id author title date pages extension mime words sentences flesch summary cache txt 10_1101-2021_02_12_430963 Gerber, Stefan Streamlining differential exon and 3' UTR usage with diffUTR 2021 17 .pdf application/pdf 6710 896 62 adenylation site databases to enable differential 3' UTR usage analysis. Conclusions: diffUTR enables differential 3' UTR analysis and more generally facilitates DEU9 Popular bin-based DEU methods are provided by the limma [25,24], edgeR [23] and DEXSeq [22]41 Bins are prepared from various types of gene annotations as well as, optionally, additional APA-driven segmentation and extension, then read counts among statistically-significant genes, especially for bins with a higher expression (Figure 3A).78 diffUTR provides three main plot types to explore differential bin usage analyses, each with a88 Plotted are the UTR bins found statistically significant (binand gene-level FDR deuBinPlot (Figure 4B) provides bin-level statistic plots for a given gene, similar to those99 than CDS bins, including counts of 3' UTR when calculating overall gene expression could under-121 diffUTR streamlines DEU analysis and outperforms alternative methods in inferring UTR changes,127 For differential UTR analysis, gene-level results are ob-206 ./cache/10_1101-2021_02_12_430963.pdf ./txt/10_1101-2021_02_12_430963.txt