id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
10_1101-2021_02_12_430739	Malekian, Negin	Mutations in bdcA and valS correlate with quinolone resistance in wastewater Escherichia Coli	2021	13	.pdf	application/pdf	7516	1093	70	Mutations in bdcA and valS correlate with quinolone resistance in wastewater Escherichia Coli Here, we systematically screen for candidate quinolone resistance-conferring mutations. coli and performed a genome-wide association study (GWAS) correlating over 200,000 mutations against quinolone resistance phenotypes. significant mutations including one located at the active site of the biofilm dispersal genes bdcA and six silent In summary, we demonstrate that GWAS effectively and comprehensively identifies resistance mutations Keywords: E Coli; Quinolone; Antibiotic Resistance; Genome-Wide Association Study (GWAS) direct route to resistance is mutations in the drug targets gyrA and parC. In summary, we aim to show that a bacterial genomewide association study can effectively and comprehensively identify targets relevant to antibiotic resistance. Based on representative resistance phenotypes, the authors selected 103 isolates for sequencing with Illumina MiSeq, 92 of which are available from coli bdcA may act indirectly on antibiotic resistance.	./cache/10_1101-2021_02_12_430739.pdf	./txt/10_1101-2021_02_12_430739.txt