id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_clhxj3r6pndirghkema3cc6pny	Samir K. Ballas	From Individualized Treatment of Sickle Cell Pain to Precision Medicine: A 40-Year Journey	2016	4	.pdf	application/pdf	2330	268	62	From Individualized Treatment of Sickle Cell Pain to Precision Medicine: A 40-Year Journey In the 1970s, sickle cell pain was treated with trial and error approach Keywords: Sickle cell disease; Pain; Individualized treatment; Personalized medicine; Precision medicine An infliction in the life expectancy figure of patients with sickle cell disease (SCD) occurred around the middle of the 1970s opioids as ligands that bind to stereospecific and saturable receptors in the central nervous system and other tissues [3, 4]. by binding to receptors, opioids initiate a series of biochemical events including activation of G proteins, inhibition of Life expectancy of patients with sickle cell disease from 1900 through 2010. where life expectancy of patients with sickle cell disease began to increase. Treatment of pain in adults with sickle cell Management Evolution of Sickle Cell Pain J Clin Med Res. 2016;8(5):357-360 Management Evolution of Sickle Cell Pain J Clin Med Res. 2016;8(5):357-360	./cache/work_clhxj3r6pndirghkema3cc6pny.pdf	./txt/work_clhxj3r6pndirghkema3cc6pny.txt