id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_3tjweo4oardnnnj3kni7maaymi	Tudor Toma	Antisense oligonucleotide treatment for human astrocytoma	2001	2	.pdf	application/pdf	315	48	45	PublisherName : BioMed Central PublisherImprintName : BioMed Central ArticleDOI : 10.1186/gb-spotlight-20010423-01 ArticleCitationID : spotlight-20010423-01 ArticleCopyright : BioMed Central Ltd2001 Active antisense oligonucleotides directed against the insulin-like growth factor type I receptor (IGFIR/AS ODN) have shown potential as an antitumour agent in animal studies. Journal of Clinical Oncology David Andrews and colleagues from Thomas Jefferson University Hospital, Philadelphia, describe their novel implantation of IGF-IR/AS ODN-treated cells in patients studied 12 patients treated by surgery for malignant astrocytoma. collected at surgery were treated ex vivo with an IGF-IR/AS ODN and reimplanted in the rectus sheath Examination of the IGF-IR/AS ODN-treated cells after a 24-hour in situ IGF-IR was down regulated to 10% after ex vivo antisense treatment (J Clin Oncol 2001, suggests that ex vivo IGF-IR/AS ODN treatment of autologous glioma cells can induce apoptosis and an insulin-like growth factor type i receptor in malignant astrocytomas. 2. Thomas Jefferson University Hospital, [http://www.jeffersonhospital.org/show.asp?durki=3858] http://www.jeffersonhospital.org/show.asp?durki=3858	./cache/work_3tjweo4oardnnnj3kni7maaymi.pdf	./txt/work_3tjweo4oardnnnj3kni7maaymi.txt