id sid tid token lemma pos work_zhhbvy463fhkbjyzltzpvocafu 1 1 A a DT work_zhhbvy463fhkbjyzltzpvocafu 1 2 De De NNP work_zhhbvy463fhkbjyzltzpvocafu 1 3 Novo Novo NNP work_zhhbvy463fhkbjyzltzpvocafu 1 4 Novel Novel NNP work_zhhbvy463fhkbjyzltzpvocafu 1 5 Mutation Mutation NNP work_zhhbvy463fhkbjyzltzpvocafu 1 6 of of IN work_zhhbvy463fhkbjyzltzpvocafu 1 7 the the DT work_zhhbvy463fhkbjyzltzpvocafu 1 8 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 1 9 Gene Gene NNP work_zhhbvy463fhkbjyzltzpvocafu 1 10 in in IN work_zhhbvy463fhkbjyzltzpvocafu 1 11 a a DT work_zhhbvy463fhkbjyzltzpvocafu 1 12 Taiwanese taiwanese JJ work_zhhbvy463fhkbjyzltzpvocafu 1 13 Boy Boy NNP work_zhhbvy463fhkbjyzltzpvocafu 1 14 with with IN work_zhhbvy463fhkbjyzltzpvocafu 1 15 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 1 16 Disease Disease NNP work_zhhbvy463fhkbjyzltzpvocafu 1 17 349J 349J NNP work_zhhbvy463fhkbjyzltzpvocafu 1 18 Formos Formos NNP work_zhhbvy463fhkbjyzltzpvocafu 1 19 Med Med NNP work_zhhbvy463fhkbjyzltzpvocafu 1 20 Assoc Assoc NNP work_zhhbvy463fhkbjyzltzpvocafu 1 21 | | CD work_zhhbvy463fhkbjyzltzpvocafu 1 22 2006 2006 CD work_zhhbvy463fhkbjyzltzpvocafu 1 23 • • NNP work_zhhbvy463fhkbjyzltzpvocafu 1 24 Vol Vol NNP work_zhhbvy463fhkbjyzltzpvocafu 1 25 105 105 CD work_zhhbvy463fhkbjyzltzpvocafu 1 26 • • NNP work_zhhbvy463fhkbjyzltzpvocafu 1 27 No no DT work_zhhbvy463fhkbjyzltzpvocafu 1 28 4 4 CD work_zhhbvy463fhkbjyzltzpvocafu 1 29 EDNRB ednrb NN work_zhhbvy463fhkbjyzltzpvocafu 1 30 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 1 31 in in IN work_zhhbvy463fhkbjyzltzpvocafu 1 32 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 1 33 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 1 34 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 1 35 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 1 36 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 1 37 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 1 38 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 1 39 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 1 40 a a DT work_zhhbvy463fhkbjyzltzpvocafu 1 41 congenital congenital JJ work_zhhbvy463fhkbjyzltzpvocafu 1 42 disorder disorder NN work_zhhbvy463fhkbjyzltzpvocafu 1 43 characterized characterize VBN work_zhhbvy463fhkbjyzltzpvocafu 1 44 by by IN work_zhhbvy463fhkbjyzltzpvocafu 1 45 an an DT work_zhhbvy463fhkbjyzltzpvocafu 1 46 absence absence NN work_zhhbvy463fhkbjyzltzpvocafu 1 47 of of IN work_zhhbvy463fhkbjyzltzpvocafu 1 48 ganglion ganglion NN work_zhhbvy463fhkbjyzltzpvocafu 1 49 cells cell NNS work_zhhbvy463fhkbjyzltzpvocafu 1 50 in in IN work_zhhbvy463fhkbjyzltzpvocafu 1 51 the the DT work_zhhbvy463fhkbjyzltzpvocafu 1 52 nerve nerve NN work_zhhbvy463fhkbjyzltzpvocafu 1 53 plexuses plexus NNS work_zhhbvy463fhkbjyzltzpvocafu 1 54 of of IN work_zhhbvy463fhkbjyzltzpvocafu 1 55 the the DT work_zhhbvy463fhkbjyzltzpvocafu 1 56 lower low JJR work_zhhbvy463fhkbjyzltzpvocafu 1 57 digestive digestive JJ work_zhhbvy463fhkbjyzltzpvocafu 1 58 tract tract NN work_zhhbvy463fhkbjyzltzpvocafu 1 59 . . . work_zhhbvy463fhkbjyzltzpvocafu 2 1 Although although IN work_zhhbvy463fhkbjyzltzpvocafu 2 2 mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 2 3 in in IN work_zhhbvy463fhkbjyzltzpvocafu 2 4 eight eight CD work_zhhbvy463fhkbjyzltzpvocafu 2 5 different different JJ work_zhhbvy463fhkbjyzltzpvocafu 2 6 genes gene NNS work_zhhbvy463fhkbjyzltzpvocafu 2 7 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 2 8 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 2 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 2 10 EDN3 EDN3 NNP work_zhhbvy463fhkbjyzltzpvocafu 2 11 , , , work_zhhbvy463fhkbjyzltzpvocafu 2 12 ECE1 ECE1 NNP work_zhhbvy463fhkbjyzltzpvocafu 2 13 , , , work_zhhbvy463fhkbjyzltzpvocafu 2 14 SOX10 SOX10 NNP work_zhhbvy463fhkbjyzltzpvocafu 2 15 , , , work_zhhbvy463fhkbjyzltzpvocafu 2 16 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 2 17 , , , work_zhhbvy463fhkbjyzltzpvocafu 2 18 T T NNP work_zhhbvy463fhkbjyzltzpvocafu 2 19 GDNF GDNF NNP work_zhhbvy463fhkbjyzltzpvocafu 2 20 , , , work_zhhbvy463fhkbjyzltzpvocafu 2 21 NTN NTN NNP work_zhhbvy463fhkbjyzltzpvocafu 2 22 , , , work_zhhbvy463fhkbjyzltzpvocafu 2 23 SIP1 SIP1 NNP work_zhhbvy463fhkbjyzltzpvocafu 2 24 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 2 25 have have VBP work_zhhbvy463fhkbjyzltzpvocafu 2 26 been be VBN work_zhhbvy463fhkbjyzltzpvocafu 2 27 identified identify VBN work_zhhbvy463fhkbjyzltzpvocafu 2 28 in in IN work_zhhbvy463fhkbjyzltzpvocafu 2 29 affected affect VBN work_zhhbvy463fhkbjyzltzpvocafu 2 30 individuals individual NNS work_zhhbvy463fhkbjyzltzpvocafu 2 31 , , , work_zhhbvy463fhkbjyzltzpvocafu 2 32 it -PRON- PRP work_zhhbvy463fhkbjyzltzpvocafu 2 33 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 2 34 now now RB work_zhhbvy463fhkbjyzltzpvocafu 2 35 clear clear JJ work_zhhbvy463fhkbjyzltzpvocafu 2 36 that that IN work_zhhbvy463fhkbjyzltzpvocafu 2 37 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 2 38 and and CC work_zhhbvy463fhkbjyzltzpvocafu 2 39 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 2 40 are be VBP work_zhhbvy463fhkbjyzltzpvocafu 2 41 the the DT work_zhhbvy463fhkbjyzltzpvocafu 2 42 primary primary JJ work_zhhbvy463fhkbjyzltzpvocafu 2 43 genes gene NNS work_zhhbvy463fhkbjyzltzpvocafu 2 44 implicated implicate VBN work_zhhbvy463fhkbjyzltzpvocafu 2 45 in in IN work_zhhbvy463fhkbjyzltzpvocafu 2 46 the the DT work_zhhbvy463fhkbjyzltzpvocafu 2 47 etiology etiology NN work_zhhbvy463fhkbjyzltzpvocafu 2 48 of of IN work_zhhbvy463fhkbjyzltzpvocafu 2 49 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 2 50 . . . work_zhhbvy463fhkbjyzltzpvocafu 3 1 All all DT work_zhhbvy463fhkbjyzltzpvocafu 3 2 eight eight CD work_zhhbvy463fhkbjyzltzpvocafu 3 3 genes gene NNS work_zhhbvy463fhkbjyzltzpvocafu 3 4 are be VBP work_zhhbvy463fhkbjyzltzpvocafu 3 5 involved involve VBN work_zhhbvy463fhkbjyzltzpvocafu 3 6 in in IN work_zhhbvy463fhkbjyzltzpvocafu 3 7 the the DT work_zhhbvy463fhkbjyzltzpvocafu 3 8 early early JJ work_zhhbvy463fhkbjyzltzpvocafu 3 9 development development NN work_zhhbvy463fhkbjyzltzpvocafu 3 10 of of IN work_zhhbvy463fhkbjyzltzpvocafu 3 11 the the DT work_zhhbvy463fhkbjyzltzpvocafu 3 12 enteric enteric JJ work_zhhbvy463fhkbjyzltzpvocafu 3 13 nervous nervous JJ work_zhhbvy463fhkbjyzltzpvocafu 3 14 system system NN work_zhhbvy463fhkbjyzltzpvocafu 3 15 , , , work_zhhbvy463fhkbjyzltzpvocafu 3 16 and and CC work_zhhbvy463fhkbjyzltzpvocafu 3 17 most most JJS work_zhhbvy463fhkbjyzltzpvocafu 3 18 act act VBP work_zhhbvy463fhkbjyzltzpvocafu 3 19 through through IN work_zhhbvy463fhkbjyzltzpvocafu 3 20 two two CD work_zhhbvy463fhkbjyzltzpvocafu 3 21 distinct distinct JJ work_zhhbvy463fhkbjyzltzpvocafu 3 22 biochemical biochemical JJ work_zhhbvy463fhkbjyzltzpvocafu 3 23 pathways pathway NNS work_zhhbvy463fhkbjyzltzpvocafu 3 24 mediated mediate VBN work_zhhbvy463fhkbjyzltzpvocafu 3 25 by by IN work_zhhbvy463fhkbjyzltzpvocafu 3 26 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 3 27 aT aT NNP work_zhhbvy463fhkbjyzltzpvocafu 3 28 nd nd NNP work_zhhbvy463fhkbjyzltzpvocafu 3 29 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 3 30 . . . work_zhhbvy463fhkbjyzltzpvocafu 4 1 Mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 4 2 in in IN work_zhhbvy463fhkbjyzltzpvocafu 4 3 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 4 4 aT aT NNP work_zhhbvy463fhkbjyzltzpvocafu 4 5 nd nd NNP work_zhhbvy463fhkbjyzltzpvocafu 4 6 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 4 7 account account VBP work_zhhbvy463fhkbjyzltzpvocafu 4 8 for for IN work_zhhbvy463fhkbjyzltzpvocafu 4 9 up up IN work_zhhbvy463fhkbjyzltzpvocafu 4 10 to to TO work_zhhbvy463fhkbjyzltzpvocafu 4 11 50 50 CD work_zhhbvy463fhkbjyzltzpvocafu 4 12 % % NN work_zhhbvy463fhkbjyzltzpvocafu 4 13 and and CC work_zhhbvy463fhkbjyzltzpvocafu 4 14 5 5 CD work_zhhbvy463fhkbjyzltzpvocafu 4 15 % % NN work_zhhbvy463fhkbjyzltzpvocafu 4 16 of of IN work_zhhbvy463fhkbjyzltzpvocafu 4 17 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 4 18 cases case NNS work_zhhbvy463fhkbjyzltzpvocafu 4 19 in in IN work_zhhbvy463fhkbjyzltzpvocafu 4 20 the the DT work_zhhbvy463fhkbjyzltzpvocafu 4 21 general general JJ work_zhhbvy463fhkbjyzltzpvocafu 4 22 population population NN work_zhhbvy463fhkbjyzltzpvocafu 4 23 , , , work_zhhbvy463fhkbjyzltzpvocafu 4 24 respectively respectively RB work_zhhbvy463fhkbjyzltzpvocafu 4 25 . . . work_zhhbvy463fhkbjyzltzpvocafu 5 1 Interaction interaction NN work_zhhbvy463fhkbjyzltzpvocafu 5 2 between between IN work_zhhbvy463fhkbjyzltzpvocafu 5 3 these these DT work_zhhbvy463fhkbjyzltzpvocafu 5 4 two two CD work_zhhbvy463fhkbjyzltzpvocafu 5 5 signaling signal VBG work_zhhbvy463fhkbjyzltzpvocafu 5 6 pathways pathway NNS work_zhhbvy463fhkbjyzltzpvocafu 5 7 could could MD work_zhhbvy463fhkbjyzltzpvocafu 5 8 modify modify VB work_zhhbvy463fhkbjyzltzpvocafu 5 9 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 5 10 expression expression NN work_zhhbvy463fhkbjyzltzpvocafu 5 11 and and CC work_zhhbvy463fhkbjyzltzpvocafu 5 12 , , , work_zhhbvy463fhkbjyzltzpvocafu 5 13 therefore therefore RB work_zhhbvy463fhkbjyzltzpvocafu 5 14 , , , work_zhhbvy463fhkbjyzltzpvocafu 5 15 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 5 16 phenotype phenotype NNP work_zhhbvy463fhkbjyzltzpvocafu 5 17 . . . work_zhhbvy463fhkbjyzltzpvocafu 6 1 Here here RB work_zhhbvy463fhkbjyzltzpvocafu 6 2 , , , work_zhhbvy463fhkbjyzltzpvocafu 6 3 we -PRON- PRP work_zhhbvy463fhkbjyzltzpvocafu 6 4 report report VBP work_zhhbvy463fhkbjyzltzpvocafu 6 5 the the DT work_zhhbvy463fhkbjyzltzpvocafu 6 6 case case NN work_zhhbvy463fhkbjyzltzpvocafu 6 7 of of IN work_zhhbvy463fhkbjyzltzpvocafu 6 8 a a DT work_zhhbvy463fhkbjyzltzpvocafu 6 9 1-year 1-year CD work_zhhbvy463fhkbjyzltzpvocafu 6 10 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 6 11 old old JJ work_zhhbvy463fhkbjyzltzpvocafu 6 12 Taiwanese taiwanese JJ work_zhhbvy463fhkbjyzltzpvocafu 6 13 boy boy NN work_zhhbvy463fhkbjyzltzpvocafu 6 14 who who WP work_zhhbvy463fhkbjyzltzpvocafu 6 15 presented present VBD work_zhhbvy463fhkbjyzltzpvocafu 6 16 with with IN work_zhhbvy463fhkbjyzltzpvocafu 6 17 abdominal abdominal JJ work_zhhbvy463fhkbjyzltzpvocafu 6 18 distension distension NN work_zhhbvy463fhkbjyzltzpvocafu 6 19 since since IN work_zhhbvy463fhkbjyzltzpvocafu 6 20 birth birth NN work_zhhbvy463fhkbjyzltzpvocafu 6 21 and and CC work_zhhbvy463fhkbjyzltzpvocafu 6 22 bilious bilious JJ work_zhhbvy463fhkbjyzltzpvocafu 6 23 vomiting vomiting NN work_zhhbvy463fhkbjyzltzpvocafu 6 24 after after IN work_zhhbvy463fhkbjyzltzpvocafu 6 25 feeding feed VBG work_zhhbvy463fhkbjyzltzpvocafu 6 26 . . . work_zhhbvy463fhkbjyzltzpvocafu 7 1 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 7 2 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 7 3 short short JJ work_zhhbvy463fhkbjyzltzpvocafu 7 4 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 7 5 segment segment NN work_zhhbvy463fhkbjyzltzpvocafu 7 6 type type NN work_zhhbvy463fhkbjyzltzpvocafu 7 7 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 7 8 was be VBD work_zhhbvy463fhkbjyzltzpvocafu 7 9 diagnosed diagnose VBN work_zhhbvy463fhkbjyzltzpvocafu 7 10 based base VBN work_zhhbvy463fhkbjyzltzpvocafu 7 11 on on IN work_zhhbvy463fhkbjyzltzpvocafu 7 12 X X NNP work_zhhbvy463fhkbjyzltzpvocafu 7 13 - - NN work_zhhbvy463fhkbjyzltzpvocafu 7 14 ray ray NNP work_zhhbvy463fhkbjyzltzpvocafu 7 15 , , , work_zhhbvy463fhkbjyzltzpvocafu 7 16 lower low JJR work_zhhbvy463fhkbjyzltzpvocafu 7 17 gastrointestinal gastrointestinal JJ work_zhhbvy463fhkbjyzltzpvocafu 7 18 series series NN work_zhhbvy463fhkbjyzltzpvocafu 7 19 and and CC work_zhhbvy463fhkbjyzltzpvocafu 7 20 biopsy biopsy NN work_zhhbvy463fhkbjyzltzpvocafu 7 21 findings finding NNS work_zhhbvy463fhkbjyzltzpvocafu 7 22 . . . work_zhhbvy463fhkbjyzltzpvocafu 8 1 Mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 8 2 analysis analysis NN work_zhhbvy463fhkbjyzltzpvocafu 8 3 revealed reveal VBD work_zhhbvy463fhkbjyzltzpvocafu 8 4 a a DT work_zhhbvy463fhkbjyzltzpvocafu 8 5 heterozygous heterozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 8 6 T t NN work_zhhbvy463fhkbjyzltzpvocafu 8 7 > > NN work_zhhbvy463fhkbjyzltzpvocafu 8 8 C c NN work_zhhbvy463fhkbjyzltzpvocafu 8 9 missense missense NN work_zhhbvy463fhkbjyzltzpvocafu 8 10 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 8 11 in in IN work_zhhbvy463fhkbjyzltzpvocafu 8 12 exon exon NNP work_zhhbvy463fhkbjyzltzpvocafu 8 13 1 1 CD work_zhhbvy463fhkbjyzltzpvocafu 8 14 of of IN work_zhhbvy463fhkbjyzltzpvocafu 8 15 the the DT work_zhhbvy463fhkbjyzltzpvocafu 8 16 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 8 17 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 8 18 , , , work_zhhbvy463fhkbjyzltzpvocafu 8 19 that that WDT work_zhhbvy463fhkbjyzltzpvocafu 8 20 substitutes substitute VBZ work_zhhbvy463fhkbjyzltzpvocafu 8 21 the the DT work_zhhbvy463fhkbjyzltzpvocafu 8 22 highly highly RB work_zhhbvy463fhkbjyzltzpvocafu 8 23 conserved conserve VBN work_zhhbvy463fhkbjyzltzpvocafu 8 24 cysteine-90 cysteine-90 NN work_zhhbvy463fhkbjyzltzpvocafu 8 25 residue residue NN work_zhhbvy463fhkbjyzltzpvocafu 8 26 in in IN work_zhhbvy463fhkbjyzltzpvocafu 8 27 the the DT work_zhhbvy463fhkbjyzltzpvocafu 8 28 extracellular extracellular JJ work_zhhbvy463fhkbjyzltzpvocafu 8 29 domain domain NN work_zhhbvy463fhkbjyzltzpvocafu 8 30 of of IN work_zhhbvy463fhkbjyzltzpvocafu 8 31 the the DT work_zhhbvy463fhkbjyzltzpvocafu 8 32 G G NNP work_zhhbvy463fhkbjyzltzpvocafu 8 33 protein protein NN work_zhhbvy463fhkbjyzltzpvocafu 8 34 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 8 35 coupled couple VBN work_zhhbvy463fhkbjyzltzpvocafu 8 36 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 8 37 with with IN work_zhhbvy463fhkbjyzltzpvocafu 8 38 an an DT work_zhhbvy463fhkbjyzltzpvocafu 8 39 arginine arginine NN work_zhhbvy463fhkbjyzltzpvocafu 8 40 residue residue NN work_zhhbvy463fhkbjyzltzpvocafu 8 41 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 8 42 C90R C90R NNP work_zhhbvy463fhkbjyzltzpvocafu 8 43 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 8 44 . . . work_zhhbvy463fhkbjyzltzpvocafu 9 1 No no DT work_zhhbvy463fhkbjyzltzpvocafu 9 2 RET ret NN work_zhhbvy463fhkbjyzltzpvocafu 9 3 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 9 4 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 9 5 was be VBD work_zhhbvy463fhkbjyzltzpvocafu 9 6 detected detect VBN work_zhhbvy463fhkbjyzltzpvocafu 9 7 in in IN work_zhhbvy463fhkbjyzltzpvocafu 9 8 this this DT work_zhhbvy463fhkbjyzltzpvocafu 9 9 patient patient NN work_zhhbvy463fhkbjyzltzpvocafu 9 10 . . . work_zhhbvy463fhkbjyzltzpvocafu 10 1 [ [ -LRB- work_zhhbvy463fhkbjyzltzpvocafu 10 2 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 10 3 Formos Formos NNP work_zhhbvy463fhkbjyzltzpvocafu 10 4 Med Med NNP work_zhhbvy463fhkbjyzltzpvocafu 10 5 Assoc Assoc NNP work_zhhbvy463fhkbjyzltzpvocafu 10 6 2006;105(4 2006;105(4 CD work_zhhbvy463fhkbjyzltzpvocafu 10 7 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 10 8 : : : work_zhhbvy463fhkbjyzltzpvocafu 10 9 349–354 349–354 CD work_zhhbvy463fhkbjyzltzpvocafu 10 10 ] ] -RRB- work_zhhbvy463fhkbjyzltzpvocafu 10 11 Key Key NNP work_zhhbvy463fhkbjyzltzpvocafu 10 12 Words word NNS work_zhhbvy463fhkbjyzltzpvocafu 10 13 : : : work_zhhbvy463fhkbjyzltzpvocafu 10 14 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 10 15 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 10 16 , , , work_zhhbvy463fhkbjyzltzpvocafu 10 17 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 10 18 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 10 19 , , , work_zhhbvy463fhkbjyzltzpvocafu 10 20 Taiwanese taiwanese JJ work_zhhbvy463fhkbjyzltzpvocafu 10 21 Departments Departments NNPS work_zhhbvy463fhkbjyzltzpvocafu 10 22 of of IN work_zhhbvy463fhkbjyzltzpvocafu 10 23 Emergency Emergency NNP work_zhhbvy463fhkbjyzltzpvocafu 10 24 Medicine Medicine NNP work_zhhbvy463fhkbjyzltzpvocafu 10 25 and and CC work_zhhbvy463fhkbjyzltzpvocafu 10 26 1Surgery 1Surgery NNP work_zhhbvy463fhkbjyzltzpvocafu 10 27 , , , work_zhhbvy463fhkbjyzltzpvocafu 10 28 National National NNP work_zhhbvy463fhkbjyzltzpvocafu 10 29 Cheng Cheng NNP work_zhhbvy463fhkbjyzltzpvocafu 10 30 Kung Kung NNP work_zhhbvy463fhkbjyzltzpvocafu 10 31 University University NNP work_zhhbvy463fhkbjyzltzpvocafu 10 32 Medical Medical NNP work_zhhbvy463fhkbjyzltzpvocafu 10 33 College College NNP work_zhhbvy463fhkbjyzltzpvocafu 10 34 and and CC work_zhhbvy463fhkbjyzltzpvocafu 10 35 Hospital Hospital NNP work_zhhbvy463fhkbjyzltzpvocafu 10 36 , , , work_zhhbvy463fhkbjyzltzpvocafu 10 37 Tainan Tainan NNP work_zhhbvy463fhkbjyzltzpvocafu 10 38 , , , work_zhhbvy463fhkbjyzltzpvocafu 10 39 Taiwan Taiwan NNP work_zhhbvy463fhkbjyzltzpvocafu 10 40 . . . work_zhhbvy463fhkbjyzltzpvocafu 11 1 Received receive VBN work_zhhbvy463fhkbjyzltzpvocafu 11 2 : : : work_zhhbvy463fhkbjyzltzpvocafu 11 3 March March NNP work_zhhbvy463fhkbjyzltzpvocafu 11 4 31 31 CD work_zhhbvy463fhkbjyzltzpvocafu 11 5 , , , work_zhhbvy463fhkbjyzltzpvocafu 11 6 2005 2005 CD work_zhhbvy463fhkbjyzltzpvocafu 11 7 Revised revise VBN work_zhhbvy463fhkbjyzltzpvocafu 11 8 : : : work_zhhbvy463fhkbjyzltzpvocafu 11 9 May May NNP work_zhhbvy463fhkbjyzltzpvocafu 11 10 3 3 CD work_zhhbvy463fhkbjyzltzpvocafu 11 11 , , , work_zhhbvy463fhkbjyzltzpvocafu 11 12 2005 2005 CD work_zhhbvy463fhkbjyzltzpvocafu 11 13 Accepted accept VBN work_zhhbvy463fhkbjyzltzpvocafu 11 14 : : : work_zhhbvy463fhkbjyzltzpvocafu 11 15 July July NNP work_zhhbvy463fhkbjyzltzpvocafu 11 16 5 5 CD work_zhhbvy463fhkbjyzltzpvocafu 11 17 , , , work_zhhbvy463fhkbjyzltzpvocafu 11 18 2005 2005 CD work_zhhbvy463fhkbjyzltzpvocafu 11 19 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 11 20 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 11 21 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 11 22 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 11 23 , , , work_zhhbvy463fhkbjyzltzpvocafu 11 24 OMIM OMIM NNP work_zhhbvy463fhkbjyzltzpvocafu 11 25 142623 142623 CD work_zhhbvy463fhkbjyzltzpvocafu 11 26 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 11 27 , , , work_zhhbvy463fhkbjyzltzpvocafu 11 28 or or CC work_zhhbvy463fhkbjyzltzpvocafu 11 29 aganglionic aganglionic JJ work_zhhbvy463fhkbjyzltzpvocafu 11 30 megacolon megacolon NN work_zhhbvy463fhkbjyzltzpvocafu 11 31 , , , work_zhhbvy463fhkbjyzltzpvocafu 11 32 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 11 33 a a DT work_zhhbvy463fhkbjyzltzpvocafu 11 34 congenital congenital JJ work_zhhbvy463fhkbjyzltzpvocafu 11 35 disor- disor- NN work_zhhbvy463fhkbjyzltzpvocafu 11 36 der der NN work_zhhbvy463fhkbjyzltzpvocafu 11 37 characterized characterize VBN work_zhhbvy463fhkbjyzltzpvocafu 11 38 by by IN work_zhhbvy463fhkbjyzltzpvocafu 11 39 the the DT work_zhhbvy463fhkbjyzltzpvocafu 11 40 absence absence NN work_zhhbvy463fhkbjyzltzpvocafu 11 41 of of IN work_zhhbvy463fhkbjyzltzpvocafu 11 42 enteric enteric JJ work_zhhbvy463fhkbjyzltzpvocafu 11 43 gan- gan- NN work_zhhbvy463fhkbjyzltzpvocafu 11 44 glia glia NN work_zhhbvy463fhkbjyzltzpvocafu 11 45 along along IN work_zhhbvy463fhkbjyzltzpvocafu 11 46 a a DT work_zhhbvy463fhkbjyzltzpvocafu 11 47 variable variable JJ work_zhhbvy463fhkbjyzltzpvocafu 11 48 length length NN work_zhhbvy463fhkbjyzltzpvocafu 11 49 of of IN work_zhhbvy463fhkbjyzltzpvocafu 11 50 the the DT work_zhhbvy463fhkbjyzltzpvocafu 11 51 intestine intestine NN work_zhhbvy463fhkbjyzltzpvocafu 11 52 . . . work_zhhbvy463fhkbjyzltzpvocafu 12 1 The the DT work_zhhbvy463fhkbjyzltzpvocafu 12 2 estimated estimate VBN work_zhhbvy463fhkbjyzltzpvocafu 12 3 incidence incidence NN work_zhhbvy463fhkbjyzltzpvocafu 12 4 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 12 5 approximately approximately RB work_zhhbvy463fhkbjyzltzpvocafu 12 6 1 1 CD work_zhhbvy463fhkbjyzltzpvocafu 12 7 in in IN work_zhhbvy463fhkbjyzltzpvocafu 12 8 5000 5000 CD work_zhhbvy463fhkbjyzltzpvocafu 12 9 live live JJ work_zhhbvy463fhkbjyzltzpvocafu 12 10 births birth NNS work_zhhbvy463fhkbjyzltzpvocafu 12 11 . . . work_zhhbvy463fhkbjyzltzpvocafu 13 1 Molecular molecular JJ work_zhhbvy463fhkbjyzltzpvocafu 13 2 genetic genetic JJ work_zhhbvy463fhkbjyzltzpvocafu 13 3 analysis analysis NN work_zhhbvy463fhkbjyzltzpvocafu 13 4 has have VBZ work_zhhbvy463fhkbjyzltzpvocafu 13 5 identi- identi- VBN work_zhhbvy463fhkbjyzltzpvocafu 13 6 fied fie VBN work_zhhbvy463fhkbjyzltzpvocafu 13 7 several several JJ work_zhhbvy463fhkbjyzltzpvocafu 13 8 genes gene NNS work_zhhbvy463fhkbjyzltzpvocafu 13 9 that that WDT work_zhhbvy463fhkbjyzltzpvocafu 13 10 have have VBP work_zhhbvy463fhkbjyzltzpvocafu 13 11 a a DT work_zhhbvy463fhkbjyzltzpvocafu 13 12 role role NN work_zhhbvy463fhkbjyzltzpvocafu 13 13 in in IN work_zhhbvy463fhkbjyzltzpvocafu 13 14 the the DT work_zhhbvy463fhkbjyzltzpvocafu 13 15 develop- develop- JJ work_zhhbvy463fhkbjyzltzpvocafu 13 16 ment ment NN work_zhhbvy463fhkbjyzltzpvocafu 13 17 of of IN work_zhhbvy463fhkbjyzltzpvocafu 13 18 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 13 19 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 13 20 the the DT work_zhhbvy463fhkbjyzltzpvocafu 13 21 major major JJ work_zhhbvy463fhkbjyzltzpvocafu 13 22 susceptibility susceptibility NN work_zhhbvy463fhkbjyzltzpvocafu 13 23 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 13 24 for for IN work_zhhbvy463fhkbjyzltzpvocafu 13 25 this this DT work_zhhbvy463fhkbjyzltzpvocafu 13 26 disorder disorder NN work_zhhbvy463fhkbjyzltzpvocafu 13 27 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 13 28 the the DT work_zhhbvy463fhkbjyzltzpvocafu 13 29 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 13 30 proto proto RB work_zhhbvy463fhkbjyzltzpvocafu 13 31 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 13 32 oncogene.1 oncogene.1 CD work_zhhbvy463fhkbjyzltzpvocafu 13 33 Genes Genes NNP work_zhhbvy463fhkbjyzltzpvocafu 13 34 encoding encode VBG work_zhhbvy463fhkbjyzltzpvocafu 13 35 functional functional JJ work_zhhbvy463fhkbjyzltzpvocafu 13 36 ligands ligand NNS work_zhhbvy463fhkbjyzltzpvocafu 13 37 of of IN work_zhhbvy463fhkbjyzltzpvocafu 13 38 the the DT work_zhhbvy463fhkbjyzltzpvocafu 13 39 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 13 40 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 13 41 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 13 42 complex complex NN work_zhhbvy463fhkbjyzltzpvocafu 13 43 , , , work_zhhbvy463fhkbjyzltzpvocafu 13 44 such such JJ work_zhhbvy463fhkbjyzltzpvocafu 13 45 as as IN work_zhhbvy463fhkbjyzltzpvocafu 13 46 the the DT work_zhhbvy463fhkbjyzltzpvocafu 13 47 glial glial JJ work_zhhbvy463fhkbjyzltzpvocafu 13 48 cell cell NN work_zhhbvy463fhkbjyzltzpvocafu 13 49 line line NN work_zhhbvy463fhkbjyzltzpvocafu 13 50 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 13 51 derived derive VBN work_zhhbvy463fhkbjyzltzpvocafu 13 52 neu- neu- JJ work_zhhbvy463fhkbjyzltzpvocafu 13 53 rotropic rotropic JJ work_zhhbvy463fhkbjyzltzpvocafu 13 54 factor factor NN work_zhhbvy463fhkbjyzltzpvocafu 13 55 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 13 56 GDNF GDNF NNP work_zhhbvy463fhkbjyzltzpvocafu 13 57 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 13 58 , , , work_zhhbvy463fhkbjyzltzpvocafu 13 59 neurturin neurturin NNP work_zhhbvy463fhkbjyzltzpvocafu 13 60 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 13 61 NTN),2 NTN),2 NNP work_zhhbvy463fhkbjyzltzpvocafu 13 62 arte- arte- NNP work_zhhbvy463fhkbjyzltzpvocafu 13 63 min min NNP work_zhhbvy463fhkbjyzltzpvocafu 13 64 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 13 65 ARTN ARTN NNP work_zhhbvy463fhkbjyzltzpvocafu 13 66 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 13 67 , , , work_zhhbvy463fhkbjyzltzpvocafu 13 68 persephin persephin NNP work_zhhbvy463fhkbjyzltzpvocafu 13 69 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 13 70 PSPN PSPN NNP work_zhhbvy463fhkbjyzltzpvocafu 13 71 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 13 72 , , , work_zhhbvy463fhkbjyzltzpvocafu 13 73 and and CC work_zhhbvy463fhkbjyzltzpvocafu 13 74 correspond- correspond- NNP work_zhhbvy463fhkbjyzltzpvocafu 13 75 ing ing NN work_zhhbvy463fhkbjyzltzpvocafu 13 76 members member NNS work_zhhbvy463fhkbjyzltzpvocafu 13 77 of of IN work_zhhbvy463fhkbjyzltzpvocafu 13 78 the the DT work_zhhbvy463fhkbjyzltzpvocafu 13 79 GDNF GDNF NNP work_zhhbvy463fhkbjyzltzpvocafu 13 80 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 13 81 family family NN work_zhhbvy463fhkbjyzltzpvocafu 13 82 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 13 83 genes gene NNS work_zhhbvy463fhkbjyzltzpvocafu 13 84 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 13 85 GFR GFR NNP work_zhhbvy463fhkbjyzltzpvocafu 13 86 -1 -1 NNP work_zhhbvy463fhkbjyzltzpvocafu 13 87 - - : work_zhhbvy463fhkbjyzltzpvocafu 13 88 4),2 4),2 CD work_zhhbvy463fhkbjyzltzpvocafu 13 89 have have VBP work_zhhbvy463fhkbjyzltzpvocafu 13 90 also also RB work_zhhbvy463fhkbjyzltzpvocafu 13 91 been be VBN work_zhhbvy463fhkbjyzltzpvocafu 13 92 suggested suggest VBN work_zhhbvy463fhkbjyzltzpvocafu 13 93 as as IN work_zhhbvy463fhkbjyzltzpvocafu 13 94 putative putative JJ work_zhhbvy463fhkbjyzltzpvocafu 13 95 susceptibility susceptibility NN work_zhhbvy463fhkbjyzltzpvocafu 13 96 genes gene NNS work_zhhbvy463fhkbjyzltzpvocafu 13 97 associated associate VBN work_zhhbvy463fhkbjyzltzpvocafu 13 98 with with IN work_zhhbvy463fhkbjyzltzpvocafu 13 99 * * NFP work_zhhbvy463fhkbjyzltzpvocafu 13 100 Correspondence correspondence NN work_zhhbvy463fhkbjyzltzpvocafu 13 101 to to IN work_zhhbvy463fhkbjyzltzpvocafu 13 102 : : : work_zhhbvy463fhkbjyzltzpvocafu 13 103 Dr. Dr. NNP work_zhhbvy463fhkbjyzltzpvocafu 13 104 Ming Ming NNP work_zhhbvy463fhkbjyzltzpvocafu 13 105 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 13 106 Che Che NNP work_zhhbvy463fhkbjyzltzpvocafu 13 107 Tsai Tsai NNP work_zhhbvy463fhkbjyzltzpvocafu 13 108 , , , work_zhhbvy463fhkbjyzltzpvocafu 13 109 Department Department NNP work_zhhbvy463fhkbjyzltzpvocafu 13 110 of of IN work_zhhbvy463fhkbjyzltzpvocafu 13 111 Emergency Emergency NNP work_zhhbvy463fhkbjyzltzpvocafu 13 112 Medicine Medicine NNP work_zhhbvy463fhkbjyzltzpvocafu 13 113 , , , work_zhhbvy463fhkbjyzltzpvocafu 13 114 National National NNP work_zhhbvy463fhkbjyzltzpvocafu 13 115 Cheng Cheng NNP work_zhhbvy463fhkbjyzltzpvocafu 13 116 Kung Kung NNP work_zhhbvy463fhkbjyzltzpvocafu 13 117 University University NNP work_zhhbvy463fhkbjyzltzpvocafu 13 118 Hospital Hospital NNP work_zhhbvy463fhkbjyzltzpvocafu 13 119 , , , work_zhhbvy463fhkbjyzltzpvocafu 13 120 138 138 CD work_zhhbvy463fhkbjyzltzpvocafu 13 121 , , , work_zhhbvy463fhkbjyzltzpvocafu 13 122 Sheng Sheng NNP work_zhhbvy463fhkbjyzltzpvocafu 13 123 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 13 124 Li Li NNP work_zhhbvy463fhkbjyzltzpvocafu 13 125 Road Road NNP work_zhhbvy463fhkbjyzltzpvocafu 13 126 , , , work_zhhbvy463fhkbjyzltzpvocafu 13 127 Tainan Tainan NNP work_zhhbvy463fhkbjyzltzpvocafu 13 128 704 704 CD work_zhhbvy463fhkbjyzltzpvocafu 13 129 , , , work_zhhbvy463fhkbjyzltzpvocafu 13 130 Taiwan Taiwan NNP work_zhhbvy463fhkbjyzltzpvocafu 13 131 . . . work_zhhbvy463fhkbjyzltzpvocafu 14 1 E e NN work_zhhbvy463fhkbjyzltzpvocafu 14 2 - - NN work_zhhbvy463fhkbjyzltzpvocafu 14 3 mail mail NN work_zhhbvy463fhkbjyzltzpvocafu 14 4 : : : work_zhhbvy463fhkbjyzltzpvocafu 14 5 terence39@yahoo.com terence39@yahoo.com ADD work_zhhbvy463fhkbjyzltzpvocafu 14 6 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 14 7 . . . work_zhhbvy463fhkbjyzltzpvocafu 15 1 Waardenburg Waardenburg NNP work_zhhbvy463fhkbjyzltzpvocafu 15 2 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 15 3 Shah Shah NNP work_zhhbvy463fhkbjyzltzpvocafu 15 4 syndrome syndrome NN work_zhhbvy463fhkbjyzltzpvocafu 15 5 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 15 6 a a DT work_zhhbvy463fhkbjyzltzpvocafu 15 7 dis- dis- JJ work_zhhbvy463fhkbjyzltzpvocafu 15 8 order order NN work_zhhbvy463fhkbjyzltzpvocafu 15 9 of of IN work_zhhbvy463fhkbjyzltzpvocafu 15 10 the the DT work_zhhbvy463fhkbjyzltzpvocafu 15 11 embryonic embryonic JJ work_zhhbvy463fhkbjyzltzpvocafu 15 12 neural neural JJ work_zhhbvy463fhkbjyzltzpvocafu 15 13 crest crest NN work_zhhbvy463fhkbjyzltzpvocafu 15 14 that that WDT work_zhhbvy463fhkbjyzltzpvocafu 15 15 combines combine VBZ work_zhhbvy463fhkbjyzltzpvocafu 15 16 the the DT work_zhhbvy463fhkbjyzltzpvocafu 15 17 clinical clinical JJ work_zhhbvy463fhkbjyzltzpvocafu 15 18 features feature NNS work_zhhbvy463fhkbjyzltzpvocafu 15 19 of of IN work_zhhbvy463fhkbjyzltzpvocafu 15 20 Waardenburg Waardenburg NNP work_zhhbvy463fhkbjyzltzpvocafu 15 21 syndrome syndrome NN work_zhhbvy463fhkbjyzltzpvocafu 15 22 and and CC work_zhhbvy463fhkbjyzltzpvocafu 15 23 HSCR.3 hscr.3 NN work_zhhbvy463fhkbjyzltzpvocafu 15 24 Patients Patients NNPS work_zhhbvy463fhkbjyzltzpvocafu 15 25 with with IN work_zhhbvy463fhkbjyzltzpvocafu 15 26 Waardenburg Waardenburg NNP work_zhhbvy463fhkbjyzltzpvocafu 15 27 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 15 28 Shah Shah NNP work_zhhbvy463fhkbjyzltzpvocafu 15 29 syndrome syndrome NN work_zhhbvy463fhkbjyzltzpvocafu 15 30 with with IN work_zhhbvy463fhkbjyzltzpvocafu 15 31 megacolon megacolon NN work_zhhbvy463fhkbjyzltzpvocafu 15 32 have have VBP work_zhhbvy463fhkbjyzltzpvocafu 15 33 a a DT work_zhhbvy463fhkbjyzltzpvocafu 15 34 homozygous homozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 15 35 founder founder NN work_zhhbvy463fhkbjyzltzpvocafu 15 36 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 15 37 in in IN work_zhhbvy463fhkbjyzltzpvocafu 15 38 the the DT work_zhhbvy463fhkbjyzltzpvocafu 15 39 G g NN work_zhhbvy463fhkbjyzltzpvocafu 15 40 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 15 41 protein protein NN work_zhhbvy463fhkbjyzltzpvocafu 15 42 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 15 43 coupled couple VBN work_zhhbvy463fhkbjyzltzpvocafu 15 44 en- en- NN work_zhhbvy463fhkbjyzltzpvocafu 15 45 dothelin dothelin NNP work_zhhbvy463fhkbjyzltzpvocafu 15 46 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 15 47 B B NNP work_zhhbvy463fhkbjyzltzpvocafu 15 48 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 15 49 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 15 50 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 15 51 EDNRB),4 ednrb),4 NN work_zhhbvy463fhkbjyzltzpvocafu 15 52 whereas whereas IN work_zhhbvy463fhkbjyzltzpvocafu 15 53 het- het- JJ work_zhhbvy463fhkbjyzltzpvocafu 15 54 erozygous erozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 15 55 mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 15 56 of of IN work_zhhbvy463fhkbjyzltzpvocafu 15 57 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 15 58 and and CC work_zhhbvy463fhkbjyzltzpvocafu 15 59 endothelin- endothelin- NN work_zhhbvy463fhkbjyzltzpvocafu 15 60 3 3 CD work_zhhbvy463fhkbjyzltzpvocafu 15 61 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 15 62 EDN3)5 edn3)5 CD work_zhhbvy463fhkbjyzltzpvocafu 15 63 have have VBP work_zhhbvy463fhkbjyzltzpvocafu 15 64 been be VBN work_zhhbvy463fhkbjyzltzpvocafu 15 65 identified identify VBN work_zhhbvy463fhkbjyzltzpvocafu 15 66 in in IN work_zhhbvy463fhkbjyzltzpvocafu 15 67 individuals individual NNS work_zhhbvy463fhkbjyzltzpvocafu 15 68 with with IN work_zhhbvy463fhkbjyzltzpvocafu 15 69 isolated isolated JJ work_zhhbvy463fhkbjyzltzpvocafu 15 70 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 15 71 . . . work_zhhbvy463fhkbjyzltzpvocafu 16 1 Heterozygous heterozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 16 2 mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 16 3 of of IN work_zhhbvy463fhkbjyzltzpvocafu 16 4 SOX10 SOX10 NNP work_zhhbvy463fhkbjyzltzpvocafu 16 5 have have VBP work_zhhbvy463fhkbjyzltzpvocafu 16 6 been be VBN work_zhhbvy463fhkbjyzltzpvocafu 16 7 described describe VBN work_zhhbvy463fhkbjyzltzpvocafu 16 8 in in IN work_zhhbvy463fhkbjyzltzpvocafu 16 9 patients patient NNS work_zhhbvy463fhkbjyzltzpvocafu 16 10 with with IN work_zhhbvy463fhkbjyzltzpvocafu 16 11 megacolon megacolon NN work_zhhbvy463fhkbjyzltzpvocafu 16 12 in in IN work_zhhbvy463fhkbjyzltzpvocafu 16 13 Waardenburg Waardenburg NNP work_zhhbvy463fhkbjyzltzpvocafu 16 14 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 16 15 Shah Shah NNP work_zhhbvy463fhkbjyzltzpvocafu 16 16 syndrome.6 syndrome.6 NNP work_zhhbvy463fhkbjyzltzpvocafu 16 17 Mutation Mutation NNP work_zhhbvy463fhkbjyzltzpvocafu 16 18 of of IN work_zhhbvy463fhkbjyzltzpvocafu 16 19 the the DT work_zhhbvy463fhkbjyzltzpvocafu 16 20 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 16 21 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 16 22 accounts account VBZ work_zhhbvy463fhkbjyzltzpvocafu 16 23 for for IN work_zhhbvy463fhkbjyzltzpvocafu 16 24 up up IN work_zhhbvy463fhkbjyzltzpvocafu 16 25 to to TO work_zhhbvy463fhkbjyzltzpvocafu 16 26 20 20 CD work_zhhbvy463fhkbjyzltzpvocafu 16 27 % % NN work_zhhbvy463fhkbjyzltzpvocafu 16 28 of of IN work_zhhbvy463fhkbjyzltzpvocafu 16 29 sporadic sporadic JJ work_zhhbvy463fhkbjyzltzpvocafu 16 30 and and CC work_zhhbvy463fhkbjyzltzpvocafu 16 31 50 50 CD work_zhhbvy463fhkbjyzltzpvocafu 16 32 % % NN work_zhhbvy463fhkbjyzltzpvocafu 16 33 of of IN work_zhhbvy463fhkbjyzltzpvocafu 16 34 familial familial JJ work_zhhbvy463fhkbjyzltzpvocafu 16 35 cases.7 cases.7 NN work_zhhbvy463fhkbjyzltzpvocafu 16 36 Mu- mu- JJ work_zhhbvy463fhkbjyzltzpvocafu 16 37 tation tation NN work_zhhbvy463fhkbjyzltzpvocafu 16 38 of of IN work_zhhbvy463fhkbjyzltzpvocafu 16 39 the the DT work_zhhbvy463fhkbjyzltzpvocafu 16 40 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 16 41 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 16 42 accounts account VBZ work_zhhbvy463fhkbjyzltzpvocafu 16 43 for for IN work_zhhbvy463fhkbjyzltzpvocafu 16 44 5–10 5–10 NNP work_zhhbvy463fhkbjyzltzpvocafu 16 45 % % NN work_zhhbvy463fhkbjyzltzpvocafu 16 46 of of IN work_zhhbvy463fhkbjyzltzpvocafu 16 47 all all DT work_zhhbvy463fhkbjyzltzpvocafu 16 48 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 16 49 cases.8,9 cases.8,9 . work_zhhbvy463fhkbjyzltzpvocafu 16 50 Short short JJ work_zhhbvy463fhkbjyzltzpvocafu 16 51 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 16 52 segment segment NN work_zhhbvy463fhkbjyzltzpvocafu 16 53 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 16 54 occurs occur VBZ work_zhhbvy463fhkbjyzltzpvocafu 16 55 CASE case NN work_zhhbvy463fhkbjyzltzpvocafu 16 56 REPORT REPORT NNP work_zhhbvy463fhkbjyzltzpvocafu 16 57 A a DT work_zhhbvy463fhkbjyzltzpvocafu 16 58 De De NNP work_zhhbvy463fhkbjyzltzpvocafu 16 59 Novo Novo NNP work_zhhbvy463fhkbjyzltzpvocafu 16 60 Novel Novel NNP work_zhhbvy463fhkbjyzltzpvocafu 16 61 Mutation Mutation NNP work_zhhbvy463fhkbjyzltzpvocafu 16 62 of of IN work_zhhbvy463fhkbjyzltzpvocafu 16 63 the the DT work_zhhbvy463fhkbjyzltzpvocafu 16 64 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 16 65 Gene Gene NNP work_zhhbvy463fhkbjyzltzpvocafu 16 66 in in IN work_zhhbvy463fhkbjyzltzpvocafu 16 67 a a DT work_zhhbvy463fhkbjyzltzpvocafu 16 68 Taiwanese taiwanese JJ work_zhhbvy463fhkbjyzltzpvocafu 16 69 Boy Boy NNP work_zhhbvy463fhkbjyzltzpvocafu 16 70 with with IN work_zhhbvy463fhkbjyzltzpvocafu 16 71 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 16 72 Disease Disease NNP work_zhhbvy463fhkbjyzltzpvocafu 16 73 Wen Wen NNP work_zhhbvy463fhkbjyzltzpvocafu 16 74 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 16 75 Chau Chau NNP work_zhhbvy463fhkbjyzltzpvocafu 16 76 Chen Chen NNP work_zhhbvy463fhkbjyzltzpvocafu 16 77 , , , work_zhhbvy463fhkbjyzltzpvocafu 16 78 Shen Shen NNP work_zhhbvy463fhkbjyzltzpvocafu 16 79 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 16 80 Shun Shun NNP work_zhhbvy463fhkbjyzltzpvocafu 16 81 Chang,1 Chang,1 NNP work_zhhbvy463fhkbjyzltzpvocafu 16 82 Edgar Edgar NNP work_zhhbvy463fhkbjyzltzpvocafu 16 83 D. D. NNP work_zhhbvy463fhkbjyzltzpvocafu 16 84 Sy,1 Sy,1 NNP work_zhhbvy463fhkbjyzltzpvocafu 16 85 Ming Ming NNP work_zhhbvy463fhkbjyzltzpvocafu 16 86 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 16 87 Che Che NNP work_zhhbvy463fhkbjyzltzpvocafu 16 88 Tsai Tsai NNP work_zhhbvy463fhkbjyzltzpvocafu 16 89 * * NFP work_zhhbvy463fhkbjyzltzpvocafu 16 90 © © NNP work_zhhbvy463fhkbjyzltzpvocafu 16 91 2006 2006 CD work_zhhbvy463fhkbjyzltzpvocafu 16 92 Elsevier Elsevier NNP work_zhhbvy463fhkbjyzltzpvocafu 16 93 & & CC work_zhhbvy463fhkbjyzltzpvocafu 16 94 Formosan Formosan NNP work_zhhbvy463fhkbjyzltzpvocafu 16 95 Medical Medical NNP work_zhhbvy463fhkbjyzltzpvocafu 16 96 Association Association NNP work_zhhbvy463fhkbjyzltzpvocafu 16 97 350 350 CD work_zhhbvy463fhkbjyzltzpvocafu 16 98 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 16 99 Formos Formos NNP work_zhhbvy463fhkbjyzltzpvocafu 16 100 Med Med NNP work_zhhbvy463fhkbjyzltzpvocafu 16 101 Assoc Assoc NNP work_zhhbvy463fhkbjyzltzpvocafu 16 102 | | CD work_zhhbvy463fhkbjyzltzpvocafu 16 103 2006 2006 CD work_zhhbvy463fhkbjyzltzpvocafu 16 104 • • NNP work_zhhbvy463fhkbjyzltzpvocafu 16 105 Vol Vol NNP work_zhhbvy463fhkbjyzltzpvocafu 16 106 105 105 CD work_zhhbvy463fhkbjyzltzpvocafu 16 107 • • NNP work_zhhbvy463fhkbjyzltzpvocafu 16 108 No no DT work_zhhbvy463fhkbjyzltzpvocafu 16 109 4 4 CD work_zhhbvy463fhkbjyzltzpvocafu 16 110 W.C. W.C. NNP work_zhhbvy463fhkbjyzltzpvocafu 16 111 Chen Chen NNP work_zhhbvy463fhkbjyzltzpvocafu 16 112 , , , work_zhhbvy463fhkbjyzltzpvocafu 16 113 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 16 114 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 16 115 Physical Physical NNP work_zhhbvy463fhkbjyzltzpvocafu 16 116 examination examination NN work_zhhbvy463fhkbjyzltzpvocafu 16 117 did do VBD work_zhhbvy463fhkbjyzltzpvocafu 16 118 not not RB work_zhhbvy463fhkbjyzltzpvocafu 16 119 show show VB work_zhhbvy463fhkbjyzltzpvocafu 16 120 any any DT work_zhhbvy463fhkbjyzltzpvocafu 16 121 pig- pig- NN work_zhhbvy463fhkbjyzltzpvocafu 16 122 mentary mentary JJ work_zhhbvy463fhkbjyzltzpvocafu 16 123 anomalies anomaly NNS work_zhhbvy463fhkbjyzltzpvocafu 16 124 or or CC work_zhhbvy463fhkbjyzltzpvocafu 16 125 deafness deafness NN work_zhhbvy463fhkbjyzltzpvocafu 16 126 . . . work_zhhbvy463fhkbjyzltzpvocafu 17 1 X x NN work_zhhbvy463fhkbjyzltzpvocafu 17 2 - - NN work_zhhbvy463fhkbjyzltzpvocafu 17 3 ray ray NN work_zhhbvy463fhkbjyzltzpvocafu 17 4 examina- examina- NN work_zhhbvy463fhkbjyzltzpvocafu 17 5 tion tion NN work_zhhbvy463fhkbjyzltzpvocafu 17 6 showed show VBD work_zhhbvy463fhkbjyzltzpvocafu 17 7 diffuse diffuse NN work_zhhbvy463fhkbjyzltzpvocafu 17 8 enlarged enlarge VBN work_zhhbvy463fhkbjyzltzpvocafu 17 9 bowel bowel NN work_zhhbvy463fhkbjyzltzpvocafu 17 10 gas gas NN work_zhhbvy463fhkbjyzltzpvocafu 17 11 with with IN work_zhhbvy463fhkbjyzltzpvocafu 17 12 absent absent JJ work_zhhbvy463fhkbjyzltzpvocafu 17 13 bowel bowel NN work_zhhbvy463fhkbjyzltzpvocafu 17 14 gas gas NN work_zhhbvy463fhkbjyzltzpvocafu 17 15 in in IN work_zhhbvy463fhkbjyzltzpvocafu 17 16 the the DT work_zhhbvy463fhkbjyzltzpvocafu 17 17 rectal rectal JJ work_zhhbvy463fhkbjyzltzpvocafu 17 18 area area NN work_zhhbvy463fhkbjyzltzpvocafu 17 19 . . . work_zhhbvy463fhkbjyzltzpvocafu 18 1 Lower low JJR work_zhhbvy463fhkbjyzltzpvocafu 18 2 gas- gas- NN work_zhhbvy463fhkbjyzltzpvocafu 18 3 trointestinal trointestinal NNP work_zhhbvy463fhkbjyzltzpvocafu 18 4 series series NN work_zhhbvy463fhkbjyzltzpvocafu 18 5 showed show VBD work_zhhbvy463fhkbjyzltzpvocafu 18 6 an an DT work_zhhbvy463fhkbjyzltzpvocafu 18 7 enlarged enlarge VBN work_zhhbvy463fhkbjyzltzpvocafu 18 8 cecum cecum NN work_zhhbvy463fhkbjyzltzpvocafu 18 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 18 10 ascending ascend VBG work_zhhbvy463fhkbjyzltzpvocafu 18 11 colon colon NN work_zhhbvy463fhkbjyzltzpvocafu 18 12 and and CC work_zhhbvy463fhkbjyzltzpvocafu 18 13 ileum ileum NN work_zhhbvy463fhkbjyzltzpvocafu 18 14 without without IN work_zhhbvy463fhkbjyzltzpvocafu 18 15 focal focal JJ work_zhhbvy463fhkbjyzltzpvocafu 18 16 obstruc- obstruc- NNP work_zhhbvy463fhkbjyzltzpvocafu 18 17 tion tion NN work_zhhbvy463fhkbjyzltzpvocafu 18 18 sign sign NN work_zhhbvy463fhkbjyzltzpvocafu 18 19 . . . work_zhhbvy463fhkbjyzltzpvocafu 19 1 Suction suction NN work_zhhbvy463fhkbjyzltzpvocafu 19 2 biopsy biopsy NN work_zhhbvy463fhkbjyzltzpvocafu 19 3 was be VBD work_zhhbvy463fhkbjyzltzpvocafu 19 4 performed perform VBN work_zhhbvy463fhkbjyzltzpvocafu 19 5 and and CC work_zhhbvy463fhkbjyzltzpvocafu 19 6 pathology pathology NN work_zhhbvy463fhkbjyzltzpvocafu 19 7 revealed reveal VBD work_zhhbvy463fhkbjyzltzpvocafu 19 8 no no DT work_zhhbvy463fhkbjyzltzpvocafu 19 9 ganglial ganglial JJ work_zhhbvy463fhkbjyzltzpvocafu 19 10 neurons neuron NNS work_zhhbvy463fhkbjyzltzpvocafu 19 11 in in IN work_zhhbvy463fhkbjyzltzpvocafu 19 12 the the DT work_zhhbvy463fhkbjyzltzpvocafu 19 13 rectum rectum NN work_zhhbvy463fhkbjyzltzpvocafu 19 14 and and CC work_zhhbvy463fhkbjyzltzpvocafu 19 15 sigmoid sigmoid JJ work_zhhbvy463fhkbjyzltzpvocafu 19 16 colon colon NN work_zhhbvy463fhkbjyzltzpvocafu 19 17 . . . work_zhhbvy463fhkbjyzltzpvocafu 20 1 Acetylcholine Acetylcholine NNP work_zhhbvy463fhkbjyzltzpvocafu 20 2 ester- ester- XX work_zhhbvy463fhkbjyzltzpvocafu 20 3 ase ase NNP work_zhhbvy463fhkbjyzltzpvocafu 20 4 stain stain NNP work_zhhbvy463fhkbjyzltzpvocafu 20 5 was be VBD work_zhhbvy463fhkbjyzltzpvocafu 20 6 positive positive JJ work_zhhbvy463fhkbjyzltzpvocafu 20 7 . . . work_zhhbvy463fhkbjyzltzpvocafu 21 1 Under under IN work_zhhbvy463fhkbjyzltzpvocafu 21 2 the the DT work_zhhbvy463fhkbjyzltzpvocafu 21 3 impression impression NN work_zhhbvy463fhkbjyzltzpvocafu 21 4 of of IN work_zhhbvy463fhkbjyzltzpvocafu 21 5 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 21 6 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 21 7 short short JJ work_zhhbvy463fhkbjyzltzpvocafu 21 8 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 21 9 segment segment NN work_zhhbvy463fhkbjyzltzpvocafu 21 10 type type NN work_zhhbvy463fhkbjyzltzpvocafu 21 11 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 21 12 , , , work_zhhbvy463fhkbjyzltzpvocafu 21 13 colostomy colostomy NNP work_zhhbvy463fhkbjyzltzpvocafu 21 14 was be VBD work_zhhbvy463fhkbjyzltzpvocafu 21 15 ar- ar- RB work_zhhbvy463fhkbjyzltzpvocafu 21 16 ranged range VBN work_zhhbvy463fhkbjyzltzpvocafu 21 17 . . . work_zhhbvy463fhkbjyzltzpvocafu 22 1 PCR PCR NNP work_zhhbvy463fhkbjyzltzpvocafu 22 2 and and CC work_zhhbvy463fhkbjyzltzpvocafu 22 3 automated automate VBD work_zhhbvy463fhkbjyzltzpvocafu 22 4 DNA DNA NNP work_zhhbvy463fhkbjyzltzpvocafu 22 5 sequencing sequence VBG work_zhhbvy463fhkbjyzltzpvocafu 22 6 Genomic Genomic NNP work_zhhbvy463fhkbjyzltzpvocafu 22 7 DNA DNA NNP work_zhhbvy463fhkbjyzltzpvocafu 22 8 was be VBD work_zhhbvy463fhkbjyzltzpvocafu 22 9 extracted extract VBN work_zhhbvy463fhkbjyzltzpvocafu 22 10 from from IN work_zhhbvy463fhkbjyzltzpvocafu 22 11 the the DT work_zhhbvy463fhkbjyzltzpvocafu 22 12 peripheral peripheral JJ work_zhhbvy463fhkbjyzltzpvocafu 22 13 blood blood NN work_zhhbvy463fhkbjyzltzpvocafu 22 14 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 22 15 QIAamp QIAamp NNP work_zhhbvy463fhkbjyzltzpvocafu 22 16 Midi Midi NNP work_zhhbvy463fhkbjyzltzpvocafu 22 17 Kit kit NN work_zhhbvy463fhkbjyzltzpvocafu 22 18 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 22 19 Qiagen Qiagen NNP work_zhhbvy463fhkbjyzltzpvocafu 22 20 , , , work_zhhbvy463fhkbjyzltzpvocafu 22 21 Valencia Valencia NNP work_zhhbvy463fhkbjyzltzpvocafu 22 22 , , , work_zhhbvy463fhkbjyzltzpvocafu 22 23 CA CA NNP work_zhhbvy463fhkbjyzltzpvocafu 22 24 , , , work_zhhbvy463fhkbjyzltzpvocafu 22 25 USA USA NNP work_zhhbvy463fhkbjyzltzpvocafu 22 26 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 22 27 of of IN work_zhhbvy463fhkbjyzltzpvocafu 22 28 the the DT work_zhhbvy463fhkbjyzltzpvocafu 22 29 proband proband NN work_zhhbvy463fhkbjyzltzpvocafu 22 30 and and CC work_zhhbvy463fhkbjyzltzpvocafu 22 31 parents parent NNS work_zhhbvy463fhkbjyzltzpvocafu 22 32 after after IN work_zhhbvy463fhkbjyzltzpvocafu 22 33 obtain- obtain- JJ work_zhhbvy463fhkbjyzltzpvocafu 22 34 ing e VBG work_zhhbvy463fhkbjyzltzpvocafu 22 35 informed inform VBN work_zhhbvy463fhkbjyzltzpvocafu 22 36 consent consent NN work_zhhbvy463fhkbjyzltzpvocafu 22 37 . . . work_zhhbvy463fhkbjyzltzpvocafu 23 1 DNA dna NN work_zhhbvy463fhkbjyzltzpvocafu 23 2 samples sample NNS work_zhhbvy463fhkbjyzltzpvocafu 23 3 were be VBD work_zhhbvy463fhkbjyzltzpvocafu 23 4 then then RB work_zhhbvy463fhkbjyzltzpvocafu 23 5 subjected subject VBN work_zhhbvy463fhkbjyzltzpvocafu 23 6 to to IN work_zhhbvy463fhkbjyzltzpvocafu 23 7 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 23 8 screening screening NN work_zhhbvy463fhkbjyzltzpvocafu 23 9 by by IN work_zhhbvy463fhkbjyzltzpvocafu 23 10 amplifica- amplifica- NNP work_zhhbvy463fhkbjyzltzpvocafu 23 11 tion tion NN work_zhhbvy463fhkbjyzltzpvocafu 23 12 of of IN work_zhhbvy463fhkbjyzltzpvocafu 23 13 segments segment NNS work_zhhbvy463fhkbjyzltzpvocafu 23 14 of of IN work_zhhbvy463fhkbjyzltzpvocafu 23 15 the the DT work_zhhbvy463fhkbjyzltzpvocafu 23 16 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 23 17 and and CC work_zhhbvy463fhkbjyzltzpvocafu 23 18 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 23 19 genes gene NNS work_zhhbvy463fhkbjyzltzpvocafu 23 20 with with IN work_zhhbvy463fhkbjyzltzpvocafu 23 21 primers primer NNS work_zhhbvy463fhkbjyzltzpvocafu 23 22 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 23 23 Tables tables NN work_zhhbvy463fhkbjyzltzpvocafu 23 24 1 1 CD work_zhhbvy463fhkbjyzltzpvocafu 23 25 and and CC work_zhhbvy463fhkbjyzltzpvocafu 23 26 2 2 CD work_zhhbvy463fhkbjyzltzpvocafu 23 27 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 23 28 synthesized synthesize VBN work_zhhbvy463fhkbjyzltzpvocafu 23 29 on on IN work_zhhbvy463fhkbjyzltzpvocafu 23 30 the the DT work_zhhbvy463fhkbjyzltzpvocafu 23 31 basis basis NN work_zhhbvy463fhkbjyzltzpvocafu 23 32 of of IN work_zhhbvy463fhkbjyzltzpvocafu 23 33 intronic intronic JJ work_zhhbvy463fhkbjyzltzpvocafu 23 34 sequences sequence NNS work_zhhbvy463fhkbjyzltzpvocafu 23 35 from from IN work_zhhbvy463fhkbjyzltzpvocafu 23 36 Genbank Genbank NNP work_zhhbvy463fhkbjyzltzpvocafu 23 37 . . . work_zhhbvy463fhkbjyzltzpvocafu 24 1 in in IN work_zhhbvy463fhkbjyzltzpvocafu 24 2 about about RB work_zhhbvy463fhkbjyzltzpvocafu 24 3 25 25 CD work_zhhbvy463fhkbjyzltzpvocafu 24 4 % % NN work_zhhbvy463fhkbjyzltzpvocafu 24 5 of of IN work_zhhbvy463fhkbjyzltzpvocafu 24 6 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 24 7 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 24 8 caused cause VBN work_zhhbvy463fhkbjyzltzpvocafu 24 9 cases case NNS work_zhhbvy463fhkbjyzltzpvocafu 24 10 and and CC work_zhhbvy463fhkbjyzltzpvocafu 24 11 in in IN work_zhhbvy463fhkbjyzltzpvocafu 24 12 more more JJR work_zhhbvy463fhkbjyzltzpvocafu 24 13 than than IN work_zhhbvy463fhkbjyzltzpvocafu 24 14 95 95 CD work_zhhbvy463fhkbjyzltzpvocafu 24 15 % % NN work_zhhbvy463fhkbjyzltzpvocafu 24 16 of of IN work_zhhbvy463fhkbjyzltzpvocafu 24 17 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 24 18 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 24 19 related relate VBN work_zhhbvy463fhkbjyzltzpvocafu 24 20 cases.8 cases.8 RB work_zhhbvy463fhkbjyzltzpvocafu 24 21 Even even RB work_zhhbvy463fhkbjyzltzpvocafu 24 22 in in IN work_zhhbvy463fhkbjyzltzpvocafu 24 23 fami- fami- NN work_zhhbvy463fhkbjyzltzpvocafu 24 24 lies lie VBZ work_zhhbvy463fhkbjyzltzpvocafu 24 25 with with IN work_zhhbvy463fhkbjyzltzpvocafu 24 26 apparent apparent JJ work_zhhbvy463fhkbjyzltzpvocafu 24 27 monogenic monogenic JJ work_zhhbvy463fhkbjyzltzpvocafu 24 28 inheritance inheritance NN work_zhhbvy463fhkbjyzltzpvocafu 24 29 , , , work_zhhbvy463fhkbjyzltzpvocafu 24 30 there there EX work_zhhbvy463fhkbjyzltzpvocafu 24 31 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 24 32 incomplete incomplete JJ work_zhhbvy463fhkbjyzltzpvocafu 24 33 penetrance penetrance NN work_zhhbvy463fhkbjyzltzpvocafu 24 34 of of IN work_zhhbvy463fhkbjyzltzpvocafu 24 35 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 24 36 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 24 37 causing cause VBG work_zhhbvy463fhkbjyzltzpvocafu 24 38 mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 24 39 and and CC work_zhhbvy463fhkbjyzltzpvocafu 24 40 intra- intra- JJ work_zhhbvy463fhkbjyzltzpvocafu 24 41 and and CC work_zhhbvy463fhkbjyzltzpvocafu 24 42 interfamily interfamily RB work_zhhbvy463fhkbjyzltzpvocafu 24 43 variation variation NN work_zhhbvy463fhkbjyzltzpvocafu 24 44 of of IN work_zhhbvy463fhkbjyzltzpvocafu 24 45 phenotype phenotype NN work_zhhbvy463fhkbjyzltzpvocafu 24 46 severity severity NN work_zhhbvy463fhkbjyzltzpvocafu 24 47 , , , work_zhhbvy463fhkbjyzltzpvocafu 24 48 suggesting suggest VBG work_zhhbvy463fhkbjyzltzpvocafu 24 49 that that IN work_zhhbvy463fhkbjyzltzpvocafu 24 50 modify- modify- NNP work_zhhbvy463fhkbjyzltzpvocafu 24 51 ing ing NNP work_zhhbvy463fhkbjyzltzpvocafu 24 52 genetic genetic JJ work_zhhbvy463fhkbjyzltzpvocafu 24 53 , , , work_zhhbvy463fhkbjyzltzpvocafu 24 54 stochastic stochastic JJ work_zhhbvy463fhkbjyzltzpvocafu 24 55 or or CC work_zhhbvy463fhkbjyzltzpvocafu 24 56 environmental environmental JJ work_zhhbvy463fhkbjyzltzpvocafu 24 57 factors factor NNS work_zhhbvy463fhkbjyzltzpvocafu 24 58 are be VBP work_zhhbvy463fhkbjyzltzpvocafu 24 59 involved involve VBN work_zhhbvy463fhkbjyzltzpvocafu 24 60 . . . work_zhhbvy463fhkbjyzltzpvocafu 25 1 In in IN work_zhhbvy463fhkbjyzltzpvocafu 25 2 this this DT work_zhhbvy463fhkbjyzltzpvocafu 25 3 report report NN work_zhhbvy463fhkbjyzltzpvocafu 25 4 , , , work_zhhbvy463fhkbjyzltzpvocafu 25 5 we -PRON- PRP work_zhhbvy463fhkbjyzltzpvocafu 25 6 describe describe VBP work_zhhbvy463fhkbjyzltzpvocafu 25 7 the the DT work_zhhbvy463fhkbjyzltzpvocafu 25 8 genetic genetic JJ work_zhhbvy463fhkbjyzltzpvocafu 25 9 analysis analysis NN work_zhhbvy463fhkbjyzltzpvocafu 25 10 of of IN work_zhhbvy463fhkbjyzltzpvocafu 25 11 the the DT work_zhhbvy463fhkbjyzltzpvocafu 25 12 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 25 13 and and CC work_zhhbvy463fhkbjyzltzpvocafu 25 14 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 25 15 genes gene NNS work_zhhbvy463fhkbjyzltzpvocafu 25 16 in in IN work_zhhbvy463fhkbjyzltzpvocafu 25 17 a a DT work_zhhbvy463fhkbjyzltzpvocafu 25 18 Taiwanese taiwanese JJ work_zhhbvy463fhkbjyzltzpvocafu 25 19 boy boy NN work_zhhbvy463fhkbjyzltzpvocafu 25 20 with with IN work_zhhbvy463fhkbjyzltzpvocafu 25 21 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 25 22 . . . work_zhhbvy463fhkbjyzltzpvocafu 26 1 Case Case NNP work_zhhbvy463fhkbjyzltzpvocafu 26 2 Report Report NNP work_zhhbvy463fhkbjyzltzpvocafu 26 3 The the DT work_zhhbvy463fhkbjyzltzpvocafu 26 4 proband proband NN work_zhhbvy463fhkbjyzltzpvocafu 26 5 was be VBD work_zhhbvy463fhkbjyzltzpvocafu 26 6 a a DT work_zhhbvy463fhkbjyzltzpvocafu 26 7 1-year 1-year CD work_zhhbvy463fhkbjyzltzpvocafu 26 8 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 26 9 old old JJ work_zhhbvy463fhkbjyzltzpvocafu 26 10 Taiwanese taiwanese JJ work_zhhbvy463fhkbjyzltzpvocafu 26 11 boy boy NN work_zhhbvy463fhkbjyzltzpvocafu 26 12 with with IN work_zhhbvy463fhkbjyzltzpvocafu 26 13 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 26 14 . . . work_zhhbvy463fhkbjyzltzpvocafu 27 1 He -PRON- PRP work_zhhbvy463fhkbjyzltzpvocafu 27 2 presented present VBD work_zhhbvy463fhkbjyzltzpvocafu 27 3 with with IN work_zhhbvy463fhkbjyzltzpvocafu 27 4 abdominal abdominal JJ work_zhhbvy463fhkbjyzltzpvocafu 27 5 dis- dis- NN work_zhhbvy463fhkbjyzltzpvocafu 27 6 tension tension NN work_zhhbvy463fhkbjyzltzpvocafu 27 7 since since IN work_zhhbvy463fhkbjyzltzpvocafu 27 8 birth birth NN work_zhhbvy463fhkbjyzltzpvocafu 27 9 and and CC work_zhhbvy463fhkbjyzltzpvocafu 27 10 bilious bilious JJ work_zhhbvy463fhkbjyzltzpvocafu 27 11 vomiting vomiting NN work_zhhbvy463fhkbjyzltzpvocafu 27 12 after after IN work_zhhbvy463fhkbjyzltzpvocafu 27 13 feeding feed VBG work_zhhbvy463fhkbjyzltzpvocafu 27 14 . . . work_zhhbvy463fhkbjyzltzpvocafu 28 1 The the DT work_zhhbvy463fhkbjyzltzpvocafu 28 2 baby baby NN work_zhhbvy463fhkbjyzltzpvocafu 28 3 was be VBD work_zhhbvy463fhkbjyzltzpvocafu 28 4 born bear VBN work_zhhbvy463fhkbjyzltzpvocafu 28 5 at at IN work_zhhbvy463fhkbjyzltzpvocafu 28 6 full full JJ work_zhhbvy463fhkbjyzltzpvocafu 28 7 term term NN work_zhhbvy463fhkbjyzltzpvocafu 28 8 with with IN work_zhhbvy463fhkbjyzltzpvocafu 28 9 a a DT work_zhhbvy463fhkbjyzltzpvocafu 28 10 birth birth NN work_zhhbvy463fhkbjyzltzpvocafu 28 11 weight weight NN work_zhhbvy463fhkbjyzltzpvocafu 28 12 of of IN work_zhhbvy463fhkbjyzltzpvocafu 28 13 2665 2665 CD work_zhhbvy463fhkbjyzltzpvocafu 28 14 g. g. NNP work_zhhbvy463fhkbjyzltzpvocafu 28 15 He -PRON- PRP work_zhhbvy463fhkbjyzltzpvocafu 28 16 was be VBD work_zhhbvy463fhkbjyzltzpvocafu 28 17 the the DT work_zhhbvy463fhkbjyzltzpvocafu 28 18 first first JJ work_zhhbvy463fhkbjyzltzpvocafu 28 19 child child NN work_zhhbvy463fhkbjyzltzpvocafu 28 20 of of IN work_zhhbvy463fhkbjyzltzpvocafu 28 21 this this DT work_zhhbvy463fhkbjyzltzpvocafu 28 22 family family NN work_zhhbvy463fhkbjyzltzpvocafu 28 23 . . . work_zhhbvy463fhkbjyzltzpvocafu 29 1 No no DT work_zhhbvy463fhkbjyzltzpvocafu 29 2 other other JJ work_zhhbvy463fhkbjyzltzpvocafu 29 3 family family NN work_zhhbvy463fhkbjyzltzpvocafu 29 4 members member NNS work_zhhbvy463fhkbjyzltzpvocafu 29 5 had have VBD work_zhhbvy463fhkbjyzltzpvocafu 29 6 a a DT work_zhhbvy463fhkbjyzltzpvocafu 29 7 his- his- NN work_zhhbvy463fhkbjyzltzpvocafu 29 8 tory tory NN work_zhhbvy463fhkbjyzltzpvocafu 29 9 of of IN work_zhhbvy463fhkbjyzltzpvocafu 29 10 the the DT work_zhhbvy463fhkbjyzltzpvocafu 29 11 same same JJ work_zhhbvy463fhkbjyzltzpvocafu 29 12 symptoms symptom NNS work_zhhbvy463fhkbjyzltzpvocafu 29 13 / / SYM work_zhhbvy463fhkbjyzltzpvocafu 29 14 signs sign NNS work_zhhbvy463fhkbjyzltzpvocafu 29 15 . . . work_zhhbvy463fhkbjyzltzpvocafu 30 1 Table table NN work_zhhbvy463fhkbjyzltzpvocafu 30 2 1 1 CD work_zhhbvy463fhkbjyzltzpvocafu 30 3 . . . work_zhhbvy463fhkbjyzltzpvocafu 31 1 Polymerase polymerase NN work_zhhbvy463fhkbjyzltzpvocafu 31 2 chain chain NN work_zhhbvy463fhkbjyzltzpvocafu 31 3 reaction reaction NN work_zhhbvy463fhkbjyzltzpvocafu 31 4 primers primer NNS work_zhhbvy463fhkbjyzltzpvocafu 31 5 used use VBN work_zhhbvy463fhkbjyzltzpvocafu 31 6 for for IN work_zhhbvy463fhkbjyzltzpvocafu 31 7 the the DT work_zhhbvy463fhkbjyzltzpvocafu 31 8 amplification amplification NN work_zhhbvy463fhkbjyzltzpvocafu 31 9 of of IN work_zhhbvy463fhkbjyzltzpvocafu 31 10 the the DT work_zhhbvy463fhkbjyzltzpvocafu 31 11 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 31 12 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 31 13 from from IN work_zhhbvy463fhkbjyzltzpvocafu 31 14 genomic genomic JJ work_zhhbvy463fhkbjyzltzpvocafu 31 15 DNA DNA NNP work_zhhbvy463fhkbjyzltzpvocafu 31 16 Exon Exon NNP work_zhhbvy463fhkbjyzltzpvocafu 31 17 Forward Forward NNP work_zhhbvy463fhkbjyzltzpvocafu 31 18 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 31 19 5 5 CD work_zhhbvy463fhkbjyzltzpvocafu 31 20 ’ ’ CD work_zhhbvy463fhkbjyzltzpvocafu 31 21 ➔ ➔ CD work_zhhbvy463fhkbjyzltzpvocafu 31 22 3 3 CD work_zhhbvy463fhkbjyzltzpvocafu 31 23 ’ ' '' work_zhhbvy463fhkbjyzltzpvocafu 31 24 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 31 25 Backward Backward NNP work_zhhbvy463fhkbjyzltzpvocafu 31 26 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 31 27 5 5 CD work_zhhbvy463fhkbjyzltzpvocafu 31 28 ’ ’ CD work_zhhbvy463fhkbjyzltzpvocafu 31 29 ➔ ➔ CD work_zhhbvy463fhkbjyzltzpvocafu 31 30 3 3 CD work_zhhbvy463fhkbjyzltzpvocafu 31 31 ’ ' '' work_zhhbvy463fhkbjyzltzpvocafu 31 32 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 31 33 Product product NN work_zhhbvy463fhkbjyzltzpvocafu 31 34 size size NN work_zhhbvy463fhkbjyzltzpvocafu 31 35 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 31 36 bp bp NN work_zhhbvy463fhkbjyzltzpvocafu 31 37 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 31 38 AT AT NNP work_zhhbvy463fhkbjyzltzpvocafu 31 39 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 31 40 ° ° NNP work_zhhbvy463fhkbjyzltzpvocafu 31 41 C C NNP work_zhhbvy463fhkbjyzltzpvocafu 31 42 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 31 43 1 1 CD work_zhhbvy463fhkbjyzltzpvocafu 31 44 CGGCGCTTACCTCGCTTCAG cggcgcttacctcgcttcag NN work_zhhbvy463fhkbjyzltzpvocafu 31 45 TGTCCCGTTTGCTCCAGGAC TGTCCCGTTTGCTCCAGGAC VBZ work_zhhbvy463fhkbjyzltzpvocafu 31 46 622 622 CD work_zhhbvy463fhkbjyzltzpvocafu 31 47 62 62 CD work_zhhbvy463fhkbjyzltzpvocafu 31 48 2 2 CD work_zhhbvy463fhkbjyzltzpvocafu 31 49 CAGTTCTTTTCTAGCCCGTG CAGTTCTTTTCTAGCCCGTG NNP work_zhhbvy463fhkbjyzltzpvocafu 31 50 ATGATTCCCGTGTGTCTCCA ATGATTCCCGTGTGTCTCCA NNP work_zhhbvy463fhkbjyzltzpvocafu 31 51 671 671 CD work_zhhbvy463fhkbjyzltzpvocafu 31 52 52 52 CD work_zhhbvy463fhkbjyzltzpvocafu 31 53 3 3 CD work_zhhbvy463fhkbjyzltzpvocafu 31 54 GTTTACACCAGCCCTGGAGC GTTTACACCAGCCCTGGAGC NNP work_zhhbvy463fhkbjyzltzpvocafu 31 55 GCTCTGTCTGCCCCACAAGA GCTCTGTCTGCCCCACAAGA NNS work_zhhbvy463fhkbjyzltzpvocafu 31 56 631 631 CD work_zhhbvy463fhkbjyzltzpvocafu 31 57 55 55 CD work_zhhbvy463fhkbjyzltzpvocafu 31 58 4 4 CD work_zhhbvy463fhkbjyzltzpvocafu 31 59 CTGTGGAGCGGAGGAGGGGA CTGTGGAGCGGAGGAGGGGA NNP work_zhhbvy463fhkbjyzltzpvocafu 31 60 CTAGGACAGACGGCGCAGAC CTAGGACAGACGGCGCAGAC NNP work_zhhbvy463fhkbjyzltzpvocafu 31 61 534 534 CD work_zhhbvy463fhkbjyzltzpvocafu 31 62 62 62 CD work_zhhbvy463fhkbjyzltzpvocafu 31 63 5 5 CD work_zhhbvy463fhkbjyzltzpvocafu 31 64 CTGACAACACACATCTGGTC CTGACAACACACATCTGGTC NNP work_zhhbvy463fhkbjyzltzpvocafu 31 65 CAGAGACACAGGAAGTGCTG CAGAGACACAGGAAGTGCTG NNP work_zhhbvy463fhkbjyzltzpvocafu 31 66 481 481 CD work_zhhbvy463fhkbjyzltzpvocafu 31 67 55 55 CD work_zhhbvy463fhkbjyzltzpvocafu 31 68 6 6 CD work_zhhbvy463fhkbjyzltzpvocafu 31 69 CGTGTTTGCACCAGTGTGAG CGTGTTTGCACCAGTGTGAG NNP work_zhhbvy463fhkbjyzltzpvocafu 31 70 CACCCAGTCTACTCTGTGCT CACCCAGTCTACTCTGTGCT NNP work_zhhbvy463fhkbjyzltzpvocafu 31 71 401 401 CD work_zhhbvy463fhkbjyzltzpvocafu 31 72 53 53 CD work_zhhbvy463fhkbjyzltzpvocafu 31 73 7 7 CD work_zhhbvy463fhkbjyzltzpvocafu 31 74 GTTCCAGGACTTAGGCTGTG GTTCCAGGACTTAGGCTGTG NNP work_zhhbvy463fhkbjyzltzpvocafu 31 75 AGCCTTGCAGCTGTACTGCT AGCCTTGCAGCTGTACTGCT NNP work_zhhbvy463fhkbjyzltzpvocafu 31 76 449 449 CD work_zhhbvy463fhkbjyzltzpvocafu 31 77 53 53 CD work_zhhbvy463fhkbjyzltzpvocafu 31 78 8 8 CD work_zhhbvy463fhkbjyzltzpvocafu 31 79 CTGGCACTGTCTTTGCTGCC CTGGCACTGTCTTTGCTGCC NNP work_zhhbvy463fhkbjyzltzpvocafu 31 80 CTCACAAGCCCTCTCCCAAG CTCACAAGCCCTCTCCCAAG VBD work_zhhbvy463fhkbjyzltzpvocafu 31 81 468 468 CD work_zhhbvy463fhkbjyzltzpvocafu 31 82 55 55 CD work_zhhbvy463fhkbjyzltzpvocafu 31 83 9 9 CD work_zhhbvy463fhkbjyzltzpvocafu 31 84 CTCCTCTCCCATAAGCCATG ctcctctcccataagccatg NN work_zhhbvy463fhkbjyzltzpvocafu 31 85 GAACTGACAGCCCTGGCAAC GAACTGACAGCCCTGGCAAC NNP work_zhhbvy463fhkbjyzltzpvocafu 31 86 391 391 CD work_zhhbvy463fhkbjyzltzpvocafu 31 87 55 55 CD work_zhhbvy463fhkbjyzltzpvocafu 31 88 10 10 CD work_zhhbvy463fhkbjyzltzpvocafu 31 89 CAGAAAGGCACTGTGACCAA CAGAAAGGCACTGTGACCAA NNP work_zhhbvy463fhkbjyzltzpvocafu 31 90 CAGGCTGACAAGTTGTTTGG CAGGCTGACAAGTTGTTTGG NNP work_zhhbvy463fhkbjyzltzpvocafu 31 91 554 554 CD work_zhhbvy463fhkbjyzltzpvocafu 31 92 52 52 CD work_zhhbvy463fhkbjyzltzpvocafu 31 93 11 11 CD work_zhhbvy463fhkbjyzltzpvocafu 31 94 GTAAATGGCAGTACCCATGC GTAAATGGCAGTACCCATGC NNS work_zhhbvy463fhkbjyzltzpvocafu 31 95 CACAGCGCCCTATGGAAATG CACAGCGCCCTATGGAAATG NNP work_zhhbvy463fhkbjyzltzpvocafu 31 96 592 592 CD work_zhhbvy463fhkbjyzltzpvocafu 31 97 52 52 CD work_zhhbvy463fhkbjyzltzpvocafu 31 98 12 12 CD work_zhhbvy463fhkbjyzltzpvocafu 31 99 GCAGAGACAGGCAGCGTTGC GCAGAGACAGGCAGCGTTGC NNP work_zhhbvy463fhkbjyzltzpvocafu 31 100 CTCGCTCTGCTTCTCTAGGC CTCGCTCTGCTTCTCTAGGC NNP work_zhhbvy463fhkbjyzltzpvocafu 31 101 458 458 CD work_zhhbvy463fhkbjyzltzpvocafu 31 102 55 55 CD work_zhhbvy463fhkbjyzltzpvocafu 31 103 13 13 CD work_zhhbvy463fhkbjyzltzpvocafu 31 104 CTCTCTGTCTGAACTTGGGC CTCTCTGTCTGAACTTGGGC NNS work_zhhbvy463fhkbjyzltzpvocafu 31 105 CAGTAGGGAAAGGGAGAAAG CAGTAGGGAAAGGGAGAAAG NNP work_zhhbvy463fhkbjyzltzpvocafu 31 106 312 312 CD work_zhhbvy463fhkbjyzltzpvocafu 31 107 52 52 CD work_zhhbvy463fhkbjyzltzpvocafu 31 108 14 14 CD work_zhhbvy463fhkbjyzltzpvocafu 31 109 CAGAGCTGCAGCAGTGCTGC CAGAGCTGCAGCAGTGCTGC NNP work_zhhbvy463fhkbjyzltzpvocafu 31 110 CATGCCATGGCAGGGGCATG CATGCCATGGCAGGGGCATG NNP work_zhhbvy463fhkbjyzltzpvocafu 31 111 508 508 CD work_zhhbvy463fhkbjyzltzpvocafu 31 112 52 52 CD work_zhhbvy463fhkbjyzltzpvocafu 31 113 15 15 CD work_zhhbvy463fhkbjyzltzpvocafu 31 114 CTGCCATGTCACACCCTGAC ctgccatgtcacaccctgac NN work_zhhbvy463fhkbjyzltzpvocafu 31 115 GTCAGTATGCTGCCAGGGAG GTCAGTATGCTGCCAGGGAG NNP work_zhhbvy463fhkbjyzltzpvocafu 31 116 540 540 CD work_zhhbvy463fhkbjyzltzpvocafu 31 117 57 57 CD work_zhhbvy463fhkbjyzltzpvocafu 31 118 16 16 CD work_zhhbvy463fhkbjyzltzpvocafu 31 119 CAGGAGTGTCTACAGCACTC CAGGAGTGTCTACAGCACTC NNP work_zhhbvy463fhkbjyzltzpvocafu 31 120 CATTGCAGAGGGCTAGCACT CATTGCAGAGGGCTAGCACT NNP work_zhhbvy463fhkbjyzltzpvocafu 31 121 340 340 CD work_zhhbvy463fhkbjyzltzpvocafu 31 122 53 53 CD work_zhhbvy463fhkbjyzltzpvocafu 31 123 17 17 CD work_zhhbvy463fhkbjyzltzpvocafu 31 124 CGACAGGGTCAGCAGGTGCT CGACAGGGTCAGCAGGTGCT NNP work_zhhbvy463fhkbjyzltzpvocafu 31 125 CTGGTTTCTCCTGGGGCTGC CTGGTTTCTCCTGGGGCTGC NNP work_zhhbvy463fhkbjyzltzpvocafu 31 126 341 341 CD work_zhhbvy463fhkbjyzltzpvocafu 31 127 58 58 CD work_zhhbvy463fhkbjyzltzpvocafu 31 128 18 18 CD work_zhhbvy463fhkbjyzltzpvocafu 31 129 CTTTGGAGTTGGAGACAGAG CTTTGGAGTTGGAGACAGAG NNP work_zhhbvy463fhkbjyzltzpvocafu 31 130 CATGACTCTCTCTCTCTGCA CATGACTCTCTCTCTCTGCA NNP work_zhhbvy463fhkbjyzltzpvocafu 31 131 361 361 CD work_zhhbvy463fhkbjyzltzpvocafu 31 132 50 50 CD work_zhhbvy463fhkbjyzltzpvocafu 31 133 19 19 CD work_zhhbvy463fhkbjyzltzpvocafu 31 134 CTGGTCTCTTGGAGAGGTCA ctggtctcttggagaggtca NN work_zhhbvy463fhkbjyzltzpvocafu 31 135 GGTTCAGAGCAGACTTTGGT GGTTCAGAGCAGACTTTGGT NNP work_zhhbvy463fhkbjyzltzpvocafu 31 136 411 411 CD work_zhhbvy463fhkbjyzltzpvocafu 31 137 50 50 CD work_zhhbvy463fhkbjyzltzpvocafu 31 138 20 20 CD work_zhhbvy463fhkbjyzltzpvocafu 31 139 CACAGAAACCACGAGTTTGG CACAGAAACCACGAGTTTGG NNS work_zhhbvy463fhkbjyzltzpvocafu 31 140 CTGCTAGGAGGGAAAATCAC CTGCTAGGAGGGAAAATCAC NNP work_zhhbvy463fhkbjyzltzpvocafu 31 141 470 470 CD work_zhhbvy463fhkbjyzltzpvocafu 31 142 50 50 CD work_zhhbvy463fhkbjyzltzpvocafu 31 143 AT at IN work_zhhbvy463fhkbjyzltzpvocafu 31 144 = = SYM work_zhhbvy463fhkbjyzltzpvocafu 31 145 annealing anneal VBG work_zhhbvy463fhkbjyzltzpvocafu 31 146 temperature temperature NN work_zhhbvy463fhkbjyzltzpvocafu 31 147 . . . work_zhhbvy463fhkbjyzltzpvocafu 32 1 351J 351j CD work_zhhbvy463fhkbjyzltzpvocafu 32 2 Formos Formos NNP work_zhhbvy463fhkbjyzltzpvocafu 32 3 Med Med NNP work_zhhbvy463fhkbjyzltzpvocafu 32 4 Assoc Assoc NNP work_zhhbvy463fhkbjyzltzpvocafu 32 5 | | CD work_zhhbvy463fhkbjyzltzpvocafu 32 6 2006 2006 CD work_zhhbvy463fhkbjyzltzpvocafu 32 7 • • NNP work_zhhbvy463fhkbjyzltzpvocafu 32 8 Vol Vol NNP work_zhhbvy463fhkbjyzltzpvocafu 32 9 105 105 CD work_zhhbvy463fhkbjyzltzpvocafu 32 10 • • NNP work_zhhbvy463fhkbjyzltzpvocafu 32 11 No no DT work_zhhbvy463fhkbjyzltzpvocafu 32 12 4 4 CD work_zhhbvy463fhkbjyzltzpvocafu 32 13 EDNRB ednrb NN work_zhhbvy463fhkbjyzltzpvocafu 32 14 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 32 15 in in IN work_zhhbvy463fhkbjyzltzpvocafu 32 16 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 32 17 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 32 18 For for IN work_zhhbvy463fhkbjyzltzpvocafu 32 19 polymerase polymerase NN work_zhhbvy463fhkbjyzltzpvocafu 32 20 chain chain NN work_zhhbvy463fhkbjyzltzpvocafu 32 21 reaction reaction NN work_zhhbvy463fhkbjyzltzpvocafu 32 22 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 32 23 PCR PCR NNP work_zhhbvy463fhkbjyzltzpvocafu 32 24 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 32 25 amplifi- amplifi- NNP work_zhhbvy463fhkbjyzltzpvocafu 32 26 cation cation NN work_zhhbvy463fhkbjyzltzpvocafu 32 27 , , , work_zhhbvy463fhkbjyzltzpvocafu 32 28 approximately approximately RB work_zhhbvy463fhkbjyzltzpvocafu 32 29 200 200 CD work_zhhbvy463fhkbjyzltzpvocafu 32 30 ng ng NN work_zhhbvy463fhkbjyzltzpvocafu 32 31 of of IN work_zhhbvy463fhkbjyzltzpvocafu 32 32 genomic genomic JJ work_zhhbvy463fhkbjyzltzpvocafu 32 33 DNA dna NN work_zhhbvy463fhkbjyzltzpvocafu 32 34 , , , work_zhhbvy463fhkbjyzltzpvocafu 32 35 12.8 12.8 CD work_zhhbvy463fhkbjyzltzpvocafu 32 36 pmol pmol NN work_zhhbvy463fhkbjyzltzpvocafu 32 37 of of IN work_zhhbvy463fhkbjyzltzpvocafu 32 38 each each DT work_zhhbvy463fhkbjyzltzpvocafu 32 39 primer primer NN work_zhhbvy463fhkbjyzltzpvocafu 32 40 , , , work_zhhbvy463fhkbjyzltzpvocafu 32 41 10 10 CD work_zhhbvy463fhkbjyzltzpvocafu 32 42 μmol μmol JJ work_zhhbvy463fhkbjyzltzpvocafu 32 43 dNTP dntp NN work_zhhbvy463fhkbjyzltzpvocafu 32 44 and and CC work_zhhbvy463fhkbjyzltzpvocafu 32 45 1.25 1.25 CD work_zhhbvy463fhkbjyzltzpvocafu 32 46 U u NN work_zhhbvy463fhkbjyzltzpvocafu 32 47 of of IN work_zhhbvy463fhkbjyzltzpvocafu 32 48 Taq Taq NNP work_zhhbvy463fhkbjyzltzpvocafu 32 49 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 32 50 Qiagen Qiagen NNP work_zhhbvy463fhkbjyzltzpvocafu 32 51 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 32 52 were be VBD work_zhhbvy463fhkbjyzltzpvocafu 32 53 used use VBN work_zhhbvy463fhkbjyzltzpvocafu 32 54 in in IN work_zhhbvy463fhkbjyzltzpvocafu 32 55 a a DT work_zhhbvy463fhkbjyzltzpvocafu 32 56 total total JJ work_zhhbvy463fhkbjyzltzpvocafu 32 57 vol- vol- JJ work_zhhbvy463fhkbjyzltzpvocafu 32 58 ume ume NN work_zhhbvy463fhkbjyzltzpvocafu 32 59 of of IN work_zhhbvy463fhkbjyzltzpvocafu 32 60 50 50 CD work_zhhbvy463fhkbjyzltzpvocafu 32 61 μL. μL. NNS work_zhhbvy463fhkbjyzltzpvocafu 33 1 The the DT work_zhhbvy463fhkbjyzltzpvocafu 33 2 amplification amplification NN work_zhhbvy463fhkbjyzltzpvocafu 33 3 conditions condition NNS work_zhhbvy463fhkbjyzltzpvocafu 33 4 were be VBD work_zhhbvy463fhkbjyzltzpvocafu 33 5 94 94 CD work_zhhbvy463fhkbjyzltzpvocafu 33 6 ° ° , work_zhhbvy463fhkbjyzltzpvocafu 33 7 C C NNP work_zhhbvy463fhkbjyzltzpvocafu 33 8 for for IN work_zhhbvy463fhkbjyzltzpvocafu 33 9 5 5 CD work_zhhbvy463fhkbjyzltzpvocafu 33 10 minutes minute NNS work_zhhbvy463fhkbjyzltzpvocafu 33 11 , , , work_zhhbvy463fhkbjyzltzpvocafu 33 12 followed follow VBN work_zhhbvy463fhkbjyzltzpvocafu 33 13 by by IN work_zhhbvy463fhkbjyzltzpvocafu 33 14 40 40 CD work_zhhbvy463fhkbjyzltzpvocafu 33 15 cycles cycle NNS work_zhhbvy463fhkbjyzltzpvocafu 33 16 of of IN work_zhhbvy463fhkbjyzltzpvocafu 33 17 94 94 CD work_zhhbvy463fhkbjyzltzpvocafu 33 18 ° ° , work_zhhbvy463fhkbjyzltzpvocafu 33 19 C C NNP work_zhhbvy463fhkbjyzltzpvocafu 33 20 for for IN work_zhhbvy463fhkbjyzltzpvocafu 33 21 45 45 CD work_zhhbvy463fhkbjyzltzpvocafu 33 22 seconds second NNS work_zhhbvy463fhkbjyzltzpvocafu 33 23 , , , work_zhhbvy463fhkbjyzltzpvocafu 33 24 annealing anneal VBG work_zhhbvy463fhkbjyzltzpvocafu 33 25 temperature temperature NN work_zhhbvy463fhkbjyzltzpvocafu 33 26 for for IN work_zhhbvy463fhkbjyzltzpvocafu 33 27 45 45 CD work_zhhbvy463fhkbjyzltzpvocafu 33 28 seconds second NNS work_zhhbvy463fhkbjyzltzpvocafu 33 29 and and CC work_zhhbvy463fhkbjyzltzpvocafu 33 30 72 72 CD work_zhhbvy463fhkbjyzltzpvocafu 33 31 ° ° , work_zhhbvy463fhkbjyzltzpvocafu 33 32 C C NNP work_zhhbvy463fhkbjyzltzpvocafu 33 33 for for IN work_zhhbvy463fhkbjyzltzpvocafu 33 34 45 45 CD work_zhhbvy463fhkbjyzltzpvocafu 33 35 seconds second NNS work_zhhbvy463fhkbjyzltzpvocafu 33 36 , , , work_zhhbvy463fhkbjyzltzpvocafu 33 37 and and CC work_zhhbvy463fhkbjyzltzpvocafu 33 38 extension extension NN work_zhhbvy463fhkbjyzltzpvocafu 33 39 at at IN work_zhhbvy463fhkbjyzltzpvocafu 33 40 72 72 CD work_zhhbvy463fhkbjyzltzpvocafu 33 41 ° ° NNS work_zhhbvy463fhkbjyzltzpvocafu 33 42 C C NNP work_zhhbvy463fhkbjyzltzpvocafu 33 43 for for IN work_zhhbvy463fhkbjyzltzpvocafu 33 44 10 10 CD work_zhhbvy463fhkbjyzltzpvocafu 33 45 minutes minute NNS work_zhhbvy463fhkbjyzltzpvocafu 33 46 . . . work_zhhbvy463fhkbjyzltzpvocafu 34 1 PCR PCR NNP work_zhhbvy463fhkbjyzltzpvocafu 34 2 products product NNS work_zhhbvy463fhkbjyzltzpvocafu 34 3 were be VBD work_zhhbvy463fhkbjyzltzpvocafu 34 4 puri- puri- RB work_zhhbvy463fhkbjyzltzpvocafu 34 5 fied fie VBN work_zhhbvy463fhkbjyzltzpvocafu 34 6 by by IN work_zhhbvy463fhkbjyzltzpvocafu 34 7 QIAquick QIAquick NNP work_zhhbvy463fhkbjyzltzpvocafu 34 8 columns column NNS work_zhhbvy463fhkbjyzltzpvocafu 34 9 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 34 10 Qiagen Qiagen NNP work_zhhbvy463fhkbjyzltzpvocafu 34 11 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 34 12 and and CC work_zhhbvy463fhkbjyzltzpvocafu 34 13 sequenced sequence VBN work_zhhbvy463fhkbjyzltzpvocafu 34 14 with with IN work_zhhbvy463fhkbjyzltzpvocafu 34 15 both both CC work_zhhbvy463fhkbjyzltzpvocafu 34 16 forward forward JJ work_zhhbvy463fhkbjyzltzpvocafu 34 17 and and CC work_zhhbvy463fhkbjyzltzpvocafu 34 18 backward backward JJ work_zhhbvy463fhkbjyzltzpvocafu 34 19 primers primer NNS work_zhhbvy463fhkbjyzltzpvocafu 34 20 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 34 21 377 377 CD work_zhhbvy463fhkbjyzltzpvocafu 34 22 ABI ABI NNP work_zhhbvy463fhkbjyzltzpvocafu 34 23 Advanced Advanced NNP work_zhhbvy463fhkbjyzltzpvocafu 34 24 Biotechnologies Biotechnologies NNPS work_zhhbvy463fhkbjyzltzpvocafu 34 25 , , , work_zhhbvy463fhkbjyzltzpvocafu 34 26 Columbia Columbia NNP work_zhhbvy463fhkbjyzltzpvocafu 34 27 , , , work_zhhbvy463fhkbjyzltzpvocafu 34 28 MD MD NNP work_zhhbvy463fhkbjyzltzpvocafu 34 29 , , , work_zhhbvy463fhkbjyzltzpvocafu 34 30 USA USA NNP work_zhhbvy463fhkbjyzltzpvocafu 34 31 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 34 32 . . . work_zhhbvy463fhkbjyzltzpvocafu 35 1 Automated Automated NNP work_zhhbvy463fhkbjyzltzpvocafu 35 2 DNA DNA NNP work_zhhbvy463fhkbjyzltzpvocafu 35 3 sequencing sequencing NN work_zhhbvy463fhkbjyzltzpvocafu 35 4 of of IN work_zhhbvy463fhkbjyzltzpvocafu 35 5 the the DT work_zhhbvy463fhkbjyzltzpvocafu 35 6 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 35 7 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 35 8 revealed reveal VBD work_zhhbvy463fhkbjyzltzpvocafu 35 9 a a DT work_zhhbvy463fhkbjyzltzpvocafu 35 10 heterozygous heterozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 35 11 T t NN work_zhhbvy463fhkbjyzltzpvocafu 35 12 to to IN work_zhhbvy463fhkbjyzltzpvocafu 35 13 C c NN work_zhhbvy463fhkbjyzltzpvocafu 35 14 transition transition NN work_zhhbvy463fhkbjyzltzpvocafu 35 15 of of IN work_zhhbvy463fhkbjyzltzpvocafu 35 16 codon codon NNP work_zhhbvy463fhkbjyzltzpvocafu 35 17 90 90 CD work_zhhbvy463fhkbjyzltzpvocafu 35 18 in in IN work_zhhbvy463fhkbjyzltzpvocafu 35 19 exon exon NNP work_zhhbvy463fhkbjyzltzpvocafu 35 20 1 1 CD work_zhhbvy463fhkbjyzltzpvocafu 35 21 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 35 22 Figure Figure NNP work_zhhbvy463fhkbjyzltzpvocafu 35 23 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 35 24 , , , work_zhhbvy463fhkbjyzltzpvocafu 35 25 which which WDT work_zhhbvy463fhkbjyzltzpvocafu 35 26 predicted predict VBD work_zhhbvy463fhkbjyzltzpvocafu 35 27 a a DT work_zhhbvy463fhkbjyzltzpvocafu 35 28 substitution substitution NN work_zhhbvy463fhkbjyzltzpvocafu 35 29 of of IN work_zhhbvy463fhkbjyzltzpvocafu 35 30 cysteine cysteine NN work_zhhbvy463fhkbjyzltzpvocafu 35 31 by by IN work_zhhbvy463fhkbjyzltzpvocafu 35 32 arginine arginine NNP work_zhhbvy463fhkbjyzltzpvocafu 35 33 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 35 34 C90R C90R NNP work_zhhbvy463fhkbjyzltzpvocafu 35 35 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 35 36 . . . work_zhhbvy463fhkbjyzltzpvocafu 36 1 This this DT work_zhhbvy463fhkbjyzltzpvocafu 36 2 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 36 3 was be VBD work_zhhbvy463fhkbjyzltzpvocafu 36 4 confirmed confirm VBN work_zhhbvy463fhkbjyzltzpvocafu 36 5 with with IN work_zhhbvy463fhkbjyzltzpvocafu 36 6 backward backward JJ work_zhhbvy463fhkbjyzltzpvocafu 36 7 primer primer NNP work_zhhbvy463fhkbjyzltzpvocafu 36 8 for for IN work_zhhbvy463fhkbjyzltzpvocafu 36 9 exon exon NNP work_zhhbvy463fhkbjyzltzpvocafu 36 10 1 1 CD work_zhhbvy463fhkbjyzltzpvocafu 36 11 . . . work_zhhbvy463fhkbjyzltzpvocafu 37 1 Neither neither DT work_zhhbvy463fhkbjyzltzpvocafu 37 2 of of IN work_zhhbvy463fhkbjyzltzpvocafu 37 3 the the DT work_zhhbvy463fhkbjyzltzpvocafu 37 4 parents parent NNS work_zhhbvy463fhkbjyzltzpvocafu 37 5 had have VBD work_zhhbvy463fhkbjyzltzpvocafu 37 6 this this DT work_zhhbvy463fhkbjyzltzpvocafu 37 7 mu- mu- JJ work_zhhbvy463fhkbjyzltzpvocafu 37 8 tation tation NN work_zhhbvy463fhkbjyzltzpvocafu 37 9 . . . work_zhhbvy463fhkbjyzltzpvocafu 38 1 The the DT work_zhhbvy463fhkbjyzltzpvocafu 38 2 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 38 3 created create VBD work_zhhbvy463fhkbjyzltzpvocafu 38 4 a a DT work_zhhbvy463fhkbjyzltzpvocafu 38 5 new new JJ work_zhhbvy463fhkbjyzltzpvocafu 38 6 restriction restriction NN work_zhhbvy463fhkbjyzltzpvocafu 38 7 en- en- IN work_zhhbvy463fhkbjyzltzpvocafu 38 8 zyme zyme NNS work_zhhbvy463fhkbjyzltzpvocafu 38 9 site site NN work_zhhbvy463fhkbjyzltzpvocafu 38 10 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 38 11 AciI AciI NNP work_zhhbvy463fhkbjyzltzpvocafu 38 12 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 38 13 . . . work_zhhbvy463fhkbjyzltzpvocafu 39 1 The the DT work_zhhbvy463fhkbjyzltzpvocafu 39 2 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 39 3 was be VBD work_zhhbvy463fhkbjyzltzpvocafu 39 4 absent absent JJ work_zhhbvy463fhkbjyzltzpvocafu 39 5 in in IN work_zhhbvy463fhkbjyzltzpvocafu 39 6 100 100 CD work_zhhbvy463fhkbjyzltzpvocafu 39 7 normal normal JJ work_zhhbvy463fhkbjyzltzpvocafu 39 8 unrelated unrelated JJ work_zhhbvy463fhkbjyzltzpvocafu 39 9 Taiwanese taiwanese JJ work_zhhbvy463fhkbjyzltzpvocafu 39 10 controls control NNS work_zhhbvy463fhkbjyzltzpvocafu 39 11 by by IN work_zhhbvy463fhkbjyzltzpvocafu 39 12 restric- restric- NNP work_zhhbvy463fhkbjyzltzpvocafu 39 13 tion tion NN work_zhhbvy463fhkbjyzltzpvocafu 39 14 fragment fragment NN work_zhhbvy463fhkbjyzltzpvocafu 39 15 analysis analysis NN work_zhhbvy463fhkbjyzltzpvocafu 39 16 , , , work_zhhbvy463fhkbjyzltzpvocafu 39 17 indicating indicate VBG work_zhhbvy463fhkbjyzltzpvocafu 39 18 that that IN work_zhhbvy463fhkbjyzltzpvocafu 39 19 it -PRON- PRP work_zhhbvy463fhkbjyzltzpvocafu 39 20 was be VBD work_zhhbvy463fhkbjyzltzpvocafu 39 21 not not RB work_zhhbvy463fhkbjyzltzpvocafu 39 22 a a DT work_zhhbvy463fhkbjyzltzpvocafu 39 23 polymorphism polymorphism NN work_zhhbvy463fhkbjyzltzpvocafu 39 24 . . . work_zhhbvy463fhkbjyzltzpvocafu 40 1 No no DT work_zhhbvy463fhkbjyzltzpvocafu 40 2 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 40 3 was be VBD work_zhhbvy463fhkbjyzltzpvocafu 40 4 detected detect VBN work_zhhbvy463fhkbjyzltzpvocafu 40 5 in in IN work_zhhbvy463fhkbjyzltzpvocafu 40 6 the the DT work_zhhbvy463fhkbjyzltzpvocafu 40 7 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 40 8 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 40 9 of of IN work_zhhbvy463fhkbjyzltzpvocafu 40 10 this this DT work_zhhbvy463fhkbjyzltzpvocafu 40 11 patient patient NN work_zhhbvy463fhkbjyzltzpvocafu 40 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 41 1 Discussion Discussion NNP work_zhhbvy463fhkbjyzltzpvocafu 41 2 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 41 3 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 41 4 a a DT work_zhhbvy463fhkbjyzltzpvocafu 41 5 frequent frequent JJ work_zhhbvy463fhkbjyzltzpvocafu 41 6 neurocristopathy10 neurocristopathy10 HYPH work_zhhbvy463fhkbjyzltzpvocafu 41 7 character- character- NN work_zhhbvy463fhkbjyzltzpvocafu 41 8 ized ize VBN work_zhhbvy463fhkbjyzltzpvocafu 41 9 by by IN work_zhhbvy463fhkbjyzltzpvocafu 41 10 the the DT work_zhhbvy463fhkbjyzltzpvocafu 41 11 absence absence NN work_zhhbvy463fhkbjyzltzpvocafu 41 12 of of IN work_zhhbvy463fhkbjyzltzpvocafu 41 13 submucosal submucosal NN work_zhhbvy463fhkbjyzltzpvocafu 41 14 and and CC work_zhhbvy463fhkbjyzltzpvocafu 41 15 myenteric myenteric JJ work_zhhbvy463fhkbjyzltzpvocafu 41 16 plexus plexus NN work_zhhbvy463fhkbjyzltzpvocafu 41 17 in in IN work_zhhbvy463fhkbjyzltzpvocafu 41 18 a a DT work_zhhbvy463fhkbjyzltzpvocafu 41 19 variable variable JJ work_zhhbvy463fhkbjyzltzpvocafu 41 20 length length NN work_zhhbvy463fhkbjyzltzpvocafu 41 21 of of IN work_zhhbvy463fhkbjyzltzpvocafu 41 22 the the DT work_zhhbvy463fhkbjyzltzpvocafu 41 23 gastrointestinal gastrointestinal JJ work_zhhbvy463fhkbjyzltzpvocafu 41 24 tract tract NN work_zhhbvy463fhkbjyzltzpvocafu 41 25 . . . work_zhhbvy463fhkbjyzltzpvocafu 42 1 In in IN work_zhhbvy463fhkbjyzltzpvocafu 42 2 the the DT work_zhhbvy463fhkbjyzltzpvocafu 42 3 vast vast JJ work_zhhbvy463fhkbjyzltzpvocafu 42 4 majority majority NN work_zhhbvy463fhkbjyzltzpvocafu 42 5 of of IN work_zhhbvy463fhkbjyzltzpvocafu 42 6 cases case NNS work_zhhbvy463fhkbjyzltzpvocafu 42 7 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 42 8 80 80 CD work_zhhbvy463fhkbjyzltzpvocafu 42 9 % % NN work_zhhbvy463fhkbjyzltzpvocafu 42 10 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 42 11 , , , work_zhhbvy463fhkbjyzltzpvocafu 42 12 the the DT work_zhhbvy463fhkbjyzltzpvocafu 42 13 agan- agan- XX work_zhhbvy463fhkbjyzltzpvocafu 42 14 glionic glionic JJ work_zhhbvy463fhkbjyzltzpvocafu 42 15 tract tract NN work_zhhbvy463fhkbjyzltzpvocafu 42 16 involves involve VBZ work_zhhbvy463fhkbjyzltzpvocafu 42 17 the the DT work_zhhbvy463fhkbjyzltzpvocafu 42 18 rectum rectum NN work_zhhbvy463fhkbjyzltzpvocafu 42 19 and and CC work_zhhbvy463fhkbjyzltzpvocafu 42 20 the the DT work_zhhbvy463fhkbjyzltzpvocafu 42 21 sigmoid sigmoid JJ work_zhhbvy463fhkbjyzltzpvocafu 42 22 colon colon NN work_zhhbvy463fhkbjyzltzpvocafu 42 23 only only RB work_zhhbvy463fhkbjyzltzpvocafu 42 24 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 42 25 short short JJ work_zhhbvy463fhkbjyzltzpvocafu 42 26 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 42 27 segment segment NN work_zhhbvy463fhkbjyzltzpvocafu 42 28 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 42 29 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 42 30 , , , work_zhhbvy463fhkbjyzltzpvocafu 42 31 while while IN work_zhhbvy463fhkbjyzltzpvocafu 42 32 in in IN work_zhhbvy463fhkbjyzltzpvocafu 42 33 20 20 CD work_zhhbvy463fhkbjyzltzpvocafu 42 34 % % NN work_zhhbvy463fhkbjyzltzpvocafu 42 35 of of IN work_zhhbvy463fhkbjyzltzpvocafu 42 36 cases case NNS work_zhhbvy463fhkbjyzltzpvocafu 42 37 , , , work_zhhbvy463fhkbjyzltzpvocafu 42 38 it -PRON- PRP work_zhhbvy463fhkbjyzltzpvocafu 42 39 extends extend VBZ work_zhhbvy463fhkbjyzltzpvocafu 42 40 towards towards IN work_zhhbvy463fhkbjyzltzpvocafu 42 41 the the DT work_zhhbvy463fhkbjyzltzpvocafu 42 42 proximal proximal JJ work_zhhbvy463fhkbjyzltzpvocafu 42 43 end end NN work_zhhbvy463fhkbjyzltzpvocafu 42 44 of of IN work_zhhbvy463fhkbjyzltzpvocafu 42 45 the the DT work_zhhbvy463fhkbjyzltzpvocafu 42 46 colon.11 colon.11 NNP work_zhhbvy463fhkbjyzltzpvocafu 42 47 Although although IN work_zhhbvy463fhkbjyzltzpvocafu 42 48 80 80 CD work_zhhbvy463fhkbjyzltzpvocafu 42 49 % % NN work_zhhbvy463fhkbjyzltzpvocafu 42 50 of of IN work_zhhbvy463fhkbjyzltzpvocafu 42 51 cases case NNS work_zhhbvy463fhkbjyzltzpvocafu 42 52 are be VBP work_zhhbvy463fhkbjyzltzpvocafu 42 53 sporadic sporadic JJ work_zhhbvy463fhkbjyzltzpvocafu 42 54 , , , work_zhhbvy463fhkbjyzltzpvocafu 42 55 pedigree pedigree JJ work_zhhbvy463fhkbjyzltzpvocafu 42 56 and and CC work_zhhbvy463fhkbjyzltzpvocafu 42 57 segregation segregation NN work_zhhbvy463fhkbjyzltzpvocafu 42 58 analyses analysis NNS work_zhhbvy463fhkbjyzltzpvocafu 42 59 suggested suggest VBD work_zhhbvy463fhkbjyzltzpvocafu 42 60 the the DT work_zhhbvy463fhkbjyzltzpvocafu 42 61 involvement involvement NN work_zhhbvy463fhkbjyzltzpvocafu 42 62 of of IN work_zhhbvy463fhkbjyzltzpvocafu 42 63 one one CD work_zhhbvy463fhkbjyzltzpvocafu 42 64 or or CC work_zhhbvy463fhkbjyzltzpvocafu 42 65 several several JJ work_zhhbvy463fhkbjyzltzpvocafu 42 66 dominant dominant JJ work_zhhbvy463fhkbjyzltzpvocafu 42 67 genes gene NNS work_zhhbvy463fhkbjyzltzpvocafu 42 68 with with IN work_zhhbvy463fhkbjyzltzpvocafu 42 69 low low JJ work_zhhbvy463fhkbjyzltzpvocafu 42 70 penetrance penetrance NN work_zhhbvy463fhkbjyzltzpvocafu 42 71 in in IN work_zhhbvy463fhkbjyzltzpvocafu 42 72 HSCR.12 hscr.12 CD work_zhhbvy463fhkbjyzltzpvocafu 42 73 A a DT work_zhhbvy463fhkbjyzltzpvocafu 42 74 major major JJ work_zhhbvy463fhkbjyzltzpvocafu 42 75 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 42 76 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 42 77 has have VBZ work_zhhbvy463fhkbjyzltzpvocafu 42 78 been be VBN work_zhhbvy463fhkbjyzltzpvocafu 42 79 mapped map VBN work_zhhbvy463fhkbjyzltzpvocafu 42 80 to to TO work_zhhbvy463fhkbjyzltzpvocafu 42 81 chromosome chromosome VB work_zhhbvy463fhkbjyzltzpvocafu 42 82 10q11.2 10q11.2 NN work_zhhbvy463fhkbjyzltzpvocafu 42 83 , , , work_zhhbvy463fhkbjyzltzpvocafu 42 84 and and CC work_zhhbvy463fhkbjyzltzpvocafu 42 85 the the DT work_zhhbvy463fhkbjyzltzpvocafu 42 86 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 42 87 has have VBZ work_zhhbvy463fhkbjyzltzpvocafu 42 88 been be VBN work_zhhbvy463fhkbjyzltzpvocafu 42 89 ascribed ascribe VBN work_zhhbvy463fhkbjyzltzpvocafu 42 90 to to IN work_zhhbvy463fhkbjyzltzpvocafu 42 91 mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 42 92 in in IN work_zhhbvy463fhkbjyzltzpvocafu 42 93 the the DT work_zhhbvy463fhkbjyzltzpvocafu 42 94 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 42 95 proto proto NN work_zhhbvy463fhkbjyzltzpvocafu 42 96 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 42 97 oncogene oncogene NN work_zhhbvy463fhkbjyzltzpvocafu 42 98 , , , work_zhhbvy463fhkbjyzltzpvocafu 42 99 T T NNP work_zhhbvy463fhkbjyzltzpvocafu 42 100 1,13–16 1,13–16 CD work_zhhbvy463fhkbjyzltzpvocafu 42 101 which which WDT work_zhhbvy463fhkbjyzltzpvocafu 42 102 encodes encode VBZ work_zhhbvy463fhkbjyzltzpvocafu 42 103 a a DT work_zhhbvy463fhkbjyzltzpvocafu 42 104 re- re- JJ work_zhhbvy463fhkbjyzltzpvocafu 42 105 ceptor ceptor NN work_zhhbvy463fhkbjyzltzpvocafu 42 106 tyrosine tyrosine NN work_zhhbvy463fhkbjyzltzpvocafu 42 107 kinase kinase NNP work_zhhbvy463fhkbjyzltzpvocafu 42 108 . . . work_zhhbvy463fhkbjyzltzpvocafu 43 1 However however RB work_zhhbvy463fhkbjyzltzpvocafu 43 2 , , , work_zhhbvy463fhkbjyzltzpvocafu 43 3 the the DT work_zhhbvy463fhkbjyzltzpvocafu 43 4 lack lack NN work_zhhbvy463fhkbjyzltzpvocafu 43 5 of of IN work_zhhbvy463fhkbjyzltzpvocafu 43 6 geno- geno- JJ work_zhhbvy463fhkbjyzltzpvocafu 43 7 type type NN work_zhhbvy463fhkbjyzltzpvocafu 43 8 – – : work_zhhbvy463fhkbjyzltzpvocafu 43 9 phenotype phenotype NN work_zhhbvy463fhkbjyzltzpvocafu 43 10 correlations correlation NNS work_zhhbvy463fhkbjyzltzpvocafu 43 11 , , , work_zhhbvy463fhkbjyzltzpvocafu 43 12 the the DT work_zhhbvy463fhkbjyzltzpvocafu 43 13 low low JJ work_zhhbvy463fhkbjyzltzpvocafu 43 14 penetrance penetrance NN work_zhhbvy463fhkbjyzltzpvocafu 43 15 and and CC work_zhhbvy463fhkbjyzltzpvocafu 43 16 the the DT work_zhhbvy463fhkbjyzltzpvocafu 43 17 sex sex NN work_zhhbvy463fhkbjyzltzpvocafu 43 18 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 43 19 dependent dependent JJ work_zhhbvy463fhkbjyzltzpvocafu 43 20 effect effect NN work_zhhbvy463fhkbjyzltzpvocafu 43 21 of of IN work_zhhbvy463fhkbjyzltzpvocafu 43 22 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 43 23 mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 43 24 supported support VBD work_zhhbvy463fhkbjyzltzpvocafu 43 25 the the DT work_zhhbvy463fhkbjyzltzpvocafu 43 26 existence existence NN work_zhhbvy463fhkbjyzltzpvocafu 43 27 of of IN work_zhhbvy463fhkbjyzltzpvocafu 43 28 one one CD work_zhhbvy463fhkbjyzltzpvocafu 43 29 or or CC work_zhhbvy463fhkbjyzltzpvocafu 43 30 more more JJR work_zhhbvy463fhkbjyzltzpvocafu 43 31 modifier modifier NN work_zhhbvy463fhkbjyzltzpvocafu 43 32 gene(s gene(s NNP work_zhhbvy463fhkbjyzltzpvocafu 43 33 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 43 34 in in IN work_zhhbvy463fhkbjyzltzpvocafu 43 35 familial familial JJ work_zhhbvy463fhkbjyzltzpvocafu 43 36 HSCR.7,17 HSCR.7,17 NNP work_zhhbvy463fhkbjyzltzpvocafu 43 37 Puffenberger Puffenberger NNP work_zhhbvy463fhkbjyzltzpvocafu 43 38 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 43 39 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 43 40 reported report VBD work_zhhbvy463fhkbjyzltzpvocafu 43 41 evidence evidence NN work_zhhbvy463fhkbjyzltzpvocafu 43 42 that that IN work_zhhbvy463fhkbjyzltzpvocafu 43 43 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 43 44 type type NN work_zhhbvy463fhkbjyzltzpvocafu 43 45 2 2 CD work_zhhbvy463fhkbjyzltzpvocafu 43 46 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 43 47 HSCR2 hscr2 NN work_zhhbvy463fhkbjyzltzpvocafu 43 48 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 43 49 OMIM OMIM NNP work_zhhbvy463fhkbjyzltzpvocafu 43 50 600155 600155 CD work_zhhbvy463fhkbjyzltzpvocafu 43 51 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 43 52 , , , work_zhhbvy463fhkbjyzltzpvocafu 43 53 an an DT work_zhhbvy463fhkbjyzltzpvocafu 43 54 apparently apparently RB work_zhhbvy463fhkbjyzltzpvocafu 43 55 multigenic multigenic JJ work_zhhbvy463fhkbjyzltzpvocafu 43 56 dis- dis- IN work_zhhbvy463fhkbjyzltzpvocafu 43 57 order order NN work_zhhbvy463fhkbjyzltzpvocafu 43 58 , , , work_zhhbvy463fhkbjyzltzpvocafu 43 59 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 43 60 due due JJ work_zhhbvy463fhkbjyzltzpvocafu 43 61 to to IN work_zhhbvy463fhkbjyzltzpvocafu 43 62 mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 43 63 in in IN work_zhhbvy463fhkbjyzltzpvocafu 43 64 EDNRB.4 EDNRB.4 NNP work_zhhbvy463fhkbjyzltzpvocafu 43 65 Endothelin Endothelin NNP work_zhhbvy463fhkbjyzltzpvocafu 43 66 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 43 67 EDN EDN NNP work_zhhbvy463fhkbjyzltzpvocafu 43 68 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 43 69 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 43 70 a a DT work_zhhbvy463fhkbjyzltzpvocafu 43 71 potent potent JJ work_zhhbvy463fhkbjyzltzpvocafu 43 72 vasoactive vasoactive JJ work_zhhbvy463fhkbjyzltzpvocafu 43 73 pep- pep- NN work_zhhbvy463fhkbjyzltzpvocafu 43 74 tide tide NN work_zhhbvy463fhkbjyzltzpvocafu 43 75 , , , work_zhhbvy463fhkbjyzltzpvocafu 43 76 which which WDT work_zhhbvy463fhkbjyzltzpvocafu 43 77 can can MD work_zhhbvy463fhkbjyzltzpvocafu 43 78 induce induce VB work_zhhbvy463fhkbjyzltzpvocafu 43 79 a a DT work_zhhbvy463fhkbjyzltzpvocafu 43 80 wide wide JJ work_zhhbvy463fhkbjyzltzpvocafu 43 81 range range NN work_zhhbvy463fhkbjyzltzpvocafu 43 82 of of IN work_zhhbvy463fhkbjyzltzpvocafu 43 83 cellular cellular JJ work_zhhbvy463fhkbjyzltzpvocafu 43 84 and and CC work_zhhbvy463fhkbjyzltzpvocafu 43 85 physiologic physiologic JJ work_zhhbvy463fhkbjyzltzpvocafu 43 86 responses.18 responses.18 NNP work_zhhbvy463fhkbjyzltzpvocafu 43 87 In in IN work_zhhbvy463fhkbjyzltzpvocafu 43 88 mammalian mammalian JJ work_zhhbvy463fhkbjyzltzpvocafu 43 89 cells cell NNS work_zhhbvy463fhkbjyzltzpvocafu 43 90 , , , work_zhhbvy463fhkbjyzltzpvocafu 43 91 there there EX work_zhhbvy463fhkbjyzltzpvocafu 43 92 are be VBP work_zhhbvy463fhkbjyzltzpvocafu 43 93 at at RB work_zhhbvy463fhkbjyzltzpvocafu 43 94 least least RBS work_zhhbvy463fhkbjyzltzpvocafu 43 95 two two CD work_zhhbvy463fhkbjyzltzpvocafu 43 96 EDN EDN NNP work_zhhbvy463fhkbjyzltzpvocafu 43 97 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 43 98 subtypes subtype NNS work_zhhbvy463fhkbjyzltzpvocafu 43 99 , , , work_zhhbvy463fhkbjyzltzpvocafu 43 100 EDNRA EDNRA NNP work_zhhbvy463fhkbjyzltzpvocafu 43 101 and and CC work_zhhbvy463fhkbjyzltzpvocafu 43 102 EDNRB,19 EDNRB,19 NNP work_zhhbvy463fhkbjyzltzpvocafu 43 103 both both DT work_zhhbvy463fhkbjyzltzpvocafu 43 104 of of IN work_zhhbvy463fhkbjyzltzpvocafu 43 105 which which WDT work_zhhbvy463fhkbjyzltzpvocafu 43 106 belong belong VBP work_zhhbvy463fhkbjyzltzpvocafu 43 107 to to IN work_zhhbvy463fhkbjyzltzpvocafu 43 108 the the DT work_zhhbvy463fhkbjyzltzpvocafu 43 109 superfamily superfamily NN work_zhhbvy463fhkbjyzltzpvocafu 43 110 of of IN work_zhhbvy463fhkbjyzltzpvocafu 43 111 rhodopsin rhodopsin NN work_zhhbvy463fhkbjyzltzpvocafu 43 112 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 43 113 like like JJ work_zhhbvy463fhkbjyzltzpvocafu 43 114 G g NN work_zhhbvy463fhkbjyzltzpvocafu 43 115 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 43 116 protein- protein- JJ work_zhhbvy463fhkbjyzltzpvocafu 43 117 coupled couple VBN work_zhhbvy463fhkbjyzltzpvocafu 43 118 receptors receptor NNS work_zhhbvy463fhkbjyzltzpvocafu 43 119 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 43 120 GPCRs)20 GPCRs)20 NNP work_zhhbvy463fhkbjyzltzpvocafu 43 121 that that WDT work_zhhbvy463fhkbjyzltzpvocafu 43 122 contain contain VBP work_zhhbvy463fhkbjyzltzpvocafu 43 123 seven seven CD work_zhhbvy463fhkbjyzltzpvocafu 43 124 Table table NN work_zhhbvy463fhkbjyzltzpvocafu 43 125 2 2 CD work_zhhbvy463fhkbjyzltzpvocafu 43 126 . . . work_zhhbvy463fhkbjyzltzpvocafu 44 1 PCR PCR NNP work_zhhbvy463fhkbjyzltzpvocafu 44 2 primers primer NNS work_zhhbvy463fhkbjyzltzpvocafu 44 3 used use VBN work_zhhbvy463fhkbjyzltzpvocafu 44 4 for for IN work_zhhbvy463fhkbjyzltzpvocafu 44 5 the the DT work_zhhbvy463fhkbjyzltzpvocafu 44 6 amplification amplification NN work_zhhbvy463fhkbjyzltzpvocafu 44 7 of of IN work_zhhbvy463fhkbjyzltzpvocafu 44 8 the the DT work_zhhbvy463fhkbjyzltzpvocafu 44 9 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 44 10 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 44 11 from from IN work_zhhbvy463fhkbjyzltzpvocafu 44 12 genomic genomic JJ work_zhhbvy463fhkbjyzltzpvocafu 44 13 DNA DNA NNP work_zhhbvy463fhkbjyzltzpvocafu 44 14 Exon Exon NNP work_zhhbvy463fhkbjyzltzpvocafu 44 15 Forward Forward NNP work_zhhbvy463fhkbjyzltzpvocafu 44 16 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 44 17 5 5 CD work_zhhbvy463fhkbjyzltzpvocafu 44 18 ’ ’ CD work_zhhbvy463fhkbjyzltzpvocafu 44 19 ➔ ➔ CD work_zhhbvy463fhkbjyzltzpvocafu 44 20 3 3 CD work_zhhbvy463fhkbjyzltzpvocafu 44 21 ’ ' '' work_zhhbvy463fhkbjyzltzpvocafu 44 22 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 44 23 Backward Backward NNP work_zhhbvy463fhkbjyzltzpvocafu 44 24 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 44 25 5 5 CD work_zhhbvy463fhkbjyzltzpvocafu 44 26 ’ ’ CD work_zhhbvy463fhkbjyzltzpvocafu 44 27 ➔ ➔ CD work_zhhbvy463fhkbjyzltzpvocafu 44 28 3 3 CD work_zhhbvy463fhkbjyzltzpvocafu 44 29 ’ ' '' work_zhhbvy463fhkbjyzltzpvocafu 44 30 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 44 31 Product product NN work_zhhbvy463fhkbjyzltzpvocafu 44 32 size size NN work_zhhbvy463fhkbjyzltzpvocafu 44 33 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 44 34 bp bp NN work_zhhbvy463fhkbjyzltzpvocafu 44 35 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 44 36 AT AT NNP work_zhhbvy463fhkbjyzltzpvocafu 44 37 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 44 38 ° ° NNP work_zhhbvy463fhkbjyzltzpvocafu 44 39 C C NNP work_zhhbvy463fhkbjyzltzpvocafu 44 40 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 44 41 1 1 CD work_zhhbvy463fhkbjyzltzpvocafu 44 42 CTCTGCTTGTCTCTAGGCTC CTCTGCTTGTCTCTAGGCTC NNP work_zhhbvy463fhkbjyzltzpvocafu 44 43 GATTCAGTAGGTCTGGGGTG GATTCAGTAGGTCTGGGGTG NNP work_zhhbvy463fhkbjyzltzpvocafu 44 44 881 881 CD work_zhhbvy463fhkbjyzltzpvocafu 44 45 55 55 CD work_zhhbvy463fhkbjyzltzpvocafu 44 46 2,3 2,3 CD work_zhhbvy463fhkbjyzltzpvocafu 44 47 GTGATACAATTCAGAGGGCA GTGATACAATTCAGAGGGCA NNP work_zhhbvy463fhkbjyzltzpvocafu 44 48 CACTGAGATCAAGGGGATTC cactgagatcaaggggattc RB work_zhhbvy463fhkbjyzltzpvocafu 44 49 734 734 CD work_zhhbvy463fhkbjyzltzpvocafu 44 50 50 50 CD work_zhhbvy463fhkbjyzltzpvocafu 44 51 4 4 CD work_zhhbvy463fhkbjyzltzpvocafu 44 52 CAGTAAGTGTGGCCTGAAAG cagtaagtgtggcctgaaag NN work_zhhbvy463fhkbjyzltzpvocafu 44 53 GTGAAGTGGAACCGAAGTGA GTGAAGTGGAACCGAAGTGA NNP work_zhhbvy463fhkbjyzltzpvocafu 44 54 562 562 CD work_zhhbvy463fhkbjyzltzpvocafu 44 55 50 50 CD work_zhhbvy463fhkbjyzltzpvocafu 44 56 5 5 CD work_zhhbvy463fhkbjyzltzpvocafu 44 57 GATCTAGGGAGAATCAGAAC GATCTAGGGAGAATCAGAAC NNS work_zhhbvy463fhkbjyzltzpvocafu 44 58 GAAGTACTGAAGCTGGCTGA GAAGTACTGAAGCTGGCTGA NNP work_zhhbvy463fhkbjyzltzpvocafu 44 59 643 643 CD work_zhhbvy463fhkbjyzltzpvocafu 44 60 50 50 CD work_zhhbvy463fhkbjyzltzpvocafu 44 61 6 6 CD work_zhhbvy463fhkbjyzltzpvocafu 44 62 GCACAGAAGCTACAATGACT GCACAGAAGCTACAATGACT NNP work_zhhbvy463fhkbjyzltzpvocafu 44 63 CTACCAAAAACAGGGAACAG ctaccaaaaacagggaacag NN work_zhhbvy463fhkbjyzltzpvocafu 44 64 530 530 CD work_zhhbvy463fhkbjyzltzpvocafu 44 65 50 50 CD work_zhhbvy463fhkbjyzltzpvocafu 44 66 7 7 CD work_zhhbvy463fhkbjyzltzpvocafu 44 67 CAAAGAAAGTCAGAACCCTG caaagaaagtcagaaccctg NN work_zhhbvy463fhkbjyzltzpvocafu 44 68 TCCATGCCGTAAACAGCTCA tccatgccgtaaacagctca DT work_zhhbvy463fhkbjyzltzpvocafu 44 69 407 407 CD work_zhhbvy463fhkbjyzltzpvocafu 44 70 50 50 CD work_zhhbvy463fhkbjyzltzpvocafu 44 71 AT at IN work_zhhbvy463fhkbjyzltzpvocafu 44 72 = = SYM work_zhhbvy463fhkbjyzltzpvocafu 44 73 annealing anneal VBG work_zhhbvy463fhkbjyzltzpvocafu 44 74 temperature temperature NN work_zhhbvy463fhkbjyzltzpvocafu 44 75 . . . work_zhhbvy463fhkbjyzltzpvocafu 45 1 Figure figure NN work_zhhbvy463fhkbjyzltzpvocafu 45 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 46 1 Automated Automated NNP work_zhhbvy463fhkbjyzltzpvocafu 46 2 DNA DNA NNP work_zhhbvy463fhkbjyzltzpvocafu 46 3 sequenc- sequenc- NN work_zhhbvy463fhkbjyzltzpvocafu 46 4 ing ing NN work_zhhbvy463fhkbjyzltzpvocafu 46 5 of of IN work_zhhbvy463fhkbjyzltzpvocafu 46 6 the the DT work_zhhbvy463fhkbjyzltzpvocafu 46 7 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 46 8 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 46 9 revealed reveal VBD work_zhhbvy463fhkbjyzltzpvocafu 46 10 a a DT work_zhhbvy463fhkbjyzltzpvocafu 46 11 T t NN work_zhhbvy463fhkbjyzltzpvocafu 46 12 to to IN work_zhhbvy463fhkbjyzltzpvocafu 46 13 C c NN work_zhhbvy463fhkbjyzltzpvocafu 46 14 transition transition NN work_zhhbvy463fhkbjyzltzpvocafu 46 15 : : : work_zhhbvy463fhkbjyzltzpvocafu 46 16 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 46 17 A a DT work_zhhbvy463fhkbjyzltzpvocafu 46 18 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 46 19 sequence sequence NN work_zhhbvy463fhkbjyzltzpvocafu 46 20 from from IN work_zhhbvy463fhkbjyzltzpvocafu 46 21 the the DT work_zhhbvy463fhkbjyzltzpvocafu 46 22 proband proband NN work_zhhbvy463fhkbjyzltzpvocafu 46 23 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 46 24 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 46 25 B b NN work_zhhbvy463fhkbjyzltzpvocafu 46 26 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 46 27 sequence sequence NN work_zhhbvy463fhkbjyzltzpvocafu 46 28 from from IN work_zhhbvy463fhkbjyzltzpvocafu 46 29 a a DT work_zhhbvy463fhkbjyzltzpvocafu 46 30 normal normal JJ work_zhhbvy463fhkbjyzltzpvocafu 46 31 control control NN work_zhhbvy463fhkbjyzltzpvocafu 46 32 . . . work_zhhbvy463fhkbjyzltzpvocafu 47 1 BB BB NNP work_zhhbvy463fhkbjyzltzpvocafu 47 2 A a DT work_zhhbvy463fhkbjyzltzpvocafu 47 3 352 352 CD work_zhhbvy463fhkbjyzltzpvocafu 47 4 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 47 5 Formos Formos NNP work_zhhbvy463fhkbjyzltzpvocafu 47 6 Med Med NNP work_zhhbvy463fhkbjyzltzpvocafu 47 7 Assoc Assoc NNP work_zhhbvy463fhkbjyzltzpvocafu 47 8 | | CD work_zhhbvy463fhkbjyzltzpvocafu 47 9 2006 2006 CD work_zhhbvy463fhkbjyzltzpvocafu 47 10 • • NNP work_zhhbvy463fhkbjyzltzpvocafu 47 11 Vol Vol NNP work_zhhbvy463fhkbjyzltzpvocafu 47 12 105 105 CD work_zhhbvy463fhkbjyzltzpvocafu 47 13 • • NNP work_zhhbvy463fhkbjyzltzpvocafu 47 14 No no DT work_zhhbvy463fhkbjyzltzpvocafu 47 15 4 4 CD work_zhhbvy463fhkbjyzltzpvocafu 47 16 W.C. W.C. NNP work_zhhbvy463fhkbjyzltzpvocafu 47 17 Chen Chen NNP work_zhhbvy463fhkbjyzltzpvocafu 47 18 , , , work_zhhbvy463fhkbjyzltzpvocafu 47 19 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 47 20 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 47 21 transmembrane transmembrane NNP work_zhhbvy463fhkbjyzltzpvocafu 47 22 domains domains NNP work_zhhbvy463fhkbjyzltzpvocafu 47 23 . . . work_zhhbvy463fhkbjyzltzpvocafu 48 1 The the DT work_zhhbvy463fhkbjyzltzpvocafu 48 2 extracellular extracellular JJ work_zhhbvy463fhkbjyzltzpvocafu 48 3 and and CC work_zhhbvy463fhkbjyzltzpvocafu 48 4 transmembrane transmembrane JJ work_zhhbvy463fhkbjyzltzpvocafu 48 5 domains domain NNS work_zhhbvy463fhkbjyzltzpvocafu 48 6 of of IN work_zhhbvy463fhkbjyzltzpvocafu 48 7 GPCRs gpcr NNS work_zhhbvy463fhkbjyzltzpvocafu 48 8 are be VBP work_zhhbvy463fhkbjyzltzpvocafu 48 9 involved involve VBN work_zhhbvy463fhkbjyzltzpvocafu 48 10 in in IN work_zhhbvy463fhkbjyzltzpvocafu 48 11 ligand ligand NN work_zhhbvy463fhkbjyzltzpvocafu 48 12 binding binding NN work_zhhbvy463fhkbjyzltzpvocafu 48 13 , , , work_zhhbvy463fhkbjyzltzpvocafu 48 14 whereas whereas IN work_zhhbvy463fhkbjyzltzpvocafu 48 15 the the DT work_zhhbvy463fhkbjyzltzpvocafu 48 16 intracellular intracellular JJ work_zhhbvy463fhkbjyzltzpvocafu 48 17 do- do- JJ work_zhhbvy463fhkbjyzltzpvocafu 48 18 mains main NNS work_zhhbvy463fhkbjyzltzpvocafu 48 19 are be VBP work_zhhbvy463fhkbjyzltzpvocafu 48 20 involved involve VBN work_zhhbvy463fhkbjyzltzpvocafu 48 21 in in IN work_zhhbvy463fhkbjyzltzpvocafu 48 22 G g NN work_zhhbvy463fhkbjyzltzpvocafu 48 23 protein protein NN work_zhhbvy463fhkbjyzltzpvocafu 48 24 coupling coupling NN work_zhhbvy463fhkbjyzltzpvocafu 48 25 and and CC work_zhhbvy463fhkbjyzltzpvocafu 48 26 subsequent subsequent JJ work_zhhbvy463fhkbjyzltzpvocafu 48 27 effector effector NN work_zhhbvy463fhkbjyzltzpvocafu 48 28 regulation regulation NN work_zhhbvy463fhkbjyzltzpvocafu 48 29 . . . work_zhhbvy463fhkbjyzltzpvocafu 49 1 To to TO work_zhhbvy463fhkbjyzltzpvocafu 49 2 determine determine VB work_zhhbvy463fhkbjyzltzpvocafu 49 3 when when WRB work_zhhbvy463fhkbjyzltzpvocafu 49 4 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 49 5 signaling signal VBG work_zhhbvy463fhkbjyzltzpvocafu 49 6 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 49 7 required require VBN work_zhhbvy463fhkbjyzltzpvocafu 49 8 during during IN work_zhhbvy463fhkbjyzltzpvocafu 49 9 em- em- NNP work_zhhbvy463fhkbjyzltzpvocafu 49 10 bryogenesis bryogenesis NN work_zhhbvy463fhkbjyzltzpvocafu 49 11 , , , work_zhhbvy463fhkbjyzltzpvocafu 49 12 Shin Shin NNP work_zhhbvy463fhkbjyzltzpvocafu 49 13 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 49 14 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 49 15 determined determine VBD work_zhhbvy463fhkbjyzltzpvocafu 49 16 that that IN work_zhhbvy463fhkbjyzltzpvocafu 49 17 Ednrb Ednrb NNP work_zhhbvy463fhkbjyzltzpvocafu 49 18 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 49 19 required require VBN work_zhhbvy463fhkbjyzltzpvocafu 49 20 during during IN work_zhhbvy463fhkbjyzltzpvocafu 49 21 a a DT work_zhhbvy463fhkbjyzltzpvocafu 49 22 restricted restricted JJ work_zhhbvy463fhkbjyzltzpvocafu 49 23 period period NN work_zhhbvy463fhkbjyzltzpvocafu 49 24 of of IN work_zhhbvy463fhkbjyzltzpvocafu 49 25 neural neural JJ work_zhhbvy463fhkbjyzltzpvocafu 49 26 crest crest NN work_zhhbvy463fhkbjyzltzpvocafu 49 27 development development NN work_zhhbvy463fhkbjyzltzpvocafu 49 28 between between IN work_zhhbvy463fhkbjyzltzpvocafu 49 29 embryonic embryonic JJ work_zhhbvy463fhkbjyzltzpvocafu 49 30 days day NNS work_zhhbvy463fhkbjyzltzpvocafu 49 31 10 10 CD work_zhhbvy463fhkbjyzltzpvocafu 49 32 and and CC work_zhhbvy463fhkbjyzltzpvocafu 49 33 12.5.21 12.5.21 NNP work_zhhbvy463fhkbjyzltzpvocafu 49 34 They -PRON- PRP work_zhhbvy463fhkbjyzltzpvocafu 49 35 concluded conclude VBD work_zhhbvy463fhkbjyzltzpvocafu 49 36 that that IN work_zhhbvy463fhkbjyzltzpvocafu 49 37 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 49 38 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 49 39 required require VBN work_zhhbvy463fhkbjyzltzpvocafu 49 40 for for IN work_zhhbvy463fhkbjyzltzpvocafu 49 41 the the DT work_zhhbvy463fhkbjyzltzpvocafu 49 42 migration migration NN work_zhhbvy463fhkbjyzltzpvocafu 49 43 of of IN work_zhhbvy463fhkbjyzltzpvocafu 49 44 both both DT work_zhhbvy463fhkbjyzltzpvocafu 49 45 melanoblasts melanoblast NNS work_zhhbvy463fhkbjyzltzpvocafu 49 46 and and CC work_zhhbvy463fhkbjyzltzpvocafu 49 47 enteric enteric JJ work_zhhbvy463fhkbjyzltzpvocafu 49 48 neuroblasts neuroblast NNS work_zhhbvy463fhkbjyzltzpvocafu 49 49 . . . work_zhhbvy463fhkbjyzltzpvocafu 50 1 Arai Arai NNP work_zhhbvy463fhkbjyzltzpvocafu 50 2 et et FW work_zhhbvy463fhkbjyzltzpvocafu 50 3 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 50 4 demonstrated demonstrate VBD work_zhhbvy463fhkbjyzltzpvocafu 50 5 that that IN work_zhhbvy463fhkbjyzltzpvocafu 50 6 the the DT work_zhhbvy463fhkbjyzltzpvocafu 50 7 human human JJ work_zhhbvy463fhkbjyzltzpvocafu 50 8 genome genome NN work_zhhbvy463fhkbjyzltzpvocafu 50 9 contains contain VBZ work_zhhbvy463fhkbjyzltzpvocafu 50 10 a a DT work_zhhbvy463fhkbjyzltzpvocafu 50 11 single single JJ work_zhhbvy463fhkbjyzltzpvocafu 50 12 copy copy NN work_zhhbvy463fhkbjyzltzpvocafu 50 13 of of IN work_zhhbvy463fhkbjyzltzpvocafu 50 14 the the DT work_zhhbvy463fhkbjyzltzpvocafu 50 15 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 50 16 gene,22 gene,22 NNP work_zhhbvy463fhkbjyzltzpvocafu 50 17 which which WDT work_zhhbvy463fhkbjyzltzpvocafu 50 18 spans span VBZ work_zhhbvy463fhkbjyzltzpvocafu 50 19 24 24 CD work_zhhbvy463fhkbjyzltzpvocafu 50 20 kb kb NNS work_zhhbvy463fhkbjyzltzpvocafu 50 21 and and CC work_zhhbvy463fhkbjyzltzpvocafu 50 22 comprises comprise VBZ work_zhhbvy463fhkbjyzltzpvocafu 50 23 7 7 CD work_zhhbvy463fhkbjyzltzpvocafu 50 24 exons exon NNS work_zhhbvy463fhkbjyzltzpvocafu 50 25 and and CC work_zhhbvy463fhkbjyzltzpvocafu 50 26 6 6 CD work_zhhbvy463fhkbjyzltzpvocafu 50 27 introns intron NNS work_zhhbvy463fhkbjyzltzpvocafu 50 28 that that WDT work_zhhbvy463fhkbjyzltzpvocafu 50 29 encode encode VBP work_zhhbvy463fhkbjyzltzpvocafu 50 30 a a DT work_zhhbvy463fhkbjyzltzpvocafu 50 31 442 442 CD work_zhhbvy463fhkbjyzltzpvocafu 50 32 amino amino NN work_zhhbvy463fhkbjyzltzpvocafu 50 33 acid acid NN work_zhhbvy463fhkbjyzltzpvocafu 50 34 protein protein NN work_zhhbvy463fhkbjyzltzpvocafu 50 35 expressed express VBN work_zhhbvy463fhkbjyzltzpvocafu 50 36 in in IN work_zhhbvy463fhkbjyzltzpvocafu 50 37 brain brain NN work_zhhbvy463fhkbjyzltzpvocafu 50 38 , , , work_zhhbvy463fhkbjyzltzpvocafu 50 39 kidney kidney NN work_zhhbvy463fhkbjyzltzpvocafu 50 40 , , , work_zhhbvy463fhkbjyzltzpvocafu 50 41 lung lung NN work_zhhbvy463fhkbjyzltzpvocafu 50 42 , , , work_zhhbvy463fhkbjyzltzpvocafu 50 43 heart heart NN work_zhhbvy463fhkbjyzltzpvocafu 50 44 and and CC work_zhhbvy463fhkbjyzltzpvocafu 50 45 endothelial endothelial JJ work_zhhbvy463fhkbjyzltzpvocafu 50 46 cells.23 cells.23 NNP work_zhhbvy463fhkbjyzltzpvocafu 50 47 Inagaki Inagaki NNP work_zhhbvy463fhkbjyzltzpvocafu 50 48 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 50 49 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 50 50 showed show VBD work_zhhbvy463fhkbjyzltzpvocafu 50 51 that that IN work_zhhbvy463fhkbjyzltzpvocafu 50 52 this this DT work_zhhbvy463fhkbjyzltzpvocafu 50 53 protein protein NN work_zhhbvy463fhkbjyzltzpvocafu 50 54 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 50 55 also also RB work_zhhbvy463fhkbjyzltzpvocafu 50 56 ex- ex- RB work_zhhbvy463fhkbjyzltzpvocafu 50 57 pressed press VBN work_zhhbvy463fhkbjyzltzpvocafu 50 58 in in IN work_zhhbvy463fhkbjyzltzpvocafu 50 59 the the DT work_zhhbvy463fhkbjyzltzpvocafu 50 60 human human JJ work_zhhbvy463fhkbjyzltzpvocafu 50 61 colon colon NN work_zhhbvy463fhkbjyzltzpvocafu 50 62 , , , work_zhhbvy463fhkbjyzltzpvocafu 50 63 particularly particularly RB work_zhhbvy463fhkbjyzltzpvocafu 50 64 in in IN work_zhhbvy463fhkbjyzltzpvocafu 50 65 the the DT work_zhhbvy463fhkbjyzltzpvocafu 50 66 myenteric myenteric NNP work_zhhbvy463fhkbjyzltzpvocafu 50 67 plexus plexus NNP work_zhhbvy463fhkbjyzltzpvocafu 50 68 , , , work_zhhbvy463fhkbjyzltzpvocafu 50 69 mucosal mucosal NN work_zhhbvy463fhkbjyzltzpvocafu 50 70 layer layer NNP work_zhhbvy463fhkbjyzltzpvocafu 50 71 , , , work_zhhbvy463fhkbjyzltzpvocafu 50 72 ganglion ganglion NN work_zhhbvy463fhkbjyzltzpvocafu 50 73 and and CC work_zhhbvy463fhkbjyzltzpvocafu 50 74 blood blood NN work_zhhbvy463fhkbjyzltzpvocafu 50 75 vessels vessel NNS work_zhhbvy463fhkbjyzltzpvocafu 50 76 of of IN work_zhhbvy463fhkbjyzltzpvocafu 50 77 the the DT work_zhhbvy463fhkbjyzltzpvocafu 50 78 submucosa.24 submucosa.24 NNP work_zhhbvy463fhkbjyzltzpvocafu 50 79 Recently recently RB work_zhhbvy463fhkbjyzltzpvocafu 50 80 , , , work_zhhbvy463fhkbjyzltzpvocafu 50 81 muta- muta- JJ work_zhhbvy463fhkbjyzltzpvocafu 50 82 tions tion NNS work_zhhbvy463fhkbjyzltzpvocafu 50 83 in in IN work_zhhbvy463fhkbjyzltzpvocafu 50 84 the the DT work_zhhbvy463fhkbjyzltzpvocafu 50 85 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 50 86 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 50 87 have have VBP work_zhhbvy463fhkbjyzltzpvocafu 50 88 been be VBN work_zhhbvy463fhkbjyzltzpvocafu 50 89 identified identify VBN work_zhhbvy463fhkbjyzltzpvocafu 50 90 in in IN work_zhhbvy463fhkbjyzltzpvocafu 50 91 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 50 92 patients,8 patients,8 NNP work_zhhbvy463fhkbjyzltzpvocafu 50 93 including include VBG work_zhhbvy463fhkbjyzltzpvocafu 50 94 deletion deletion NN work_zhhbvy463fhkbjyzltzpvocafu 50 95 / / SYM work_zhhbvy463fhkbjyzltzpvocafu 50 96 insertion insertion NN work_zhhbvy463fhkbjyzltzpvocafu 50 97 mutations,25,26 mutations,25,26 NNP work_zhhbvy463fhkbjyzltzpvocafu 50 98 non non JJ work_zhhbvy463fhkbjyzltzpvocafu 50 99 - - JJ work_zhhbvy463fhkbjyzltzpvocafu 50 100 sense sense NN work_zhhbvy463fhkbjyzltzpvocafu 50 101 mutations,26–28 mutations,26–28 RB work_zhhbvy463fhkbjyzltzpvocafu 50 102 splicing splice VBG work_zhhbvy463fhkbjyzltzpvocafu 50 103 mutations29 mutations29 NNP work_zhhbvy463fhkbjyzltzpvocafu 50 104 and and CC work_zhhbvy463fhkbjyzltzpvocafu 50 105 several several JJ work_zhhbvy463fhkbjyzltzpvocafu 50 106 missense missense NN work_zhhbvy463fhkbjyzltzpvocafu 50 107 mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 50 108 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 50 109 Table table NN work_zhhbvy463fhkbjyzltzpvocafu 50 110 3).4,5,9,25,30–35 3).4,5,9,25,30–35 CD work_zhhbvy463fhkbjyzltzpvocafu 50 111 The the DT work_zhhbvy463fhkbjyzltzpvocafu 50 112 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 50 113 was be VBD work_zhhbvy463fhkbjyzltzpvocafu 50 114 dosage dosage NN work_zhhbvy463fhkbjyzltzpvocafu 50 115 sensitive sensitive JJ work_zhhbvy463fhkbjyzltzpvocafu 50 116 in in IN work_zhhbvy463fhkbjyzltzpvocafu 50 117 that that IN work_zhhbvy463fhkbjyzltzpvocafu 50 118 homozygotes homozygote NNS work_zhhbvy463fhkbjyzltzpvocafu 50 119 and and CC work_zhhbvy463fhkbjyzltzpvocafu 50 120 heterozygotes heterozygote NNS work_zhhbvy463fhkbjyzltzpvocafu 50 121 had have VBD work_zhhbvy463fhkbjyzltzpvocafu 50 122 a a DT work_zhhbvy463fhkbjyzltzpvocafu 50 123 74 74 CD work_zhhbvy463fhkbjyzltzpvocafu 50 124 % % NN work_zhhbvy463fhkbjyzltzpvocafu 50 125 and and CC work_zhhbvy463fhkbjyzltzpvocafu 50 126 a a DT work_zhhbvy463fhkbjyzltzpvocafu 50 127 21 21 CD work_zhhbvy463fhkbjyzltzpvocafu 50 128 % % NN work_zhhbvy463fhkbjyzltzpvocafu 50 129 risk risk NN work_zhhbvy463fhkbjyzltzpvocafu 50 130 , , , work_zhhbvy463fhkbjyzltzpvocafu 50 131 respectively respectively RB work_zhhbvy463fhkbjyzltzpvocafu 50 132 , , , work_zhhbvy463fhkbjyzltzpvocafu 50 133 of of IN work_zhhbvy463fhkbjyzltzpvocafu 50 134 developing develop VBG work_zhhbvy463fhkbjyzltzpvocafu 50 135 HSCR.4 hscr.4 JJ work_zhhbvy463fhkbjyzltzpvocafu 50 136 Other other JJ work_zhhbvy463fhkbjyzltzpvocafu 50 137 analyses analysis NNS work_zhhbvy463fhkbjyzltzpvocafu 50 138 of of IN work_zhhbvy463fhkbjyzltzpvocafu 50 139 patients patient NNS work_zhhbvy463fhkbjyzltzpvocafu 50 140 in in IN work_zhhbvy463fhkbjyzltzpvocafu 50 141 the the DT work_zhhbvy463fhkbjyzltzpvocafu 50 142 extended extended JJ work_zhhbvy463fhkbjyzltzpvocafu 50 143 Mennonite Mennonite NNP work_zhhbvy463fhkbjyzltzpvocafu 50 144 pedigree pedigree NN work_zhhbvy463fhkbjyzltzpvocafu 50 145 showed show VBD work_zhhbvy463fhkbjyzltzpvocafu 50 146 that that IN work_zhhbvy463fhkbjyzltzpvocafu 50 147 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 50 148 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 50 149 a a DT work_zhhbvy463fhkbjyzltzpvocafu 50 150 multigenic multigenic JJ work_zhhbvy463fhkbjyzltzpvocafu 50 151 disorder disorder NN work_zhhbvy463fhkbjyzltzpvocafu 50 152 . . . work_zhhbvy463fhkbjyzltzpvocafu 51 1 For for IN work_zhhbvy463fhkbjyzltzpvocafu 51 2 all all DT work_zhhbvy463fhkbjyzltzpvocafu 51 3 clinical clinical JJ work_zhhbvy463fhkbjyzltzpvocafu 51 4 forms form NNS work_zhhbvy463fhkbjyzltzpvocafu 51 5 of of IN work_zhhbvy463fhkbjyzltzpvocafu 51 6 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 51 7 , , , work_zhhbvy463fhkbjyzltzpvocafu 51 8 there there EX work_zhhbvy463fhkbjyzltzpvocafu 51 9 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 51 10 a a DT work_zhhbvy463fhkbjyzltzpvocafu 51 11 greater great JJR work_zhhbvy463fhkbjyzltzpvocafu 51 12 incidence incidence NN work_zhhbvy463fhkbjyzltzpvocafu 51 13 of of IN work_zhhbvy463fhkbjyzltzpvocafu 51 14 megacolon megacolon NN work_zhhbvy463fhkbjyzltzpvocafu 51 15 in in IN work_zhhbvy463fhkbjyzltzpvocafu 51 16 males male NNS work_zhhbvy463fhkbjyzltzpvocafu 51 17 than than IN work_zhhbvy463fhkbjyzltzpvocafu 51 18 in in IN work_zhhbvy463fhkbjyzltzpvocafu 51 19 females female NNS work_zhhbvy463fhkbjyzltzpvocafu 51 20 , , , work_zhhbvy463fhkbjyzltzpvocafu 51 21 and and CC work_zhhbvy463fhkbjyzltzpvocafu 51 22 the the DT work_zhhbvy463fhkbjyzltzpvocafu 51 23 same same JJ work_zhhbvy463fhkbjyzltzpvocafu 51 24 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 51 25 true true JJ work_zhhbvy463fhkbjyzltzpvocafu 51 26 for for IN work_zhhbvy463fhkbjyzltzpvocafu 51 27 the the DT work_zhhbvy463fhkbjyzltzpvocafu 51 28 spe- spe- NN work_zhhbvy463fhkbjyzltzpvocafu 51 29 cific cific JJ work_zhhbvy463fhkbjyzltzpvocafu 51 30 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 51 31 mutation.12 mutation.12 NNP work_zhhbvy463fhkbjyzltzpvocafu 51 32 The the DT work_zhhbvy463fhkbjyzltzpvocafu 51 33 C90R C90R NNP work_zhhbvy463fhkbjyzltzpvocafu 51 34 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 51 35 seems seem VBZ work_zhhbvy463fhkbjyzltzpvocafu 51 36 to to TO work_zhhbvy463fhkbjyzltzpvocafu 51 37 be be VB work_zhhbvy463fhkbjyzltzpvocafu 51 38 significant significant JJ work_zhhbvy463fhkbjyzltzpvocafu 51 39 in in IN work_zhhbvy463fhkbjyzltzpvocafu 51 40 the the DT work_zhhbvy463fhkbjyzltzpvocafu 51 41 pathogenesis pathogenesis NN work_zhhbvy463fhkbjyzltzpvocafu 51 42 of of IN work_zhhbvy463fhkbjyzltzpvocafu 51 43 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 51 44 for for IN work_zhhbvy463fhkbjyzltzpvocafu 51 45 several several JJ work_zhhbvy463fhkbjyzltzpvocafu 51 46 reasons reason NNS work_zhhbvy463fhkbjyzltzpvocafu 51 47 : : : work_zhhbvy463fhkbjyzltzpvocafu 51 48 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 51 49 1 1 LS work_zhhbvy463fhkbjyzltzpvocafu 51 50 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 51 51 it -PRON- PRP work_zhhbvy463fhkbjyzltzpvocafu 51 52 was be VBD work_zhhbvy463fhkbjyzltzpvocafu 51 53 absent absent JJ work_zhhbvy463fhkbjyzltzpvocafu 51 54 in in IN work_zhhbvy463fhkbjyzltzpvocafu 51 55 100 100 CD work_zhhbvy463fhkbjyzltzpvocafu 51 56 normal normal JJ work_zhhbvy463fhkbjyzltzpvocafu 51 57 controls control NNS work_zhhbvy463fhkbjyzltzpvocafu 51 58 , , , work_zhhbvy463fhkbjyzltzpvocafu 51 59 making make VBG work_zhhbvy463fhkbjyzltzpvocafu 51 60 the the DT work_zhhbvy463fhkbjyzltzpvocafu 51 61 hypothesis hypothesis NN work_zhhbvy463fhkbjyzltzpvocafu 51 62 of of IN work_zhhbvy463fhkbjyzltzpvocafu 51 63 a a DT work_zhhbvy463fhkbjyzltzpvocafu 51 64 coincidental coincidental JJ work_zhhbvy463fhkbjyzltzpvocafu 51 65 polymorphism polymorphism NN work_zhhbvy463fhkbjyzltzpvocafu 51 66 very very RB work_zhhbvy463fhkbjyzltzpvocafu 51 67 unlikely unlikely JJ work_zhhbvy463fhkbjyzltzpvocafu 51 68 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 51 69 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 51 70 2 2 LS work_zhhbvy463fhkbjyzltzpvocafu 51 71 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 51 72 it -PRON- PRP work_zhhbvy463fhkbjyzltzpvocafu 51 73 led lead VBD work_zhhbvy463fhkbjyzltzpvocafu 51 74 to to IN work_zhhbvy463fhkbjyzltzpvocafu 51 75 substitution substitution NN work_zhhbvy463fhkbjyzltzpvocafu 51 76 of of IN work_zhhbvy463fhkbjyzltzpvocafu 51 77 a a DT work_zhhbvy463fhkbjyzltzpvocafu 51 78 hydrophilic hydrophilic JJ work_zhhbvy463fhkbjyzltzpvocafu 51 79 amino amino NN work_zhhbvy463fhkbjyzltzpvocafu 51 80 acid acid NN work_zhhbvy463fhkbjyzltzpvocafu 51 81 with with IN work_zhhbvy463fhkbjyzltzpvocafu 51 82 a a DT work_zhhbvy463fhkbjyzltzpvocafu 51 83 polar polar JJ work_zhhbvy463fhkbjyzltzpvocafu 51 84 side side NN work_zhhbvy463fhkbjyzltzpvocafu 51 85 chain chain NN work_zhhbvy463fhkbjyzltzpvocafu 51 86 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 51 87 cysteine cysteine NN work_zhhbvy463fhkbjyzltzpvocafu 51 88 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 51 89 by by IN work_zhhbvy463fhkbjyzltzpvocafu 51 90 Table table NN work_zhhbvy463fhkbjyzltzpvocafu 51 91 3 3 CD work_zhhbvy463fhkbjyzltzpvocafu 51 92 . . . work_zhhbvy463fhkbjyzltzpvocafu 52 1 Endothelin Endothelin NNP work_zhhbvy463fhkbjyzltzpvocafu 52 2 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 52 3 B B NNP work_zhhbvy463fhkbjyzltzpvocafu 52 4 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 52 5 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 52 6 mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 52 7 in in IN work_zhhbvy463fhkbjyzltzpvocafu 52 8 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 52 9 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 52 10 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 11 HSCR)/Waardenburg HSCR)/Waardenburg NNP work_zhhbvy463fhkbjyzltzpvocafu 52 12 syndrome syndrome NN work_zhhbvy463fhkbjyzltzpvocafu 52 13 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 14 WS WS NNP work_zhhbvy463fhkbjyzltzpvocafu 52 15 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 52 16 Mutation Mutation NNP work_zhhbvy463fhkbjyzltzpvocafu 52 17 Location Location NNP work_zhhbvy463fhkbjyzltzpvocafu 52 18 Phenotype Phenotype NNP work_zhhbvy463fhkbjyzltzpvocafu 52 19 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 20 segment segment NN work_zhhbvy463fhkbjyzltzpvocafu 52 21 length length NN work_zhhbvy463fhkbjyzltzpvocafu 52 22 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 52 23 Genotype Genotype NNP work_zhhbvy463fhkbjyzltzpvocafu 52 24 Reference Reference NNP work_zhhbvy463fhkbjyzltzpvocafu 52 25 # # NN work_zhhbvy463fhkbjyzltzpvocafu 52 26 169 169 CD work_zhhbvy463fhkbjyzltzpvocafu 52 27 G g NN work_zhhbvy463fhkbjyzltzpvocafu 52 28 > > . work_zhhbvy463fhkbjyzltzpvocafu 52 29 A a DT work_zhhbvy463fhkbjyzltzpvocafu 52 30 G57S G57S NNP work_zhhbvy463fhkbjyzltzpvocafu 52 31 EC EC NNP work_zhhbvy463fhkbjyzltzpvocafu 52 32 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 33 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 34 S S NNP work_zhhbvy463fhkbjyzltzpvocafu 52 35 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 52 36 Heterozygous heterozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 52 37 30 30 CD work_zhhbvy463fhkbjyzltzpvocafu 52 38 268 268 CD work_zhhbvy463fhkbjyzltzpvocafu 52 39 T t NN work_zhhbvy463fhkbjyzltzpvocafu 52 40 > > NN work_zhhbvy463fhkbjyzltzpvocafu 52 41 C c NN work_zhhbvy463fhkbjyzltzpvocafu 52 42 C90R C90R NNP work_zhhbvy463fhkbjyzltzpvocafu 52 43 EC EC NNP work_zhhbvy463fhkbjyzltzpvocafu 52 44 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 45 Heterozygous Heterozygous NNP work_zhhbvy463fhkbjyzltzpvocafu 52 46 Present Present NNP work_zhhbvy463fhkbjyzltzpvocafu 52 47 case case NN work_zhhbvy463fhkbjyzltzpvocafu 52 48 325 325 CD work_zhhbvy463fhkbjyzltzpvocafu 52 49 T t NN work_zhhbvy463fhkbjyzltzpvocafu 52 50 > > NN work_zhhbvy463fhkbjyzltzpvocafu 52 51 C c NN work_zhhbvy463fhkbjyzltzpvocafu 52 52 C109R C109R NNP work_zhhbvy463fhkbjyzltzpvocafu 52 53 TM TM NNP work_zhhbvy463fhkbjyzltzpvocafu 52 54 I -PRON- PRP work_zhhbvy463fhkbjyzltzpvocafu 52 55 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 56 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 57 S S NNP work_zhhbvy463fhkbjyzltzpvocafu 52 58 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 52 59 Heterozygous heterozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 52 60 31 31 CD work_zhhbvy463fhkbjyzltzpvocafu 52 61 548 548 CD work_zhhbvy463fhkbjyzltzpvocafu 52 62 C c NN work_zhhbvy463fhkbjyzltzpvocafu 52 63 > > NN work_zhhbvy463fhkbjyzltzpvocafu 52 64 G g NN work_zhhbvy463fhkbjyzltzpvocafu 52 65 A183 A183 NNP work_zhhbvy463fhkbjyzltzpvocafu 52 66 G g NN work_zhhbvy463fhkbjyzltzpvocafu 52 67 TM tm NN work_zhhbvy463fhkbjyzltzpvocafu 52 68 III iii CD work_zhhbvy463fhkbjyzltzpvocafu 52 69 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 70 / / SYM work_zhhbvy463fhkbjyzltzpvocafu 52 71 WS WS NNP work_zhhbvy463fhkbjyzltzpvocafu 52 72 Homozygous Homozygous NNP work_zhhbvy463fhkbjyzltzpvocafu 52 73 29 29 CD work_zhhbvy463fhkbjyzltzpvocafu 52 74 556 556 CD work_zhhbvy463fhkbjyzltzpvocafu 52 75 G g NN work_zhhbvy463fhkbjyzltzpvocafu 52 76 > > . work_zhhbvy463fhkbjyzltzpvocafu 52 77 A a DT work_zhhbvy463fhkbjyzltzpvocafu 52 78 G186R G186R NNP work_zhhbvy463fhkbjyzltzpvocafu 52 79 TM TM NNP work_zhhbvy463fhkbjyzltzpvocafu 52 80 III iii CD work_zhhbvy463fhkbjyzltzpvocafu 52 81 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 82 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 83 L)/WS L)/WS NNP work_zhhbvy463fhkbjyzltzpvocafu 52 84 Homozygous Homozygous NNP work_zhhbvy463fhkbjyzltzpvocafu 52 85 33 33 CD work_zhhbvy463fhkbjyzltzpvocafu 52 86 601 601 CD work_zhhbvy463fhkbjyzltzpvocafu 52 87 C c NN work_zhhbvy463fhkbjyzltzpvocafu 52 88 > > . work_zhhbvy463fhkbjyzltzpvocafu 52 89 T T NNP work_zhhbvy463fhkbjyzltzpvocafu 52 90 R201X R201X NNP work_zhhbvy463fhkbjyzltzpvocafu 52 91 IL IL NNP work_zhhbvy463fhkbjyzltzpvocafu 52 92 II II NNP work_zhhbvy463fhkbjyzltzpvocafu 52 93 ABCD ABCD NNP work_zhhbvy463fhkbjyzltzpvocafu 52 94 syndrome syndrome NN work_zhhbvy463fhkbjyzltzpvocafu 52 95 Homozygous homozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 52 96 28 28 CD work_zhhbvy463fhkbjyzltzpvocafu 52 97 678 678 CD work_zhhbvy463fhkbjyzltzpvocafu 52 98 G g NN work_zhhbvy463fhkbjyzltzpvocafu 52 99 > > XX work_zhhbvy463fhkbjyzltzpvocafu 52 100 T t NN work_zhhbvy463fhkbjyzltzpvocafu 52 101 W226C W226C NNP work_zhhbvy463fhkbjyzltzpvocafu 52 102 TM TM NNP work_zhhbvy463fhkbjyzltzpvocafu 52 103 IV IV NNP work_zhhbvy463fhkbjyzltzpvocafu 52 104 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 105 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 106 S&L S&L NNP work_zhhbvy463fhkbjyzltzpvocafu 52 107 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 52 108 Heterozygous heterozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 52 109 08 08 CD work_zhhbvy463fhkbjyzltzpvocafu 52 110 707 707 CD work_zhhbvy463fhkbjyzltzpvocafu 52 111 C C NNP work_zhhbvy463fhkbjyzltzpvocafu 52 112 > > . work_zhhbvy463fhkbjyzltzpvocafu 52 113 T T NNP work_zhhbvy463fhkbjyzltzpvocafu 52 114 R253X R253X NNP work_zhhbvy463fhkbjyzltzpvocafu 52 115 EL el NN work_zhhbvy463fhkbjyzltzpvocafu 52 116 II II NNP work_zhhbvy463fhkbjyzltzpvocafu 52 117 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 118 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 119 L)/WS L)/WS NNP work_zhhbvy463fhkbjyzltzpvocafu 52 120 Heterozygous Heterozygous NNP work_zhhbvy463fhkbjyzltzpvocafu 52 121 26 26 CD work_zhhbvy463fhkbjyzltzpvocafu 52 122 801 801 CD work_zhhbvy463fhkbjyzltzpvocafu 52 123 + + SYM work_zhhbvy463fhkbjyzltzpvocafu 52 124 2 2 CD work_zhhbvy463fhkbjyzltzpvocafu 52 125 T t NN work_zhhbvy463fhkbjyzltzpvocafu 52 126 > > NN work_zhhbvy463fhkbjyzltzpvocafu 52 127 C C NNP work_zhhbvy463fhkbjyzltzpvocafu 52 128 Splicing splice VBG work_zhhbvy463fhkbjyzltzpvocafu 52 129 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 52 130 EL EL NNP work_zhhbvy463fhkbjyzltzpvocafu 52 131 II II NNP work_zhhbvy463fhkbjyzltzpvocafu 52 132 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 133 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 134 S S NNP work_zhhbvy463fhkbjyzltzpvocafu 52 135 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 52 136 Heterozygous heterozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 52 137 28 28 CD work_zhhbvy463fhkbjyzltzpvocafu 52 138 824 824 CD work_zhhbvy463fhkbjyzltzpvocafu 52 139 G g NN work_zhhbvy463fhkbjyzltzpvocafu 52 140 > > . work_zhhbvy463fhkbjyzltzpvocafu 52 141 A a DT work_zhhbvy463fhkbjyzltzpvocafu 52 142 W275X w275x CD work_zhhbvy463fhkbjyzltzpvocafu 52 143 TM TM NNP work_zhhbvy463fhkbjyzltzpvocafu 52 144 V v NN work_zhhbvy463fhkbjyzltzpvocafu 52 145 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 146 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 147 S S NNP work_zhhbvy463fhkbjyzltzpvocafu 52 148 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 52 149 Heterozygous heterozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 52 150 25 25 CD work_zhhbvy463fhkbjyzltzpvocafu 52 151 828 828 CD work_zhhbvy463fhkbjyzltzpvocafu 52 152 G g NN work_zhhbvy463fhkbjyzltzpvocafu 52 153 > > XX work_zhhbvy463fhkbjyzltzpvocafu 52 154 T t NN work_zhhbvy463fhkbjyzltzpvocafu 52 155 W276C W276C NNP work_zhhbvy463fhkbjyzltzpvocafu 52 156 TM TM NNP work_zhhbvy463fhkbjyzltzpvocafu 52 157 V v NN work_zhhbvy463fhkbjyzltzpvocafu 52 158 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 159 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 160 L&S L&S NNP work_zhhbvy463fhkbjyzltzpvocafu 52 161 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 52 162 Heterozygous heterozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 52 163 / / SYM work_zhhbvy463fhkbjyzltzpvocafu 52 164 homozygous homozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 52 165 03 03 CD work_zhhbvy463fhkbjyzltzpvocafu 52 166 874 874 CD work_zhhbvy463fhkbjyzltzpvocafu 52 167 T t NN work_zhhbvy463fhkbjyzltzpvocafu 52 168 > > NN work_zhhbvy463fhkbjyzltzpvocafu 52 169 C c NN work_zhhbvy463fhkbjyzltzpvocafu 52 170 F292L F292L NNP work_zhhbvy463fhkbjyzltzpvocafu 52 171 TM TM NNP work_zhhbvy463fhkbjyzltzpvocafu 52 172 V v NN work_zhhbvy463fhkbjyzltzpvocafu 52 173 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 174 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 175 L)/WS L)/WS NNP work_zhhbvy463fhkbjyzltzpvocafu 52 176 Heterozygous Heterozygous NNP work_zhhbvy463fhkbjyzltzpvocafu 52 177 34 34 CD work_zhhbvy463fhkbjyzltzpvocafu 52 178 878insT 878inst CD work_zhhbvy463fhkbjyzltzpvocafu 52 179 Y293L y293l CD work_zhhbvy463fhkbjyzltzpvocafu 52 180 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 181 PTC+ PTC+ NNP work_zhhbvy463fhkbjyzltzpvocafu 52 182 6 6 CD work_zhhbvy463fhkbjyzltzpvocafu 52 183 aa aa IN work_zhhbvy463fhkbjyzltzpvocafu 52 184 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 52 185 TM TM NNP work_zhhbvy463fhkbjyzltzpvocafu 52 186 V V NNP work_zhhbvy463fhkbjyzltzpvocafu 52 187 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 188 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 189 S S NNP work_zhhbvy463fhkbjyzltzpvocafu 52 190 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 52 191 Heterozygous heterozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 52 192 25 25 CD work_zhhbvy463fhkbjyzltzpvocafu 52 193 914 914 CD work_zhhbvy463fhkbjyzltzpvocafu 52 194 G g NN work_zhhbvy463fhkbjyzltzpvocafu 52 195 > > NN work_zhhbvy463fhkbjyzltzpvocafu 52 196 A a DT work_zhhbvy463fhkbjyzltzpvocafu 52 197 S305N S305N NNP work_zhhbvy463fhkbjyzltzpvocafu 52 198 IL IL NNP work_zhhbvy463fhkbjyzltzpvocafu 52 199 III iii CD work_zhhbvy463fhkbjyzltzpvocafu 52 200 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 201 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 202 S S NNP work_zhhbvy463fhkbjyzltzpvocafu 52 203 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 52 204 Heterozygous heterozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 52 205 24 24 CD work_zhhbvy463fhkbjyzltzpvocafu 52 206 928 928 CD work_zhhbvy463fhkbjyzltzpvocafu 52 207 G g NN work_zhhbvy463fhkbjyzltzpvocafu 52 208 > > NN work_zhhbvy463fhkbjyzltzpvocafu 52 209 A a NN work_zhhbvy463fhkbjyzltzpvocafu 52 210 A310 a310 NN work_zhhbvy463fhkbjyzltzpvocafu 52 211 T t NN work_zhhbvy463fhkbjyzltzpvocafu 52 212 IL il NN work_zhhbvy463fhkbjyzltzpvocafu 52 213 III iii CD work_zhhbvy463fhkbjyzltzpvocafu 52 214 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 215 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 216 S S NNP work_zhhbvy463fhkbjyzltzpvocafu 52 217 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 52 218 Heterozygous heterozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 52 219 32 32 CD work_zhhbvy463fhkbjyzltzpvocafu 52 220 955 955 CD work_zhhbvy463fhkbjyzltzpvocafu 52 221 C c NN work_zhhbvy463fhkbjyzltzpvocafu 52 222 > > NN work_zhhbvy463fhkbjyzltzpvocafu 52 223 T T NNP work_zhhbvy463fhkbjyzltzpvocafu 52 224 R319W R319W NNP work_zhhbvy463fhkbjyzltzpvocafu 52 225 IL IL NNP work_zhhbvy463fhkbjyzltzpvocafu 52 226 III iii CD work_zhhbvy463fhkbjyzltzpvocafu 52 227 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 228 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 229 S S NNP work_zhhbvy463fhkbjyzltzpvocafu 52 230 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 52 231 Heterozygous heterozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 52 232 30 30 CD work_zhhbvy463fhkbjyzltzpvocafu 52 233 1122 1122 CD work_zhhbvy463fhkbjyzltzpvocafu 52 234 G g NN work_zhhbvy463fhkbjyzltzpvocafu 52 235 > > . work_zhhbvy463fhkbjyzltzpvocafu 52 236 A a NN work_zhhbvy463fhkbjyzltzpvocafu 52 237 M374I M374I NNP work_zhhbvy463fhkbjyzltzpvocafu 52 238 TM TM NNP work_zhhbvy463fhkbjyzltzpvocafu 52 239 VII vii NN work_zhhbvy463fhkbjyzltzpvocafu 52 240 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 241 Heterozygous Heterozygous NNP work_zhhbvy463fhkbjyzltzpvocafu 52 242 04 04 CD work_zhhbvy463fhkbjyzltzpvocafu 52 243 1132delA 1132dela CD work_zhhbvy463fhkbjyzltzpvocafu 52 244 N378I n378i CD work_zhhbvy463fhkbjyzltzpvocafu 52 245 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 246 PTC+ PTC+ NNP work_zhhbvy463fhkbjyzltzpvocafu 52 247 12 12 CD work_zhhbvy463fhkbjyzltzpvocafu 52 248 aa aa NNP work_zhhbvy463fhkbjyzltzpvocafu 52 249 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 52 250 TM TM NNP work_zhhbvy463fhkbjyzltzpvocafu 52 251 VII VII NNP work_zhhbvy463fhkbjyzltzpvocafu 52 252 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 253 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 254 S S NNP work_zhhbvy463fhkbjyzltzpvocafu 52 255 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 52 256 Heterozygous heterozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 52 257 24 24 CD work_zhhbvy463fhkbjyzltzpvocafu 52 258 1148 1148 CD work_zhhbvy463fhkbjyzltzpvocafu 52 259 C c NN work_zhhbvy463fhkbjyzltzpvocafu 52 260 > > NN work_zhhbvy463fhkbjyzltzpvocafu 52 261 T T NNP work_zhhbvy463fhkbjyzltzpvocafu 52 262 P383L p383l CD work_zhhbvy463fhkbjyzltzpvocafu 52 263 TM TM NNP work_zhhbvy463fhkbjyzltzpvocafu 52 264 VII VII NNP work_zhhbvy463fhkbjyzltzpvocafu 52 265 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 266 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 267 S S NNP work_zhhbvy463fhkbjyzltzpvocafu 52 268 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 52 269 Heterozygous heterozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 52 270 30 30 CD work_zhhbvy463fhkbjyzltzpvocafu 52 271 1170 1170 CD work_zhhbvy463fhkbjyzltzpvocafu 52 272 C C NNP work_zhhbvy463fhkbjyzltzpvocafu 52 273 > > NN work_zhhbvy463fhkbjyzltzpvocafu 52 274 A a DT work_zhhbvy463fhkbjyzltzpvocafu 52 275 S390R S390R NNP work_zhhbvy463fhkbjyzltzpvocafu 52 276 C C NNP work_zhhbvy463fhkbjyzltzpvocafu 52 277 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 52 278 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 52 279 L L NNP work_zhhbvy463fhkbjyzltzpvocafu 52 280 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 52 281 Heterozygous heterozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 52 282 31 31 CD work_zhhbvy463fhkbjyzltzpvocafu 52 283 ABCD ABCD NNP work_zhhbvy463fhkbjyzltzpvocafu 52 284 = = SYM work_zhhbvy463fhkbjyzltzpvocafu 52 285 albinism albinism NN work_zhhbvy463fhkbjyzltzpvocafu 52 286 , , , work_zhhbvy463fhkbjyzltzpvocafu 52 287 black black JJ work_zhhbvy463fhkbjyzltzpvocafu 52 288 lock lock NN work_zhhbvy463fhkbjyzltzpvocafu 52 289 , , , work_zhhbvy463fhkbjyzltzpvocafu 52 290 cell cell NN work_zhhbvy463fhkbjyzltzpvocafu 52 291 migration migration NN work_zhhbvy463fhkbjyzltzpvocafu 52 292 disorder disorder NN work_zhhbvy463fhkbjyzltzpvocafu 52 293 of of IN work_zhhbvy463fhkbjyzltzpvocafu 52 294 the the DT work_zhhbvy463fhkbjyzltzpvocafu 52 295 neurocytes neurocyte NNS work_zhhbvy463fhkbjyzltzpvocafu 52 296 of of IN work_zhhbvy463fhkbjyzltzpvocafu 52 297 the the DT work_zhhbvy463fhkbjyzltzpvocafu 52 298 gut gut NN work_zhhbvy463fhkbjyzltzpvocafu 52 299 , , , work_zhhbvy463fhkbjyzltzpvocafu 52 300 and and CC work_zhhbvy463fhkbjyzltzpvocafu 52 301 deafness deafness NN work_zhhbvy463fhkbjyzltzpvocafu 52 302 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 52 303 C C NNP work_zhhbvy463fhkbjyzltzpvocafu 52 304 = = SYM work_zhhbvy463fhkbjyzltzpvocafu 52 305 carboxyl carboxyl NN work_zhhbvy463fhkbjyzltzpvocafu 52 306 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 52 307 terminal terminal NN work_zhhbvy463fhkbjyzltzpvocafu 52 308 region region NN work_zhhbvy463fhkbjyzltzpvocafu 52 309 and and CC work_zhhbvy463fhkbjyzltzpvocafu 52 310 adjacent adjacent JJ work_zhhbvy463fhkbjyzltzpvocafu 52 311 to to IN work_zhhbvy463fhkbjyzltzpvocafu 52 312 TM7 TM7 NNP work_zhhbvy463fhkbjyzltzpvocafu 52 313 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 52 314 EC EC NNP work_zhhbvy463fhkbjyzltzpvocafu 52 315 = = SYM work_zhhbvy463fhkbjyzltzpvocafu 52 316 extracellular extracellular NNP work_zhhbvy463fhkbjyzltzpvocafu 52 317 domain domain NN work_zhhbvy463fhkbjyzltzpvocafu 52 318 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 52 319 EL EL NNP work_zhhbvy463fhkbjyzltzpvocafu 52 320 = = SYM work_zhhbvy463fhkbjyzltzpvocafu 52 321 extracellular extracellular NNP work_zhhbvy463fhkbjyzltzpvocafu 52 322 loop loop NN work_zhhbvy463fhkbjyzltzpvocafu 52 323 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 52 324 IL IL NNP work_zhhbvy463fhkbjyzltzpvocafu 52 325 = = SYM work_zhhbvy463fhkbjyzltzpvocafu 52 326 intracellular intracellular JJ work_zhhbvy463fhkbjyzltzpvocafu 52 327 loop loop NN work_zhhbvy463fhkbjyzltzpvocafu 52 328 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 52 329 L l NN work_zhhbvy463fhkbjyzltzpvocafu 52 330 = = SYM work_zhhbvy463fhkbjyzltzpvocafu 52 331 long long JJ work_zhhbvy463fhkbjyzltzpvocafu 52 332 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 52 333 segment segment NN work_zhhbvy463fhkbjyzltzpvocafu 52 334 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 52 335 PTC PTC NNP work_zhhbvy463fhkbjyzltzpvocafu 52 336 = = SYM work_zhhbvy463fhkbjyzltzpvocafu 52 337 premature premature JJ work_zhhbvy463fhkbjyzltzpvocafu 52 338 termination termination NN work_zhhbvy463fhkbjyzltzpvocafu 52 339 of of IN work_zhhbvy463fhkbjyzltzpvocafu 52 340 codon codon NNP work_zhhbvy463fhkbjyzltzpvocafu 52 341 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 52 342 S s NN work_zhhbvy463fhkbjyzltzpvocafu 52 343 = = SYM work_zhhbvy463fhkbjyzltzpvocafu 52 344 short short JJ work_zhhbvy463fhkbjyzltzpvocafu 52 345 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 52 346 segment segment NN work_zhhbvy463fhkbjyzltzpvocafu 52 347 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 52 348 TM TM NNP work_zhhbvy463fhkbjyzltzpvocafu 52 349 = = SYM work_zhhbvy463fhkbjyzltzpvocafu 52 350 transmembrane transmembrane NN work_zhhbvy463fhkbjyzltzpvocafu 52 351 domain domain NN work_zhhbvy463fhkbjyzltzpvocafu 52 352 . . . work_zhhbvy463fhkbjyzltzpvocafu 53 1 353J 353j CD work_zhhbvy463fhkbjyzltzpvocafu 53 2 Formos Formos NNP work_zhhbvy463fhkbjyzltzpvocafu 53 3 Med Med NNP work_zhhbvy463fhkbjyzltzpvocafu 53 4 Assoc Assoc NNP work_zhhbvy463fhkbjyzltzpvocafu 53 5 | | CD work_zhhbvy463fhkbjyzltzpvocafu 53 6 2006 2006 CD work_zhhbvy463fhkbjyzltzpvocafu 53 7 • • NNP work_zhhbvy463fhkbjyzltzpvocafu 53 8 Vol Vol NNP work_zhhbvy463fhkbjyzltzpvocafu 53 9 105 105 CD work_zhhbvy463fhkbjyzltzpvocafu 53 10 • • NNP work_zhhbvy463fhkbjyzltzpvocafu 53 11 No no DT work_zhhbvy463fhkbjyzltzpvocafu 53 12 4 4 CD work_zhhbvy463fhkbjyzltzpvocafu 53 13 EDNRB ednrb NN work_zhhbvy463fhkbjyzltzpvocafu 53 14 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 53 15 in in IN work_zhhbvy463fhkbjyzltzpvocafu 53 16 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 53 17 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 53 18 a a DT work_zhhbvy463fhkbjyzltzpvocafu 53 19 basic basic JJ work_zhhbvy463fhkbjyzltzpvocafu 53 20 hydrophilic hydrophilic JJ work_zhhbvy463fhkbjyzltzpvocafu 53 21 amino amino NN work_zhhbvy463fhkbjyzltzpvocafu 53 22 acid acid NN work_zhhbvy463fhkbjyzltzpvocafu 53 23 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 53 24 arginine arginine NNP work_zhhbvy463fhkbjyzltzpvocafu 53 25 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 53 26 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 53 27 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 53 28 3 3 LS work_zhhbvy463fhkbjyzltzpvocafu 53 29 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 53 30 this this DT work_zhhbvy463fhkbjyzltzpvocafu 53 31 region region NN work_zhhbvy463fhkbjyzltzpvocafu 53 32 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 53 33 highly highly RB work_zhhbvy463fhkbjyzltzpvocafu 53 34 conserved conserve VBN work_zhhbvy463fhkbjyzltzpvocafu 53 35 between between IN work_zhhbvy463fhkbjyzltzpvocafu 53 36 species specie NNS work_zhhbvy463fhkbjyzltzpvocafu 53 37 , , , work_zhhbvy463fhkbjyzltzpvocafu 53 38 which which WDT work_zhhbvy463fhkbjyzltzpvocafu 53 39 probably probably RB work_zhhbvy463fhkbjyzltzpvocafu 53 40 indicates indicate VBZ work_zhhbvy463fhkbjyzltzpvocafu 53 41 an an DT work_zhhbvy463fhkbjyzltzpvocafu 53 42 important important JJ work_zhhbvy463fhkbjyzltzpvocafu 53 43 functional functional JJ work_zhhbvy463fhkbjyzltzpvocafu 53 44 role role NN work_zhhbvy463fhkbjyzltzpvocafu 53 45 in in IN work_zhhbvy463fhkbjyzltzpvocafu 53 46 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 53 47 signaling signal VBG work_zhhbvy463fhkbjyzltzpvocafu 53 48 . . . work_zhhbvy463fhkbjyzltzpvocafu 54 1 The the DT work_zhhbvy463fhkbjyzltzpvocafu 54 2 C90R C90R NNP work_zhhbvy463fhkbjyzltzpvocafu 54 3 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 54 4 may may MD work_zhhbvy463fhkbjyzltzpvocafu 54 5 change change VB work_zhhbvy463fhkbjyzltzpvocafu 54 6 ligand ligand NN work_zhhbvy463fhkbjyzltzpvocafu 54 7 binding binding NN work_zhhbvy463fhkbjyzltzpvocafu 54 8 . . . work_zhhbvy463fhkbjyzltzpvocafu 55 1 Functional functional JJ work_zhhbvy463fhkbjyzltzpvocafu 55 2 analysis analysis NN work_zhhbvy463fhkbjyzltzpvocafu 55 3 of of IN work_zhhbvy463fhkbjyzltzpvocafu 55 4 the the DT work_zhhbvy463fhkbjyzltzpvocafu 55 5 C90R C90R NNP work_zhhbvy463fhkbjyzltzpvocafu 55 6 protein protein NN work_zhhbvy463fhkbjyzltzpvocafu 55 7 will will MD work_zhhbvy463fhkbjyzltzpvocafu 55 8 be be VB work_zhhbvy463fhkbjyzltzpvocafu 55 9 necessary necessary JJ work_zhhbvy463fhkbjyzltzpvocafu 55 10 to to TO work_zhhbvy463fhkbjyzltzpvocafu 55 11 determine determine VB work_zhhbvy463fhkbjyzltzpvocafu 55 12 the the DT work_zhhbvy463fhkbjyzltzpvocafu 55 13 effect effect NN work_zhhbvy463fhkbjyzltzpvocafu 55 14 of of IN work_zhhbvy463fhkbjyzltzpvocafu 55 15 the the DT work_zhhbvy463fhkbjyzltzpvocafu 55 16 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 55 17 on on IN work_zhhbvy463fhkbjyzltzpvocafu 55 18 the the DT work_zhhbvy463fhkbjyzltzpvocafu 55 19 function function NN work_zhhbvy463fhkbjyzltzpvocafu 55 20 of of IN work_zhhbvy463fhkbjyzltzpvocafu 55 21 the the DT work_zhhbvy463fhkbjyzltzpvocafu 55 22 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 55 23 protein protein NN work_zhhbvy463fhkbjyzltzpvocafu 55 24 . . . work_zhhbvy463fhkbjyzltzpvocafu 56 1 In in IN work_zhhbvy463fhkbjyzltzpvocafu 56 2 conclusion conclusion NN work_zhhbvy463fhkbjyzltzpvocafu 56 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 56 4 the the DT work_zhhbvy463fhkbjyzltzpvocafu 56 5 detection detection NN work_zhhbvy463fhkbjyzltzpvocafu 56 6 of of IN work_zhhbvy463fhkbjyzltzpvocafu 56 7 a a DT work_zhhbvy463fhkbjyzltzpvocafu 56 8 de de FW work_zhhbvy463fhkbjyzltzpvocafu 56 9 novo novo NNP work_zhhbvy463fhkbjyzltzpvocafu 56 10 novel novel NN work_zhhbvy463fhkbjyzltzpvocafu 56 11 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 56 12 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 56 13 C90R C90R NNP work_zhhbvy463fhkbjyzltzpvocafu 56 14 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 56 15 of of IN work_zhhbvy463fhkbjyzltzpvocafu 56 16 the the DT work_zhhbvy463fhkbjyzltzpvocafu 56 17 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 56 18 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 56 19 in in IN work_zhhbvy463fhkbjyzltzpvocafu 56 20 our -PRON- PRP$ work_zhhbvy463fhkbjyzltzpvocafu 56 21 pa- pa- NN work_zhhbvy463fhkbjyzltzpvocafu 56 22 tient tient NN work_zhhbvy463fhkbjyzltzpvocafu 56 23 suggests suggest VBZ work_zhhbvy463fhkbjyzltzpvocafu 56 24 that that IN work_zhhbvy463fhkbjyzltzpvocafu 56 25 dysfunction dysfunction NN work_zhhbvy463fhkbjyzltzpvocafu 56 26 of of IN work_zhhbvy463fhkbjyzltzpvocafu 56 27 the the DT work_zhhbvy463fhkbjyzltzpvocafu 56 28 endothelin- endothelin- NN work_zhhbvy463fhkbjyzltzpvocafu 56 29 B b NN work_zhhbvy463fhkbjyzltzpvocafu 56 30 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 56 31 has have VBZ work_zhhbvy463fhkbjyzltzpvocafu 56 32 a a DT work_zhhbvy463fhkbjyzltzpvocafu 56 33 role role NN work_zhhbvy463fhkbjyzltzpvocafu 56 34 in in IN work_zhhbvy463fhkbjyzltzpvocafu 56 35 the the DT work_zhhbvy463fhkbjyzltzpvocafu 56 36 etiology etiology NN work_zhhbvy463fhkbjyzltzpvocafu 56 37 of of IN work_zhhbvy463fhkbjyzltzpvocafu 56 38 some some DT work_zhhbvy463fhkbjyzltzpvocafu 56 39 cases case NNS work_zhhbvy463fhkbjyzltzpvocafu 56 40 of of IN work_zhhbvy463fhkbjyzltzpvocafu 56 41 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 56 42 , , , work_zhhbvy463fhkbjyzltzpvocafu 56 43 especially especially RB work_zhhbvy463fhkbjyzltzpvocafu 56 44 short short JJ work_zhhbvy463fhkbjyzltzpvocafu 56 45 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 56 46 segment segment NN work_zhhbvy463fhkbjyzltzpvocafu 56 47 HSCR HSCR NNP work_zhhbvy463fhkbjyzltzpvocafu 56 48 . . . work_zhhbvy463fhkbjyzltzpvocafu 57 1 Acknowledgments acknowledgment NNS work_zhhbvy463fhkbjyzltzpvocafu 57 2 This this DT work_zhhbvy463fhkbjyzltzpvocafu 57 3 study study NN work_zhhbvy463fhkbjyzltzpvocafu 57 4 was be VBD work_zhhbvy463fhkbjyzltzpvocafu 57 5 supported support VBN work_zhhbvy463fhkbjyzltzpvocafu 57 6 by by IN work_zhhbvy463fhkbjyzltzpvocafu 57 7 research research NN work_zhhbvy463fhkbjyzltzpvocafu 57 8 grant grant NN work_zhhbvy463fhkbjyzltzpvocafu 57 9 NCK- NCK- NNP work_zhhbvy463fhkbjyzltzpvocafu 57 10 UH UH NNP work_zhhbvy463fhkbjyzltzpvocafu 57 11 93 93 CD work_zhhbvy463fhkbjyzltzpvocafu 57 12 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 57 13 046 046 CD work_zhhbvy463fhkbjyzltzpvocafu 57 14 from from IN work_zhhbvy463fhkbjyzltzpvocafu 57 15 National National NNP work_zhhbvy463fhkbjyzltzpvocafu 57 16 Cheng Cheng NNP work_zhhbvy463fhkbjyzltzpvocafu 57 17 Kung Kung NNP work_zhhbvy463fhkbjyzltzpvocafu 57 18 University University NNP work_zhhbvy463fhkbjyzltzpvocafu 57 19 Hospital Hospital NNP work_zhhbvy463fhkbjyzltzpvocafu 57 20 , , , work_zhhbvy463fhkbjyzltzpvocafu 57 21 Taiwan Taiwan NNP work_zhhbvy463fhkbjyzltzpvocafu 57 22 . . . work_zhhbvy463fhkbjyzltzpvocafu 58 1 References reference NNS work_zhhbvy463fhkbjyzltzpvocafu 58 2 1 1 CD work_zhhbvy463fhkbjyzltzpvocafu 58 3 . . . work_zhhbvy463fhkbjyzltzpvocafu 59 1 Edery edery NN work_zhhbvy463fhkbjyzltzpvocafu 59 2 P p NN work_zhhbvy463fhkbjyzltzpvocafu 59 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 59 4 Lyonnet Lyonnet NNP work_zhhbvy463fhkbjyzltzpvocafu 59 5 S S NNP work_zhhbvy463fhkbjyzltzpvocafu 59 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 59 7 Mulligan Mulligan NNP work_zhhbvy463fhkbjyzltzpvocafu 59 8 LM LM NNP work_zhhbvy463fhkbjyzltzpvocafu 59 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 59 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 59 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 59 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 60 1 Mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 60 2 of of IN work_zhhbvy463fhkbjyzltzpvocafu 60 3 the the DT work_zhhbvy463fhkbjyzltzpvocafu 60 4 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 60 5 proto proto NN work_zhhbvy463fhkbjyzltzpvocafu 60 6 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 60 7 oncogene oncogene NN work_zhhbvy463fhkbjyzltzpvocafu 60 8 in in IN work_zhhbvy463fhkbjyzltzpvocafu 60 9 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 60 10 ’s ’s POS work_zhhbvy463fhkbjyzltzpvocafu 60 11 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 60 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 61 1 Nature nature NN work_zhhbvy463fhkbjyzltzpvocafu 61 2 1994 1994 CD work_zhhbvy463fhkbjyzltzpvocafu 61 3 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 61 4 367:378–80 367:378–80 CD work_zhhbvy463fhkbjyzltzpvocafu 61 5 . . . work_zhhbvy463fhkbjyzltzpvocafu 62 1 2 2 LS work_zhhbvy463fhkbjyzltzpvocafu 62 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 63 1 Doray Doray NNP work_zhhbvy463fhkbjyzltzpvocafu 63 2 B B NNP work_zhhbvy463fhkbjyzltzpvocafu 63 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 63 4 Salomon Salomon NNP work_zhhbvy463fhkbjyzltzpvocafu 63 5 R R NNP work_zhhbvy463fhkbjyzltzpvocafu 63 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 63 7 Amiel Amiel NNP work_zhhbvy463fhkbjyzltzpvocafu 63 8 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 63 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 63 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 63 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 63 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 64 1 Mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 64 2 of of IN work_zhhbvy463fhkbjyzltzpvocafu 64 3 the the DT work_zhhbvy463fhkbjyzltzpvocafu 64 4 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 64 5 ligand ligand NNP work_zhhbvy463fhkbjyzltzpvocafu 64 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 64 7 neurturin neurturin NNP work_zhhbvy463fhkbjyzltzpvocafu 64 8 , , , work_zhhbvy463fhkbjyzltzpvocafu 64 9 supports support VBZ work_zhhbvy463fhkbjyzltzpvocafu 64 10 multigenic multigenic JJ work_zhhbvy463fhkbjyzltzpvocafu 64 11 inheritance inheritance NN work_zhhbvy463fhkbjyzltzpvocafu 64 12 in in IN work_zhhbvy463fhkbjyzltzpvocafu 64 13 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 64 14 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 64 15 . . . work_zhhbvy463fhkbjyzltzpvocafu 65 1 Hum Hum NNP work_zhhbvy463fhkbjyzltzpvocafu 65 2 Mol Mol NNP work_zhhbvy463fhkbjyzltzpvocafu 65 3 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 65 4 1998;7:1449–52 1998;7:1449–52 CD work_zhhbvy463fhkbjyzltzpvocafu 65 5 . . . work_zhhbvy463fhkbjyzltzpvocafu 66 1 3 3 LS work_zhhbvy463fhkbjyzltzpvocafu 66 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 67 1 Shah Shah VBG work_zhhbvy463fhkbjyzltzpvocafu 67 2 KN KN NNP work_zhhbvy463fhkbjyzltzpvocafu 67 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 67 4 Dalal Dalal NNP work_zhhbvy463fhkbjyzltzpvocafu 67 5 SJ SJ NNP work_zhhbvy463fhkbjyzltzpvocafu 67 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 67 7 Desai Desai NNP work_zhhbvy463fhkbjyzltzpvocafu 67 8 MP MP NNP work_zhhbvy463fhkbjyzltzpvocafu 67 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 67 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 67 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 67 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 68 1 White white JJ work_zhhbvy463fhkbjyzltzpvocafu 68 2 forelock forelock NN work_zhhbvy463fhkbjyzltzpvocafu 68 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 68 4 pig- pig- NN work_zhhbvy463fhkbjyzltzpvocafu 68 5 mentary mentary JJ work_zhhbvy463fhkbjyzltzpvocafu 68 6 disorder disorder NN work_zhhbvy463fhkbjyzltzpvocafu 68 7 of of IN work_zhhbvy463fhkbjyzltzpvocafu 68 8 irides iris NNS work_zhhbvy463fhkbjyzltzpvocafu 68 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 68 10 and and CC work_zhhbvy463fhkbjyzltzpvocafu 68 11 long long JJ work_zhhbvy463fhkbjyzltzpvocafu 68 12 segment segment NN work_zhhbvy463fhkbjyzltzpvocafu 68 13 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 68 14 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 68 15 : : : work_zhhbvy463fhkbjyzltzpvocafu 68 16 possible possible JJ work_zhhbvy463fhkbjyzltzpvocafu 68 17 variant variant NN work_zhhbvy463fhkbjyzltzpvocafu 68 18 of of IN work_zhhbvy463fhkbjyzltzpvocafu 68 19 Waardenburg Waardenburg NNP work_zhhbvy463fhkbjyzltzpvocafu 68 20 syndrome syndrome NN work_zhhbvy463fhkbjyzltzpvocafu 68 21 . . . work_zhhbvy463fhkbjyzltzpvocafu 69 1 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 69 2 Pediatr Pediatr NNP work_zhhbvy463fhkbjyzltzpvocafu 69 3 1981;99:432–5 1981;99:432–5 CD work_zhhbvy463fhkbjyzltzpvocafu 69 4 . . . work_zhhbvy463fhkbjyzltzpvocafu 70 1 4 4 LS work_zhhbvy463fhkbjyzltzpvocafu 70 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 71 1 Puffenberger Puffenberger NNP work_zhhbvy463fhkbjyzltzpvocafu 71 2 EG EG NNP work_zhhbvy463fhkbjyzltzpvocafu 71 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 71 4 Hosoda Hosoda NNP work_zhhbvy463fhkbjyzltzpvocafu 71 5 K K NNP work_zhhbvy463fhkbjyzltzpvocafu 71 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 71 7 Washington Washington NNP work_zhhbvy463fhkbjyzltzpvocafu 71 8 SS SS NNP work_zhhbvy463fhkbjyzltzpvocafu 71 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 71 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 71 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 71 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 72 1 A a DT work_zhhbvy463fhkbjyzltzpvocafu 72 2 mis- mis- NN work_zhhbvy463fhkbjyzltzpvocafu 72 3 sense sense NN work_zhhbvy463fhkbjyzltzpvocafu 72 4 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 72 5 of of IN work_zhhbvy463fhkbjyzltzpvocafu 72 6 the the DT work_zhhbvy463fhkbjyzltzpvocafu 72 7 endothelin endothelin NNP work_zhhbvy463fhkbjyzltzpvocafu 72 8 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 72 9 B B NNP work_zhhbvy463fhkbjyzltzpvocafu 72 10 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 72 11 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 72 12 in in IN work_zhhbvy463fhkbjyzltzpvocafu 72 13 mul- mul- NNP work_zhhbvy463fhkbjyzltzpvocafu 72 14 tigenic tigenic JJ work_zhhbvy463fhkbjyzltzpvocafu 72 15 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 72 16 ’s ’s POS work_zhhbvy463fhkbjyzltzpvocafu 72 17 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 72 18 . . . work_zhhbvy463fhkbjyzltzpvocafu 73 1 Cell cell NN work_zhhbvy463fhkbjyzltzpvocafu 73 2 1994;79:1257–66 1994;79:1257–66 CD work_zhhbvy463fhkbjyzltzpvocafu 73 3 . . . work_zhhbvy463fhkbjyzltzpvocafu 74 1 5 5 CD work_zhhbvy463fhkbjyzltzpvocafu 74 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 75 1 Hofstra Hofstra NNP work_zhhbvy463fhkbjyzltzpvocafu 75 2 RM RM NNP work_zhhbvy463fhkbjyzltzpvocafu 75 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 75 4 Osinga Osinga NNP work_zhhbvy463fhkbjyzltzpvocafu 75 5 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 75 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 75 7 Tan Tan NNP work_zhhbvy463fhkbjyzltzpvocafu 75 8 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 75 9 Sindhunata Sindhunata NNP work_zhhbvy463fhkbjyzltzpvocafu 75 10 G G NNP work_zhhbvy463fhkbjyzltzpvocafu 75 11 , , , work_zhhbvy463fhkbjyzltzpvocafu 75 12 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 75 13 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 75 14 . . . work_zhhbvy463fhkbjyzltzpvocafu 76 1 A a DT work_zhhbvy463fhkbjyzltzpvocafu 76 2 homozy- homozy- JJ work_zhhbvy463fhkbjyzltzpvocafu 76 3 gous gous JJ work_zhhbvy463fhkbjyzltzpvocafu 76 4 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 76 5 in in IN work_zhhbvy463fhkbjyzltzpvocafu 76 6 the the DT work_zhhbvy463fhkbjyzltzpvocafu 76 7 endothelin-3 endothelin-3 NNP work_zhhbvy463fhkbjyzltzpvocafu 76 8 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 76 9 associated associate VBN work_zhhbvy463fhkbjyzltzpvocafu 76 10 with with IN work_zhhbvy463fhkbjyzltzpvocafu 76 11 a a DT work_zhhbvy463fhkbjyzltzpvocafu 76 12 combined combine VBN work_zhhbvy463fhkbjyzltzpvocafu 76 13 Waardenburg Waardenburg NNP work_zhhbvy463fhkbjyzltzpvocafu 76 14 type type NN work_zhhbvy463fhkbjyzltzpvocafu 76 15 2 2 CD work_zhhbvy463fhkbjyzltzpvocafu 76 16 and and CC work_zhhbvy463fhkbjyzltzpvocafu 76 17 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 76 18 pheno- pheno- NN work_zhhbvy463fhkbjyzltzpvocafu 76 19 type type NN work_zhhbvy463fhkbjyzltzpvocafu 76 20 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 76 21 Shah Shah NNP work_zhhbvy463fhkbjyzltzpvocafu 76 22 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 76 23 Waardenburg Waardenburg NNP work_zhhbvy463fhkbjyzltzpvocafu 76 24 syndrome syndrome NN work_zhhbvy463fhkbjyzltzpvocafu 76 25 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 76 26 . . . work_zhhbvy463fhkbjyzltzpvocafu 77 1 Nat Nat NNP work_zhhbvy463fhkbjyzltzpvocafu 77 2 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 77 3 1996;12 1996;12 CD work_zhhbvy463fhkbjyzltzpvocafu 77 4 : : : work_zhhbvy463fhkbjyzltzpvocafu 77 5 445–7 445–7 CD work_zhhbvy463fhkbjyzltzpvocafu 77 6 . . . work_zhhbvy463fhkbjyzltzpvocafu 78 1 6 6 CD work_zhhbvy463fhkbjyzltzpvocafu 78 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 79 1 Pingault Pingault NNP work_zhhbvy463fhkbjyzltzpvocafu 79 2 V V NNP work_zhhbvy463fhkbjyzltzpvocafu 79 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 79 4 Bondurand Bondurand NNP work_zhhbvy463fhkbjyzltzpvocafu 79 5 N N NNP work_zhhbvy463fhkbjyzltzpvocafu 79 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 79 7 Kuhlbrodt Kuhlbrodt NNP work_zhhbvy463fhkbjyzltzpvocafu 79 8 K K NNP work_zhhbvy463fhkbjyzltzpvocafu 79 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 79 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 79 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 79 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 80 1 SOX10 SOX10 NNP work_zhhbvy463fhkbjyzltzpvocafu 80 2 muta- muta- JJ work_zhhbvy463fhkbjyzltzpvocafu 80 3 tions tion NNS work_zhhbvy463fhkbjyzltzpvocafu 80 4 in in IN work_zhhbvy463fhkbjyzltzpvocafu 80 5 patients patient NNS work_zhhbvy463fhkbjyzltzpvocafu 80 6 with with IN work_zhhbvy463fhkbjyzltzpvocafu 80 7 Waardenburg Waardenburg NNP work_zhhbvy463fhkbjyzltzpvocafu 80 8 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 80 9 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 80 10 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 80 11 . . . work_zhhbvy463fhkbjyzltzpvocafu 81 1 Nat Nat NNP work_zhhbvy463fhkbjyzltzpvocafu 81 2 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 81 3 1998;18:171–3 1998;18:171–3 CD work_zhhbvy463fhkbjyzltzpvocafu 81 4 . . . work_zhhbvy463fhkbjyzltzpvocafu 82 1 7 7 LS work_zhhbvy463fhkbjyzltzpvocafu 82 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 83 1 Attie Attie NNP work_zhhbvy463fhkbjyzltzpvocafu 83 2 T T NNP work_zhhbvy463fhkbjyzltzpvocafu 83 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 83 4 Pelet Pelet NNP work_zhhbvy463fhkbjyzltzpvocafu 83 5 A A NNP work_zhhbvy463fhkbjyzltzpvocafu 83 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 83 7 Edery Edery NNP work_zhhbvy463fhkbjyzltzpvocafu 83 8 P P NNP work_zhhbvy463fhkbjyzltzpvocafu 83 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 83 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 83 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 83 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 84 1 Diversity diversity NN work_zhhbvy463fhkbjyzltzpvocafu 84 2 of of IN work_zhhbvy463fhkbjyzltzpvocafu 84 3 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 84 4 proto- proto- NN work_zhhbvy463fhkbjyzltzpvocafu 84 5 oncogene oncogene NN work_zhhbvy463fhkbjyzltzpvocafu 84 6 mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 84 7 in in IN work_zhhbvy463fhkbjyzltzpvocafu 84 8 familial familial JJ work_zhhbvy463fhkbjyzltzpvocafu 84 9 and and CC work_zhhbvy463fhkbjyzltzpvocafu 84 10 sporadic sporadic JJ work_zhhbvy463fhkbjyzltzpvocafu 84 11 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 84 12 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 84 13 . . . work_zhhbvy463fhkbjyzltzpvocafu 85 1 Hum Hum NNP work_zhhbvy463fhkbjyzltzpvocafu 85 2 Mol Mol NNP work_zhhbvy463fhkbjyzltzpvocafu 85 3 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 85 4 1995;4:1381–6 1995;4:1381–6 CD work_zhhbvy463fhkbjyzltzpvocafu 85 5 . . . work_zhhbvy463fhkbjyzltzpvocafu 86 1 8 8 LS work_zhhbvy463fhkbjyzltzpvocafu 86 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 87 1 Chakravarti Chakravarti NNP work_zhhbvy463fhkbjyzltzpvocafu 87 2 A. a. NN work_zhhbvy463fhkbjyzltzpvocafu 87 3 Endothelin Endothelin NNP work_zhhbvy463fhkbjyzltzpvocafu 87 4 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 87 5 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 87 6 mediated mediate VBN work_zhhbvy463fhkbjyzltzpvocafu 87 7 signaling signaling NN work_zhhbvy463fhkbjyzltzpvocafu 87 8 in in IN work_zhhbvy463fhkbjyzltzpvocafu 87 9 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 87 10 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 87 11 . . . work_zhhbvy463fhkbjyzltzpvocafu 88 1 Hum Hum NNP work_zhhbvy463fhkbjyzltzpvocafu 88 2 Mol Mol NNP work_zhhbvy463fhkbjyzltzpvocafu 88 3 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 88 4 1996;5:303–7 1996;5:303–7 CD work_zhhbvy463fhkbjyzltzpvocafu 88 5 . . . work_zhhbvy463fhkbjyzltzpvocafu 89 1 9 9 CD work_zhhbvy463fhkbjyzltzpvocafu 89 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 90 1 Svensson Svensson NNP work_zhhbvy463fhkbjyzltzpvocafu 90 2 PJ PJ NNP work_zhhbvy463fhkbjyzltzpvocafu 90 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 90 4 Tapper Tapper NNP work_zhhbvy463fhkbjyzltzpvocafu 90 5 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 90 6 Persson Persson NNP work_zhhbvy463fhkbjyzltzpvocafu 90 7 M M NNP work_zhhbvy463fhkbjyzltzpvocafu 90 8 , , , work_zhhbvy463fhkbjyzltzpvocafu 90 9 Anvret Anvret NNP work_zhhbvy463fhkbjyzltzpvocafu 90 10 M M NNP work_zhhbvy463fhkbjyzltzpvocafu 90 11 , , , work_zhhbvy463fhkbjyzltzpvocafu 90 12 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 90 13 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 90 14 . . . work_zhhbvy463fhkbjyzltzpvocafu 91 1 Mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 91 2 in in IN work_zhhbvy463fhkbjyzltzpvocafu 91 3 the the DT work_zhhbvy463fhkbjyzltzpvocafu 91 4 endothelin endothelin JJ work_zhhbvy463fhkbjyzltzpvocafu 91 5 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 91 6 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 91 7 B b NN work_zhhbvy463fhkbjyzltzpvocafu 91 8 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 91 9 in in IN work_zhhbvy463fhkbjyzltzpvocafu 91 10 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 91 11 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 91 12 in in IN work_zhhbvy463fhkbjyzltzpvocafu 91 13 Sweden Sweden NNP work_zhhbvy463fhkbjyzltzpvocafu 91 14 . . . work_zhhbvy463fhkbjyzltzpvocafu 92 1 Clin Clin NNP work_zhhbvy463fhkbjyzltzpvocafu 92 2 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 92 3 1999;55:215–7 1999;55:215–7 CD work_zhhbvy463fhkbjyzltzpvocafu 92 4 . . . work_zhhbvy463fhkbjyzltzpvocafu 93 1 10 10 CD work_zhhbvy463fhkbjyzltzpvocafu 93 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 94 1 Benish Benish NNP work_zhhbvy463fhkbjyzltzpvocafu 94 2 BM BM NNP work_zhhbvy463fhkbjyzltzpvocafu 94 3 . . . work_zhhbvy463fhkbjyzltzpvocafu 95 1 The the DT work_zhhbvy463fhkbjyzltzpvocafu 95 2 neurocristopathies neurocristopathie NNS work_zhhbvy463fhkbjyzltzpvocafu 95 3 : : : work_zhhbvy463fhkbjyzltzpvocafu 95 4 a a DT work_zhhbvy463fhkbjyzltzpvocafu 95 5 unifying unifying JJ work_zhhbvy463fhkbjyzltzpvocafu 95 6 concept concept NN work_zhhbvy463fhkbjyzltzpvocafu 95 7 of of IN work_zhhbvy463fhkbjyzltzpvocafu 95 8 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 95 9 arising arise VBG work_zhhbvy463fhkbjyzltzpvocafu 95 10 in in IN work_zhhbvy463fhkbjyzltzpvocafu 95 11 neural neural JJ work_zhhbvy463fhkbjyzltzpvocafu 95 12 crest crest NNP work_zhhbvy463fhkbjyzltzpvocafu 95 13 development development NN work_zhhbvy463fhkbjyzltzpvocafu 95 14 . . . work_zhhbvy463fhkbjyzltzpvocafu 96 1 Hum Hum NNP work_zhhbvy463fhkbjyzltzpvocafu 96 2 Pathol Pathol NNP work_zhhbvy463fhkbjyzltzpvocafu 96 3 1975;6:128 1975;6:128 CD work_zhhbvy463fhkbjyzltzpvocafu 96 4 . . . work_zhhbvy463fhkbjyzltzpvocafu 97 1 [ [ -LRB- work_zhhbvy463fhkbjyzltzpvocafu 97 2 Letter letter NN work_zhhbvy463fhkbjyzltzpvocafu 97 3 ] ] -RRB- work_zhhbvy463fhkbjyzltzpvocafu 97 4 11 11 CD work_zhhbvy463fhkbjyzltzpvocafu 97 5 . . . work_zhhbvy463fhkbjyzltzpvocafu 98 1 Whitehouse whitehouse VB work_zhhbvy463fhkbjyzltzpvocafu 98 2 FR FR NNP work_zhhbvy463fhkbjyzltzpvocafu 98 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 98 4 Kernohan Kernohan NNP work_zhhbvy463fhkbjyzltzpvocafu 98 5 JW JW NNP work_zhhbvy463fhkbjyzltzpvocafu 98 6 . . . work_zhhbvy463fhkbjyzltzpvocafu 99 1 Myenteric Myenteric NNP work_zhhbvy463fhkbjyzltzpvocafu 99 2 plexuses plexus NNS work_zhhbvy463fhkbjyzltzpvocafu 99 3 in in IN work_zhhbvy463fhkbjyzltzpvocafu 99 4 con- con- NNP work_zhhbvy463fhkbjyzltzpvocafu 99 5 genital genital NNP work_zhhbvy463fhkbjyzltzpvocafu 99 6 megacolon megacolon NN work_zhhbvy463fhkbjyzltzpvocafu 99 7 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 99 8 study study NN work_zhhbvy463fhkbjyzltzpvocafu 99 9 of of IN work_zhhbvy463fhkbjyzltzpvocafu 99 10 11 11 CD work_zhhbvy463fhkbjyzltzpvocafu 99 11 cases case NNS work_zhhbvy463fhkbjyzltzpvocafu 99 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 100 1 Arch Arch NNP work_zhhbvy463fhkbjyzltzpvocafu 100 2 Intern Intern NNP work_zhhbvy463fhkbjyzltzpvocafu 100 3 Med Med NNP work_zhhbvy463fhkbjyzltzpvocafu 100 4 1948;82:75–111 1948;82:75–111 CD work_zhhbvy463fhkbjyzltzpvocafu 100 5 . . . work_zhhbvy463fhkbjyzltzpvocafu 101 1 12 12 CD work_zhhbvy463fhkbjyzltzpvocafu 101 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 102 1 Badner Badner NNP work_zhhbvy463fhkbjyzltzpvocafu 102 2 JA JA NNP work_zhhbvy463fhkbjyzltzpvocafu 102 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 102 4 Sieber Sieber NNP work_zhhbvy463fhkbjyzltzpvocafu 102 5 WK WK NNP work_zhhbvy463fhkbjyzltzpvocafu 102 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 102 7 Garver Garver NNP work_zhhbvy463fhkbjyzltzpvocafu 102 8 KL KL NNP work_zhhbvy463fhkbjyzltzpvocafu 102 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 102 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 102 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 102 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 103 1 A a DT work_zhhbvy463fhkbjyzltzpvocafu 103 2 genetic genetic JJ work_zhhbvy463fhkbjyzltzpvocafu 103 3 study study NN work_zhhbvy463fhkbjyzltzpvocafu 103 4 of of IN work_zhhbvy463fhkbjyzltzpvocafu 103 5 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 103 6 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 103 7 . . . work_zhhbvy463fhkbjyzltzpvocafu 104 1 Am be VBP work_zhhbvy463fhkbjyzltzpvocafu 104 2 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 104 3 Hum Hum NNP work_zhhbvy463fhkbjyzltzpvocafu 104 4 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 104 5 1990;46:568–80 1990;46:568–80 NNP work_zhhbvy463fhkbjyzltzpvocafu 104 6 . . . work_zhhbvy463fhkbjyzltzpvocafu 105 1 13 13 CD work_zhhbvy463fhkbjyzltzpvocafu 105 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 106 1 Lyonnet Lyonnet NNP work_zhhbvy463fhkbjyzltzpvocafu 106 2 S S NNP work_zhhbvy463fhkbjyzltzpvocafu 106 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 106 4 Bolino Bolino NNP work_zhhbvy463fhkbjyzltzpvocafu 106 5 A A NNP work_zhhbvy463fhkbjyzltzpvocafu 106 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 106 7 Pelet Pelet NNP work_zhhbvy463fhkbjyzltzpvocafu 106 8 A A NNP work_zhhbvy463fhkbjyzltzpvocafu 106 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 106 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 106 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 106 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 107 1 A a DT work_zhhbvy463fhkbjyzltzpvocafu 107 2 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 107 3 for for IN work_zhhbvy463fhkbjyzltzpvocafu 107 4 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 107 5 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 107 6 maps map NNS work_zhhbvy463fhkbjyzltzpvocafu 107 7 to to IN work_zhhbvy463fhkbjyzltzpvocafu 107 8 the the DT work_zhhbvy463fhkbjyzltzpvocafu 107 9 proximal proximal JJ work_zhhbvy463fhkbjyzltzpvocafu 107 10 long long JJ work_zhhbvy463fhkbjyzltzpvocafu 107 11 arm arm NN work_zhhbvy463fhkbjyzltzpvocafu 107 12 of of IN work_zhhbvy463fhkbjyzltzpvocafu 107 13 chromosome chromosome NN work_zhhbvy463fhkbjyzltzpvocafu 107 14 10 10 CD work_zhhbvy463fhkbjyzltzpvocafu 107 15 . . . work_zhhbvy463fhkbjyzltzpvocafu 108 1 Nat Nat NNP work_zhhbvy463fhkbjyzltzpvocafu 108 2 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 108 3 1993;4:346–50 1993;4:346–50 CD work_zhhbvy463fhkbjyzltzpvocafu 108 4 . . . work_zhhbvy463fhkbjyzltzpvocafu 109 1 14 14 CD work_zhhbvy463fhkbjyzltzpvocafu 109 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 110 1 Angrist Angrist NNP work_zhhbvy463fhkbjyzltzpvocafu 110 2 M M NNP work_zhhbvy463fhkbjyzltzpvocafu 110 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 110 4 Kauffman Kauffman NNP work_zhhbvy463fhkbjyzltzpvocafu 110 5 E E NNP work_zhhbvy463fhkbjyzltzpvocafu 110 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 110 7 Slaugenhaupt Slaugenhaupt NNP work_zhhbvy463fhkbjyzltzpvocafu 110 8 SA SA NNP work_zhhbvy463fhkbjyzltzpvocafu 110 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 110 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 110 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 110 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 111 1 A a DT work_zhhbvy463fhkbjyzltzpvocafu 111 2 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 111 3 for for IN work_zhhbvy463fhkbjyzltzpvocafu 111 4 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 111 5 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 111 6 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 111 7 megacolon megacolon NN work_zhhbvy463fhkbjyzltzpvocafu 111 8 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 111 9 in in IN work_zhhbvy463fhkbjyzltzpvocafu 111 10 the the DT work_zhhbvy463fhkbjyzltzpvocafu 111 11 pericentromeric pericentromeric JJ work_zhhbvy463fhkbjyzltzpvocafu 111 12 region region NN work_zhhbvy463fhkbjyzltzpvocafu 111 13 of of IN work_zhhbvy463fhkbjyzltzpvocafu 111 14 human human JJ work_zhhbvy463fhkbjyzltzpvocafu 111 15 chromosome chromosome NN work_zhhbvy463fhkbjyzltzpvocafu 111 16 10 10 CD work_zhhbvy463fhkbjyzltzpvocafu 111 17 . . . work_zhhbvy463fhkbjyzltzpvocafu 112 1 Nat Nat NNP work_zhhbvy463fhkbjyzltzpvocafu 112 2 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 112 3 1993;4 1993;4 VBZ work_zhhbvy463fhkbjyzltzpvocafu 112 4 : : : work_zhhbvy463fhkbjyzltzpvocafu 112 5 351–6 351–6 CD work_zhhbvy463fhkbjyzltzpvocafu 112 6 . . . work_zhhbvy463fhkbjyzltzpvocafu 113 1 15 15 CD work_zhhbvy463fhkbjyzltzpvocafu 113 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 114 1 Angrist Angrist NNP work_zhhbvy463fhkbjyzltzpvocafu 114 2 M M NNP work_zhhbvy463fhkbjyzltzpvocafu 114 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 114 4 Bolk Bolk NNP work_zhhbvy463fhkbjyzltzpvocafu 114 5 S S NNP work_zhhbvy463fhkbjyzltzpvocafu 114 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 114 7 Thiel Thiel NNP work_zhhbvy463fhkbjyzltzpvocafu 114 8 B B NNP work_zhhbvy463fhkbjyzltzpvocafu 114 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 114 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 114 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 114 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 115 1 Mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 115 2 analysis analysis NN work_zhhbvy463fhkbjyzltzpvocafu 115 3 of of IN work_zhhbvy463fhkbjyzltzpvocafu 115 4 the the DT work_zhhbvy463fhkbjyzltzpvocafu 115 5 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 115 6 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 115 7 tyrosine tyrosine NN work_zhhbvy463fhkbjyzltzpvocafu 115 8 kinase kinase NN work_zhhbvy463fhkbjyzltzpvocafu 115 9 in in IN work_zhhbvy463fhkbjyzltzpvocafu 115 10 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 115 11 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 115 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 116 1 Hum Hum NNP work_zhhbvy463fhkbjyzltzpvocafu 116 2 Mol Mol NNP work_zhhbvy463fhkbjyzltzpvocafu 116 3 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 116 4 1995;4:821–30 1995;4:821–30 NNP work_zhhbvy463fhkbjyzltzpvocafu 116 5 . . . work_zhhbvy463fhkbjyzltzpvocafu 117 1 16 16 CD work_zhhbvy463fhkbjyzltzpvocafu 117 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 118 1 Romeo Romeo NNP work_zhhbvy463fhkbjyzltzpvocafu 118 2 G G NNP work_zhhbvy463fhkbjyzltzpvocafu 118 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 118 4 Ronchetto Ronchetto NNP work_zhhbvy463fhkbjyzltzpvocafu 118 5 P P NNP work_zhhbvy463fhkbjyzltzpvocafu 118 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 118 7 Luo Luo NNP work_zhhbvy463fhkbjyzltzpvocafu 118 8 Y Y NNP work_zhhbvy463fhkbjyzltzpvocafu 118 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 118 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 118 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 118 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 119 1 Point point NN work_zhhbvy463fhkbjyzltzpvocafu 119 2 mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 119 3 affect- affect- NNP work_zhhbvy463fhkbjyzltzpvocafu 119 4 ing ing NNP work_zhhbvy463fhkbjyzltzpvocafu 119 5 the the DT work_zhhbvy463fhkbjyzltzpvocafu 119 6 tyrosine tyrosine JJ work_zhhbvy463fhkbjyzltzpvocafu 119 7 kinase kinase NN work_zhhbvy463fhkbjyzltzpvocafu 119 8 domain domain NN work_zhhbvy463fhkbjyzltzpvocafu 119 9 of of IN work_zhhbvy463fhkbjyzltzpvocafu 119 10 the the DT work_zhhbvy463fhkbjyzltzpvocafu 119 11 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 119 12 proto proto NN work_zhhbvy463fhkbjyzltzpvocafu 119 13 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 119 14 oncogene oncogene NN work_zhhbvy463fhkbjyzltzpvocafu 119 15 in in IN work_zhhbvy463fhkbjyzltzpvocafu 119 16 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 119 17 ’s ’s POS work_zhhbvy463fhkbjyzltzpvocafu 119 18 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 119 19 . . . work_zhhbvy463fhkbjyzltzpvocafu 120 1 Nature nature NN work_zhhbvy463fhkbjyzltzpvocafu 120 2 1994;367:377–8 1994;367:377–8 CD work_zhhbvy463fhkbjyzltzpvocafu 120 3 . . . work_zhhbvy463fhkbjyzltzpvocafu 121 1 17 17 CD work_zhhbvy463fhkbjyzltzpvocafu 121 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 122 1 Yin Yin NNP work_zhhbvy463fhkbjyzltzpvocafu 122 2 L L NNP work_zhhbvy463fhkbjyzltzpvocafu 122 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 122 4 Barone Barone NNP work_zhhbvy463fhkbjyzltzpvocafu 122 5 V V NNP work_zhhbvy463fhkbjyzltzpvocafu 122 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 122 7 Seri Seri NNP work_zhhbvy463fhkbjyzltzpvocafu 122 8 M M NNP work_zhhbvy463fhkbjyzltzpvocafu 122 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 122 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 122 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 122 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 123 1 Heterogeneity heterogeneity NN work_zhhbvy463fhkbjyzltzpvocafu 123 2 and and CC work_zhhbvy463fhkbjyzltzpvocafu 123 3 low low JJ work_zhhbvy463fhkbjyzltzpvocafu 123 4 de- de- NN work_zhhbvy463fhkbjyzltzpvocafu 123 5 tection tection NN work_zhhbvy463fhkbjyzltzpvocafu 123 6 rate rate NN work_zhhbvy463fhkbjyzltzpvocafu 123 7 of of IN work_zhhbvy463fhkbjyzltzpvocafu 123 8 RET RET NNP work_zhhbvy463fhkbjyzltzpvocafu 123 9 mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 123 10 in in IN work_zhhbvy463fhkbjyzltzpvocafu 123 11 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 123 12 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 123 13 . . . work_zhhbvy463fhkbjyzltzpvocafu 124 1 Eur Eur NNP work_zhhbvy463fhkbjyzltzpvocafu 124 2 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 124 3 Hum Hum NNP work_zhhbvy463fhkbjyzltzpvocafu 124 4 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 124 5 1994;2:272–80 1994;2:272–80 NNP work_zhhbvy463fhkbjyzltzpvocafu 124 6 . . . work_zhhbvy463fhkbjyzltzpvocafu 125 1 18 18 CD work_zhhbvy463fhkbjyzltzpvocafu 125 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 126 1 Rubanyi Rubanyi NNP work_zhhbvy463fhkbjyzltzpvocafu 126 2 GM GM NNP work_zhhbvy463fhkbjyzltzpvocafu 126 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 126 4 Polokoff Polokoff NNP work_zhhbvy463fhkbjyzltzpvocafu 126 5 MA MA NNP work_zhhbvy463fhkbjyzltzpvocafu 126 6 . . . work_zhhbvy463fhkbjyzltzpvocafu 127 1 Endothelins endothelin NNS work_zhhbvy463fhkbjyzltzpvocafu 127 2 : : : work_zhhbvy463fhkbjyzltzpvocafu 127 3 molecular molecular JJ work_zhhbvy463fhkbjyzltzpvocafu 127 4 bio- bio- NN work_zhhbvy463fhkbjyzltzpvocafu 127 5 logy logy NN work_zhhbvy463fhkbjyzltzpvocafu 127 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 127 7 biochemistry biochemistry NN work_zhhbvy463fhkbjyzltzpvocafu 127 8 , , , work_zhhbvy463fhkbjyzltzpvocafu 127 9 pharmacology pharmacology NN work_zhhbvy463fhkbjyzltzpvocafu 127 10 , , , work_zhhbvy463fhkbjyzltzpvocafu 127 11 physiology physiology NN work_zhhbvy463fhkbjyzltzpvocafu 127 12 , , , work_zhhbvy463fhkbjyzltzpvocafu 127 13 and and CC work_zhhbvy463fhkbjyzltzpvocafu 127 14 patho- patho- JJ work_zhhbvy463fhkbjyzltzpvocafu 127 15 physiology physiology NN work_zhhbvy463fhkbjyzltzpvocafu 127 16 . . . work_zhhbvy463fhkbjyzltzpvocafu 128 1 Pharmacol Pharmacol NNP work_zhhbvy463fhkbjyzltzpvocafu 128 2 Rev Rev NNP work_zhhbvy463fhkbjyzltzpvocafu 128 3 1994;46:325–415 1994;46:325–415 CD work_zhhbvy463fhkbjyzltzpvocafu 128 4 . . . work_zhhbvy463fhkbjyzltzpvocafu 129 1 19 19 CD work_zhhbvy463fhkbjyzltzpvocafu 129 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 130 1 Vane Vane NNP work_zhhbvy463fhkbjyzltzpvocafu 130 2 J. J. NNP work_zhhbvy463fhkbjyzltzpvocafu 130 3 Endothelins Endothelins NNP work_zhhbvy463fhkbjyzltzpvocafu 130 4 come come VBD work_zhhbvy463fhkbjyzltzpvocafu 130 5 home home RB work_zhhbvy463fhkbjyzltzpvocafu 130 6 to to TO work_zhhbvy463fhkbjyzltzpvocafu 130 7 roost roost VB work_zhhbvy463fhkbjyzltzpvocafu 130 8 . . . work_zhhbvy463fhkbjyzltzpvocafu 131 1 Nature nature NN work_zhhbvy463fhkbjyzltzpvocafu 131 2 1990;348 1990;348 CD work_zhhbvy463fhkbjyzltzpvocafu 131 3 : : : work_zhhbvy463fhkbjyzltzpvocafu 131 4 673 673 CD work_zhhbvy463fhkbjyzltzpvocafu 131 5 . . . work_zhhbvy463fhkbjyzltzpvocafu 132 1 20 20 CD work_zhhbvy463fhkbjyzltzpvocafu 132 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 133 1 Sakurai Sakurai NNP work_zhhbvy463fhkbjyzltzpvocafu 133 2 T T NNP work_zhhbvy463fhkbjyzltzpvocafu 133 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 133 4 Yanagisawa Yanagisawa NNP work_zhhbvy463fhkbjyzltzpvocafu 133 5 M M NNP work_zhhbvy463fhkbjyzltzpvocafu 133 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 133 7 Masaki Masaki NNP work_zhhbvy463fhkbjyzltzpvocafu 133 8 T. T. NNP work_zhhbvy463fhkbjyzltzpvocafu 133 9 Molecular Molecular NNP work_zhhbvy463fhkbjyzltzpvocafu 133 10 characteri- characteri- NN work_zhhbvy463fhkbjyzltzpvocafu 133 11 zation zation NN work_zhhbvy463fhkbjyzltzpvocafu 133 12 of of IN work_zhhbvy463fhkbjyzltzpvocafu 133 13 endothelin endothelin NNP work_zhhbvy463fhkbjyzltzpvocafu 133 14 receptors receptor NNS work_zhhbvy463fhkbjyzltzpvocafu 133 15 . . . work_zhhbvy463fhkbjyzltzpvocafu 134 1 Trends Trends NNPS work_zhhbvy463fhkbjyzltzpvocafu 134 2 Pharmacol Pharmacol NNP work_zhhbvy463fhkbjyzltzpvocafu 134 3 Sci Sci NNP work_zhhbvy463fhkbjyzltzpvocafu 134 4 1992 1992 CD work_zhhbvy463fhkbjyzltzpvocafu 134 5 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 134 6 13:103–8 13:103–8 NNP work_zhhbvy463fhkbjyzltzpvocafu 134 7 . . . work_zhhbvy463fhkbjyzltzpvocafu 135 1 21 21 CD work_zhhbvy463fhkbjyzltzpvocafu 135 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 136 1 Shin Shin NNP work_zhhbvy463fhkbjyzltzpvocafu 136 2 MK MK NNP work_zhhbvy463fhkbjyzltzpvocafu 136 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 136 4 Levorse Levorse NNP work_zhhbvy463fhkbjyzltzpvocafu 136 5 JM JM NNP work_zhhbvy463fhkbjyzltzpvocafu 136 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 136 7 Ingram Ingram NNP work_zhhbvy463fhkbjyzltzpvocafu 136 8 RS RS NNP work_zhhbvy463fhkbjyzltzpvocafu 136 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 136 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 136 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 136 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 137 1 The the DT work_zhhbvy463fhkbjyzltzpvocafu 137 2 temporal temporal JJ work_zhhbvy463fhkbjyzltzpvocafu 137 3 re- re- RB work_zhhbvy463fhkbjyzltzpvocafu 137 4 quirement quirement JJ work_zhhbvy463fhkbjyzltzpvocafu 137 5 for for IN work_zhhbvy463fhkbjyzltzpvocafu 137 6 endothelin endothelin JJ work_zhhbvy463fhkbjyzltzpvocafu 137 7 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 137 8 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 137 9 B b NN work_zhhbvy463fhkbjyzltzpvocafu 137 10 signalling signalling NN work_zhhbvy463fhkbjyzltzpvocafu 137 11 during during IN work_zhhbvy463fhkbjyzltzpvocafu 137 12 neu- neu- NNP work_zhhbvy463fhkbjyzltzpvocafu 137 13 ral ral NNP work_zhhbvy463fhkbjyzltzpvocafu 137 14 crest crest NNP work_zhhbvy463fhkbjyzltzpvocafu 137 15 development development NN work_zhhbvy463fhkbjyzltzpvocafu 137 16 . . . work_zhhbvy463fhkbjyzltzpvocafu 138 1 Nature nature NN work_zhhbvy463fhkbjyzltzpvocafu 138 2 1999;402:496–501 1999;402:496–501 CD work_zhhbvy463fhkbjyzltzpvocafu 138 3 . . . work_zhhbvy463fhkbjyzltzpvocafu 139 1 22 22 CD work_zhhbvy463fhkbjyzltzpvocafu 139 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 140 1 Arai Arai NNP work_zhhbvy463fhkbjyzltzpvocafu 140 2 H H NNP work_zhhbvy463fhkbjyzltzpvocafu 140 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 140 4 Nakao Nakao NNP work_zhhbvy463fhkbjyzltzpvocafu 140 5 K K NNP work_zhhbvy463fhkbjyzltzpvocafu 140 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 140 7 Takaya Takaya NNP work_zhhbvy463fhkbjyzltzpvocafu 140 8 K K NNP work_zhhbvy463fhkbjyzltzpvocafu 140 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 140 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 140 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 140 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 141 1 The the DT work_zhhbvy463fhkbjyzltzpvocafu 141 2 human human NN work_zhhbvy463fhkbjyzltzpvocafu 141 3 endothelin- endothelin- NN work_zhhbvy463fhkbjyzltzpvocafu 141 4 B b NN work_zhhbvy463fhkbjyzltzpvocafu 141 5 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 141 6 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 141 7 . . . work_zhhbvy463fhkbjyzltzpvocafu 142 1 Structural structural JJ work_zhhbvy463fhkbjyzltzpvocafu 142 2 organization organization NN work_zhhbvy463fhkbjyzltzpvocafu 142 3 and and CC work_zhhbvy463fhkbjyzltzpvocafu 142 4 chromosomal chromosomal NN work_zhhbvy463fhkbjyzltzpvocafu 142 5 assignment assignment NN work_zhhbvy463fhkbjyzltzpvocafu 142 6 . . . work_zhhbvy463fhkbjyzltzpvocafu 143 1 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 143 2 Biol Biol NNP work_zhhbvy463fhkbjyzltzpvocafu 143 3 Chem Chem NNP work_zhhbvy463fhkbjyzltzpvocafu 143 4 1993;268:3463–70 1993;268:3463–70 NNP work_zhhbvy463fhkbjyzltzpvocafu 143 5 . . . work_zhhbvy463fhkbjyzltzpvocafu 144 1 23 23 CD work_zhhbvy463fhkbjyzltzpvocafu 144 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 145 1 Sakamoto Sakamoto NNP work_zhhbvy463fhkbjyzltzpvocafu 145 2 A A NNP work_zhhbvy463fhkbjyzltzpvocafu 145 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 145 4 Yanagisawa Yanagisawa NNP work_zhhbvy463fhkbjyzltzpvocafu 145 5 M M NNP work_zhhbvy463fhkbjyzltzpvocafu 145 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 145 7 Sakurai Sakurai NNP work_zhhbvy463fhkbjyzltzpvocafu 145 8 T T NNP work_zhhbvy463fhkbjyzltzpvocafu 145 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 145 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 145 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 145 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 146 1 Cloning cloning JJ work_zhhbvy463fhkbjyzltzpvocafu 146 2 and and CC work_zhhbvy463fhkbjyzltzpvocafu 146 3 functional functional JJ work_zhhbvy463fhkbjyzltzpvocafu 146 4 expression expression NN work_zhhbvy463fhkbjyzltzpvocafu 146 5 of of IN work_zhhbvy463fhkbjyzltzpvocafu 146 6 human human JJ work_zhhbvy463fhkbjyzltzpvocafu 146 7 cDNA cdna NN work_zhhbvy463fhkbjyzltzpvocafu 146 8 for for IN work_zhhbvy463fhkbjyzltzpvocafu 146 9 the the DT work_zhhbvy463fhkbjyzltzpvocafu 146 10 ETB ETB NNP work_zhhbvy463fhkbjyzltzpvocafu 146 11 endo- endo- JJ work_zhhbvy463fhkbjyzltzpvocafu 146 12 thelin thelin NN work_zhhbvy463fhkbjyzltzpvocafu 146 13 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 146 14 . . . work_zhhbvy463fhkbjyzltzpvocafu 147 1 Biochem Biochem NNP work_zhhbvy463fhkbjyzltzpvocafu 147 2 Biophys Biophys NNP work_zhhbvy463fhkbjyzltzpvocafu 147 3 Res Res NNP work_zhhbvy463fhkbjyzltzpvocafu 147 4 Commun Commun NNP work_zhhbvy463fhkbjyzltzpvocafu 147 5 1991;178 1991;178 CD work_zhhbvy463fhkbjyzltzpvocafu 147 6 : : : work_zhhbvy463fhkbjyzltzpvocafu 147 7 656–63 656–63 CD work_zhhbvy463fhkbjyzltzpvocafu 147 8 . . . work_zhhbvy463fhkbjyzltzpvocafu 148 1 24 24 CD work_zhhbvy463fhkbjyzltzpvocafu 148 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 149 1 Inagaki Inagaki NNP work_zhhbvy463fhkbjyzltzpvocafu 149 2 H H NNP work_zhhbvy463fhkbjyzltzpvocafu 149 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 149 4 Bishop Bishop NNP work_zhhbvy463fhkbjyzltzpvocafu 149 5 AE AE NNP work_zhhbvy463fhkbjyzltzpvocafu 149 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 149 7 Escrig Escrig NNP work_zhhbvy463fhkbjyzltzpvocafu 149 8 C C NNP work_zhhbvy463fhkbjyzltzpvocafu 149 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 149 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 149 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 149 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 150 1 Localization localization NN work_zhhbvy463fhkbjyzltzpvocafu 150 2 of of IN work_zhhbvy463fhkbjyzltzpvocafu 150 3 endothelin endothelin NN work_zhhbvy463fhkbjyzltzpvocafu 150 4 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 150 5 like like JJ work_zhhbvy463fhkbjyzltzpvocafu 150 6 immunoreactivity immunoreactivity NN work_zhhbvy463fhkbjyzltzpvocafu 150 7 and and CC work_zhhbvy463fhkbjyzltzpvocafu 150 8 endothelin endothelin NNP work_zhhbvy463fhkbjyzltzpvocafu 150 9 bind- bind- NNP work_zhhbvy463fhkbjyzltzpvocafu 150 10 ing ing NNP work_zhhbvy463fhkbjyzltzpvocafu 150 11 sites site NNS work_zhhbvy463fhkbjyzltzpvocafu 150 12 in in IN work_zhhbvy463fhkbjyzltzpvocafu 150 13 human human JJ work_zhhbvy463fhkbjyzltzpvocafu 150 14 colon colon NN work_zhhbvy463fhkbjyzltzpvocafu 150 15 . . . work_zhhbvy463fhkbjyzltzpvocafu 151 1 Gastroenterology gastroenterology NN work_zhhbvy463fhkbjyzltzpvocafu 151 2 1991;101 1991;101 CD work_zhhbvy463fhkbjyzltzpvocafu 151 3 : : : work_zhhbvy463fhkbjyzltzpvocafu 151 4 47–54 47–54 CD work_zhhbvy463fhkbjyzltzpvocafu 151 5 . . . work_zhhbvy463fhkbjyzltzpvocafu 152 1 25 25 CD work_zhhbvy463fhkbjyzltzpvocafu 152 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 153 1 Auricchio Auricchio NNP work_zhhbvy463fhkbjyzltzpvocafu 153 2 A A NNP work_zhhbvy463fhkbjyzltzpvocafu 153 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 153 4 Casari Casari NNP work_zhhbvy463fhkbjyzltzpvocafu 153 5 G G NNP work_zhhbvy463fhkbjyzltzpvocafu 153 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 153 7 Staiano Staiano NNP work_zhhbvy463fhkbjyzltzpvocafu 153 8 A A NNP work_zhhbvy463fhkbjyzltzpvocafu 153 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 153 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 153 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 153 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 154 1 Endothelin Endothelin NNP work_zhhbvy463fhkbjyzltzpvocafu 154 2 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 154 3 B B NNP work_zhhbvy463fhkbjyzltzpvocafu 154 4 re- re- JJ work_zhhbvy463fhkbjyzltzpvocafu 154 5 ceptor ceptor NN work_zhhbvy463fhkbjyzltzpvocafu 154 6 mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 154 7 in in IN work_zhhbvy463fhkbjyzltzpvocafu 154 8 patients patient NNS work_zhhbvy463fhkbjyzltzpvocafu 154 9 with with IN work_zhhbvy463fhkbjyzltzpvocafu 154 10 isolated isolated JJ work_zhhbvy463fhkbjyzltzpvocafu 154 11 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 154 12 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 154 13 from from IN work_zhhbvy463fhkbjyzltzpvocafu 154 14 a a DT work_zhhbvy463fhkbjyzltzpvocafu 154 15 non non JJ work_zhhbvy463fhkbjyzltzpvocafu 154 16 - - JJ work_zhhbvy463fhkbjyzltzpvocafu 154 17 inbred inbred JJ work_zhhbvy463fhkbjyzltzpvocafu 154 18 population population NN work_zhhbvy463fhkbjyzltzpvocafu 154 19 . . . work_zhhbvy463fhkbjyzltzpvocafu 155 1 Hum Hum NNP work_zhhbvy463fhkbjyzltzpvocafu 155 2 Mol Mol NNP work_zhhbvy463fhkbjyzltzpvocafu 155 3 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 155 4 1996;5:351–4 1996;5:351–4 CD work_zhhbvy463fhkbjyzltzpvocafu 155 5 . . . work_zhhbvy463fhkbjyzltzpvocafu 156 1 26 26 CD work_zhhbvy463fhkbjyzltzpvocafu 156 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 157 1 Kusafuka Kusafuka NNP work_zhhbvy463fhkbjyzltzpvocafu 157 2 T T NNP work_zhhbvy463fhkbjyzltzpvocafu 157 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 157 4 Wang Wang NNP work_zhhbvy463fhkbjyzltzpvocafu 157 5 Y Y NNP work_zhhbvy463fhkbjyzltzpvocafu 157 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 157 7 Puri Puri NNP work_zhhbvy463fhkbjyzltzpvocafu 157 8 P. P. NNP work_zhhbvy463fhkbjyzltzpvocafu 157 9 Novel Novel NNP work_zhhbvy463fhkbjyzltzpvocafu 157 10 mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 157 11 of of IN work_zhhbvy463fhkbjyzltzpvocafu 157 12 the the DT work_zhhbvy463fhkbjyzltzpvocafu 157 13 endothelin endothelin JJ work_zhhbvy463fhkbjyzltzpvocafu 157 14 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 157 15 B B NNP work_zhhbvy463fhkbjyzltzpvocafu 157 16 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 157 17 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 157 18 in in IN work_zhhbvy463fhkbjyzltzpvocafu 157 19 isolated isolated JJ work_zhhbvy463fhkbjyzltzpvocafu 157 20 patients patient NNS work_zhhbvy463fhkbjyzltzpvocafu 157 21 with with IN work_zhhbvy463fhkbjyzltzpvocafu 157 22 Hirsch- Hirsch- NNP work_zhhbvy463fhkbjyzltzpvocafu 157 23 sprung sprung NNP work_zhhbvy463fhkbjyzltzpvocafu 157 24 ’s ’s NN work_zhhbvy463fhkbjyzltzpvocafu 157 25 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 157 26 . . . work_zhhbvy463fhkbjyzltzpvocafu 158 1 Hum Hum NNP work_zhhbvy463fhkbjyzltzpvocafu 158 2 Mol Mol NNP work_zhhbvy463fhkbjyzltzpvocafu 158 3 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 158 4 1996;5:347–9 1996;5:347–9 CD work_zhhbvy463fhkbjyzltzpvocafu 158 5 . . . work_zhhbvy463fhkbjyzltzpvocafu 159 1 354 354 CD work_zhhbvy463fhkbjyzltzpvocafu 159 2 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 159 3 Formos Formos NNP work_zhhbvy463fhkbjyzltzpvocafu 159 4 Med Med NNP work_zhhbvy463fhkbjyzltzpvocafu 159 5 Assoc Assoc NNP work_zhhbvy463fhkbjyzltzpvocafu 159 6 | | CD work_zhhbvy463fhkbjyzltzpvocafu 159 7 2006 2006 CD work_zhhbvy463fhkbjyzltzpvocafu 159 8 • • NNP work_zhhbvy463fhkbjyzltzpvocafu 159 9 Vol Vol NNP work_zhhbvy463fhkbjyzltzpvocafu 159 10 105 105 CD work_zhhbvy463fhkbjyzltzpvocafu 159 11 • • NNP work_zhhbvy463fhkbjyzltzpvocafu 159 12 No no DT work_zhhbvy463fhkbjyzltzpvocafu 159 13 4 4 CD work_zhhbvy463fhkbjyzltzpvocafu 159 14 W.C. W.C. NNP work_zhhbvy463fhkbjyzltzpvocafu 159 15 Chen Chen NNP work_zhhbvy463fhkbjyzltzpvocafu 159 16 , , , work_zhhbvy463fhkbjyzltzpvocafu 159 17 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 159 18 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 159 19 27 27 CD work_zhhbvy463fhkbjyzltzpvocafu 159 20 . . . work_zhhbvy463fhkbjyzltzpvocafu 160 1 Syrris Syrris NNP work_zhhbvy463fhkbjyzltzpvocafu 160 2 P P NNP work_zhhbvy463fhkbjyzltzpvocafu 160 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 160 4 Carter Carter NNP work_zhhbvy463fhkbjyzltzpvocafu 160 5 ND ND NNP work_zhhbvy463fhkbjyzltzpvocafu 160 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 160 7 Patton Patton NNP work_zhhbvy463fhkbjyzltzpvocafu 160 8 MA MA NNP work_zhhbvy463fhkbjyzltzpvocafu 160 9 . . . work_zhhbvy463fhkbjyzltzpvocafu 161 1 Novel novel JJ work_zhhbvy463fhkbjyzltzpvocafu 161 2 nonsense nonsense NN work_zhhbvy463fhkbjyzltzpvocafu 161 3 muta- muta- NN work_zhhbvy463fhkbjyzltzpvocafu 161 4 tion tion NN work_zhhbvy463fhkbjyzltzpvocafu 161 5 of of IN work_zhhbvy463fhkbjyzltzpvocafu 161 6 the the DT work_zhhbvy463fhkbjyzltzpvocafu 161 7 endothelin endothelin NNP work_zhhbvy463fhkbjyzltzpvocafu 161 8 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 161 9 B B NNP work_zhhbvy463fhkbjyzltzpvocafu 161 10 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 161 11 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 161 12 in in IN work_zhhbvy463fhkbjyzltzpvocafu 161 13 a a DT work_zhhbvy463fhkbjyzltzpvocafu 161 14 family family NN work_zhhbvy463fhkbjyzltzpvocafu 161 15 with with IN work_zhhbvy463fhkbjyzltzpvocafu 161 16 Waardenburg Waardenburg NNP work_zhhbvy463fhkbjyzltzpvocafu 161 17 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 161 18 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 161 19 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 161 20 . . . work_zhhbvy463fhkbjyzltzpvocafu 162 1 Am be VBP work_zhhbvy463fhkbjyzltzpvocafu 162 2 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 162 3 Med Med NNP work_zhhbvy463fhkbjyzltzpvocafu 162 4 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 162 5 1999;87:69–71 1999;87:69–71 NNS work_zhhbvy463fhkbjyzltzpvocafu 162 6 . . . work_zhhbvy463fhkbjyzltzpvocafu 163 1 28 28 CD work_zhhbvy463fhkbjyzltzpvocafu 163 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 164 1 Verheij Verheij NNP work_zhhbvy463fhkbjyzltzpvocafu 164 2 JB JB NNP work_zhhbvy463fhkbjyzltzpvocafu 164 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 164 4 Kunze Kunze NNP work_zhhbvy463fhkbjyzltzpvocafu 164 5 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 164 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 164 7 Osinga Osinga NNP work_zhhbvy463fhkbjyzltzpvocafu 164 8 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 164 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 164 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 164 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 164 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 165 1 ABCD ABCD NNP work_zhhbvy463fhkbjyzltzpvocafu 165 2 syndrome syndrome NN work_zhhbvy463fhkbjyzltzpvocafu 165 3 is be VBZ work_zhhbvy463fhkbjyzltzpvocafu 165 4 caused cause VBN work_zhhbvy463fhkbjyzltzpvocafu 165 5 by by IN work_zhhbvy463fhkbjyzltzpvocafu 165 6 a a DT work_zhhbvy463fhkbjyzltzpvocafu 165 7 homozygous homozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 165 8 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 165 9 in in IN work_zhhbvy463fhkbjyzltzpvocafu 165 10 the the DT work_zhhbvy463fhkbjyzltzpvocafu 165 11 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 165 12 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 165 13 . . . work_zhhbvy463fhkbjyzltzpvocafu 166 1 Am be VBP work_zhhbvy463fhkbjyzltzpvocafu 166 2 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 166 3 Med Med NNP work_zhhbvy463fhkbjyzltzpvocafu 166 4 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 166 5 2002;108:223–5 2002;108:223–5 CD work_zhhbvy463fhkbjyzltzpvocafu 166 6 . . . work_zhhbvy463fhkbjyzltzpvocafu 167 1 29 29 CD work_zhhbvy463fhkbjyzltzpvocafu 167 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 168 1 Inoue Inoue NNP work_zhhbvy463fhkbjyzltzpvocafu 168 2 M M NNP work_zhhbvy463fhkbjyzltzpvocafu 168 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 168 4 Hosoda Hosoda NNP work_zhhbvy463fhkbjyzltzpvocafu 168 5 K K NNP work_zhhbvy463fhkbjyzltzpvocafu 168 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 168 7 Imura Imura NNP work_zhhbvy463fhkbjyzltzpvocafu 168 8 K K NNP work_zhhbvy463fhkbjyzltzpvocafu 168 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 168 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 168 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 168 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 169 1 Mutational mutational JJ work_zhhbvy463fhkbjyzltzpvocafu 169 2 analysis analysis NN work_zhhbvy463fhkbjyzltzpvocafu 169 3 of of IN work_zhhbvy463fhkbjyzltzpvocafu 169 4 the the DT work_zhhbvy463fhkbjyzltzpvocafu 169 5 endothelin endothelin NNP work_zhhbvy463fhkbjyzltzpvocafu 169 6 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 169 7 B b NN work_zhhbvy463fhkbjyzltzpvocafu 169 8 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 169 9 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 169 10 in in IN work_zhhbvy463fhkbjyzltzpvocafu 169 11 Japanese Japanese NNP work_zhhbvy463fhkbjyzltzpvocafu 169 12 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 169 13 ’s ’s POS work_zhhbvy463fhkbjyzltzpvocafu 169 14 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 169 15 . . . work_zhhbvy463fhkbjyzltzpvocafu 170 1 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 170 2 Pediatr Pediatr NNP work_zhhbvy463fhkbjyzltzpvocafu 170 3 Surg Surg NNP work_zhhbvy463fhkbjyzltzpvocafu 170 4 1998;33:1206–8 1998;33:1206–8 CD work_zhhbvy463fhkbjyzltzpvocafu 170 5 . . . work_zhhbvy463fhkbjyzltzpvocafu 171 1 30 30 CD work_zhhbvy463fhkbjyzltzpvocafu 171 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 172 1 Attie Attie NNP work_zhhbvy463fhkbjyzltzpvocafu 172 2 T T NNP work_zhhbvy463fhkbjyzltzpvocafu 172 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 172 4 Till Till NNP work_zhhbvy463fhkbjyzltzpvocafu 172 5 M M NNP work_zhhbvy463fhkbjyzltzpvocafu 172 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 172 7 Pelet Pelet NNP work_zhhbvy463fhkbjyzltzpvocafu 172 8 A A NNP work_zhhbvy463fhkbjyzltzpvocafu 172 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 172 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 172 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 172 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 173 1 Mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 173 2 of of IN work_zhhbvy463fhkbjyzltzpvocafu 173 3 the the DT work_zhhbvy463fhkbjyzltzpvocafu 173 4 endothelin- endothelin- NN work_zhhbvy463fhkbjyzltzpvocafu 173 5 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 173 6 B B NNP work_zhhbvy463fhkbjyzltzpvocafu 173 7 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 173 8 in in IN work_zhhbvy463fhkbjyzltzpvocafu 173 9 Waardenburg Waardenburg NNP work_zhhbvy463fhkbjyzltzpvocafu 173 10 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 173 11 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 173 12 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 173 13 . . . work_zhhbvy463fhkbjyzltzpvocafu 174 1 Hum Hum NNP work_zhhbvy463fhkbjyzltzpvocafu 174 2 Mol Mol NNP work_zhhbvy463fhkbjyzltzpvocafu 174 3 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 174 4 1995;4:2407–9 1995;4:2407–9 CD work_zhhbvy463fhkbjyzltzpvocafu 174 5 . . . work_zhhbvy463fhkbjyzltzpvocafu 175 1 31 31 CD work_zhhbvy463fhkbjyzltzpvocafu 175 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 176 1 Amiel Amiel NNP work_zhhbvy463fhkbjyzltzpvocafu 176 2 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 176 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 176 4 Attie Attie NNP work_zhhbvy463fhkbjyzltzpvocafu 176 5 T T NNP work_zhhbvy463fhkbjyzltzpvocafu 176 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 176 7 Jan Jan NNP work_zhhbvy463fhkbjyzltzpvocafu 176 8 D D NNP work_zhhbvy463fhkbjyzltzpvocafu 176 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 176 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 176 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 176 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 177 1 Heterozygous heterozygous JJ work_zhhbvy463fhkbjyzltzpvocafu 177 2 endothelin endothelin JJ work_zhhbvy463fhkbjyzltzpvocafu 177 3 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 177 4 B B NNP work_zhhbvy463fhkbjyzltzpvocafu 177 5 ( ( -LRB- work_zhhbvy463fhkbjyzltzpvocafu 177 6 EDNRB EDNRB NNP work_zhhbvy463fhkbjyzltzpvocafu 177 7 ) ) -RRB- work_zhhbvy463fhkbjyzltzpvocafu 177 8 mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 177 9 in in IN work_zhhbvy463fhkbjyzltzpvocafu 177 10 isolated isolated JJ work_zhhbvy463fhkbjyzltzpvocafu 177 11 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 177 12 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 177 13 . . . work_zhhbvy463fhkbjyzltzpvocafu 178 1 Hum Hum NNP work_zhhbvy463fhkbjyzltzpvocafu 178 2 Mol Mol NNP work_zhhbvy463fhkbjyzltzpvocafu 178 3 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 178 4 1996;5:355–7 1996;5:355–7 CD work_zhhbvy463fhkbjyzltzpvocafu 178 5 . . . work_zhhbvy463fhkbjyzltzpvocafu 179 1 32 32 CD work_zhhbvy463fhkbjyzltzpvocafu 179 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 180 1 Tanaka Tanaka NNP work_zhhbvy463fhkbjyzltzpvocafu 180 2 H H NNP work_zhhbvy463fhkbjyzltzpvocafu 180 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 180 4 Moroi Moroi NNP work_zhhbvy463fhkbjyzltzpvocafu 180 5 K K NNP work_zhhbvy463fhkbjyzltzpvocafu 180 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 180 7 Iwai Iwai NNP work_zhhbvy463fhkbjyzltzpvocafu 180 8 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 180 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 180 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 180 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 180 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 181 1 Novel novel JJ work_zhhbvy463fhkbjyzltzpvocafu 181 2 mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 181 3 of of IN work_zhhbvy463fhkbjyzltzpvocafu 181 4 the the DT work_zhhbvy463fhkbjyzltzpvocafu 181 5 endothelin endothelin NNP work_zhhbvy463fhkbjyzltzpvocafu 181 6 B B NNP work_zhhbvy463fhkbjyzltzpvocafu 181 7 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 181 8 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 181 9 in in IN work_zhhbvy463fhkbjyzltzpvocafu 181 10 patients patient NNS work_zhhbvy463fhkbjyzltzpvocafu 181 11 with with IN work_zhhbvy463fhkbjyzltzpvocafu 181 12 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 181 13 ’s ’s POS work_zhhbvy463fhkbjyzltzpvocafu 181 14 disease disease NN work_zhhbvy463fhkbjyzltzpvocafu 181 15 and and CC work_zhhbvy463fhkbjyzltzpvocafu 181 16 their -PRON- PRP$ work_zhhbvy463fhkbjyzltzpvocafu 181 17 characterization characterization NN work_zhhbvy463fhkbjyzltzpvocafu 181 18 . . . work_zhhbvy463fhkbjyzltzpvocafu 182 1 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 182 2 Biol Biol NNP work_zhhbvy463fhkbjyzltzpvocafu 182 3 Chem Chem NNP work_zhhbvy463fhkbjyzltzpvocafu 182 4 1998;273 1998;273 CD work_zhhbvy463fhkbjyzltzpvocafu 182 5 : : : work_zhhbvy463fhkbjyzltzpvocafu 182 6 11378–83 11378–83 CD work_zhhbvy463fhkbjyzltzpvocafu 182 7 . . . work_zhhbvy463fhkbjyzltzpvocafu 183 1 33 33 CD work_zhhbvy463fhkbjyzltzpvocafu 183 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 184 1 Sakai Sakai NNP work_zhhbvy463fhkbjyzltzpvocafu 184 2 T T NNP work_zhhbvy463fhkbjyzltzpvocafu 184 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 184 4 Nirasawa Nirasawa NNP work_zhhbvy463fhkbjyzltzpvocafu 184 5 Y Y NNP work_zhhbvy463fhkbjyzltzpvocafu 184 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 184 7 Itoh Itoh NNP work_zhhbvy463fhkbjyzltzpvocafu 184 8 Y Y NNP work_zhhbvy463fhkbjyzltzpvocafu 184 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 184 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 184 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 184 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 185 1 Japanese japanese JJ work_zhhbvy463fhkbjyzltzpvocafu 185 2 patients patient NNS work_zhhbvy463fhkbjyzltzpvocafu 185 3 with with IN work_zhhbvy463fhkbjyzltzpvocafu 185 4 sporadic sporadic JJ work_zhhbvy463fhkbjyzltzpvocafu 185 5 Hirschsprung Hirschsprung NNP work_zhhbvy463fhkbjyzltzpvocafu 185 6 : : : work_zhhbvy463fhkbjyzltzpvocafu 185 7 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 185 8 analysis analysis NN work_zhhbvy463fhkbjyzltzpvocafu 185 9 of of IN work_zhhbvy463fhkbjyzltzpvocafu 185 10 the the DT work_zhhbvy463fhkbjyzltzpvocafu 185 11 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 185 12 tyrosine tyrosine NN work_zhhbvy463fhkbjyzltzpvocafu 185 13 kinase kinase NNP work_zhhbvy463fhkbjyzltzpvocafu 185 14 proto proto NN work_zhhbvy463fhkbjyzltzpvocafu 185 15 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 185 16 oncogene oncogene NNP work_zhhbvy463fhkbjyzltzpvocafu 185 17 , , , work_zhhbvy463fhkbjyzltzpvocafu 185 18 endothelin endothelin NN work_zhhbvy463fhkbjyzltzpvocafu 185 19 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 185 20 B b NN work_zhhbvy463fhkbjyzltzpvocafu 185 21 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 185 22 , , , work_zhhbvy463fhkbjyzltzpvocafu 185 23 endothelin-3 endothelin-3 NNP work_zhhbvy463fhkbjyzltzpvocafu 185 24 , , , work_zhhbvy463fhkbjyzltzpvocafu 185 25 glial glial JJ work_zhhbvy463fhkbjyzltzpvocafu 185 26 cell cell NN work_zhhbvy463fhkbjyzltzpvocafu 185 27 line line NN work_zhhbvy463fhkbjyzltzpvocafu 185 28 - - HYPH work_zhhbvy463fhkbjyzltzpvocafu 185 29 derived derive VBN work_zhhbvy463fhkbjyzltzpvocafu 185 30 neurotrophic neurotrophic JJ work_zhhbvy463fhkbjyzltzpvocafu 185 31 factor factor NN work_zhhbvy463fhkbjyzltzpvocafu 185 32 and and CC work_zhhbvy463fhkbjyzltzpvocafu 185 33 neurturin neurturin NNP work_zhhbvy463fhkbjyzltzpvocafu 185 34 genes gene NNS work_zhhbvy463fhkbjyzltzpvocafu 185 35 : : : work_zhhbvy463fhkbjyzltzpvocafu 185 36 a a DT work_zhhbvy463fhkbjyzltzpvocafu 185 37 comparison comparison NN work_zhhbvy463fhkbjyzltzpvocafu 185 38 with with IN work_zhhbvy463fhkbjyzltzpvocafu 185 39 similar similar JJ work_zhhbvy463fhkbjyzltzpvocafu 185 40 studies study NNS work_zhhbvy463fhkbjyzltzpvocafu 185 41 . . . work_zhhbvy463fhkbjyzltzpvocafu 186 1 Eur Eur NNP work_zhhbvy463fhkbjyzltzpvocafu 186 2 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 186 3 Pediatr Pediatr NNP work_zhhbvy463fhkbjyzltzpvocafu 186 4 2000;159:160–7 2000;159:160–7 NNP work_zhhbvy463fhkbjyzltzpvocafu 186 5 . . . work_zhhbvy463fhkbjyzltzpvocafu 187 1 34 34 CD work_zhhbvy463fhkbjyzltzpvocafu 187 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 188 1 Boardman Boardman NNP work_zhhbvy463fhkbjyzltzpvocafu 188 2 JP JP NNP work_zhhbvy463fhkbjyzltzpvocafu 188 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 188 4 Syrris Syrris NNP work_zhhbvy463fhkbjyzltzpvocafu 188 5 P P NNP work_zhhbvy463fhkbjyzltzpvocafu 188 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 188 7 Holder Holder NNP work_zhhbvy463fhkbjyzltzpvocafu 188 8 SE SE NNP work_zhhbvy463fhkbjyzltzpvocafu 188 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 188 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 188 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 188 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 189 1 A a DT work_zhhbvy463fhkbjyzltzpvocafu 189 2 novel novel JJ work_zhhbvy463fhkbjyzltzpvocafu 189 3 mutation mutation NN work_zhhbvy463fhkbjyzltzpvocafu 189 4 in in IN work_zhhbvy463fhkbjyzltzpvocafu 189 5 the the DT work_zhhbvy463fhkbjyzltzpvocafu 189 6 endothelin endothelin NNP work_zhhbvy463fhkbjyzltzpvocafu 189 7 B B NNP work_zhhbvy463fhkbjyzltzpvocafu 189 8 receptor receptor NN work_zhhbvy463fhkbjyzltzpvocafu 189 9 gene gene NN work_zhhbvy463fhkbjyzltzpvocafu 189 10 in in IN work_zhhbvy463fhkbjyzltzpvocafu 189 11 a a DT work_zhhbvy463fhkbjyzltzpvocafu 189 12 patient patient NN work_zhhbvy463fhkbjyzltzpvocafu 189 13 with with IN work_zhhbvy463fhkbjyzltzpvocafu 189 14 Shah- Shah- NNP work_zhhbvy463fhkbjyzltzpvocafu 189 15 Waardenburg Waardenburg NNP work_zhhbvy463fhkbjyzltzpvocafu 189 16 syndrome syndrome NN work_zhhbvy463fhkbjyzltzpvocafu 189 17 and and CC work_zhhbvy463fhkbjyzltzpvocafu 189 18 Down Down NNP work_zhhbvy463fhkbjyzltzpvocafu 189 19 syndrome syndrome NN work_zhhbvy463fhkbjyzltzpvocafu 189 20 . . . work_zhhbvy463fhkbjyzltzpvocafu 190 1 J J NNP work_zhhbvy463fhkbjyzltzpvocafu 190 2 Med Med NNP work_zhhbvy463fhkbjyzltzpvocafu 190 3 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 190 4 2001;38:646–7 2001;38:646–7 CD work_zhhbvy463fhkbjyzltzpvocafu 190 5 . . . work_zhhbvy463fhkbjyzltzpvocafu 191 1 35 35 CD work_zhhbvy463fhkbjyzltzpvocafu 191 2 . . . work_zhhbvy463fhkbjyzltzpvocafu 192 1 Pingault Pingault NNP work_zhhbvy463fhkbjyzltzpvocafu 192 2 V V NNP work_zhhbvy463fhkbjyzltzpvocafu 192 3 , , , work_zhhbvy463fhkbjyzltzpvocafu 192 4 Girard Girard NNP work_zhhbvy463fhkbjyzltzpvocafu 192 5 M M NNP work_zhhbvy463fhkbjyzltzpvocafu 192 6 , , , work_zhhbvy463fhkbjyzltzpvocafu 192 7 Bondurand Bondurand NNP work_zhhbvy463fhkbjyzltzpvocafu 192 8 N N NNP work_zhhbvy463fhkbjyzltzpvocafu 192 9 , , , work_zhhbvy463fhkbjyzltzpvocafu 192 10 et et NNP work_zhhbvy463fhkbjyzltzpvocafu 192 11 al al NNP work_zhhbvy463fhkbjyzltzpvocafu 192 12 . . . work_zhhbvy463fhkbjyzltzpvocafu 193 1 SOX10 SOX10 NNP work_zhhbvy463fhkbjyzltzpvocafu 193 2 mutations mutation NNS work_zhhbvy463fhkbjyzltzpvocafu 193 3 in in IN work_zhhbvy463fhkbjyzltzpvocafu 193 4 chronic chronic JJ work_zhhbvy463fhkbjyzltzpvocafu 193 5 intestinal intestinal JJ work_zhhbvy463fhkbjyzltzpvocafu 193 6 pseudo pseudo NN work_zhhbvy463fhkbjyzltzpvocafu 193 7 - - NN work_zhhbvy463fhkbjyzltzpvocafu 193 8 obstruction obstruction NN work_zhhbvy463fhkbjyzltzpvocafu 193 9 suggest suggest VBP work_zhhbvy463fhkbjyzltzpvocafu 193 10 a a DT work_zhhbvy463fhkbjyzltzpvocafu 193 11 com- com- NN work_zhhbvy463fhkbjyzltzpvocafu 193 12 plex plex NN work_zhhbvy463fhkbjyzltzpvocafu 193 13 physiopathological physiopathological JJ work_zhhbvy463fhkbjyzltzpvocafu 193 14 mechanism mechanism NN work_zhhbvy463fhkbjyzltzpvocafu 193 15 . . . work_zhhbvy463fhkbjyzltzpvocafu 194 1 Hum Hum NNP work_zhhbvy463fhkbjyzltzpvocafu 194 2 Genet Genet NNP work_zhhbvy463fhkbjyzltzpvocafu 194 3 2002 2002 CD work_zhhbvy463fhkbjyzltzpvocafu 194 4 ; ; : work_zhhbvy463fhkbjyzltzpvocafu 194 5 111:198–206 111:198–206 CD work_zhhbvy463fhkbjyzltzpvocafu 194 6 . . .