id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_2gjvbpqs2zfitgdto2tjwawi64	D. L. French	Platelet Glycoprotein IIb/IIIa Receptors and Glanzmann s Thrombasthenia	2000	4	.pdf	application/pdf	3774	389	62	Platelet Glycoprotein IIb/IIIa Receptors and Glanzmann's Thrombasthenia GPIIb/IIIa receptor (integrin aIIbb3), one of the most abundant cell surface receptors ('80 000 per platelet),8 which have identified a region of similar cation-binding characteristics in integrin b subunits.15 A number of structural models Glanzmann's thrombasthenia is an autosomal recessive disease that results in a functional deficiency of GPIIb/IIIa located between the second and third calcium-binding domains; a G449D(G418D) (patient LM)29 substitution, which Eight missense mutations identified in 9 patients with Glanzmann's thrombasthenia are located within the cation-binding mutations located within a b-propeller structure of an integrin Both mutations are located within the GPIIIa cytoplasmic domain, which is important for integrin activation and the mutations provide support for the role of the GPIIIa cytoplasmic tail in the function of the GPIIb/IIIa receptor complex. French and Seligsohn GPIIb/IIIa Receptor and Glanzmann's Thrombasthenia 609 mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb. J Clin Invest.	./cache/work_2gjvbpqs2zfitgdto2tjwawi64.pdf	./txt/work_2gjvbpqs2zfitgdto2tjwawi64.txt