id author title date pages extension mime words sentences flesch summary cache txt work_722xdgw27rb7lbvdn64b4csupa DANIEL J. SAFER DESIGN AND REPORTING MODIFICATIONS IN INDUSTRY-SPONSORED COMPARATIVE PSYCHOPHARMACOLOGY TRIALS 2002 10 .pdf application/pdf 8378 772 61 The resulting publication of pharmaceutical company–sponsored comparative drug research now occupies a big share of the medical literature. industry-sponsored studies now dominate the comparative drug trial literature (Angell, 2001; Davidoff, 2002). At least eight studies sponsored by three different drug companies have compared their second-generation neuroleptic drug to a In comparative studies between second-generation neuroleptics, unusually high fixed or average doses of In studies of risperidone versus placebo and haloperidol, drug company–sponsored researchers utilized the industry-sponsored comparative drug trials, "perhaps industry studies "showing a superior effect of the sponsor's drug may be the result of scores of analyses As an example, in the placebo-controlled clinical trial comparing the effect of two antidepressants with each other to reduce anxiety symptoms, with haloperidol in short-term drug company–sponsored clinical trials of so-called treatment-resistant risperidone suggested that these drugs were as effective with treatment-resistant patients as clozapine, the ./cache/work_722xdgw27rb7lbvdn64b4csupa.pdf ./txt/work_722xdgw27rb7lbvdn64b4csupa.txt