id sid tid token lemma pos work_seorv76asvbfzbdykrqsobtgea 1 1 A a DT work_seorv76asvbfzbdykrqsobtgea 1 2 shared share VBN work_seorv76asvbfzbdykrqsobtgea 1 3 founder founder NN work_seorv76asvbfzbdykrqsobtgea 1 4 mutation mutation NN work_seorv76asvbfzbdykrqsobtgea 1 5 underlies underlie VBZ work_seorv76asvbfzbdykrqsobtgea 1 6 lethal lethal JJ work_seorv76asvbfzbdykrqsobtgea 1 7 restrictive restrictive JJ work_seorv76asvbfzbdykrqsobtgea 1 8 dermopathy dermopathy NN work_seorv76asvbfzbdykrqsobtgea 1 9 in in IN work_seorv76asvbfzbdykrqsobtgea 1 10 the the DT work_seorv76asvbfzbdykrqsobtgea 1 11 Austronesian austronesian JJ work_seorv76asvbfzbdykrqsobtgea 1 12 aboriginal aboriginal JJ work_seorv76asvbfzbdykrqsobtgea 1 13 Atayal Atayal NNP work_seorv76asvbfzbdykrqsobtgea 1 14 tribe tribe NN work_seorv76asvbfzbdykrqsobtgea 1 15 of of IN work_seorv76asvbfzbdykrqsobtgea 1 16 Taiwan Taiwan NNP work_seorv76asvbfzbdykrqsobtgea 1 17 Journal Journal NNP work_seorv76asvbfzbdykrqsobtgea 1 18 of of IN work_seorv76asvbfzbdykrqsobtgea 1 19 the the DT work_seorv76asvbfzbdykrqsobtgea 1 20 Formosan Formosan NNP work_seorv76asvbfzbdykrqsobtgea 1 21 Medical Medical NNP work_seorv76asvbfzbdykrqsobtgea 1 22 Association Association NNP work_seorv76asvbfzbdykrqsobtgea 1 23 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 1 24 2015 2015 CD work_seorv76asvbfzbdykrqsobtgea 1 25 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 1 26 114 114 CD work_seorv76asvbfzbdykrqsobtgea 1 27 , , , work_seorv76asvbfzbdykrqsobtgea 1 28 1017e1019 1017e1019 NN work_seorv76asvbfzbdykrqsobtgea 1 29 Available available JJ work_seorv76asvbfzbdykrqsobtgea 1 30 online online RB work_seorv76asvbfzbdykrqsobtgea 1 31 at at IN work_seorv76asvbfzbdykrqsobtgea 1 32 www.sciencedirect.com www.sciencedirect.com ADD work_seorv76asvbfzbdykrqsobtgea 1 33 ScienceDirect ScienceDirect NNP work_seorv76asvbfzbdykrqsobtgea 1 34 journal journal NNP work_seorv76asvbfzbdykrqsobtgea 1 35 homepage homepage NN work_seorv76asvbfzbdykrqsobtgea 1 36 : : : work_seorv76asvbfzbdykrqsobtgea 1 37 www.jfma-online.com www.jfma-online.com ADD work_seorv76asvbfzbdykrqsobtgea 1 38 CORRESPONDENCE CORRESPONDENCE NNP work_seorv76asvbfzbdykrqsobtgea 1 39 A a DT work_seorv76asvbfzbdykrqsobtgea 1 40 shared share VBN work_seorv76asvbfzbdykrqsobtgea 1 41 founder founder NN work_seorv76asvbfzbdykrqsobtgea 1 42 mutation mutation NN work_seorv76asvbfzbdykrqsobtgea 1 43 underlies underlie VBZ work_seorv76asvbfzbdykrqsobtgea 1 44 lethal lethal JJ work_seorv76asvbfzbdykrqsobtgea 1 45 restrictive restrictive JJ work_seorv76asvbfzbdykrqsobtgea 1 46 dermopathy dermopathy NN work_seorv76asvbfzbdykrqsobtgea 1 47 in in IN work_seorv76asvbfzbdykrqsobtgea 1 48 the the DT work_seorv76asvbfzbdykrqsobtgea 1 49 Austronesian austronesian JJ work_seorv76asvbfzbdykrqsobtgea 1 50 aboriginal aboriginal JJ work_seorv76asvbfzbdykrqsobtgea 1 51 Atayal Atayal NNP work_seorv76asvbfzbdykrqsobtgea 1 52 tribe tribe NN work_seorv76asvbfzbdykrqsobtgea 1 53 of of IN work_seorv76asvbfzbdykrqsobtgea 1 54 Taiwan Taiwan NNP work_seorv76asvbfzbdykrqsobtgea 1 55 Jia Jia NNP work_seorv76asvbfzbdykrqsobtgea 1 56 - - HYPH work_seorv76asvbfzbdykrqsobtgea 1 57 Woei Woei NNP work_seorv76asvbfzbdykrqsobtgea 1 58 Hou Hou NNP work_seorv76asvbfzbdykrqsobtgea 1 59 a a NNP work_seorv76asvbfzbdykrqsobtgea 1 60 , , , work_seorv76asvbfzbdykrqsobtgea 1 61 b b NN work_seorv76asvbfzbdykrqsobtgea 1 62 , , , work_seorv76asvbfzbdykrqsobtgea 1 63 * * NFP work_seorv76asvbfzbdykrqsobtgea 1 64 a a DT work_seorv76asvbfzbdykrqsobtgea 1 65 Department Department NNP work_seorv76asvbfzbdykrqsobtgea 1 66 of of IN work_seorv76asvbfzbdykrqsobtgea 1 67 Pediatrics Pediatrics NNPS work_seorv76asvbfzbdykrqsobtgea 1 68 , , , work_seorv76asvbfzbdykrqsobtgea 1 69 Cathay Cathay NNP work_seorv76asvbfzbdykrqsobtgea 1 70 General General NNP work_seorv76asvbfzbdykrqsobtgea 1 71 Hospital Hospital NNP work_seorv76asvbfzbdykrqsobtgea 1 72 , , , work_seorv76asvbfzbdykrqsobtgea 1 73 Taipei Taipei NNP work_seorv76asvbfzbdykrqsobtgea 1 74 , , , work_seorv76asvbfzbdykrqsobtgea 1 75 Taiwan Taiwan NNP work_seorv76asvbfzbdykrqsobtgea 1 76 b b NNP work_seorv76asvbfzbdykrqsobtgea 1 77 College College NNP work_seorv76asvbfzbdykrqsobtgea 1 78 of of IN work_seorv76asvbfzbdykrqsobtgea 1 79 Medicine Medicine NNP work_seorv76asvbfzbdykrqsobtgea 1 80 , , , work_seorv76asvbfzbdykrqsobtgea 1 81 Fu Fu NNP work_seorv76asvbfzbdykrqsobtgea 1 82 - - HYPH work_seorv76asvbfzbdykrqsobtgea 1 83 Jen Jen NNP work_seorv76asvbfzbdykrqsobtgea 1 84 Catholic Catholic NNP work_seorv76asvbfzbdykrqsobtgea 1 85 University University NNP work_seorv76asvbfzbdykrqsobtgea 1 86 , , , work_seorv76asvbfzbdykrqsobtgea 1 87 New New NNP work_seorv76asvbfzbdykrqsobtgea 1 88 Taipei Taipei NNP work_seorv76asvbfzbdykrqsobtgea 1 89 City City NNP work_seorv76asvbfzbdykrqsobtgea 1 90 , , , work_seorv76asvbfzbdykrqsobtgea 1 91 Taiwan Taiwan NNP work_seorv76asvbfzbdykrqsobtgea 1 92 Received receive VBD work_seorv76asvbfzbdykrqsobtgea 1 93 21 21 CD work_seorv76asvbfzbdykrqsobtgea 1 94 February February NNP work_seorv76asvbfzbdykrqsobtgea 1 95 2014 2014 CD work_seorv76asvbfzbdykrqsobtgea 1 96 ; ; : work_seorv76asvbfzbdykrqsobtgea 1 97 received receive VBN work_seorv76asvbfzbdykrqsobtgea 1 98 in in IN work_seorv76asvbfzbdykrqsobtgea 1 99 revised revise VBN work_seorv76asvbfzbdykrqsobtgea 1 100 form form NN work_seorv76asvbfzbdykrqsobtgea 1 101 28 28 CD work_seorv76asvbfzbdykrqsobtgea 1 102 July July NNP work_seorv76asvbfzbdykrqsobtgea 1 103 2014 2014 CD work_seorv76asvbfzbdykrqsobtgea 1 104 ; ; : work_seorv76asvbfzbdykrqsobtgea 1 105 accepted accept VBD work_seorv76asvbfzbdykrqsobtgea 1 106 22 22 CD work_seorv76asvbfzbdykrqsobtgea 1 107 August August NNP work_seorv76asvbfzbdykrqsobtgea 1 108 2014 2014 CD work_seorv76asvbfzbdykrqsobtgea 1 109 Lethal Lethal NNP work_seorv76asvbfzbdykrqsobtgea 1 110 restrictive restrictive JJ work_seorv76asvbfzbdykrqsobtgea 1 111 dermopathy dermopathy NN work_seorv76asvbfzbdykrqsobtgea 1 112 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 1 113 RD RD NNP work_seorv76asvbfzbdykrqsobtgea 1 114 , , , work_seorv76asvbfzbdykrqsobtgea 1 115 OMIM#275210 OMIM#275210 NNP work_seorv76asvbfzbdykrqsobtgea 1 116 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 1 117 belongs belong VBZ work_seorv76asvbfzbdykrqsobtgea 1 118 to to IN work_seorv76asvbfzbdykrqsobtgea 1 119 the the DT work_seorv76asvbfzbdykrqsobtgea 1 120 laminopathies laminopathie NNS work_seorv76asvbfzbdykrqsobtgea 1 121 . . . work_seorv76asvbfzbdykrqsobtgea 2 1 It -PRON- PRP work_seorv76asvbfzbdykrqsobtgea 2 2 is be VBZ work_seorv76asvbfzbdykrqsobtgea 2 3 characterized characterize VBN work_seorv76asvbfzbdykrqsobtgea 2 4 by by IN work_seorv76asvbfzbdykrqsobtgea 2 5 abnormal abnormal JJ work_seorv76asvbfzbdykrqsobtgea 2 6 skin skin NN work_seorv76asvbfzbdykrqsobtgea 2 7 growth growth NN work_seorv76asvbfzbdykrqsobtgea 2 8 and and CC work_seorv76asvbfzbdykrqsobtgea 2 9 differentiation differentiation NN work_seorv76asvbfzbdykrqsobtgea 2 10 and and CC work_seorv76asvbfzbdykrqsobtgea 2 11 is be VBZ work_seorv76asvbfzbdykrqsobtgea 2 12 a a DT work_seorv76asvbfzbdykrqsobtgea 2 13 very very RB work_seorv76asvbfzbdykrqsobtgea 2 14 rare rare JJ work_seorv76asvbfzbdykrqsobtgea 2 15 , , , work_seorv76asvbfzbdykrqsobtgea 2 16 lethal lethal JJ work_seorv76asvbfzbdykrqsobtgea 2 17 gen- gen- NN work_seorv76asvbfzbdykrqsobtgea 2 18 odermatosis odermatosis NN work_seorv76asvbfzbdykrqsobtgea 2 19 . . . work_seorv76asvbfzbdykrqsobtgea 3 1 Since since IN work_seorv76asvbfzbdykrqsobtgea 3 2 the the DT work_seorv76asvbfzbdykrqsobtgea 3 3 cases case NNS work_seorv76asvbfzbdykrqsobtgea 3 4 of of IN work_seorv76asvbfzbdykrqsobtgea 3 5 two two CD work_seorv76asvbfzbdykrqsobtgea 3 6 newborn newborn JJ work_seorv76asvbfzbdykrqsobtgea 3 7 girls girl NNS work_seorv76asvbfzbdykrqsobtgea 3 8 with with IN work_seorv76asvbfzbdykrqsobtgea 3 9 RD RD NNP work_seorv76asvbfzbdykrqsobtgea 3 10 in in IN work_seorv76asvbfzbdykrqsobtgea 3 11 Taiwan Taiwan NNP work_seorv76asvbfzbdykrqsobtgea 3 12 were be VBD work_seorv76asvbfzbdykrqsobtgea 3 13 published publish VBN work_seorv76asvbfzbdykrqsobtgea 3 14 in in IN work_seorv76asvbfzbdykrqsobtgea 3 15 2003,1 2003,1 NNP work_seorv76asvbfzbdykrqsobtgea 3 16 a a DT work_seorv76asvbfzbdykrqsobtgea 3 17 total total NN work_seorv76asvbfzbdykrqsobtgea 3 18 of of IN work_seorv76asvbfzbdykrqsobtgea 3 19 nine nine CD work_seorv76asvbfzbdykrqsobtgea 3 20 Taiwanese taiwanese JJ work_seorv76asvbfzbdykrqsobtgea 3 21 patients patient NNS work_seorv76asvbfzbdykrqsobtgea 3 22 with with IN work_seorv76asvbfzbdykrqsobtgea 3 23 RD RD NNP work_seorv76asvbfzbdykrqsobtgea 3 24 have have VBP work_seorv76asvbfzbdykrqsobtgea 3 25 been be VBN work_seorv76asvbfzbdykrqsobtgea 3 26 described describe VBN work_seorv76asvbfzbdykrqsobtgea 3 27 , , , work_seorv76asvbfzbdykrqsobtgea 3 28 including include VBG work_seorv76asvbfzbdykrqsobtgea 3 29 six six CD work_seorv76asvbfzbdykrqsobtgea 3 30 previously previously RB work_seorv76asvbfzbdykrqsobtgea 3 31 - - HYPH work_seorv76asvbfzbdykrqsobtgea 3 32 reported report VBN work_seorv76asvbfzbdykrqsobtgea 3 33 cases1e4 cases1e4 NNP work_seorv76asvbfzbdykrqsobtgea 3 34 and and CC work_seorv76asvbfzbdykrqsobtgea 3 35 three three CD work_seorv76asvbfzbdykrqsobtgea 3 36 novel novel JJ work_seorv76asvbfzbdykrqsobtgea 3 37 patients patient NNS work_seorv76asvbfzbdykrqsobtgea 3 38 . . . work_seorv76asvbfzbdykrqsobtgea 4 1 The the DT work_seorv76asvbfzbdykrqsobtgea 4 2 diagnosis diagnosis NN work_seorv76asvbfzbdykrqsobtgea 4 3 of of IN work_seorv76asvbfzbdykrqsobtgea 4 4 RD RD NNP work_seorv76asvbfzbdykrqsobtgea 4 5 made make VBN work_seorv76asvbfzbdykrqsobtgea 4 6 was be VBD work_seorv76asvbfzbdykrqsobtgea 4 7 based base VBN work_seorv76asvbfzbdykrqsobtgea 4 8 on on IN work_seorv76asvbfzbdykrqsobtgea 4 9 the the DT work_seorv76asvbfzbdykrqsobtgea 4 10 facial facial JJ work_seorv76asvbfzbdykrqsobtgea 4 11 features feature NNS work_seorv76asvbfzbdykrqsobtgea 4 12 including include VBG work_seorv76asvbfzbdykrqsobtgea 4 13 hypertelorism hypertelorism NN work_seorv76asvbfzbdykrqsobtgea 4 14 , , , work_seorv76asvbfzbdykrqsobtgea 4 15 short short JJ work_seorv76asvbfzbdykrqsobtgea 4 16 , , , work_seorv76asvbfzbdykrqsobtgea 4 17 down- down- JJ work_seorv76asvbfzbdykrqsobtgea 4 18 slanting slant VBG work_seorv76asvbfzbdykrqsobtgea 4 19 palpebral palpebral JJ work_seorv76asvbfzbdykrqsobtgea 4 20 fissures fissure NNS work_seorv76asvbfzbdykrqsobtgea 4 21 , , , work_seorv76asvbfzbdykrqsobtgea 4 22 small small JJ work_seorv76asvbfzbdykrqsobtgea 4 23 , , , work_seorv76asvbfzbdykrqsobtgea 4 24 pinched pinched JJ work_seorv76asvbfzbdykrqsobtgea 4 25 nose nose NN work_seorv76asvbfzbdykrqsobtgea 4 26 , , , work_seorv76asvbfzbdykrqsobtgea 4 27 posteri- posteri- NNP work_seorv76asvbfzbdykrqsobtgea 4 28 orly orly RB work_seorv76asvbfzbdykrqsobtgea 4 29 rotated rotated JJ work_seorv76asvbfzbdykrqsobtgea 4 30 and and CC work_seorv76asvbfzbdykrqsobtgea 4 31 low low JJ work_seorv76asvbfzbdykrqsobtgea 4 32 - - HYPH work_seorv76asvbfzbdykrqsobtgea 4 33 set set NN work_seorv76asvbfzbdykrqsobtgea 4 34 ears ear NNS work_seorv76asvbfzbdykrqsobtgea 4 35 , , , work_seorv76asvbfzbdykrqsobtgea 4 36 micrognathia micrognathia NNP work_seorv76asvbfzbdykrqsobtgea 4 37 , , , work_seorv76asvbfzbdykrqsobtgea 4 38 and and CC work_seorv76asvbfzbdykrqsobtgea 4 39 mouth mouth NN work_seorv76asvbfzbdykrqsobtgea 4 40 fixed fix VBN work_seorv76asvbfzbdykrqsobtgea 4 41 in in IN work_seorv76asvbfzbdykrqsobtgea 4 42 the the DT work_seorv76asvbfzbdykrqsobtgea 4 43 “ " `` work_seorv76asvbfzbdykrqsobtgea 4 44 o o NN work_seorv76asvbfzbdykrqsobtgea 4 45 ” " '' work_seorv76asvbfzbdykrqsobtgea 4 46 position position NN work_seorv76asvbfzbdykrqsobtgea 4 47 , , , work_seorv76asvbfzbdykrqsobtgea 4 48 as as RB work_seorv76asvbfzbdykrqsobtgea 4 49 well well RB work_seorv76asvbfzbdykrqsobtgea 4 50 as as IN work_seorv76asvbfzbdykrqsobtgea 4 51 thin thin JJ work_seorv76asvbfzbdykrqsobtgea 4 52 , , , work_seorv76asvbfzbdykrqsobtgea 4 53 rigid rigid JJ work_seorv76asvbfzbdykrqsobtgea 4 54 and and CC work_seorv76asvbfzbdykrqsobtgea 4 55 tense tense JJ work_seorv76asvbfzbdykrqsobtgea 4 56 skin skin NN work_seorv76asvbfzbdykrqsobtgea 4 57 with with IN work_seorv76asvbfzbdykrqsobtgea 4 58 erosions erosion NNS work_seorv76asvbfzbdykrqsobtgea 4 59 and and CC work_seorv76asvbfzbdykrqsobtgea 4 60 scaling scaling NN work_seorv76asvbfzbdykrqsobtgea 4 61 , , , work_seorv76asvbfzbdykrqsobtgea 4 62 prominent prominent JJ work_seorv76asvbfzbdykrqsobtgea 4 63 skin skin NN work_seorv76asvbfzbdykrqsobtgea 4 64 vessels vessel NNS work_seorv76asvbfzbdykrqsobtgea 4 65 , , , work_seorv76asvbfzbdykrqsobtgea 4 66 multiple multiple JJ work_seorv76asvbfzbdykrqsobtgea 4 67 joint joint JJ work_seorv76asvbfzbdykrqsobtgea 4 68 contractures contracture NNS work_seorv76asvbfzbdykrqsobtgea 4 69 , , , work_seorv76asvbfzbdykrqsobtgea 4 70 absent absent JJ work_seorv76asvbfzbdykrqsobtgea 4 71 or or CC work_seorv76asvbfzbdykrqsobtgea 4 72 small small JJ work_seorv76asvbfzbdykrqsobtgea 4 73 nails nail NNS work_seorv76asvbfzbdykrqsobtgea 4 74 , , , work_seorv76asvbfzbdykrqsobtgea 4 75 rocker- rocker- VBG work_seorv76asvbfzbdykrqsobtgea 4 76 bottom bottom JJ work_seorv76asvbfzbdykrqsobtgea 4 77 feet foot NNS work_seorv76asvbfzbdykrqsobtgea 4 78 , , , work_seorv76asvbfzbdykrqsobtgea 4 79 and and CC work_seorv76asvbfzbdykrqsobtgea 4 80 a a DT work_seorv76asvbfzbdykrqsobtgea 4 81 narrow narrow JJ work_seorv76asvbfzbdykrqsobtgea 4 82 chest chest NN work_seorv76asvbfzbdykrqsobtgea 4 83 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 4 84 Fig fig NN work_seorv76asvbfzbdykrqsobtgea 4 85 . . . work_seorv76asvbfzbdykrqsobtgea 5 1 1A 1a LS work_seorv76asvbfzbdykrqsobtgea 5 2 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 5 3 . . . work_seorv76asvbfzbdykrqsobtgea 6 1 Other other JJ work_seorv76asvbfzbdykrqsobtgea 6 2 perinatal perinatal JJ work_seorv76asvbfzbdykrqsobtgea 6 3 signs sign NNS work_seorv76asvbfzbdykrqsobtgea 6 4 can can MD work_seorv76asvbfzbdykrqsobtgea 6 5 include include VB work_seorv76asvbfzbdykrqsobtgea 6 6 intrauterine intrauterine JJ work_seorv76asvbfzbdykrqsobtgea 6 7 growth growth NN work_seorv76asvbfzbdykrqsobtgea 6 8 retardation retardation NN work_seorv76asvbfzbdykrqsobtgea 6 9 , , , work_seorv76asvbfzbdykrqsobtgea 6 10 poly- poly- NNP work_seorv76asvbfzbdykrqsobtgea 6 11 hydramnios hydramnio NNS work_seorv76asvbfzbdykrqsobtgea 6 12 , , , work_seorv76asvbfzbdykrqsobtgea 6 13 premature premature JJ work_seorv76asvbfzbdykrqsobtgea 6 14 rupture rupture NN work_seorv76asvbfzbdykrqsobtgea 6 15 of of IN work_seorv76asvbfzbdykrqsobtgea 6 16 the the DT work_seorv76asvbfzbdykrqsobtgea 6 17 membranes membrane NNS work_seorv76asvbfzbdykrqsobtgea 6 18 with with IN work_seorv76asvbfzbdykrqsobtgea 6 19 subsequent subsequent JJ work_seorv76asvbfzbdykrqsobtgea 6 20 delivery delivery NN work_seorv76asvbfzbdykrqsobtgea 6 21 at at IN work_seorv76asvbfzbdykrqsobtgea 6 22 about about IN work_seorv76asvbfzbdykrqsobtgea 6 23 30e32 30e32 NNP work_seorv76asvbfzbdykrqsobtgea 6 24 weeks week NNS work_seorv76asvbfzbdykrqsobtgea 6 25 of of IN work_seorv76asvbfzbdykrqsobtgea 6 26 gestation gestation NN work_seorv76asvbfzbdykrqsobtgea 6 27 , , , work_seorv76asvbfzbdykrqsobtgea 6 28 large large JJ work_seorv76asvbfzbdykrqsobtgea 6 29 placentas placenta NNS work_seorv76asvbfzbdykrqsobtgea 6 30 , , , work_seorv76asvbfzbdykrqsobtgea 6 31 neonatal neonatal JJ work_seorv76asvbfzbdykrqsobtgea 6 32 teeth tooth NNS work_seorv76asvbfzbdykrqsobtgea 6 33 , , , work_seorv76asvbfzbdykrqsobtgea 6 34 and and CC work_seorv76asvbfzbdykrqsobtgea 6 35 pulmonary pulmonary JJ work_seorv76asvbfzbdykrqsobtgea 6 36 hypopla- hypopla- NN work_seorv76asvbfzbdykrqsobtgea 6 37 sia sia NN work_seorv76asvbfzbdykrqsobtgea 6 38 leading lead VBG work_seorv76asvbfzbdykrqsobtgea 6 39 to to IN work_seorv76asvbfzbdykrqsobtgea 6 40 respiratory respiratory JJ work_seorv76asvbfzbdykrqsobtgea 6 41 insufficiency.1e4 insufficiency.1e4 NNP work_seorv76asvbfzbdykrqsobtgea 6 42 RD RD NNP work_seorv76asvbfzbdykrqsobtgea 6 43 should should MD work_seorv76asvbfzbdykrqsobtgea 6 44 be be VB work_seorv76asvbfzbdykrqsobtgea 6 45 Conflicts conflict NNS work_seorv76asvbfzbdykrqsobtgea 6 46 of of IN work_seorv76asvbfzbdykrqsobtgea 6 47 interest interest NN work_seorv76asvbfzbdykrqsobtgea 6 48 : : : work_seorv76asvbfzbdykrqsobtgea 6 49 The the DT work_seorv76asvbfzbdykrqsobtgea 6 50 author author NN work_seorv76asvbfzbdykrqsobtgea 6 51 has have VBZ work_seorv76asvbfzbdykrqsobtgea 6 52 no no DT work_seorv76asvbfzbdykrqsobtgea 6 53 conflicts conflict NNS work_seorv76asvbfzbdykrqsobtgea 6 54 of of IN work_seorv76asvbfzbdykrqsobtgea 6 55 interest interest NN work_seorv76asvbfzbdykrqsobtgea 6 56 relevant relevant JJ work_seorv76asvbfzbdykrqsobtgea 6 57 to to IN work_seorv76asvbfzbdykrqsobtgea 6 58 this this DT work_seorv76asvbfzbdykrqsobtgea 6 59 article article NN work_seorv76asvbfzbdykrqsobtgea 6 60 . . . work_seorv76asvbfzbdykrqsobtgea 7 1 * * NFP work_seorv76asvbfzbdykrqsobtgea 7 2 Corresponding correspond VBG work_seorv76asvbfzbdykrqsobtgea 7 3 author author NN work_seorv76asvbfzbdykrqsobtgea 7 4 . . . work_seorv76asvbfzbdykrqsobtgea 8 1 Department Department NNP work_seorv76asvbfzbdykrqsobtgea 8 2 of of IN work_seorv76asvbfzbdykrqsobtgea 8 3 Pediatrics Pediatrics NNPS work_seorv76asvbfzbdykrqsobtgea 8 4 , , , work_seorv76asvbfzbdykrqsobtgea 8 5 Cathay Cathay NNP work_seorv76asvbfzbdykrqsobtgea 8 6 Gen- Gen- NNP work_seorv76asvbfzbdykrqsobtgea 8 7 eral eral NNP work_seorv76asvbfzbdykrqsobtgea 8 8 Hospital Hospital NNP work_seorv76asvbfzbdykrqsobtgea 8 9 , , , work_seorv76asvbfzbdykrqsobtgea 8 10 280 280 CD work_seorv76asvbfzbdykrqsobtgea 8 11 Sec Sec NNP work_seorv76asvbfzbdykrqsobtgea 8 12 4 4 CD work_seorv76asvbfzbdykrqsobtgea 8 13 Jen Jen NNP work_seorv76asvbfzbdykrqsobtgea 8 14 - - HYPH work_seorv76asvbfzbdykrqsobtgea 8 15 Ai Ai NNP work_seorv76asvbfzbdykrqsobtgea 8 16 Road Road NNP work_seorv76asvbfzbdykrqsobtgea 8 17 , , , work_seorv76asvbfzbdykrqsobtgea 8 18 Taipei Taipei NNP work_seorv76asvbfzbdykrqsobtgea 8 19 106 106 CD work_seorv76asvbfzbdykrqsobtgea 8 20 , , , work_seorv76asvbfzbdykrqsobtgea 8 21 Taiwan Taiwan NNP work_seorv76asvbfzbdykrqsobtgea 8 22 . . . work_seorv76asvbfzbdykrqsobtgea 9 1 E e NN work_seorv76asvbfzbdykrqsobtgea 9 2 - - NN work_seorv76asvbfzbdykrqsobtgea 9 3 mail mail NN work_seorv76asvbfzbdykrqsobtgea 9 4 address address NN work_seorv76asvbfzbdykrqsobtgea 9 5 : : : work_seorv76asvbfzbdykrqsobtgea 9 6 hou76@cgh.org.tw hou76@cgh.org.tw RB work_seorv76asvbfzbdykrqsobtgea 9 7 . . . work_seorv76asvbfzbdykrqsobtgea 10 1 http://dx.doi.org/10.1016/j.jfma.2014.08.007 http://dx.doi.org/10.1016/j.jfma.2014.08.007 DT work_seorv76asvbfzbdykrqsobtgea 10 2 0929 0929 CD work_seorv76asvbfzbdykrqsobtgea 10 3 - - SYM work_seorv76asvbfzbdykrqsobtgea 10 4 6646 6646 CD work_seorv76asvbfzbdykrqsobtgea 10 5 / / SYM work_seorv76asvbfzbdykrqsobtgea 10 6 Copyright Copyright NNP work_seorv76asvbfzbdykrqsobtgea 10 7 ª ª NNP work_seorv76asvbfzbdykrqsobtgea 10 8 2014 2014 CD work_seorv76asvbfzbdykrqsobtgea 10 9 , , , work_seorv76asvbfzbdykrqsobtgea 10 10 Elsevier Elsevier NNP work_seorv76asvbfzbdykrqsobtgea 10 11 Taiwan Taiwan NNP work_seorv76asvbfzbdykrqsobtgea 10 12 LLC LLC NNP work_seorv76asvbfzbdykrqsobtgea 10 13 & & CC work_seorv76asvbfzbdykrqsobtgea 10 14 Formosan Formosan NNP work_seorv76asvbfzbdykrqsobtgea 10 15 Medical Medical NNP work_seorv76asvbfzbdykrqsobtgea 10 16 differentiated differentiate VBD work_seorv76asvbfzbdykrqsobtgea 10 17 from from IN work_seorv76asvbfzbdykrqsobtgea 10 18 other other JJ work_seorv76asvbfzbdykrqsobtgea 10 19 diseases disease NNS work_seorv76asvbfzbdykrqsobtgea 10 20 and and CC work_seorv76asvbfzbdykrqsobtgea 10 21 syndromes syndrome NNS work_seorv76asvbfzbdykrqsobtgea 10 22 , , , work_seorv76asvbfzbdykrqsobtgea 10 23 including include VBG work_seorv76asvbfzbdykrqsobtgea 10 24 Hutchinson Hutchinson NNP work_seorv76asvbfzbdykrqsobtgea 10 25 - - HYPH work_seorv76asvbfzbdykrqsobtgea 10 26 Gilford Gilford NNP work_seorv76asvbfzbdykrqsobtgea 10 27 progeria progeria NN work_seorv76asvbfzbdykrqsobtgea 10 28 , , , work_seorv76asvbfzbdykrqsobtgea 10 29 generalized generalize VBD work_seorv76asvbfzbdykrqsobtgea 10 30 scleroderma scleroderma NNP work_seorv76asvbfzbdykrqsobtgea 10 31 , , , work_seorv76asvbfzbdykrqsobtgea 10 32 collodion collodion NN work_seorv76asvbfzbdykrqsobtgea 10 33 or or CC work_seorv76asvbfzbdykrqsobtgea 10 34 harlequin harlequin NN work_seorv76asvbfzbdykrqsobtgea 10 35 baby baby NN work_seorv76asvbfzbdykrqsobtgea 10 36 , , , work_seorv76asvbfzbdykrqsobtgea 10 37 Pena Pena NNP work_seorv76asvbfzbdykrqsobtgea 10 38 - - HYPH work_seorv76asvbfzbdykrqsobtgea 10 39 Shokeir Shokeir NNP work_seorv76asvbfzbdykrqsobtgea 10 40 , , , work_seorv76asvbfzbdykrqsobtgea 10 41 and and CC work_seorv76asvbfzbdykrqsobtgea 10 42 Neu Neu NNP work_seorv76asvbfzbdykrqsobtgea 10 43 - - HYPH work_seorv76asvbfzbdykrqsobtgea 10 44 Laxova Laxova NNP work_seorv76asvbfzbdykrqsobtgea 10 45 syndromes syndrome VBZ work_seorv76asvbfzbdykrqsobtgea 10 46 . . . work_seorv76asvbfzbdykrqsobtgea 11 1 The the DT work_seorv76asvbfzbdykrqsobtgea 11 2 characteristic characteristic JJ work_seorv76asvbfzbdykrqsobtgea 11 3 facies facie NNS work_seorv76asvbfzbdykrqsobtgea 11 4 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 11 5 after after IN work_seorv76asvbfzbdykrqsobtgea 11 6 extreme extreme JJ work_seorv76asvbfzbdykrqsobtgea 11 7 tautness tautness NN work_seorv76asvbfzbdykrqsobtgea 11 8 of of IN work_seorv76asvbfzbdykrqsobtgea 11 9 the the DT work_seorv76asvbfzbdykrqsobtgea 11 10 skin skin NN work_seorv76asvbfzbdykrqsobtgea 11 11 in in IN work_seorv76asvbfzbdykrqsobtgea 11 12 utero utero NNS work_seorv76asvbfzbdykrqsobtgea 11 13 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 11 14 , , , work_seorv76asvbfzbdykrqsobtgea 11 15 absence absence NN work_seorv76asvbfzbdykrqsobtgea 11 16 of of IN work_seorv76asvbfzbdykrqsobtgea 11 17 neurological neurological JJ work_seorv76asvbfzbdykrqsobtgea 11 18 abnormalities abnormality NNS work_seorv76asvbfzbdykrqsobtgea 11 19 , , , work_seorv76asvbfzbdykrqsobtgea 11 20 differences difference NNS work_seorv76asvbfzbdykrqsobtgea 11 21 in in IN work_seorv76asvbfzbdykrqsobtgea 11 22 clinical clinical JJ work_seorv76asvbfzbdykrqsobtgea 11 23 course course NN work_seorv76asvbfzbdykrqsobtgea 11 24 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 11 25 lethal lethal JJ work_seorv76asvbfzbdykrqsobtgea 11 26 outcome outcome NN work_seorv76asvbfzbdykrqsobtgea 11 27 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 11 28 , , , work_seorv76asvbfzbdykrqsobtgea 11 29 and and CC work_seorv76asvbfzbdykrqsobtgea 11 30 unique unique JJ work_seorv76asvbfzbdykrqsobtgea 11 31 histopathological histopathological JJ work_seorv76asvbfzbdykrqsobtgea 11 32 findings finding NNS work_seorv76asvbfzbdykrqsobtgea 11 33 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 11 34 near near JJ work_seorv76asvbfzbdykrqsobtgea 11 35 - - HYPH work_seorv76asvbfzbdykrqsobtgea 11 36 absence absence NN work_seorv76asvbfzbdykrqsobtgea 11 37 of of IN work_seorv76asvbfzbdykrqsobtgea 11 38 the the DT work_seorv76asvbfzbdykrqsobtgea 11 39 dermal dermal JJ work_seorv76asvbfzbdykrqsobtgea 11 40 elastic elastic JJ work_seorv76asvbfzbdykrqsobtgea 11 41 fibers fiber NNS work_seorv76asvbfzbdykrqsobtgea 11 42 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 11 43 could could MD work_seorv76asvbfzbdykrqsobtgea 11 44 distin- distin- VB work_seorv76asvbfzbdykrqsobtgea 11 45 guish guish VB work_seorv76asvbfzbdykrqsobtgea 11 46 RD RD NNP work_seorv76asvbfzbdykrqsobtgea 11 47 from from IN work_seorv76asvbfzbdykrqsobtgea 11 48 the the DT work_seorv76asvbfzbdykrqsobtgea 11 49 other other JJ work_seorv76asvbfzbdykrqsobtgea 11 50 diseases disease NNS work_seorv76asvbfzbdykrqsobtgea 11 51 mentioned mention VBN work_seorv76asvbfzbdykrqsobtgea 11 52 . . . work_seorv76asvbfzbdykrqsobtgea 12 1 These these DT work_seorv76asvbfzbdykrqsobtgea 12 2 RD RD NNP work_seorv76asvbfzbdykrqsobtgea 12 3 patients patient NNS work_seorv76asvbfzbdykrqsobtgea 12 4 are be VBP work_seorv76asvbfzbdykrqsobtgea 12 5 all all RB work_seorv76asvbfzbdykrqsobtgea 12 6 from from IN work_seorv76asvbfzbdykrqsobtgea 12 7 seven seven CD work_seorv76asvbfzbdykrqsobtgea 12 8 different different JJ work_seorv76asvbfzbdykrqsobtgea 12 9 Atayal Atayal NNP work_seorv76asvbfzbdykrqsobtgea 12 10 families family NNS work_seorv76asvbfzbdykrqsobtgea 12 11 , , , work_seorv76asvbfzbdykrqsobtgea 12 12 with with IN work_seorv76asvbfzbdykrqsobtgea 12 13 a a DT work_seorv76asvbfzbdykrqsobtgea 12 14 male male NN work_seorv76asvbfzbdykrqsobtgea 12 15 - - HYPH work_seorv76asvbfzbdykrqsobtgea 12 16 to to IN work_seorv76asvbfzbdykrqsobtgea 12 17 - - HYPH work_seorv76asvbfzbdykrqsobtgea 12 18 female female JJ work_seorv76asvbfzbdykrqsobtgea 12 19 ratio ratio NN work_seorv76asvbfzbdykrqsobtgea 12 20 of of IN work_seorv76asvbfzbdykrqsobtgea 12 21 5:4 5:4 CD work_seorv76asvbfzbdykrqsobtgea 12 22 , , , work_seorv76asvbfzbdykrqsobtgea 12 23 and and CC work_seorv76asvbfzbdykrqsobtgea 12 24 the the DT work_seorv76asvbfzbdykrqsobtgea 12 25 babies baby NNS work_seorv76asvbfzbdykrqsobtgea 12 26 died die VBD work_seorv76asvbfzbdykrqsobtgea 12 27 between between IN work_seorv76asvbfzbdykrqsobtgea 12 28 birth birth NN work_seorv76asvbfzbdykrqsobtgea 12 29 and and CC work_seorv76asvbfzbdykrqsobtgea 12 30 75 75 CD work_seorv76asvbfzbdykrqsobtgea 12 31 days day NNS work_seorv76asvbfzbdykrqsobtgea 12 32 post post NN work_seorv76asvbfzbdykrqsobtgea 12 33 - - JJ work_seorv76asvbfzbdykrqsobtgea 12 34 partum partum NN work_seorv76asvbfzbdykrqsobtgea 12 35 . . . work_seorv76asvbfzbdykrqsobtgea 13 1 Recurrent recurrent JJ work_seorv76asvbfzbdykrqsobtgea 13 2 abortions abortion NNS work_seorv76asvbfzbdykrqsobtgea 13 3 were be VBD work_seorv76asvbfzbdykrqsobtgea 13 4 found find VBN work_seorv76asvbfzbdykrqsobtgea 13 5 in in IN work_seorv76asvbfzbdykrqsobtgea 13 6 five five CD work_seorv76asvbfzbdykrqsobtgea 13 7 pairs pair NNS work_seorv76asvbfzbdykrqsobtgea 13 8 of of IN work_seorv76asvbfzbdykrqsobtgea 13 9 parents parent NNS work_seorv76asvbfzbdykrqsobtgea 13 10 . . . work_seorv76asvbfzbdykrqsobtgea 14 1 Clinical clinical JJ work_seorv76asvbfzbdykrqsobtgea 14 2 in- in- JJ work_seorv76asvbfzbdykrqsobtgea 14 3 formation formation NN work_seorv76asvbfzbdykrqsobtgea 14 4 was be VBD work_seorv76asvbfzbdykrqsobtgea 14 5 collected collect VBN work_seorv76asvbfzbdykrqsobtgea 14 6 from from IN work_seorv76asvbfzbdykrqsobtgea 14 7 their -PRON- PRP$ work_seorv76asvbfzbdykrqsobtgea 14 8 medical medical JJ work_seorv76asvbfzbdykrqsobtgea 14 9 records record NNS work_seorv76asvbfzbdykrqsobtgea 14 10 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 14 11 Pa- pa- NN work_seorv76asvbfzbdykrqsobtgea 14 12 tients tient VBZ work_seorv76asvbfzbdykrqsobtgea 14 13 1e8 1e8 CD work_seorv76asvbfzbdykrqsobtgea 14 14 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 14 15 and and CC work_seorv76asvbfzbdykrqsobtgea 14 16 the the DT work_seorv76asvbfzbdykrqsobtgea 14 17 reported report VBN work_seorv76asvbfzbdykrqsobtgea 14 18 papers paper NNS work_seorv76asvbfzbdykrqsobtgea 14 19 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 14 20 patients patient NNS work_seorv76asvbfzbdykrqsobtgea 14 21 1e5 1e5 CD work_seorv76asvbfzbdykrqsobtgea 14 22 , , , work_seorv76asvbfzbdykrqsobtgea 14 23 9).1e4 9).1e4 CD work_seorv76asvbfzbdykrqsobtgea 14 24 Decreased decreased JJ work_seorv76asvbfzbdykrqsobtgea 14 25 levels level NNS work_seorv76asvbfzbdykrqsobtgea 14 26 of of IN work_seorv76asvbfzbdykrqsobtgea 14 27 serum serum NN work_seorv76asvbfzbdykrqsobtgea 14 28 albumin albumin NNP work_seorv76asvbfzbdykrqsobtgea 14 29 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 14 30 5e7 5e7 NNP work_seorv76asvbfzbdykrqsobtgea 14 31 g g NNP work_seorv76asvbfzbdykrqsobtgea 14 32 / / SYM work_seorv76asvbfzbdykrqsobtgea 14 33 dL dL NNP work_seorv76asvbfzbdykrqsobtgea 14 34 , , , work_seorv76asvbfzbdykrqsobtgea 14 35 2.3e3.4 2.3e3.4 CD work_seorv76asvbfzbdykrqsobtgea 14 36 g/ g/ NNP work_seorv76asvbfzbdykrqsobtgea 14 37 dL dL NNP work_seorv76asvbfzbdykrqsobtgea 14 38 ; ; : work_seorv76asvbfzbdykrqsobtgea 14 39 reference reference NN work_seorv76asvbfzbdykrqsobtgea 14 40 range range NN work_seorv76asvbfzbdykrqsobtgea 14 41 of of IN work_seorv76asvbfzbdykrqsobtgea 14 42 3.9e5.0 3.9e5.0 NNPS work_seorv76asvbfzbdykrqsobtgea 14 43 g g NNP work_seorv76asvbfzbdykrqsobtgea 14 44 / / SYM work_seorv76asvbfzbdykrqsobtgea 14 45 dL dL NNP work_seorv76asvbfzbdykrqsobtgea 14 46 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 14 47 , , , work_seorv76asvbfzbdykrqsobtgea 14 48 and and CC work_seorv76asvbfzbdykrqsobtgea 14 49 cholestasis cholestasis NN work_seorv76asvbfzbdykrqsobtgea 14 50 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 14 51 Pa- Pa- NNP work_seorv76asvbfzbdykrqsobtgea 14 52 tient tient NN work_seorv76asvbfzbdykrqsobtgea 14 53 6 6 CD work_seorv76asvbfzbdykrqsobtgea 14 54 and and CC work_seorv76asvbfzbdykrqsobtgea 14 55 Patient Patient NNP work_seorv76asvbfzbdykrqsobtgea 14 56 7 7 CD work_seorv76asvbfzbdykrqsobtgea 14 57 , , , work_seorv76asvbfzbdykrqsobtgea 14 58 peak peak VB work_seorv76asvbfzbdykrqsobtgea 14 59 total total NN work_seorv76asvbfzbdykrqsobtgea 14 60 / / SYM work_seorv76asvbfzbdykrqsobtgea 14 61 direct direct JJ work_seorv76asvbfzbdykrqsobtgea 14 62 bilirubin bilirubin NN work_seorv76asvbfzbdykrqsobtgea 14 63 at at IN work_seorv76asvbfzbdykrqsobtgea 14 64 1 1 CD work_seorv76asvbfzbdykrqsobtgea 14 65 month month NN work_seorv76asvbfzbdykrqsobtgea 14 66 : : : work_seorv76asvbfzbdykrqsobtgea 14 67 7.8/3.5 7.8/3.5 CD work_seorv76asvbfzbdykrqsobtgea 14 68 mg mg NNP work_seorv76asvbfzbdykrqsobtgea 14 69 / / SYM work_seorv76asvbfzbdykrqsobtgea 14 70 dL dL NNP work_seorv76asvbfzbdykrqsobtgea 14 71 and and CC work_seorv76asvbfzbdykrqsobtgea 14 72 5.2/3.1 5.2/3.1 CD work_seorv76asvbfzbdykrqsobtgea 14 73 mg mg NNP work_seorv76asvbfzbdykrqsobtgea 14 74 / / SYM work_seorv76asvbfzbdykrqsobtgea 14 75 dL dL NNP work_seorv76asvbfzbdykrqsobtgea 14 76 , , , work_seorv76asvbfzbdykrqsobtgea 14 77 respectively respectively RB work_seorv76asvbfzbdykrqsobtgea 14 78 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 14 79 were be VBD work_seorv76asvbfzbdykrqsobtgea 14 80 noted note VBN work_seorv76asvbfzbdykrqsobtgea 14 81 . . . work_seorv76asvbfzbdykrqsobtgea 15 1 Urine urine NN work_seorv76asvbfzbdykrqsobtgea 15 2 gas gas NN work_seorv76asvbfzbdykrqsobtgea 15 3 chromatography chromatography NN work_seorv76asvbfzbdykrqsobtgea 15 4 / / SYM work_seorv76asvbfzbdykrqsobtgea 15 5 mass mass NNP work_seorv76asvbfzbdykrqsobtgea 15 6 spectrometry spectrometry NN work_seorv76asvbfzbdykrqsobtgea 15 7 studies study NNS work_seorv76asvbfzbdykrqsobtgea 15 8 showed show VBD work_seorv76asvbfzbdykrqsobtgea 15 9 N N NNP work_seorv76asvbfzbdykrqsobtgea 15 10 - - HYPH work_seorv76asvbfzbdykrqsobtgea 15 11 acetyl acetyl NNP work_seorv76asvbfzbdykrqsobtgea 15 12 tyrosinuria tyrosinuria NN work_seorv76asvbfzbdykrqsobtgea 15 13 and and CC work_seorv76asvbfzbdykrqsobtgea 15 14 generalized generalize VBD work_seorv76asvbfzbdykrqsobtgea 15 15 organic organic JJ work_seorv76asvbfzbdykrqsobtgea 15 16 aciduria aciduria NNP work_seorv76asvbfzbdykrqsobtgea 15 17 with with IN work_seorv76asvbfzbdykrqsobtgea 15 18 lactic lactic JJ work_seorv76asvbfzbdykrqsobtgea 15 19 ketoaciduria ketoaciduria NNP work_seorv76asvbfzbdykrqsobtgea 15 20 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 15 21 Patient Patient NNP work_seorv76asvbfzbdykrqsobtgea 15 22 5 5 CD work_seorv76asvbfzbdykrqsobtgea 15 23 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 15 24 ; ; : work_seorv76asvbfzbdykrqsobtgea 15 25 and and CC work_seorv76asvbfzbdykrqsobtgea 15 26 generalized generalize VBD work_seorv76asvbfzbdykrqsobtgea 15 27 organic organic JJ work_seorv76asvbfzbdykrqsobtgea 15 28 aciduria aciduria NN work_seorv76asvbfzbdykrqsobtgea 15 29 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 15 30 Patient Patient NNP work_seorv76asvbfzbdykrqsobtgea 15 31 6 6 CD work_seorv76asvbfzbdykrqsobtgea 15 32 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 15 33 . . . work_seorv76asvbfzbdykrqsobtgea 16 1 Tandem Tandem NNP work_seorv76asvbfzbdykrqsobtgea 16 2 mass mass NN work_seorv76asvbfzbdykrqsobtgea 16 3 spectrometry spectrometry NN work_seorv76asvbfzbdykrqsobtgea 16 4 showed show VBD work_seorv76asvbfzbdykrqsobtgea 16 5 diffusely diffusely RB work_seorv76asvbfzbdykrqsobtgea 16 6 low low JJ work_seorv76asvbfzbdykrqsobtgea 16 7 levels level NNS work_seorv76asvbfzbdykrqsobtgea 16 8 of of IN work_seorv76asvbfzbdykrqsobtgea 16 9 amino amino JJ work_seorv76asvbfzbdykrqsobtgea 16 10 acids acid NNS work_seorv76asvbfzbdykrqsobtgea 16 11 , , , work_seorv76asvbfzbdykrqsobtgea 16 12 free free JJ work_seorv76asvbfzbdykrqsobtgea 16 13 carnitine carnitine NN work_seorv76asvbfzbdykrqsobtgea 16 14 and and CC work_seorv76asvbfzbdykrqsobtgea 16 15 fatty fatty NN work_seorv76asvbfzbdykrqsobtgea 16 16 acids acid NNS work_seorv76asvbfzbdykrqsobtgea 16 17 in in IN work_seorv76asvbfzbdykrqsobtgea 16 18 patients patient NNS work_seorv76asvbfzbdykrqsobtgea 16 19 5e8 5e8 CD work_seorv76asvbfzbdykrqsobtgea 16 20 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 16 21 except except IN work_seorv76asvbfzbdykrqsobtgea 16 22 for for IN work_seorv76asvbfzbdykrqsobtgea 16 23 high high JJ work_seorv76asvbfzbdykrqsobtgea 16 24 isovaleryl isovaleryl NN work_seorv76asvbfzbdykrqsobtgea 16 25 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 16 26 C5 c5 NN work_seorv76asvbfzbdykrqsobtgea 16 27 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 16 28 carnitine carnitine NN work_seorv76asvbfzbdykrqsobtgea 16 29 in in IN work_seorv76asvbfzbdykrqsobtgea 16 30 patient patient NNP work_seorv76asvbfzbdykrqsobtgea 16 31 6 6 CD work_seorv76asvbfzbdykrqsobtgea 16 32 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 16 33 . . . work_seorv76asvbfzbdykrqsobtgea 17 1 These these DT work_seorv76asvbfzbdykrqsobtgea 17 2 metabolic metabolic JJ work_seorv76asvbfzbdykrqsobtgea 17 3 findings finding NNS work_seorv76asvbfzbdykrqsobtgea 17 4 might may MD work_seorv76asvbfzbdykrqsobtgea 17 5 be be VB work_seorv76asvbfzbdykrqsobtgea 17 6 secondary secondary JJ work_seorv76asvbfzbdykrqsobtgea 17 7 either either RB work_seorv76asvbfzbdykrqsobtgea 17 8 to to IN work_seorv76asvbfzbdykrqsobtgea 17 9 systemic systemic JJ work_seorv76asvbfzbdykrqsobtgea 17 10 disease disease NN work_seorv76asvbfzbdykrqsobtgea 17 11 or or CC work_seorv76asvbfzbdykrqsobtgea 17 12 liver liver NN work_seorv76asvbfzbdykrqsobtgea 17 13 function function NN work_seorv76asvbfzbdykrqsobtgea 17 14 impairment impairment NN work_seorv76asvbfzbdykrqsobtgea 17 15 , , , work_seorv76asvbfzbdykrqsobtgea 17 16 and and CC work_seorv76asvbfzbdykrqsobtgea 17 17 moreover moreover RB work_seorv76asvbfzbdykrqsobtgea 17 18 originate originate VB work_seorv76asvbfzbdykrqsobtgea 17 19 primar- primar- XX work_seorv76asvbfzbdykrqsobtgea 17 20 ily ily NNP work_seorv76asvbfzbdykrqsobtgea 17 21 from from IN work_seorv76asvbfzbdykrqsobtgea 17 22 RD RD NNP work_seorv76asvbfzbdykrqsobtgea 17 23 itself -PRON- PRP work_seorv76asvbfzbdykrqsobtgea 17 24 . . . work_seorv76asvbfzbdykrqsobtgea 18 1 Association Association NNP work_seorv76asvbfzbdykrqsobtgea 18 2 . . . work_seorv76asvbfzbdykrqsobtgea 19 1 All all DT work_seorv76asvbfzbdykrqsobtgea 19 2 rights right NNS work_seorv76asvbfzbdykrqsobtgea 19 3 reserved reserve VBD work_seorv76asvbfzbdykrqsobtgea 19 4 . . . work_seorv76asvbfzbdykrqsobtgea 20 1 mailto:hou76@cgh.org.tw mailto:hou76@cgh.org.tw NNP work_seorv76asvbfzbdykrqsobtgea 20 2 http://crossmark.crossref.org/dialog/?doi=10.1016/j.jfma.2014.08.007&domain=pdf http://crossmark.crossref.org/dialog/?doi=10.1016/j.jfma.2014.08.007&domain=pdf NNP work_seorv76asvbfzbdykrqsobtgea 20 3 http://dx.doi.org/10.1016/j.jfma.2014.08.007 http://dx.doi.org/10.1016/j.jfma.2014.08.007 VBP work_seorv76asvbfzbdykrqsobtgea 20 4 www.sciencedirect.com/science/journal/09296646 www.sciencedirect.com/science/journal/09296646 UH work_seorv76asvbfzbdykrqsobtgea 20 5 http://www.jfma-online.com http://www.jfma-online.com NNP work_seorv76asvbfzbdykrqsobtgea 20 6 http://dx.doi.org/10.1016/j.jfma.2014.08.007 http://dx.doi.org/10.1016/j.jfma.2014.08.007 FW work_seorv76asvbfzbdykrqsobtgea 20 7 http://dx.doi.org/10.1016/j.jfma.2014.08.007 http://dx.doi.org/10.1016/j.jfma.2014.08.007 UH work_seorv76asvbfzbdykrqsobtgea 20 8 1018 1018 CD work_seorv76asvbfzbdykrqsobtgea 20 9 J.-W. J.-W. NNP work_seorv76asvbfzbdykrqsobtgea 20 10 Hou Hou NNP work_seorv76asvbfzbdykrqsobtgea 20 11 Chromosome Chromosome NNP work_seorv76asvbfzbdykrqsobtgea 20 12 studies study NNS work_seorv76asvbfzbdykrqsobtgea 20 13 from from IN work_seorv76asvbfzbdykrqsobtgea 20 14 amniocytes amniocyte NNS work_seorv76asvbfzbdykrqsobtgea 20 15 or or CC work_seorv76asvbfzbdykrqsobtgea 20 16 peripheral peripheral JJ work_seorv76asvbfzbdykrqsobtgea 20 17 blood blood NN work_seorv76asvbfzbdykrqsobtgea 20 18 showed show VBD work_seorv76asvbfzbdykrqsobtgea 20 19 normal normal JJ work_seorv76asvbfzbdykrqsobtgea 20 20 findings finding NNS work_seorv76asvbfzbdykrqsobtgea 20 21 in in IN work_seorv76asvbfzbdykrqsobtgea 20 22 Patients Patients NNP work_seorv76asvbfzbdykrqsobtgea 20 23 1e8 1e8 CD work_seorv76asvbfzbdykrqsobtgea 20 24 . . . work_seorv76asvbfzbdykrqsobtgea 21 1 Breakage breakage NN work_seorv76asvbfzbdykrqsobtgea 21 2 tests test NNS work_seorv76asvbfzbdykrqsobtgea 21 3 with with IN work_seorv76asvbfzbdykrqsobtgea 21 4 mitomycin mitomycin NNS work_seorv76asvbfzbdykrqsobtgea 21 5 C C NNP work_seorv76asvbfzbdykrqsobtgea 21 6 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 21 7 40 40 CD work_seorv76asvbfzbdykrqsobtgea 21 8 ng ng NN work_seorv76asvbfzbdykrqsobtgea 21 9 / / SYM work_seorv76asvbfzbdykrqsobtgea 21 10 mL ml NN work_seorv76asvbfzbdykrqsobtgea 21 11 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 21 12 showed show VBD work_seorv76asvbfzbdykrqsobtgea 21 13 increased increase VBN work_seorv76asvbfzbdykrqsobtgea 21 14 breakage breakage NN work_seorv76asvbfzbdykrqsobtgea 21 15 rates rate NNS work_seorv76asvbfzbdykrqsobtgea 21 16 in in IN work_seorv76asvbfzbdykrqsobtgea 21 17 Patients patient NNS work_seorv76asvbfzbdykrqsobtgea 21 18 1e8 1e8 CD work_seorv76asvbfzbdykrqsobtgea 21 19 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 21 20 control control NN work_seorv76asvbfzbdykrqsobtgea 21 21 0.6e6.0 0.6e6.0 CD work_seorv76asvbfzbdykrqsobtgea 21 22 % % NN work_seorv76asvbfzbdykrqsobtgea 21 23 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 21 24 : : : work_seorv76asvbfzbdykrqsobtgea 21 25 Pa- pa- JJ work_seorv76asvbfzbdykrqsobtgea 21 26 tient tient NN work_seorv76asvbfzbdykrqsobtgea 21 27 7 7 CD work_seorv76asvbfzbdykrqsobtgea 21 28 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 21 29 157 157 CD work_seorv76asvbfzbdykrqsobtgea 21 30 % % NN work_seorv76asvbfzbdykrqsobtgea 21 31 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 21 32 , , , work_seorv76asvbfzbdykrqsobtgea 21 33 Patient Patient NNP work_seorv76asvbfzbdykrqsobtgea 21 34 8 8 CD work_seorv76asvbfzbdykrqsobtgea 21 35 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 21 36 144 144 CD work_seorv76asvbfzbdykrqsobtgea 21 37 % % NN work_seorv76asvbfzbdykrqsobtgea 21 38 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 21 39 , , , work_seorv76asvbfzbdykrqsobtgea 21 40 Patient Patient NNP work_seorv76asvbfzbdykrqsobtgea 21 41 1 1 CD work_seorv76asvbfzbdykrqsobtgea 21 42 , , , work_seorv76asvbfzbdykrqsobtgea 21 43 Patient Patient NNP work_seorv76asvbfzbdykrqsobtgea 21 44 2 2 CD work_seorv76asvbfzbdykrqsobtgea 21 45 , , , work_seorv76asvbfzbdykrqsobtgea 21 46 Patient Patient NNP work_seorv76asvbfzbdykrqsobtgea 21 47 5 5 CD work_seorv76asvbfzbdykrqsobtgea 21 48 , , , work_seorv76asvbfzbdykrqsobtgea 21 49 and and CC work_seorv76asvbfzbdykrqsobtgea 21 50 Patient Patient NNP work_seorv76asvbfzbdykrqsobtgea 21 51 6 6 CD work_seorv76asvbfzbdykrqsobtgea 21 52 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 21 53 100e121 100e121 CD work_seorv76asvbfzbdykrqsobtgea 21 54 % % NN work_seorv76asvbfzbdykrqsobtgea 21 55 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 21 56 , , , work_seorv76asvbfzbdykrqsobtgea 21 57 and and CC work_seorv76asvbfzbdykrqsobtgea 21 58 Patient Patient NNP work_seorv76asvbfzbdykrqsobtgea 21 59 3 3 CD work_seorv76asvbfzbdykrqsobtgea 21 60 and and CC work_seorv76asvbfzbdykrqsobtgea 21 61 Patient Patient NNP work_seorv76asvbfzbdykrqsobtgea 21 62 4 4 CD work_seorv76asvbfzbdykrqsobtgea 21 63 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 21 64 90e97 90e97 CD work_seorv76asvbfzbdykrqsobtgea 21 65 % % NN work_seorv76asvbfzbdykrqsobtgea 21 66 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 21 67 . . . work_seorv76asvbfzbdykrqsobtgea 22 1 Markedly markedly RB work_seorv76asvbfzbdykrqsobtgea 22 2 increased increase VBN work_seorv76asvbfzbdykrqsobtgea 22 3 breakage breakage NN work_seorv76asvbfzbdykrqsobtgea 22 4 rates rate NNS work_seorv76asvbfzbdykrqsobtgea 22 5 were be VBD work_seorv76asvbfzbdykrqsobtgea 22 6 noted note VBN work_seorv76asvbfzbdykrqsobtgea 22 7 in in IN work_seorv76asvbfzbdykrqsobtgea 22 8 all all DT work_seorv76asvbfzbdykrqsobtgea 22 9 patients patient NNS work_seorv76asvbfzbdykrqsobtgea 22 10 undergoing undergo VBG work_seorv76asvbfzbdykrqsobtgea 22 11 examination examination NN work_seorv76asvbfzbdykrqsobtgea 22 12 . . . work_seorv76asvbfzbdykrqsobtgea 23 1 The the DT work_seorv76asvbfzbdykrqsobtgea 23 2 features feature NNS work_seorv76asvbfzbdykrqsobtgea 23 3 of of IN work_seorv76asvbfzbdykrqsobtgea 23 4 premature premature JJ work_seorv76asvbfzbdykrqsobtgea 23 5 aging aging NN work_seorv76asvbfzbdykrqsobtgea 23 6 in in IN work_seorv76asvbfzbdykrqsobtgea 23 7 RD RD NNP work_seorv76asvbfzbdykrqsobtgea 23 8 or or CC work_seorv76asvbfzbdykrqsobtgea 23 9 other other JJ work_seorv76asvbfzbdykrqsobtgea 23 10 laminopathies laminopathie NNS work_seorv76asvbfzbdykrqsobtgea 23 11 are be VBP work_seorv76asvbfzbdykrqsobtgea 23 12 linked link VBN work_seorv76asvbfzbdykrqsobtgea 23 13 to to IN work_seorv76asvbfzbdykrqsobtgea 23 14 the the DT work_seorv76asvbfzbdykrqsobtgea 23 15 accumulation accumulation NN work_seorv76asvbfzbdykrqsobtgea 23 16 of of IN work_seorv76asvbfzbdykrqsobtgea 23 17 DNA DNA NNP work_seorv76asvbfzbdykrqsobtgea 23 18 double double JJ work_seorv76asvbfzbdykrqsobtgea 23 19 - - HYPH work_seorv76asvbfzbdykrqsobtgea 23 20 strand strand NN work_seorv76asvbfzbdykrqsobtgea 23 21 breaks break NNS work_seorv76asvbfzbdykrqsobtgea 23 22 , , , work_seorv76asvbfzbdykrqsobtgea 23 23 which which WDT work_seorv76asvbfzbdykrqsobtgea 23 24 may may MD work_seorv76asvbfzbdykrqsobtgea 23 25 result result VB work_seorv76asvbfzbdykrqsobtgea 23 26 in in IN work_seorv76asvbfzbdykrqsobtgea 23 27 genome genome JJ work_seorv76asvbfzbdykrqsobtgea 23 28 and and CC work_seorv76asvbfzbdykrqsobtgea 23 29 chromosomal chromosomal JJ work_seorv76asvbfzbdykrqsobtgea 23 30 instability instability NN work_seorv76asvbfzbdykrqsobtgea 23 31 . . . work_seorv76asvbfzbdykrqsobtgea 24 1 Molecular molecular JJ work_seorv76asvbfzbdykrqsobtgea 24 2 studies study NNS work_seorv76asvbfzbdykrqsobtgea 24 3 were be VBD work_seorv76asvbfzbdykrqsobtgea 24 4 performed perform VBN work_seorv76asvbfzbdykrqsobtgea 24 5 on on IN work_seorv76asvbfzbdykrqsobtgea 24 6 the the DT work_seorv76asvbfzbdykrqsobtgea 24 7 genes gene NNS work_seorv76asvbfzbdykrqsobtgea 24 8 encoding encode VBG work_seorv76asvbfzbdykrqsobtgea 24 9 for for IN work_seorv76asvbfzbdykrqsobtgea 24 10 lamins lamin NNS work_seorv76asvbfzbdykrqsobtgea 24 11 A A NNP work_seorv76asvbfzbdykrqsobtgea 24 12 and and CC work_seorv76asvbfzbdykrqsobtgea 24 13 C C NNP work_seorv76asvbfzbdykrqsobtgea 24 14 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 24 15 LMNA LMNA NNP work_seorv76asvbfzbdykrqsobtgea 24 16 , , , work_seorv76asvbfzbdykrqsobtgea 24 17 12 12 CD work_seorv76asvbfzbdykrqsobtgea 24 18 exons exon NNS work_seorv76asvbfzbdykrqsobtgea 24 19 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 24 20 , , , work_seorv76asvbfzbdykrqsobtgea 24 21 and and CC work_seorv76asvbfzbdykrqsobtgea 24 22 all all DT work_seorv76asvbfzbdykrqsobtgea 24 23 10 10 CD work_seorv76asvbfzbdykrqsobtgea 24 24 exons exon NNS work_seorv76asvbfzbdykrqsobtgea 24 25 and and CC work_seorv76asvbfzbdykrqsobtgea 24 26 splice splice NN work_seorv76asvbfzbdykrqsobtgea 24 27 sites site NNS work_seorv76asvbfzbdykrqsobtgea 24 28 of of IN work_seorv76asvbfzbdykrqsobtgea 24 29 the the DT work_seorv76asvbfzbdykrqsobtgea 24 30 ZMPSTE24 ZMPSTE24 NNP work_seorv76asvbfzbdykrqsobtgea 24 31 gene gene NN work_seorv76asvbfzbdykrqsobtgea 24 32 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 24 33 encoding encode VBG work_seorv76asvbfzbdykrqsobtgea 24 34 a a DT work_seorv76asvbfzbdykrqsobtgea 24 35 zinc zinc NN work_seorv76asvbfzbdykrqsobtgea 24 36 metalloproteinase metalloproteinase NN work_seorv76asvbfzbdykrqsobtgea 24 37 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 24 38 . . . work_seorv76asvbfzbdykrqsobtgea 25 1 No no DT work_seorv76asvbfzbdykrqsobtgea 25 2 disease disease NN work_seorv76asvbfzbdykrqsobtgea 25 3 - - HYPH work_seorv76asvbfzbdykrqsobtgea 25 4 causing cause VBG work_seorv76asvbfzbdykrqsobtgea 25 5 mutations mutation NNS work_seorv76asvbfzbdykrqsobtgea 25 6 were be VBD work_seorv76asvbfzbdykrqsobtgea 25 7 observed observe VBN work_seorv76asvbfzbdykrqsobtgea 25 8 in in IN work_seorv76asvbfzbdykrqsobtgea 25 9 LMNA LMNA NNP work_seorv76asvbfzbdykrqsobtgea 25 10 , , , work_seorv76asvbfzbdykrqsobtgea 25 11 while while IN work_seorv76asvbfzbdykrqsobtgea 25 12 a a DT work_seorv76asvbfzbdykrqsobtgea 25 13 disease- disease- JJ work_seorv76asvbfzbdykrqsobtgea 25 14 causing cause VBG work_seorv76asvbfzbdykrqsobtgea 25 15 homozygous homozygous JJ work_seorv76asvbfzbdykrqsobtgea 25 16 stop stop NN work_seorv76asvbfzbdykrqsobtgea 25 17 codon codon NNP work_seorv76asvbfzbdykrqsobtgea 25 18 TAA TAA NNP work_seorv76asvbfzbdykrqsobtgea 25 19 on on IN work_seorv76asvbfzbdykrqsobtgea 25 20 exon exon JJ work_seorv76asvbfzbdykrqsobtgea 25 21 6 6 CD work_seorv76asvbfzbdykrqsobtgea 25 22 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 25 23 c.715 c.715 NN work_seorv76asvbfzbdykrqsobtgea 25 24 G g NN work_seorv76asvbfzbdykrqsobtgea 25 25 > > XX work_seorv76asvbfzbdykrqsobtgea 25 26 T t NN work_seorv76asvbfzbdykrqsobtgea 25 27 , , , work_seorv76asvbfzbdykrqsobtgea 25 28 p p NN work_seorv76asvbfzbdykrqsobtgea 25 29 . . . work_seorv76asvbfzbdykrqsobtgea 25 30 E239X E239X NNP work_seorv76asvbfzbdykrqsobtgea 25 31 , , , work_seorv76asvbfzbdykrqsobtgea 25 32 Fig Fig NNP work_seorv76asvbfzbdykrqsobtgea 25 33 . . . work_seorv76asvbfzbdykrqsobtgea 26 1 1B 1B NNP work_seorv76asvbfzbdykrqsobtgea 26 2 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 26 3 was be VBD work_seorv76asvbfzbdykrqsobtgea 26 4 noted note VBN work_seorv76asvbfzbdykrqsobtgea 26 5 in in IN work_seorv76asvbfzbdykrqsobtgea 26 6 all all DT work_seorv76asvbfzbdykrqsobtgea 26 7 patients patient NNS work_seorv76asvbfzbdykrqsobtgea 26 8 . . . work_seorv76asvbfzbdykrqsobtgea 27 1 All all PDT work_seorv76asvbfzbdykrqsobtgea 27 2 the the DT work_seorv76asvbfzbdykrqsobtgea 27 3 parents parent NNS work_seorv76asvbfzbdykrqsobtgea 27 4 were be VBD work_seorv76asvbfzbdykrqsobtgea 27 5 found find VBN work_seorv76asvbfzbdykrqsobtgea 27 6 to to TO work_seorv76asvbfzbdykrqsobtgea 27 7 be be VB work_seorv76asvbfzbdykrqsobtgea 27 8 heterozygous heterozygous JJ work_seorv76asvbfzbdykrqsobtgea 27 9 carriers carrier NNS work_seorv76asvbfzbdykrqsobtgea 27 10 from from IN work_seorv76asvbfzbdykrqsobtgea 27 11 the the DT work_seorv76asvbfzbdykrqsobtgea 27 12 Atayal Atayal NNP work_seorv76asvbfzbdykrqsobtgea 27 13 tribe tribe NN work_seorv76asvbfzbdykrqsobtgea 27 14 . . . work_seorv76asvbfzbdykrqsobtgea 28 1 RD RD NNP work_seorv76asvbfzbdykrqsobtgea 28 2 can can MD work_seorv76asvbfzbdykrqsobtgea 28 3 be be VB work_seorv76asvbfzbdykrqsobtgea 28 4 caused cause VBN work_seorv76asvbfzbdykrqsobtgea 28 5 by by IN work_seorv76asvbfzbdykrqsobtgea 28 6 dominant dominant JJ work_seorv76asvbfzbdykrqsobtgea 28 7 mutations mutation NNS work_seorv76asvbfzbdykrqsobtgea 28 8 of of IN work_seorv76asvbfzbdykrqsobtgea 28 9 the the DT work_seorv76asvbfzbdykrqsobtgea 28 10 LMNA LMNA NNP work_seorv76asvbfzbdykrqsobtgea 28 11 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 28 12 primary primary JJ work_seorv76asvbfzbdykrqsobtgea 28 13 laminopathy laminopathy NN work_seorv76asvbfzbdykrqsobtgea 28 14 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 28 15 or or CC work_seorv76asvbfzbdykrqsobtgea 28 16 , , , work_seorv76asvbfzbdykrqsobtgea 28 17 more more RBR work_seorv76asvbfzbdykrqsobtgea 28 18 frequently frequently RB work_seorv76asvbfzbdykrqsobtgea 28 19 , , , work_seorv76asvbfzbdykrqsobtgea 28 20 recessive recessive JJ work_seorv76asvbfzbdykrqsobtgea 28 21 mu- mu- NN work_seorv76asvbfzbdykrqsobtgea 28 22 tations tation NNS work_seorv76asvbfzbdykrqsobtgea 28 23 of of IN work_seorv76asvbfzbdykrqsobtgea 28 24 the the DT work_seorv76asvbfzbdykrqsobtgea 28 25 ZMPSTE24 ZMPSTE24 NNP work_seorv76asvbfzbdykrqsobtgea 28 26 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 28 27 secondary secondary JJ work_seorv76asvbfzbdykrqsobtgea 28 28 laminopathy laminopathy JJ work_seorv76asvbfzbdykrqsobtgea 28 29 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 28 30 genes gene NNS work_seorv76asvbfzbdykrqsobtgea 28 31 . . . work_seorv76asvbfzbdykrqsobtgea 29 1 Defects defect NNS work_seorv76asvbfzbdykrqsobtgea 29 2 in in IN work_seorv76asvbfzbdykrqsobtgea 29 3 the the DT work_seorv76asvbfzbdykrqsobtgea 29 4 ZMPSTE24 ZMPSTE24 NNP work_seorv76asvbfzbdykrqsobtgea 29 5 gene gene NN work_seorv76asvbfzbdykrqsobtgea 29 6 may may MD work_seorv76asvbfzbdykrqsobtgea 29 7 impair impair VB work_seorv76asvbfzbdykrqsobtgea 29 8 the the DT work_seorv76asvbfzbdykrqsobtgea 29 9 processing processing NN work_seorv76asvbfzbdykrqsobtgea 29 10 of of IN work_seorv76asvbfzbdykrqsobtgea 29 11 prelamin prelamin NN work_seorv76asvbfzbdykrqsobtgea 29 12 A A NNP work_seorv76asvbfzbdykrqsobtgea 29 13 into into IN work_seorv76asvbfzbdykrqsobtgea 29 14 mature mature JJ work_seorv76asvbfzbdykrqsobtgea 29 15 lamin lamin NN work_seorv76asvbfzbdykrqsobtgea 29 16 A a NN work_seorv76asvbfzbdykrqsobtgea 29 17 , , , work_seorv76asvbfzbdykrqsobtgea 29 18 leading lead VBG work_seorv76asvbfzbdykrqsobtgea 29 19 to to IN work_seorv76asvbfzbdykrqsobtgea 29 20 the the DT work_seorv76asvbfzbdykrqsobtgea 29 21 develop- develop- JJ work_seorv76asvbfzbdykrqsobtgea 29 22 ment ment NN work_seorv76asvbfzbdykrqsobtgea 29 23 of of IN work_seorv76asvbfzbdykrqsobtgea 29 24 RD RD NNP work_seorv76asvbfzbdykrqsobtgea 29 25 . . . work_seorv76asvbfzbdykrqsobtgea 30 1 These these DT work_seorv76asvbfzbdykrqsobtgea 30 2 patients patient NNS work_seorv76asvbfzbdykrqsobtgea 30 3 presented present VBD work_seorv76asvbfzbdykrqsobtgea 30 4 different different JJ work_seorv76asvbfzbdykrqsobtgea 30 5 intra- intra- JJ work_seorv76asvbfzbdykrqsobtgea 30 6 and and CC work_seorv76asvbfzbdykrqsobtgea 30 7 interfamilial interfamilial JJ work_seorv76asvbfzbdykrqsobtgea 30 8 expressivity expressivity NN work_seorv76asvbfzbdykrqsobtgea 30 9 or or CC work_seorv76asvbfzbdykrqsobtgea 30 10 severity severity NN work_seorv76asvbfzbdykrqsobtgea 30 11 , , , work_seorv76asvbfzbdykrqsobtgea 30 12 but but CC work_seorv76asvbfzbdykrqsobtgea 30 13 no no DT work_seorv76asvbfzbdykrqsobtgea 30 14 good good JJ work_seorv76asvbfzbdykrqsobtgea 30 15 genoty- genoty- JJ work_seorv76asvbfzbdykrqsobtgea 30 16 peephenotype peephenotype NN work_seorv76asvbfzbdykrqsobtgea 30 17 correlation correlation NN work_seorv76asvbfzbdykrqsobtgea 30 18 exists exist VBZ work_seorv76asvbfzbdykrqsobtgea 30 19 . . . work_seorv76asvbfzbdykrqsobtgea 31 1 Some some DT work_seorv76asvbfzbdykrqsobtgea 31 2 patients patient NNS work_seorv76asvbfzbdykrqsobtgea 31 3 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 31 4 Patients patient NNS work_seorv76asvbfzbdykrqsobtgea 31 5 5e7 5e7 CD work_seorv76asvbfzbdykrqsobtgea 31 6 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 31 7 lived live VBD work_seorv76asvbfzbdykrqsobtgea 31 8 up up IN work_seorv76asvbfzbdykrqsobtgea 31 9 to to IN work_seorv76asvbfzbdykrqsobtgea 31 10 1e2.5 1e2.5 CD work_seorv76asvbfzbdykrqsobtgea 31 11 months month NNS work_seorv76asvbfzbdykrqsobtgea 31 12 , , , work_seorv76asvbfzbdykrqsobtgea 31 13 suggesting suggest VBG work_seorv76asvbfzbdykrqsobtgea 31 14 some some DT work_seorv76asvbfzbdykrqsobtgea 31 15 residual residual JJ work_seorv76asvbfzbdykrqsobtgea 31 16 function function NN work_seorv76asvbfzbdykrqsobtgea 31 17 of of IN work_seorv76asvbfzbdykrqsobtgea 31 18 the the DT work_seorv76asvbfzbdykrqsobtgea 31 19 mutant mutant JJ work_seorv76asvbfzbdykrqsobtgea 31 20 protein protein NN work_seorv76asvbfzbdykrqsobtgea 31 21 . . . work_seorv76asvbfzbdykrqsobtgea 32 1 Recent recent JJ work_seorv76asvbfzbdykrqsobtgea 32 2 studies study NNS work_seorv76asvbfzbdykrqsobtgea 32 3 have have VBP work_seorv76asvbfzbdykrqsobtgea 32 4 shown show VBN work_seorv76asvbfzbdykrqsobtgea 32 5 that that IN work_seorv76asvbfzbdykrqsobtgea 32 6 the the DT work_seorv76asvbfzbdykrqsobtgea 32 7 frequency frequency NN work_seorv76asvbfzbdykrqsobtgea 32 8 of of IN work_seorv76asvbfzbdykrqsobtgea 32 9 misshapen misshapen JJ work_seorv76asvbfzbdykrqsobtgea 32 10 nuclei nucleus NNS work_seorv76asvbfzbdykrqsobtgea 32 11 can can MD work_seorv76asvbfzbdykrqsobtgea 32 12 be be VB work_seorv76asvbfzbdykrqsobtgea 32 13 reduced reduce VBN work_seorv76asvbfzbdykrqsobtgea 32 14 by by IN work_seorv76asvbfzbdykrqsobtgea 32 15 treating treat VBG work_seorv76asvbfzbdykrqsobtgea 32 16 cells cell NNS work_seorv76asvbfzbdykrqsobtgea 32 17 with with IN work_seorv76asvbfzbdykrqsobtgea 32 18 a a DT work_seorv76asvbfzbdykrqsobtgea 32 19 farnesyltransferase farnesyltransferase NN work_seorv76asvbfzbdykrqsobtgea 32 20 inhibitor inhibitor NN work_seorv76asvbfzbdykrqsobtgea 32 21 . . . work_seorv76asvbfzbdykrqsobtgea 33 1 Removal removal NN work_seorv76asvbfzbdykrqsobtgea 33 2 of of IN work_seorv76asvbfzbdykrqsobtgea 33 3 unprocessed unprocessed JJ work_seorv76asvbfzbdykrqsobtgea 33 4 prelamin prelamin NN work_seorv76asvbfzbdykrqsobtgea 33 5 A a DT work_seorv76asvbfzbdykrqsobtgea 33 6 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 33 7 progerin progerin NN work_seorv76asvbfzbdykrqsobtgea 33 8 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 33 9 or or CC work_seorv76asvbfzbdykrqsobtgea 33 10 rescue rescue NN work_seorv76asvbfzbdykrqsobtgea 33 11 of of IN work_seorv76asvbfzbdykrqsobtgea 33 12 defective defective JJ work_seorv76asvbfzbdykrqsobtgea 33 13 DNA dna NN work_seorv76asvbfzbdykrqsobtgea 33 14 repair repair NN work_seorv76asvbfzbdykrqsobtgea 33 15 could could MD work_seorv76asvbfzbdykrqsobtgea 33 16 be be VB work_seorv76asvbfzbdykrqsobtgea 33 17 potential potential JJ work_seorv76asvbfzbdykrqsobtgea 33 18 therapeutic therapeutic JJ work_seorv76asvbfzbdykrqsobtgea 33 19 strategies strategy NNS work_seorv76asvbfzbdykrqsobtgea 33 20 for for IN work_seorv76asvbfzbdykrqsobtgea 33 21 the the DT work_seorv76asvbfzbdykrqsobtgea 33 22 treatment treatment NN work_seorv76asvbfzbdykrqsobtgea 33 23 of of IN work_seorv76asvbfzbdykrqsobtgea 33 24 HutchinsoneGilford HutchinsoneGilford NNP work_seorv76asvbfzbdykrqsobtgea 33 25 progeria progeria JJ work_seorv76asvbfzbdykrqsobtgea 33 26 syndrome syndrome NN work_seorv76asvbfzbdykrqsobtgea 33 27 or or CC work_seorv76asvbfzbdykrqsobtgea 33 28 RD rd NN work_seorv76asvbfzbdykrqsobtgea 33 29 in in IN work_seorv76asvbfzbdykrqsobtgea 33 30 the the DT work_seorv76asvbfzbdykrqsobtgea 33 31 future future NN work_seorv76asvbfzbdykrqsobtgea 33 32 . . . work_seorv76asvbfzbdykrqsobtgea 34 1 The the DT work_seorv76asvbfzbdykrqsobtgea 34 2 shared shared JJ work_seorv76asvbfzbdykrqsobtgea 34 3 , , , work_seorv76asvbfzbdykrqsobtgea 34 4 common common JJ work_seorv76asvbfzbdykrqsobtgea 34 5 mutation mutation NN work_seorv76asvbfzbdykrqsobtgea 34 6 c.715 c.715 NN work_seorv76asvbfzbdykrqsobtgea 34 7 G g NN work_seorv76asvbfzbdykrqsobtgea 34 8 > > XX work_seorv76asvbfzbdykrqsobtgea 34 9 T t NN work_seorv76asvbfzbdykrqsobtgea 34 10 in in IN work_seorv76asvbfzbdykrqsobtgea 34 11 ZMPSTE24 ZMPSTE24 NNP work_seorv76asvbfzbdykrqsobtgea 34 12 may may MD work_seorv76asvbfzbdykrqsobtgea 34 13 reveal reveal VB work_seorv76asvbfzbdykrqsobtgea 34 14 a a DT work_seorv76asvbfzbdykrqsobtgea 34 15 founder founder NN work_seorv76asvbfzbdykrqsobtgea 34 16 mutation mutation NN work_seorv76asvbfzbdykrqsobtgea 34 17 in in IN work_seorv76asvbfzbdykrqsobtgea 34 18 the the DT work_seorv76asvbfzbdykrqsobtgea 34 19 Austronesian austronesian JJ work_seorv76asvbfzbdykrqsobtgea 34 20 aboriginal aboriginal JJ work_seorv76asvbfzbdykrqsobtgea 34 21 Atayal Atayal NNP work_seorv76asvbfzbdykrqsobtgea 34 22 population population NN work_seorv76asvbfzbdykrqsobtgea 34 23 residing reside VBG work_seorv76asvbfzbdykrqsobtgea 34 24 in in IN work_seorv76asvbfzbdykrqsobtgea 34 25 the the DT work_seorv76asvbfzbdykrqsobtgea 34 26 northern northern JJ work_seorv76asvbfzbdykrqsobtgea 34 27 part part NN work_seorv76asvbfzbdykrqsobtgea 34 28 of of IN work_seorv76asvbfzbdykrqsobtgea 34 29 Taiwan Taiwan NNP work_seorv76asvbfzbdykrqsobtgea 34 30 ’s ’s POS work_seorv76asvbfzbdykrqsobtgea 34 31 Central Central NNP work_seorv76asvbfzbdykrqsobtgea 34 32 Mountain Mountain NNP work_seorv76asvbfzbdykrqsobtgea 34 33 areas area NNS work_seorv76asvbfzbdykrqsobtgea 34 34 . . . work_seorv76asvbfzbdykrqsobtgea 35 1 As as IN work_seorv76asvbfzbdykrqsobtgea 35 2 an an DT work_seorv76asvbfzbdykrqsobtgea 35 3 autosomal autosomal JJ work_seorv76asvbfzbdykrqsobtgea 35 4 recessive recessive JJ work_seorv76asvbfzbdykrqsobtgea 35 5 disorder disorder NN work_seorv76asvbfzbdykrqsobtgea 35 6 , , , work_seorv76asvbfzbdykrqsobtgea 35 7 RD RD NNP work_seorv76asvbfzbdykrqsobtgea 35 8 with with IN work_seorv76asvbfzbdykrqsobtgea 35 9 ZMPSTE24 ZMPSTE24 NNP work_seorv76asvbfzbdykrqsobtgea 35 10 mutation mutation NN work_seorv76asvbfzbdykrqsobtgea 35 11 may may MD work_seorv76asvbfzbdykrqsobtgea 35 12 be be VB work_seorv76asvbfzbdykrqsobtgea 35 13 more more RBR work_seorv76asvbfzbdykrqsobtgea 35 14 preva- preva- JJ work_seorv76asvbfzbdykrqsobtgea 35 15 lent lend VBN work_seorv76asvbfzbdykrqsobtgea 35 16 in in IN work_seorv76asvbfzbdykrqsobtgea 35 17 selected select VBN work_seorv76asvbfzbdykrqsobtgea 35 18 inbred inbreed VBD work_seorv76asvbfzbdykrqsobtgea 35 19 populations population NNS work_seorv76asvbfzbdykrqsobtgea 35 20 with with IN work_seorv76asvbfzbdykrqsobtgea 35 21 a a DT work_seorv76asvbfzbdykrqsobtgea 35 22 high high JJ work_seorv76asvbfzbdykrqsobtgea 35 23 frequency frequency NN work_seorv76asvbfzbdykrqsobtgea 35 24 of of IN work_seorv76asvbfzbdykrqsobtgea 35 25 consanguinity consanguinity NN work_seorv76asvbfzbdykrqsobtgea 35 26 . . . work_seorv76asvbfzbdykrqsobtgea 36 1 Certain certain JJ work_seorv76asvbfzbdykrqsobtgea 36 2 ethnicities ethnicity NNS work_seorv76asvbfzbdykrqsobtgea 36 3 have have VBP work_seorv76asvbfzbdykrqsobtgea 36 4 demonstrated demonstrate VBN work_seorv76asvbfzbdykrqsobtgea 36 5 a a DT work_seorv76asvbfzbdykrqsobtgea 36 6 higher high JJR work_seorv76asvbfzbdykrqsobtgea 36 7 incidence incidence NN work_seorv76asvbfzbdykrqsobtgea 36 8 with with IN work_seorv76asvbfzbdykrqsobtgea 36 9 common common JJ work_seorv76asvbfzbdykrqsobtgea 36 10 mutations mutation NNS work_seorv76asvbfzbdykrqsobtgea 36 11 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 36 12 c.1085dupT c.1085dupT NNP work_seorv76asvbfzbdykrqsobtgea 36 13 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 36 14 due due IN work_seorv76asvbfzbdykrqsobtgea 36 15 to to IN work_seorv76asvbfzbdykrqsobtgea 36 16 endogamous endogamous JJ work_seorv76asvbfzbdykrqsobtgea 36 17 practices practice NNS work_seorv76asvbfzbdykrqsobtgea 36 18 , , , work_seorv76asvbfzbdykrqsobtgea 36 19 such such JJ work_seorv76asvbfzbdykrqsobtgea 36 20 as as IN work_seorv76asvbfzbdykrqsobtgea 36 21 Ashkenazi Ashkenazi NNP work_seorv76asvbfzbdykrqsobtgea 36 22 Jews Jews NNPS work_seorv76asvbfzbdykrqsobtgea 36 23 and and CC work_seorv76asvbfzbdykrqsobtgea 36 24 Mennonites Mennonites NNPS work_seorv76asvbfzbdykrqsobtgea 36 25 , , , work_seorv76asvbfzbdykrqsobtgea 36 26 possibly possibly RB work_seorv76asvbfzbdykrqsobtgea 36 27 attributable attributable JJ work_seorv76asvbfzbdykrqsobtgea 36 28 to to IN work_seorv76asvbfzbdykrqsobtgea 36 29 a a DT work_seorv76asvbfzbdykrqsobtgea 36 30 founder founder NN work_seorv76asvbfzbdykrqsobtgea 36 31 effect.5 effect.5 IN work_seorv76asvbfzbdykrqsobtgea 36 32 Although although IN work_seorv76asvbfzbdykrqsobtgea 36 33 the the DT work_seorv76asvbfzbdykrqsobtgea 36 34 Taiwanese taiwanese JJ work_seorv76asvbfzbdykrqsobtgea 36 35 aboriginal aboriginal JJ work_seorv76asvbfzbdykrqsobtgea 36 36 tribes tribe NNS work_seorv76asvbfzbdykrqsobtgea 36 37 are be VBP work_seorv76asvbfzbdykrqsobtgea 36 38 considered consider VBN work_seorv76asvbfzbdykrqsobtgea 36 39 to to TO work_seorv76asvbfzbdykrqsobtgea 36 40 share share VB work_seorv76asvbfzbdykrqsobtgea 36 41 a a DT work_seorv76asvbfzbdykrqsobtgea 36 42 common common JJ work_seorv76asvbfzbdykrqsobtgea 36 43 origin origin NN work_seorv76asvbfzbdykrqsobtgea 36 44 , , , work_seorv76asvbfzbdykrqsobtgea 36 45 the the DT work_seorv76asvbfzbdykrqsobtgea 36 46 founder founder NN work_seorv76asvbfzbdykrqsobtgea 36 47 mutation mutation NN work_seorv76asvbfzbdykrqsobtgea 36 48 noted note VBN work_seorv76asvbfzbdykrqsobtgea 36 49 in in IN work_seorv76asvbfzbdykrqsobtgea 36 50 this this DT work_seorv76asvbfzbdykrqsobtgea 36 51 study study NN work_seorv76asvbfzbdykrqsobtgea 36 52 suggests suggest VBZ work_seorv76asvbfzbdykrqsobtgea 36 53 that that IN work_seorv76asvbfzbdykrqsobtgea 36 54 diversities diversity NNS work_seorv76asvbfzbdykrqsobtgea 36 55 among among IN work_seorv76asvbfzbdykrqsobtgea 36 56 the the DT work_seorv76asvbfzbdykrqsobtgea 36 57 different different JJ work_seorv76asvbfzbdykrqsobtgea 36 58 tribes tribe NNS work_seorv76asvbfzbdykrqsobtgea 36 59 in in IN work_seorv76asvbfzbdykrqsobtgea 36 60 Taiwan Taiwan NNP work_seorv76asvbfzbdykrqsobtgea 36 61 may may MD work_seorv76asvbfzbdykrqsobtgea 36 62 be be VB work_seorv76asvbfzbdykrqsobtgea 36 63 due due IN work_seorv76asvbfzbdykrqsobtgea 36 64 to to IN work_seorv76asvbfzbdykrqsobtgea 36 65 geographic geographic JJ work_seorv76asvbfzbdykrqsobtgea 36 66 isolation isolation NN work_seorv76asvbfzbdykrqsobtgea 36 67 over over IN work_seorv76asvbfzbdykrqsobtgea 36 68 a a DT work_seorv76asvbfzbdykrqsobtgea 36 69 long long JJ work_seorv76asvbfzbdykrqsobtgea 36 70 period period NN work_seorv76asvbfzbdykrqsobtgea 36 71 of of IN work_seorv76asvbfzbdykrqsobtgea 36 72 time time NN work_seorv76asvbfzbdykrqsobtgea 36 73 . . . work_seorv76asvbfzbdykrqsobtgea 37 1 Figure figure NN work_seorv76asvbfzbdykrqsobtgea 37 2 1 1 CD work_seorv76asvbfzbdykrqsobtgea 37 3 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 37 4 A a NN work_seorv76asvbfzbdykrqsobtgea 37 5 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 37 6 Patient patient NN work_seorv76asvbfzbdykrqsobtgea 37 7 6 6 CD work_seorv76asvbfzbdykrqsobtgea 37 8 shows show NNS work_seorv76asvbfzbdykrqsobtgea 37 9 very very RB work_seorv76asvbfzbdykrqsobtgea 37 10 tight tight JJ work_seorv76asvbfzbdykrqsobtgea 37 11 and and CC work_seorv76asvbfzbdykrqsobtgea 37 12 rigid rigid JJ work_seorv76asvbfzbdykrqsobtgea 37 13 skin skin NN work_seorv76asvbfzbdykrqsobtgea 37 14 with with IN work_seorv76asvbfzbdykrqsobtgea 37 15 erosions erosion NNS work_seorv76asvbfzbdykrqsobtgea 37 16 , , , work_seorv76asvbfzbdykrqsobtgea 37 17 prominent prominent JJ work_seorv76asvbfzbdykrqsobtgea 37 18 superficial superficial JJ work_seorv76asvbfzbdykrqsobtgea 37 19 vasculature vasculature NN work_seorv76asvbfzbdykrqsobtgea 37 20 , , , work_seorv76asvbfzbdykrqsobtgea 37 21 joint joint JJ work_seorv76asvbfzbdykrqsobtgea 37 22 contrac- contrac- NN work_seorv76asvbfzbdykrqsobtgea 37 23 tures ture NNS work_seorv76asvbfzbdykrqsobtgea 37 24 , , , work_seorv76asvbfzbdykrqsobtgea 37 25 and and CC work_seorv76asvbfzbdykrqsobtgea 37 26 facial facial JJ work_seorv76asvbfzbdykrqsobtgea 37 27 features feature NNS work_seorv76asvbfzbdykrqsobtgea 37 28 including include VBG work_seorv76asvbfzbdykrqsobtgea 37 29 fixed fix VBN work_seorv76asvbfzbdykrqsobtgea 37 30 facial facial JJ work_seorv76asvbfzbdykrqsobtgea 37 31 expression expression NN work_seorv76asvbfzbdykrqsobtgea 37 32 , , , work_seorv76asvbfzbdykrqsobtgea 37 33 absent absent JJ work_seorv76asvbfzbdykrqsobtgea 37 34 eyelashes eyelash NNS work_seorv76asvbfzbdykrqsobtgea 37 35 and and CC work_seorv76asvbfzbdykrqsobtgea 37 36 eyebrows eyebrow NNS work_seorv76asvbfzbdykrqsobtgea 37 37 , , , work_seorv76asvbfzbdykrqsobtgea 37 38 small small JJ work_seorv76asvbfzbdykrqsobtgea 37 39 mouth mouth NN work_seorv76asvbfzbdykrqsobtgea 37 40 in in IN work_seorv76asvbfzbdykrqsobtgea 37 41 O o NN work_seorv76asvbfzbdykrqsobtgea 37 42 position position NN work_seorv76asvbfzbdykrqsobtgea 37 43 , , , work_seorv76asvbfzbdykrqsobtgea 37 44 and and CC work_seorv76asvbfzbdykrqsobtgea 37 45 micrognathia micrognathia NNP work_seorv76asvbfzbdykrqsobtgea 37 46 . . . work_seorv76asvbfzbdykrqsobtgea 38 1 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 38 2 B b NN work_seorv76asvbfzbdykrqsobtgea 38 3 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 38 4 Direct direct JJ work_seorv76asvbfzbdykrqsobtgea 38 5 sequencing sequencing NN work_seorv76asvbfzbdykrqsobtgea 38 6 over over IN work_seorv76asvbfzbdykrqsobtgea 38 7 the the DT work_seorv76asvbfzbdykrqsobtgea 38 8 ZPMSTE24 ZPMSTE24 NNP work_seorv76asvbfzbdykrqsobtgea 38 9 gene gene NN work_seorv76asvbfzbdykrqsobtgea 38 10 in in IN work_seorv76asvbfzbdykrqsobtgea 38 11 Patient Patient NNP work_seorv76asvbfzbdykrqsobtgea 38 12 8 8 CD work_seorv76asvbfzbdykrqsobtgea 38 13 showing show VBG work_seorv76asvbfzbdykrqsobtgea 38 14 a a DT work_seorv76asvbfzbdykrqsobtgea 38 15 homozygous homozygous JJ work_seorv76asvbfzbdykrqsobtgea 38 16 stop stop NN work_seorv76asvbfzbdykrqsobtgea 38 17 codon codon NN work_seorv76asvbfzbdykrqsobtgea 38 18 TAA TAA NNP work_seorv76asvbfzbdykrqsobtgea 38 19 over over IN work_seorv76asvbfzbdykrqsobtgea 38 20 the the DT work_seorv76asvbfzbdykrqsobtgea 38 21 exon exon JJ work_seorv76asvbfzbdykrqsobtgea 38 22 6 6 CD work_seorv76asvbfzbdykrqsobtgea 38 23 [ [ -LRB- work_seorv76asvbfzbdykrqsobtgea 38 24 c.715 c.715 NN work_seorv76asvbfzbdykrqsobtgea 38 25 G g NN work_seorv76asvbfzbdykrqsobtgea 38 26 > > XX work_seorv76asvbfzbdykrqsobtgea 38 27 T t NN work_seorv76asvbfzbdykrqsobtgea 38 28 leading lead VBG work_seorv76asvbfzbdykrqsobtgea 38 29 to to IN work_seorv76asvbfzbdykrqsobtgea 38 30 GAA GAA NNP work_seorv76asvbfzbdykrqsobtgea 38 31 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 38 32 glutamic glutamic NNP work_seorv76asvbfzbdykrqsobtgea 38 33 acid)/ acid)/ NNP work_seorv76asvbfzbdykrqsobtgea 38 34 TAA(stop TAA(stop NNP work_seorv76asvbfzbdykrqsobtgea 38 35 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 38 36 , , , work_seorv76asvbfzbdykrqsobtgea 38 37 p p NN work_seorv76asvbfzbdykrqsobtgea 38 38 . . . work_seorv76asvbfzbdykrqsobtgea 38 39 E239X E239X NNP work_seorv76asvbfzbdykrqsobtgea 38 40 ] ] -RRB- work_seorv76asvbfzbdykrqsobtgea 38 41 . . . work_seorv76asvbfzbdykrqsobtgea 39 1 Both both DT work_seorv76asvbfzbdykrqsobtgea 39 2 parents parent NNS work_seorv76asvbfzbdykrqsobtgea 39 3 are be VBP work_seorv76asvbfzbdykrqsobtgea 39 4 heterozygous heterozygous JJ work_seorv76asvbfzbdykrqsobtgea 39 5 carriers carrier NNS work_seorv76asvbfzbdykrqsobtgea 39 6 . . . work_seorv76asvbfzbdykrqsobtgea 40 1 Lethal lethal JJ work_seorv76asvbfzbdykrqsobtgea 40 2 restrictive restrictive JJ work_seorv76asvbfzbdykrqsobtgea 40 3 dermopathy dermopathy NN work_seorv76asvbfzbdykrqsobtgea 40 4 in in IN work_seorv76asvbfzbdykrqsobtgea 40 5 Taiwan Taiwan NNP work_seorv76asvbfzbdykrqsobtgea 40 6 1019 1019 CD work_seorv76asvbfzbdykrqsobtgea 40 7 References reference NNS work_seorv76asvbfzbdykrqsobtgea 40 8 1 1 CD work_seorv76asvbfzbdykrqsobtgea 40 9 . . . work_seorv76asvbfzbdykrqsobtgea 41 1 Hou Hou NNP work_seorv76asvbfzbdykrqsobtgea 41 2 JW JW NNP work_seorv76asvbfzbdykrqsobtgea 41 3 , , , work_seorv76asvbfzbdykrqsobtgea 41 4 Mai Mai NNP work_seorv76asvbfzbdykrqsobtgea 41 5 CF CF NNP work_seorv76asvbfzbdykrqsobtgea 41 6 . . . work_seorv76asvbfzbdykrqsobtgea 42 1 Restrictive restrictive JJ work_seorv76asvbfzbdykrqsobtgea 42 2 dermopathy dermopathy NN work_seorv76asvbfzbdykrqsobtgea 42 3 in in IN work_seorv76asvbfzbdykrqsobtgea 42 4 two two CD work_seorv76asvbfzbdykrqsobtgea 42 5 sisters sister NNS work_seorv76asvbfzbdykrqsobtgea 42 6 . . . work_seorv76asvbfzbdykrqsobtgea 43 1 Chang Chang NNP work_seorv76asvbfzbdykrqsobtgea 43 2 Gung Gung NNP work_seorv76asvbfzbdykrqsobtgea 43 3 Med Med NNP work_seorv76asvbfzbdykrqsobtgea 43 4 J J NNP work_seorv76asvbfzbdykrqsobtgea 43 5 2003;26:510e4 2003;26:510e4 CD work_seorv76asvbfzbdykrqsobtgea 43 6 . . . work_seorv76asvbfzbdykrqsobtgea 44 1 2 2 LS work_seorv76asvbfzbdykrqsobtgea 44 2 . . . work_seorv76asvbfzbdykrqsobtgea 45 1 Chiang Chiang NNP work_seorv76asvbfzbdykrqsobtgea 45 2 MC MC NNP work_seorv76asvbfzbdykrqsobtgea 45 3 , , , work_seorv76asvbfzbdykrqsobtgea 45 4 Huang Huang NNP work_seorv76asvbfzbdykrqsobtgea 45 5 SF SF NNP work_seorv76asvbfzbdykrqsobtgea 45 6 , , , work_seorv76asvbfzbdykrqsobtgea 45 7 Hsueh Hsueh NNP work_seorv76asvbfzbdykrqsobtgea 45 8 C C NNP work_seorv76asvbfzbdykrqsobtgea 45 9 , , , work_seorv76asvbfzbdykrqsobtgea 45 10 Lai Lai NNP work_seorv76asvbfzbdykrqsobtgea 45 11 MW MW NNP work_seorv76asvbfzbdykrqsobtgea 45 12 , , , work_seorv76asvbfzbdykrqsobtgea 45 13 Hou Hou NNP work_seorv76asvbfzbdykrqsobtgea 45 14 JW JW NNP work_seorv76asvbfzbdykrqsobtgea 45 15 . . . work_seorv76asvbfzbdykrqsobtgea 46 1 Restrictive restrictive JJ work_seorv76asvbfzbdykrqsobtgea 46 2 dermopathy dermopathy NN work_seorv76asvbfzbdykrqsobtgea 46 3 : : : work_seorv76asvbfzbdykrqsobtgea 46 4 report report NN work_seorv76asvbfzbdykrqsobtgea 46 5 of of IN work_seorv76asvbfzbdykrqsobtgea 46 6 one one CD work_seorv76asvbfzbdykrqsobtgea 46 7 case case NN work_seorv76asvbfzbdykrqsobtgea 46 8 and and CC work_seorv76asvbfzbdykrqsobtgea 46 9 the the DT work_seorv76asvbfzbdykrqsobtgea 46 10 metabolic metabolic NN work_seorv76asvbfzbdykrqsobtgea 46 11 and and CC work_seorv76asvbfzbdykrqsobtgea 46 12 post- post- NNP work_seorv76asvbfzbdykrqsobtgea 46 13 mortem mortem NNP work_seorv76asvbfzbdykrqsobtgea 46 14 findings finding NNS work_seorv76asvbfzbdykrqsobtgea 46 15 . . . work_seorv76asvbfzbdykrqsobtgea 47 1 Turk Turk NNP work_seorv76asvbfzbdykrqsobtgea 47 2 J J NNP work_seorv76asvbfzbdykrqsobtgea 47 3 Pediatr Pediatr NNP work_seorv76asvbfzbdykrqsobtgea 47 4 2008;50:492e4 2008;50:492e4 CD work_seorv76asvbfzbdykrqsobtgea 47 5 . . . work_seorv76asvbfzbdykrqsobtgea 48 1 3 3 LS work_seorv76asvbfzbdykrqsobtgea 48 2 . . . work_seorv76asvbfzbdykrqsobtgea 49 1 Chen Chen NNP work_seorv76asvbfzbdykrqsobtgea 49 2 M M NNP work_seorv76asvbfzbdykrqsobtgea 49 3 , , , work_seorv76asvbfzbdykrqsobtgea 49 4 Kuo Kuo NNP work_seorv76asvbfzbdykrqsobtgea 49 5 HH HH NNP work_seorv76asvbfzbdykrqsobtgea 49 6 , , , work_seorv76asvbfzbdykrqsobtgea 49 7 Huang Huang NNP work_seorv76asvbfzbdykrqsobtgea 49 8 YC YC NNP work_seorv76asvbfzbdykrqsobtgea 49 9 , , , work_seorv76asvbfzbdykrqsobtgea 49 10 Ke Ke NNP work_seorv76asvbfzbdykrqsobtgea 49 11 YY YY NNP work_seorv76asvbfzbdykrqsobtgea 49 12 , , , work_seorv76asvbfzbdykrqsobtgea 49 13 Chang Chang NNP work_seorv76asvbfzbdykrqsobtgea 49 14 SP SP NNP work_seorv76asvbfzbdykrqsobtgea 49 15 , , , work_seorv76asvbfzbdykrqsobtgea 49 16 Chen Chen NNP work_seorv76asvbfzbdykrqsobtgea 49 17 CP CP NNP work_seorv76asvbfzbdykrqsobtgea 49 18 , , , work_seorv76asvbfzbdykrqsobtgea 49 19 et et NNP work_seorv76asvbfzbdykrqsobtgea 49 20 al al NNP work_seorv76asvbfzbdykrqsobtgea 49 21 . . . work_seorv76asvbfzbdykrqsobtgea 50 1 A a DT work_seorv76asvbfzbdykrqsobtgea 50 2 case case NN work_seorv76asvbfzbdykrqsobtgea 50 3 of of IN work_seorv76asvbfzbdykrqsobtgea 50 4 restrictive restrictive JJ work_seorv76asvbfzbdykrqsobtgea 50 5 dermopathy dermopathy NN work_seorv76asvbfzbdykrqsobtgea 50 6 with with IN work_seorv76asvbfzbdykrqsobtgea 50 7 complete complete JJ work_seorv76asvbfzbdykrqsobtgea 50 8 chorioamniotic chorioamniotic JJ work_seorv76asvbfzbdykrqsobtgea 50 9 membrane membrane NN work_seorv76asvbfzbdykrqsobtgea 50 10 separation separation NN work_seorv76asvbfzbdykrqsobtgea 50 11 caused cause VBN work_seorv76asvbfzbdykrqsobtgea 50 12 by by IN work_seorv76asvbfzbdykrqsobtgea 50 13 a a DT work_seorv76asvbfzbdykrqsobtgea 50 14 novel novel JJ work_seorv76asvbfzbdykrqsobtgea 50 15 homozygous homozygous JJ work_seorv76asvbfzbdykrqsobtgea 50 16 nonsense nonsense NN work_seorv76asvbfzbdykrqsobtgea 50 17 mutation mutation NN work_seorv76asvbfzbdykrqsobtgea 50 18 in in IN work_seorv76asvbfzbdykrqsobtgea 50 19 the the DT work_seorv76asvbfzbdykrqsobtgea 50 20 ZMPSTE24 ZMPSTE24 NNP work_seorv76asvbfzbdykrqsobtgea 50 21 gene gene NN work_seorv76asvbfzbdykrqsobtgea 50 22 . . . work_seorv76asvbfzbdykrqsobtgea 51 1 Am be VBP work_seorv76asvbfzbdykrqsobtgea 51 2 J J NNP work_seorv76asvbfzbdykrqsobtgea 51 3 Med Med NNP work_seorv76asvbfzbdykrqsobtgea 51 4 Genet Genet NNP work_seorv76asvbfzbdykrqsobtgea 51 5 2009;149A 2009;149a CD work_seorv76asvbfzbdykrqsobtgea 51 6 : : : work_seorv76asvbfzbdykrqsobtgea 51 7 1550e4 1550e4 CD work_seorv76asvbfzbdykrqsobtgea 51 8 . . . work_seorv76asvbfzbdykrqsobtgea 52 1 4 4 LS work_seorv76asvbfzbdykrqsobtgea 52 2 . . . work_seorv76asvbfzbdykrqsobtgea 53 1 Lu Lu NNP work_seorv76asvbfzbdykrqsobtgea 53 2 CS CS NNP work_seorv76asvbfzbdykrqsobtgea 53 3 , , , work_seorv76asvbfzbdykrqsobtgea 53 4 Wu Wu NNP work_seorv76asvbfzbdykrqsobtgea 53 5 SC SC NNP work_seorv76asvbfzbdykrqsobtgea 53 6 , , , work_seorv76asvbfzbdykrqsobtgea 53 7 Hou Hou NNP work_seorv76asvbfzbdykrqsobtgea 53 8 JW JW NNP work_seorv76asvbfzbdykrqsobtgea 53 9 , , , work_seorv76asvbfzbdykrqsobtgea 53 10 Chu Chu NNP work_seorv76asvbfzbdykrqsobtgea 53 11 CP CP NNP work_seorv76asvbfzbdykrqsobtgea 53 12 , , , work_seorv76asvbfzbdykrqsobtgea 53 13 Tseng Tseng NNP work_seorv76asvbfzbdykrqsobtgea 53 14 LL LL NNP work_seorv76asvbfzbdykrqsobtgea 53 15 , , , work_seorv76asvbfzbdykrqsobtgea 53 16 Lue Lue NNP work_seorv76asvbfzbdykrqsobtgea 53 17 HC HC NNP work_seorv76asvbfzbdykrqsobtgea 53 18 . . . work_seorv76asvbfzbdykrqsobtgea 54 1 Restrictive restrictive JJ work_seorv76asvbfzbdykrqsobtgea 54 2 dermopathy dermopathy NN work_seorv76asvbfzbdykrqsobtgea 54 3 : : : work_seorv76asvbfzbdykrqsobtgea 54 4 report report NN work_seorv76asvbfzbdykrqsobtgea 54 5 of of IN work_seorv76asvbfzbdykrqsobtgea 54 6 two two CD work_seorv76asvbfzbdykrqsobtgea 54 7 siblings sibling NNS work_seorv76asvbfzbdykrqsobtgea 54 8 . . . work_seorv76asvbfzbdykrqsobtgea 55 1 Pediatr Pediatr NNP work_seorv76asvbfzbdykrqsobtgea 55 2 Neonatol Neonatol NNP work_seorv76asvbfzbdykrqsobtgea 55 3 2013;54 2013;54 NNP work_seorv76asvbfzbdykrqsobtgea 55 4 : : : work_seorv76asvbfzbdykrqsobtgea 55 5 198e201 198e201 CD work_seorv76asvbfzbdykrqsobtgea 55 6 . . . work_seorv76asvbfzbdykrqsobtgea 56 1 5 5 CD work_seorv76asvbfzbdykrqsobtgea 56 2 . . . work_seorv76asvbfzbdykrqsobtgea 57 1 Loucks louck NNS work_seorv76asvbfzbdykrqsobtgea 57 2 C C NNP work_seorv76asvbfzbdykrqsobtgea 57 3 , , , work_seorv76asvbfzbdykrqsobtgea 57 4 Parboosingh Parboosingh NNP work_seorv76asvbfzbdykrqsobtgea 57 5 JS JS NNP work_seorv76asvbfzbdykrqsobtgea 57 6 , , , work_seorv76asvbfzbdykrqsobtgea 57 7 Chong Chong NNP work_seorv76asvbfzbdykrqsobtgea 57 8 JX JX NNP work_seorv76asvbfzbdykrqsobtgea 57 9 , , , work_seorv76asvbfzbdykrqsobtgea 57 10 Ober Ober NNP work_seorv76asvbfzbdykrqsobtgea 57 11 C C NNP work_seorv76asvbfzbdykrqsobtgea 57 12 , , , work_seorv76asvbfzbdykrqsobtgea 57 13 Siu Siu NNP work_seorv76asvbfzbdykrqsobtgea 57 14 VM VM NNP work_seorv76asvbfzbdykrqsobtgea 57 15 , , , work_seorv76asvbfzbdykrqsobtgea 57 16 Hegele Hegele NNP work_seorv76asvbfzbdykrqsobtgea 57 17 RA RA NNP work_seorv76asvbfzbdykrqsobtgea 57 18 , , , work_seorv76asvbfzbdykrqsobtgea 57 19 et et NNP work_seorv76asvbfzbdykrqsobtgea 57 20 al al NNP work_seorv76asvbfzbdykrqsobtgea 57 21 . . . work_seorv76asvbfzbdykrqsobtgea 58 1 A a DT work_seorv76asvbfzbdykrqsobtgea 58 2 shared share VBN work_seorv76asvbfzbdykrqsobtgea 58 3 founder founder NN work_seorv76asvbfzbdykrqsobtgea 58 4 mutation mutation NN work_seorv76asvbfzbdykrqsobtgea 58 5 underlies underlie NNS work_seorv76asvbfzbdykrqsobtgea 58 6 restrictive restrictive JJ work_seorv76asvbfzbdykrqsobtgea 58 7 dermopathy dermopathy NN work_seorv76asvbfzbdykrqsobtgea 58 8 in in IN work_seorv76asvbfzbdykrqsobtgea 58 9 Old Old NNP work_seorv76asvbfzbdykrqsobtgea 58 10 Colony Colony NNP work_seorv76asvbfzbdykrqsobtgea 58 11 ( ( -LRB- work_seorv76asvbfzbdykrqsobtgea 58 12 Dutch Dutch NNP work_seorv76asvbfzbdykrqsobtgea 58 13 - - HYPH work_seorv76asvbfzbdykrqsobtgea 58 14 German german JJ work_seorv76asvbfzbdykrqsobtgea 58 15 ) ) -RRB- work_seorv76asvbfzbdykrqsobtgea 58 16 Menno- Menno- NNP work_seorv76asvbfzbdykrqsobtgea 58 17 nite nite NN work_seorv76asvbfzbdykrqsobtgea 58 18 and and CC work_seorv76asvbfzbdykrqsobtgea 58 19 Hutterite Hutterite NNP work_seorv76asvbfzbdykrqsobtgea 58 20 patients patient NNS work_seorv76asvbfzbdykrqsobtgea 58 21 in in IN work_seorv76asvbfzbdykrqsobtgea 58 22 North North NNP work_seorv76asvbfzbdykrqsobtgea 58 23 America America NNP work_seorv76asvbfzbdykrqsobtgea 58 24 . . . work_seorv76asvbfzbdykrqsobtgea 59 1 Am be VBP work_seorv76asvbfzbdykrqsobtgea 59 2 J J NNP work_seorv76asvbfzbdykrqsobtgea 59 3 Med Med NNP work_seorv76asvbfzbdykrqsobtgea 59 4 Genet Genet NNP work_seorv76asvbfzbdykrqsobtgea 59 5 2012;158A:1229e32 2012;158A:1229e32 NNP work_seorv76asvbfzbdykrqsobtgea 59 6 . . . work_seorv76asvbfzbdykrqsobtgea 60 1 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref1 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref1 NNP work_seorv76asvbfzbdykrqsobtgea 60 2 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref1 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref1 NNP work_seorv76asvbfzbdykrqsobtgea 60 3 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref1 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref1 NNP work_seorv76asvbfzbdykrqsobtgea 60 4 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref2 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref2 NNP work_seorv76asvbfzbdykrqsobtgea 60 5 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref2 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref2 NNP work_seorv76asvbfzbdykrqsobtgea 60 6 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref2 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref2 NNP work_seorv76asvbfzbdykrqsobtgea 60 7 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref2 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref2 NNP work_seorv76asvbfzbdykrqsobtgea 60 8 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref3 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref3 NNP work_seorv76asvbfzbdykrqsobtgea 60 9 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref3 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref3 NNP work_seorv76asvbfzbdykrqsobtgea 60 10 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref3 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref3 NNP work_seorv76asvbfzbdykrqsobtgea 60 11 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref3 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref3 NNP work_seorv76asvbfzbdykrqsobtgea 60 12 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref3 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref3 NNP work_seorv76asvbfzbdykrqsobtgea 60 13 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref3 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref3 NNP work_seorv76asvbfzbdykrqsobtgea 60 14 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref4 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref4 NNP work_seorv76asvbfzbdykrqsobtgea 60 15 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref4 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref4 NNP work_seorv76asvbfzbdykrqsobtgea 60 16 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref4 http://refhub.elsevier.com/s0929-6646(14)00241-1/sref4 FW work_seorv76asvbfzbdykrqsobtgea 60 17 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref4 http://refhub.elsevier.com/s0929-6646(14)00241-1/sref4 UH work_seorv76asvbfzbdykrqsobtgea 60 18 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref5 http://refhub.elsevier.com/s0929-6646(14)00241-1/sref5 FW work_seorv76asvbfzbdykrqsobtgea 60 19 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref5 http://refhub.elsevier.com/s0929-6646(14)00241-1/sref5 FW work_seorv76asvbfzbdykrqsobtgea 60 20 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref5 http://refhub.elsevier.com/s0929-6646(14)00241-1/sref5 FW work_seorv76asvbfzbdykrqsobtgea 60 21 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref5 http://refhub.elsevier.com/s0929-6646(14)00241-1/sref5 FW work_seorv76asvbfzbdykrqsobtgea 60 22 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref5 http://refhub.elsevier.com/s0929-6646(14)00241-1/sref5 FW work_seorv76asvbfzbdykrqsobtgea 60 23 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref5 http://refhub.elsevier.com/S0929-6646(14)00241-1/sref5 NNP work_seorv76asvbfzbdykrqsobtgea 60 24 A a DT work_seorv76asvbfzbdykrqsobtgea 60 25 shared share VBN work_seorv76asvbfzbdykrqsobtgea 60 26 founder founder NN work_seorv76asvbfzbdykrqsobtgea 60 27 mutation mutation NN work_seorv76asvbfzbdykrqsobtgea 60 28 underlies underlie VBZ work_seorv76asvbfzbdykrqsobtgea 60 29 lethal lethal JJ work_seorv76asvbfzbdykrqsobtgea 60 30 restrictive restrictive JJ work_seorv76asvbfzbdykrqsobtgea 60 31 dermopathy dermopathy NN work_seorv76asvbfzbdykrqsobtgea 60 32 in in IN work_seorv76asvbfzbdykrqsobtgea 60 33 the the DT work_seorv76asvbfzbdykrqsobtgea 60 34 Austronesian austronesian JJ work_seorv76asvbfzbdykrqsobtgea 60 35 aboriginal aboriginal JJ work_seorv76asvbfzbdykrqsobtgea 60 36 Atayal Atayal NNP work_seorv76asvbfzbdykrqsobtgea 60 37 tribe tribe NN work_seorv76asvbfzbdykrqsobtgea 60 38 of of IN work_seorv76asvbfzbdykrqsobtgea 60 39 Taiwan Taiwan NNP work_seorv76asvbfzbdykrqsobtgea 60 40 References References NNPS