id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_yrcib3occzcotnsggj44sdglsa	João D. G. Correia	Radiometallated peptides for molecular imaging and targeted therapy	2011.0	24	.pdf	application/pdf	23029	3494	79	peptide receptors are overexpressed in certain tumors, as compared to endogenous expression levels, has radiometallated peptides for nuclear molecular imaging and/or targeted radionuclide tumor therapy. regulatory peptide receptors in tumor tissues.2,3,5–7,11 The availability of different techniques to generate potential high-affinity extensively used for the radiometallation of peptides, most probaTable 2 Stability constants (logK ML a ) for complexes of polyaminocarboxylates with divalent and trivalent metal ions first 99mTc-labeled RGD-containing compounds.118,119 The resulting radiometallated peptides correspond most likely to Tc(V) bearing a PEGylated C-terminus and a diamine-dioxime chelator for complexation of Tc(V), was used to prepare 99mTcNC100692 (Fig. 7).120–122 The ability of 99mTc-NC100692 to detect metastatic lesions in 15 patients with lung cancer and 10 integrin binding affinity and much higher tumor uptake in MDAMB-435 breast cancer xenograft than [99mTc(HYNIC-PEG4N-terminally conjugated to DOTA and labeled with 111In. Biodistribution studies in mice with AR42J tumors showed with 111In, using DOTA, and the resulting complex [111In-DOTALys4,Phe7,Pro34]-NPY showed a high kidney and low tumor uptake	./cache/work_yrcib3occzcotnsggj44sdglsa.pdf	./txt/work_yrcib3occzcotnsggj44sdglsa.txt