id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_nxtajoo3ajhd3lxmxvv5vmw3bu	Farinaz Safavi	Dimethyl fumarate suppresses granulocyte macrophage colony-stimulating factor–producing Th1 cells in CNS neuroinflammation	2020	10	.pdf	application/pdf	5705	557	61	Dimethyl fumarate suppresses granulocyte macrophage colony-stimulating factor–producing Th1 cells in CNS neuroinflammation To study the immunomodulatory effect of dimethyl fumarate (DF) on granulocyte macrophage colony-stimulating factor (GM-CSF) production in CD4+ T cells in experimental autoimmune encephalomyelitis (EAE) and human peripheral blood mononuclear cells human cells and ameliorates inflammatory responses.3,4 In addition, EAE mice treated with DF show a significant reduction in GM-CSF–producing CD4+ T cells can effectively induce EAE by passive transfer, and lack of GM-CSF in Th1 DF = dimethyl fumarate; EAE = experimental autoimmune encephalomyelitis; GM-CSF = granulocyte macrophage colonystimulating factor; MNC = mononuclear cell; RRMS = relapsing-remitting MS; WT = wild type. (E) Flow cytometry analysis demonstrated that DF significantly reduced GM-CSF production in IFN-γ–producing CD4+ (Th1) cells. Figure 3 The suppressive effect of DF on GM-CSF depends on IFN-γ in murine cells DF treatment significantly decreased GM-CSF in CD4+ T cellsfromWTbut not CD4+ T cells from IFN-γ−/− mice.	./cache/work_nxtajoo3ajhd3lxmxvv5vmw3bu.pdf	./txt/work_nxtajoo3ajhd3lxmxvv5vmw3bu.txt