id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_jrn7vbflvrhylmwmyyidawtwzm	T T WARNER	The molecular genetics of the dystonias	1998	3	.pdf	application/pdf	3868	563	61	Genetic studies in both Jewish and non-Jewish populations have shown that early onset severe primary dystonia in a large non-Jewish French Canadian family with generalised dystonia.15 Linkage to this region was also found in families invariably began in a limb before subsequent generalisation, whereas, in most non-linked kindreds, the dystonia often had onset in the craniocervical region. for mutations.25 The fascinating finding was of a 3 bp deletion in the coding sequence found in all aVected and obligate carriers with chromosome 9 linked primary dystonia, found aVected relatives in 25% of patients.29 Linkage studies have excluded the DYT1 gene as a cause for focal dystonia in two families with cervical dystonia30 and, in Bressman et al examined the possible role of genetic susceptibility in the development of secondary dystonia.46 They analysed chromosome 9q34 haplotypes in 40 Ashkenazi Jewish patients with Idiopathic torsion dystonia assignment of a gene to chromosome 18p in a German family with adult onset,	./cache/work_jrn7vbflvrhylmwmyyidawtwzm.pdf	./txt/work_jrn7vbflvrhylmwmyyidawtwzm.txt