id author title date pages extension mime words sentences flesch summary cache txt 10_1101-2020_09_21_305516 Nikolic, Ana Copy-scAT: Deconvoluting single-cell chromatin accessibility of genetic subclones in cancer 2021 32 .pdf application/pdf 10376 1280 67 Copy-scAT: Deconvoluting single-cell chromatin accessibility of genetic subclones in cancer 1 Copy-scAT: Deconvoluting single-cell chromatin accessibility of genetic subclones in cancer 1 uses single-cell epigenomic data to infer copy number variants (CNVs) that define cancer cells. We have tested the ability of Copy-scAT to use scATAC data to call CNVs with three different approaches 100 genome sequencing (WGS) data for adult GBM (aGBM) surgical resections (n = 4 samples, 3,647 cells). adult GBM samples identified using both methods, versus total numbers of gains detected by scATAC or 160 Number of chromosome-arm level gains detected in adult GBM samples identified using both methods, 163 (c) Multiple myeloma samples were profiled by both scATAC and the single-cell CNV assay. chromosome-arm level gains detected in adult GBM samples identified using both methods, versus total 166 CNVs are detected in scATAC clusters with Copy-scAT in pediatric GBM samples. ./cache/10_1101-2020_09_21_305516.pdf ./txt/10_1101-2020_09_21_305516.txt