id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
10_1101-2021_02_12_430830	Gergely, Tibély	Simultaneous estimation of per cell division mutation rate and turnover rate from bulk tumor sequence data	2021	19	.pdf	application/pdf	8181	793	68	Simultaneous estimation of per cell division mutation rate and turnover rate from bulk tumor sequence data widely available bulk sequencing data where mutations from individual cells are and genomic mutation rate from bulk sequencing data. based on the maximum likelihood estimation of the parameters of a generative model of tumor growth and mutations. human hepatocellular carcinoma sample reveals an elevated per cell division mutation rate and high cell turnover. Due to the limitations of bulk sequencing, which only essays mutation frequencies for a population of cells from each tumor sample and does not The estimation is based on a maximum likelihood fit of the parameters of a birth-death model to the measured mutant and be estimated from readcount data, to separate the effects of the mutation rate We use pre-generated division trees from the ELynx suite at predetermined turnover rate values. Using the turnover rate, we also estimated the number of cell	./cache/10_1101-2021_02_12_430830.pdf	./txt/10_1101-2021_02_12_430830.txt