id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_qm3rt3v2mfbwnogxff46ue4fga	John Worrall	What Evidence in Evidence‐Based Medicine?	2002	16	.pdf	application/pdf	6979	467	60	by exploring in particular the EBM position on RCTs (randomized controlled trials). 7. For example, Doll and Peto (1980) write that the main objection to historically controlled trials and the main reason why RCTs are superior is "that the criteria for selecting patients for treatment with an exciting new agent or method may differ from historically controlled trials tended to produce more "statistically significant" results and more highly positive point-estimates of the effect than little evidence that estimates of treatment effects in observational studies reported after 1984 are either consistently larger than or qualitatively different from those obtained in randomized, controlled trials J. Hartz (2000), "A Comparison of Observational Studies and Randomised, Controlled Trials", New England Journal of Medicine 342: 1878–1886. (1983), "Bias in Treatment Assignment in Controlled Clinical Trials", New England Journal of Medicine 309: I. Horwitz (2000), "Randomised Controlled Trials, Observational Studies, and the Hierarchy of Research Designs", New England Journal of Medicine 342: 1887–1892.	./cache/work_qm3rt3v2mfbwnogxff46ue4fga.pdf	./txt/work_qm3rt3v2mfbwnogxff46ue4fga.txt