id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_6vs5fvkrdfhtplqeqtlhi4k7zu	Michael J. Haas	GRK5: big-hearted target?	2008	3	.pdf	application/pdf	2019	144	55	G protein–coupled receptor kinase 5 in pathological cardiac hypertrophy, providing a first mechanistic target for this indication.1 kinase 5 (GRK5) is unique in hypertrophy or is redundant with other "GRK5 has been shown to be increased in heart failure," Koch Koch said that prior to aortic banding "the hearts of the GRK5 Previous work by others had also shown increased nuclear localization of GRK5 in a rat model of cardiac hypertrophy. GRK5 played a direct role in pathological hypertrophy via transcriptional regulation of genes responsible for this condition. Koch acknowledged that the effects of GRK5's role in hypertrophy Researchers contacted by SciBX agreed that Koch's team had identified an important mechanism in the development of cardiac hypertrophy, but they disagreed over whether the findings would easily pathological cardiac hypertrophy," he said. redundant with other class II HDAC kinases, Koch said the team is Koch said another study by the team targets GRK5 with a GRK5	./cache/work_6vs5fvkrdfhtplqeqtlhi4k7zu.pdf	./txt/work_6vs5fvkrdfhtplqeqtlhi4k7zu.txt