id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_jai4xhsisbdg3j4xhyntxar3sm	Jin O-Uchi	Tyrosine Phosphorylation of Mitochondrial Ca2+ Uniporter Regulates Mitochondrial Ca2+ Uptake	2015	1	.pdf	application/pdf	1564	118	45	We investigated the kinetics of MAC inhibition in mitochondria from wild type, Bak, and Bax knockout cell lines using Mitochondrial Ca2þ has a critical role for balancing cell survival and death. Here we show that adrenergic signaling induces MCU tyrosine phosphorylation and accelerates mitochondrial Ca Pyk2 and MCU, which subsequently accelerates mitochondrial Ca2þ uptake via confirmed that only two tyrosine sites were phosphorylated in response to adrenergic stimulation in situ using cell lines stably expressing MCU-YFs. In addition, overexpression of these MCU-YFs failed to increase mitochondrial Ca is required for activation of Akt survival pathways and mitochondrial function. At embryonic day (E) 9.5, mitochondrial ETC activity and oxidative phosphorylation (OXPHOS) are not coupled, Initiation of Electron Transport Activity and a Decrease of Oxidative Stress Occur Simultaneously during Embryonic Heart De ... The Stoichiometry between MICU1 and MCU Determines the Different Mitochondrial Ca2+ Uptake Phenotypes in Heart and Liver	./cache/work_jai4xhsisbdg3j4xhyntxar3sm.pdf	./txt/work_jai4xhsisbdg3j4xhyntxar3sm.txt