id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_xudgnhl6arhx3okho6t3uidjmq	G Chen	Translational research in bipolar disorder: emerging insights from genetically based models	2010	13	.pdf	application/pdf	12029	3500	74	Bipolar disorder (BPD) is characterized by vulnerability to episodic depression and mania and association studies, the list of risk genes for BPD is growing rapidly, creating an and monitor phenotypes related to mania, depression and mood swing vulnerability in Keywords: mania; depression; bipolar disorder; animal model; lithium that induces specific behavior(s) thought to crossspecies phenocopy one or a few mood symptoms (for studied using batteries of behavioral tests for phenocopies related to different components of BPD. and strong associations between BPD risk and polymorphisms of ERK pathway-modulating genes, such animal models target these behaviors and are sensitive to chronic or repeated treatment with antidepressants, including the learned helplessness Many candidate genes are being studied in antidepressant-sensitive behavioral paradigms or animal recurrence of depression,68 response to antidepressants,68–70 increased risk for BPD71 and symptoms of Translational research in bipolar disorder: emerging insights from genetically based models Translational research in bipolar disorder: emerging insights from genetically based models	./cache/work_xudgnhl6arhx3okho6t3uidjmq.pdf	./txt/work_xudgnhl6arhx3okho6t3uidjmq.txt