id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_7jin4ffxhfdsbiwpugggdx3jdy	Sarah H. Shaw	Allele Frequency Distributions in Pooled DNA Samples: Applications to Mapping Complex Disease Genes	1998	14	.pdf	application/pdf	8583	702	60	tested the accuracy of allele frequency estimates, in various DNA samples, by pooling DNA from multiple peak heights to estimate allele frequencies in pooled DNA samples. evaluated whether pooled DNA samples can be used to accurately assess allele frequencies on transmitted and described in this paper show that accurate, quantitative data on allele frequency in pools of DNA pools of DNA samples from ''affecteds'' and ''unaffecteds'' can be screened for genetic markers spanning a genome to identify loci with a marker allele can lead to direct statistical tests of linkage and association in pooled DNA samples. A tetranucleotide polymorphism within the VWF gene (12p13.3–12p13.2) was studied in 10 replicates of a single DNA pool constructed from 76 unrelated samples of CEPH parents. Figure 1 Accuracy of allele frequencies estimated from DNA pools. direct genotyping and from two DNA pools (27 HSCR affected offspring and their parents) for markers on human	./cache/work_7jin4ffxhfdsbiwpugggdx3jdy.pdf	./txt/work_7jin4ffxhfdsbiwpugggdx3jdy.txt