© The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. S88 Review Article Evidence-Based Nonpharmacological Practices to Address Behavioral and Psychological Symptoms of Dementia Kezia Scales, PhD,1 Sheryl Zimmerman, PhD,2,3,* and Stephanie J. Miller, MSW3 1PHI, Bronx, New York. 2School of Social Work and 3Cecil G. Sheps Center for Health Services Research, The University of North Carolina at Chapel Hill. *Address correspondence to: Sheryl Zimmerman, PhD, Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, 725 Martin Luther King Jr. Blvd., Chapel Hill, NC 27599. E-mail: Sheryl_Zimmerman@unc.edu. Received: March 15, 2017; Editorial Decision Date: September 15, 2017 Decision Editor: Beth A. Kallmyer, MSW Abstract Background and Objectives: To draw from systematic and other literature reviews to identify, describe, and critique non- pharmacological practices to address behavioral and psychological symptoms of dementia (BPSDs) and provide evidence- based recommendations for dementia care especially useful for potential adopters. Research Design and Methods: A search of systematic and other literature reviews published from January 2010 through January 2017. Nonpharmacological practices were summarized to describe the overall conceptual basis related to effective- ness, the practice itself, and the size and main conclusions of the evidence base. Each practice was also critically reviewed to determine acceptability, harmful effects, elements of effectiveness, and level of investment required, based on time needed for training/implementation, specialized care provider requirements, and equipment/capital requirements. Results: Nonpharmacological practices to address BPSDs include sensory practices (aromatherapy, massage, multi-sen- sory stimulation, bright light therapy), psychosocial practices (validation therapy, reminiscence therapy, music therapy, pet therapy, meaningful activities), and structured care protocols (bathing, mouth care). Most practices are acceptable, have no harmful effects, and require minimal to moderate investment. Discussion and Implications: Nonpharmacological practices are person-centered, and their selection can be informed by considering the cause and meaning of the individual’s behavioral and psychological symptoms. Family caregivers and paid care providers can implement evidence-based practices in home or residential care settings, although some practices require the development of more specific protocols if they are to become widely used in an efficacious manner. Keywords: Behavioral and psychological symptoms of dementia (BPSD), Nonpharmacological, Dementia care, Recommendations, Evidence, Review Behavioral and psychological symptoms of demen- tia (BPSDs) are among the most distressing sequelae of Alzheimer’s disease and related dementias. They include agitation, aberrant motor behavior, anxiety, irritability, depression, apathy, disinhibition, delusions, hallucina- tions, and sleep or appetite changes (Cerejeira, Lagarto, & Mukaetova-Ladinska, 2012). Up to 97% of persons living with dementia experience at least one BPSD, the most com- mon being apathy, depression, irritability, agitation, and anxiety (Steinberg et al., 2008). BPSDs result from changes in the brain in relation to characteristics of the social and physical environment, as explained by three complemen- tary conceptual models described below. In the material that follows, the focus is on modifiable factors in the social The Gerontologist cite as: Gerontologist, 2018, Vol. 58, No. S1, S88–S102 doi:10.1093/geront/gnx167 D ow nloaded from https://academ ic.oup.com /gerontologist/article-abstract/58/suppl_1/S 88/4816740 by B ernetta E vans user on 16 A ugust 2019 mailto:Sheryl_Zimmerman@unc.edu?subject= and physical environment, which is not to minimize the important role of unmodifiable neurodegeneration associ- ated with dementia (Kales, Gitlin, & Lyketsos, 2015). The competence-environmental press framework conceives of BPSDs as reflecting the interplay of cogni- tive capacity and external environmental stressors; sim- ply stated, environmental forces influence (“press” on) an individual’s psychological state and evoke a behavio- ral response (Lawton & Nahemow, 1973). For example, when confronted with bath water that is an uncomfortable temperature, a person living with dementia may strike out rather than convey discomfort through words. The progres- sively lowered stress threshold model expands the concept of press. It suggests that environmental antecedents pro- duce stress, which is met by a coping response that is com- promised by the progressive impact of dementia; BPSDs emerge as environmental demands exceed stress-tolerance or coping thresholds (Hall & Buckwalter, 1987). A behav- ioral example explained by this model is an individual who becomes agitated in response to an environment made noisy through overhead speakers and persistent talk. The needs-driven dementia-compromised behavior model conceives of BPSDs as an attempt to communicate an unmet need; they reflect a response to antecedent environmental or social stimuli based on person-specific characteristics such as personality and cognitive and functional status (Algase et al., 1996). Within this framework, BPSDs are considered meaningful expressions, ranging from disengagement (e.g., apathy) to mild discomfort (e.g., pacing) to urgent need (e.g., physical aggression). As an example, a person living with dementia who “wanders” may be communicating the need to leave a situation that is causing mild anxiety. If the need is not addressed, symptoms will persist and may become more severe (Kovach, Noonan, Schlidt, & Wells, 2005), perhaps escalating from wandering to exit seeking. Understanding the triggers of BPSDs has allowed for the development and testing of social and environmental practices (i.e., interventions or treatments) to reduce or eliminate those symptoms. Such practices are especially desirable given that antipsychotic and other psychotropic medications are generally contraindicated for the treatment of BPSDs; not only is there is limited evidence of benefit (Sink, Holden, & Yaffe, 2005), but the use of antipsychotic medications to treat this population is associated with higher risk of myocardial infarction (Pariente et al., 2012), stroke (Douglas & Smeeth, 2008), and mortality (Kales et al., 2012). In fact, regulations state that antipsychotic medications should be considered to treat BPSDs only in instances when the symptoms present a danger, and only after “medical, physical, functional, psychological, emo- tional, psychiatric, social and environmental causes have been identified and addressed” (CMS, 2013). Similarly, physical restraints are contraindicated to address BPSDs, as they can result in injury and negatively affect cognition, mood, and opportunities for social interaction (Scherder, Bogen, Eggermont, Hamers, & Swaab, 2010). It is recommended that practices to address BPSDs build from broader dementia care principles, which include sim- plifying tasks (breaking each task into simple steps, using verbal and/or tactile prompts); communicating clearly and calmly and allowing sufficient time for the individual’s response; aligning activities with the individual’s preference and capacity and providing support as needed; and engag- ing with the individual in a simplified environment that is free from clutter and distractions, using visual cues for ori- entation (Gitlin, Kales, & Lyketsos, 2012). Family caregiv- ers and formal care providers of people living with dementia often need education/training about these principles, as well as how to recognize BPSDs, their triggers, and strategies to alleviate them (Spector, Orrell, & Goyder, 2013). To date, a number of systematic and literature reviews have identified evidence-based nonpharmacological prac- tices to address BPSDs. Consistent with the conceptual approaches described above, these reviews have highlighted the utility of identifying characteristics of the social and physical environment that trigger or exacerbate BPSDs. However, not all reviews have focused specifically on out- comes related to BPSDs (e.g., one systematic review exam- ined “health outcomes” that included BPSDs; Zimmerman et al., 2013) and others have been specific to settings of care (e.g., a Cochrane review of dementia special care units; Lai, Yeung, Mok, & Chi, 2009). Furthermore, few of the reviews present and summarize the conceptual underpinnings of the individual practices, which is important information for considering when, why, and for whom a practice may be effective. Furthermore, there has been limited attention to the investment required for each practice, in terms of time requirements (such as for training and implementation), the need for specialized care providers, and equipment and capital resource requirements, all of which are important in the context of crafting recommendations for dementia care. Therefore, the intent of this article is to serve as an applied review of the literature that summarizes evidence-based nonpharmacological practices to address BPSDs, describes the practices in some detail, critiques them in terms of their investment requirements, and derives related recommenda- tions for dementia care. Other reviews have not typically provided information to help potential users understand the conceptual basis underlying practices or the time investment necessary to implement them; consequently, this article is unique in its relevance for potential adopters. Design and Methods To identify evidence-based nonpharmacological practices to address BPSDs, a search of systematic and other literature reviews published in English from January 2010 through January 2017 was conducted. The 2010 start date focused this review on the most up-to-date assessments of a body of literature that has been growing for several decades; the majority of reviews have been published since 2010, but most cover evidence published since 1990 or earlier. Search The Gerontologist, 2018, Vol. 58, No. S1 S89 D ow nloaded from https://academ ic.oup.com /gerontologist/article-abstract/58/suppl_1/S 88/4816740 by B ernetta E vans user on 16 A ugust 2019 terms included “systematic (or literature) review,” “demen- tia (or Alzheimer’s disease),” “behavioral and psychological symptoms of dementia” (and synonyms), and “interventions” (and related terms). Search databases included PubMed, CINAHL, PsycINFO, AgeLine, and Cochrane. As needed, articles identified from the reference lists of the reviews were themselves reviewed for clarification or more information; additionally, so as to be inclusive, a small number of indi- vidual studies on BPSD practices that were identified during the search but not yet evaluated in systematic reviews were included in this review and synthesis. Review articles that addressed the experiences and outcomes of caregivers them- selves were not included, although we recognize the essential link to the experiences and outcomes of the person living with dementia (Gitlin, Marx, Stanley, & Hodgson, 2015). As a literature review and synthesis, this article presents evi- dence that has already been evaluated using a priori inclu- sion criteria and standards of rigor rather than replicating existing systematic review efforts. It does not evaluate the qualities of the reviews themselves, but it is important to note that they all met the standards of peer review. The identified BPSD practices were summarized to describe the overall conceptual basis of each practice, the practice itself, and related evidence. Then, the evidence base for each practice was critically reviewed by the authors to determine apparent/likely acceptability to participants, reported/poten- tial harmful effects, potential elements of effectiveness, and investment required. As the included reviews used different criteria to search and evaluate the strength of the evidence, the intention in this article was to broadly summarize the findings across the reviews for potential adopters rather than specifically quantify the number of Level I, Level II, and Level III studies on each practice. Thus, the size of the evi- dence base for each practice was heuristically characterized as small (when the systematic reviews that were summarized in this review tended to identify fewer than five studies meet- ing inclusion criteria and supporting the BPSD practice in question), moderate (5–10 studies), or large (more than 10 studies); to note, these categories served as a general guide for summarizing the extent of the evidence rather than precise quantifications. The main conclusions from the evidence were characterized as positive (if positive effects were reported across the reviews), mixed (if negative effects were also iden- tified), or preliminary (if the evidence base was too small to evaluate). Investment was rated as low, moderate, or high, in relation to time needed for training and implementation, spe- cialized care provider requirements, and equipment or capital requirements, based on an adaptation of an existing frame- work. As shown in Table 1, low investment requires <2 hr of training and <15 min to implement, no specialized care pro- vider requirements, and material purchases <$100 with no environmental modification; high investment requires >4 hr of training and >60  min to implement, a specialized care provider, and material purchases >$500 with ongoing cost >$100/month and extensive environmental modification; and moderate involvement lies between the two extremes for all categories (Seitz et al., 2012). Overall, the literature itself did not quantify the investment required of each practice, so the authors used their judgment based on these criteria. The Results section presents the practices, conceptual basis, evidence, and implementation; Tables 2–4 provide additional details regarding evidence. Results From the database search, 197 articles reporting evidence- based nonpharmacological practices to treat BPSDs were reviewed, and 14 single articles were also reviewed for their detail on particular practices. The practices that were identified have been classified here in three overarching cat- egories: sensory practices (aromatherapy, massage, multi- sensory stimulation, and bright light therapy), psychosocial practices (validation therapy, reminiscence therapy, music therapy, pet therapy, and meaningful activities), and struc- tured care protocols (bathing and mouth care). Sensory Practices Normal aging is associated with gradual decline across the five senses—visual, auditory, kinesthetic, olfactory, and Table 1. Criteria to Rate Investment Required for Nonpharmacological Practices to Treat BPSDs Low investment Moderate investment High investment Time required for training and implementation <1 hr of training 1–4 hr of training >4 hr of training <15 min to implement 15–60 min to implement >60 min to implement Specialized care provider requirements None Implemented by usual care provider but requires specialized knowledge Not implemented by usual care provider Equipment or capital resources Material purchase <$100 with no ongoing cost Material purchase $100–$500 Ongoing cost <$100/month Some environmental modification Material purchase >$500 Ongoing cost >$100/month Extensive environmental modification No environmental modification Note: BPSDs = behavioral and psychological symptoms of dementia. The Gerontologist, 2018, Vol. 58, No. S1S90 D ow nloaded from https://academ ic.oup.com /gerontologist/article-abstract/58/suppl_1/S 88/4816740 by B ernetta E vans user on 16 A ugust 2019 gustatory—which can lead to loss of independence, social isolation, disorientation and confusion, safety risks, and other adverse outcomes (Raina, Wong, & Massfeller, 2004; Schneider et al., 2011). Sensory change is also specifically associated with cognitive impairment, although the nature and degree of this association is still under investigation (Behrman, Chouliaras, & Ebmeier, 2014). Older persons liv- ing with dementia are therefore particularly vulnerable to sen- sory deficits, which can reduce their capacity to interpret and manage the demands of their environment (consistent with the progressively lowered stress threshold model described in the Introduction). An individual who has trouble seeing, for example, may be easily startled and distressed by noises that are not clearly identifiable, leading to anxiety or agitation. Sensory practices comprise a range of techniques for correcting sensory imbalances, increasing alertness, reduc- ing anxiety and agitation, and enhancing quality of life (Fitzsimmons, Barba, & Stump, 2014; Strøm, Ytrehus, & Grov, 2016). Prominent among these tested techniques are aromatherapy, massage, multisensory stimulation (MSS), and bright light therapy. It is recommended that sensory practices are supported by basic care practices that help minimize confusion and enhance orientation, such as ensuring that individuals have functional hearing aids and eyeglasses, and that the care environment is well-lit and easily navigable (Behrman et  al., 2014); together, these practices can help individuals better tolerate the press from their environment. Table 2. Sensory Practices Practice Description Summary of evidence Assessment of implementation and investment Aromatherapy Administration of scented oils (e.g., lavender or lemon balm), via diffusion, patches, or skin cream, to induce calm and positive affect. Moderate evidence base Well accepted by participants Evidence is mixed; indicates positive effect on agitation No known harmful effects Autonomic nervous system regulation and social/physical contact may be key elements of effectiveness Low investment (minimal time, usual caregiver, modest resources) More high-quality research required, using consistent implementation protocols and outcome measures Massage Tactile or therapeutic touch applied to back, shoulders, necks, hands, or feet by qualified massage therapist or by trained staff or family members, to induce calm and positive affect. Small evidence base Well accepted by participants Evidence indicates positive effects on agitation, aggression, anxiety, depression, disruptive vocalizations More high-quality research required, using consistent implementation protocols and outcome measures and conducted with larger samples No known harmful effects, although individual preference regarding physical touch should be assessed and honored Physiological response and social/ physical contact may be key elements of effectiveness Low investment (minimal time, usual caregiver, modest resources) Multisensory stimulation Stimulation of multiple senses through a combination of light effects, calming sounds, smells, and/or tactile stimulation, to overcome apathy or induce calm. Large evidence base Well accepted by participants Evidence indicates positive effects on agitation, anxiety, apathy, depression No known harmful effects Social contact may be key element of effectiveness Moderate investment (moderate time, usual caregiver, moderate resources) More high-quality research required, using consistent implementation protocols and outcome measures and conducted with larger samples Bright light therapy Exposure to simulated or natural lighting designed to help promote synchronization of circadian rhythms with environmental light–dark cycles. Moderate evidence base Degree of acceptance varies by light source Some potential for harmful effects Evidence is mixed, showing both positive and negative effects More high-quality research required, especially with natural lighting Change to circadian rhythm may be key element of effectiveness Moderate investment (moderate time, usual caregiver, low or moderate resources) The Gerontologist, 2018, Vol. 58, No. S1 S91 D ow nloaded from https://academ ic.oup.com /gerontologist/article-abstract/58/suppl_1/S 88/4816740 by B ernetta E vans user on 16 A ugust 2019 Table 3. Psychosocial Practices Practice Description Evidence Assessment of implementation and investment Validation therapy Individual or group practice designed to validate the perceived reality and emotional experience of the individual. Small evidence base Well accepted by participants Evidence is mixed; some evidence of positive effects on agitation, apathy, irritability, night-time disturbance No known harmful effects, although care providers should ensure that negative emotions are not exacerbated through validation More high-quality research required on the specific effects on BPSDs Alleviating negative feelings and enhancing positive feelings may be key elements of effectiveness Low investment (minimal time, usual caregiver, modest resources) Reminiscence therapy Individual or group practice designed to induce positive affect through a focus on happy memories, often using photographs or other prompts. Moderate evidence base Well accepted by participants Evidence indicates positive effects on mood, depressive symptoms More high-quality research required on the specific effects on BPSDs No known harmful effects, although care providers should help focus reminiscence on positive memories Increasing well-being and providing pleasure and cognitive stimulation may be key elements of effectiveness Moderate investment (moderate time, usual or special caregiver, modest resources) Music therapy Receptive or participatory activities designed to promote well-being, foster sociability, create familiarity, and reduce anxiety. Moderate evidence base Evidence indicates positive effects on a range of BPSDs, including anxiety, agitation, and apathy, particularly with personalized music practices Degree of acceptance varies by participant’s preference for music No known harmful effects Promoting well-being and sociability, aiding reminiscence, reducing anxiety/stress, and providing distraction may be key elements of effectiveness Moderate investment (moderate time, usual or special caregiver, modest resources) More high-quality research with larger samples required Pet therapy Structured or unstructured time with animals, primarily dogs, to promote well-being, socialization and emotional support, and sensory stimulation. Small evidence base Evidence is preliminary, with some evidence of positive effects on agitation, apathy, disruptive behavior Degree of acceptance varies by participant’s preference for contact with animals Negative outcomes may include allergic reactions, hygiene concerns, or anxiety/agitation Socialization/bonding, emotional support, and sensory stimulation may be key elements of effectiveness Low to moderate investment (minimal to moderate time, usual or special caregiver, modest to moderate resources) Stuffed or robotic pets may be an effective substitute for live animals More high-quality research with larger samples and consistent implementation protocols required Meaningful activities Provision of activities designed to enhance quality of life through engagement, social interaction, and opportunities for self-expression and self-determination. Moderate evidence base Evidence is mixed, but shows some positive effects on agitation; larger effect sizes for activities that are individually tailored Degree of acceptance varies by appropriateness of activity No known harmful effects, except for expected risks associated with physical engagement in activities Enhancing quality of life, social interaction, and opportunities for self-expression and self- determination may be key elements of effectiveness Low to moderate investment (moderate time, usual or special caregiver, modest resources) Some evidence for positive effect of physical exercise activities on agitation and depressive symptoms More high-quality research with larger samples and longer duration required Note: BPSDs = behavioral and psychological symptoms of dementia. The Gerontologist, 2018, Vol. 58, No. S1S92 D ow nloaded from https://academ ic.oup.com /gerontologist/article-abstract/58/suppl_1/S 88/4816740 by B ernetta E vans user on 16 A ugust 2019 Aromatherapy Aromatherapy is based on the long-standing practice of using scented oils, such as lavender or Melissa oil (lemon balm), to “regulate body activities by control and acti- vation of the autonomic nervous system and the neuro- endocrine system” (Press-Sandler, Freud, Volkov, Peleg, & Press, 2016). Given the link between smell and memory, the scent of essential oils (aromatic compounds found in seeds, bark, stems, roots, flowers, and other plant parts) can potentially improve an individual's mood if linked to positive memories; even as olfaction decreases, how- ever, essential oils may have a direct effect on the brain (Behrman et al., 2014). A number of studies have tested the efficacy of aroma- therapy for agitation and aggression in dementia. In these studies, the practice has been administered using room diffusion, sachets, a patch, or skin cream; and dosage has ranged from 3  min to 24  hr for a period of 2–360  days (Strøm et  al., 2016). Recent reviews of the moderate evi- dence base for aromatherapy in dementia have found mixed results (Forrester et  al., 2014; Livingston et  al., 2014; Press-Sandler et  al., 2016; Strøm et  al., 2016). For example, one descriptive analysis of randomized controlled trials concluded that applying oil closer to the olfactory system was associated with positive outcomes, whereas the type of oil or duration of treatment made no explanatory difference (Press-Sandler et al., 2016). A different review of practices for agitation in nursing homes (Livingston et al., 2014) found that aromatherapy has not been effective when assessors are masked to the treatment. Despite the need for more large-scale efficacy trials, cur- rent evidence indicates that aromatherapy is well accepted by participants with no harmful effects. Social and physical contact may be a key therapeutic element in aromatherapy practices, such as when scents are provided through the application of a hand cream (Ballard, O’Brien, Reichelt, & Perry, 2002). Our review of aromatherapy suggests that required investment is low, given minimal time needed for learning and implementation, no need for a specialized care provider, and modest resource requirements. Massage As a nonverbal means of communication or connection, massage may help offset the social isolation that triggers negative affect and related behaviors (Behrman et al., 2014). Through tactile connection, a person living with dementia may feel comforted and cared about, especially in residen- tial care environments where touch tends to be instrumen- tal and task specific (Gleeson & Timmins, 2004); by the same token, massage may help familiarize the person with his/her care provider and thereby reduce resistance to per- sonal care (Fitzsimmons et al., 2014). Touch may also incur a physiological response, for example a sense of reassur- ance or calm mediated by the production of oxytocin, and meaningful sensory stimulation may help counteract cogni- tive decline (Hansen, Jorgensen, & Ortenblad, 2006). Massage may be applied to different parts of the body, including back, shoulders, neck, hands, or lower legs and feet, using slow or large strokes, rubbing or kneading, non- contact therapeutic touch, or acupressure (Hansen et  al., 2006). A small evidence base shows positive results for the effectiveness of massage in helping reduce agitation, aggres- sion, stress, anxiety, depression, and disruptive vocaliza- tions in the immediate or short term (Kales et  al., 2015; Moyle, Murfield, O’Dwyer, & Van Wyk, 2013; Randall & Clissett, 2016; Staedtler & Nunez, 2015; Strøm et  al., 2016; Hansen, Jorgensen, & Ortenblad, 2006). Massage appears to be well accepted by participants; it is recommended that individual preference be assessed, however, as the increased stimulation may increase agita- tion (O’Neil et al., 2011). Our review suggests that min- imal investment is required to implement massage practices (minimal time demands, no need for a specialized care pro- vider, and few capital resources). However, the diversity of massage techniques and outcomes suggests that develop- ment of specific protocols would be beneficial to enhance Table 4. Structured Care Protocols Practice Description Evidence Assessment of implementation and investment Mouth care Structured protocols for providing mouth care that include person-centered communication and interaction strategies as well as technical skills. Small evidence base Well accepted by participants Evidence is preliminary; one study found positive effects on care-resistant behaviors No known harmful effects Reducing threat, anxiety, fear, and pain may be key elements of effectiveness Low investment (low time, usual caregiver, modest resources) More high-quality research required Bathing Structured protocols for providing bathing care that include person-centered communication and interaction strategies as well as technical skills. Small evidence base Well accepted by participants No known harmful effects Reducing fear and pain may be key ele- ments of effectiveness Low investment (low time, usual caregiver, modest resources) Evidence indicates positive effects on agitation, aggression, irritability, anxiety More high-quality research required, using consistent implementation protocols and outcome measures The Gerontologist, 2018, Vol. 58, No. S1 S93 D ow nloaded from https://academ ic.oup.com /gerontologist/article-abstract/58/suppl_1/S 88/4816740 by B ernetta E vans user on 16 A ugust 2019 the consistent application and effectiveness of touch-based practices (Moyle et al., 2013). Web-based training modules may be especially beneficial in this regard (Tuohy, Graham, Johnson, Tuohy, & Burke, 2015). Multisensory Stimulation Originating in the learning disabilities field (Burns, Cox, & Plant, 2000), MSS is designed to provide “a stress-free, entertaining environment both to stimulate and to relax” (Sánchez, Millán-Calenti, Lorenzo-López, & Maseda, 2013, p. 7), which does not require cognitive processing or short-term memory (Behrman et  al., 2014). Because MSS environments are designed to be explored by the individ- ual in his/her own way, MSS is also intended to promote control and autonomy, which may otherwise be denied to persons living with dementia. MSS involves the stimulation of multiple senses through a combination of light effects, calming sounds, smells, and/or tactile stimulation (Sánchez et  al., 2013). Practices have ranged from three sessions (in total) to daily ses- sions over 15 months, averaging 30 min/session. A leading example of MSS is Snoezelen, a model that includes music, aroma, bubbles, fiberoptic sprays, and projected images (O’Connor, Ames, Gardner, & King, 2009). Other MSS approaches include sensory gardens (Goto, Kamal, Puzio, Kobylarz, & Herrup, 2014) and the incorporation of sen- sory stimulation into daily care routines (Van Weert, van Dulmen, Spreeuwenberg, Ribbe, & Bensing, 2005; Whall et al., 1997). From the large but diverse body of research on MSS practices, there is positive evidence for the effects of MSS on reducing short-term anxiety, agitation, and apathy (Baker et  al., 2003; Millán-Calenti et  al., 2016; Sánchez et al., 2013). As with aromatherapy and massage, evidence also suggests that part of the therapeutic benefit of indi- vidualized MSS practices may be the dyadic interaction involved (Maseda et al., 2014). MSS appears to be well accepted, with no negative effects. Different from the other sensory practices, however, our review suggests that moderate investment in resources and time is required. Once resources are secured, care pro- vider time is the primary ongoing cost. As with massage, there is a need for more clearly defined protocols and care provider training to implement MSS (Bauer, Rayner, Koch, & Chenco, 2012). Bright Light Therapy Normal aging is associated with changes in the circadian sleep-rest cycle that may result in fragmented nocturnal sleep, including multiple and prolonged awakenings, and increased daytime sleep (Forbes, Blake, Thiessen, Peacock, & Hawranik, 2014). In persons living with dementia, these sleep disturbances tend to be exacerbated by degenerative changes in the suprachiasmatic nuclei (SCN) of the hypo- thalamus, which generates the circadian rhythm, and can result in BPSDs such as agitation and sundowning. Bright light therapy is designed to promote the synchronization of circadian rhythms with environmental light-dark cycles through stimulation of the SCN (Behrman et  al., 2014). This practice may be particularly important for nursing home residents, who otherwise receive limited exposure to bright light (Sloane et al., 2007). Light therapy can be delivered through a light box, a light visor, ceiling-mounted light fixtures, “naturalistic” lighting that simulates twilight transitions (Forbes et  al., 2014), or exposure to natural bright light (Dowling et al., 2008). Practices have ranged from 2,500 to 10,000 lux exposure for 1–2 hr for 10 days to 2 months (Brasure et al., 2016). The evidence base for bright light therapy is moder- ate but shows mixed results. One recent review found insuf- ficient evidence to recommend light therapy for reducing sleep disturbance or other BPSDs, such as agitation (Forbes et  al., 2014); another review found low-strength evidence showing that bright light therapy is similar to standard light in managing agitation and aggression (Brasure et al., 2016). Other reviews have found no efficacy for light ther- apy and that it may actually worsen agitation (Livingston et  al., 2014), although others have found positive effects on agitation and sleep (Cabrera et  al., 2015), and mixed results for depression (Hanford & Figueiro, 2013). Overall, the evidence suggests that bright light therapy may have some therapeutic benefit for reducing agitation, depression, and/or sleep disturbance in some individuals living with dementia, although further research is required. Monitoring is critically important to ensure that bright light does not increase agitation. Our review suggests that bright light therapy requires moderate investment (as it can be administered by the usual care provider with add- itional time and with low to moderate capital investment). Acceptability may be increased and investment require- ments decreased by using natural light (opening windows, going outdoors) or ambient light rather than individual light boxes, which are more expensive and less usable with mobile individuals (Hickman et al., 2007). Psychosocial Practices As described in the Introduction, a number of conceptual models explain the emergence of BPSDs as an interaction between an individual’s neurological changes and their surrounding environment. Individuals living with demen- tia may experience anxiety, for example, because memory problems render their surroundings unrecognizable, espe- cially in residential care settings where daily interactions are not supported by long-term memories. Psychosocial practices are specific strategies intended to create a person- centered environment (see Fazio, Pace, Flinner, & Kallmyer, 2018) to help prevent or alleviate BPSDs and improve overall quality of life (Testad et al., 2014; Vernooij-Dassen, Vasse, Zuidema, Cohen-Mansfield, & Moyle, 2010); in this context, they are consistent with the person-centered focus of the needs-driven dementia-compromised behavior model. Prominent practices of this type include validation The Gerontologist, 2018, Vol. 58, No. S1S94 D ow nloaded from https://academ ic.oup.com /gerontologist/article-abstract/58/suppl_1/S 88/4816740 by B ernetta E vans user on 16 A ugust 2019 therapy, reminiscence therapy, music therapy, pet therapy, and meaningful activities. Validation Therapy Rooted in Rogerian humanistic psychology (Livingston, Johnston, Katona, Paton, & Lyketsos, 2005), validation therapy focuses on accepting the reality of the person living with dementia. By focusing empathically on the emotional content of a person’s words or expressions, the aim of val- idation therapy is to alleviate negative feelings and enhance positive feelings. Validation therapy is implemented through a number of communication techniques, including using nonthreatening words to establish understanding; rephrasing the person’s words; maintaining eye contact and a gentle tone of voice; responding in general terms when meanings are unclear; and using touch if appropriate (Mitchell & Agnelli, 2015). The evidence base for validation therapy is small and shows mixed findings. A recent review of personalized psy- chosocial practices for BPSDs (Testad et al., 2014) identi- fied two validation therapy studies: one study of validation therapy and sensorial reminiscence therapy conducted twice weekly for 12 weeks, with each session lasting 45–60 min, found significant improvements for behavioral dis- turbance compared to controls (Deponte & Missan, 2007); the other study, which included both individual (20 min, three times per week) and group sessions (45–60 min weekly), found decreased agitation, apathy, irritability, and night-time disturbance (Tondi, Ribani, Bottazzi, Viscomi, & Vulcano, 2007). However, several other reviews found insufficient evidence for the efficacy of validation therapy in reducing BPSDs (Livingston et al., 2005; O’Connor et al., 2009; O’Neil et al., 2011). Although the evidence base for validation therapy is underdeveloped, the concept of honoring the feelings of the person living with dementia has face validity as part of person-centered dementia care (Kitwood, 1997). Validation therapy is a low investment practice, as it can be integrated into care by usual care providers after modest investment in communication training. Negative effects appear minimal, although there may be risk that an individual’s feelings of distress could be exacerbated through validation therapy if care providers are not sufficiently prepared to both honor and alleviate those feelings. Reminiscence Therapy Reminiscence therapy involves discussion of past events and experiences with the aim of increasing well-being and providing pleasure and cognitive stimulation (Cabrera et al., 2015). It relates to Erikson’s theory of psychosocial development, in which the final “wisdom” stage (posited as age 65 years and older) is characterized by retrospection, or looking back over one’s life (Kasl-Godley & Gatz, 2000). The approach is also based on the concept that older mem- ories are more enduring than recent memories (Cammisuli, Danti, Bosinelli, & Cipriani, 2016). Introduced in the 1980s, reminiscence therapy has been considered by some to be “one of the most popular psychosocial interventions in dementia care” (Cotelli, Manenti, & Zanetti, 2012). Reminiscence therapy can be conducted with an indi- vidual or in a group, guided by either free recall (through conversation), specific stimuli (e.g., photographs, music), or a life-review method (often by creating a life-history book). Reminiscence therapy has been tested in 30- to 60-min sessions, one to two times per week for 3–8 weeks (Testad et al., 2014). There is a moderate base of evidence supporting its positive effects on mood, depression, and agitation or distress in the short term; however, the evi- dence is limited by sample size and heterogeneity, lack of blinded post-treatment assessment, and lack of information about adherence (Cabrera et  al., 2015; Cammisuli et  al., 2016; Cotelli et al., 2012; Huang et al., 2015; Testad et al., 2014). One review found strongest evidence for the benefit of reminiscence therapy in improving mood and depressive symptoms, with four studies reporting significant benefits compared to control (Testad et al., 2014). As with validation therapy, reminiscence therapy fits well within a broader, person-centered approach that aims to recognize and honor the individual (Mitchell & Agnelli, 2015). In residential care settings, learning about each per- son’s personal history and meaningful events is considered important for combatting isolation and loneliness (Huang et al., 2015). Validation therapy requires moderate invest- ment in training and implementation time; an optional expenditure is the cost of audio-visual aids, such as film projectors or music players (Lazar, Thompson, & Demiris, 2014). There is no evidence of adverse effects of reminis- cence therapy (Woods, Spector, Jones, Orrell, & Davies, 2005), although the onus is on care providers to guide rem- iniscence toward positive memories, rather than negative memories that may cause distress. Music Therapy Music may help prevent or alleviate distressing symptoms of dementia in a number of ways. As a leisure activity, music is thought to promote well-being and fosters sociability in part by offsetting the isolation that can result from progressive loss of verbal ability (Cammisuli et al., 2016). Furthermore, because musical memory is generally retained longer than other memories, music can facilitate reminiscence and potentially reduce anxiety through general mind activation and specific memory triggers (Spiro, 2010). Consistent with the progressively lowered stress threshold model, music may reduce stress by creating a sense of familiarity and regularity in the environment (Behrman et al., 2014). Broadly, musical activities can be classified as either receptive (listening to music) or participatory (mak- ing music; Mitchell & Agnelli, 2015). Practices include personalized music delivered through iPods or as part of daily care, or group sessions using prerecorded music or delivered by staff or music therapists (Chang et  al., 2015). They have generally been implemented for up to The Gerontologist, 2018, Vol. 58, No. S1 S95 D ow nloaded from https://academ ic.oup.com /gerontologist/article-abstract/58/suppl_1/S 88/4816740 by B ernetta E vans user on 16 A ugust 2019 1  hr, two to three times per week, for an average of 10 weeks (Ueda, Suzukamo, Sato, & Izumi, 2013). A number of reviews have found a moderate evidence base support- ing the positive effects of music therapy on the short-term reduction of a range of BPSDs, including anxiety, agitation, and apathy (Cammisuli et  al., 2016; Chang et  al., 2015; Gómez-Romero et  al., 2017; Kales et  al., 2015; Konno, Kang, & Makimoto, 2014; Livingston et al., 2014; Millán- Calenti et al., 2016; Strøm et al., 2016; Ueda et al., 2013). A  recent meta-analysis concluded that individual music therapy provided once a week and group music therapy provided several times a week are optimal for reducing dis- ruptive behaviors, anxiety, and depressive mood (Chang et  al., 2015). Another review of music therapy for agita- tion found evidence for individualized music practices and interactive modalities (e.g., clapping, singing, and dancing; Millán-Calenti et  al., 2016). A  number of other studies have supported the efficacy of personalized or preferred music (Doody et  al., 2001; Garland, Beer, Eppingstall, & O’Connor, 2007; Sung, Chang, & Lee, 2010). Music therapy appears to be an enjoyable and effect- ive approach to alleviate BPSDs and create well-being. Our review suggests that investment is moderate, as time and training are required to set up and sustain a music pro- gram; more resources are required over the long term for group sessions led by a music therapist than for individ- ualized recorded music sessions. Music therapy does not appear to have adverse effects although, and as with other BPSD practices, a personalized approach is recommended so that the practice aligns with the individual’s preference. Pet Therapy Pet therapy, also known as animal-assisted therapy, has been used for several decades to treat mental and physical health disorders, including in dementia, intending to pro- mote socialization and emotional support, sensory stimu- lation, and enhanced well-being (Bernabei et  al., 2013). Physiologically, quiet interaction with an animal can help lower blood pressure and increase production of neuro- chemicals associated with relaxation and bonding, which may in turn reduce BPSDs (Filan & Llewellyn-Jones, 2006). Pet therapy in dementia, most often involving dogs, has been tested daily or one to two times per week for 30–90  min for 1–12 weeks, in a structured or unstruc- tured format (Bernabei et al., 2013). In small studies, it has reduced agitation and disruptive behavior, increased social and verbal interactions, and decreased passivity (Bernabei et  al., 2013; Brodaty & Burns, 2012; Filan & Llewellyn- Jones, 2006; Strøm et al., 2016). Preliminary studies using a robotic dog or cat—which may be more feasible to imple- ment by reducing maintenance costs, but does require initial capital investment—have shown positive increases in mood and decreased agitation (Bernabei et  al., 2013; Petersen, Houston, Qin, Tague, & Studley, 2017). Overall, there is a small and preliminary evidence base for pet therapy, with most studies using quasi-experimental or repeated measure within-participant designs (Livingston et al., 2014; O’Neil et al., 2011). Although the evidence is too preliminary is too prelim- inary to permit specific recommendations, our review sug- gests that pet therapy is a practice that requires minimal to moderate investment, depending on the initial or ongoing costs of acquiring and/or caring for the animal. Specialized training and resource allocation may be required to care for and handle the animal or to contract with an outside agency, unless stuffed or robotic pets are used in place of live animals. Negative outcomes may include allergic reac- tions, hygiene concerns, or anxiety/agitation among some individuals, such as those who had negative experiences with animals in the past. Meaningful Activities The provision of individualized, meaningful activities is considered an important element of person-centered care and may help prevent or alleviate BPSDs by enhanc- ing overall quality of life through engagement, enhanced social interaction, and opportunities for self-expression and self-determination (Han, Radel, McDowd, & Sabata, 2016). By contrast, lack of meaningful activity is cited by persons living with dementia and family members as one of the most “persistent and critical” unmet needs (Trahan, Kuo, Carlson, & Gitlin, 2014). The importance of tailor- ing activities is noted as particularly important for ensuring that individuals are able to fully participate and benefit, regardless of their cognitive capacity or functional abilities (Trahan et al., 2014). These practices comprise a range of leisure and social activities, also known as recreational activities, usually tailored to the individual’s preferences, cognitive and func- tional abilities, lifelong habits and roles, and memories and past experiences (Han et  al., 2016). Overall, the evidence base for individualized activities is moderate, with mixed findings. A  recent review found that nonindividualized meaningful activities reduced mean agitation levels in the short run, with mixed findings about the additional bene- fit of individualizing activities according to functional level and interest; there was a lack of evidence about longer- term effect (Livingston et  al., 2014). Other reviews have found more support for individually tailored activities (Brodaty & Burns, 2012; de Oliveira et  al., 2015); how- ever, evidence is still insufficient to draw conclusions about the comparative effectiveness of practices tailored to dif- ferent characteristics (Brasure et  al., 2016). As a specific type of activity, there is some evidence for the effectiveness of exercise programs (including endurance, strength train- ing, and/or general physical activation; Fleiner, Leucht, Förstl, Zijlstra, & Haussermann, 2017) on agitation and depressive symptoms for individuals living with dementia, although effect sizes are small and the evidence is limited by heterogeneous designs, small samples, and short practices (Barreto, Demougeot, Pillard, Lapeyre-Mestre, & Rolland, 2015; Brett, Traynor, & Stapley, 2016; Forbes, Forbes, The Gerontologist, 2018, Vol. 58, No. S1S96 D ow nloaded from https://academ ic.oup.com /gerontologist/article-abstract/58/suppl_1/S 88/4816740 by B ernetta E vans user on 16 A ugust 2019 Blake, Thiessen, & Forbes, 2015; Potter, Ellard, Rees, & Thorogood, 2011). Like other nonpharmacological practices for BPSDs, the provision of meaningful activities is consistent with the broader aims of person-centered care. Investment required for implementation varies depending on the type of activ- ity, but in most cases will be low to moderate; meaningful activities take time, but can often be facilitated by regu- lar care providers or informal caregivers without extensive additional training. Structured Care Protocols Personal care routines can trigger a range of negative feel- ings and experiences for individuals, including pain or dis- comfort, fear, and embarrassment (O’Connor et al., 2009); the needs-driven dementia-compromised behavioral model suggests that BPSDs represent meaningful expressions of these feelings and experiences. Good mouth care, for example, is important for maintaining or improving qual- ity of life and reducing risk of morbidity and mortality; however, practices such as tooth brushing are often resisted by persons living with dementia due to pain and/or the intimate and potentially intrusive nature of the practice (Zimmerman, Sloane, Cohen, & Barrick, 2014). Similarly, bathing can create embarrassment or anxiety as well as discomfort, including due to arthritic pain experienced during movement (Dunn, Thiru-Chelvam, & Beck, 2002). Structured care protocols, adapted to an individual’s needs and preferences, may help family caregivers and care pro- viders implement care in a person-centered and technically proficient way that avoids or minimizes pain and other behavioral triggers. Of course, in all instances, pain itself should be assessed—such as through facial cues, body move- ments, and/or vocalizations—and appropriately addressed, including with medication if indicated (Achterberg et  al., 2013; Husebo, Ballard, & Aarsland, 2011; Kovach et  al., 2006; Pieper et al., 2013). Mouth Care Anticipated resistance to daily mouth care (e.g., tooth brushing or mouth swabbing) is one of the reasons that oral hygiene tends to be neglected for people living with demen- tia, especially in residential care settings (Zimmerman et al., 2013). Anxiety or agitation during mouth care may be the manifestation of a limbic threat identification and fear response, a response that is progressively less medi- ated by cortical control in cognitive impairment (Jablonski, Therrien, & Kolanowski, 2011). Using mouth care proto- cols that include person-centered strategies for approach- ing, communicating with, and touching the individual, along with technical skills, may help reduce threat and thereby minimize resistive behaviors. This review found that the evidence base for the effect of mouth care protocols on global or individual BPSDs is small and preliminary. One review (Konno et  al., 2014) found evidence from one pilot study that mouth care using an ability-focused, threat-reduction approach administered over a 2-week period significantly improved care-resistant behaviors (Jablonski et  al., 2011). Findings from another evidence-based practice, ‘Mouth Care without a Battle’, suggest that care providers who have been trained to use a mouth care protocol feel more able to effectively address behavioral responses during care (Zimmerman et al., 2014). From the limited evidence, our assessment is that little investment is required to implement structured protocols to prevent or minimize BPSDs during mouth care. Minimal capital expenditures include appropriate toothbrushes and other mouth-care supplies. However, training is required to ensure that family caregivers and other care providers are well prepared to implement the protocol appropriately, effectively, and consistently. No harmful effects have been identified. Bathing An intimate activity inscribed by cultural norms and indi- vidual preferences, bathing is the personal care task associ- ated with the highest frequency of behavioral expressions of distress for persons living with dementia (Gozalo, Prakash, Qato, Sloane, & Mor, 2014). As with mouth care, distress during bathing may signify a fear response that may poten- tially be alleviated by implementing person-centered strate- gies and skills. A range of bathing protocols have been tested for a duration of 2–6 weeks, with a primary focus on providing person-centered showers or bed baths (depending on the individual’s preference) and enhancing the bathing environ- ment through preferred music or calming sounds. Results from this small evidence base suggests that bathing pro- tocols show positive results in reducing agitation, aggres- sion, irritability, and anxiety as well as physical discomfort (Konno et  al., 2014; O’Connor et  al., 2009; Pieper et  al., 2013), but more high-quality studies are required (Kales et al., 2015). Our review suggests that implementing structured pro- tocols for bathing requires minimal investment, given that they can be incorporated into ongoing care by usual staff, with some training and support. No harmful effects have been identified. Discussion A large body of research indicates that a range of sensory practices, psychosocial practices, and structured care pro- tocols can be effective to some extent in addressing BPSDs, thus aligning with the causal mechanisms described in the competence-environmental press framework, the progres- sively lowered stress threshold model, and the needs-driven dementia-compromised model. Although the evidence base for virtually every practice requires further development, it was possible to identify a conceptual justification for the The Gerontologist, 2018, Vol. 58, No. S1 S97 D ow nloaded from https://academ ic.oup.com /gerontologist/article-abstract/58/suppl_1/S 88/4816740 by B ernetta E vans user on 16 A ugust 2019 potential effectiveness of each one (e.g., meaningful activi- ties conceptualized as addressing a critical unmet need for social engagement expressed through anxiety or apathy). Furthermore, all can be implemented with minimal to moderate investment of time and resources, and depend- ing on the investment required, most of the practices can be implemented by family caregivers in home-based set- tings as well as by paid care providers in other settings, suggesting a good likelihood of “management continu- ity” (Haggerty et  al., 2003) across care settings. Broadly speaking, enhanced continuity of care is associated with reduced health care use, cost, and complications (Hussey et  al., 2014). In dementia specifically, continuity of care may also help promote the “continuation of self and nor- mality” that has been articulated by individuals and their families as the core of person-centered care (Edvardsson, Fetherstonhaugh, & Nay, 2010). Two caveats are noted regarding use of evidence-based practices to address BPSDs. First, conceptual models of BPSDs indicate that practices should reflect environmental press as experienced by the individual, his/her experience of stress and coping reaction(s), and his/her specific unmet need(s). Considered this way, practices should be respon- sive to the perspective of the person living with dementia, support his/her sense of self, promote individualization and relationship building, and structure an environment that promotes well-being (Fazio et al., 2018). In sum, nonphar- macological practices to treat BPSDs are recommended to be person-centered. For example, the potential for validation or reminiscence therapy to evoke distressing memories for a particular individual requires careful consideration, and pet therapy may only be acceptable to individuals who are comfortable around animals. However, little literature has specifically examined outcomes in relation to the extent to which practices have been individually chosen and tailored, which seems an area important for future study; in fact, it may be the lack of individualization that in some cases is responsible for inconclusive evidence. For this reason, it is important that systems be put in place to evaluate the effectiveness of practices and allow for change as needed. The process of selecting and monitoring practices to evalu- ate their individual effectiveness is usefully captured by the Describe, Investigate, Create, Evaluate (DICE) cycle for the person-centered management of BPSDs (Kales, Gitlin, & Lyketsos, 2014). Second, many practices for BPSDs lack readily access- ible evidence-based protocols for administration. The absence of such protocols means that family caregivers and other care providers do not have sufficient guidance to implement practices that are likely to be efficacious as part of their caregiving efforts. Given that many of the manuscripts reviewed for this article were derived from research that used standardized protocols, creating a tool- kit of evidence-based practices for BPSDs seems an easy next step to improve the quality of life of people living with dementia. Once such protocols are available, care providers are advised to adhere to the protocols of administration to ensure that practices are used. That said, the protocols themselves may need to evolve over time, given the pro- gressive nature of dementia and the individualized nature of BPSDs. An additional consideration relates to the investment required to enact the practices. The typology used in this article (Seitz et  al., 2012) provides general categories of time investment (combining time for training and imple- mentation) and equipment or capital costs (combining initial and ongoing costs). It is conceivable, however, that more finite figures or a different classification would bet- ter describe “investment” for a given user. For example, a practice that requires >4 hr of training is considered to be a high investment, but if it may be implemented in <15 min, a user might then rate it as a moderate, or perhaps low, investment. Indeed, the developers suggest that if a prac- tice does not meet all criteria within a category, it may best be assigned to the next lowest category. Therefore, consid- eration and ratings of investment are best individualized, which is consistent with the overall person-centered focus of care provision. Based on this synthesis of findings from previous sys- tematic reviews, and a critical consideration of implementa- tion and investment required to implement evidence-based practices to address BPSDs, the following five practice rec- ommendations are suggested: 1. Identify characteristics of the social and physical envir- onment that trigger or exacerbate behavioral and psy- chological symptoms for the person living with demen- tia. BPSDs result from changes in the brain in relation to characteristics of the social and physical environment; this interplay elicits a response that conveys a reaction, stress, or an unmet need and affects the quality of life of the person living with dementia. The environmental triggers of BPSDs and responses to them differ for each person, meaning that assessment must be individualized and person-centered. 2. Implement nonpharmacological practices that are person centered, evidence based, and feasible in the care setting. Antipsychotic and other psychotropic medications are generally not indicated to alleviate BPSDs, and so non- pharmacological practices should be the first-line ap- proach. Practices that have been developed in residential settings and which may also have applicability in com- munity settings include sensory practices, psychosocial practices, and structured care protocols. 3. Recognize that the investment required to implement nonpharmacological practices differs across care settings. Different practices require a different amount of invest- ment in terms of training and implementation, special- The Gerontologist, 2018, Vol. 58, No. S1S98 D ow nloaded from https://academ ic.oup.com /gerontologist/article-abstract/58/suppl_1/S 88/4816740 by B ernetta E vans user on 16 A ugust 2019 ized caregiver requirements, and equipment and capital resources. Depending on the investment required, some practices developed in residential settings may be feasible for implementation by caregivers in home-based settings. 4. Adhere to protocols of administration to ensure that practices are used when and as needed, and sustained in ongoing care. Protocols of administration assure that there is a “guide- line” for care providers as they strive to alleviate BPSDs. These protocols may evolve over time, responsive to the particular components of the practice that are most ef- fective for the person living with dementia. 5. Develop systems for evaluating the effectiveness of prac- tices and make changes as needed. The capacity and needs of persons living with dementia evolve over time, and so practices to alleviate BPSDs also may need to evolve over time. Therefore, it is necessary to routinely assess the effectiveness of the practice and, if neces- sary, adapt it or implement other evidence-based practices. Funding This work was supported by a grant from the National Institute on Aging (grant R01 AG0284690). Dr. Scales’s effort was addition- ally supported by a National Institutes of Health T32 Postdoctoral Fellowship through the Duke University Center for the Study of Aging and Human Development (5T32AG000029-40). This article was published as part of a supplement sponsored and funded by National Office of the Alzheimer’s Association. Conflict of Interest None reported. References Achterberg, W. P., Pieper, M. J., van Dalen-Kok, A. H., de Waal, M. W., Husebo, B. S., Lautenbacher, S., & Corbett, A. 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