id	sid	tid	token	lemma	pos
10_1101-2021_02_13_429885	1	1	A	a	DT
10_1101-2021_02_13_429885	1	2	fully	fully	RB
10_1101-2021_02_13_429885	1	3	automated	automate	VBN
10_1101-2021_02_13_429885	1	4	approach	approach	NN
10_1101-2021_02_13_429885	1	5	for	for	IN
10_1101-2021_02_13_429885	1	6	quality	quality	NN
10_1101-2021_02_13_429885	1	7	control	control	NN
10_1101-2021_02_13_429885	1	8	of	of	IN
10_1101-2021_02_13_429885	1	9	cancer	cancer	NN
10_1101-2021_02_13_429885	1	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	1	11	in	in	IN
10_1101-2021_02_13_429885	1	12	the	the	DT
10_1101-2021_02_13_429885	1	13	era	era	NN
10_1101-2021_02_13_429885	1	14	of	of	IN
10_1101-2021_02_13_429885	1	15	high	high	JJ
10_1101-2021_02_13_429885	1	16	-	-	HYPH
10_1101-2021_02_13_429885	1	17	resolution	resolution	NN
10_1101-2021_02_13_429885	1	18	whole	whole	JJ
10_1101-2021_02_13_429885	1	19	genome	genome	JJ
10_1101-2021_02_13_429885	1	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	1	21	A	a	DT
10_1101-2021_02_13_429885	1	22	fully	fully	RB
10_1101-2021_02_13_429885	1	23	automated	automate	VBN
10_1101-2021_02_13_429885	1	24	approach	approach	NN
10_1101-2021_02_13_429885	1	25	for	for	IN
10_1101-2021_02_13_429885	1	26	quality	quality	NN
10_1101-2021_02_13_429885	1	27	control	control	NN
10_1101-2021_02_13_429885	1	28	of	of	IN
10_1101-2021_02_13_429885	1	29	cancer	cancer	NN
10_1101-2021_02_13_429885	1	30	mutations	mutation	NNS
10_1101-2021_02_13_429885	1	31	in	in	IN
10_1101-2021_02_13_429885	1	32	the	the	DT
10_1101-2021_02_13_429885	1	33	era	era	NN
10_1101-2021_02_13_429885	1	34	of	of	IN
10_1101-2021_02_13_429885	1	35	high	high	JJ
10_1101-2021_02_13_429885	1	36	-	-	HYPH
10_1101-2021_02_13_429885	1	37	resolution	resolution	NN
10_1101-2021_02_13_429885	1	38	whole	whole	JJ
10_1101-2021_02_13_429885	1	39	genome	genome	JJ
10_1101-2021_02_13_429885	1	40	sequencing	sequence	VBG
10_1101-2021_02_13_429885	1	41	Jacob	Jacob	NNP
10_1101-2021_02_13_429885	1	42	Househam	Househam	NNP
10_1101-2021_02_13_429885	1	43	,	,	,
10_1101-2021_02_13_429885	1	44	​Barts	​bart	VBZ
10_1101-2021_02_13_429885	1	45	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	1	46	Institute	Institute	NNP
10_1101-2021_02_13_429885	1	47	,	,	,
10_1101-2021_02_13_429885	1	48	Queen	Queen	NNP
10_1101-2021_02_13_429885	1	49	Mary	Mary	NNP
10_1101-2021_02_13_429885	1	50	University	University	NNP
10_1101-2021_02_13_429885	1	51	of	of	IN
10_1101-2021_02_13_429885	1	52	London	London	NNP
10_1101-2021_02_13_429885	1	53	,	,	,
10_1101-2021_02_13_429885	1	54	UK	UK	NNP
10_1101-2021_02_13_429885	1	55	William	William	NNP
10_1101-2021_02_13_429885	1	56	CH	CH	NNP
10_1101-2021_02_13_429885	1	57	Cross	Cross	NNP
10_1101-2021_02_13_429885	1	58	,	,	,
10_1101-2021_02_13_429885	1	59	​UCL	​UCL	NNP
10_1101-2021_02_13_429885	1	60	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	1	61	Institute	Institute	NNP
10_1101-2021_02_13_429885	1	62	,	,	,
10_1101-2021_02_13_429885	1	63	University	University	NNP
10_1101-2021_02_13_429885	1	64	College	College	NNP
10_1101-2021_02_13_429885	1	65	London	London	NNP
10_1101-2021_02_13_429885	1	66	,	,	,
10_1101-2021_02_13_429885	1	67	UK	UK	NNP
10_1101-2021_02_13_429885	1	68	(	(	-LRB-
10_1101-2021_02_13_429885	1	69	★	★	NNP
10_1101-2021_02_13_429885	1	70	)	)	-RRB-
10_1101-2021_02_13_429885	1	71	Giulio​	Giulio​	NNP
10_1101-2021_02_13_429885	1	72	​Caravagna	​Caravagna	NNP
10_1101-2021_02_13_429885	1	73	,	,	,
10_1101-2021_02_13_429885	1	74	​	​	JJ
10_1101-2021_02_13_429885	1	75	​Department	​department	NN
10_1101-2021_02_13_429885	1	76	of	of	IN
10_1101-2021_02_13_429885	1	77	Mathematics	Mathematics	NNP
10_1101-2021_02_13_429885	1	78	and	and	CC
10_1101-2021_02_13_429885	1	79	Geosciences	Geosciences	NNP
10_1101-2021_02_13_429885	1	80	,	,	,
10_1101-2021_02_13_429885	1	81	University	University	NNP
10_1101-2021_02_13_429885	1	82	of	of	IN
10_1101-2021_02_13_429885	1	83	Trieste	Trieste	NNP
10_1101-2021_02_13_429885	1	84	,	,	,
10_1101-2021_02_13_429885	1	85	Italy	Italy	NNP
10_1101-2021_02_13_429885	1	86	(	(	-LRB-
10_1101-2021_02_13_429885	1	87	★	★	NNP
10_1101-2021_02_13_429885	1	88	)	)	-RRB-
10_1101-2021_02_13_429885	1	89	Joint	joint	JJ
10_1101-2021_02_13_429885	1	90	last	last	JJ
10_1101-2021_02_13_429885	1	91	authors	author	NNS
10_1101-2021_02_13_429885	1	92	.	.	.
10_1101-2021_02_13_429885	2	1	(	(	-LRB-
10_1101-2021_02_13_429885	2	2	★	★	LS
10_1101-2021_02_13_429885	2	3	)	)	-RRB-
10_1101-2021_02_13_429885	2	4	Corresponding	corresponding	NN
10_1101-2021_02_13_429885	2	5	:	:	:
10_1101-2021_02_13_429885	2	6	​(GC	​(GC	NNP
10_1101-2021_02_13_429885	2	7	)	)	-RRB-
10_1101-2021_02_13_429885	2	8	​gcaravagna@units.it​.	​gcaravagna@units.it​.	ADD
10_1101-2021_02_13_429885	3	1	Abstract	abstract	JJ
10_1101-2021_02_13_429885	3	2	.	.	.
10_1101-2021_02_13_429885	4	1	​Cancer	​cancer	DT
10_1101-2021_02_13_429885	4	2	is	be	VBZ
10_1101-2021_02_13_429885	4	3	a	a	DT
10_1101-2021_02_13_429885	4	4	global	global	JJ
10_1101-2021_02_13_429885	4	5	health	health	NN
10_1101-2021_02_13_429885	4	6	issue	issue	NN
10_1101-2021_02_13_429885	4	7	that	that	WDT
10_1101-2021_02_13_429885	4	8	places	place	VBZ
10_1101-2021_02_13_429885	4	9	enormous	enormous	JJ
10_1101-2021_02_13_429885	4	10	demands	demand	NNS
10_1101-2021_02_13_429885	4	11	on	on	IN
10_1101-2021_02_13_429885	4	12	healthcare	healthcare	NN
10_1101-2021_02_13_429885	4	13	systems	system	NNS
10_1101-2021_02_13_429885	4	14	.	.	.
10_1101-2021_02_13_429885	5	1	Basic	basic	JJ
10_1101-2021_02_13_429885	5	2	research	research	NN
10_1101-2021_02_13_429885	5	3	,	,	,
10_1101-2021_02_13_429885	5	4	the	the	DT
10_1101-2021_02_13_429885	5	5	development	development	NN
10_1101-2021_02_13_429885	5	6	of	of	IN
10_1101-2021_02_13_429885	5	7	targeted	target	VBN
10_1101-2021_02_13_429885	5	8	treatments	treatment	NNS
10_1101-2021_02_13_429885	5	9	,	,	,
10_1101-2021_02_13_429885	5	10	and	and	CC
10_1101-2021_02_13_429885	5	11	the	the	DT
10_1101-2021_02_13_429885	5	12	utility	utility	NN
10_1101-2021_02_13_429885	5	13	of	of	IN
10_1101-2021_02_13_429885	5	14	DNA	DNA	NNP
10_1101-2021_02_13_429885	5	15	sequencing	sequence	VBG
10_1101-2021_02_13_429885	5	16	in	in	IN
10_1101-2021_02_13_429885	5	17	clinical	clinical	JJ
10_1101-2021_02_13_429885	5	18	settings	setting	NNS
10_1101-2021_02_13_429885	5	19	,	,	,
10_1101-2021_02_13_429885	5	20	have	have	VBP
10_1101-2021_02_13_429885	5	21	been	be	VBN
10_1101-2021_02_13_429885	5	22	significantly	significantly	RB
10_1101-2021_02_13_429885	5	23	improved	improve	VBN
10_1101-2021_02_13_429885	5	24	with	with	IN
10_1101-2021_02_13_429885	5	25	the	the	DT
10_1101-2021_02_13_429885	5	26	introduction	introduction	NN
10_1101-2021_02_13_429885	5	27	of	of	IN
10_1101-2021_02_13_429885	5	28	whole	whole	JJ
10_1101-2021_02_13_429885	5	29	genome	genome	JJ
10_1101-2021_02_13_429885	5	30	sequencing	sequencing	NN
10_1101-2021_02_13_429885	5	31	.	.	.
10_1101-2021_02_13_429885	6	1	However	however	RB
10_1101-2021_02_13_429885	6	2	the	the	DT
10_1101-2021_02_13_429885	6	3	broad	broad	JJ
10_1101-2021_02_13_429885	6	4	applications	application	NNS
10_1101-2021_02_13_429885	6	5	of	of	IN
10_1101-2021_02_13_429885	6	6	this	this	DT
10_1101-2021_02_13_429885	6	7	technology	technology	NN
10_1101-2021_02_13_429885	6	8	come	come	VBP
10_1101-2021_02_13_429885	6	9	with	with	IN
10_1101-2021_02_13_429885	6	10	complications	complication	NNS
10_1101-2021_02_13_429885	6	11	.	.	.
10_1101-2021_02_13_429885	7	1	To	to	IN
10_1101-2021_02_13_429885	7	2	date	date	NN
10_1101-2021_02_13_429885	7	3	there	there	EX
10_1101-2021_02_13_429885	7	4	has	have	VBZ
10_1101-2021_02_13_429885	7	5	been	be	VBN
10_1101-2021_02_13_429885	7	6	very	very	RB
10_1101-2021_02_13_429885	7	7	little	little	JJ
10_1101-2021_02_13_429885	7	8	standardisation	standardisation	NN
10_1101-2021_02_13_429885	7	9	in	in	IN
10_1101-2021_02_13_429885	7	10	how	how	WRB
10_1101-2021_02_13_429885	7	11	data	datum	NNS
10_1101-2021_02_13_429885	7	12	quality	quality	NN
10_1101-2021_02_13_429885	7	13	is	be	VBZ
10_1101-2021_02_13_429885	7	14	assessed	assess	VBN
10_1101-2021_02_13_429885	7	15	,	,	,
10_1101-2021_02_13_429885	7	16	leading	lead	VBG
10_1101-2021_02_13_429885	7	17	to	to	IN
10_1101-2021_02_13_429885	7	18	inconsistencies	inconsistency	NNS
10_1101-2021_02_13_429885	7	19	in	in	IN
10_1101-2021_02_13_429885	7	20	analyses	analysis	NNS
10_1101-2021_02_13_429885	7	21	and	and	CC
10_1101-2021_02_13_429885	7	22	disparate	disparate	JJ
10_1101-2021_02_13_429885	7	23	conclusions	conclusion	NNS
10_1101-2021_02_13_429885	7	24	.	.	.
10_1101-2021_02_13_429885	8	1	Manual	manual	JJ
10_1101-2021_02_13_429885	8	2	checking	checking	NN
10_1101-2021_02_13_429885	8	3	and	and	CC
10_1101-2021_02_13_429885	8	4	complex	complex	JJ
10_1101-2021_02_13_429885	8	5	consensus	consensus	NN
10_1101-2021_02_13_429885	8	6	calling	call	VBG
10_1101-2021_02_13_429885	8	7	strategies	strategy	NNS
10_1101-2021_02_13_429885	8	8	often	often	RB
10_1101-2021_02_13_429885	8	9	do	do	VBP
10_1101-2021_02_13_429885	8	10	not	not	RB
10_1101-2021_02_13_429885	8	11	scale	scale	VB
10_1101-2021_02_13_429885	8	12	to	to	IN
10_1101-2021_02_13_429885	8	13	large	large	JJ
10_1101-2021_02_13_429885	8	14	sample	sample	NN
10_1101-2021_02_13_429885	8	15	numbers	number	NNS
10_1101-2021_02_13_429885	8	16	,	,	,
10_1101-2021_02_13_429885	8	17	which	which	WDT
10_1101-2021_02_13_429885	8	18	leads	lead	VBZ
10_1101-2021_02_13_429885	8	19	to	to	IN
10_1101-2021_02_13_429885	8	20	procedural	procedural	JJ
10_1101-2021_02_13_429885	8	21	bottlenecks	bottleneck	NNS
10_1101-2021_02_13_429885	8	22	.	.	.
10_1101-2021_02_13_429885	9	1	To	to	TO
10_1101-2021_02_13_429885	9	2	address	address	VB
10_1101-2021_02_13_429885	9	3	this	this	DT
10_1101-2021_02_13_429885	9	4	issue	issue	NN
10_1101-2021_02_13_429885	9	5	,	,	,
10_1101-2021_02_13_429885	9	6	we	-PRON-	PRP
10_1101-2021_02_13_429885	9	7	present	present	VBP
10_1101-2021_02_13_429885	9	8	a	a	DT
10_1101-2021_02_13_429885	9	9	quality	quality	NN
10_1101-2021_02_13_429885	9	10	control	control	NN
10_1101-2021_02_13_429885	9	11	method	method	NN
10_1101-2021_02_13_429885	9	12	that	that	WDT
10_1101-2021_02_13_429885	9	13	integrates	integrate	VBZ
10_1101-2021_02_13_429885	9	14	point	point	NN
10_1101-2021_02_13_429885	9	15	mutations	mutation	NNS
10_1101-2021_02_13_429885	9	16	,	,	,
10_1101-2021_02_13_429885	9	17	copy	copy	NN
10_1101-2021_02_13_429885	9	18	numbers	number	NNS
10_1101-2021_02_13_429885	9	19	,	,	,
10_1101-2021_02_13_429885	9	20	and	and	CC
10_1101-2021_02_13_429885	9	21	other	other	JJ
10_1101-2021_02_13_429885	9	22	metrics	metric	NNS
10_1101-2021_02_13_429885	9	23	into	into	IN
10_1101-2021_02_13_429885	9	24	a	a	DT
10_1101-2021_02_13_429885	9	25	single	single	JJ
10_1101-2021_02_13_429885	9	26	quantitative	quantitative	JJ
10_1101-2021_02_13_429885	9	27	score	score	NN
10_1101-2021_02_13_429885	9	28	.	.	.
10_1101-2021_02_13_429885	10	1	We	-PRON-	PRP
10_1101-2021_02_13_429885	10	2	demonstrate	demonstrate	VBP
10_1101-2021_02_13_429885	10	3	its	-PRON-	PRP$
10_1101-2021_02_13_429885	10	4	power	power	NN
10_1101-2021_02_13_429885	10	5	on	on	IN
10_1101-2021_02_13_429885	10	6	1,065	1,065	CD
10_1101-2021_02_13_429885	10	7	whole	whole	JJ
10_1101-2021_02_13_429885	10	8	-	-	HYPH
10_1101-2021_02_13_429885	10	9	genomes	genome	NNS
10_1101-2021_02_13_429885	10	10	from	from	IN
10_1101-2021_02_13_429885	10	11	a	a	DT
10_1101-2021_02_13_429885	10	12	large	large	JJ
10_1101-2021_02_13_429885	10	13	-	-	HYPH
10_1101-2021_02_13_429885	10	14	scale	scale	NN
10_1101-2021_02_13_429885	10	15	pan	pan	NN
10_1101-2021_02_13_429885	10	16	-	-	HYPH
10_1101-2021_02_13_429885	10	17	cancer	cancer	NN
10_1101-2021_02_13_429885	10	18	cohort	cohort	NN
10_1101-2021_02_13_429885	10	19	,	,	,
10_1101-2021_02_13_429885	10	20	and	and	CC
10_1101-2021_02_13_429885	10	21	on	on	IN
10_1101-2021_02_13_429885	10	22	multi	multi	JJ
10_1101-2021_02_13_429885	10	23	-	-	JJ
10_1101-2021_02_13_429885	10	24	region	region	JJ
10_1101-2021_02_13_429885	10	25	data	datum	NNS
10_1101-2021_02_13_429885	10	26	of	of	IN
10_1101-2021_02_13_429885	10	27	two	two	CD
10_1101-2021_02_13_429885	10	28	colorectal	colorectal	JJ
10_1101-2021_02_13_429885	10	29	cancer	cancer	NN
10_1101-2021_02_13_429885	10	30	patients	patient	NNS
10_1101-2021_02_13_429885	10	31	.	.	.
10_1101-2021_02_13_429885	11	1	We	-PRON-	PRP
10_1101-2021_02_13_429885	11	2	highlight	highlight	VBP
10_1101-2021_02_13_429885	11	3	how	how	WRB
10_1101-2021_02_13_429885	11	4	our	-PRON-	PRP$
10_1101-2021_02_13_429885	11	5	approach	approach	NN
10_1101-2021_02_13_429885	11	6	significantly	significantly	RB
10_1101-2021_02_13_429885	11	7	improves	improve	VBZ
10_1101-2021_02_13_429885	11	8	the	the	DT
10_1101-2021_02_13_429885	11	9	generation	generation	NN
10_1101-2021_02_13_429885	11	10	of	of	IN
10_1101-2021_02_13_429885	11	11	cancer	cancer	NN
10_1101-2021_02_13_429885	11	12	mutation	mutation	NN
10_1101-2021_02_13_429885	11	13	data	datum	NNS
10_1101-2021_02_13_429885	11	14	,	,	,
10_1101-2021_02_13_429885	11	15	providing	provide	VBG
10_1101-2021_02_13_429885	11	16	visualisations	visualisation	NNS
10_1101-2021_02_13_429885	11	17	for	for	IN
10_1101-2021_02_13_429885	11	18	cross	cross	NN
10_1101-2021_02_13_429885	11	19	-	-	JJ
10_1101-2021_02_13_429885	11	20	referencing	reference	VBG
10_1101-2021_02_13_429885	11	21	with	with	IN
10_1101-2021_02_13_429885	11	22	other	other	JJ
10_1101-2021_02_13_429885	11	23	analyses	analysis	NNS
10_1101-2021_02_13_429885	11	24	.	.	.
10_1101-2021_02_13_429885	12	1	Our	-PRON-	PRP$
10_1101-2021_02_13_429885	12	2	approach	approach	NN
10_1101-2021_02_13_429885	12	3	is	be	VBZ
10_1101-2021_02_13_429885	12	4	fully	fully	RB
10_1101-2021_02_13_429885	12	5	automated	automate	VBN
10_1101-2021_02_13_429885	12	6	,	,	,
10_1101-2021_02_13_429885	12	7	designed	design	VBN
10_1101-2021_02_13_429885	12	8	to	to	TO
10_1101-2021_02_13_429885	12	9	work	work	VB
10_1101-2021_02_13_429885	12	10	downstream	downstream	JJ
10_1101-2021_02_13_429885	12	11	of	of	IN
10_1101-2021_02_13_429885	12	12	any	any	DT
10_1101-2021_02_13_429885	12	13	bioinformatic	bioinformatic	JJ
10_1101-2021_02_13_429885	12	14	pipeline	pipeline	NN
10_1101-2021_02_13_429885	12	15	,	,	,
10_1101-2021_02_13_429885	12	16	and	and	CC
10_1101-2021_02_13_429885	12	17	can	can	MD
10_1101-2021_02_13_429885	12	18	automatise	automatise	VB
10_1101-2021_02_13_429885	12	19	tool	tool	NN
10_1101-2021_02_13_429885	12	20	parameterization	parameterization	NN
10_1101-2021_02_13_429885	12	21	paving	pave	VBG
10_1101-2021_02_13_429885	12	22	the	the	DT
10_1101-2021_02_13_429885	12	23	way	way	NN
10_1101-2021_02_13_429885	12	24	for	for	IN
10_1101-2021_02_13_429885	12	25	fast	fast	JJ
10_1101-2021_02_13_429885	12	26	computational	computational	JJ
10_1101-2021_02_13_429885	12	27	assessment	assessment	NN
10_1101-2021_02_13_429885	12	28	of	of	IN
10_1101-2021_02_13_429885	12	29	data	datum	NNS
10_1101-2021_02_13_429885	12	30	quality	quality	NN
10_1101-2021_02_13_429885	12	31	in	in	IN
10_1101-2021_02_13_429885	12	32	the	the	DT
10_1101-2021_02_13_429885	12	33	era	era	NN
10_1101-2021_02_13_429885	12	34	of	of	IN
10_1101-2021_02_13_429885	12	35	whole	whole	JJ
10_1101-2021_02_13_429885	12	36	genome	genome	JJ
10_1101-2021_02_13_429885	12	37	sequencing	sequencing	NN
10_1101-2021_02_13_429885	12	38	.	.	.
10_1101-2021_02_13_429885	13	1	Introduction	introduction	NN
10_1101-2021_02_13_429885	13	2	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	13	3	remains	remain	VBZ
10_1101-2021_02_13_429885	13	4	an	an	DT
10_1101-2021_02_13_429885	13	5	unsolved	unsolved	JJ
10_1101-2021_02_13_429885	13	6	problem	problem	NN
10_1101-2021_02_13_429885	13	7	,	,	,
10_1101-2021_02_13_429885	13	8	and	and	CC
10_1101-2021_02_13_429885	13	9	a	a	DT
10_1101-2021_02_13_429885	13	10	key	key	JJ
10_1101-2021_02_13_429885	13	11	factor	factor	NN
10_1101-2021_02_13_429885	13	12	is	be	VBZ
10_1101-2021_02_13_429885	13	13	that	that	IN
10_1101-2021_02_13_429885	13	14	tumours	tumour	NNS
10_1101-2021_02_13_429885	13	15	develop	develop	VBP
10_1101-2021_02_13_429885	13	16	as	as	IN
10_1101-2021_02_13_429885	13	17	heterogeneous	heterogeneous	JJ
10_1101-2021_02_13_429885	13	18	cellular	cellular	JJ
10_1101-2021_02_13_429885	13	19	populations	population	NNS
10_1101-2021_02_13_429885	13	20	​(Greaves	​(Greaves	NNPS
10_1101-2021_02_13_429885	13	21	and	and	CC
10_1101-2021_02_13_429885	13	22	Maley	Maley	NNP
10_1101-2021_02_13_429885	13	23	2012	2012	CD
10_1101-2021_02_13_429885	13	24	;	;	:
10_1101-2021_02_13_429885	13	25	McGranahan	McGranahan	NNP
10_1101-2021_02_13_429885	13	26	and	and	CC
10_1101-2021_02_13_429885	13	27	Swanton	Swanton	NNP
10_1101-2021_02_13_429885	13	28	2017	2017	CD
10_1101-2021_02_13_429885	13	29	,	,	,
10_1101-2021_02_13_429885	13	30	2015)​.	2015)​.	CD
10_1101-2021_02_13_429885	14	1	Cancer	cancer	NN
10_1101-2021_02_13_429885	14	2	genomes	genome	NNS
10_1101-2021_02_13_429885	14	3	can	can	MD
10_1101-2021_02_13_429885	14	4	harbour	harbour	VB
10_1101-2021_02_13_429885	14	5	multiple	multiple	JJ
10_1101-2021_02_13_429885	14	6	types	type	NNS
10_1101-2021_02_13_429885	14	7	of	of	IN
10_1101-2021_02_13_429885	14	8	mutations	mutation	NNS
10_1101-2021_02_13_429885	14	9	compared	compare	VBN
10_1101-2021_02_13_429885	14	10	to	to	IN
10_1101-2021_02_13_429885	14	11	healthy	healthy	JJ
10_1101-2021_02_13_429885	14	12	cells	cell	NNS
10_1101-2021_02_13_429885	14	13	​(Macintyre	​(Macintyre	NNP
10_1101-2021_02_13_429885	14	14	et	et	FW
10_1101-2021_02_13_429885	14	15	al	al	NNP
10_1101-2021_02_13_429885	14	16	.	.	.
10_1101-2021_02_13_429885	15	1	2018	2018	CD
10_1101-2021_02_13_429885	15	2	;	;	:
10_1101-2021_02_13_429885	15	3	Martincorena	Martincorena	NNP
10_1101-2021_02_13_429885	15	4	et	et	FW
10_1101-2021_02_13_429885	15	5	al	al	NNP
10_1101-2021_02_13_429885	15	6	.	.	.
10_1101-2021_02_13_429885	16	1	2018	2018	CD
10_1101-2021_02_13_429885	16	2	,	,	,
10_1101-2021_02_13_429885	16	3	2015	2015	CD
10_1101-2021_02_13_429885	16	4	;	;	:
10_1101-2021_02_13_429885	16	5	Nik	Nik	NNP
10_1101-2021_02_13_429885	16	6	-	-	HYPH
10_1101-2021_02_13_429885	16	7	Zainal	Zainal	NNP
10_1101-2021_02_13_429885	16	8	et	et	NNP
10_1101-2021_02_13_429885	16	9	al	al	NNP
10_1101-2021_02_13_429885	16	10	.	.	.
10_1101-2021_02_13_429885	17	1	2012)​	2012)​	CD
10_1101-2021_02_13_429885	17	2	,	,	,
10_1101-2021_02_13_429885	17	3	and	and	CC
10_1101-2021_02_13_429885	17	4	many	many	JJ
10_1101-2021_02_13_429885	17	5	of	of	IN
10_1101-2021_02_13_429885	17	6	these	these	DT
10_1101-2021_02_13_429885	17	7	events	event	NNS
10_1101-2021_02_13_429885	17	8	contribute	contribute	VBP
10_1101-2021_02_13_429885	17	9	to	to	IN
10_1101-2021_02_13_429885	17	10	the	the	DT
10_1101-2021_02_13_429885	17	11	pathogenesis	pathogenesis	NN
10_1101-2021_02_13_429885	17	12	of	of	IN
10_1101-2021_02_13_429885	17	13	the	the	DT
10_1101-2021_02_13_429885	17	14	disease	disease	NN
10_1101-2021_02_13_429885	17	15	,	,	,
10_1101-2021_02_13_429885	17	16	and	and	CC
10_1101-2021_02_13_429885	17	17	therapeutic	therapeutic	JJ
10_1101-2021_02_13_429885	17	18	resistance	resistance	NN
10_1101-2021_02_13_429885	17	19	.	.	.
10_1101-2021_02_13_429885	18	1	A	a	DT
10_1101-2021_02_13_429885	18	2	popular	popular	JJ
10_1101-2021_02_13_429885	18	3	design	design	NN
10_1101-2021_02_13_429885	18	4	of	of	IN
10_1101-2021_02_13_429885	18	5	studies	study	NNS
10_1101-2021_02_13_429885	18	6	intending	intend	VBG
10_1101-2021_02_13_429885	18	7	to	to	IN
10_1101-2021_02_13_429885	18	8	.CC	.CC	:
10_1101-2021_02_13_429885	18	9	-	-	:
10_1101-2021_02_13_429885	18	10	BY	by	IN
10_1101-2021_02_13_429885	18	11	-	-	HYPH
10_1101-2021_02_13_429885	18	12	NC	NC	NNP
10_1101-2021_02_13_429885	18	13	-	-	HYPH
10_1101-2021_02_13_429885	18	14	ND	ND	NNP
10_1101-2021_02_13_429885	18	15	4.0	4.0	CD
10_1101-2021_02_13_429885	18	16	International	International	NNP
10_1101-2021_02_13_429885	18	17	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	18	18	under	under	IN
10_1101-2021_02_13_429885	18	19	a	a	DT
10_1101-2021_02_13_429885	18	20	(	(	-LRB-
10_1101-2021_02_13_429885	18	21	which	which	WDT
10_1101-2021_02_13_429885	18	22	was	be	VBD
10_1101-2021_02_13_429885	18	23	not	not	RB
10_1101-2021_02_13_429885	18	24	certified	certify	VBN
10_1101-2021_02_13_429885	18	25	by	by	IN
10_1101-2021_02_13_429885	18	26	peer	peer	NN
10_1101-2021_02_13_429885	18	27	review	review	NN
10_1101-2021_02_13_429885	18	28	)	)	-RRB-
10_1101-2021_02_13_429885	18	29	is	be	VBZ
10_1101-2021_02_13_429885	18	30	the	the	DT
10_1101-2021_02_13_429885	18	31	author	author	NN
10_1101-2021_02_13_429885	18	32	/	/	SYM
10_1101-2021_02_13_429885	18	33	funder	funder	NN
10_1101-2021_02_13_429885	18	34	,	,	,
10_1101-2021_02_13_429885	18	35	who	who	WP
10_1101-2021_02_13_429885	18	36	has	have	VBZ
10_1101-2021_02_13_429885	18	37	granted	grant	VBN
10_1101-2021_02_13_429885	18	38	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	18	39	a	a	DT
10_1101-2021_02_13_429885	18	40	license	license	NN
10_1101-2021_02_13_429885	18	41	to	to	TO
10_1101-2021_02_13_429885	18	42	display	display	VB
10_1101-2021_02_13_429885	18	43	the	the	DT
10_1101-2021_02_13_429885	18	44	preprint	preprint	NN
10_1101-2021_02_13_429885	18	45	in	in	IN
10_1101-2021_02_13_429885	18	46	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	18	47	.	.	.
10_1101-2021_02_13_429885	19	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	19	2	is	be	VBZ
10_1101-2021_02_13_429885	19	3	made	make	VBN
10_1101-2021_02_13_429885	19	4	The	the	DT
10_1101-2021_02_13_429885	19	5	copyright	copyright	NN
10_1101-2021_02_13_429885	19	6	holder	holder	NN
10_1101-2021_02_13_429885	19	7	for	for	IN
10_1101-2021_02_13_429885	19	8	this	this	DT
10_1101-2021_02_13_429885	19	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	19	10	version	version	NN
10_1101-2021_02_13_429885	19	11	posted	post	VBD
10_1101-2021_02_13_429885	19	12	February	February	NNP
10_1101-2021_02_13_429885	19	13	13	13	CD
10_1101-2021_02_13_429885	19	14	,	,	,
10_1101-2021_02_13_429885	19	15	2021	2021	CD
10_1101-2021_02_13_429885	19	16	.	.	.
10_1101-2021_02_13_429885	19	17	;	;	:
10_1101-2021_02_13_429885	19	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	19	19	:	:	:
10_1101-2021_02_13_429885	19	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	19	21	preprint	preprint	NN
10_1101-2021_02_13_429885	19	22	mailto:gcaravagna@units.it	mailto:gcaravagna@units.it	VBZ
10_1101-2021_02_13_429885	19	23	https://paperpile.com/c/rqVmzs/Pf2t+5LH8+ZoHM	https://paperpile.com/c/rqVmzs/Pf2t+5LH8+ZoHM	NNP
10_1101-2021_02_13_429885	19	24	https://paperpile.com/c/rqVmzs/Pf2t+5LH8+ZoHM	https://paperpile.com/c/rqVmzs/Pf2t+5LH8+ZoHM	NNP
10_1101-2021_02_13_429885	19	25	https://paperpile.com/c/rqVmzs/P1Yv+uG2X+4mqr+bHGV	https://paperpile.com/c/rqVmzs/P1Yv+uG2X+4mqr+bHGV	NNP
10_1101-2021_02_13_429885	19	26	https://paperpile.com/c/rqVmzs/P1Yv+uG2X+4mqr+bHGV	https://paperpile.com/c/rqvmzs/p1yv+ug2x+4mqr+bhgv	NN
10_1101-2021_02_13_429885	19	27	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	19	28	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	19	29	Househam	Househam	NNP
10_1101-2021_02_13_429885	19	30	et	et	FW
10_1101-2021_02_13_429885	19	31	al	al	NNP
10_1101-2021_02_13_429885	19	32	.	.	.
10_1101-2021_02_13_429885	20	1	A	a	DT
10_1101-2021_02_13_429885	20	2	fully	fully	RB
10_1101-2021_02_13_429885	20	3	automated	automate	VBN
10_1101-2021_02_13_429885	20	4	approach	approach	NN
10_1101-2021_02_13_429885	20	5	for	for	IN
10_1101-2021_02_13_429885	20	6	quality	quality	NN
10_1101-2021_02_13_429885	20	7	control	control	NN
10_1101-2021_02_13_429885	20	8	of	of	IN
10_1101-2021_02_13_429885	20	9	cancer	cancer	NN
10_1101-2021_02_13_429885	20	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	20	11	in	in	IN
10_1101-2021_02_13_429885	20	12	the	the	DT
10_1101-2021_02_13_429885	20	13	era	era	NN
10_1101-2021_02_13_429885	20	14	of	of	IN
10_1101-2021_02_13_429885	20	15	high	high	JJ
10_1101-2021_02_13_429885	20	16	-	-	HYPH
10_1101-2021_02_13_429885	20	17	resolution	resolution	NN
10_1101-2021_02_13_429885	20	18	whole	whole	JJ
10_1101-2021_02_13_429885	20	19	genome	genome	JJ
10_1101-2021_02_13_429885	20	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	20	21	.	.	.
10_1101-2021_02_13_429885	21	1	understand	understand	VB
10_1101-2021_02_13_429885	21	2	tumour	tumour	NNP
10_1101-2021_02_13_429885	21	3	development	development	NN
10_1101-2021_02_13_429885	21	4	involves	involve	VBZ
10_1101-2021_02_13_429885	21	5	collecting	collect	VBG
10_1101-2021_02_13_429885	21	6	tumour	tumour	NN
10_1101-2021_02_13_429885	21	7	and	and	CC
10_1101-2021_02_13_429885	21	8	matched	match	VBN
10_1101-2021_02_13_429885	21	9	-	-	HYPH
10_1101-2021_02_13_429885	21	10	normal	normal	JJ
10_1101-2021_02_13_429885	21	11	biopsies	biopsy	NNS
10_1101-2021_02_13_429885	21	12	,	,	,
10_1101-2021_02_13_429885	21	13	and	and	CC
10_1101-2021_02_13_429885	21	14	generating	generate	VBG
10_1101-2021_02_13_429885	21	15	so	so	RB
10_1101-2021_02_13_429885	21	16	-	-	HYPH
10_1101-2021_02_13_429885	21	17	called	call	VBN
10_1101-2021_02_13_429885	21	18	“	"	``
10_1101-2021_02_13_429885	21	19	bulk	bulk	NN
10_1101-2021_02_13_429885	21	20	”	"	''
10_1101-2021_02_13_429885	21	21	DNA	dna	NN
10_1101-2021_02_13_429885	21	22	sequencing	sequencing	NN
10_1101-2021_02_13_429885	21	23	data	datum	NNS
10_1101-2021_02_13_429885	21	24	for	for	IN
10_1101-2021_02_13_429885	21	25	both	both	DT
10_1101-2021_02_13_429885	21	26	​(Barnell	​(Barnell	NNP
10_1101-2021_02_13_429885	21	27	et	et	FW
10_1101-2021_02_13_429885	21	28	al	al	NNP
10_1101-2021_02_13_429885	21	29	.	.	.
10_1101-2021_02_13_429885	22	1	2019)​.	2019)​.	CD
10_1101-2021_02_13_429885	23	1	Using	use	VBG
10_1101-2021_02_13_429885	23	2	bioinformatic	bioinformatic	JJ
10_1101-2021_02_13_429885	23	3	tools	tool	NNS
10_1101-2021_02_13_429885	23	4	to	to	TO
10_1101-2021_02_13_429885	23	5	cross	cross	VB
10_1101-2021_02_13_429885	23	6	reference	reference	NN
10_1101-2021_02_13_429885	23	7	the	the	DT
10_1101-2021_02_13_429885	23	8	normal	normal	JJ
10_1101-2021_02_13_429885	23	9	genome	genome	NN
10_1101-2021_02_13_429885	23	10	against	against	IN
10_1101-2021_02_13_429885	23	11	the	the	DT
10_1101-2021_02_13_429885	23	12	aberrant	aberrant	JJ
10_1101-2021_02_13_429885	23	13	one	one	CD
10_1101-2021_02_13_429885	23	14	,	,	,
10_1101-2021_02_13_429885	23	15	the	the	DT
10_1101-2021_02_13_429885	23	16	mutations	mutation	NNS
10_1101-2021_02_13_429885	23	17	and	and	CC
10_1101-2021_02_13_429885	23	18	heterogeneity	heterogeneity	NN
10_1101-2021_02_13_429885	23	19	thereof	thereof	RB
10_1101-2021_02_13_429885	23	20	found	find	VBN
10_1101-2021_02_13_429885	23	21	in	in	IN
10_1101-2021_02_13_429885	23	22	the	the	DT
10_1101-2021_02_13_429885	23	23	tumour	tumour	NN
10_1101-2021_02_13_429885	23	24	sample	sample	NN
10_1101-2021_02_13_429885	23	25	can	can	MD
10_1101-2021_02_13_429885	23	26	be	be	VB
10_1101-2021_02_13_429885	23	27	derived	derive	VBN
10_1101-2021_02_13_429885	23	28	and	and	CC
10_1101-2021_02_13_429885	23	29	used	use	VBN
10_1101-2021_02_13_429885	23	30	in	in	IN
10_1101-2021_02_13_429885	23	31	other	other	JJ
10_1101-2021_02_13_429885	23	32	analyses	analysis	NNS
10_1101-2021_02_13_429885	23	33	.	.	.
10_1101-2021_02_13_429885	24	1	These	these	DT
10_1101-2021_02_13_429885	24	2	analyses	analysis	NNS
10_1101-2021_02_13_429885	24	3	include	include	VBP
10_1101-2021_02_13_429885	24	4	,	,	,
10_1101-2021_02_13_429885	24	5	but	but	CC
10_1101-2021_02_13_429885	24	6	are	be	VBP
10_1101-2021_02_13_429885	24	7	not	not	RB
10_1101-2021_02_13_429885	24	8	limited	limit	VBN
10_1101-2021_02_13_429885	24	9	to	to	IN
10_1101-2021_02_13_429885	24	10	,	,	,
10_1101-2021_02_13_429885	24	11	driver	driver	VB
10_1101-2021_02_13_429885	24	12	mutation	mutation	NN
10_1101-2021_02_13_429885	24	13	identification	identification	NN
10_1101-2021_02_13_429885	24	14	​(Bailey	​(Bailey	NNP
10_1101-2021_02_13_429885	24	15	et	et	FW
10_1101-2021_02_13_429885	24	16	al	al	NNP
10_1101-2021_02_13_429885	24	17	.	.	.
10_1101-2021_02_13_429885	25	1	2018	2018	CD
10_1101-2021_02_13_429885	25	2	;	;	:
10_1101-2021_02_13_429885	25	3	Gonzalez	Gonzalez	NNP
10_1101-2021_02_13_429885	25	4	-	-	HYPH
10_1101-2021_02_13_429885	25	5	Perez	Perez	NNP
10_1101-2021_02_13_429885	25	6	et	et	NNP
10_1101-2021_02_13_429885	25	7	al	al	NNP
10_1101-2021_02_13_429885	25	8	.	.	.
10_1101-2021_02_13_429885	26	1	2013)​	2013)​	CD
10_1101-2021_02_13_429885	26	2	,	,	,
10_1101-2021_02_13_429885	26	3	which	which	WDT
10_1101-2021_02_13_429885	26	4	aims	aim	VBZ
10_1101-2021_02_13_429885	26	5	to	to	TO
10_1101-2021_02_13_429885	26	6	discern	discern	VB
10_1101-2021_02_13_429885	26	7	the	the	DT
10_1101-2021_02_13_429885	26	8	key	key	JJ
10_1101-2021_02_13_429885	26	9	aberrations	aberration	NNS
10_1101-2021_02_13_429885	26	10	that	that	WDT
10_1101-2021_02_13_429885	26	11	cause	cause	VBP
10_1101-2021_02_13_429885	26	12	a	a	DT
10_1101-2021_02_13_429885	26	13	tumour	tumour	NN
10_1101-2021_02_13_429885	26	14	to	to	TO
10_1101-2021_02_13_429885	26	15	grow	grow	VB
10_1101-2021_02_13_429885	26	16	,	,	,
10_1101-2021_02_13_429885	26	17	patient	patient	JJ
10_1101-2021_02_13_429885	26	18	clustering	clustering	NN
10_1101-2021_02_13_429885	26	19	,	,	,
10_1101-2021_02_13_429885	26	20	which	which	WDT
10_1101-2021_02_13_429885	26	21	aims	aim	VBZ
10_1101-2021_02_13_429885	26	22	to	to	TO
10_1101-2021_02_13_429885	26	23	identify	identify	VB
10_1101-2021_02_13_429885	26	24	treatment	treatment	NN
10_1101-2021_02_13_429885	26	25	groups	group	NNS
10_1101-2021_02_13_429885	26	26	with	with	IN
10_1101-2021_02_13_429885	26	27	similar	similar	JJ
10_1101-2021_02_13_429885	26	28	biological	biological	JJ
10_1101-2021_02_13_429885	26	29	characteristics	characteristic	NNS
10_1101-2021_02_13_429885	26	30	,	,	,
10_1101-2021_02_13_429885	26	31	and	and	CC
10_1101-2021_02_13_429885	26	32	evolutionary	evolutionary	JJ
10_1101-2021_02_13_429885	26	33	inference	inference	NN
10_1101-2021_02_13_429885	26	34	​(Gerstung	​(Gerstung	NNP
10_1101-2021_02_13_429885	26	35	et	et	NNP
10_1101-2021_02_13_429885	26	36	al	al	NNP
10_1101-2021_02_13_429885	26	37	.	.	.
10_1101-2021_02_13_429885	27	1	2020	2020	CD
10_1101-2021_02_13_429885	27	2	;	;	:
10_1101-2021_02_13_429885	27	3	Nik	Nik	NNP
10_1101-2021_02_13_429885	27	4	-	-	HYPH
10_1101-2021_02_13_429885	27	5	Zainal	Zainal	NNP
10_1101-2021_02_13_429885	27	6	et	et	NNP
10_1101-2021_02_13_429885	27	7	al	al	NNP
10_1101-2021_02_13_429885	27	8	.	.	.
10_1101-2021_02_13_429885	28	1	2012	2012	CD
10_1101-2021_02_13_429885	28	2	;	;	:
10_1101-2021_02_13_429885	28	3	Caravagna	Caravagna	NNP
10_1101-2021_02_13_429885	28	4	et	et	NNP
10_1101-2021_02_13_429885	28	5	al	al	NNP
10_1101-2021_02_13_429885	28	6	.	.	.
10_1101-2021_02_13_429885	29	1	2020)​	2020)​	CD
10_1101-2021_02_13_429885	29	2	,	,	,
10_1101-2021_02_13_429885	29	3	which	which	WDT
10_1101-2021_02_13_429885	29	4	informs	inform	VBZ
10_1101-2021_02_13_429885	29	5	us	-PRON-	PRP
10_1101-2021_02_13_429885	29	6	how	how	WRB
10_1101-2021_02_13_429885	29	7	a	a	DT
10_1101-2021_02_13_429885	29	8	particular	particular	JJ
10_1101-2021_02_13_429885	29	9	tumour	tumour	NN
10_1101-2021_02_13_429885	29	10	developed	develop	VBN
10_1101-2021_02_13_429885	29	11	from	from	IN
10_1101-2021_02_13_429885	29	12	normal	normal	JJ
10_1101-2021_02_13_429885	29	13	cells	cell	NNS
10_1101-2021_02_13_429885	29	14	.	.	.
10_1101-2021_02_13_429885	30	1	There	there	EX
10_1101-2021_02_13_429885	30	2	are	be	VBP
10_1101-2021_02_13_429885	30	3	several	several	JJ
10_1101-2021_02_13_429885	30	4	types	type	NNS
10_1101-2021_02_13_429885	30	5	of	of	IN
10_1101-2021_02_13_429885	30	6	mutations	mutation	NNS
10_1101-2021_02_13_429885	30	7	that	that	WDT
10_1101-2021_02_13_429885	30	8	we	-PRON-	PRP
10_1101-2021_02_13_429885	30	9	can	can	MD
10_1101-2021_02_13_429885	30	10	retrieve	retrieve	VB
10_1101-2021_02_13_429885	30	11	from	from	IN
10_1101-2021_02_13_429885	30	12	DNA	dna	NN
10_1101-2021_02_13_429885	30	13	sequencing	sequencing	NN
10_1101-2021_02_13_429885	30	14	data	datum	NNS
10_1101-2021_02_13_429885	30	15	(	(	-LRB-
10_1101-2021_02_13_429885	30	16	Campbell	Campbell	NNP
10_1101-2021_02_13_429885	30	17	et	et	NNP
10_1101-2021_02_13_429885	30	18	al	al	NNP
10_1101-2021_02_13_429885	30	19	.	.	.
10_1101-2021_02_13_429885	31	1	2020)​.	2020)​.	CD
10_1101-2021_02_13_429885	32	1	Broadly	broadly	RB
10_1101-2021_02_13_429885	32	2	these	these	DT
10_1101-2021_02_13_429885	32	3	can	can	MD
10_1101-2021_02_13_429885	32	4	be	be	VB
10_1101-2021_02_13_429885	32	5	categorized	categorize	VBN
10_1101-2021_02_13_429885	32	6	as	as	IN
10_1101-2021_02_13_429885	32	7	single	single	JJ
10_1101-2021_02_13_429885	32	8	nucleotide	nucleotide	JJ
10_1101-2021_02_13_429885	32	9	variants	variant	NNS
10_1101-2021_02_13_429885	32	10	(	(	-LRB-
10_1101-2021_02_13_429885	32	11	SNVs	SNVs	NNPS
10_1101-2021_02_13_429885	32	12	)	)	-RRB-
10_1101-2021_02_13_429885	32	13	,	,	,
10_1101-2021_02_13_429885	32	14	copy	copy	VBP
10_1101-2021_02_13_429885	32	15	number	number	NN
10_1101-2021_02_13_429885	32	16	alterations	alteration	NNS
10_1101-2021_02_13_429885	32	17	(	(	-LRB-
10_1101-2021_02_13_429885	32	18	CNAs	CNAs	NNP
10_1101-2021_02_13_429885	32	19	)	)	-RRB-
10_1101-2021_02_13_429885	32	20	and	and	CC
10_1101-2021_02_13_429885	32	21	other	other	JJ
10_1101-2021_02_13_429885	32	22	more	more	RBR
10_1101-2021_02_13_429885	32	23	complex	complex	JJ
10_1101-2021_02_13_429885	32	24	changes	change	NNS
10_1101-2021_02_13_429885	32	25	such	such	JJ
10_1101-2021_02_13_429885	32	26	as	as	IN
10_1101-2021_02_13_429885	32	27	structural	structural	JJ
10_1101-2021_02_13_429885	32	28	variants	variant	NNS
10_1101-2021_02_13_429885	32	29	​(Li	​(Li	NNP
10_1101-2021_02_13_429885	32	30	et	et	FW
10_1101-2021_02_13_429885	32	31	al	al	NNP
10_1101-2021_02_13_429885	32	32	.	.	.
10_1101-2021_02_13_429885	33	1	2020)​.	2020)​.	CD
10_1101-2021_02_13_429885	34	1	All	all	DT
10_1101-2021_02_13_429885	34	2	types	type	NNS
10_1101-2021_02_13_429885	34	3	of	of	IN
10_1101-2021_02_13_429885	34	4	mutations	mutation	NNS
10_1101-2021_02_13_429885	34	5	can	can	MD
10_1101-2021_02_13_429885	34	6	drive	drive	VB
10_1101-2021_02_13_429885	34	7	tumour	tumour	NN
10_1101-2021_02_13_429885	34	8	progression	progression	NN
10_1101-2021_02_13_429885	34	9	,	,	,
10_1101-2021_02_13_429885	34	10	and	and	CC
10_1101-2021_02_13_429885	34	11	are	be	VBP
10_1101-2021_02_13_429885	34	12	therefore	therefore	RB
10_1101-2021_02_13_429885	34	13	important	important	JJ
10_1101-2021_02_13_429885	34	14	entities	entity	NNS
10_1101-2021_02_13_429885	34	15	to	to	TO
10_1101-2021_02_13_429885	34	16	study	study	VB
10_1101-2021_02_13_429885	34	17	​(Kent	​(Kent	NNP
10_1101-2021_02_13_429885	34	18	and	and	CC
10_1101-2021_02_13_429885	34	19	Green	Green	NNP
10_1101-2021_02_13_429885	34	20	2017	2017	CD
10_1101-2021_02_13_429885	34	21	-	-	SYM
10_1101-2021_02_13_429885	34	22	4	4	CD
10_1101-2021_02_13_429885	34	23	;	;	:
10_1101-2021_02_13_429885	34	24	Levine	Levine	NNP
10_1101-2021_02_13_429885	34	25	,	,	,
10_1101-2021_02_13_429885	34	26	Jenkins	Jenkins	NNP
10_1101-2021_02_13_429885	34	27	,	,	,
10_1101-2021_02_13_429885	34	28	and	and	CC
10_1101-2021_02_13_429885	34	29	Copeland	Copeland	NNP
10_1101-2021_02_13_429885	34	30	2019)​.	2019)​.	CD
10_1101-2021_02_13_429885	35	1	Luckily	luckily	RB
10_1101-2021_02_13_429885	35	2	,	,	,
10_1101-2021_02_13_429885	35	3	the	the	DT
10_1101-2021_02_13_429885	35	4	steady	steady	JJ
10_1101-2021_02_13_429885	35	5	drop	drop	NN
10_1101-2021_02_13_429885	35	6	in	in	IN
10_1101-2021_02_13_429885	35	7	sequencing	sequence	VBG
10_1101-2021_02_13_429885	35	8	costs	cost	NNS
10_1101-2021_02_13_429885	35	9	is	be	VBZ
10_1101-2021_02_13_429885	35	10	fueling	fuel	VBG
10_1101-2021_02_13_429885	35	11	the	the	DT
10_1101-2021_02_13_429885	35	12	creation	creation	NN
10_1101-2021_02_13_429885	35	13	of	of	IN
10_1101-2021_02_13_429885	35	14	large	large	JJ
10_1101-2021_02_13_429885	35	15	amounts	amount	NNS
10_1101-2021_02_13_429885	35	16	of	of	IN
10_1101-2021_02_13_429885	35	17	data	datum	NNS
10_1101-2021_02_13_429885	35	18	,	,	,
10_1101-2021_02_13_429885	35	19	which	which	WDT
10_1101-2021_02_13_429885	35	20	are	be	VBP
10_1101-2021_02_13_429885	35	21	becoming	become	VBG
10_1101-2021_02_13_429885	35	22	increasingly	increasingly	RB
10_1101-2021_02_13_429885	35	23	available	available	JJ
10_1101-2021_02_13_429885	35	24	for	for	IN
10_1101-2021_02_13_429885	35	25	researchers	researcher	NNS
10_1101-2021_02_13_429885	35	26	to	to	TO
10_1101-2021_02_13_429885	35	27	access	access	VB
10_1101-2021_02_13_429885	35	28	through	through	IN
10_1101-2021_02_13_429885	35	29	public	public	JJ
10_1101-2021_02_13_429885	35	30	databases	database	NNS
10_1101-2021_02_13_429885	35	31	.	.	.
10_1101-2021_02_13_429885	36	1	Notably	notably	RB
10_1101-2021_02_13_429885	36	2	,	,	,
10_1101-2021_02_13_429885	36	3	we	-PRON-	PRP
10_1101-2021_02_13_429885	36	4	are	be	VBP
10_1101-2021_02_13_429885	36	5	entering	enter	VBG
10_1101-2021_02_13_429885	36	6	the	the	DT
10_1101-2021_02_13_429885	36	7	era	era	NN
10_1101-2021_02_13_429885	36	8	of	of	IN
10_1101-2021_02_13_429885	36	9	high	high	JJ
10_1101-2021_02_13_429885	36	10	-	-	HYPH
10_1101-2021_02_13_429885	36	11	resolution	resolution	NN
10_1101-2021_02_13_429885	36	12	whole	whole	RB
10_1101-2021_02_13_429885	36	13	-	-	HYPH
10_1101-2021_02_13_429885	36	14	genome	genome	RB
10_1101-2021_02_13_429885	36	15	sequencing	sequencing	NN
10_1101-2021_02_13_429885	36	16	(	(	-LRB-
10_1101-2021_02_13_429885	36	17	WGS	WGS	NNP
10_1101-2021_02_13_429885	36	18	)	)	-RRB-
10_1101-2021_02_13_429885	36	19	,	,	,
10_1101-2021_02_13_429885	36	20	a	a	DT
10_1101-2021_02_13_429885	36	21	technology	technology	NN
10_1101-2021_02_13_429885	36	22	that	that	WDT
10_1101-2021_02_13_429885	36	23	can	can	MD
10_1101-2021_02_13_429885	36	24	read	read	VB
10_1101-2021_02_13_429885	36	25	out	out	RP
10_1101-2021_02_13_429885	36	26	the	the	DT
10_1101-2021_02_13_429885	36	27	majority	majority	NN
10_1101-2021_02_13_429885	36	28	of	of	IN
10_1101-2021_02_13_429885	36	29	a	a	DT
10_1101-2021_02_13_429885	36	30	tumour	tumour	NN
10_1101-2021_02_13_429885	36	31	genome	genome	NN
10_1101-2021_02_13_429885	36	32	,	,	,
10_1101-2021_02_13_429885	36	33	providing	provide	VBG
10_1101-2021_02_13_429885	36	34	major	major	JJ
10_1101-2021_02_13_429885	36	35	improvements	improvement	NNS
10_1101-2021_02_13_429885	36	36	over	over	IN
10_1101-2021_02_13_429885	36	37	whole	whole	JJ
10_1101-2021_02_13_429885	36	38	-	-	HYPH
10_1101-2021_02_13_429885	36	39	exome	exome	NN
10_1101-2021_02_13_429885	36	40	counterparts	counterpart	NNS
10_1101-2021_02_13_429885	36	41	.	.	.
10_1101-2021_02_13_429885	37	1	Generating	generate	VBG
10_1101-2021_02_13_429885	37	2	some	some	DT
10_1101-2021_02_13_429885	37	3	of	of	IN
10_1101-2021_02_13_429885	37	4	these	these	DT
10_1101-2021_02_13_429885	37	5	data	datum	NNS
10_1101-2021_02_13_429885	37	6	,	,	,
10_1101-2021_02_13_429885	37	7	however	however	RB
10_1101-2021_02_13_429885	37	8	,	,	,
10_1101-2021_02_13_429885	37	9	poses	pose	VBZ
10_1101-2021_02_13_429885	37	10	challenges	challenge	NNS
10_1101-2021_02_13_429885	37	11	.	.	.
10_1101-2021_02_13_429885	38	1	While	while	IN
10_1101-2021_02_13_429885	38	2	SNVs	SNVs	NNPS
10_1101-2021_02_13_429885	38	3	are	be	VBP
10_1101-2021_02_13_429885	38	4	the	the	DT
10_1101-2021_02_13_429885	38	5	simplest	simple	JJS
10_1101-2021_02_13_429885	38	6	type	type	NN
10_1101-2021_02_13_429885	38	7	of	of	IN
10_1101-2021_02_13_429885	38	8	mutations	mutation	NNS
10_1101-2021_02_13_429885	38	9	to	to	TO
10_1101-2021_02_13_429885	38	10	detect	detect	VB
10_1101-2021_02_13_429885	38	11	using	use	VBG
10_1101-2021_02_13_429885	38	12	bioinformatic	bioinformatic	JJ
10_1101-2021_02_13_429885	38	13	analysis	analysis	NN
10_1101-2021_02_13_429885	38	14	and	and	CC
10_1101-2021_02_13_429885	38	15	perhaps	perhaps	RB
10_1101-2021_02_13_429885	38	16	have	have	VB
10_1101-2021_02_13_429885	38	17	the	the	DT
10_1101-2021_02_13_429885	38	18	most	most	RBS
10_1101-2021_02_13_429885	38	19	well	well	RB
10_1101-2021_02_13_429885	38	20	established	establish	VBN
10_1101-2021_02_13_429885	38	21	supporting	support	VBG
10_1101-2021_02_13_429885	38	22	tools	tool	NNS
10_1101-2021_02_13_429885	38	23	​(Li	​(li	CD
10_1101-2021_02_13_429885	38	24	et	et	FW
10_1101-2021_02_13_429885	38	25	al	al	NNP
10_1101-2021_02_13_429885	38	26	.	.	.
10_1101-2021_02_13_429885	39	1	2020)​	2020)​	CD
10_1101-2021_02_13_429885	39	2	,	,	,
10_1101-2021_02_13_429885	39	3	CNAs	cna	NNS
10_1101-2021_02_13_429885	39	4	are	be	VBP
10_1101-2021_02_13_429885	39	5	particularly	particularly	RB
10_1101-2021_02_13_429885	39	6	difficult	difficult	JJ
10_1101-2021_02_13_429885	39	7	to	to	TO
10_1101-2021_02_13_429885	39	8	call	call	VB
10_1101-2021_02_13_429885	39	9	since	since	IN
10_1101-2021_02_13_429885	39	10	the	the	DT
10_1101-2021_02_13_429885	39	11	baseline	baseline	NN
10_1101-2021_02_13_429885	39	12	ploidy	ploidy	NN
10_1101-2021_02_13_429885	39	13	of	of	IN
10_1101-2021_02_13_429885	39	14	the	the	DT
10_1101-2021_02_13_429885	39	15	tumour	tumour	NN
10_1101-2021_02_13_429885	39	16	(	(	-LRB-
10_1101-2021_02_13_429885	39	17	i.e.	i.e.	FW
10_1101-2021_02_13_429885	39	18	,	,	,
10_1101-2021_02_13_429885	39	19	the	the	DT
10_1101-2021_02_13_429885	39	20	number	number	NN
10_1101-2021_02_13_429885	39	21	of	of	IN
10_1101-2021_02_13_429885	39	22	chromosome	chromosome	NN
10_1101-2021_02_13_429885	39	23	copies	copy	NNS
10_1101-2021_02_13_429885	39	24	)	)	-RRB-
10_1101-2021_02_13_429885	39	25	is	be	VBZ
10_1101-2021_02_13_429885	39	26	usually	usually	RB
10_1101-2021_02_13_429885	39	27	unknown	unknown	JJ
10_1101-2021_02_13_429885	39	28	and	and	CC
10_1101-2021_02_13_429885	39	29	has	have	VBZ
10_1101-2021_02_13_429885	39	30	to	to	TO
10_1101-2021_02_13_429885	39	31	be	be	VB
10_1101-2021_02_13_429885	39	32	inferred	infer	VBN
10_1101-2021_02_13_429885	39	33	from	from	IN
10_1101-2021_02_13_429885	39	34	the	the	DT
10_1101-2021_02_13_429885	39	35	data	datum	NNS
10_1101-2021_02_13_429885	39	36	.	.	.
10_1101-2021_02_13_429885	40	1	CNAs	cna	NNS
10_1101-2021_02_13_429885	40	2	are	be	VBP
10_1101-2021_02_13_429885	40	3	important	important	JJ
10_1101-2021_02_13_429885	40	4	types	type	NNS
10_1101-2021_02_13_429885	40	5	of	of	IN
10_1101-2021_02_13_429885	40	6	cancer	cancer	NN
10_1101-2021_02_13_429885	40	7	mutations	mutation	NNS
10_1101-2021_02_13_429885	40	8	;	;	:
10_1101-2021_02_13_429885	40	9	large	large	JJ
10_1101-2021_02_13_429885	40	10	-	-	HYPH
10_1101-2021_02_13_429885	40	11	scale	scale	NN
10_1101-2021_02_13_429885	40	12	gain	gain	NN
10_1101-2021_02_13_429885	40	13	and	and	CC
10_1101-2021_02_13_429885	40	14	loss	loss	NN
10_1101-2021_02_13_429885	40	15	of	of	IN
10_1101-2021_02_13_429885	40	16	chromosome	chromosome	NN
10_1101-2021_02_13_429885	40	17	arms	arm	NNS
10_1101-2021_02_13_429885	40	18	or	or	CC
10_1101-2021_02_13_429885	40	19	sections	section	NNS
10_1101-2021_02_13_429885	40	20	of	of	IN
10_1101-2021_02_13_429885	40	21	arms	arm	NNS
10_1101-2021_02_13_429885	40	22	can	can	MD
10_1101-2021_02_13_429885	40	23	confer	confer	VB
10_1101-2021_02_13_429885	40	24	tumour	tumour	NN
10_1101-2021_02_13_429885	40	25	cells	cell	NNS
10_1101-2021_02_13_429885	40	26	with	with	IN
10_1101-2021_02_13_429885	40	27	large	large	JJ
10_1101-2021_02_13_429885	40	28	-	-	HYPH
10_1101-2021_02_13_429885	40	29	scale	scale	NN
10_1101-2021_02_13_429885	40	30	phenotypic	phenotypic	NN
10_1101-2021_02_13_429885	40	31	changes	change	NNS
10_1101-2021_02_13_429885	40	32	,	,	,
10_1101-2021_02_13_429885	40	33	and	and	CC
10_1101-2021_02_13_429885	40	34	are	be	VBP
10_1101-2021_02_13_429885	40	35	often	often	RB
10_1101-2021_02_13_429885	40	36	important	important	JJ
10_1101-2021_02_13_429885	40	37	clinical	clinical	JJ
10_1101-2021_02_13_429885	40	38	targets	target	NNS
10_1101-2021_02_13_429885	40	39	​(Gerstung	​(Gerstung	NNP
10_1101-2021_02_13_429885	40	40	et	et	FW
10_1101-2021_02_13_429885	40	41	al	al	NNP
10_1101-2021_02_13_429885	40	42	.	.	.
10_1101-2021_02_13_429885	41	1	2020	2020	CD
10_1101-2021_02_13_429885	41	2	;	;	:
10_1101-2021_02_13_429885	41	3	Watkins	Watkins	NNP
10_1101-2021_02_13_429885	41	4	et	et	NNP
10_1101-2021_02_13_429885	41	5	al	al	NNP
10_1101-2021_02_13_429885	41	6	.	.	.
10_1101-2021_02_13_429885	42	1	11	11	CD
10_1101-2021_02_13_429885	42	2	2020)​.	2020)​.	CD
10_1101-2021_02_13_429885	43	1	SNVs	snv	NNS
10_1101-2021_02_13_429885	43	2	and	and	CC
10_1101-2021_02_13_429885	43	3	CNAs	cna	NNS
10_1101-2021_02_13_429885	43	4	are	be	VBP
10_1101-2021_02_13_429885	43	5	intertwined	intertwine	VBN
10_1101-2021_02_13_429885	43	6	mutation	mutation	NN
10_1101-2021_02_13_429885	43	7	groups	group	NNS
10_1101-2021_02_13_429885	43	8	.	.	.
10_1101-2021_02_13_429885	44	1	They	-PRON-	PRP
10_1101-2021_02_13_429885	44	2	can	can	MD
10_1101-2021_02_13_429885	44	3	overlap	overlap	VB
10_1101-2021_02_13_429885	44	4	within	within	IN
10_1101-2021_02_13_429885	44	5	a	a	DT
10_1101-2021_02_13_429885	44	6	tumour	tumour	NN
10_1101-2021_02_13_429885	44	7	cell	cell	NN
10_1101-2021_02_13_429885	44	8	’s	’s	POS
10_1101-2021_02_13_429885	44	9	genome	genome	NN
10_1101-2021_02_13_429885	44	10	,	,	,
10_1101-2021_02_13_429885	44	11	meaning	mean	VBG
10_1101-2021_02_13_429885	44	12	the	the	DT
10_1101-2021_02_13_429885	44	13	number	number	NN
10_1101-2021_02_13_429885	44	14	of	of	IN
10_1101-2021_02_13_429885	44	15	copies	copy	NNS
10_1101-2021_02_13_429885	44	16	of	of	IN
10_1101-2021_02_13_429885	44	17	an	an	DT
10_1101-2021_02_13_429885	44	18	SNV	SNV	NNP
10_1101-2021_02_13_429885	44	19	can	can	MD
10_1101-2021_02_13_429885	44	20	be	be	VB
10_1101-2021_02_13_429885	44	21	amplified	amplify	VBN
10_1101-2021_02_13_429885	44	22	or	or	CC
10_1101-2021_02_13_429885	44	23	indeed	indeed	RB
10_1101-2021_02_13_429885	44	24	reduced	reduce	VBN
10_1101-2021_02_13_429885	44	25	by	by	IN
10_1101-2021_02_13_429885	44	26	CNAs	cna	NNS
10_1101-2021_02_13_429885	44	27	.	.	.
10_1101-2021_02_13_429885	45	1	This	this	DT
10_1101-2021_02_13_429885	45	2	depends	depend	VBZ
10_1101-2021_02_13_429885	45	3	on	on	IN
10_1101-2021_02_13_429885	45	4	the	the	DT
10_1101-2021_02_13_429885	45	5	ploidy	ploidy	NN
10_1101-2021_02_13_429885	45	6	of	of	IN
10_1101-2021_02_13_429885	45	7	the	the	DT
10_1101-2021_02_13_429885	45	8	genome	genome	JJ
10_1101-2021_02_13_429885	45	9	regions	region	NNS
10_1101-2021_02_13_429885	45	10	overlapping	overlap	VBG
10_1101-2021_02_13_429885	45	11	with	with	IN
10_1101-2021_02_13_429885	45	12	the	the	DT
10_1101-2021_02_13_429885	45	13	variants	variant	NNS
10_1101-2021_02_13_429885	45	14	.	.	.
10_1101-2021_02_13_429885	46	1	For	for	IN
10_1101-2021_02_13_429885	46	2	instance	instance	NN
10_1101-2021_02_13_429885	46	3	,	,	,
10_1101-2021_02_13_429885	46	4	for	for	IN
10_1101-2021_02_13_429885	46	5	a	a	DT
10_1101-2021_02_13_429885	46	6	clonal	clonal	JJ
10_1101-2021_02_13_429885	46	7	-	-	HYPH
10_1101-2021_02_13_429885	46	8	meaning	meaning	NN
10_1101-2021_02_13_429885	46	9	present	present	NN
10_1101-2021_02_13_429885	46	10	in	in	IN
10_1101-2021_02_13_429885	46	11	every	every	DT
10_1101-2021_02_13_429885	46	12	cell	cell	NN
10_1101-2021_02_13_429885	46	13	of	of	IN
10_1101-2021_02_13_429885	46	14	the	the	DT
10_1101-2021_02_13_429885	46	15	tumour	tumour	NN
10_1101-2021_02_13_429885	46	16	sample	sample	NN
10_1101-2021_02_13_429885	46	17	-	-	HYPH
10_1101-2021_02_13_429885	46	18	heterozygous	heterozygous	JJ
10_1101-2021_02_13_429885	46	19	SNV	SNV	NNP
10_1101-2021_02_13_429885	46	20	in	in	IN
10_1101-2021_02_13_429885	46	21	a	a	DT
10_1101-2021_02_13_429885	46	22	diploid	diploid	JJ
10_1101-2021_02_13_429885	46	23	tumour	tumour	NN
10_1101-2021_02_13_429885	46	24	genome	genome	NN
10_1101-2021_02_13_429885	46	25	the	the	DT
10_1101-2021_02_13_429885	46	26	expected	expect	VBN
10_1101-2021_02_13_429885	46	27	variant	variant	JJ
10_1101-2021_02_13_429885	46	28	allele	allele	NNP
10_1101-2021_02_13_429885	46	29	frequency	frequency	NN
10_1101-2021_02_13_429885	46	30	(	(	-LRB-
10_1101-2021_02_13_429885	46	31	VAF	VAF	NNP
10_1101-2021_02_13_429885	46	32	)	)	-RRB-
10_1101-2021_02_13_429885	46	33	is	be	VBZ
10_1101-2021_02_13_429885	46	34	50	50	CD
10_1101-2021_02_13_429885	46	35	%	%	NN
10_1101-2021_02_13_429885	46	36	(	(	-LRB-
10_1101-2021_02_13_429885	46	37	i.e.	i.e.	FW
10_1101-2021_02_13_429885	46	38	,	,	,
10_1101-2021_02_13_429885	46	39	half	half	NN
10_1101-2021_02_13_429885	46	40	of	of	IN
10_1101-2021_02_13_429885	46	41	the	the	DT
10_1101-2021_02_13_429885	46	42	reads	read	NNS
10_1101-2021_02_13_429885	46	43	from	from	IN
10_1101-2021_02_13_429885	46	44	tumour	tumour	NN
10_1101-2021_02_13_429885	46	45	cells	cell	NNS
10_1101-2021_02_13_429885	46	46	will	will	MD
10_1101-2021_02_13_429885	46	47	harbour	harbour	VB
10_1101-2021_02_13_429885	46	48	the	the	DT
10_1101-2021_02_13_429885	46	49	SNV	SNV	NNP
10_1101-2021_02_13_429885	46	50	)	)	-RRB-
10_1101-2021_02_13_429885	46	51	.	.	.
10_1101-2021_02_13_429885	47	1	Alternatively	alternatively	RB
10_1101-2021_02_13_429885	47	2	,	,	,
10_1101-2021_02_13_429885	47	3	if	if	IN
10_1101-2021_02_13_429885	47	4	each	each	DT
10_1101-2021_02_13_429885	47	5	chromosome	chromosome	NN
10_1101-2021_02_13_429885	47	6	is	be	VBZ
10_1101-2021_02_13_429885	47	7	present	present	JJ
10_1101-2021_02_13_429885	47	8	in	in	IN
10_1101-2021_02_13_429885	47	9	three	three	CD
10_1101-2021_02_13_429885	47	10	copies	copy	NNS
10_1101-2021_02_13_429885	47	11	(	(	-LRB-
10_1101-2021_02_13_429885	47	12	triploid	triploid	NNP
10_1101-2021_02_13_429885	47	13	)	)	-RRB-
10_1101-2021_02_13_429885	47	14	,	,	,
10_1101-2021_02_13_429885	47	15	the	the	DT
10_1101-2021_02_13_429885	47	16	expected	expect	VBN
10_1101-2021_02_13_429885	47	17	VAF	VAF	NNP
10_1101-2021_02_13_429885	47	18	is	be	VBZ
10_1101-2021_02_13_429885	47	19	33	33	CD
10_1101-2021_02_13_429885	47	20	%	%	NN
10_1101-2021_02_13_429885	47	21	-	-	,
10_1101-2021_02_13_429885	47	22	if	if	IN
10_1101-2021_02_13_429885	47	23	the	the	DT
10_1101-2021_02_13_429885	47	24	SNV	SNV	NNP
10_1101-2021_02_13_429885	47	25	occurred	occur	VBD
10_1101-2021_02_13_429885	47	26	after	after	IN
10_1101-2021_02_13_429885	47	27	the	the	DT
10_1101-2021_02_13_429885	47	28	amplification	amplification	NN
10_1101-2021_02_13_429885	47	29	-	-	,
10_1101-2021_02_13_429885	47	30	or	or	CC
10_1101-2021_02_13_429885	47	31	66	66	CD
10_1101-2021_02_13_429885	47	32	%	%	NN
10_1101-2021_02_13_429885	47	33	-	-	,
10_1101-2021_02_13_429885	47	34	if	if	IN
10_1101-2021_02_13_429885	47	35	the	the	DT
10_1101-2021_02_13_429885	47	36	SNV	SNV	NNP
10_1101-2021_02_13_429885	47	37	is	be	VBZ
10_1101-2021_02_13_429885	47	38	on	on	IN
10_1101-2021_02_13_429885	47	39	the	the	DT
10_1101-2021_02_13_429885	47	40	amplified	amplify	VBN
10_1101-2021_02_13_429885	47	41	chromosome	chromosome	NN
10_1101-2021_02_13_429885	47	42	and	and	CC
10_1101-2021_02_13_429885	47	43	occurred	occur	VBD
10_1101-2021_02_13_429885	47	44	before	before	IN
10_1101-2021_02_13_429885	47	45	the	the	DT
10_1101-2021_02_13_429885	47	46	amplification	amplification	NN
10_1101-2021_02_13_429885	47	47	.	.	.
10_1101-2021_02_13_429885	48	1	The	the	DT
10_1101-2021_02_13_429885	48	2	theoretical	theoretical	JJ
10_1101-2021_02_13_429885	48	3	.CC	.CC	:
10_1101-2021_02_13_429885	48	4	-	-	HYPH
10_1101-2021_02_13_429885	48	5	BY	by	IN
10_1101-2021_02_13_429885	48	6	-	-	HYPH
10_1101-2021_02_13_429885	48	7	NC	NC	NNP
10_1101-2021_02_13_429885	48	8	-	-	HYPH
10_1101-2021_02_13_429885	48	9	ND	ND	NNP
10_1101-2021_02_13_429885	48	10	4.0	4.0	CD
10_1101-2021_02_13_429885	48	11	International	International	NNP
10_1101-2021_02_13_429885	48	12	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	48	13	under	under	IN
10_1101-2021_02_13_429885	48	14	a	a	DT
10_1101-2021_02_13_429885	48	15	(	(	-LRB-
10_1101-2021_02_13_429885	48	16	which	which	WDT
10_1101-2021_02_13_429885	48	17	was	be	VBD
10_1101-2021_02_13_429885	48	18	not	not	RB
10_1101-2021_02_13_429885	48	19	certified	certify	VBN
10_1101-2021_02_13_429885	48	20	by	by	IN
10_1101-2021_02_13_429885	48	21	peer	peer	NN
10_1101-2021_02_13_429885	48	22	review	review	NN
10_1101-2021_02_13_429885	48	23	)	)	-RRB-
10_1101-2021_02_13_429885	48	24	is	be	VBZ
10_1101-2021_02_13_429885	48	25	the	the	DT
10_1101-2021_02_13_429885	48	26	author	author	NN
10_1101-2021_02_13_429885	48	27	/	/	SYM
10_1101-2021_02_13_429885	48	28	funder	funder	NN
10_1101-2021_02_13_429885	48	29	,	,	,
10_1101-2021_02_13_429885	48	30	who	who	WP
10_1101-2021_02_13_429885	48	31	has	have	VBZ
10_1101-2021_02_13_429885	48	32	granted	grant	VBN
10_1101-2021_02_13_429885	48	33	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	48	34	a	a	DT
10_1101-2021_02_13_429885	48	35	license	license	NN
10_1101-2021_02_13_429885	48	36	to	to	TO
10_1101-2021_02_13_429885	48	37	display	display	VB
10_1101-2021_02_13_429885	48	38	the	the	DT
10_1101-2021_02_13_429885	48	39	preprint	preprint	NN
10_1101-2021_02_13_429885	48	40	in	in	IN
10_1101-2021_02_13_429885	48	41	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	48	42	.	.	.
10_1101-2021_02_13_429885	49	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	49	2	is	be	VBZ
10_1101-2021_02_13_429885	49	3	made	make	VBN
10_1101-2021_02_13_429885	49	4	The	the	DT
10_1101-2021_02_13_429885	49	5	copyright	copyright	NN
10_1101-2021_02_13_429885	49	6	holder	holder	NN
10_1101-2021_02_13_429885	49	7	for	for	IN
10_1101-2021_02_13_429885	49	8	this	this	DT
10_1101-2021_02_13_429885	49	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	49	10	version	version	NN
10_1101-2021_02_13_429885	49	11	posted	post	VBD
10_1101-2021_02_13_429885	49	12	February	February	NNP
10_1101-2021_02_13_429885	49	13	13	13	CD
10_1101-2021_02_13_429885	49	14	,	,	,
10_1101-2021_02_13_429885	49	15	2021	2021	CD
10_1101-2021_02_13_429885	49	16	.	.	.
10_1101-2021_02_13_429885	49	17	;	;	:
10_1101-2021_02_13_429885	49	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	49	19	:	:	:
10_1101-2021_02_13_429885	49	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	49	21	preprint	preprint	NN
10_1101-2021_02_13_429885	49	22	https://paperpile.com/c/rqVmzs/j5j7	https://paperpile.com/c/rqVmzs/j5j7	NNP
10_1101-2021_02_13_429885	49	23	https://paperpile.com/c/rqVmzs/j5j7	https://paperpile.com/c/rqvmzs/j5j7	XX
10_1101-2021_02_13_429885	49	24	https://paperpile.com/c/rqVmzs/UEke+Glz6	https://paperpile.com/c/rqVmzs/UEke+Glz6	NNP
10_1101-2021_02_13_429885	49	25	https://paperpile.com/c/rqVmzs/vQgD+bHGV+chqB	https://paperpile.com/c/rqVmzs/vQgD+bHGV+chqB	NNP
10_1101-2021_02_13_429885	49	26	https://paperpile.com/c/rqVmzs/vQgD+bHGV+chqB	https://paperpile.com/c/rqVmzs/vQgD+bHGV+chqB	NNP
10_1101-2021_02_13_429885	49	27	https://paperpile.com/c/rqVmzs/CxXa	https://paperpile.com/c/rqVmzs/CxXa	NNP
10_1101-2021_02_13_429885	49	28	https://paperpile.com/c/rqVmzs/tMOu	https://paperpile.com/c/rqVmzs/tMOu	NNP
10_1101-2021_02_13_429885	49	29	https://paperpile.com/c/rqVmzs/df7V+SxXl	https://paperpile.com/c/rqVmzs/df7V+SxXl	:
10_1101-2021_02_13_429885	49	30	https://paperpile.com/c/rqVmzs/df7V+SxXl	https://paperpile.com/c/rqVmzs/df7V+SxXl	NNP
10_1101-2021_02_13_429885	49	31	https://paperpile.com/c/rqVmzs/tMOu	https://paperpile.com/c/rqVmzs/tMOu	NNP
10_1101-2021_02_13_429885	49	32	https://paperpile.com/c/rqVmzs/vQgD+NCPJ	https://paperpile.com/c/rqvmzs/vqgd+ncpj	ADD
10_1101-2021_02_13_429885	49	33	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	NNP
10_1101-2021_02_13_429885	49	34	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	49	35	Househam	Househam	NNP
10_1101-2021_02_13_429885	49	36	et	et	FW
10_1101-2021_02_13_429885	49	37	al	al	NNP
10_1101-2021_02_13_429885	49	38	.	.	.
10_1101-2021_02_13_429885	50	1	A	a	DT
10_1101-2021_02_13_429885	50	2	fully	fully	RB
10_1101-2021_02_13_429885	50	3	automated	automate	VBN
10_1101-2021_02_13_429885	50	4	approach	approach	NN
10_1101-2021_02_13_429885	50	5	for	for	IN
10_1101-2021_02_13_429885	50	6	quality	quality	NN
10_1101-2021_02_13_429885	50	7	control	control	NN
10_1101-2021_02_13_429885	50	8	of	of	IN
10_1101-2021_02_13_429885	50	9	cancer	cancer	NN
10_1101-2021_02_13_429885	50	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	50	11	in	in	IN
10_1101-2021_02_13_429885	50	12	the	the	DT
10_1101-2021_02_13_429885	50	13	era	era	NN
10_1101-2021_02_13_429885	50	14	of	of	IN
10_1101-2021_02_13_429885	50	15	high	high	JJ
10_1101-2021_02_13_429885	50	16	-	-	HYPH
10_1101-2021_02_13_429885	50	17	resolution	resolution	NN
10_1101-2021_02_13_429885	50	18	whole	whole	JJ
10_1101-2021_02_13_429885	50	19	genome	genome	JJ
10_1101-2021_02_13_429885	50	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	50	21	.	.	.
10_1101-2021_02_13_429885	51	1	frequencies	frequency	NNS
10_1101-2021_02_13_429885	51	2	are	be	VBP
10_1101-2021_02_13_429885	51	3	observed	observe	VBN
10_1101-2021_02_13_429885	51	4	with	with	IN
10_1101-2021_02_13_429885	51	5	a	a	DT
10_1101-2021_02_13_429885	51	6	Binomial	Binomial	NNP
10_1101-2021_02_13_429885	51	7	noise	noise	NN
10_1101-2021_02_13_429885	51	8	model	model	NN
10_1101-2021_02_13_429885	51	9	that	that	WDT
10_1101-2021_02_13_429885	51	10	depends	depend	VBZ
10_1101-2021_02_13_429885	51	11	on	on	IN
10_1101-2021_02_13_429885	51	12	the	the	DT
10_1101-2021_02_13_429885	51	13	depth	depth	NN
10_1101-2021_02_13_429885	51	14	of	of	IN
10_1101-2021_02_13_429885	51	15	sequencing	sequencing	NN
10_1101-2021_02_13_429885	51	16	and	and	CC
10_1101-2021_02_13_429885	51	17	the	the	DT
10_1101-2021_02_13_429885	51	18	actual	actual	JJ
10_1101-2021_02_13_429885	51	19	VAF	VAF	NNP
10_1101-2021_02_13_429885	51	20	​(Nik	​(nik	CD
10_1101-2021_02_13_429885	51	21	-	-	HYPH
10_1101-2021_02_13_429885	51	22	Zainal	Zainal	NNP
10_1101-2021_02_13_429885	51	23	et	et	NNP
10_1101-2021_02_13_429885	51	24	al	al	NNP
10_1101-2021_02_13_429885	51	25	.	.	.
10_1101-2021_02_13_429885	52	1	2012	2012	CD
10_1101-2021_02_13_429885	52	2	;	;	:
10_1101-2021_02_13_429885	52	3	Caravagna	Caravagna	NNP
10_1101-2021_02_13_429885	52	4	et	et	NNP
10_1101-2021_02_13_429885	52	5	al	al	NNP
10_1101-2021_02_13_429885	52	6	.	.	.
10_1101-2021_02_13_429885	53	1	2020)​.	2020)​.	CD
10_1101-2021_02_13_429885	54	1	We	-PRON-	PRP
10_1101-2021_02_13_429885	54	2	note	note	VBP
10_1101-2021_02_13_429885	54	3	that	that	IN
10_1101-2021_02_13_429885	54	4	these	these	DT
10_1101-2021_02_13_429885	54	5	VAFs	vaf	NNS
10_1101-2021_02_13_429885	54	6	hold	hold	VBP
10_1101-2021_02_13_429885	54	7	for	for	IN
10_1101-2021_02_13_429885	54	8	pure	pure	JJ
10_1101-2021_02_13_429885	54	9	bulk	bulk	JJ
10_1101-2021_02_13_429885	54	10	tumour	tumour	NN
10_1101-2021_02_13_429885	54	11	samples	sample	NNS
10_1101-2021_02_13_429885	54	12	(	(	-LRB-
10_1101-2021_02_13_429885	54	13	100	100	CD
10_1101-2021_02_13_429885	54	14	%	%	NN
10_1101-2021_02_13_429885	54	15	tumour	tumour	NN
10_1101-2021_02_13_429885	54	16	cells	cell	NNS
10_1101-2021_02_13_429885	54	17	)	)	-RRB-
10_1101-2021_02_13_429885	54	18	.	.	.
10_1101-2021_02_13_429885	55	1	Realistically	realistically	RB
10_1101-2021_02_13_429885	55	2	,	,	,
10_1101-2021_02_13_429885	55	3	most	most	JJS
10_1101-2021_02_13_429885	55	4	bulk	bulk	JJ
10_1101-2021_02_13_429885	55	5	samples	sample	NNS
10_1101-2021_02_13_429885	55	6	contain	contain	VBP
10_1101-2021_02_13_429885	55	7	normal	normal	JJ
10_1101-2021_02_13_429885	55	8	cells	cell	NNS
10_1101-2021_02_13_429885	55	9	,	,	,
10_1101-2021_02_13_429885	55	10	the	the	DT
10_1101-2021_02_13_429885	55	11	percentage	percentage	NN
10_1101-2021_02_13_429885	55	12	of	of	IN
10_1101-2021_02_13_429885	55	13	which	which	WDT
10_1101-2021_02_13_429885	55	14	shifts	shift	VBZ
10_1101-2021_02_13_429885	55	15	these	these	DT
10_1101-2021_02_13_429885	55	16	theoretical	theoretical	JJ
10_1101-2021_02_13_429885	55	17	frequencies	frequency	NNS
10_1101-2021_02_13_429885	55	18	towards	towards	IN
10_1101-2021_02_13_429885	55	19	lower	low	JJR
10_1101-2021_02_13_429885	55	20	values	value	NNS
10_1101-2021_02_13_429885	55	21	.	.	.
10_1101-2021_02_13_429885	56	1	These	these	DT
10_1101-2021_02_13_429885	56	2	ideas	idea	NNS
10_1101-2021_02_13_429885	56	3	are	be	VBP
10_1101-2021_02_13_429885	56	4	leveraged	leverage	VBN
10_1101-2021_02_13_429885	56	5	by	by	IN
10_1101-2021_02_13_429885	56	6	methods	method	NNS
10_1101-2021_02_13_429885	56	7	that	that	WDT
10_1101-2021_02_13_429885	56	8	seek	seek	VBP
10_1101-2021_02_13_429885	56	9	to	to	TO
10_1101-2021_02_13_429885	56	10	compute	compute	VB
10_1101-2021_02_13_429885	56	11	the	the	DT
10_1101-2021_02_13_429885	56	12	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	56	13	Cell	Cell	NNP
10_1101-2021_02_13_429885	56	14	Fractions	Fractions	NNPS
10_1101-2021_02_13_429885	56	15	(	(	-LRB-
10_1101-2021_02_13_429885	56	16	CCFs	CCFs	NNP
10_1101-2021_02_13_429885	56	17	)	)	-RRB-
10_1101-2021_02_13_429885	56	18	of	of	IN
10_1101-2021_02_13_429885	56	19	the	the	DT
10_1101-2021_02_13_429885	56	20	tumour	tumour	NN
10_1101-2021_02_13_429885	56	21	,	,	,
10_1101-2021_02_13_429885	56	22	i.e.	i.e.	FW
10_1101-2021_02_13_429885	56	23	,	,	,
10_1101-2021_02_13_429885	56	24	a	a	DT
10_1101-2021_02_13_429885	56	25	normalisation	normalisation	NN
10_1101-2021_02_13_429885	56	26	of	of	IN
10_1101-2021_02_13_429885	56	27	the	the	DT
10_1101-2021_02_13_429885	56	28	observed	observed	JJ
10_1101-2021_02_13_429885	56	29	tumour	tumour	NN
10_1101-2021_02_13_429885	56	30	VAF	VAF	NNP
10_1101-2021_02_13_429885	56	31	for	for	IN
10_1101-2021_02_13_429885	56	32	the	the	DT
10_1101-2021_02_13_429885	56	33	CNA	CNA	NNP
10_1101-2021_02_13_429885	56	34	,	,	,
10_1101-2021_02_13_429885	56	35	the	the	DT
10_1101-2021_02_13_429885	56	36	number	number	NN
10_1101-2021_02_13_429885	56	37	of	of	IN
10_1101-2021_02_13_429885	56	38	copies	copy	NNS
10_1101-2021_02_13_429885	56	39	of	of	IN
10_1101-2021_02_13_429885	56	40	a	a	DT
10_1101-2021_02_13_429885	56	41	mutation	mutation	NN
10_1101-2021_02_13_429885	56	42	(	(	-LRB-
10_1101-2021_02_13_429885	56	43	mutation	mutation	NN
10_1101-2021_02_13_429885	56	44	multiplicity	multiplicity	NN
10_1101-2021_02_13_429885	56	45	)	)	-RRB-
10_1101-2021_02_13_429885	56	46	and	and	CC
10_1101-2021_02_13_429885	56	47	tumour	tumour	VB
10_1101-2021_02_13_429885	56	48	purity	purity	NN
10_1101-2021_02_13_429885	56	49	​(Nik	​(Nik	NNP
10_1101-2021_02_13_429885	56	50	-	-	HYPH
10_1101-2021_02_13_429885	56	51	Zainal	Zainal	NNP
10_1101-2021_02_13_429885	56	52	et	et	NNP
10_1101-2021_02_13_429885	56	53	al	al	NNP
10_1101-2021_02_13_429885	56	54	.	.	.
10_1101-2021_02_13_429885	57	1	2012)​.	2012)​.	XX
10_1101-2021_02_13_429885	58	1	Many	many	JJ
10_1101-2021_02_13_429885	58	2	bioinformatics	bioinformatic	NNS
10_1101-2021_02_13_429885	58	3	pipelines	pipeline	NNS
10_1101-2021_02_13_429885	58	4	are	be	VBP
10_1101-2021_02_13_429885	58	5	designed	design	VBN
10_1101-2021_02_13_429885	58	6	to	to	TO
10_1101-2021_02_13_429885	58	7	start	start	VB
10_1101-2021_02_13_429885	58	8	from	from	IN
10_1101-2021_02_13_429885	58	9	a	a	DT
10_1101-2021_02_13_429885	58	10	BAM	bam	NN
10_1101-2021_02_13_429885	58	11	formatted	format	VBN
10_1101-2021_02_13_429885	58	12	input	input	NN
10_1101-2021_02_13_429885	58	13	file	file	NN
10_1101-2021_02_13_429885	58	14	and	and	CC
10_1101-2021_02_13_429885	58	15	,	,	,
10_1101-2021_02_13_429885	58	16	following	follow	VBG
10_1101-2021_02_13_429885	58	17	variant	variant	JJ
10_1101-2021_02_13_429885	58	18	calling	calling	NN
10_1101-2021_02_13_429885	58	19	,	,	,
10_1101-2021_02_13_429885	58	20	extract	extract	VB
10_1101-2021_02_13_429885	58	21	the	the	DT
10_1101-2021_02_13_429885	58	22	VAF	VAF	NNP
10_1101-2021_02_13_429885	58	23	of	of	IN
10_1101-2021_02_13_429885	58	24	mutations	mutation	NNS
10_1101-2021_02_13_429885	58	25	while	while	IN
10_1101-2021_02_13_429885	58	26	calling	call	VBG
10_1101-2021_02_13_429885	58	27	CNAs	cna	NNS
10_1101-2021_02_13_429885	58	28	in	in	IN
10_1101-2021_02_13_429885	58	29	parallel	parallel	NN
10_1101-2021_02_13_429885	58	30	(	(	-LRB-
10_1101-2021_02_13_429885	58	31	Boeva	Boeva	NNP
10_1101-2021_02_13_429885	58	32	et	et	NNP
10_1101-2021_02_13_429885	58	33	al	al	NNP
10_1101-2021_02_13_429885	58	34	.	.	.
10_1101-2021_02_13_429885	59	1	2011	2011	CD
10_1101-2021_02_13_429885	59	2	;	;	:
10_1101-2021_02_13_429885	59	3	Cmero	Cmero	NNP
10_1101-2021_02_13_429885	59	4	et	et	NNP
10_1101-2021_02_13_429885	59	5	al	al	NNP
10_1101-2021_02_13_429885	59	6	.	.	.
10_1101-2021_02_13_429885	60	1	2020	2020	CD
10_1101-2021_02_13_429885	60	2	;	;	:
10_1101-2021_02_13_429885	60	3	Zaccaria	Zaccaria	NNP
10_1101-2021_02_13_429885	60	4	and	and	CC
10_1101-2021_02_13_429885	60	5	Raphael	Raphael	NNP
10_1101-2021_02_13_429885	60	6	2020	2020	CD
10_1101-2021_02_13_429885	60	7	;	;	:
10_1101-2021_02_13_429885	60	8	Van	Van	NNP
10_1101-2021_02_13_429885	60	9	Loo	Loo	NNP
10_1101-2021_02_13_429885	60	10	et	et	FW
10_1101-2021_02_13_429885	60	11	al	al	NNP
10_1101-2021_02_13_429885	60	12	.	.	.
10_1101-2021_02_13_429885	61	1	2010)​.	2010)​.	CD
10_1101-2021_02_13_429885	62	1	These	these	DT
10_1101-2021_02_13_429885	62	2	analyses	analysis	NNS
10_1101-2021_02_13_429885	62	3	are	be	VBP
10_1101-2021_02_13_429885	62	4	nearly	nearly	RB
10_1101-2021_02_13_429885	62	5	always	always	RB
10_1101-2021_02_13_429885	62	6	decoupled	decouple	VBN
10_1101-2021_02_13_429885	62	7	,	,	,
10_1101-2021_02_13_429885	62	8	and	and	CC
10_1101-2021_02_13_429885	62	9	can	can	MD
10_1101-2021_02_13_429885	62	10	return	return	VB
10_1101-2021_02_13_429885	62	11	inconsistent	inconsistent	JJ
10_1101-2021_02_13_429885	62	12	variant	variant	JJ
10_1101-2021_02_13_429885	62	13	calls	call	NNS
10_1101-2021_02_13_429885	62	14	;	;	,
10_1101-2021_02_13_429885	62	15	i.e.	i.e.	FW
10_1101-2021_02_13_429885	62	16	,	,	,
10_1101-2021_02_13_429885	62	17	CNAs	cna	NNS
10_1101-2021_02_13_429885	62	18	and	and	CC
10_1101-2021_02_13_429885	62	19	purity	purity	NN
10_1101-2021_02_13_429885	62	20	that	that	WDT
10_1101-2021_02_13_429885	62	21	mismatch	mismatch	VBP
10_1101-2021_02_13_429885	62	22	the	the	DT
10_1101-2021_02_13_429885	62	23	empirical	empirical	JJ
10_1101-2021_02_13_429885	62	24	VAF	VAF	NNP
10_1101-2021_02_13_429885	62	25	from	from	IN
10_1101-2021_02_13_429885	62	26	the	the	DT
10_1101-2021_02_13_429885	62	27	BAMs	bam	NNS
10_1101-2021_02_13_429885	62	28	.	.	.
10_1101-2021_02_13_429885	63	1	Since	since	IN
10_1101-2021_02_13_429885	63	2	CNAs	cna	NNS
10_1101-2021_02_13_429885	63	3	and	and	CC
10_1101-2021_02_13_429885	63	4	purity	purity	NN
10_1101-2021_02_13_429885	63	5	are	be	VBP
10_1101-2021_02_13_429885	63	6	inferred	infer	VBN
10_1101-2021_02_13_429885	63	7	through	through	IN
10_1101-2021_02_13_429885	63	8	various	various	JJ
10_1101-2021_02_13_429885	63	9	measurements	measurement	NNS
10_1101-2021_02_13_429885	63	10	that	that	WDT
10_1101-2021_02_13_429885	63	11	are	be	VBP
10_1101-2021_02_13_429885	63	12	subject	subject	JJ
10_1101-2021_02_13_429885	63	13	to	to	IN
10_1101-2021_02_13_429885	63	14	noise	noise	NN
10_1101-2021_02_13_429885	63	15	-	-	HYPH
10_1101-2021_02_13_429885	63	16	i.e.	i.e.	FW
10_1101-2021_02_13_429885	63	17	,	,	,
10_1101-2021_02_13_429885	63	18	mutation	mutation	NN
10_1101-2021_02_13_429885	63	19	allele	allele	NNP
10_1101-2021_02_13_429885	63	20	ratios	ratio	NNS
10_1101-2021_02_13_429885	63	21	,	,	,
10_1101-2021_02_13_429885	63	22	tumour	tumour	NN
10_1101-2021_02_13_429885	63	23	-	-	HYPH
10_1101-2021_02_13_429885	63	24	normal	normal	JJ
10_1101-2021_02_13_429885	63	25	depth	depth	NN
10_1101-2021_02_13_429885	63	26	ratios	ratio	NNS
10_1101-2021_02_13_429885	63	27	and	and	CC
10_1101-2021_02_13_429885	63	28	B	b	NN
10_1101-2021_02_13_429885	63	29	-	-	HYPH
10_1101-2021_02_13_429885	63	30	allele	allele	NNP
10_1101-2021_02_13_429885	63	31	frequencies	frequency	NNS
10_1101-2021_02_13_429885	63	32	are	be	VBP
10_1101-2021_02_13_429885	63	33	prime	prime	JJ
10_1101-2021_02_13_429885	63	34	examples	example	NNS
10_1101-2021_02_13_429885	63	35	-	-	:
10_1101-2021_02_13_429885	63	36	they	-PRON-	PRP
10_1101-2021_02_13_429885	63	37	are	be	VBP
10_1101-2021_02_13_429885	63	38	the	the	DT
10_1101-2021_02_13_429885	63	39	most	most	RBS
10_1101-2021_02_13_429885	63	40	likely	likely	JJ
10_1101-2021_02_13_429885	63	41	cause	cause	NN
10_1101-2021_02_13_429885	63	42	of	of	IN
10_1101-2021_02_13_429885	63	43	error	error	NN
10_1101-2021_02_13_429885	63	44	.	.	.
10_1101-2021_02_13_429885	64	1	While	while	IN
10_1101-2021_02_13_429885	64	2	in	in	IN
10_1101-2021_02_13_429885	64	3	some	some	DT
10_1101-2021_02_13_429885	64	4	cases	case	NNS
10_1101-2021_02_13_429885	64	5	these	these	DT
10_1101-2021_02_13_429885	64	6	errors	error	NNS
10_1101-2021_02_13_429885	64	7	can	can	MD
10_1101-2021_02_13_429885	64	8	be	be	VB
10_1101-2021_02_13_429885	64	9	spotted	spot	VBN
10_1101-2021_02_13_429885	64	10	and	and	CC
10_1101-2021_02_13_429885	64	11	fixed	fix	VBN
10_1101-2021_02_13_429885	64	12	by	by	IN
10_1101-2021_02_13_429885	64	13	manual	manual	JJ
10_1101-2021_02_13_429885	64	14	intervention	intervention	NN
10_1101-2021_02_13_429885	64	15	,	,	,
10_1101-2021_02_13_429885	64	16	this	this	DT
10_1101-2021_02_13_429885	64	17	process	process	NN
10_1101-2021_02_13_429885	64	18	is	be	VBZ
10_1101-2021_02_13_429885	64	19	also	also	RB
10_1101-2021_02_13_429885	64	20	subject	subject	JJ
10_1101-2021_02_13_429885	64	21	to	to	IN
10_1101-2021_02_13_429885	64	22	inconsistencies	inconsistency	NNS
10_1101-2021_02_13_429885	64	23	in	in	IN
10_1101-2021_02_13_429885	64	24	the	the	DT
10_1101-2021_02_13_429885	64	25	absence	absence	NN
10_1101-2021_02_13_429885	64	26	of	of	IN
10_1101-2021_02_13_429885	64	27	a	a	DT
10_1101-2021_02_13_429885	64	28	proper	proper	JJ
10_1101-2021_02_13_429885	64	29	statistical	statistical	JJ
10_1101-2021_02_13_429885	64	30	framework	framework	NN
10_1101-2021_02_13_429885	64	31	,	,	,
10_1101-2021_02_13_429885	64	32	and	and	CC
10_1101-2021_02_13_429885	64	33	does	do	VBZ
10_1101-2021_02_13_429885	64	34	not	not	RB
10_1101-2021_02_13_429885	64	35	scale	scale	VB
10_1101-2021_02_13_429885	64	36	in	in	IN
10_1101-2021_02_13_429885	64	37	studies	study	NNS
10_1101-2021_02_13_429885	64	38	seeking	seek	VBG
10_1101-2021_02_13_429885	64	39	to	to	TO
10_1101-2021_02_13_429885	64	40	generate	generate	VB
10_1101-2021_02_13_429885	64	41	datasets	dataset	NNS
10_1101-2021_02_13_429885	64	42	with	with	IN
10_1101-2021_02_13_429885	64	43	millions	million	NNS
10_1101-2021_02_13_429885	64	44	of	of	IN
10_1101-2021_02_13_429885	64	45	data	datum	NNS
10_1101-2021_02_13_429885	64	46	points	point	NNS
10_1101-2021_02_13_429885	64	47	​(Campbell	​(Campbell	NNP
10_1101-2021_02_13_429885	64	48	et	et	FW
10_1101-2021_02_13_429885	64	49	al	al	NNP
10_1101-2021_02_13_429885	64	50	.	.	.
10_1101-2021_02_13_429885	65	1	2020	2020	CD
10_1101-2021_02_13_429885	65	2	;	;	:
10_1101-2021_02_13_429885	65	3	Priestley	Priestley	NNP
10_1101-2021_02_13_429885	65	4	et	et	NNP
10_1101-2021_02_13_429885	65	5	al	al	NNP
10_1101-2021_02_13_429885	65	6	.	.	.
10_1101-2021_02_13_429885	66	1	2019	2019	CD
10_1101-2021_02_13_429885	66	2	;	;	:
10_1101-2021_02_13_429885	66	3	Turnbull	Turnbull	NNP
10_1101-2021_02_13_429885	66	4	et	et	FW
10_1101-2021_02_13_429885	66	5	al	al	NNP
10_1101-2021_02_13_429885	66	6	.	.	.
10_1101-2021_02_13_429885	67	1	2018)​.	2018)​.	CD
10_1101-2021_02_13_429885	68	1	The	the	DT
10_1101-2021_02_13_429885	68	2	intrinsic	intrinsic	JJ
10_1101-2021_02_13_429885	68	3	performance	performance	NN
10_1101-2021_02_13_429885	68	4	of	of	IN
10_1101-2021_02_13_429885	68	5	a	a	DT
10_1101-2021_02_13_429885	68	6	variant	variant	JJ
10_1101-2021_02_13_429885	68	7	caller	caller	NN
10_1101-2021_02_13_429885	68	8	and	and	CC
10_1101-2021_02_13_429885	68	9	sequencing	sequencing	NN
10_1101-2021_02_13_429885	68	10	noise	noise	NN
10_1101-2021_02_13_429885	68	11	therefore	therefore	RB
10_1101-2021_02_13_429885	68	12	massively	massively	RB
10_1101-2021_02_13_429885	68	13	impacts	impact	VBZ
10_1101-2021_02_13_429885	68	14	CNA	cna	NN
10_1101-2021_02_13_429885	68	15	calling	calling	NN
10_1101-2021_02_13_429885	68	16	and	and	CC
10_1101-2021_02_13_429885	68	17	purity	purity	NN
10_1101-2021_02_13_429885	68	18	inferences	inference	NNS
10_1101-2021_02_13_429885	68	19	,	,	,
10_1101-2021_02_13_429885	68	20	propagating	propagate	VBG
10_1101-2021_02_13_429885	68	21	errors	error	NNS
10_1101-2021_02_13_429885	68	22	in	in	IN
10_1101-2021_02_13_429885	68	23	downstream	downstream	JJ
10_1101-2021_02_13_429885	68	24	analysis	analysis	NN
10_1101-2021_02_13_429885	68	25	that	that	WDT
10_1101-2021_02_13_429885	68	26	eventually	eventually	RB
10_1101-2021_02_13_429885	68	27	lead	lead	VBP
10_1101-2021_02_13_429885	68	28	to	to	IN
10_1101-2021_02_13_429885	68	29	incorrect	incorrect	JJ
10_1101-2021_02_13_429885	68	30	biological	biological	JJ
10_1101-2021_02_13_429885	68	31	conclusions	conclusion	NNS
10_1101-2021_02_13_429885	68	32	,	,	,
10_1101-2021_02_13_429885	68	33	becoming	become	VBG
10_1101-2021_02_13_429885	68	34	a	a	DT
10_1101-2021_02_13_429885	68	35	crucial	crucial	JJ
10_1101-2021_02_13_429885	68	36	computational	computational	JJ
10_1101-2021_02_13_429885	68	37	bottleneck	bottleneck	NN
10_1101-2021_02_13_429885	68	38	in	in	IN
10_1101-2021_02_13_429885	68	39	the	the	DT
10_1101-2021_02_13_429885	68	40	era	era	NN
10_1101-2021_02_13_429885	68	41	of	of	IN
10_1101-2021_02_13_429885	68	42	high	high	JJ
10_1101-2021_02_13_429885	68	43	-	-	HYPH
10_1101-2021_02_13_429885	68	44	resolution	resolution	NN
10_1101-2021_02_13_429885	68	45	whole	whole	RB
10_1101-2021_02_13_429885	68	46	-	-	HYPH
10_1101-2021_02_13_429885	68	47	genome	genome	RB
10_1101-2021_02_13_429885	68	48	sequencing	sequencing	NN
10_1101-2021_02_13_429885	68	49	.	.	.
10_1101-2021_02_13_429885	69	1	To	to	TO
10_1101-2021_02_13_429885	69	2	solve	solve	VB
10_1101-2021_02_13_429885	69	3	these	these	DT
10_1101-2021_02_13_429885	69	4	problems	problem	NNS
10_1101-2021_02_13_429885	69	5	we	-PRON-	PRP
10_1101-2021_02_13_429885	69	6	developed	develop	VBD
10_1101-2021_02_13_429885	69	7	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	69	8	(	(	-LRB-
10_1101-2021_02_13_429885	69	9	​Data	​Data	NNP
10_1101-2021_02_13_429885	69	10	Availability​	Availability​	NNP
10_1101-2021_02_13_429885	69	11	)	)	-RRB-
10_1101-2021_02_13_429885	69	12	,	,	,
10_1101-2021_02_13_429885	69	13	a	a	DT
10_1101-2021_02_13_429885	69	14	computational	computational	JJ
10_1101-2021_02_13_429885	69	15	framework	framework	NN
10_1101-2021_02_13_429885	69	16	with	with	IN
10_1101-2021_02_13_429885	69	17	a	a	DT
10_1101-2021_02_13_429885	69	18	de	de	FW
10_1101-2021_02_13_429885	69	19	novo	novo	NNP
10_1101-2021_02_13_429885	69	20	statistical	statistical	JJ
10_1101-2021_02_13_429885	69	21	model	model	NN
10_1101-2021_02_13_429885	69	22	to	to	TO
10_1101-2021_02_13_429885	69	23	assess	assess	VB
10_1101-2021_02_13_429885	69	24	the	the	DT
10_1101-2021_02_13_429885	69	25	conformance	conformance	NN
10_1101-2021_02_13_429885	69	26	of	of	IN
10_1101-2021_02_13_429885	69	27	expected	expect	VBN
10_1101-2021_02_13_429885	69	28	SNVs	SNVs	NNPS
10_1101-2021_02_13_429885	69	29	,	,	,
10_1101-2021_02_13_429885	69	30	CNAs	cna	NNS
10_1101-2021_02_13_429885	69	31	,	,	,
10_1101-2021_02_13_429885	69	32	and	and	CC
10_1101-2021_02_13_429885	69	33	purity	purity	NN
10_1101-2021_02_13_429885	69	34	estimates	estimate	NNS
10_1101-2021_02_13_429885	69	35	.	.	.
10_1101-2021_02_13_429885	70	1	We	-PRON-	PRP
10_1101-2021_02_13_429885	70	2	strived	strive	VBD
10_1101-2021_02_13_429885	70	3	to	to	TO
10_1101-2021_02_13_429885	70	4	make	make	VB
10_1101-2021_02_13_429885	70	5	the	the	DT
10_1101-2021_02_13_429885	70	6	tool	tool	NN
10_1101-2021_02_13_429885	70	7	as	as	IN
10_1101-2021_02_13_429885	70	8	simple	simple	JJ
10_1101-2021_02_13_429885	70	9	to	to	TO
10_1101-2021_02_13_429885	70	10	implement	implement	VB
10_1101-2021_02_13_429885	70	11	as	as	IN
10_1101-2021_02_13_429885	70	12	possible	possible	JJ
10_1101-2021_02_13_429885	70	13	,	,	,
10_1101-2021_02_13_429885	70	14	maximising	maximise	VBG
10_1101-2021_02_13_429885	70	15	compatibility	compatibility	NN
10_1101-2021_02_13_429885	70	16	across	across	IN
10_1101-2021_02_13_429885	70	17	differing	differ	VBG
10_1101-2021_02_13_429885	70	18	pipelines	pipeline	NNS
10_1101-2021_02_13_429885	70	19	.	.	.
10_1101-2021_02_13_429885	71	1	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	71	2	computes	compute	VBZ
10_1101-2021_02_13_429885	71	3	a	a	DT
10_1101-2021_02_13_429885	71	4	quantitative	quantitative	JJ
10_1101-2021_02_13_429885	71	5	quality	quality	NN
10_1101-2021_02_13_429885	71	6	check	check	NN
10_1101-2021_02_13_429885	71	7	(	(	-LRB-
10_1101-2021_02_13_429885	71	8	QC	QC	NNP
10_1101-2021_02_13_429885	71	9	)	)	-RRB-
10_1101-2021_02_13_429885	71	10	score	score	VB
10_1101-2021_02_13_429885	71	11	for	for	IN
10_1101-2021_02_13_429885	71	12	the	the	DT
10_1101-2021_02_13_429885	71	13	overall	overall	JJ
10_1101-2021_02_13_429885	71	14	agreement	agreement	NN
10_1101-2021_02_13_429885	71	15	of	of	IN
10_1101-2021_02_13_429885	71	16	the	the	DT
10_1101-2021_02_13_429885	71	17	calls	call	NNS
10_1101-2021_02_13_429885	71	18	,	,	,
10_1101-2021_02_13_429885	71	19	which	which	WDT
10_1101-2021_02_13_429885	71	20	can	can	MD
10_1101-2021_02_13_429885	71	21	be	be	VB
10_1101-2021_02_13_429885	71	22	used	use	VBN
10_1101-2021_02_13_429885	71	23	to	to	TO
10_1101-2021_02_13_429885	71	24	tune	tune	VB
10_1101-2021_02_13_429885	71	25	the	the	DT
10_1101-2021_02_13_429885	71	26	parameters	parameter	NNS
10_1101-2021_02_13_429885	71	27	of	of	IN
10_1101-2021_02_13_429885	71	28	callers	caller	NNS
10_1101-2021_02_13_429885	71	29	(	(	-LRB-
10_1101-2021_02_13_429885	71	30	e.g.	e.g.	RB
10_1101-2021_02_13_429885	71	31	,	,	,
10_1101-2021_02_13_429885	71	32	decrease	decrease	VB
10_1101-2021_02_13_429885	71	33	purity	purity	NN
10_1101-2021_02_13_429885	71	34	or	or	CC
10_1101-2021_02_13_429885	71	35	increase	increase	VB
10_1101-2021_02_13_429885	71	36	ploidy	ploidy	NN
10_1101-2021_02_13_429885	71	37	)	)	-RRB-
10_1101-2021_02_13_429885	71	38	,	,	,
10_1101-2021_02_13_429885	71	39	or	or	CC
10_1101-2021_02_13_429885	71	40	select	select	VB
10_1101-2021_02_13_429885	71	41	among	among	IN
10_1101-2021_02_13_429885	71	42	multiple	multiple	JJ
10_1101-2021_02_13_429885	71	43	CNA	CNA	NNP
10_1101-2021_02_13_429885	71	44	profiles	profile	NNS
10_1101-2021_02_13_429885	71	45	(	(	-LRB-
10_1101-2021_02_13_429885	71	46	e.g.	e.g.	RB
10_1101-2021_02_13_429885	71	47	,	,	,
10_1101-2021_02_13_429885	71	48	tetraploid	tetraploid	NN
10_1101-2021_02_13_429885	71	49	versus	versus	IN
10_1101-2021_02_13_429885	71	50	diploid	diploid	NNP
10_1101-2021_02_13_429885	71	51	tumours	tumour	NNS
10_1101-2021_02_13_429885	71	52	)	)	-RRB-
10_1101-2021_02_13_429885	71	53	until	until	IN
10_1101-2021_02_13_429885	71	54	a	a	DT
10_1101-2021_02_13_429885	71	55	fit	fit	NN
10_1101-2021_02_13_429885	71	56	is	be	VBZ
10_1101-2021_02_13_429885	71	57	achieved	achieve	VBN
10_1101-2021_02_13_429885	71	58	.	.	.
10_1101-2021_02_13_429885	72	1	In	in	IN
10_1101-2021_02_13_429885	72	2	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	72	3	we	-PRON-	PRP
10_1101-2021_02_13_429885	72	4	also	also	RB
10_1101-2021_02_13_429885	72	5	integrate	integrate	VBP
10_1101-2021_02_13_429885	72	6	these	these	DT
10_1101-2021_02_13_429885	72	7	measures	measure	NNS
10_1101-2021_02_13_429885	72	8	to	to	TO
10_1101-2021_02_13_429885	72	9	determine	determine	VB
10_1101-2021_02_13_429885	72	10	CCF	ccf	NN
10_1101-2021_02_13_429885	72	11	values	value	NNS
10_1101-2021_02_13_429885	72	12	(	(	-LRB-
10_1101-2021_02_13_429885	72	13	Dentro	Dentro	NNP
10_1101-2021_02_13_429885	72	14	,	,	,
10_1101-2021_02_13_429885	72	15	Wedge	Wedge	NNP
10_1101-2021_02_13_429885	72	16	,	,	,
10_1101-2021_02_13_429885	72	17	and	and	CC
10_1101-2021_02_13_429885	72	18	Van	Van	NNP
10_1101-2021_02_13_429885	72	19	Loo	Loo	NNP
10_1101-2021_02_13_429885	72	20	2017)​.	2017)​.	CD
10_1101-2021_02_13_429885	73	1	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	73	2	is	be	VBZ
10_1101-2021_02_13_429885	73	3	implemented	implement	VBN
10_1101-2021_02_13_429885	73	4	as	as	IN
10_1101-2021_02_13_429885	73	5	a	a	DT
10_1101-2021_02_13_429885	73	6	highly	highly	RB
10_1101-2021_02_13_429885	73	7	optimised	optimised	JJ
10_1101-2021_02_13_429885	73	8	R	r	NN
10_1101-2021_02_13_429885	73	9	package	package	NN
10_1101-2021_02_13_429885	73	10	that	that	WDT
10_1101-2021_02_13_429885	73	11	can	can	MD
10_1101-2021_02_13_429885	73	12	be	be	VB
10_1101-2021_02_13_429885	73	13	used	use	VBN
10_1101-2021_02_13_429885	73	14	downstream	downstream	JJ
10_1101-2021_02_13_429885	73	15	of	of	IN
10_1101-2021_02_13_429885	73	16	any	any	DT
10_1101-2021_02_13_429885	73	17	cancer	cancer	NN
10_1101-2021_02_13_429885	73	18	mutation	mutation	NN
10_1101-2021_02_13_429885	73	19	calling	calling	NN
10_1101-2021_02_13_429885	73	20	pipeline	pipeline	NN
10_1101-2021_02_13_429885	73	21	.	.	.
10_1101-2021_02_13_429885	74	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	74	2	can	can	MD
10_1101-2021_02_13_429885	74	3	be	be	VB
10_1101-2021_02_13_429885	74	4	run	run	VBN
10_1101-2021_02_13_429885	74	5	on	on	IN
10_1101-2021_02_13_429885	74	6	WGS	WGS	NNP
10_1101-2021_02_13_429885	74	7	data	datum	NNS
10_1101-2021_02_13_429885	74	8	,	,	,
10_1101-2021_02_13_429885	74	9	and	and	CC
10_1101-2021_02_13_429885	74	10	can	can	MD
10_1101-2021_02_13_429885	74	11	automatically	automatically	RB
10_1101-2021_02_13_429885	74	12	compute	compute	VB
10_1101-2021_02_13_429885	74	13	a	a	DT
10_1101-2021_02_13_429885	74	14	QC	QC	NNP
10_1101-2021_02_13_429885	74	15	score	score	NN
10_1101-2021_02_13_429885	74	16	in	in	IN
10_1101-2021_02_13_429885	74	17	a	a	DT
10_1101-2021_02_13_429885	74	18	matter	matter	NN
10_1101-2021_02_13_429885	74	19	of	of	IN
10_1101-2021_02_13_429885	74	20	seconds	second	NNS
10_1101-2021_02_13_429885	74	21	,	,	,
10_1101-2021_02_13_429885	74	22	which	which	WDT
10_1101-2021_02_13_429885	74	23	is	be	VBZ
10_1101-2021_02_13_429885	74	24	an	an	DT
10_1101-2021_02_13_429885	74	25	extremely	extremely	RB
10_1101-2021_02_13_429885	74	26	useful	useful	JJ
10_1101-2021_02_13_429885	74	27	.CC	.CC	NFP
10_1101-2021_02_13_429885	74	28	-	-	HYPH
10_1101-2021_02_13_429885	74	29	BY	by	IN
10_1101-2021_02_13_429885	74	30	-	-	HYPH
10_1101-2021_02_13_429885	74	31	NC	NC	NNP
10_1101-2021_02_13_429885	74	32	-	-	HYPH
10_1101-2021_02_13_429885	74	33	ND	ND	NNP
10_1101-2021_02_13_429885	74	34	4.0	4.0	CD
10_1101-2021_02_13_429885	74	35	International	International	NNP
10_1101-2021_02_13_429885	74	36	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	74	37	under	under	IN
10_1101-2021_02_13_429885	74	38	a	a	DT
10_1101-2021_02_13_429885	74	39	(	(	-LRB-
10_1101-2021_02_13_429885	74	40	which	which	WDT
10_1101-2021_02_13_429885	74	41	was	be	VBD
10_1101-2021_02_13_429885	74	42	not	not	RB
10_1101-2021_02_13_429885	74	43	certified	certify	VBN
10_1101-2021_02_13_429885	74	44	by	by	IN
10_1101-2021_02_13_429885	74	45	peer	peer	NN
10_1101-2021_02_13_429885	74	46	review	review	NN
10_1101-2021_02_13_429885	74	47	)	)	-RRB-
10_1101-2021_02_13_429885	74	48	is	be	VBZ
10_1101-2021_02_13_429885	74	49	the	the	DT
10_1101-2021_02_13_429885	74	50	author	author	NN
10_1101-2021_02_13_429885	74	51	/	/	SYM
10_1101-2021_02_13_429885	74	52	funder	funder	NN
10_1101-2021_02_13_429885	74	53	,	,	,
10_1101-2021_02_13_429885	74	54	who	who	WP
10_1101-2021_02_13_429885	74	55	has	have	VBZ
10_1101-2021_02_13_429885	74	56	granted	grant	VBN
10_1101-2021_02_13_429885	74	57	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	74	58	a	a	DT
10_1101-2021_02_13_429885	74	59	license	license	NN
10_1101-2021_02_13_429885	74	60	to	to	TO
10_1101-2021_02_13_429885	74	61	display	display	VB
10_1101-2021_02_13_429885	74	62	the	the	DT
10_1101-2021_02_13_429885	74	63	preprint	preprint	NN
10_1101-2021_02_13_429885	74	64	in	in	IN
10_1101-2021_02_13_429885	74	65	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	74	66	.	.	.
10_1101-2021_02_13_429885	75	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	75	2	is	be	VBZ
10_1101-2021_02_13_429885	75	3	made	make	VBN
10_1101-2021_02_13_429885	75	4	The	the	DT
10_1101-2021_02_13_429885	75	5	copyright	copyright	NN
10_1101-2021_02_13_429885	75	6	holder	holder	NN
10_1101-2021_02_13_429885	75	7	for	for	IN
10_1101-2021_02_13_429885	75	8	this	this	DT
10_1101-2021_02_13_429885	75	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	75	10	version	version	NN
10_1101-2021_02_13_429885	75	11	posted	post	VBD
10_1101-2021_02_13_429885	75	12	February	February	NNP
10_1101-2021_02_13_429885	75	13	13	13	CD
10_1101-2021_02_13_429885	75	14	,	,	,
10_1101-2021_02_13_429885	75	15	2021	2021	CD
10_1101-2021_02_13_429885	75	16	.	.	.
10_1101-2021_02_13_429885	75	17	;	;	:
10_1101-2021_02_13_429885	75	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	75	19	:	:	:
10_1101-2021_02_13_429885	75	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	75	21	preprint	preprint	NN
10_1101-2021_02_13_429885	75	22	https://paperpile.com/c/rqVmzs/bHGV+chqB	https://paperpile.com/c/rqvmzs/bhgv+chqb	NN
10_1101-2021_02_13_429885	75	23	https://paperpile.com/c/rqVmzs/bHGV	https://paperpile.com/c/rqvmzs/bhgv	PRP
10_1101-2021_02_13_429885	75	24	https://paperpile.com/c/rqVmzs/IX1R+ydMa+rmmC+yAgN	https://paperpile.com/c/rqvmzs/ix1r+ydma+rmmc+yagn	JJ
10_1101-2021_02_13_429885	75	25	https://paperpile.com/c/rqVmzs/IX1R+ydMa+rmmC+yAgN	https://paperpile.com/c/rqvmzs/ix1r+ydma+rmmc+yagn	JJ
10_1101-2021_02_13_429885	75	26	https://paperpile.com/c/rqVmzs/CxXa+67up+mWfz	https://paperpile.com/c/rqVmzs/CxXa+67up+mWfz	NNP
10_1101-2021_02_13_429885	75	27	https://paperpile.com/c/rqVmzs/CxXa+67up+mWfz	https://paperpile.com/c/rqVmzs/CxXa+67up+mWfz	NNP
10_1101-2021_02_13_429885	75	28	https://paperpile.com/c/rqVmzs/Uxwc	https://paperpile.com/c/rqVmzs/Uxwc	NNP
10_1101-2021_02_13_429885	75	29	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	NNP
10_1101-2021_02_13_429885	75	30	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	75	31	Househam	Househam	NNP
10_1101-2021_02_13_429885	75	32	et	et	FW
10_1101-2021_02_13_429885	75	33	al	al	NNP
10_1101-2021_02_13_429885	75	34	.	.	.
10_1101-2021_02_13_429885	76	1	A	a	DT
10_1101-2021_02_13_429885	76	2	fully	fully	RB
10_1101-2021_02_13_429885	76	3	automated	automate	VBN
10_1101-2021_02_13_429885	76	4	approach	approach	NN
10_1101-2021_02_13_429885	76	5	for	for	IN
10_1101-2021_02_13_429885	76	6	quality	quality	NN
10_1101-2021_02_13_429885	76	7	control	control	NN
10_1101-2021_02_13_429885	76	8	of	of	IN
10_1101-2021_02_13_429885	76	9	cancer	cancer	NN
10_1101-2021_02_13_429885	76	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	76	11	in	in	IN
10_1101-2021_02_13_429885	76	12	the	the	DT
10_1101-2021_02_13_429885	76	13	era	era	NN
10_1101-2021_02_13_429885	76	14	of	of	IN
10_1101-2021_02_13_429885	76	15	high	high	JJ
10_1101-2021_02_13_429885	76	16	-	-	HYPH
10_1101-2021_02_13_429885	76	17	resolution	resolution	NN
10_1101-2021_02_13_429885	76	18	whole	whole	JJ
10_1101-2021_02_13_429885	76	19	genome	genome	JJ
10_1101-2021_02_13_429885	76	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	76	21	.	.	.
10_1101-2021_02_13_429885	77	1	feature	feature	NN
10_1101-2021_02_13_429885	77	2	for	for	IN
10_1101-2021_02_13_429885	77	3	large	large	JJ
10_1101-2021_02_13_429885	77	4	-	-	HYPH
10_1101-2021_02_13_429885	77	5	scale	scale	NN
10_1101-2021_02_13_429885	77	6	genomics	genomic	NNS
10_1101-2021_02_13_429885	77	7	consortia	consortium	NNS
10_1101-2021_02_13_429885	77	8	that	that	WDT
10_1101-2021_02_13_429885	77	9	analyse	analyse	VBP
10_1101-2021_02_13_429885	77	10	many	many	JJ
10_1101-2021_02_13_429885	77	11	samples	sample	NNS
10_1101-2021_02_13_429885	77	12	per	per	IN
10_1101-2021_02_13_429885	77	13	day	day	NN
10_1101-2021_02_13_429885	77	14	.	.	.
10_1101-2021_02_13_429885	78	1	To	to	TO
10_1101-2021_02_13_429885	78	2	demonstrate	demonstrate	VB
10_1101-2021_02_13_429885	78	3	the	the	DT
10_1101-2021_02_13_429885	78	4	tool	tool	NN
10_1101-2021_02_13_429885	78	5	we	-PRON-	PRP
10_1101-2021_02_13_429885	78	6	analysed	analyse	VBD
10_1101-2021_02_13_429885	78	7	11	11	CD
10_1101-2021_02_13_429885	78	8	bulk	bulk	NN
10_1101-2021_02_13_429885	78	9	WGS	WGS	NNP
10_1101-2021_02_13_429885	78	10	datasets	dataset	VBZ
10_1101-2021_02_13_429885	78	11	from	from	IN
10_1101-2021_02_13_429885	78	12	two	two	CD
10_1101-2021_02_13_429885	78	13	multi	multi	JJ
10_1101-2021_02_13_429885	78	14	-	-	JJ
10_1101-2021_02_13_429885	78	15	region	region	JJ
10_1101-2021_02_13_429885	78	16	colorectal	colorectal	JJ
10_1101-2021_02_13_429885	78	17	cancers	cancer	NNS
10_1101-2021_02_13_429885	78	18	,	,	,
10_1101-2021_02_13_429885	78	19	and	and	CC
10_1101-2021_02_13_429885	78	20	analysed	analyse	VBD
10_1101-2021_02_13_429885	78	21	high	high	JJ
10_1101-2021_02_13_429885	78	22	-	-	HYPH
10_1101-2021_02_13_429885	78	23	quality	quality	NN
10_1101-2021_02_13_429885	78	24	whole	whole	JJ
10_1101-2021_02_13_429885	78	25	-	-	HYPH
10_1101-2021_02_13_429885	78	26	genomes	genome	NNS
10_1101-2021_02_13_429885	78	27	from	from	IN
10_1101-2021_02_13_429885	78	28	the	the	DT
10_1101-2021_02_13_429885	78	29	Pan	Pan	NNP
10_1101-2021_02_13_429885	78	30	0651	0651	CD
10_1101-2021_02_13_429885	78	31	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	78	32	Analysis	Analysis	NNP
10_1101-2021_02_13_429885	78	33	of	of	IN
10_1101-2021_02_13_429885	78	34	Whole	Whole	NNP
10_1101-2021_02_13_429885	78	35	Genomes	Genomes	NNP
10_1101-2021_02_13_429885	78	36	(	(	-LRB-
10_1101-2021_02_13_429885	78	37	PCAWG	PCAWG	NNP
10_1101-2021_02_13_429885	78	38	)	)	-RRB-
10_1101-2021_02_13_429885	78	39	cohort	cohort	NN
10_1101-2021_02_13_429885	78	40	​(Campbell	​(Campbell	NNP
10_1101-2021_02_13_429885	78	41	et	et	FW
10_1101-2021_02_13_429885	78	42	al	al	NNP
10_1101-2021_02_13_429885	78	43	.	.	.
10_1101-2021_02_13_429885	79	1	2020)​.	2020)​.	CD
10_1101-2021_02_13_429885	80	1	Results	result	NNS
10_1101-2021_02_13_429885	80	2	The	the	DT
10_1101-2021_02_13_429885	80	3	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	80	4	framework	framework	NN
10_1101-2021_02_13_429885	80	5	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	80	6	can	can	MD
10_1101-2021_02_13_429885	80	7	perform	perform	VB
10_1101-2021_02_13_429885	80	8	different	different	JJ
10_1101-2021_02_13_429885	80	9	types	type	NNS
10_1101-2021_02_13_429885	80	10	of	of	IN
10_1101-2021_02_13_429885	80	11	operations	operation	NNS
10_1101-2021_02_13_429885	80	12	on	on	IN
10_1101-2021_02_13_429885	80	13	CNAs	cna	NNS
10_1101-2021_02_13_429885	80	14	and	and	CC
10_1101-2021_02_13_429885	80	15	somatic	somatic	JJ
10_1101-2021_02_13_429885	80	16	mutation	mutation	NN
10_1101-2021_02_13_429885	80	17	calls	call	NNS
10_1101-2021_02_13_429885	80	18	obtained	obtain	VBN
10_1101-2021_02_13_429885	80	19	from	from	IN
10_1101-2021_02_13_429885	80	20	bulk	bulk	NNP
10_1101-2021_02_13_429885	80	21	WGS	WGS	NNP
10_1101-2021_02_13_429885	80	22	.	.	.
10_1101-2021_02_13_429885	81	1	In	in	IN
10_1101-2021_02_13_429885	81	2	what	what	WP
10_1101-2021_02_13_429885	81	3	follows	follow	VBZ
10_1101-2021_02_13_429885	81	4	,	,	,
10_1101-2021_02_13_429885	81	5	we	-PRON-	PRP
10_1101-2021_02_13_429885	81	6	will	will	MD
10_1101-2021_02_13_429885	81	7	refer	refer	VB
10_1101-2021_02_13_429885	81	8	explicitly	explicitly	RB
10_1101-2021_02_13_429885	81	9	to	to	IN
10_1101-2021_02_13_429885	81	10	SNVs	SNVs	NNPS
10_1101-2021_02_13_429885	81	11	as	as	IN
10_1101-2021_02_13_429885	81	12	the	the	DT
10_1101-2021_02_13_429885	81	13	main	main	JJ
10_1101-2021_02_13_429885	81	14	type	type	NN
10_1101-2021_02_13_429885	81	15	of	of	IN
10_1101-2021_02_13_429885	81	16	mutation	mutation	NN
10_1101-2021_02_13_429885	81	17	used	use	VBN
10_1101-2021_02_13_429885	81	18	,	,	,
10_1101-2021_02_13_429885	81	19	but	but	CC
10_1101-2021_02_13_429885	81	20	in	in	IN
10_1101-2021_02_13_429885	81	21	principle	principle	JJ
10_1101-2021_02_13_429885	81	22	other	other	JJ
10_1101-2021_02_13_429885	81	23	types	type	NNS
10_1101-2021_02_13_429885	81	24	of	of	IN
10_1101-2021_02_13_429885	81	25	substitutions	substitution	NNS
10_1101-2021_02_13_429885	81	26	such	such	JJ
10_1101-2021_02_13_429885	81	27	as	as	IN
10_1101-2021_02_13_429885	81	28	insertions	insertion	NNS
10_1101-2021_02_13_429885	81	29	or	or	CC
10_1101-2021_02_13_429885	81	30	deletions	deletion	NNS
10_1101-2021_02_13_429885	81	31	also	also	RB
10_1101-2021_02_13_429885	81	32	apply	apply	VBP
10_1101-2021_02_13_429885	81	33	.	.	.
10_1101-2021_02_13_429885	82	1	The	the	DT
10_1101-2021_02_13_429885	82	2	package	package	NN
10_1101-2021_02_13_429885	82	3	supports	support	VBZ
10_1101-2021_02_13_429885	82	4	the	the	DT
10_1101-2021_02_13_429885	82	5	most	most	RBS
10_1101-2021_02_13_429885	82	6	common	common	JJ
10_1101-2021_02_13_429885	82	7	CNA	cna	NN
10_1101-2021_02_13_429885	82	8	copy	copy	NN
10_1101-2021_02_13_429885	82	9	types	type	NNS
10_1101-2021_02_13_429885	82	10	found	find	VBN
10_1101-2021_02_13_429885	82	11	in	in	IN
10_1101-2021_02_13_429885	82	12	cancers	cancer	NNS
10_1101-2021_02_13_429885	82	13	:	:	:
10_1101-2021_02_13_429885	82	14	heterozygous	heterozygous	JJ
10_1101-2021_02_13_429885	82	15	normal	normal	JJ
10_1101-2021_02_13_429885	82	16	states	state	NNS
10_1101-2021_02_13_429885	82	17	(	(	-LRB-
10_1101-2021_02_13_429885	82	18	1:1	1:1	CD
10_1101-2021_02_13_429885	82	19	chromosome	chromosome	NN
10_1101-2021_02_13_429885	82	20	complement	complement	NN
10_1101-2021_02_13_429885	82	21	)	)	-RRB-
10_1101-2021_02_13_429885	82	22	,	,	,
10_1101-2021_02_13_429885	82	23	loss	loss	NN
10_1101-2021_02_13_429885	82	24	of	of	IN
10_1101-2021_02_13_429885	82	25	heterozygosity	heterozygosity	NN
10_1101-2021_02_13_429885	82	26	(	(	-LRB-
10_1101-2021_02_13_429885	82	27	LOH	LOH	NNP
10_1101-2021_02_13_429885	82	28	)	)	-RRB-
10_1101-2021_02_13_429885	82	29	in	in	IN
10_1101-2021_02_13_429885	82	30	monosomy	monosomy	NNP
10_1101-2021_02_13_429885	82	31	(	(	-LRB-
10_1101-2021_02_13_429885	82	32	1:0	1:0	CD
10_1101-2021_02_13_429885	82	33	)	)	-RRB-
10_1101-2021_02_13_429885	82	34	and	and	CC
10_1101-2021_02_13_429885	82	35	copy	copy	NN
10_1101-2021_02_13_429885	82	36	-	-	HYPH
10_1101-2021_02_13_429885	82	37	neutral	neutral	JJ
10_1101-2021_02_13_429885	82	38	(	(	-LRB-
10_1101-2021_02_13_429885	82	39	2:0	2:0	CD
10_1101-2021_02_13_429885	82	40	)	)	-RRB-
10_1101-2021_02_13_429885	82	41	form	form	NN
10_1101-2021_02_13_429885	82	42	,	,	,
10_1101-2021_02_13_429885	82	43	trisomy	trisomy	JJ
10_1101-2021_02_13_429885	82	44	(	(	-LRB-
10_1101-2021_02_13_429885	82	45	2:1	2:1	CD
10_1101-2021_02_13_429885	82	46	)	)	-RRB-
10_1101-2021_02_13_429885	82	47	or	or	CC
10_1101-2021_02_13_429885	82	48	tetrasomy	tetrasomy	NN
10_1101-2021_02_13_429885	82	49	(	(	-LRB-
10_1101-2021_02_13_429885	82	50	2:2	2:2	CD
10_1101-2021_02_13_429885	82	51	)	)	-RRB-
10_1101-2021_02_13_429885	82	52	gains	gain	NNS
10_1101-2021_02_13_429885	82	53	.	.	.
10_1101-2021_02_13_429885	83	1	The	the	DT
10_1101-2021_02_13_429885	83	2	tool	tool	NN
10_1101-2021_02_13_429885	83	3	also	also	RB
10_1101-2021_02_13_429885	83	4	works	work	VBZ
10_1101-2021_02_13_429885	83	5	with	with	IN
10_1101-2021_02_13_429885	83	6	exome	exome	JJ
10_1101-2021_02_13_429885	83	7	data	datum	NNS
10_1101-2021_02_13_429885	83	8	,	,	,
10_1101-2021_02_13_429885	83	9	but	but	CC
10_1101-2021_02_13_429885	83	10	the	the	DT
10_1101-2021_02_13_429885	83	11	reduced	reduced	JJ
10_1101-2021_02_13_429885	83	12	mutational	mutational	JJ
10_1101-2021_02_13_429885	83	13	burden	burden	NN
10_1101-2021_02_13_429885	83	14	can	can	MD
10_1101-2021_02_13_429885	83	15	,	,	,
10_1101-2021_02_13_429885	83	16	in	in	IN
10_1101-2021_02_13_429885	83	17	general	general	JJ
10_1101-2021_02_13_429885	83	18	,	,	,
10_1101-2021_02_13_429885	83	19	lower	lower	VB
10_1101-2021_02_13_429885	83	20	the	the	DT
10_1101-2021_02_13_429885	83	21	reliability	reliability	NN
10_1101-2021_02_13_429885	83	22	of	of	IN
10_1101-2021_02_13_429885	83	23	the	the	DT
10_1101-2021_02_13_429885	83	24	QC	QC	NNP
10_1101-2021_02_13_429885	83	25	score	score	NN
10_1101-2021_02_13_429885	83	26	(	(	-LRB-
10_1101-2021_02_13_429885	83	27	​Supplementary	​supplementary	JJ
10_1101-2021_02_13_429885	83	28	Figure	Figure	NNP
10_1101-2021_02_13_429885	83	29	S1​	s1​	NN
10_1101-2021_02_13_429885	83	30	)	)	-RRB-
10_1101-2021_02_13_429885	83	31	.	.	.
10_1101-2021_02_13_429885	84	1	Many	many	JJ
10_1101-2021_02_13_429885	84	2	metrics	metric	NNS
10_1101-2021_02_13_429885	84	3	output	output	NN
10_1101-2021_02_13_429885	84	4	by	by	IN
10_1101-2021_02_13_429885	84	5	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	84	6	are	be	VBP
10_1101-2021_02_13_429885	84	7	derived	derive	VBN
10_1101-2021_02_13_429885	84	8	from	from	IN
10_1101-2021_02_13_429885	84	9	the	the	DT
10_1101-2021_02_13_429885	84	10	link	link	NN
10_1101-2021_02_13_429885	84	11	between	between	IN
10_1101-2021_02_13_429885	84	12	copy	copy	NN
10_1101-2021_02_13_429885	84	13	-	-	HYPH
10_1101-2021_02_13_429885	84	14	state	state	NN
10_1101-2021_02_13_429885	84	15	profiles	profile	NNS
10_1101-2021_02_13_429885	84	16	(	(	-LRB-
10_1101-2021_02_13_429885	84	17	i.e.	i.e.	FW
10_1101-2021_02_13_429885	84	18	,	,	,
10_1101-2021_02_13_429885	84	19	the	the	DT
10_1101-2021_02_13_429885	84	20	copies	copy	NNS
10_1101-2021_02_13_429885	84	21	of	of	IN
10_1101-2021_02_13_429885	84	22	the	the	DT
10_1101-2021_02_13_429885	84	23	major	major	JJ
10_1101-2021_02_13_429885	84	24	and	and	CC
10_1101-2021_02_13_429885	84	25	minor	minor	JJ
10_1101-2021_02_13_429885	84	26	alleles	allele	NNS
10_1101-2021_02_13_429885	84	27	,	,	,
10_1101-2021_02_13_429885	84	28	which	which	WDT
10_1101-2021_02_13_429885	84	29	sum	sum	VBP
10_1101-2021_02_13_429885	84	30	up	up	RP
10_1101-2021_02_13_429885	84	31	to	to	IN
10_1101-2021_02_13_429885	84	32	the	the	DT
10_1101-2021_02_13_429885	84	33	ploidy	ploidy	NN
10_1101-2021_02_13_429885	84	34	of	of	IN
10_1101-2021_02_13_429885	84	35	a	a	DT
10_1101-2021_02_13_429885	84	36	segment	segment	NN
10_1101-2021_02_13_429885	84	37	)	)	-RRB-
10_1101-2021_02_13_429885	84	38	and	and	CC
10_1101-2021_02_13_429885	84	39	allele	allele	NNP
10_1101-2021_02_13_429885	84	40	frequencies	frequency	NNS
10_1101-2021_02_13_429885	84	41	that	that	WDT
10_1101-2021_02_13_429885	84	42	are	be	VBP
10_1101-2021_02_13_429885	84	43	explicit	explicit	JJ
10_1101-2021_02_13_429885	84	44	from	from	IN
10_1101-2021_02_13_429885	84	45	read	read	VBN
10_1101-2021_02_13_429885	84	46	counts	count	NNS
10_1101-2021_02_13_429885	84	47	.	.	.
10_1101-2021_02_13_429885	85	1	Combinatorial	combinatorial	JJ
10_1101-2021_02_13_429885	85	2	equations	equation	NNS
10_1101-2021_02_13_429885	85	3	and	and	CC
10_1101-2021_02_13_429885	85	4	frequency	frequency	NN
10_1101-2021_02_13_429885	85	5	spectrum	spectrum	NN
10_1101-2021_02_13_429885	85	6	analysis	analysis	NN
10_1101-2021_02_13_429885	85	7	can	can	MD
10_1101-2021_02_13_429885	85	8	quantitatively	quantitatively	RB
10_1101-2021_02_13_429885	85	9	determine	determine	VB
10_1101-2021_02_13_429885	85	10	if	if	IN
10_1101-2021_02_13_429885	85	11	CNAs	cna	NNS
10_1101-2021_02_13_429885	85	12	and	and	CC
10_1101-2021_02_13_429885	85	13	purity	purity	NN
10_1101-2021_02_13_429885	85	14	are	be	VBP
10_1101-2021_02_13_429885	85	15	consistent	consistent	JJ
10_1101-2021_02_13_429885	85	16	with	with	IN
10_1101-2021_02_13_429885	85	17	the	the	DT
10_1101-2021_02_13_429885	85	18	VAF	VAF	NNP
10_1101-2021_02_13_429885	85	19	distribution	distribution	NN
10_1101-2021_02_13_429885	85	20	(	(	-LRB-
10_1101-2021_02_13_429885	85	21	​Online	​online	JJ
10_1101-2021_02_13_429885	85	22	methods	method	NNS
10_1101-2021_02_13_429885	85	23	​	​	JJ
10_1101-2021_02_13_429885	85	24	)	)	-RRB-
10_1101-2021_02_13_429885	85	25	.	.	.
10_1101-2021_02_13_429885	86	1	This	this	DT
10_1101-2021_02_13_429885	86	2	score	score	NN
10_1101-2021_02_13_429885	86	3	also	also	RB
10_1101-2021_02_13_429885	86	4	suggests	suggest	VBZ
10_1101-2021_02_13_429885	86	5	“	"	``
10_1101-2021_02_13_429885	86	6	corrections	correction	NNS
10_1101-2021_02_13_429885	86	7	”	"	''
10_1101-2021_02_13_429885	86	8	to	to	TO
10_1101-2021_02_13_429885	86	9	automatically	automatically	RB
10_1101-2021_02_13_429885	86	10	fine	fine	JJ
10_1101-2021_02_13_429885	86	11	-	-	HYPH
10_1101-2021_02_13_429885	86	12	tune	tune	NN
10_1101-2021_02_13_429885	86	13	and	and	CC
10_1101-2021_02_13_429885	86	14	repeat	repeat	VB
10_1101-2021_02_13_429885	86	15	CNA	CNA	NNP
10_1101-2021_02_13_429885	86	16	calling	calling	NN
10_1101-2021_02_13_429885	86	17	runs	run	NNS
10_1101-2021_02_13_429885	86	18	.	.	.
10_1101-2021_02_13_429885	87	1	This	this	DT
10_1101-2021_02_13_429885	87	2	works	work	VBZ
10_1101-2021_02_13_429885	87	3	for	for	IN
10_1101-2021_02_13_429885	87	4	tools	tool	NNS
10_1101-2021_02_13_429885	87	5	that	that	WDT
10_1101-2021_02_13_429885	87	6	use	use	VBP
10_1101-2021_02_13_429885	87	7	either	either	DT
10_1101-2021_02_13_429885	87	8	Bayesian	bayesian	JJ
10_1101-2021_02_13_429885	87	9	priors	prior	NNS
10_1101-2021_02_13_429885	87	10	or	or	CC
10_1101-2021_02_13_429885	87	11	point	point	NN
10_1101-2021_02_13_429885	87	12	estimates	estimate	NNS
10_1101-2021_02_13_429885	87	13	of	of	IN
10_1101-2021_02_13_429885	87	14	the	the	DT
10_1101-2021_02_13_429885	87	15	parameters	parameter	NNS
10_1101-2021_02_13_429885	87	16	.	.	.
10_1101-2021_02_13_429885	88	1	The	the	DT
10_1101-2021_02_13_429885	88	2	key	key	JJ
10_1101-2021_02_13_429885	88	3	equations	equation	NNS
10_1101-2021_02_13_429885	88	4	for	for	IN
10_1101-2021_02_13_429885	88	5	a	a	DT
10_1101-2021_02_13_429885	88	6	somatic	somatic	JJ
10_1101-2021_02_13_429885	88	7	mutation	mutation	NN
10_1101-2021_02_13_429885	88	8	link	link	VB
10_1101-2021_02_13_429885	88	9	its	-PRON-	PRP$
10_1101-2021_02_13_429885	88	10	VAF	VAF	NNP
10_1101-2021_02_13_429885	88	11	and	and	CC
10_1101-2021_02_13_429885	88	12	CCF	CCF	NNP
10_1101-2021_02_13_429885	88	13	,	,	,
10_1101-2021_02_13_429885	88	14	to	to	TO
10_1101-2021_02_13_429885	88	15	sample	sample	VB
10_1101-2021_02_13_429885	88	16	purity	purity	NN
10_1101-2021_02_13_429885	88	17	,	,	,
10_1101-2021_02_13_429885	88	18	tumour	tumour	NN
10_1101-2021_02_13_429885	88	19	ploidy	ploidy	NN
10_1101-2021_02_13_429885	88	20	,	,	,
10_1101-2021_02_13_429885	88	21	and	and	CC
10_1101-2021_02_13_429885	88	22	​	​	JJ
10_1101-2021_02_13_429885	88	23	,	,	,
10_1101-2021_02_13_429885	88	24	the	the	DT
10_1101-2021_02_13_429885	88	25	number	number	NN
10_1101-2021_02_13_429885	88	26	of	of	IN
10_1101-2021_02_13_429885	88	27	copies	copy	NNS
10_1101-2021_02_13_429885	88	28	of	of	IN
10_1101-2021_02_13_429885	88	29	a	a	DT
10_1101-2021_02_13_429885	88	30	mutation	mutation	NN
10_1101-2021_02_13_429885	88	31	(	(	-LRB-
10_1101-2021_02_13_429885	88	32	​Figure	​figure	NN
10_1101-2021_02_13_429885	88	33	1a	1a	CD
10_1101-2021_02_13_429885	88	34	​	​	JJ
10_1101-2021_02_13_429885	88	35	)	)	-RRB-
10_1101-2021_02_13_429885	88	36	.	.	.
10_1101-2021_02_13_429885	89	1	Effectively	effectively	RB
10_1101-2021_02_13_429885	89	2	,	,	,
10_1101-2021_02_13_429885	89	3	for	for	IN
10_1101-2021_02_13_429885	89	4	complex	complex	JJ
10_1101-2021_02_13_429885	89	5	2:0	2:0	CD
10_1101-2021_02_13_429885	89	6	,	,	,
10_1101-2021_02_13_429885	89	7	2:1	2:1	CD
10_1101-2021_02_13_429885	89	8	and	and	CC
10_1101-2021_02_13_429885	89	9	2:2	2:2	CD
10_1101-2021_02_13_429885	89	10	copy	copy	NN
10_1101-2021_02_13_429885	89	11	states	state	NNS
10_1101-2021_02_13_429885	89	12	,	,	,
10_1101-2021_02_13_429885	89	13	phases	phase	VBZ
10_1101-2021_02_13_429885	89	14	mutations	mutation	NNS
10_1101-2021_02_13_429885	89	15	that	that	WDT
10_1101-2021_02_13_429885	89	16	were	be	VBD
10_1101-2021_02_13_429885	89	17	acquired	acquire	VBN
10_1101-2021_02_13_429885	89	18	before	before	IN
10_1101-2021_02_13_429885	89	19	or	or	CC
10_1101-2021_02_13_429885	89	20	after	after	IN
10_1101-2021_02_13_429885	89	21	the	the	DT
10_1101-2021_02_13_429885	89	22	copy	copy	NN
10_1101-2021_02_13_429885	89	23	number	number	NN
10_1101-2021_02_13_429885	89	24	event	event	NN
10_1101-2021_02_13_429885	89	25	(	(	-LRB-
10_1101-2021_02_13_429885	89	26	​Figure	​figure	NN
10_1101-2021_02_13_429885	89	27	1b	1b	NN
10_1101-2021_02_13_429885	89	28	​	​	JJ
10_1101-2021_02_13_429885	89	29	)	)	-RRB-
10_1101-2021_02_13_429885	89	30	.	.	.
10_1101-2021_02_13_429885	90	1	We	-PRON-	PRP
10_1101-2021_02_13_429885	90	2	remark	remark	VBP
10_1101-2021_02_13_429885	90	3	that	that	IN
10_1101-2021_02_13_429885	90	4	we	-PRON-	PRP
10_1101-2021_02_13_429885	90	5	observe	observe	VBP
10_1101-2021_02_13_429885	90	6	,	,	,
10_1101-2021_02_13_429885	90	7	and	and	CC
10_1101-2021_02_13_429885	90	8	infer	infer	JJ
10_1101-2021_02_13_429885	90	9	,	,	,
10_1101-2021_02_13_429885	90	10	​	​	JJ
10_1101-2021_02_13_429885	90	11	and	and	CC
10_1101-2021_02_13_429885	90	12	,	,	,
10_1101-2021_02_13_429885	90	13	finally	finally	RB
10_1101-2021_02_13_429885	90	14	deriving	derive	VBG
10_1101-2021_02_13_429885	90	15	,	,	,
10_1101-2021_02_13_429885	90	16	which	which	WDT
10_1101-2021_02_13_429885	90	17	is	be	VBZ
10_1101-2021_02_13_429885	90	18	difficult	difficult	JJ
10_1101-2021_02_13_429885	90	19	to	to	TO
10_1101-2021_02_13_429885	90	20	estimate	estimate	VB
10_1101-2021_02_13_429885	90	21	(	(	-LRB-
10_1101-2021_02_13_429885	90	22	​Figure	​figure	NN
10_1101-2021_02_13_429885	90	23	1c	1c	CD
10_1101-2021_02_13_429885	90	24	​	​	NN
10_1101-2021_02_13_429885	90	25	)	)	-RRB-
10_1101-2021_02_13_429885	90	26	.	.	.
10_1101-2021_02_13_429885	91	1	In	in	IN
10_1101-2021_02_13_429885	91	2	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	91	3	we	-PRON-	PRP
10_1101-2021_02_13_429885	91	4	use	use	VBP
10_1101-2021_02_13_429885	91	5	the	the	DT
10_1101-2021_02_13_429885	91	6	following	follow	VBG
10_1101-2021_02_13_429885	91	7	formula	formula	NN
10_1101-2021_02_13_429885	91	8	for	for	IN
10_1101-2021_02_13_429885	91	9	VAF	VAF	NNP
10_1101-2021_02_13_429885	91	10	(	(	-LRB-
10_1101-2021_02_13_429885	91	11	​Figure	​figure	NN
10_1101-2021_02_13_429885	91	12	1d​	1d​	CD
10_1101-2021_02_13_429885	91	13	)	)	-RRB-
10_1101-2021_02_13_429885	91	14	and	and	CC
10_1101-2021_02_13_429885	91	15	CCF	CCF	NNP
10_1101-2021_02_13_429885	91	16	.CC	.CC	NFP
10_1101-2021_02_13_429885	91	17	-	-	:
10_1101-2021_02_13_429885	91	18	BY	by	IN
10_1101-2021_02_13_429885	91	19	-	-	HYPH
10_1101-2021_02_13_429885	91	20	NC	NC	NNP
10_1101-2021_02_13_429885	91	21	-	-	HYPH
10_1101-2021_02_13_429885	91	22	ND	ND	NNP
10_1101-2021_02_13_429885	91	23	4.0	4.0	CD
10_1101-2021_02_13_429885	91	24	International	International	NNP
10_1101-2021_02_13_429885	91	25	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	91	26	under	under	IN
10_1101-2021_02_13_429885	91	27	a	a	DT
10_1101-2021_02_13_429885	91	28	(	(	-LRB-
10_1101-2021_02_13_429885	91	29	which	which	WDT
10_1101-2021_02_13_429885	91	30	was	be	VBD
10_1101-2021_02_13_429885	91	31	not	not	RB
10_1101-2021_02_13_429885	91	32	certified	certify	VBN
10_1101-2021_02_13_429885	91	33	by	by	IN
10_1101-2021_02_13_429885	91	34	peer	peer	NN
10_1101-2021_02_13_429885	91	35	review	review	NN
10_1101-2021_02_13_429885	91	36	)	)	-RRB-
10_1101-2021_02_13_429885	91	37	is	be	VBZ
10_1101-2021_02_13_429885	91	38	the	the	DT
10_1101-2021_02_13_429885	91	39	author	author	NN
10_1101-2021_02_13_429885	91	40	/	/	SYM
10_1101-2021_02_13_429885	91	41	funder	funder	NN
10_1101-2021_02_13_429885	91	42	,	,	,
10_1101-2021_02_13_429885	91	43	who	who	WP
10_1101-2021_02_13_429885	91	44	has	have	VBZ
10_1101-2021_02_13_429885	91	45	granted	grant	VBN
10_1101-2021_02_13_429885	91	46	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	91	47	a	a	DT
10_1101-2021_02_13_429885	91	48	license	license	NN
10_1101-2021_02_13_429885	91	49	to	to	TO
10_1101-2021_02_13_429885	91	50	display	display	VB
10_1101-2021_02_13_429885	91	51	the	the	DT
10_1101-2021_02_13_429885	91	52	preprint	preprint	NN
10_1101-2021_02_13_429885	91	53	in	in	IN
10_1101-2021_02_13_429885	91	54	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	91	55	.	.	.
10_1101-2021_02_13_429885	92	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	92	2	is	be	VBZ
10_1101-2021_02_13_429885	92	3	made	make	VBN
10_1101-2021_02_13_429885	92	4	The	the	DT
10_1101-2021_02_13_429885	92	5	copyright	copyright	NN
10_1101-2021_02_13_429885	92	6	holder	holder	NN
10_1101-2021_02_13_429885	92	7	for	for	IN
10_1101-2021_02_13_429885	92	8	this	this	DT
10_1101-2021_02_13_429885	92	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	92	10	version	version	NN
10_1101-2021_02_13_429885	92	11	posted	post	VBD
10_1101-2021_02_13_429885	92	12	February	February	NNP
10_1101-2021_02_13_429885	92	13	13	13	CD
10_1101-2021_02_13_429885	92	14	,	,	,
10_1101-2021_02_13_429885	92	15	2021	2021	CD
10_1101-2021_02_13_429885	92	16	.	.	.
10_1101-2021_02_13_429885	92	17	;	;	:
10_1101-2021_02_13_429885	92	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	92	19	:	:	:
10_1101-2021_02_13_429885	92	20	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	92	21	preprint	preprint	NN
10_1101-2021_02_13_429885	92	22	https://paperpile.com/c/rqVmzs/CxXa	https://paperpile.com/c/rqVmzs/CxXa	NNP
10_1101-2021_02_13_429885	92	23	https://www.codecogs.com/eqnedit.php?latex=v#0	https://www.codecogs.com/eqnedit.php?latex=v#0	NNP
10_1101-2021_02_13_429885	92	24	https://www.codecogs.com/eqnedit.php?latex=c#0	https://www.codecogs.com/eqnedit.php?latex=c#0	NNP
10_1101-2021_02_13_429885	92	25	https://www.codecogs.com/eqnedit.php?latex=%5Cpi#0	https://www.codecogs.com/eqnedit.php?latex=%5cpi#0	NN
10_1101-2021_02_13_429885	92	26	https://www.codecogs.com/eqnedit.php?latex=p#0	https://www.codecogs.com/eqnedit.php?latex=p#0	NNP
10_1101-2021_02_13_429885	92	27	https://www.codecogs.com/eqnedit.php?latex=m%5Cin%5C%7B1%2C2%5C%7D#0	https://www.codecogs.com/eqnedit.php?latex=m%5Cin%5C%7B1%2C2%5C%7D#0	NNP
10_1101-2021_02_13_429885	92	28	https://www.codecogs.com/eqnedit.php?latex=m#0	https://www.codecogs.com/eqnedit.php?latex=m#0	NNP
10_1101-2021_02_13_429885	92	29	https://www.codecogs.com/eqnedit.php?latex=v#0	https://www.codecogs.com/eqnedit.php?latex=v#0	NNP
10_1101-2021_02_13_429885	92	30	https://www.codecogs.com/eqnedit.php?latex=%5Cpi#0	https://www.codecogs.com/eqnedit.php?latex=%5cpi#0	NN
10_1101-2021_02_13_429885	92	31	https://www.codecogs.com/eqnedit.php?latex=p#0	https://www.codecogs.com/eqnedit.php?latex=p#0	NNP
10_1101-2021_02_13_429885	92	32	https://www.codecogs.com/eqnedit.php?latex=m#0	https://www.codecogs.com/eqnedit.php?latex=m#0	NN
10_1101-2021_02_13_429885	92	33	https://www.codecogs.com/eqnedit.php?latex=c#0	https://www.codecogs.com/eqnedit.php?latex=c#0	NNS
10_1101-2021_02_13_429885	92	34	https://www.codecogs.com/eqnedit.php?latex=v%20%3D%20%5Cdfrac%7B%5Cpi%7D%7B2(1-%5Cpi)%20%2B%20%5Cpi%20p%7D#0	https://www.codecogs.com/eqnedit.php?latex=v%20%3D%20%5Cdfrac%7B%5Cpi%7D%7B2(1-%5Cpi)%20%2B%20%5Cpi%20p%7D#0	NNS
10_1101-2021_02_13_429885	92	35	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	92	36	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	92	37	Househam	Househam	NNP
10_1101-2021_02_13_429885	92	38	et	et	FW
10_1101-2021_02_13_429885	92	39	al	al	NNP
10_1101-2021_02_13_429885	92	40	.	.	.
10_1101-2021_02_13_429885	93	1	A	a	DT
10_1101-2021_02_13_429885	93	2	fully	fully	RB
10_1101-2021_02_13_429885	93	3	automated	automate	VBN
10_1101-2021_02_13_429885	93	4	approach	approach	NN
10_1101-2021_02_13_429885	93	5	for	for	IN
10_1101-2021_02_13_429885	93	6	quality	quality	NN
10_1101-2021_02_13_429885	93	7	control	control	NN
10_1101-2021_02_13_429885	93	8	of	of	IN
10_1101-2021_02_13_429885	93	9	cancer	cancer	NN
10_1101-2021_02_13_429885	93	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	93	11	in	in	IN
10_1101-2021_02_13_429885	93	12	the	the	DT
10_1101-2021_02_13_429885	93	13	era	era	NN
10_1101-2021_02_13_429885	93	14	of	of	IN
10_1101-2021_02_13_429885	93	15	high	high	JJ
10_1101-2021_02_13_429885	93	16	-	-	HYPH
10_1101-2021_02_13_429885	93	17	resolution	resolution	NN
10_1101-2021_02_13_429885	93	18	whole	whole	JJ
10_1101-2021_02_13_429885	93	19	genome	genome	JJ
10_1101-2021_02_13_429885	93	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	93	21	.	.	.
10_1101-2021_02_13_429885	94	1	These	these	DT
10_1101-2021_02_13_429885	94	2	formulas	formula	NNS
10_1101-2021_02_13_429885	94	3	lead	lead	VBP
10_1101-2021_02_13_429885	94	4	to	to	IN
10_1101-2021_02_13_429885	94	5	other	other	JJ
10_1101-2021_02_13_429885	94	6	interesting	interesting	JJ
10_1101-2021_02_13_429885	94	7	quantities	quantity	NNS
10_1101-2021_02_13_429885	94	8	(	(	-LRB-
10_1101-2021_02_13_429885	94	9	​Online	​online	JJ
10_1101-2021_02_13_429885	94	10	methods	method	NNS
10_1101-2021_02_13_429885	94	11	​	​	JJ
10_1101-2021_02_13_429885	94	12	)	)	-RRB-
10_1101-2021_02_13_429885	94	13	.	.	.
10_1101-2021_02_13_429885	95	1	For	for	IN
10_1101-2021_02_13_429885	95	2	instance	instance	NN
10_1101-2021_02_13_429885	95	3	,	,	,
10_1101-2021_02_13_429885	95	4	if	if	IN
10_1101-2021_02_13_429885	95	5	we	-PRON-	PRP
10_1101-2021_02_13_429885	95	6	know	know	VBP
10_1101-2021_02_13_429885	95	7	tumour	tumour	NN
10_1101-2021_02_13_429885	95	8	purity	purity	NN
10_1101-2021_02_13_429885	95	9	and	and	CC
10_1101-2021_02_13_429885	95	10	the	the	DT
10_1101-2021_02_13_429885	95	11	ploidy	ploidy	NN
10_1101-2021_02_13_429885	95	12	of	of	IN
10_1101-2021_02_13_429885	95	13	a	a	DT
10_1101-2021_02_13_429885	95	14	CNA	CNA	NNP
10_1101-2021_02_13_429885	95	15	segment	segment	NN
10_1101-2021_02_13_429885	95	16	,	,	,
10_1101-2021_02_13_429885	95	17	then	then	RB
10_1101-2021_02_13_429885	95	18	the	the	DT
10_1101-2021_02_13_429885	95	19	VAF	VAF	NNP
10_1101-2021_02_13_429885	95	20	mutations	mutation	NNS
10_1101-2021_02_13_429885	95	21	mapped	map	VBN
10_1101-2021_02_13_429885	95	22	to	to	IN
10_1101-2021_02_13_429885	95	23	the	the	DT
10_1101-2021_02_13_429885	95	24	segment	segment	NN
10_1101-2021_02_13_429885	95	25	must	must	MD
10_1101-2021_02_13_429885	95	26	peak	peak	VB
10_1101-2021_02_13_429885	95	27	at	at	IN
10_1101-2021_02_13_429885	95	28	a	a	DT
10_1101-2021_02_13_429885	95	29	known	know	VBN
10_1101-2021_02_13_429885	95	30	location	location	NN
10_1101-2021_02_13_429885	95	31	.	.	.
10_1101-2021_02_13_429885	96	1	The	the	DT
10_1101-2021_02_13_429885	96	2	value	value	NN
10_1101-2021_02_13_429885	96	3	for	for	IN
10_1101-2021_02_13_429885	96	4	follows	follow	VBZ
10_1101-2021_02_13_429885	96	5	from	from	IN
10_1101-2021_02_13_429885	96	6	x	x	NN
10_1101-2021_02_13_429885	96	7	x	x	NN
10_1101-2021_02_13_429885	96	8	combinatorial	combinatorial	JJ
10_1101-2021_02_13_429885	96	9	arguments	argument	NNS
10_1101-2021_02_13_429885	96	10	relating	relate	VBG
10_1101-2021_02_13_429885	96	11	all	all	DT
10_1101-2021_02_13_429885	96	12	other	other	JJ
10_1101-2021_02_13_429885	96	13	variables	variable	NNS
10_1101-2021_02_13_429885	96	14	​(Nik	​(nik	CD
10_1101-2021_02_13_429885	96	15	-	-	HYPH
10_1101-2021_02_13_429885	96	16	Zainal	Zainal	NNP
10_1101-2021_02_13_429885	96	17	et	et	NNP
10_1101-2021_02_13_429885	96	18	al	al	NNP
10_1101-2021_02_13_429885	96	19	.	.	NNP
10_1101-2021_02_13_429885	96	20	,	,	,
10_1101-2021_02_13_429885	96	21	2012)​.	2012)​.	CD
10_1101-2021_02_13_429885	97	1	From	from	IN
10_1101-2021_02_13_429885	97	2	a	a	DT
10_1101-2021_02_13_429885	97	3	QC	QC	NNP
10_1101-2021_02_13_429885	97	4	perspective	perspective	NN
10_1101-2021_02_13_429885	97	5	,	,	,
10_1101-2021_02_13_429885	97	6	the	the	DT
10_1101-2021_02_13_429885	97	7	euclidean	euclidean	JJ
10_1101-2021_02_13_429885	97	8	distance	distance	NN
10_1101-2021_02_13_429885	97	9	between	between	IN
10_1101-2021_02_13_429885	97	10	the	the	DT
10_1101-2021_02_13_429885	97	11	theoretical	theoretical	JJ
10_1101-2021_02_13_429885	97	12	expectation	expectation	NN
10_1101-2021_02_13_429885	97	13	and	and	CC
10_1101-2021_02_13_429885	97	14	the	the	DT
10_1101-2021_02_13_429885	97	15	x	x	NN
10_1101-2021_02_13_429885	97	16	peaks	peak	NNS
10_1101-2021_02_13_429885	97	17	observed	observe	VBN
10_1101-2021_02_13_429885	97	18	from	from	IN
10_1101-2021_02_13_429885	97	19	data	datum	NNS
10_1101-2021_02_13_429885	97	20	is	be	VBZ
10_1101-2021_02_13_429885	97	21	an	an	DT
10_1101-2021_02_13_429885	97	22	error	error	NN
10_1101-2021_02_13_429885	97	23	score	score	NN
10_1101-2021_02_13_429885	97	24	that	that	WDT
10_1101-2021_02_13_429885	97	25	approaches	approach	VBZ
10_1101-2021_02_13_429885	97	26	0	0	CD
10_1101-2021_02_13_429885	97	27	for	for	IN
10_1101-2021_02_13_429885	97	28	perfect	perfect	JJ
10_1101-2021_02_13_429885	97	29	calls	call	NNS
10_1101-2021_02_13_429885	97	30	,	,	,
10_1101-2021_02_13_429885	97	31	and	and	CC
10_1101-2021_02_13_429885	97	32	grows	grow	VBZ
10_1101-2021_02_13_429885	97	33	otherwise	otherwise	RB
10_1101-2021_02_13_429885	97	34	.	.	.
10_1101-2021_02_13_429885	98	1	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	98	2	can	can	MD
10_1101-2021_02_13_429885	98	3	visualise	visualise	VB
10_1101-2021_02_13_429885	98	4	the	the	DT
10_1101-2021_02_13_429885	98	5	input	input	NN
10_1101-2021_02_13_429885	98	6	segments	segment	NNS
10_1101-2021_02_13_429885	98	7	(	(	-LRB-
10_1101-2021_02_13_429885	98	8	​Figure	​figure	NN
10_1101-2021_02_13_429885	98	9	2a	2a	CD
10_1101-2021_02_13_429885	98	10	​	​	JJ
10_1101-2021_02_13_429885	98	11	)	)	-RRB-
10_1101-2021_02_13_429885	98	12	and	and	CC
10_1101-2021_02_13_429885	98	13	read	read	VBD
10_1101-2021_02_13_429885	98	14	counts	count	NNS
10_1101-2021_02_13_429885	98	15	(	(	-LRB-
10_1101-2021_02_13_429885	98	16	​Figure	​figure	NN
10_1101-2021_02_13_429885	98	17	2b	2b	NNS
10_1101-2021_02_13_429885	98	18	-	-	HYPH
10_1101-2021_02_13_429885	98	19	d	d	NN
10_1101-2021_02_13_429885	98	20	​	​	NNP
10_1101-2021_02_13_429885	98	21	)	)	-RRB-
10_1101-2021_02_13_429885	98	22	.	.	.
10_1101-2021_02_13_429885	99	1	Other	other	JJ
10_1101-2021_02_13_429885	99	2	analysis	analysis	NN
10_1101-2021_02_13_429885	99	3	such	such	JJ
10_1101-2021_02_13_429885	99	4	as	as	IN
10_1101-2021_02_13_429885	99	5	CCFs	ccf	NNS
10_1101-2021_02_13_429885	99	6	computation	computation	NN
10_1101-2021_02_13_429885	99	7	and	and	CC
10_1101-2021_02_13_429885	99	8	genome	genome	JJ
10_1101-2021_02_13_429885	99	9	fragmentation	fragmentation	NN
10_1101-2021_02_13_429885	99	10	analysis	analysis	NN
10_1101-2021_02_13_429885	99	11	are	be	VBP
10_1101-2021_02_13_429885	99	12	also	also	RB
10_1101-2021_02_13_429885	99	13	available	available	JJ
10_1101-2021_02_13_429885	99	14	,	,	,
10_1101-2021_02_13_429885	99	15	and	and	CC
10_1101-2021_02_13_429885	99	16	have	have	VBP
10_1101-2021_02_13_429885	99	17	other	other	JJ
10_1101-2021_02_13_429885	99	18	visualisations	visualisation	NNS
10_1101-2021_02_13_429885	99	19	(	(	-LRB-
10_1101-2021_02_13_429885	99	20	​Figure	​figure	NN
10_1101-2021_02_13_429885	99	21	2e​	2e​	CD
10_1101-2021_02_13_429885	99	22	)	)	-RRB-
10_1101-2021_02_13_429885	99	23	.	.	.
10_1101-2021_02_13_429885	100	1	The	the	DT
10_1101-2021_02_13_429885	100	2	scores	score	NNS
10_1101-2021_02_13_429885	100	3	of	of	IN
10_1101-2021_02_13_429885	100	4	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	100	5	can	can	MD
10_1101-2021_02_13_429885	100	6	be	be	VB
10_1101-2021_02_13_429885	100	7	used	use	VBN
10_1101-2021_02_13_429885	100	8	to	to	TO
10_1101-2021_02_13_429885	100	9	determine	determine	VB
10_1101-2021_02_13_429885	100	10	a	a	DT
10_1101-2021_02_13_429885	100	11	QC	QC	NNP
10_1101-2021_02_13_429885	100	12	PASS	pas	NNS
10_1101-2021_02_13_429885	100	13	or	or	CC
10_1101-2021_02_13_429885	100	14	FAIL	FAIL	NNP
10_1101-2021_02_13_429885	100	15	status	status	NN
10_1101-2021_02_13_429885	100	16	for	for	IN
10_1101-2021_02_13_429885	100	17	every	every	DT
10_1101-2021_02_13_429885	100	18	copy	copy	NN
10_1101-2021_02_13_429885	100	19	state	state	NN
10_1101-2021_02_13_429885	100	20	within	within	IN
10_1101-2021_02_13_429885	100	21	a	a	DT
10_1101-2021_02_13_429885	100	22	tumour	tumour	NN
10_1101-2021_02_13_429885	100	23	genome	genome	NN
10_1101-2021_02_13_429885	100	24	,	,	,
10_1101-2021_02_13_429885	100	25	weighting	weight	VBG
10_1101-2021_02_13_429885	100	26	different	different	JJ
10_1101-2021_02_13_429885	100	27	evidence	evidence	NN
10_1101-2021_02_13_429885	100	28	from	from	IN
10_1101-2021_02_13_429885	100	29	the	the	DT
10_1101-2021_02_13_429885	100	30	data	datum	NNS
10_1101-2021_02_13_429885	100	31	.	.	.
10_1101-2021_02_13_429885	101	1	One	one	CD
10_1101-2021_02_13_429885	101	2	score	score	NN
10_1101-2021_02_13_429885	101	3	is	be	VBZ
10_1101-2021_02_13_429885	101	4	for	for	IN
10_1101-2021_02_13_429885	101	5	the	the	DT
10_1101-2021_02_13_429885	101	6	quality	quality	NN
10_1101-2021_02_13_429885	101	7	of	of	IN
10_1101-2021_02_13_429885	101	8	CNA	CNA	NNP
10_1101-2021_02_13_429885	101	9	segmentation	segmentation	NN
10_1101-2021_02_13_429885	101	10	and	and	CC
10_1101-2021_02_13_429885	101	11	tumour	tumour	NN
10_1101-2021_02_13_429885	101	12	purity	purity	NN
10_1101-2021_02_13_429885	101	13	,	,	,
10_1101-2021_02_13_429885	101	14	and	and	CC
10_1101-2021_02_13_429885	101	15	one	one	CD
10_1101-2021_02_13_429885	101	16	for	for	IN
10_1101-2021_02_13_429885	101	17	CCF	ccf	NN
10_1101-2021_02_13_429885	101	18	values	value	NNS
10_1101-2021_02_13_429885	101	19	.	.	.
10_1101-2021_02_13_429885	102	1	The	the	DT
10_1101-2021_02_13_429885	102	2	former	former	JJ
10_1101-2021_02_13_429885	102	3	is	be	VBZ
10_1101-2021_02_13_429885	102	4	based	base	VBN
10_1101-2021_02_13_429885	102	5	on	on	IN
10_1101-2021_02_13_429885	102	6	a	a	DT
10_1101-2021_02_13_429885	102	7	density	density	NN
10_1101-2021_02_13_429885	102	8	-	-	HYPH
10_1101-2021_02_13_429885	102	9	based	base	VBN
10_1101-2021_02_13_429885	102	10	analysis	analysis	NN
10_1101-2021_02_13_429885	102	11	of	of	IN
10_1101-2021_02_13_429885	102	12	the	the	DT
10_1101-2021_02_13_429885	102	13	VAF	VAF	NNP
10_1101-2021_02_13_429885	102	14	distribution	distribution	NN
10_1101-2021_02_13_429885	102	15	,	,	,
10_1101-2021_02_13_429885	102	16	and	and	CC
10_1101-2021_02_13_429885	102	17	uses	use	VBZ
10_1101-2021_02_13_429885	102	18	both	both	CC
10_1101-2021_02_13_429885	102	19	a	a	DT
10_1101-2021_02_13_429885	102	20	non	non	JJ
10_1101-2021_02_13_429885	102	21	-	-	JJ
10_1101-2021_02_13_429885	102	22	parametric	parametric	JJ
10_1101-2021_02_13_429885	102	23	kernel	kernel	NN
10_1101-2021_02_13_429885	102	24	density	density	NN
10_1101-2021_02_13_429885	102	25	and	and	CC
10_1101-2021_02_13_429885	102	26	a	a	DT
10_1101-2021_02_13_429885	102	27	univariate	univariate	JJ
10_1101-2021_02_13_429885	102	28	Binomial	Binomial	NNP
10_1101-2021_02_13_429885	102	29	mixture	mixture	NN
10_1101-2021_02_13_429885	102	30	to	to	TO
10_1101-2021_02_13_429885	102	31	match	match	VB
10_1101-2021_02_13_429885	102	32	peaks	peak	NNS
10_1101-2021_02_13_429885	102	33	in	in	IN
10_1101-2021_02_13_429885	102	34	the	the	DT
10_1101-2021_02_13_429885	102	35	VAF	VAF	NNP
10_1101-2021_02_13_429885	102	36	data	datum	NNS
10_1101-2021_02_13_429885	102	37	(	(	-LRB-
10_1101-2021_02_13_429885	102	38	​Figure	​Figure	NNP
10_1101-2021_02_13_429885	102	39	3a	3a	NNP
10_1101-2021_02_13_429885	102	40	-	-	HYPH
10_1101-2021_02_13_429885	102	41	d	d	NNP
10_1101-2021_02_13_429885	102	42	​	​	NNP
10_1101-2021_02_13_429885	102	43	)	)	-RRB-
10_1101-2021_02_13_429885	102	44	.	.	.
10_1101-2021_02_13_429885	103	1	The	the	DT
10_1101-2021_02_13_429885	103	2	latter	latter	NN
10_1101-2021_02_13_429885	103	3	is	be	VBZ
10_1101-2021_02_13_429885	103	4	based	base	VBN
10_1101-2021_02_13_429885	103	5	on	on	IN
10_1101-2021_02_13_429885	103	6	the	the	DT
10_1101-2021_02_13_429885	103	7	entropy	entropy	NN
10_1101-2021_02_13_429885	103	8	of	of	IN
10_1101-2021_02_13_429885	103	9	the	the	DT
10_1101-2021_02_13_429885	103	10	latent	latent	NN
10_1101-2021_02_13_429885	103	11	variables	variable	NNS
10_1101-2021_02_13_429885	103	12	in	in	IN
10_1101-2021_02_13_429885	103	13	a	a	DT
10_1101-2021_02_13_429885	103	14	Binomial	Binomial	NNP
10_1101-2021_02_13_429885	103	15	mixture	mixture	NN
10_1101-2021_02_13_429885	103	16	model	model	NN
10_1101-2021_02_13_429885	103	17	,	,	,
10_1101-2021_02_13_429885	103	18	whose	whose	WP$
10_1101-2021_02_13_429885	103	19	components	component	NNS
10_1101-2021_02_13_429885	103	20	are	be	VBP
10_1101-2021_02_13_429885	103	21	peaked	peak	VBN
10_1101-2021_02_13_429885	103	22	at	at	IN
10_1101-2021_02_13_429885	103	23	the	the	DT
10_1101-2021_02_13_429885	103	24	expected	expect	VBN
10_1101-2021_02_13_429885	103	25	VAF	VAF	NNP
10_1101-2021_02_13_429885	103	26	.	.	.
10_1101-2021_02_13_429885	104	1	From	from	IN
10_1101-2021_02_13_429885	104	2	this	this	DT
10_1101-2021_02_13_429885	104	3	density	density	NN
10_1101-2021_02_13_429885	104	4	we	-PRON-	PRP
10_1101-2021_02_13_429885	104	5	identify	identify	VBP
10_1101-2021_02_13_429885	104	6	VAF	VAF	NNP
10_1101-2021_02_13_429885	104	7	ranges	range	VBZ
10_1101-2021_02_13_429885	104	8	for	for	IN
10_1101-2021_02_13_429885	104	9	which	which	WDT
10_1101-2021_02_13_429885	104	10	it	-PRON-	PRP
10_1101-2021_02_13_429885	104	11	is	be	VBZ
10_1101-2021_02_13_429885	104	12	hard	hard	JJ
10_1101-2021_02_13_429885	104	13	to	to	TO
10_1101-2021_02_13_429885	104	14	estimate	estimate	VB
10_1101-2021_02_13_429885	104	15	the	the	DT
10_1101-2021_02_13_429885	104	16	mutation	mutation	NN
10_1101-2021_02_13_429885	104	17	multiplicity	multiplicity	NN
10_1101-2021_02_13_429885	104	18	,	,	,
10_1101-2021_02_13_429885	104	19	and	and	CC
10_1101-2021_02_13_429885	104	20	therefore	therefore	RB
10_1101-2021_02_13_429885	104	21	the	the	DT
10_1101-2021_02_13_429885	104	22	CCF	ccf	NN
10_1101-2021_02_13_429885	104	23	of	of	IN
10_1101-2021_02_13_429885	104	24	the	the	DT
10_1101-2021_02_13_429885	104	25	mutation	mutation	NN
10_1101-2021_02_13_429885	104	26	(	(	-LRB-
10_1101-2021_02_13_429885	104	27	​Figure	​Figure	NNP
10_1101-2021_02_13_429885	104	28	3e	3e	NN
10_1101-2021_02_13_429885	104	29	-	-	HYPH
10_1101-2021_02_13_429885	104	30	h	h	NN
10_1101-2021_02_13_429885	104	31	​	​	NN
10_1101-2021_02_13_429885	104	32	)	)	-RRB-
10_1101-2021_02_13_429885	104	33	.	.	.
10_1101-2021_02_13_429885	105	1	To	to	IN
10_1101-2021_02_13_429885	105	2	the	the	DT
10_1101-2021_02_13_429885	105	3	best	good	JJS
10_1101-2021_02_13_429885	105	4	of	of	IN
10_1101-2021_02_13_429885	105	5	our	-PRON-	PRP$
10_1101-2021_02_13_429885	105	6	understanding	understanding	NN
10_1101-2021_02_13_429885	105	7	,	,	,
10_1101-2021_02_13_429885	105	8	this	this	DT
10_1101-2021_02_13_429885	105	9	is	be	VBZ
10_1101-2021_02_13_429885	105	10	the	the	DT
10_1101-2021_02_13_429885	105	11	only	only	JJ
10_1101-2021_02_13_429885	105	12	framework	framework	NN
10_1101-2021_02_13_429885	105	13	providing	provide	VBG
10_1101-2021_02_13_429885	105	14	quantitative	quantitative	JJ
10_1101-2021_02_13_429885	105	15	metrics	metric	NNS
10_1101-2021_02_13_429885	105	16	for	for	IN
10_1101-2021_02_13_429885	105	17	all	all	PDT
10_1101-2021_02_13_429885	105	18	the	the	DT
10_1101-2021_02_13_429885	105	19	most	most	RBS
10_1101-2021_02_13_429885	105	20	widespread	widespread	JJ
10_1101-2021_02_13_429885	105	21	types	type	NNS
10_1101-2021_02_13_429885	105	22	of	of	IN
10_1101-2021_02_13_429885	105	23	tumour	tumour	NN
10_1101-2021_02_13_429885	105	24	mutations	mutation	NNS
10_1101-2021_02_13_429885	105	25	.	.	.
10_1101-2021_02_13_429885	106	1	Multi	multi	JJ
10_1101-2021_02_13_429885	106	2	-	-	JJ
10_1101-2021_02_13_429885	106	3	region	region	JJ
10_1101-2021_02_13_429885	106	4	colorectal	colorectal	JJ
10_1101-2021_02_13_429885	106	5	cancer	cancer	NN
10_1101-2021_02_13_429885	106	6	data	datum	NNS
10_1101-2021_02_13_429885	106	7	We	-PRON-	PRP
10_1101-2021_02_13_429885	106	8	have	have	VBP
10_1101-2021_02_13_429885	106	9	run	run	VBN
10_1101-2021_02_13_429885	106	10	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	106	11	on	on	IN
10_1101-2021_02_13_429885	106	12	previously	previously	RB
10_1101-2021_02_13_429885	106	13	published	publish	VBN
10_1101-2021_02_13_429885	106	14	WGS	WGS	NNP
10_1101-2021_02_13_429885	106	15	multi	multi	JJ
10_1101-2021_02_13_429885	106	16	-	-	JJ
10_1101-2021_02_13_429885	106	17	region	region	JJ
10_1101-2021_02_13_429885	106	18	data	datum	NNS
10_1101-2021_02_13_429885	106	19	​(Cross	​(Cross	NNP
10_1101-2021_02_13_429885	106	20	et	et	NNP
10_1101-2021_02_13_429885	106	21	al	al	NNP
10_1101-2021_02_13_429885	106	22	.	.	.
10_1101-2021_02_13_429885	107	1	10	10	CD
10_1101-2021_02_13_429885	107	2	2018	2018	CD
10_1101-2021_02_13_429885	107	3	;	;	:
10_1101-2021_02_13_429885	107	4	Caravagna	Caravagna	NNP
10_1101-2021_02_13_429885	107	5	et	et	NNP
10_1101-2021_02_13_429885	107	6	al	al	NNP
10_1101-2021_02_13_429885	107	7	.	.	.
10_1101-2021_02_13_429885	108	1	2020)​	2020)​	CD
10_1101-2021_02_13_429885	108	2	,	,	,
10_1101-2021_02_13_429885	108	3	which	which	WDT
10_1101-2021_02_13_429885	108	4	was	be	VBD
10_1101-2021_02_13_429885	108	5	collected	collect	VBN
10_1101-2021_02_13_429885	108	6	from	from	IN
10_1101-2021_02_13_429885	108	7	multiple	multiple	JJ
10_1101-2021_02_13_429885	108	8	regions	region	NNS
10_1101-2021_02_13_429885	108	9	of	of	IN
10_1101-2021_02_13_429885	108	10	primary	primary	JJ
10_1101-2021_02_13_429885	108	11	colorectal	colorectal	JJ
10_1101-2021_02_13_429885	108	12	adenocarcinomas	adenocarcinomas	NNP
10_1101-2021_02_13_429885	108	13	across	across	IN
10_1101-2021_02_13_429885	108	14	two	two	CD
10_1101-2021_02_13_429885	108	15	distinct	distinct	JJ
10_1101-2021_02_13_429885	108	16	patients	patient	NNS
10_1101-2021_02_13_429885	108	17	.	.	.
10_1101-2021_02_13_429885	109	1	For	for	IN
10_1101-2021_02_13_429885	109	2	all	all	PDT
10_1101-2021_02_13_429885	109	3	these	these	DT
10_1101-2021_02_13_429885	109	4	samples	sample	NNS
10_1101-2021_02_13_429885	109	5	we	-PRON-	PRP
10_1101-2021_02_13_429885	109	6	have	have	VBP
10_1101-2021_02_13_429885	109	7	high	high	JJ
10_1101-2021_02_13_429885	109	8	quality	quality	NN
10_1101-2021_02_13_429885	109	9	somatic	somatic	JJ
10_1101-2021_02_13_429885	109	10	mutation	mutation	NN
10_1101-2021_02_13_429885	109	11	calls	call	NNS
10_1101-2021_02_13_429885	109	12	​(Cross	​(Cross	NNP
10_1101-2021_02_13_429885	109	13	et	et	NNP
10_1101-2021_02_13_429885	109	14	al	al	NNP
10_1101-2021_02_13_429885	109	15	.	.	.
10_1101-2021_02_13_429885	110	1	10	10	CD
10_1101-2021_02_13_429885	110	2	2018	2018	CD
10_1101-2021_02_13_429885	110	3	)	)	-RRB-
10_1101-2021_02_13_429885	110	4	that	that	WDT
10_1101-2021_02_13_429885	110	5	were	be	VBD
10_1101-2021_02_13_429885	110	6	obtained	obtain	VBN
10_1101-2021_02_13_429885	110	7	using	use	VBG
10_1101-2021_02_13_429885	110	8	CloneHD	CloneHD	NNP
10_1101-2021_02_13_429885	110	9	​(Fischer	​(Fischer	NNP
10_1101-2021_02_13_429885	110	10	et	et	NNP
10_1101-2021_02_13_429885	110	11	al	al	NNP
10_1101-2021_02_13_429885	110	12	.	.	.
10_1101-2021_02_13_429885	111	1	2014)​.	2014)​.	LS
10_1101-2021_02_13_429885	112	1	We	-PRON-	PRP
10_1101-2021_02_13_429885	112	2	have	have	VBP
10_1101-2021_02_13_429885	112	3	re	re	VBN
10_1101-2021_02_13_429885	112	4	-	-	VBN
10_1101-2021_02_13_429885	112	5	called	call	VBN
10_1101-2021_02_13_429885	112	6	CNAs	cna	NNS
10_1101-2021_02_13_429885	112	7	with	with	IN
10_1101-2021_02_13_429885	112	8	the	the	DT
10_1101-2021_02_13_429885	112	9	Sequenza	Sequenza	NNP
10_1101-2021_02_13_429885	112	10	CNA	CNA	NNP
10_1101-2021_02_13_429885	112	11	caller	caller	NN
10_1101-2021_02_13_429885	112	12	(	(	-LRB-
10_1101-2021_02_13_429885	112	13	Favero	Favero	NNP
10_1101-2021_02_13_429885	112	14	et	et	NNP
10_1101-2021_02_13_429885	112	15	al	al	NNP
10_1101-2021_02_13_429885	112	16	.	.	.
10_1101-2021_02_13_429885	113	1	2015)​	2015)​	CD
10_1101-2021_02_13_429885	113	2	,	,	,
10_1101-2021_02_13_429885	113	3	and	and	CC
10_1101-2021_02_13_429885	113	4	sought	seek	VBD
10_1101-2021_02_13_429885	113	5	out	out	RP
10_1101-2021_02_13_429885	113	6	to	to	TO
10_1101-2021_02_13_429885	113	7	check	check	VB
10_1101-2021_02_13_429885	113	8	the	the	DT
10_1101-2021_02_13_429885	113	9	inferred	inferred	JJ
10_1101-2021_02_13_429885	113	10	copy	copy	NN
10_1101-2021_02_13_429885	113	11	states	state	NNS
10_1101-2021_02_13_429885	113	12	and	and	CC
10_1101-2021_02_13_429885	113	13	tumour	tumour	NN
10_1101-2021_02_13_429885	113	14	purity	purity	NN
10_1101-2021_02_13_429885	113	15	with	with	IN
10_1101-2021_02_13_429885	113	16	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	113	17	,	,	,
10_1101-2021_02_13_429885	113	18	along	along	IN
10_1101-2021_02_13_429885	113	19	with	with	IN
10_1101-2021_02_13_429885	113	20	SNVs	snv	NNS
10_1101-2021_02_13_429885	113	21	generated	generate	VBN
10_1101-2021_02_13_429885	113	22	by	by	IN
10_1101-2021_02_13_429885	113	23	Mutect2	Mutect2	NNP
10_1101-2021_02_13_429885	113	24	​(Benjamin	​(Benjamin	NNP
10_1101-2021_02_13_429885	113	25	et	et	NNP
10_1101-2021_02_13_429885	113	26	al	al	NNP
10_1101-2021_02_13_429885	113	27	.	.	.
10_1101-2021_02_13_429885	114	1	2019)​.	2019)​.	CD
10_1101-2021_02_13_429885	115	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	115	2	-	-	:
10_1101-2021_02_13_429885	115	3	BY	by	IN
10_1101-2021_02_13_429885	115	4	-	-	HYPH
10_1101-2021_02_13_429885	115	5	NC	NC	NNP
10_1101-2021_02_13_429885	115	6	-	-	HYPH
10_1101-2021_02_13_429885	115	7	ND	ND	NNP
10_1101-2021_02_13_429885	115	8	4.0	4.0	CD
10_1101-2021_02_13_429885	115	9	International	International	NNP
10_1101-2021_02_13_429885	115	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	115	11	under	under	IN
10_1101-2021_02_13_429885	115	12	a	a	DT
10_1101-2021_02_13_429885	115	13	(	(	-LRB-
10_1101-2021_02_13_429885	115	14	which	which	WDT
10_1101-2021_02_13_429885	115	15	was	be	VBD
10_1101-2021_02_13_429885	115	16	not	not	RB
10_1101-2021_02_13_429885	115	17	certified	certify	VBN
10_1101-2021_02_13_429885	115	18	by	by	IN
10_1101-2021_02_13_429885	115	19	peer	peer	NN
10_1101-2021_02_13_429885	115	20	review	review	NN
10_1101-2021_02_13_429885	115	21	)	)	-RRB-
10_1101-2021_02_13_429885	115	22	is	be	VBZ
10_1101-2021_02_13_429885	115	23	the	the	DT
10_1101-2021_02_13_429885	115	24	author	author	NN
10_1101-2021_02_13_429885	115	25	/	/	SYM
10_1101-2021_02_13_429885	115	26	funder	funder	NN
10_1101-2021_02_13_429885	115	27	,	,	,
10_1101-2021_02_13_429885	115	28	who	who	WP
10_1101-2021_02_13_429885	115	29	has	have	VBZ
10_1101-2021_02_13_429885	115	30	granted	grant	VBN
10_1101-2021_02_13_429885	115	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	115	32	a	a	DT
10_1101-2021_02_13_429885	115	33	license	license	NN
10_1101-2021_02_13_429885	115	34	to	to	TO
10_1101-2021_02_13_429885	115	35	display	display	VB
10_1101-2021_02_13_429885	115	36	the	the	DT
10_1101-2021_02_13_429885	115	37	preprint	preprint	NN
10_1101-2021_02_13_429885	115	38	in	in	IN
10_1101-2021_02_13_429885	115	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	115	40	.	.	.
10_1101-2021_02_13_429885	116	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	116	2	is	be	VBZ
10_1101-2021_02_13_429885	116	3	made	make	VBN
10_1101-2021_02_13_429885	116	4	The	the	DT
10_1101-2021_02_13_429885	116	5	copyright	copyright	NN
10_1101-2021_02_13_429885	116	6	holder	holder	NN
10_1101-2021_02_13_429885	116	7	for	for	IN
10_1101-2021_02_13_429885	116	8	this	this	DT
10_1101-2021_02_13_429885	116	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	116	10	version	version	NN
10_1101-2021_02_13_429885	116	11	posted	post	VBD
10_1101-2021_02_13_429885	116	12	February	February	NNP
10_1101-2021_02_13_429885	116	13	13	13	CD
10_1101-2021_02_13_429885	116	14	,	,	,
10_1101-2021_02_13_429885	116	15	2021	2021	CD
10_1101-2021_02_13_429885	116	16	.	.	.
10_1101-2021_02_13_429885	116	17	;	;	:
10_1101-2021_02_13_429885	116	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	116	19	:	:	:
10_1101-2021_02_13_429885	116	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	116	21	preprint	preprint	NN
10_1101-2021_02_13_429885	116	22	https://www.codecogs.com/eqnedit.php?latex=c%20%3D%20%5Cdfrac%7Bv%5B(p-2)%5Cpi%20%2B%202%5D%7D%7Bm%5Cpi%7D%20%5C%2C%20.#0	https://www.codecogs.com/eqnedit.php?latex=c%20%3d%20%5cdfrac%7bv%5b(p-2)%5cpi%20%2b%202%5d%7d%7bm%5cpi%7d%20%5c%2c%20.#0	NN
10_1101-2021_02_13_429885	116	23	https://www.zotero.org/google-docs/?YaP3DC	https://www.zotero.org/google-docs/?yap3dc	ADD
10_1101-2021_02_13_429885	116	24	https://paperpile.com/c/rqVmzs/IC0y+chqB	https://paperpile.com/c/rqvmzs/ic0y+chqb	ADD
10_1101-2021_02_13_429885	116	25	https://paperpile.com/c/rqVmzs/IC0y+chqB	https://paperpile.com/c/rqvmzs/ic0y+chqb	NN
10_1101-2021_02_13_429885	116	26	https://paperpile.com/c/rqVmzs/IC0y	https://paperpile.com/c/rqvmzs/ic0y	UH
10_1101-2021_02_13_429885	116	27	https://paperpile.com/c/rqVmzs/A7Vg	https://paperpile.com/c/rqVmzs/A7Vg	NNP
10_1101-2021_02_13_429885	116	28	https://paperpile.com/c/rqVmzs/tCb6	https://paperpile.com/c/rqvmzs/tcb6	UH
10_1101-2021_02_13_429885	116	29	https://paperpile.com/c/rqVmzs/bD5o	https://paperpile.com/c/rqVmzs/bD5o	NNP
10_1101-2021_02_13_429885	116	30	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	VBP
10_1101-2021_02_13_429885	116	31	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	116	32	Househam	Househam	NNP
10_1101-2021_02_13_429885	116	33	et	et	FW
10_1101-2021_02_13_429885	116	34	al	al	NNP
10_1101-2021_02_13_429885	116	35	.	.	.
10_1101-2021_02_13_429885	117	1	A	a	DT
10_1101-2021_02_13_429885	117	2	fully	fully	RB
10_1101-2021_02_13_429885	117	3	automated	automate	VBN
10_1101-2021_02_13_429885	117	4	approach	approach	NN
10_1101-2021_02_13_429885	117	5	for	for	IN
10_1101-2021_02_13_429885	117	6	quality	quality	NN
10_1101-2021_02_13_429885	117	7	control	control	NN
10_1101-2021_02_13_429885	117	8	of	of	IN
10_1101-2021_02_13_429885	117	9	cancer	cancer	NN
10_1101-2021_02_13_429885	117	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	117	11	in	in	IN
10_1101-2021_02_13_429885	117	12	the	the	DT
10_1101-2021_02_13_429885	117	13	era	era	NN
10_1101-2021_02_13_429885	117	14	of	of	IN
10_1101-2021_02_13_429885	117	15	high	high	JJ
10_1101-2021_02_13_429885	117	16	-	-	HYPH
10_1101-2021_02_13_429885	117	17	resolution	resolution	NN
10_1101-2021_02_13_429885	117	18	whole	whole	JJ
10_1101-2021_02_13_429885	117	19	genome	genome	JJ
10_1101-2021_02_13_429885	117	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	117	21	.	.	.
10_1101-2021_02_13_429885	118	1	Sequenza	Sequenza	NNP
10_1101-2021_02_13_429885	118	2	was	be	VBD
10_1101-2021_02_13_429885	118	3	run	run	VBN
10_1101-2021_02_13_429885	118	4	using	use	VBG
10_1101-2021_02_13_429885	118	5	distinct	distinct	JJ
10_1101-2021_02_13_429885	118	6	parameterizations	parameterization	NNS
10_1101-2021_02_13_429885	118	7	.	.	.
10_1101-2021_02_13_429885	119	1	We	-PRON-	PRP
10_1101-2021_02_13_429885	119	2	begun	begin	VBD
10_1101-2021_02_13_429885	119	3	with	with	IN
10_1101-2021_02_13_429885	119	4	the	the	DT
10_1101-2021_02_13_429885	119	5	default	default	NN
10_1101-2021_02_13_429885	119	6	range	range	NN
10_1101-2021_02_13_429885	119	7	proposals	proposal	NNS
10_1101-2021_02_13_429885	119	8	for	for	IN
10_1101-2021_02_13_429885	119	9	purity	purity	NN
10_1101-2021_02_13_429885	119	10	and	and	CC
10_1101-2021_02_13_429885	119	11	ploidy	ploidy	NN
10_1101-2021_02_13_429885	119	12	,	,	,
10_1101-2021_02_13_429885	119	13	which	which	WDT
10_1101-2021_02_13_429885	119	14	we	-PRON-	PRP
10_1101-2021_02_13_429885	119	15	then	then	RB
10_1101-2021_02_13_429885	119	16	improved	improve	VBD
10_1101-2021_02_13_429885	119	17	in	in	IN
10_1101-2021_02_13_429885	119	18	a	a	DT
10_1101-2021_02_13_429885	119	19	final	final	JJ
10_1101-2021_02_13_429885	119	20	run	run	NN
10_1101-2021_02_13_429885	119	21	following	follow	VBG
10_1101-2021_02_13_429885	119	22	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	119	23	1	1	CD
10_1101-2021_02_13_429885	119	24	analysis	analysis	NN
10_1101-2021_02_13_429885	119	25	.	.	.
10_1101-2021_02_13_429885	120	1	We	-PRON-	PRP
10_1101-2021_02_13_429885	120	2	also	also	RB
10_1101-2021_02_13_429885	120	3	forced	force	VBD
10_1101-2021_02_13_429885	120	4	a	a	DT
10_1101-2021_02_13_429885	120	5	Sequenza	Sequenza	NNP
10_1101-2021_02_13_429885	120	6	fit	fit	NN
10_1101-2021_02_13_429885	120	7	with	with	IN
10_1101-2021_02_13_429885	120	8	constrained	constrained	JJ
10_1101-2021_02_13_429885	120	9	tetraploid	tetraploid	NN
10_1101-2021_02_13_429885	120	10	genome	genome	JJ
10_1101-2021_02_13_429885	120	11	(	(	-LRB-
10_1101-2021_02_13_429885	120	12	ploidy	ploidy	NN
10_1101-2021_02_13_429885	120	13	equal	equal	NNP
10_1101-2021_02_13_429885	120	14	4	4	CD
10_1101-2021_02_13_429885	120	15	)	)	-RRB-
10_1101-2021_02_13_429885	120	16	,	,	,
10_1101-2021_02_13_429885	120	17	and	and	CC
10_1101-2021_02_13_429885	120	18	one	one	CD
10_1101-2021_02_13_429885	120	19	with	with	IN
10_1101-2021_02_13_429885	120	20	low	low	JJ
10_1101-2021_02_13_429885	120	21	purity	purity	NN
10_1101-2021_02_13_429885	120	22	.	.	.
10_1101-2021_02_13_429885	121	1	All	all	PDT
10_1101-2021_02_13_429885	121	2	these	these	DT
10_1101-2021_02_13_429885	121	3	steps	step	NNS
10_1101-2021_02_13_429885	121	4	could	could	MD
10_1101-2021_02_13_429885	121	5	have	have	VB
10_1101-2021_02_13_429885	121	6	been	be	VBN
10_1101-2021_02_13_429885	121	7	easily	easily	RB
10_1101-2021_02_13_429885	121	8	automatised	automatise	VBN
10_1101-2021_02_13_429885	121	9	in	in	IN
10_1101-2021_02_13_429885	121	10	a	a	DT
10_1101-2021_02_13_429885	121	11	procedure	procedure	NN
10_1101-2021_02_13_429885	121	12	that	that	WDT
10_1101-2021_02_13_429885	121	13	runs	run	VBZ
10_1101-2021_02_13_429885	121	14	the	the	DT
10_1101-2021_02_13_429885	121	15	caller	caller	NN
10_1101-2021_02_13_429885	121	16	,	,	,
10_1101-2021_02_13_429885	121	17	obtains	obtain	NNS
10_1101-2021_02_13_429885	121	18	score	score	VBP
10_1101-2021_02_13_429885	121	19	metrics	metric	NNS
10_1101-2021_02_13_429885	121	20	for	for	IN
10_1101-2021_02_13_429885	121	21	the	the	DT
10_1101-2021_02_13_429885	121	22	solution	solution	NN
10_1101-2021_02_13_429885	121	23	from	from	IN
10_1101-2021_02_13_429885	121	24	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	121	25	,	,	,
10_1101-2021_02_13_429885	121	26	and	and	CC
10_1101-2021_02_13_429885	121	27	re	re	VB
10_1101-2021_02_13_429885	121	28	-	-	VB
10_1101-2021_02_13_429885	121	29	run	run	VB
10_1101-2021_02_13_429885	121	30	the	the	DT
10_1101-2021_02_13_429885	121	31	fits	fit	NNS
10_1101-2021_02_13_429885	121	32	with	with	IN
10_1101-2021_02_13_429885	121	33	adjusted	adjusted	JJ
10_1101-2021_02_13_429885	121	34	parameters	parameter	NNS
10_1101-2021_02_13_429885	121	35	if	if	IN
10_1101-2021_02_13_429885	121	36	required	require	VBN
10_1101-2021_02_13_429885	121	37	.	.	.
10_1101-2021_02_13_429885	122	1	The	the	DT
10_1101-2021_02_13_429885	122	2	results	result	NNS
10_1101-2021_02_13_429885	122	3	for	for	IN
10_1101-2021_02_13_429885	122	4	one	one	CD
10_1101-2021_02_13_429885	122	5	sample	sample	NN
10_1101-2021_02_13_429885	122	6	of	of	IN
10_1101-2021_02_13_429885	122	7	patient	patient	JJ
10_1101-2021_02_13_429885	122	8	Set7	Set7	NNP
10_1101-2021_02_13_429885	122	9	-	-	HYPH
10_1101-2021_02_13_429885	122	10	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	122	11	7	7	CD
10_1101-2021_02_13_429885	122	12	in	in	IN
10_1101-2021_02_13_429885	122	13	the	the	DT
10_1101-2021_02_13_429885	122	14	original	original	JJ
10_1101-2021_02_13_429885	122	15	manuscript	manuscript	NN
10_1101-2021_02_13_429885	122	16	​(Cross	​(Cross	NNP
10_1101-2021_02_13_429885	122	17	et	et	NNP
10_1101-2021_02_13_429885	122	18	al	al	NNP
10_1101-2021_02_13_429885	122	19	.	.	.
10_1101-2021_02_13_429885	123	1	10	10	CD
10_1101-2021_02_13_429885	123	2	2018	2018	CD
10_1101-2021_02_13_429885	123	3	)	)	-RRB-
10_1101-2021_02_13_429885	123	4	-	-	:
10_1101-2021_02_13_429885	123	5	are	be	VBP
10_1101-2021_02_13_429885	123	6	in	in	IN
10_1101-2021_02_13_429885	123	7	​Figure	​figure	NN
10_1101-2021_02_13_429885	123	8	4	4	CD
10_1101-2021_02_13_429885	123	9	​	​	JJ
10_1101-2021_02_13_429885	123	10	;	;	:
10_1101-2021_02_13_429885	123	11	the	the	DT
10_1101-2021_02_13_429885	123	12	other	other	JJ
10_1101-2021_02_13_429885	123	13	samples	sample	NNS
10_1101-2021_02_13_429885	123	14	for	for	IN
10_1101-2021_02_13_429885	123	15	patient	patient	NN
10_1101-2021_02_13_429885	123	16	Set7	Set7	NNP
10_1101-2021_02_13_429885	123	17	are	be	VBP
10_1101-2021_02_13_429885	123	18	in	in	IN
10_1101-2021_02_13_429885	123	19	​Supplementary	​Supplementary	NNP
10_1101-2021_02_13_429885	123	20	Figures	Figures	NNPS
10_1101-2021_02_13_429885	123	21	S2-S4	S2-S4	NNP
10_1101-2021_02_13_429885	123	22	​.	​.	NN
10_1101-2021_02_13_429885	124	1	All	all	DT
10_1101-2021_02_13_429885	124	2	samples	sample	NNS
10_1101-2021_02_13_429885	124	3	for	for	IN
10_1101-2021_02_13_429885	124	4	patient	patient	NN
10_1101-2021_02_13_429885	124	5	Set6	Set6	NNP
10_1101-2021_02_13_429885	124	6	are	be	VBP
10_1101-2021_02_13_429885	124	7	in	in	IN
10_1101-2021_02_13_429885	124	8	​Supplementary	​supplementary	JJ
10_1101-2021_02_13_429885	124	9	Figures	figure	NNS
10_1101-2021_02_13_429885	124	10	S5-S10	S5-S10	NNP
10_1101-2021_02_13_429885	124	11	.	.	.
10_1101-2021_02_13_429885	125	1	The	the	DT
10_1101-2021_02_13_429885	125	2	peak	peak	NN
10_1101-2021_02_13_429885	125	3	detection	detection	NN
10_1101-2021_02_13_429885	125	4	scores	score	NNS
10_1101-2021_02_13_429885	125	5	produced	produce	VBN
10_1101-2021_02_13_429885	125	6	by	by	IN
10_1101-2021_02_13_429885	125	7	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	125	8	invariably	invariably	RB
10_1101-2021_02_13_429885	125	9	fail	fail	VBP
10_1101-2021_02_13_429885	125	10	both	both	CC
10_1101-2021_02_13_429885	125	11	the	the	DT
10_1101-2021_02_13_429885	125	12	tetraploid	tetraploid	NN
10_1101-2021_02_13_429885	125	13	and	and	CC
10_1101-2021_02_13_429885	125	14	low	low	JJ
10_1101-2021_02_13_429885	125	15	-	-	HYPH
10_1101-2021_02_13_429885	125	16	purity	purity	NN
10_1101-2021_02_13_429885	125	17	solutions	solution	NNS
10_1101-2021_02_13_429885	125	18	,	,	,
10_1101-2021_02_13_429885	125	19	passing	pass	VBG
10_1101-2021_02_13_429885	125	20	the	the	DT
10_1101-2021_02_13_429885	125	21	others	other	NNS
10_1101-2021_02_13_429885	125	22	;	;	:
10_1101-2021_02_13_429885	125	23	the	the	DT
10_1101-2021_02_13_429885	125	24	little	little	JJ
10_1101-2021_02_13_429885	125	25	adjustment	adjustment	NN
10_1101-2021_02_13_429885	125	26	suggested	suggest	VBD
10_1101-2021_02_13_429885	125	27	to	to	IN
10_1101-2021_02_13_429885	125	28	the	the	DT
10_1101-2021_02_13_429885	125	29	default	default	NN
10_1101-2021_02_13_429885	125	30	parameters	parameter	NNS
10_1101-2021_02_13_429885	125	31	slightly	slightly	RB
10_1101-2021_02_13_429885	125	32	improves	improve	VBZ
10_1101-2021_02_13_429885	125	33	the	the	DT
10_1101-2021_02_13_429885	125	34	purity	purity	NN
10_1101-2021_02_13_429885	125	35	,	,	,
10_1101-2021_02_13_429885	125	36	but	but	CC
10_1101-2021_02_13_429885	125	37	the	the	DT
10_1101-2021_02_13_429885	125	38	overall	overall	JJ
10_1101-2021_02_13_429885	125	39	quality	quality	NN
10_1101-2021_02_13_429885	125	40	is	be	VBZ
10_1101-2021_02_13_429885	125	41	high	high	JJ
10_1101-2021_02_13_429885	125	42	even	even	RB
10_1101-2021_02_13_429885	125	43	with	with	IN
10_1101-2021_02_13_429885	125	44	just	just	RB
10_1101-2021_02_13_429885	125	45	default	default	NN
10_1101-2021_02_13_429885	125	46	parameters	parameter	NNS
10_1101-2021_02_13_429885	125	47	(	(	-LRB-
10_1101-2021_02_13_429885	125	48	​Figure	​figure	NN
10_1101-2021_02_13_429885	125	49	4b	4b	NNS
10_1101-2021_02_13_429885	125	50	​	​	JJ
10_1101-2021_02_13_429885	125	51	)	)	-RRB-
10_1101-2021_02_13_429885	125	52	.	.	.
10_1101-2021_02_13_429885	126	1	The	the	DT
10_1101-2021_02_13_429885	126	2	whole	whole	JJ
10_1101-2021_02_13_429885	126	3	-	-	HYPH
10_1101-2021_02_13_429885	126	4	genome	genome	JJ
10_1101-2021_02_13_429885	126	5	CNA	cna	NN
10_1101-2021_02_13_429885	126	6	profile	profile	NN
10_1101-2021_02_13_429885	126	7	for	for	IN
10_1101-2021_02_13_429885	126	8	this	this	DT
10_1101-2021_02_13_429885	126	9	sample	sample	NN
10_1101-2021_02_13_429885	126	10	shows	show	VBZ
10_1101-2021_02_13_429885	126	11	some	some	DT
10_1101-2021_02_13_429885	126	12	degree	degree	NN
10_1101-2021_02_13_429885	126	13	of	of	IN
10_1101-2021_02_13_429885	126	14	aneuploidy	aneuploidy	NNP
10_1101-2021_02_13_429885	126	15	(	(	-LRB-
10_1101-2021_02_13_429885	126	16	​Figure	​figure	NN
10_1101-2021_02_13_429885	126	17	4c	4c	CD
10_1101-2021_02_13_429885	126	18	​	​	JJ
10_1101-2021_02_13_429885	126	19	)	)	-RRB-
10_1101-2021_02_13_429885	126	20	,	,	,
10_1101-2021_02_13_429885	126	21	and	and	CC
10_1101-2021_02_13_429885	126	22	it	-PRON-	PRP
10_1101-2021_02_13_429885	126	23	is	be	VBZ
10_1101-2021_02_13_429885	126	24	easy	easy	JJ
10_1101-2021_02_13_429885	126	25	with	with	IN
10_1101-2021_02_13_429885	126	26	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	126	27	to	to	TO
10_1101-2021_02_13_429885	126	28	assess	assess	VB
10_1101-2021_02_13_429885	126	29	miscalled	miscall	VBN
10_1101-2021_02_13_429885	126	30	CNA	CNA	NNP
10_1101-2021_02_13_429885	126	31	segments	segment	NNS
10_1101-2021_02_13_429885	126	32	ahead	ahead	RB
10_1101-2021_02_13_429885	126	33	of	of	IN
10_1101-2021_02_13_429885	126	34	the	the	DT
10_1101-2021_02_13_429885	126	35	VAF	VAF	NNP
10_1101-2021_02_13_429885	126	36	data	datum	NNS
10_1101-2021_02_13_429885	126	37	(	(	-LRB-
10_1101-2021_02_13_429885	126	38	​Figure	​figure	NN
10_1101-2021_02_13_429885	126	39	4d	4d	NNS
10_1101-2021_02_13_429885	126	40	​	​	JJ
10_1101-2021_02_13_429885	126	41	)	)	-RRB-
10_1101-2021_02_13_429885	126	42	.	.	.
10_1101-2021_02_13_429885	127	1	The	the	DT
10_1101-2021_02_13_429885	127	2	analysis	analysis	NN
10_1101-2021_02_13_429885	127	3	of	of	IN
10_1101-2021_02_13_429885	127	4	all	all	PDT
10_1101-2021_02_13_429885	127	5	the	the	DT
10_1101-2021_02_13_429885	127	6	samples	sample	NNS
10_1101-2021_02_13_429885	127	7	available	available	JJ
10_1101-2021_02_13_429885	127	8	for	for	IN
10_1101-2021_02_13_429885	127	9	Set7	Set7	NNP
10_1101-2021_02_13_429885	127	10	shows	show	VBZ
10_1101-2021_02_13_429885	127	11	an	an	DT
10_1101-2021_02_13_429885	127	12	overall	overall	JJ
10_1101-2021_02_13_429885	127	13	CNA	cna	NN
10_1101-2021_02_13_429885	127	14	profile	profile	NN
10_1101-2021_02_13_429885	127	15	with	with	IN
10_1101-2021_02_13_429885	127	16	many	many	JJ
10_1101-2021_02_13_429885	127	17	diploid	diploid	JJ
10_1101-2021_02_13_429885	127	18	regions	region	NNS
10_1101-2021_02_13_429885	127	19	and	and	CC
10_1101-2021_02_13_429885	127	20	mild	mild	JJ
10_1101-2021_02_13_429885	127	21	aneuploidy	aneuploidy	NN
10_1101-2021_02_13_429885	127	22	(	(	-LRB-
10_1101-2021_02_13_429885	127	23	​Figure	​figure	NN
10_1101-2021_02_13_429885	127	24	4e	4e	NN
10_1101-2021_02_13_429885	127	25	​	​	JJ
10_1101-2021_02_13_429885	127	26	)	)	-RRB-
10_1101-2021_02_13_429885	127	27	,	,	,
10_1101-2021_02_13_429885	127	28	consistent	consistent	JJ
10_1101-2021_02_13_429885	127	29	with	with	IN
10_1101-2021_02_13_429885	127	30	a	a	DT
10_1101-2021_02_13_429885	127	31	microsatellite	microsatellite	JJ
10_1101-2021_02_13_429885	127	32	stable	stable	JJ
10_1101-2021_02_13_429885	127	33	colorectal	colorectal	JJ
10_1101-2021_02_13_429885	127	34	cancer	cancer	NN
10_1101-2021_02_13_429885	127	35	​(Cross	​(Cross	NNP
10_1101-2021_02_13_429885	127	36	et	et	NNP
10_1101-2021_02_13_429885	127	37	al	al	NNP
10_1101-2021_02_13_429885	127	38	.	.	.
10_1101-2021_02_13_429885	128	1	10	10	CD
10_1101-2021_02_13_429885	128	2	2018)​.	2018)​.	CD
10_1101-2021_02_13_429885	129	1	Large	large	JJ
10_1101-2021_02_13_429885	129	2	-	-	HYPH
10_1101-2021_02_13_429885	129	3	scale	scale	NN
10_1101-2021_02_13_429885	129	4	pan	pan	NN
10_1101-2021_02_13_429885	129	5	cancer	cancer	NN
10_1101-2021_02_13_429885	129	6	PCAWG	PCAWG	NNP
10_1101-2021_02_13_429885	129	7	calls	call	VBZ
10_1101-2021_02_13_429885	129	8	We	-PRON-	PRP
10_1101-2021_02_13_429885	129	9	have	have	VBP
10_1101-2021_02_13_429885	129	10	run	run	VBN
10_1101-2021_02_13_429885	129	11	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	129	12	on	on	IN
10_1101-2021_02_13_429885	129	13	a	a	DT
10_1101-2021_02_13_429885	129	14	subset	subset	NN
10_1101-2021_02_13_429885	129	15	of	of	IN
10_1101-2021_02_13_429885	129	16	the	the	DT
10_1101-2021_02_13_429885	129	17	full	full	JJ
10_1101-2021_02_13_429885	129	18	PCAWG	PCAWG	NNP
10_1101-2021_02_13_429885	129	19	cohort	cohort	NN
10_1101-2021_02_13_429885	129	20	,	,	,
10_1101-2021_02_13_429885	129	21	which	which	WDT
10_1101-2021_02_13_429885	129	22	contains	contain	VBZ
10_1101-2021_02_13_429885	129	23	thousands	thousand	NNS
10_1101-2021_02_13_429885	129	24	of	of	IN
10_1101-2021_02_13_429885	129	25	samples	sample	NNS
10_1101-2021_02_13_429885	129	26	from	from	IN
10_1101-2021_02_13_429885	129	27	multiple	multiple	JJ
10_1101-2021_02_13_429885	129	28	tumour	tumour	NN
10_1101-2021_02_13_429885	129	29	types	type	NNS
10_1101-2021_02_13_429885	129	30	​(Campbell	​(campbell	VBP
10_1101-2021_02_13_429885	129	31	et	et	FW
10_1101-2021_02_13_429885	129	32	al	al	NNP
10_1101-2021_02_13_429885	129	33	.	.	.
10_1101-2021_02_13_429885	130	1	2020)​.	2020)​.	CD
10_1101-2021_02_13_429885	131	1	The	the	DT
10_1101-2021_02_13_429885	131	2	median	median	JJ
10_1101-2021_02_13_429885	131	3	coverage	coverage	NN
10_1101-2021_02_13_429885	131	4	of	of	IN
10_1101-2021_02_13_429885	131	5	this	this	DT
10_1101-2021_02_13_429885	131	6	cohort	cohort	NN
10_1101-2021_02_13_429885	131	7	is	be	VBZ
10_1101-2021_02_13_429885	131	8	45x	45x	NNS
10_1101-2021_02_13_429885	131	9	,	,	,
10_1101-2021_02_13_429885	131	10	with	with	IN
10_1101-2021_02_13_429885	131	11	purity	purity	NN
10_1101-2021_02_13_429885	131	12	~65	~65	NFP
10_1101-2021_02_13_429885	131	13	%	%	NN
10_1101-2021_02_13_429885	131	14	​(Caravagna	​(Caravagna	NNP
10_1101-2021_02_13_429885	131	15	et	et	NNP
10_1101-2021_02_13_429885	131	16	al	al	NNP
10_1101-2021_02_13_429885	131	17	.	.	.
10_1101-2021_02_13_429885	132	1	2020)​	2020)​	CD
10_1101-2021_02_13_429885	132	2	;	;	:
10_1101-2021_02_13_429885	132	3	a	a	DT
10_1101-2021_02_13_429885	132	4	much	much	RB
10_1101-2021_02_13_429885	132	5	lower	low	JJR
10_1101-2021_02_13_429885	132	6	resolution	resolution	NN
10_1101-2021_02_13_429885	132	7	than	than	IN
10_1101-2021_02_13_429885	132	8	the	the	DT
10_1101-2021_02_13_429885	132	9	data	datum	NNS
10_1101-2021_02_13_429885	132	10	available	available	JJ
10_1101-2021_02_13_429885	132	11	for	for	IN
10_1101-2021_02_13_429885	132	12	the	the	DT
10_1101-2021_02_13_429885	132	13	multi	multi	JJ
10_1101-2021_02_13_429885	132	14	-	-	JJ
10_1101-2021_02_13_429885	132	15	region	region	JJ
10_1101-2021_02_13_429885	132	16	samples	sample	NNS
10_1101-2021_02_13_429885	132	17	discussed	discuss	VBN
10_1101-2021_02_13_429885	132	18	in	in	IN
10_1101-2021_02_13_429885	132	19	the	the	DT
10_1101-2021_02_13_429885	132	20	previous	previous	JJ
10_1101-2021_02_13_429885	132	21	section	section	NN
10_1101-2021_02_13_429885	132	22	.	.	.
10_1101-2021_02_13_429885	133	1	Because	because	IN
10_1101-2021_02_13_429885	133	2	of	of	IN
10_1101-2021_02_13_429885	133	3	this	this	DT
10_1101-2021_02_13_429885	133	4	,	,	,
10_1101-2021_02_13_429885	133	5	peak	peak	VB
10_1101-2021_02_13_429885	133	6	detection	detection	NN
10_1101-2021_02_13_429885	133	7	from	from	IN
10_1101-2021_02_13_429885	133	8	the	the	DT
10_1101-2021_02_13_429885	133	9	VAF	VAF	NNP
10_1101-2021_02_13_429885	133	10	distribution	distribution	NN
10_1101-2021_02_13_429885	133	11	across	across	IN
10_1101-2021_02_13_429885	133	12	some	some	DT
10_1101-2021_02_13_429885	133	13	of	of	IN
10_1101-2021_02_13_429885	133	14	the	the	DT
10_1101-2021_02_13_429885	133	15	samples	sample	NNS
10_1101-2021_02_13_429885	133	16	would	would	MD
10_1101-2021_02_13_429885	133	17	be	be	VB
10_1101-2021_02_13_429885	133	18	challenged	challenge	VBN
10_1101-2021_02_13_429885	133	19	by	by	IN
10_1101-2021_02_13_429885	133	20	signal	signal	JJ
10_1101-2021_02_13_429885	133	21	quality	quality	NN
10_1101-2021_02_13_429885	133	22	;	;	:
10_1101-2021_02_13_429885	133	23	in	in	IN
10_1101-2021_02_13_429885	133	24	practice	practice	NN
10_1101-2021_02_13_429885	133	25	,	,	,
10_1101-2021_02_13_429885	133	26	for	for	IN
10_1101-2021_02_13_429885	133	27	genomes	genome	NNS
10_1101-2021_02_13_429885	133	28	with	with	IN
10_1101-2021_02_13_429885	133	29	complex	complex	JJ
10_1101-2021_02_13_429885	133	30	aneuploidy	aneuploidy	NN
10_1101-2021_02_13_429885	133	31	and	and	CC
10_1101-2021_02_13_429885	133	32	massive	massive	JJ
10_1101-2021_02_13_429885	133	33	drops	drop	NNS
10_1101-2021_02_13_429885	133	34	in	in	IN
10_1101-2021_02_13_429885	133	35	purity	purity	NN
10_1101-2021_02_13_429885	133	36	and	and	CC
10_1101-2021_02_13_429885	133	37	coverage	coverage	VB
10_1101-2021_02_13_429885	133	38	the	the	DT
10_1101-2021_02_13_429885	133	39	VAF	VAF	NNP
10_1101-2021_02_13_429885	133	40	distribution	distribution	NN
10_1101-2021_02_13_429885	133	41	is	be	VBZ
10_1101-2021_02_13_429885	133	42	unsuitable	unsuitable	JJ
10_1101-2021_02_13_429885	133	43	for	for	IN
10_1101-2021_02_13_429885	133	44	peak	peak	NN
10_1101-2021_02_13_429885	133	45	-	-	HYPH
10_1101-2021_02_13_429885	133	46	detection	detection	NN
10_1101-2021_02_13_429885	133	47	,	,	,
10_1101-2021_02_13_429885	133	48	leading	lead	VBG
10_1101-2021_02_13_429885	133	49	to	to	IN
10_1101-2021_02_13_429885	133	50	false	false	JJ
10_1101-2021_02_13_429885	133	51	-	-	HYPH
10_1101-2021_02_13_429885	133	52	positives	positive	NNS
10_1101-2021_02_13_429885	133	53	in	in	IN
10_1101-2021_02_13_429885	133	54	the	the	DT
10_1101-2021_02_13_429885	133	55	QC	QC	NNP
10_1101-2021_02_13_429885	133	56	process	process	NN
10_1101-2021_02_13_429885	133	57	.	.	.
10_1101-2021_02_13_429885	134	1	To	to	TO
10_1101-2021_02_13_429885	134	2	avoid	avoid	VB
10_1101-2021_02_13_429885	134	3	this	this	DT
10_1101-2021_02_13_429885	134	4	and	and	CC
10_1101-2021_02_13_429885	134	5	work	work	VB
10_1101-2021_02_13_429885	134	6	with	with	IN
10_1101-2021_02_13_429885	134	7	suitable	suitable	JJ
10_1101-2021_02_13_429885	134	8	samples	sample	NNS
10_1101-2021_02_13_429885	134	9	,	,	,
10_1101-2021_02_13_429885	134	10	we	-PRON-	PRP
10_1101-2021_02_13_429885	134	11	identified	identify	VBD
10_1101-2021_02_13_429885	134	12	cases	case	NNS
10_1101-2021_02_13_429885	134	13	adopting	adopt	VBG
10_1101-2021_02_13_429885	134	14	the	the	DT
10_1101-2021_02_13_429885	134	15	following	following	JJ
10_1101-2021_02_13_429885	134	16	conditions	condition	NNS
10_1101-2021_02_13_429885	134	17	:	:	:
10_1101-2021_02_13_429885	134	18	(	(	-LRB-
10_1101-2021_02_13_429885	134	19	i	i	NN
10_1101-2021_02_13_429885	134	20	)	)	-RRB-
10_1101-2021_02_13_429885	134	21	the	the	DT
10_1101-2021_02_13_429885	134	22	065n	065n	NNPS
10_1101-2021_02_13_429885	134	23	=	=	SYM
10_1101-2021_02_13_429885	134	24	1	1	CD
10_1101-2021_02_13_429885	134	25	tumour	tumour	NN
10_1101-2021_02_13_429885	134	26	type	type	NN
10_1101-2021_02_13_429885	134	27	contains	contain	VBZ
10_1101-2021_02_13_429885	134	28	>	>	NFP
10_1101-2021_02_13_429885	134	29	20	20	CD
10_1101-2021_02_13_429885	134	30	samples	sample	NNS
10_1101-2021_02_13_429885	134	31	,	,	,
10_1101-2021_02_13_429885	134	32	(	(	-LRB-
10_1101-2021_02_13_429885	134	33	ii	ii	LS
10_1101-2021_02_13_429885	134	34	)	)	-RRB-
10_1101-2021_02_13_429885	134	35	the	the	DT
10_1101-2021_02_13_429885	134	36	tumour	tumour	NN
10_1101-2021_02_13_429885	134	37	genome	genome	NN
10_1101-2021_02_13_429885	134	38	used	use	VBN
10_1101-2021_02_13_429885	134	39	for	for	IN
10_1101-2021_02_13_429885	134	40	QC	QC	NNP
10_1101-2021_02_13_429885	134	41	contains	contain	VBZ
10_1101-2021_02_13_429885	134	42	>	>	XX
10_1101-2021_02_13_429885	134	43	30	30	CD
10_1101-2021_02_13_429885	134	44	%	%	NN
10_1101-2021_02_13_429885	134	45	of	of	IN
10_1101-2021_02_13_429885	134	46	the	the	DT
10_1101-2021_02_13_429885	134	47	overall	overall	JJ
10_1101-2021_02_13_429885	134	48	SNVs	SNVs	NNPS
10_1101-2021_02_13_429885	134	49	in	in	IN
10_1101-2021_02_13_429885	134	50	the	the	DT
10_1101-2021_02_13_429885	134	51	tumour	tumour	NN
10_1101-2021_02_13_429885	134	52	-	-	,
10_1101-2021_02_13_429885	134	53	so	so	IN
10_1101-2021_02_13_429885	134	54	a	a	DT
10_1101-2021_02_13_429885	134	55	substantial	substantial	JJ
10_1101-2021_02_13_429885	134	56	part	part	NN
10_1101-2021_02_13_429885	134	57	of	of	IN
10_1101-2021_02_13_429885	134	58	the	the	DT
10_1101-2021_02_13_429885	134	59	overall	overall	JJ
10_1101-2021_02_13_429885	134	60	mutational	mutational	JJ
10_1101-2021_02_13_429885	134	61	burden	burden	NN
10_1101-2021_02_13_429885	134	62	-	-	:
10_1101-2021_02_13_429885	134	63	and	and	CC
10_1101-2021_02_13_429885	134	64	(	(	-LRB-
10_1101-2021_02_13_429885	134	65	iii	iii	NN
10_1101-2021_02_13_429885	134	66	)	)	-RRB-
10_1101-2021_02_13_429885	134	67	the	the	DT
10_1101-2021_02_13_429885	134	68	purity	purity	NN
10_1101-2021_02_13_429885	134	69	of	of	IN
10_1101-2021_02_13_429885	134	70	the	the	DT
10_1101-2021_02_13_429885	134	71	sample	sample	NN
10_1101-2021_02_13_429885	134	72	is	be	VBZ
10_1101-2021_02_13_429885	134	73	>	>	XX
10_1101-2021_02_13_429885	134	74	60	60	CD
10_1101-2021_02_13_429885	134	75	%	%	NN
10_1101-2021_02_13_429885	134	76	-	-	,
10_1101-2021_02_13_429885	134	77	so	so	IN
10_1101-2021_02_13_429885	134	78	the	the	DT
10_1101-2021_02_13_429885	134	79	signal	signal	NN
10_1101-2021_02_13_429885	134	80	is	be	VBZ
10_1101-2021_02_13_429885	134	81	suitable	suitable	JJ
10_1101-2021_02_13_429885	134	82	for	for	IN
10_1101-2021_02_13_429885	134	83	peak	peak	NN
10_1101-2021_02_13_429885	134	84	detection	detection	NN
10_1101-2021_02_13_429885	134	85	.	.	.
10_1101-2021_02_13_429885	135	1	On	on	IN
10_1101-2021_02_13_429885	135	2	a	a	DT
10_1101-2021_02_13_429885	135	3	standard	standard	JJ
10_1101-2021_02_13_429885	135	4	cluster	cluster	NN
10_1101-2021_02_13_429885	135	5	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	135	6	ran	run	VBD
10_1101-2021_02_13_429885	135	7	in	in	IN
10_1101-2021_02_13_429885	135	8	less	less	JJR
10_1101-2021_02_13_429885	135	9	than	than	IN
10_1101-2021_02_13_429885	135	10	1	1	CD
10_1101-2021_02_13_429885	135	11	hour	hour	NN
10_1101-2021_02_13_429885	135	12	for	for	IN
10_1101-2021_02_13_429885	135	13	these	these	DT
10_1101-2021_02_13_429885	135	14	samples	sample	NNS
10_1101-2021_02_13_429885	135	15	;	;	:
10_1101-2021_02_13_429885	135	16	notably	notably	RB
10_1101-2021_02_13_429885	135	17	the	the	DT
10_1101-2021_02_13_429885	135	18	1	1	CD
10_1101-2021_02_13_429885	135	19	Technically	technically	RB
10_1101-2021_02_13_429885	135	20	the	the	DT
10_1101-2021_02_13_429885	135	21	default	default	JJ
10_1101-2021_02_13_429885	135	22	Sequenza	Sequenza	NNP
10_1101-2021_02_13_429885	135	23	values	value	NNS
10_1101-2021_02_13_429885	135	24	for	for	IN
10_1101-2021_02_13_429885	135	25	ploidy	ploidy	NN
10_1101-2021_02_13_429885	135	26	reach	reach	NN
10_1101-2021_02_13_429885	135	27	maximum	maximum	NN
10_1101-2021_02_13_429885	135	28	at	at	IN
10_1101-2021_02_13_429885	135	29	7	7	CD
10_1101-2021_02_13_429885	135	30	;	;	:
10_1101-2021_02_13_429885	135	31	being	be	VBG
10_1101-2021_02_13_429885	135	32	unrealistic	unrealistic	JJ
10_1101-2021_02_13_429885	135	33	for	for	IN
10_1101-2021_02_13_429885	135	34	our	-PRON-	PRP$
10_1101-2021_02_13_429885	135	35	cases	case	NNS
10_1101-2021_02_13_429885	135	36	we	-PRON-	PRP
10_1101-2021_02_13_429885	135	37	limited	limit	VBD
10_1101-2021_02_13_429885	135	38	the	the	DT
10_1101-2021_02_13_429885	135	39	maximum	maximum	JJ
10_1101-2021_02_13_429885	135	40	ploidy	ploidy	NN
10_1101-2021_02_13_429885	135	41	to	to	TO
10_1101-2021_02_13_429885	135	42	be	be	VB
10_1101-2021_02_13_429885	135	43	5	5	CD
10_1101-2021_02_13_429885	135	44	.	.	.
10_1101-2021_02_13_429885	136	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	136	2	-	-	:
10_1101-2021_02_13_429885	136	3	BY	by	IN
10_1101-2021_02_13_429885	136	4	-	-	HYPH
10_1101-2021_02_13_429885	136	5	NC	NC	NNP
10_1101-2021_02_13_429885	136	6	-	-	HYPH
10_1101-2021_02_13_429885	136	7	ND	ND	NNP
10_1101-2021_02_13_429885	136	8	4.0	4.0	CD
10_1101-2021_02_13_429885	136	9	International	International	NNP
10_1101-2021_02_13_429885	136	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	136	11	under	under	IN
10_1101-2021_02_13_429885	136	12	a	a	DT
10_1101-2021_02_13_429885	136	13	(	(	-LRB-
10_1101-2021_02_13_429885	136	14	which	which	WDT
10_1101-2021_02_13_429885	136	15	was	be	VBD
10_1101-2021_02_13_429885	136	16	not	not	RB
10_1101-2021_02_13_429885	136	17	certified	certify	VBN
10_1101-2021_02_13_429885	136	18	by	by	IN
10_1101-2021_02_13_429885	136	19	peer	peer	NN
10_1101-2021_02_13_429885	136	20	review	review	NN
10_1101-2021_02_13_429885	136	21	)	)	-RRB-
10_1101-2021_02_13_429885	136	22	is	be	VBZ
10_1101-2021_02_13_429885	136	23	the	the	DT
10_1101-2021_02_13_429885	136	24	author	author	NN
10_1101-2021_02_13_429885	136	25	/	/	SYM
10_1101-2021_02_13_429885	136	26	funder	funder	NN
10_1101-2021_02_13_429885	136	27	,	,	,
10_1101-2021_02_13_429885	136	28	who	who	WP
10_1101-2021_02_13_429885	136	29	has	have	VBZ
10_1101-2021_02_13_429885	136	30	granted	grant	VBN
10_1101-2021_02_13_429885	136	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	136	32	a	a	DT
10_1101-2021_02_13_429885	136	33	license	license	NN
10_1101-2021_02_13_429885	136	34	to	to	TO
10_1101-2021_02_13_429885	136	35	display	display	VB
10_1101-2021_02_13_429885	136	36	the	the	DT
10_1101-2021_02_13_429885	136	37	preprint	preprint	NN
10_1101-2021_02_13_429885	136	38	in	in	IN
10_1101-2021_02_13_429885	136	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	136	40	.	.	.
10_1101-2021_02_13_429885	137	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	137	2	is	be	VBZ
10_1101-2021_02_13_429885	137	3	made	make	VBN
10_1101-2021_02_13_429885	137	4	The	the	DT
10_1101-2021_02_13_429885	137	5	copyright	copyright	NN
10_1101-2021_02_13_429885	137	6	holder	holder	NN
10_1101-2021_02_13_429885	137	7	for	for	IN
10_1101-2021_02_13_429885	137	8	this	this	DT
10_1101-2021_02_13_429885	137	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	137	10	version	version	NN
10_1101-2021_02_13_429885	137	11	posted	post	VBD
10_1101-2021_02_13_429885	137	12	February	February	NNP
10_1101-2021_02_13_429885	137	13	13	13	CD
10_1101-2021_02_13_429885	137	14	,	,	,
10_1101-2021_02_13_429885	137	15	2021	2021	CD
10_1101-2021_02_13_429885	137	16	.	.	.
10_1101-2021_02_13_429885	137	17	;	;	:
10_1101-2021_02_13_429885	137	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	137	19	:	:	:
10_1101-2021_02_13_429885	137	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	137	21	preprint	preprint	NN
10_1101-2021_02_13_429885	137	22	https://paperpile.com/c/rqVmzs/IC0y	https://paperpile.com/c/rqVmzs/IC0y	NNP
10_1101-2021_02_13_429885	137	23	https://paperpile.com/c/rqVmzs/IC0y	https://paperpile.com/c/rqVmzs/IC0y	NNP
10_1101-2021_02_13_429885	137	24	https://paperpile.com/c/rqVmzs/IC0y	https://paperpile.com/c/rqVmzs/IC0y	NNP
10_1101-2021_02_13_429885	137	25	https://paperpile.com/c/rqVmzs/CxXa	https://paperpile.com/c/rqVmzs/CxXa	NNP
10_1101-2021_02_13_429885	137	26	https://paperpile.com/c/rqVmzs/chqB	https://paperpile.com/c/rqVmzs/chqB	NNP
10_1101-2021_02_13_429885	137	27	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	137	28	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	137	29	Househam	Househam	NNP
10_1101-2021_02_13_429885	137	30	et	et	FW
10_1101-2021_02_13_429885	137	31	al	al	NNP
10_1101-2021_02_13_429885	137	32	.	.	.
10_1101-2021_02_13_429885	138	1	A	a	DT
10_1101-2021_02_13_429885	138	2	fully	fully	RB
10_1101-2021_02_13_429885	138	3	automated	automate	VBN
10_1101-2021_02_13_429885	138	4	approach	approach	NN
10_1101-2021_02_13_429885	138	5	for	for	IN
10_1101-2021_02_13_429885	138	6	quality	quality	NN
10_1101-2021_02_13_429885	138	7	control	control	NN
10_1101-2021_02_13_429885	138	8	of	of	IN
10_1101-2021_02_13_429885	138	9	cancer	cancer	NN
10_1101-2021_02_13_429885	138	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	138	11	in	in	IN
10_1101-2021_02_13_429885	138	12	the	the	DT
10_1101-2021_02_13_429885	138	13	era	era	NN
10_1101-2021_02_13_429885	138	14	of	of	IN
10_1101-2021_02_13_429885	138	15	high	high	JJ
10_1101-2021_02_13_429885	138	16	-	-	HYPH
10_1101-2021_02_13_429885	138	17	resolution	resolution	NN
10_1101-2021_02_13_429885	138	18	whole	whole	JJ
10_1101-2021_02_13_429885	138	19	genome	genome	JJ
10_1101-2021_02_13_429885	138	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	138	21	.	.	.
10_1101-2021_02_13_429885	139	1	completion	completion	NN
10_1101-2021_02_13_429885	139	2	time	time	NN
10_1101-2021_02_13_429885	139	3	(	(	-LRB-
10_1101-2021_02_13_429885	139	4	per	per	FW
10_1101-2021_02_13_429885	139	5	sample	sample	NN
10_1101-2021_02_13_429885	139	6	)	)	-RRB-
10_1101-2021_02_13_429885	139	7	on	on	IN
10_1101-2021_02_13_429885	139	8	a	a	DT
10_1101-2021_02_13_429885	139	9	laptop	laptop	NN
10_1101-2021_02_13_429885	139	10	is	be	VBZ
10_1101-2021_02_13_429885	139	11	less	less	JJR
10_1101-2021_02_13_429885	139	12	than	than	IN
10_1101-2021_02_13_429885	139	13	1	1	CD
10_1101-2021_02_13_429885	139	14	minute	minute	NN
10_1101-2021_02_13_429885	139	15	,	,	,
10_1101-2021_02_13_429885	139	16	meaning	mean	VBG
10_1101-2021_02_13_429885	139	17	that	that	IN
10_1101-2021_02_13_429885	139	18	preliminary	preliminary	JJ
10_1101-2021_02_13_429885	139	19	analysis	analysis	NN
10_1101-2021_02_13_429885	139	20	can	can	MD
10_1101-2021_02_13_429885	139	21	be	be	VB
10_1101-2021_02_13_429885	139	22	carried	carry	VBN
10_1101-2021_02_13_429885	139	23	out	out	RP
10_1101-2021_02_13_429885	139	24	very	very	RB
10_1101-2021_02_13_429885	139	25	quickly	quickly	RB
10_1101-2021_02_13_429885	139	26	and	and	CC
10_1101-2021_02_13_429885	139	27	without	without	IN
10_1101-2021_02_13_429885	139	28	large	large	JJ
10_1101-2021_02_13_429885	139	29	computing	computing	NN
10_1101-2021_02_13_429885	139	30	infrastructures	infrastructure	NNS
10_1101-2021_02_13_429885	139	31	.	.	.
10_1101-2021_02_13_429885	140	1	The	the	DT
10_1101-2021_02_13_429885	140	2	calls	call	NNS
10_1101-2021_02_13_429885	140	3	in	in	IN
10_1101-2021_02_13_429885	140	4	PCAWG	PCAWG	NNP
10_1101-2021_02_13_429885	140	5	were	be	VBD
10_1101-2021_02_13_429885	140	6	obtained	obtain	VBN
10_1101-2021_02_13_429885	140	7	by	by	IN
10_1101-2021_02_13_429885	140	8	consensus	consensus	NN
10_1101-2021_02_13_429885	140	9	with	with	IN
10_1101-2021_02_13_429885	140	10	multiple	multiple	JJ
10_1101-2021_02_13_429885	140	11	bioinformatics	bioinformatic	NNS
10_1101-2021_02_13_429885	140	12	tools	tool	NNS
10_1101-2021_02_13_429885	140	13	,	,	,
10_1101-2021_02_13_429885	140	14	and	and	CC
10_1101-2021_02_13_429885	140	15	for	for	IN
10_1101-2021_02_13_429885	140	16	this	this	DT
10_1101-2021_02_13_429885	140	17	reason	reason	NN
10_1101-2021_02_13_429885	140	18	we	-PRON-	PRP
10_1101-2021_02_13_429885	140	19	expected	expect	VBD
10_1101-2021_02_13_429885	140	20	them	-PRON-	PRP
10_1101-2021_02_13_429885	140	21	to	to	TO
10_1101-2021_02_13_429885	140	22	be	be	VB
10_1101-2021_02_13_429885	140	23	reliable	reliable	JJ
10_1101-2021_02_13_429885	140	24	.	.	.
10_1101-2021_02_13_429885	141	1	Manual	manual	JJ
10_1101-2021_02_13_429885	141	2	inspections	inspection	NNS
10_1101-2021_02_13_429885	141	3	of	of	IN
10_1101-2021_02_13_429885	141	4	some	some	DT
10_1101-2021_02_13_429885	141	5	patient	patient	JJ
10_1101-2021_02_13_429885	141	6	data	datum	NNS
10_1101-2021_02_13_429885	141	7	showed	show	VBD
10_1101-2021_02_13_429885	141	8	indeed	indeed	RB
10_1101-2021_02_13_429885	141	9	many	many	JJ
10_1101-2021_02_13_429885	141	10	high	high	JJ
10_1101-2021_02_13_429885	141	11	-	-	HYPH
10_1101-2021_02_13_429885	141	12	quality	quality	NN
10_1101-2021_02_13_429885	141	13	calls	call	NNS
10_1101-2021_02_13_429885	141	14	,	,	,
10_1101-2021_02_13_429885	141	15	but	but	CC
10_1101-2021_02_13_429885	141	16	also	also	RB
10_1101-2021_02_13_429885	141	17	highlighted	highlight	VBD
10_1101-2021_02_13_429885	141	18	a	a	DT
10_1101-2021_02_13_429885	141	19	variety	variety	NN
10_1101-2021_02_13_429885	141	20	of	of	IN
10_1101-2021_02_13_429885	141	21	interesting	interesting	JJ
10_1101-2021_02_13_429885	141	22	cases	case	NNS
10_1101-2021_02_13_429885	141	23	.	.	.
10_1101-2021_02_13_429885	142	1	For	for	IN
10_1101-2021_02_13_429885	142	2	instance	instance	NN
10_1101-2021_02_13_429885	142	3	,	,	,
10_1101-2021_02_13_429885	142	4	tumours	tumour	NNS
10_1101-2021_02_13_429885	142	5	with	with	IN
10_1101-2021_02_13_429885	142	6	extremely	extremely	RB
10_1101-2021_02_13_429885	142	7	low	low	JJ
10_1101-2021_02_13_429885	142	8	mutational	mutational	JJ
10_1101-2021_02_13_429885	142	9	burden	burden	NN
10_1101-2021_02_13_429885	142	10	but	but	CC
10_1101-2021_02_13_429885	142	11	high	high	JJ
10_1101-2021_02_13_429885	142	12	quality	quality	NN
10_1101-2021_02_13_429885	142	13	calls	call	NNS
10_1101-2021_02_13_429885	142	14	still	still	RB
10_1101-2021_02_13_429885	142	15	yielded	yield	VBD
10_1101-2021_02_13_429885	142	16	a	a	DT
10_1101-2021_02_13_429885	142	17	useful	useful	JJ
10_1101-2021_02_13_429885	142	18	report	report	NN
10_1101-2021_02_13_429885	142	19	,	,	,
10_1101-2021_02_13_429885	142	20	suggesting	suggest	VBG
10_1101-2021_02_13_429885	142	21	that	that	IN
10_1101-2021_02_13_429885	142	22	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	142	23	can	can	MD
10_1101-2021_02_13_429885	142	24	work	work	VB
10_1101-2021_02_13_429885	142	25	also	also	RB
10_1101-2021_02_13_429885	142	26	with	with	IN
10_1101-2021_02_13_429885	142	27	mutational	mutational	JJ
10_1101-2021_02_13_429885	142	28	burden	burden	NN
10_1101-2021_02_13_429885	142	29	from	from	IN
10_1101-2021_02_13_429885	142	30	whole	whole	JJ
10_1101-2021_02_13_429885	142	31	-	-	HYPH
10_1101-2021_02_13_429885	142	32	exome	exome	NN
10_1101-2021_02_13_429885	142	33	sequencing	sequencing	NN
10_1101-2021_02_13_429885	142	34	(	(	-LRB-
10_1101-2021_02_13_429885	142	35	​Supplementary	​supplementary	JJ
10_1101-2021_02_13_429885	142	36	Figure	figure	NN
10_1101-2021_02_13_429885	142	37	S1	s1	NN
10_1101-2021_02_13_429885	142	38	​	​	JJ
10_1101-2021_02_13_429885	142	39	)	)	-RRB-
10_1101-2021_02_13_429885	142	40	.	.	.
10_1101-2021_02_13_429885	143	1	For	for	IN
10_1101-2021_02_13_429885	143	2	other	other	JJ
10_1101-2021_02_13_429885	143	3	tumours	tumour	NNS
10_1101-2021_02_13_429885	143	4	,	,	,
10_1101-2021_02_13_429885	143	5	we	-PRON-	PRP
10_1101-2021_02_13_429885	143	6	found	find	VBD
10_1101-2021_02_13_429885	143	7	high	high	JJ
10_1101-2021_02_13_429885	143	8	purity	purity	NN
10_1101-2021_02_13_429885	143	9	levels	level	NNS
10_1101-2021_02_13_429885	143	10	>	>	XX
10_1101-2021_02_13_429885	143	11	90	90	CD
10_1101-2021_02_13_429885	143	12	%	%	NN
10_1101-2021_02_13_429885	143	13	,	,	,
10_1101-2021_02_13_429885	143	14	which	which	WDT
10_1101-2021_02_13_429885	143	15	are	be	VBP
10_1101-2021_02_13_429885	143	16	probably	probably	RB
10_1101-2021_02_13_429885	143	17	overestimated	overestimate	VBN
10_1101-2021_02_13_429885	143	18	(	(	-LRB-
10_1101-2021_02_13_429885	143	19	​Supplementary	​supplementary	JJ
10_1101-2021_02_13_429885	143	20	Figure	figure	NN
10_1101-2021_02_13_429885	143	21	S11	S11	NNP
10_1101-2021_02_13_429885	143	22	​	​	NNP
10_1101-2021_02_13_429885	143	23	)	)	-RRB-
10_1101-2021_02_13_429885	143	24	compared	compare	VBN
10_1101-2021_02_13_429885	143	25	to	to	IN
10_1101-2021_02_13_429885	143	26	others	other	NNS
10_1101-2021_02_13_429885	143	27	where	where	WRB
10_1101-2021_02_13_429885	143	28	purity	purity	NN
10_1101-2021_02_13_429885	143	29	is	be	VBZ
10_1101-2021_02_13_429885	143	30	genuinely	genuinely	RB
10_1101-2021_02_13_429885	143	31	very	very	RB
10_1101-2021_02_13_429885	143	32	high	high	JJ
10_1101-2021_02_13_429885	143	33	(	(	-LRB-
10_1101-2021_02_13_429885	143	34	​Supplementary	​supplementary	JJ
10_1101-2021_02_13_429885	143	35	Figure	figure	NN
10_1101-2021_02_13_429885	143	36	S12	S12	NNP
10_1101-2021_02_13_429885	143	37	​	​	NNP
10_1101-2021_02_13_429885	143	38	)	)	-RRB-
10_1101-2021_02_13_429885	143	39	.	.	.
10_1101-2021_02_13_429885	144	1	Overall	overall	RB
10_1101-2021_02_13_429885	144	2	,	,	,
10_1101-2021_02_13_429885	144	3	the	the	DT
10_1101-2021_02_13_429885	144	4	scores	score	NNS
10_1101-2021_02_13_429885	144	5	from	from	IN
10_1101-2021_02_13_429885	144	6	peak	peak	NN
10_1101-2021_02_13_429885	144	7	detection	detection	NN
10_1101-2021_02_13_429885	144	8	are	be	VBP
10_1101-2021_02_13_429885	144	9	reliable	reliable	JJ
10_1101-2021_02_13_429885	144	10	for	for	IN
10_1101-2021_02_13_429885	144	11	the	the	DT
10_1101-2021_02_13_429885	144	12	majority	majority	NN
10_1101-2021_02_13_429885	144	13	of	of	IN
10_1101-2021_02_13_429885	144	14	the	the	DT
10_1101-2021_02_13_429885	144	15	analysed	analyse	VBN
10_1101-2021_02_13_429885	144	16	samples	sample	NNS
10_1101-2021_02_13_429885	144	17	(	(	-LRB-
10_1101-2021_02_13_429885	144	18	​Figure	​figure	NN
10_1101-2021_02_13_429885	144	19	5a	5a	CD
10_1101-2021_02_13_429885	144	20	​	​	JJ
10_1101-2021_02_13_429885	144	21	)	)	-RRB-
10_1101-2021_02_13_429885	144	22	-	-	:
10_1101-2021_02_13_429885	144	23	the	the	DT
10_1101-2021_02_13_429885	144	24	diploid	diploid	NNP
10_1101-2021_02_13_429885	144	25	85	85	CD
10_1101-2021_02_13_429885	144	26	%	%	NN
10_1101-2021_02_13_429885	144	27	purity	purity	NN
10_1101-2021_02_13_429885	144	28	tumour	tumour	NN
10_1101-2021_02_13_429885	144	29	in	in	IN
10_1101-2021_02_13_429885	144	30	​Figures	​figure	NNS
10_1101-2021_02_13_429885	144	31	2	2	CD
10_1101-2021_02_13_429885	144	32	​and	​and	CC
10_1101-2021_02_13_429885	144	33	3	3	CD
10_1101-2021_02_13_429885	144	34	is	be	VBZ
10_1101-2021_02_13_429885	144	35	taken	take	VBN
10_1101-2021_02_13_429885	144	36	from	from	IN
10_1101-2021_02_13_429885	144	37	this	this	DT
10_1101-2021_02_13_429885	144	38	list	list	NN
10_1101-2021_02_13_429885	144	39	-	-	:
10_1101-2021_02_13_429885	144	40	with	with	IN
10_1101-2021_02_13_429885	144	41	only	only	RB
10_1101-2021_02_13_429885	144	42	a	a	DT
10_1101-2021_02_13_429885	144	43	few	few	JJ
10_1101-2021_02_13_429885	144	44	cases	case	NNS
10_1101-2021_02_13_429885	144	45	requiring	require	VBG
10_1101-2021_02_13_429885	144	46	further	further	JJ
10_1101-2021_02_13_429885	144	47	checks	check	NNS
10_1101-2021_02_13_429885	144	48	(	(	-LRB-
10_1101-2021_02_13_429885	144	49	​Figure	​figure	NN
10_1101-2021_02_13_429885	144	50	5b	5b	NN
10_1101-2021_02_13_429885	144	51	​	​	JJ
10_1101-2021_02_13_429885	144	52	)	)	-RRB-
10_1101-2021_02_13_429885	144	53	.	.	.
10_1101-2021_02_13_429885	145	1	The	the	DT
10_1101-2021_02_13_429885	145	2	peak	peak	NN
10_1101-2021_02_13_429885	145	3	detection	detection	NN
10_1101-2021_02_13_429885	145	4	by	by	IN
10_1101-2021_02_13_429885	145	5	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	145	6	therefore	therefore	RB
10_1101-2021_02_13_429885	145	7	confirms	confirm	VBZ
10_1101-2021_02_13_429885	145	8	the	the	DT
10_1101-2021_02_13_429885	145	9	calls	call	NNS
10_1101-2021_02_13_429885	145	10	reliability	reliability	NN
10_1101-2021_02_13_429885	145	11	in	in	IN
10_1101-2021_02_13_429885	145	12	terms	term	NNS
10_1101-2021_02_13_429885	145	13	of	of	IN
10_1101-2021_02_13_429885	145	14	breakpoints	breakpoint	NNS
10_1101-2021_02_13_429885	145	15	,	,	,
10_1101-2021_02_13_429885	145	16	segments	segment	VBZ
10_1101-2021_02_13_429885	145	17	ploidy	ploidy	NN
10_1101-2021_02_13_429885	145	18	and	and	CC
10_1101-2021_02_13_429885	145	19	tumour	tumour	NN
10_1101-2021_02_13_429885	145	20	purity	purity	NN
10_1101-2021_02_13_429885	145	21	.	.	.
10_1101-2021_02_13_429885	146	1	CCF	ccf	NN
10_1101-2021_02_13_429885	146	2	computations	computation	NNS
10_1101-2021_02_13_429885	146	3	showed	show	VBD
10_1101-2021_02_13_429885	146	4	a	a	DT
10_1101-2021_02_13_429885	146	5	higher	high	JJR
10_1101-2021_02_13_429885	146	6	rate	rate	NN
10_1101-2021_02_13_429885	146	7	of	of	IN
10_1101-2021_02_13_429885	146	8	failures	failure	NNS
10_1101-2021_02_13_429885	146	9	with	with	IN
10_1101-2021_02_13_429885	146	10	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	146	11	analysis	analysis	NN
10_1101-2021_02_13_429885	146	12	(	(	-LRB-
10_1101-2021_02_13_429885	146	13	​Figure	​figure	NN
10_1101-2021_02_13_429885	146	14	5a	5a	CD
10_1101-2021_02_13_429885	146	15	​	​	JJ
10_1101-2021_02_13_429885	146	16	)	)	-RRB-
10_1101-2021_02_13_429885	146	17	.	.	.
10_1101-2021_02_13_429885	147	1	This	this	DT
10_1101-2021_02_13_429885	147	2	is	be	VBZ
10_1101-2021_02_13_429885	147	3	inevitably	inevitably	RB
10_1101-2021_02_13_429885	147	4	due	due	JJ
10_1101-2021_02_13_429885	147	5	to	to	IN
10_1101-2021_02_13_429885	147	6	the	the	DT
10_1101-2021_02_13_429885	147	7	lack	lack	NN
10_1101-2021_02_13_429885	147	8	of	of	IN
10_1101-2021_02_13_429885	147	9	signal	signal	JJ
10_1101-2021_02_13_429885	147	10	separability	separability	NN
10_1101-2021_02_13_429885	147	11	stemming	stem	VBG
10_1101-2021_02_13_429885	147	12	from	from	IN
10_1101-2021_02_13_429885	147	13	low	low	JJ
10_1101-2021_02_13_429885	147	14	coverage	coverage	NN
10_1101-2021_02_13_429885	147	15	of	of	IN
10_1101-2021_02_13_429885	147	16	these	these	DT
10_1101-2021_02_13_429885	147	17	samples	sample	NNS
10_1101-2021_02_13_429885	147	18	,	,	,
10_1101-2021_02_13_429885	147	19	even	even	RB
10_1101-2021_02_13_429885	147	20	for	for	IN
10_1101-2021_02_13_429885	147	21	high	high	JJ
10_1101-2021_02_13_429885	147	22	-	-	HYPH
10_1101-2021_02_13_429885	147	23	quality	quality	NN
10_1101-2021_02_13_429885	147	24	genomes	genome	NNS
10_1101-2021_02_13_429885	147	25	.	.	.
10_1101-2021_02_13_429885	148	1	Therefore	therefore	RB
10_1101-2021_02_13_429885	148	2	while	while	IN
10_1101-2021_02_13_429885	148	3	peaks	peak	NNS
10_1101-2021_02_13_429885	148	4	could	could	MD
10_1101-2021_02_13_429885	148	5	be	be	VB
10_1101-2021_02_13_429885	148	6	determined	determine	VBN
10_1101-2021_02_13_429885	148	7	for	for	IN
10_1101-2021_02_13_429885	148	8	these	these	DT
10_1101-2021_02_13_429885	148	9	data	datum	NNS
10_1101-2021_02_13_429885	148	10	,	,	,
10_1101-2021_02_13_429885	148	11	mutation	mutation	NN
10_1101-2021_02_13_429885	148	12	multiplicity	multiplicity	NN
10_1101-2021_02_13_429885	148	13	assessment	assessment	NN
10_1101-2021_02_13_429885	148	14	would	would	MD
10_1101-2021_02_13_429885	148	15	have	have	VB
10_1101-2021_02_13_429885	148	16	required	require	VBN
10_1101-2021_02_13_429885	148	17	higher	high	JJR
10_1101-2021_02_13_429885	148	18	coverage	coverage	NN
10_1101-2021_02_13_429885	148	19	than	than	IN
10_1101-2021_02_13_429885	148	20	what	what	WP
10_1101-2021_02_13_429885	148	21	was	be	VBD
10_1101-2021_02_13_429885	148	22	found	find	VBN
10_1101-2021_02_13_429885	148	23	available	available	JJ
10_1101-2021_02_13_429885	148	24	.	.	.
10_1101-2021_02_13_429885	149	1	In	in	IN
10_1101-2021_02_13_429885	149	2	summary	summary	NN
10_1101-2021_02_13_429885	149	3	,	,	,
10_1101-2021_02_13_429885	149	4	from	from	IN
10_1101-2021_02_13_429885	149	5	these	these	DT
10_1101-2021_02_13_429885	149	6	analyses	analysis	NNS
10_1101-2021_02_13_429885	149	7	we	-PRON-	PRP
10_1101-2021_02_13_429885	149	8	revealed	reveal	VBD
10_1101-2021_02_13_429885	149	9	that	that	IN
10_1101-2021_02_13_429885	149	10	the	the	DT
10_1101-2021_02_13_429885	149	11	problem	problem	NN
10_1101-2021_02_13_429885	149	12	of	of	IN
10_1101-2021_02_13_429885	149	13	validating	validate	VBG
10_1101-2021_02_13_429885	149	14	CNA	CNA	NNP
10_1101-2021_02_13_429885	149	15	calls	call	NNS
10_1101-2021_02_13_429885	149	16	,	,	,
10_1101-2021_02_13_429885	149	17	compared	compare	VBN
10_1101-2021_02_13_429885	149	18	to	to	IN
10_1101-2021_02_13_429885	149	19	determining	determine	VBG
10_1101-2021_02_13_429885	149	20	CCF	ccf	NN
10_1101-2021_02_13_429885	149	21	estimates	estimate	NNS
10_1101-2021_02_13_429885	149	22	,	,	,
10_1101-2021_02_13_429885	149	23	can	can	MD
10_1101-2021_02_13_429885	149	24	be	be	VB
10_1101-2021_02_13_429885	149	25	approached	approach	VBN
10_1101-2021_02_13_429885	149	26	with	with	IN
10_1101-2021_02_13_429885	149	27	lower	low	JJR
10_1101-2021_02_13_429885	149	28	coverage	coverage	NN
10_1101-2021_02_13_429885	149	29	and	and	CC
10_1101-2021_02_13_429885	149	30	purity	purity	NN
10_1101-2021_02_13_429885	149	31	values	value	NNS
10_1101-2021_02_13_429885	149	32	using	use	VBG
10_1101-2021_02_13_429885	149	33	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	149	34	.	.	.
10_1101-2021_02_13_429885	150	1	Discussion	discussion	NN
10_1101-2021_02_13_429885	150	2	WGS	WGS	NNP
10_1101-2021_02_13_429885	150	3	is	be	VBZ
10_1101-2021_02_13_429885	150	4	a	a	DT
10_1101-2021_02_13_429885	150	5	powerful	powerful	JJ
10_1101-2021_02_13_429885	150	6	approach	approach	NN
10_1101-2021_02_13_429885	150	7	to	to	TO
10_1101-2021_02_13_429885	150	8	detect	detect	VB
10_1101-2021_02_13_429885	150	9	extensive	extensive	JJ
10_1101-2021_02_13_429885	150	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	150	11	that	that	WDT
10_1101-2021_02_13_429885	150	12	drive	drive	VBP
10_1101-2021_02_13_429885	150	13	human	human	JJ
10_1101-2021_02_13_429885	150	14	cancers	cancer	NNS
10_1101-2021_02_13_429885	150	15	.	.	.
10_1101-2021_02_13_429885	151	1	Many	many	JJ
10_1101-2021_02_13_429885	151	2	large	large	JJ
10_1101-2021_02_13_429885	151	3	-	-	HYPH
10_1101-2021_02_13_429885	151	4	scale	scale	NN
10_1101-2021_02_13_429885	151	5	initiatives	initiative	NNS
10_1101-2021_02_13_429885	151	6	such	such	JJ
10_1101-2021_02_13_429885	151	7	as	as	IN
10_1101-2021_02_13_429885	151	8	PCAWG	PCAWG	NNP
10_1101-2021_02_13_429885	151	9	​(Campbell	​(Campbell	NNP
10_1101-2021_02_13_429885	151	10	et	et	FW
10_1101-2021_02_13_429885	151	11	al	al	NNP
10_1101-2021_02_13_429885	151	12	.	.	.
10_1101-2021_02_13_429885	152	1	2020)​	2020)​	CD
10_1101-2021_02_13_429885	152	2	,	,	,
10_1101-2021_02_13_429885	152	3	the	the	DT
10_1101-2021_02_13_429885	152	4	Hartwig	Hartwig	NNP
10_1101-2021_02_13_429885	152	5	Medical	Medical	NNP
10_1101-2021_02_13_429885	152	6	Foundation	Foundation	NNP
10_1101-2021_02_13_429885	152	7	​(Priestley	​(Priestley	NNP
10_1101-2021_02_13_429885	152	8	et	et	NNP
10_1101-2021_02_13_429885	152	9	al	al	NNP
10_1101-2021_02_13_429885	152	10	.	.	.
10_1101-2021_02_13_429885	153	1	2019	2019	CD
10_1101-2021_02_13_429885	153	2	)	)	-RRB-
10_1101-2021_02_13_429885	153	3	and	and	CC
10_1101-2021_02_13_429885	153	4	Genomics	Genomics	NNP
10_1101-2021_02_13_429885	153	5	England	England	NNP
10_1101-2021_02_13_429885	153	6	​(Turnbull	​(Turnbull	NNP
10_1101-2021_02_13_429885	153	7	et	et	NNP
10_1101-2021_02_13_429885	153	8	al	al	NNP
10_1101-2021_02_13_429885	153	9	.	.	.
10_1101-2021_02_13_429885	154	1	2018	2018	CD
10_1101-2021_02_13_429885	154	2	)	)	-RRB-
10_1101-2021_02_13_429885	154	3	have	have	VBP
10_1101-2021_02_13_429885	154	4	already	already	RB
10_1101-2021_02_13_429885	154	5	generated	generate	VBN
10_1101-2021_02_13_429885	154	6	WGS	WGS	NNP
10_1101-2021_02_13_429885	154	7	data	datum	NNS
10_1101-2021_02_13_429885	154	8	for	for	IN
10_1101-2021_02_13_429885	154	9	thousands	thousand	NNS
10_1101-2021_02_13_429885	154	10	of	of	IN
10_1101-2021_02_13_429885	154	11	cancer	cancer	NN
10_1101-2021_02_13_429885	154	12	patients	patient	NNS
10_1101-2021_02_13_429885	154	13	,	,	,
10_1101-2021_02_13_429885	154	14	with	with	IN
10_1101-2021_02_13_429885	154	15	many	many	JJ
10_1101-2021_02_13_429885	154	16	cancer	cancer	NN
10_1101-2021_02_13_429885	154	17	institutes	institute	NNS
10_1101-2021_02_13_429885	154	18	converging	converge	VBG
10_1101-2021_02_13_429885	154	19	towards	towards	IN
10_1101-2021_02_13_429885	154	20	these	these	DT
10_1101-2021_02_13_429885	154	21	efforts	effort	NNS
10_1101-2021_02_13_429885	154	22	.	.	.
10_1101-2021_02_13_429885	155	1	Calling	call	VBG
10_1101-2021_02_13_429885	155	2	mutations	mutation	NNS
10_1101-2021_02_13_429885	155	3	from	from	IN
10_1101-2021_02_13_429885	155	4	WGS	WGS	NNP
10_1101-2021_02_13_429885	155	5	data	datum	NNS
10_1101-2021_02_13_429885	155	6	requires	require	VBZ
10_1101-2021_02_13_429885	155	7	complex	complex	JJ
10_1101-2021_02_13_429885	155	8	bioinformatics	bioinformatic	NNS
10_1101-2021_02_13_429885	155	9	pipelines	pipeline	NNS
10_1101-2021_02_13_429885	155	10	​(Barnell	​(Barnell	NNP
10_1101-2021_02_13_429885	155	11	et	et	FW
10_1101-2021_02_13_429885	155	12	al	al	NNP
10_1101-2021_02_13_429885	155	13	.	.	.
10_1101-2021_02_13_429885	156	1	2019	2019	CD
10_1101-2021_02_13_429885	156	2	;	;	:
10_1101-2021_02_13_429885	156	3	Cmero	Cmero	NNP
10_1101-2021_02_13_429885	156	4	et	et	NNP
10_1101-2021_02_13_429885	156	5	al	al	NNP
10_1101-2021_02_13_429885	156	6	.	.	.
10_1101-2021_02_13_429885	157	1	2020	2020	CD
10_1101-2021_02_13_429885	157	2	;	;	:
10_1101-2021_02_13_429885	157	3	Li	Li	NNP
10_1101-2021_02_13_429885	157	4	et	et	NNP
10_1101-2021_02_13_429885	157	5	al	al	NNP
10_1101-2021_02_13_429885	157	6	.	.	.
10_1101-2021_02_13_429885	158	1	2020	2020	CD
10_1101-2021_02_13_429885	158	2	)	)	-RRB-
10_1101-2021_02_13_429885	158	3	and	and	CC
10_1101-2021_02_13_429885	158	4	any	any	DT
10_1101-2021_02_13_429885	158	5	downstream	downstream	JJ
10_1101-2021_02_13_429885	158	6	analysis	analysis	NN
10_1101-2021_02_13_429885	158	7	relies	rely	VBZ
10_1101-2021_02_13_429885	158	8	upon	upon	IN
10_1101-2021_02_13_429885	158	9	these	these	DT
10_1101-2021_02_13_429885	158	10	calls	call	NNS
10_1101-2021_02_13_429885	158	11	,	,	,
10_1101-2021_02_13_429885	158	12	putting	put	VBG
10_1101-2021_02_13_429885	158	13	the	the	DT
10_1101-2021_02_13_429885	158	14	quality	quality	NN
10_1101-2021_02_13_429885	158	15	of	of	IN
10_1101-2021_02_13_429885	158	16	the	the	DT
10_1101-2021_02_13_429885	158	17	generated	generate	VBN
10_1101-2021_02_13_429885	158	18	data	datum	NNS
10_1101-2021_02_13_429885	158	19	under	under	IN
10_1101-2021_02_13_429885	158	20	the	the	DT
10_1101-2021_02_13_429885	158	21	spotlight	spotlight	NN
10_1101-2021_02_13_429885	158	22	.	.	.
10_1101-2021_02_13_429885	159	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	159	2	-	-	:
10_1101-2021_02_13_429885	159	3	BY	by	IN
10_1101-2021_02_13_429885	159	4	-	-	HYPH
10_1101-2021_02_13_429885	159	5	NC	NC	NNP
10_1101-2021_02_13_429885	159	6	-	-	HYPH
10_1101-2021_02_13_429885	159	7	ND	ND	NNP
10_1101-2021_02_13_429885	159	8	4.0	4.0	CD
10_1101-2021_02_13_429885	159	9	International	International	NNP
10_1101-2021_02_13_429885	159	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	159	11	under	under	IN
10_1101-2021_02_13_429885	159	12	a	a	DT
10_1101-2021_02_13_429885	159	13	(	(	-LRB-
10_1101-2021_02_13_429885	159	14	which	which	WDT
10_1101-2021_02_13_429885	159	15	was	be	VBD
10_1101-2021_02_13_429885	159	16	not	not	RB
10_1101-2021_02_13_429885	159	17	certified	certify	VBN
10_1101-2021_02_13_429885	159	18	by	by	IN
10_1101-2021_02_13_429885	159	19	peer	peer	NN
10_1101-2021_02_13_429885	159	20	review	review	NN
10_1101-2021_02_13_429885	159	21	)	)	-RRB-
10_1101-2021_02_13_429885	159	22	is	be	VBZ
10_1101-2021_02_13_429885	159	23	the	the	DT
10_1101-2021_02_13_429885	159	24	author	author	NN
10_1101-2021_02_13_429885	159	25	/	/	SYM
10_1101-2021_02_13_429885	159	26	funder	funder	NN
10_1101-2021_02_13_429885	159	27	,	,	,
10_1101-2021_02_13_429885	159	28	who	who	WP
10_1101-2021_02_13_429885	159	29	has	have	VBZ
10_1101-2021_02_13_429885	159	30	granted	grant	VBN
10_1101-2021_02_13_429885	159	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	159	32	a	a	DT
10_1101-2021_02_13_429885	159	33	license	license	NN
10_1101-2021_02_13_429885	159	34	to	to	TO
10_1101-2021_02_13_429885	159	35	display	display	VB
10_1101-2021_02_13_429885	159	36	the	the	DT
10_1101-2021_02_13_429885	159	37	preprint	preprint	NN
10_1101-2021_02_13_429885	159	38	in	in	IN
10_1101-2021_02_13_429885	159	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	159	40	.	.	.
10_1101-2021_02_13_429885	160	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	160	2	is	be	VBZ
10_1101-2021_02_13_429885	160	3	made	make	VBN
10_1101-2021_02_13_429885	160	4	The	the	DT
10_1101-2021_02_13_429885	160	5	copyright	copyright	NN
10_1101-2021_02_13_429885	160	6	holder	holder	NN
10_1101-2021_02_13_429885	160	7	for	for	IN
10_1101-2021_02_13_429885	160	8	this	this	DT
10_1101-2021_02_13_429885	160	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	160	10	version	version	NN
10_1101-2021_02_13_429885	160	11	posted	post	VBD
10_1101-2021_02_13_429885	160	12	February	February	NNP
10_1101-2021_02_13_429885	160	13	13	13	CD
10_1101-2021_02_13_429885	160	14	,	,	,
10_1101-2021_02_13_429885	160	15	2021	2021	CD
10_1101-2021_02_13_429885	160	16	.	.	.
10_1101-2021_02_13_429885	160	17	;	;	:
10_1101-2021_02_13_429885	160	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	160	19	:	:	:
10_1101-2021_02_13_429885	160	20	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	160	21	preprint	preprint	NN
10_1101-2021_02_13_429885	160	22	https://paperpile.com/c/rqVmzs/CxXa	https://paperpile.com/c/rqvmzs/cxxa	SYM
10_1101-2021_02_13_429885	160	23	https://paperpile.com/c/rqVmzs/67up	https://paperpile.com/c/rqVmzs/67up	NNP
10_1101-2021_02_13_429885	160	24	https://paperpile.com/c/rqVmzs/mWfz	https://paperpile.com/c/rqVmzs/mWfz	NNP
10_1101-2021_02_13_429885	160	25	https://paperpile.com/c/rqVmzs/j5j7+ydMa+tMOu	https://paperpile.com/c/rqVmzs/j5j7+ydMa+tMOu	NNP
10_1101-2021_02_13_429885	160	26	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	NNP
10_1101-2021_02_13_429885	160	27	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	160	28	Househam	Househam	NNP
10_1101-2021_02_13_429885	160	29	et	et	FW
10_1101-2021_02_13_429885	160	30	al	al	NNP
10_1101-2021_02_13_429885	160	31	.	.	.
10_1101-2021_02_13_429885	161	1	A	a	DT
10_1101-2021_02_13_429885	161	2	fully	fully	RB
10_1101-2021_02_13_429885	161	3	automated	automate	VBN
10_1101-2021_02_13_429885	161	4	approach	approach	NN
10_1101-2021_02_13_429885	161	5	for	for	IN
10_1101-2021_02_13_429885	161	6	quality	quality	NN
10_1101-2021_02_13_429885	161	7	control	control	NN
10_1101-2021_02_13_429885	161	8	of	of	IN
10_1101-2021_02_13_429885	161	9	cancer	cancer	NN
10_1101-2021_02_13_429885	161	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	161	11	in	in	IN
10_1101-2021_02_13_429885	161	12	the	the	DT
10_1101-2021_02_13_429885	161	13	era	era	NN
10_1101-2021_02_13_429885	161	14	of	of	IN
10_1101-2021_02_13_429885	161	15	high	high	JJ
10_1101-2021_02_13_429885	161	16	-	-	HYPH
10_1101-2021_02_13_429885	161	17	resolution	resolution	NN
10_1101-2021_02_13_429885	161	18	whole	whole	JJ
10_1101-2021_02_13_429885	161	19	genome	genome	JJ
10_1101-2021_02_13_429885	161	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	161	21	.	.	.
10_1101-2021_02_13_429885	162	1	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	162	2	offers	offer	VBZ
10_1101-2021_02_13_429885	162	3	the	the	DT
10_1101-2021_02_13_429885	162	4	first	first	JJ
10_1101-2021_02_13_429885	162	5	principle	principle	JJ
10_1101-2021_02_13_429885	162	6	framework	framework	NN
10_1101-2021_02_13_429885	162	7	to	to	TO
10_1101-2021_02_13_429885	162	8	control	control	VB
10_1101-2021_02_13_429885	162	9	the	the	DT
10_1101-2021_02_13_429885	162	10	quality	quality	NN
10_1101-2021_02_13_429885	162	11	of	of	IN
10_1101-2021_02_13_429885	162	12	tumour	tumour	NN
10_1101-2021_02_13_429885	162	13	mutation	mutation	NN
10_1101-2021_02_13_429885	162	14	calls	call	NNS
10_1101-2021_02_13_429885	162	15	.	.	.
10_1101-2021_02_13_429885	163	1	The	the	DT
10_1101-2021_02_13_429885	163	2	tool	tool	NN
10_1101-2021_02_13_429885	163	3	can	can	MD
10_1101-2021_02_13_429885	163	4	analyse	analyse	VB
10_1101-2021_02_13_429885	163	5	SNVs	SNVs	NNPS
10_1101-2021_02_13_429885	163	6	and	and	CC
10_1101-2021_02_13_429885	163	7	more	more	JJR
10_1101-2021_02_13_429885	163	8	general	general	JJ
10_1101-2021_02_13_429885	163	9	types	type	NNS
10_1101-2021_02_13_429885	163	10	of	of	IN
10_1101-2021_02_13_429885	163	11	nucleotide	nucleotide	JJ
10_1101-2021_02_13_429885	163	12	substitutions	substitution	NNS
10_1101-2021_02_13_429885	163	13	;	;	:
10_1101-2021_02_13_429885	163	14	SNVs	SNVs	NNPS
10_1101-2021_02_13_429885	163	15	are	be	VBP
10_1101-2021_02_13_429885	163	16	more	more	RBR
10_1101-2021_02_13_429885	163	17	reliable	reliable	JJ
10_1101-2021_02_13_429885	163	18	and	and	CC
10_1101-2021_02_13_429885	163	19	depend	depend	VB
10_1101-2021_02_13_429885	163	20	less	less	RBR
10_1101-2021_02_13_429885	163	21	on	on	IN
10_1101-2021_02_13_429885	163	22	alignment	alignment	NN
10_1101-2021_02_13_429885	163	23	quality	quality	NN
10_1101-2021_02_13_429885	163	24	than	than	IN
10_1101-2021_02_13_429885	163	25	other	other	JJ
10_1101-2021_02_13_429885	163	26	mutations	mutation	NNS
10_1101-2021_02_13_429885	163	27	,	,	,
10_1101-2021_02_13_429885	163	28	and	and	CC
10_1101-2021_02_13_429885	163	29	therefore	therefore	RB
10_1101-2021_02_13_429885	163	30	should	should	MD
10_1101-2021_02_13_429885	163	31	be	be	VB
10_1101-2021_02_13_429885	163	32	checked	check	VBN
10_1101-2021_02_13_429885	163	33	first	first	RB
10_1101-2021_02_13_429885	163	34	.	.	.
10_1101-2021_02_13_429885	164	1	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	164	2	uses	use	VBZ
10_1101-2021_02_13_429885	164	3	a	a	DT
10_1101-2021_02_13_429885	164	4	peak	peak	NN
10_1101-2021_02_13_429885	164	5	-	-	HYPH
10_1101-2021_02_13_429885	164	6	detection	detection	NN
10_1101-2021_02_13_429885	164	7	analysis	analysis	NN
10_1101-2021_02_13_429885	164	8	to	to	TO
10_1101-2021_02_13_429885	164	9	validate	validate	VB
10_1101-2021_02_13_429885	164	10	CNA	CNA	NNP
10_1101-2021_02_13_429885	164	11	segments	segment	NNS
10_1101-2021_02_13_429885	164	12	and	and	CC
10_1101-2021_02_13_429885	164	13	purity	purity	NN
10_1101-2021_02_13_429885	164	14	,	,	,
10_1101-2021_02_13_429885	164	15	exploiting	exploit	VBG
10_1101-2021_02_13_429885	164	16	a	a	DT
10_1101-2021_02_13_429885	164	17	combinatorial	combinatorial	JJ
10_1101-2021_02_13_429885	164	18	model	model	NN
10_1101-2021_02_13_429885	164	19	for	for	IN
10_1101-2021_02_13_429885	164	20	cancer	cancer	NN
10_1101-2021_02_13_429885	164	21	alleles	allele	NNS
10_1101-2021_02_13_429885	164	22	.	.	.
10_1101-2021_02_13_429885	165	1	Within	within	IN
10_1101-2021_02_13_429885	165	2	the	the	DT
10_1101-2021_02_13_429885	165	3	same	same	JJ
10_1101-2021_02_13_429885	165	4	framework	framework	NN
10_1101-2021_02_13_429885	165	5	,	,	,
10_1101-2021_02_13_429885	165	6	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	165	7	also	also	RB
10_1101-2021_02_13_429885	165	8	computes	compute	VBZ
10_1101-2021_02_13_429885	165	9	CCF	ccf	NN
10_1101-2021_02_13_429885	165	10	values	value	NNS
10_1101-2021_02_13_429885	165	11	,	,	,
10_1101-2021_02_13_429885	165	12	highlighting	highlight	VBG
10_1101-2021_02_13_429885	165	13	mutations	mutation	NNS
10_1101-2021_02_13_429885	165	14	for	for	IN
10_1101-2021_02_13_429885	165	15	which	which	WDT
10_1101-2021_02_13_429885	165	16	such	such	JJ
10_1101-2021_02_13_429885	165	17	values	value	NNS
10_1101-2021_02_13_429885	165	18	are	be	VBP
10_1101-2021_02_13_429885	165	19	uncertain	uncertain	JJ
10_1101-2021_02_13_429885	165	20	.	.	.
10_1101-2021_02_13_429885	166	1	CNAqc	cnaqc	NN
10_1101-2021_02_13_429885	166	2	features	feature	NNS
10_1101-2021_02_13_429885	166	3	can	can	MD
10_1101-2021_02_13_429885	166	4	be	be	VB
10_1101-2021_02_13_429885	166	5	used	use	VBN
10_1101-2021_02_13_429885	166	6	to	to	TO
10_1101-2021_02_13_429885	166	7	clean	clean	VB
10_1101-2021_02_13_429885	166	8	up	up	RP
10_1101-2021_02_13_429885	166	9	data	datum	NNS
10_1101-2021_02_13_429885	166	10	,	,	,
10_1101-2021_02_13_429885	166	11	automatising	automatise	VBG
10_1101-2021_02_13_429885	166	12	parameter	parameter	NN
10_1101-2021_02_13_429885	166	13	choice	choice	NN
10_1101-2021_02_13_429885	166	14	for	for	IN
10_1101-2021_02_13_429885	166	15	virtually	virtually	RB
10_1101-2021_02_13_429885	166	16	any	any	DT
10_1101-2021_02_13_429885	166	17	caller	caller	NN
10_1101-2021_02_13_429885	166	18	,	,	,
10_1101-2021_02_13_429885	166	19	prioritizing	prioritize	VBG
10_1101-2021_02_13_429885	166	20	good	good	JJ
10_1101-2021_02_13_429885	166	21	calls	call	NNS
10_1101-2021_02_13_429885	166	22	and	and	CC
10_1101-2021_02_13_429885	166	23	selecting	select	VBG
10_1101-2021_02_13_429885	166	24	information	information	NN
10_1101-2021_02_13_429885	166	25	for	for	IN
10_1101-2021_02_13_429885	166	26	downstream	downstream	JJ
10_1101-2021_02_13_429885	166	27	analyses	analysis	NNS
10_1101-2021_02_13_429885	166	28	.	.	.
10_1101-2021_02_13_429885	167	1	The	the	DT
10_1101-2021_02_13_429885	167	2	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	167	3	framework	framework	NN
10_1101-2021_02_13_429885	167	4	leverages	leverage	VBZ
10_1101-2021_02_13_429885	167	5	the	the	DT
10_1101-2021_02_13_429885	167	6	relationship	relationship	NN
10_1101-2021_02_13_429885	167	7	between	between	IN
10_1101-2021_02_13_429885	167	8	tumour	tumour	NN
10_1101-2021_02_13_429885	167	9	VAF	VAF	NNP
10_1101-2021_02_13_429885	167	10	and	and	CC
10_1101-2021_02_13_429885	167	11	ploidy	ploidy	NN
10_1101-2021_02_13_429885	167	12	.	.	.
10_1101-2021_02_13_429885	168	1	The	the	DT
10_1101-2021_02_13_429885	168	2	quality	quality	NN
10_1101-2021_02_13_429885	168	3	of	of	IN
10_1101-2021_02_13_429885	168	4	the	the	DT
10_1101-2021_02_13_429885	168	5	control	control	NN
10_1101-2021_02_13_429885	168	6	process	process	NN
10_1101-2021_02_13_429885	168	7	itself	-PRON-	PRP
10_1101-2021_02_13_429885	168	8	depends	depend	VBZ
10_1101-2021_02_13_429885	168	9	on	on	IN
10_1101-2021_02_13_429885	168	10	the	the	DT
10_1101-2021_02_13_429885	168	11	ability	ability	NN
10_1101-2021_02_13_429885	168	12	to	to	TO
10_1101-2021_02_13_429885	168	13	process	process	VB
10_1101-2021_02_13_429885	168	14	the	the	DT
10_1101-2021_02_13_429885	168	15	VAF	VAF	NNP
10_1101-2021_02_13_429885	168	16	spectrum	spectrum	NN
10_1101-2021_02_13_429885	168	17	and	and	CC
10_1101-2021_02_13_429885	168	18	detect	detect	JJ
10_1101-2021_02_13_429885	168	19	peaks	peak	NNS
10_1101-2021_02_13_429885	168	20	.	.	.
10_1101-2021_02_13_429885	169	1	Therefore	therefore	RB
10_1101-2021_02_13_429885	169	2	,	,	,
10_1101-2021_02_13_429885	169	3	if	if	IN
10_1101-2021_02_13_429885	169	4	the	the	DT
10_1101-2021_02_13_429885	169	5	VAF	VAF	NNP
10_1101-2021_02_13_429885	169	6	quality	quality	NN
10_1101-2021_02_13_429885	169	7	is	be	VBZ
10_1101-2021_02_13_429885	169	8	very	very	RB
10_1101-2021_02_13_429885	169	9	low	low	JJ
10_1101-2021_02_13_429885	169	10	because	because	IN
10_1101-2021_02_13_429885	169	11	,	,	,
10_1101-2021_02_13_429885	169	12	e.g.	e.g.	RB
10_1101-2021_02_13_429885	169	13	,	,	,
10_1101-2021_02_13_429885	169	14	the	the	DT
10_1101-2021_02_13_429885	169	15	sample	sample	NN
10_1101-2021_02_13_429885	169	16	has	have	VBZ
10_1101-2021_02_13_429885	169	17	low	low	JJ
10_1101-2021_02_13_429885	169	18	purity	purity	NN
10_1101-2021_02_13_429885	169	19	or	or	CC
10_1101-2021_02_13_429885	169	20	coverage	coverage	NN
10_1101-2021_02_13_429885	169	21	,	,	,
10_1101-2021_02_13_429885	169	22	the	the	DT
10_1101-2021_02_13_429885	169	23	overall	overall	JJ
10_1101-2021_02_13_429885	169	24	quality	quality	NN
10_1101-2021_02_13_429885	169	25	of	of	IN
10_1101-2021_02_13_429885	169	26	the	the	DT
10_1101-2021_02_13_429885	169	27	check	check	NN
10_1101-2021_02_13_429885	169	28	decreases	decrease	NNS
10_1101-2021_02_13_429885	169	29	,	,	,
10_1101-2021_02_13_429885	169	30	making	make	VBG
10_1101-2021_02_13_429885	169	31	it	-PRON-	PRP
10_1101-2021_02_13_429885	169	32	more	more	RBR
10_1101-2021_02_13_429885	169	33	difficult	difficult	JJ
10_1101-2021_02_13_429885	169	34	to	to	TO
10_1101-2021_02_13_429885	169	35	completely	completely	RB
10_1101-2021_02_13_429885	169	36	automate	automate	VB
10_1101-2021_02_13_429885	169	37	quality	quality	NN
10_1101-2021_02_13_429885	169	38	checking	checking	NN
10_1101-2021_02_13_429885	169	39	.	.	.
10_1101-2021_02_13_429885	170	1	However	however	RB
10_1101-2021_02_13_429885	170	2	,	,	,
10_1101-2021_02_13_429885	170	3	for	for	IN
10_1101-2021_02_13_429885	170	4	the	the	DT
10_1101-2021_02_13_429885	170	5	large	large	JJ
10_1101-2021_02_13_429885	170	6	majority	majority	NN
10_1101-2021_02_13_429885	170	7	of	of	IN
10_1101-2021_02_13_429885	170	8	samples	sample	NNS
10_1101-2021_02_13_429885	170	9	,	,	,
10_1101-2021_02_13_429885	170	10	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	170	11	provides	provide	VBZ
10_1101-2021_02_13_429885	170	12	a	a	DT
10_1101-2021_02_13_429885	170	13	very	very	RB
10_1101-2021_02_13_429885	170	14	effective	effective	JJ
10_1101-2021_02_13_429885	170	15	and	and	CC
10_1101-2021_02_13_429885	170	16	fast	fast	JJ
10_1101-2021_02_13_429885	170	17	way	way	NN
10_1101-2021_02_13_429885	170	18	to	to	TO
10_1101-2021_02_13_429885	170	19	integrate	integrate	VB
10_1101-2021_02_13_429885	170	20	quality	quality	NN
10_1101-2021_02_13_429885	170	21	metrics	metric	NNS
10_1101-2021_02_13_429885	170	22	in	in	IN
10_1101-2021_02_13_429885	170	23	standard	standard	JJ
10_1101-2021_02_13_429885	170	24	pipelines	pipeline	NNS
10_1101-2021_02_13_429885	170	25	.	.	.
10_1101-2021_02_13_429885	171	1	Generating	generate	VBG
10_1101-2021_02_13_429885	171	2	high	high	JJ
10_1101-2021_02_13_429885	171	3	quality	quality	NN
10_1101-2021_02_13_429885	171	4	calls	call	NNS
10_1101-2021_02_13_429885	171	5	is	be	VBZ
10_1101-2021_02_13_429885	171	6	just	just	RB
10_1101-2021_02_13_429885	171	7	a	a	DT
10_1101-2021_02_13_429885	171	8	prelude	prelude	NN
10_1101-2021_02_13_429885	171	9	to	to	IN
10_1101-2021_02_13_429885	171	10	more	more	RBR
10_1101-2021_02_13_429885	171	11	complex	complex	JJ
10_1101-2021_02_13_429885	171	12	analyses	analysis	NNS
10_1101-2021_02_13_429885	171	13	that	that	WDT
10_1101-2021_02_13_429885	171	14	interpret	interpret	VBP
10_1101-2021_02_13_429885	171	15	cancer	cancer	NN
10_1101-2021_02_13_429885	171	16	genotypes	genotype	NNS
10_1101-2021_02_13_429885	171	17	and	and	CC
10_1101-2021_02_13_429885	171	18	their	-PRON-	PRP$
10_1101-2021_02_13_429885	171	19	history	history	NN
10_1101-2021_02_13_429885	171	20	,	,	,
10_1101-2021_02_13_429885	171	21	with	with	IN
10_1101-2021_02_13_429885	171	22	and	and	CC
10_1101-2021_02_13_429885	171	23	without	without	IN
10_1101-2021_02_13_429885	171	24	therapy	therapy	NN
10_1101-2021_02_13_429885	171	25	​(Ding	​(Ding	NNP
10_1101-2021_02_13_429885	171	26	et	et	NNP
10_1101-2021_02_13_429885	171	27	al	al	NNP
10_1101-2021_02_13_429885	171	28	.	.	.
10_1101-2021_02_13_429885	172	1	2012	2012	CD
10_1101-2021_02_13_429885	172	2	;	;	:
10_1101-2021_02_13_429885	172	3	Landau	Landau	NNP
10_1101-2021_02_13_429885	172	4	et	et	NNP
10_1101-2021_02_13_429885	172	5	al	al	NNP
10_1101-2021_02_13_429885	172	6	.	.	.
10_1101-2021_02_13_429885	173	1	2013	2013	CD
10_1101-2021_02_13_429885	173	2	;	;	:
10_1101-2021_02_13_429885	173	3	Caravagna	Caravagna	NNP
10_1101-2021_02_13_429885	173	4	et	et	NNP
10_1101-2021_02_13_429885	173	5	al	al	NNP
10_1101-2021_02_13_429885	173	6	.	.	.
10_1101-2021_02_13_429885	174	1	07	07	CD
10_1101-2021_02_13_429885	174	2	12	12	CD
10_1101-2021_02_13_429885	174	3	,	,	,
10_1101-2021_02_13_429885	174	4	2016	2016	CD
10_1101-2021_02_13_429885	174	5	;	;	:
10_1101-2021_02_13_429885	174	6	Jamal	Jamal	NNP
10_1101-2021_02_13_429885	174	7	-	-	HYPH
10_1101-2021_02_13_429885	174	8	Hanjani	Hanjani	NNP
10_1101-2021_02_13_429885	174	9	et	et	NNP
10_1101-2021_02_13_429885	174	10	al	al	NNP
10_1101-2021_02_13_429885	174	11	.	.	.
10_1101-2021_02_13_429885	175	1	2017	2017	CD
10_1101-2021_02_13_429885	175	2	;	;	:
10_1101-2021_02_13_429885	175	3	Turajlic	Turajlic	NNP
10_1101-2021_02_13_429885	175	4	et	et	FW
10_1101-2021_02_13_429885	175	5	al	al	NNP
10_1101-2021_02_13_429885	175	6	.	.	.
10_1101-2021_02_13_429885	176	1	2018	2018	CD
10_1101-2021_02_13_429885	176	2	;	;	:
10_1101-2021_02_13_429885	176	3	Caravagna	Caravagna	NNP
10_1101-2021_02_13_429885	176	4	et	et	NNP
10_1101-2021_02_13_429885	176	5	al	al	NNP
10_1101-2021_02_13_429885	176	6	.	.	.
10_1101-2021_02_13_429885	177	1	09	09	CD
10_1101-2021_02_13_429885	177	2	2018)​.	2018)​.	CD
10_1101-2021_02_13_429885	178	1	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	178	2	can	can	MD
10_1101-2021_02_13_429885	178	3	pass	pass	VB
10_1101-2021_02_13_429885	178	4	a	a	DT
10_1101-2021_02_13_429885	178	5	sample	sample	NN
10_1101-2021_02_13_429885	178	6	at	at	IN
10_1101-2021_02_13_429885	178	7	an	an	DT
10_1101-2021_02_13_429885	178	8	early	early	JJ
10_1101-2021_02_13_429885	178	9	stage	stage	NN
10_1101-2021_02_13_429885	178	10	,	,	,
10_1101-2021_02_13_429885	178	11	leaving	leave	VBG
10_1101-2021_02_13_429885	178	12	the	the	DT
10_1101-2021_02_13_429885	178	13	possibility	possibility	NN
10_1101-2021_02_13_429885	178	14	of	of	IN
10_1101-2021_02_13_429885	178	15	assessing	assessing	NN
10_1101-2021_02_13_429885	178	16	,	,	,
10_1101-2021_02_13_429885	178	17	at	at	IN
10_1101-2021_02_13_429885	178	18	a	a	DT
10_1101-2021_02_13_429885	178	19	later	later	JJ
10_1101-2021_02_13_429885	178	20	stage	stage	NN
10_1101-2021_02_13_429885	178	21	,	,	,
10_1101-2021_02_13_429885	178	22	whether	whether	IN
10_1101-2021_02_13_429885	178	23	the	the	DT
10_1101-2021_02_13_429885	178	24	quality	quality	NN
10_1101-2021_02_13_429885	178	25	of	of	IN
10_1101-2021_02_13_429885	178	26	the	the	DT
10_1101-2021_02_13_429885	178	27	data	datum	NNS
10_1101-2021_02_13_429885	178	28	is	be	VBZ
10_1101-2021_02_13_429885	178	29	high	high	JJ
10_1101-2021_02_13_429885	178	30	enough	enough	RB
10_1101-2021_02_13_429885	178	31	to	to	TO
10_1101-2021_02_13_429885	178	32	approach	approach	VB
10_1101-2021_02_13_429885	178	33	specific	specific	JJ
10_1101-2021_02_13_429885	178	34	research	research	NN
10_1101-2021_02_13_429885	178	35	questions	question	NNS
10_1101-2021_02_13_429885	178	36	.	.	.
10_1101-2021_02_13_429885	179	1	With	with	IN
10_1101-2021_02_13_429885	179	2	the	the	DT
10_1101-2021_02_13_429885	179	3	ongoing	ongoing	JJ
10_1101-2021_02_13_429885	179	4	implementation	implementation	NN
10_1101-2021_02_13_429885	179	5	of	of	IN
10_1101-2021_02_13_429885	179	6	large	large	JJ
10_1101-2021_02_13_429885	179	7	-	-	HYPH
10_1101-2021_02_13_429885	179	8	scale	scale	NN
10_1101-2021_02_13_429885	179	9	sequencing	sequencing	NN
10_1101-2021_02_13_429885	179	10	efforts	effort	NNS
10_1101-2021_02_13_429885	179	11	,	,	,
10_1101-2021_02_13_429885	179	12	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	179	13	provides	provide	VBZ
10_1101-2021_02_13_429885	179	14	a	a	DT
10_1101-2021_02_13_429885	179	15	good	good	JJ
10_1101-2021_02_13_429885	179	16	solution	solution	NN
10_1101-2021_02_13_429885	179	17	for	for	IN
10_1101-2021_02_13_429885	179	18	modular	modular	JJ
10_1101-2021_02_13_429885	179	19	pipelines	pipeline	NNS
10_1101-2021_02_13_429885	179	20	that	that	IN
10_1101-2021_02_13_429885	179	21	self	self	NN
10_1101-2021_02_13_429885	179	22	-	-	HYPH
10_1101-2021_02_13_429885	179	23	tune	tune	NN
10_1101-2021_02_13_429885	179	24	parameters	parameter	NNS
10_1101-2021_02_13_429885	179	25	,	,	,
10_1101-2021_02_13_429885	179	26	based	base	VBN
10_1101-2021_02_13_429885	179	27	on	on	IN
10_1101-2021_02_13_429885	179	28	quality	quality	NN
10_1101-2021_02_13_429885	179	29	scores	score	NNS
10_1101-2021_02_13_429885	179	30	.	.	.
10_1101-2021_02_13_429885	180	1	To	to	IN
10_1101-2021_02_13_429885	180	2	our	-PRON-	PRP$
10_1101-2021_02_13_429885	180	3	knowledge	knowledge	NN
10_1101-2021_02_13_429885	180	4	,	,	,
10_1101-2021_02_13_429885	180	5	this	this	DT
10_1101-2021_02_13_429885	180	6	is	be	VBZ
10_1101-2021_02_13_429885	180	7	the	the	DT
10_1101-2021_02_13_429885	180	8	first	first	JJ
10_1101-2021_02_13_429885	180	9	stand	stand	VB
10_1101-2021_02_13_429885	180	10	-	-	HYPH
10_1101-2021_02_13_429885	180	11	alone	alone	RB
10_1101-2021_02_13_429885	180	12	tool	tool	NN
10_1101-2021_02_13_429885	180	13	which	which	WDT
10_1101-2021_02_13_429885	180	14	leverages	leverage	VBZ
10_1101-2021_02_13_429885	180	15	the	the	DT
10_1101-2021_02_13_429885	180	16	power	power	NN
10_1101-2021_02_13_429885	180	17	of	of	IN
10_1101-2021_02_13_429885	180	18	combining	combine	VBG
10_1101-2021_02_13_429885	180	19	the	the	DT
10_1101-2021_02_13_429885	180	20	most	most	RBS
10_1101-2021_02_13_429885	180	21	common	common	JJ
10_1101-2021_02_13_429885	180	22	types	type	NNS
10_1101-2021_02_13_429885	180	23	of	of	IN
10_1101-2021_02_13_429885	180	24	cancer	cancer	NN
10_1101-2021_02_13_429885	180	25	mutations	mutation	NNS
10_1101-2021_02_13_429885	180	26	-	-	,
10_1101-2021_02_13_429885	180	27	SNVs	snv	NNS
10_1101-2021_02_13_429885	180	28	and	and	CC
10_1101-2021_02_13_429885	180	29	CNAs	cna	NNS
10_1101-2021_02_13_429885	180	30	-	-	,
10_1101-2021_02_13_429885	180	31	to	to	TO
10_1101-2021_02_13_429885	180	32	automatically	automatically	RB
10_1101-2021_02_13_429885	180	33	control	control	VB
10_1101-2021_02_13_429885	180	34	the	the	DT
10_1101-2021_02_13_429885	180	35	quality	quality	NN
10_1101-2021_02_13_429885	180	36	of	of	IN
10_1101-2021_02_13_429885	180	37	WGS	WGS	NNP
10_1101-2021_02_13_429885	180	38	assays	assays	RB
10_1101-2021_02_13_429885	180	39	.	.	.
10_1101-2021_02_13_429885	181	1	We	-PRON-	PRP
10_1101-2021_02_13_429885	181	2	believe	believe	VBP
10_1101-2021_02_13_429885	181	3	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	181	4	can	can	MD
10_1101-2021_02_13_429885	181	5	help	help	VB
10_1101-2021_02_13_429885	181	6	reduce	reduce	VB
10_1101-2021_02_13_429885	181	7	the	the	DT
10_1101-2021_02_13_429885	181	8	burden	burden	NN
10_1101-2021_02_13_429885	181	9	of	of	IN
10_1101-2021_02_13_429885	181	10	manual	manual	JJ
10_1101-2021_02_13_429885	181	11	quality	quality	NN
10_1101-2021_02_13_429885	181	12	checking	checking	NN
10_1101-2021_02_13_429885	181	13	and	and	CC
10_1101-2021_02_13_429885	181	14	parameter	parameter	NN
10_1101-2021_02_13_429885	181	15	tuning	tuning	NN
10_1101-2021_02_13_429885	181	16	.	.	.
10_1101-2021_02_13_429885	182	1	References	References	NNPS
10_1101-2021_02_13_429885	182	2	Bailey	Bailey	NNP
10_1101-2021_02_13_429885	182	3	,	,	,
10_1101-2021_02_13_429885	182	4	Matthew	Matthew	NNP
10_1101-2021_02_13_429885	182	5	H.	H.	NNP
10_1101-2021_02_13_429885	182	6	,	,	,
10_1101-2021_02_13_429885	182	7	Collin	Collin	NNP
10_1101-2021_02_13_429885	182	8	Tokheim	Tokheim	NNP
10_1101-2021_02_13_429885	182	9	,	,	,
10_1101-2021_02_13_429885	182	10	Eduard	Eduard	NNP
10_1101-2021_02_13_429885	182	11	Porta	Porta	NNP
10_1101-2021_02_13_429885	182	12	-	-	HYPH
10_1101-2021_02_13_429885	182	13	Pardo	Pardo	NNP
10_1101-2021_02_13_429885	182	14	,	,	,
10_1101-2021_02_13_429885	182	15	Sohini	Sohini	NNP
10_1101-2021_02_13_429885	182	16	Sengupta	Sengupta	NNP
10_1101-2021_02_13_429885	182	17	,	,	,
10_1101-2021_02_13_429885	182	18	Denis	Denis	NNP
10_1101-2021_02_13_429885	182	19	Bertrand	Bertrand	NNP
10_1101-2021_02_13_429885	182	20	,	,	,
10_1101-2021_02_13_429885	182	21	Amila	Amila	NNP
10_1101-2021_02_13_429885	182	22	Weerasinghe	Weerasinghe	NNP
10_1101-2021_02_13_429885	182	23	,	,	,
10_1101-2021_02_13_429885	182	24	Antonio	Antonio	NNP
10_1101-2021_02_13_429885	182	25	Colaprico	Colaprico	NNP
10_1101-2021_02_13_429885	182	26	,	,	,
10_1101-2021_02_13_429885	182	27	et	et	NNP
10_1101-2021_02_13_429885	182	28	al	al	NNP
10_1101-2021_02_13_429885	182	29	.	.	.
10_1101-2021_02_13_429885	183	1	2018	2018	CD
10_1101-2021_02_13_429885	183	2	.	.	.
10_1101-2021_02_13_429885	184	1	“	"	``
10_1101-2021_02_13_429885	184	2	Comprehensive	comprehensive	JJ
10_1101-2021_02_13_429885	184	3	Characterization	characterization	NN
10_1101-2021_02_13_429885	184	4	of	of	IN
10_1101-2021_02_13_429885	184	5	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	184	6	Driver	Driver	NNP
10_1101-2021_02_13_429885	184	7	Genes	Genes	NNP
10_1101-2021_02_13_429885	184	8	and	and	CC
10_1101-2021_02_13_429885	184	9	Mutations	Mutations	NNPS
10_1101-2021_02_13_429885	184	10	.	.	.
10_1101-2021_02_13_429885	184	11	”	"	''
10_1101-2021_02_13_429885	184	12	​Cell​	​Cell​	NNP
10_1101-2021_02_13_429885	184	13	173	173	CD
10_1101-2021_02_13_429885	184	14	(	(	-LRB-
10_1101-2021_02_13_429885	184	15	2	2	CD
10_1101-2021_02_13_429885	184	16	)	)	-RRB-
10_1101-2021_02_13_429885	184	17	:	:	:
10_1101-2021_02_13_429885	184	18	371–85.e18	371–85.e18	LS
10_1101-2021_02_13_429885	184	19	.	.	.
10_1101-2021_02_13_429885	185	1	https://doi.org/​10.1016/j.cell.2018.02.060	https://doi.org/​10.1016/j.cell.2018.02.060	NNP
10_1101-2021_02_13_429885	185	2	​.	​.	NNP
10_1101-2021_02_13_429885	186	1	Barnell	Barnell	NNP
10_1101-2021_02_13_429885	186	2	,	,	,
10_1101-2021_02_13_429885	186	3	Erica	Erica	NNP
10_1101-2021_02_13_429885	186	4	K.	K.	NNP
10_1101-2021_02_13_429885	186	5	,	,	,
10_1101-2021_02_13_429885	186	6	Peter	Peter	NNP
10_1101-2021_02_13_429885	186	7	Ronning	Ronning	NNP
10_1101-2021_02_13_429885	186	8	,	,	,
10_1101-2021_02_13_429885	186	9	Katie	Katie	NNP
10_1101-2021_02_13_429885	186	10	M.	M.	NNP
10_1101-2021_02_13_429885	186	11	Campbell	Campbell	NNP
10_1101-2021_02_13_429885	186	12	,	,	,
10_1101-2021_02_13_429885	186	13	Kilannin	Kilannin	NNP
10_1101-2021_02_13_429885	186	14	Krysiak	Krysiak	NNP
10_1101-2021_02_13_429885	186	15	,	,	,
10_1101-2021_02_13_429885	186	16	Benjamin	Benjamin	NNP
10_1101-2021_02_13_429885	186	17	J.	J.	NNP
10_1101-2021_02_13_429885	186	18	Ainscough	Ainscough	NNP
10_1101-2021_02_13_429885	186	19	,	,	,
10_1101-2021_02_13_429885	186	20	Lana	Lana	NNP
10_1101-2021_02_13_429885	186	21	M.	M.	NNP
10_1101-2021_02_13_429885	186	22	Sheta	Sheta	NNP
10_1101-2021_02_13_429885	186	23	,	,	,
10_1101-2021_02_13_429885	186	24	Shahil	Shahil	NNP
10_1101-2021_02_13_429885	186	25	P.	P.	NNP
10_1101-2021_02_13_429885	186	26	Pema	Pema	NNP
10_1101-2021_02_13_429885	186	27	,	,	,
10_1101-2021_02_13_429885	186	28	et	et	NNP
10_1101-2021_02_13_429885	186	29	al	al	NNP
10_1101-2021_02_13_429885	186	30	.	.	.
10_1101-2021_02_13_429885	187	1	2019	2019	CD
10_1101-2021_02_13_429885	187	2	.	.	.
10_1101-2021_02_13_429885	188	1	“	"	``
10_1101-2021_02_13_429885	188	2	Standard	Standard	NNP
10_1101-2021_02_13_429885	188	3	Operating	Operating	NNP
10_1101-2021_02_13_429885	188	4	Procedure	Procedure	NNP
10_1101-2021_02_13_429885	188	5	for	for	IN
10_1101-2021_02_13_429885	188	6	Somatic	Somatic	NNP
10_1101-2021_02_13_429885	188	7	Variant	Variant	NNP
10_1101-2021_02_13_429885	188	8	Refinement	Refinement	NNP
10_1101-2021_02_13_429885	188	9	of	of	IN
10_1101-2021_02_13_429885	188	10	Sequencing	Sequencing	NNP
10_1101-2021_02_13_429885	188	11	Data	Data	NNP
10_1101-2021_02_13_429885	188	12	with	with	IN
10_1101-2021_02_13_429885	188	13	Paired	Paired	NNP
10_1101-2021_02_13_429885	188	14	Tumor	Tumor	NNP
10_1101-2021_02_13_429885	188	15	and	and	CC
10_1101-2021_02_13_429885	188	16	Normal	Normal	NNP
10_1101-2021_02_13_429885	188	17	Samples	Samples	NNPS
10_1101-2021_02_13_429885	188	18	.	.	.
10_1101-2021_02_13_429885	188	19	”	"	''
10_1101-2021_02_13_429885	188	20	​Genetics	​genetic	NNS
10_1101-2021_02_13_429885	188	21	.CC	.CC	NFP
10_1101-2021_02_13_429885	188	22	-	-	HYPH
10_1101-2021_02_13_429885	188	23	BY	by	IN
10_1101-2021_02_13_429885	188	24	-	-	HYPH
10_1101-2021_02_13_429885	188	25	NC	NC	NNP
10_1101-2021_02_13_429885	188	26	-	-	HYPH
10_1101-2021_02_13_429885	188	27	ND	ND	NNP
10_1101-2021_02_13_429885	188	28	4.0	4.0	CD
10_1101-2021_02_13_429885	188	29	International	International	NNP
10_1101-2021_02_13_429885	188	30	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	188	31	under	under	IN
10_1101-2021_02_13_429885	188	32	a	a	DT
10_1101-2021_02_13_429885	188	33	(	(	-LRB-
10_1101-2021_02_13_429885	188	34	which	which	WDT
10_1101-2021_02_13_429885	188	35	was	be	VBD
10_1101-2021_02_13_429885	188	36	not	not	RB
10_1101-2021_02_13_429885	188	37	certified	certify	VBN
10_1101-2021_02_13_429885	188	38	by	by	IN
10_1101-2021_02_13_429885	188	39	peer	peer	NN
10_1101-2021_02_13_429885	188	40	review	review	NN
10_1101-2021_02_13_429885	188	41	)	)	-RRB-
10_1101-2021_02_13_429885	188	42	is	be	VBZ
10_1101-2021_02_13_429885	188	43	the	the	DT
10_1101-2021_02_13_429885	188	44	author	author	NN
10_1101-2021_02_13_429885	188	45	/	/	SYM
10_1101-2021_02_13_429885	188	46	funder	funder	NN
10_1101-2021_02_13_429885	188	47	,	,	,
10_1101-2021_02_13_429885	188	48	who	who	WP
10_1101-2021_02_13_429885	188	49	has	have	VBZ
10_1101-2021_02_13_429885	188	50	granted	grant	VBN
10_1101-2021_02_13_429885	188	51	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	188	52	a	a	DT
10_1101-2021_02_13_429885	188	53	license	license	NN
10_1101-2021_02_13_429885	188	54	to	to	TO
10_1101-2021_02_13_429885	188	55	display	display	VB
10_1101-2021_02_13_429885	188	56	the	the	DT
10_1101-2021_02_13_429885	188	57	preprint	preprint	NN
10_1101-2021_02_13_429885	188	58	in	in	IN
10_1101-2021_02_13_429885	188	59	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	188	60	.	.	.
10_1101-2021_02_13_429885	189	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	189	2	is	be	VBZ
10_1101-2021_02_13_429885	189	3	made	make	VBN
10_1101-2021_02_13_429885	189	4	The	the	DT
10_1101-2021_02_13_429885	189	5	copyright	copyright	NN
10_1101-2021_02_13_429885	189	6	holder	holder	NN
10_1101-2021_02_13_429885	189	7	for	for	IN
10_1101-2021_02_13_429885	189	8	this	this	DT
10_1101-2021_02_13_429885	189	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	189	10	version	version	NN
10_1101-2021_02_13_429885	189	11	posted	post	VBD
10_1101-2021_02_13_429885	189	12	February	February	NNP
10_1101-2021_02_13_429885	189	13	13	13	CD
10_1101-2021_02_13_429885	189	14	,	,	,
10_1101-2021_02_13_429885	189	15	2021	2021	CD
10_1101-2021_02_13_429885	189	16	.	.	.
10_1101-2021_02_13_429885	189	17	;	;	:
10_1101-2021_02_13_429885	189	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	189	19	:	:	:
10_1101-2021_02_13_429885	189	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	189	21	preprint	preprint	NN
10_1101-2021_02_13_429885	189	22	https://paperpile.com/c/rqVmzs/wPG3+tqeT+Rl5f+CImd+JI4a+eR0S	https://paperpile.com/c/rqvmzs/wpg3+tqet+rl5f+cimd+ji4a+er0s	UH
10_1101-2021_02_13_429885	189	23	https://paperpile.com/c/rqVmzs/wPG3+tqeT+Rl5f+CImd+JI4a+eR0S	https://paperpile.com/c/rqvmzs/wpg3+tqet+rl5f+cimd+ji4a+er0s	UH
10_1101-2021_02_13_429885	189	24	https://paperpile.com/c/rqVmzs/wPG3+tqeT+Rl5f+CImd+JI4a+eR0S	https://paperpile.com/c/rqvmzs/wpg3+tqet+rl5f+cimd+ji4a+er0s	UH
10_1101-2021_02_13_429885	189	25	http://paperpile.com/b/rqVmzs/UEke	http://paperpile.com/b/rqvmzs/ueke	JJ
10_1101-2021_02_13_429885	189	26	http://paperpile.com/b/rqVmzs/UEke	http://paperpile.com/b/rqvmzs/ueke	JJ
10_1101-2021_02_13_429885	189	27	http://paperpile.com/b/rqVmzs/UEke	http://paperpile.com/b/rqvmzs/ueke	JJ
10_1101-2021_02_13_429885	189	28	http://paperpile.com/b/rqVmzs/UEke	http://paperpile.com/b/rqvmzs/ueke	JJ
10_1101-2021_02_13_429885	189	29	http://paperpile.com/b/rqVmzs/UEke	http://paperpile.com/b/rqvmzs/ueke	JJ
10_1101-2021_02_13_429885	189	30	http://paperpile.com/b/rqVmzs/UEke	http://paperpile.com/b/rqVmzs/UEke	NNS
10_1101-2021_02_13_429885	189	31	http://dx.doi.org/10.1016/j.cell.2018.02.060	http://dx.doi.org/10.1016/j.cell.2018.02.060	VBZ
10_1101-2021_02_13_429885	189	32	http://paperpile.com/b/rqVmzs/UEke	http://paperpile.com/b/rqVmzs/UEke	NNS
10_1101-2021_02_13_429885	189	33	http://paperpile.com/b/rqVmzs/j5j7	http://paperpile.com/b/rqVmzs/j5j7	NNS
10_1101-2021_02_13_429885	189	34	http://paperpile.com/b/rqVmzs/j5j7	http://paperpile.com/b/rqvmzs/j5j7	CD
10_1101-2021_02_13_429885	189	35	http://paperpile.com/b/rqVmzs/j5j7	http://paperpile.com/b/rqVmzs/j5j7	NNS
10_1101-2021_02_13_429885	189	36	http://paperpile.com/b/rqVmzs/j5j7	http://paperpile.com/b/rqVmzs/j5j7	NNS
10_1101-2021_02_13_429885	189	37	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	NNP
10_1101-2021_02_13_429885	189	38	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	189	39	Househam	Househam	NNP
10_1101-2021_02_13_429885	189	40	et	et	FW
10_1101-2021_02_13_429885	189	41	al	al	NNP
10_1101-2021_02_13_429885	189	42	.	.	.
10_1101-2021_02_13_429885	190	1	A	a	DT
10_1101-2021_02_13_429885	190	2	fully	fully	RB
10_1101-2021_02_13_429885	190	3	automated	automate	VBN
10_1101-2021_02_13_429885	190	4	approach	approach	NN
10_1101-2021_02_13_429885	190	5	for	for	IN
10_1101-2021_02_13_429885	190	6	quality	quality	NN
10_1101-2021_02_13_429885	190	7	control	control	NN
10_1101-2021_02_13_429885	190	8	of	of	IN
10_1101-2021_02_13_429885	190	9	cancer	cancer	NN
10_1101-2021_02_13_429885	190	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	190	11	in	in	IN
10_1101-2021_02_13_429885	190	12	the	the	DT
10_1101-2021_02_13_429885	190	13	era	era	NN
10_1101-2021_02_13_429885	190	14	of	of	IN
10_1101-2021_02_13_429885	190	15	high	high	JJ
10_1101-2021_02_13_429885	190	16	-	-	HYPH
10_1101-2021_02_13_429885	190	17	resolution	resolution	NN
10_1101-2021_02_13_429885	190	18	whole	whole	JJ
10_1101-2021_02_13_429885	190	19	genome	genome	JJ
10_1101-2021_02_13_429885	190	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	190	21	.	.	.
10_1101-2021_02_13_429885	191	1	in	in	IN
10_1101-2021_02_13_429885	191	2	Medicine	Medicine	NNP
10_1101-2021_02_13_429885	191	3	:	:	:
10_1101-2021_02_13_429885	191	4	Official	Official	NNP
10_1101-2021_02_13_429885	191	5	Journal	Journal	NNP
10_1101-2021_02_13_429885	191	6	of	of	IN
10_1101-2021_02_13_429885	191	7	the	the	DT
10_1101-2021_02_13_429885	191	8	American	American	NNP
10_1101-2021_02_13_429885	191	9	College	College	NNP
10_1101-2021_02_13_429885	191	10	of	of	IN
10_1101-2021_02_13_429885	191	11	Medical	Medical	NNP
10_1101-2021_02_13_429885	191	12	Genetics​	Genetics​	NNP
10_1101-2021_02_13_429885	191	13	21	21	CD
10_1101-2021_02_13_429885	191	14	(	(	-LRB-
10_1101-2021_02_13_429885	191	15	4	4	CD
10_1101-2021_02_13_429885	191	16	)	)	-RRB-
10_1101-2021_02_13_429885	191	17	:	:	:
10_1101-2021_02_13_429885	191	18	972–81	972–81	CD
10_1101-2021_02_13_429885	191	19	.	.	.
10_1101-2021_02_13_429885	192	1	https://doi.org/​10.1038/s41436-018-0278-z​.	https://doi.org/​10.1038/s41436-018-0278-z​.	LS
10_1101-2021_02_13_429885	193	1	Benjamin	Benjamin	NNP
10_1101-2021_02_13_429885	193	2	,	,	,
10_1101-2021_02_13_429885	193	3	David	David	NNP
10_1101-2021_02_13_429885	193	4	,	,	,
10_1101-2021_02_13_429885	193	5	Takuto	Takuto	NNP
10_1101-2021_02_13_429885	193	6	Sato	Sato	NNP
10_1101-2021_02_13_429885	193	7	,	,	,
10_1101-2021_02_13_429885	193	8	Kristian	kristian	JJ
10_1101-2021_02_13_429885	193	9	Cibulskis	Cibulskis	NNP
10_1101-2021_02_13_429885	193	10	,	,	,
10_1101-2021_02_13_429885	193	11	Gad	Gad	NNP
10_1101-2021_02_13_429885	193	12	Getz	Getz	NNP
10_1101-2021_02_13_429885	193	13	,	,	,
10_1101-2021_02_13_429885	193	14	Chip	Chip	NNP
10_1101-2021_02_13_429885	193	15	Stewart	Stewart	NNP
10_1101-2021_02_13_429885	193	16	,	,	,
10_1101-2021_02_13_429885	193	17	and	and	CC
10_1101-2021_02_13_429885	193	18	Lee	Lee	NNP
10_1101-2021_02_13_429885	193	19	Lichtenstein	Lichtenstein	NNP
10_1101-2021_02_13_429885	193	20	.	.	.
10_1101-2021_02_13_429885	194	1	2019	2019	CD
10_1101-2021_02_13_429885	194	2	.	.	.
10_1101-2021_02_13_429885	195	1	“	"	``
10_1101-2021_02_13_429885	195	2	Calling	call	VBG
10_1101-2021_02_13_429885	195	3	Somatic	somatic	JJ
10_1101-2021_02_13_429885	195	4	SNVs	SNVs	NNPS
10_1101-2021_02_13_429885	195	5	and	and	CC
10_1101-2021_02_13_429885	195	6	Indels	Indels	NNPS
10_1101-2021_02_13_429885	195	7	with	with	IN
10_1101-2021_02_13_429885	195	8	Mutect2	Mutect2	NNP
10_1101-2021_02_13_429885	195	9	.	.	.
10_1101-2021_02_13_429885	195	10	”	"	''
10_1101-2021_02_13_429885	195	11	​bioRxiv​	​bioRxiv​	NNP
10_1101-2021_02_13_429885	195	12	,	,	,
10_1101-2021_02_13_429885	195	13	December	December	NNP
10_1101-2021_02_13_429885	195	14	,	,	,
10_1101-2021_02_13_429885	195	15	861054	861054	CD
10_1101-2021_02_13_429885	195	16	.	.	.
10_1101-2021_02_13_429885	195	17	https://doi.org/​10.1101/861054	https://doi.org/​10.1101/861054	NNP
10_1101-2021_02_13_429885	195	18	​.	​.	NNP
10_1101-2021_02_13_429885	196	1	Boeva	Boeva	NNP
10_1101-2021_02_13_429885	196	2	,	,	,
10_1101-2021_02_13_429885	196	3	Valentina	Valentina	NNP
10_1101-2021_02_13_429885	196	4	,	,	,
10_1101-2021_02_13_429885	196	5	Andrei	Andrei	NNP
10_1101-2021_02_13_429885	196	6	Zinovyev	Zinovyev	NNP
10_1101-2021_02_13_429885	196	7	,	,	,
10_1101-2021_02_13_429885	196	8	Kevin	Kevin	NNP
10_1101-2021_02_13_429885	196	9	Bleakley	Bleakley	NNP
10_1101-2021_02_13_429885	196	10	,	,	,
10_1101-2021_02_13_429885	196	11	Jean	Jean	NNP
10_1101-2021_02_13_429885	196	12	-	-	HYPH
10_1101-2021_02_13_429885	196	13	Philippe	Philippe	NNP
10_1101-2021_02_13_429885	196	14	Vert	Vert	NNP
10_1101-2021_02_13_429885	196	15	,	,	,
10_1101-2021_02_13_429885	196	16	Isabelle	Isabelle	NNP
10_1101-2021_02_13_429885	196	17	Janoueix	Janoueix	NNP
10_1101-2021_02_13_429885	196	18	-	-	HYPH
10_1101-2021_02_13_429885	196	19	Lerosey	Lerosey	NNP
10_1101-2021_02_13_429885	196	20	,	,	,
10_1101-2021_02_13_429885	196	21	Olivier	Olivier	NNP
10_1101-2021_02_13_429885	196	22	Delattre	Delattre	NNP
10_1101-2021_02_13_429885	196	23	,	,	,
10_1101-2021_02_13_429885	196	24	and	and	CC
10_1101-2021_02_13_429885	196	25	Emmanuel	Emmanuel	NNP
10_1101-2021_02_13_429885	196	26	Barillot	Barillot	NNP
10_1101-2021_02_13_429885	196	27	.	.	.
10_1101-2021_02_13_429885	197	1	2011	2011	CD
10_1101-2021_02_13_429885	197	2	.	.	.
10_1101-2021_02_13_429885	198	1	“	"	``
10_1101-2021_02_13_429885	198	2	Control	Control	NNP
10_1101-2021_02_13_429885	198	3	-	-	HYPH
10_1101-2021_02_13_429885	198	4	Free	Free	NNP
10_1101-2021_02_13_429885	198	5	Calling	Calling	NNP
10_1101-2021_02_13_429885	198	6	of	of	IN
10_1101-2021_02_13_429885	198	7	Copy	Copy	NNP
10_1101-2021_02_13_429885	198	8	Number	Number	NNP
10_1101-2021_02_13_429885	198	9	Alterations	Alterations	NNPS
10_1101-2021_02_13_429885	198	10	in	in	IN
10_1101-2021_02_13_429885	198	11	Deep	Deep	NNP
10_1101-2021_02_13_429885	198	12	-	-	HYPH
10_1101-2021_02_13_429885	198	13	Sequencing	Sequencing	NNP
10_1101-2021_02_13_429885	198	14	Data	datum	NNS
10_1101-2021_02_13_429885	198	15	Using	use	VBG
10_1101-2021_02_13_429885	198	16	GC	GC	NNP
10_1101-2021_02_13_429885	198	17	-	-	HYPH
10_1101-2021_02_13_429885	198	18	Content	Content	NNP
10_1101-2021_02_13_429885	198	19	Normalization	Normalization	NNP
10_1101-2021_02_13_429885	198	20	.	.	.
10_1101-2021_02_13_429885	198	21	”	"	''
10_1101-2021_02_13_429885	198	22	Bioinformatics	Bioinformatics	NNP
10_1101-2021_02_13_429885	198	23	​	​	NNP
10_1101-2021_02_13_429885	198	24	27	27	CD
10_1101-2021_02_13_429885	198	25	(	(	-LRB-
10_1101-2021_02_13_429885	198	26	2	2	CD
10_1101-2021_02_13_429885	198	27	)	)	-RRB-
10_1101-2021_02_13_429885	198	28	:	:	:
10_1101-2021_02_13_429885	198	29	268–69	268–69	CD
10_1101-2021_02_13_429885	198	30	.	.	.
10_1101-2021_02_13_429885	199	1	https://doi.org/​10.1093/bioinformatics/btq635	https://doi.org/​10.1093/bioinformatics/btq635	PRP
10_1101-2021_02_13_429885	199	2	​.	​.	NNP
10_1101-2021_02_13_429885	200	1	Campbell	Campbell	NNP
10_1101-2021_02_13_429885	200	2	,	,	,
10_1101-2021_02_13_429885	200	3	Peter	Peter	NNP
10_1101-2021_02_13_429885	200	4	J.	J.	NNP
10_1101-2021_02_13_429885	200	5	,	,	,
10_1101-2021_02_13_429885	200	6	Gad	Gad	NNP
10_1101-2021_02_13_429885	200	7	Getz	Getz	NNP
10_1101-2021_02_13_429885	200	8	,	,	,
10_1101-2021_02_13_429885	200	9	Jan	Jan	NNP
10_1101-2021_02_13_429885	200	10	O.	O.	NNP
10_1101-2021_02_13_429885	200	11	Korbel	Korbel	NNP
10_1101-2021_02_13_429885	200	12	,	,	,
10_1101-2021_02_13_429885	200	13	Joshua	Joshua	NNP
10_1101-2021_02_13_429885	200	14	M.	M.	NNP
10_1101-2021_02_13_429885	200	15	Stuart	Stuart	NNP
10_1101-2021_02_13_429885	200	16	,	,	,
10_1101-2021_02_13_429885	200	17	Jennifer	Jennifer	NNP
10_1101-2021_02_13_429885	200	18	L.	L.	NNP
10_1101-2021_02_13_429885	200	19	Jennings	Jennings	NNP
10_1101-2021_02_13_429885	200	20	,	,	,
10_1101-2021_02_13_429885	200	21	Lincoln	Lincoln	NNP
10_1101-2021_02_13_429885	200	22	D.	D.	NNP
10_1101-2021_02_13_429885	200	23	Stein	Stein	NNP
10_1101-2021_02_13_429885	200	24	,	,	,
10_1101-2021_02_13_429885	200	25	Marc	Marc	NNP
10_1101-2021_02_13_429885	200	26	D.	D.	NNP
10_1101-2021_02_13_429885	200	27	Perry	Perry	NNP
10_1101-2021_02_13_429885	200	28	,	,	,
10_1101-2021_02_13_429885	200	29	et	et	NNP
10_1101-2021_02_13_429885	200	30	al	al	NNP
10_1101-2021_02_13_429885	200	31	.	.	.
10_1101-2021_02_13_429885	201	1	2020	2020	CD
10_1101-2021_02_13_429885	201	2	.	.	.
10_1101-2021_02_13_429885	202	1	“	"	``
10_1101-2021_02_13_429885	202	2	Pan	Pan	NNP
10_1101-2021_02_13_429885	202	3	-	-	NNP
10_1101-2021_02_13_429885	202	4	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	202	5	Analysis	Analysis	NNP
10_1101-2021_02_13_429885	202	6	of	of	IN
10_1101-2021_02_13_429885	202	7	Whole	Whole	NNP
10_1101-2021_02_13_429885	202	8	Genomes	Genomes	NNP
10_1101-2021_02_13_429885	202	9	.	.	.
10_1101-2021_02_13_429885	202	10	”	"	''
10_1101-2021_02_13_429885	202	11	​Nature​	​Nature​	NNP
10_1101-2021_02_13_429885	202	12	578	578	CD
10_1101-2021_02_13_429885	202	13	(	(	-LRB-
10_1101-2021_02_13_429885	202	14	7793	7793	CD
10_1101-2021_02_13_429885	202	15	)	)	-RRB-
10_1101-2021_02_13_429885	202	16	:	:	:
10_1101-2021_02_13_429885	202	17	82–93	82–93	CD
10_1101-2021_02_13_429885	202	18	.	.	.
10_1101-2021_02_13_429885	203	1	https://doi.org/​10.1038/s41586-020-1969-6	https://doi.org/​10.1038/s41586-020-1969-6	ADD
10_1101-2021_02_13_429885	203	2	​.	​.	CD
10_1101-2021_02_13_429885	204	1	Caravagna	Caravagna	NNP
10_1101-2021_02_13_429885	204	2	,	,	,
10_1101-2021_02_13_429885	204	3	Giulio	Giulio	NNP
10_1101-2021_02_13_429885	204	4	,	,	,
10_1101-2021_02_13_429885	204	5	Ylenia	Ylenia	NNP
10_1101-2021_02_13_429885	204	6	Giarratano	Giarratano	NNP
10_1101-2021_02_13_429885	204	7	,	,	,
10_1101-2021_02_13_429885	204	8	Daniele	Daniele	NNP
10_1101-2021_02_13_429885	204	9	Ramazzotti	Ramazzotti	NNP
10_1101-2021_02_13_429885	204	10	,	,	,
10_1101-2021_02_13_429885	204	11	Ian	Ian	NNP
10_1101-2021_02_13_429885	204	12	Tomlinson	Tomlinson	NNP
10_1101-2021_02_13_429885	204	13	,	,	,
10_1101-2021_02_13_429885	204	14	Trevor	Trevor	NNP
10_1101-2021_02_13_429885	204	15	A.	a.	NN
10_1101-2021_02_13_429885	204	16	Graham	Graham	NNP
10_1101-2021_02_13_429885	204	17	,	,	,
10_1101-2021_02_13_429885	204	18	Guido	Guido	NNP
10_1101-2021_02_13_429885	204	19	Sanguinetti	Sanguinetti	NNP
10_1101-2021_02_13_429885	204	20	,	,	,
10_1101-2021_02_13_429885	204	21	and	and	CC
10_1101-2021_02_13_429885	204	22	Andrea	Andrea	NNP
10_1101-2021_02_13_429885	204	23	Sottoriva	Sottoriva	NNP
10_1101-2021_02_13_429885	204	24	.	.	.
10_1101-2021_02_13_429885	205	1	09	09	CD
10_1101-2021_02_13_429885	205	2	2018	2018	CD
10_1101-2021_02_13_429885	205	3	.	.	.
10_1101-2021_02_13_429885	206	1	“	"	``
10_1101-2021_02_13_429885	206	2	Detecting	detect	VBG
10_1101-2021_02_13_429885	206	3	Repeated	repeat	VBN
10_1101-2021_02_13_429885	206	4	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	206	5	Evolution	Evolution	NNP
10_1101-2021_02_13_429885	206	6	from	from	IN
10_1101-2021_02_13_429885	206	7	Multi	Multi	NNP
10_1101-2021_02_13_429885	206	8	-	-	NNP
10_1101-2021_02_13_429885	206	9	Region	Region	NNP
10_1101-2021_02_13_429885	206	10	Tumor	Tumor	NNP
10_1101-2021_02_13_429885	206	11	Sequencing	Sequencing	NNP
10_1101-2021_02_13_429885	206	12	Data	Data	NNPS
10_1101-2021_02_13_429885	206	13	.	.	.
10_1101-2021_02_13_429885	206	14	”	"	''
10_1101-2021_02_13_429885	206	15	​Nature	​nature	JJ
10_1101-2021_02_13_429885	206	16	Methods​	Methods​	NNP
10_1101-2021_02_13_429885	206	17	15	15	CD
10_1101-2021_02_13_429885	206	18	(	(	-LRB-
10_1101-2021_02_13_429885	206	19	9	9	CD
10_1101-2021_02_13_429885	206	20	)	)	-RRB-
10_1101-2021_02_13_429885	206	21	:	:	:
10_1101-2021_02_13_429885	206	22	707–14	707–14	CD
10_1101-2021_02_13_429885	206	23	.	.	.
10_1101-2021_02_13_429885	207	1	https://doi.org/​10.1038/s41592-018-0108-x​.	https://doi.org/​10.1038/s41592-018-0108-x​.	ADD
10_1101-2021_02_13_429885	208	1	Caravagna	Caravagna	NNP
10_1101-2021_02_13_429885	208	2	,	,	,
10_1101-2021_02_13_429885	208	3	Giulio	Giulio	NNP
10_1101-2021_02_13_429885	208	4	,	,	,
10_1101-2021_02_13_429885	208	5	Alex	Alex	NNP
10_1101-2021_02_13_429885	208	6	Graudenzi	Graudenzi	NNP
10_1101-2021_02_13_429885	208	7	,	,	,
10_1101-2021_02_13_429885	208	8	Daniele	Daniele	NNP
10_1101-2021_02_13_429885	208	9	Ramazzotti	Ramazzotti	NNP
10_1101-2021_02_13_429885	208	10	,	,	,
10_1101-2021_02_13_429885	208	11	Rebeca	Rebeca	NNP
10_1101-2021_02_13_429885	208	12	Sanz	Sanz	NNP
10_1101-2021_02_13_429885	208	13	-	-	HYPH
10_1101-2021_02_13_429885	208	14	Pamplona	Pamplona	NNP
10_1101-2021_02_13_429885	208	15	,	,	,
10_1101-2021_02_13_429885	208	16	Luca	Luca	NNP
10_1101-2021_02_13_429885	208	17	De	De	NNP
10_1101-2021_02_13_429885	208	18	Sano	Sano	NNP
10_1101-2021_02_13_429885	208	19	,	,	,
10_1101-2021_02_13_429885	208	20	Giancarlo	Giancarlo	NNP
10_1101-2021_02_13_429885	208	21	Mauri	Mauri	NNP
10_1101-2021_02_13_429885	208	22	,	,	,
10_1101-2021_02_13_429885	208	23	Victor	Victor	NNP
10_1101-2021_02_13_429885	208	24	Moreno	Moreno	NNP
10_1101-2021_02_13_429885	208	25	,	,	,
10_1101-2021_02_13_429885	208	26	Marco	Marco	NNP
10_1101-2021_02_13_429885	208	27	Antoniotti	Antoniotti	NNP
10_1101-2021_02_13_429885	208	28	,	,	,
10_1101-2021_02_13_429885	208	29	and	and	CC
10_1101-2021_02_13_429885	208	30	Bud	Bud	NNP
10_1101-2021_02_13_429885	208	31	Mishra	Mishra	NNP
10_1101-2021_02_13_429885	208	32	.	.	.
10_1101-2021_02_13_429885	209	1	07	07	CD
10_1101-2021_02_13_429885	209	2	12	12	CD
10_1101-2021_02_13_429885	209	3	,	,	,
10_1101-2021_02_13_429885	209	4	2016	2016	CD
10_1101-2021_02_13_429885	209	5	.	.	.
10_1101-2021_02_13_429885	210	1	“	"	``
10_1101-2021_02_13_429885	210	2	Algorithmic	Algorithmic	NNP
10_1101-2021_02_13_429885	210	3	Methods	method	NNS
10_1101-2021_02_13_429885	210	4	to	to	TO
10_1101-2021_02_13_429885	210	5	Infer	infer	VB
10_1101-2021_02_13_429885	210	6	the	the	DT
10_1101-2021_02_13_429885	210	7	Evolutionary	Evolutionary	NNP
10_1101-2021_02_13_429885	210	8	Trajectories	Trajectories	NNPS
10_1101-2021_02_13_429885	210	9	in	in	IN
10_1101-2021_02_13_429885	210	10	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	210	11	Progression	Progression	NNP
10_1101-2021_02_13_429885	210	12	.	.	.
10_1101-2021_02_13_429885	210	13	”	"	''
10_1101-2021_02_13_429885	210	14	Proceedings	proceeding	NNS
10_1101-2021_02_13_429885	210	15	of	of	IN
10_1101-2021_02_13_429885	210	16	the	the	DT
10_1101-2021_02_13_429885	210	17	National	National	NNP
10_1101-2021_02_13_429885	210	18	Academy	Academy	NNP
10_1101-2021_02_13_429885	210	19	of	of	IN
10_1101-2021_02_13_429885	210	20	Sciences	Sciences	NNPS
10_1101-2021_02_13_429885	210	21	of	of	IN
10_1101-2021_02_13_429885	210	22	the	the	DT
10_1101-2021_02_13_429885	210	23	United	United	NNP
10_1101-2021_02_13_429885	210	24	States	States	NNP
10_1101-2021_02_13_429885	210	25	of	of	IN
10_1101-2021_02_13_429885	210	26	America​	America​	NNP
10_1101-2021_02_13_429885	210	27	113	113	CD
10_1101-2021_02_13_429885	210	28	(	(	-LRB-
10_1101-2021_02_13_429885	210	29	28	28	CD
10_1101-2021_02_13_429885	210	30	)	)	-RRB-
10_1101-2021_02_13_429885	210	31	:	:	:
10_1101-2021_02_13_429885	210	32	E4025–34	e4025–34	ADD
10_1101-2021_02_13_429885	210	33	.	.	.
10_1101-2021_02_13_429885	211	1	https://doi.org/​10.1073/pnas.1520213113	https://doi.org/​10.1073/pnas.1520213113	RB
10_1101-2021_02_13_429885	211	2	​.	​.	NNP
10_1101-2021_02_13_429885	212	1	Caravagna	Caravagna	NNP
10_1101-2021_02_13_429885	212	2	,	,	,
10_1101-2021_02_13_429885	212	3	Giulio	Giulio	NNP
10_1101-2021_02_13_429885	212	4	,	,	,
10_1101-2021_02_13_429885	212	5	Timon	Timon	NNP
10_1101-2021_02_13_429885	212	6	Heide	Heide	NNP
10_1101-2021_02_13_429885	212	7	,	,	,
10_1101-2021_02_13_429885	212	8	Marc	Marc	NNP
10_1101-2021_02_13_429885	212	9	J.	J.	NNP
10_1101-2021_02_13_429885	212	10	Williams	Williams	NNP
10_1101-2021_02_13_429885	212	11	,	,	,
10_1101-2021_02_13_429885	212	12	Luis	Luis	NNP
10_1101-2021_02_13_429885	212	13	Zapata	Zapata	NNP
10_1101-2021_02_13_429885	212	14	,	,	,
10_1101-2021_02_13_429885	212	15	Daniel	Daniel	NNP
10_1101-2021_02_13_429885	212	16	Nichol	Nichol	NNP
10_1101-2021_02_13_429885	212	17	,	,	,
10_1101-2021_02_13_429885	212	18	Ketevan	Ketevan	NNP
10_1101-2021_02_13_429885	212	19	Chkhaidze	Chkhaidze	NNP
10_1101-2021_02_13_429885	212	20	,	,	,
10_1101-2021_02_13_429885	212	21	William	William	NNP
10_1101-2021_02_13_429885	212	22	Cross	Cross	NNP
10_1101-2021_02_13_429885	212	23	,	,	,
10_1101-2021_02_13_429885	212	24	et	et	NNP
10_1101-2021_02_13_429885	212	25	al	al	NNP
10_1101-2021_02_13_429885	212	26	.	.	.
10_1101-2021_02_13_429885	213	1	2020	2020	CD
10_1101-2021_02_13_429885	213	2	.	.	.
10_1101-2021_02_13_429885	214	1	“	"	``
10_1101-2021_02_13_429885	214	2	Subclonal	subclonal	JJ
10_1101-2021_02_13_429885	214	3	Reconstruction	reconstruction	NN
10_1101-2021_02_13_429885	214	4	of	of	IN
10_1101-2021_02_13_429885	214	5	Tumors	Tumors	NNPS
10_1101-2021_02_13_429885	214	6	by	by	IN
10_1101-2021_02_13_429885	214	7	Using	use	VBG
10_1101-2021_02_13_429885	214	8	Machine	Machine	NNP
10_1101-2021_02_13_429885	214	9	Learning	Learning	NNP
10_1101-2021_02_13_429885	214	10	and	and	CC
10_1101-2021_02_13_429885	214	11	Population	Population	NNP
10_1101-2021_02_13_429885	214	12	Genetics	Genetics	NNPS
10_1101-2021_02_13_429885	214	13	.	.	.
10_1101-2021_02_13_429885	214	14	”	"	''
10_1101-2021_02_13_429885	214	15	​Nature	​nature	JJ
10_1101-2021_02_13_429885	214	16	Genetics​	genetics​	NN
10_1101-2021_02_13_429885	214	17	52	52	CD
10_1101-2021_02_13_429885	214	18	(	(	-LRB-
10_1101-2021_02_13_429885	214	19	9	9	CD
10_1101-2021_02_13_429885	214	20	)	)	-RRB-
10_1101-2021_02_13_429885	214	21	:	:	:
10_1101-2021_02_13_429885	214	22	898–907	898–907	CD
10_1101-2021_02_13_429885	214	23	.	.	.
10_1101-2021_02_13_429885	215	1	https://doi.org/​10.1038/s41588-020-0675-5	https://doi.org/​10.1038/s41588-020-0675-5	CD
10_1101-2021_02_13_429885	215	2	​.	​.	NNP
10_1101-2021_02_13_429885	216	1	Cmero	Cmero	NNP
10_1101-2021_02_13_429885	216	2	,	,	,
10_1101-2021_02_13_429885	216	3	Marek	Marek	NNP
10_1101-2021_02_13_429885	216	4	,	,	,
10_1101-2021_02_13_429885	216	5	Ke	Ke	NNP
10_1101-2021_02_13_429885	216	6	Yuan	Yuan	NNP
10_1101-2021_02_13_429885	216	7	,	,	,
10_1101-2021_02_13_429885	216	8	Cheng	Cheng	NNP
10_1101-2021_02_13_429885	216	9	Soon	Soon	NNP
10_1101-2021_02_13_429885	216	10	Ong	Ong	NNP
10_1101-2021_02_13_429885	216	11	,	,	,
10_1101-2021_02_13_429885	216	12	Jan	Jan	NNP
10_1101-2021_02_13_429885	216	13	Schröder	Schröder	NNP
10_1101-2021_02_13_429885	216	14	,	,	,
10_1101-2021_02_13_429885	216	15	Niall	Niall	NNP
10_1101-2021_02_13_429885	216	16	M.	M.	NNP
10_1101-2021_02_13_429885	216	17	Corcoran	Corcoran	NNP
10_1101-2021_02_13_429885	216	18	,	,	,
10_1101-2021_02_13_429885	216	19	Tony	Tony	NNP
10_1101-2021_02_13_429885	216	20	Papenfuss	Papenfuss	NNP
10_1101-2021_02_13_429885	216	21	,	,	,
10_1101-2021_02_13_429885	216	22	Christopher	Christopher	NNP
10_1101-2021_02_13_429885	216	23	M.	M.	NNP
10_1101-2021_02_13_429885	216	24	Hovens	Hovens	NNP
10_1101-2021_02_13_429885	216	25	,	,	,
10_1101-2021_02_13_429885	216	26	Florian	Florian	NNP
10_1101-2021_02_13_429885	216	27	Markowetz	Markowetz	NNP
10_1101-2021_02_13_429885	216	28	,	,	,
10_1101-2021_02_13_429885	216	29	and	and	CC
10_1101-2021_02_13_429885	216	30	Geoff	Geoff	NNP
10_1101-2021_02_13_429885	216	31	Macintyre	Macintyre	NNP
10_1101-2021_02_13_429885	216	32	.	.	.
10_1101-2021_02_13_429885	217	1	2020	2020	CD
10_1101-2021_02_13_429885	217	2	.	.	.
10_1101-2021_02_13_429885	218	1	“	"	``
10_1101-2021_02_13_429885	218	2	Inferring	infer	VBG
10_1101-2021_02_13_429885	218	3	Structural	Structural	NNP
10_1101-2021_02_13_429885	218	4	Variant	Variant	NNP
10_1101-2021_02_13_429885	218	5	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	218	6	Cell	Cell	NNP
10_1101-2021_02_13_429885	218	7	Fraction	Fraction	NNP
10_1101-2021_02_13_429885	218	8	.	.	.
10_1101-2021_02_13_429885	218	9	”	"	''
10_1101-2021_02_13_429885	218	10	​Nature	​nature	JJ
10_1101-2021_02_13_429885	218	11	Communications​	communications​	NN
10_1101-2021_02_13_429885	218	12	11	11	CD
10_1101-2021_02_13_429885	218	13	(	(	-LRB-
10_1101-2021_02_13_429885	218	14	1	1	CD
10_1101-2021_02_13_429885	218	15	)	)	-RRB-
10_1101-2021_02_13_429885	218	16	:	:	:
10_1101-2021_02_13_429885	218	17	730	730	CD
10_1101-2021_02_13_429885	218	18	.	.	.
10_1101-2021_02_13_429885	218	19	https://doi.org/​10.1038/s41467-020-14351-8	https://doi.org/​10.1038/s41467-020-14351-8	ADD
10_1101-2021_02_13_429885	218	20	​.	​.	NN
10_1101-2021_02_13_429885	219	1	Cortés	Cortés	NNP
10_1101-2021_02_13_429885	219	2	-	-	HYPH
10_1101-2021_02_13_429885	219	3	Ciriano	Ciriano	NNP
10_1101-2021_02_13_429885	219	4	,	,	,
10_1101-2021_02_13_429885	219	5	Isidro	Isidro	NNP
10_1101-2021_02_13_429885	219	6	,	,	,
10_1101-2021_02_13_429885	219	7	Jake	Jake	NNP
10_1101-2021_02_13_429885	219	8	June	June	NNP
10_1101-2021_02_13_429885	219	9	-	-	HYPH
10_1101-2021_02_13_429885	219	10	Koo	Koo	NNP
10_1101-2021_02_13_429885	219	11	Lee	Lee	NNP
10_1101-2021_02_13_429885	219	12	,	,	,
10_1101-2021_02_13_429885	219	13	Ruibin	Ruibin	NNP
10_1101-2021_02_13_429885	219	14	Xi	Xi	NNP
10_1101-2021_02_13_429885	219	15	,	,	,
10_1101-2021_02_13_429885	219	16	Dhawal	Dhawal	NNP
10_1101-2021_02_13_429885	219	17	Jain	Jain	NNP
10_1101-2021_02_13_429885	219	18	,	,	,
10_1101-2021_02_13_429885	219	19	Youngsook	Youngsook	NNP
10_1101-2021_02_13_429885	219	20	L.	L.	NNP
10_1101-2021_02_13_429885	219	21	Jung	Jung	NNP
10_1101-2021_02_13_429885	219	22	,	,	,
10_1101-2021_02_13_429885	219	23	Lixing	Lixing	NNP
10_1101-2021_02_13_429885	219	24	Yang	Yang	NNP
10_1101-2021_02_13_429885	219	25	,	,	,
10_1101-2021_02_13_429885	219	26	Dmitry	Dmitry	NNP
10_1101-2021_02_13_429885	219	27	Gordenin	Gordenin	NNP
10_1101-2021_02_13_429885	219	28	,	,	,
10_1101-2021_02_13_429885	219	29	et	et	NNP
10_1101-2021_02_13_429885	219	30	al	al	NNP
10_1101-2021_02_13_429885	219	31	.	.	.
10_1101-2021_02_13_429885	220	1	2020	2020	CD
10_1101-2021_02_13_429885	220	2	.	.	.
10_1101-2021_02_13_429885	221	1	“	"	``
10_1101-2021_02_13_429885	221	2	Comprehensive	comprehensive	JJ
10_1101-2021_02_13_429885	221	3	Analysis	Analysis	NNP
10_1101-2021_02_13_429885	221	4	of	of	IN
10_1101-2021_02_13_429885	221	5	Chromothripsis	Chromothripsis	NNP
10_1101-2021_02_13_429885	221	6	in	in	IN
10_1101-2021_02_13_429885	221	7	2,658	2,658	CD
10_1101-2021_02_13_429885	221	8	Human	Human	NNP
10_1101-2021_02_13_429885	221	9	Cancers	Cancers	NNPS
10_1101-2021_02_13_429885	221	10	Using	use	VBG
10_1101-2021_02_13_429885	221	11	Whole	whole	JJ
10_1101-2021_02_13_429885	221	12	-	-	HYPH
10_1101-2021_02_13_429885	221	13	Genome	genome	NN
10_1101-2021_02_13_429885	221	14	Sequencing	sequencing	NN
10_1101-2021_02_13_429885	221	15	.	.	.
10_1101-2021_02_13_429885	221	16	”	"	''
10_1101-2021_02_13_429885	221	17	​Nature	​nature	JJ
10_1101-2021_02_13_429885	221	18	Genetics​	genetics​	NN
10_1101-2021_02_13_429885	221	19	52	52	CD
10_1101-2021_02_13_429885	221	20	(	(	-LRB-
10_1101-2021_02_13_429885	221	21	3	3	CD
10_1101-2021_02_13_429885	221	22	)	)	-RRB-
10_1101-2021_02_13_429885	221	23	:	:	:
10_1101-2021_02_13_429885	221	24	331–41	331–41	CD
10_1101-2021_02_13_429885	221	25	.	.	.
10_1101-2021_02_13_429885	222	1	https://doi.org/​10.1038/s41588-019-0576-7	https://doi.org/​10.1038/s41588-019-0576-7	ADD
10_1101-2021_02_13_429885	222	2	​.	​.	NNP
10_1101-2021_02_13_429885	223	1	Cross	Cross	NNP
10_1101-2021_02_13_429885	223	2	,	,	,
10_1101-2021_02_13_429885	223	3	William	William	NNP
10_1101-2021_02_13_429885	223	4	,	,	,
10_1101-2021_02_13_429885	223	5	Michal	Michal	NNP
10_1101-2021_02_13_429885	223	6	Kovac	Kovac	NNP
10_1101-2021_02_13_429885	223	7	,	,	,
10_1101-2021_02_13_429885	223	8	Ville	Ville	NNP
10_1101-2021_02_13_429885	223	9	Mustonen	Mustonen	NNP
10_1101-2021_02_13_429885	223	10	,	,	,
10_1101-2021_02_13_429885	223	11	Daniel	Daniel	NNP
10_1101-2021_02_13_429885	223	12	Temko	Temko	NNP
10_1101-2021_02_13_429885	223	13	,	,	,
10_1101-2021_02_13_429885	223	14	Hayley	Hayley	NNP
10_1101-2021_02_13_429885	223	15	Davis	Davis	NNP
10_1101-2021_02_13_429885	223	16	,	,	,
10_1101-2021_02_13_429885	223	17	Ann	Ann	NNP
10_1101-2021_02_13_429885	223	18	-	-	HYPH
10_1101-2021_02_13_429885	223	19	Marie	Marie	NNP
10_1101-2021_02_13_429885	223	20	Baker	Baker	NNP
10_1101-2021_02_13_429885	223	21	,	,	,
10_1101-2021_02_13_429885	223	22	Sujata	Sujata	NNP
10_1101-2021_02_13_429885	223	23	Biswas	Biswas	NNP
10_1101-2021_02_13_429885	223	24	,	,	,
10_1101-2021_02_13_429885	223	25	et	et	NNP
10_1101-2021_02_13_429885	223	26	al	al	NNP
10_1101-2021_02_13_429885	223	27	.	.	.
10_1101-2021_02_13_429885	224	1	10	10	CD
10_1101-2021_02_13_429885	224	2	2018	2018	CD
10_1101-2021_02_13_429885	224	3	.	.	.
10_1101-2021_02_13_429885	225	1	“	"	``
10_1101-2021_02_13_429885	225	2	The	the	DT
10_1101-2021_02_13_429885	225	3	Evolutionary	Evolutionary	NNP
10_1101-2021_02_13_429885	225	4	Landscape	Landscape	NNP
10_1101-2021_02_13_429885	225	5	of	of	IN
10_1101-2021_02_13_429885	225	6	Colorectal	Colorectal	NNP
10_1101-2021_02_13_429885	225	7	Tumorigenesis	Tumorigenesis	NNP
10_1101-2021_02_13_429885	225	8	.	.	.
10_1101-2021_02_13_429885	225	9	”	"	''
10_1101-2021_02_13_429885	225	10	Nature	Nature	NNP
10_1101-2021_02_13_429885	225	11	Ecology	Ecology	NNP
10_1101-2021_02_13_429885	225	12	&	&	CC
10_1101-2021_02_13_429885	225	13	Evolution​	Evolution​	NNP
10_1101-2021_02_13_429885	225	14	2	2	CD
10_1101-2021_02_13_429885	225	15	(	(	-LRB-
10_1101-2021_02_13_429885	225	16	10	10	CD
10_1101-2021_02_13_429885	225	17	)	)	-RRB-
10_1101-2021_02_13_429885	225	18	:	:	:
10_1101-2021_02_13_429885	225	19	1661–72	1661–72	CD
10_1101-2021_02_13_429885	225	20	.	.	.
10_1101-2021_02_13_429885	226	1	https://doi.org/​10.1038/s41559-018-0642-z​.	https://doi.org/​10.1038/s41559-018-0642-z​.	LS
10_1101-2021_02_13_429885	227	1	Dentro	Dentro	NNP
10_1101-2021_02_13_429885	227	2	,	,	,
10_1101-2021_02_13_429885	227	3	Stefan	Stefan	NNP
10_1101-2021_02_13_429885	227	4	C.	C.	NNP
10_1101-2021_02_13_429885	227	5	,	,	,
10_1101-2021_02_13_429885	227	6	David	David	NNP
10_1101-2021_02_13_429885	227	7	C.	C.	NNP
10_1101-2021_02_13_429885	227	8	Wedge	Wedge	NNP
10_1101-2021_02_13_429885	227	9	,	,	,
10_1101-2021_02_13_429885	227	10	and	and	CC
10_1101-2021_02_13_429885	227	11	Peter	Peter	NNP
10_1101-2021_02_13_429885	227	12	Van	Van	NNP
10_1101-2021_02_13_429885	227	13	Loo	Loo	NNP
10_1101-2021_02_13_429885	227	14	.	.	.
10_1101-2021_02_13_429885	228	1	2017	2017	CD
10_1101-2021_02_13_429885	228	2	.	.	.
10_1101-2021_02_13_429885	229	1	“	"	``
10_1101-2021_02_13_429885	229	2	Principles	principle	NNS
10_1101-2021_02_13_429885	229	3	of	of	IN
10_1101-2021_02_13_429885	229	4	Reconstructing	reconstruct	VBG
10_1101-2021_02_13_429885	229	5	the	the	DT
10_1101-2021_02_13_429885	229	6	Subclonal	Subclonal	NNP
10_1101-2021_02_13_429885	229	7	Architecture	Architecture	NNP
10_1101-2021_02_13_429885	229	8	of	of	IN
10_1101-2021_02_13_429885	229	9	Cancers	Cancers	NNPS
10_1101-2021_02_13_429885	229	10	.	.	.
10_1101-2021_02_13_429885	229	11	”	"	''
10_1101-2021_02_13_429885	229	12	​Cold	​Cold	NNP
10_1101-2021_02_13_429885	229	13	Spring	Spring	NNP
10_1101-2021_02_13_429885	229	14	Harbor	Harbor	NNP
10_1101-2021_02_13_429885	229	15	Perspectives	Perspectives	NNPS
10_1101-2021_02_13_429885	229	16	in	in	IN
10_1101-2021_02_13_429885	229	17	Medicine​	Medicine​	NNP
10_1101-2021_02_13_429885	229	18	7	7	CD
10_1101-2021_02_13_429885	229	19	(	(	-LRB-
10_1101-2021_02_13_429885	229	20	8)	8)	CD
10_1101-2021_02_13_429885	229	21	.	.	.
10_1101-2021_02_13_429885	230	1	https://doi.org/​10.1101/cshperspect.a026625	https://doi.org/​10.1101/cshperspect.a026625	UH
10_1101-2021_02_13_429885	230	2	​.	​.	JJ
10_1101-2021_02_13_429885	231	1	Ding	Ding	NNP
10_1101-2021_02_13_429885	231	2	,	,	,
10_1101-2021_02_13_429885	231	3	Li	Li	NNP
10_1101-2021_02_13_429885	231	4	,	,	,
10_1101-2021_02_13_429885	231	5	Timothy	Timothy	NNP
10_1101-2021_02_13_429885	231	6	J.	J.	NNP
10_1101-2021_02_13_429885	231	7	Ley	Ley	NNP
10_1101-2021_02_13_429885	231	8	,	,	,
10_1101-2021_02_13_429885	231	9	David	David	NNP
10_1101-2021_02_13_429885	231	10	E.	E.	NNP
10_1101-2021_02_13_429885	231	11	Larson	Larson	NNP
10_1101-2021_02_13_429885	231	12	,	,	,
10_1101-2021_02_13_429885	231	13	Christopher	Christopher	NNP
10_1101-2021_02_13_429885	231	14	A.	a.	NN
10_1101-2021_02_13_429885	231	15	Miller	Miller	NNP
10_1101-2021_02_13_429885	231	16	,	,	,
10_1101-2021_02_13_429885	231	17	Daniel	Daniel	NNP
10_1101-2021_02_13_429885	231	18	C.	C.	NNP
10_1101-2021_02_13_429885	231	19	Koboldt	Koboldt	NNP
10_1101-2021_02_13_429885	231	20	,	,	,
10_1101-2021_02_13_429885	231	21	John	John	NNP
10_1101-2021_02_13_429885	231	22	S.	S.	NNP
10_1101-2021_02_13_429885	231	23	Welch	Welch	NNP
10_1101-2021_02_13_429885	231	24	,	,	,
10_1101-2021_02_13_429885	231	25	Julie	Julie	NNP
10_1101-2021_02_13_429885	231	26	K.	K.	NNP
10_1101-2021_02_13_429885	231	27	Ritchey	Ritchey	NNP
10_1101-2021_02_13_429885	231	28	,	,	,
10_1101-2021_02_13_429885	231	29	et	et	NNP
10_1101-2021_02_13_429885	231	30	al	al	NNP
10_1101-2021_02_13_429885	231	31	.	.	.
10_1101-2021_02_13_429885	232	1	2012	2012	CD
10_1101-2021_02_13_429885	232	2	.	.	.
10_1101-2021_02_13_429885	233	1	“	"	``
10_1101-2021_02_13_429885	233	2	Clonal	Clonal	NNP
10_1101-2021_02_13_429885	233	3	Evolution	Evolution	NNP
10_1101-2021_02_13_429885	233	4	in	in	IN
10_1101-2021_02_13_429885	233	5	Relapsed	Relapsed	NNP
10_1101-2021_02_13_429885	233	6	Acute	Acute	NNP
10_1101-2021_02_13_429885	233	7	Myeloid	Myeloid	NNP
10_1101-2021_02_13_429885	233	8	Leukaemia	Leukaemia	NNP
10_1101-2021_02_13_429885	233	9	Revealed	reveal	VBN
10_1101-2021_02_13_429885	233	10	by	by	IN
10_1101-2021_02_13_429885	233	11	Whole	whole	JJ
10_1101-2021_02_13_429885	233	12	-	-	HYPH
10_1101-2021_02_13_429885	233	13	Genome	genome	NN
10_1101-2021_02_13_429885	233	14	Sequencing	sequencing	NN
10_1101-2021_02_13_429885	233	15	.	.	.
10_1101-2021_02_13_429885	233	16	”	"	''
10_1101-2021_02_13_429885	233	17	​Nature​	​nature​	CD
10_1101-2021_02_13_429885	233	18	481	481	CD
10_1101-2021_02_13_429885	233	19	(	(	-LRB-
10_1101-2021_02_13_429885	233	20	7382	7382	CD
10_1101-2021_02_13_429885	233	21	)	)	-RRB-
10_1101-2021_02_13_429885	233	22	:	:	:
10_1101-2021_02_13_429885	233	23	506–10	506–10	CD
10_1101-2021_02_13_429885	233	24	.	.	.
10_1101-2021_02_13_429885	234	1	https://doi.org/​10.1038/nature10738	https://doi.org/​10.1038/nature10738	NNP
10_1101-2021_02_13_429885	234	2	​.	​.	NNP
10_1101-2021_02_13_429885	235	1	Favero	Favero	NNP
10_1101-2021_02_13_429885	235	2	,	,	,
10_1101-2021_02_13_429885	235	3	F.	F.	NNP
10_1101-2021_02_13_429885	235	4	,	,	,
10_1101-2021_02_13_429885	235	5	T.	T.	NNP
10_1101-2021_02_13_429885	235	6	Joshi	Joshi	NNP
10_1101-2021_02_13_429885	235	7	,	,	,
10_1101-2021_02_13_429885	235	8	A.	A.	NNP
10_1101-2021_02_13_429885	235	9	M.	M.	NNP
10_1101-2021_02_13_429885	235	10	Marquard	Marquard	NNP
10_1101-2021_02_13_429885	235	11	,	,	,
10_1101-2021_02_13_429885	235	12	N.	N.	NNP
10_1101-2021_02_13_429885	235	13	J.	J.	NNP
10_1101-2021_02_13_429885	235	14	Birkbak	Birkbak	NNP
10_1101-2021_02_13_429885	235	15	,	,	,
10_1101-2021_02_13_429885	235	16	M.	M.	NNP
10_1101-2021_02_13_429885	235	17	Krzystanek	Krzystanek	NNP
10_1101-2021_02_13_429885	235	18	,	,	,
10_1101-2021_02_13_429885	235	19	Q.	Q.	NNP
10_1101-2021_02_13_429885	235	20	Li	Li	NNP
10_1101-2021_02_13_429885	235	21	,	,	,
10_1101-2021_02_13_429885	235	22	Z.	Z.	NNP
10_1101-2021_02_13_429885	235	23	Szallasi	Szallasi	NNP
10_1101-2021_02_13_429885	235	24	,	,	,
10_1101-2021_02_13_429885	235	25	and	and	CC
10_1101-2021_02_13_429885	235	26	A.	A.	NNP
10_1101-2021_02_13_429885	235	27	C.	C.	NNP
10_1101-2021_02_13_429885	235	28	Eklund	Eklund	NNP
10_1101-2021_02_13_429885	235	29	.	.	.
10_1101-2021_02_13_429885	236	1	2015	2015	CD
10_1101-2021_02_13_429885	236	2	.	.	.
10_1101-2021_02_13_429885	237	1	“	"	``
10_1101-2021_02_13_429885	237	2	Sequenza	sequenza	NN
10_1101-2021_02_13_429885	237	3	:	:	:
10_1101-2021_02_13_429885	237	4	Allele	Allele	NNP
10_1101-2021_02_13_429885	237	5	-	-	HYPH
10_1101-2021_02_13_429885	237	6	Specific	Specific	NNP
10_1101-2021_02_13_429885	237	7	Copy	Copy	NNP
10_1101-2021_02_13_429885	237	8	Number	number	NN
10_1101-2021_02_13_429885	237	9	and	and	CC
10_1101-2021_02_13_429885	237	10	Mutation	Mutation	NNP
10_1101-2021_02_13_429885	237	11	Profiles	Profiles	NNPS
10_1101-2021_02_13_429885	237	12	from	from	IN
10_1101-2021_02_13_429885	237	13	Tumor	Tumor	NNP
10_1101-2021_02_13_429885	237	14	Sequencing	Sequencing	NNP
10_1101-2021_02_13_429885	237	15	Data	Data	NNPS
10_1101-2021_02_13_429885	237	16	.	.	.
10_1101-2021_02_13_429885	237	17	”	"	''
10_1101-2021_02_13_429885	237	18	​Annals	​annal	NNS
10_1101-2021_02_13_429885	237	19	of	of	IN
10_1101-2021_02_13_429885	237	20	Oncology	Oncology	NNP
10_1101-2021_02_13_429885	237	21	:	:	:
10_1101-2021_02_13_429885	237	22	Official	Official	NNP
10_1101-2021_02_13_429885	237	23	Journal	Journal	NNP
10_1101-2021_02_13_429885	237	24	of	of	IN
10_1101-2021_02_13_429885	237	25	the	the	DT
10_1101-2021_02_13_429885	237	26	European	European	NNP
10_1101-2021_02_13_429885	237	27	Society	Society	NNP
10_1101-2021_02_13_429885	237	28	for	for	IN
10_1101-2021_02_13_429885	237	29	Medical	Medical	NNP
10_1101-2021_02_13_429885	237	30	Oncology	Oncology	NNP
10_1101-2021_02_13_429885	237	31	/	/	SYM
10_1101-2021_02_13_429885	237	32	ESMO​	ESMO​	NNP
10_1101-2021_02_13_429885	237	33	26	26	CD
10_1101-2021_02_13_429885	237	34	(	(	-LRB-
10_1101-2021_02_13_429885	237	35	1	1	CD
10_1101-2021_02_13_429885	237	36	)	)	-RRB-
10_1101-2021_02_13_429885	237	37	:	:	:
10_1101-2021_02_13_429885	237	38	64–70	64–70	LS
10_1101-2021_02_13_429885	237	39	.	.	.
10_1101-2021_02_13_429885	238	1	https://doi.org/​10.1093/annonc/mdu479	https://doi.org/​10.1093/annonc/mdu479	PRP
10_1101-2021_02_13_429885	238	2	​.	​.	NNP
10_1101-2021_02_13_429885	239	1	Fischer	Fischer	NNP
10_1101-2021_02_13_429885	239	2	,	,	,
10_1101-2021_02_13_429885	239	3	Andrej	Andrej	NNP
10_1101-2021_02_13_429885	239	4	,	,	,
10_1101-2021_02_13_429885	239	5	Ignacio	Ignacio	NNP
10_1101-2021_02_13_429885	239	6	Vázquez	Vázquez	NNP
10_1101-2021_02_13_429885	239	7	-	-	HYPH
10_1101-2021_02_13_429885	239	8	García	García	NNP
10_1101-2021_02_13_429885	239	9	,	,	,
10_1101-2021_02_13_429885	239	10	Christopher	Christopher	NNP
10_1101-2021_02_13_429885	239	11	J.	J.	NNP
10_1101-2021_02_13_429885	239	12	R.	R.	NNP
10_1101-2021_02_13_429885	239	13	Illingworth	Illingworth	NNP
10_1101-2021_02_13_429885	239	14	,	,	,
10_1101-2021_02_13_429885	239	15	and	and	CC
10_1101-2021_02_13_429885	239	16	Ville	Ville	NNP
10_1101-2021_02_13_429885	239	17	Mustonen	Mustonen	NNP
10_1101-2021_02_13_429885	239	18	.	.	.
10_1101-2021_02_13_429885	240	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	240	2	-	-	:
10_1101-2021_02_13_429885	240	3	BY	by	IN
10_1101-2021_02_13_429885	240	4	-	-	HYPH
10_1101-2021_02_13_429885	240	5	NC	NC	NNP
10_1101-2021_02_13_429885	240	6	-	-	HYPH
10_1101-2021_02_13_429885	240	7	ND	ND	NNP
10_1101-2021_02_13_429885	240	8	4.0	4.0	CD
10_1101-2021_02_13_429885	240	9	International	International	NNP
10_1101-2021_02_13_429885	240	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	240	11	under	under	IN
10_1101-2021_02_13_429885	240	12	a	a	DT
10_1101-2021_02_13_429885	240	13	(	(	-LRB-
10_1101-2021_02_13_429885	240	14	which	which	WDT
10_1101-2021_02_13_429885	240	15	was	be	VBD
10_1101-2021_02_13_429885	240	16	not	not	RB
10_1101-2021_02_13_429885	240	17	certified	certify	VBN
10_1101-2021_02_13_429885	240	18	by	by	IN
10_1101-2021_02_13_429885	240	19	peer	peer	NN
10_1101-2021_02_13_429885	240	20	review	review	NN
10_1101-2021_02_13_429885	240	21	)	)	-RRB-
10_1101-2021_02_13_429885	240	22	is	be	VBZ
10_1101-2021_02_13_429885	240	23	the	the	DT
10_1101-2021_02_13_429885	240	24	author	author	NN
10_1101-2021_02_13_429885	240	25	/	/	SYM
10_1101-2021_02_13_429885	240	26	funder	funder	NN
10_1101-2021_02_13_429885	240	27	,	,	,
10_1101-2021_02_13_429885	240	28	who	who	WP
10_1101-2021_02_13_429885	240	29	has	have	VBZ
10_1101-2021_02_13_429885	240	30	granted	grant	VBN
10_1101-2021_02_13_429885	240	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	240	32	a	a	DT
10_1101-2021_02_13_429885	240	33	license	license	NN
10_1101-2021_02_13_429885	240	34	to	to	TO
10_1101-2021_02_13_429885	240	35	display	display	VB
10_1101-2021_02_13_429885	240	36	the	the	DT
10_1101-2021_02_13_429885	240	37	preprint	preprint	NN
10_1101-2021_02_13_429885	240	38	in	in	IN
10_1101-2021_02_13_429885	240	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	240	40	.	.	.
10_1101-2021_02_13_429885	241	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	241	2	is	be	VBZ
10_1101-2021_02_13_429885	241	3	made	make	VBN
10_1101-2021_02_13_429885	241	4	The	the	DT
10_1101-2021_02_13_429885	241	5	copyright	copyright	NN
10_1101-2021_02_13_429885	241	6	holder	holder	NN
10_1101-2021_02_13_429885	241	7	for	for	IN
10_1101-2021_02_13_429885	241	8	this	this	DT
10_1101-2021_02_13_429885	241	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	241	10	version	version	NN
10_1101-2021_02_13_429885	241	11	posted	post	VBD
10_1101-2021_02_13_429885	241	12	February	February	NNP
10_1101-2021_02_13_429885	241	13	13	13	CD
10_1101-2021_02_13_429885	241	14	,	,	,
10_1101-2021_02_13_429885	241	15	2021	2021	CD
10_1101-2021_02_13_429885	241	16	.	.	.
10_1101-2021_02_13_429885	241	17	;	;	:
10_1101-2021_02_13_429885	241	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	241	19	:	:	:
10_1101-2021_02_13_429885	241	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	241	21	preprint	preprint	NN
10_1101-2021_02_13_429885	241	22	http://paperpile.com/b/rqVmzs/j5j7	http://paperpile.com/b/rqVmzs/j5j7	VBZ
10_1101-2021_02_13_429885	241	23	http://paperpile.com/b/rqVmzs/j5j7	http://paperpile.com/b/rqVmzs/j5j7	NNS
10_1101-2021_02_13_429885	241	24	http://paperpile.com/b/rqVmzs/j5j7	http://paperpile.com/b/rqvmzs/j5j7	CD
10_1101-2021_02_13_429885	241	25	http://dx.doi.org/10.1038/s41436-018-0278-z	http://dx.doi.org/10.1038/s41436-018-0278-z	NNP
10_1101-2021_02_13_429885	241	26	http://paperpile.com/b/rqVmzs/j5j7	http://paperpile.com/b/rqVmzs/j5j7	NNS
10_1101-2021_02_13_429885	241	27	http://paperpile.com/b/rqVmzs/bD5o	http://paperpile.com/b/rqVmzs/bD5o	NNP
10_1101-2021_02_13_429885	241	28	http://paperpile.com/b/rqVmzs/bD5o	http://paperpile.com/b/rqVmzs/bD5o	NNP
10_1101-2021_02_13_429885	241	29	http://paperpile.com/b/rqVmzs/bD5o	http://paperpile.com/b/rqVmzs/bD5o	NNP
10_1101-2021_02_13_429885	241	30	http://paperpile.com/b/rqVmzs/bD5o	http://paperpile.com/b/rqVmzs/bD5o	NNP
10_1101-2021_02_13_429885	241	31	http://paperpile.com/b/rqVmzs/bD5o	http://paperpile.com/b/rqVmzs/bD5o	NNP
10_1101-2021_02_13_429885	241	32	http://dx.doi.org/10.1101/861054	http://dx.doi.org/10.1101/861054	NNP
10_1101-2021_02_13_429885	241	33	http://paperpile.com/b/rqVmzs/bD5o	http://paperpile.com/b/rqVmzs/bD5o	NNP
10_1101-2021_02_13_429885	241	34	http://paperpile.com/b/rqVmzs/IX1R	http://paperpile.com/b/rqVmzs/IX1R	NNP
10_1101-2021_02_13_429885	241	35	http://paperpile.com/b/rqVmzs/IX1R	http://paperpile.com/b/rqVmzs/IX1R	NNP
10_1101-2021_02_13_429885	241	36	http://paperpile.com/b/rqVmzs/IX1R	http://paperpile.com/b/rqVmzs/IX1R	NNP
10_1101-2021_02_13_429885	241	37	http://paperpile.com/b/rqVmzs/IX1R	http://paperpile.com/b/rqVmzs/IX1R	NNP
10_1101-2021_02_13_429885	241	38	http://paperpile.com/b/rqVmzs/IX1R	http://paperpile.com/b/rqVmzs/IX1R	NNP
10_1101-2021_02_13_429885	241	39	http://dx.doi.org/10.1093/bioinformatics/btq635	http://dx.doi.org/10.1093/bioinformatics/btq635	NNP
10_1101-2021_02_13_429885	241	40	http://paperpile.com/b/rqVmzs/IX1R	http://paperpile.com/b/rqVmzs/IX1R	NNP
10_1101-2021_02_13_429885	241	41	http://paperpile.com/b/rqVmzs/CxXa	http://paperpile.com/b/rqVmzs/CxXa	NNP
10_1101-2021_02_13_429885	241	42	http://paperpile.com/b/rqVmzs/CxXa	http://paperpile.com/b/rqVmzs/CxXa	NNP
10_1101-2021_02_13_429885	241	43	http://paperpile.com/b/rqVmzs/CxXa	http://paperpile.com/b/rqVmzs/CxXa	NNP
10_1101-2021_02_13_429885	241	44	http://paperpile.com/b/rqVmzs/CxXa	http://paperpile.com/b/rqVmzs/CxXa	NNP
10_1101-2021_02_13_429885	241	45	http://paperpile.com/b/rqVmzs/CxXa	http://paperpile.com/b/rqVmzs/CxXa	NNP
10_1101-2021_02_13_429885	241	46	http://dx.doi.org/10.1038/s41586-020-1969-6	http://dx.doi.org/10.1038/s41586-020-1969-6	NNP
10_1101-2021_02_13_429885	241	47	http://paperpile.com/b/rqVmzs/CxXa	http://paperpile.com/b/rqvmzs/cxxa	CD
10_1101-2021_02_13_429885	241	48	http://paperpile.com/b/rqVmzs/eR0S	http://paperpile.com/b/rqVmzs/eR0S	NNP
10_1101-2021_02_13_429885	241	49	http://paperpile.com/b/rqVmzs/eR0S	http://paperpile.com/b/rqVmzs/eR0S	NNP
10_1101-2021_02_13_429885	241	50	http://paperpile.com/b/rqVmzs/eR0S	http://paperpile.com/b/rqvmzs/er0s	NN
10_1101-2021_02_13_429885	241	51	http://paperpile.com/b/rqVmzs/eR0S	http://paperpile.com/b/rqvmzs/er0s	NN
10_1101-2021_02_13_429885	241	52	http://paperpile.com/b/rqVmzs/eR0S	http://paperpile.com/b/rqVmzs/eR0S	NNP
10_1101-2021_02_13_429885	241	53	http://paperpile.com/b/rqVmzs/eR0S	http://paperpile.com/b/rqvmzs/er0s	NN
10_1101-2021_02_13_429885	241	54	http://dx.doi.org/10.1038/s41592-018-0108-x	http://dx.doi.org/10.1038/s41592-018-0108-x	VBZ
10_1101-2021_02_13_429885	241	55	http://paperpile.com/b/rqVmzs/eR0S	http://paperpile.com/b/rqVmzs/eR0S	NNP
10_1101-2021_02_13_429885	241	56	http://paperpile.com/b/rqVmzs/Rl5f	http://paperpile.com/b/rqVmzs/Rl5f	NNP
10_1101-2021_02_13_429885	241	57	http://paperpile.com/b/rqVmzs/Rl5f	http://paperpile.com/b/rqVmzs/Rl5f	NNP
10_1101-2021_02_13_429885	241	58	http://paperpile.com/b/rqVmzs/Rl5f	http://paperpile.com/b/rqVmzs/Rl5f	NNP
10_1101-2021_02_13_429885	241	59	http://paperpile.com/b/rqVmzs/Rl5f	http://paperpile.com/b/rqVmzs/Rl5f	NNP
10_1101-2021_02_13_429885	241	60	http://paperpile.com/b/rqVmzs/Rl5f	http://paperpile.com/b/rqVmzs/Rl5f	NNP
10_1101-2021_02_13_429885	241	61	http://paperpile.com/b/rqVmzs/Rl5f	http://paperpile.com/b/rqVmzs/Rl5f	NNP
10_1101-2021_02_13_429885	241	62	http://dx.doi.org/10.1073/pnas.1520213113	http://dx.doi.org/10.1073/pnas.1520213113	NN
10_1101-2021_02_13_429885	241	63	http://paperpile.com/b/rqVmzs/Rl5f	http://paperpile.com/b/rqVmzs/Rl5f	NNP
10_1101-2021_02_13_429885	241	64	http://paperpile.com/b/rqVmzs/chqB	http://paperpile.com/b/rqVmzs/chqB	NNP
10_1101-2021_02_13_429885	241	65	http://paperpile.com/b/rqVmzs/chqB	http://paperpile.com/b/rqVmzs/chqB	NNP
10_1101-2021_02_13_429885	241	66	http://paperpile.com/b/rqVmzs/chqB	http://paperpile.com/b/rqVmzs/chqB	NNP
10_1101-2021_02_13_429885	241	67	http://paperpile.com/b/rqVmzs/chqB	http://paperpile.com/b/rqVmzs/chqB	NNP
10_1101-2021_02_13_429885	241	68	http://paperpile.com/b/rqVmzs/chqB	http://paperpile.com/b/rqVmzs/chqB	NNP
10_1101-2021_02_13_429885	241	69	http://paperpile.com/b/rqVmzs/chqB	http://paperpile.com/b/rqVmzs/chqB	NNP
10_1101-2021_02_13_429885	241	70	http://dx.doi.org/10.1038/s41588-020-0675-5	http://dx.doi.org/10.1038/s41588-020-0675-5	NN
10_1101-2021_02_13_429885	241	71	http://paperpile.com/b/rqVmzs/chqB	http://paperpile.com/b/rqVmzs/chqB	NNP
10_1101-2021_02_13_429885	241	72	http://paperpile.com/b/rqVmzs/ydMa	http://paperpile.com/b/rqvmzs/ydma	NN
10_1101-2021_02_13_429885	241	73	http://paperpile.com/b/rqVmzs/ydMa	http://paperpile.com/b/rqvmzs/ydma	PRP
10_1101-2021_02_13_429885	241	74	http://paperpile.com/b/rqVmzs/ydMa	http://paperpile.com/b/rqvmzs/ydma	NN
10_1101-2021_02_13_429885	241	75	http://paperpile.com/b/rqVmzs/ydMa	http://paperpile.com/b/rqVmzs/ydMa	NNP
10_1101-2021_02_13_429885	241	76	http://paperpile.com/b/rqVmzs/ydMa	http://paperpile.com/b/rqVmzs/ydMa	NNP
10_1101-2021_02_13_429885	241	77	http://paperpile.com/b/rqVmzs/ydMa	http://paperpile.com/b/rqVmzs/ydMa	NNP
10_1101-2021_02_13_429885	241	78	http://dx.doi.org/10.1038/s41467-020-14351-8	http://dx.doi.org/10.1038/s41467-020-14351-8	NNP
10_1101-2021_02_13_429885	241	79	http://paperpile.com/b/rqVmzs/ydMa	http://paperpile.com/b/rqVmzs/ydMa	NNP
10_1101-2021_02_13_429885	241	80	http://paperpile.com/b/rqVmzs/FjZP	http://paperpile.com/b/rqvmzs/fjzp	ADD
10_1101-2021_02_13_429885	241	81	http://paperpile.com/b/rqVmzs/FjZP	http://paperpile.com/b/rqvmzs/fjzp	ADD
10_1101-2021_02_13_429885	241	82	http://paperpile.com/b/rqVmzs/FjZP	http://paperpile.com/b/rqvmzs/fjzp	ADD
10_1101-2021_02_13_429885	241	83	http://paperpile.com/b/rqVmzs/FjZP	http://paperpile.com/b/rqvmzs/fjzp	ADD
10_1101-2021_02_13_429885	241	84	http://paperpile.com/b/rqVmzs/FjZP	http://paperpile.com/b/rqvmzs/fjzp	ADD
10_1101-2021_02_13_429885	241	85	http://paperpile.com/b/rqVmzs/FjZP	http://paperpile.com/b/rqvmzs/fjzp	UH
10_1101-2021_02_13_429885	241	86	http://dx.doi.org/10.1038/s41588-019-0576-7	http://dx.doi.org/10.1038/s41588-019-0576-7	NNP
10_1101-2021_02_13_429885	241	87	http://paperpile.com/b/rqVmzs/FjZP	http://paperpile.com/b/rqVmzs/FjZP	NNP
10_1101-2021_02_13_429885	241	88	http://paperpile.com/b/rqVmzs/IC0y	http://paperpile.com/b/rqVmzs/IC0y	NNP
10_1101-2021_02_13_429885	241	89	http://paperpile.com/b/rqVmzs/IC0y	http://paperpile.com/b/rqVmzs/IC0y	NNP
10_1101-2021_02_13_429885	241	90	http://paperpile.com/b/rqVmzs/IC0y	http://paperpile.com/b/rqVmzs/IC0y	NNP
10_1101-2021_02_13_429885	241	91	http://paperpile.com/b/rqVmzs/IC0y	http://paperpile.com/b/rqVmzs/IC0y	NNP
10_1101-2021_02_13_429885	241	92	http://dx.doi.org/10.1038/s41559-018-0642-z	http://dx.doi.org/10.1038/s41559-018-0642-z	NNP
10_1101-2021_02_13_429885	241	93	http://paperpile.com/b/rqVmzs/IC0y	http://paperpile.com/b/rqVmzs/IC0y	NNP
10_1101-2021_02_13_429885	241	94	http://paperpile.com/b/rqVmzs/Uxwc	http://paperpile.com/b/rqVmzs/Uxwc	NNP
10_1101-2021_02_13_429885	241	95	http://paperpile.com/b/rqVmzs/Uxwc	http://paperpile.com/b/rqvmzs/uxwc	JJ
10_1101-2021_02_13_429885	241	96	http://paperpile.com/b/rqVmzs/Uxwc	http://paperpile.com/b/rqVmzs/Uxwc	NNP
10_1101-2021_02_13_429885	241	97	http://paperpile.com/b/rqVmzs/Uxwc	http://paperpile.com/b/rqvmzs/uxwc	JJ
10_1101-2021_02_13_429885	241	98	http://paperpile.com/b/rqVmzs/Uxwc	http://paperpile.com/b/rqVmzs/Uxwc	NNP
10_1101-2021_02_13_429885	241	99	http://dx.doi.org/10.1101/cshperspect.a026625	http://dx.doi.org/10.1101/cshperspect.a026625	NNP
10_1101-2021_02_13_429885	241	100	http://paperpile.com/b/rqVmzs/Uxwc	http://paperpile.com/b/rqVmzs/Uxwc	NNP
10_1101-2021_02_13_429885	241	101	http://paperpile.com/b/rqVmzs/wPG3	http://paperpile.com/b/rqvmzs/wpg3	CD
10_1101-2021_02_13_429885	241	102	http://paperpile.com/b/rqVmzs/wPG3	http://paperpile.com/b/rqvmzs/wpg3	CD
10_1101-2021_02_13_429885	241	103	http://paperpile.com/b/rqVmzs/wPG3	http://paperpile.com/b/rqvmzs/wpg3	CD
10_1101-2021_02_13_429885	241	104	http://paperpile.com/b/rqVmzs/wPG3	http://paperpile.com/b/rqvmzs/wpg3	CD
10_1101-2021_02_13_429885	241	105	http://paperpile.com/b/rqVmzs/wPG3	http://paperpile.com/b/rqvmzs/wpg3	CD
10_1101-2021_02_13_429885	241	106	http://paperpile.com/b/rqVmzs/wPG3	http://paperpile.com/b/rqvmzs/wpg3	CD
10_1101-2021_02_13_429885	241	107	http://dx.doi.org/10.1038/nature10738	http://dx.doi.org/10.1038/nature10738	NNP
10_1101-2021_02_13_429885	241	108	http://paperpile.com/b/rqVmzs/wPG3	http://paperpile.com/b/rqvmzs/wpg3	CD
10_1101-2021_02_13_429885	241	109	http://paperpile.com/b/rqVmzs/tCb6	http://paperpile.com/b/rqvmzs/tcb6	UH
10_1101-2021_02_13_429885	241	110	http://paperpile.com/b/rqVmzs/tCb6	http://paperpile.com/b/rqvmzs/tcb6	UH
10_1101-2021_02_13_429885	241	111	http://paperpile.com/b/rqVmzs/tCb6	http://paperpile.com/b/rqvmzs/tcb6	UH
10_1101-2021_02_13_429885	241	112	http://paperpile.com/b/rqVmzs/tCb6	http://paperpile.com/b/rqvmzs/tcb6	UH
10_1101-2021_02_13_429885	241	113	http://paperpile.com/b/rqVmzs/tCb6	http://paperpile.com/b/rqvmzs/tcb6	UH
10_1101-2021_02_13_429885	241	114	http://paperpile.com/b/rqVmzs/tCb6	http://paperpile.com/b/rqVmzs/tCb6	NNP
10_1101-2021_02_13_429885	241	115	http://dx.doi.org/10.1093/annonc/mdu479	http://dx.doi.org/10.1093/annonc/mdu479	NNP
10_1101-2021_02_13_429885	241	116	http://paperpile.com/b/rqVmzs/tCb6	http://paperpile.com/b/rqVmzs/tCb6	NNP
10_1101-2021_02_13_429885	241	117	http://paperpile.com/b/rqVmzs/A7Vg	http://paperpile.com/b/rqVmzs/A7Vg	NNP
10_1101-2021_02_13_429885	241	118	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	241	119	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	241	120	Househam	Househam	NNP
10_1101-2021_02_13_429885	241	121	et	et	FW
10_1101-2021_02_13_429885	241	122	al	al	NNP
10_1101-2021_02_13_429885	241	123	.	.	.
10_1101-2021_02_13_429885	242	1	A	a	DT
10_1101-2021_02_13_429885	242	2	fully	fully	RB
10_1101-2021_02_13_429885	242	3	automated	automate	VBN
10_1101-2021_02_13_429885	242	4	approach	approach	NN
10_1101-2021_02_13_429885	242	5	for	for	IN
10_1101-2021_02_13_429885	242	6	quality	quality	NN
10_1101-2021_02_13_429885	242	7	control	control	NN
10_1101-2021_02_13_429885	242	8	of	of	IN
10_1101-2021_02_13_429885	242	9	cancer	cancer	NN
10_1101-2021_02_13_429885	242	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	242	11	in	in	IN
10_1101-2021_02_13_429885	242	12	the	the	DT
10_1101-2021_02_13_429885	242	13	era	era	NN
10_1101-2021_02_13_429885	242	14	of	of	IN
10_1101-2021_02_13_429885	242	15	high	high	JJ
10_1101-2021_02_13_429885	242	16	-	-	HYPH
10_1101-2021_02_13_429885	242	17	resolution	resolution	NN
10_1101-2021_02_13_429885	242	18	whole	whole	JJ
10_1101-2021_02_13_429885	242	19	genome	genome	JJ
10_1101-2021_02_13_429885	242	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	242	21	.	.	.
10_1101-2021_02_13_429885	243	1	2014	2014	CD
10_1101-2021_02_13_429885	243	2	.	.	.
10_1101-2021_02_13_429885	244	1	“	"	``
10_1101-2021_02_13_429885	244	2	High	High	NNP
10_1101-2021_02_13_429885	244	3	-	-	HYPH
10_1101-2021_02_13_429885	244	4	Definition	Definition	NNP
10_1101-2021_02_13_429885	244	5	Reconstruction	Reconstruction	NNP
10_1101-2021_02_13_429885	244	6	of	of	IN
10_1101-2021_02_13_429885	244	7	Clonal	Clonal	NNP
10_1101-2021_02_13_429885	244	8	Composition	Composition	NNP
10_1101-2021_02_13_429885	244	9	in	in	IN
10_1101-2021_02_13_429885	244	10	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	244	11	.	.	.
10_1101-2021_02_13_429885	244	12	”	"	''
10_1101-2021_02_13_429885	244	13	​Cell	​Cell	NNP
10_1101-2021_02_13_429885	244	14	Reports​	Reports​	NNP
10_1101-2021_02_13_429885	244	15	7	7	CD
10_1101-2021_02_13_429885	244	16	(	(	-LRB-
10_1101-2021_02_13_429885	244	17	5	5	CD
10_1101-2021_02_13_429885	244	18	)	)	-RRB-
10_1101-2021_02_13_429885	244	19	:	:	:
10_1101-2021_02_13_429885	244	20	1740–52	1740–52	LS
10_1101-2021_02_13_429885	244	21	.	.	.
10_1101-2021_02_13_429885	245	1	https://doi.org/​10.1016/j.celrep.2014.04.055	https://doi.org/​10.1016/j.celrep.2014.04.055	NNP
10_1101-2021_02_13_429885	245	2	​.	​.	NNP
10_1101-2021_02_13_429885	246	1	Gerstung	Gerstung	NNP
10_1101-2021_02_13_429885	246	2	,	,	,
10_1101-2021_02_13_429885	246	3	Moritz	Moritz	NNP
10_1101-2021_02_13_429885	246	4	,	,	,
10_1101-2021_02_13_429885	246	5	Clemency	Clemency	NNP
10_1101-2021_02_13_429885	246	6	Jolly	Jolly	NNP
10_1101-2021_02_13_429885	246	7	,	,	,
10_1101-2021_02_13_429885	246	8	Ignaty	Ignaty	NNP
10_1101-2021_02_13_429885	246	9	Leshchiner	Leshchiner	NNP
10_1101-2021_02_13_429885	246	10	,	,	,
10_1101-2021_02_13_429885	246	11	Stefan	Stefan	NNP
10_1101-2021_02_13_429885	246	12	C.	C.	NNP
10_1101-2021_02_13_429885	246	13	Dentro	Dentro	NNP
10_1101-2021_02_13_429885	246	14	,	,	,
10_1101-2021_02_13_429885	246	15	Santiago	Santiago	NNP
10_1101-2021_02_13_429885	246	16	Gonzalez	Gonzalez	NNP
10_1101-2021_02_13_429885	246	17	,	,	,
10_1101-2021_02_13_429885	246	18	Daniel	Daniel	NNP
10_1101-2021_02_13_429885	246	19	Rosebrock	Rosebrock	NNP
10_1101-2021_02_13_429885	246	20	,	,	,
10_1101-2021_02_13_429885	246	21	Thomas	Thomas	NNP
10_1101-2021_02_13_429885	246	22	J.	J.	NNP
10_1101-2021_02_13_429885	246	23	Mitchell	Mitchell	NNP
10_1101-2021_02_13_429885	246	24	,	,	,
10_1101-2021_02_13_429885	246	25	et	et	NNP
10_1101-2021_02_13_429885	246	26	al	al	NNP
10_1101-2021_02_13_429885	246	27	.	.	.
10_1101-2021_02_13_429885	247	1	2020	2020	CD
10_1101-2021_02_13_429885	247	2	.	.	.
10_1101-2021_02_13_429885	248	1	“	"	``
10_1101-2021_02_13_429885	248	2	The	the	DT
10_1101-2021_02_13_429885	248	3	Evolutionary	Evolutionary	NNP
10_1101-2021_02_13_429885	248	4	History	history	NN
10_1101-2021_02_13_429885	248	5	of	of	IN
10_1101-2021_02_13_429885	248	6	2,658	2,658	CD
10_1101-2021_02_13_429885	248	7	Cancers	Cancers	NNPS
10_1101-2021_02_13_429885	248	8	.	.	.
10_1101-2021_02_13_429885	248	9	”	"	''
10_1101-2021_02_13_429885	248	10	​Nature​	​Nature​	NNP
10_1101-2021_02_13_429885	248	11	578	578	CD
10_1101-2021_02_13_429885	248	12	(	(	-LRB-
10_1101-2021_02_13_429885	248	13	7793	7793	CD
10_1101-2021_02_13_429885	248	14	)	)	-RRB-
10_1101-2021_02_13_429885	248	15	:	:	:
10_1101-2021_02_13_429885	248	16	122–28	122–28	CD
10_1101-2021_02_13_429885	248	17	.	.	.
10_1101-2021_02_13_429885	249	1	https://doi.org/​10.1038/s41586-019-1907-7	https://doi.org/​10.1038/s41586-019-1907-7	NNP
10_1101-2021_02_13_429885	249	2	​.	​.	NNP
10_1101-2021_02_13_429885	250	1	Gonzalez	Gonzalez	NNP
10_1101-2021_02_13_429885	250	2	-	-	HYPH
10_1101-2021_02_13_429885	250	3	Perez	Perez	NNP
10_1101-2021_02_13_429885	250	4	,	,	,
10_1101-2021_02_13_429885	250	5	Abel	Abel	NNP
10_1101-2021_02_13_429885	250	6	,	,	,
10_1101-2021_02_13_429885	250	7	Christian	Christian	NNP
10_1101-2021_02_13_429885	250	8	Perez	Perez	NNP
10_1101-2021_02_13_429885	250	9	-	-	HYPH
10_1101-2021_02_13_429885	250	10	Llamas	Llamas	NNP
10_1101-2021_02_13_429885	250	11	,	,	,
10_1101-2021_02_13_429885	250	12	Jordi	Jordi	NNP
10_1101-2021_02_13_429885	250	13	Deu	Deu	NNP
10_1101-2021_02_13_429885	250	14	-	-	HYPH
10_1101-2021_02_13_429885	250	15	Pons	Pons	NNP
10_1101-2021_02_13_429885	250	16	,	,	,
10_1101-2021_02_13_429885	250	17	David	David	NNP
10_1101-2021_02_13_429885	250	18	Tamborero	Tamborero	NNP
10_1101-2021_02_13_429885	250	19	,	,	,
10_1101-2021_02_13_429885	250	20	Michael	Michael	NNP
10_1101-2021_02_13_429885	250	21	P.	P.	NNP
10_1101-2021_02_13_429885	250	22	Schroeder	Schroeder	NNP
10_1101-2021_02_13_429885	250	23	,	,	,
10_1101-2021_02_13_429885	250	24	Alba	Alba	NNP
10_1101-2021_02_13_429885	250	25	Jene	Jene	NNP
10_1101-2021_02_13_429885	250	26	-	-	HYPH
10_1101-2021_02_13_429885	250	27	Sanz	Sanz	NNP
10_1101-2021_02_13_429885	250	28	,	,	,
10_1101-2021_02_13_429885	250	29	Alberto	Alberto	NNP
10_1101-2021_02_13_429885	250	30	Santos	Santos	NNP
10_1101-2021_02_13_429885	250	31	,	,	,
10_1101-2021_02_13_429885	250	32	and	and	CC
10_1101-2021_02_13_429885	250	33	Nuria	Nuria	NNP
10_1101-2021_02_13_429885	250	34	Lopez	Lopez	NNP
10_1101-2021_02_13_429885	250	35	-	-	HYPH
10_1101-2021_02_13_429885	250	36	Bigas	Bigas	NNP
10_1101-2021_02_13_429885	250	37	.	.	.
10_1101-2021_02_13_429885	251	1	2013	2013	CD
10_1101-2021_02_13_429885	251	2	.	.	.
10_1101-2021_02_13_429885	252	1	“	"	``
10_1101-2021_02_13_429885	252	2	IntOGen	IntOGen	NNP
10_1101-2021_02_13_429885	252	3	-	-	HYPH
10_1101-2021_02_13_429885	252	4	Mutations	Mutations	NNP
10_1101-2021_02_13_429885	252	5	Identifies	Identifies	NNPS
10_1101-2021_02_13_429885	252	6	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	252	7	Drivers	Drivers	NNPS
10_1101-2021_02_13_429885	252	8	across	across	IN
10_1101-2021_02_13_429885	252	9	Tumor	Tumor	NNP
10_1101-2021_02_13_429885	252	10	Types	Types	NNP
10_1101-2021_02_13_429885	252	11	.	.	.
10_1101-2021_02_13_429885	252	12	”	"	''
10_1101-2021_02_13_429885	252	13	​Nature	​nature	JJ
10_1101-2021_02_13_429885	252	14	Methods​	Methods​	NNP
10_1101-2021_02_13_429885	252	15	10	10	CD
10_1101-2021_02_13_429885	252	16	(	(	-LRB-
10_1101-2021_02_13_429885	252	17	11	11	CD
10_1101-2021_02_13_429885	252	18	)	)	-RRB-
10_1101-2021_02_13_429885	252	19	:	:	:
10_1101-2021_02_13_429885	252	20	1081–82	1081–82	LS
10_1101-2021_02_13_429885	252	21	.	.	.
10_1101-2021_02_13_429885	253	1	https://doi.org/​10.1038/nmeth.2642	https://doi.org/​10.1038/nmeth.2642	RB
10_1101-2021_02_13_429885	253	2	​.	​.	JJ
10_1101-2021_02_13_429885	254	1	Greaves	Greaves	NNP
10_1101-2021_02_13_429885	254	2	,	,	,
10_1101-2021_02_13_429885	254	3	Mel	Mel	NNP
10_1101-2021_02_13_429885	254	4	,	,	,
10_1101-2021_02_13_429885	254	5	and	and	CC
10_1101-2021_02_13_429885	254	6	Carlo	Carlo	NNP
10_1101-2021_02_13_429885	254	7	C.	C.	NNP
10_1101-2021_02_13_429885	254	8	Maley	Maley	NNP
10_1101-2021_02_13_429885	254	9	.	.	.
10_1101-2021_02_13_429885	255	1	2012	2012	CD
10_1101-2021_02_13_429885	255	2	.	.	.
10_1101-2021_02_13_429885	256	1	“	"	``
10_1101-2021_02_13_429885	256	2	Clonal	Clonal	NNP
10_1101-2021_02_13_429885	256	3	Evolution	Evolution	NNP
10_1101-2021_02_13_429885	256	4	in	in	IN
10_1101-2021_02_13_429885	256	5	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	256	6	.	.	.
10_1101-2021_02_13_429885	256	7	”	"	''
10_1101-2021_02_13_429885	256	8	​Nature​	​nature​	CD
10_1101-2021_02_13_429885	256	9	481	481	CD
10_1101-2021_02_13_429885	256	10	(	(	-LRB-
10_1101-2021_02_13_429885	256	11	7381	7381	CD
10_1101-2021_02_13_429885	256	12	)	)	-RRB-
10_1101-2021_02_13_429885	256	13	:	:	:
10_1101-2021_02_13_429885	256	14	306–13	306–13	CD
10_1101-2021_02_13_429885	256	15	.	.	.
10_1101-2021_02_13_429885	257	1	https://doi.org/​10.1038/nature10762	https://doi.org/​10.1038/nature10762	NNS
10_1101-2021_02_13_429885	257	2	​.	​.	JJ
10_1101-2021_02_13_429885	258	1	Jamal	Jamal	NNP
10_1101-2021_02_13_429885	258	2	-	-	HYPH
10_1101-2021_02_13_429885	258	3	Hanjani	Hanjani	NNP
10_1101-2021_02_13_429885	258	4	,	,	,
10_1101-2021_02_13_429885	258	5	Mariam	Mariam	NNP
10_1101-2021_02_13_429885	258	6	,	,	,
10_1101-2021_02_13_429885	258	7	Gareth	Gareth	NNP
10_1101-2021_02_13_429885	258	8	A.	A.	NNP
10_1101-2021_02_13_429885	258	9	Wilson	Wilson	NNP
10_1101-2021_02_13_429885	258	10	,	,	,
10_1101-2021_02_13_429885	258	11	Nicholas	Nicholas	NNP
10_1101-2021_02_13_429885	258	12	McGranahan	McGranahan	NNP
10_1101-2021_02_13_429885	258	13	,	,	,
10_1101-2021_02_13_429885	258	14	Nicolai	Nicolai	NNP
10_1101-2021_02_13_429885	258	15	J.	J.	NNP
10_1101-2021_02_13_429885	258	16	Birkbak	Birkbak	NNP
10_1101-2021_02_13_429885	258	17	,	,	,
10_1101-2021_02_13_429885	258	18	Thomas	Thomas	NNP
10_1101-2021_02_13_429885	258	19	B.	B.	NNP
10_1101-2021_02_13_429885	258	20	K.	K.	NNP
10_1101-2021_02_13_429885	258	21	Watkins	Watkins	NNP
10_1101-2021_02_13_429885	258	22	,	,	,
10_1101-2021_02_13_429885	258	23	Selvaraju	Selvaraju	NNP
10_1101-2021_02_13_429885	258	24	Veeriah	Veeriah	NNP
10_1101-2021_02_13_429885	258	25	,	,	,
10_1101-2021_02_13_429885	258	26	Seema	Seema	NNP
10_1101-2021_02_13_429885	258	27	Shafi	Shafi	NNP
10_1101-2021_02_13_429885	258	28	,	,	,
10_1101-2021_02_13_429885	258	29	et	et	NNP
10_1101-2021_02_13_429885	258	30	al	al	NNP
10_1101-2021_02_13_429885	258	31	.	.	.
10_1101-2021_02_13_429885	259	1	2017	2017	CD
10_1101-2021_02_13_429885	259	2	.	.	.
10_1101-2021_02_13_429885	260	1	“	"	``
10_1101-2021_02_13_429885	260	2	Tracking	track	VBG
10_1101-2021_02_13_429885	260	3	the	the	DT
10_1101-2021_02_13_429885	260	4	Evolution	Evolution	NNP
10_1101-2021_02_13_429885	260	5	of	of	IN
10_1101-2021_02_13_429885	260	6	Non	non	JJ
10_1101-2021_02_13_429885	260	7	-	-	JJ
10_1101-2021_02_13_429885	260	8	Small	small	JJ
10_1101-2021_02_13_429885	260	9	-	-	HYPH
10_1101-2021_02_13_429885	260	10	Cell	Cell	NNP
10_1101-2021_02_13_429885	260	11	Lung	Lung	NNP
10_1101-2021_02_13_429885	260	12	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	260	13	.	.	.
10_1101-2021_02_13_429885	260	14	”	"	''
10_1101-2021_02_13_429885	260	15	​The	​The	NNP
10_1101-2021_02_13_429885	260	16	New	New	NNP
10_1101-2021_02_13_429885	260	17	England	England	NNP
10_1101-2021_02_13_429885	260	18	Journal	Journal	NNP
10_1101-2021_02_13_429885	260	19	of	of	IN
10_1101-2021_02_13_429885	260	20	Medicine​	Medicine​	NNP
10_1101-2021_02_13_429885	260	21	376	376	CD
10_1101-2021_02_13_429885	260	22	(	(	-LRB-
10_1101-2021_02_13_429885	260	23	22	22	CD
10_1101-2021_02_13_429885	260	24	)	)	-RRB-
10_1101-2021_02_13_429885	260	25	:	:	:
10_1101-2021_02_13_429885	260	26	2109–21	2109–21	LS
10_1101-2021_02_13_429885	260	27	.	.	.
10_1101-2021_02_13_429885	261	1	https://doi.org/​10.1056/NEJMoa1616288	https://doi.org/​10.1056/nejmoa1616288	CD
10_1101-2021_02_13_429885	261	2	​.	​.	CD
10_1101-2021_02_13_429885	262	1	Kent	Kent	NNP
10_1101-2021_02_13_429885	262	2	,	,	,
10_1101-2021_02_13_429885	262	3	David	David	NNP
10_1101-2021_02_13_429885	262	4	G.	G.	NNP
10_1101-2021_02_13_429885	262	5	,	,	,
10_1101-2021_02_13_429885	262	6	and	and	CC
10_1101-2021_02_13_429885	262	7	Anthony	Anthony	NNP
10_1101-2021_02_13_429885	262	8	R.	R.	NNP
10_1101-2021_02_13_429885	262	9	Green	Green	NNP
10_1101-2021_02_13_429885	262	10	.	.	.
10_1101-2021_02_13_429885	263	1	2017	2017	CD
10_1101-2021_02_13_429885	263	2	-	-	SYM
10_1101-2021_02_13_429885	263	3	4	4	CD
10_1101-2021_02_13_429885	263	4	.	.	.
10_1101-2021_02_13_429885	264	1	“	"	``
10_1101-2021_02_13_429885	264	2	Order	order	NN
10_1101-2021_02_13_429885	264	3	Matters	matter	NNS
10_1101-2021_02_13_429885	264	4	:	:	:
10_1101-2021_02_13_429885	264	5	The	the	DT
10_1101-2021_02_13_429885	264	6	Order	order	NN
10_1101-2021_02_13_429885	264	7	of	of	IN
10_1101-2021_02_13_429885	264	8	Somatic	somatic	JJ
10_1101-2021_02_13_429885	264	9	Mutations	Mutations	NNPS
10_1101-2021_02_13_429885	264	10	Influences	Influences	NNPS
10_1101-2021_02_13_429885	264	11	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	264	12	Evolution	Evolution	NNP
10_1101-2021_02_13_429885	264	13	.	.	.
10_1101-2021_02_13_429885	264	14	”	"	''
10_1101-2021_02_13_429885	264	15	​Cold	​Cold	``
10_1101-2021_02_13_429885	264	16	Spring	Spring	NNP
10_1101-2021_02_13_429885	264	17	Harbor	Harbor	NNP
10_1101-2021_02_13_429885	264	18	Perspectives	Perspectives	NNPS
10_1101-2021_02_13_429885	264	19	in	in	IN
10_1101-2021_02_13_429885	264	20	Medicine​	Medicine​	NNP
10_1101-2021_02_13_429885	264	21	7	7	CD
10_1101-2021_02_13_429885	264	22	(	(	-LRB-
10_1101-2021_02_13_429885	264	23	4	4	CD
10_1101-2021_02_13_429885	264	24	)	)	-RRB-
10_1101-2021_02_13_429885	264	25	.	.	.
10_1101-2021_02_13_429885	265	1	https://doi.org/​10.1101/cshperspect.a027060	https://doi.org/​10.1101/cshperspect.a027060	NNP
10_1101-2021_02_13_429885	265	2	​.	​.	CD
10_1101-2021_02_13_429885	266	1	Landau	Landau	NNS
10_1101-2021_02_13_429885	266	2	,	,	,
10_1101-2021_02_13_429885	266	3	Dan	Dan	NNP
10_1101-2021_02_13_429885	266	4	A.	A.	NNP
10_1101-2021_02_13_429885	266	5	,	,	,
10_1101-2021_02_13_429885	266	6	Scott	Scott	NNP
10_1101-2021_02_13_429885	266	7	L.	L.	NNP
10_1101-2021_02_13_429885	266	8	Carter	Carter	NNP
10_1101-2021_02_13_429885	266	9	,	,	,
10_1101-2021_02_13_429885	266	10	Petar	Petar	NNP
10_1101-2021_02_13_429885	266	11	Stojanov	Stojanov	NNP
10_1101-2021_02_13_429885	266	12	,	,	,
10_1101-2021_02_13_429885	266	13	Aaron	Aaron	NNP
10_1101-2021_02_13_429885	266	14	McKenna	McKenna	NNP
10_1101-2021_02_13_429885	266	15	,	,	,
10_1101-2021_02_13_429885	266	16	Kristen	Kristen	NNP
10_1101-2021_02_13_429885	266	17	Stevenson	Stevenson	NNP
10_1101-2021_02_13_429885	266	18	,	,	,
10_1101-2021_02_13_429885	266	19	Michael	Michael	NNP
10_1101-2021_02_13_429885	266	20	S.	S.	NNP
10_1101-2021_02_13_429885	266	21	Lawrence	Lawrence	NNP
10_1101-2021_02_13_429885	266	22	,	,	,
10_1101-2021_02_13_429885	266	23	Carrie	Carrie	NNP
10_1101-2021_02_13_429885	266	24	Sougnez	Sougnez	NNP
10_1101-2021_02_13_429885	266	25	,	,	,
10_1101-2021_02_13_429885	266	26	et	et	NNP
10_1101-2021_02_13_429885	266	27	al	al	NNP
10_1101-2021_02_13_429885	266	28	.	.	.
10_1101-2021_02_13_429885	267	1	2013	2013	CD
10_1101-2021_02_13_429885	267	2	.	.	.
10_1101-2021_02_13_429885	268	1	“	"	``
10_1101-2021_02_13_429885	268	2	Evolution	Evolution	NNP
10_1101-2021_02_13_429885	268	3	and	and	CC
10_1101-2021_02_13_429885	268	4	Impact	Impact	NNP
10_1101-2021_02_13_429885	268	5	of	of	IN
10_1101-2021_02_13_429885	268	6	Subclonal	Subclonal	NNP
10_1101-2021_02_13_429885	268	7	Mutations	Mutations	NNPS
10_1101-2021_02_13_429885	268	8	in	in	IN
10_1101-2021_02_13_429885	268	9	Chronic	Chronic	NNP
10_1101-2021_02_13_429885	268	10	Lymphocytic	Lymphocytic	NNP
10_1101-2021_02_13_429885	268	11	Leukemia	Leukemia	NNP
10_1101-2021_02_13_429885	268	12	.	.	.
10_1101-2021_02_13_429885	268	13	”	"	''
10_1101-2021_02_13_429885	268	14	​Cell​	​Cell​	NNP
10_1101-2021_02_13_429885	268	15	152	152	CD
10_1101-2021_02_13_429885	268	16	(	(	-LRB-
10_1101-2021_02_13_429885	268	17	4	4	CD
10_1101-2021_02_13_429885	268	18	)	)	-RRB-
10_1101-2021_02_13_429885	268	19	:	:	:
10_1101-2021_02_13_429885	268	20	714–26	714–26	CD
10_1101-2021_02_13_429885	268	21	.	.	.
10_1101-2021_02_13_429885	269	1	https://doi.org/​10.1016/j.cell.2013.01.019	https://doi.org/​10.1016/j.cell.2013.01.019	NNP
10_1101-2021_02_13_429885	269	2	​.	​.	CD
10_1101-2021_02_13_429885	270	1	Levine	Levine	NNP
10_1101-2021_02_13_429885	270	2	,	,	,
10_1101-2021_02_13_429885	270	3	Arnold	Arnold	NNP
10_1101-2021_02_13_429885	270	4	J.	J.	NNP
10_1101-2021_02_13_429885	270	5	,	,	,
10_1101-2021_02_13_429885	270	6	Nancy	Nancy	NNP
10_1101-2021_02_13_429885	270	7	A.	A.	NNP
10_1101-2021_02_13_429885	270	8	Jenkins	Jenkins	NNP
10_1101-2021_02_13_429885	270	9	,	,	,
10_1101-2021_02_13_429885	270	10	and	and	CC
10_1101-2021_02_13_429885	270	11	Neal	Neal	NNP
10_1101-2021_02_13_429885	270	12	G.	G.	NNP
10_1101-2021_02_13_429885	270	13	Copeland	Copeland	NNP
10_1101-2021_02_13_429885	270	14	.	.	.
10_1101-2021_02_13_429885	271	1	2019	2019	CD
10_1101-2021_02_13_429885	271	2	.	.	.
10_1101-2021_02_13_429885	272	1	“	"	``
10_1101-2021_02_13_429885	272	2	The	the	DT
10_1101-2021_02_13_429885	272	3	Roles	Roles	NNPS
10_1101-2021_02_13_429885	272	4	of	of	IN
10_1101-2021_02_13_429885	272	5	Initiating	Initiating	NNP
10_1101-2021_02_13_429885	272	6	Truncal	Truncal	NNP
10_1101-2021_02_13_429885	272	7	Mutations	Mutations	NNPS
10_1101-2021_02_13_429885	272	8	in	in	IN
10_1101-2021_02_13_429885	272	9	Human	Human	NNP
10_1101-2021_02_13_429885	272	10	Cancers	Cancers	NNPS
10_1101-2021_02_13_429885	272	11	:	:	:
10_1101-2021_02_13_429885	272	12	The	the	DT
10_1101-2021_02_13_429885	272	13	Order	order	NN
10_1101-2021_02_13_429885	272	14	of	of	IN
10_1101-2021_02_13_429885	272	15	Mutations	Mutations	NNPS
10_1101-2021_02_13_429885	272	16	and	and	CC
10_1101-2021_02_13_429885	272	17	Tumor	Tumor	NNP
10_1101-2021_02_13_429885	272	18	Cell	Cell	NNP
10_1101-2021_02_13_429885	272	19	Type	Type	NNP
10_1101-2021_02_13_429885	272	20	Matters	Matters	NNPS
10_1101-2021_02_13_429885	272	21	.	.	.
10_1101-2021_02_13_429885	272	22	”	"	''
10_1101-2021_02_13_429885	272	23	​Cancer	​cancer	NN
10_1101-2021_02_13_429885	272	24	Cell​	cell​	CD
10_1101-2021_02_13_429885	272	25	35	35	CD
10_1101-2021_02_13_429885	272	26	(	(	-LRB-
10_1101-2021_02_13_429885	272	27	1	1	CD
10_1101-2021_02_13_429885	272	28	)	)	-RRB-
10_1101-2021_02_13_429885	272	29	:	:	:
10_1101-2021_02_13_429885	272	30	10–15	10–15	LS
10_1101-2021_02_13_429885	272	31	.	.	.
10_1101-2021_02_13_429885	273	1	https://doi.org/​10.1016/j.ccell.2018.11.009	https://doi.org/​10.1016/j.ccell.2018.11.009	NNP
10_1101-2021_02_13_429885	273	2	​.	​.	NNP
10_1101-2021_02_13_429885	274	1	Li	Li	NNP
10_1101-2021_02_13_429885	274	2	,	,	,
10_1101-2021_02_13_429885	274	3	Yilong	Yilong	NNP
10_1101-2021_02_13_429885	274	4	,	,	,
10_1101-2021_02_13_429885	274	5	Nicola	Nicola	NNP
10_1101-2021_02_13_429885	274	6	D.	D.	NNP
10_1101-2021_02_13_429885	274	7	Roberts	Roberts	NNP
10_1101-2021_02_13_429885	274	8	,	,	,
10_1101-2021_02_13_429885	274	9	Jeremiah	Jeremiah	NNP
10_1101-2021_02_13_429885	274	10	A.	a.	NN
10_1101-2021_02_13_429885	274	11	Wala	Wala	NNP
10_1101-2021_02_13_429885	274	12	,	,	,
10_1101-2021_02_13_429885	274	13	Ofer	Ofer	NNP
10_1101-2021_02_13_429885	274	14	Shapira	Shapira	NNP
10_1101-2021_02_13_429885	274	15	,	,	,
10_1101-2021_02_13_429885	274	16	Steven	Steven	NNP
10_1101-2021_02_13_429885	274	17	E.	E.	NNP
10_1101-2021_02_13_429885	274	18	Schumacher	Schumacher	NNP
10_1101-2021_02_13_429885	274	19	,	,	,
10_1101-2021_02_13_429885	274	20	Kiran	Kiran	NNP
10_1101-2021_02_13_429885	274	21	Kumar	Kumar	NNP
10_1101-2021_02_13_429885	274	22	,	,	,
10_1101-2021_02_13_429885	274	23	Ekta	Ekta	NNP
10_1101-2021_02_13_429885	274	24	Khurana	Khurana	NNP
10_1101-2021_02_13_429885	274	25	,	,	,
10_1101-2021_02_13_429885	274	26	et	et	NNP
10_1101-2021_02_13_429885	274	27	al	al	NNP
10_1101-2021_02_13_429885	274	28	.	.	.
10_1101-2021_02_13_429885	275	1	2020	2020	CD
10_1101-2021_02_13_429885	275	2	.	.	.
10_1101-2021_02_13_429885	276	1	“	"	``
10_1101-2021_02_13_429885	276	2	Patterns	Patterns	NNPS
10_1101-2021_02_13_429885	276	3	of	of	IN
10_1101-2021_02_13_429885	276	4	Somatic	Somatic	NNP
10_1101-2021_02_13_429885	276	5	Structural	Structural	NNP
10_1101-2021_02_13_429885	276	6	Variation	Variation	NNP
10_1101-2021_02_13_429885	276	7	in	in	IN
10_1101-2021_02_13_429885	276	8	Human	Human	NNP
10_1101-2021_02_13_429885	276	9	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	276	10	Genomes	Genomes	NNPS
10_1101-2021_02_13_429885	276	11	.	.	.
10_1101-2021_02_13_429885	276	12	”	"	''
10_1101-2021_02_13_429885	276	13	​Nature​	​Nature​	NNP
10_1101-2021_02_13_429885	276	14	578	578	CD
10_1101-2021_02_13_429885	276	15	(	(	-LRB-
10_1101-2021_02_13_429885	276	16	7793	7793	CD
10_1101-2021_02_13_429885	276	17	)	)	-RRB-
10_1101-2021_02_13_429885	276	18	:	:	:
10_1101-2021_02_13_429885	276	19	112–21	112–21	CD
10_1101-2021_02_13_429885	276	20	.	.	.
10_1101-2021_02_13_429885	277	1	https://doi.org/​10.1038/s41586-019-1913-9	https://doi.org/​10.1038/s41586-019-1913-9	NNP
10_1101-2021_02_13_429885	277	2	​.	​.	NNP
10_1101-2021_02_13_429885	278	1	Macintyre	Macintyre	NNP
10_1101-2021_02_13_429885	278	2	,	,	,
10_1101-2021_02_13_429885	278	3	Geoff	Geoff	NNP
10_1101-2021_02_13_429885	278	4	,	,	,
10_1101-2021_02_13_429885	278	5	Teodora	Teodora	NNP
10_1101-2021_02_13_429885	278	6	E.	E.	NNP
10_1101-2021_02_13_429885	278	7	Goranova	Goranova	NNP
10_1101-2021_02_13_429885	278	8	,	,	,
10_1101-2021_02_13_429885	278	9	Dilrini	Dilrini	NNP
10_1101-2021_02_13_429885	278	10	De	De	NNP
10_1101-2021_02_13_429885	278	11	Silva	Silva	NNP
10_1101-2021_02_13_429885	278	12	,	,	,
10_1101-2021_02_13_429885	278	13	Darren	Darren	NNP
10_1101-2021_02_13_429885	278	14	Ennis	Ennis	NNP
10_1101-2021_02_13_429885	278	15	,	,	,
10_1101-2021_02_13_429885	278	16	Anna	Anna	NNP
10_1101-2021_02_13_429885	278	17	M.	M.	NNP
10_1101-2021_02_13_429885	278	18	Piskorz	Piskorz	NNP
10_1101-2021_02_13_429885	278	19	,	,	,
10_1101-2021_02_13_429885	278	20	Matthew	Matthew	NNP
10_1101-2021_02_13_429885	278	21	Eldridge	Eldridge	NNP
10_1101-2021_02_13_429885	278	22	,	,	,
10_1101-2021_02_13_429885	278	23	Daoud	Daoud	NNP
10_1101-2021_02_13_429885	278	24	Sie	Sie	NNP
10_1101-2021_02_13_429885	278	25	,	,	,
10_1101-2021_02_13_429885	278	26	et	et	NNP
10_1101-2021_02_13_429885	278	27	al	al	NNP
10_1101-2021_02_13_429885	278	28	.	.	.
10_1101-2021_02_13_429885	279	1	2018	2018	CD
10_1101-2021_02_13_429885	279	2	.	.	.
10_1101-2021_02_13_429885	280	1	“	"	``
10_1101-2021_02_13_429885	280	2	Copy	copy	VB
10_1101-2021_02_13_429885	280	3	Number	number	NN
10_1101-2021_02_13_429885	280	4	Signatures	signature	NNS
10_1101-2021_02_13_429885	280	5	and	and	CC
10_1101-2021_02_13_429885	280	6	Mutational	mutational	JJ
10_1101-2021_02_13_429885	280	7	Processes	Processes	NNPS
10_1101-2021_02_13_429885	280	8	in	in	IN
10_1101-2021_02_13_429885	280	9	Ovarian	Ovarian	NNP
10_1101-2021_02_13_429885	280	10	Carcinoma	Carcinoma	NNP
10_1101-2021_02_13_429885	280	11	.	.	.
10_1101-2021_02_13_429885	280	12	”	"	''
10_1101-2021_02_13_429885	280	13	​Nature	​nature	JJ
10_1101-2021_02_13_429885	280	14	Genetics​	genetics​	NN
10_1101-2021_02_13_429885	280	15	50	50	CD
10_1101-2021_02_13_429885	280	16	(	(	-LRB-
10_1101-2021_02_13_429885	280	17	9	9	CD
10_1101-2021_02_13_429885	280	18	)	)	-RRB-
10_1101-2021_02_13_429885	280	19	:	:	:
10_1101-2021_02_13_429885	280	20	1262–70	1262–70	CD
10_1101-2021_02_13_429885	280	21	.	.	.
10_1101-2021_02_13_429885	281	1	https://doi.org/​10.1038/s41588-018-0179-8	https://doi.org/​10.1038/s41588-018-0179-8	NNS
10_1101-2021_02_13_429885	281	2	​.	​.	CD
10_1101-2021_02_13_429885	282	1	Martincorena	Martincorena	NNP
10_1101-2021_02_13_429885	282	2	,	,	,
10_1101-2021_02_13_429885	282	3	Iñigo	Iñigo	NNP
10_1101-2021_02_13_429885	282	4	,	,	,
10_1101-2021_02_13_429885	282	5	Joanna	Joanna	NNP
10_1101-2021_02_13_429885	282	6	C.	C.	NNP
10_1101-2021_02_13_429885	282	7	Fowler	Fowler	NNP
10_1101-2021_02_13_429885	282	8	,	,	,
10_1101-2021_02_13_429885	282	9	Agnieszka	Agnieszka	NNP
10_1101-2021_02_13_429885	282	10	Wabik	Wabik	NNP
10_1101-2021_02_13_429885	282	11	,	,	,
10_1101-2021_02_13_429885	282	12	Andrew	Andrew	NNP
10_1101-2021_02_13_429885	282	13	R.	R.	NNP
10_1101-2021_02_13_429885	282	14	J.	J.	NNP
10_1101-2021_02_13_429885	282	15	Lawson	Lawson	NNP
10_1101-2021_02_13_429885	282	16	,	,	,
10_1101-2021_02_13_429885	282	17	Federico	Federico	NNP
10_1101-2021_02_13_429885	282	18	Abascal	Abascal	NNP
10_1101-2021_02_13_429885	282	19	,	,	,
10_1101-2021_02_13_429885	282	20	Michael	Michael	NNP
10_1101-2021_02_13_429885	282	21	W.	W.	NNP
10_1101-2021_02_13_429885	282	22	J.	J.	NNP
10_1101-2021_02_13_429885	283	1	Hall	Hall	NNP
10_1101-2021_02_13_429885	283	2	,	,	,
10_1101-2021_02_13_429885	283	3	Alex	Alex	NNP
10_1101-2021_02_13_429885	283	4	Cagan	Cagan	NNP
10_1101-2021_02_13_429885	283	5	,	,	,
10_1101-2021_02_13_429885	283	6	et	et	NNP
10_1101-2021_02_13_429885	283	7	al	al	NNP
10_1101-2021_02_13_429885	283	8	.	.	.
10_1101-2021_02_13_429885	284	1	2018	2018	CD
10_1101-2021_02_13_429885	284	2	.	.	.
10_1101-2021_02_13_429885	285	1	“	"	``
10_1101-2021_02_13_429885	285	2	Somatic	Somatic	NNP
10_1101-2021_02_13_429885	285	3	Mutant	Mutant	NNP
10_1101-2021_02_13_429885	285	4	Clones	Clones	NNPS
10_1101-2021_02_13_429885	285	5	Colonize	colonize	VBP
10_1101-2021_02_13_429885	285	6	the	the	DT
10_1101-2021_02_13_429885	285	7	Human	Human	NNP
10_1101-2021_02_13_429885	285	8	Esophagus	Esophagus	NNP
10_1101-2021_02_13_429885	285	9	with	with	IN
10_1101-2021_02_13_429885	285	10	Age	Age	NNP
10_1101-2021_02_13_429885	285	11	.	.	.
10_1101-2021_02_13_429885	285	12	”	"	''
10_1101-2021_02_13_429885	285	13	​Science​	​science​	CD
10_1101-2021_02_13_429885	285	14	362	362	CD
10_1101-2021_02_13_429885	285	15	(	(	-LRB-
10_1101-2021_02_13_429885	285	16	6417	6417	CD
10_1101-2021_02_13_429885	285	17	)	)	-RRB-
10_1101-2021_02_13_429885	285	18	:	:	:
10_1101-2021_02_13_429885	285	19	911–17	911–17	CD
10_1101-2021_02_13_429885	285	20	.	.	.
10_1101-2021_02_13_429885	286	1	https://doi.org/​10.1126/science.aau3879	https://doi.org/​10.1126/science.aau3879	NNP
10_1101-2021_02_13_429885	286	2	​.	​.	NNP
10_1101-2021_02_13_429885	287	1	Martincorena	Martincorena	NNP
10_1101-2021_02_13_429885	287	2	,	,	,
10_1101-2021_02_13_429885	287	3	Iñigo	Iñigo	NNP
10_1101-2021_02_13_429885	287	4	,	,	,
10_1101-2021_02_13_429885	287	5	Amit	Amit	NNP
10_1101-2021_02_13_429885	287	6	Roshan	Roshan	NNP
10_1101-2021_02_13_429885	287	7	,	,	,
10_1101-2021_02_13_429885	287	8	Moritz	Moritz	NNP
10_1101-2021_02_13_429885	287	9	Gerstung	Gerstung	NNP
10_1101-2021_02_13_429885	287	10	,	,	,
10_1101-2021_02_13_429885	287	11	Peter	Peter	NNP
10_1101-2021_02_13_429885	287	12	Ellis	Ellis	NNP
10_1101-2021_02_13_429885	287	13	,	,	,
10_1101-2021_02_13_429885	287	14	Peter	Peter	NNP
10_1101-2021_02_13_429885	287	15	Van	Van	NNP
10_1101-2021_02_13_429885	287	16	Loo	Loo	NNP
10_1101-2021_02_13_429885	287	17	,	,	,
10_1101-2021_02_13_429885	287	18	Stuart	Stuart	NNP
10_1101-2021_02_13_429885	287	19	McLaren	McLaren	NNP
10_1101-2021_02_13_429885	287	20	,	,	,
10_1101-2021_02_13_429885	287	21	David	David	NNP
10_1101-2021_02_13_429885	287	22	C.	C.	NNP
10_1101-2021_02_13_429885	287	23	Wedge	Wedge	NNP
10_1101-2021_02_13_429885	287	24	,	,	,
10_1101-2021_02_13_429885	287	25	et	et	NNP
10_1101-2021_02_13_429885	287	26	al	al	NNP
10_1101-2021_02_13_429885	287	27	.	.	.
10_1101-2021_02_13_429885	288	1	2015	2015	CD
10_1101-2021_02_13_429885	288	2	.	.	.
10_1101-2021_02_13_429885	289	1	“	"	``
10_1101-2021_02_13_429885	289	2	High	High	NNP
10_1101-2021_02_13_429885	289	3	Burden	Burden	NNP
10_1101-2021_02_13_429885	289	4	and	and	CC
10_1101-2021_02_13_429885	289	5	Pervasive	Pervasive	NNP
10_1101-2021_02_13_429885	289	6	Positive	Positive	NNP
10_1101-2021_02_13_429885	289	7	Selection	Selection	NNP
10_1101-2021_02_13_429885	289	8	of	of	IN
10_1101-2021_02_13_429885	289	9	Somatic	Somatic	NNP
10_1101-2021_02_13_429885	289	10	Mutations	Mutations	NNPS
10_1101-2021_02_13_429885	289	11	in	in	IN
10_1101-2021_02_13_429885	289	12	Normal	Normal	NNP
10_1101-2021_02_13_429885	289	13	Human	Human	NNP
10_1101-2021_02_13_429885	289	14	Skin	Skin	NNP
10_1101-2021_02_13_429885	289	15	.	.	.
10_1101-2021_02_13_429885	289	16	”	"	''
10_1101-2021_02_13_429885	289	17	​Science​	​science​	CD
10_1101-2021_02_13_429885	289	18	348	348	CD
10_1101-2021_02_13_429885	289	19	(	(	-LRB-
10_1101-2021_02_13_429885	289	20	6237	6237	CD
10_1101-2021_02_13_429885	289	21	)	)	-RRB-
10_1101-2021_02_13_429885	289	22	:	:	:
10_1101-2021_02_13_429885	289	23	880–86	880–86	CD
10_1101-2021_02_13_429885	289	24	.	.	.
10_1101-2021_02_13_429885	290	1	https://doi.org/​10.1126/science.aaa6806	https://doi.org/​10.1126/science.aaa6806	VBD
10_1101-2021_02_13_429885	290	2	​.	​.	NNP
10_1101-2021_02_13_429885	291	1	McGranahan	McGranahan	NNP
10_1101-2021_02_13_429885	291	2	,	,	,
10_1101-2021_02_13_429885	291	3	Nicholas	Nicholas	NNP
10_1101-2021_02_13_429885	291	4	,	,	,
10_1101-2021_02_13_429885	291	5	and	and	CC
10_1101-2021_02_13_429885	291	6	Charles	Charles	NNP
10_1101-2021_02_13_429885	291	7	Swanton	Swanton	NNP
10_1101-2021_02_13_429885	291	8	.	.	.
10_1101-2021_02_13_429885	292	1	2015	2015	CD
10_1101-2021_02_13_429885	292	2	.	.	.
10_1101-2021_02_13_429885	293	1	“	"	``
10_1101-2021_02_13_429885	293	2	Biological	biological	JJ
10_1101-2021_02_13_429885	293	3	and	and	CC
10_1101-2021_02_13_429885	293	4	Therapeutic	therapeutic	JJ
10_1101-2021_02_13_429885	293	5	Impact	impact	NN
10_1101-2021_02_13_429885	293	6	of	of	IN
10_1101-2021_02_13_429885	293	7	Intratumor	intratumor	JJ
10_1101-2021_02_13_429885	293	8	Heterogeneity	Heterogeneity	NNP
10_1101-2021_02_13_429885	293	9	in	in	IN
10_1101-2021_02_13_429885	293	10	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	293	11	Evolution	Evolution	NNP
10_1101-2021_02_13_429885	293	12	.	.	.
10_1101-2021_02_13_429885	293	13	”	"	''
10_1101-2021_02_13_429885	293	14	​Cancer	​cancer	NN
10_1101-2021_02_13_429885	293	15	Cell​	cell​	CD
10_1101-2021_02_13_429885	293	16	27	27	CD
10_1101-2021_02_13_429885	293	17	(	(	-LRB-
10_1101-2021_02_13_429885	293	18	1	1	CD
10_1101-2021_02_13_429885	293	19	)	)	-RRB-
10_1101-2021_02_13_429885	293	20	:	:	:
10_1101-2021_02_13_429885	293	21	15–26	15–26	CD
10_1101-2021_02_13_429885	293	22	.	.	.
10_1101-2021_02_13_429885	294	1	https://doi.org/​10.1016/j.ccell.2014.12.001	https://doi.org/​10.1016/j.ccell.2014.12.001	NNP
10_1101-2021_02_13_429885	294	2	​.	​.	NNP
10_1101-2021_02_13_429885	295	1	—	—	:
10_1101-2021_02_13_429885	295	2	—	—	:
10_1101-2021_02_13_429885	295	3	—	—	:
10_1101-2021_02_13_429885	295	4	.	.	.
10_1101-2021_02_13_429885	296	1	2017	2017	CD
10_1101-2021_02_13_429885	296	2	.	.	.
10_1101-2021_02_13_429885	297	1	“	"	``
10_1101-2021_02_13_429885	297	2	Clonal	clonal	JJ
10_1101-2021_02_13_429885	297	3	Heterogeneity	Heterogeneity	NNP
10_1101-2021_02_13_429885	297	4	and	and	CC
10_1101-2021_02_13_429885	297	5	Tumor	Tumor	NNP
10_1101-2021_02_13_429885	297	6	Evolution	Evolution	NNP
10_1101-2021_02_13_429885	297	7	:	:	:
10_1101-2021_02_13_429885	297	8	Past	past	JJ
10_1101-2021_02_13_429885	297	9	,	,	,
10_1101-2021_02_13_429885	297	10	Present	present	NN
10_1101-2021_02_13_429885	297	11	,	,	,
10_1101-2021_02_13_429885	297	12	and	and	CC
10_1101-2021_02_13_429885	297	13	the	the	DT
10_1101-2021_02_13_429885	297	14	Future	Future	NNP
10_1101-2021_02_13_429885	297	15	.	.	.
10_1101-2021_02_13_429885	297	16	”	"	''
10_1101-2021_02_13_429885	297	17	​Cell	​Cell	VBG
10_1101-2021_02_13_429885	297	18	168	168	CD
10_1101-2021_02_13_429885	297	19	(	(	-LRB-
10_1101-2021_02_13_429885	297	20	4	4	CD
10_1101-2021_02_13_429885	297	21	)	)	-RRB-
10_1101-2021_02_13_429885	297	22	:	:	:
10_1101-2021_02_13_429885	297	23	613–28	613–28	CD
10_1101-2021_02_13_429885	297	24	.	.	.
10_1101-2021_02_13_429885	298	1	https://doi.org/​10.1016/j.cell.2017.01.018	https://doi.org/​10.1016/j.cell.2017.01.018	NNP
10_1101-2021_02_13_429885	298	2	​.	​.	CD
10_1101-2021_02_13_429885	299	1	Nik	Nik	NNP
10_1101-2021_02_13_429885	299	2	-	-	HYPH
10_1101-2021_02_13_429885	299	3	Zainal	Zainal	NNP
10_1101-2021_02_13_429885	299	4	,	,	,
10_1101-2021_02_13_429885	299	5	Serena	Serena	NNP
10_1101-2021_02_13_429885	299	6	,	,	,
10_1101-2021_02_13_429885	299	7	Peter	Peter	NNP
10_1101-2021_02_13_429885	299	8	Van	Van	NNP
10_1101-2021_02_13_429885	299	9	Loo	Loo	NNP
10_1101-2021_02_13_429885	299	10	,	,	,
10_1101-2021_02_13_429885	299	11	David	David	NNP
10_1101-2021_02_13_429885	299	12	C.	C.	NNP
10_1101-2021_02_13_429885	299	13	Wedge	Wedge	NNP
10_1101-2021_02_13_429885	299	14	,	,	,
10_1101-2021_02_13_429885	299	15	Ludmil	Ludmil	NNP
10_1101-2021_02_13_429885	299	16	B.	B.	NNP
10_1101-2021_02_13_429885	299	17	Alexandrov	Alexandrov	NNP
10_1101-2021_02_13_429885	299	18	,	,	,
10_1101-2021_02_13_429885	299	19	Christopher	Christopher	NNP
10_1101-2021_02_13_429885	299	20	D.	D.	NNP
10_1101-2021_02_13_429885	299	21	Greenman	Greenman	NNP
10_1101-2021_02_13_429885	299	22	,	,	,
10_1101-2021_02_13_429885	299	23	King	King	NNP
10_1101-2021_02_13_429885	299	24	Wai	Wai	NNP
10_1101-2021_02_13_429885	299	25	Lau	Lau	NNP
10_1101-2021_02_13_429885	299	26	,	,	,
10_1101-2021_02_13_429885	299	27	Keiran	Keiran	NNP
10_1101-2021_02_13_429885	299	28	Raine	Raine	NNP
10_1101-2021_02_13_429885	299	29	,	,	,
10_1101-2021_02_13_429885	299	30	et	et	NNP
10_1101-2021_02_13_429885	299	31	al	al	NNP
10_1101-2021_02_13_429885	299	32	.	.	.
10_1101-2021_02_13_429885	300	1	2012	2012	CD
10_1101-2021_02_13_429885	300	2	.	.	.
10_1101-2021_02_13_429885	301	1	“	"	``
10_1101-2021_02_13_429885	301	2	The	the	DT
10_1101-2021_02_13_429885	301	3	Life	Life	NNP
10_1101-2021_02_13_429885	301	4	History	history	NN
10_1101-2021_02_13_429885	301	5	of	of	IN
10_1101-2021_02_13_429885	301	6	21	21	CD
10_1101-2021_02_13_429885	301	7	Breast	Breast	NNP
10_1101-2021_02_13_429885	301	8	Cancers	Cancers	NNPS
10_1101-2021_02_13_429885	301	9	.	.	.
10_1101-2021_02_13_429885	301	10	”	"	''
10_1101-2021_02_13_429885	301	11	​Cell​	​Cell​	NNP
10_1101-2021_02_13_429885	301	12	149	149	CD
10_1101-2021_02_13_429885	301	13	(	(	-LRB-
10_1101-2021_02_13_429885	301	14	5	5	CD
10_1101-2021_02_13_429885	301	15	)	)	-RRB-
10_1101-2021_02_13_429885	301	16	:	:	:
10_1101-2021_02_13_429885	301	17	994–1007	994–1007	CD
10_1101-2021_02_13_429885	301	18	.	.	.
10_1101-2021_02_13_429885	302	1	https://doi.org/​10.1016/j.cell.2012.04.023	https://doi.org/​10.1016/j.cell.2012.04.023	NNP
10_1101-2021_02_13_429885	302	2	​.	​.	NNP
10_1101-2021_02_13_429885	303	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	303	2	-	-	:
10_1101-2021_02_13_429885	303	3	BY	by	IN
10_1101-2021_02_13_429885	303	4	-	-	HYPH
10_1101-2021_02_13_429885	303	5	NC	NC	NNP
10_1101-2021_02_13_429885	303	6	-	-	HYPH
10_1101-2021_02_13_429885	303	7	ND	ND	NNP
10_1101-2021_02_13_429885	303	8	4.0	4.0	CD
10_1101-2021_02_13_429885	303	9	International	International	NNP
10_1101-2021_02_13_429885	303	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	303	11	under	under	IN
10_1101-2021_02_13_429885	303	12	a	a	DT
10_1101-2021_02_13_429885	303	13	(	(	-LRB-
10_1101-2021_02_13_429885	303	14	which	which	WDT
10_1101-2021_02_13_429885	303	15	was	be	VBD
10_1101-2021_02_13_429885	303	16	not	not	RB
10_1101-2021_02_13_429885	303	17	certified	certify	VBN
10_1101-2021_02_13_429885	303	18	by	by	IN
10_1101-2021_02_13_429885	303	19	peer	peer	NN
10_1101-2021_02_13_429885	303	20	review	review	NN
10_1101-2021_02_13_429885	303	21	)	)	-RRB-
10_1101-2021_02_13_429885	303	22	is	be	VBZ
10_1101-2021_02_13_429885	303	23	the	the	DT
10_1101-2021_02_13_429885	303	24	author	author	NN
10_1101-2021_02_13_429885	303	25	/	/	SYM
10_1101-2021_02_13_429885	303	26	funder	funder	NN
10_1101-2021_02_13_429885	303	27	,	,	,
10_1101-2021_02_13_429885	303	28	who	who	WP
10_1101-2021_02_13_429885	303	29	has	have	VBZ
10_1101-2021_02_13_429885	303	30	granted	grant	VBN
10_1101-2021_02_13_429885	303	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	303	32	a	a	DT
10_1101-2021_02_13_429885	303	33	license	license	NN
10_1101-2021_02_13_429885	303	34	to	to	TO
10_1101-2021_02_13_429885	303	35	display	display	VB
10_1101-2021_02_13_429885	303	36	the	the	DT
10_1101-2021_02_13_429885	303	37	preprint	preprint	NN
10_1101-2021_02_13_429885	303	38	in	in	IN
10_1101-2021_02_13_429885	303	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	303	40	.	.	.
10_1101-2021_02_13_429885	304	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	304	2	is	be	VBZ
10_1101-2021_02_13_429885	304	3	made	make	VBN
10_1101-2021_02_13_429885	304	4	The	the	DT
10_1101-2021_02_13_429885	304	5	copyright	copyright	NN
10_1101-2021_02_13_429885	304	6	holder	holder	NN
10_1101-2021_02_13_429885	304	7	for	for	IN
10_1101-2021_02_13_429885	304	8	this	this	DT
10_1101-2021_02_13_429885	304	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	304	10	version	version	NN
10_1101-2021_02_13_429885	304	11	posted	post	VBD
10_1101-2021_02_13_429885	304	12	February	February	NNP
10_1101-2021_02_13_429885	304	13	13	13	CD
10_1101-2021_02_13_429885	304	14	,	,	,
10_1101-2021_02_13_429885	304	15	2021	2021	CD
10_1101-2021_02_13_429885	304	16	.	.	.
10_1101-2021_02_13_429885	304	17	;	;	:
10_1101-2021_02_13_429885	304	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	304	19	:	:	:
10_1101-2021_02_13_429885	304	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	304	21	preprint	preprint	NN
10_1101-2021_02_13_429885	304	22	http://paperpile.com/b/rqVmzs/A7Vg	http://paperpile.com/b/rqVmzs/A7Vg	NNP
10_1101-2021_02_13_429885	304	23	http://paperpile.com/b/rqVmzs/A7Vg	http://paperpile.com/b/rqVmzs/A7Vg	NNP
10_1101-2021_02_13_429885	304	24	http://paperpile.com/b/rqVmzs/A7Vg	http://paperpile.com/b/rqVmzs/A7Vg	NNP
10_1101-2021_02_13_429885	304	25	http://paperpile.com/b/rqVmzs/A7Vg	http://paperpile.com/b/rqVmzs/A7Vg	NNP
10_1101-2021_02_13_429885	304	26	http://dx.doi.org/10.1016/j.celrep.2014.04.055	http://dx.doi.org/10.1016/j.celrep.2014.04.055	PRP$
10_1101-2021_02_13_429885	304	27	http://paperpile.com/b/rqVmzs/A7Vg	http://paperpile.com/b/rqVmzs/A7Vg	NNP
10_1101-2021_02_13_429885	304	28	http://paperpile.com/b/rqVmzs/vQgD	http://paperpile.com/b/rqVmzs/vQgD	NNP
10_1101-2021_02_13_429885	304	29	http://paperpile.com/b/rqVmzs/vQgD	http://paperpile.com/b/rqVmzs/vQgD	NNP
10_1101-2021_02_13_429885	304	30	http://paperpile.com/b/rqVmzs/vQgD	http://paperpile.com/b/rqVmzs/vQgD	NNP
10_1101-2021_02_13_429885	304	31	http://paperpile.com/b/rqVmzs/vQgD	http://paperpile.com/b/rqVmzs/vQgD	NNP
10_1101-2021_02_13_429885	304	32	http://paperpile.com/b/rqVmzs/vQgD	http://paperpile.com/b/rqVmzs/vQgD	NNP
10_1101-2021_02_13_429885	304	33	http://dx.doi.org/10.1038/s41586-019-1907-7	http://dx.doi.org/10.1038/s41586-019-1907-7	NNP
10_1101-2021_02_13_429885	304	34	http://paperpile.com/b/rqVmzs/vQgD	http://paperpile.com/b/rqVmzs/vQgD	NNP
10_1101-2021_02_13_429885	304	35	http://paperpile.com/b/rqVmzs/Glz6	http://paperpile.com/b/rqvmzs/glz6	UH
10_1101-2021_02_13_429885	304	36	http://paperpile.com/b/rqVmzs/Glz6	http://paperpile.com/b/rqvmzs/glz6	UH
10_1101-2021_02_13_429885	304	37	http://paperpile.com/b/rqVmzs/Glz6	http://paperpile.com/b/rqvmzs/glz6	UH
10_1101-2021_02_13_429885	304	38	http://paperpile.com/b/rqVmzs/Glz6	http://paperpile.com/b/rqvmzs/glz6	UH
10_1101-2021_02_13_429885	304	39	http://paperpile.com/b/rqVmzs/Glz6	http://paperpile.com/b/rqvmzs/glz6	UH
10_1101-2021_02_13_429885	304	40	http://paperpile.com/b/rqVmzs/Glz6	http://paperpile.com/b/rqvmzs/glz6	UH
10_1101-2021_02_13_429885	304	41	http://dx.doi.org/10.1038/nmeth.2642	http://dx.doi.org/10.1038/nmeth.2642	UH
10_1101-2021_02_13_429885	304	42	http://paperpile.com/b/rqVmzs/Glz6	http://paperpile.com/b/rqvmzs/glz6	UH
10_1101-2021_02_13_429885	304	43	http://paperpile.com/b/rqVmzs/Pf2	http://paperpile.com/b/rqVmzs/Pf2	NNP
10_1101-2021_02_13_429885	304	44	t	t	NNP
10_1101-2021_02_13_429885	304	45	http://paperpile.com/b/rqVmzs/Pf2	http://paperpile.com/b/rqVmzs/Pf2	NNP
10_1101-2021_02_13_429885	304	46	t	t	NNP
10_1101-2021_02_13_429885	304	47	http://paperpile.com/b/rqVmzs/Pf2	http://paperpile.com/b/rqVmzs/Pf2	NNP
10_1101-2021_02_13_429885	304	48	t	t	NNP
10_1101-2021_02_13_429885	304	49	http://paperpile.com/b/rqVmzs/Pf2	http://paperpile.com/b/rqVmzs/Pf2	NNP
10_1101-2021_02_13_429885	304	50	t	t	NNP
10_1101-2021_02_13_429885	304	51	http://dx.doi.org/10.1038/nature10762	http://dx.doi.org/10.1038/nature10762	NNP
10_1101-2021_02_13_429885	304	52	http://paperpile.com/b/rqVmzs/Pf2	http://paperpile.com/b/rqVmzs/Pf2	NNP
10_1101-2021_02_13_429885	304	53	t	t	NNP
10_1101-2021_02_13_429885	304	54	http://paperpile.com/b/rqVmzs/CImd	http://paperpile.com/b/rqVmzs/CImd	NNP
10_1101-2021_02_13_429885	304	55	http://paperpile.com/b/rqVmzs/CImd	http://paperpile.com/b/rqVmzs/CImd	NNP
10_1101-2021_02_13_429885	304	56	http://paperpile.com/b/rqVmzs/CImd	http://paperpile.com/b/rqVmzs/CImd	NNP
10_1101-2021_02_13_429885	304	57	http://paperpile.com/b/rqVmzs/CImd	http://paperpile.com/b/rqVmzs/CImd	NNP
10_1101-2021_02_13_429885	304	58	http://paperpile.com/b/rqVmzs/CImd	http://paperpile.com/b/rqVmzs/CImd	VBZ
10_1101-2021_02_13_429885	304	59	http://paperpile.com/b/rqVmzs/CImd	http://paperpile.com/b/rqVmzs/CImd	VBZ
10_1101-2021_02_13_429885	304	60	http://dx.doi.org/10.1056/NEJMoa1616288	http://dx.doi.org/10.1056/nejmoa1616288	IN
10_1101-2021_02_13_429885	304	61	http://paperpile.com/b/rqVmzs/CImd	http://paperpile.com/b/rqVmzs/CImd	NNP
10_1101-2021_02_13_429885	304	62	http://paperpile.com/b/rqVmzs/df7V	http://paperpile.com/b/rqvmzs/df7v	ADD
10_1101-2021_02_13_429885	304	63	http://paperpile.com/b/rqVmzs/df7V	http://paperpile.com/b/rqVmzs/df7V	NNP
10_1101-2021_02_13_429885	304	64	http://paperpile.com/b/rqVmzs/df7V	http://paperpile.com/b/rqVmzs/df7V	NNP
10_1101-2021_02_13_429885	304	65	http://paperpile.com/b/rqVmzs/df7V	http://paperpile.com/b/rqVmzs/df7V	NNP
10_1101-2021_02_13_429885	304	66	http://paperpile.com/b/rqVmzs/df7V	http://paperpile.com/b/rqVmzs/df7V	:
10_1101-2021_02_13_429885	304	67	http://dx.doi.org/10.1101/cshperspect.a027060	http://dx.doi.org/10.1101/cshperspect.a027060	NNP
10_1101-2021_02_13_429885	304	68	http://paperpile.com/b/rqVmzs/df7V	http://paperpile.com/b/rqvmzs/df7v	ADD
10_1101-2021_02_13_429885	304	69	http://paperpile.com/b/rqVmzs/tqeT	http://paperpile.com/b/rqVmzs/tqeT	NNP
10_1101-2021_02_13_429885	304	70	http://paperpile.com/b/rqVmzs/tqeT	http://paperpile.com/b/rqVmzs/tqeT	NNP
10_1101-2021_02_13_429885	304	71	http://paperpile.com/b/rqVmzs/tqeT	http://paperpile.com/b/rqVmzs/tqeT	NNP
10_1101-2021_02_13_429885	304	72	http://paperpile.com/b/rqVmzs/tqeT	http://paperpile.com/b/rqVmzs/tqeT	NNP
10_1101-2021_02_13_429885	304	73	http://paperpile.com/b/rqVmzs/tqeT	http://paperpile.com/b/rqVmzs/tqeT	NNP
10_1101-2021_02_13_429885	304	74	http://paperpile.com/b/rqVmzs/tqeT	http://paperpile.com/b/rqVmzs/tqeT	NNP
10_1101-2021_02_13_429885	304	75	http://dx.doi.org/10.1016/j.cell.2013.01.019	http://dx.doi.org/10.1016/j.cell.2013.01.019	NNP
10_1101-2021_02_13_429885	304	76	http://paperpile.com/b/rqVmzs/tqeT	http://paperpile.com/b/rqVmzs/tqeT	NNP
10_1101-2021_02_13_429885	304	77	http://paperpile.com/b/rqVmzs/SxXl	http://paperpile.com/b/rqVmzs/SxXl	NNS
10_1101-2021_02_13_429885	304	78	http://paperpile.com/b/rqVmzs/SxXl	http://paperpile.com/b/rqVmzs/SxXl	NNS
10_1101-2021_02_13_429885	304	79	http://paperpile.com/b/rqVmzs/SxXl	http://paperpile.com/b/rqVmzs/SxXl	NNS
10_1101-2021_02_13_429885	304	80	http://paperpile.com/b/rqVmzs/SxXl	http://paperpile.com/b/rqVmzs/SxXl	NNS
10_1101-2021_02_13_429885	304	81	http://paperpile.com/b/rqVmzs/SxXl	http://paperpile.com/b/rqVmzs/SxXl	NNP
10_1101-2021_02_13_429885	304	82	http://dx.doi.org/10.1016/j.ccell.2018.11.009	http://dx.doi.org/10.1016/j.ccell.2018.11.009	NNP
10_1101-2021_02_13_429885	304	83	http://paperpile.com/b/rqVmzs/SxXl	http://paperpile.com/b/rqVmzs/SxXl	NNPS
10_1101-2021_02_13_429885	304	84	http://paperpile.com/b/rqVmzs/tMOu	http://paperpile.com/b/rqVmzs/tMOu	NNP
10_1101-2021_02_13_429885	304	85	http://paperpile.com/b/rqVmzs/tMOu	http://paperpile.com/b/rqVmzs/tMOu	NNP
10_1101-2021_02_13_429885	304	86	http://paperpile.com/b/rqVmzs/tMOu	http://paperpile.com/b/rqVmzs/tMOu	NNP
10_1101-2021_02_13_429885	304	87	http://paperpile.com/b/rqVmzs/tMOu	http://paperpile.com/b/rqVmzs/tMOu	NNP
10_1101-2021_02_13_429885	304	88	http://paperpile.com/b/rqVmzs/tMOu	http://paperpile.com/b/rqVmzs/tMOu	NNP
10_1101-2021_02_13_429885	304	89	http://dx.doi.org/10.1038/s41586-019-1913-9	http://dx.doi.org/10.1038/s41586-019-1913-9	NNP
10_1101-2021_02_13_429885	304	90	http://paperpile.com/b/rqVmzs/tMOu	http://paperpile.com/b/rqVmzs/tMOu	NNP
10_1101-2021_02_13_429885	304	91	http://paperpile.com/b/rqVmzs/P1Yv	http://paperpile.com/b/rqVmzs/P1Yv	NNP
10_1101-2021_02_13_429885	304	92	http://paperpile.com/b/rqVmzs/P1Yv	http://paperpile.com/b/rqVmzs/P1Yv	NNP
10_1101-2021_02_13_429885	304	93	http://paperpile.com/b/rqVmzs/P1Yv	http://paperpile.com/b/rqVmzs/P1Yv	NNP
10_1101-2021_02_13_429885	304	94	http://paperpile.com/b/rqVmzs/P1Yv	http://paperpile.com/b/rqVmzs/P1Yv	NNP
10_1101-2021_02_13_429885	304	95	http://paperpile.com/b/rqVmzs/P1Yv	http://paperpile.com/b/rqVmzs/P1Yv	NNP
10_1101-2021_02_13_429885	304	96	http://paperpile.com/b/rqVmzs/P1Yv	http://paperpile.com/b/rqVmzs/P1Yv	NNP
10_1101-2021_02_13_429885	304	97	http://dx.doi.org/10.1038/s41588-018-0179-8	http://dx.doi.org/10.1038/s41588-018-0179-8	NNP
10_1101-2021_02_13_429885	304	98	http://paperpile.com/b/rqVmzs/P1Yv	http://paperpile.com/b/rqVmzs/P1Yv	NNP
10_1101-2021_02_13_429885	304	99	http://paperpile.com/b/rqVmzs/uG2X	http://paperpile.com/b/rqVmzs/uG2X	NNP
10_1101-2021_02_13_429885	304	100	http://paperpile.com/b/rqVmzs/uG2X	http://paperpile.com/b/rqVmzs/uG2X	NNP
10_1101-2021_02_13_429885	304	101	http://paperpile.com/b/rqVmzs/uG2X	http://paperpile.com/b/rqVmzs/uG2X	NNP
10_1101-2021_02_13_429885	304	102	http://paperpile.com/b/rqVmzs/uG2X	http://paperpile.com/b/rqVmzs/uG2X	NNP
10_1101-2021_02_13_429885	304	103	http://paperpile.com/b/rqVmzs/uG2X	http://paperpile.com/b/rqVmzs/uG2X	NNP
10_1101-2021_02_13_429885	304	104	http://paperpile.com/b/rqVmzs/uG2X	http://paperpile.com/b/rqVmzs/uG2X	NNP
10_1101-2021_02_13_429885	304	105	http://dx.doi.org/10.1126/science.aau3879	http://dx.doi.org/10.1126/science.aau3879	NNP
10_1101-2021_02_13_429885	304	106	http://paperpile.com/b/rqVmzs/uG2X	http://paperpile.com/b/rqVmzs/uG2X	NNP
10_1101-2021_02_13_429885	304	107	http://paperpile.com/b/rqVmzs/4mqr	http://paperpile.com/b/rqVmzs/4mqr	NNP
10_1101-2021_02_13_429885	304	108	http://paperpile.com/b/rqVmzs/4mqr	http://paperpile.com/b/rqVmzs/4mqr	''
10_1101-2021_02_13_429885	304	109	http://paperpile.com/b/rqVmzs/4mqr	http://paperpile.com/b/rqVmzs/4mqr	``
10_1101-2021_02_13_429885	304	110	http://paperpile.com/b/rqVmzs/4mqr	http://paperpile.com/b/rqVmzs/4mqr	``
10_1101-2021_02_13_429885	304	111	http://paperpile.com/b/rqVmzs/4mqr	http://paperpile.com/b/rqVmzs/4mqr	``
10_1101-2021_02_13_429885	304	112	http://paperpile.com/b/rqVmzs/4mqr	http://paperpile.com/b/rqVmzs/4mqr	VBZ
10_1101-2021_02_13_429885	304	113	http://dx.doi.org/10.1126/science.aaa6806	http://dx.doi.org/10.1126/science.aaa6806	NNP
10_1101-2021_02_13_429885	304	114	http://paperpile.com/b/rqVmzs/4mqr	http://paperpile.com/b/rqVmzs/4mqr	''
10_1101-2021_02_13_429885	304	115	http://paperpile.com/b/rqVmzs/ZoHM	http://paperpile.com/b/rqvmzs/zohm	JJ
10_1101-2021_02_13_429885	304	116	http://paperpile.com/b/rqVmzs/ZoHM	http://paperpile.com/b/rqvmzs/zohm	UH
10_1101-2021_02_13_429885	304	117	http://paperpile.com/b/rqVmzs/ZoHM	http://paperpile.com/b/rqvmzs/zohm	UH
10_1101-2021_02_13_429885	304	118	http://paperpile.com/b/rqVmzs/ZoHM	http://paperpile.com/b/rqvmzs/zohm	UH
10_1101-2021_02_13_429885	304	119	http://paperpile.com/b/rqVmzs/ZoHM	http://paperpile.com/b/rqvmzs/zohm	FW
10_1101-2021_02_13_429885	304	120	http://dx.doi.org/10.1016/j.ccell.2014.12.001	http://dx.doi.org/10.1016/j.ccell.2014.12.001	FW
10_1101-2021_02_13_429885	304	121	http://paperpile.com/b/rqVmzs/ZoHM	http://paperpile.com/b/rqVmzs/ZoHM	NNP
10_1101-2021_02_13_429885	304	122	http://paperpile.com/b/rqVmzs/5LH8	http://paperpile.com/b/rqVmzs/5LH8	NNP
10_1101-2021_02_13_429885	304	123	http://paperpile.com/b/rqVmzs/5LH8	http://paperpile.com/b/rqVmzs/5LH8	NNP
10_1101-2021_02_13_429885	304	124	http://paperpile.com/b/rqVmzs/5LH8	http://paperpile.com/b/rqVmzs/5LH8	NNP
10_1101-2021_02_13_429885	304	125	http://paperpile.com/b/rqVmzs/5LH8	http://paperpile.com/b/rqVmzs/5LH8	NNP
10_1101-2021_02_13_429885	304	126	http://dx.doi.org/10.1016/j.cell.2017.01.018	http://dx.doi.org/10.1016/j.cell.2017.01.018	NNP
10_1101-2021_02_13_429885	304	127	http://paperpile.com/b/rqVmzs/5LH8	http://paperpile.com/b/rqVmzs/5LH8	NNP
10_1101-2021_02_13_429885	304	128	http://paperpile.com/b/rqVmzs/bHGV	http://paperpile.com/b/rqvmzs/bhgv	UH
10_1101-2021_02_13_429885	304	129	http://paperpile.com/b/rqVmzs/bHGV	http://paperpile.com/b/rqvmzs/bhgv	UH
10_1101-2021_02_13_429885	304	130	http://paperpile.com/b/rqVmzs/bHGV	http://paperpile.com/b/rqvmzs/bhgv	UH
10_1101-2021_02_13_429885	304	131	http://paperpile.com/b/rqVmzs/bHGV	http://paperpile.com/b/rqvmzs/bhgv	UH
10_1101-2021_02_13_429885	304	132	http://paperpile.com/b/rqVmzs/bHGV	http://paperpile.com/b/rqvmzs/bhgv	UH
10_1101-2021_02_13_429885	304	133	http://dx.doi.org/10.1016/j.cell.2012.04.023	http://dx.doi.org/10.1016/j.cell.2012.04.023	NNP
10_1101-2021_02_13_429885	304	134	http://paperpile.com/b/rqVmzs/bHGV	http://paperpile.com/b/rqvmzs/bhgv	UH
10_1101-2021_02_13_429885	304	135	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	NNP
10_1101-2021_02_13_429885	304	136	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	304	137	Househam	Househam	NNP
10_1101-2021_02_13_429885	304	138	et	et	FW
10_1101-2021_02_13_429885	304	139	al	al	NNP
10_1101-2021_02_13_429885	304	140	.	.	.
10_1101-2021_02_13_429885	305	1	A	a	DT
10_1101-2021_02_13_429885	305	2	fully	fully	RB
10_1101-2021_02_13_429885	305	3	automated	automate	VBN
10_1101-2021_02_13_429885	305	4	approach	approach	NN
10_1101-2021_02_13_429885	305	5	for	for	IN
10_1101-2021_02_13_429885	305	6	quality	quality	NN
10_1101-2021_02_13_429885	305	7	control	control	NN
10_1101-2021_02_13_429885	305	8	of	of	IN
10_1101-2021_02_13_429885	305	9	cancer	cancer	NN
10_1101-2021_02_13_429885	305	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	305	11	in	in	IN
10_1101-2021_02_13_429885	305	12	the	the	DT
10_1101-2021_02_13_429885	305	13	era	era	NN
10_1101-2021_02_13_429885	305	14	of	of	IN
10_1101-2021_02_13_429885	305	15	high	high	JJ
10_1101-2021_02_13_429885	305	16	-	-	HYPH
10_1101-2021_02_13_429885	305	17	resolution	resolution	NN
10_1101-2021_02_13_429885	305	18	whole	whole	JJ
10_1101-2021_02_13_429885	305	19	genome	genome	JJ
10_1101-2021_02_13_429885	305	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	305	21	.	.	.
10_1101-2021_02_13_429885	306	1	Priestley	Priestley	NNP
10_1101-2021_02_13_429885	306	2	,	,	,
10_1101-2021_02_13_429885	306	3	Peter	Peter	NNP
10_1101-2021_02_13_429885	306	4	,	,	,
10_1101-2021_02_13_429885	306	5	Jonathan	Jonathan	NNP
10_1101-2021_02_13_429885	306	6	Baber	Baber	NNP
10_1101-2021_02_13_429885	306	7	,	,	,
10_1101-2021_02_13_429885	306	8	Martijn	Martijn	NNP
10_1101-2021_02_13_429885	306	9	P.	P.	NNP
10_1101-2021_02_13_429885	306	10	Lolkema	Lolkema	NNP
10_1101-2021_02_13_429885	306	11	,	,	,
10_1101-2021_02_13_429885	306	12	Neeltje	Neeltje	NNP
10_1101-2021_02_13_429885	306	13	Steeghs	Steeghs	NNP
10_1101-2021_02_13_429885	306	14	,	,	,
10_1101-2021_02_13_429885	306	15	Ewart	Ewart	NNP
10_1101-2021_02_13_429885	306	16	de	de	FW
10_1101-2021_02_13_429885	306	17	Bruijn	Bruijn	NNP
10_1101-2021_02_13_429885	306	18	,	,	,
10_1101-2021_02_13_429885	306	19	Charles	Charles	NNP
10_1101-2021_02_13_429885	306	20	Shale	Shale	NNP
10_1101-2021_02_13_429885	306	21	,	,	,
10_1101-2021_02_13_429885	306	22	Korneel	Korneel	NNP
10_1101-2021_02_13_429885	306	23	Duyvesteyn	Duyvesteyn	NNP
10_1101-2021_02_13_429885	306	24	,	,	,
10_1101-2021_02_13_429885	306	25	et	et	NNP
10_1101-2021_02_13_429885	306	26	al	al	NNP
10_1101-2021_02_13_429885	306	27	.	.	.
10_1101-2021_02_13_429885	307	1	2019	2019	CD
10_1101-2021_02_13_429885	307	2	.	.	.
10_1101-2021_02_13_429885	308	1	“	"	``
10_1101-2021_02_13_429885	308	2	Pan	Pan	NNP
10_1101-2021_02_13_429885	308	3	-	-	NNP
10_1101-2021_02_13_429885	308	4	Cancer	cancer	JJ
10_1101-2021_02_13_429885	308	5	Whole	whole	JJ
10_1101-2021_02_13_429885	308	6	-	-	HYPH
10_1101-2021_02_13_429885	308	7	Genome	genome	JJ
10_1101-2021_02_13_429885	308	8	Analyses	analysis	NNS
10_1101-2021_02_13_429885	308	9	of	of	IN
10_1101-2021_02_13_429885	308	10	Metastatic	metastatic	JJ
10_1101-2021_02_13_429885	308	11	Solid	Solid	NNP
10_1101-2021_02_13_429885	308	12	Tumours	Tumours	NNPS
10_1101-2021_02_13_429885	308	13	.	.	.
10_1101-2021_02_13_429885	308	14	”	"	''
10_1101-2021_02_13_429885	308	15	​Nature​	​Nature​	NNP
10_1101-2021_02_13_429885	308	16	575	575	CD
10_1101-2021_02_13_429885	308	17	(	(	-LRB-
10_1101-2021_02_13_429885	308	18	7781	7781	CD
10_1101-2021_02_13_429885	308	19	)	)	-RRB-
10_1101-2021_02_13_429885	308	20	:	:	:
10_1101-2021_02_13_429885	308	21	210–16	210–16	CD
10_1101-2021_02_13_429885	308	22	.	.	.
10_1101-2021_02_13_429885	309	1	https://doi.org/​10.1038/s41586-019-1689-y​.	https://doi.org/​10.1038/s41586-019-1689-y​.	LS
10_1101-2021_02_13_429885	310	1	Turajlic	Turajlic	NNP
10_1101-2021_02_13_429885	310	2	,	,	,
10_1101-2021_02_13_429885	310	3	Samra	Samra	NNP
10_1101-2021_02_13_429885	310	4	,	,	,
10_1101-2021_02_13_429885	310	5	Hang	Hang	NNP
10_1101-2021_02_13_429885	310	6	Xu	Xu	NNP
10_1101-2021_02_13_429885	310	7	,	,	,
10_1101-2021_02_13_429885	310	8	Kevin	Kevin	NNP
10_1101-2021_02_13_429885	310	9	Litchfield	Litchfield	NNP
10_1101-2021_02_13_429885	310	10	,	,	,
10_1101-2021_02_13_429885	310	11	Andrew	Andrew	NNP
10_1101-2021_02_13_429885	310	12	Rowan	Rowan	NNP
10_1101-2021_02_13_429885	310	13	,	,	,
10_1101-2021_02_13_429885	310	14	Stuart	Stuart	NNP
10_1101-2021_02_13_429885	310	15	Horswell	Horswell	NNP
10_1101-2021_02_13_429885	310	16	,	,	,
10_1101-2021_02_13_429885	310	17	Tim	Tim	NNP
10_1101-2021_02_13_429885	310	18	Chambers	Chambers	NNP
10_1101-2021_02_13_429885	310	19	,	,	,
10_1101-2021_02_13_429885	310	20	Tim	Tim	NNP
10_1101-2021_02_13_429885	310	21	O’Brien	O’Brien	NNP
10_1101-2021_02_13_429885	310	22	,	,	,
10_1101-2021_02_13_429885	310	23	et	et	NNP
10_1101-2021_02_13_429885	310	24	al	al	NNP
10_1101-2021_02_13_429885	310	25	.	.	.
10_1101-2021_02_13_429885	311	1	2018	2018	CD
10_1101-2021_02_13_429885	311	2	.	.	.
10_1101-2021_02_13_429885	312	1	“	"	``
10_1101-2021_02_13_429885	312	2	Deterministic	Deterministic	NNP
10_1101-2021_02_13_429885	312	3	Evolutionary	Evolutionary	NNP
10_1101-2021_02_13_429885	312	4	Trajectories	Trajectories	NNPS
10_1101-2021_02_13_429885	312	5	Influence	Influence	NNP
10_1101-2021_02_13_429885	312	6	Primary	Primary	NNP
10_1101-2021_02_13_429885	312	7	Tumor	Tumor	NNP
10_1101-2021_02_13_429885	312	8	Growth	growth	NN
10_1101-2021_02_13_429885	312	9	:	:	:
10_1101-2021_02_13_429885	312	10	TRACERx	TRACERx	NNPS
10_1101-2021_02_13_429885	312	11	Renal	renal	JJ
10_1101-2021_02_13_429885	312	12	.	.	.
10_1101-2021_02_13_429885	312	13	”	"	''
10_1101-2021_02_13_429885	312	14	​Cell​	​Cell​	NNP
10_1101-2021_02_13_429885	312	15	173	173	CD
10_1101-2021_02_13_429885	312	16	(	(	-LRB-
10_1101-2021_02_13_429885	312	17	3	3	CD
10_1101-2021_02_13_429885	312	18	)	)	-RRB-
10_1101-2021_02_13_429885	312	19	:	:	:
10_1101-2021_02_13_429885	312	20	595–610.e11	595–610.e11	LS
10_1101-2021_02_13_429885	312	21	.	.	.
10_1101-2021_02_13_429885	313	1	https://doi.org/​10.1016/j.cell.2018.03.043	https://doi.org/​10.1016/j.cell.2018.03.043	NNS
10_1101-2021_02_13_429885	313	2	​.	​.	JJ
10_1101-2021_02_13_429885	314	1	Turnbull	Turnbull	NNP
10_1101-2021_02_13_429885	314	2	,	,	,
10_1101-2021_02_13_429885	314	3	Clare	Clare	NNP
10_1101-2021_02_13_429885	314	4	,	,	,
10_1101-2021_02_13_429885	314	5	Richard	Richard	NNP
10_1101-2021_02_13_429885	314	6	H.	H.	NNP
10_1101-2021_02_13_429885	314	7	Scott	Scott	NNP
10_1101-2021_02_13_429885	314	8	,	,	,
10_1101-2021_02_13_429885	314	9	Ellen	Ellen	NNP
10_1101-2021_02_13_429885	314	10	Thomas	Thomas	NNP
10_1101-2021_02_13_429885	314	11	,	,	,
10_1101-2021_02_13_429885	314	12	Louise	Louise	NNP
10_1101-2021_02_13_429885	314	13	Jones	Jones	NNP
10_1101-2021_02_13_429885	314	14	,	,	,
10_1101-2021_02_13_429885	314	15	Nirupa	Nirupa	NNP
10_1101-2021_02_13_429885	314	16	Murugaesu	Murugaesu	NNP
10_1101-2021_02_13_429885	314	17	,	,	,
10_1101-2021_02_13_429885	314	18	Freya	Freya	NNP
10_1101-2021_02_13_429885	314	19	Boardman	Boardman	NNP
10_1101-2021_02_13_429885	314	20	Pretty	Pretty	NNP
10_1101-2021_02_13_429885	314	21	,	,	,
10_1101-2021_02_13_429885	314	22	Dina	Dina	NNP
10_1101-2021_02_13_429885	314	23	Halai	Halai	NNP
10_1101-2021_02_13_429885	314	24	,	,	,
10_1101-2021_02_13_429885	314	25	et	et	NNP
10_1101-2021_02_13_429885	314	26	al	al	NNP
10_1101-2021_02_13_429885	314	27	.	.	.
10_1101-2021_02_13_429885	315	1	2018	2018	CD
10_1101-2021_02_13_429885	315	2	.	.	.
10_1101-2021_02_13_429885	316	1	“	"	``
10_1101-2021_02_13_429885	316	2	The	the	DT
10_1101-2021_02_13_429885	316	3	100	100	CD
10_1101-2021_02_13_429885	316	4	000	000	CD
10_1101-2021_02_13_429885	316	5	Genomes	Genomes	NNP
10_1101-2021_02_13_429885	316	6	Project	Project	NNP
10_1101-2021_02_13_429885	316	7	:	:	:
10_1101-2021_02_13_429885	316	8	Bringing	bring	VBG
10_1101-2021_02_13_429885	316	9	Whole	whole	JJ
10_1101-2021_02_13_429885	316	10	Genome	Genome	NNP
10_1101-2021_02_13_429885	316	11	Sequencing	sequencing	NN
10_1101-2021_02_13_429885	316	12	to	to	IN
10_1101-2021_02_13_429885	316	13	the	the	DT
10_1101-2021_02_13_429885	316	14	NHS	NHS	NNP
10_1101-2021_02_13_429885	316	15	.	.	.
10_1101-2021_02_13_429885	316	16	”	"	''
10_1101-2021_02_13_429885	316	17	​BMJ	​BMJ	NNP
10_1101-2021_02_13_429885	316	18	​	​	NNP
10_1101-2021_02_13_429885	316	19	361	361	CD
10_1101-2021_02_13_429885	316	20	(	(	-LRB-
10_1101-2021_02_13_429885	316	21	April	April	NNP
10_1101-2021_02_13_429885	316	22	)	)	-RRB-
10_1101-2021_02_13_429885	316	23	:	:	:
10_1101-2021_02_13_429885	316	24	k1687	k1687	NNP
10_1101-2021_02_13_429885	316	25	.	.	.
10_1101-2021_02_13_429885	317	1	https://doi.org/​10.1136/bmj.k1687	https://doi.org/​10.1136/bmj.k1687	NNP
10_1101-2021_02_13_429885	317	2	​.	​.	NNP
10_1101-2021_02_13_429885	318	1	Van	Van	NNP
10_1101-2021_02_13_429885	318	2	Loo	Loo	NNP
10_1101-2021_02_13_429885	318	3	,	,	,
10_1101-2021_02_13_429885	318	4	Peter	Peter	NNP
10_1101-2021_02_13_429885	318	5	,	,	,
10_1101-2021_02_13_429885	318	6	Silje	Silje	NNP
10_1101-2021_02_13_429885	318	7	H.	H.	NNP
10_1101-2021_02_13_429885	318	8	Nordgard	Nordgard	NNP
10_1101-2021_02_13_429885	318	9	,	,	,
10_1101-2021_02_13_429885	318	10	Ole	Ole	NNP
10_1101-2021_02_13_429885	318	11	Christian	Christian	NNP
10_1101-2021_02_13_429885	318	12	Lingjærde	Lingjærde	NNP
10_1101-2021_02_13_429885	318	13	,	,	,
10_1101-2021_02_13_429885	318	14	Hege	Hege	NNP
10_1101-2021_02_13_429885	318	15	G.	G.	NNP
10_1101-2021_02_13_429885	318	16	Russnes	Russnes	NNP
10_1101-2021_02_13_429885	318	17	,	,	,
10_1101-2021_02_13_429885	318	18	Inga	Inga	NNP
10_1101-2021_02_13_429885	318	19	H.	H.	NNP
10_1101-2021_02_13_429885	318	20	Rye	Rye	NNP
10_1101-2021_02_13_429885	318	21	,	,	,
10_1101-2021_02_13_429885	318	22	Wei	Wei	NNP
10_1101-2021_02_13_429885	318	23	Sun	Sun	NNP
10_1101-2021_02_13_429885	318	24	,	,	,
10_1101-2021_02_13_429885	318	25	Victor	Victor	NNP
10_1101-2021_02_13_429885	318	26	J.	J.	NNP
10_1101-2021_02_13_429885	318	27	Weigman	Weigman	NNP
10_1101-2021_02_13_429885	318	28	,	,	,
10_1101-2021_02_13_429885	318	29	et	et	NNP
10_1101-2021_02_13_429885	318	30	al	al	NNP
10_1101-2021_02_13_429885	318	31	.	.	.
10_1101-2021_02_13_429885	319	1	2010	2010	CD
10_1101-2021_02_13_429885	319	2	.	.	.
10_1101-2021_02_13_429885	320	1	“	"	``
10_1101-2021_02_13_429885	320	2	Allele	Allele	NNP
10_1101-2021_02_13_429885	320	3	-	-	HYPH
10_1101-2021_02_13_429885	320	4	Specific	Specific	NNP
10_1101-2021_02_13_429885	320	5	Copy	Copy	NNP
10_1101-2021_02_13_429885	320	6	Number	Number	NNP
10_1101-2021_02_13_429885	320	7	Analysis	Analysis	NNP
10_1101-2021_02_13_429885	320	8	of	of	IN
10_1101-2021_02_13_429885	320	9	Tumors	Tumors	NNPS
10_1101-2021_02_13_429885	320	10	.	.	.
10_1101-2021_02_13_429885	320	11	”	"	''
10_1101-2021_02_13_429885	320	12	Proceedings	proceeding	NNS
10_1101-2021_02_13_429885	320	13	of	of	IN
10_1101-2021_02_13_429885	320	14	the	the	DT
10_1101-2021_02_13_429885	320	15	National	National	NNP
10_1101-2021_02_13_429885	320	16	Academy	Academy	NNP
10_1101-2021_02_13_429885	320	17	of	of	IN
10_1101-2021_02_13_429885	320	18	Sciences	Sciences	NNPS
10_1101-2021_02_13_429885	320	19	of	of	IN
10_1101-2021_02_13_429885	320	20	the	the	DT
10_1101-2021_02_13_429885	320	21	United	United	NNP
10_1101-2021_02_13_429885	320	22	States	States	NNP
10_1101-2021_02_13_429885	320	23	of	of	IN
10_1101-2021_02_13_429885	320	24	America​	America​	NNP
10_1101-2021_02_13_429885	320	25	107	107	CD
10_1101-2021_02_13_429885	320	26	(	(	-LRB-
10_1101-2021_02_13_429885	320	27	39	39	CD
10_1101-2021_02_13_429885	320	28	)	)	-RRB-
10_1101-2021_02_13_429885	320	29	:	:	:
10_1101-2021_02_13_429885	320	30	16910–15	16910–15	LS
10_1101-2021_02_13_429885	320	31	.	.	.
10_1101-2021_02_13_429885	321	1	https://doi.org/​10.1073/pnas.1009843107	https://doi.org/​10.1073/pnas.1009843107	VB
10_1101-2021_02_13_429885	321	2	​.	​.	JJ
10_1101-2021_02_13_429885	322	1	Watkins	Watkins	NNP
10_1101-2021_02_13_429885	322	2	,	,	,
10_1101-2021_02_13_429885	322	3	Thomas	Thomas	NNP
10_1101-2021_02_13_429885	322	4	B.	B.	NNP
10_1101-2021_02_13_429885	322	5	K.	K.	NNP
10_1101-2021_02_13_429885	322	6	,	,	,
10_1101-2021_02_13_429885	322	7	Emilia	Emilia	NNP
10_1101-2021_02_13_429885	322	8	L.	L.	NNP
10_1101-2021_02_13_429885	322	9	Lim	Lim	NNP
10_1101-2021_02_13_429885	322	10	,	,	,
10_1101-2021_02_13_429885	322	11	Marina	Marina	NNP
10_1101-2021_02_13_429885	322	12	Petkovic	Petkovic	NNP
10_1101-2021_02_13_429885	322	13	,	,	,
10_1101-2021_02_13_429885	322	14	Sergi	Sergi	NNP
10_1101-2021_02_13_429885	322	15	Elizalde	Elizalde	NNP
10_1101-2021_02_13_429885	322	16	,	,	,
10_1101-2021_02_13_429885	322	17	Nicolai	Nicolai	NNP
10_1101-2021_02_13_429885	322	18	J.	J.	NNP
10_1101-2021_02_13_429885	322	19	Birkbak	Birkbak	NNP
10_1101-2021_02_13_429885	322	20	,	,	,
10_1101-2021_02_13_429885	322	21	Gareth	Gareth	NNP
10_1101-2021_02_13_429885	322	22	A.	A.	NNP
10_1101-2021_02_13_429885	322	23	Wilson	Wilson	NNP
10_1101-2021_02_13_429885	322	24	,	,	,
10_1101-2021_02_13_429885	322	25	David	David	NNP
10_1101-2021_02_13_429885	322	26	A.	a.	NN
10_1101-2021_02_13_429885	322	27	Moore	Moore	NNP
10_1101-2021_02_13_429885	322	28	,	,	,
10_1101-2021_02_13_429885	322	29	et	et	NNP
10_1101-2021_02_13_429885	322	30	al	al	NNP
10_1101-2021_02_13_429885	322	31	.	.	.
10_1101-2021_02_13_429885	323	1	11	11	CD
10_1101-2021_02_13_429885	323	2	2020	2020	CD
10_1101-2021_02_13_429885	323	3	.	.	.
10_1101-2021_02_13_429885	324	1	“	"	``
10_1101-2021_02_13_429885	324	2	Pervasive	Pervasive	NNP
10_1101-2021_02_13_429885	324	3	Chromosomal	Chromosomal	NNP
10_1101-2021_02_13_429885	324	4	Instability	Instability	NNP
10_1101-2021_02_13_429885	324	5	and	and	CC
10_1101-2021_02_13_429885	324	6	Karyotype	Karyotype	NNP
10_1101-2021_02_13_429885	324	7	Order	Order	NNP
10_1101-2021_02_13_429885	324	8	in	in	IN
10_1101-2021_02_13_429885	324	9	Tumour	Tumour	NNP
10_1101-2021_02_13_429885	324	10	Evolution	Evolution	NNP
10_1101-2021_02_13_429885	324	11	.	.	.
10_1101-2021_02_13_429885	324	12	”	"	''
10_1101-2021_02_13_429885	324	13	​Nature​	​Nature​	NNP
10_1101-2021_02_13_429885	324	14	587	587	CD
10_1101-2021_02_13_429885	324	15	(	(	-LRB-
10_1101-2021_02_13_429885	324	16	7832	7832	CD
10_1101-2021_02_13_429885	324	17	)	)	-RRB-
10_1101-2021_02_13_429885	324	18	:	:	:
10_1101-2021_02_13_429885	324	19	126–32	126–32	CD
10_1101-2021_02_13_429885	324	20	.	.	.
10_1101-2021_02_13_429885	325	1	https://doi.org/​10.1038/s41586-020-2698-6	https://doi.org/​10.1038/s41586-020-2698-6	ADD
10_1101-2021_02_13_429885	325	2	​.	​.	CD
10_1101-2021_02_13_429885	326	1	Zaccaria	Zaccaria	NNP
10_1101-2021_02_13_429885	326	2	,	,	,
10_1101-2021_02_13_429885	326	3	Simone	Simone	NNP
10_1101-2021_02_13_429885	326	4	,	,	,
10_1101-2021_02_13_429885	326	5	and	and	CC
10_1101-2021_02_13_429885	326	6	Benjamin	Benjamin	NNP
10_1101-2021_02_13_429885	326	7	J.	J.	NNP
10_1101-2021_02_13_429885	326	8	Raphael	Raphael	NNP
10_1101-2021_02_13_429885	326	9	.	.	.
10_1101-2021_02_13_429885	327	1	2020	2020	CD
10_1101-2021_02_13_429885	327	2	.	.	.
10_1101-2021_02_13_429885	328	1	“	"	``
10_1101-2021_02_13_429885	328	2	Accurate	accurate	JJ
10_1101-2021_02_13_429885	328	3	Quantification	quantification	NN
10_1101-2021_02_13_429885	328	4	of	of	IN
10_1101-2021_02_13_429885	328	5	Copy	Copy	NNP
10_1101-2021_02_13_429885	328	6	-	-	HYPH
10_1101-2021_02_13_429885	328	7	Number	Number	NNP
10_1101-2021_02_13_429885	328	8	Aberrations	Aberrations	NNPS
10_1101-2021_02_13_429885	328	9	and	and	CC
10_1101-2021_02_13_429885	328	10	Whole	whole	JJ
10_1101-2021_02_13_429885	328	11	-	-	HYPH
10_1101-2021_02_13_429885	328	12	Genome	genome	JJ
10_1101-2021_02_13_429885	328	13	Duplications	Duplications	NNPS
10_1101-2021_02_13_429885	328	14	in	in	IN
10_1101-2021_02_13_429885	328	15	Multi	Multi	NNP
10_1101-2021_02_13_429885	328	16	-	-	HYPH
10_1101-2021_02_13_429885	328	17	Sample	Sample	NNP
10_1101-2021_02_13_429885	328	18	Tumor	Tumor	NNP
10_1101-2021_02_13_429885	328	19	Sequencing	Sequencing	NNP
10_1101-2021_02_13_429885	328	20	Data	Data	NNPS
10_1101-2021_02_13_429885	328	21	.	.	.
10_1101-2021_02_13_429885	328	22	”	"	''
10_1101-2021_02_13_429885	328	23	Nature	Nature	NNP
10_1101-2021_02_13_429885	328	24	Communications​	Communications​	NNP
10_1101-2021_02_13_429885	328	25	11	11	CD
10_1101-2021_02_13_429885	328	26	(	(	-LRB-
10_1101-2021_02_13_429885	328	27	1	1	CD
10_1101-2021_02_13_429885	328	28	)	)	-RRB-
10_1101-2021_02_13_429885	328	29	:	:	:
10_1101-2021_02_13_429885	328	30	4301	4301	CD
10_1101-2021_02_13_429885	328	31	.	.	.
10_1101-2021_02_13_429885	328	32	https://doi.org/​10.1038/s41467-020-17967-y​.	https://doi.org/​10.1038/s41467-020-17967-y​.	CD
10_1101-2021_02_13_429885	329	1	Data	Data	NNP
10_1101-2021_02_13_429885	329	2	Availability	Availability	NNP
10_1101-2021_02_13_429885	329	3	Multiregion	multiregion	NN
10_1101-2021_02_13_429885	329	4	​colorectal	​colorectal	,
10_1101-2021_02_13_429885	329	5	cancer	cancer	NN
10_1101-2021_02_13_429885	329	6	data	datum	NNS
10_1101-2021_02_13_429885	329	7	is	be	VBZ
10_1101-2021_02_13_429885	329	8	deposited	deposit	VBN
10_1101-2021_02_13_429885	329	9	in	in	IN
10_1101-2021_02_13_429885	329	10	EGA	EGA	NNP
10_1101-2021_02_13_429885	329	11	under	under	IN
10_1101-2021_02_13_429885	329	12	accession	accession	NN
10_1101-2021_02_13_429885	329	13	number	number	NN
10_1101-2021_02_13_429885	329	14	EGAS00001003066	EGAS00001003066	NNP
10_1101-2021_02_13_429885	329	15	.	.	.
10_1101-2021_02_13_429885	330	1	PCAWG	pcawg	NN
10_1101-2021_02_13_429885	330	2	calls	call	NNS
10_1101-2021_02_13_429885	330	3	are	be	VBP
10_1101-2021_02_13_429885	330	4	publicly	publicly	RB
10_1101-2021_02_13_429885	330	5	available	available	JJ
10_1101-2021_02_13_429885	330	6	at	at	IN
10_1101-2021_02_13_429885	330	7	(	(	-LRB-
10_1101-2021_02_13_429885	330	8	​https://dcc.icgc.org/​	​https://dcc.icgc.org/​	NNP
10_1101-2021_02_13_429885	330	9	)	)	-RRB-
10_1101-2021_02_13_429885	330	10	,	,	,
10_1101-2021_02_13_429885	330	11	the	the	DT
10_1101-2021_02_13_429885	330	12	ICGC	ICGC	NNP
10_1101-2021_02_13_429885	330	13	Data	Data	NNP
10_1101-2021_02_13_429885	330	14	Portal	Portal	NNP
10_1101-2021_02_13_429885	330	15	.	.	.
10_1101-2021_02_13_429885	331	1	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	331	2	is	be	VBZ
10_1101-2021_02_13_429885	331	3	implemented	implement	VBN
10_1101-2021_02_13_429885	331	4	as	as	IN
10_1101-2021_02_13_429885	331	5	an	an	DT
10_1101-2021_02_13_429885	331	6	open	open	JJ
10_1101-2021_02_13_429885	331	7	source	source	NN
10_1101-2021_02_13_429885	331	8	R	r	NN
10_1101-2021_02_13_429885	331	9	package	package	NN
10_1101-2021_02_13_429885	331	10	that	that	WDT
10_1101-2021_02_13_429885	331	11	is	be	VBZ
10_1101-2021_02_13_429885	331	12	hosted	host	VBN
10_1101-2021_02_13_429885	331	13	at	at	IN
10_1101-2021_02_13_429885	331	14	the	the	DT
10_1101-2021_02_13_429885	331	15	GitHub	GitHub	NNP
10_1101-2021_02_13_429885	331	16	space	space	NN
10_1101-2021_02_13_429885	331	17	of	of	IN
10_1101-2021_02_13_429885	331	18	the	the	DT
10_1101-2021_02_13_429885	331	19	Caravagna	Caravagna	NNP
10_1101-2021_02_13_429885	331	20	Lab	Lab	NNP
10_1101-2021_02_13_429885	331	21	https://caravagnalab.github.io/CNAqc/​.	https://caravagnalab.github.io/cnaqc/​.	NN
10_1101-2021_02_13_429885	332	1	The	the	DT
10_1101-2021_02_13_429885	332	2	tool	tool	NN
10_1101-2021_02_13_429885	332	3	webpage	webpage	NN
10_1101-2021_02_13_429885	332	4	contains	contain	VBZ
10_1101-2021_02_13_429885	332	5	RMarkdown	RMarkdown	NNP
10_1101-2021_02_13_429885	332	6	tutorial	tutorial	JJ
10_1101-2021_02_13_429885	332	7	vignettes	vignette	NNS
10_1101-2021_02_13_429885	332	8	to	to	TO
10_1101-2021_02_13_429885	332	9	run	run	VB
10_1101-2021_02_13_429885	332	10	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	332	11	analysis	analysis	NN
10_1101-2021_02_13_429885	332	12	of	of	IN
10_1101-2021_02_13_429885	332	13	a	a	DT
10_1101-2021_02_13_429885	332	14	generic	generic	JJ
10_1101-2021_02_13_429885	332	15	dataset	dataset	NN
10_1101-2021_02_13_429885	332	16	,	,	,
10_1101-2021_02_13_429885	332	17	as	as	RB
10_1101-2021_02_13_429885	332	18	well	well	RB
10_1101-2021_02_13_429885	332	19	as	as	IN
10_1101-2021_02_13_429885	332	20	documents	document	NNS
10_1101-2021_02_13_429885	332	21	that	that	WDT
10_1101-2021_02_13_429885	332	22	explain	explain	VBP
10_1101-2021_02_13_429885	332	23	visualisation	visualisation	NN
10_1101-2021_02_13_429885	332	24	and	and	CC
10_1101-2021_02_13_429885	332	25	parameterizations	parameterization	NNS
10_1101-2021_02_13_429885	332	26	of	of	IN
10_1101-2021_02_13_429885	332	27	the	the	DT
10_1101-2021_02_13_429885	332	28	execution	execution	NN
10_1101-2021_02_13_429885	332	29	.	.	.
10_1101-2021_02_13_429885	333	1	All	all	DT
10_1101-2021_02_13_429885	333	2	analyses	analysis	NNS
10_1101-2021_02_13_429885	333	3	in	in	IN
10_1101-2021_02_13_429885	333	4	this	this	DT
10_1101-2021_02_13_429885	333	5	paper	paper	NN
10_1101-2021_02_13_429885	333	6	can	can	MD
10_1101-2021_02_13_429885	333	7	be	be	VB
10_1101-2021_02_13_429885	333	8	replicated	replicate	VBN
10_1101-2021_02_13_429885	333	9	following	follow	VBG
10_1101-2021_02_13_429885	333	10	the	the	DT
10_1101-2021_02_13_429885	333	11	vignettes	vignette	NNS
10_1101-2021_02_13_429885	333	12	.	.	.
10_1101-2021_02_13_429885	334	1	Authors	author	NNS
10_1101-2021_02_13_429885	334	2	contribution	contribution	NN
10_1101-2021_02_13_429885	334	3	.CC	.CC	,
10_1101-2021_02_13_429885	334	4	-	-	:
10_1101-2021_02_13_429885	334	5	BY	by	IN
10_1101-2021_02_13_429885	334	6	-	-	HYPH
10_1101-2021_02_13_429885	334	7	NC	NC	NNP
10_1101-2021_02_13_429885	334	8	-	-	HYPH
10_1101-2021_02_13_429885	334	9	ND	ND	NNP
10_1101-2021_02_13_429885	334	10	4.0	4.0	CD
10_1101-2021_02_13_429885	334	11	International	International	NNP
10_1101-2021_02_13_429885	334	12	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	334	13	under	under	IN
10_1101-2021_02_13_429885	334	14	a	a	DT
10_1101-2021_02_13_429885	334	15	(	(	-LRB-
10_1101-2021_02_13_429885	334	16	which	which	WDT
10_1101-2021_02_13_429885	334	17	was	be	VBD
10_1101-2021_02_13_429885	334	18	not	not	RB
10_1101-2021_02_13_429885	334	19	certified	certify	VBN
10_1101-2021_02_13_429885	334	20	by	by	IN
10_1101-2021_02_13_429885	334	21	peer	peer	NN
10_1101-2021_02_13_429885	334	22	review	review	NN
10_1101-2021_02_13_429885	334	23	)	)	-RRB-
10_1101-2021_02_13_429885	334	24	is	be	VBZ
10_1101-2021_02_13_429885	334	25	the	the	DT
10_1101-2021_02_13_429885	334	26	author	author	NN
10_1101-2021_02_13_429885	334	27	/	/	SYM
10_1101-2021_02_13_429885	334	28	funder	funder	NN
10_1101-2021_02_13_429885	334	29	,	,	,
10_1101-2021_02_13_429885	334	30	who	who	WP
10_1101-2021_02_13_429885	334	31	has	have	VBZ
10_1101-2021_02_13_429885	334	32	granted	grant	VBN
10_1101-2021_02_13_429885	334	33	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	334	34	a	a	DT
10_1101-2021_02_13_429885	334	35	license	license	NN
10_1101-2021_02_13_429885	334	36	to	to	TO
10_1101-2021_02_13_429885	334	37	display	display	VB
10_1101-2021_02_13_429885	334	38	the	the	DT
10_1101-2021_02_13_429885	334	39	preprint	preprint	NN
10_1101-2021_02_13_429885	334	40	in	in	IN
10_1101-2021_02_13_429885	334	41	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	334	42	.	.	.
10_1101-2021_02_13_429885	335	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	335	2	is	be	VBZ
10_1101-2021_02_13_429885	335	3	made	make	VBN
10_1101-2021_02_13_429885	335	4	The	the	DT
10_1101-2021_02_13_429885	335	5	copyright	copyright	NN
10_1101-2021_02_13_429885	335	6	holder	holder	NN
10_1101-2021_02_13_429885	335	7	for	for	IN
10_1101-2021_02_13_429885	335	8	this	this	DT
10_1101-2021_02_13_429885	335	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	335	10	version	version	NN
10_1101-2021_02_13_429885	335	11	posted	post	VBD
10_1101-2021_02_13_429885	335	12	February	February	NNP
10_1101-2021_02_13_429885	335	13	13	13	CD
10_1101-2021_02_13_429885	335	14	,	,	,
10_1101-2021_02_13_429885	335	15	2021	2021	CD
10_1101-2021_02_13_429885	335	16	.	.	.
10_1101-2021_02_13_429885	335	17	;	;	:
10_1101-2021_02_13_429885	335	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	335	19	:	:	:
10_1101-2021_02_13_429885	335	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	335	21	preprint	preprint	NNP
10_1101-2021_02_13_429885	335	22	http://paperpile.com/b/rqVmzs/67up	http://paperpile.com/b/rqVmzs/67up	NNP
10_1101-2021_02_13_429885	335	23	http://paperpile.com/b/rqVmzs/67up	http://paperpile.com/b/rqVmzs/67up	NNP
10_1101-2021_02_13_429885	335	24	http://paperpile.com/b/rqVmzs/67up	http://paperpile.com/b/rqVmzs/67up	NNP
10_1101-2021_02_13_429885	335	25	http://paperpile.com/b/rqVmzs/67up	http://paperpile.com/b/rqVmzs/67up	NNP
10_1101-2021_02_13_429885	335	26	http://paperpile.com/b/rqVmzs/67up	http://paperpile.com/b/rqVmzs/67up	NNP
10_1101-2021_02_13_429885	335	27	http://paperpile.com/b/rqVmzs/67up	http://paperpile.com/b/rqVmzs/67up	NNP
10_1101-2021_02_13_429885	335	28	http://dx.doi.org/10.1038/s41586-019-1689-y	http://dx.doi.org/10.1038/s41586-019-1689-y	NNP
10_1101-2021_02_13_429885	335	29	http://paperpile.com/b/rqVmzs/67up	http://paperpile.com/b/rqVmzs/67up	NNP
10_1101-2021_02_13_429885	335	30	http://paperpile.com/b/rqVmzs/JI4a	http://paperpile.com/b/rqVmzs/JI4a	NNP
10_1101-2021_02_13_429885	335	31	http://paperpile.com/b/rqVmzs/JI4a	http://paperpile.com/b/rqVmzs/JI4a	NNP
10_1101-2021_02_13_429885	335	32	http://paperpile.com/b/rqVmzs/JI4a	http://paperpile.com/b/rqVmzs/JI4a	NNP
10_1101-2021_02_13_429885	335	33	http://paperpile.com/b/rqVmzs/JI4a	http://paperpile.com/b/rqVmzs/JI4a	NNP
10_1101-2021_02_13_429885	335	34	http://paperpile.com/b/rqVmzs/JI4a	http://paperpile.com/b/rqVmzs/JI4a	NNP
10_1101-2021_02_13_429885	335	35	http://paperpile.com/b/rqVmzs/JI4a	http://paperpile.com/b/rqVmzs/JI4a	NNP
10_1101-2021_02_13_429885	335	36	http://dx.doi.org/10.1016/j.cell.2018.03.043	http://dx.doi.org/10.1016/j.cell.2018.03.043	NNP
10_1101-2021_02_13_429885	335	37	http://paperpile.com/b/rqVmzs/JI4a	http://paperpile.com/b/rqVmzs/JI4a	NNP
10_1101-2021_02_13_429885	335	38	http://paperpile.com/b/rqVmzs/mWfz	http://paperpile.com/b/rqVmzs/mWfz	NNP
10_1101-2021_02_13_429885	335	39	http://paperpile.com/b/rqVmzs/mWfz	http://paperpile.com/b/rqvmzs/mwfz	UH
10_1101-2021_02_13_429885	335	40	http://paperpile.com/b/rqVmzs/mWfz	http://paperpile.com/b/rqvmzs/mwfz	UH
10_1101-2021_02_13_429885	335	41	http://paperpile.com/b/rqVmzs/mWfz	http://paperpile.com/b/rqvmzs/mwfz	UH
10_1101-2021_02_13_429885	335	42	http://paperpile.com/b/rqVmzs/mWfz	http://paperpile.com/b/rqvmzs/mwfz	UH
10_1101-2021_02_13_429885	335	43	http://paperpile.com/b/rqVmzs/mWfz	http://paperpile.com/b/rqvmzs/mwfz	UH
10_1101-2021_02_13_429885	335	44	http://dx.doi.org/10.1136/bmj.k1687	http://dx.doi.org/10.1136/bmj.k1687	PRP$
10_1101-2021_02_13_429885	335	45	http://paperpile.com/b/rqVmzs/mWfz	http://paperpile.com/b/rqvmzs/mwfz	NN
10_1101-2021_02_13_429885	335	46	http://paperpile.com/b/rqVmzs/yAgN	http://paperpile.com/b/rqVmzs/yAgN	NNP
10_1101-2021_02_13_429885	335	47	http://paperpile.com/b/rqVmzs/yAgN	http://paperpile.com/b/rqVmzs/yAgN	NNP
10_1101-2021_02_13_429885	335	48	http://paperpile.com/b/rqVmzs/yAgN	http://paperpile.com/b/rqVmzs/yAgN	NNP
10_1101-2021_02_13_429885	335	49	http://paperpile.com/b/rqVmzs/yAgN	http://paperpile.com/b/rqVmzs/yAgN	NNP
10_1101-2021_02_13_429885	335	50	http://paperpile.com/b/rqVmzs/yAgN	http://paperpile.com/b/rqVmzs/yAgN	NNP
10_1101-2021_02_13_429885	335	51	http://dx.doi.org/10.1073/pnas.1009843107	http://dx.doi.org/10.1073/pnas.1009843107	NNP
10_1101-2021_02_13_429885	335	52	http://paperpile.com/b/rqVmzs/yAgN	http://paperpile.com/b/rqVmzs/yAgN	NNP
10_1101-2021_02_13_429885	335	53	http://paperpile.com/b/rqVmzs/NCPJ	http://paperpile.com/b/rqvmzs/ncpj	ADD
10_1101-2021_02_13_429885	335	54	http://paperpile.com/b/rqVmzs/NCPJ	http://paperpile.com/b/rqvmzs/ncpj	ADD
10_1101-2021_02_13_429885	335	55	http://paperpile.com/b/rqVmzs/NCPJ	http://paperpile.com/b/rqvmzs/ncpj	ADD
10_1101-2021_02_13_429885	335	56	http://paperpile.com/b/rqVmzs/NCPJ	http://paperpile.com/b/rqvmzs/ncpj	ADD
10_1101-2021_02_13_429885	335	57	http://paperpile.com/b/rqVmzs/NCPJ	http://paperpile.com/b/rqvmzs/ncpj	ADD
10_1101-2021_02_13_429885	335	58	http://paperpile.com/b/rqVmzs/NCPJ	http://paperpile.com/b/rqvmzs/ncpj	ADD
10_1101-2021_02_13_429885	335	59	http://dx.doi.org/10.1038/s41586-020-2698-6	http://dx.doi.org/10.1038/s41586-020-2698-6	NNP
10_1101-2021_02_13_429885	335	60	http://paperpile.com/b/rqVmzs/NCPJ	http://paperpile.com/b/rqvmzs/ncpj	ADD
10_1101-2021_02_13_429885	335	61	http://paperpile.com/b/rqVmzs/rmmC	http://paperpile.com/b/rqVmzs/rmmC	NNP
10_1101-2021_02_13_429885	335	62	http://paperpile.com/b/rqVmzs/rmmC	http://paperpile.com/b/rqVmzs/rmmC	NNP
10_1101-2021_02_13_429885	335	63	http://paperpile.com/b/rqVmzs/rmmC	http://paperpile.com/b/rqVmzs/rmmC	NNP
10_1101-2021_02_13_429885	335	64	http://paperpile.com/b/rqVmzs/rmmC	http://paperpile.com/b/rqVmzs/rmmC	NNP
10_1101-2021_02_13_429885	335	65	http://dx.doi.org/10.1038/s41467-020-17967-y	http://dx.doi.org/10.1038/s41467-020-17967-y	NNP
10_1101-2021_02_13_429885	335	66	http://paperpile.com/b/rqVmzs/rmmC	http://paperpile.com/b/rqVmzs/rmmC	NNP
10_1101-2021_02_13_429885	335	67	https://dcc.icgc.org/	https://dcc.icgc.org/	VBZ
10_1101-2021_02_13_429885	335	68	https://caravagnalab.github.io/CNAqc/	https://caravagnalab.github.io/cnaqc/	ADD
10_1101-2021_02_13_429885	335	69	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	NNP
10_1101-2021_02_13_429885	335	70	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	335	71	Househam	Househam	NNP
10_1101-2021_02_13_429885	335	72	et	et	FW
10_1101-2021_02_13_429885	335	73	al	al	NNP
10_1101-2021_02_13_429885	335	74	.	.	.
10_1101-2021_02_13_429885	336	1	A	a	DT
10_1101-2021_02_13_429885	336	2	fully	fully	RB
10_1101-2021_02_13_429885	336	3	automated	automate	VBN
10_1101-2021_02_13_429885	336	4	approach	approach	NN
10_1101-2021_02_13_429885	336	5	for	for	IN
10_1101-2021_02_13_429885	336	6	quality	quality	NN
10_1101-2021_02_13_429885	336	7	control	control	NN
10_1101-2021_02_13_429885	336	8	of	of	IN
10_1101-2021_02_13_429885	336	9	cancer	cancer	NN
10_1101-2021_02_13_429885	336	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	336	11	in	in	IN
10_1101-2021_02_13_429885	336	12	the	the	DT
10_1101-2021_02_13_429885	336	13	era	era	NN
10_1101-2021_02_13_429885	336	14	of	of	IN
10_1101-2021_02_13_429885	336	15	high	high	JJ
10_1101-2021_02_13_429885	336	16	-	-	HYPH
10_1101-2021_02_13_429885	336	17	resolution	resolution	NN
10_1101-2021_02_13_429885	336	18	whole	whole	JJ
10_1101-2021_02_13_429885	336	19	genome	genome	JJ
10_1101-2021_02_13_429885	336	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	336	21	.	.	.
10_1101-2021_02_13_429885	337	1	All	all	DT
10_1101-2021_02_13_429885	337	2	authors	author	NNS
10_1101-2021_02_13_429885	337	3	conceived	conceive	VBD
10_1101-2021_02_13_429885	337	4	the	the	DT
10_1101-2021_02_13_429885	337	5	method	method	NN
10_1101-2021_02_13_429885	337	6	,	,	,
10_1101-2021_02_13_429885	337	7	which	which	WDT
10_1101-2021_02_13_429885	337	8	GC	GC	NNP
10_1101-2021_02_13_429885	337	9	formalised	formalise	VBD
10_1101-2021_02_13_429885	337	10	and	and	CC
10_1101-2021_02_13_429885	337	11	implemented	implement	VBD
10_1101-2021_02_13_429885	337	12	.	.	.
10_1101-2021_02_13_429885	338	1	All	all	DT
10_1101-2021_02_13_429885	338	2	authors	author	NNS
10_1101-2021_02_13_429885	338	3	analysed	analyse	VBD
10_1101-2021_02_13_429885	338	4	the	the	DT
10_1101-2021_02_13_429885	338	5	data	datum	NNS
10_1101-2021_02_13_429885	338	6	and	and	CC
10_1101-2021_02_13_429885	338	7	wrote	write	VBD
10_1101-2021_02_13_429885	338	8	the	the	DT
10_1101-2021_02_13_429885	338	9	manuscript	manuscript	NN
10_1101-2021_02_13_429885	338	10	.	.	.
10_1101-2021_02_13_429885	339	1	Competing	compete	VBG
10_1101-2021_02_13_429885	339	2	interests	interest	NNS
10_1101-2021_02_13_429885	339	3	.	.	.
10_1101-2021_02_13_429885	340	1	The	the	DT
10_1101-2021_02_13_429885	340	2	authors	author	NNS
10_1101-2021_02_13_429885	340	3	declare	declare	VBP
10_1101-2021_02_13_429885	340	4	no	no	DT
10_1101-2021_02_13_429885	340	5	competing	compete	VBG
10_1101-2021_02_13_429885	340	6	interests	interest	NNS
10_1101-2021_02_13_429885	340	7	.	.	.
10_1101-2021_02_13_429885	341	1	Online	online	JJ
10_1101-2021_02_13_429885	341	2	methods	method	NNS
10_1101-2021_02_13_429885	341	3	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	341	4	supports	support	VBZ
10_1101-2021_02_13_429885	341	5	two	two	CD
10_1101-2021_02_13_429885	341	6	human	human	JJ
10_1101-2021_02_13_429885	341	7	genome	genome	JJ
10_1101-2021_02_13_429885	341	8	references	reference	NNS
10_1101-2021_02_13_429885	341	9	(	(	-LRB-
10_1101-2021_02_13_429885	341	10	GRCh38	GRCh38	NNP
10_1101-2021_02_13_429885	341	11	and	and	CC
10_1101-2021_02_13_429885	341	12	hg19	hg19	NNP
10_1101-2021_02_13_429885	341	13	)	)	-RRB-
10_1101-2021_02_13_429885	341	14	,	,	,
10_1101-2021_02_13_429885	341	15	and	and	CC
10_1101-2021_02_13_429885	341	16	the	the	DT
10_1101-2021_02_13_429885	341	17	most	most	RBS
10_1101-2021_02_13_429885	341	18	common	common	JJ
10_1101-2021_02_13_429885	341	19	CNA	CNA	NNP
10_1101-2021_02_13_429885	341	20	profiles	profile	NNS
10_1101-2021_02_13_429885	341	21	found	find	VBN
10_1101-2021_02_13_429885	341	22	in	in	IN
10_1101-2021_02_13_429885	341	23	cancers	cancer	NNS
10_1101-2021_02_13_429885	341	24	:	:	:
10_1101-2021_02_13_429885	341	25	●	●	.
10_1101-2021_02_13_429885	341	26	heterozygous	heterozygous	JJ
10_1101-2021_02_13_429885	341	27	diploid	diploid	NNP
10_1101-2021_02_13_429885	341	28	states	state	NNS
10_1101-2021_02_13_429885	341	29	(	(	-LRB-
10_1101-2021_02_13_429885	341	30	1:1	1:1	CD
10_1101-2021_02_13_429885	341	31	)	)	-RRB-
10_1101-2021_02_13_429885	341	32	;	;	:
10_1101-2021_02_13_429885	341	33	2	2	LS
10_1101-2021_02_13_429885	341	34	●	●	:
10_1101-2021_02_13_429885	341	35	loss	loss	NN
10_1101-2021_02_13_429885	341	36	of	of	IN
10_1101-2021_02_13_429885	341	37	heterozygosity	heterozygosity	NN
10_1101-2021_02_13_429885	341	38	(	(	-LRB-
10_1101-2021_02_13_429885	341	39	LOH	LOH	NNP
10_1101-2021_02_13_429885	341	40	)	)	-RRB-
10_1101-2021_02_13_429885	341	41	in	in	IN
10_1101-2021_02_13_429885	341	42	monosomy	monosomy	NNP
10_1101-2021_02_13_429885	341	43	(	(	-LRB-
10_1101-2021_02_13_429885	341	44	1:0	1:0	CD
10_1101-2021_02_13_429885	341	45	)	)	-RRB-
10_1101-2021_02_13_429885	341	46	and	and	CC
10_1101-2021_02_13_429885	341	47	copy	copy	NN
10_1101-2021_02_13_429885	341	48	-	-	HYPH
10_1101-2021_02_13_429885	341	49	neutral	neutral	JJ
10_1101-2021_02_13_429885	341	50	(	(	-LRB-
10_1101-2021_02_13_429885	341	51	2:0	2:0	CD
10_1101-2021_02_13_429885	341	52	)	)	-RRB-
10_1101-2021_02_13_429885	341	53	states	state	NNS
10_1101-2021_02_13_429885	341	54	;	;	:
10_1101-2021_02_13_429885	341	55	●	●	NFP
10_1101-2021_02_13_429885	341	56	triploid	triploid	NNP
10_1101-2021_02_13_429885	341	57	(	(	-LRB-
10_1101-2021_02_13_429885	341	58	AAB	AAB	NNP
10_1101-2021_02_13_429885	341	59	or	or	CC
10_1101-2021_02_13_429885	341	60	2:1	2:1	CD
10_1101-2021_02_13_429885	341	61	)	)	-RRB-
10_1101-2021_02_13_429885	341	62	or	or	CC
10_1101-2021_02_13_429885	341	63	tetraploid	tetraploid	NN
10_1101-2021_02_13_429885	341	64	(	(	-LRB-
10_1101-2021_02_13_429885	341	65	AABB	AABB	NNP
10_1101-2021_02_13_429885	341	66	or	or	CC
10_1101-2021_02_13_429885	341	67	2:2	2:2	CD
10_1101-2021_02_13_429885	341	68	)	)	-RRB-
10_1101-2021_02_13_429885	341	69	states	state	NNS
10_1101-2021_02_13_429885	341	70	.	.	.
10_1101-2021_02_13_429885	342	1	We	-PRON-	PRP
10_1101-2021_02_13_429885	342	2	make	make	VBP
10_1101-2021_02_13_429885	342	3	a	a	DT
10_1101-2021_02_13_429885	342	4	simplifying	simplify	VBG
10_1101-2021_02_13_429885	342	5	assumption	assumption	NN
10_1101-2021_02_13_429885	342	6	,	,	,
10_1101-2021_02_13_429885	342	7	whereby	whereby	WRB
10_1101-2021_02_13_429885	342	8	CNAs	cna	NNS
10_1101-2021_02_13_429885	342	9	have	have	VBP
10_1101-2021_02_13_429885	342	10	been	be	VBN
10_1101-2021_02_13_429885	342	11	acquired	acquire	VBN
10_1101-2021_02_13_429885	342	12	in	in	IN
10_1101-2021_02_13_429885	342	13	one	one	CD
10_1101-2021_02_13_429885	342	14	step	step	NN
10_1101-2021_02_13_429885	342	15	,	,	,
10_1101-2021_02_13_429885	342	16	starting	start	VBG
10_1101-2021_02_13_429885	342	17	from	from	IN
10_1101-2021_02_13_429885	342	18	a	a	DT
10_1101-2021_02_13_429885	342	19	simple	simple	JJ
10_1101-2021_02_13_429885	342	20	heterozygous	heterozygous	JJ
10_1101-2021_02_13_429885	342	21	diploid	diploid	NN
10_1101-2021_02_13_429885	342	22	state	state	NN
10_1101-2021_02_13_429885	342	23	(	(	-LRB-
10_1101-2021_02_13_429885	342	24	the	the	DT
10_1101-2021_02_13_429885	342	25	germline	germline	NN
10_1101-2021_02_13_429885	342	26	)	)	-RRB-
10_1101-2021_02_13_429885	342	27	.	.	.
10_1101-2021_02_13_429885	343	1	For	for	IN
10_1101-2021_02_13_429885	343	2	this	this	DT
10_1101-2021_02_13_429885	343	3	reason	reason	NN
10_1101-2021_02_13_429885	343	4	,	,	,
10_1101-2021_02_13_429885	343	5	for	for	IN
10_1101-2021_02_13_429885	343	6	tetraploid	tetraploid	NN
10_1101-2021_02_13_429885	343	7	segments	segment	NNS
10_1101-2021_02_13_429885	343	8	we	-PRON-	PRP
10_1101-2021_02_13_429885	343	9	only	only	RB
10_1101-2021_02_13_429885	343	10	consider	consider	VBP
10_1101-2021_02_13_429885	343	11	copy	copy	NN
10_1101-2021_02_13_429885	343	12	state	state	NN
10_1101-2021_02_13_429885	343	13	2:2	2:2	CD
10_1101-2021_02_13_429885	343	14	,	,	,
10_1101-2021_02_13_429885	343	15	instead	instead	RB
10_1101-2021_02_13_429885	343	16	of	of	IN
10_1101-2021_02_13_429885	343	17	3:1	3:1	CD
10_1101-2021_02_13_429885	343	18	or	or	CC
10_1101-2021_02_13_429885	343	19	4:0	4:0	CD
10_1101-2021_02_13_429885	343	20	.	.	.
10_1101-2021_02_13_429885	344	1	This	this	DT
10_1101-2021_02_13_429885	344	2	allows	allow	VBZ
10_1101-2021_02_13_429885	344	3	us	-PRON-	PRP
10_1101-2021_02_13_429885	344	4	to	to	TO
10_1101-2021_02_13_429885	344	5	make	make	VB
10_1101-2021_02_13_429885	344	6	simpler	simple	JJR
10_1101-2021_02_13_429885	344	7	computations	computation	NNS
10_1101-2021_02_13_429885	344	8	.	.	.
10_1101-2021_02_13_429885	345	1	In	in	IN
10_1101-2021_02_13_429885	345	2	practice	practice	NN
10_1101-2021_02_13_429885	345	3	,	,	,
10_1101-2021_02_13_429885	345	4	we	-PRON-	PRP
10_1101-2021_02_13_429885	345	5	avoid	avoid	VBP
10_1101-2021_02_13_429885	345	6	working	work	VBG
10_1101-2021_02_13_429885	345	7	with	with	IN
10_1101-2021_02_13_429885	345	8	copy	copy	NN
10_1101-2021_02_13_429885	345	9	states	state	NNS
10_1101-2021_02_13_429885	345	10	for	for	IN
10_1101-2021_02_13_429885	345	11	which	which	WDT
10_1101-2021_02_13_429885	345	12	the	the	DT
10_1101-2021_02_13_429885	345	13	computation	computation	NN
10_1101-2021_02_13_429885	345	14	of	of	IN
10_1101-2021_02_13_429885	345	15	CCFs	ccf	NNS
10_1101-2021_02_13_429885	345	16	is	be	VBZ
10_1101-2021_02_13_429885	345	17	very	very	RB
10_1101-2021_02_13_429885	345	18	difficult	difficult	JJ
10_1101-2021_02_13_429885	345	19	,	,	,
10_1101-2021_02_13_429885	345	20	and	and	CC
10_1101-2021_02_13_429885	345	21	that	that	WDT
10_1101-2021_02_13_429885	345	22	are	be	VBP
10_1101-2021_02_13_429885	345	23	quite	quite	RB
10_1101-2021_02_13_429885	345	24	unlikely	unlikely	JJ
10_1101-2021_02_13_429885	345	25	to	to	TO
10_1101-2021_02_13_429885	345	26	be	be	VB
10_1101-2021_02_13_429885	345	27	observed	observe	VBN
10_1101-2021_02_13_429885	345	28	in	in	IN
10_1101-2021_02_13_429885	345	29	real	real	JJ
10_1101-2021_02_13_429885	345	30	data	datum	NNS
10_1101-2021_02_13_429885	345	31	.	.	.
10_1101-2021_02_13_429885	346	1	Also	also	RB
10_1101-2021_02_13_429885	346	2	,	,	,
10_1101-2021_02_13_429885	346	3	we	-PRON-	PRP
10_1101-2021_02_13_429885	346	4	consider	consider	VBP
10_1101-2021_02_13_429885	346	5	only	only	RB
10_1101-2021_02_13_429885	346	6	clonal	clonal	JJ
10_1101-2021_02_13_429885	346	7	CNA	cna	NN
10_1101-2021_02_13_429885	346	8	segments	segment	NNS
10_1101-2021_02_13_429885	346	9	.	.	.
10_1101-2021_02_13_429885	347	1	While	while	IN
10_1101-2021_02_13_429885	347	2	subclonal	subclonal	JJ
10_1101-2021_02_13_429885	347	3	CNA	CNA	NNP
10_1101-2021_02_13_429885	347	4	segments	segment	NNS
10_1101-2021_02_13_429885	347	5	are	be	VBP
10_1101-2021_02_13_429885	347	6	certainly	certainly	RB
10_1101-2021_02_13_429885	347	7	important	important	JJ
10_1101-2021_02_13_429885	347	8	for	for	IN
10_1101-2021_02_13_429885	347	9	cancer	cancer	NN
10_1101-2021_02_13_429885	347	10	genomics	genomic	NNS
10_1101-2021_02_13_429885	347	11	,	,	,
10_1101-2021_02_13_429885	347	12	the	the	DT
10_1101-2021_02_13_429885	347	13	calls	call	NNS
10_1101-2021_02_13_429885	347	14	that	that	WDT
10_1101-2021_02_13_429885	347	15	we	-PRON-	PRP
10_1101-2021_02_13_429885	347	16	seek	seek	VBP
10_1101-2021_02_13_429885	347	17	to	to	TO
10_1101-2021_02_13_429885	347	18	quality	quality	NN
10_1101-2021_02_13_429885	347	19	check	check	NN
10_1101-2021_02_13_429885	347	20	regard	regard	NN
10_1101-2021_02_13_429885	347	21	just	just	RB
10_1101-2021_02_13_429885	347	22	clonal	clonal	JJ
10_1101-2021_02_13_429885	347	23	CNA	CNA	NNP
10_1101-2021_02_13_429885	347	24	events	event	NNS
10_1101-2021_02_13_429885	347	25	;	;	:
10_1101-2021_02_13_429885	347	26	being	be	VBG
10_1101-2021_02_13_429885	347	27	the	the	DT
10_1101-2021_02_13_429885	347	28	one	one	NN
10_1101-2021_02_13_429885	347	29	most	most	RBS
10_1101-2021_02_13_429885	347	30	prevalent	prevalent	JJ
10_1101-2021_02_13_429885	347	31	in	in	IN
10_1101-2021_02_13_429885	347	32	the	the	DT
10_1101-2021_02_13_429885	347	33	majority	majority	NN
10_1101-2021_02_13_429885	347	34	of	of	IN
10_1101-2021_02_13_429885	347	35	cancer	cancer	NN
10_1101-2021_02_13_429885	347	36	cells	cell	NNS
10_1101-2021_02_13_429885	347	37	,	,	,
10_1101-2021_02_13_429885	347	38	they	-PRON-	PRP
10_1101-2021_02_13_429885	347	39	have	have	VBP
10_1101-2021_02_13_429885	347	40	to	to	TO
10_1101-2021_02_13_429885	347	41	be	be	VB
10_1101-2021_02_13_429885	347	42	prioritised	prioritise	VBN
10_1101-2021_02_13_429885	347	43	,	,	,
10_1101-2021_02_13_429885	347	44	with	with	IN
10_1101-2021_02_13_429885	347	45	subclonal	subclonal	JJ
10_1101-2021_02_13_429885	347	46	CNAs	cna	NNS
10_1101-2021_02_13_429885	347	47	being	be	VBG
10_1101-2021_02_13_429885	347	48	only	only	RB
10_1101-2021_02_13_429885	347	49	reliable	reliable	JJ
10_1101-2021_02_13_429885	347	50	for	for	IN
10_1101-2021_02_13_429885	347	51	tumours	tumour	NNS
10_1101-2021_02_13_429885	347	52	with	with	IN
10_1101-2021_02_13_429885	347	53	good	good	JJ
10_1101-2021_02_13_429885	347	54	clonal	clonal	JJ
10_1101-2021_02_13_429885	347	55	CNA	CNA	NNP
10_1101-2021_02_13_429885	347	56	calls	call	NNS
10_1101-2021_02_13_429885	347	57	.	.	.
10_1101-2021_02_13_429885	348	1	CNAqc	cnaqc	NN
10_1101-2021_02_13_429885	348	2	works	work	VBZ
10_1101-2021_02_13_429885	348	3	primarily	primarily	RB
10_1101-2021_02_13_429885	348	4	with	with	IN
10_1101-2021_02_13_429885	348	5	Whole	whole	JJ
10_1101-2021_02_13_429885	348	6	-	-	HYPH
10_1101-2021_02_13_429885	348	7	Genome	genome	NN
10_1101-2021_02_13_429885	348	8	Sequencing	sequencing	NN
10_1101-2021_02_13_429885	348	9	(	(	-LRB-
10_1101-2021_02_13_429885	348	10	WGS	WGS	NNP
10_1101-2021_02_13_429885	348	11	)	)	-RRB-
10_1101-2021_02_13_429885	348	12	data	datum	NNS
10_1101-2021_02_13_429885	348	13	.	.	.
10_1101-2021_02_13_429885	349	1	For	for	IN
10_1101-2021_02_13_429885	349	2	exome	exome	JJ
10_1101-2021_02_13_429885	349	3	data	datum	NNS
10_1101-2021_02_13_429885	349	4	,	,	,
10_1101-2021_02_13_429885	349	5	the	the	DT
10_1101-2021_02_13_429885	349	6	reduced	reduce	VBN
10_1101-2021_02_13_429885	349	7	exonic	exonic	JJ
10_1101-2021_02_13_429885	349	8	mutation	mutation	NN
10_1101-2021_02_13_429885	349	9	burden	burden	NN
10_1101-2021_02_13_429885	349	10	can	can	MD
10_1101-2021_02_13_429885	349	11	make	make	VB
10_1101-2021_02_13_429885	349	12	it	-PRON-	PRP
10_1101-2021_02_13_429885	349	13	more	more	RBR
10_1101-2021_02_13_429885	349	14	difficult	difficult	JJ
10_1101-2021_02_13_429885	349	15	to	to	TO
10_1101-2021_02_13_429885	349	16	work	work	VB
10_1101-2021_02_13_429885	349	17	with	with	IN
10_1101-2021_02_13_429885	349	18	the	the	DT
10_1101-2021_02_13_429885	349	19	spectrum	spectrum	NN
10_1101-2021_02_13_429885	349	20	of	of	IN
10_1101-2021_02_13_429885	349	21	the	the	DT
10_1101-2021_02_13_429885	349	22	VAF	VAF	NNP
10_1101-2021_02_13_429885	349	23	distribution	distribution	NN
10_1101-2021_02_13_429885	349	24	.	.	.
10_1101-2021_02_13_429885	350	1	In	in	IN
10_1101-2021_02_13_429885	350	2	general	general	JJ
10_1101-2021_02_13_429885	350	3	,	,	,
10_1101-2021_02_13_429885	350	4	the	the	DT
10_1101-2021_02_13_429885	350	5	key	key	JJ
10_1101-2021_02_13_429885	350	6	determinant	determinant	NN
10_1101-2021_02_13_429885	350	7	to	to	TO
10_1101-2021_02_13_429885	350	8	detect	detect	VB
10_1101-2021_02_13_429885	350	9	peaks	peak	NNS
10_1101-2021_02_13_429885	350	10	in	in	IN
10_1101-2021_02_13_429885	350	11	the	the	DT
10_1101-2021_02_13_429885	350	12	VAF	VAF	NNP
10_1101-2021_02_13_429885	350	13	,	,	,
10_1101-2021_02_13_429885	350	14	is	be	VBZ
10_1101-2021_02_13_429885	350	15	the	the	DT
10_1101-2021_02_13_429885	350	16	number	number	NN
10_1101-2021_02_13_429885	350	17	of	of	IN
10_1101-2021_02_13_429885	350	18	mutations	mutation	NNS
10_1101-2021_02_13_429885	350	19	per	per	IN
10_1101-2021_02_13_429885	350	20	copy	copy	NN
10_1101-2021_02_13_429885	350	21	state	state	NN
10_1101-2021_02_13_429885	350	22	.	.	.
10_1101-2021_02_13_429885	351	1	For	for	IN
10_1101-2021_02_13_429885	351	2	tumours	tumour	NNS
10_1101-2021_02_13_429885	351	3	with	with	IN
10_1101-2021_02_13_429885	351	4	strong	strong	JJ
10_1101-2021_02_13_429885	351	5	endogenous	endogenous	JJ
10_1101-2021_02_13_429885	351	6	mutant	mutant	NN
10_1101-2021_02_13_429885	351	7	factors	factor	NNS
10_1101-2021_02_13_429885	351	8	(	(	-LRB-
10_1101-2021_02_13_429885	351	9	e.g.	e.g.	RB
10_1101-2021_02_13_429885	351	10	,	,	,
10_1101-2021_02_13_429885	351	11	smoking	smoke	VBG
10_1101-2021_02_13_429885	351	12	)	)	-RRB-
10_1101-2021_02_13_429885	351	13	or	or	CC
10_1101-2021_02_13_429885	351	14	very	very	RB
10_1101-2021_02_13_429885	351	15	high	high	JJ
10_1101-2021_02_13_429885	351	16	mutation	mutation	NN
10_1101-2021_02_13_429885	351	17	rate	rate	NN
10_1101-2021_02_13_429885	351	18	(	(	-LRB-
10_1101-2021_02_13_429885	351	19	e.g.	e.g.	RB
10_1101-2021_02_13_429885	351	20	,	,	,
10_1101-2021_02_13_429885	351	21	microsatellite	microsatellite	NNP
10_1101-2021_02_13_429885	351	22	unstable	unstable	JJ
10_1101-2021_02_13_429885	351	23	tumours	tumour	NNS
10_1101-2021_02_13_429885	351	24	)	)	-RRB-
10_1101-2021_02_13_429885	351	25	,	,	,
10_1101-2021_02_13_429885	351	26	the	the	DT
10_1101-2021_02_13_429885	351	27	number	number	NN
10_1101-2021_02_13_429885	351	28	of	of	IN
10_1101-2021_02_13_429885	351	29	exonic	exonic	JJ
10_1101-2021_02_13_429885	351	30	mutations	mutation	NNS
10_1101-2021_02_13_429885	351	31	could	could	MD
10_1101-2021_02_13_429885	351	32	be	be	VB
10_1101-2021_02_13_429885	351	33	high	high	JJ
10_1101-2021_02_13_429885	351	34	enough	enough	RB
10_1101-2021_02_13_429885	351	35	to	to	TO
10_1101-2021_02_13_429885	351	36	use	use	VB
10_1101-2021_02_13_429885	351	37	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	351	38	.	.	.
10_1101-2021_02_13_429885	352	1	Peak	peak	NN
10_1101-2021_02_13_429885	352	2	-	-	HYPH
10_1101-2021_02_13_429885	352	3	detection	detection	NN
10_1101-2021_02_13_429885	352	4	QC	qc	NN
10_1101-2021_02_13_429885	352	5	2	2	CD
10_1101-2021_02_13_429885	352	6	The	the	DT
10_1101-2021_02_13_429885	352	7	notation	notation	NN
10_1101-2021_02_13_429885	352	8	1:1	1:1	CD
10_1101-2021_02_13_429885	352	9	is	be	VBZ
10_1101-2021_02_13_429885	352	10	sometimes	sometimes	RB
10_1101-2021_02_13_429885	352	11	analogously	analogously	RB
10_1101-2021_02_13_429885	352	12	expressed	express	VBN
10_1101-2021_02_13_429885	352	13	as	as	IN
10_1101-2021_02_13_429885	352	14	genotype	genotype	NN
10_1101-2021_02_13_429885	352	15	AB	AB	NNP
10_1101-2021_02_13_429885	352	16	,	,	,
10_1101-2021_02_13_429885	352	17	1:0	1:0	CD
10_1101-2021_02_13_429885	352	18	as	as	IN
10_1101-2021_02_13_429885	352	19	A	a	NN
10_1101-2021_02_13_429885	352	20	,	,	,
10_1101-2021_02_13_429885	352	21	2:1	2:1	CD
10_1101-2021_02_13_429885	352	22	as	as	IN
10_1101-2021_02_13_429885	352	23	AAB	AAB	NNP
10_1101-2021_02_13_429885	352	24	and	and	CC
10_1101-2021_02_13_429885	352	25	2:2	2:2	CD
10_1101-2021_02_13_429885	352	26	as	as	IN
10_1101-2021_02_13_429885	352	27	AABB	AABB	NNP
10_1101-2021_02_13_429885	352	28	.	.	.
10_1101-2021_02_13_429885	353	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	353	2	-	-	:
10_1101-2021_02_13_429885	353	3	BY	by	IN
10_1101-2021_02_13_429885	353	4	-	-	HYPH
10_1101-2021_02_13_429885	353	5	NC	NC	NNP
10_1101-2021_02_13_429885	353	6	-	-	HYPH
10_1101-2021_02_13_429885	353	7	ND	ND	NNP
10_1101-2021_02_13_429885	353	8	4.0	4.0	CD
10_1101-2021_02_13_429885	353	9	International	International	NNP
10_1101-2021_02_13_429885	353	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	353	11	under	under	IN
10_1101-2021_02_13_429885	353	12	a	a	DT
10_1101-2021_02_13_429885	353	13	(	(	-LRB-
10_1101-2021_02_13_429885	353	14	which	which	WDT
10_1101-2021_02_13_429885	353	15	was	be	VBD
10_1101-2021_02_13_429885	353	16	not	not	RB
10_1101-2021_02_13_429885	353	17	certified	certify	VBN
10_1101-2021_02_13_429885	353	18	by	by	IN
10_1101-2021_02_13_429885	353	19	peer	peer	NN
10_1101-2021_02_13_429885	353	20	review	review	NN
10_1101-2021_02_13_429885	353	21	)	)	-RRB-
10_1101-2021_02_13_429885	353	22	is	be	VBZ
10_1101-2021_02_13_429885	353	23	the	the	DT
10_1101-2021_02_13_429885	353	24	author	author	NN
10_1101-2021_02_13_429885	353	25	/	/	SYM
10_1101-2021_02_13_429885	353	26	funder	funder	NN
10_1101-2021_02_13_429885	353	27	,	,	,
10_1101-2021_02_13_429885	353	28	who	who	WP
10_1101-2021_02_13_429885	353	29	has	have	VBZ
10_1101-2021_02_13_429885	353	30	granted	grant	VBN
10_1101-2021_02_13_429885	353	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	353	32	a	a	DT
10_1101-2021_02_13_429885	353	33	license	license	NN
10_1101-2021_02_13_429885	353	34	to	to	TO
10_1101-2021_02_13_429885	353	35	display	display	VB
10_1101-2021_02_13_429885	353	36	the	the	DT
10_1101-2021_02_13_429885	353	37	preprint	preprint	NN
10_1101-2021_02_13_429885	353	38	in	in	IN
10_1101-2021_02_13_429885	353	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	353	40	.	.	.
10_1101-2021_02_13_429885	354	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	354	2	is	be	VBZ
10_1101-2021_02_13_429885	354	3	made	make	VBN
10_1101-2021_02_13_429885	354	4	The	the	DT
10_1101-2021_02_13_429885	354	5	copyright	copyright	NN
10_1101-2021_02_13_429885	354	6	holder	holder	NN
10_1101-2021_02_13_429885	354	7	for	for	IN
10_1101-2021_02_13_429885	354	8	this	this	DT
10_1101-2021_02_13_429885	354	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	354	10	version	version	NN
10_1101-2021_02_13_429885	354	11	posted	post	VBD
10_1101-2021_02_13_429885	354	12	February	February	NNP
10_1101-2021_02_13_429885	354	13	13	13	CD
10_1101-2021_02_13_429885	354	14	,	,	,
10_1101-2021_02_13_429885	354	15	2021	2021	CD
10_1101-2021_02_13_429885	354	16	.	.	.
10_1101-2021_02_13_429885	354	17	;	;	:
10_1101-2021_02_13_429885	354	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	354	19	:	:	:
10_1101-2021_02_13_429885	354	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	354	21	preprint	preprint	NN
10_1101-2021_02_13_429885	354	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	354	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	354	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	354	25	et	et	FW
10_1101-2021_02_13_429885	354	26	al	al	NNP
10_1101-2021_02_13_429885	354	27	.	.	.
10_1101-2021_02_13_429885	355	1	A	a	DT
10_1101-2021_02_13_429885	355	2	fully	fully	RB
10_1101-2021_02_13_429885	355	3	automated	automate	VBN
10_1101-2021_02_13_429885	355	4	approach	approach	NN
10_1101-2021_02_13_429885	355	5	for	for	IN
10_1101-2021_02_13_429885	355	6	quality	quality	NN
10_1101-2021_02_13_429885	355	7	control	control	NN
10_1101-2021_02_13_429885	355	8	of	of	IN
10_1101-2021_02_13_429885	355	9	cancer	cancer	NN
10_1101-2021_02_13_429885	355	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	355	11	in	in	IN
10_1101-2021_02_13_429885	355	12	the	the	DT
10_1101-2021_02_13_429885	355	13	era	era	NN
10_1101-2021_02_13_429885	355	14	of	of	IN
10_1101-2021_02_13_429885	355	15	high	high	JJ
10_1101-2021_02_13_429885	355	16	-	-	HYPH
10_1101-2021_02_13_429885	355	17	resolution	resolution	NN
10_1101-2021_02_13_429885	355	18	whole	whole	JJ
10_1101-2021_02_13_429885	355	19	genome	genome	JJ
10_1101-2021_02_13_429885	355	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	355	21	.	.	.
10_1101-2021_02_13_429885	356	1	We	-PRON-	PRP
10_1101-2021_02_13_429885	356	2	consider	consider	VBP
10_1101-2021_02_13_429885	356	3	a	a	DT
10_1101-2021_02_13_429885	356	4	somatic	somatic	JJ
10_1101-2021_02_13_429885	356	5	mutation	mutation	NN
10_1101-2021_02_13_429885	356	6	​present	​present	CD
10_1101-2021_02_13_429885	356	7	in	in	IN
10_1101-2021_02_13_429885	356	8	𝑚	𝑚	DT
10_1101-2021_02_13_429885	356	9	copies	copy	NNS
10_1101-2021_02_13_429885	356	10	of	of	IN
10_1101-2021_02_13_429885	356	11	the	the	DT
10_1101-2021_02_13_429885	356	12	tumour	tumour	NN
10_1101-2021_02_13_429885	356	13	genome	genome	NN
10_1101-2021_02_13_429885	356	14	,	,	,
10_1101-2021_02_13_429885	356	15	when	when	WRB
10_1101-2021_02_13_429885	356	16	the	the	DT
10_1101-2021_02_13_429885	356	17	sample	sample	NN
10_1101-2021_02_13_429885	356	18	purity	purity	NN
10_1101-2021_02_13_429885	356	19	is	be	VBZ
10_1101-2021_02_13_429885	356	20	𝜋	𝜋	NN
10_1101-2021_02_13_429885	356	21	and	and	CC
10_1101-2021_02_13_429885	356	22	the	the	DT
10_1101-2021_02_13_429885	356	23	segment	segment	NN
10_1101-2021_02_13_429885	356	24	ploidy	ploidy	NN
10_1101-2021_02_13_429885	356	25	is	be	VBZ
10_1101-2021_02_13_429885	356	26	𝑝.	𝑝.	NN
10_1101-2021_02_13_429885	357	1	Note	note	VB
10_1101-2021_02_13_429885	357	2	that	that	DT
10_1101-2021_02_13_429885	357	3	can	can	MD
10_1101-2021_02_13_429885	357	4	be	be	VB
10_1101-2021_02_13_429885	357	5	computed	compute	VBN
10_1101-2021_02_13_429885	357	6	summing	sum	VBG
10_1101-2021_02_13_429885	357	7	p	p	NN
10_1101-2021_02_13_429885	357	8	the	the	DT
10_1101-2021_02_13_429885	357	9	total	total	JJ
10_1101-2021_02_13_429885	357	10	number	number	NN
10_1101-2021_02_13_429885	357	11	of	of	IN
10_1101-2021_02_13_429885	357	12	copies	copy	NNS
10_1101-2021_02_13_429885	357	13	of	of	IN
10_1101-2021_02_13_429885	357	14	the	the	DT
10_1101-2021_02_13_429885	357	15	minor	minor	JJ
10_1101-2021_02_13_429885	357	16	and	and	CC
10_1101-2021_02_13_429885	357	17	major	major	JJ
10_1101-2021_02_13_429885	357	18	allele	allele	NNS
10_1101-2021_02_13_429885	357	19	at	at	IN
10_1101-2021_02_13_429885	357	20	the	the	DT
10_1101-2021_02_13_429885	357	21	mutation	mutation	NN
10_1101-2021_02_13_429885	357	22	locus	locus	NN
10_1101-2021_02_13_429885	357	23	(	(	-LRB-
10_1101-2021_02_13_429885	357	24	​Figure	​figure	NN
10_1101-2021_02_13_429885	357	25	1	1	CD
10_1101-2021_02_13_429885	357	26	​	​	UH
10_1101-2021_02_13_429885	357	27	)	)	-RRB-
10_1101-2021_02_13_429885	357	28	.	.	.
10_1101-2021_02_13_429885	358	1	The	the	DT
10_1101-2021_02_13_429885	358	2	key	key	JJ
10_1101-2021_02_13_429885	358	3	equations	equation	NNS
10_1101-2021_02_13_429885	358	4	for	for	IN
10_1101-2021_02_13_429885	358	5	the	the	DT
10_1101-2021_02_13_429885	358	6	expected	expect	VBN
10_1101-2021_02_13_429885	358	7	VAF	VAF	NNP
10_1101-2021_02_13_429885	358	8	of	of	IN
10_1101-2021_02_13_429885	358	9	a	a	DT
10_1101-2021_02_13_429885	358	10	clonal	clonal	JJ
10_1101-2021_02_13_429885	358	11	mutation	mutation	NN
10_1101-2021_02_13_429885	358	12	and	and	CC
10_1101-2021_02_13_429885	358	13	its	-PRON-	PRP$
10_1101-2021_02_13_429885	358	14	CCF	ccf	NN
10_1101-2021_02_13_429885	358	15	are	be	VBP
10_1101-2021_02_13_429885	358	16	presented	present	VBN
10_1101-2021_02_13_429885	358	17	in	in	IN
10_1101-2021_02_13_429885	358	18	the	the	DT
10_1101-2021_02_13_429885	358	19	Main	Main	NNP
10_1101-2021_02_13_429885	358	20	Text	Text	NNP
10_1101-2021_02_13_429885	358	21	.	.	.
10_1101-2021_02_13_429885	359	1	Here	here	RB
10_1101-2021_02_13_429885	359	2	we	-PRON-	PRP
10_1101-2021_02_13_429885	359	3	discuss	discuss	VBP
10_1101-2021_02_13_429885	359	4	how	how	WRB
10_1101-2021_02_13_429885	359	5	​peaks	​peak	NNS
10_1101-2021_02_13_429885	359	6	can	can	MD
10_1101-2021_02_13_429885	359	7	be	be	VB
10_1101-2021_02_13_429885	359	8	used	use	VBN
10_1101-2021_02_13_429885	359	9	to	to	IN
10_1101-2021_02_13_429885	359	10	QC	QC	NNP
10_1101-2021_02_13_429885	359	11	both	both	CC
10_1101-2021_02_13_429885	359	12	tumour	tumour	NN
10_1101-2021_02_13_429885	359	13	purity	purity	NN
10_1101-2021_02_13_429885	359	14	and	and	CC
10_1101-2021_02_13_429885	359	15	CNA	CNA	NNP
10_1101-2021_02_13_429885	359	16	segments	segment	NNS
10_1101-2021_02_13_429885	359	17	and	and	CC
10_1101-2021_02_13_429885	359	18	,	,	,
10_1101-2021_02_13_429885	359	19	consequently	consequently	RB
10_1101-2021_02_13_429885	359	20	,	,	,
10_1101-2021_02_13_429885	359	21	overall	overall	JJ
10_1101-2021_02_13_429885	359	22	tumour	tumour	NN
10_1101-2021_02_13_429885	359	23	ploidy	ploidy	NN
10_1101-2021_02_13_429885	359	24	.	.	.
10_1101-2021_02_13_429885	360	1	From	from	IN
10_1101-2021_02_13_429885	360	2	a	a	DT
10_1101-2021_02_13_429885	360	3	QC	QC	NNP
10_1101-2021_02_13_429885	360	4	perspective	perspective	NN
10_1101-2021_02_13_429885	360	5	,	,	,
10_1101-2021_02_13_429885	360	6	if	if	IN
10_1101-2021_02_13_429885	360	7	we	-PRON-	PRP
10_1101-2021_02_13_429885	360	8	solve	solve	VBP
10_1101-2021_02_13_429885	360	9	for	for	IN
10_1101-2021_02_13_429885	360	10	and	and	CC
10_1101-2021_02_13_429885	360	11	the	the	DT
10_1101-2021_02_13_429885	360	12	equations	equation	NNS
10_1101-2021_02_13_429885	360	13	,	,	,
10_1101-2021_02_13_429885	360	14	we	-PRON-	PRP
10_1101-2021_02_13_429885	360	15	can	can	MD
10_1101-2021_02_13_429885	360	16	get	get	VB
10_1101-2021_02_13_429885	360	17	as	as	IN
10_1101-2021_02_13_429885	360	18	which	which	WDT
10_1101-2021_02_13_429885	360	19	means	mean	VBZ
10_1101-2021_02_13_429885	360	20	that	that	IN
10_1101-2021_02_13_429885	360	21	if	if	IN
10_1101-2021_02_13_429885	360	22	we	-PRON-	PRP
10_1101-2021_02_13_429885	360	23	know	know	VBP
10_1101-2021_02_13_429885	360	24	tumour	tumour	NN
10_1101-2021_02_13_429885	360	25	purity	purity	NN
10_1101-2021_02_13_429885	360	26	and	and	CC
10_1101-2021_02_13_429885	360	27	CNA	CNA	NNP
10_1101-2021_02_13_429885	360	28	,	,	,
10_1101-2021_02_13_429885	360	29	we	-PRON-	PRP
10_1101-2021_02_13_429885	360	30	expect	expect	VBP
10_1101-2021_02_13_429885	360	31	a	a	DT
10_1101-2021_02_13_429885	360	32	peak	peak	NN
10_1101-2021_02_13_429885	360	33	at	at	IN
10_1101-2021_02_13_429885	360	34	VAF	VAF	NNP
10_1101-2021_02_13_429885	360	35	,	,	,
10_1101-2021_02_13_429885	360	36	for	for	IN
10_1101-2021_02_13_429885	360	37	a	a	DT
10_1101-2021_02_13_429885	360	38	given	give	VBN
10_1101-2021_02_13_429885	360	39	value	value	NN
10_1101-2021_02_13_429885	360	40	of	of	IN
10_1101-2021_02_13_429885	360	41	,	,	,
10_1101-2021_02_13_429885	360	42	in	in	IN
10_1101-2021_02_13_429885	360	43	the	the	DT
10_1101-2021_02_13_429885	360	44	data	data	NN
10_1101-2021_02_13_429885	360	45	distribution	distribution	NN
10_1101-2021_02_13_429885	360	46	(	(	-LRB-
10_1101-2021_02_13_429885	360	47	​Figure	​figure	NN
10_1101-2021_02_13_429885	360	48	1a	1a	CD
10_1101-2021_02_13_429885	360	49	and	and	CC
10_1101-2021_02_13_429885	360	50	​1b	​1b	NNP
10_1101-2021_02_13_429885	360	51	​	​	NNP
10_1101-2021_02_13_429885	360	52	)	)	-RRB-
10_1101-2021_02_13_429885	360	53	.	.	.
10_1101-2021_02_13_429885	361	1	For	for	IN
10_1101-2021_02_13_429885	361	2	instance	instance	NN
10_1101-2021_02_13_429885	361	3	,	,	,
10_1101-2021_02_13_429885	361	4	for	for	IN
10_1101-2021_02_13_429885	361	5	a	a	DT
10_1101-2021_02_13_429885	361	6	1:1	1:1	CD
10_1101-2021_02_13_429885	361	7	segment	segment	NN
10_1101-2021_02_13_429885	361	8	(	(	-LRB-
10_1101-2021_02_13_429885	361	9	)	)	-RRB-
10_1101-2021_02_13_429885	361	10	,	,	,
10_1101-2021_02_13_429885	361	11	the	the	DT
10_1101-2021_02_13_429885	361	12	expected	expect	VBN
10_1101-2021_02_13_429885	361	13	VAF	VAF	NNP
10_1101-2021_02_13_429885	361	14	for	for	IN
10_1101-2021_02_13_429885	361	15	a	a	DT
10_1101-2021_02_13_429885	361	16	heterozygous	heterozygous	JJ
10_1101-2021_02_13_429885	361	17	clonal	clonal	NN
10_1101-2021_02_13_429885	361	18	(	(	-LRB-
10_1101-2021_02_13_429885	361	19	)	)	-RRB-
10_1101-2021_02_13_429885	361	20	mutation	mutation	NN
10_1101-2021_02_13_429885	361	21	is	be	VBZ
10_1101-2021_02_13_429885	361	22	25	25	CD
10_1101-2021_02_13_429885	361	23	%	%	NN
10_1101-2021_02_13_429885	361	24	p	p	NN
10_1101-2021_02_13_429885	361	25	=	=	SYM
10_1101-2021_02_13_429885	361	26	2	2	CD
10_1101-2021_02_13_429885	361	27	m	m	NN
10_1101-2021_02_13_429885	361	28	=	=	SYM
10_1101-2021_02_13_429885	361	29	1	1	CD
10_1101-2021_02_13_429885	361	30	for	for	IN
10_1101-2021_02_13_429885	361	31	a	a	DT
10_1101-2021_02_13_429885	361	32	50%-purity	50%-purity	CD
10_1101-2021_02_13_429885	361	33	tumour	tumour	NN
10_1101-2021_02_13_429885	361	34	,	,	,
10_1101-2021_02_13_429885	361	35	and	and	CC
10_1101-2021_02_13_429885	361	36	50	50	CD
10_1101-2021_02_13_429885	361	37	%	%	NN
10_1101-2021_02_13_429885	361	38	for	for	IN
10_1101-2021_02_13_429885	361	39	a	a	DT
10_1101-2021_02_13_429885	361	40	100%-purity	100%-purity	CD
10_1101-2021_02_13_429885	361	41	tumour	tumour	NN
10_1101-2021_02_13_429885	361	42	.	.	.
10_1101-2021_02_13_429885	362	1	Similarly	similarly	RB
10_1101-2021_02_13_429885	362	2	,	,	,
10_1101-2021_02_13_429885	362	3	for	for	IN
10_1101-2021_02_13_429885	362	4	a	a	DT
10_1101-2021_02_13_429885	362	5	2:2	2:2	CD
10_1101-2021_02_13_429885	362	6	genome	genome	NN
10_1101-2021_02_13_429885	362	7	(	(	-LRB-
10_1101-2021_02_13_429885	362	8	)	)	-RRB-
10_1101-2021_02_13_429885	362	9	of	of	IN
10_1101-2021_02_13_429885	362	10	a	a	DT
10_1101-2021_02_13_429885	362	11	tumour	tumour	NN
10_1101-2021_02_13_429885	362	12	with	with	IN
10_1101-2021_02_13_429885	362	13	75	75	CD
10_1101-2021_02_13_429885	362	14	%	%	NN
10_1101-2021_02_13_429885	362	15	purity	purity	NN
10_1101-2021_02_13_429885	362	16	,	,	,
10_1101-2021_02_13_429885	362	17	the	the	DT
10_1101-2021_02_13_429885	362	18	expected	expect	VBN
10_1101-2021_02_13_429885	362	19	VAF	VAF	NNP
10_1101-2021_02_13_429885	362	20	for	for	IN
10_1101-2021_02_13_429885	362	21	clonal	clonal	JJ
10_1101-2021_02_13_429885	362	22	mutations	mutation	NNS
10_1101-2021_02_13_429885	362	23	accruedp	accruedp	VBP
10_1101-2021_02_13_429885	362	24	=	=	SYM
10_1101-2021_02_13_429885	362	25	4	4	CD
10_1101-2021_02_13_429885	362	26	before	before	IN
10_1101-2021_02_13_429885	362	27	genome	genome	JJ
10_1101-2021_02_13_429885	362	28	doubling	doubling	NN
10_1101-2021_02_13_429885	362	29	and	and	CC
10_1101-2021_02_13_429885	362	30	therefore	therefore	RB
10_1101-2021_02_13_429885	362	31	visible	visible	JJ
10_1101-2021_02_13_429885	362	32	in	in	IN
10_1101-2021_02_13_429885	362	33	two	two	CD
10_1101-2021_02_13_429885	362	34	copies	copy	NNS
10_1101-2021_02_13_429885	362	35	(	(	-LRB-
10_1101-2021_02_13_429885	362	36	)	)	-RRB-
10_1101-2021_02_13_429885	362	37	is	be	VBZ
10_1101-2021_02_13_429885	362	38	~54	~54	NFP
10_1101-2021_02_13_429885	362	39	%	%	NN
10_1101-2021_02_13_429885	362	40	,	,	,
10_1101-2021_02_13_429885	362	41	while	while	IN
10_1101-2021_02_13_429885	362	42	for	for	IN
10_1101-2021_02_13_429885	362	43	m	m	NN
10_1101-2021_02_13_429885	362	44	=	=	SYM
10_1101-2021_02_13_429885	362	45	2	2	CD
10_1101-2021_02_13_429885	362	46	those	those	DT
10_1101-2021_02_13_429885	362	47	accrued	accrue	VBN
10_1101-2021_02_13_429885	362	48	after	after	IN
10_1101-2021_02_13_429885	362	49	genome	genome	JJ
10_1101-2021_02_13_429885	362	50	doubling	doubling	NN
10_1101-2021_02_13_429885	362	51	,	,	,
10_1101-2021_02_13_429885	362	52	and	and	CC
10_1101-2021_02_13_429885	362	53	therefore	therefore	RB
10_1101-2021_02_13_429885	362	54	present	present	JJ
10_1101-2021_02_13_429885	362	55	in	in	IN
10_1101-2021_02_13_429885	362	56	single	single	JJ
10_1101-2021_02_13_429885	362	57	copy	copy	NN
10_1101-2021_02_13_429885	362	58	(	(	-LRB-
10_1101-2021_02_13_429885	362	59	)	)	-RRB-
10_1101-2021_02_13_429885	362	60	,	,	,
10_1101-2021_02_13_429885	362	61	we	-PRON-	PRP
10_1101-2021_02_13_429885	362	62	m	m	NN
10_1101-2021_02_13_429885	362	63	=	=	SYM
10_1101-2021_02_13_429885	362	64	1	1	CD
10_1101-2021_02_13_429885	362	65	expect	expect	VB
10_1101-2021_02_13_429885	362	66	a	a	DT
10_1101-2021_02_13_429885	362	67	~21	~21	NNP
10_1101-2021_02_13_429885	362	68	%	%	NN
10_1101-2021_02_13_429885	362	69	VAF	VAF	NNP
10_1101-2021_02_13_429885	362	70	​(Dentro	​(Dentro	NNP
10_1101-2021_02_13_429885	362	71	,	,	,
10_1101-2021_02_13_429885	362	72	Wedge	Wedge	NNP
10_1101-2021_02_13_429885	362	73	,	,	,
10_1101-2021_02_13_429885	362	74	and	and	CC
10_1101-2021_02_13_429885	362	75	Van	Van	NNP
10_1101-2021_02_13_429885	362	76	Loo	Loo	NNP
10_1101-2021_02_13_429885	362	77	2017)​.	2017)​.	CD
10_1101-2021_02_13_429885	363	1	CNAqc	cnaqc	NN
10_1101-2021_02_13_429885	363	2	checks	check	VBZ
10_1101-2021_02_13_429885	363	3	the	the	DT
10_1101-2021_02_13_429885	363	4	data	datum	NNS
10_1101-2021_02_13_429885	363	5	for	for	IN
10_1101-2021_02_13_429885	363	6	peaks	peak	NNS
10_1101-2021_02_13_429885	363	7	at	at	IN
10_1101-2021_02_13_429885	363	8	these	these	DT
10_1101-2021_02_13_429885	363	9	VAFs	vaf	NNS
10_1101-2021_02_13_429885	363	10	,	,	,
10_1101-2021_02_13_429885	363	11	with	with	IN
10_1101-2021_02_13_429885	363	12	a	a	DT
10_1101-2021_02_13_429885	363	13	tolerance	tolerance	NN
10_1101-2021_02_13_429885	363	14	.	.	.
10_1101-2021_02_13_429885	364	1	From	from	IN
10_1101-2021_02_13_429885	364	2	the	the	DT
10_1101-2021_02_13_429885	364	3	distance	distance	NN
10_1101-2021_02_13_429885	364	4	between	between	IN
10_1101-2021_02_13_429885	364	5	the	the	DT
10_1101-2021_02_13_429885	364	6	theoretical	theoretical	JJ
10_1101-2021_02_13_429885	364	7	expectation	expectation	NN
10_1101-2021_02_13_429885	364	8	and	and	CC
10_1101-2021_02_13_429885	364	9	the	the	DT
10_1101-2021_02_13_429885	364	10	estimator	estimator	NN
10_1101-2021_02_13_429885	364	11	derived	derive	VBN
10_1101-2021_02_13_429885	364	12	from	from	IN
10_1101-2021_02_13_429885	364	13	data	datum	NNS
10_1101-2021_02_13_429885	364	14	,	,	,
10_1101-2021_02_13_429885	364	15	we	-PRON-	PRP
10_1101-2021_02_13_429885	364	16	obtain	obtain	VBP
10_1101-2021_02_13_429885	364	17	an	an	DT
10_1101-2021_02_13_429885	364	18	error	error	NN
10_1101-2021_02_13_429885	364	19	metric	metric	JJ
10_1101-2021_02_13_429885	364	20	for	for	IN
10_1101-2021_02_13_429885	364	21	the	the	DT
10_1101-2021_02_13_429885	364	22	calls	call	NNS
10_1101-2021_02_13_429885	364	23	.	.	.
10_1101-2021_02_13_429885	365	1	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	365	2	first	first	RB
10_1101-2021_02_13_429885	365	3	performs	perform	VBZ
10_1101-2021_02_13_429885	365	4	peak	peak	NN
10_1101-2021_02_13_429885	365	5	detection	detection	NN
10_1101-2021_02_13_429885	365	6	from	from	IN
10_1101-2021_02_13_429885	365	7	the	the	DT
10_1101-2021_02_13_429885	365	8	input	input	NN
10_1101-2021_02_13_429885	365	9	VAF	VAF	NNP
10_1101-2021_02_13_429885	365	10	with	with	IN
10_1101-2021_02_13_429885	365	11	two	two	CD
10_1101-2021_02_13_429885	365	12	,	,	,
10_1101-2021_02_13_429885	365	13	separate	separate	JJ
10_1101-2021_02_13_429885	365	14	,	,	,
10_1101-2021_02_13_429885	365	15	methods	method	NNS
10_1101-2021_02_13_429885	365	16	:	:	:
10_1101-2021_02_13_429885	365	17	1	1	CD
10_1101-2021_02_13_429885	365	18	.	.	.
10_1101-2021_02_13_429885	366	1	Via	via	IN
10_1101-2021_02_13_429885	366	2	a	a	DT
10_1101-2021_02_13_429885	366	3	kernel	kernel	NN
10_1101-2021_02_13_429885	366	4	density	density	NN
10_1101-2021_02_13_429885	366	5	estimation	estimation	NN
10_1101-2021_02_13_429885	366	6	with	with	IN
10_1101-2021_02_13_429885	366	7	fixed	fix	VBN
10_1101-2021_02_13_429885	366	8	bandwidth	bandwidth	NN
10_1101-2021_02_13_429885	366	9	,	,	,
10_1101-2021_02_13_429885	366	10	which	which	WDT
10_1101-2021_02_13_429885	366	11	is	be	VBZ
10_1101-2021_02_13_429885	366	12	used	use	VBN
10_1101-2021_02_13_429885	366	13	to	to	TO
10_1101-2021_02_13_429885	366	14	determine	determine	VB
10_1101-2021_02_13_429885	366	15	a	a	DT
10_1101-2021_02_13_429885	366	16	smooth	smooth	JJ
10_1101-2021_02_13_429885	366	17	density	density	NN
10_1101-2021_02_13_429885	366	18	profile	profile	NN
10_1101-2021_02_13_429885	366	19	.	.	.
10_1101-2021_02_13_429885	367	1	Peaks	peak	NNS
10_1101-2021_02_13_429885	367	2	are	be	VBP
10_1101-2021_02_13_429885	367	3	then	then	RB
10_1101-2021_02_13_429885	367	4	estimated	estimate	VBN
10_1101-2021_02_13_429885	367	5	from	from	IN
10_1101-2021_02_13_429885	367	6	the	the	DT
10_1101-2021_02_13_429885	367	7	discretized	discretized	JJ
10_1101-2021_02_13_429885	367	8	smooth	smooth	NN
10_1101-2021_02_13_429885	367	9	,	,	,
10_1101-2021_02_13_429885	367	10	using	use	VBG
10_1101-2021_02_13_429885	367	11	specialised	specialise	VBN
10_1101-2021_02_13_429885	367	12	R	r	NN
10_1101-2021_02_13_429885	367	13	packages	package	NNS
10_1101-2021_02_13_429885	367	14	for	for	IN
10_1101-2021_02_13_429885	367	15	peak	peak	NN
10_1101-2021_02_13_429885	367	16	-	-	HYPH
10_1101-2021_02_13_429885	367	17	detection	detection	NN
10_1101-2021_02_13_429885	367	18	and	and	CC
10_1101-2021_02_13_429885	367	19	removing	remove	VBG
10_1101-2021_02_13_429885	367	20	peaks	peak	NNS
10_1101-2021_02_13_429885	367	21	with	with	IN
10_1101-2021_02_13_429885	367	22	density	density	NN
10_1101-2021_02_13_429885	367	23	below	below	IN
10_1101-2021_02_13_429885	367	24	a	a	DT
10_1101-2021_02_13_429885	367	25	parameterized	parameterize	VBN
10_1101-2021_02_13_429885	367	26	cutoff	cutoff	NN
10_1101-2021_02_13_429885	367	27	.	.	.
10_1101-2021_02_13_429885	368	1	2	2	LS
10_1101-2021_02_13_429885	368	2	.	.	.
10_1101-2021_02_13_429885	369	1	Via	Via	NNP
10_1101-2021_02_13_429885	369	2	Binomial	Binomial	NNP
10_1101-2021_02_13_429885	369	3	mixture	mixture	NN
10_1101-2021_02_13_429885	369	4	from	from	IN
10_1101-2021_02_13_429885	369	5	the	the	DT
10_1101-2021_02_13_429885	369	6	BMix	BMix	NNP
10_1101-2021_02_13_429885	369	7	​(Caravagna	​(Caravagna	NNP
10_1101-2021_02_13_429885	369	8	et	et	NNP
10_1101-2021_02_13_429885	369	9	al	al	NNP
10_1101-2021_02_13_429885	369	10	.	.	.
10_1101-2021_02_13_429885	370	1	2020	2020	LS
10_1101-2021_02_13_429885	370	2	)	)	-RRB-
10_1101-2021_02_13_429885	370	3	package	package	NN
10_1101-2021_02_13_429885	370	4	(	(	-LRB-
10_1101-2021_02_13_429885	370	5	​https://caravagn.github.io	​https://caravagn.github.io	NNP
10_1101-2021_02_13_429885	370	6	/	/	SYM
10_1101-2021_02_13_429885	370	7	BMix/​	BMix/​	NNP
10_1101-2021_02_13_429885	370	8	)	)	-RRB-
10_1101-2021_02_13_429885	370	9	,	,	,
10_1101-2021_02_13_429885	370	10	a	a	DT
10_1101-2021_02_13_429885	370	11	peak	peak	NN
10_1101-2021_02_13_429885	370	12	is	be	VBZ
10_1101-2021_02_13_429885	370	13	associated	associate	VBN
10_1101-2021_02_13_429885	370	14	with	with	IN
10_1101-2021_02_13_429885	370	15	each	each	DT
10_1101-2021_02_13_429885	370	16	Binomial	binomial	JJ
10_1101-2021_02_13_429885	370	17	probability	probability	NN
10_1101-2021_02_13_429885	370	18	,	,	,
10_1101-2021_02_13_429885	370	19	for	for	IN
10_1101-2021_02_13_429885	370	20	all	all	DT
10_1101-2021_02_13_429885	370	21	mixture	mixture	NN
10_1101-2021_02_13_429885	370	22	components	component	NNS
10_1101-2021_02_13_429885	370	23	.	.	.
10_1101-2021_02_13_429885	371	1	Peaks	peak	NNS
10_1101-2021_02_13_429885	371	2	are	be	VBP
10_1101-2021_02_13_429885	371	3	matched	match	VBN
10_1101-2021_02_13_429885	371	4	to	to	IN
10_1101-2021_02_13_429885	371	5	the	the	DT
10_1101-2021_02_13_429885	371	6	expected	expect	VBN
10_1101-2021_02_13_429885	371	7	theoretical	theoretical	JJ
10_1101-2021_02_13_429885	371	8	values	value	NNS
10_1101-2021_02_13_429885	371	9	based	base	VBN
10_1101-2021_02_13_429885	371	10	on	on	IN
10_1101-2021_02_13_429885	371	11	their	-PRON-	PRP$
10_1101-2021_02_13_429885	371	12	euclidean	euclidean	JJ
10_1101-2021_02_13_429885	371	13	distance	distance	NN
10_1101-2021_02_13_429885	371	14	.	.	.
10_1101-2021_02_13_429885	372	1	A	a	DT
10_1101-2021_02_13_429885	372	2	theoretical	theoretical	JJ
10_1101-2021_02_13_429885	372	3	peak	peak	NN
10_1101-2021_02_13_429885	372	4	can	can	MD
10_1101-2021_02_13_429885	372	5	be	be	VB
10_1101-2021_02_13_429885	372	6	matched	match	VBN
10_1101-2021_02_13_429885	372	7	to	to	IN
10_1101-2021_02_13_429885	372	8	the	the	DT
10_1101-2021_02_13_429885	372	9	closest	close	JJS
10_1101-2021_02_13_429885	372	10	peak	peak	NN
10_1101-2021_02_13_429885	372	11	in	in	IN
10_1101-2021_02_13_429885	372	12	the	the	DT
10_1101-2021_02_13_429885	372	13	data	datum	NNS
10_1101-2021_02_13_429885	372	14	,	,	,
10_1101-2021_02_13_429885	372	15	or	or	CC
10_1101-2021_02_13_429885	372	16	the	the	DT
10_1101-2021_02_13_429885	372	17	one	one	NN
10_1101-2021_02_13_429885	372	18	to	to	IN
10_1101-2021_02_13_429885	372	19	the	the	DT
10_1101-2021_02_13_429885	372	20	most	most	RBS
10_1101-2021_02_13_429885	372	21	right	right	JJ
10_1101-2021_02_13_429885	372	22	side	side	NN
10_1101-2021_02_13_429885	372	23	of	of	IN
10_1101-2021_02_13_429885	372	24	the	the	DT
10_1101-2021_02_13_429885	372	25	frequency	frequency	NN
10_1101-2021_02_13_429885	372	26	spectrum	spectrum	NN
10_1101-2021_02_13_429885	372	27	.	.	.
10_1101-2021_02_13_429885	373	1	This	this	DT
10_1101-2021_02_13_429885	373	2	latter	latter	JJ
10_1101-2021_02_13_429885	373	3	strategy	strategy	NN
10_1101-2021_02_13_429885	373	4	works	work	VBZ
10_1101-2021_02_13_429885	373	5	only	only	RB
10_1101-2021_02_13_429885	373	6	if	if	IN
10_1101-2021_02_13_429885	373	7	there	there	EX
10_1101-2021_02_13_429885	373	8	are	be	VBP
10_1101-2021_02_13_429885	373	9	no	no	DT
10_1101-2021_02_13_429885	373	10	miscalled	miscalled	JJ
10_1101-2021_02_13_429885	373	11	CNAs	cna	NNS
10_1101-2021_02_13_429885	373	12	.	.	.
10_1101-2021_02_13_429885	374	1	The	the	DT
10_1101-2021_02_13_429885	374	2	first	first	JJ
10_1101-2021_02_13_429885	374	3	strategy	strategy	NN
10_1101-2021_02_13_429885	374	4	(	(	-LRB-
10_1101-2021_02_13_429885	374	5	closest	close	JJS
10_1101-2021_02_13_429885	374	6	match	match	NN
10_1101-2021_02_13_429885	374	7	)	)	-RRB-
10_1101-2021_02_13_429885	374	8	,	,	,
10_1101-2021_02_13_429885	374	9	is	be	VBZ
10_1101-2021_02_13_429885	374	10	the	the	DT
10_1101-2021_02_13_429885	374	11	default	default	NN
10_1101-2021_02_13_429885	374	12	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	374	13	choice	choice	NN
10_1101-2021_02_13_429885	374	14	.	.	.
10_1101-2021_02_13_429885	375	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	375	2	-	-	:
10_1101-2021_02_13_429885	375	3	BY	by	IN
10_1101-2021_02_13_429885	375	4	-	-	HYPH
10_1101-2021_02_13_429885	375	5	NC	NC	NNP
10_1101-2021_02_13_429885	375	6	-	-	HYPH
10_1101-2021_02_13_429885	375	7	ND	ND	NNP
10_1101-2021_02_13_429885	375	8	4.0	4.0	CD
10_1101-2021_02_13_429885	375	9	International	International	NNP
10_1101-2021_02_13_429885	375	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	375	11	under	under	IN
10_1101-2021_02_13_429885	375	12	a	a	DT
10_1101-2021_02_13_429885	375	13	(	(	-LRB-
10_1101-2021_02_13_429885	375	14	which	which	WDT
10_1101-2021_02_13_429885	375	15	was	be	VBD
10_1101-2021_02_13_429885	375	16	not	not	RB
10_1101-2021_02_13_429885	375	17	certified	certify	VBN
10_1101-2021_02_13_429885	375	18	by	by	IN
10_1101-2021_02_13_429885	375	19	peer	peer	NN
10_1101-2021_02_13_429885	375	20	review	review	NN
10_1101-2021_02_13_429885	375	21	)	)	-RRB-
10_1101-2021_02_13_429885	375	22	is	be	VBZ
10_1101-2021_02_13_429885	375	23	the	the	DT
10_1101-2021_02_13_429885	375	24	author	author	NN
10_1101-2021_02_13_429885	375	25	/	/	SYM
10_1101-2021_02_13_429885	375	26	funder	funder	NN
10_1101-2021_02_13_429885	375	27	,	,	,
10_1101-2021_02_13_429885	375	28	who	who	WP
10_1101-2021_02_13_429885	375	29	has	have	VBZ
10_1101-2021_02_13_429885	375	30	granted	grant	VBN
10_1101-2021_02_13_429885	375	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	375	32	a	a	DT
10_1101-2021_02_13_429885	375	33	license	license	NN
10_1101-2021_02_13_429885	375	34	to	to	TO
10_1101-2021_02_13_429885	375	35	display	display	VB
10_1101-2021_02_13_429885	375	36	the	the	DT
10_1101-2021_02_13_429885	375	37	preprint	preprint	NN
10_1101-2021_02_13_429885	375	38	in	in	IN
10_1101-2021_02_13_429885	375	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	375	40	.	.	.
10_1101-2021_02_13_429885	376	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	376	2	is	be	VBZ
10_1101-2021_02_13_429885	376	3	made	make	VBN
10_1101-2021_02_13_429885	376	4	The	the	DT
10_1101-2021_02_13_429885	376	5	copyright	copyright	NN
10_1101-2021_02_13_429885	376	6	holder	holder	NN
10_1101-2021_02_13_429885	376	7	for	for	IN
10_1101-2021_02_13_429885	376	8	this	this	DT
10_1101-2021_02_13_429885	376	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	376	10	version	version	NN
10_1101-2021_02_13_429885	376	11	posted	post	VBD
10_1101-2021_02_13_429885	376	12	February	February	NNP
10_1101-2021_02_13_429885	376	13	13	13	CD
10_1101-2021_02_13_429885	376	14	,	,	,
10_1101-2021_02_13_429885	376	15	2021	2021	CD
10_1101-2021_02_13_429885	376	16	.	.	.
10_1101-2021_02_13_429885	376	17	;	;	:
10_1101-2021_02_13_429885	376	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	376	19	:	:	:
10_1101-2021_02_13_429885	376	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	376	21	preprint	preprint	NN
10_1101-2021_02_13_429885	376	22	https://www.codecogs.com/eqnedit.php?latex=m#0	https://www.codecogs.com/eqnedit.php?latex=m#0	NNP
10_1101-2021_02_13_429885	376	23	https://www.codecogs.com/eqnedit.php?latex=%5Cpi#0	https://www.codecogs.com/eqnedit.php?latex=%5Cpi#0	NNP
10_1101-2021_02_13_429885	376	24	https://www.codecogs.com/eqnedit.php?latex=v#0	https://www.codecogs.com/eqnedit.php?latex=v#0	NNP
10_1101-2021_02_13_429885	376	25	https://www.codecogs.com/eqnedit.php?latex=v%20%3D%20%5Cdfrac%7Bv%5B(p-2)%5Cpi%20%2B%202%5D%7D%7Bm%5Cpi%7D%20#0	https://www.codecogs.com/eqnedit.php?latex=v%20%3D%20%5Cdfrac%7Bv%5B(p-2)%5Cpi%20%2B%202%5D%7D%7Bm%5Cpi%7D%20#0	NNP
10_1101-2021_02_13_429885	376	26	https://www.codecogs.com/eqnedit.php?latex=v#0	https://www.codecogs.com/eqnedit.php?latex=v#0	NNP
10_1101-2021_02_13_429885	376	27	https://www.codecogs.com/eqnedit.php?latex=m#0	https://www.codecogs.com/eqnedit.php?latex=m#0	NNP
10_1101-2021_02_13_429885	376	28	https://paperpile.com/c/rqVmzs/Uxwc	https://paperpile.com/c/rqvmzs/uxwc	JJ
10_1101-2021_02_13_429885	376	29	https://www.codecogs.com/eqnedit.php?latex=%5Cepsilon%3E0#0	https://www.codecogs.com/eqnedit.php?latex=%5cepsilon%3e0#0	NN
10_1101-2021_02_13_429885	376	30	https://paperpile.com/c/rqVmzs/chqB	https://paperpile.com/c/rqVmzs/chqB	NNP
10_1101-2021_02_13_429885	376	31	https://caravagn.github.io/BMix/	https://caravagn.github.io/bmix/	JJ
10_1101-2021_02_13_429885	376	32	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	NNP
10_1101-2021_02_13_429885	376	33	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	376	34	Househam	Househam	NNP
10_1101-2021_02_13_429885	376	35	et	et	FW
10_1101-2021_02_13_429885	376	36	al	al	NNP
10_1101-2021_02_13_429885	376	37	.	.	.
10_1101-2021_02_13_429885	377	1	A	a	DT
10_1101-2021_02_13_429885	377	2	fully	fully	RB
10_1101-2021_02_13_429885	377	3	automated	automate	VBN
10_1101-2021_02_13_429885	377	4	approach	approach	NN
10_1101-2021_02_13_429885	377	5	for	for	IN
10_1101-2021_02_13_429885	377	6	quality	quality	NN
10_1101-2021_02_13_429885	377	7	control	control	NN
10_1101-2021_02_13_429885	377	8	of	of	IN
10_1101-2021_02_13_429885	377	9	cancer	cancer	NN
10_1101-2021_02_13_429885	377	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	377	11	in	in	IN
10_1101-2021_02_13_429885	377	12	the	the	DT
10_1101-2021_02_13_429885	377	13	era	era	NN
10_1101-2021_02_13_429885	377	14	of	of	IN
10_1101-2021_02_13_429885	377	15	high	high	JJ
10_1101-2021_02_13_429885	377	16	-	-	HYPH
10_1101-2021_02_13_429885	377	17	resolution	resolution	NN
10_1101-2021_02_13_429885	377	18	whole	whole	JJ
10_1101-2021_02_13_429885	377	19	genome	genome	JJ
10_1101-2021_02_13_429885	377	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	377	21	.	.	.
10_1101-2021_02_13_429885	378	1	For	for	IN
10_1101-2021_02_13_429885	378	2	every	every	DT
10_1101-2021_02_13_429885	378	3	peak	peak	NN
10_1101-2021_02_13_429885	378	4	a	a	DT
10_1101-2021_02_13_429885	378	5	QC	QC	NNP
10_1101-2021_02_13_429885	378	6	value	value	NN
10_1101-2021_02_13_429885	378	7	(	(	-LRB-
10_1101-2021_02_13_429885	378	8	PASS	pas	NNS
10_1101-2021_02_13_429885	378	9	or	or	CC
10_1101-2021_02_13_429885	378	10	FAIL	FAIL	NNP
10_1101-2021_02_13_429885	378	11	)	)	-RRB-
10_1101-2021_02_13_429885	378	12	is	be	VBZ
10_1101-2021_02_13_429885	378	13	determined	determine	VBN
10_1101-2021_02_13_429885	378	14	based	base	VBN
10_1101-2021_02_13_429885	378	15	on	on	IN
10_1101-2021_02_13_429885	378	16	some	some	DT
10_1101-2021_02_13_429885	378	17	tolerance	tolerance	NN
10_1101-2021_02_13_429885	378	18	.	.	.
10_1101-2021_02_13_429885	379	1	The	the	DT
10_1101-2021_02_13_429885	379	2	overall	overall	JJ
10_1101-2021_02_13_429885	379	3	QC	QC	NNP
10_1101-2021_02_13_429885	379	4	status	status	NN
10_1101-2021_02_13_429885	379	5	of	of	IN
10_1101-2021_02_13_429885	379	6	copy	copy	NN
10_1101-2021_02_13_429885	379	7	states	state	NNS
10_1101-2021_02_13_429885	379	8	with	with	IN
10_1101-2021_02_13_429885	379	9	multiple	multiple	JJ
10_1101-2021_02_13_429885	379	10	peaks	peak	NNS
10_1101-2021_02_13_429885	379	11	is	be	VBZ
10_1101-2021_02_13_429885	379	12	the	the	DT
10_1101-2021_02_13_429885	379	13	QC	QC	NNP
10_1101-2021_02_13_429885	379	14	of	of	IN
10_1101-2021_02_13_429885	379	15	the	the	DT
10_1101-2021_02_13_429885	379	16	peakε	peakε	NN
10_1101-2021_02_13_429885	379	17	>	>	XX
10_1101-2021_02_13_429885	379	18	0	0	CD
10_1101-2021_02_13_429885	379	19	with	with	IN
10_1101-2021_02_13_429885	379	20	most	most	JJS
10_1101-2021_02_13_429885	379	21	mutations	mutation	NNS
10_1101-2021_02_13_429885	379	22	underneath	underneath	RB
10_1101-2021_02_13_429885	379	23	.	.	.
10_1101-2021_02_13_429885	380	1	The	the	DT
10_1101-2021_02_13_429885	380	2	overall	overall	JJ
10_1101-2021_02_13_429885	380	3	QC	QC	NNP
10_1101-2021_02_13_429885	380	4	status	status	NN
10_1101-2021_02_13_429885	380	5	for	for	IN
10_1101-2021_02_13_429885	380	6	a	a	DT
10_1101-2021_02_13_429885	380	7	sample	sample	NN
10_1101-2021_02_13_429885	380	8	with	with	IN
10_1101-2021_02_13_429885	380	9	many	many	JJ
10_1101-2021_02_13_429885	380	10	copy	copy	NN
10_1101-2021_02_13_429885	380	11	states	state	NNS
10_1101-2021_02_13_429885	380	12	is	be	VBZ
10_1101-2021_02_13_429885	380	13	determined	determine	VBN
10_1101-2021_02_13_429885	380	14	by	by	IN
10_1101-2021_02_13_429885	380	15	summing	sum	VBG
10_1101-2021_02_13_429885	380	16	up	up	RP
10_1101-2021_02_13_429885	380	17	the	the	DT
10_1101-2021_02_13_429885	380	18	QC	QC	NNP
10_1101-2021_02_13_429885	380	19	status	status	NN
10_1101-2021_02_13_429885	380	20	of	of	IN
10_1101-2021_02_13_429885	380	21	individual	individual	JJ
10_1101-2021_02_13_429885	380	22	copy	copy	NN
10_1101-2021_02_13_429885	380	23	states	state	NNS
10_1101-2021_02_13_429885	380	24	,	,	,
10_1101-2021_02_13_429885	380	25	and	and	CC
10_1101-2021_02_13_429885	380	26	weighting	weight	VBG
10_1101-2021_02_13_429885	380	27	them	-PRON-	PRP
10_1101-2021_02_13_429885	380	28	by	by	IN
10_1101-2021_02_13_429885	380	29	the	the	DT
10_1101-2021_02_13_429885	380	30	number	number	NN
10_1101-2021_02_13_429885	380	31	of	of	IN
10_1101-2021_02_13_429885	380	32	mutations	mutation	NNS
10_1101-2021_02_13_429885	380	33	associated	associate	VBN
10_1101-2021_02_13_429885	380	34	(	(	-LRB-
10_1101-2021_02_13_429885	380	35	majority	majority	NNP
10_1101-2021_02_13_429885	380	36	rule	rule	NN
10_1101-2021_02_13_429885	380	37	)	)	-RRB-
10_1101-2021_02_13_429885	380	38	.	.	.
10_1101-2021_02_13_429885	381	1	CCF	ccf	NN
10_1101-2021_02_13_429885	381	2	estimation	estimation	NN
10_1101-2021_02_13_429885	381	3	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	381	4	can	can	MD
10_1101-2021_02_13_429885	381	5	compute	compute	VB
10_1101-2021_02_13_429885	381	6	CCFs	ccf	NNS
10_1101-2021_02_13_429885	381	7	in	in	IN
10_1101-2021_02_13_429885	381	8	two	two	CD
10_1101-2021_02_13_429885	381	9	ways	way	NNS
10_1101-2021_02_13_429885	381	10	.	.	.
10_1101-2021_02_13_429885	382	1	One	one	CD
10_1101-2021_02_13_429885	382	2	of	of	IN
10_1101-2021_02_13_429885	382	3	the	the	DT
10_1101-2021_02_13_429885	382	4	two	two	CD
10_1101-2021_02_13_429885	382	5	uses	use	VBZ
10_1101-2021_02_13_429885	382	6	the	the	DT
10_1101-2021_02_13_429885	382	7	idea	idea	NN
10_1101-2021_02_13_429885	382	8	of	of	IN
10_1101-2021_02_13_429885	382	9	the	the	DT
10_1101-2021_02_13_429885	382	10	mixture	mixture	NN
10_1101-2021_02_13_429885	382	11	highlighted	highlight	VBN
10_1101-2021_02_13_429885	382	12	in	in	IN
10_1101-2021_02_13_429885	382	13	​Figure	​figure	NN
10_1101-2021_02_13_429885	382	14	1c	1c	CD
10_1101-2021_02_13_429885	382	15	​	​	NNP
10_1101-2021_02_13_429885	382	16	,	,	,
10_1101-2021_02_13_429885	382	17	the	the	DT
10_1101-2021_02_13_429885	382	18	other	other	JJ
10_1101-2021_02_13_429885	382	19	is	be	VBZ
10_1101-2021_02_13_429885	382	20	simpler	simple	JJR
10_1101-2021_02_13_429885	382	21	and	and	CC
10_1101-2021_02_13_429885	382	22	works	work	VBZ
10_1101-2021_02_13_429885	382	23	better	well	RBR
10_1101-2021_02_13_429885	382	24	when	when	WRB
10_1101-2021_02_13_429885	382	25	data	datum	NNS
10_1101-2021_02_13_429885	382	26	resolution	resolution	NN
10_1101-2021_02_13_429885	382	27	is	be	VBZ
10_1101-2021_02_13_429885	382	28	low	low	JJ
10_1101-2021_02_13_429885	382	29	,	,	,
10_1101-2021_02_13_429885	382	30	and	and	CC
10_1101-2021_02_13_429885	382	31	the	the	DT
10_1101-2021_02_13_429885	382	32	entropy	entropy	JJ
10_1101-2021_02_13_429885	382	33	of	of	IN
10_1101-2021_02_13_429885	382	34	the	the	DT
10_1101-2021_02_13_429885	382	35	mixture	mixture	NN
10_1101-2021_02_13_429885	382	36	model	model	NN
10_1101-2021_02_13_429885	382	37	would	would	MD
10_1101-2021_02_13_429885	382	38	leave	leave	VB
10_1101-2021_02_13_429885	382	39	too	too	RB
10_1101-2021_02_13_429885	382	40	many	many	JJ
10_1101-2021_02_13_429885	382	41	mutations	mutation	NNS
10_1101-2021_02_13_429885	382	42	unassigned	unassigne	VBN
10_1101-2021_02_13_429885	382	43	.	.	.
10_1101-2021_02_13_429885	383	1	For	for	IN
10_1101-2021_02_13_429885	383	2	the	the	DT
10_1101-2021_02_13_429885	383	3	mixture	mixture	NN
10_1101-2021_02_13_429885	383	4	approach	approach	NN
10_1101-2021_02_13_429885	383	5	,	,	,
10_1101-2021_02_13_429885	383	6	we	-PRON-	PRP
10_1101-2021_02_13_429885	383	7	build	build	VBP
10_1101-2021_02_13_429885	383	8	a	a	DT
10_1101-2021_02_13_429885	383	9	2-components	2-components	CD
10_1101-2021_02_13_429885	383	10	Binomial	Binomial	NNP
10_1101-2021_02_13_429885	383	11	mixture	mixture	NN
10_1101-2021_02_13_429885	383	12	from	from	IN
10_1101-2021_02_13_429885	383	13	the	the	DT
10_1101-2021_02_13_429885	383	14	theoretical	theoretical	JJ
10_1101-2021_02_13_429885	383	15	expectations	expectation	NNS
10_1101-2021_02_13_429885	383	16	and	and	CC
10_1101-2021_02_13_429885	383	17	the	the	DT
10_1101-2021_02_13_429885	383	18	data	datum	NNS
10_1101-2021_02_13_429885	383	19	.	.	.
10_1101-2021_02_13_429885	384	1	This	this	DT
10_1101-2021_02_13_429885	384	2	implicitly	implicitly	RB
10_1101-2021_02_13_429885	384	3	assumes	assume	VBZ
10_1101-2021_02_13_429885	384	4	that	that	IN
10_1101-2021_02_13_429885	384	5	peaks	peak	NNS
10_1101-2021_02_13_429885	384	6	have	have	VBP
10_1101-2021_02_13_429885	384	7	been	be	VBN
10_1101-2021_02_13_429885	384	8	QCed	QCed	NNP
10_1101-2021_02_13_429885	384	9	first	first	RB
10_1101-2021_02_13_429885	384	10	.	.	.
10_1101-2021_02_13_429885	385	1	We	-PRON-	PRP
10_1101-2021_02_13_429885	385	2	constraint	constraint	VBP
10_1101-2021_02_13_429885	385	3	the	the	DT
10_1101-2021_02_13_429885	385	4	success	success	NN
10_1101-2021_02_13_429885	385	5	parameters	parameter	NNS
10_1101-2021_02_13_429885	385	6	to	to	TO
10_1101-2021_02_13_429885	385	7	match	match	VB
10_1101-2021_02_13_429885	385	8	the	the	DT
10_1101-2021_02_13_429885	385	9	expected	expect	VBN
10_1101-2021_02_13_429885	385	10	VAF	VAF	NNP
10_1101-2021_02_13_429885	385	11	,	,	,
10_1101-2021_02_13_429885	385	12	and	and	CC
10_1101-2021_02_13_429885	385	13	use	use	VB
10_1101-2021_02_13_429885	385	14	the	the	DT
10_1101-2021_02_13_429885	385	15	proportion	proportion	NN
10_1101-2021_02_13_429885	385	16	of	of	IN
10_1101-2021_02_13_429885	385	17	mutations	mutation	NNS
10_1101-2021_02_13_429885	385	18	that	that	WDT
10_1101-2021_02_13_429885	385	19	appear	appear	VBP
10_1101-2021_02_13_429885	385	20	underneath	underneath	IN
10_1101-2021_02_13_429885	385	21	a	a	DT
10_1101-2021_02_13_429885	385	22	peak	peak	NN
10_1101-2021_02_13_429885	385	23	as	as	IN
10_1101-2021_02_13_429885	385	24	mixing	mix	VBG
10_1101-2021_02_13_429885	385	25	proportions	proportion	NNS
10_1101-2021_02_13_429885	385	26	.	.	.
10_1101-2021_02_13_429885	386	1	π	π	LS
10_1101-2021_02_13_429885	386	2	Then	then	RB
10_1101-2021_02_13_429885	386	3	,	,	,
10_1101-2021_02_13_429885	386	4	from	from	IN
10_1101-2021_02_13_429885	386	5	the	the	DT
10_1101-2021_02_13_429885	386	6	latent	latent	NN
10_1101-2021_02_13_429885	386	7	variables	variable	NNS
10_1101-2021_02_13_429885	386	8	of	of	IN
10_1101-2021_02_13_429885	386	9	the	the	DT
10_1101-2021_02_13_429885	386	10	model	model	NN
10_1101-2021_02_13_429885	386	11	we	-PRON-	PRP
10_1101-2021_02_13_429885	386	12	compute	compute	VBP
10_1101-2021_02_13_429885	386	13	the	the	DT
10_1101-2021_02_13_429885	386	14	probability	probability	NN
10_1101-2021_02_13_429885	386	15	of	of	IN
10_1101-2021_02_13_429885	386	16	assigning	assign	VBG
10_1101-2021_02_13_429885	386	17	a	a	DT
10_1101-2021_02_13_429885	386	18	z	z	NN
10_1101-2021_02_13_429885	386	19	mutation	mutation	NN
10_1101-2021_02_13_429885	386	20	with	with	IN
10_1101-2021_02_13_429885	386	21	VAF	VAF	NNP
10_1101-2021_02_13_429885	386	22	to	to	TO
10_1101-2021_02_13_429885	386	23	cluster	cluster	VB
10_1101-2021_02_13_429885	386	24	,	,	,
10_1101-2021_02_13_429885	386	25	xn	xn	NNP
10_1101-2021_02_13_429885	386	26	c	c	NNP
10_1101-2021_02_13_429885	386	27	.	.	.
10_1101-2021_02_13_429885	387	1	(	(	-LRB-
10_1101-2021_02_13_429885	387	2	z	z	NNP
10_1101-2021_02_13_429885	387	3	|	|	NNP
10_1101-2021_02_13_429885	387	4	θ	θ	NNP
10_1101-2021_02_13_429885	387	5	,	,	,
10_1101-2021_02_13_429885	387	6	)	)	-RRB-
10_1101-2021_02_13_429885	387	7	p	p	NN
10_1101-2021_02_13_429885	387	8	n	n	NN
10_1101-2021_02_13_429885	387	9	,	,	,
10_1101-2021_02_13_429885	387	10	k	k	NNP
10_1101-2021_02_13_429885	387	11	=	=	SYM
10_1101-2021_02_13_429885	387	12	c	c	NNP
10_1101-2021_02_13_429885	387	13	π	π	NN
10_1101-2021_02_13_429885	387	14	From	from	IN
10_1101-2021_02_13_429885	387	15	this	this	DT
10_1101-2021_02_13_429885	387	16	information	information	NN
10_1101-2021_02_13_429885	387	17	we	-PRON-	PRP
10_1101-2021_02_13_429885	387	18	obtain	obtain	VBP
10_1101-2021_02_13_429885	387	19	the	the	DT
10_1101-2021_02_13_429885	387	20	entropy	entropy	JJ
10_1101-2021_02_13_429885	387	21	of	of	IN
10_1101-2021_02_13_429885	387	22	,	,	,
10_1101-2021_02_13_429885	387	23	which	which	WDT
10_1101-2021_02_13_429885	387	24	is	be	VBZ
10_1101-2021_02_13_429885	387	25	low	low	JJ
10_1101-2021_02_13_429885	387	26	for	for	IN
10_1101-2021_02_13_429885	387	27	values	value	NNS
10_1101-2021_02_13_429885	387	28	that	that	WDT
10_1101-2021_02_13_429885	387	29	are	be	VBP
10_1101-2021_02_13_429885	387	30	(	(	-LRB-
10_1101-2021_02_13_429885	387	31	z)H	z)H	NNP
10_1101-2021_02_13_429885	387	32	z	z	NN
10_1101-2021_02_13_429885	387	33	assignable	assignable	JJ
10_1101-2021_02_13_429885	387	34	to	to	IN
10_1101-2021_02_13_429885	387	35	only	only	RB
10_1101-2021_02_13_429885	387	36	one	one	CD
10_1101-2021_02_13_429885	387	37	cluster	cluster	NN
10_1101-2021_02_13_429885	387	38	.	.	.
10_1101-2021_02_13_429885	388	1	Recall	recall	NN
10_1101-2021_02_13_429885	388	2	in	in	IN
10_1101-2021_02_13_429885	388	3	this	this	DT
10_1101-2021_02_13_429885	388	4	respect	respect	NN
10_1101-2021_02_13_429885	388	5	that	that	IN
10_1101-2021_02_13_429885	388	6	the	the	DT
10_1101-2021_02_13_429885	388	7	maximum	maximum	JJ
10_1101-2021_02_13_429885	388	8	entropy	entropy	JJ
10_1101-2021_02_13_429885	388	9	distribution	distribution	NN
10_1101-2021_02_13_429885	388	10	is	be	VBZ
10_1101-2021_02_13_429885	388	11	the	the	DT
10_1101-2021_02_13_429885	388	12	uniform	uniform	JJ
10_1101-2021_02_13_429885	388	13	one	one	CD
10_1101-2021_02_13_429885	388	14	,	,	,
10_1101-2021_02_13_429885	388	15	which	which	WDT
10_1101-2021_02_13_429885	388	16	is	be	VBZ
10_1101-2021_02_13_429885	388	17	when	when	WRB
10_1101-2021_02_13_429885	388	18	a	a	DT
10_1101-2021_02_13_429885	388	19	mutation	mutation	NN
10_1101-2021_02_13_429885	388	20	can	can	MD
10_1101-2021_02_13_429885	388	21	be	be	VB
10_1101-2021_02_13_429885	388	22	equally	equally	RB
10_1101-2021_02_13_429885	388	23	likely	likely	JJ
10_1101-2021_02_13_429885	388	24	in	in	IN
10_1101-2021_02_13_429885	388	25	1	1	CD
10_1101-2021_02_13_429885	388	26	or	or	CC
10_1101-2021_02_13_429885	388	27	2	2	CD
10_1101-2021_02_13_429885	388	28	copies	copy	NNS
10_1101-2021_02_13_429885	388	29	,	,	,
10_1101-2021_02_13_429885	388	30	based	base	VBN
10_1101-2021_02_13_429885	388	31	on	on	IN
10_1101-2021_02_13_429885	388	32	VAF	VAF	NNP
10_1101-2021_02_13_429885	388	33	.	.	.
10_1101-2021_02_13_429885	389	1	We	-PRON-	PRP
10_1101-2021_02_13_429885	389	2	use	use	VBP
10_1101-2021_02_13_429885	389	3	a	a	DT
10_1101-2021_02_13_429885	389	4	simple	simple	JJ
10_1101-2021_02_13_429885	389	5	peak	peak	NN
10_1101-2021_02_13_429885	389	6	detection	detection	NN
10_1101-2021_02_13_429885	389	7	heuristic	heuristic	JJ
10_1101-2021_02_13_429885	389	8	to	to	TO
10_1101-2021_02_13_429885	389	9	find	find	VB
10_1101-2021_02_13_429885	389	10	2	2	CD
10_1101-2021_02_13_429885	389	11	points	point	NNS
10_1101-2021_02_13_429885	389	12	of	of	IN
10_1101-2021_02_13_429885	389	13	changes	change	NNS
10_1101-2021_02_13_429885	389	14	in	in	IN
10_1101-2021_02_13_429885	389	15	;	;	:
10_1101-2021_02_13_429885	389	16	in	in	IN
10_1101-2021_02_13_429885	389	17	(	(	-LRB-
10_1101-2021_02_13_429885	389	18	z)H	z)H	NNS
10_1101-2021_02_13_429885	389	19	between	between	IN
10_1101-2021_02_13_429885	389	20	those	those	DT
10_1101-2021_02_13_429885	389	21	values	value	NNS
10_1101-2021_02_13_429885	389	22	we	-PRON-	PRP
10_1101-2021_02_13_429885	389	23	can	can	MD
10_1101-2021_02_13_429885	389	24	not	not	RB
10_1101-2021_02_13_429885	389	25	reliably	reliably	RB
10_1101-2021_02_13_429885	389	26	assess	assess	VB
10_1101-2021_02_13_429885	389	27	,	,	,
10_1101-2021_02_13_429885	389	28	i.e.	i.e.	FW
10_1101-2021_02_13_429885	390	1	assess	assess	VB
10_1101-2021_02_13_429885	390	2	if	if	IN
10_1101-2021_02_13_429885	390	3	the	the	DT
10_1101-2021_02_13_429885	390	4	mutation	mutation	NN
10_1101-2021_02_13_429885	390	5	is	be	VBZ
10_1101-2021_02_13_429885	390	6	in	in	IN
10_1101-2021_02_13_429885	390	7	m	m	NNP
10_1101-2021_02_13_429885	390	8	single	single	JJ
10_1101-2021_02_13_429885	390	9	or	or	CC
10_1101-2021_02_13_429885	390	10	double	double	JJ
10_1101-2021_02_13_429885	390	11	copy	copy	NN
10_1101-2021_02_13_429885	390	12	.	.	.
10_1101-2021_02_13_429885	391	1	For	for	IN
10_1101-2021_02_13_429885	391	2	these	these	DT
10_1101-2021_02_13_429885	391	3	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	391	4	leaves	leave	VBZ
10_1101-2021_02_13_429885	391	5	the	the	DT
10_1101-2021_02_13_429885	391	6	CCF	CCF	NNP
10_1101-2021_02_13_429885	391	7	value	value	NN
10_1101-2021_02_13_429885	391	8	as	as	IN
10_1101-2021_02_13_429885	391	9	NA	NA	NNP
10_1101-2021_02_13_429885	391	10	.	.	.
10_1101-2021_02_13_429885	392	1	The	the	DT
10_1101-2021_02_13_429885	392	2	alternative	alternative	JJ
10_1101-2021_02_13_429885	392	3	approach	approach	NN
10_1101-2021_02_13_429885	392	4	uses	use	VBZ
10_1101-2021_02_13_429885	392	5	a	a	DT
10_1101-2021_02_13_429885	392	6	simpler	simple	JJR
10_1101-2021_02_13_429885	392	7	idea	idea	NN
10_1101-2021_02_13_429885	392	8	,	,	,
10_1101-2021_02_13_429885	392	9	still	still	RB
10_1101-2021_02_13_429885	392	10	working	work	VBG
10_1101-2021_02_13_429885	392	11	on	on	IN
10_1101-2021_02_13_429885	392	12	the	the	DT
10_1101-2021_02_13_429885	392	13	expected	expect	VBN
10_1101-2021_02_13_429885	392	14	theoretical	theoretical	JJ
10_1101-2021_02_13_429885	392	15	VAF	VAF	NNP
10_1101-2021_02_13_429885	392	16	.	.	.
10_1101-2021_02_13_429885	393	1	Here	here	RB
10_1101-2021_02_13_429885	393	2	instead	instead	RB
10_1101-2021_02_13_429885	393	3	of	of	IN
10_1101-2021_02_13_429885	393	4	fitting	fit	VBG
10_1101-2021_02_13_429885	393	5	a	a	DT
10_1101-2021_02_13_429885	393	6	mixture	mixture	NN
10_1101-2021_02_13_429885	393	7	we	-PRON-	PRP
10_1101-2021_02_13_429885	393	8	determine	determine	VBP
10_1101-2021_02_13_429885	393	9	the	the	DT
10_1101-2021_02_13_429885	393	10	midpoint	midpoint	NN
10_1101-2021_02_13_429885	393	11	,	,	,
10_1101-2021_02_13_429885	393	12	between	between	IN
10_1101-2021_02_13_429885	393	13	the	the	DT
10_1101-2021_02_13_429885	393	14	two	two	CD
10_1101-2021_02_13_429885	393	15	o	o	XX
10_1101-2021_02_13_429885	393	16	expected	expect	VBN
10_1101-2021_02_13_429885	393	17	theoretical	theoretical	JJ
10_1101-2021_02_13_429885	393	18	VAF	VAF	NNP
10_1101-2021_02_13_429885	393	19	peaks	peak	NNS
10_1101-2021_02_13_429885	393	20	.	.	.
10_1101-2021_02_13_429885	394	1	The	the	DT
10_1101-2021_02_13_429885	394	2	midpoint	midpoint	NN
10_1101-2021_02_13_429885	394	3	is	be	VBZ
10_1101-2021_02_13_429885	394	4	computed	compute	VBN
10_1101-2021_02_13_429885	394	5	by	by	IN
10_1101-2021_02_13_429885	394	6	weighting	weight	VBG
10_1101-2021_02_13_429885	394	7	each	each	DT
10_1101-2021_02_13_429885	394	8	of	of	IN
10_1101-2021_02_13_429885	394	9	the	the	DT
10_1101-2021_02_13_429885	394	10	two	two	CD
10_1101-2021_02_13_429885	394	11	peaks	peak	NNS
10_1101-2021_02_13_429885	394	12	proportionally	proportionally	RB
10_1101-2021_02_13_429885	394	13	to	to	IN
10_1101-2021_02_13_429885	394	14	the	the	DT
10_1101-2021_02_13_429885	394	15	number	number	NN
10_1101-2021_02_13_429885	394	16	of	of	IN
10_1101-2021_02_13_429885	394	17	mutations	mutation	NNS
10_1101-2021_02_13_429885	394	18	that	that	WDT
10_1101-2021_02_13_429885	394	19	appear	appear	VBP
10_1101-2021_02_13_429885	394	20	underneath	underneath	IN
10_1101-2021_02_13_429885	394	21	each	each	DT
10_1101-2021_02_13_429885	394	22	peak	peak	NN
10_1101-2021_02_13_429885	394	23	.	.	.
10_1101-2021_02_13_429885	395	1	The	the	DT
10_1101-2021_02_13_429885	395	2	midpoint	midpoint	NN
10_1101-2021_02_13_429885	395	3	is	be	VBZ
10_1101-2021_02_13_429885	395	4	a	a	DT
10_1101-2021_02_13_429885	395	5	cut	cut	NN
10_1101-2021_02_13_429885	395	6	:	:	:
10_1101-2021_02_13_429885	395	7	values	value	NNS
10_1101-2021_02_13_429885	395	8	below	below	RB
10_1101-2021_02_13_429885	395	9	are	be	VBP
10_1101-2021_02_13_429885	395	10	in	in	IN
10_1101-2021_02_13_429885	395	11	single	single	JJ
10_1101-2021_02_13_429885	395	12	copy	copy	NN
10_1101-2021_02_13_429885	395	13	,	,	,
10_1101-2021_02_13_429885	395	14	values	value	NNS
10_1101-2021_02_13_429885	395	15	above	above	RB
10_1101-2021_02_13_429885	395	16	in	in	IN
10_1101-2021_02_13_429885	395	17	two	two	CD
10_1101-2021_02_13_429885	395	18	.	.	.
10_1101-2021_02_13_429885	396	1	This	this	DT
10_1101-2021_02_13_429885	396	2	o	o	NN
10_1101-2021_02_13_429885	396	3	procedure	procedure	NN
10_1101-2021_02_13_429885	396	4	requires	require	VBZ
10_1101-2021_02_13_429885	396	5	data	datum	NNS
10_1101-2021_02_13_429885	396	6	with	with	IN
10_1101-2021_02_13_429885	396	7	good	good	JJ
10_1101-2021_02_13_429885	396	8	sequencing	sequencing	NN
10_1101-2021_02_13_429885	396	9	coverage	coverage	NN
10_1101-2021_02_13_429885	396	10	,	,	,
10_1101-2021_02_13_429885	396	11	and	and	CC
10_1101-2021_02_13_429885	396	12	a	a	DT
10_1101-2021_02_13_429885	396	13	good	good	JJ
10_1101-2021_02_13_429885	396	14	general	general	JJ
10_1101-2021_02_13_429885	396	15	quality	quality	NN
10_1101-2021_02_13_429885	396	16	.	.	.
10_1101-2021_02_13_429885	397	1	When	when	WRB
10_1101-2021_02_13_429885	397	2	mutation	mutation	NN
10_1101-2021_02_13_429885	397	3	multiplicities	multiplicity	NNS
10_1101-2021_02_13_429885	397	4	have	have	VBP
10_1101-2021_02_13_429885	397	5	been	be	VBN
10_1101-2021_02_13_429885	397	6	determined	determine	VBN
10_1101-2021_02_13_429885	397	7	,	,	,
10_1101-2021_02_13_429885	397	8	CCF	CCF	NNP
10_1101-2021_02_13_429885	397	9	computation	computation	NN
10_1101-2021_02_13_429885	397	10	is	be	VBZ
10_1101-2021_02_13_429885	397	11	trivial	trivial	JJ
10_1101-2021_02_13_429885	397	12	,	,	,
10_1101-2021_02_13_429885	397	13	and	and	CC
10_1101-2021_02_13_429885	397	14	follows	follow	VBZ
10_1101-2021_02_13_429885	397	15	the	the	DT
10_1101-2021_02_13_429885	397	16	formula	formula	NN
10_1101-2021_02_13_429885	397	17	presented	present	VBN
10_1101-2021_02_13_429885	397	18	in	in	IN
10_1101-2021_02_13_429885	397	19	the	the	DT
10_1101-2021_02_13_429885	397	20	Main	Main	NNP
10_1101-2021_02_13_429885	397	21	Text	Text	NNP
10_1101-2021_02_13_429885	397	22	.	.	.
10_1101-2021_02_13_429885	398	1	A	a	DT
10_1101-2021_02_13_429885	398	2	QC	qc	NN
10_1101-2021_02_13_429885	398	3	PASS	PASS	NNP
10_1101-2021_02_13_429885	398	4	status	status	NN
10_1101-2021_02_13_429885	398	5	is	be	VBZ
10_1101-2021_02_13_429885	398	6	assigned	assign	VBN
10_1101-2021_02_13_429885	398	7	to	to	IN
10_1101-2021_02_13_429885	398	8	the	the	DT
10_1101-2021_02_13_429885	398	9	.CC	.CC	:
10_1101-2021_02_13_429885	398	10	-	-	HYPH
10_1101-2021_02_13_429885	398	11	BY	by	IN
10_1101-2021_02_13_429885	398	12	-	-	HYPH
10_1101-2021_02_13_429885	398	13	NC	NC	NNP
10_1101-2021_02_13_429885	398	14	-	-	HYPH
10_1101-2021_02_13_429885	398	15	ND	ND	NNP
10_1101-2021_02_13_429885	398	16	4.0	4.0	CD
10_1101-2021_02_13_429885	398	17	International	International	NNP
10_1101-2021_02_13_429885	398	18	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	398	19	under	under	IN
10_1101-2021_02_13_429885	398	20	a	a	DT
10_1101-2021_02_13_429885	398	21	(	(	-LRB-
10_1101-2021_02_13_429885	398	22	which	which	WDT
10_1101-2021_02_13_429885	398	23	was	be	VBD
10_1101-2021_02_13_429885	398	24	not	not	RB
10_1101-2021_02_13_429885	398	25	certified	certify	VBN
10_1101-2021_02_13_429885	398	26	by	by	IN
10_1101-2021_02_13_429885	398	27	peer	peer	NN
10_1101-2021_02_13_429885	398	28	review	review	NN
10_1101-2021_02_13_429885	398	29	)	)	-RRB-
10_1101-2021_02_13_429885	398	30	is	be	VBZ
10_1101-2021_02_13_429885	398	31	the	the	DT
10_1101-2021_02_13_429885	398	32	author	author	NN
10_1101-2021_02_13_429885	398	33	/	/	SYM
10_1101-2021_02_13_429885	398	34	funder	funder	NN
10_1101-2021_02_13_429885	398	35	,	,	,
10_1101-2021_02_13_429885	398	36	who	who	WP
10_1101-2021_02_13_429885	398	37	has	have	VBZ
10_1101-2021_02_13_429885	398	38	granted	grant	VBN
10_1101-2021_02_13_429885	398	39	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	398	40	a	a	DT
10_1101-2021_02_13_429885	398	41	license	license	NN
10_1101-2021_02_13_429885	398	42	to	to	TO
10_1101-2021_02_13_429885	398	43	display	display	VB
10_1101-2021_02_13_429885	398	44	the	the	DT
10_1101-2021_02_13_429885	398	45	preprint	preprint	NN
10_1101-2021_02_13_429885	398	46	in	in	IN
10_1101-2021_02_13_429885	398	47	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	398	48	.	.	.
10_1101-2021_02_13_429885	399	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	399	2	is	be	VBZ
10_1101-2021_02_13_429885	399	3	made	make	VBN
10_1101-2021_02_13_429885	399	4	The	the	DT
10_1101-2021_02_13_429885	399	5	copyright	copyright	NN
10_1101-2021_02_13_429885	399	6	holder	holder	NN
10_1101-2021_02_13_429885	399	7	for	for	IN
10_1101-2021_02_13_429885	399	8	this	this	DT
10_1101-2021_02_13_429885	399	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	399	10	version	version	NN
10_1101-2021_02_13_429885	399	11	posted	post	VBD
10_1101-2021_02_13_429885	399	12	February	February	NNP
10_1101-2021_02_13_429885	399	13	13	13	CD
10_1101-2021_02_13_429885	399	14	,	,	,
10_1101-2021_02_13_429885	399	15	2021	2021	CD
10_1101-2021_02_13_429885	399	16	.	.	.
10_1101-2021_02_13_429885	399	17	;	;	:
10_1101-2021_02_13_429885	399	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	399	19	:	:	:
10_1101-2021_02_13_429885	399	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	399	21	preprint	preprint	NN
10_1101-2021_02_13_429885	399	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	399	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	399	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	399	25	et	et	FW
10_1101-2021_02_13_429885	399	26	al	al	NNP
10_1101-2021_02_13_429885	399	27	.	.	.
10_1101-2021_02_13_429885	400	1	A	a	DT
10_1101-2021_02_13_429885	400	2	fully	fully	RB
10_1101-2021_02_13_429885	400	3	automated	automate	VBN
10_1101-2021_02_13_429885	400	4	approach	approach	NN
10_1101-2021_02_13_429885	400	5	for	for	IN
10_1101-2021_02_13_429885	400	6	quality	quality	NN
10_1101-2021_02_13_429885	400	7	control	control	NN
10_1101-2021_02_13_429885	400	8	of	of	IN
10_1101-2021_02_13_429885	400	9	cancer	cancer	NN
10_1101-2021_02_13_429885	400	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	400	11	in	in	IN
10_1101-2021_02_13_429885	400	12	the	the	DT
10_1101-2021_02_13_429885	400	13	era	era	NN
10_1101-2021_02_13_429885	400	14	of	of	IN
10_1101-2021_02_13_429885	400	15	high	high	JJ
10_1101-2021_02_13_429885	400	16	-	-	HYPH
10_1101-2021_02_13_429885	400	17	resolution	resolution	NN
10_1101-2021_02_13_429885	400	18	whole	whole	JJ
10_1101-2021_02_13_429885	400	19	genome	genome	JJ
10_1101-2021_02_13_429885	400	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	400	21	.	.	.
10_1101-2021_02_13_429885	401	1	CCF	ccf	NN
10_1101-2021_02_13_429885	401	2	values	value	NNS
10_1101-2021_02_13_429885	401	3	for	for	IN
10_1101-2021_02_13_429885	401	4	a	a	DT
10_1101-2021_02_13_429885	401	5	copy	copy	NN
10_1101-2021_02_13_429885	401	6	state	state	NN
10_1101-2021_02_13_429885	401	7	,	,	,
10_1101-2021_02_13_429885	401	8	if	if	IN
10_1101-2021_02_13_429885	401	9	less	less	JJR
10_1101-2021_02_13_429885	401	10	than	than	IN
10_1101-2021_02_13_429885	401	11	10	10	CD
10_1101-2021_02_13_429885	401	12	%	%	NN
10_1101-2021_02_13_429885	401	13	(	(	-LRB-
10_1101-2021_02_13_429885	401	14	or	or	CC
10_1101-2021_02_13_429885	401	15	any	any	DT
10_1101-2021_02_13_429885	401	16	custom	custom	NN
10_1101-2021_02_13_429885	401	17	threshold	threshold	NN
10_1101-2021_02_13_429885	401	18	)	)	-RRB-
10_1101-2021_02_13_429885	401	19	are	be	VBP
10_1101-2021_02_13_429885	401	20	unassigned	unassigned	JJ
10_1101-2021_02_13_429885	401	21	.	.	.
10_1101-2021_02_13_429885	402	1	The	the	DT
10_1101-2021_02_13_429885	402	2	overall	overall	JJ
10_1101-2021_02_13_429885	402	3	sample	sample	NN
10_1101-2021_02_13_429885	402	4	is	be	VBZ
10_1101-2021_02_13_429885	402	5	given	give	VBN
10_1101-2021_02_13_429885	402	6	a	a	DT
10_1101-2021_02_13_429885	402	7	QC	QC	NNP
10_1101-2021_02_13_429885	402	8	status	status	NN
10_1101-2021_02_13_429885	402	9	based	base	VBN
10_1101-2021_02_13_429885	402	10	on	on	IN
10_1101-2021_02_13_429885	402	11	a	a	DT
10_1101-2021_02_13_429885	402	12	majority	majority	NN
10_1101-2021_02_13_429885	402	13	policy	policy	NN
10_1101-2021_02_13_429885	402	14	.	.	.
10_1101-2021_02_13_429885	403	1	Genome	genome	JJ
10_1101-2021_02_13_429885	403	2	fragmentation	fragmentation	NN
10_1101-2021_02_13_429885	403	3	Some	some	DT
10_1101-2021_02_13_429885	403	4	recently	recently	RB
10_1101-2021_02_13_429885	403	5	identified	identify	VBN
10_1101-2021_02_13_429885	403	6	patterns	pattern	NNS
10_1101-2021_02_13_429885	403	7	of	of	IN
10_1101-2021_02_13_429885	403	8	somatic	somatic	JJ
10_1101-2021_02_13_429885	403	9	CNA	cna	NN
10_1101-2021_02_13_429885	403	10	changes	change	NNS
10_1101-2021_02_13_429885	403	11	can	can	MD
10_1101-2021_02_13_429885	403	12	be	be	VB
10_1101-2021_02_13_429885	403	13	attributed	attribute	VBN
10_1101-2021_02_13_429885	403	14	to	to	IN
10_1101-2021_02_13_429885	403	15	the	the	DT
10_1101-2021_02_13_429885	403	16	presence	presence	NN
10_1101-2021_02_13_429885	403	17	of	of	IN
10_1101-2021_02_13_429885	403	18	highly	highly	RB
10_1101-2021_02_13_429885	403	19	fragmented	fragmented	JJ
10_1101-2021_02_13_429885	403	20	tumour	tumour	NN
10_1101-2021_02_13_429885	403	21	genomes	genome	NNS
10_1101-2021_02_13_429885	403	22	,	,	,
10_1101-2021_02_13_429885	403	23	termed	term	VBD
10_1101-2021_02_13_429885	403	24	chromothripsis	chromothripsis	NN
10_1101-2021_02_13_429885	403	25	and	and	CC
10_1101-2021_02_13_429885	403	26	chromoplexy	chromoplexy	NN
10_1101-2021_02_13_429885	403	27	,	,	,
10_1101-2021_02_13_429885	403	28	or	or	CC
10_1101-2021_02_13_429885	403	29	localised	localise	VBN
10_1101-2021_02_13_429885	403	30	hypermutation	hypermutation	NN
10_1101-2021_02_13_429885	403	31	patterns	pattern	NNS
10_1101-2021_02_13_429885	403	32	,	,	,
10_1101-2021_02_13_429885	403	33	termed	term	VBD
10_1101-2021_02_13_429885	403	34	kataegis	kataegis	NNP
10_1101-2021_02_13_429885	403	35	​(Cortés	​(Cortés	NNPS
10_1101-2021_02_13_429885	403	36	-	-	HYPH
10_1101-2021_02_13_429885	403	37	Ciriano	Ciriano	NNP
10_1101-2021_02_13_429885	403	38	et	et	NNP
10_1101-2021_02_13_429885	403	39	al	al	NNP
10_1101-2021_02_13_429885	403	40	.	.	.
10_1101-2021_02_13_429885	404	1	2020)​.	2020)​.	CD
10_1101-2021_02_13_429885	405	1	While	while	IN
10_1101-2021_02_13_429885	405	2	these	these	DT
10_1101-2021_02_13_429885	405	3	can	can	MD
10_1101-2021_02_13_429885	405	4	be	be	VB
10_1101-2021_02_13_429885	405	5	identified	identify	VBN
10_1101-2021_02_13_429885	405	6	using	use	VBG
10_1101-2021_02_13_429885	405	7	dedicated	dedicated	JJ
10_1101-2021_02_13_429885	405	8	bioinformatics	bioinformatic	NNS
10_1101-2021_02_13_429885	405	9	tools	tool	NNS
10_1101-2021_02_13_429885	405	10	,	,	,
10_1101-2021_02_13_429885	405	11	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	405	12	offers	offer	VBZ
10_1101-2021_02_13_429885	405	13	a	a	DT
10_1101-2021_02_13_429885	405	14	simple	simple	JJ
10_1101-2021_02_13_429885	405	15	statistical	statistical	JJ
10_1101-2021_02_13_429885	405	16	test	test	NN
10_1101-2021_02_13_429885	405	17	to	to	TO
10_1101-2021_02_13_429885	405	18	detect	detect	VB
10_1101-2021_02_13_429885	405	19	the	the	DT
10_1101-2021_02_13_429885	405	20	presence	presence	NN
10_1101-2021_02_13_429885	405	21	of	of	IN
10_1101-2021_02_13_429885	405	22	over	over	IN
10_1101-2021_02_13_429885	405	23	-	-	HYPH
10_1101-2021_02_13_429885	405	24	fragmentation	fragmentation	NN
10_1101-2021_02_13_429885	405	25	in	in	IN
10_1101-2021_02_13_429885	405	26	a	a	DT
10_1101-2021_02_13_429885	405	27	chromosome	chromosome	NN
10_1101-2021_02_13_429885	405	28	arm	arm	NN
10_1101-2021_02_13_429885	405	29	,	,	,
10_1101-2021_02_13_429885	405	30	a	a	DT
10_1101-2021_02_13_429885	405	31	prerequisite	prerequisite	NN
10_1101-2021_02_13_429885	405	32	that	that	WDT
10_1101-2021_02_13_429885	405	33	could	could	MD
10_1101-2021_02_13_429885	405	34	point	point	VB
10_1101-2021_02_13_429885	405	35	to	to	IN
10_1101-2021_02_13_429885	405	36	the	the	DT
10_1101-2021_02_13_429885	405	37	presence	presence	NN
10_1101-2021_02_13_429885	405	38	of	of	IN
10_1101-2021_02_13_429885	405	39	such	such	JJ
10_1101-2021_02_13_429885	405	40	patterns	pattern	NNS
10_1101-2021_02_13_429885	405	41	.	.	.
10_1101-2021_02_13_429885	406	1	The	the	DT
10_1101-2021_02_13_429885	406	2	test	test	NN
10_1101-2021_02_13_429885	406	3	works	work	VBZ
10_1101-2021_02_13_429885	406	4	at	at	IN
10_1101-2021_02_13_429885	406	5	the	the	DT
10_1101-2021_02_13_429885	406	6	level	level	NN
10_1101-2021_02_13_429885	406	7	of	of	IN
10_1101-2021_02_13_429885	406	8	each	each	DT
10_1101-2021_02_13_429885	406	9	chromosome	chromosome	NN
10_1101-2021_02_13_429885	406	10	arm	arm	NN
10_1101-2021_02_13_429885	406	11	(	(	-LRB-
10_1101-2021_02_13_429885	406	12	1p	1p	NNP
10_1101-2021_02_13_429885	406	13	,	,	,
10_1101-2021_02_13_429885	406	14	1q	1q	CD
10_1101-2021_02_13_429885	406	15	,	,	,
10_1101-2021_02_13_429885	406	16	2p	2p	NNP
10_1101-2021_02_13_429885	406	17	,	,	,
10_1101-2021_02_13_429885	406	18	2q	2q	CD
10_1101-2021_02_13_429885	406	19	,	,	,
10_1101-2021_02_13_429885	406	20	etc	etc	FW
10_1101-2021_02_13_429885	406	21	.	.	.
10_1101-2021_02_13_429885	407	1	)	)	-RRB-
10_1101-2021_02_13_429885	407	2	,	,	,
10_1101-2021_02_13_429885	407	3	and	and	CC
10_1101-2021_02_13_429885	407	4	uses	use	VBZ
10_1101-2021_02_13_429885	407	5	the	the	DT
10_1101-2021_02_13_429885	407	6	length	length	NN
10_1101-2021_02_13_429885	407	7	of	of	IN
10_1101-2021_02_13_429885	407	8	each	each	DT
10_1101-2021_02_13_429885	407	9	input	input	NN
10_1101-2021_02_13_429885	407	10	CNA	CNA	NNP
10_1101-2021_02_13_429885	407	11	segment	segment	NN
10_1101-2021_02_13_429885	407	12	to	to	TO
10_1101-2021_02_13_429885	407	13	assign	assign	VB
10_1101-2021_02_13_429885	407	14	a	a	DT
10_1101-2021_02_13_429885	407	15	“	"	``
10_1101-2021_02_13_429885	407	16	long	long	JJ
10_1101-2021_02_13_429885	407	17	segment	segment	NN
10_1101-2021_02_13_429885	407	18	”	"	''
10_1101-2021_02_13_429885	407	19	or	or	CC
10_1101-2021_02_13_429885	407	20	“	"	``
10_1101-2021_02_13_429885	407	21	short	short	JJ
10_1101-2021_02_13_429885	407	22	segment	segment	NN
10_1101-2021_02_13_429885	407	23	”	"	''
10_1101-2021_02_13_429885	407	24	status	status	NN
10_1101-2021_02_13_429885	407	25	.	.	.
10_1101-2021_02_13_429885	408	1	This	this	DT
10_1101-2021_02_13_429885	408	2	is	be	VBZ
10_1101-2021_02_13_429885	408	3	determined	determine	VBN
10_1101-2021_02_13_429885	408	4	by	by	IN
10_1101-2021_02_13_429885	408	5	a	a	DT
10_1101-2021_02_13_429885	408	6	cut	cut	NN
10_1101-2021_02_13_429885	408	7	parameter	parameter	NN
10_1101-2021_02_13_429885	408	8	that	that	WDT
10_1101-2021_02_13_429885	408	9	is	be	VBZ
10_1101-2021_02_13_429885	408	10	set	set	VBN
10_1101-2021_02_13_429885	408	11	,	,	,
10_1101-2021_02_13_429885	408	12	by	by	IN
10_1101-2021_02_13_429885	408	13	default	default	NN
10_1101-2021_02_13_429885	408	14	,	,	,
10_1101-2021_02_13_429885	408	15	to	to	IN
10_1101-2021_02_13_429885	408	16	20	20	CD
10_1101-2021_02_13_429885	408	17	%	%	NN
10_1101-2021_02_13_429885	408	18	(	(	-LRB-
10_1101-2021_02_13_429885	408	19	i.e.	i.e.	FW
10_1101-2021_02_13_429885	408	20	,	,	,
10_1101-2021_02_13_429885	408	21	)	)	-RRB-
10_1101-2021_02_13_429885	408	22	.	.	.
10_1101-2021_02_13_429885	409	1	μ	μ	LS
10_1101-2021_02_13_429885	409	2	.2μ	.2μ	NFP
10_1101-2021_02_13_429885	409	3	=	=	NFP
10_1101-2021_02_13_429885	409	4	0	0	NFP
10_1101-2021_02_13_429885	409	5	Then	then	RB
10_1101-2021_02_13_429885	409	6	,	,	,
10_1101-2021_02_13_429885	409	7	a	a	DT
10_1101-2021_02_13_429885	409	8	null	null	NN
10_1101-2021_02_13_429885	409	9	hypothesis	hypothesis	NN
10_1101-2021_02_13_429885	409	10	is	be	VBZ
10_1101-2021_02_13_429885	409	11	used	use	VBN
10_1101-2021_02_13_429885	409	12	to	to	TO
10_1101-2021_02_13_429885	409	13	compute	compute	VB
10_1101-2021_02_13_429885	409	14	a	a	DT
10_1101-2021_02_13_429885	409	15	p	p	NN
10_1101-2021_02_13_429885	409	16	-	-	HYPH
10_1101-2021_02_13_429885	409	17	value	value	NN
10_1101-2021_02_13_429885	409	18	.	.	.
10_1101-2021_02_13_429885	410	1	That	that	DT
10_1101-2021_02_13_429885	410	2	is	be	VBZ
10_1101-2021_02_13_429885	410	3	defined	define	VBN
10_1101-2021_02_13_429885	410	4	using	use	VBG
10_1101-2021_02_13_429885	410	5	a	a	DT
10_1101-2021_02_13_429885	410	6	Binomial	Binomial	NNP
10_1101-2021_02_13_429885	410	7	test	test	NN
10_1101-2021_02_13_429885	410	8	based	base	VBN
10_1101-2021_02_13_429885	410	9	on	on	IN
10_1101-2021_02_13_429885	410	10	,	,	,
10_1101-2021_02_13_429885	410	11	the	the	DT
10_1101-2021_02_13_429885	410	12	number	number	NN
10_1101-2021_02_13_429885	410	13	of	of	IN
10_1101-2021_02_13_429885	410	14	trials	trial	NNS
10_1101-2021_02_13_429885	410	15	given	give	VBN
10_1101-2021_02_13_429885	410	16	by	by	IN
10_1101-2021_02_13_429885	410	17	the	the	DT
10_1101-2021_02_13_429885	410	18	total	total	JJ
10_1101-2021_02_13_429885	410	19	segment	segment	NN
10_1101-2021_02_13_429885	410	20	counts	count	NNS
10_1101-2021_02_13_429885	410	21	in	in	IN
10_1101-2021_02_13_429885	410	22	the	the	DT
10_1101-2021_02_13_429885	410	23	arm	arm	NN
10_1101-2021_02_13_429885	410	24	,	,	,
10_1101-2021_02_13_429885	410	25	and	and	CC
10_1101-2021_02_13_429885	410	26	k	k	NNP
10_1101-2021_02_13_429885	410	27	the	the	DT
10_1101-2021_02_13_429885	410	28	observed	observed	JJ
10_1101-2021_02_13_429885	410	29	number	number	NN
10_1101-2021_02_13_429885	410	30	of	of	IN
10_1101-2021_02_13_429885	410	31	short	short	JJ
10_1101-2021_02_13_429885	410	32	segments	segment	NNS
10_1101-2021_02_13_429885	410	33	.	.	.
10_1101-2021_02_13_429885	411	1	The	the	DT
10_1101-2021_02_13_429885	411	2	Binomial	Binomial	NNP
10_1101-2021_02_13_429885	411	3	distribution	distribution	NN
10_1101-2021_02_13_429885	411	4	for	for	IN
10_1101-2021_02_13_429885	411	5	is	be	VBZ
10_1101-2021_02_13_429885	411	6	defined	define	VBN
10_1101-2021_02_13_429885	411	7	s	s	POS
10_1101-2021_02_13_429885	411	8	H0	h0	NN
10_1101-2021_02_13_429885	411	9	by	by	IN
10_1101-2021_02_13_429885	411	10	,	,	,
10_1101-2021_02_13_429885	411	11	and	and	CC
10_1101-2021_02_13_429885	411	12	the	the	DT
10_1101-2021_02_13_429885	411	13	null	null	NN
10_1101-2021_02_13_429885	411	14	is	be	VBZ
10_1101-2021_02_13_429885	411	15	the	the	DT
10_1101-2021_02_13_429885	411	16	probability	probability	NN
10_1101-2021_02_13_429885	411	17	of	of	IN
10_1101-2021_02_13_429885	411	18	observing	observe	VBG
10_1101-2021_02_13_429885	411	19	at	at	IN
10_1101-2021_02_13_429885	411	20	least	least	JJS
10_1101-2021_02_13_429885	411	21	short	short	JJ
10_1101-2021_02_13_429885	411	22	segments	segment	NNS
10_1101-2021_02_13_429885	411	23	,	,	,
10_1101-2021_02_13_429885	411	24	a	a	DT
10_1101-2021_02_13_429885	411	25	one	one	CD
10_1101-2021_02_13_429885	411	26	-	-	HYPH
10_1101-2021_02_13_429885	411	27	tailed	tail	VBN
10_1101-2021_02_13_429885	411	28	μ	μ	NNP
10_1101-2021_02_13_429885	411	29	s	s	NNP
10_1101-2021_02_13_429885	411	30	test	test	NN
10_1101-2021_02_13_429885	411	31	for	for	IN
10_1101-2021_02_13_429885	411	32	whether	whether	IN
10_1101-2021_02_13_429885	411	33	the	the	DT
10_1101-2021_02_13_429885	411	34	observations	observation	NNS
10_1101-2021_02_13_429885	411	35	are	be	VBP
10_1101-2021_02_13_429885	411	36	biased	biased	JJ
10_1101-2021_02_13_429885	411	37	towards	towards	IN
10_1101-2021_02_13_429885	411	38	shorter	short	JJR
10_1101-2021_02_13_429885	411	39	segments	segment	NNS
10_1101-2021_02_13_429885	411	40	.	.	.
10_1101-2021_02_13_429885	412	1	The	the	DT
10_1101-2021_02_13_429885	412	2	p	p	NN
10_1101-2021_02_13_429885	412	3	-	-	HYPH
10_1101-2021_02_13_429885	412	4	value	value	NN
10_1101-2021_02_13_429885	412	5	is	be	VBZ
10_1101-2021_02_13_429885	412	6	adjusted	adjust	VBN
10_1101-2021_02_13_429885	412	7	for	for	IN
10_1101-2021_02_13_429885	412	8	family	family	NN
10_1101-2021_02_13_429885	412	9	-	-	HYPH
10_1101-2021_02_13_429885	412	10	wise	wise	JJ
10_1101-2021_02_13_429885	412	11	error	error	NN
10_1101-2021_02_13_429885	412	12	rate	rate	NN
10_1101-2021_02_13_429885	412	13	by	by	IN
10_1101-2021_02_13_429885	412	14	Bonferroni	Bonferroni	NNP
10_1101-2021_02_13_429885	412	15	,	,	,
10_1101-2021_02_13_429885	412	16	dividing	divide	VBG
10_1101-2021_02_13_429885	412	17	the	the	DT
10_1101-2021_02_13_429885	412	18	desired	desire	VBN
10_1101-2021_02_13_429885	412	19	-value	-value	NN
10_1101-2021_02_13_429885	412	20	by	by	IN
10_1101-2021_02_13_429885	412	21	the	the	DT
10_1101-2021_02_13_429885	412	22	α	α	NNP
10_1101-2021_02_13_429885	412	23	number	number	NN
10_1101-2021_02_13_429885	412	24	of	of	IN
10_1101-2021_02_13_429885	412	25	tests	test	NNS
10_1101-2021_02_13_429885	412	26	.	.	.
10_1101-2021_02_13_429885	413	1	This	this	DT
10_1101-2021_02_13_429885	413	2	test	test	NN
10_1101-2021_02_13_429885	413	3	is	be	VBZ
10_1101-2021_02_13_429885	413	4	applied	apply	VBN
10_1101-2021_02_13_429885	413	5	to	to	IN
10_1101-2021_02_13_429885	413	6	a	a	DT
10_1101-2021_02_13_429885	413	7	subset	subset	NN
10_1101-2021_02_13_429885	413	8	of	of	IN
10_1101-2021_02_13_429885	413	9	chromosome	chromosome	NN
10_1101-2021_02_13_429885	413	10	arms	arm	NNS
10_1101-2021_02_13_429885	413	11	with	with	IN
10_1101-2021_02_13_429885	413	12	a	a	DT
10_1101-2021_02_13_429885	413	13	minimum	minimum	JJ
10_1101-2021_02_13_429885	413	14	number	number	NN
10_1101-2021_02_13_429885	413	15	of	of	IN
10_1101-2021_02_13_429885	413	16	segments	segment	NNS
10_1101-2021_02_13_429885	413	17	,	,	,
10_1101-2021_02_13_429885	413	18	and	and	CC
10_1101-2021_02_13_429885	413	19	that	that	IN
10_1101-2021_02_13_429885	413	20	“	"	``
10_1101-2021_02_13_429885	413	21	jump	jump	VB
10_1101-2021_02_13_429885	413	22	”	"	''
10_1101-2021_02_13_429885	413	23	in	in	IN
10_1101-2021_02_13_429885	413	24	ploidy	ploidy	NN
10_1101-2021_02_13_429885	413	25	by	by	IN
10_1101-2021_02_13_429885	413	26	a	a	DT
10_1101-2021_02_13_429885	413	27	minimum	minimum	JJ
10_1101-2021_02_13_429885	413	28	amount	amount	NN
10_1101-2021_02_13_429885	413	29	(	(	-LRB-
10_1101-2021_02_13_429885	413	30	empirical	empirical	JJ
10_1101-2021_02_13_429885	413	31	default	default	NN
10_1101-2021_02_13_429885	413	32	values	value	NNS
10_1101-2021_02_13_429885	413	33	estimated	estimate	VBN
10_1101-2021_02_13_429885	413	34	from	from	IN
10_1101-2021_02_13_429885	413	35	trial	trial	NN
10_1101-2021_02_13_429885	413	36	data	datum	NNS
10_1101-2021_02_13_429885	413	37	)	)	-RRB-
10_1101-2021_02_13_429885	413	38	.	.	.
10_1101-2021_02_13_429885	414	1	The	the	DT
10_1101-2021_02_13_429885	414	2	arm	arm	NN
10_1101-2021_02_13_429885	414	3	-	-	HYPH
10_1101-2021_02_13_429885	414	4	level	level	NN
10_1101-2021_02_13_429885	414	5	jump	jump	NN
10_1101-2021_02_13_429885	414	6	is	be	VBZ
10_1101-2021_02_13_429885	414	7	determined	determine	VBN
10_1101-2021_02_13_429885	414	8	as	as	IN
10_1101-2021_02_13_429885	414	9	the	the	DT
10_1101-2021_02_13_429885	414	10	sum	sum	NN
10_1101-2021_02_13_429885	414	11	of	of	IN
10_1101-2021_02_13_429885	414	12	the	the	DT
10_1101-2021_02_13_429885	414	13	difference	difference	NN
10_1101-2021_02_13_429885	414	14	between	between	IN
10_1101-2021_02_13_429885	414	15	the	the	DT
10_1101-2021_02_13_429885	414	16	ploidy	ploidy	NN
10_1101-2021_02_13_429885	414	17	of	of	IN
10_1101-2021_02_13_429885	414	18	two	two	CD
10_1101-2021_02_13_429885	414	19	consecutive	consecutive	JJ
10_1101-2021_02_13_429885	414	20	DNA	dna	NN
10_1101-2021_02_13_429885	414	21	segments	segment	NNS
10_1101-2021_02_13_429885	414	22	.	.	.
10_1101-2021_02_13_429885	415	1	These	these	DT
10_1101-2021_02_13_429885	415	2	covariates	covariate	NNS
10_1101-2021_02_13_429885	415	3	are	be	VBP
10_1101-2021_02_13_429885	415	4	similar	similar	JJ
10_1101-2021_02_13_429885	415	5	to	to	IN
10_1101-2021_02_13_429885	415	6	those	those	DT
10_1101-2021_02_13_429885	415	7	used	use	VBN
10_1101-2021_02_13_429885	415	8	to	to	TO
10_1101-2021_02_13_429885	415	9	infer	infer	VB
10_1101-2021_02_13_429885	415	10	CNA	cna	NN
10_1101-2021_02_13_429885	415	11	signatures	signature	NNS
10_1101-2021_02_13_429885	415	12	from	from	IN
10_1101-2021_02_13_429885	415	13	single	single	JJ
10_1101-2021_02_13_429885	415	14	-	-	HYPH
10_1101-2021_02_13_429885	415	15	cell	cell	NN
10_1101-2021_02_13_429885	415	16	low	low	JJ
10_1101-2021_02_13_429885	415	17	-	-	HYPH
10_1101-2021_02_13_429885	415	18	pass	pass	NN
10_1101-2021_02_13_429885	415	19	WGS	WGS	NNP
10_1101-2021_02_13_429885	415	20	​(Macintyre	​(Macintyre	NNP
10_1101-2021_02_13_429885	415	21	et	et	FW
10_1101-2021_02_13_429885	415	22	al	al	NNP
10_1101-2021_02_13_429885	415	23	.	.	.
10_1101-2021_02_13_429885	416	1	2018	2018	CD
10_1101-2021_02_13_429885	416	2	)	)	-RRB-
10_1101-2021_02_13_429885	416	3	​.	​.	ADD
10_1101-2021_02_13_429885	417	1	Other	other	JJ
10_1101-2021_02_13_429885	417	2	features	feature	NNS
10_1101-2021_02_13_429885	417	3	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	417	4	contains	contain	VBZ
10_1101-2021_02_13_429885	417	5	multiple	multiple	JJ
10_1101-2021_02_13_429885	417	6	functions	function	NNS
10_1101-2021_02_13_429885	417	7	to	to	TO
10_1101-2021_02_13_429885	417	8	subset	subset	VB
10_1101-2021_02_13_429885	417	9	the	the	DT
10_1101-2021_02_13_429885	417	10	data	datum	NNS
10_1101-2021_02_13_429885	417	11	(	(	-LRB-
10_1101-2021_02_13_429885	417	12	i.e.	i.e.	FW
10_1101-2021_02_13_429885	417	13	,	,	,
10_1101-2021_02_13_429885	417	14	select	select	JJ
10_1101-2021_02_13_429885	417	15	mutations	mutation	NNS
10_1101-2021_02_13_429885	417	16	that	that	WDT
10_1101-2021_02_13_429885	417	17	map	map	VBP
10_1101-2021_02_13_429885	417	18	only	only	RB
10_1101-2021_02_13_429885	417	19	to	to	IN
10_1101-2021_02_13_429885	417	20	certain	certain	JJ
10_1101-2021_02_13_429885	417	21	copy	copy	NN
10_1101-2021_02_13_429885	417	22	states	state	NNS
10_1101-2021_02_13_429885	417	23	,	,	,
10_1101-2021_02_13_429885	417	24	subset	subset	VBP
10_1101-2021_02_13_429885	417	25	CNAs	cna	NNS
10_1101-2021_02_13_429885	417	26	with	with	IN
10_1101-2021_02_13_429885	417	27	a	a	DT
10_1101-2021_02_13_429885	417	28	total	total	JJ
10_1101-2021_02_13_429885	417	29	ploidy	ploidy	NN
10_1101-2021_02_13_429885	417	30	,	,	,
10_1101-2021_02_13_429885	417	31	etc	etc	FW
10_1101-2021_02_13_429885	417	32	.	.	.
10_1101-2021_02_13_429885	418	1	)	)	-RRB-
10_1101-2021_02_13_429885	418	2	,	,	,
10_1101-2021_02_13_429885	418	3	visualise	visualise	VB
10_1101-2021_02_13_429885	418	4	the	the	DT
10_1101-2021_02_13_429885	418	5	data	datum	NNS
10_1101-2021_02_13_429885	418	6	(	(	-LRB-
10_1101-2021_02_13_429885	418	7	i.e.	i.e.	FW
10_1101-2021_02_13_429885	418	8	,	,	,
10_1101-2021_02_13_429885	418	9	plot	plot	NN
10_1101-2021_02_13_429885	418	10	mutational	mutational	JJ
10_1101-2021_02_13_429885	418	11	burden	burden	NN
10_1101-2021_02_13_429885	418	12	by	by	IN
10_1101-2021_02_13_429885	418	13	tumour	tumour	NN
10_1101-2021_02_13_429885	418	14	genome	genome	NN
10_1101-2021_02_13_429885	418	15	)	)	-RRB-
10_1101-2021_02_13_429885	418	16	or	or	CC
10_1101-2021_02_13_429885	418	17	smooth	smooth	VB
10_1101-2021_02_13_429885	418	18	the	the	DT
10_1101-2021_02_13_429885	418	19	input	input	NN
10_1101-2021_02_13_429885	418	20	CNA	cna	NN
10_1101-2021_02_13_429885	418	21	segments	segment	NNS
10_1101-2021_02_13_429885	418	22	.	.	.
10_1101-2021_02_13_429885	419	1	Smoothing	smooth	VBG
10_1101-2021_02_13_429885	419	2	is	be	VBZ
10_1101-2021_02_13_429885	419	3	an	an	DT
10_1101-2021_02_13_429885	419	4	operation	operation	NN
10_1101-2021_02_13_429885	419	5	that	that	WDT
10_1101-2021_02_13_429885	419	6	can	can	MD
10_1101-2021_02_13_429885	419	7	be	be	VB
10_1101-2021_02_13_429885	419	8	carried	carry	VBN
10_1101-2021_02_13_429885	419	9	out	out	RP
10_1101-2021_02_13_429885	419	10	before	before	IN
10_1101-2021_02_13_429885	419	11	testing	test	VBG
10_1101-2021_02_13_429885	419	12	for	for	IN
10_1101-2021_02_13_429885	419	13	over	over	IN
10_1101-2021_02_13_429885	419	14	-	-	HYPH
10_1101-2021_02_13_429885	419	15	fragmentation	fragmentation	NN
10_1101-2021_02_13_429885	419	16	.	.	.
10_1101-2021_02_13_429885	420	1	In	in	IN
10_1101-2021_02_13_429885	420	2	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	420	3	,	,	,
10_1101-2021_02_13_429885	420	4	by	by	IN
10_1101-2021_02_13_429885	420	5	smoothing	smooth	VBG
10_1101-2021_02_13_429885	420	6	we	-PRON-	PRP
10_1101-2021_02_13_429885	420	7	obtain	obtain	VBP
10_1101-2021_02_13_429885	420	8	that	that	IN
10_1101-2021_02_13_429885	420	9	two	two	CD
10_1101-2021_02_13_429885	420	10	contiguous	contiguous	JJ
10_1101-2021_02_13_429885	420	11	segments	segment	NNS
10_1101-2021_02_13_429885	420	12	are	be	VBP
10_1101-2021_02_13_429885	420	13	merged	merge	VBN
10_1101-2021_02_13_429885	420	14	if	if	IN
10_1101-2021_02_13_429885	420	15	they	-PRON-	PRP
10_1101-2021_02_13_429885	420	16	have	have	VBP
10_1101-2021_02_13_429885	420	17	exactly	exactly	RB
10_1101-2021_02_13_429885	420	18	the	the	DT
10_1101-2021_02_13_429885	420	19	same	same	JJ
10_1101-2021_02_13_429885	420	20	ploidy	ploidy	NN
10_1101-2021_02_13_429885	420	21	profile	profile	NN
10_1101-2021_02_13_429885	420	22	(	(	-LRB-
10_1101-2021_02_13_429885	420	23	i.e.	i.e.	FW
10_1101-2021_02_13_429885	421	1	same	same	JJ
10_1101-2021_02_13_429885	421	2	numbers	number	NNS
10_1101-2021_02_13_429885	421	3	for	for	IN
10_1101-2021_02_13_429885	421	4	the	the	DT
10_1101-2021_02_13_429885	421	5	major	major	JJ
10_1101-2021_02_13_429885	421	6	and	and	CC
10_1101-2021_02_13_429885	421	7	minor	minor	JJ
10_1101-2021_02_13_429885	421	8	.CC	.CC	NFP
10_1101-2021_02_13_429885	421	9	-	-	HYPH
10_1101-2021_02_13_429885	421	10	BY	by	IN
10_1101-2021_02_13_429885	421	11	-	-	HYPH
10_1101-2021_02_13_429885	421	12	NC	NC	NNP
10_1101-2021_02_13_429885	421	13	-	-	HYPH
10_1101-2021_02_13_429885	421	14	ND	ND	NNP
10_1101-2021_02_13_429885	421	15	4.0	4.0	CD
10_1101-2021_02_13_429885	421	16	International	International	NNP
10_1101-2021_02_13_429885	421	17	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	421	18	under	under	IN
10_1101-2021_02_13_429885	421	19	a	a	DT
10_1101-2021_02_13_429885	421	20	(	(	-LRB-
10_1101-2021_02_13_429885	421	21	which	which	WDT
10_1101-2021_02_13_429885	421	22	was	be	VBD
10_1101-2021_02_13_429885	421	23	not	not	RB
10_1101-2021_02_13_429885	421	24	certified	certify	VBN
10_1101-2021_02_13_429885	421	25	by	by	IN
10_1101-2021_02_13_429885	421	26	peer	peer	NN
10_1101-2021_02_13_429885	421	27	review	review	NN
10_1101-2021_02_13_429885	421	28	)	)	-RRB-
10_1101-2021_02_13_429885	421	29	is	be	VBZ
10_1101-2021_02_13_429885	421	30	the	the	DT
10_1101-2021_02_13_429885	421	31	author	author	NN
10_1101-2021_02_13_429885	421	32	/	/	SYM
10_1101-2021_02_13_429885	421	33	funder	funder	NN
10_1101-2021_02_13_429885	421	34	,	,	,
10_1101-2021_02_13_429885	421	35	who	who	WP
10_1101-2021_02_13_429885	421	36	has	have	VBZ
10_1101-2021_02_13_429885	421	37	granted	grant	VBN
10_1101-2021_02_13_429885	421	38	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	421	39	a	a	DT
10_1101-2021_02_13_429885	421	40	license	license	NN
10_1101-2021_02_13_429885	421	41	to	to	TO
10_1101-2021_02_13_429885	421	42	display	display	VB
10_1101-2021_02_13_429885	421	43	the	the	DT
10_1101-2021_02_13_429885	421	44	preprint	preprint	NN
10_1101-2021_02_13_429885	421	45	in	in	IN
10_1101-2021_02_13_429885	421	46	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	421	47	.	.	.
10_1101-2021_02_13_429885	422	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	422	2	is	be	VBZ
10_1101-2021_02_13_429885	422	3	made	make	VBN
10_1101-2021_02_13_429885	422	4	The	the	DT
10_1101-2021_02_13_429885	422	5	copyright	copyright	NN
10_1101-2021_02_13_429885	422	6	holder	holder	NN
10_1101-2021_02_13_429885	422	7	for	for	IN
10_1101-2021_02_13_429885	422	8	this	this	DT
10_1101-2021_02_13_429885	422	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	422	10	version	version	NN
10_1101-2021_02_13_429885	422	11	posted	post	VBD
10_1101-2021_02_13_429885	422	12	February	February	NNP
10_1101-2021_02_13_429885	422	13	13	13	CD
10_1101-2021_02_13_429885	422	14	,	,	,
10_1101-2021_02_13_429885	422	15	2021	2021	CD
10_1101-2021_02_13_429885	422	16	.	.	.
10_1101-2021_02_13_429885	422	17	;	;	:
10_1101-2021_02_13_429885	422	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	422	19	:	:	:
10_1101-2021_02_13_429885	422	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	422	21	preprint	preprint	NN
10_1101-2021_02_13_429885	422	22	https://paperpile.com/c/rqVmzs/FjZP	https://paperpile.com/c/rqvmzs/fjzp	ADD
10_1101-2021_02_13_429885	422	23	https://paperpile.com/c/rqVmzs/FjZP	https://paperpile.com/c/rqVmzs/FjZP	NNP
10_1101-2021_02_13_429885	422	24	https://paperpile.com/c/rqVmzs/P1Yv	https://paperpile.com/c/rqVmzs/P1Yv	NNP
10_1101-2021_02_13_429885	422	25	https://paperpile.com/c/rqVmzs/P1Yv	https://paperpile.com/c/rqVmzs/P1Yv	NNP
10_1101-2021_02_13_429885	422	26	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	422	27	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	422	28	Househam	Househam	NNP
10_1101-2021_02_13_429885	422	29	et	et	FW
10_1101-2021_02_13_429885	422	30	al	al	NNP
10_1101-2021_02_13_429885	422	31	.	.	.
10_1101-2021_02_13_429885	423	1	A	a	DT
10_1101-2021_02_13_429885	423	2	fully	fully	RB
10_1101-2021_02_13_429885	423	3	automated	automate	VBN
10_1101-2021_02_13_429885	423	4	approach	approach	NN
10_1101-2021_02_13_429885	423	5	for	for	IN
10_1101-2021_02_13_429885	423	6	quality	quality	NN
10_1101-2021_02_13_429885	423	7	control	control	NN
10_1101-2021_02_13_429885	423	8	of	of	IN
10_1101-2021_02_13_429885	423	9	cancer	cancer	NN
10_1101-2021_02_13_429885	423	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	423	11	in	in	IN
10_1101-2021_02_13_429885	423	12	the	the	DT
10_1101-2021_02_13_429885	423	13	era	era	NN
10_1101-2021_02_13_429885	423	14	of	of	IN
10_1101-2021_02_13_429885	423	15	high	high	JJ
10_1101-2021_02_13_429885	423	16	-	-	HYPH
10_1101-2021_02_13_429885	423	17	resolution	resolution	NN
10_1101-2021_02_13_429885	423	18	whole	whole	JJ
10_1101-2021_02_13_429885	423	19	genome	genome	JJ
10_1101-2021_02_13_429885	423	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	423	21	.	.	.
10_1101-2021_02_13_429885	424	1	alleles	alleles	NNP
10_1101-2021_02_13_429885	424	2	)	)	-RRB-
10_1101-2021_02_13_429885	424	3	,	,	,
10_1101-2021_02_13_429885	424	4	and	and	CC
10_1101-2021_02_13_429885	424	5	if	if	IN
10_1101-2021_02_13_429885	424	6	they	-PRON-	PRP
10_1101-2021_02_13_429885	424	7	are	be	VBP
10_1101-2021_02_13_429885	424	8	a	a	DT
10_1101-2021_02_13_429885	424	9	maximum	maximum	JJ
10_1101-2021_02_13_429885	424	10	distance	distance	NN
10_1101-2021_02_13_429885	424	11	apart	apart	RB
10_1101-2021_02_13_429885	424	12	(	(	-LRB-
10_1101-2021_02_13_429885	424	13	e.g.	e.g.	RB
10_1101-2021_02_13_429885	425	1	1	1	CD
10_1101-2021_02_13_429885	425	2	megabase	megabase	NN
10_1101-2021_02_13_429885	425	3	)	)	-RRB-
10_1101-2021_02_13_429885	425	4	.	.	.
10_1101-2021_02_13_429885	426	1	This	this	DT
10_1101-2021_02_13_429885	426	2	operation	operation	NN
10_1101-2021_02_13_429885	426	3	does	do	VBZ
10_1101-2021_02_13_429885	426	4	not	not	RB
10_1101-2021_02_13_429885	426	5	affect	affect	VB
10_1101-2021_02_13_429885	426	6	the	the	DT
10_1101-2021_02_13_429885	426	7	ploidy	ploidy	NN
10_1101-2021_02_13_429885	426	8	profile	profile	NN
10_1101-2021_02_13_429885	426	9	of	of	IN
10_1101-2021_02_13_429885	426	10	the	the	DT
10_1101-2021_02_13_429885	426	11	calls	call	NNS
10_1101-2021_02_13_429885	426	12	,	,	,
10_1101-2021_02_13_429885	426	13	but	but	CC
10_1101-2021_02_13_429885	426	14	reduces	reduce	VBZ
10_1101-2021_02_13_429885	426	15	the	the	DT
10_1101-2021_02_13_429885	426	16	amount	amount	NN
10_1101-2021_02_13_429885	426	17	of	of	IN
10_1101-2021_02_13_429885	426	18	breakpoints	breakpoint	NNS
10_1101-2021_02_13_429885	426	19	that	that	WDT
10_1101-2021_02_13_429885	426	20	would	would	MD
10_1101-2021_02_13_429885	426	21	inflate	inflate	VB
10_1101-2021_02_13_429885	426	22	the	the	DT
10_1101-2021_02_13_429885	426	23	p	p	NN
10_1101-2021_02_13_429885	426	24	-	-	HYPH
10_1101-2021_02_13_429885	426	25	value	value	NN
10_1101-2021_02_13_429885	426	26	of	of	IN
10_1101-2021_02_13_429885	426	27	the	the	DT
10_1101-2021_02_13_429885	426	28	Binomial	Binomial	NNP
10_1101-2021_02_13_429885	426	29	over	over	IN
10_1101-2021_02_13_429885	426	30	-	-	HYPH
10_1101-2021_02_13_429885	426	31	fragmentation	fragmentation	NN
10_1101-2021_02_13_429885	426	32	test	test	NN
10_1101-2021_02_13_429885	426	33	.	.	.
10_1101-2021_02_13_429885	427	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	427	2	-	-	:
10_1101-2021_02_13_429885	427	3	BY	by	IN
10_1101-2021_02_13_429885	427	4	-	-	HYPH
10_1101-2021_02_13_429885	427	5	NC	NC	NNP
10_1101-2021_02_13_429885	427	6	-	-	HYPH
10_1101-2021_02_13_429885	427	7	ND	ND	NNP
10_1101-2021_02_13_429885	427	8	4.0	4.0	CD
10_1101-2021_02_13_429885	427	9	International	International	NNP
10_1101-2021_02_13_429885	427	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	427	11	under	under	IN
10_1101-2021_02_13_429885	427	12	a	a	DT
10_1101-2021_02_13_429885	427	13	(	(	-LRB-
10_1101-2021_02_13_429885	427	14	which	which	WDT
10_1101-2021_02_13_429885	427	15	was	be	VBD
10_1101-2021_02_13_429885	427	16	not	not	RB
10_1101-2021_02_13_429885	427	17	certified	certify	VBN
10_1101-2021_02_13_429885	427	18	by	by	IN
10_1101-2021_02_13_429885	427	19	peer	peer	NN
10_1101-2021_02_13_429885	427	20	review	review	NN
10_1101-2021_02_13_429885	427	21	)	)	-RRB-
10_1101-2021_02_13_429885	427	22	is	be	VBZ
10_1101-2021_02_13_429885	427	23	the	the	DT
10_1101-2021_02_13_429885	427	24	author	author	NN
10_1101-2021_02_13_429885	427	25	/	/	SYM
10_1101-2021_02_13_429885	427	26	funder	funder	NN
10_1101-2021_02_13_429885	427	27	,	,	,
10_1101-2021_02_13_429885	427	28	who	who	WP
10_1101-2021_02_13_429885	427	29	has	have	VBZ
10_1101-2021_02_13_429885	427	30	granted	grant	VBN
10_1101-2021_02_13_429885	427	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	427	32	a	a	DT
10_1101-2021_02_13_429885	427	33	license	license	NN
10_1101-2021_02_13_429885	427	34	to	to	TO
10_1101-2021_02_13_429885	427	35	display	display	VB
10_1101-2021_02_13_429885	427	36	the	the	DT
10_1101-2021_02_13_429885	427	37	preprint	preprint	NN
10_1101-2021_02_13_429885	427	38	in	in	IN
10_1101-2021_02_13_429885	427	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	427	40	.	.	.
10_1101-2021_02_13_429885	428	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	428	2	is	be	VBZ
10_1101-2021_02_13_429885	428	3	made	make	VBN
10_1101-2021_02_13_429885	428	4	The	the	DT
10_1101-2021_02_13_429885	428	5	copyright	copyright	NN
10_1101-2021_02_13_429885	428	6	holder	holder	NN
10_1101-2021_02_13_429885	428	7	for	for	IN
10_1101-2021_02_13_429885	428	8	this	this	DT
10_1101-2021_02_13_429885	428	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	428	10	version	version	NN
10_1101-2021_02_13_429885	428	11	posted	post	VBD
10_1101-2021_02_13_429885	428	12	February	February	NNP
10_1101-2021_02_13_429885	428	13	13	13	CD
10_1101-2021_02_13_429885	428	14	,	,	,
10_1101-2021_02_13_429885	428	15	2021	2021	CD
10_1101-2021_02_13_429885	428	16	.	.	.
10_1101-2021_02_13_429885	428	17	;	;	:
10_1101-2021_02_13_429885	428	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	428	19	:	:	:
10_1101-2021_02_13_429885	428	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	428	21	preprint	preprint	NN
10_1101-2021_02_13_429885	428	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	428	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	428	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	428	25	et	et	FW
10_1101-2021_02_13_429885	428	26	al	al	NNP
10_1101-2021_02_13_429885	428	27	.	.	.
10_1101-2021_02_13_429885	429	1	A	a	DT
10_1101-2021_02_13_429885	429	2	fully	fully	RB
10_1101-2021_02_13_429885	429	3	automated	automate	VBN
10_1101-2021_02_13_429885	429	4	approach	approach	NN
10_1101-2021_02_13_429885	429	5	for	for	IN
10_1101-2021_02_13_429885	429	6	quality	quality	NN
10_1101-2021_02_13_429885	429	7	control	control	NN
10_1101-2021_02_13_429885	429	8	of	of	IN
10_1101-2021_02_13_429885	429	9	cancer	cancer	NN
10_1101-2021_02_13_429885	429	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	429	11	in	in	IN
10_1101-2021_02_13_429885	429	12	the	the	DT
10_1101-2021_02_13_429885	429	13	era	era	NN
10_1101-2021_02_13_429885	429	14	of	of	IN
10_1101-2021_02_13_429885	429	15	high	high	JJ
10_1101-2021_02_13_429885	429	16	-	-	HYPH
10_1101-2021_02_13_429885	429	17	resolution	resolution	NN
10_1101-2021_02_13_429885	429	18	whole	whole	JJ
10_1101-2021_02_13_429885	429	19	genome	genome	JJ
10_1101-2021_02_13_429885	429	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	429	21	.	.	.
10_1101-2021_02_13_429885	430	1	Main	Main	NNP
10_1101-2021_02_13_429885	430	2	Text	Text	NNP
10_1101-2021_02_13_429885	430	3	Figures	Figures	NNPS
10_1101-2021_02_13_429885	430	4	Figure	Figure	NNP
10_1101-2021_02_13_429885	430	5	1	1	CD
10_1101-2021_02_13_429885	430	6	.	.	.
10_1101-2021_02_13_429885	430	7	a.	a.	NN
10_1101-2021_02_13_429885	431	1	​Theoretical	​Theoretical	NNP
10_1101-2021_02_13_429885	431	2	​VAF	​VAF	NNP
10_1101-2021_02_13_429885	431	3	histogram	histogram	NNP
10_1101-2021_02_13_429885	431	4	for	for	IN
10_1101-2021_02_13_429885	431	5	diploid	diploid	NNP
10_1101-2021_02_13_429885	431	6	1:1	1:1	NNP
10_1101-2021_02_13_429885	431	7	mutations	mutation	NNS
10_1101-2021_02_13_429885	431	8	in	in	IN
10_1101-2021_02_13_429885	431	9	a	a	DT
10_1101-2021_02_13_429885	431	10	tumour	tumour	NN
10_1101-2021_02_13_429885	431	11	.	.	.
10_1101-2021_02_13_429885	432	1	A	a	DT
10_1101-2021_02_13_429885	432	2	clonal	clonal	JJ
10_1101-2021_02_13_429885	432	3	heterozygous	heterozygous	JJ
10_1101-2021_02_13_429885	432	4	mutation	mutation	NN
10_1101-2021_02_13_429885	432	5	has	have	VBZ
10_1101-2021_02_13_429885	432	6	50	50	CD
10_1101-2021_02_13_429885	432	7	%	%	NN
10_1101-2021_02_13_429885	432	8	VAF	VAF	NNP
10_1101-2021_02_13_429885	432	9	;	;	:
10_1101-2021_02_13_429885	432	10	all	all	DT
10_1101-2021_02_13_429885	432	11	mutations	mutation	NNS
10_1101-2021_02_13_429885	432	12	are	be	VBP
10_1101-2021_02_13_429885	432	13	observed	observe	VBN
10_1101-2021_02_13_429885	432	14	with	with	IN
10_1101-2021_02_13_429885	432	15	some	some	DT
10_1101-2021_02_13_429885	432	16	Binomial	Binomial	NNP
10_1101-2021_02_13_429885	432	17	sequencing	sequencing	NN
10_1101-2021_02_13_429885	432	18	noise	noise	NN
10_1101-2021_02_13_429885	432	19	.	.	.
10_1101-2021_02_13_429885	433	1	The	the	DT
10_1101-2021_02_13_429885	433	2	clonal	clonal	JJ
10_1101-2021_02_13_429885	433	3	mutations	mutation	NNS
10_1101-2021_02_13_429885	433	4	form	form	VBP
10_1101-2021_02_13_429885	433	5	a	a	DT
10_1101-2021_02_13_429885	433	6	peak	peak	NN
10_1101-2021_02_13_429885	433	7	at	at	IN
10_1101-2021_02_13_429885	433	8	100	100	CD
10_1101-2021_02_13_429885	433	9	%	%	NN
10_1101-2021_02_13_429885	433	10	CCF	CCF	NNP
10_1101-2021_02_13_429885	433	11	,	,	,
10_1101-2021_02_13_429885	433	12	plus	plus	CC
10_1101-2021_02_13_429885	433	13	other	other	JJ
10_1101-2021_02_13_429885	433	14	features	feature	NNS
10_1101-2021_02_13_429885	433	15	that	that	WDT
10_1101-2021_02_13_429885	433	16	characterise	characterise	VBP
10_1101-2021_02_13_429885	433	17	the	the	DT
10_1101-2021_02_13_429885	433	18	tumour	tumour	NN
10_1101-2021_02_13_429885	433	19	clonal	clonal	JJ
10_1101-2021_02_13_429885	433	20	composition	composition	NN
10_1101-2021_02_13_429885	433	21	(	(	-LRB-
10_1101-2021_02_13_429885	433	22	e.g.	e.g.	RB
10_1101-2021_02_13_429885	433	23	,	,	,
10_1101-2021_02_13_429885	433	24	the	the	DT
10_1101-2021_02_13_429885	433	25	tail	tail	NN
10_1101-2021_02_13_429885	433	26	)	)	-RRB-
10_1101-2021_02_13_429885	433	27	.	.	.
10_1101-2021_02_13_429885	434	1	The	the	DT
10_1101-2021_02_13_429885	434	2	expected	expect	VBN
10_1101-2021_02_13_429885	434	3	theoretical	theoretical	JJ
10_1101-2021_02_13_429885	434	4	VAF	VAF	NNP
10_1101-2021_02_13_429885	434	5	decreases	decrease	NNS
10_1101-2021_02_13_429885	434	6	if	if	IN
10_1101-2021_02_13_429885	434	7	sample	sample	NN
10_1101-2021_02_13_429885	434	8	purity	purity	NN
10_1101-2021_02_13_429885	434	9	reduces	reduce	NNS
10_1101-2021_02_13_429885	434	10	.	.	.
10_1101-2021_02_13_429885	435	1	​b	​b	NNP
10_1101-2021_02_13_429885	435	2	.	.	.
10_1101-2021_02_13_429885	436	1	The	the	DT
10_1101-2021_02_13_429885	436	2	case	case	NN
10_1101-2021_02_13_429885	436	3	of	of	IN
10_1101-2021_02_13_429885	436	4	a	a	DT
10_1101-2021_02_13_429885	436	5	2:1	2:1	CD
10_1101-2021_02_13_429885	436	6	tumour	tumour	NN
10_1101-2021_02_13_429885	436	7	genome	genome	NN
10_1101-2021_02_13_429885	436	8	,	,	,
10_1101-2021_02_13_429885	436	9	where	where	WRB
10_1101-2021_02_13_429885	436	10	we	-PRON-	PRP
10_1101-2021_02_13_429885	436	11	expect	expect	VBP
10_1101-2021_02_13_429885	436	12	2	2	CD
10_1101-2021_02_13_429885	436	13	peaks	peak	NNS
10_1101-2021_02_13_429885	436	14	in	in	IN
10_1101-2021_02_13_429885	436	15	the	the	DT
10_1101-2021_02_13_429885	436	16	VAF	VAF	NNP
10_1101-2021_02_13_429885	436	17	originating	originate	VBG
10_1101-2021_02_13_429885	436	18	from	from	IN
10_1101-2021_02_13_429885	436	19	mutations	mutation	NNS
10_1101-2021_02_13_429885	436	20	present	present	JJ
10_1101-2021_02_13_429885	436	21	in	in	IN
10_1101-2021_02_13_429885	436	22	one	one	CD
10_1101-2021_02_13_429885	436	23	(	(	-LRB-
10_1101-2021_02_13_429885	436	24	orange	orange	NN
10_1101-2021_02_13_429885	436	25	)	)	-RRB-
10_1101-2021_02_13_429885	436	26	or	or	CC
10_1101-2021_02_13_429885	436	27	two	two	CD
10_1101-2021_02_13_429885	436	28	copies	copy	NNS
10_1101-2021_02_13_429885	436	29	(	(	-LRB-
10_1101-2021_02_13_429885	436	30	purple	purple	NNP
10_1101-2021_02_13_429885	436	31	)	)	-RRB-
10_1101-2021_02_13_429885	436	32	.	.	.
10_1101-2021_02_13_429885	437	1	The	the	DT
10_1101-2021_02_13_429885	437	2	multiplicity	multiplicity	NN
10_1101-2021_02_13_429885	437	3	of	of	IN
10_1101-2021_02_13_429885	437	4	a	a	DT
10_1101-2021_02_13_429885	437	5	mutation	mutation	NN
10_1101-2021_02_13_429885	437	6	can	can	MD
10_1101-2021_02_13_429885	437	7	phase	phase	VB
10_1101-2021_02_13_429885	437	8	whether	whether	IN
10_1101-2021_02_13_429885	437	9	it	-PRON-	PRP
10_1101-2021_02_13_429885	437	10	happened	happen	VBD
10_1101-2021_02_13_429885	437	11	before	before	IN
10_1101-2021_02_13_429885	437	12	or	or	CC
10_1101-2021_02_13_429885	437	13	after	after	IN
10_1101-2021_02_13_429885	437	14	the	the	DT
10_1101-2021_02_13_429885	437	15	CNA	CNA	NNP
10_1101-2021_02_13_429885	437	16	.	.	.
10_1101-2021_02_13_429885	438	1	For	for	IN
10_1101-2021_02_13_429885	438	2	2:1	2:1	CD
10_1101-2021_02_13_429885	438	3	we	-PRON-	PRP
10_1101-2021_02_13_429885	438	4	expect	expect	VBP
10_1101-2021_02_13_429885	438	5	peaks	peak	NNS
10_1101-2021_02_13_429885	438	6	at	at	IN
10_1101-2021_02_13_429885	438	7	66	66	CD
10_1101-2021_02_13_429885	438	8	%	%	NN
10_1101-2021_02_13_429885	438	9	and	and	CC
10_1101-2021_02_13_429885	438	10	33	33	CD
10_1101-2021_02_13_429885	438	11	%	%	NN
10_1101-2021_02_13_429885	438	12	VAF	VAF	NNP
10_1101-2021_02_13_429885	438	13	,	,	,
10_1101-2021_02_13_429885	438	14	both	both	CC
10_1101-2021_02_13_429885	438	15	clonal	clonal	JJ
10_1101-2021_02_13_429885	438	16	mutations	mutation	NNS
10_1101-2021_02_13_429885	438	17	(	(	-LRB-
10_1101-2021_02_13_429885	438	18	100	100	CD
10_1101-2021_02_13_429885	438	19	%	%	NN
10_1101-2021_02_13_429885	438	20	CCF	CCF	NNP
10_1101-2021_02_13_429885	438	21	)	)	-RRB-
10_1101-2021_02_13_429885	438	22	.	.	.
10_1101-2021_02_13_429885	439	1	​c	​c	NNP
10_1101-2021_02_13_429885	439	2	.	.	.
10_1101-2021_02_13_429885	440	1	​Computing	​compute	VBG
10_1101-2021_02_13_429885	440	2	CCFs	ccf	NNS
10_1101-2021_02_13_429885	440	3	requires	require	VBZ
10_1101-2021_02_13_429885	440	4	caution	caution	NN
10_1101-2021_02_13_429885	440	5	for	for	IN
10_1101-2021_02_13_429885	440	6	mutations	mutation	NNS
10_1101-2021_02_13_429885	440	7	with	with	IN
10_1101-2021_02_13_429885	440	8	different	different	JJ
10_1101-2021_02_13_429885	440	9	multiplicities	multiplicity	NNS
10_1101-2021_02_13_429885	440	10	;	;	:
10_1101-2021_02_13_429885	440	11	we	-PRON-	PRP
10_1101-2021_02_13_429885	440	12	support	support	VBP
10_1101-2021_02_13_429885	440	13	2:0	2:0	CD
10_1101-2021_02_13_429885	440	14	,	,	,
10_1101-2021_02_13_429885	440	15	2:1	2:1	CD
10_1101-2021_02_13_429885	440	16	and	and	CC
10_1101-2021_02_13_429885	440	17	2:2	2:2	CD
10_1101-2021_02_13_429885	440	18	copy	copy	NN
10_1101-2021_02_13_429885	440	19	states	state	NNS
10_1101-2021_02_13_429885	440	20	in	in	IN
10_1101-2021_02_13_429885	440	21	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	440	22	,	,	,
10_1101-2021_02_13_429885	440	23	and	and	CC
10_1101-2021_02_13_429885	440	24	offer	offer	VB
10_1101-2021_02_13_429885	440	25	two	two	CD
10_1101-2021_02_13_429885	440	26	methods	method	NNS
10_1101-2021_02_13_429885	440	27	to	to	TO
10_1101-2021_02_13_429885	440	28	compute	compute	VB
10_1101-2021_02_13_429885	440	29	CCFs	ccf	NNS
10_1101-2021_02_13_429885	440	30	.	.	.
10_1101-2021_02_13_429885	441	1	The	the	DT
10_1101-2021_02_13_429885	441	2	one	one	NN
10_1101-2021_02_13_429885	441	3	depicted	depict	VBN
10_1101-2021_02_13_429885	441	4	is	be	VBZ
10_1101-2021_02_13_429885	441	5	based	base	VBN
10_1101-2021_02_13_429885	441	6	on	on	IN
10_1101-2021_02_13_429885	441	7	the	the	DT
10_1101-2021_02_13_429885	441	8	entropy	entropy	NN
10_1101-2021_02_13_429885	441	9	of	of	IN
10_1101-2021_02_13_429885	441	10	a	a	DT
10_1101-2021_02_13_429885	441	11	Binomial	Binomial	NNP
10_1101-2021_02_13_429885	441	12	mixture	mixture	NN
10_1101-2021_02_13_429885	441	13	.	.	.
10_1101-2021_02_13_429885	442	1	From	from	IN
10_1101-2021_02_13_429885	442	2	the	the	DT
10_1101-2021_02_13_429885	442	3	expected	expect	VBN
10_1101-2021_02_13_429885	442	4	VAF	VAF	NNP
10_1101-2021_02_13_429885	442	5	peaks	peak	NNS
10_1101-2021_02_13_429885	442	6	we	-PRON-	PRP
10_1101-2021_02_13_429885	442	7	construct	construct	VBP
10_1101-2021_02_13_429885	442	8	a	a	DT
10_1101-2021_02_13_429885	442	9	mixture	mixture	NN
10_1101-2021_02_13_429885	442	10	density	density	NN
10_1101-2021_02_13_429885	442	11	and	and	CC
10_1101-2021_02_13_429885	442	12	use	use	VB
10_1101-2021_02_13_429885	442	13	the	the	DT
10_1101-2021_02_13_429885	442	14	entropy	entropy	NN
10_1101-2021_02_13_429885	442	15	of	of	IN
10_1101-2021_02_13_429885	442	16	its	-PRON-	PRP$
10_1101-2021_02_13_429885	442	17	latent	latent	NN
10_1101-2021_02_13_429885	442	18	variables	variable	NNS
10_1101-2021_02_13_429885	442	19	to	to	TO
10_1101-2021_02_13_429885	442	20	capture	capture	VB
10_1101-2021_02_13_429885	442	21	uncertainty	uncertainty	NN
10_1101-2021_02_13_429885	442	22	in	in	IN
10_1101-2021_02_13_429885	442	23	the	the	DT
10_1101-2021_02_13_429885	442	24	multiplicities	multiplicity	NNS
10_1101-2021_02_13_429885	442	25	.	.	.
10_1101-2021_02_13_429885	443	1	At	at	IN
10_1101-2021_02_13_429885	443	2	the	the	DT
10_1101-2021_02_13_429885	443	3	crossing	crossing	NN
10_1101-2021_02_13_429885	443	4	of	of	IN
10_1101-2021_02_13_429885	443	5	the	the	DT
10_1101-2021_02_13_429885	443	6	components	component	NNS
10_1101-2021_02_13_429885	443	7	we	-PRON-	PRP
10_1101-2021_02_13_429885	443	8	can	can	MD
10_1101-2021_02_13_429885	443	9	not	not	RB
10_1101-2021_02_13_429885	443	10	easily	easily	RB
10_1101-2021_02_13_429885	443	11	assign	assign	VB
10_1101-2021_02_13_429885	443	12	multiplicities	multiplicity	NNS
10_1101-2021_02_13_429885	443	13	,	,	,
10_1101-2021_02_13_429885	443	14	and	and	CC
10_1101-2021_02_13_429885	443	15	therefore	therefore	RB
10_1101-2021_02_13_429885	443	16	CCFs	ccf	NNS
10_1101-2021_02_13_429885	443	17	;	;	:
10_1101-2021_02_13_429885	443	18	the	the	DT
10_1101-2021_02_13_429885	443	19	entropy	entropy	JJ
10_1101-2021_02_13_429885	443	20	peaks	peak	NNS
10_1101-2021_02_13_429885	443	21	at	at	IN
10_1101-2021_02_13_429885	443	22	the	the	DT
10_1101-2021_02_13_429885	443	23	top	top	NN
10_1101-2021_02_13_429885	443	24	of	of	IN
10_1101-2021_02_13_429885	443	25	the	the	DT
10_1101-2021_02_13_429885	443	26	uncertainty	uncertainty	NN
10_1101-2021_02_13_429885	443	27	by	by	IN
10_1101-2021_02_13_429885	443	28	definition	definition	NN
10_1101-2021_02_13_429885	443	29	.	.	.
10_1101-2021_02_13_429885	444	1	​d	​d	LS
10_1101-2021_02_13_429885	444	2	.	.	.
10_1101-2021_02_13_429885	445	1	​Heatmap	​Heatmap	NNP
10_1101-2021_02_13_429885	445	2	expressing	express	VBG
10_1101-2021_02_13_429885	445	3	the	the	DT
10_1101-2021_02_13_429885	445	4	relationship	relationship	NN
10_1101-2021_02_13_429885	445	5	between	between	IN
10_1101-2021_02_13_429885	445	6	copy	copy	NN
10_1101-2021_02_13_429885	445	7	states	state	NNS
10_1101-2021_02_13_429885	445	8	,	,	,
10_1101-2021_02_13_429885	445	9	mutation	mutation	NN
10_1101-2021_02_13_429885	445	10	multiplicity	multiplicity	NN
10_1101-2021_02_13_429885	445	11	and	and	CC
10_1101-2021_02_13_429885	445	12	sample	sample	NN
10_1101-2021_02_13_429885	445	13	purity	purity	NN
10_1101-2021_02_13_429885	445	14	.	.	.
10_1101-2021_02_13_429885	446	1	The	the	DT
10_1101-2021_02_13_429885	446	2	color	color	NN
10_1101-2021_02_13_429885	446	3	reflects	reflect	VBZ
10_1101-2021_02_13_429885	446	4	the	the	DT
10_1101-2021_02_13_429885	446	5	expected	expect	VBN
10_1101-2021_02_13_429885	446	6	VAF	VAF	NNP
10_1101-2021_02_13_429885	446	7	for	for	IN
10_1101-2021_02_13_429885	446	8	the	the	DT
10_1101-2021_02_13_429885	446	9	corresponding	corresponding	JJ
10_1101-2021_02_13_429885	446	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	446	11	,	,	,
10_1101-2021_02_13_429885	446	12	and	and	CC
10_1101-2021_02_13_429885	446	13	can	can	MD
10_1101-2021_02_13_429885	446	14	be	be	VB
10_1101-2021_02_13_429885	446	15	used	use	VBN
10_1101-2021_02_13_429885	446	16	to	to	IN
10_1101-2021_02_13_429885	446	17	QC	QC	NNP
10_1101-2021_02_13_429885	446	18	both	both	DT
10_1101-2021_02_13_429885	446	19	CNAs	cna	NNS
10_1101-2021_02_13_429885	446	20	and	and	CC
10_1101-2021_02_13_429885	446	21	purity	purity	NN
10_1101-2021_02_13_429885	446	22	estimates	estimate	NNS
10_1101-2021_02_13_429885	446	23	.	.	.
10_1101-2021_02_13_429885	447	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	447	2	-	-	:
10_1101-2021_02_13_429885	447	3	BY	by	IN
10_1101-2021_02_13_429885	447	4	-	-	HYPH
10_1101-2021_02_13_429885	447	5	NC	NC	NNP
10_1101-2021_02_13_429885	447	6	-	-	HYPH
10_1101-2021_02_13_429885	447	7	ND	ND	NNP
10_1101-2021_02_13_429885	447	8	4.0	4.0	CD
10_1101-2021_02_13_429885	447	9	International	International	NNP
10_1101-2021_02_13_429885	447	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	447	11	under	under	IN
10_1101-2021_02_13_429885	447	12	a	a	DT
10_1101-2021_02_13_429885	447	13	(	(	-LRB-
10_1101-2021_02_13_429885	447	14	which	which	WDT
10_1101-2021_02_13_429885	447	15	was	be	VBD
10_1101-2021_02_13_429885	447	16	not	not	RB
10_1101-2021_02_13_429885	447	17	certified	certify	VBN
10_1101-2021_02_13_429885	447	18	by	by	IN
10_1101-2021_02_13_429885	447	19	peer	peer	NN
10_1101-2021_02_13_429885	447	20	review	review	NN
10_1101-2021_02_13_429885	447	21	)	)	-RRB-
10_1101-2021_02_13_429885	447	22	is	be	VBZ
10_1101-2021_02_13_429885	447	23	the	the	DT
10_1101-2021_02_13_429885	447	24	author	author	NN
10_1101-2021_02_13_429885	447	25	/	/	SYM
10_1101-2021_02_13_429885	447	26	funder	funder	NN
10_1101-2021_02_13_429885	447	27	,	,	,
10_1101-2021_02_13_429885	447	28	who	who	WP
10_1101-2021_02_13_429885	447	29	has	have	VBZ
10_1101-2021_02_13_429885	447	30	granted	grant	VBN
10_1101-2021_02_13_429885	447	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	447	32	a	a	DT
10_1101-2021_02_13_429885	447	33	license	license	NN
10_1101-2021_02_13_429885	447	34	to	to	TO
10_1101-2021_02_13_429885	447	35	display	display	VB
10_1101-2021_02_13_429885	447	36	the	the	DT
10_1101-2021_02_13_429885	447	37	preprint	preprint	NN
10_1101-2021_02_13_429885	447	38	in	in	IN
10_1101-2021_02_13_429885	447	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	447	40	.	.	.
10_1101-2021_02_13_429885	448	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	448	2	is	be	VBZ
10_1101-2021_02_13_429885	448	3	made	make	VBN
10_1101-2021_02_13_429885	448	4	The	the	DT
10_1101-2021_02_13_429885	448	5	copyright	copyright	NN
10_1101-2021_02_13_429885	448	6	holder	holder	NN
10_1101-2021_02_13_429885	448	7	for	for	IN
10_1101-2021_02_13_429885	448	8	this	this	DT
10_1101-2021_02_13_429885	448	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	448	10	version	version	NN
10_1101-2021_02_13_429885	448	11	posted	post	VBD
10_1101-2021_02_13_429885	448	12	February	February	NNP
10_1101-2021_02_13_429885	448	13	13	13	CD
10_1101-2021_02_13_429885	448	14	,	,	,
10_1101-2021_02_13_429885	448	15	2021	2021	CD
10_1101-2021_02_13_429885	448	16	.	.	.
10_1101-2021_02_13_429885	448	17	;	;	:
10_1101-2021_02_13_429885	448	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	448	19	:	:	:
10_1101-2021_02_13_429885	448	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	448	21	preprint	preprint	NN
10_1101-2021_02_13_429885	448	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	448	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	448	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	448	25	et	et	FW
10_1101-2021_02_13_429885	448	26	al	al	NNP
10_1101-2021_02_13_429885	448	27	.	.	.
10_1101-2021_02_13_429885	449	1	A	a	DT
10_1101-2021_02_13_429885	449	2	fully	fully	RB
10_1101-2021_02_13_429885	449	3	automated	automate	VBN
10_1101-2021_02_13_429885	449	4	approach	approach	NN
10_1101-2021_02_13_429885	449	5	for	for	IN
10_1101-2021_02_13_429885	449	6	quality	quality	NN
10_1101-2021_02_13_429885	449	7	control	control	NN
10_1101-2021_02_13_429885	449	8	of	of	IN
10_1101-2021_02_13_429885	449	9	cancer	cancer	NN
10_1101-2021_02_13_429885	449	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	449	11	in	in	IN
10_1101-2021_02_13_429885	449	12	the	the	DT
10_1101-2021_02_13_429885	449	13	era	era	NN
10_1101-2021_02_13_429885	449	14	of	of	IN
10_1101-2021_02_13_429885	449	15	high	high	JJ
10_1101-2021_02_13_429885	449	16	-	-	HYPH
10_1101-2021_02_13_429885	449	17	resolution	resolution	NN
10_1101-2021_02_13_429885	449	18	whole	whole	JJ
10_1101-2021_02_13_429885	449	19	genome	genome	JJ
10_1101-2021_02_13_429885	449	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	449	21	.	.	.
10_1101-2021_02_13_429885	450	1	Figure	figure	NN
10_1101-2021_02_13_429885	450	2	2	2	CD
10_1101-2021_02_13_429885	450	3	.	.	.
10_1101-2021_02_13_429885	450	4	a.	a.	NN
10_1101-2021_02_13_429885	450	5	Genome	genome	NN
10_1101-2021_02_13_429885	450	6	-	-	HYPH
10_1101-2021_02_13_429885	450	7	wide	wide	JJ
10_1101-2021_02_13_429885	450	8	total	total	JJ
10_1101-2021_02_13_429885	450	9	clonal	clonal	JJ
10_1101-2021_02_13_429885	450	10	copy	copy	NN
10_1101-2021_02_13_429885	450	11	number	number	NN
10_1101-2021_02_13_429885	450	12	segments	segment	NNS
10_1101-2021_02_13_429885	450	13	for	for	IN
10_1101-2021_02_13_429885	450	14	a	a	DT
10_1101-2021_02_13_429885	450	15	PCAWG	PCAWG	NNP
10_1101-2021_02_13_429885	450	16	cancer	cancer	NN
10_1101-2021_02_13_429885	450	17	sample	sample	NN
10_1101-2021_02_13_429885	450	18	with	with	IN
10_1101-2021_02_13_429885	450	19	overall	overall	JJ
10_1101-2021_02_13_429885	450	20	ploidy	ploidy	NN
10_1101-2021_02_13_429885	450	21	2	2	CD
10_1101-2021_02_13_429885	450	22	,	,	,
10_1101-2021_02_13_429885	450	23	and	and	CC
10_1101-2021_02_13_429885	450	24	sample	sample	VB
10_1101-2021_02_13_429885	450	25	purity	purity	NN
10_1101-2021_02_13_429885	450	26	~85	~85	NFP
10_1101-2021_02_13_429885	450	27	%	%	NN
10_1101-2021_02_13_429885	450	28	.	.	.
10_1101-2021_02_13_429885	451	1	The	the	DT
10_1101-2021_02_13_429885	451	2	panel	panel	NN
10_1101-2021_02_13_429885	451	3	is	be	VBZ
10_1101-2021_02_13_429885	451	4	composed	compose	VBN
10_1101-2021_02_13_429885	451	5	of	of	IN
10_1101-2021_02_13_429885	451	6	three	three	CD
10_1101-2021_02_13_429885	451	7	illustrations	illustration	NNS
10_1101-2021_02_13_429885	451	8	.	.	.
10_1101-2021_02_13_429885	452	1	The	the	DT
10_1101-2021_02_13_429885	452	2	bottom	bottom	JJ
10_1101-2021_02_13_429885	452	3	plot	plot	NN
10_1101-2021_02_13_429885	452	4	reports	report	VBZ
10_1101-2021_02_13_429885	452	5	the	the	DT
10_1101-2021_02_13_429885	452	6	copies	copy	NNS
10_1101-2021_02_13_429885	452	7	of	of	IN
10_1101-2021_02_13_429885	452	8	the	the	DT
10_1101-2021_02_13_429885	452	9	major	major	JJ
10_1101-2021_02_13_429885	452	10	and	and	CC
10_1101-2021_02_13_429885	452	11	minor	minor	JJ
10_1101-2021_02_13_429885	452	12	alleles	allele	NNS
10_1101-2021_02_13_429885	452	13	in	in	IN
10_1101-2021_02_13_429885	452	14	each	each	DT
10_1101-2021_02_13_429885	452	15	segment	segment	NN
10_1101-2021_02_13_429885	452	16	,	,	,
10_1101-2021_02_13_429885	452	17	and	and	CC
10_1101-2021_02_13_429885	452	18	some	some	DT
10_1101-2021_02_13_429885	452	19	genome	genome	JJ
10_1101-2021_02_13_429885	452	20	areas	area	NNS
10_1101-2021_02_13_429885	452	21	are	be	VBP
10_1101-2021_02_13_429885	452	22	shaded	shaded	JJ
10_1101-2021_02_13_429885	452	23	.	.	.
10_1101-2021_02_13_429885	453	1	The	the	DT
10_1101-2021_02_13_429885	453	2	central	central	JJ
10_1101-2021_02_13_429885	453	3	plot	plot	NN
10_1101-2021_02_13_429885	453	4	shows	show	VBZ
10_1101-2021_02_13_429885	453	5	genome	genome	JJ
10_1101-2021_02_13_429885	453	6	-	-	HYPH
10_1101-2021_02_13_429885	453	7	wide	wide	JJ
10_1101-2021_02_13_429885	453	8	somatic	somatic	JJ
10_1101-2021_02_13_429885	453	9	mutations	mutation	NNS
10_1101-2021_02_13_429885	453	10	with	with	IN
10_1101-2021_02_13_429885	453	11	their	-PRON-	PRP$
10_1101-2021_02_13_429885	453	12	depth	depth	NN
10_1101-2021_02_13_429885	453	13	of	of	IN
10_1101-2021_02_13_429885	453	14	sequencing	sequencing	NN
10_1101-2021_02_13_429885	453	15	,	,	,
10_1101-2021_02_13_429885	453	16	and	and	CC
10_1101-2021_02_13_429885	453	17	the	the	DT
10_1101-2021_02_13_429885	453	18	top	top	JJ
10_1101-2021_02_13_429885	453	19	plot	plot	NN
10_1101-2021_02_13_429885	453	20	shows	show	VBZ
10_1101-2021_02_13_429885	453	21	the	the	DT
10_1101-2021_02_13_429885	453	22	total	total	JJ
10_1101-2021_02_13_429885	453	23	number	number	NN
10_1101-2021_02_13_429885	453	24	of	of	IN
10_1101-2021_02_13_429885	453	25	mappable	mappable	JJ
10_1101-2021_02_13_429885	453	26	mutations	mutation	NNS
10_1101-2021_02_13_429885	453	27	binned	bin	VBD
10_1101-2021_02_13_429885	453	28	every	every	DT
10_1101-2021_02_13_429885	453	29	megabase	megabase	NN
10_1101-2021_02_13_429885	453	30	.	.	.
10_1101-2021_02_13_429885	454	1	​b	​b	NNP
10_1101-2021_02_13_429885	454	2	.	.	.
10_1101-2021_02_13_429885	455	1	Variant	Variant	NNP
10_1101-2021_02_13_429885	455	2	Allele	Allele	NNP
10_1101-2021_02_13_429885	455	3	Frequencies	Frequencies	NNPS
10_1101-2021_02_13_429885	455	4	(	(	-LRB-
10_1101-2021_02_13_429885	455	5	VAFs	VAFs	NNP
10_1101-2021_02_13_429885	455	6	)	)	-RRB-
10_1101-2021_02_13_429885	455	7	for	for	IN
10_1101-2021_02_13_429885	455	8	the	the	DT
10_1101-2021_02_13_429885	455	9	mutations	mutation	NNS
10_1101-2021_02_13_429885	455	10	that	that	WDT
10_1101-2021_02_13_429885	455	11	map	map	VBP
10_1101-2021_02_13_429885	455	12	to	to	IN
10_1101-2021_02_13_429885	455	13	the	the	DT
10_1101-2021_02_13_429885	455	14	input	input	NN
10_1101-2021_02_13_429885	455	15	segments	segment	NNS
10_1101-2021_02_13_429885	455	16	(	(	-LRB-
10_1101-2021_02_13_429885	455	17	note	note	VB
10_1101-2021_02_13_429885	455	18	that	that	IN
10_1101-2021_02_13_429885	455	19	these	these	DT
10_1101-2021_02_13_429885	455	20	are	be	VBP
10_1101-2021_02_13_429885	455	21	all	all	DT
10_1101-2021_02_13_429885	455	22	SNVs	SNVs	NNPS
10_1101-2021_02_13_429885	455	23	)	)	-RRB-
10_1101-2021_02_13_429885	455	24	.	.	.
10_1101-2021_02_13_429885	456	1	​c	​c	NNP
10_1101-2021_02_13_429885	456	2	.	.	.
10_1101-2021_02_13_429885	457	1	​Depth	​depth	NN
10_1101-2021_02_13_429885	457	2	of	of	IN
10_1101-2021_02_13_429885	457	3	sequencing	sequencing	NN
10_1101-2021_02_13_429885	457	4	(	(	-LRB-
10_1101-2021_02_13_429885	457	5	DP	DP	NNP
10_1101-2021_02_13_429885	457	6	)	)	-RRB-
10_1101-2021_02_13_429885	457	7	for	for	IN
10_1101-2021_02_13_429885	457	8	every	every	DT
10_1101-2021_02_13_429885	457	9	SNV	SNV	NNP
10_1101-2021_02_13_429885	457	10	.	.	.
10_1101-2021_02_13_429885	458	1	d.	d.	NNP
10_1101-2021_02_13_429885	458	2	Number	Number	NNP
10_1101-2021_02_13_429885	458	3	of	of	IN
10_1101-2021_02_13_429885	458	4	reads	read	NNS
10_1101-2021_02_13_429885	458	5	(	(	-LRB-
10_1101-2021_02_13_429885	458	6	NV	NV	NNP
10_1101-2021_02_13_429885	458	7	)	)	-RRB-
10_1101-2021_02_13_429885	458	8	with	with	IN
10_1101-2021_02_13_429885	458	9	the	the	DT
10_1101-2021_02_13_429885	458	10	variant	variant	JJ
10_1101-2021_02_13_429885	458	11	allele	allele	NN
10_1101-2021_02_13_429885	458	12	for	for	IN
10_1101-2021_02_13_429885	458	13	every	every	DT
10_1101-2021_02_13_429885	458	14	SNV	SNV	NNP
10_1101-2021_02_13_429885	458	15	.	.	.
10_1101-2021_02_13_429885	459	1	e.	e.	NNP
10_1101-2021_02_13_429885	459	2	​Cancer	​Cancer	NNP
10_1101-2021_02_13_429885	459	3	Cell	Cell	NNP
10_1101-2021_02_13_429885	459	4	Fractions	Fractions	NNPS
10_1101-2021_02_13_429885	459	5	(	(	-LRB-
10_1101-2021_02_13_429885	459	6	CCF	CCF	NNP
10_1101-2021_02_13_429885	459	7	)	)	-RRB-
10_1101-2021_02_13_429885	459	8	estimation	estimation	NN
10_1101-2021_02_13_429885	459	9	for	for	IN
10_1101-2021_02_13_429885	459	10	this	this	DT
10_1101-2021_02_13_429885	459	11	sample	sample	NN
10_1101-2021_02_13_429885	459	12	,	,	,
10_1101-2021_02_13_429885	459	13	obtained	obtain	VBN
10_1101-2021_02_13_429885	459	14	from	from	IN
10_1101-2021_02_13_429885	459	15	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	459	16	.	.	.
10_1101-2021_02_13_429885	460	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	460	2	-	-	:
10_1101-2021_02_13_429885	460	3	BY	by	IN
10_1101-2021_02_13_429885	460	4	-	-	HYPH
10_1101-2021_02_13_429885	460	5	NC	NC	NNP
10_1101-2021_02_13_429885	460	6	-	-	HYPH
10_1101-2021_02_13_429885	460	7	ND	ND	NNP
10_1101-2021_02_13_429885	460	8	4.0	4.0	CD
10_1101-2021_02_13_429885	460	9	International	International	NNP
10_1101-2021_02_13_429885	460	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	460	11	under	under	IN
10_1101-2021_02_13_429885	460	12	a	a	DT
10_1101-2021_02_13_429885	460	13	(	(	-LRB-
10_1101-2021_02_13_429885	460	14	which	which	WDT
10_1101-2021_02_13_429885	460	15	was	be	VBD
10_1101-2021_02_13_429885	460	16	not	not	RB
10_1101-2021_02_13_429885	460	17	certified	certify	VBN
10_1101-2021_02_13_429885	460	18	by	by	IN
10_1101-2021_02_13_429885	460	19	peer	peer	NN
10_1101-2021_02_13_429885	460	20	review	review	NN
10_1101-2021_02_13_429885	460	21	)	)	-RRB-
10_1101-2021_02_13_429885	460	22	is	be	VBZ
10_1101-2021_02_13_429885	460	23	the	the	DT
10_1101-2021_02_13_429885	460	24	author	author	NN
10_1101-2021_02_13_429885	460	25	/	/	SYM
10_1101-2021_02_13_429885	460	26	funder	funder	NN
10_1101-2021_02_13_429885	460	27	,	,	,
10_1101-2021_02_13_429885	460	28	who	who	WP
10_1101-2021_02_13_429885	460	29	has	have	VBZ
10_1101-2021_02_13_429885	460	30	granted	grant	VBN
10_1101-2021_02_13_429885	460	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	460	32	a	a	DT
10_1101-2021_02_13_429885	460	33	license	license	NN
10_1101-2021_02_13_429885	460	34	to	to	TO
10_1101-2021_02_13_429885	460	35	display	display	VB
10_1101-2021_02_13_429885	460	36	the	the	DT
10_1101-2021_02_13_429885	460	37	preprint	preprint	NN
10_1101-2021_02_13_429885	460	38	in	in	IN
10_1101-2021_02_13_429885	460	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	460	40	.	.	.
10_1101-2021_02_13_429885	461	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	461	2	is	be	VBZ
10_1101-2021_02_13_429885	461	3	made	make	VBN
10_1101-2021_02_13_429885	461	4	The	the	DT
10_1101-2021_02_13_429885	461	5	copyright	copyright	NN
10_1101-2021_02_13_429885	461	6	holder	holder	NN
10_1101-2021_02_13_429885	461	7	for	for	IN
10_1101-2021_02_13_429885	461	8	this	this	DT
10_1101-2021_02_13_429885	461	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	461	10	version	version	NN
10_1101-2021_02_13_429885	461	11	posted	post	VBD
10_1101-2021_02_13_429885	461	12	February	February	NNP
10_1101-2021_02_13_429885	461	13	13	13	CD
10_1101-2021_02_13_429885	461	14	,	,	,
10_1101-2021_02_13_429885	461	15	2021	2021	CD
10_1101-2021_02_13_429885	461	16	.	.	.
10_1101-2021_02_13_429885	461	17	;	;	:
10_1101-2021_02_13_429885	461	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	461	19	:	:	:
10_1101-2021_02_13_429885	461	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	461	21	preprint	preprint	NN
10_1101-2021_02_13_429885	461	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	461	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	461	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	461	25	et	et	FW
10_1101-2021_02_13_429885	461	26	al	al	NNP
10_1101-2021_02_13_429885	461	27	.	.	.
10_1101-2021_02_13_429885	462	1	A	a	DT
10_1101-2021_02_13_429885	462	2	fully	fully	RB
10_1101-2021_02_13_429885	462	3	automated	automate	VBN
10_1101-2021_02_13_429885	462	4	approach	approach	NN
10_1101-2021_02_13_429885	462	5	for	for	IN
10_1101-2021_02_13_429885	462	6	quality	quality	NN
10_1101-2021_02_13_429885	462	7	control	control	NN
10_1101-2021_02_13_429885	462	8	of	of	IN
10_1101-2021_02_13_429885	462	9	cancer	cancer	NN
10_1101-2021_02_13_429885	462	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	462	11	in	in	IN
10_1101-2021_02_13_429885	462	12	the	the	DT
10_1101-2021_02_13_429885	462	13	era	era	NN
10_1101-2021_02_13_429885	462	14	of	of	IN
10_1101-2021_02_13_429885	462	15	high	high	JJ
10_1101-2021_02_13_429885	462	16	-	-	HYPH
10_1101-2021_02_13_429885	462	17	resolution	resolution	NN
10_1101-2021_02_13_429885	462	18	whole	whole	JJ
10_1101-2021_02_13_429885	462	19	genome	genome	JJ
10_1101-2021_02_13_429885	462	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	462	21	.	.	.
10_1101-2021_02_13_429885	463	1	Figure	figure	NN
10_1101-2021_02_13_429885	463	2	3	3	CD
10_1101-2021_02_13_429885	463	3	.	.	.
10_1101-2021_02_13_429885	463	4	a	a	DT
10_1101-2021_02_13_429885	463	5	-	-	HYPH
10_1101-2021_02_13_429885	463	6	d	d	NN
10_1101-2021_02_13_429885	463	7	.	.	.
10_1101-2021_02_13_429885	464	1	Peak	peak	VB
10_1101-2021_02_13_429885	464	2	detection	detection	NN
10_1101-2021_02_13_429885	464	3	analysis	analysis	NN
10_1101-2021_02_13_429885	464	4	assessing	assess	VBG
10_1101-2021_02_13_429885	464	5	the	the	DT
10_1101-2021_02_13_429885	464	6	quality	quality	NN
10_1101-2021_02_13_429885	464	7	of	of	IN
10_1101-2021_02_13_429885	464	8	CNA	CNA	NNP
10_1101-2021_02_13_429885	464	9	segments	segment	NNS
10_1101-2021_02_13_429885	464	10	(	(	-LRB-
10_1101-2021_02_13_429885	464	11	split	split	VBN
10_1101-2021_02_13_429885	464	12	by	by	IN
10_1101-2021_02_13_429885	464	13	copy	copy	NN
10_1101-2021_02_13_429885	464	14	state	state	NN
10_1101-2021_02_13_429885	464	15	)	)	-RRB-
10_1101-2021_02_13_429885	464	16	,	,	,
10_1101-2021_02_13_429885	464	17	and	and	CC
10_1101-2021_02_13_429885	464	18	tumour	tumour	NN
10_1101-2021_02_13_429885	464	19	purity	purity	NN
10_1101-2021_02_13_429885	464	20	.	.	.
10_1101-2021_02_13_429885	465	1	The	the	DT
10_1101-2021_02_13_429885	465	2	shaded	shaded	JJ
10_1101-2021_02_13_429885	465	3	gray	gray	JJ
10_1101-2021_02_13_429885	465	4	area	area	NN
10_1101-2021_02_13_429885	465	5	are	be	VBP
10_1101-2021_02_13_429885	465	6	input	input	NN
10_1101-2021_02_13_429885	465	7	mutations	mutation	NNS
10_1101-2021_02_13_429885	465	8	,	,	,
10_1101-2021_02_13_429885	465	9	and	and	CC
10_1101-2021_02_13_429885	465	10	the	the	DT
10_1101-2021_02_13_429885	465	11	thin	thin	JJ
10_1101-2021_02_13_429885	465	12	black	black	JJ
10_1101-2021_02_13_429885	465	13	profile	profile	NN
10_1101-2021_02_13_429885	465	14	is	be	VBZ
10_1101-2021_02_13_429885	465	15	its	-PRON-	PRP$
10_1101-2021_02_13_429885	465	16	kernel	kernel	NN
10_1101-2021_02_13_429885	465	17	density	density	NN
10_1101-2021_02_13_429885	465	18	estimation	estimation	NN
10_1101-2021_02_13_429885	465	19	(	(	-LRB-
10_1101-2021_02_13_429885	465	20	KDE	KDE	NNP
10_1101-2021_02_13_429885	465	21	)	)	-RRB-
10_1101-2021_02_13_429885	465	22	.	.	.
10_1101-2021_02_13_429885	466	1	The	the	DT
10_1101-2021_02_13_429885	466	2	black	black	JJ
10_1101-2021_02_13_429885	466	3	circles	circle	NNS
10_1101-2021_02_13_429885	466	4	represent	represent	VBP
10_1101-2021_02_13_429885	466	5	the	the	DT
10_1101-2021_02_13_429885	466	6	peaks	peak	NNS
10_1101-2021_02_13_429885	466	7	detected	detect	VBN
10_1101-2021_02_13_429885	466	8	from	from	IN
10_1101-2021_02_13_429885	466	9	the	the	DT
10_1101-2021_02_13_429885	466	10	KDE	KDE	NNP
10_1101-2021_02_13_429885	466	11	,	,	,
10_1101-2021_02_13_429885	466	12	and	and	CC
10_1101-2021_02_13_429885	466	13	the	the	DT
10_1101-2021_02_13_429885	466	14	vertical	vertical	JJ
10_1101-2021_02_13_429885	466	15	dashed	dash	VBN
10_1101-2021_02_13_429885	466	16	lines	line	NNS
10_1101-2021_02_13_429885	466	17	are	be	VBP
10_1101-2021_02_13_429885	466	18	the	the	DT
10_1101-2021_02_13_429885	466	19	expected	expect	VBN
10_1101-2021_02_13_429885	466	20	peaks	peak	NNS
10_1101-2021_02_13_429885	466	21	,	,	,
10_1101-2021_02_13_429885	466	22	given	give	VBN
10_1101-2021_02_13_429885	466	23	the	the	DT
10_1101-2021_02_13_429885	466	24	tumour	tumour	NN
10_1101-2021_02_13_429885	466	25	purity	purity	NN
10_1101-2021_02_13_429885	466	26	.	.	.
10_1101-2021_02_13_429885	467	1	If	if	IN
10_1101-2021_02_13_429885	467	2	the	the	DT
10_1101-2021_02_13_429885	467	3	data	data	NN
10_1101-2021_02_13_429885	467	4	peaks	peak	NNS
10_1101-2021_02_13_429885	467	5	fall	fall	VBP
10_1101-2021_02_13_429885	467	6	within	within	IN
10_1101-2021_02_13_429885	467	7	the	the	DT
10_1101-2021_02_13_429885	467	8	shaded	shaded	JJ
10_1101-2021_02_13_429885	467	9	area	area	NN
10_1101-2021_02_13_429885	467	10	surrounding	surround	VBG
10_1101-2021_02_13_429885	467	11	the	the	DT
10_1101-2021_02_13_429885	467	12	vertical	vertical	JJ
10_1101-2021_02_13_429885	467	13	line	line	NN
10_1101-2021_02_13_429885	467	14	,	,	,
10_1101-2021_02_13_429885	467	15	the	the	DT
10_1101-2021_02_13_429885	467	16	estimates	estimate	NNS
10_1101-2021_02_13_429885	467	17	are	be	VBP
10_1101-2021_02_13_429885	467	18	consistent	consistent	JJ
10_1101-2021_02_13_429885	467	19	and	and	CC
10_1101-2021_02_13_429885	467	20	the	the	DT
10_1101-2021_02_13_429885	467	21	plot	plot	NN
10_1101-2021_02_13_429885	467	22	is	be	VBZ
10_1101-2021_02_13_429885	467	23	therefore	therefore	RB
10_1101-2021_02_13_429885	467	24	green	green	JJ
10_1101-2021_02_13_429885	467	25	(	(	-LRB-
10_1101-2021_02_13_429885	467	26	QC	QC	NNP
10_1101-2021_02_13_429885	467	27	pass	pass	NN
10_1101-2021_02_13_429885	467	28	)	)	-RRB-
10_1101-2021_02_13_429885	467	29	.	.	.
10_1101-2021_02_13_429885	468	1	For	for	IN
10_1101-2021_02_13_429885	468	2	copy	copy	NN
10_1101-2021_02_13_429885	468	3	states	state	NNS
10_1101-2021_02_13_429885	468	4	with	with	IN
10_1101-2021_02_13_429885	468	5	total	total	JJ
10_1101-2021_02_13_429885	468	6	copy	copy	NN
10_1101-2021_02_13_429885	468	7	number	number	NN
10_1101-2021_02_13_429885	468	8	>	>	NN
10_1101-2021_02_13_429885	468	9	2	2	CD
10_1101-2021_02_13_429885	468	10	,	,	,
10_1101-2021_02_13_429885	468	11	multiple	multiple	JJ
10_1101-2021_02_13_429885	468	12	peaks	peak	NNS
10_1101-2021_02_13_429885	468	13	are	be	VBP
10_1101-2021_02_13_429885	468	14	checked	check	VBN
10_1101-2021_02_13_429885	468	15	independently	independently	RB
10_1101-2021_02_13_429885	468	16	.	.	.
10_1101-2021_02_13_429885	469	1	In	in	IN
10_1101-2021_02_13_429885	469	2	that	that	DT
10_1101-2021_02_13_429885	469	3	case	case	NN
10_1101-2021_02_13_429885	469	4	the	the	DT
10_1101-2021_02_13_429885	469	5	overall	overall	JJ
10_1101-2021_02_13_429885	469	6	QC	QC	NNP
10_1101-2021_02_13_429885	469	7	status	status	NN
10_1101-2021_02_13_429885	469	8	for	for	IN
10_1101-2021_02_13_429885	469	9	the	the	DT
10_1101-2021_02_13_429885	469	10	copy	copy	NN
10_1101-2021_02_13_429885	469	11	state	state	NN
10_1101-2021_02_13_429885	469	12	is	be	VBZ
10_1101-2021_02_13_429885	469	13	a	a	DT
10_1101-2021_02_13_429885	469	14	linear	linear	JJ
10_1101-2021_02_13_429885	469	15	combination	combination	NN
10_1101-2021_02_13_429885	469	16	of	of	IN
10_1101-2021_02_13_429885	469	17	the	the	DT
10_1101-2021_02_13_429885	469	18	results	result	NNS
10_1101-2021_02_13_429885	469	19	,	,	,
10_1101-2021_02_13_429885	469	20	weighted	weight	VBN
10_1101-2021_02_13_429885	469	21	by	by	IN
10_1101-2021_02_13_429885	469	22	the	the	DT
10_1101-2021_02_13_429885	469	23	number	number	NN
10_1101-2021_02_13_429885	469	24	of	of	IN
10_1101-2021_02_13_429885	469	25	mutations	mutation	NNS
10_1101-2021_02_13_429885	469	26	assignable	assignable	JJ
10_1101-2021_02_13_429885	469	27	to	to	IN
10_1101-2021_02_13_429885	469	28	each	each	DT
10_1101-2021_02_13_429885	469	29	peak	peak	NN
10_1101-2021_02_13_429885	469	30	.	.	.
10_1101-2021_02_13_429885	470	1	​e	​e	LS
10_1101-2021_02_13_429885	470	2	-	-	HYPH
10_1101-2021_02_13_429885	470	3	h	h	NN
10_1101-2021_02_13_429885	470	4	.	.	.
10_1101-2021_02_13_429885	470	5	Cancer	Cancer	NNP
10_1101-2021_02_13_429885	470	6	Cell	Cell	NNP
10_1101-2021_02_13_429885	470	7	Fractions	Fractions	NNPS
10_1101-2021_02_13_429885	470	8	(	(	-LRB-
10_1101-2021_02_13_429885	470	9	CCF	CCF	NNP
10_1101-2021_02_13_429885	470	10	)	)	-RRB-
10_1101-2021_02_13_429885	470	11	estimation	estimation	NN
10_1101-2021_02_13_429885	470	12	for	for	IN
10_1101-2021_02_13_429885	470	13	each	each	DT
10_1101-2021_02_13_429885	470	14	tumour	tumour	NN
10_1101-2021_02_13_429885	470	15	genome	genome	NN
10_1101-2021_02_13_429885	470	16	,	,	,
10_1101-2021_02_13_429885	470	17	using	use	VBG
10_1101-2021_02_13_429885	470	18	the	the	DT
10_1101-2021_02_13_429885	470	19	entropy	entropy	JJ
10_1101-2021_02_13_429885	470	20	method	method	NN
10_1101-2021_02_13_429885	470	21	.	.	.
10_1101-2021_02_13_429885	471	1	Each	each	DT
10_1101-2021_02_13_429885	471	2	plot	plot	NN
10_1101-2021_02_13_429885	471	3	shows	show	VBZ
10_1101-2021_02_13_429885	471	4	both	both	DT
10_1101-2021_02_13_429885	471	5	CCF	ccf	NN
10_1101-2021_02_13_429885	471	6	,	,	,
10_1101-2021_02_13_429885	471	7	and	and	CC
10_1101-2021_02_13_429885	471	8	the	the	DT
10_1101-2021_02_13_429885	471	9	VAF	VAF	NNP
10_1101-2021_02_13_429885	471	10	from	from	IN
10_1101-2021_02_13_429885	471	11	which	which	WDT
10_1101-2021_02_13_429885	471	12	mutation	mutation	NN
10_1101-2021_02_13_429885	471	13	multiplicities	multiplicity	NNS
10_1101-2021_02_13_429885	471	14	are	be	VBP
10_1101-2021_02_13_429885	471	15	computed	compute	VBN
10_1101-2021_02_13_429885	471	16	.	.	.
10_1101-2021_02_13_429885	472	1	In	in	IN
10_1101-2021_02_13_429885	472	2	the	the	DT
10_1101-2021_02_13_429885	472	3	rightmost	rightmost	JJ
10_1101-2021_02_13_429885	472	4	panel	panel	NN
10_1101-2021_02_13_429885	472	5	we	-PRON-	PRP
10_1101-2021_02_13_429885	472	6	overlay	overlay	VBP
10_1101-2021_02_13_429885	472	7	the	the	DT
10_1101-2021_02_13_429885	472	8	entropy	entropy	JJ
10_1101-2021_02_13_429885	472	9	profile	profile	NN
10_1101-2021_02_13_429885	472	10	computed	compute	VBN
10_1101-2021_02_13_429885	472	11	by	by	IN
10_1101-2021_02_13_429885	472	12	a	a	DT
10_1101-2021_02_13_429885	472	13	2-dimensional	2-dimensional	CD
10_1101-2021_02_13_429885	472	14	Binomial	Binomial	NNP
10_1101-2021_02_13_429885	472	15	mixture	mixture	NN
10_1101-2021_02_13_429885	472	16	.	.	.
10_1101-2021_02_13_429885	473	1	Areas	area	NNS
10_1101-2021_02_13_429885	473	2	within	within	IN
10_1101-2021_02_13_429885	473	3	the	the	DT
10_1101-2021_02_13_429885	473	4	red	red	JJ
10_1101-2021_02_13_429885	473	5	vertical	vertical	JJ
10_1101-2021_02_13_429885	473	6	dashed	dash	VBN
10_1101-2021_02_13_429885	473	7	lines	line	NNS
10_1101-2021_02_13_429885	473	8	are	be	VBP
10_1101-2021_02_13_429885	473	9	those	those	DT
10_1101-2021_02_13_429885	473	10	for	for	IN
10_1101-2021_02_13_429885	473	11	which	which	WDT
10_1101-2021_02_13_429885	473	12	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	473	13	can	can	MD
10_1101-2021_02_13_429885	473	14	not	not	RB
10_1101-2021_02_13_429885	473	15	assign	assign	VB
10_1101-2021_02_13_429885	473	16	a	a	DT
10_1101-2021_02_13_429885	473	17	confident	confident	JJ
10_1101-2021_02_13_429885	473	18	CCF	ccf	NN
10_1101-2021_02_13_429885	473	19	value	value	NN
10_1101-2021_02_13_429885	473	20	.	.	.
10_1101-2021_02_13_429885	474	1	For	for	IN
10_1101-2021_02_13_429885	474	2	copy	copy	NN
10_1101-2021_02_13_429885	474	3	states	state	NNS
10_1101-2021_02_13_429885	474	4	1:0	1:0	CD
10_1101-2021_02_13_429885	474	5	and	and	CC
10_1101-2021_02_13_429885	474	6	1:1	1:1	CD
10_1101-2021_02_13_429885	474	7	the	the	DT
10_1101-2021_02_13_429885	474	8	mutation	mutation	NN
10_1101-2021_02_13_429885	474	9	multiplicity	multiplicity	NN
10_1101-2021_02_13_429885	474	10	is	be	VBZ
10_1101-2021_02_13_429885	474	11	fixed	fix	VBN
10_1101-2021_02_13_429885	474	12	to	to	IN
10_1101-2021_02_13_429885	474	13	1	1	CD
10_1101-2021_02_13_429885	474	14	by	by	IN
10_1101-2021_02_13_429885	474	15	definition	definition	NN
10_1101-2021_02_13_429885	474	16	.	.	.
10_1101-2021_02_13_429885	475	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	475	2	-	-	:
10_1101-2021_02_13_429885	475	3	BY	by	IN
10_1101-2021_02_13_429885	475	4	-	-	HYPH
10_1101-2021_02_13_429885	475	5	NC	NC	NNP
10_1101-2021_02_13_429885	475	6	-	-	HYPH
10_1101-2021_02_13_429885	475	7	ND	ND	NNP
10_1101-2021_02_13_429885	475	8	4.0	4.0	CD
10_1101-2021_02_13_429885	475	9	International	International	NNP
10_1101-2021_02_13_429885	475	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	475	11	under	under	IN
10_1101-2021_02_13_429885	475	12	a	a	DT
10_1101-2021_02_13_429885	475	13	(	(	-LRB-
10_1101-2021_02_13_429885	475	14	which	which	WDT
10_1101-2021_02_13_429885	475	15	was	be	VBD
10_1101-2021_02_13_429885	475	16	not	not	RB
10_1101-2021_02_13_429885	475	17	certified	certify	VBN
10_1101-2021_02_13_429885	475	18	by	by	IN
10_1101-2021_02_13_429885	475	19	peer	peer	NN
10_1101-2021_02_13_429885	475	20	review	review	NN
10_1101-2021_02_13_429885	475	21	)	)	-RRB-
10_1101-2021_02_13_429885	475	22	is	be	VBZ
10_1101-2021_02_13_429885	475	23	the	the	DT
10_1101-2021_02_13_429885	475	24	author	author	NN
10_1101-2021_02_13_429885	475	25	/	/	SYM
10_1101-2021_02_13_429885	475	26	funder	funder	NN
10_1101-2021_02_13_429885	475	27	,	,	,
10_1101-2021_02_13_429885	475	28	who	who	WP
10_1101-2021_02_13_429885	475	29	has	have	VBZ
10_1101-2021_02_13_429885	475	30	granted	grant	VBN
10_1101-2021_02_13_429885	475	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	475	32	a	a	DT
10_1101-2021_02_13_429885	475	33	license	license	NN
10_1101-2021_02_13_429885	475	34	to	to	TO
10_1101-2021_02_13_429885	475	35	display	display	VB
10_1101-2021_02_13_429885	475	36	the	the	DT
10_1101-2021_02_13_429885	475	37	preprint	preprint	NN
10_1101-2021_02_13_429885	475	38	in	in	IN
10_1101-2021_02_13_429885	475	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	475	40	.	.	.
10_1101-2021_02_13_429885	476	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	476	2	is	be	VBZ
10_1101-2021_02_13_429885	476	3	made	make	VBN
10_1101-2021_02_13_429885	476	4	The	the	DT
10_1101-2021_02_13_429885	476	5	copyright	copyright	NN
10_1101-2021_02_13_429885	476	6	holder	holder	NN
10_1101-2021_02_13_429885	476	7	for	for	IN
10_1101-2021_02_13_429885	476	8	this	this	DT
10_1101-2021_02_13_429885	476	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	476	10	version	version	NN
10_1101-2021_02_13_429885	476	11	posted	post	VBD
10_1101-2021_02_13_429885	476	12	February	February	NNP
10_1101-2021_02_13_429885	476	13	13	13	CD
10_1101-2021_02_13_429885	476	14	,	,	,
10_1101-2021_02_13_429885	476	15	2021	2021	CD
10_1101-2021_02_13_429885	476	16	.	.	.
10_1101-2021_02_13_429885	476	17	;	;	:
10_1101-2021_02_13_429885	476	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	476	19	:	:	:
10_1101-2021_02_13_429885	476	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	476	21	preprint	preprint	NN
10_1101-2021_02_13_429885	476	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	476	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	476	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	476	25	et	et	FW
10_1101-2021_02_13_429885	476	26	al	al	NNP
10_1101-2021_02_13_429885	476	27	.	.	.
10_1101-2021_02_13_429885	477	1	A	a	DT
10_1101-2021_02_13_429885	477	2	fully	fully	RB
10_1101-2021_02_13_429885	477	3	automated	automate	VBN
10_1101-2021_02_13_429885	477	4	approach	approach	NN
10_1101-2021_02_13_429885	477	5	for	for	IN
10_1101-2021_02_13_429885	477	6	quality	quality	NN
10_1101-2021_02_13_429885	477	7	control	control	NN
10_1101-2021_02_13_429885	477	8	of	of	IN
10_1101-2021_02_13_429885	477	9	cancer	cancer	NN
10_1101-2021_02_13_429885	477	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	477	11	in	in	IN
10_1101-2021_02_13_429885	477	12	the	the	DT
10_1101-2021_02_13_429885	477	13	era	era	NN
10_1101-2021_02_13_429885	477	14	of	of	IN
10_1101-2021_02_13_429885	477	15	high	high	JJ
10_1101-2021_02_13_429885	477	16	-	-	HYPH
10_1101-2021_02_13_429885	477	17	resolution	resolution	NN
10_1101-2021_02_13_429885	477	18	whole	whole	JJ
10_1101-2021_02_13_429885	477	19	genome	genome	JJ
10_1101-2021_02_13_429885	477	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	477	21	.	.	.
10_1101-2021_02_13_429885	478	1	Figure	figure	NN
10_1101-2021_02_13_429885	478	2	4	4	CD
10_1101-2021_02_13_429885	478	3	.	.	.
10_1101-2021_02_13_429885	478	4	a.	a.	NN
10_1101-2021_02_13_429885	478	5	Circos	Circos	NNP
10_1101-2021_02_13_429885	478	6	plot	plot	NN
10_1101-2021_02_13_429885	478	7	for	for	IN
10_1101-2021_02_13_429885	478	8	four	four	CD
10_1101-2021_02_13_429885	478	9	possible	possible	JJ
10_1101-2021_02_13_429885	478	10	whole	whole	RB
10_1101-2021_02_13_429885	478	11	-	-	HYPH
10_1101-2021_02_13_429885	478	12	genome	genome	JJ
10_1101-2021_02_13_429885	478	13	CNA	cna	NN
10_1101-2021_02_13_429885	478	14	segmentations	segmentation	NNS
10_1101-2021_02_13_429885	478	15	determined	determine	VBN
10_1101-2021_02_13_429885	478	16	by	by	IN
10_1101-2021_02_13_429885	478	17	Sequenza	Sequenza	NNP
10_1101-2021_02_13_429885	478	18	with	with	IN
10_1101-2021_02_13_429885	478	19	WGS	WGS	NNP
10_1101-2021_02_13_429885	478	20	data	datum	NNS
10_1101-2021_02_13_429885	478	21	(	(	-LRB-
10_1101-2021_02_13_429885	478	22	~80x	~80x	NFP
10_1101-2021_02_13_429885	478	23	median	median	JJ
10_1101-2021_02_13_429885	478	24	coverage	coverage	NN
10_1101-2021_02_13_429885	478	25	,	,	,
10_1101-2021_02_13_429885	478	26	purity	purity	NN
10_1101-2021_02_13_429885	478	27	87	87	CD
10_1101-2021_02_13_429885	478	28	%	%	NN
10_1101-2021_02_13_429885	478	29	)	)	-RRB-
10_1101-2021_02_13_429885	478	30	.	.	.
10_1101-2021_02_13_429885	479	1	The	the	DT
10_1101-2021_02_13_429885	479	2	input	input	NN
10_1101-2021_02_13_429885	479	3	sample	sample	NN
10_1101-2021_02_13_429885	479	4	is	be	VBZ
10_1101-2021_02_13_429885	479	5	Set7_57	Set7_57	NNP
10_1101-2021_02_13_429885	479	6	,	,	,
10_1101-2021_02_13_429885	479	7	one	one	CD
10_1101-2021_02_13_429885	479	8	of	of	IN
10_1101-2021_02_13_429885	479	9	four	four	CD
10_1101-2021_02_13_429885	479	10	multi	multi	JJ
10_1101-2021_02_13_429885	479	11	-	-	JJ
10_1101-2021_02_13_429885	479	12	region	region	JJ
10_1101-2021_02_13_429885	479	13	biopsies	biopsy	NNS
10_1101-2021_02_13_429885	479	14	for	for	IN
10_1101-2021_02_13_429885	479	15	colorectal	colorectal	JJ
10_1101-2021_02_13_429885	479	16	cancer	cancer	NN
10_1101-2021_02_13_429885	479	17	patient	patient	NN
10_1101-2021_02_13_429885	479	18	Set7	Set7	NNP
10_1101-2021_02_13_429885	479	19	.	.	.
10_1101-2021_02_13_429885	480	1	The	the	DT
10_1101-2021_02_13_429885	480	2	first	first	JJ
10_1101-2021_02_13_429885	480	3	run	run	NN
10_1101-2021_02_13_429885	480	4	is	be	VBZ
10_1101-2021_02_13_429885	480	5	with	with	IN
10_1101-2021_02_13_429885	480	6	default	default	JJ
10_1101-2021_02_13_429885	480	7	Sequenza	Sequenza	NNP
10_1101-2021_02_13_429885	480	8	parameters	parameter	NNS
10_1101-2021_02_13_429885	480	9	.	.	.
10_1101-2021_02_13_429885	481	1	With	with	IN
10_1101-2021_02_13_429885	481	2	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	481	3	,	,	,
10_1101-2021_02_13_429885	481	4	we	-PRON-	PRP
10_1101-2021_02_13_429885	481	5	slightly	slightly	RB
10_1101-2021_02_13_429885	481	6	adjust	adjust	VBP
10_1101-2021_02_13_429885	481	7	purity	purity	NN
10_1101-2021_02_13_429885	481	8	estimation	estimation	NN
10_1101-2021_02_13_429885	481	9	and	and	CC
10_1101-2021_02_13_429885	481	10	obtain	obtain	VB
10_1101-2021_02_13_429885	481	11	a	a	DT
10_1101-2021_02_13_429885	481	12	final	final	JJ
10_1101-2021_02_13_429885	481	13	run	run	NN
10_1101-2021_02_13_429885	481	14	of	of	IN
10_1101-2021_02_13_429885	481	15	the	the	DT
10_1101-2021_02_13_429885	481	16	tool	tool	NN
10_1101-2021_02_13_429885	481	17	.	.	.
10_1101-2021_02_13_429885	482	1	We	-PRON-	PRP
10_1101-2021_02_13_429885	482	2	also	also	RB
10_1101-2021_02_13_429885	482	3	one	one	CD
10_1101-2021_02_13_429885	482	4	run	run	NN
10_1101-2021_02_13_429885	482	5	forcing	force	VBG
10_1101-2021_02_13_429885	482	6	overall	overall	JJ
10_1101-2021_02_13_429885	482	7	tumour	tumour	NN
10_1101-2021_02_13_429885	482	8	ploidy	ploidy	NN
10_1101-2021_02_13_429885	482	9	to	to	IN
10_1101-2021_02_13_429885	482	10	4	4	CD
10_1101-2021_02_13_429885	482	11	(	(	-LRB-
10_1101-2021_02_13_429885	482	12	tetraploid	tetraploid	NN
10_1101-2021_02_13_429885	482	13	)	)	-RRB-
10_1101-2021_02_13_429885	482	14	,	,	,
10_1101-2021_02_13_429885	482	15	and	and	CC
10_1101-2021_02_13_429885	482	16	one	one	CD
10_1101-2021_02_13_429885	482	17	with	with	IN
10_1101-2021_02_13_429885	482	18	maximum	maximum	JJ
10_1101-2021_02_13_429885	482	19	tumour	tumour	NN
10_1101-2021_02_13_429885	482	20	purity	purity	NN
10_1101-2021_02_13_429885	482	21	60	60	CD
10_1101-2021_02_13_429885	482	22	%	%	NN
10_1101-2021_02_13_429885	482	23	.	.	.
10_1101-2021_02_13_429885	483	1	​b	​b	NNP
10_1101-2021_02_13_429885	483	2	.	.	.
10_1101-2021_02_13_429885	484	1	Purity	purity	NN
10_1101-2021_02_13_429885	484	2	and	and	CC
10_1101-2021_02_13_429885	484	3	ploidy	ploidy	NN
10_1101-2021_02_13_429885	484	4	estimation	estimation	NN
10_1101-2021_02_13_429885	484	5	for	for	IN
10_1101-2021_02_13_429885	484	6	the	the	DT
10_1101-2021_02_13_429885	484	7	four	four	CD
10_1101-2021_02_13_429885	484	8	Sequenza	Sequenza	NNP
10_1101-2021_02_13_429885	484	9	runs	run	NNS
10_1101-2021_02_13_429885	484	10	.	.	.
10_1101-2021_02_13_429885	485	1	Arrows	arrow	NNS
10_1101-2021_02_13_429885	485	2	show	show	VBP
10_1101-2021_02_13_429885	485	3	the	the	DT
10_1101-2021_02_13_429885	485	4	adjustment	adjustment	NN
10_1101-2021_02_13_429885	485	5	proposed	propose	VBN
10_1101-2021_02_13_429885	485	6	by	by	IN
10_1101-2021_02_13_429885	485	7	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	485	8	,	,	,
10_1101-2021_02_13_429885	485	9	the	the	DT
10_1101-2021_02_13_429885	485	10	default	default	NN
10_1101-2021_02_13_429885	485	11	and	and	CC
10_1101-2021_02_13_429885	485	12	final	final	JJ
10_1101-2021_02_13_429885	485	13	runs	run	NNS
10_1101-2021_02_13_429885	485	14	are	be	VBP
10_1101-2021_02_13_429885	485	15	the	the	DT
10_1101-2021_02_13_429885	485	16	only	only	JJ
10_1101-2021_02_13_429885	485	17	ones	one	NNS
10_1101-2021_02_13_429885	485	18	to	to	TO
10_1101-2021_02_13_429885	485	19	pass	pass	VB
10_1101-2021_02_13_429885	485	20	QC	qc	NN
10_1101-2021_02_13_429885	485	21	.	.	.
10_1101-2021_02_13_429885	486	1	​c	​c	NNP
10_1101-2021_02_13_429885	486	2	.	.	.
10_1101-2021_02_13_429885	487	1	Final	final	JJ
10_1101-2021_02_13_429885	487	2	run	run	NN
10_1101-2021_02_13_429885	487	3	with	with	IN
10_1101-2021_02_13_429885	487	4	perfect	perfect	JJ
10_1101-2021_02_13_429885	487	5	results	result	NNS
10_1101-2021_02_13_429885	487	6	for	for	IN
10_1101-2021_02_13_429885	487	7	Set7_57	Set7_57	NNP
10_1101-2021_02_13_429885	487	8	:	:	:
10_1101-2021_02_13_429885	487	9	copy	copy	NN
10_1101-2021_02_13_429885	487	10	number	number	NN
10_1101-2021_02_13_429885	487	11	segments	segment	NNS
10_1101-2021_02_13_429885	487	12	,	,	,
10_1101-2021_02_13_429885	487	13	depth	depth	NN
10_1101-2021_02_13_429885	487	14	of	of	IN
10_1101-2021_02_13_429885	487	15	coverage	coverage	NN
10_1101-2021_02_13_429885	487	16	per	per	IN
10_1101-2021_02_13_429885	487	17	mutation	mutation	NN
10_1101-2021_02_13_429885	487	18	and	and	CC
10_1101-2021_02_13_429885	487	19	mutation	mutation	NN
10_1101-2021_02_13_429885	487	20	density	density	NN
10_1101-2021_02_13_429885	487	21	per	per	IN
10_1101-2021_02_13_429885	487	22	megabase	megabase	NN
10_1101-2021_02_13_429885	487	23	.	.	.
10_1101-2021_02_13_429885	488	1	​d	​d	LS
10_1101-2021_02_13_429885	488	2	.	.	.
10_1101-2021_02_13_429885	489	1	​Miscalled	​miscalle	VBN
10_1101-2021_02_13_429885	489	2	copy	copy	NN
10_1101-2021_02_13_429885	489	3	-	-	HYPH
10_1101-2021_02_13_429885	489	4	neutral	neutral	JJ
10_1101-2021_02_13_429885	489	5	LOH	LOH	NNP
10_1101-2021_02_13_429885	489	6	segment	segment	NN
10_1101-2021_02_13_429885	489	7	,	,	,
10_1101-2021_02_13_429885	489	8	obtained	obtain	VBN
10_1101-2021_02_13_429885	489	9	by	by	IN
10_1101-2021_02_13_429885	489	10	forcing	force	VBG
10_1101-2021_02_13_429885	489	11	a	a	DT
10_1101-2021_02_13_429885	489	12	tetraploid	tetraploid	NN
10_1101-2021_02_13_429885	489	13	solution	solution	NN
10_1101-2021_02_13_429885	489	14	in	in	IN
10_1101-2021_02_13_429885	489	15	Sequenza	Sequenza	NNP
10_1101-2021_02_13_429885	489	16	.	.	.
10_1101-2021_02_13_429885	490	1	For	for	IN
10_1101-2021_02_13_429885	490	2	a	a	DT
10_1101-2021_02_13_429885	490	3	2:0	2:0	CD
10_1101-2021_02_13_429885	490	4	segment	segment	NN
10_1101-2021_02_13_429885	490	5	with	with	IN
10_1101-2021_02_13_429885	490	6	the	the	DT
10_1101-2021_02_13_429885	490	7	estimated	estimate	VBN
10_1101-2021_02_13_429885	490	8	Sequenza	Sequenza	NNP
10_1101-2021_02_13_429885	490	9	.CC	.CC	:
10_1101-2021_02_13_429885	490	10	-	-	:
10_1101-2021_02_13_429885	490	11	BY	by	IN
10_1101-2021_02_13_429885	490	12	-	-	HYPH
10_1101-2021_02_13_429885	490	13	NC	NC	NNP
10_1101-2021_02_13_429885	490	14	-	-	HYPH
10_1101-2021_02_13_429885	490	15	ND	ND	NNP
10_1101-2021_02_13_429885	490	16	4.0	4.0	CD
10_1101-2021_02_13_429885	490	17	International	International	NNP
10_1101-2021_02_13_429885	490	18	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	490	19	under	under	IN
10_1101-2021_02_13_429885	490	20	a	a	DT
10_1101-2021_02_13_429885	490	21	(	(	-LRB-
10_1101-2021_02_13_429885	490	22	which	which	WDT
10_1101-2021_02_13_429885	490	23	was	be	VBD
10_1101-2021_02_13_429885	490	24	not	not	RB
10_1101-2021_02_13_429885	490	25	certified	certify	VBN
10_1101-2021_02_13_429885	490	26	by	by	IN
10_1101-2021_02_13_429885	490	27	peer	peer	NN
10_1101-2021_02_13_429885	490	28	review	review	NN
10_1101-2021_02_13_429885	490	29	)	)	-RRB-
10_1101-2021_02_13_429885	490	30	is	be	VBZ
10_1101-2021_02_13_429885	490	31	the	the	DT
10_1101-2021_02_13_429885	490	32	author	author	NN
10_1101-2021_02_13_429885	490	33	/	/	SYM
10_1101-2021_02_13_429885	490	34	funder	funder	NN
10_1101-2021_02_13_429885	490	35	,	,	,
10_1101-2021_02_13_429885	490	36	who	who	WP
10_1101-2021_02_13_429885	490	37	has	have	VBZ
10_1101-2021_02_13_429885	490	38	granted	grant	VBN
10_1101-2021_02_13_429885	490	39	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	490	40	a	a	DT
10_1101-2021_02_13_429885	490	41	license	license	NN
10_1101-2021_02_13_429885	490	42	to	to	TO
10_1101-2021_02_13_429885	490	43	display	display	VB
10_1101-2021_02_13_429885	490	44	the	the	DT
10_1101-2021_02_13_429885	490	45	preprint	preprint	NN
10_1101-2021_02_13_429885	490	46	in	in	IN
10_1101-2021_02_13_429885	490	47	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	490	48	.	.	.
10_1101-2021_02_13_429885	491	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	491	2	is	be	VBZ
10_1101-2021_02_13_429885	491	3	made	make	VBN
10_1101-2021_02_13_429885	491	4	The	the	DT
10_1101-2021_02_13_429885	491	5	copyright	copyright	NN
10_1101-2021_02_13_429885	491	6	holder	holder	NN
10_1101-2021_02_13_429885	491	7	for	for	IN
10_1101-2021_02_13_429885	491	8	this	this	DT
10_1101-2021_02_13_429885	491	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	491	10	version	version	NN
10_1101-2021_02_13_429885	491	11	posted	post	VBD
10_1101-2021_02_13_429885	491	12	February	February	NNP
10_1101-2021_02_13_429885	491	13	13	13	CD
10_1101-2021_02_13_429885	491	14	,	,	,
10_1101-2021_02_13_429885	491	15	2021	2021	CD
10_1101-2021_02_13_429885	491	16	.	.	.
10_1101-2021_02_13_429885	491	17	;	;	:
10_1101-2021_02_13_429885	491	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	491	19	:	:	:
10_1101-2021_02_13_429885	491	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	491	21	preprint	preprint	NN
10_1101-2021_02_13_429885	491	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	491	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	491	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	491	25	et	et	FW
10_1101-2021_02_13_429885	491	26	al	al	NNP
10_1101-2021_02_13_429885	491	27	.	.	.
10_1101-2021_02_13_429885	492	1	A	a	DT
10_1101-2021_02_13_429885	492	2	fully	fully	RB
10_1101-2021_02_13_429885	492	3	automated	automate	VBN
10_1101-2021_02_13_429885	492	4	approach	approach	NN
10_1101-2021_02_13_429885	492	5	for	for	IN
10_1101-2021_02_13_429885	492	6	quality	quality	NN
10_1101-2021_02_13_429885	492	7	control	control	NN
10_1101-2021_02_13_429885	492	8	of	of	IN
10_1101-2021_02_13_429885	492	9	cancer	cancer	NN
10_1101-2021_02_13_429885	492	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	492	11	in	in	IN
10_1101-2021_02_13_429885	492	12	the	the	DT
10_1101-2021_02_13_429885	492	13	era	era	NN
10_1101-2021_02_13_429885	492	14	of	of	IN
10_1101-2021_02_13_429885	492	15	high	high	JJ
10_1101-2021_02_13_429885	492	16	-	-	HYPH
10_1101-2021_02_13_429885	492	17	resolution	resolution	NN
10_1101-2021_02_13_429885	492	18	whole	whole	JJ
10_1101-2021_02_13_429885	492	19	genome	genome	JJ
10_1101-2021_02_13_429885	492	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	492	21	.	.	.
10_1101-2021_02_13_429885	493	1	purity	purity	NN
10_1101-2021_02_13_429885	493	2	we	-PRON-	PRP
10_1101-2021_02_13_429885	493	3	expected	expect	VBD
10_1101-2021_02_13_429885	493	4	peaks	peak	NNS
10_1101-2021_02_13_429885	493	5	at	at	IN
10_1101-2021_02_13_429885	493	6	~60	~60	NFP
10_1101-2021_02_13_429885	493	7	%	%	NN
10_1101-2021_02_13_429885	493	8	and	and	CC
10_1101-2021_02_13_429885	493	9	~30	~30	:
10_1101-2021_02_13_429885	493	10	%	%	NN
10_1101-2021_02_13_429885	493	11	VAF	VAF	NNP
10_1101-2021_02_13_429885	493	12	,	,	,
10_1101-2021_02_13_429885	493	13	which	which	WDT
10_1101-2021_02_13_429885	493	14	can	can	MD
10_1101-2021_02_13_429885	493	15	not	not	RB
10_1101-2021_02_13_429885	493	16	be	be	VB
10_1101-2021_02_13_429885	493	17	matched	match	VBN
10_1101-2021_02_13_429885	493	18	.	.	.
10_1101-2021_02_13_429885	494	1	​e	​e	LS
10_1101-2021_02_13_429885	494	2	.	.	.
10_1101-2021_02_13_429885	495	1	CNA	CNA	NNP
10_1101-2021_02_13_429885	495	2	calling	call	VBG
10_1101-2021_02_13_429885	495	3	with	with	IN
10_1101-2021_02_13_429885	495	4	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	495	5	and	and	CC
10_1101-2021_02_13_429885	495	6	Sequenza	Sequenza	NNP
10_1101-2021_02_13_429885	495	7	for	for	IN
10_1101-2021_02_13_429885	495	8	4	4	CD
10_1101-2021_02_13_429885	495	9	WGS	WGS	NNP
10_1101-2021_02_13_429885	495	10	biopsies	biopsy	NNS
10_1101-2021_02_13_429885	495	11	of	of	IN
10_1101-2021_02_13_429885	495	12	the	the	DT
10_1101-2021_02_13_429885	495	13	primary	primary	JJ
10_1101-2021_02_13_429885	495	14	colorectal	colorectal	JJ
10_1101-2021_02_13_429885	495	15	cancer	cancer	NN
10_1101-2021_02_13_429885	495	16	Set7	Set7	NNP
10_1101-2021_02_13_429885	495	17	.	.	.
10_1101-2021_02_13_429885	496	1	Figure	figure	NN
10_1101-2021_02_13_429885	496	2	5	5	CD
10_1101-2021_02_13_429885	496	3	.	.	.
10_1101-2021_02_13_429885	496	4	a.	a.	NN
10_1101-2021_02_13_429885	497	1	Summary	Summary	NNP
10_1101-2021_02_13_429885	497	2	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	497	3	pass	pass	VBP
10_1101-2021_02_13_429885	497	4	or	or	CC
10_1101-2021_02_13_429885	497	5	fail	fail	VBP
10_1101-2021_02_13_429885	497	6	barplot	barplot	NN
10_1101-2021_02_13_429885	497	7	for	for	IN
10_1101-2021_02_13_429885	497	8	top	top	JJ
10_1101-2021_02_13_429885	497	9	-	-	HYPH
10_1101-2021_02_13_429885	497	10	quality	quality	NN
10_1101-2021_02_13_429885	497	11	PCAWG	PCAWG	NNP
10_1101-2021_02_13_429885	497	12	samples	sample	NNS
10_1101-2021_02_13_429885	497	13	065	065	CD
10_1101-2021_02_13_429885	497	14	n	n	CC
10_1101-2021_02_13_429885	497	15	=	=	SYM
10_1101-2021_02_13_429885	497	16	1	1	CD
10_1101-2021_02_13_429885	497	17	across	across	IN
10_1101-2021_02_13_429885	497	18	distinct	distinct	JJ
10_1101-2021_02_13_429885	497	19	tumour	tumour	NN
10_1101-2021_02_13_429885	497	20	types	type	NNS
10_1101-2021_02_13_429885	497	21	.	.	.
10_1101-2021_02_13_429885	498	1	Failures	failure	NNS
10_1101-2021_02_13_429885	498	2	for	for	IN
10_1101-2021_02_13_429885	498	3	peaks	peak	NNS
10_1101-2021_02_13_429885	498	4	are	be	VBP
10_1101-2021_02_13_429885	498	5	with	with	IN
10_1101-2021_02_13_429885	498	6	a	a	DT
10_1101-2021_02_13_429885	498	7	3	3	CD
10_1101-2021_02_13_429885	498	8	%	%	NN
10_1101-2021_02_13_429885	498	9	error	error	NN
10_1101-2021_02_13_429885	498	10	tolerance	tolerance	NN
10_1101-2021_02_13_429885	498	11	,	,	,
10_1101-2021_02_13_429885	498	12	and	and	CC
10_1101-2021_02_13_429885	498	13	CCFs	ccf	NNS
10_1101-2021_02_13_429885	498	14	with	with	IN
10_1101-2021_02_13_429885	498	15	10	10	CD
10_1101-2021_02_13_429885	498	16	%	%	NN
10_1101-2021_02_13_429885	498	17	of	of	IN
10_1101-2021_02_13_429885	498	18	SNVs	SNVs	NNPS
10_1101-2021_02_13_429885	498	19	not	not	RB
10_1101-2021_02_13_429885	498	20	assignable	assignable	JJ
10_1101-2021_02_13_429885	498	21	,	,	,
10_1101-2021_02_13_429885	498	22	per	per	IN
10_1101-2021_02_13_429885	498	23	copy	copy	NN
10_1101-2021_02_13_429885	498	24	state	state	NN
10_1101-2021_02_13_429885	498	25	.	.	.
10_1101-2021_02_13_429885	499	1	​b	​b	NNP
10_1101-2021_02_13_429885	499	2	.	.	.
10_1101-2021_02_13_429885	500	1	​Zoom	​Zoom	NNP
10_1101-2021_02_13_429885	500	2	peak	peak	VBP
10_1101-2021_02_13_429885	500	3	analysis	analysis	NN
10_1101-2021_02_13_429885	500	4	with	with	IN
10_1101-2021_02_13_429885	500	5	a	a	DT
10_1101-2021_02_13_429885	500	6	scatter	scatter	NN
10_1101-2021_02_13_429885	500	7	showing	showing	NN
10_1101-2021_02_13_429885	500	8	,	,	,
10_1101-2021_02_13_429885	500	9	for	for	IN
10_1101-2021_02_13_429885	500	10	.CC	.CC	NFP
10_1101-2021_02_13_429885	500	11	-	-	HYPH
10_1101-2021_02_13_429885	500	12	BY	by	IN
10_1101-2021_02_13_429885	500	13	-	-	HYPH
10_1101-2021_02_13_429885	500	14	NC	NC	NNP
10_1101-2021_02_13_429885	500	15	-	-	HYPH
10_1101-2021_02_13_429885	500	16	ND	ND	NNP
10_1101-2021_02_13_429885	500	17	4.0	4.0	CD
10_1101-2021_02_13_429885	500	18	International	International	NNP
10_1101-2021_02_13_429885	500	19	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	500	20	under	under	IN
10_1101-2021_02_13_429885	500	21	a	a	DT
10_1101-2021_02_13_429885	500	22	(	(	-LRB-
10_1101-2021_02_13_429885	500	23	which	which	WDT
10_1101-2021_02_13_429885	500	24	was	be	VBD
10_1101-2021_02_13_429885	500	25	not	not	RB
10_1101-2021_02_13_429885	500	26	certified	certify	VBN
10_1101-2021_02_13_429885	500	27	by	by	IN
10_1101-2021_02_13_429885	500	28	peer	peer	NN
10_1101-2021_02_13_429885	500	29	review	review	NN
10_1101-2021_02_13_429885	500	30	)	)	-RRB-
10_1101-2021_02_13_429885	500	31	is	be	VBZ
10_1101-2021_02_13_429885	500	32	the	the	DT
10_1101-2021_02_13_429885	500	33	author	author	NN
10_1101-2021_02_13_429885	500	34	/	/	SYM
10_1101-2021_02_13_429885	500	35	funder	funder	NN
10_1101-2021_02_13_429885	500	36	,	,	,
10_1101-2021_02_13_429885	500	37	who	who	WP
10_1101-2021_02_13_429885	500	38	has	have	VBZ
10_1101-2021_02_13_429885	500	39	granted	grant	VBN
10_1101-2021_02_13_429885	500	40	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	500	41	a	a	DT
10_1101-2021_02_13_429885	500	42	license	license	NN
10_1101-2021_02_13_429885	500	43	to	to	TO
10_1101-2021_02_13_429885	500	44	display	display	VB
10_1101-2021_02_13_429885	500	45	the	the	DT
10_1101-2021_02_13_429885	500	46	preprint	preprint	NN
10_1101-2021_02_13_429885	500	47	in	in	IN
10_1101-2021_02_13_429885	500	48	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	500	49	.	.	.
10_1101-2021_02_13_429885	501	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	501	2	is	be	VBZ
10_1101-2021_02_13_429885	501	3	made	make	VBN
10_1101-2021_02_13_429885	501	4	The	the	DT
10_1101-2021_02_13_429885	501	5	copyright	copyright	NN
10_1101-2021_02_13_429885	501	6	holder	holder	NN
10_1101-2021_02_13_429885	501	7	for	for	IN
10_1101-2021_02_13_429885	501	8	this	this	DT
10_1101-2021_02_13_429885	501	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	501	10	version	version	NN
10_1101-2021_02_13_429885	501	11	posted	post	VBD
10_1101-2021_02_13_429885	501	12	February	February	NNP
10_1101-2021_02_13_429885	501	13	13	13	CD
10_1101-2021_02_13_429885	501	14	,	,	,
10_1101-2021_02_13_429885	501	15	2021	2021	CD
10_1101-2021_02_13_429885	501	16	.	.	.
10_1101-2021_02_13_429885	501	17	;	;	:
10_1101-2021_02_13_429885	501	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	501	19	:	:	:
10_1101-2021_02_13_429885	501	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	501	21	preprint	preprint	NN
10_1101-2021_02_13_429885	501	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	501	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	501	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	501	25	et	et	FW
10_1101-2021_02_13_429885	501	26	al	al	NNP
10_1101-2021_02_13_429885	501	27	.	.	.
10_1101-2021_02_13_429885	502	1	A	a	DT
10_1101-2021_02_13_429885	502	2	fully	fully	RB
10_1101-2021_02_13_429885	502	3	automated	automate	VBN
10_1101-2021_02_13_429885	502	4	approach	approach	NN
10_1101-2021_02_13_429885	502	5	for	for	IN
10_1101-2021_02_13_429885	502	6	quality	quality	NN
10_1101-2021_02_13_429885	502	7	control	control	NN
10_1101-2021_02_13_429885	502	8	of	of	IN
10_1101-2021_02_13_429885	502	9	cancer	cancer	NN
10_1101-2021_02_13_429885	502	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	502	11	in	in	IN
10_1101-2021_02_13_429885	502	12	the	the	DT
10_1101-2021_02_13_429885	502	13	era	era	NN
10_1101-2021_02_13_429885	502	14	of	of	IN
10_1101-2021_02_13_429885	502	15	high	high	JJ
10_1101-2021_02_13_429885	502	16	-	-	HYPH
10_1101-2021_02_13_429885	502	17	resolution	resolution	NN
10_1101-2021_02_13_429885	502	18	whole	whole	JJ
10_1101-2021_02_13_429885	502	19	genome	genome	JJ
10_1101-2021_02_13_429885	502	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	502	21	.	.	.
10_1101-2021_02_13_429885	503	1	every	every	DT
10_1101-2021_02_13_429885	503	2	tumour	tumour	NN
10_1101-2021_02_13_429885	503	3	type	type	NN
10_1101-2021_02_13_429885	503	4	,	,	,
10_1101-2021_02_13_429885	503	5	the	the	DT
10_1101-2021_02_13_429885	503	6	total	total	JJ
10_1101-2021_02_13_429885	503	7	cases	case	NNS
10_1101-2021_02_13_429885	503	8	per	per	IN
10_1101-2021_02_13_429885	503	9	tumour	tumour	NN
10_1101-2021_02_13_429885	503	10	against	against	IN
10_1101-2021_02_13_429885	503	11	the	the	DT
10_1101-2021_02_13_429885	503	12	proportion	proportion	NN
10_1101-2021_02_13_429885	503	13	of	of	IN
10_1101-2021_02_13_429885	503	14	pass	pass	NN
10_1101-2021_02_13_429885	503	15	or	or	CC
10_1101-2021_02_13_429885	503	16	fails	fail	VBZ
10_1101-2021_02_13_429885	503	17	;	;	:
10_1101-2021_02_13_429885	503	18	each	each	DT
10_1101-2021_02_13_429885	503	19	dot	dot	NN
10_1101-2021_02_13_429885	503	20	size	size	NN
10_1101-2021_02_13_429885	503	21	is	be	VBZ
10_1101-2021_02_13_429885	503	22	proportional	proportional	JJ
10_1101-2021_02_13_429885	503	23	to	to	IN
10_1101-2021_02_13_429885	503	24	the	the	DT
10_1101-2021_02_13_429885	503	25	error	error	NN
10_1101-2021_02_13_429885	503	26	measure	measure	NN
10_1101-2021_02_13_429885	503	27	from	from	IN
10_1101-2021_02_13_429885	503	28	mismatched	mismatch	VBN
10_1101-2021_02_13_429885	503	29	peaks	peak	NNS
10_1101-2021_02_13_429885	503	30	.	.	.
10_1101-2021_02_13_429885	504	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	504	2	-	-	:
10_1101-2021_02_13_429885	504	3	BY	by	IN
10_1101-2021_02_13_429885	504	4	-	-	HYPH
10_1101-2021_02_13_429885	504	5	NC	NC	NNP
10_1101-2021_02_13_429885	504	6	-	-	HYPH
10_1101-2021_02_13_429885	504	7	ND	ND	NNP
10_1101-2021_02_13_429885	504	8	4.0	4.0	CD
10_1101-2021_02_13_429885	504	9	International	International	NNP
10_1101-2021_02_13_429885	504	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	504	11	under	under	IN
10_1101-2021_02_13_429885	504	12	a	a	DT
10_1101-2021_02_13_429885	504	13	(	(	-LRB-
10_1101-2021_02_13_429885	504	14	which	which	WDT
10_1101-2021_02_13_429885	504	15	was	be	VBD
10_1101-2021_02_13_429885	504	16	not	not	RB
10_1101-2021_02_13_429885	504	17	certified	certify	VBN
10_1101-2021_02_13_429885	504	18	by	by	IN
10_1101-2021_02_13_429885	504	19	peer	peer	NN
10_1101-2021_02_13_429885	504	20	review	review	NN
10_1101-2021_02_13_429885	504	21	)	)	-RRB-
10_1101-2021_02_13_429885	504	22	is	be	VBZ
10_1101-2021_02_13_429885	504	23	the	the	DT
10_1101-2021_02_13_429885	504	24	author	author	NN
10_1101-2021_02_13_429885	504	25	/	/	SYM
10_1101-2021_02_13_429885	504	26	funder	funder	NN
10_1101-2021_02_13_429885	504	27	,	,	,
10_1101-2021_02_13_429885	504	28	who	who	WP
10_1101-2021_02_13_429885	504	29	has	have	VBZ
10_1101-2021_02_13_429885	504	30	granted	grant	VBN
10_1101-2021_02_13_429885	504	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	504	32	a	a	DT
10_1101-2021_02_13_429885	504	33	license	license	NN
10_1101-2021_02_13_429885	504	34	to	to	TO
10_1101-2021_02_13_429885	504	35	display	display	VB
10_1101-2021_02_13_429885	504	36	the	the	DT
10_1101-2021_02_13_429885	504	37	preprint	preprint	NN
10_1101-2021_02_13_429885	504	38	in	in	IN
10_1101-2021_02_13_429885	504	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	504	40	.	.	.
10_1101-2021_02_13_429885	505	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	505	2	is	be	VBZ
10_1101-2021_02_13_429885	505	3	made	make	VBN
10_1101-2021_02_13_429885	505	4	The	the	DT
10_1101-2021_02_13_429885	505	5	copyright	copyright	NN
10_1101-2021_02_13_429885	505	6	holder	holder	NN
10_1101-2021_02_13_429885	505	7	for	for	IN
10_1101-2021_02_13_429885	505	8	this	this	DT
10_1101-2021_02_13_429885	505	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	505	10	version	version	NN
10_1101-2021_02_13_429885	505	11	posted	post	VBD
10_1101-2021_02_13_429885	505	12	February	February	NNP
10_1101-2021_02_13_429885	505	13	13	13	CD
10_1101-2021_02_13_429885	505	14	,	,	,
10_1101-2021_02_13_429885	505	15	2021	2021	CD
10_1101-2021_02_13_429885	505	16	.	.	.
10_1101-2021_02_13_429885	505	17	;	;	:
10_1101-2021_02_13_429885	505	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	505	19	:	:	:
10_1101-2021_02_13_429885	505	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	505	21	preprint	preprint	NN
10_1101-2021_02_13_429885	505	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	505	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	505	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	505	25	et	et	FW
10_1101-2021_02_13_429885	505	26	al	al	NNP
10_1101-2021_02_13_429885	505	27	.	.	.
10_1101-2021_02_13_429885	506	1	A	a	DT
10_1101-2021_02_13_429885	506	2	fully	fully	RB
10_1101-2021_02_13_429885	506	3	automated	automate	VBN
10_1101-2021_02_13_429885	506	4	approach	approach	NN
10_1101-2021_02_13_429885	506	5	for	for	IN
10_1101-2021_02_13_429885	506	6	quality	quality	NN
10_1101-2021_02_13_429885	506	7	control	control	NN
10_1101-2021_02_13_429885	506	8	of	of	IN
10_1101-2021_02_13_429885	506	9	cancer	cancer	NN
10_1101-2021_02_13_429885	506	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	506	11	in	in	IN
10_1101-2021_02_13_429885	506	12	the	the	DT
10_1101-2021_02_13_429885	506	13	era	era	NN
10_1101-2021_02_13_429885	506	14	of	of	IN
10_1101-2021_02_13_429885	506	15	high	high	JJ
10_1101-2021_02_13_429885	506	16	-	-	HYPH
10_1101-2021_02_13_429885	506	17	resolution	resolution	NN
10_1101-2021_02_13_429885	506	18	whole	whole	JJ
10_1101-2021_02_13_429885	506	19	genome	genome	JJ
10_1101-2021_02_13_429885	506	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	506	21	.	.	.
10_1101-2021_02_13_429885	507	1	Supplementary	supplementary	JJ
10_1101-2021_02_13_429885	507	2	Figures	Figures	NNPS
10_1101-2021_02_13_429885	507	3	Supplementary	Supplementary	NNP
10_1101-2021_02_13_429885	507	4	Figure	Figure	NNP
10_1101-2021_02_13_429885	507	5	S1	S1	NNS
10_1101-2021_02_13_429885	507	6	.	.	.
10_1101-2021_02_13_429885	508	1	​PCAWG	​pcawg	ADD
10_1101-2021_02_13_429885	508	2	sample	sample	VB
10_1101-2021_02_13_429885	508	3	with	with	IN
10_1101-2021_02_13_429885	508	4	low	low	JJ
10_1101-2021_02_13_429885	508	5	mutational	mutational	JJ
10_1101-2021_02_13_429885	508	6	burden	burden	NN
10_1101-2021_02_13_429885	508	7	.	.	.
10_1101-2021_02_13_429885	509	1	Supplementary	Supplementary	NNP
10_1101-2021_02_13_429885	509	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	509	3	S2	s2	NN
10_1101-2021_02_13_429885	509	4	.	.	.
10_1101-2021_02_13_429885	510	1	​Sample​	​sample​	PRP
10_1101-2021_02_13_429885	510	2	​Set7_55	​Set7_55	NNP
10_1101-2021_02_13_429885	510	3	(	(	-LRB-
10_1101-2021_02_13_429885	510	4	multi	multi	JJ
10_1101-2021_02_13_429885	510	5	-	-	JJ
10_1101-2021_02_13_429885	510	6	region	region	JJ
10_1101-2021_02_13_429885	510	7	)	)	-RRB-
10_1101-2021_02_13_429885	510	8	.	.	.
10_1101-2021_02_13_429885	511	1	Supplementary	supplementary	JJ
10_1101-2021_02_13_429885	511	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	511	3	S3	S3	NNP
10_1101-2021_02_13_429885	511	4	.	.	.
10_1101-2021_02_13_429885	512	1	​Sample​	​Sample​	NNP
10_1101-2021_02_13_429885	512	2	​Set7_59	​Set7_59	NNP
10_1101-2021_02_13_429885	512	3	(	(	-LRB-
10_1101-2021_02_13_429885	512	4	multi	multi	JJ
10_1101-2021_02_13_429885	512	5	-	-	JJ
10_1101-2021_02_13_429885	512	6	region	region	JJ
10_1101-2021_02_13_429885	512	7	)	)	-RRB-
10_1101-2021_02_13_429885	512	8	.	.	.
10_1101-2021_02_13_429885	513	1	Supplementary	Supplementary	NNP
10_1101-2021_02_13_429885	513	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	513	3	S4	s4	NN
10_1101-2021_02_13_429885	513	4	.	.	.
10_1101-2021_02_13_429885	514	1	​Sample​	​sample​	CD
10_1101-2021_02_13_429885	514	2	​Set7_62	​Set7_62	NNP
10_1101-2021_02_13_429885	514	3	(	(	-LRB-
10_1101-2021_02_13_429885	514	4	multi	multi	JJ
10_1101-2021_02_13_429885	514	5	-	-	JJ
10_1101-2021_02_13_429885	514	6	region	region	JJ
10_1101-2021_02_13_429885	514	7	)	)	-RRB-
10_1101-2021_02_13_429885	514	8	.	.	.
10_1101-2021_02_13_429885	515	1	Supplementary	Supplementary	NNP
10_1101-2021_02_13_429885	515	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	515	3	S5	s5	NN
10_1101-2021_02_13_429885	515	4	.	.	.
10_1101-2021_02_13_429885	516	1	​Sample​	​sample​	ADD
10_1101-2021_02_13_429885	516	2	​Set6_42	​Set6_42	NNP
10_1101-2021_02_13_429885	516	3	(	(	-LRB-
10_1101-2021_02_13_429885	516	4	multi	multi	JJ
10_1101-2021_02_13_429885	516	5	-	-	JJ
10_1101-2021_02_13_429885	516	6	region	region	JJ
10_1101-2021_02_13_429885	516	7	)	)	-RRB-
10_1101-2021_02_13_429885	516	8	.	.	.
10_1101-2021_02_13_429885	517	1	Supplementary	supplementary	JJ
10_1101-2021_02_13_429885	517	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	517	3	S6	s6	NN
10_1101-2021_02_13_429885	517	4	.	.	.
10_1101-2021_02_13_429885	518	1	​Sample​	​sample​	PRP
10_1101-2021_02_13_429885	518	2	​Set6_44	​Set6_44	NNP
10_1101-2021_02_13_429885	518	3	(	(	-LRB-
10_1101-2021_02_13_429885	518	4	multi	multi	JJ
10_1101-2021_02_13_429885	518	5	-	-	JJ
10_1101-2021_02_13_429885	518	6	region	region	JJ
10_1101-2021_02_13_429885	518	7	)	)	-RRB-
10_1101-2021_02_13_429885	518	8	.	.	.
10_1101-2021_02_13_429885	519	1	Supplementary	supplementary	JJ
10_1101-2021_02_13_429885	519	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	519	3	S7	S7	NNP
10_1101-2021_02_13_429885	519	4	.	.	.
10_1101-2021_02_13_429885	520	1	​Sample​	​sample​	PRP
10_1101-2021_02_13_429885	520	2	​Set6_45	​Set6_45	NNP
10_1101-2021_02_13_429885	520	3	(	(	-LRB-
10_1101-2021_02_13_429885	520	4	multi	multi	JJ
10_1101-2021_02_13_429885	520	5	-	-	JJ
10_1101-2021_02_13_429885	520	6	region	region	JJ
10_1101-2021_02_13_429885	520	7	)	)	-RRB-
10_1101-2021_02_13_429885	520	8	.	.	.
10_1101-2021_02_13_429885	521	1	Supplementary	Supplementary	NNP
10_1101-2021_02_13_429885	521	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	521	3	S8	S8	NNP
10_1101-2021_02_13_429885	521	4	.	.	.
10_1101-2021_02_13_429885	522	1	​Sample​	​sample​	ADD
10_1101-2021_02_13_429885	522	2	​Set6_46	​Set6_46	NNP
10_1101-2021_02_13_429885	522	3	(	(	-LRB-
10_1101-2021_02_13_429885	522	4	multi	multi	JJ
10_1101-2021_02_13_429885	522	5	-	-	JJ
10_1101-2021_02_13_429885	522	6	region	region	JJ
10_1101-2021_02_13_429885	522	7	)	)	-RRB-
10_1101-2021_02_13_429885	522	8	.	.	.
10_1101-2021_02_13_429885	523	1	Supplementary	supplementary	JJ
10_1101-2021_02_13_429885	523	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	523	3	S9	s9	NN
10_1101-2021_02_13_429885	523	4	.	.	.
10_1101-2021_02_13_429885	524	1	​Sample​	​Sample​	-LRB-
10_1101-2021_02_13_429885	524	2	​Set6_47	​Set6_47	NNP
10_1101-2021_02_13_429885	524	3	(	(	-LRB-
10_1101-2021_02_13_429885	524	4	multi	multi	JJ
10_1101-2021_02_13_429885	524	5	-	-	JJ
10_1101-2021_02_13_429885	524	6	region	region	JJ
10_1101-2021_02_13_429885	524	7	)	)	-RRB-
10_1101-2021_02_13_429885	524	8	.	.	.
10_1101-2021_02_13_429885	525	1	Supplementary	supplementary	JJ
10_1101-2021_02_13_429885	525	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	525	3	S10	S10	NNP
10_1101-2021_02_13_429885	525	4	.	.	.
10_1101-2021_02_13_429885	526	1	​Sample​	​sample​	PRP
10_1101-2021_02_13_429885	526	2	​Set6_48	​Set6_48	NNP
10_1101-2021_02_13_429885	526	3	(	(	-LRB-
10_1101-2021_02_13_429885	526	4	multi	multi	JJ
10_1101-2021_02_13_429885	526	5	-	-	JJ
10_1101-2021_02_13_429885	526	6	region	region	JJ
10_1101-2021_02_13_429885	526	7	)	)	-RRB-
10_1101-2021_02_13_429885	526	8	.	.	.
10_1101-2021_02_13_429885	527	1	Supplementary	supplementary	JJ
10_1101-2021_02_13_429885	527	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	527	3	S11	S11	NNP
10_1101-2021_02_13_429885	527	4	.	.	.
10_1101-2021_02_13_429885	528	1	​PCAWG	​pcawg	ADD
10_1101-2021_02_13_429885	528	2	sample	sample	NNP
10_1101-2021_02_13_429885	528	3	with	with	IN
10_1101-2021_02_13_429885	528	4	overstimated	overstimated	JJ
10_1101-2021_02_13_429885	528	5	100	100	CD
10_1101-2021_02_13_429885	528	6	%	%	NN
10_1101-2021_02_13_429885	528	7	purity	purity	NN
10_1101-2021_02_13_429885	528	8	.	.	.
10_1101-2021_02_13_429885	529	1	Supplementary	Supplementary	NNP
10_1101-2021_02_13_429885	529	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	529	3	S12	S12	NNP
10_1101-2021_02_13_429885	529	4	.	.	.
10_1101-2021_02_13_429885	530	1	​PCAWG	​pcawg	ADD
10_1101-2021_02_13_429885	530	2	sample	sample	VB
10_1101-2021_02_13_429885	530	3	with	with	IN
10_1101-2021_02_13_429885	530	4	true	true	JJ
10_1101-2021_02_13_429885	530	5	99	99	CD
10_1101-2021_02_13_429885	530	6	%	%	NN
10_1101-2021_02_13_429885	530	7	purity	purity	NN
10_1101-2021_02_13_429885	530	8	.	.	.
10_1101-2021_02_13_429885	531	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	531	2	-	-	:
10_1101-2021_02_13_429885	531	3	BY	by	IN
10_1101-2021_02_13_429885	531	4	-	-	HYPH
10_1101-2021_02_13_429885	531	5	NC	NC	NNP
10_1101-2021_02_13_429885	531	6	-	-	HYPH
10_1101-2021_02_13_429885	531	7	ND	ND	NNP
10_1101-2021_02_13_429885	531	8	4.0	4.0	CD
10_1101-2021_02_13_429885	531	9	International	International	NNP
10_1101-2021_02_13_429885	531	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	531	11	under	under	IN
10_1101-2021_02_13_429885	531	12	a	a	DT
10_1101-2021_02_13_429885	531	13	(	(	-LRB-
10_1101-2021_02_13_429885	531	14	which	which	WDT
10_1101-2021_02_13_429885	531	15	was	be	VBD
10_1101-2021_02_13_429885	531	16	not	not	RB
10_1101-2021_02_13_429885	531	17	certified	certify	VBN
10_1101-2021_02_13_429885	531	18	by	by	IN
10_1101-2021_02_13_429885	531	19	peer	peer	NN
10_1101-2021_02_13_429885	531	20	review	review	NN
10_1101-2021_02_13_429885	531	21	)	)	-RRB-
10_1101-2021_02_13_429885	531	22	is	be	VBZ
10_1101-2021_02_13_429885	531	23	the	the	DT
10_1101-2021_02_13_429885	531	24	author	author	NN
10_1101-2021_02_13_429885	531	25	/	/	SYM
10_1101-2021_02_13_429885	531	26	funder	funder	NN
10_1101-2021_02_13_429885	531	27	,	,	,
10_1101-2021_02_13_429885	531	28	who	who	WP
10_1101-2021_02_13_429885	531	29	has	have	VBZ
10_1101-2021_02_13_429885	531	30	granted	grant	VBN
10_1101-2021_02_13_429885	531	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	531	32	a	a	DT
10_1101-2021_02_13_429885	531	33	license	license	NN
10_1101-2021_02_13_429885	531	34	to	to	TO
10_1101-2021_02_13_429885	531	35	display	display	VB
10_1101-2021_02_13_429885	531	36	the	the	DT
10_1101-2021_02_13_429885	531	37	preprint	preprint	NN
10_1101-2021_02_13_429885	531	38	in	in	IN
10_1101-2021_02_13_429885	531	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	531	40	.	.	.
10_1101-2021_02_13_429885	532	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	532	2	is	be	VBZ
10_1101-2021_02_13_429885	532	3	made	make	VBN
10_1101-2021_02_13_429885	532	4	The	the	DT
10_1101-2021_02_13_429885	532	5	copyright	copyright	NN
10_1101-2021_02_13_429885	532	6	holder	holder	NN
10_1101-2021_02_13_429885	532	7	for	for	IN
10_1101-2021_02_13_429885	532	8	this	this	DT
10_1101-2021_02_13_429885	532	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	532	10	version	version	NN
10_1101-2021_02_13_429885	532	11	posted	post	VBD
10_1101-2021_02_13_429885	532	12	February	February	NNP
10_1101-2021_02_13_429885	532	13	13	13	CD
10_1101-2021_02_13_429885	532	14	,	,	,
10_1101-2021_02_13_429885	532	15	2021	2021	CD
10_1101-2021_02_13_429885	532	16	.	.	.
10_1101-2021_02_13_429885	532	17	;	;	:
10_1101-2021_02_13_429885	532	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	532	19	:	:	:
10_1101-2021_02_13_429885	532	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	532	21	preprint	preprint	NN
10_1101-2021_02_13_429885	532	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	532	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	532	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	532	25	et	et	FW
10_1101-2021_02_13_429885	532	26	al	al	NNP
10_1101-2021_02_13_429885	532	27	.	.	.
10_1101-2021_02_13_429885	533	1	A	a	DT
10_1101-2021_02_13_429885	533	2	fully	fully	RB
10_1101-2021_02_13_429885	533	3	automated	automate	VBN
10_1101-2021_02_13_429885	533	4	approach	approach	NN
10_1101-2021_02_13_429885	533	5	for	for	IN
10_1101-2021_02_13_429885	533	6	quality	quality	NN
10_1101-2021_02_13_429885	533	7	control	control	NN
10_1101-2021_02_13_429885	533	8	of	of	IN
10_1101-2021_02_13_429885	533	9	cancer	cancer	NN
10_1101-2021_02_13_429885	533	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	533	11	in	in	IN
10_1101-2021_02_13_429885	533	12	the	the	DT
10_1101-2021_02_13_429885	533	13	era	era	NN
10_1101-2021_02_13_429885	533	14	of	of	IN
10_1101-2021_02_13_429885	533	15	high	high	JJ
10_1101-2021_02_13_429885	533	16	-	-	HYPH
10_1101-2021_02_13_429885	533	17	resolution	resolution	NN
10_1101-2021_02_13_429885	533	18	whole	whole	JJ
10_1101-2021_02_13_429885	533	19	genome	genome	JJ
10_1101-2021_02_13_429885	533	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	533	21	.	.	.
10_1101-2021_02_13_429885	534	1	Supplementary	supplementary	JJ
10_1101-2021_02_13_429885	534	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	534	3	S1	S1	NNS
10_1101-2021_02_13_429885	534	4	.	.	.
10_1101-2021_02_13_429885	535	1	​Example	​Example	NNP
10_1101-2021_02_13_429885	535	2	PCAWG	PCAWG	NNP
10_1101-2021_02_13_429885	535	3	medulloblastoma	medulloblastoma	NN
10_1101-2021_02_13_429885	535	4	sample	sample	NN
10_1101-2021_02_13_429885	535	5	with	with	IN
10_1101-2021_02_13_429885	535	6	low	low	JJ
10_1101-2021_02_13_429885	535	7	-	-	HYPH
10_1101-2021_02_13_429885	535	8	mutational	mutational	JJ
10_1101-2021_02_13_429885	535	9	burden	burden	NN
10_1101-2021_02_13_429885	535	10	,	,	,
10_1101-2021_02_13_429885	535	11	which	which	WDT
10_1101-2021_02_13_429885	535	12	passes	pass	VBZ
10_1101-2021_02_13_429885	535	13	data	data	NN
10_1101-2021_02_13_429885	535	14	QC	QC	NNP
10_1101-2021_02_13_429885	535	15	with	with	IN
10_1101-2021_02_13_429885	535	16	CNAqc	CNAqc	NNP
10_1101-2021_02_13_429885	535	17	.	.	.
10_1101-2021_02_13_429885	536	1	​a	​a	NNS
10_1101-2021_02_13_429885	536	2	.	.	.
10_1101-2021_02_13_429885	537	1	​Data	​Data	NNP
10_1101-2021_02_13_429885	537	2	for	for	IN
10_1101-2021_02_13_429885	537	3	the	the	DT
10_1101-2021_02_13_429885	537	4	sample	sample	NN
10_1101-2021_02_13_429885	537	5	(	(	-LRB-
10_1101-2021_02_13_429885	537	6	genome	genome	NN
10_1101-2021_02_13_429885	537	7	-	-	HYPH
10_1101-2021_02_13_429885	537	8	wide	wide	JJ
10_1101-2021_02_13_429885	537	9	CNA	cna	NN
10_1101-2021_02_13_429885	537	10	segments	segment	NNS
10_1101-2021_02_13_429885	537	11	,	,	,
10_1101-2021_02_13_429885	537	12	CCF	CCF	NNP
10_1101-2021_02_13_429885	537	13	and	and	CC
10_1101-2021_02_13_429885	537	14	read	read	VBD
10_1101-2021_02_13_429885	537	15	counts	count	NNS
10_1101-2021_02_13_429885	537	16	distribution	distribution	NN
10_1101-2021_02_13_429885	537	17	)	)	-RRB-
10_1101-2021_02_13_429885	537	18	.	.	.
10_1101-2021_02_13_429885	538	1	Note	note	VB
10_1101-2021_02_13_429885	538	2	that	that	IN
10_1101-2021_02_13_429885	538	3	this	this	DT
10_1101-2021_02_13_429885	538	4	sample	sample	NN
10_1101-2021_02_13_429885	538	5	has	have	VBZ
10_1101-2021_02_13_429885	538	6	only	only	RB
10_1101-2021_02_13_429885	538	7	76	76	CD
10_1101-2021_02_13_429885	538	8	SNVs	SNVs	NNPS
10_1101-2021_02_13_429885	538	9	in	in	IN
10_1101-2021_02_13_429885	538	10	diploid	diploid	JJ
10_1101-2021_02_13_429885	538	11	tumour	tumour	NN
10_1101-2021_02_13_429885	538	12	regions	region	NNS
10_1101-2021_02_13_429885	538	13	,	,	,
10_1101-2021_02_13_429885	538	14	like	like	IN
10_1101-2021_02_13_429885	538	15	we	-PRON-	PRP
10_1101-2021_02_13_429885	538	16	observe	observe	VBP
10_1101-2021_02_13_429885	538	17	in	in	IN
10_1101-2021_02_13_429885	538	18	whole	whole	NN
10_1101-2021_02_13_429885	538	19	-	-	HYPH
10_1101-2021_02_13_429885	538	20	exome	exome	NN
10_1101-2021_02_13_429885	538	21	assays	assay	NNS
10_1101-2021_02_13_429885	538	22	.	.	.
10_1101-2021_02_13_429885	539	1	​b	​b	NNP
10_1101-2021_02_13_429885	539	2	,	,	,
10_1101-2021_02_13_429885	539	3	c	c	NNP
10_1101-2021_02_13_429885	539	4	.	.	.
10_1101-2021_02_13_429885	540	1	Peak	peak	VB
10_1101-2021_02_13_429885	540	2	analysis	analysis	NN
10_1101-2021_02_13_429885	540	3	and	and	CC
10_1101-2021_02_13_429885	540	4	CCF	ccf	NN
10_1101-2021_02_13_429885	540	5	computation	computation	NN
10_1101-2021_02_13_429885	540	6	for	for	IN
10_1101-2021_02_13_429885	540	7	diploid	diploid	NNP
10_1101-2021_02_13_429885	540	8	SNVs	SNVs	NNPS
10_1101-2021_02_13_429885	540	9	.	.	.
10_1101-2021_02_13_429885	541	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	541	2	-	-	:
10_1101-2021_02_13_429885	541	3	BY	by	IN
10_1101-2021_02_13_429885	541	4	-	-	HYPH
10_1101-2021_02_13_429885	541	5	NC	NC	NNP
10_1101-2021_02_13_429885	541	6	-	-	HYPH
10_1101-2021_02_13_429885	541	7	ND	ND	NNP
10_1101-2021_02_13_429885	541	8	4.0	4.0	CD
10_1101-2021_02_13_429885	541	9	International	International	NNP
10_1101-2021_02_13_429885	541	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	541	11	under	under	IN
10_1101-2021_02_13_429885	541	12	a	a	DT
10_1101-2021_02_13_429885	541	13	(	(	-LRB-
10_1101-2021_02_13_429885	541	14	which	which	WDT
10_1101-2021_02_13_429885	541	15	was	be	VBD
10_1101-2021_02_13_429885	541	16	not	not	RB
10_1101-2021_02_13_429885	541	17	certified	certify	VBN
10_1101-2021_02_13_429885	541	18	by	by	IN
10_1101-2021_02_13_429885	541	19	peer	peer	NN
10_1101-2021_02_13_429885	541	20	review	review	NN
10_1101-2021_02_13_429885	541	21	)	)	-RRB-
10_1101-2021_02_13_429885	541	22	is	be	VBZ
10_1101-2021_02_13_429885	541	23	the	the	DT
10_1101-2021_02_13_429885	541	24	author	author	NN
10_1101-2021_02_13_429885	541	25	/	/	SYM
10_1101-2021_02_13_429885	541	26	funder	funder	NN
10_1101-2021_02_13_429885	541	27	,	,	,
10_1101-2021_02_13_429885	541	28	who	who	WP
10_1101-2021_02_13_429885	541	29	has	have	VBZ
10_1101-2021_02_13_429885	541	30	granted	grant	VBN
10_1101-2021_02_13_429885	541	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	541	32	a	a	DT
10_1101-2021_02_13_429885	541	33	license	license	NN
10_1101-2021_02_13_429885	541	34	to	to	TO
10_1101-2021_02_13_429885	541	35	display	display	VB
10_1101-2021_02_13_429885	541	36	the	the	DT
10_1101-2021_02_13_429885	541	37	preprint	preprint	NN
10_1101-2021_02_13_429885	541	38	in	in	IN
10_1101-2021_02_13_429885	541	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	541	40	.	.	.
10_1101-2021_02_13_429885	542	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	542	2	is	be	VBZ
10_1101-2021_02_13_429885	542	3	made	make	VBN
10_1101-2021_02_13_429885	542	4	The	the	DT
10_1101-2021_02_13_429885	542	5	copyright	copyright	NN
10_1101-2021_02_13_429885	542	6	holder	holder	NN
10_1101-2021_02_13_429885	542	7	for	for	IN
10_1101-2021_02_13_429885	542	8	this	this	DT
10_1101-2021_02_13_429885	542	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	542	10	version	version	NN
10_1101-2021_02_13_429885	542	11	posted	post	VBD
10_1101-2021_02_13_429885	542	12	February	February	NNP
10_1101-2021_02_13_429885	542	13	13	13	CD
10_1101-2021_02_13_429885	542	14	,	,	,
10_1101-2021_02_13_429885	542	15	2021	2021	CD
10_1101-2021_02_13_429885	542	16	.	.	.
10_1101-2021_02_13_429885	542	17	;	;	:
10_1101-2021_02_13_429885	542	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	542	19	:	:	:
10_1101-2021_02_13_429885	542	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	542	21	preprint	preprint	NN
10_1101-2021_02_13_429885	542	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	542	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	542	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	542	25	et	et	FW
10_1101-2021_02_13_429885	542	26	al	al	NNP
10_1101-2021_02_13_429885	542	27	.	.	.
10_1101-2021_02_13_429885	543	1	A	a	DT
10_1101-2021_02_13_429885	543	2	fully	fully	RB
10_1101-2021_02_13_429885	543	3	automated	automate	VBN
10_1101-2021_02_13_429885	543	4	approach	approach	NN
10_1101-2021_02_13_429885	543	5	for	for	IN
10_1101-2021_02_13_429885	543	6	quality	quality	NN
10_1101-2021_02_13_429885	543	7	control	control	NN
10_1101-2021_02_13_429885	543	8	of	of	IN
10_1101-2021_02_13_429885	543	9	cancer	cancer	NN
10_1101-2021_02_13_429885	543	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	543	11	in	in	IN
10_1101-2021_02_13_429885	543	12	the	the	DT
10_1101-2021_02_13_429885	543	13	era	era	NN
10_1101-2021_02_13_429885	543	14	of	of	IN
10_1101-2021_02_13_429885	543	15	high	high	JJ
10_1101-2021_02_13_429885	543	16	-	-	HYPH
10_1101-2021_02_13_429885	543	17	resolution	resolution	NN
10_1101-2021_02_13_429885	543	18	whole	whole	JJ
10_1101-2021_02_13_429885	543	19	genome	genome	JJ
10_1101-2021_02_13_429885	543	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	543	21	.	.	.
10_1101-2021_02_13_429885	544	1	Supplementary	Supplementary	NNP
10_1101-2021_02_13_429885	544	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	544	3	S2	s2	NN
10_1101-2021_02_13_429885	544	4	.	.	.
10_1101-2021_02_13_429885	545	1	​Colorectal	​colorectal	JJ
10_1101-2021_02_13_429885	545	2	multi	multi	JJ
10_1101-2021_02_13_429885	545	3	-	-	JJ
10_1101-2021_02_13_429885	545	4	region	region	JJ
10_1101-2021_02_13_429885	545	5	sample	sample	NN
10_1101-2021_02_13_429885	545	6	Set7_55	Set7_55	NNP
10_1101-2021_02_13_429885	545	7	for	for	IN
10_1101-2021_02_13_429885	545	8	patient	patient	NN
10_1101-2021_02_13_429885	545	9	Set7	Set7	NNP
10_1101-2021_02_13_429885	545	10	(	(	-LRB-
10_1101-2021_02_13_429885	545	11	see	see	VB
10_1101-2021_02_13_429885	545	12	also	also	RB
10_1101-2021_02_13_429885	545	13	Main	Main	NNP
10_1101-2021_02_13_429885	545	14	Text	Text	NNP
10_1101-2021_02_13_429885	545	15	​Figure	​figure	NN
10_1101-2021_02_13_429885	545	16	4	4	CD
10_1101-2021_02_13_429885	545	17	​	​	UH
10_1101-2021_02_13_429885	545	18	)	)	-RRB-
10_1101-2021_02_13_429885	545	19	.	.	.
10_1101-2021_02_13_429885	546	1	​a	​a	NNS
10_1101-2021_02_13_429885	546	2	.	.	.
10_1101-2021_02_13_429885	547	1	​Data	​Data	NNP
10_1101-2021_02_13_429885	547	2	for	for	IN
10_1101-2021_02_13_429885	547	3	the	the	DT
10_1101-2021_02_13_429885	547	4	sample	sample	NN
10_1101-2021_02_13_429885	547	5	(	(	-LRB-
10_1101-2021_02_13_429885	547	6	genome	genome	NN
10_1101-2021_02_13_429885	547	7	-	-	HYPH
10_1101-2021_02_13_429885	547	8	wide	wide	JJ
10_1101-2021_02_13_429885	547	9	CNA	cna	NN
10_1101-2021_02_13_429885	547	10	segments	segment	NNS
10_1101-2021_02_13_429885	547	11	,	,	,
10_1101-2021_02_13_429885	547	12	CCF	CCF	NNP
10_1101-2021_02_13_429885	547	13	and	and	CC
10_1101-2021_02_13_429885	547	14	read	read	VBD
10_1101-2021_02_13_429885	547	15	counts	count	NNS
10_1101-2021_02_13_429885	547	16	distribution	distribution	NN
10_1101-2021_02_13_429885	547	17	)	)	-RRB-
10_1101-2021_02_13_429885	547	18	.	.	.
10_1101-2021_02_13_429885	548	1	​b	​b	NNP
10_1101-2021_02_13_429885	548	2	,	,	,
10_1101-2021_02_13_429885	548	3	c	c	NNP
10_1101-2021_02_13_429885	548	4	.	.	.
10_1101-2021_02_13_429885	549	1	Peak	peak	VB
10_1101-2021_02_13_429885	549	2	analysis	analysis	NN
10_1101-2021_02_13_429885	549	3	and	and	CC
10_1101-2021_02_13_429885	549	4	CCF	ccf	NN
10_1101-2021_02_13_429885	549	5	computation	computation	NN
10_1101-2021_02_13_429885	549	6	for	for	IN
10_1101-2021_02_13_429885	549	7	the	the	DT
10_1101-2021_02_13_429885	549	8	sample	sample	NN
10_1101-2021_02_13_429885	549	9	.	.	.
10_1101-2021_02_13_429885	550	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	550	2	-	-	:
10_1101-2021_02_13_429885	550	3	BY	by	IN
10_1101-2021_02_13_429885	550	4	-	-	HYPH
10_1101-2021_02_13_429885	550	5	NC	NC	NNP
10_1101-2021_02_13_429885	550	6	-	-	HYPH
10_1101-2021_02_13_429885	550	7	ND	ND	NNP
10_1101-2021_02_13_429885	550	8	4.0	4.0	CD
10_1101-2021_02_13_429885	550	9	International	International	NNP
10_1101-2021_02_13_429885	550	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	550	11	under	under	IN
10_1101-2021_02_13_429885	550	12	a	a	DT
10_1101-2021_02_13_429885	550	13	(	(	-LRB-
10_1101-2021_02_13_429885	550	14	which	which	WDT
10_1101-2021_02_13_429885	550	15	was	be	VBD
10_1101-2021_02_13_429885	550	16	not	not	RB
10_1101-2021_02_13_429885	550	17	certified	certify	VBN
10_1101-2021_02_13_429885	550	18	by	by	IN
10_1101-2021_02_13_429885	550	19	peer	peer	NN
10_1101-2021_02_13_429885	550	20	review	review	NN
10_1101-2021_02_13_429885	550	21	)	)	-RRB-
10_1101-2021_02_13_429885	550	22	is	be	VBZ
10_1101-2021_02_13_429885	550	23	the	the	DT
10_1101-2021_02_13_429885	550	24	author	author	NN
10_1101-2021_02_13_429885	550	25	/	/	SYM
10_1101-2021_02_13_429885	550	26	funder	funder	NN
10_1101-2021_02_13_429885	550	27	,	,	,
10_1101-2021_02_13_429885	550	28	who	who	WP
10_1101-2021_02_13_429885	550	29	has	have	VBZ
10_1101-2021_02_13_429885	550	30	granted	grant	VBN
10_1101-2021_02_13_429885	550	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	550	32	a	a	DT
10_1101-2021_02_13_429885	550	33	license	license	NN
10_1101-2021_02_13_429885	550	34	to	to	TO
10_1101-2021_02_13_429885	550	35	display	display	VB
10_1101-2021_02_13_429885	550	36	the	the	DT
10_1101-2021_02_13_429885	550	37	preprint	preprint	NN
10_1101-2021_02_13_429885	550	38	in	in	IN
10_1101-2021_02_13_429885	550	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	550	40	.	.	.
10_1101-2021_02_13_429885	551	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	551	2	is	be	VBZ
10_1101-2021_02_13_429885	551	3	made	make	VBN
10_1101-2021_02_13_429885	551	4	The	the	DT
10_1101-2021_02_13_429885	551	5	copyright	copyright	NN
10_1101-2021_02_13_429885	551	6	holder	holder	NN
10_1101-2021_02_13_429885	551	7	for	for	IN
10_1101-2021_02_13_429885	551	8	this	this	DT
10_1101-2021_02_13_429885	551	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	551	10	version	version	NN
10_1101-2021_02_13_429885	551	11	posted	post	VBD
10_1101-2021_02_13_429885	551	12	February	February	NNP
10_1101-2021_02_13_429885	551	13	13	13	CD
10_1101-2021_02_13_429885	551	14	,	,	,
10_1101-2021_02_13_429885	551	15	2021	2021	CD
10_1101-2021_02_13_429885	551	16	.	.	.
10_1101-2021_02_13_429885	551	17	;	;	:
10_1101-2021_02_13_429885	551	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	551	19	:	:	:
10_1101-2021_02_13_429885	551	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	551	21	preprint	preprint	NN
10_1101-2021_02_13_429885	551	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	551	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	551	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	551	25	et	et	FW
10_1101-2021_02_13_429885	551	26	al	al	NNP
10_1101-2021_02_13_429885	551	27	.	.	.
10_1101-2021_02_13_429885	552	1	A	a	DT
10_1101-2021_02_13_429885	552	2	fully	fully	RB
10_1101-2021_02_13_429885	552	3	automated	automate	VBN
10_1101-2021_02_13_429885	552	4	approach	approach	NN
10_1101-2021_02_13_429885	552	5	for	for	IN
10_1101-2021_02_13_429885	552	6	quality	quality	NN
10_1101-2021_02_13_429885	552	7	control	control	NN
10_1101-2021_02_13_429885	552	8	of	of	IN
10_1101-2021_02_13_429885	552	9	cancer	cancer	NN
10_1101-2021_02_13_429885	552	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	552	11	in	in	IN
10_1101-2021_02_13_429885	552	12	the	the	DT
10_1101-2021_02_13_429885	552	13	era	era	NN
10_1101-2021_02_13_429885	552	14	of	of	IN
10_1101-2021_02_13_429885	552	15	high	high	JJ
10_1101-2021_02_13_429885	552	16	-	-	HYPH
10_1101-2021_02_13_429885	552	17	resolution	resolution	NN
10_1101-2021_02_13_429885	552	18	whole	whole	JJ
10_1101-2021_02_13_429885	552	19	genome	genome	JJ
10_1101-2021_02_13_429885	552	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	552	21	.	.	.
10_1101-2021_02_13_429885	553	1	Supplementary	supplementary	JJ
10_1101-2021_02_13_429885	553	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	553	3	S3	S3	NNP
10_1101-2021_02_13_429885	553	4	.	.	.
10_1101-2021_02_13_429885	554	1	​Colorectal	​colorectal	JJ
10_1101-2021_02_13_429885	554	2	multi	multi	JJ
10_1101-2021_02_13_429885	554	3	-	-	JJ
10_1101-2021_02_13_429885	554	4	region	region	JJ
10_1101-2021_02_13_429885	554	5	sample	sample	NN
10_1101-2021_02_13_429885	554	6	Set7_59	Set7_59	NNP
10_1101-2021_02_13_429885	554	7	for	for	IN
10_1101-2021_02_13_429885	554	8	patient	patient	NN
10_1101-2021_02_13_429885	554	9	Set7	Set7	NNP
10_1101-2021_02_13_429885	554	10	(	(	-LRB-
10_1101-2021_02_13_429885	554	11	see	see	VB
10_1101-2021_02_13_429885	554	12	also	also	RB
10_1101-2021_02_13_429885	554	13	Main	Main	NNP
10_1101-2021_02_13_429885	554	14	Text	Text	NNP
10_1101-2021_02_13_429885	554	15	​Figure	​figure	NN
10_1101-2021_02_13_429885	554	16	4	4	CD
10_1101-2021_02_13_429885	554	17	​	​	UH
10_1101-2021_02_13_429885	554	18	)	)	-RRB-
10_1101-2021_02_13_429885	554	19	.	.	.
10_1101-2021_02_13_429885	555	1	​a	​a	NNS
10_1101-2021_02_13_429885	555	2	.	.	.
10_1101-2021_02_13_429885	556	1	​Data	​Data	NNP
10_1101-2021_02_13_429885	556	2	for	for	IN
10_1101-2021_02_13_429885	556	3	the	the	DT
10_1101-2021_02_13_429885	556	4	sample	sample	NN
10_1101-2021_02_13_429885	556	5	(	(	-LRB-
10_1101-2021_02_13_429885	556	6	genome	genome	NN
10_1101-2021_02_13_429885	556	7	-	-	HYPH
10_1101-2021_02_13_429885	556	8	wide	wide	JJ
10_1101-2021_02_13_429885	556	9	CNA	cna	NN
10_1101-2021_02_13_429885	556	10	segments	segment	NNS
10_1101-2021_02_13_429885	556	11	,	,	,
10_1101-2021_02_13_429885	556	12	CCF	CCF	NNP
10_1101-2021_02_13_429885	556	13	and	and	CC
10_1101-2021_02_13_429885	556	14	read	read	VBD
10_1101-2021_02_13_429885	556	15	counts	count	NNS
10_1101-2021_02_13_429885	556	16	distribution	distribution	NN
10_1101-2021_02_13_429885	556	17	)	)	-RRB-
10_1101-2021_02_13_429885	556	18	.	.	.
10_1101-2021_02_13_429885	557	1	​b	​b	NNP
10_1101-2021_02_13_429885	557	2	,	,	,
10_1101-2021_02_13_429885	557	3	c	c	NNP
10_1101-2021_02_13_429885	557	4	.	.	.
10_1101-2021_02_13_429885	558	1	Peak	peak	VB
10_1101-2021_02_13_429885	558	2	analysis	analysis	NN
10_1101-2021_02_13_429885	558	3	and	and	CC
10_1101-2021_02_13_429885	558	4	CCF	ccf	NN
10_1101-2021_02_13_429885	558	5	computation	computation	NN
10_1101-2021_02_13_429885	558	6	for	for	IN
10_1101-2021_02_13_429885	558	7	the	the	DT
10_1101-2021_02_13_429885	558	8	sample	sample	NN
10_1101-2021_02_13_429885	558	9	.	.	.
10_1101-2021_02_13_429885	559	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	559	2	-	-	:
10_1101-2021_02_13_429885	559	3	BY	by	IN
10_1101-2021_02_13_429885	559	4	-	-	HYPH
10_1101-2021_02_13_429885	559	5	NC	NC	NNP
10_1101-2021_02_13_429885	559	6	-	-	HYPH
10_1101-2021_02_13_429885	559	7	ND	ND	NNP
10_1101-2021_02_13_429885	559	8	4.0	4.0	CD
10_1101-2021_02_13_429885	559	9	International	International	NNP
10_1101-2021_02_13_429885	559	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	559	11	under	under	IN
10_1101-2021_02_13_429885	559	12	a	a	DT
10_1101-2021_02_13_429885	559	13	(	(	-LRB-
10_1101-2021_02_13_429885	559	14	which	which	WDT
10_1101-2021_02_13_429885	559	15	was	be	VBD
10_1101-2021_02_13_429885	559	16	not	not	RB
10_1101-2021_02_13_429885	559	17	certified	certify	VBN
10_1101-2021_02_13_429885	559	18	by	by	IN
10_1101-2021_02_13_429885	559	19	peer	peer	NN
10_1101-2021_02_13_429885	559	20	review	review	NN
10_1101-2021_02_13_429885	559	21	)	)	-RRB-
10_1101-2021_02_13_429885	559	22	is	be	VBZ
10_1101-2021_02_13_429885	559	23	the	the	DT
10_1101-2021_02_13_429885	559	24	author	author	NN
10_1101-2021_02_13_429885	559	25	/	/	SYM
10_1101-2021_02_13_429885	559	26	funder	funder	NN
10_1101-2021_02_13_429885	559	27	,	,	,
10_1101-2021_02_13_429885	559	28	who	who	WP
10_1101-2021_02_13_429885	559	29	has	have	VBZ
10_1101-2021_02_13_429885	559	30	granted	grant	VBN
10_1101-2021_02_13_429885	559	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	559	32	a	a	DT
10_1101-2021_02_13_429885	559	33	license	license	NN
10_1101-2021_02_13_429885	559	34	to	to	TO
10_1101-2021_02_13_429885	559	35	display	display	VB
10_1101-2021_02_13_429885	559	36	the	the	DT
10_1101-2021_02_13_429885	559	37	preprint	preprint	NN
10_1101-2021_02_13_429885	559	38	in	in	IN
10_1101-2021_02_13_429885	559	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	559	40	.	.	.
10_1101-2021_02_13_429885	560	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	560	2	is	be	VBZ
10_1101-2021_02_13_429885	560	3	made	make	VBN
10_1101-2021_02_13_429885	560	4	The	the	DT
10_1101-2021_02_13_429885	560	5	copyright	copyright	NN
10_1101-2021_02_13_429885	560	6	holder	holder	NN
10_1101-2021_02_13_429885	560	7	for	for	IN
10_1101-2021_02_13_429885	560	8	this	this	DT
10_1101-2021_02_13_429885	560	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	560	10	version	version	NN
10_1101-2021_02_13_429885	560	11	posted	post	VBD
10_1101-2021_02_13_429885	560	12	February	February	NNP
10_1101-2021_02_13_429885	560	13	13	13	CD
10_1101-2021_02_13_429885	560	14	,	,	,
10_1101-2021_02_13_429885	560	15	2021	2021	CD
10_1101-2021_02_13_429885	560	16	.	.	.
10_1101-2021_02_13_429885	560	17	;	;	:
10_1101-2021_02_13_429885	560	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	560	19	:	:	:
10_1101-2021_02_13_429885	560	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	560	21	preprint	preprint	NN
10_1101-2021_02_13_429885	560	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	560	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	560	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	560	25	et	et	FW
10_1101-2021_02_13_429885	560	26	al	al	NNP
10_1101-2021_02_13_429885	560	27	.	.	.
10_1101-2021_02_13_429885	561	1	A	a	DT
10_1101-2021_02_13_429885	561	2	fully	fully	RB
10_1101-2021_02_13_429885	561	3	automated	automate	VBN
10_1101-2021_02_13_429885	561	4	approach	approach	NN
10_1101-2021_02_13_429885	561	5	for	for	IN
10_1101-2021_02_13_429885	561	6	quality	quality	NN
10_1101-2021_02_13_429885	561	7	control	control	NN
10_1101-2021_02_13_429885	561	8	of	of	IN
10_1101-2021_02_13_429885	561	9	cancer	cancer	NN
10_1101-2021_02_13_429885	561	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	561	11	in	in	IN
10_1101-2021_02_13_429885	561	12	the	the	DT
10_1101-2021_02_13_429885	561	13	era	era	NN
10_1101-2021_02_13_429885	561	14	of	of	IN
10_1101-2021_02_13_429885	561	15	high	high	JJ
10_1101-2021_02_13_429885	561	16	-	-	HYPH
10_1101-2021_02_13_429885	561	17	resolution	resolution	NN
10_1101-2021_02_13_429885	561	18	whole	whole	JJ
10_1101-2021_02_13_429885	561	19	genome	genome	JJ
10_1101-2021_02_13_429885	561	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	561	21	.	.	.
10_1101-2021_02_13_429885	562	1	Supplementary	Supplementary	NNP
10_1101-2021_02_13_429885	562	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	562	3	S4	s4	NN
10_1101-2021_02_13_429885	562	4	.	.	.
10_1101-2021_02_13_429885	563	1	​Colorectal	​colorectal	JJ
10_1101-2021_02_13_429885	563	2	multi	multi	JJ
10_1101-2021_02_13_429885	563	3	-	-	JJ
10_1101-2021_02_13_429885	563	4	region	region	JJ
10_1101-2021_02_13_429885	563	5	sample	sample	NN
10_1101-2021_02_13_429885	563	6	Set7_62	Set7_62	NNP
10_1101-2021_02_13_429885	563	7	for	for	IN
10_1101-2021_02_13_429885	563	8	patient	patient	NN
10_1101-2021_02_13_429885	563	9	Set7	Set7	NNP
10_1101-2021_02_13_429885	563	10	(	(	-LRB-
10_1101-2021_02_13_429885	563	11	see	see	VB
10_1101-2021_02_13_429885	563	12	also	also	RB
10_1101-2021_02_13_429885	563	13	Main	Main	NNP
10_1101-2021_02_13_429885	563	14	Text	Text	NNP
10_1101-2021_02_13_429885	563	15	​Figure	​figure	NN
10_1101-2021_02_13_429885	563	16	4	4	CD
10_1101-2021_02_13_429885	563	17	​	​	UH
10_1101-2021_02_13_429885	563	18	)	)	-RRB-
10_1101-2021_02_13_429885	563	19	.	.	.
10_1101-2021_02_13_429885	564	1	​a	​a	NNS
10_1101-2021_02_13_429885	564	2	.	.	.
10_1101-2021_02_13_429885	565	1	​Data	​Data	NNP
10_1101-2021_02_13_429885	565	2	for	for	IN
10_1101-2021_02_13_429885	565	3	the	the	DT
10_1101-2021_02_13_429885	565	4	sample	sample	NN
10_1101-2021_02_13_429885	565	5	(	(	-LRB-
10_1101-2021_02_13_429885	565	6	genome	genome	NN
10_1101-2021_02_13_429885	565	7	-	-	HYPH
10_1101-2021_02_13_429885	565	8	wide	wide	JJ
10_1101-2021_02_13_429885	565	9	CNA	cna	NN
10_1101-2021_02_13_429885	565	10	segments	segment	NNS
10_1101-2021_02_13_429885	565	11	,	,	,
10_1101-2021_02_13_429885	565	12	CCF	CCF	NNP
10_1101-2021_02_13_429885	565	13	and	and	CC
10_1101-2021_02_13_429885	565	14	read	read	VBD
10_1101-2021_02_13_429885	565	15	counts	count	NNS
10_1101-2021_02_13_429885	565	16	distribution	distribution	NN
10_1101-2021_02_13_429885	565	17	)	)	-RRB-
10_1101-2021_02_13_429885	565	18	.	.	.
10_1101-2021_02_13_429885	566	1	​b	​b	NNP
10_1101-2021_02_13_429885	566	2	,	,	,
10_1101-2021_02_13_429885	566	3	c.​	c.​	NNP
10_1101-2021_02_13_429885	566	4	Peak	Peak	NNP
10_1101-2021_02_13_429885	566	5	analysis	analysis	NN
10_1101-2021_02_13_429885	566	6	and	and	CC
10_1101-2021_02_13_429885	566	7	CCF	ccf	NN
10_1101-2021_02_13_429885	566	8	computation	computation	NN
10_1101-2021_02_13_429885	566	9	for	for	IN
10_1101-2021_02_13_429885	566	10	the	the	DT
10_1101-2021_02_13_429885	566	11	sample	sample	NN
10_1101-2021_02_13_429885	566	12	.	.	.
10_1101-2021_02_13_429885	567	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	567	2	-	-	:
10_1101-2021_02_13_429885	567	3	BY	by	IN
10_1101-2021_02_13_429885	567	4	-	-	HYPH
10_1101-2021_02_13_429885	567	5	NC	NC	NNP
10_1101-2021_02_13_429885	567	6	-	-	HYPH
10_1101-2021_02_13_429885	567	7	ND	ND	NNP
10_1101-2021_02_13_429885	567	8	4.0	4.0	CD
10_1101-2021_02_13_429885	567	9	International	International	NNP
10_1101-2021_02_13_429885	567	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	567	11	under	under	IN
10_1101-2021_02_13_429885	567	12	a	a	DT
10_1101-2021_02_13_429885	567	13	(	(	-LRB-
10_1101-2021_02_13_429885	567	14	which	which	WDT
10_1101-2021_02_13_429885	567	15	was	be	VBD
10_1101-2021_02_13_429885	567	16	not	not	RB
10_1101-2021_02_13_429885	567	17	certified	certify	VBN
10_1101-2021_02_13_429885	567	18	by	by	IN
10_1101-2021_02_13_429885	567	19	peer	peer	NN
10_1101-2021_02_13_429885	567	20	review	review	NN
10_1101-2021_02_13_429885	567	21	)	)	-RRB-
10_1101-2021_02_13_429885	567	22	is	be	VBZ
10_1101-2021_02_13_429885	567	23	the	the	DT
10_1101-2021_02_13_429885	567	24	author	author	NN
10_1101-2021_02_13_429885	567	25	/	/	SYM
10_1101-2021_02_13_429885	567	26	funder	funder	NN
10_1101-2021_02_13_429885	567	27	,	,	,
10_1101-2021_02_13_429885	567	28	who	who	WP
10_1101-2021_02_13_429885	567	29	has	have	VBZ
10_1101-2021_02_13_429885	567	30	granted	grant	VBN
10_1101-2021_02_13_429885	567	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	567	32	a	a	DT
10_1101-2021_02_13_429885	567	33	license	license	NN
10_1101-2021_02_13_429885	567	34	to	to	TO
10_1101-2021_02_13_429885	567	35	display	display	VB
10_1101-2021_02_13_429885	567	36	the	the	DT
10_1101-2021_02_13_429885	567	37	preprint	preprint	NN
10_1101-2021_02_13_429885	567	38	in	in	IN
10_1101-2021_02_13_429885	567	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	567	40	.	.	.
10_1101-2021_02_13_429885	568	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	568	2	is	be	VBZ
10_1101-2021_02_13_429885	568	3	made	make	VBN
10_1101-2021_02_13_429885	568	4	The	the	DT
10_1101-2021_02_13_429885	568	5	copyright	copyright	NN
10_1101-2021_02_13_429885	568	6	holder	holder	NN
10_1101-2021_02_13_429885	568	7	for	for	IN
10_1101-2021_02_13_429885	568	8	this	this	DT
10_1101-2021_02_13_429885	568	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	568	10	version	version	NN
10_1101-2021_02_13_429885	568	11	posted	post	VBD
10_1101-2021_02_13_429885	568	12	February	February	NNP
10_1101-2021_02_13_429885	568	13	13	13	CD
10_1101-2021_02_13_429885	568	14	,	,	,
10_1101-2021_02_13_429885	568	15	2021	2021	CD
10_1101-2021_02_13_429885	568	16	.	.	.
10_1101-2021_02_13_429885	568	17	;	;	:
10_1101-2021_02_13_429885	568	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	568	19	:	:	:
10_1101-2021_02_13_429885	568	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	568	21	preprint	preprint	NN
10_1101-2021_02_13_429885	568	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	568	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	568	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	568	25	et	et	FW
10_1101-2021_02_13_429885	568	26	al	al	NNP
10_1101-2021_02_13_429885	568	27	.	.	.
10_1101-2021_02_13_429885	569	1	A	a	DT
10_1101-2021_02_13_429885	569	2	fully	fully	RB
10_1101-2021_02_13_429885	569	3	automated	automate	VBN
10_1101-2021_02_13_429885	569	4	approach	approach	NN
10_1101-2021_02_13_429885	569	5	for	for	IN
10_1101-2021_02_13_429885	569	6	quality	quality	NN
10_1101-2021_02_13_429885	569	7	control	control	NN
10_1101-2021_02_13_429885	569	8	of	of	IN
10_1101-2021_02_13_429885	569	9	cancer	cancer	NN
10_1101-2021_02_13_429885	569	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	569	11	in	in	IN
10_1101-2021_02_13_429885	569	12	the	the	DT
10_1101-2021_02_13_429885	569	13	era	era	NN
10_1101-2021_02_13_429885	569	14	of	of	IN
10_1101-2021_02_13_429885	569	15	high	high	JJ
10_1101-2021_02_13_429885	569	16	-	-	HYPH
10_1101-2021_02_13_429885	569	17	resolution	resolution	NN
10_1101-2021_02_13_429885	569	18	whole	whole	JJ
10_1101-2021_02_13_429885	569	19	genome	genome	JJ
10_1101-2021_02_13_429885	569	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	569	21	.	.	.
10_1101-2021_02_13_429885	570	1	Supplementary	Supplementary	NNP
10_1101-2021_02_13_429885	570	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	570	3	S5	s5	NN
10_1101-2021_02_13_429885	570	4	.	.	.
10_1101-2021_02_13_429885	571	1	​Colorectal	​colorectal	JJ
10_1101-2021_02_13_429885	571	2	multi	multi	JJ
10_1101-2021_02_13_429885	571	3	-	-	JJ
10_1101-2021_02_13_429885	571	4	region	region	JJ
10_1101-2021_02_13_429885	571	5	sample	sample	NN
10_1101-2021_02_13_429885	571	6	Set6_42	Set6_42	NNP
10_1101-2021_02_13_429885	571	7	for	for	IN
10_1101-2021_02_13_429885	571	8	patient	patient	NN
10_1101-2021_02_13_429885	571	9	Set6	Set6	NNP
10_1101-2021_02_13_429885	571	10	.	.	.
10_1101-2021_02_13_429885	572	1	​a	​a	NNS
10_1101-2021_02_13_429885	572	2	.	.	.
10_1101-2021_02_13_429885	573	1	Data	datum	NNS
10_1101-2021_02_13_429885	573	2	for	for	IN
10_1101-2021_02_13_429885	573	3	the	the	DT
10_1101-2021_02_13_429885	573	4	sample	sample	NN
10_1101-2021_02_13_429885	573	5	(	(	-LRB-
10_1101-2021_02_13_429885	573	6	genome	genome	NN
10_1101-2021_02_13_429885	573	7	-	-	HYPH
10_1101-2021_02_13_429885	573	8	wide	wide	JJ
10_1101-2021_02_13_429885	573	9	CNA	cna	NN
10_1101-2021_02_13_429885	573	10	segments	segment	NNS
10_1101-2021_02_13_429885	573	11	,	,	,
10_1101-2021_02_13_429885	573	12	CCF	CCF	NNP
10_1101-2021_02_13_429885	573	13	and	and	CC
10_1101-2021_02_13_429885	573	14	read	read	VBD
10_1101-2021_02_13_429885	573	15	counts	count	NNS
10_1101-2021_02_13_429885	573	16	distribution	distribution	NN
10_1101-2021_02_13_429885	573	17	)	)	-RRB-
10_1101-2021_02_13_429885	573	18	.	.	.
10_1101-2021_02_13_429885	574	1	b	b	LS
10_1101-2021_02_13_429885	574	2	,	,	,
10_1101-2021_02_13_429885	574	3	c.​	c.​	NNP
10_1101-2021_02_13_429885	574	4	Peak	Peak	NNP
10_1101-2021_02_13_429885	574	5	analysis	analysis	NN
10_1101-2021_02_13_429885	574	6	and	and	CC
10_1101-2021_02_13_429885	574	7	CCF	ccf	NN
10_1101-2021_02_13_429885	574	8	computation	computation	NN
10_1101-2021_02_13_429885	574	9	for	for	IN
10_1101-2021_02_13_429885	574	10	the	the	DT
10_1101-2021_02_13_429885	574	11	sample	sample	NN
10_1101-2021_02_13_429885	574	12	.	.	.
10_1101-2021_02_13_429885	575	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	575	2	-	-	:
10_1101-2021_02_13_429885	575	3	BY	by	IN
10_1101-2021_02_13_429885	575	4	-	-	HYPH
10_1101-2021_02_13_429885	575	5	NC	NC	NNP
10_1101-2021_02_13_429885	575	6	-	-	HYPH
10_1101-2021_02_13_429885	575	7	ND	ND	NNP
10_1101-2021_02_13_429885	575	8	4.0	4.0	CD
10_1101-2021_02_13_429885	575	9	International	International	NNP
10_1101-2021_02_13_429885	575	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	575	11	under	under	IN
10_1101-2021_02_13_429885	575	12	a	a	DT
10_1101-2021_02_13_429885	575	13	(	(	-LRB-
10_1101-2021_02_13_429885	575	14	which	which	WDT
10_1101-2021_02_13_429885	575	15	was	be	VBD
10_1101-2021_02_13_429885	575	16	not	not	RB
10_1101-2021_02_13_429885	575	17	certified	certify	VBN
10_1101-2021_02_13_429885	575	18	by	by	IN
10_1101-2021_02_13_429885	575	19	peer	peer	NN
10_1101-2021_02_13_429885	575	20	review	review	NN
10_1101-2021_02_13_429885	575	21	)	)	-RRB-
10_1101-2021_02_13_429885	575	22	is	be	VBZ
10_1101-2021_02_13_429885	575	23	the	the	DT
10_1101-2021_02_13_429885	575	24	author	author	NN
10_1101-2021_02_13_429885	575	25	/	/	SYM
10_1101-2021_02_13_429885	575	26	funder	funder	NN
10_1101-2021_02_13_429885	575	27	,	,	,
10_1101-2021_02_13_429885	575	28	who	who	WP
10_1101-2021_02_13_429885	575	29	has	have	VBZ
10_1101-2021_02_13_429885	575	30	granted	grant	VBN
10_1101-2021_02_13_429885	575	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	575	32	a	a	DT
10_1101-2021_02_13_429885	575	33	license	license	NN
10_1101-2021_02_13_429885	575	34	to	to	TO
10_1101-2021_02_13_429885	575	35	display	display	VB
10_1101-2021_02_13_429885	575	36	the	the	DT
10_1101-2021_02_13_429885	575	37	preprint	preprint	NN
10_1101-2021_02_13_429885	575	38	in	in	IN
10_1101-2021_02_13_429885	575	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	575	40	.	.	.
10_1101-2021_02_13_429885	576	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	576	2	is	be	VBZ
10_1101-2021_02_13_429885	576	3	made	make	VBN
10_1101-2021_02_13_429885	576	4	The	the	DT
10_1101-2021_02_13_429885	576	5	copyright	copyright	NN
10_1101-2021_02_13_429885	576	6	holder	holder	NN
10_1101-2021_02_13_429885	576	7	for	for	IN
10_1101-2021_02_13_429885	576	8	this	this	DT
10_1101-2021_02_13_429885	576	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	576	10	version	version	NN
10_1101-2021_02_13_429885	576	11	posted	post	VBD
10_1101-2021_02_13_429885	576	12	February	February	NNP
10_1101-2021_02_13_429885	576	13	13	13	CD
10_1101-2021_02_13_429885	576	14	,	,	,
10_1101-2021_02_13_429885	576	15	2021	2021	CD
10_1101-2021_02_13_429885	576	16	.	.	.
10_1101-2021_02_13_429885	576	17	;	;	:
10_1101-2021_02_13_429885	576	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	576	19	:	:	:
10_1101-2021_02_13_429885	576	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	576	21	preprint	preprint	NN
10_1101-2021_02_13_429885	576	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	576	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	576	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	576	25	et	et	FW
10_1101-2021_02_13_429885	576	26	al	al	NNP
10_1101-2021_02_13_429885	576	27	.	.	.
10_1101-2021_02_13_429885	577	1	A	a	DT
10_1101-2021_02_13_429885	577	2	fully	fully	RB
10_1101-2021_02_13_429885	577	3	automated	automate	VBN
10_1101-2021_02_13_429885	577	4	approach	approach	NN
10_1101-2021_02_13_429885	577	5	for	for	IN
10_1101-2021_02_13_429885	577	6	quality	quality	NN
10_1101-2021_02_13_429885	577	7	control	control	NN
10_1101-2021_02_13_429885	577	8	of	of	IN
10_1101-2021_02_13_429885	577	9	cancer	cancer	NN
10_1101-2021_02_13_429885	577	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	577	11	in	in	IN
10_1101-2021_02_13_429885	577	12	the	the	DT
10_1101-2021_02_13_429885	577	13	era	era	NN
10_1101-2021_02_13_429885	577	14	of	of	IN
10_1101-2021_02_13_429885	577	15	high	high	JJ
10_1101-2021_02_13_429885	577	16	-	-	HYPH
10_1101-2021_02_13_429885	577	17	resolution	resolution	NN
10_1101-2021_02_13_429885	577	18	whole	whole	JJ
10_1101-2021_02_13_429885	577	19	genome	genome	JJ
10_1101-2021_02_13_429885	577	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	577	21	.	.	.
10_1101-2021_02_13_429885	578	1	Supplementary	supplementary	JJ
10_1101-2021_02_13_429885	578	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	578	3	S6	s6	NN
10_1101-2021_02_13_429885	578	4	.	.	.
10_1101-2021_02_13_429885	579	1	​Colorectal	​colorectal	JJ
10_1101-2021_02_13_429885	579	2	multi	multi	JJ
10_1101-2021_02_13_429885	579	3	-	-	JJ
10_1101-2021_02_13_429885	579	4	region	region	JJ
10_1101-2021_02_13_429885	579	5	sample	sample	NN
10_1101-2021_02_13_429885	579	6	Set6_44	Set6_44	NNP
10_1101-2021_02_13_429885	579	7	for	for	IN
10_1101-2021_02_13_429885	579	8	patient	patient	NN
10_1101-2021_02_13_429885	579	9	Set6	Set6	NNP
10_1101-2021_02_13_429885	579	10	.	.	.
10_1101-2021_02_13_429885	580	1	​a	​a	NNS
10_1101-2021_02_13_429885	580	2	.	.	.
10_1101-2021_02_13_429885	581	1	Data	datum	NNS
10_1101-2021_02_13_429885	581	2	for	for	IN
10_1101-2021_02_13_429885	581	3	the	the	DT
10_1101-2021_02_13_429885	581	4	sample	sample	NN
10_1101-2021_02_13_429885	581	5	(	(	-LRB-
10_1101-2021_02_13_429885	581	6	genome	genome	NN
10_1101-2021_02_13_429885	581	7	-	-	HYPH
10_1101-2021_02_13_429885	581	8	wide	wide	JJ
10_1101-2021_02_13_429885	581	9	CNA	cna	NN
10_1101-2021_02_13_429885	581	10	segments	segment	NNS
10_1101-2021_02_13_429885	581	11	,	,	,
10_1101-2021_02_13_429885	581	12	CCF	CCF	NNP
10_1101-2021_02_13_429885	581	13	and	and	CC
10_1101-2021_02_13_429885	581	14	read	read	VBD
10_1101-2021_02_13_429885	581	15	counts	count	NNS
10_1101-2021_02_13_429885	581	16	distribution	distribution	NN
10_1101-2021_02_13_429885	581	17	)	)	-RRB-
10_1101-2021_02_13_429885	581	18	.	.	.
10_1101-2021_02_13_429885	582	1	b	b	LS
10_1101-2021_02_13_429885	582	2	,	,	,
10_1101-2021_02_13_429885	582	3	c.​	c.​	NNP
10_1101-2021_02_13_429885	582	4	Peak	Peak	NNP
10_1101-2021_02_13_429885	582	5	analysis	analysis	NN
10_1101-2021_02_13_429885	582	6	and	and	CC
10_1101-2021_02_13_429885	582	7	CCF	ccf	NN
10_1101-2021_02_13_429885	582	8	computation	computation	NN
10_1101-2021_02_13_429885	582	9	for	for	IN
10_1101-2021_02_13_429885	582	10	the	the	DT
10_1101-2021_02_13_429885	582	11	sample	sample	NN
10_1101-2021_02_13_429885	582	12	.	.	.
10_1101-2021_02_13_429885	583	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	583	2	-	-	:
10_1101-2021_02_13_429885	583	3	BY	by	IN
10_1101-2021_02_13_429885	583	4	-	-	HYPH
10_1101-2021_02_13_429885	583	5	NC	NC	NNP
10_1101-2021_02_13_429885	583	6	-	-	HYPH
10_1101-2021_02_13_429885	583	7	ND	ND	NNP
10_1101-2021_02_13_429885	583	8	4.0	4.0	CD
10_1101-2021_02_13_429885	583	9	International	International	NNP
10_1101-2021_02_13_429885	583	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	583	11	under	under	IN
10_1101-2021_02_13_429885	583	12	a	a	DT
10_1101-2021_02_13_429885	583	13	(	(	-LRB-
10_1101-2021_02_13_429885	583	14	which	which	WDT
10_1101-2021_02_13_429885	583	15	was	be	VBD
10_1101-2021_02_13_429885	583	16	not	not	RB
10_1101-2021_02_13_429885	583	17	certified	certify	VBN
10_1101-2021_02_13_429885	583	18	by	by	IN
10_1101-2021_02_13_429885	583	19	peer	peer	NN
10_1101-2021_02_13_429885	583	20	review	review	NN
10_1101-2021_02_13_429885	583	21	)	)	-RRB-
10_1101-2021_02_13_429885	583	22	is	be	VBZ
10_1101-2021_02_13_429885	583	23	the	the	DT
10_1101-2021_02_13_429885	583	24	author	author	NN
10_1101-2021_02_13_429885	583	25	/	/	SYM
10_1101-2021_02_13_429885	583	26	funder	funder	NN
10_1101-2021_02_13_429885	583	27	,	,	,
10_1101-2021_02_13_429885	583	28	who	who	WP
10_1101-2021_02_13_429885	583	29	has	have	VBZ
10_1101-2021_02_13_429885	583	30	granted	grant	VBN
10_1101-2021_02_13_429885	583	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	583	32	a	a	DT
10_1101-2021_02_13_429885	583	33	license	license	NN
10_1101-2021_02_13_429885	583	34	to	to	TO
10_1101-2021_02_13_429885	583	35	display	display	VB
10_1101-2021_02_13_429885	583	36	the	the	DT
10_1101-2021_02_13_429885	583	37	preprint	preprint	NN
10_1101-2021_02_13_429885	583	38	in	in	IN
10_1101-2021_02_13_429885	583	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	583	40	.	.	.
10_1101-2021_02_13_429885	584	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	584	2	is	be	VBZ
10_1101-2021_02_13_429885	584	3	made	make	VBN
10_1101-2021_02_13_429885	584	4	The	the	DT
10_1101-2021_02_13_429885	584	5	copyright	copyright	NN
10_1101-2021_02_13_429885	584	6	holder	holder	NN
10_1101-2021_02_13_429885	584	7	for	for	IN
10_1101-2021_02_13_429885	584	8	this	this	DT
10_1101-2021_02_13_429885	584	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	584	10	version	version	NN
10_1101-2021_02_13_429885	584	11	posted	post	VBD
10_1101-2021_02_13_429885	584	12	February	February	NNP
10_1101-2021_02_13_429885	584	13	13	13	CD
10_1101-2021_02_13_429885	584	14	,	,	,
10_1101-2021_02_13_429885	584	15	2021	2021	CD
10_1101-2021_02_13_429885	584	16	.	.	.
10_1101-2021_02_13_429885	584	17	;	;	:
10_1101-2021_02_13_429885	584	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	584	19	:	:	:
10_1101-2021_02_13_429885	584	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	584	21	preprint	preprint	NN
10_1101-2021_02_13_429885	584	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	584	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	584	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	584	25	et	et	FW
10_1101-2021_02_13_429885	584	26	al	al	NNP
10_1101-2021_02_13_429885	584	27	.	.	.
10_1101-2021_02_13_429885	585	1	A	a	DT
10_1101-2021_02_13_429885	585	2	fully	fully	RB
10_1101-2021_02_13_429885	585	3	automated	automate	VBN
10_1101-2021_02_13_429885	585	4	approach	approach	NN
10_1101-2021_02_13_429885	585	5	for	for	IN
10_1101-2021_02_13_429885	585	6	quality	quality	NN
10_1101-2021_02_13_429885	585	7	control	control	NN
10_1101-2021_02_13_429885	585	8	of	of	IN
10_1101-2021_02_13_429885	585	9	cancer	cancer	NN
10_1101-2021_02_13_429885	585	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	585	11	in	in	IN
10_1101-2021_02_13_429885	585	12	the	the	DT
10_1101-2021_02_13_429885	585	13	era	era	NN
10_1101-2021_02_13_429885	585	14	of	of	IN
10_1101-2021_02_13_429885	585	15	high	high	JJ
10_1101-2021_02_13_429885	585	16	-	-	HYPH
10_1101-2021_02_13_429885	585	17	resolution	resolution	NN
10_1101-2021_02_13_429885	585	18	whole	whole	JJ
10_1101-2021_02_13_429885	585	19	genome	genome	JJ
10_1101-2021_02_13_429885	585	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	585	21	.	.	.
10_1101-2021_02_13_429885	586	1	Supplementary	supplementary	JJ
10_1101-2021_02_13_429885	586	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	586	3	S7	S7	NNP
10_1101-2021_02_13_429885	586	4	.	.	.
10_1101-2021_02_13_429885	587	1	​Colorectal	​colorectal	JJ
10_1101-2021_02_13_429885	587	2	multi	multi	JJ
10_1101-2021_02_13_429885	587	3	-	-	JJ
10_1101-2021_02_13_429885	587	4	region	region	JJ
10_1101-2021_02_13_429885	587	5	sample	sample	NN
10_1101-2021_02_13_429885	587	6	Set6_45	Set6_45	NNP
10_1101-2021_02_13_429885	587	7	for	for	IN
10_1101-2021_02_13_429885	587	8	patient	patient	NN
10_1101-2021_02_13_429885	587	9	Set6	Set6	NNP
10_1101-2021_02_13_429885	587	10	.	.	.
10_1101-2021_02_13_429885	588	1	​a	​a	NNS
10_1101-2021_02_13_429885	588	2	.	.	.
10_1101-2021_02_13_429885	589	1	Data	datum	NNS
10_1101-2021_02_13_429885	589	2	for	for	IN
10_1101-2021_02_13_429885	589	3	the	the	DT
10_1101-2021_02_13_429885	589	4	sample	sample	NN
10_1101-2021_02_13_429885	589	5	(	(	-LRB-
10_1101-2021_02_13_429885	589	6	genome	genome	NN
10_1101-2021_02_13_429885	589	7	-	-	HYPH
10_1101-2021_02_13_429885	589	8	wide	wide	JJ
10_1101-2021_02_13_429885	589	9	CNA	cna	NN
10_1101-2021_02_13_429885	589	10	segments	segment	NNS
10_1101-2021_02_13_429885	589	11	,	,	,
10_1101-2021_02_13_429885	589	12	CCF	CCF	NNP
10_1101-2021_02_13_429885	589	13	and	and	CC
10_1101-2021_02_13_429885	589	14	read	read	VBD
10_1101-2021_02_13_429885	589	15	counts	count	NNS
10_1101-2021_02_13_429885	589	16	distribution	distribution	NN
10_1101-2021_02_13_429885	589	17	)	)	-RRB-
10_1101-2021_02_13_429885	589	18	.	.	.
10_1101-2021_02_13_429885	590	1	b	b	LS
10_1101-2021_02_13_429885	590	2	,	,	,
10_1101-2021_02_13_429885	590	3	c.​	c.​	NNP
10_1101-2021_02_13_429885	590	4	Peak	Peak	NNP
10_1101-2021_02_13_429885	590	5	analysis	analysis	NN
10_1101-2021_02_13_429885	590	6	and	and	CC
10_1101-2021_02_13_429885	590	7	CCF	ccf	NN
10_1101-2021_02_13_429885	590	8	computation	computation	NN
10_1101-2021_02_13_429885	590	9	for	for	IN
10_1101-2021_02_13_429885	590	10	the	the	DT
10_1101-2021_02_13_429885	590	11	sample	sample	NN
10_1101-2021_02_13_429885	590	12	.	.	.
10_1101-2021_02_13_429885	591	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	591	2	-	-	:
10_1101-2021_02_13_429885	591	3	BY	by	IN
10_1101-2021_02_13_429885	591	4	-	-	HYPH
10_1101-2021_02_13_429885	591	5	NC	NC	NNP
10_1101-2021_02_13_429885	591	6	-	-	HYPH
10_1101-2021_02_13_429885	591	7	ND	ND	NNP
10_1101-2021_02_13_429885	591	8	4.0	4.0	CD
10_1101-2021_02_13_429885	591	9	International	International	NNP
10_1101-2021_02_13_429885	591	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	591	11	under	under	IN
10_1101-2021_02_13_429885	591	12	a	a	DT
10_1101-2021_02_13_429885	591	13	(	(	-LRB-
10_1101-2021_02_13_429885	591	14	which	which	WDT
10_1101-2021_02_13_429885	591	15	was	be	VBD
10_1101-2021_02_13_429885	591	16	not	not	RB
10_1101-2021_02_13_429885	591	17	certified	certify	VBN
10_1101-2021_02_13_429885	591	18	by	by	IN
10_1101-2021_02_13_429885	591	19	peer	peer	NN
10_1101-2021_02_13_429885	591	20	review	review	NN
10_1101-2021_02_13_429885	591	21	)	)	-RRB-
10_1101-2021_02_13_429885	591	22	is	be	VBZ
10_1101-2021_02_13_429885	591	23	the	the	DT
10_1101-2021_02_13_429885	591	24	author	author	NN
10_1101-2021_02_13_429885	591	25	/	/	SYM
10_1101-2021_02_13_429885	591	26	funder	funder	NN
10_1101-2021_02_13_429885	591	27	,	,	,
10_1101-2021_02_13_429885	591	28	who	who	WP
10_1101-2021_02_13_429885	591	29	has	have	VBZ
10_1101-2021_02_13_429885	591	30	granted	grant	VBN
10_1101-2021_02_13_429885	591	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	591	32	a	a	DT
10_1101-2021_02_13_429885	591	33	license	license	NN
10_1101-2021_02_13_429885	591	34	to	to	TO
10_1101-2021_02_13_429885	591	35	display	display	VB
10_1101-2021_02_13_429885	591	36	the	the	DT
10_1101-2021_02_13_429885	591	37	preprint	preprint	NN
10_1101-2021_02_13_429885	591	38	in	in	IN
10_1101-2021_02_13_429885	591	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	591	40	.	.	.
10_1101-2021_02_13_429885	592	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	592	2	is	be	VBZ
10_1101-2021_02_13_429885	592	3	made	make	VBN
10_1101-2021_02_13_429885	592	4	The	the	DT
10_1101-2021_02_13_429885	592	5	copyright	copyright	NN
10_1101-2021_02_13_429885	592	6	holder	holder	NN
10_1101-2021_02_13_429885	592	7	for	for	IN
10_1101-2021_02_13_429885	592	8	this	this	DT
10_1101-2021_02_13_429885	592	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	592	10	version	version	NN
10_1101-2021_02_13_429885	592	11	posted	post	VBD
10_1101-2021_02_13_429885	592	12	February	February	NNP
10_1101-2021_02_13_429885	592	13	13	13	CD
10_1101-2021_02_13_429885	592	14	,	,	,
10_1101-2021_02_13_429885	592	15	2021	2021	CD
10_1101-2021_02_13_429885	592	16	.	.	.
10_1101-2021_02_13_429885	592	17	;	;	:
10_1101-2021_02_13_429885	592	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	592	19	:	:	:
10_1101-2021_02_13_429885	592	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	592	21	preprint	preprint	NN
10_1101-2021_02_13_429885	592	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	592	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	592	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	592	25	et	et	FW
10_1101-2021_02_13_429885	592	26	al	al	NNP
10_1101-2021_02_13_429885	592	27	.	.	.
10_1101-2021_02_13_429885	593	1	A	a	DT
10_1101-2021_02_13_429885	593	2	fully	fully	RB
10_1101-2021_02_13_429885	593	3	automated	automate	VBN
10_1101-2021_02_13_429885	593	4	approach	approach	NN
10_1101-2021_02_13_429885	593	5	for	for	IN
10_1101-2021_02_13_429885	593	6	quality	quality	NN
10_1101-2021_02_13_429885	593	7	control	control	NN
10_1101-2021_02_13_429885	593	8	of	of	IN
10_1101-2021_02_13_429885	593	9	cancer	cancer	NN
10_1101-2021_02_13_429885	593	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	593	11	in	in	IN
10_1101-2021_02_13_429885	593	12	the	the	DT
10_1101-2021_02_13_429885	593	13	era	era	NN
10_1101-2021_02_13_429885	593	14	of	of	IN
10_1101-2021_02_13_429885	593	15	high	high	JJ
10_1101-2021_02_13_429885	593	16	-	-	HYPH
10_1101-2021_02_13_429885	593	17	resolution	resolution	NN
10_1101-2021_02_13_429885	593	18	whole	whole	JJ
10_1101-2021_02_13_429885	593	19	genome	genome	JJ
10_1101-2021_02_13_429885	593	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	593	21	.	.	.
10_1101-2021_02_13_429885	594	1	Supplementary	Supplementary	NNP
10_1101-2021_02_13_429885	594	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	594	3	S8	S8	NNP
10_1101-2021_02_13_429885	594	4	.	.	.
10_1101-2021_02_13_429885	595	1	​Colorectal	​colorectal	JJ
10_1101-2021_02_13_429885	595	2	multi	multi	JJ
10_1101-2021_02_13_429885	595	3	-	-	JJ
10_1101-2021_02_13_429885	595	4	region	region	JJ
10_1101-2021_02_13_429885	595	5	sample	sample	NN
10_1101-2021_02_13_429885	595	6	Set6_46	Set6_46	NNP
10_1101-2021_02_13_429885	595	7	for	for	IN
10_1101-2021_02_13_429885	595	8	patient	patient	NN
10_1101-2021_02_13_429885	595	9	Set6	Set6	NNP
10_1101-2021_02_13_429885	595	10	.	.	.
10_1101-2021_02_13_429885	596	1	​a	​a	NNS
10_1101-2021_02_13_429885	596	2	.	.	.
10_1101-2021_02_13_429885	597	1	Data	datum	NNS
10_1101-2021_02_13_429885	597	2	for	for	IN
10_1101-2021_02_13_429885	597	3	the	the	DT
10_1101-2021_02_13_429885	597	4	sample	sample	NN
10_1101-2021_02_13_429885	597	5	(	(	-LRB-
10_1101-2021_02_13_429885	597	6	genome	genome	NN
10_1101-2021_02_13_429885	597	7	-	-	HYPH
10_1101-2021_02_13_429885	597	8	wide	wide	JJ
10_1101-2021_02_13_429885	597	9	CNA	cna	NN
10_1101-2021_02_13_429885	597	10	segments	segment	NNS
10_1101-2021_02_13_429885	597	11	,	,	,
10_1101-2021_02_13_429885	597	12	CCF	CCF	NNP
10_1101-2021_02_13_429885	597	13	and	and	CC
10_1101-2021_02_13_429885	597	14	read	read	VBD
10_1101-2021_02_13_429885	597	15	counts	count	NNS
10_1101-2021_02_13_429885	597	16	distribution	distribution	NN
10_1101-2021_02_13_429885	597	17	)	)	-RRB-
10_1101-2021_02_13_429885	597	18	.	.	.
10_1101-2021_02_13_429885	598	1	b	b	LS
10_1101-2021_02_13_429885	598	2	,	,	,
10_1101-2021_02_13_429885	598	3	c.​	c.​	NNP
10_1101-2021_02_13_429885	598	4	Peak	Peak	NNP
10_1101-2021_02_13_429885	598	5	analysis	analysis	NN
10_1101-2021_02_13_429885	598	6	and	and	CC
10_1101-2021_02_13_429885	598	7	CCF	ccf	NN
10_1101-2021_02_13_429885	598	8	computation	computation	NN
10_1101-2021_02_13_429885	598	9	for	for	IN
10_1101-2021_02_13_429885	598	10	the	the	DT
10_1101-2021_02_13_429885	598	11	sample	sample	NN
10_1101-2021_02_13_429885	598	12	.	.	.
10_1101-2021_02_13_429885	599	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	599	2	-	-	:
10_1101-2021_02_13_429885	599	3	BY	by	IN
10_1101-2021_02_13_429885	599	4	-	-	HYPH
10_1101-2021_02_13_429885	599	5	NC	NC	NNP
10_1101-2021_02_13_429885	599	6	-	-	HYPH
10_1101-2021_02_13_429885	599	7	ND	ND	NNP
10_1101-2021_02_13_429885	599	8	4.0	4.0	CD
10_1101-2021_02_13_429885	599	9	International	International	NNP
10_1101-2021_02_13_429885	599	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	599	11	under	under	IN
10_1101-2021_02_13_429885	599	12	a	a	DT
10_1101-2021_02_13_429885	599	13	(	(	-LRB-
10_1101-2021_02_13_429885	599	14	which	which	WDT
10_1101-2021_02_13_429885	599	15	was	be	VBD
10_1101-2021_02_13_429885	599	16	not	not	RB
10_1101-2021_02_13_429885	599	17	certified	certify	VBN
10_1101-2021_02_13_429885	599	18	by	by	IN
10_1101-2021_02_13_429885	599	19	peer	peer	NN
10_1101-2021_02_13_429885	599	20	review	review	NN
10_1101-2021_02_13_429885	599	21	)	)	-RRB-
10_1101-2021_02_13_429885	599	22	is	be	VBZ
10_1101-2021_02_13_429885	599	23	the	the	DT
10_1101-2021_02_13_429885	599	24	author	author	NN
10_1101-2021_02_13_429885	599	25	/	/	SYM
10_1101-2021_02_13_429885	599	26	funder	funder	NN
10_1101-2021_02_13_429885	599	27	,	,	,
10_1101-2021_02_13_429885	599	28	who	who	WP
10_1101-2021_02_13_429885	599	29	has	have	VBZ
10_1101-2021_02_13_429885	599	30	granted	grant	VBN
10_1101-2021_02_13_429885	599	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	599	32	a	a	DT
10_1101-2021_02_13_429885	599	33	license	license	NN
10_1101-2021_02_13_429885	599	34	to	to	TO
10_1101-2021_02_13_429885	599	35	display	display	VB
10_1101-2021_02_13_429885	599	36	the	the	DT
10_1101-2021_02_13_429885	599	37	preprint	preprint	NN
10_1101-2021_02_13_429885	599	38	in	in	IN
10_1101-2021_02_13_429885	599	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	599	40	.	.	.
10_1101-2021_02_13_429885	600	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	600	2	is	be	VBZ
10_1101-2021_02_13_429885	600	3	made	make	VBN
10_1101-2021_02_13_429885	600	4	The	the	DT
10_1101-2021_02_13_429885	600	5	copyright	copyright	NN
10_1101-2021_02_13_429885	600	6	holder	holder	NN
10_1101-2021_02_13_429885	600	7	for	for	IN
10_1101-2021_02_13_429885	600	8	this	this	DT
10_1101-2021_02_13_429885	600	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	600	10	version	version	NN
10_1101-2021_02_13_429885	600	11	posted	post	VBD
10_1101-2021_02_13_429885	600	12	February	February	NNP
10_1101-2021_02_13_429885	600	13	13	13	CD
10_1101-2021_02_13_429885	600	14	,	,	,
10_1101-2021_02_13_429885	600	15	2021	2021	CD
10_1101-2021_02_13_429885	600	16	.	.	.
10_1101-2021_02_13_429885	600	17	;	;	:
10_1101-2021_02_13_429885	600	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	600	19	:	:	:
10_1101-2021_02_13_429885	600	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	600	21	preprint	preprint	NN
10_1101-2021_02_13_429885	600	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	600	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	600	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	600	25	et	et	FW
10_1101-2021_02_13_429885	600	26	al	al	NNP
10_1101-2021_02_13_429885	600	27	.	.	.
10_1101-2021_02_13_429885	601	1	A	a	DT
10_1101-2021_02_13_429885	601	2	fully	fully	RB
10_1101-2021_02_13_429885	601	3	automated	automate	VBN
10_1101-2021_02_13_429885	601	4	approach	approach	NN
10_1101-2021_02_13_429885	601	5	for	for	IN
10_1101-2021_02_13_429885	601	6	quality	quality	NN
10_1101-2021_02_13_429885	601	7	control	control	NN
10_1101-2021_02_13_429885	601	8	of	of	IN
10_1101-2021_02_13_429885	601	9	cancer	cancer	NN
10_1101-2021_02_13_429885	601	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	601	11	in	in	IN
10_1101-2021_02_13_429885	601	12	the	the	DT
10_1101-2021_02_13_429885	601	13	era	era	NN
10_1101-2021_02_13_429885	601	14	of	of	IN
10_1101-2021_02_13_429885	601	15	high	high	JJ
10_1101-2021_02_13_429885	601	16	-	-	HYPH
10_1101-2021_02_13_429885	601	17	resolution	resolution	NN
10_1101-2021_02_13_429885	601	18	whole	whole	JJ
10_1101-2021_02_13_429885	601	19	genome	genome	JJ
10_1101-2021_02_13_429885	601	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	601	21	.	.	.
10_1101-2021_02_13_429885	602	1	Supplementary	supplementary	JJ
10_1101-2021_02_13_429885	602	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	602	3	S9	s9	NN
10_1101-2021_02_13_429885	602	4	.	.	.
10_1101-2021_02_13_429885	603	1	​Colorectal	​colorectal	JJ
10_1101-2021_02_13_429885	603	2	multi	multi	JJ
10_1101-2021_02_13_429885	603	3	-	-	JJ
10_1101-2021_02_13_429885	603	4	region	region	JJ
10_1101-2021_02_13_429885	603	5	sample	sample	NN
10_1101-2021_02_13_429885	603	6	Set6_47	Set6_47	NNP
10_1101-2021_02_13_429885	603	7	for	for	IN
10_1101-2021_02_13_429885	603	8	patient	patient	NN
10_1101-2021_02_13_429885	603	9	Set6	Set6	NNP
10_1101-2021_02_13_429885	603	10	.	.	.
10_1101-2021_02_13_429885	604	1	​a	​a	NNS
10_1101-2021_02_13_429885	604	2	.	.	.
10_1101-2021_02_13_429885	605	1	Data	datum	NNS
10_1101-2021_02_13_429885	605	2	for	for	IN
10_1101-2021_02_13_429885	605	3	the	the	DT
10_1101-2021_02_13_429885	605	4	sample	sample	NN
10_1101-2021_02_13_429885	605	5	(	(	-LRB-
10_1101-2021_02_13_429885	605	6	genome	genome	NN
10_1101-2021_02_13_429885	605	7	-	-	HYPH
10_1101-2021_02_13_429885	605	8	wide	wide	JJ
10_1101-2021_02_13_429885	605	9	CNA	cna	NN
10_1101-2021_02_13_429885	605	10	segments	segment	NNS
10_1101-2021_02_13_429885	605	11	,	,	,
10_1101-2021_02_13_429885	605	12	CCF	CCF	NNP
10_1101-2021_02_13_429885	605	13	and	and	CC
10_1101-2021_02_13_429885	605	14	read	read	VBD
10_1101-2021_02_13_429885	605	15	counts	count	NNS
10_1101-2021_02_13_429885	605	16	distribution	distribution	NN
10_1101-2021_02_13_429885	605	17	)	)	-RRB-
10_1101-2021_02_13_429885	605	18	.	.	.
10_1101-2021_02_13_429885	606	1	b	b	LS
10_1101-2021_02_13_429885	606	2	,	,	,
10_1101-2021_02_13_429885	606	3	c.​	c.​	NNP
10_1101-2021_02_13_429885	606	4	Peak	Peak	NNP
10_1101-2021_02_13_429885	606	5	analysis	analysis	NN
10_1101-2021_02_13_429885	606	6	and	and	CC
10_1101-2021_02_13_429885	606	7	CCF	ccf	NN
10_1101-2021_02_13_429885	606	8	computation	computation	NN
10_1101-2021_02_13_429885	606	9	for	for	IN
10_1101-2021_02_13_429885	606	10	the	the	DT
10_1101-2021_02_13_429885	606	11	sample	sample	NN
10_1101-2021_02_13_429885	606	12	.	.	.
10_1101-2021_02_13_429885	607	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	607	2	-	-	:
10_1101-2021_02_13_429885	607	3	BY	by	IN
10_1101-2021_02_13_429885	607	4	-	-	HYPH
10_1101-2021_02_13_429885	607	5	NC	NC	NNP
10_1101-2021_02_13_429885	607	6	-	-	HYPH
10_1101-2021_02_13_429885	607	7	ND	ND	NNP
10_1101-2021_02_13_429885	607	8	4.0	4.0	CD
10_1101-2021_02_13_429885	607	9	International	International	NNP
10_1101-2021_02_13_429885	607	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	607	11	under	under	IN
10_1101-2021_02_13_429885	607	12	a	a	DT
10_1101-2021_02_13_429885	607	13	(	(	-LRB-
10_1101-2021_02_13_429885	607	14	which	which	WDT
10_1101-2021_02_13_429885	607	15	was	be	VBD
10_1101-2021_02_13_429885	607	16	not	not	RB
10_1101-2021_02_13_429885	607	17	certified	certify	VBN
10_1101-2021_02_13_429885	607	18	by	by	IN
10_1101-2021_02_13_429885	607	19	peer	peer	NN
10_1101-2021_02_13_429885	607	20	review	review	NN
10_1101-2021_02_13_429885	607	21	)	)	-RRB-
10_1101-2021_02_13_429885	607	22	is	be	VBZ
10_1101-2021_02_13_429885	607	23	the	the	DT
10_1101-2021_02_13_429885	607	24	author	author	NN
10_1101-2021_02_13_429885	607	25	/	/	SYM
10_1101-2021_02_13_429885	607	26	funder	funder	NN
10_1101-2021_02_13_429885	607	27	,	,	,
10_1101-2021_02_13_429885	607	28	who	who	WP
10_1101-2021_02_13_429885	607	29	has	have	VBZ
10_1101-2021_02_13_429885	607	30	granted	grant	VBN
10_1101-2021_02_13_429885	607	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	607	32	a	a	DT
10_1101-2021_02_13_429885	607	33	license	license	NN
10_1101-2021_02_13_429885	607	34	to	to	TO
10_1101-2021_02_13_429885	607	35	display	display	VB
10_1101-2021_02_13_429885	607	36	the	the	DT
10_1101-2021_02_13_429885	607	37	preprint	preprint	NN
10_1101-2021_02_13_429885	607	38	in	in	IN
10_1101-2021_02_13_429885	607	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	607	40	.	.	.
10_1101-2021_02_13_429885	608	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	608	2	is	be	VBZ
10_1101-2021_02_13_429885	608	3	made	make	VBN
10_1101-2021_02_13_429885	608	4	The	the	DT
10_1101-2021_02_13_429885	608	5	copyright	copyright	NN
10_1101-2021_02_13_429885	608	6	holder	holder	NN
10_1101-2021_02_13_429885	608	7	for	for	IN
10_1101-2021_02_13_429885	608	8	this	this	DT
10_1101-2021_02_13_429885	608	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	608	10	version	version	NN
10_1101-2021_02_13_429885	608	11	posted	post	VBD
10_1101-2021_02_13_429885	608	12	February	February	NNP
10_1101-2021_02_13_429885	608	13	13	13	CD
10_1101-2021_02_13_429885	608	14	,	,	,
10_1101-2021_02_13_429885	608	15	2021	2021	CD
10_1101-2021_02_13_429885	608	16	.	.	.
10_1101-2021_02_13_429885	608	17	;	;	:
10_1101-2021_02_13_429885	608	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	608	19	:	:	:
10_1101-2021_02_13_429885	608	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	608	21	preprint	preprint	NN
10_1101-2021_02_13_429885	608	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	608	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	608	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	608	25	et	et	FW
10_1101-2021_02_13_429885	608	26	al	al	NNP
10_1101-2021_02_13_429885	608	27	.	.	.
10_1101-2021_02_13_429885	609	1	A	a	DT
10_1101-2021_02_13_429885	609	2	fully	fully	RB
10_1101-2021_02_13_429885	609	3	automated	automate	VBN
10_1101-2021_02_13_429885	609	4	approach	approach	NN
10_1101-2021_02_13_429885	609	5	for	for	IN
10_1101-2021_02_13_429885	609	6	quality	quality	NN
10_1101-2021_02_13_429885	609	7	control	control	NN
10_1101-2021_02_13_429885	609	8	of	of	IN
10_1101-2021_02_13_429885	609	9	cancer	cancer	NN
10_1101-2021_02_13_429885	609	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	609	11	in	in	IN
10_1101-2021_02_13_429885	609	12	the	the	DT
10_1101-2021_02_13_429885	609	13	era	era	NN
10_1101-2021_02_13_429885	609	14	of	of	IN
10_1101-2021_02_13_429885	609	15	high	high	JJ
10_1101-2021_02_13_429885	609	16	-	-	HYPH
10_1101-2021_02_13_429885	609	17	resolution	resolution	NN
10_1101-2021_02_13_429885	609	18	whole	whole	JJ
10_1101-2021_02_13_429885	609	19	genome	genome	JJ
10_1101-2021_02_13_429885	609	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	609	21	.	.	.
10_1101-2021_02_13_429885	610	1	Supplementary	supplementary	JJ
10_1101-2021_02_13_429885	610	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	610	3	S10	S10	NNP
10_1101-2021_02_13_429885	610	4	.	.	.
10_1101-2021_02_13_429885	611	1	​Colorectal	​colorectal	JJ
10_1101-2021_02_13_429885	611	2	multi	multi	JJ
10_1101-2021_02_13_429885	611	3	-	-	JJ
10_1101-2021_02_13_429885	611	4	region	region	JJ
10_1101-2021_02_13_429885	611	5	sample	sample	NN
10_1101-2021_02_13_429885	611	6	Set6_48	Set6_48	NNP
10_1101-2021_02_13_429885	611	7	for	for	IN
10_1101-2021_02_13_429885	611	8	patient	patient	NN
10_1101-2021_02_13_429885	611	9	Set6	Set6	NNP
10_1101-2021_02_13_429885	611	10	.	.	.
10_1101-2021_02_13_429885	612	1	a.	a.	NN
10_1101-2021_02_13_429885	613	1	​Data	​Data	NNP
10_1101-2021_02_13_429885	613	2	for	for	IN
10_1101-2021_02_13_429885	613	3	the	the	DT
10_1101-2021_02_13_429885	613	4	sample	sample	NN
10_1101-2021_02_13_429885	613	5	(	(	-LRB-
10_1101-2021_02_13_429885	613	6	genome	genome	NN
10_1101-2021_02_13_429885	613	7	-	-	HYPH
10_1101-2021_02_13_429885	613	8	wide	wide	JJ
10_1101-2021_02_13_429885	613	9	CNA	cna	NN
10_1101-2021_02_13_429885	613	10	segments	segment	NNS
10_1101-2021_02_13_429885	613	11	,	,	,
10_1101-2021_02_13_429885	613	12	CCF	CCF	NNP
10_1101-2021_02_13_429885	613	13	and	and	CC
10_1101-2021_02_13_429885	613	14	read	read	VBD
10_1101-2021_02_13_429885	613	15	counts	count	NNS
10_1101-2021_02_13_429885	613	16	distribution	distribution	NN
10_1101-2021_02_13_429885	613	17	)	)	-RRB-
10_1101-2021_02_13_429885	613	18	.	.	.
10_1101-2021_02_13_429885	614	1	​b	​b	NNP
10_1101-2021_02_13_429885	614	2	,	,	,
10_1101-2021_02_13_429885	614	3	c.​	c.​	NNP
10_1101-2021_02_13_429885	614	4	Peak	Peak	NNP
10_1101-2021_02_13_429885	614	5	analysis	analysis	NN
10_1101-2021_02_13_429885	614	6	and	and	CC
10_1101-2021_02_13_429885	614	7	CCF	ccf	NN
10_1101-2021_02_13_429885	614	8	computation	computation	NN
10_1101-2021_02_13_429885	614	9	for	for	IN
10_1101-2021_02_13_429885	614	10	the	the	DT
10_1101-2021_02_13_429885	614	11	sample	sample	NN
10_1101-2021_02_13_429885	614	12	.	.	.
10_1101-2021_02_13_429885	615	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	615	2	-	-	:
10_1101-2021_02_13_429885	615	3	BY	by	IN
10_1101-2021_02_13_429885	615	4	-	-	HYPH
10_1101-2021_02_13_429885	615	5	NC	NC	NNP
10_1101-2021_02_13_429885	615	6	-	-	HYPH
10_1101-2021_02_13_429885	615	7	ND	ND	NNP
10_1101-2021_02_13_429885	615	8	4.0	4.0	CD
10_1101-2021_02_13_429885	615	9	International	International	NNP
10_1101-2021_02_13_429885	615	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	615	11	under	under	IN
10_1101-2021_02_13_429885	615	12	a	a	DT
10_1101-2021_02_13_429885	615	13	(	(	-LRB-
10_1101-2021_02_13_429885	615	14	which	which	WDT
10_1101-2021_02_13_429885	615	15	was	be	VBD
10_1101-2021_02_13_429885	615	16	not	not	RB
10_1101-2021_02_13_429885	615	17	certified	certify	VBN
10_1101-2021_02_13_429885	615	18	by	by	IN
10_1101-2021_02_13_429885	615	19	peer	peer	NN
10_1101-2021_02_13_429885	615	20	review	review	NN
10_1101-2021_02_13_429885	615	21	)	)	-RRB-
10_1101-2021_02_13_429885	615	22	is	be	VBZ
10_1101-2021_02_13_429885	615	23	the	the	DT
10_1101-2021_02_13_429885	615	24	author	author	NN
10_1101-2021_02_13_429885	615	25	/	/	SYM
10_1101-2021_02_13_429885	615	26	funder	funder	NN
10_1101-2021_02_13_429885	615	27	,	,	,
10_1101-2021_02_13_429885	615	28	who	who	WP
10_1101-2021_02_13_429885	615	29	has	have	VBZ
10_1101-2021_02_13_429885	615	30	granted	grant	VBN
10_1101-2021_02_13_429885	615	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	615	32	a	a	DT
10_1101-2021_02_13_429885	615	33	license	license	NN
10_1101-2021_02_13_429885	615	34	to	to	TO
10_1101-2021_02_13_429885	615	35	display	display	VB
10_1101-2021_02_13_429885	615	36	the	the	DT
10_1101-2021_02_13_429885	615	37	preprint	preprint	NN
10_1101-2021_02_13_429885	615	38	in	in	IN
10_1101-2021_02_13_429885	615	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	615	40	.	.	.
10_1101-2021_02_13_429885	616	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	616	2	is	be	VBZ
10_1101-2021_02_13_429885	616	3	made	make	VBN
10_1101-2021_02_13_429885	616	4	The	the	DT
10_1101-2021_02_13_429885	616	5	copyright	copyright	NN
10_1101-2021_02_13_429885	616	6	holder	holder	NN
10_1101-2021_02_13_429885	616	7	for	for	IN
10_1101-2021_02_13_429885	616	8	this	this	DT
10_1101-2021_02_13_429885	616	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	616	10	version	version	NN
10_1101-2021_02_13_429885	616	11	posted	post	VBD
10_1101-2021_02_13_429885	616	12	February	February	NNP
10_1101-2021_02_13_429885	616	13	13	13	CD
10_1101-2021_02_13_429885	616	14	,	,	,
10_1101-2021_02_13_429885	616	15	2021	2021	CD
10_1101-2021_02_13_429885	616	16	.	.	.
10_1101-2021_02_13_429885	616	17	;	;	:
10_1101-2021_02_13_429885	616	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	616	19	:	:	:
10_1101-2021_02_13_429885	616	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	616	21	preprint	preprint	NN
10_1101-2021_02_13_429885	616	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	616	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	616	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	616	25	et	et	FW
10_1101-2021_02_13_429885	616	26	al	al	NNP
10_1101-2021_02_13_429885	616	27	.	.	.
10_1101-2021_02_13_429885	617	1	A	a	DT
10_1101-2021_02_13_429885	617	2	fully	fully	RB
10_1101-2021_02_13_429885	617	3	automated	automate	VBN
10_1101-2021_02_13_429885	617	4	approach	approach	NN
10_1101-2021_02_13_429885	617	5	for	for	IN
10_1101-2021_02_13_429885	617	6	quality	quality	NN
10_1101-2021_02_13_429885	617	7	control	control	NN
10_1101-2021_02_13_429885	617	8	of	of	IN
10_1101-2021_02_13_429885	617	9	cancer	cancer	NN
10_1101-2021_02_13_429885	617	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	617	11	in	in	IN
10_1101-2021_02_13_429885	617	12	the	the	DT
10_1101-2021_02_13_429885	617	13	era	era	NN
10_1101-2021_02_13_429885	617	14	of	of	IN
10_1101-2021_02_13_429885	617	15	high	high	JJ
10_1101-2021_02_13_429885	617	16	-	-	HYPH
10_1101-2021_02_13_429885	617	17	resolution	resolution	NN
10_1101-2021_02_13_429885	617	18	whole	whole	JJ
10_1101-2021_02_13_429885	617	19	genome	genome	JJ
10_1101-2021_02_13_429885	617	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	617	21	.	.	.
10_1101-2021_02_13_429885	618	1	Supplementary	Supplementary	NNP
10_1101-2021_02_13_429885	618	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	618	3	11	11	CD
10_1101-2021_02_13_429885	618	4	.	.	.
10_1101-2021_02_13_429885	619	1	​Example	​Example	NNP
10_1101-2021_02_13_429885	619	2	PCAWG	PCAWG	NNP
10_1101-2021_02_13_429885	619	3	sample	sample	NN
10_1101-2021_02_13_429885	619	4	with	with	IN
10_1101-2021_02_13_429885	619	5	purity	purity	NN
10_1101-2021_02_13_429885	619	6	of	of	IN
10_1101-2021_02_13_429885	619	7	100	100	CD
10_1101-2021_02_13_429885	619	8	%	%	NN
10_1101-2021_02_13_429885	619	9	.	.	.
10_1101-2021_02_13_429885	620	1	​a	​a	NNS
10_1101-2021_02_13_429885	620	2	.	.	.
10_1101-2021_02_13_429885	621	1	​Data	​Data	NNP
10_1101-2021_02_13_429885	621	2	for	for	IN
10_1101-2021_02_13_429885	621	3	the	the	DT
10_1101-2021_02_13_429885	621	4	sample	sample	NN
10_1101-2021_02_13_429885	621	5	(	(	-LRB-
10_1101-2021_02_13_429885	621	6	genome	genome	NN
10_1101-2021_02_13_429885	621	7	-	-	HYPH
10_1101-2021_02_13_429885	621	8	wide	wide	JJ
10_1101-2021_02_13_429885	621	9	CNA	cna	NN
10_1101-2021_02_13_429885	621	10	segments	segment	NNS
10_1101-2021_02_13_429885	621	11	,	,	,
10_1101-2021_02_13_429885	621	12	CCF	CCF	NNP
10_1101-2021_02_13_429885	621	13	and	and	CC
10_1101-2021_02_13_429885	621	14	read	read	VBD
10_1101-2021_02_13_429885	621	15	counts	count	NNS
10_1101-2021_02_13_429885	621	16	distribution	distribution	NN
10_1101-2021_02_13_429885	621	17	)	)	-RRB-
10_1101-2021_02_13_429885	621	18	.	.	.
10_1101-2021_02_13_429885	622	1	​b	​b	NNP
10_1101-2021_02_13_429885	622	2	.	.	.
10_1101-2021_02_13_429885	623	1	This	this	DT
10_1101-2021_02_13_429885	623	2	sample	sample	NN
10_1101-2021_02_13_429885	623	3	has	have	VBZ
10_1101-2021_02_13_429885	623	4	75	75	CD
10_1101-2021_02_13_429885	623	5	%	%	NN
10_1101-2021_02_13_429885	623	6	of	of	IN
10_1101-2021_02_13_429885	623	7	its	-PRON-	PRP$
10_1101-2021_02_13_429885	623	8	SNVs	SNVs	NNP
10_1101-2021_02_13_429885	623	9	in	in	IN
10_1101-2021_02_13_429885	623	10	diploid	diploid	JJ
10_1101-2021_02_13_429885	623	11	tumour	tumour	NN
10_1101-2021_02_13_429885	623	12	regions	region	NNS
10_1101-2021_02_13_429885	623	13	,	,	,
10_1101-2021_02_13_429885	623	14	where	where	WRB
10_1101-2021_02_13_429885	623	15	a	a	DT
10_1101-2021_02_13_429885	623	16	small	small	JJ
10_1101-2021_02_13_429885	623	17	peak	peak	NN
10_1101-2021_02_13_429885	623	18	is	be	VBZ
10_1101-2021_02_13_429885	623	19	detectable	detectable	JJ
10_1101-2021_02_13_429885	623	20	at	at	IN
10_1101-2021_02_13_429885	623	21	the	the	DT
10_1101-2021_02_13_429885	623	22	expected	expected	JJ
10_1101-2021_02_13_429885	623	23	purity	purity	NN
10_1101-2021_02_13_429885	623	24	.	.	.
10_1101-2021_02_13_429885	624	1	The	the	DT
10_1101-2021_02_13_429885	624	2	VAF	VAF	NNP
10_1101-2021_02_13_429885	624	3	clearly	clearly	RB
10_1101-2021_02_13_429885	624	4	peaks	peak	VBZ
10_1101-2021_02_13_429885	624	5	at	at	IN
10_1101-2021_02_13_429885	624	6	~10	~10	NNP
10_1101-2021_02_13_429885	624	7	%	%	NN
10_1101-2021_02_13_429885	624	8	,	,	,
10_1101-2021_02_13_429885	624	9	possibly	possibly	RB
10_1101-2021_02_13_429885	624	10	suggesting	suggest	VBG
10_1101-2021_02_13_429885	624	11	a	a	DT
10_1101-2021_02_13_429885	624	12	purity	purity	NN
10_1101-2021_02_13_429885	624	13	of	of	IN
10_1101-2021_02_13_429885	624	14	20	20	CD
10_1101-2021_02_13_429885	624	15	%	%	NN
10_1101-2021_02_13_429885	624	16	or	or	CC
10_1101-2021_02_13_429885	624	17	lower	low	JJR
10_1101-2021_02_13_429885	624	18	,	,	,
10_1101-2021_02_13_429885	624	19	rather	rather	RB
10_1101-2021_02_13_429885	624	20	than	than	IN
10_1101-2021_02_13_429885	624	21	100	100	CD
10_1101-2021_02_13_429885	624	22	%	%	NN
10_1101-2021_02_13_429885	624	23	.	.	.
10_1101-2021_02_13_429885	625	1	Further	further	JJ
10_1101-2021_02_13_429885	625	2	doubts	doubt	NNS
10_1101-2021_02_13_429885	625	3	about	about	IN
10_1101-2021_02_13_429885	625	4	the	the	DT
10_1101-2021_02_13_429885	625	5	current	current	JJ
10_1101-2021_02_13_429885	625	6	purity	purity	NN
10_1101-2021_02_13_429885	625	7	come	come	VBP
10_1101-2021_02_13_429885	625	8	from	from	IN
10_1101-2021_02_13_429885	625	9	non	non	JJ
10_1101-2021_02_13_429885	625	10	-	-	JJ
10_1101-2021_02_13_429885	625	11	diploid	diploid	JJ
10_1101-2021_02_13_429885	625	12	regions	region	NNS
10_1101-2021_02_13_429885	625	13	,	,	,
10_1101-2021_02_13_429885	625	14	where	where	WRB
10_1101-2021_02_13_429885	625	15	all	all	DT
10_1101-2021_02_13_429885	625	16	peaks	peak	NNS
10_1101-2021_02_13_429885	625	17	are	be	VBP
10_1101-2021_02_13_429885	625	18	mismatched	mismatch	VBN
10_1101-2021_02_13_429885	625	19	;	;	:
10_1101-2021_02_13_429885	625	20	for	for	IN
10_1101-2021_02_13_429885	625	21	this	this	DT
10_1101-2021_02_13_429885	625	22	sample	sample	NN
10_1101-2021_02_13_429885	625	23	CNAs	cna	NNS
10_1101-2021_02_13_429885	625	24	called	call	VBD
10_1101-2021_02_13_429885	625	25	with	with	IN
10_1101-2021_02_13_429885	625	26	a	a	DT
10_1101-2021_02_13_429885	625	27	low	low	JJ
10_1101-2021_02_13_429885	625	28	-	-	HYPH
10_1101-2021_02_13_429885	625	29	purity	purity	NN
10_1101-2021_02_13_429885	625	30	solution	solution	NN
10_1101-2021_02_13_429885	625	31	should	should	MD
10_1101-2021_02_13_429885	625	32	be	be	VB
10_1101-2021_02_13_429885	625	33	compared	compare	VBN
10_1101-2021_02_13_429885	625	34	to	to	IN
10_1101-2021_02_13_429885	625	35	the	the	DT
10_1101-2021_02_13_429885	625	36	100	100	CD
10_1101-2021_02_13_429885	625	37	%	%	NN
10_1101-2021_02_13_429885	625	38	purity	purity	NN
10_1101-2021_02_13_429885	625	39	solution	solution	NN
10_1101-2021_02_13_429885	625	40	.	.	.
10_1101-2021_02_13_429885	626	1	​c	​c	NNP
10_1101-2021_02_13_429885	626	2	.	.	.
10_1101-2021_02_13_429885	627	1	CCF	ccf	NN
10_1101-2021_02_13_429885	627	2	computation	computation	NN
10_1101-2021_02_13_429885	627	3	for	for	IN
10_1101-2021_02_13_429885	627	4	the	the	DT
10_1101-2021_02_13_429885	627	5	sample	sample	NN
10_1101-2021_02_13_429885	627	6	.	.	.
10_1101-2021_02_13_429885	628	1	Notice	notice	VB
10_1101-2021_02_13_429885	628	2	that	that	IN
10_1101-2021_02_13_429885	628	3	in	in	IN
10_1101-2021_02_13_429885	628	4	triploid	triploid	JJ
10_1101-2021_02_13_429885	628	5	and	and	CC
10_1101-2021_02_13_429885	628	6	tetraploid	tetraploid	JJ
10_1101-2021_02_13_429885	628	7	tumour	tumour	NN
10_1101-2021_02_13_429885	628	8	genomes	genome	NNS
10_1101-2021_02_13_429885	628	9	we	-PRON-	PRP
10_1101-2021_02_13_429885	628	10	do	do	VBP
10_1101-2021_02_13_429885	628	11	not	not	RB
10_1101-2021_02_13_429885	628	12	find	find	VB
10_1101-2021_02_13_429885	628	13	mutations	mutation	NNS
10_1101-2021_02_13_429885	628	14	present	present	JJ
10_1101-2021_02_13_429885	628	15	in	in	IN
10_1101-2021_02_13_429885	628	16	2	2	CD
10_1101-2021_02_13_429885	628	17	copies	copy	NNS
10_1101-2021_02_13_429885	628	18	.	.	.
10_1101-2021_02_13_429885	629	1	Was	be	VBD
10_1101-2021_02_13_429885	629	2	this	this	DT
10_1101-2021_02_13_429885	629	3	true	true	JJ
10_1101-2021_02_13_429885	629	4	then	then	RB
10_1101-2021_02_13_429885	629	5	the	the	DT
10_1101-2021_02_13_429885	629	6	tumour	tumour	NN
10_1101-2021_02_13_429885	629	7	did	do	VBD
10_1101-2021_02_13_429885	629	8	not	not	RB
10_1101-2021_02_13_429885	629	9	acquire	acquire	VB
10_1101-2021_02_13_429885	629	10	any	any	DT
10_1101-2021_02_13_429885	629	11	SNV	SNV	NNP
10_1101-2021_02_13_429885	629	12	right	right	RB
10_1101-2021_02_13_429885	629	13	before	before	IN
10_1101-2021_02_13_429885	629	14	the	the	DT
10_1101-2021_02_13_429885	629	15	CNA	CNA	NNP
10_1101-2021_02_13_429885	629	16	.	.	.
10_1101-2021_02_13_429885	630	1	Also	also	RB
10_1101-2021_02_13_429885	630	2	,	,	,
10_1101-2021_02_13_429885	630	3	here	here	RB
10_1101-2021_02_13_429885	630	4	we	-PRON-	PRP
10_1101-2021_02_13_429885	630	5	are	be	VBP
10_1101-2021_02_13_429885	630	6	not	not	RB
10_1101-2021_02_13_429885	630	7	cross	cross	JJ
10_1101-2021_02_13_429885	630	8	-	-	JJ
10_1101-2021_02_13_429885	630	9	checking	checking	JJ
10_1101-2021_02_13_429885	630	10	QC	QC	NNP
10_1101-2021_02_13_429885	630	11	results	result	NNS
10_1101-2021_02_13_429885	630	12	from	from	IN
10_1101-2021_02_13_429885	630	13	peak	peak	NN
10_1101-2021_02_13_429885	630	14	.CC	.CC	:
10_1101-2021_02_13_429885	630	15	-	-	:
10_1101-2021_02_13_429885	630	16	BY	by	IN
10_1101-2021_02_13_429885	630	17	-	-	HYPH
10_1101-2021_02_13_429885	630	18	NC	NC	NNP
10_1101-2021_02_13_429885	630	19	-	-	HYPH
10_1101-2021_02_13_429885	630	20	ND	ND	NNP
10_1101-2021_02_13_429885	630	21	4.0	4.0	CD
10_1101-2021_02_13_429885	630	22	International	International	NNP
10_1101-2021_02_13_429885	630	23	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	630	24	under	under	IN
10_1101-2021_02_13_429885	630	25	a	a	DT
10_1101-2021_02_13_429885	630	26	(	(	-LRB-
10_1101-2021_02_13_429885	630	27	which	which	WDT
10_1101-2021_02_13_429885	630	28	was	be	VBD
10_1101-2021_02_13_429885	630	29	not	not	RB
10_1101-2021_02_13_429885	630	30	certified	certify	VBN
10_1101-2021_02_13_429885	630	31	by	by	IN
10_1101-2021_02_13_429885	630	32	peer	peer	NN
10_1101-2021_02_13_429885	630	33	review	review	NN
10_1101-2021_02_13_429885	630	34	)	)	-RRB-
10_1101-2021_02_13_429885	630	35	is	be	VBZ
10_1101-2021_02_13_429885	630	36	the	the	DT
10_1101-2021_02_13_429885	630	37	author	author	NN
10_1101-2021_02_13_429885	630	38	/	/	SYM
10_1101-2021_02_13_429885	630	39	funder	funder	NN
10_1101-2021_02_13_429885	630	40	,	,	,
10_1101-2021_02_13_429885	630	41	who	who	WP
10_1101-2021_02_13_429885	630	42	has	have	VBZ
10_1101-2021_02_13_429885	630	43	granted	grant	VBN
10_1101-2021_02_13_429885	630	44	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	630	45	a	a	DT
10_1101-2021_02_13_429885	630	46	license	license	NN
10_1101-2021_02_13_429885	630	47	to	to	TO
10_1101-2021_02_13_429885	630	48	display	display	VB
10_1101-2021_02_13_429885	630	49	the	the	DT
10_1101-2021_02_13_429885	630	50	preprint	preprint	NN
10_1101-2021_02_13_429885	630	51	in	in	IN
10_1101-2021_02_13_429885	630	52	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	630	53	.	.	.
10_1101-2021_02_13_429885	631	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	631	2	is	be	VBZ
10_1101-2021_02_13_429885	631	3	made	make	VBN
10_1101-2021_02_13_429885	631	4	The	the	DT
10_1101-2021_02_13_429885	631	5	copyright	copyright	NN
10_1101-2021_02_13_429885	631	6	holder	holder	NN
10_1101-2021_02_13_429885	631	7	for	for	IN
10_1101-2021_02_13_429885	631	8	this	this	DT
10_1101-2021_02_13_429885	631	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	631	10	version	version	NN
10_1101-2021_02_13_429885	631	11	posted	post	VBD
10_1101-2021_02_13_429885	631	12	February	February	NNP
10_1101-2021_02_13_429885	631	13	13	13	CD
10_1101-2021_02_13_429885	631	14	,	,	,
10_1101-2021_02_13_429885	631	15	2021	2021	CD
10_1101-2021_02_13_429885	631	16	.	.	.
10_1101-2021_02_13_429885	631	17	;	;	:
10_1101-2021_02_13_429885	631	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	631	19	:	:	:
10_1101-2021_02_13_429885	631	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	631	21	preprint	preprint	NN
10_1101-2021_02_13_429885	631	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	631	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	631	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	631	25	et	et	FW
10_1101-2021_02_13_429885	631	26	al	al	NNP
10_1101-2021_02_13_429885	631	27	.	.	.
10_1101-2021_02_13_429885	632	1	A	a	DT
10_1101-2021_02_13_429885	632	2	fully	fully	RB
10_1101-2021_02_13_429885	632	3	automated	automate	VBN
10_1101-2021_02_13_429885	632	4	approach	approach	NN
10_1101-2021_02_13_429885	632	5	for	for	IN
10_1101-2021_02_13_429885	632	6	quality	quality	NN
10_1101-2021_02_13_429885	632	7	control	control	NN
10_1101-2021_02_13_429885	632	8	of	of	IN
10_1101-2021_02_13_429885	632	9	cancer	cancer	NN
10_1101-2021_02_13_429885	632	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	632	11	in	in	IN
10_1101-2021_02_13_429885	632	12	the	the	DT
10_1101-2021_02_13_429885	632	13	era	era	NN
10_1101-2021_02_13_429885	632	14	of	of	IN
10_1101-2021_02_13_429885	632	15	high	high	JJ
10_1101-2021_02_13_429885	632	16	-	-	HYPH
10_1101-2021_02_13_429885	632	17	resolution	resolution	NN
10_1101-2021_02_13_429885	632	18	whole	whole	JJ
10_1101-2021_02_13_429885	632	19	genome	genome	JJ
10_1101-2021_02_13_429885	632	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	632	21	.	.	.
10_1101-2021_02_13_429885	633	1	detection	detection	NN
10_1101-2021_02_13_429885	633	2	;	;	:
10_1101-2021_02_13_429885	633	3	for	for	IN
10_1101-2021_02_13_429885	633	4	instance	instance	NN
10_1101-2021_02_13_429885	633	5	we	-PRON-	PRP
10_1101-2021_02_13_429885	633	6	could	could	MD
10_1101-2021_02_13_429885	633	7	decide	decide	VB
10_1101-2021_02_13_429885	633	8	to	to	TO
10_1101-2021_02_13_429885	633	9	use	use	VB
10_1101-2021_02_13_429885	633	10	only	only	JJ
10_1101-2021_02_13_429885	633	11	mutations	mutation	NNS
10_1101-2021_02_13_429885	633	12	that	that	WDT
10_1101-2021_02_13_429885	633	13	map	map	VBP
10_1101-2021_02_13_429885	633	14	to	to	IN
10_1101-2021_02_13_429885	633	15	PASS	PASS	NNP
10_1101-2021_02_13_429885	633	16	states	state	NNS
10_1101-2021_02_13_429885	633	17	(	(	-LRB-
10_1101-2021_02_13_429885	633	18	1:1	1:1	CD
10_1101-2021_02_13_429885	633	19	,	,	,
10_1101-2021_02_13_429885	633	20	2:2	2:2	CD
10_1101-2021_02_13_429885	633	21	)	)	-RRB-
10_1101-2021_02_13_429885	633	22	,	,	,
10_1101-2021_02_13_429885	633	23	and	and	CC
10_1101-2021_02_13_429885	633	24	reject	reject	VBP
10_1101-2021_02_13_429885	633	25	all	all	DT
10_1101-2021_02_13_429885	633	26	others	other	NNS
10_1101-2021_02_13_429885	633	27	.	.	.
10_1101-2021_02_13_429885	634	1	Supplementary	Supplementary	NNP
10_1101-2021_02_13_429885	634	2	Figure	Figure	NNP
10_1101-2021_02_13_429885	634	3	12	12	CD
10_1101-2021_02_13_429885	634	4	.	.	.
10_1101-2021_02_13_429885	635	1	​Example	​Example	NNP
10_1101-2021_02_13_429885	635	2	PCAWG	PCAWG	NNP
10_1101-2021_02_13_429885	635	3	pancreatic	pancreatic	JJ
10_1101-2021_02_13_429885	635	4	adenocarcinoma	adenocarcinoma	NN
10_1101-2021_02_13_429885	635	5	with	with	IN
10_1101-2021_02_13_429885	635	6	99	99	CD
10_1101-2021_02_13_429885	635	7	%	%	NN
10_1101-2021_02_13_429885	635	8	purity	purity	NN
10_1101-2021_02_13_429885	635	9	(	(	-LRB-
10_1101-2021_02_13_429885	635	10	and	and	CC
10_1101-2021_02_13_429885	635	11	3	3	CD
10_1101-2021_02_13_429885	635	12	possible	possible	JJ
10_1101-2021_02_13_429885	635	13	driver	driver	NN
10_1101-2021_02_13_429885	635	14	SNVs	snv	NNS
10_1101-2021_02_13_429885	635	15	,	,	,
10_1101-2021_02_13_429885	635	16	2	2	CD
10_1101-2021_02_13_429885	635	17	of	of	IN
10_1101-2021_02_13_429885	635	18	them	-PRON-	PRP
10_1101-2021_02_13_429885	635	19	involving	involve	VBG
10_1101-2021_02_13_429885	635	20	tumour	tumour	NN
10_1101-2021_02_13_429885	635	21	suppressor	suppressor	NN
10_1101-2021_02_13_429885	635	22	genes	gene	NNS
10_1101-2021_02_13_429885	635	23	in	in	IN
10_1101-2021_02_13_429885	635	24	LOH	LOH	NNP
10_1101-2021_02_13_429885	635	25	regions	region	NNS
10_1101-2021_02_13_429885	635	26	)	)	-RRB-
10_1101-2021_02_13_429885	635	27	.	.	.
10_1101-2021_02_13_429885	636	1	​a	​a	NNS
10_1101-2021_02_13_429885	636	2	.	.	.
10_1101-2021_02_13_429885	637	1	​Data	​Data	NNP
10_1101-2021_02_13_429885	637	2	for	for	IN
10_1101-2021_02_13_429885	637	3	the	the	DT
10_1101-2021_02_13_429885	637	4	sample	sample	NN
10_1101-2021_02_13_429885	637	5	(	(	-LRB-
10_1101-2021_02_13_429885	637	6	genome	genome	NN
10_1101-2021_02_13_429885	637	7	-	-	HYPH
10_1101-2021_02_13_429885	637	8	wide	wide	JJ
10_1101-2021_02_13_429885	637	9	CNA	cna	NN
10_1101-2021_02_13_429885	637	10	segments	segment	NNS
10_1101-2021_02_13_429885	637	11	,	,	,
10_1101-2021_02_13_429885	637	12	CCF	CCF	NNP
10_1101-2021_02_13_429885	637	13	and	and	CC
10_1101-2021_02_13_429885	637	14	read	read	VBD
10_1101-2021_02_13_429885	637	15	counts	count	NNS
10_1101-2021_02_13_429885	637	16	distribution	distribution	NN
10_1101-2021_02_13_429885	637	17	)	)	-RRB-
10_1101-2021_02_13_429885	637	18	.	.	.
10_1101-2021_02_13_429885	638	1	​b	​b	NNP
10_1101-2021_02_13_429885	638	2	.	.	.
10_1101-2021_02_13_429885	639	1	This	this	DT
10_1101-2021_02_13_429885	639	2	sample	sample	NN
10_1101-2021_02_13_429885	639	3	has	have	VBZ
10_1101-2021_02_13_429885	639	4	90	90	CD
10_1101-2021_02_13_429885	639	5	%	%	NN
10_1101-2021_02_13_429885	639	6	of	of	IN
10_1101-2021_02_13_429885	639	7	its	-PRON-	PRP$
10_1101-2021_02_13_429885	639	8	SNVs	SNVs	NNP
10_1101-2021_02_13_429885	639	9	in	in	IN
10_1101-2021_02_13_429885	639	10	diploid	diploid	JJ
10_1101-2021_02_13_429885	639	11	tumour	tumour	NN
10_1101-2021_02_13_429885	639	12	regions	region	NNS
10_1101-2021_02_13_429885	639	13	,	,	,
10_1101-2021_02_13_429885	639	14	and	and	CC
10_1101-2021_02_13_429885	639	15	the	the	DT
10_1101-2021_02_13_429885	639	16	others	other	NNS
10_1101-2021_02_13_429885	639	17	in	in	IN
10_1101-2021_02_13_429885	639	18	a	a	DT
10_1101-2021_02_13_429885	639	19	variety	variety	NN
10_1101-2021_02_13_429885	639	20	of	of	IN
10_1101-2021_02_13_429885	639	21	distinct	distinct	JJ
10_1101-2021_02_13_429885	639	22	CNA	CNA	NNP
10_1101-2021_02_13_429885	639	23	segments	segment	NNS
10_1101-2021_02_13_429885	639	24	.	.	.
10_1101-2021_02_13_429885	640	1	From	from	IN
10_1101-2021_02_13_429885	640	2	a	a	DT
10_1101-2021_02_13_429885	640	3	peak	peak	NN
10_1101-2021_02_13_429885	640	4	analysis	analysis	NN
10_1101-2021_02_13_429885	640	5	point	point	NN
10_1101-2021_02_13_429885	640	6	of	of	IN
10_1101-2021_02_13_429885	640	7	view	view	NN
10_1101-2021_02_13_429885	640	8	,	,	,
10_1101-2021_02_13_429885	640	9	all	all	PDT
10_1101-2021_02_13_429885	640	10	the	the	DT
10_1101-2021_02_13_429885	640	11	calls	call	NNS
10_1101-2021_02_13_429885	640	12	are	be	VBP
10_1101-2021_02_13_429885	640	13	validated	validate	VBN
10_1101-2021_02_13_429885	640	14	.	.	.
10_1101-2021_02_13_429885	641	1	​c.​	​c.​	NNP
10_1101-2021_02_13_429885	641	2	CCF	ccf	NN
10_1101-2021_02_13_429885	641	3	values	value	NNS
10_1101-2021_02_13_429885	641	4	for	for	IN
10_1101-2021_02_13_429885	641	5	this	this	DT
10_1101-2021_02_13_429885	641	6	sample	sample	NN
10_1101-2021_02_13_429885	641	7	are	be	VBP
10_1101-2021_02_13_429885	641	8	also	also	RB
10_1101-2021_02_13_429885	641	9	good	good	JJ
10_1101-2021_02_13_429885	641	10	.	.	.
10_1101-2021_02_13_429885	642	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	642	2	-	-	:
10_1101-2021_02_13_429885	642	3	BY	by	IN
10_1101-2021_02_13_429885	642	4	-	-	HYPH
10_1101-2021_02_13_429885	642	5	NC	NC	NNP
10_1101-2021_02_13_429885	642	6	-	-	HYPH
10_1101-2021_02_13_429885	642	7	ND	ND	NNP
10_1101-2021_02_13_429885	642	8	4.0	4.0	CD
10_1101-2021_02_13_429885	642	9	International	International	NNP
10_1101-2021_02_13_429885	642	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	642	11	under	under	IN
10_1101-2021_02_13_429885	642	12	a	a	DT
10_1101-2021_02_13_429885	642	13	(	(	-LRB-
10_1101-2021_02_13_429885	642	14	which	which	WDT
10_1101-2021_02_13_429885	642	15	was	be	VBD
10_1101-2021_02_13_429885	642	16	not	not	RB
10_1101-2021_02_13_429885	642	17	certified	certify	VBN
10_1101-2021_02_13_429885	642	18	by	by	IN
10_1101-2021_02_13_429885	642	19	peer	peer	NN
10_1101-2021_02_13_429885	642	20	review	review	NN
10_1101-2021_02_13_429885	642	21	)	)	-RRB-
10_1101-2021_02_13_429885	642	22	is	be	VBZ
10_1101-2021_02_13_429885	642	23	the	the	DT
10_1101-2021_02_13_429885	642	24	author	author	NN
10_1101-2021_02_13_429885	642	25	/	/	SYM
10_1101-2021_02_13_429885	642	26	funder	funder	NN
10_1101-2021_02_13_429885	642	27	,	,	,
10_1101-2021_02_13_429885	642	28	who	who	WP
10_1101-2021_02_13_429885	642	29	has	have	VBZ
10_1101-2021_02_13_429885	642	30	granted	grant	VBN
10_1101-2021_02_13_429885	642	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	642	32	a	a	DT
10_1101-2021_02_13_429885	642	33	license	license	NN
10_1101-2021_02_13_429885	642	34	to	to	TO
10_1101-2021_02_13_429885	642	35	display	display	VB
10_1101-2021_02_13_429885	642	36	the	the	DT
10_1101-2021_02_13_429885	642	37	preprint	preprint	NN
10_1101-2021_02_13_429885	642	38	in	in	IN
10_1101-2021_02_13_429885	642	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	642	40	.	.	.
10_1101-2021_02_13_429885	643	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	643	2	is	be	VBZ
10_1101-2021_02_13_429885	643	3	made	make	VBN
10_1101-2021_02_13_429885	643	4	The	the	DT
10_1101-2021_02_13_429885	643	5	copyright	copyright	NN
10_1101-2021_02_13_429885	643	6	holder	holder	NN
10_1101-2021_02_13_429885	643	7	for	for	IN
10_1101-2021_02_13_429885	643	8	this	this	DT
10_1101-2021_02_13_429885	643	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	643	10	version	version	NN
10_1101-2021_02_13_429885	643	11	posted	post	VBD
10_1101-2021_02_13_429885	643	12	February	February	NNP
10_1101-2021_02_13_429885	643	13	13	13	CD
10_1101-2021_02_13_429885	643	14	,	,	,
10_1101-2021_02_13_429885	643	15	2021	2021	CD
10_1101-2021_02_13_429885	643	16	.	.	.
10_1101-2021_02_13_429885	643	17	;	;	:
10_1101-2021_02_13_429885	643	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	643	19	:	:	:
10_1101-2021_02_13_429885	643	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	643	21	preprint	preprint	NN
10_1101-2021_02_13_429885	643	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	643	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2021_02_13_429885	643	24	Househam	Househam	NNP
10_1101-2021_02_13_429885	643	25	et	et	FW
10_1101-2021_02_13_429885	643	26	al	al	NNP
10_1101-2021_02_13_429885	643	27	.	.	.
10_1101-2021_02_13_429885	644	1	A	a	DT
10_1101-2021_02_13_429885	644	2	fully	fully	RB
10_1101-2021_02_13_429885	644	3	automated	automate	VBN
10_1101-2021_02_13_429885	644	4	approach	approach	NN
10_1101-2021_02_13_429885	644	5	for	for	IN
10_1101-2021_02_13_429885	644	6	quality	quality	NN
10_1101-2021_02_13_429885	644	7	control	control	NN
10_1101-2021_02_13_429885	644	8	of	of	IN
10_1101-2021_02_13_429885	644	9	cancer	cancer	NN
10_1101-2021_02_13_429885	644	10	mutations	mutation	NNS
10_1101-2021_02_13_429885	644	11	in	in	IN
10_1101-2021_02_13_429885	644	12	the	the	DT
10_1101-2021_02_13_429885	644	13	era	era	NN
10_1101-2021_02_13_429885	644	14	of	of	IN
10_1101-2021_02_13_429885	644	15	high	high	JJ
10_1101-2021_02_13_429885	644	16	-	-	HYPH
10_1101-2021_02_13_429885	644	17	resolution	resolution	NN
10_1101-2021_02_13_429885	644	18	whole	whole	JJ
10_1101-2021_02_13_429885	644	19	genome	genome	JJ
10_1101-2021_02_13_429885	644	20	sequencing	sequencing	NN
10_1101-2021_02_13_429885	644	21	.	.	.
10_1101-2021_02_13_429885	645	1	.CC	.CC	NFP
10_1101-2021_02_13_429885	645	2	-	-	:
10_1101-2021_02_13_429885	645	3	BY	by	IN
10_1101-2021_02_13_429885	645	4	-	-	HYPH
10_1101-2021_02_13_429885	645	5	NC	NC	NNP
10_1101-2021_02_13_429885	645	6	-	-	HYPH
10_1101-2021_02_13_429885	645	7	ND	ND	NNP
10_1101-2021_02_13_429885	645	8	4.0	4.0	CD
10_1101-2021_02_13_429885	645	9	International	International	NNP
10_1101-2021_02_13_429885	645	10	licenseavailable	licenseavailable	NN
10_1101-2021_02_13_429885	645	11	under	under	IN
10_1101-2021_02_13_429885	645	12	a	a	DT
10_1101-2021_02_13_429885	645	13	(	(	-LRB-
10_1101-2021_02_13_429885	645	14	which	which	WDT
10_1101-2021_02_13_429885	645	15	was	be	VBD
10_1101-2021_02_13_429885	645	16	not	not	RB
10_1101-2021_02_13_429885	645	17	certified	certify	VBN
10_1101-2021_02_13_429885	645	18	by	by	IN
10_1101-2021_02_13_429885	645	19	peer	peer	NN
10_1101-2021_02_13_429885	645	20	review	review	NN
10_1101-2021_02_13_429885	645	21	)	)	-RRB-
10_1101-2021_02_13_429885	645	22	is	be	VBZ
10_1101-2021_02_13_429885	645	23	the	the	DT
10_1101-2021_02_13_429885	645	24	author	author	NN
10_1101-2021_02_13_429885	645	25	/	/	SYM
10_1101-2021_02_13_429885	645	26	funder	funder	NN
10_1101-2021_02_13_429885	645	27	,	,	,
10_1101-2021_02_13_429885	645	28	who	who	WP
10_1101-2021_02_13_429885	645	29	has	have	VBZ
10_1101-2021_02_13_429885	645	30	granted	grant	VBN
10_1101-2021_02_13_429885	645	31	bioRxiv	biorxiv	IN
10_1101-2021_02_13_429885	645	32	a	a	DT
10_1101-2021_02_13_429885	645	33	license	license	NN
10_1101-2021_02_13_429885	645	34	to	to	TO
10_1101-2021_02_13_429885	645	35	display	display	VB
10_1101-2021_02_13_429885	645	36	the	the	DT
10_1101-2021_02_13_429885	645	37	preprint	preprint	NN
10_1101-2021_02_13_429885	645	38	in	in	IN
10_1101-2021_02_13_429885	645	39	perpetuity	perpetuity	NN
10_1101-2021_02_13_429885	645	40	.	.	.
10_1101-2021_02_13_429885	646	1	It	-PRON-	PRP
10_1101-2021_02_13_429885	646	2	is	be	VBZ
10_1101-2021_02_13_429885	646	3	made	make	VBN
10_1101-2021_02_13_429885	646	4	The	the	DT
10_1101-2021_02_13_429885	646	5	copyright	copyright	NN
10_1101-2021_02_13_429885	646	6	holder	holder	NN
10_1101-2021_02_13_429885	646	7	for	for	IN
10_1101-2021_02_13_429885	646	8	this	this	DT
10_1101-2021_02_13_429885	646	9	preprintthis	preprintthis	NN
10_1101-2021_02_13_429885	646	10	version	version	NN
10_1101-2021_02_13_429885	646	11	posted	post	VBD
10_1101-2021_02_13_429885	646	12	February	February	NNP
10_1101-2021_02_13_429885	646	13	13	13	CD
10_1101-2021_02_13_429885	646	14	,	,	,
10_1101-2021_02_13_429885	646	15	2021	2021	CD
10_1101-2021_02_13_429885	646	16	.	.	.
10_1101-2021_02_13_429885	646	17	;	;	:
10_1101-2021_02_13_429885	646	18	https://doi.org/10.1101/2021.02.13.429885doi	https://doi.org/10.1101/2021.02.13.429885doi	ADD
10_1101-2021_02_13_429885	646	19	:	:	:
10_1101-2021_02_13_429885	646	20	bioRxiv	biorxiv	VB
10_1101-2021_02_13_429885	646	21	preprint	preprint	NN
10_1101-2021_02_13_429885	646	22	https://doi.org/10.1101/2021.02.13.429885	https://doi.org/10.1101/2021.02.13.429885	ADD
10_1101-2021_02_13_429885	646	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD