id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_i472kap5ejf5rdur3za75zbqia	J Melrose	Genetic murine models of spinal development and degeneration provide valuable insights into intervertebral disc pathobiology	2021	21	.pdf	application/pdf	16767	1705	59	Keywords: Murine model, intervertebral disc, nucleus pulposus, annulus fibrosus, spine. SMAD-3 knockout Spinal malformations and kyphosis, changes in CEP structure, and decreased IVD proteoglycan and collagen content. Defective notochord sheath, deformed NP, cell death, and reduced SHH signalling; secondary impairment of dorsalventral neural tube patterning. MCT4 knockout Disc degeneration with increased aggrecan degradation, MMP13, and type X collagen levels. Shhcre; Hif-1αfl/fl Notochordal cell loss and severely prominent fibrosis of the disc by 1 month of age. SOX5/6 double knockout Defective notochord sheath formation, apoptosis of notochord cells, and spine lacking NP. Ercc1 deficiency Advanced age-related degenerative changes in the vertebral bodies and intervertebral discs, including reduced proteoglycan content, increased apoptosis, and increased p16. Note: while perlecan is referred to as an HS-proteoglycan, intervertebral disc cells synthesise gene in notochord-derived cells results in ageassociated degeneration of IVDs, decreased levels COL9A1 knockout Premature degeneration associated with physical impairment and degenerative changes in the disc including the CEP.	./cache/work_i472kap5ejf5rdur3za75zbqia.pdf	./txt/work_i472kap5ejf5rdur3za75zbqia.txt