id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_fwpygjl5sjgubcwonytnssqlka	Stuart G. Baker	Development Tracks for Cancer Prevention Markers	2004	7	.pdf	application/pdf	4781	360	52	We provide a general framework for describing various roles for biomarkers in cancer prevention research (early detection, surrogate endpoint, and cohort identification for primary prevention) and the phases in their evaluation. purposes are early detection (with the goal of early intervention), surrogate endpoints (with the goal of having shorter studies) and cohort identification (of individuals with the greatest benefit to harm ratio associated with primary prevention). In the past, most markers for cancer screening involved changes in cell types (such as degrees of dysplasia) or single proteins in serum such as PSA or CA125. difficulties we discuss, the main use of surrogate endpoints may be in a preliminary study of an intervention on evaluating multiple trials with surrogate and true An alternative design, which we have not seen applied or discussed, is a single trial involving randomization to multiple interventions with surrogate and true randomized trials of cancer screening, BMC Medical Research	./cache/work_fwpygjl5sjgubcwonytnssqlka.pdf	./txt/work_fwpygjl5sjgubcwonytnssqlka.txt