id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_qo5umel66bddlnm4c5gcj2efvu	Jonathan B Weitzman	Tumor suppression by FEZ	2001	2	.pdf	application/pdf	266	51	46	PublisherName : BioMed Central PublisherImprintName : BioMed Central ArticleDOI : 10.1186/gb-spotlight-20010821-01 ArticleCitationID : spotlight-20010821-01 ArticleCopyright : BioMed Central Ltd2001 The FEZ1/LZTS1 gene maps to chromosome 8p22, a region lost in many tumors. Jefferson University, Philadelphia, describe a mechanism for FEZ1-mediated growth suppression. created an inducible gene-expression system in MCF7 breast cancer cells, in which FEZ1 expression FEZ1 expression inhibited cell growth in vitro (at the S-phase to G2/M transition in the cell cycle) and tumor formation in vivo. Ishii et al.demonstrated that the FEZ1 protein is suppress tumor growth by regulating microtubule dynamics and progression through mitosis. 1. The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in 2. Proceedings of the National Academy of Sciences , [http://www.pnas.org] 3. Thomas Jefferson University , [http://www.tju.edu] 4. FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis., http://www.pnas.org http://www.tju.edu http://www.pnas.org/cgi/content/abstract/181222898v1 http://www.pnas.org/cgi/content/abstract/181222898v1 Tumor suppression by FEZ Tumor suppression by FEZ	./cache/work_qo5umel66bddlnm4c5gcj2efvu.pdf	./txt/work_qo5umel66bddlnm4c5gcj2efvu.txt