id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_gcuvbyz775hvreexzcxs7ike74	Jordan L. Scott	Spatial and Temporal Regulation of the Nedd4 Family of E3 Ubiquitin Ligases through Phospholipid Binding	2013	1	.pdf	application/pdf	1524	99	41	Spatial and Temporal Regulation of the Nedd4 Family of E3 Ubiquitin Ligases through Phospholipid Binding results directly from a change in the lipid binding capacities of the AH, we employ a Single Liposome Curvature Sensing (SLiC) assay. VP40 is a high affinity lipid binding and membrane curvature-inducing protein Results were indicative of VP40's high affinity and specificity for PS in a PS-concentration dependent manner demonstrating the robust ability of VP40 to penetrate membranes. These domains have previously been shown to bind phospholipids and to be required for the localization of some members to the plasma membrane. lipid binding properties of the Nedd4 family C2 domains to vesicles of specific Finally, we are using both confocal microscopy and immunoblotting to determine how lipid binding regulates the ubiquitination state of Nedd4 family binding, which may facilitate temporal regulation of functional membrane Separation of Timescales for Endophilin Dimerization and Membrane Binding	./cache/work_gcuvbyz775hvreexzcxs7ike74.pdf	./txt/work_gcuvbyz775hvreexzcxs7ike74.txt