untitled CASE REPORT Repetitive Transcranial Magnetic Stimulation for Treatment of Depression in a Patient With Severe Traumatic Brain Injury Alessandro Iliceto, MD, 1 Rachel L Seiler, MD, MPH, 1 Korak Sarkar, MD 1,2 1 The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA 2 Department of Neurology, Ochsner Clinic Foundation, New Orleans, LA Background: Traumatic brain injury (TBI) commonly presents with a constellation of findings, including physical, cognitive, and psychological disturbances. Traditionally, few options have been available for long-term management of mood symptoms for post-TBI patients who are refractory to medications. Repetitive transcranial magnetic stimulation (rTMS) is a promising alternative treatment. Case Report: A 37-year-old male with history of anxiety and bipolar depression incurred a TBI after a 60-foot fall. After his physical recovery, the patient had refractory depression. Eight months after the TBI event, he underwent a 6-week course of rTMS treatment and had a 70.8% improvement in mood symptoms by the end of the therapy as indicated by the Patient Health Questionnaire-9, transitioning from severe to mild depression according to the scoring system. Clinical correlation during the months following conclusion of rTMS therapy showed no signs of remission or adverse side effects. The patient remains stable and lives independently 1 year after treatment with mood-stabilizing medications. Conclusion: This case provides evidence for successful treatment of refractory depressive symptoms after severe TBI with the addition of rTMS to psychotherapy and mood-stabilizing medications, supporting the safety and tolerability of this novel therapeutic approach. Further studies are needed to validate the contribution of rTMS for management of mood symptoms in patients with TBI. Keywords: Brain injuries–traumatic, depression, repetitive transcranial magnetic stimulation Address correspondence to Korak Sarkar, MD, Department of Neurology, Ochsner Clinic Foundation, 1514 Jefferson Hwy., New Orleans, LA 70121. Tel: (504) 897-5854. Email: korak.sarkar@ochsner.org INTRODUCTION Traumatic brain injuries (TBIs) are projected to affect a growing number of Americans each year, already increasing from an estimated 1.9 million in 2007 to 2.8 million in 2013, according to a 2017 report. 1 The most common post-TBI morbidity is major depressive disorder (MDD), with typically reported symptoms of fatigue, frustration, and poor con- centration. 2-4 Traditionally, treatment modalities have been limited to the customary multifactorial rehabilitation, pharma- cotherapy, and psychotherapy approach of the biopsycho- social model. 5 However, interest has increased in the use of repetitive transcranial magnetic stimulation (rTMS) as a potential non- pharmacologic alternative therapeutic tool for modulating brain function. 6 This noninvasive method of stimulating nerve cells in the brain uses a magnetic field that generates a current to modulate brain activity, 7 and rTMS is thought to have an effect on brain plasticity during the chronic phase of recovery (>3 months post-TBI) that can help overcome long-term cognitive deficits after injury. 8,9 The inaugural case study showed the benefit of rTMS in reducing depres- sive symptoms. 10 The use of rTMS has since been validated via other studies that provided evidence of equally promis- ing outcomes in the management of unipolar and bipolar depression. 11-13 However, this form of therapy has not been thoroughly evaluated in the post-TBI patient popula- tion, particularly in patients with severe TBI, because of a lack of data regarding its safety and efficacy. In this study, we add to the limited amount of available lit- erature supporting the safe and successful use of rTMS in the treatment of refractory depression in a patient with a his- tory of severe TBI. Additionally, this case study showcases a new model of therapy that incorporates rTMS treatment in conjunction with current standard therapeutic approaches. CASE REPORT A 37-year-old male with a medical history of anxiety and bipolar disorder type I sustained a 60-foot fall in July 2015 Ochsner Journal 18:264–267, 2018 © Academic Division of Ochsner Clinic Foundation DOI: 10.31486/toj.17.0075 264 Ochsner Journal from a suicide attempt. The fall resulted in a closed head in- jury and multiple rib and pelvic fractures. The patient was in a coma for 11-12 days with a Glasgow Coma Scale score of 3. He required an intensive care unit stay with a tracheos- tomy tube for respiratory support. Initial brain scans with gra- dient recalled echo T2-weighted imaging showed diffuse axonal injury (Figure). This type of magnetic resonance im- aging (MRI) allows for greater sensitivity in detecting micro- hemorrhages compared to conventional MRI or computed tomograpy imaging. 14 After discharge from the hospital, the patient was admitted to a neurologic rehabilitation facility where he initially endorsed cognitive decline and visual processing deficits. He also displayed signs of dysarthria, in- termittent dysphagia, and retrograde and anterograde am- nesia with no recollection of the accident, in addition to self-reported fatigue and insomnia. The patient physically improved at the rehabilitation facility until discharge in Octo- ber 2015 but continued to endorse severe depressive symp- toms with recurrent suicidal ideation. Symptoms were refractory to increased dosages of his psychiatric medica- tions that included bupropion 300 mg daily before noon, olanzapine 5 mg at bedtime, oxcarbazepine 150 mg twice daily, and lamotrigine 100 mg daily. Trazodone 100 mg at bedtime was added to manage insomnia. A multifaceted ap- proach was adopted in collaboration with the patient’s neu- rologist in an attempt to control his mood symptoms, including pet therapy, supportive groups (eg, regular church attendance, National Alliance on Mental Illness group meet- ings), and lifestyle modifications. In March 2016, the attend- ing psychiatrist changed the patient’s medication regimen, substituting quetiapine 200 mg for olanzapine because of lack of response and adding methylphenidate 40 mg daily to improve concentration. Despite these changes, the pa- tient continued to endorse suicidal ideation, and his ability to function (eg, live independently, interact with others in so- cial situations) remained dramatically impaired. Because of the severity and refractory nature of his condition, he was re- ferred to an outside psychiatrist to discuss the possibility of rTMS therapy. Of note, the patient did not endorse any manic symptoms throughout these evaluations, and he did not experience any posttraumatic seizure following the TBI. An rTMS treatment course was adopted using standard depression protocols. 15 The patient’s rTMS treatment appa- ratus consisted of the NeuroStar TMS Therapy System (v.2.3.3). Coil position was set at 10.3 cm anterior/posterior, zero-degree angle, and stimulus onset asynchronies of 33 degrees. The patient underwent 30 treatment sessions in the outpatient setting (5 days of therapy per week for 6 weeks) of 1-hour and 2-minute duration per session. High- frequency stimulation at 6 Hz over the left dorsolateral pre- frontal cortex was used. Treatment was set at a standard motor threshold (MT) level of 1.62 with treatment intensity at 120% of MT level, a 4-second stimulation time, and a 26-second interstimulation interval for a total of 3,000 pulses administered per session. The patient completed the treat- ment course between March 2016 and May 2016. The patient’s mood symptoms were quantitatively evalu- ated throughout the treatment protocol using the Patient Health Questionnaire-9 (PHQ-9) to self-report mood symp- toms during psychiatry visits. The patient scored 24 on the PHQ-9 after 1 week of rTMS therapy, placing him on the se- vere depression spectrum. As shown in the patient’s weekly scores (Table), mood improvement was observed within 2 weeks of initiating treatment when the patient’s score de- creased to 16 (moderately severe depression). After 1 month of therapy, the patient reported being more functional and was able to relocate to an apartment and live by himself without further endorsement of suicidal ideation. At the end of 6 weeks of therapy, the patient’s score improved to 7 (mild depression), constituting a 70.8% reduction in score from the beginning to the conclusion of his rTMS treatment protocol. The patient was regularly followed by the psychia- trist and neurologist who did not note clinical or self-reported adverse effects to the therapy. Subsequent visits focused on community reintegration, which included defining interests, long-term life goals, and the possibility of obtaining employment. The patient was amenable to volunteering at the rehabilitation facility where he had resided during the initial treatment for his TBI. At 2-year follow-up, he has not endorsed further mood de- compensations or suicidal ideation, he has not required additional hospitalizations, and he maintains functional inde- pendence by living in his own apartment. He remains on the same medication regimen and reports adequate compli- ance with no severe adverse effects. DISCUSSION The improvement in mood symptoms demonstrated by this patient is consistent with results of the few published case studies on the use of rTMS 16,17 and provides further support for the safe and effective clinical use of rTMS for re- fractory depression in post-TBI patients, without significant side effects. The PHQ-9 questionnaire used to track the patient’s re- sponse to rTMS is a well-established method for objectively measuring the severity of major depressive symptoms (ranked on scale 0-3 ranging from “not at all” to “nearly every day”) in multiple contexts of personal emotions, feel- ings, and daily life activities. Classification of depression level is determined by the PHQ-9 composite score of each item set and ranges from minimal depression (total score 1-4) to severe depression (total score 20-27). 18 The PHQ-9 has proved to be useful for initial evaluation and for monitor- ing treatment and relapses of patients with MDD. 19 The results of the PHQ-9 that the patient completed through- out his treatment period showed a clear improvement in Figure. Gradient recalled echo sequence shows hemosider- in deposition consistent with mild diffuse axonal injury (arrows). Volume 18, Number 3, Fall 2018 265 Iliceto, A self-reported mood symptoms over time that was corrobo- rated by medical professionals during follow-up visits. Some other studies on this topic have used provider- based assessments of mood, such as the Hamilton Depres- sion Rating Scale (HAM-D), 20,21 so our results cannot be di- rectly compared to those. One study, despite documenting a decrease in mood symptoms with the HAM-D from base- line to follow-up, did not show a concurrent significant self- reported decrease in symptoms according to the PHQ-9, dif- fering from our findings. 17 TBI was considered a relative contraindication to the use of rTMS because of the risk of seizures. 22 This case report and several aforementioned studies 6,8,16,17 have shown that rTMS can be safely used in the TBI population. Our pa- tient tolerated 30 sessions of high-frequency rTMS without any seizures or other clinical adverse effects. Limitations to this case study that warrant consideration in- clude the lack of a true baseline quantitative evaluation of the patient’s depressive symptoms prior to the TBI or the start of rTMS therapy. The patient did not receive any formal testing of his functional abilities; they were assessed by the neurol- ogist based upon the patient’s self-reported evaluation dur- ing each consultation. Moreover, several changes in the patient’s psychiatric medication regimen started around the time of rTMS therapy initiation, including the substitution of quetiapine for olanzapine and the addition of methylpheni- date. Consequently, determining the level of contribution of rTMS to his self-reported change in mood is not possible; the mood changes might have resulted from the alterations in his pharmacotherapy during the treatment protocol. How- ever, prior attempts to adjust the patient’s medications, in- cluding dose and class, did not show consistent evidence of mood symptom improvement. Finally, if the patient may suffer from possible long-term effects from rTMS therapy is unclear, as the last treatment was administered in May 2016. Worth noting, however, is that the therapy resulted in a sustained and profound long-lasting improvement in the patient’s functional level from his debilitating mental illness, justifying the decision for aggressive management. CONCLUSION Despite the increasing use of rTMS as a noninvasive ther- apy for a variety of psychological and cognitive symptoms, it has not yet been recognized as a standard adjunct therapy in the TBI population. Concerns remain regarding the safety and longevity of rTMS therapy, given that the physiologic ef- fects of the treatment and the extent of stimulation that may be administered without seizure induction are not fully un- derstood. Our case report is one of the few documented studies of successful rTMS use for debilitating mood symp- toms in patients who previously incurred a severe TBI. It pro- vides further evidence regarding the safety of this type of treatment and its positive impact when used in combination with other therapeutic interventions. Powered studies are needed to validate the contribution of rTMS in the treatment of severe depression in the post-TBI populace. 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This article meets the Accreditation Council for Graduate Medical Education and the American Board of Medical Specialties Maintenance of Certification competencies for Patient Care and Medical Knowledge. Volume 18, Number 3, Fall 2018 267 Iliceto, A