id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_c4l5ipinsbgshki4bhxzahuxsi	Pablo M. Peixoto	In Search of the Structure of MAC in the Mitochondrial Outer Membrane	2010	1	.pdf	application/pdf	1470	94	43	formed in mitochondrial outer membranes (OM) of apoptotic cells or in synthetic membranes by Bax and related proteins/peptides, using electron microscopy (EM), atomic force microscopy and x-ray diffraction. MAC function was induced through staurosporine treatment and microinjection of tBid or cytochrome c. apoptosis signals MAC formation, while pDsRed-2 expression shows mitochondrial structure as red fluorescence. microinjection with tBid or cytochrome c induced relocation of Bax and collapse of the mitochondrial network. cleaved by caspase-8 and other enzymes forming tBid that induce mitochondrial outer membrane (OMM) permeabilization and cytochrome c (cyto-c) release. coordinated cyto-c release and also inhibited tBid-induced cell death. The mammalian GRIF1 and OIP106, and the drosophila Milton are kinesinbinding proteins that form a complex with the Miro GTPase, an outer mitochondrial membrane EF-hand protein, to support the movement of mitochondria Mechanism of the Mitochondrial Cytochrome C Release Wave in Bid-Induced Apoptosis	./cache/work_c4l5ipinsbgshki4bhxzahuxsi.pdf	./txt/work_c4l5ipinsbgshki4bhxzahuxsi.txt