id sid tid token lemma pos cord-344480-6tcush4w 1 1 key key JJ cord-344480-6tcush4w 1 2 : : : cord-344480-6tcush4w 1 3 cord-344480 cord-344480 NN cord-344480-6tcush4w 1 4 - - : cord-344480-6tcush4w 1 5 6tcush4w 6tcush4w ADD cord-344480-6tcush4w 2 1 authors author NNS cord-344480-6tcush4w 2 2 : : : cord-344480-6tcush4w 2 3 Zhou Zhou NNP cord-344480-6tcush4w 2 4 , , , cord-344480-6tcush4w 2 5 Guangbiao Guangbiao NNP cord-344480-6tcush4w 2 6 ; ; : cord-344480-6tcush4w 2 7 Chen Chen NNP cord-344480-6tcush4w 2 8 , , , cord-344480-6tcush4w 2 9 Saijuan Saijuan NNP cord-344480-6tcush4w 2 10 ; ; : cord-344480-6tcush4w 2 11 Chen Chen NNP cord-344480-6tcush4w 2 12 , , , cord-344480-6tcush4w 3 1 Zhu Zhu NNP cord-344480-6tcush4w 3 2 title title NN cord-344480-6tcush4w 3 3 : : : cord-344480-6tcush4w 4 1 Back back RB cord-344480-6tcush4w 4 2 to to IN cord-344480-6tcush4w 4 3 the the DT cord-344480-6tcush4w 4 4 spring spring NN cord-344480-6tcush4w 4 5 of of IN cord-344480-6tcush4w 4 6 Wuhan Wuhan NNP cord-344480-6tcush4w 4 7 : : : cord-344480-6tcush4w 4 8 facts fact NNS cord-344480-6tcush4w 4 9 and and CC cord-344480-6tcush4w 4 10 hope hope NN cord-344480-6tcush4w 4 11 of of IN cord-344480-6tcush4w 4 12 COVID-19 covid-19 JJ cord-344480-6tcush4w 4 13 outbreak outbreak NN cord-344480-6tcush4w 4 14 date date NN cord-344480-6tcush4w 4 15 : : : cord-344480-6tcush4w 4 16 2020 2020 CD cord-344480-6tcush4w 4 17 - - HYPH cord-344480-6tcush4w 4 18 03 03 CD cord-344480-6tcush4w 4 19 - - SYM cord-344480-6tcush4w 4 20 14 14 CD cord-344480-6tcush4w 4 21 journal journal NN cord-344480-6tcush4w 4 22 : : : cord-344480-6tcush4w 5 1 Front front JJ cord-344480-6tcush4w 5 2 Med Med NNP cord-344480-6tcush4w 5 3 DOI doi NN cord-344480-6tcush4w 5 4 : : : cord-344480-6tcush4w 5 5 10.1007 10.1007 CD cord-344480-6tcush4w 5 6 / / SYM cord-344480-6tcush4w 5 7 s11684 s11684 NN cord-344480-6tcush4w 5 8 - - HYPH cord-344480-6tcush4w 5 9 020 020 CD cord-344480-6tcush4w 5 10 - - HYPH cord-344480-6tcush4w 5 11 0758 0758 CD cord-344480-6tcush4w 5 12 - - SYM cord-344480-6tcush4w 5 13 9 9 CD cord-344480-6tcush4w 6 1 sha sha NNP cord-344480-6tcush4w 6 2 : : : cord-344480-6tcush4w 6 3 4c8c72c02aa94b09431d8c410c6897a3c6f78ead 4c8c72c02aa94b09431d8c410c6897a3c6f78ead LS cord-344480-6tcush4w 6 4 doc_id doc_id CD cord-344480-6tcush4w 6 5 : : : cord-344480-6tcush4w 6 6 344480 344480 CD cord-344480-6tcush4w 6 7 cord_uid cord_uid NNS cord-344480-6tcush4w 6 8 : : : cord-344480-6tcush4w 6 9 6tcush4w 6tcush4w ADD cord-344480-6tcush4w 7 1 nan nan NNP cord-344480-6tcush4w 8 1 Since since IN cord-344480-6tcush4w 8 2 December December NNP cord-344480-6tcush4w 8 3 2019 2019 CD cord-344480-6tcush4w 8 4 , , , cord-344480-6tcush4w 8 5 an an DT cord-344480-6tcush4w 8 6 atypical atypical JJ cord-344480-6tcush4w 8 7 pneumonia pneumonia NN cord-344480-6tcush4w 8 8 has have VBZ cord-344480-6tcush4w 8 9 been be VBN cord-344480-6tcush4w 8 10 spreading spread VBG cord-344480-6tcush4w 8 11 from from IN cord-344480-6tcush4w 8 12 Wuhan Wuhan NNP cord-344480-6tcush4w 8 13 , , , cord-344480-6tcush4w 8 14 a a DT cord-344480-6tcush4w 8 15 beautiful beautiful JJ cord-344480-6tcush4w 8 16 city city NN cord-344480-6tcush4w 8 17 located locate VBN cord-344480-6tcush4w 8 18 at at IN cord-344480-6tcush4w 8 19 the the DT cord-344480-6tcush4w 8 20 center center NN cord-344480-6tcush4w 8 21 of of IN cord-344480-6tcush4w 8 22 China China NNP cord-344480-6tcush4w 8 23 ( ( -LRB- cord-344480-6tcush4w 8 24 Fig Fig NNP cord-344480-6tcush4w 8 25 . . . cord-344480-6tcush4w 8 26 1 1 CD cord-344480-6tcush4w 8 27 ) ) -RRB- cord-344480-6tcush4w 8 28 , , , cord-344480-6tcush4w 8 29 to to IN cord-344480-6tcush4w 8 30 the the DT cord-344480-6tcush4w 8 31 whole whole JJ cord-344480-6tcush4w 8 32 country country NN cord-344480-6tcush4w 8 33 . . . cord-344480-6tcush4w 9 1 This this DT cord-344480-6tcush4w 9 2 disease disease NN cord-344480-6tcush4w 9 3 originated originate VBD cord-344480-6tcush4w 9 4 from from IN cord-344480-6tcush4w 9 5 the the DT cord-344480-6tcush4w 9 6 Huanan Huanan NNP cord-344480-6tcush4w 9 7 Seafood Seafood NNP cord-344480-6tcush4w 9 8 Wholesale Wholesale NNP cord-344480-6tcush4w 9 9 Market Market NNP cord-344480-6tcush4w 9 10 that that WDT cord-344480-6tcush4w 9 11 was be VBD cord-344480-6tcush4w 9 12 closed close VBN cord-344480-6tcush4w 9 13 on on IN cord-344480-6tcush4w 9 14 January January NNP cord-344480-6tcush4w 9 15 1 1 CD cord-344480-6tcush4w 9 16 , , , cord-344480-6tcush4w 9 17 2020 2020 CD cord-344480-6tcush4w 9 18 . . . cord-344480-6tcush4w 10 1 Very very RB cord-344480-6tcush4w 10 2 rapidly rapidly RB cord-344480-6tcush4w 10 3 , , , cord-344480-6tcush4w 10 4 a a DT cord-344480-6tcush4w 10 5 novel novel JJ cord-344480-6tcush4w 10 6 coronavirus coronavirus NN cord-344480-6tcush4w 10 7 was be VBD cord-344480-6tcush4w 10 8 isolated isolate VBN cord-344480-6tcush4w 10 9 and and CC cord-344480-6tcush4w 10 10 named name VBN cord-344480-6tcush4w 10 11 first first RB cord-344480-6tcush4w 10 12 the the DT cord-344480-6tcush4w 10 13 2019 2019 CD cord-344480-6tcush4w 10 14 novel novel NN cord-344480-6tcush4w 10 15 coronavirus coronavirus NN cord-344480-6tcush4w 10 16 ( ( -LRB- cord-344480-6tcush4w 10 17 2019-nCoV 2019-ncov CD cord-344480-6tcush4w 10 18 ) ) -RRB- cord-344480-6tcush4w 10 19 [ [ -LRB- cord-344480-6tcush4w 10 20 1 1 CD cord-344480-6tcush4w 10 21 ] ] -RRB- cord-344480-6tcush4w 10 22 and and CC cord-344480-6tcush4w 10 23 subsequently subsequently RB cord-344480-6tcush4w 10 24 severe severe JJ cord-344480-6tcush4w 10 25 acute acute JJ cord-344480-6tcush4w 10 26 respiratory respiratory JJ cord-344480-6tcush4w 10 27 syndrome syndrome NN cord-344480-6tcush4w 10 28 coronavirus coronavirus NN cord-344480-6tcush4w 10 29 2 2 CD cord-344480-6tcush4w 10 30 ( ( -LRB- cord-344480-6tcush4w 10 31 SARS SARS NNP cord-344480-6tcush4w 10 32 - - HYPH cord-344480-6tcush4w 10 33 CoV-2 CoV-2 NNP cord-344480-6tcush4w 10 34 ) ) -RRB- cord-344480-6tcush4w 10 35 [ [ -LRB- cord-344480-6tcush4w 10 36 2 2 CD cord-344480-6tcush4w 10 37 ] ] -RRB- cord-344480-6tcush4w 10 38 , , , cord-344480-6tcush4w 10 39 and and CC cord-344480-6tcush4w 10 40 is be VBZ cord-344480-6tcush4w 10 41 suggested suggest VBN cord-344480-6tcush4w 10 42 to to TO cord-344480-6tcush4w 10 43 be be VB cord-344480-6tcush4w 10 44 named name VBN cord-344480-6tcush4w 10 45 as as IN cord-344480-6tcush4w 10 46 human human JJ cord-344480-6tcush4w 10 47 coronavirus coronavirus NN cord-344480-6tcush4w 10 48 2019 2019 CD cord-344480-6tcush4w 10 49 ( ( -LRB- cord-344480-6tcush4w 10 50 HCoV-19 HCoV-19 NNP cord-344480-6tcush4w 10 51 ) ) -RRB- cord-344480-6tcush4w 10 52 [ [ -LRB- cord-344480-6tcush4w 10 53 3 3 CD cord-344480-6tcush4w 10 54 ] ] -RRB- cord-344480-6tcush4w 10 55 . . . cord-344480-6tcush4w 11 1 Meanwhile meanwhile RB cord-344480-6tcush4w 11 2 , , , cord-344480-6tcush4w 11 3 the the DT cord-344480-6tcush4w 11 4 disease disease NN cord-344480-6tcush4w 11 5 is be VBZ cord-344480-6tcush4w 11 6 chronologically chronologically RB cord-344480-6tcush4w 11 7 called call VBN cord-344480-6tcush4w 11 8 pneumonia pneumonia NN cord-344480-6tcush4w 11 9 of of IN cord-344480-6tcush4w 11 10 unknown unknown JJ cord-344480-6tcush4w 11 11 origin origin NN cord-344480-6tcush4w 11 12 , , , cord-344480-6tcush4w 11 13 novel novel JJ cord-344480-6tcush4w 11 14 coronavirus coronavirus NN cord-344480-6tcush4w 11 15 pneumonia pneumonia NN cord-344480-6tcush4w 11 16 ( ( -LRB- cord-344480-6tcush4w 11 17 NCP NCP NNP cord-344480-6tcush4w 11 18 ) ) -RRB- cord-344480-6tcush4w 11 19 , , , cord-344480-6tcush4w 11 20 and and CC cord-344480-6tcush4w 11 21 coronavirus coronavirus NN cord-344480-6tcush4w 11 22 disease-2019 disease-2019 NNP cord-344480-6tcush4w 11 23 ( ( -LRB- cord-344480-6tcush4w 11 24 COVID-19 covid-19 NN cord-344480-6tcush4w 11 25 ) ) -RRB- cord-344480-6tcush4w 12 1 ( ( -LRB- cord-344480-6tcush4w 12 2 Fig Fig NNP cord-344480-6tcush4w 12 3 . . NNP cord-344480-6tcush4w 12 4 2 2 CD cord-344480-6tcush4w 12 5 ) ) -RRB- cord-344480-6tcush4w 12 6 . . . cord-344480-6tcush4w 13 1 Superspreading superspreade VBG cord-344480-6tcush4w 13 2 events event NNS cord-344480-6tcush4w 13 3 of of IN cord-344480-6tcush4w 13 4 this this DT cord-344480-6tcush4w 13 5 virus virus NN cord-344480-6tcush4w 13 6 have have VBP cord-344480-6tcush4w 13 7 also also RB cord-344480-6tcush4w 13 8 taken take VBN cord-344480-6tcush4w 13 9 place place NN cord-344480-6tcush4w 13 10 on on IN cord-344480-6tcush4w 13 11 the the DT cord-344480-6tcush4w 13 12 Diamond Diamond NNP cord-344480-6tcush4w 13 13 Princess Princess NNP cord-344480-6tcush4w 13 14 cruise cruise VB cord-344480-6tcush4w 13 15 off off IN cord-344480-6tcush4w 13 16 the the DT cord-344480-6tcush4w 13 17 coast coast NN cord-344480-6tcush4w 13 18 of of IN cord-344480-6tcush4w 13 19 Yokohama Yokohama NNP cord-344480-6tcush4w 13 20 , , , cord-344480-6tcush4w 13 21 Japan Japan NNP cord-344480-6tcush4w 13 22 [ [ -LRB- cord-344480-6tcush4w 13 23 4 4 CD cord-344480-6tcush4w 13 24 ] ] -RRB- cord-344480-6tcush4w 13 25 . . . cord-344480-6tcush4w 14 1 The the DT cord-344480-6tcush4w 14 2 Chinese chinese JJ cord-344480-6tcush4w 14 3 central central JJ cord-344480-6tcush4w 14 4 [ [ -LRB- cord-344480-6tcush4w 14 5 5 5 CD cord-344480-6tcush4w 14 6 ] ] -RRB- cord-344480-6tcush4w 14 7 and and CC cord-344480-6tcush4w 14 8 local local JJ cord-344480-6tcush4w 14 9 governments government NNS cord-344480-6tcush4w 14 10 [ [ -LRB- cord-344480-6tcush4w 14 11 6 6 CD cord-344480-6tcush4w 14 12 ] ] -RRB- cord-344480-6tcush4w 14 13 have have VBP cord-344480-6tcush4w 14 14 been be VBN cord-344480-6tcush4w 14 15 endeavoring endeavor VBG cord-344480-6tcush4w 14 16 unprecedented unprecedented JJ cord-344480-6tcush4w 14 17 efforts effort NNS cord-344480-6tcush4w 14 18 to to TO cord-344480-6tcush4w 14 19 constrain constrain VB cord-344480-6tcush4w 14 20 the the DT cord-344480-6tcush4w 14 21 outbreak outbreak NN cord-344480-6tcush4w 14 22 , , , cord-344480-6tcush4w 14 23 and and CC cord-344480-6tcush4w 14 24 more more JJR cord-344480-6tcush4w 14 25 than than IN cord-344480-6tcush4w 14 26 30 30 CD cord-344480-6tcush4w 14 27 000 000 CD cord-344480-6tcush4w 14 28 medical medical JJ cord-344480-6tcush4w 14 29 professionals professional NNS cord-344480-6tcush4w 14 30 especially especially RB cord-344480-6tcush4w 14 31 doctors doctor NNS cord-344480-6tcush4w 14 32 and and CC cord-344480-6tcush4w 14 33 nurses nurse NNS cord-344480-6tcush4w 14 34 outside outside IN cord-344480-6tcush4w 14 35 Wuhan Wuhan NNP cord-344480-6tcush4w 14 36 have have VBP cord-344480-6tcush4w 14 37 been be VBN cord-344480-6tcush4w 14 38 joining join VBG cord-344480-6tcush4w 14 39 the the DT cord-344480-6tcush4w 14 40 local local JJ cord-344480-6tcush4w 14 41 ones one NNS cord-344480-6tcush4w 14 42 to to TO cord-344480-6tcush4w 14 43 handle handle VB cord-344480-6tcush4w 14 44 this this DT cord-344480-6tcush4w 14 45 emergency emergency NN cord-344480-6tcush4w 14 46 . . . cord-344480-6tcush4w 15 1 In in IN cord-344480-6tcush4w 15 2 early early JJ cord-344480-6tcush4w 15 3 December December NNP cord-344480-6tcush4w 15 4 2019 2019 CD cord-344480-6tcush4w 15 5 , , , cord-344480-6tcush4w 15 6 the the DT cord-344480-6tcush4w 15 7 first first JJ cord-344480-6tcush4w 15 8 case case NN cord-344480-6tcush4w 15 9 was be VBD cord-344480-6tcush4w 15 10 reported report VBN cord-344480-6tcush4w 15 11 ; ; : cord-344480-6tcush4w 15 12 by by IN cord-344480-6tcush4w 15 13 December December NNP cord-344480-6tcush4w 15 14 31 31 CD cord-344480-6tcush4w 15 15 , , , cord-344480-6tcush4w 15 16 104 104 CD cord-344480-6tcush4w 15 17 cases case NNS cord-344480-6tcush4w 15 18 were be VBD cord-344480-6tcush4w 15 19 diagnosed diagnose VBN cord-344480-6tcush4w 15 20 [ [ -LRB- cord-344480-6tcush4w 15 21 7 7 CD cord-344480-6tcush4w 15 22 ] ] -RRB- cord-344480-6tcush4w 15 23 . . . cord-344480-6tcush4w 16 1 The the DT cord-344480-6tcush4w 16 2 disease disease NN cord-344480-6tcush4w 16 3 took take VBD cord-344480-6tcush4w 16 4 30 30 CD cord-344480-6tcush4w 16 5 days day NNS cord-344480-6tcush4w 16 6 to to TO cord-344480-6tcush4w 16 7 spread spread VB cord-344480-6tcush4w 16 8 to to IN cord-344480-6tcush4w 16 9 all all PDT cord-344480-6tcush4w 16 10 the the DT cord-344480-6tcush4w 16 11 34 34 CD cord-344480-6tcush4w 16 12 provinces province NNS cord-344480-6tcush4w 16 13 / / SYM cord-344480-6tcush4w 16 14 regions region NNS cord-344480-6tcush4w 16 15 ( ( -LRB- cord-344480-6tcush4w 16 16 including include VBG cord-344480-6tcush4w 16 17 Hong Hong NNP cord-344480-6tcush4w 16 18 Kong Kong NNP cord-344480-6tcush4w 16 19 , , , cord-344480-6tcush4w 16 20 Macao Macao NNP cord-344480-6tcush4w 16 21 , , , cord-344480-6tcush4w 16 22 and and CC cord-344480-6tcush4w 16 23 Taiwan Taiwan NNP cord-344480-6tcush4w 16 24 ) ) -RRB- cord-344480-6tcush4w 16 25 of of IN cord-344480-6tcush4w 16 26 China China NNP cord-344480-6tcush4w 16 27 . . . cord-344480-6tcush4w 17 1 The the DT cord-344480-6tcush4w 17 2 number number NN cord-344480-6tcush4w 17 3 of of IN cord-344480-6tcush4w 17 4 confirmed confirm VBN cord-344480-6tcush4w 17 5 cases case NNS cord-344480-6tcush4w 17 6 of of IN cord-344480-6tcush4w 17 7 COVID-19 COVID-19 NNP cord-344480-6tcush4w 17 8 rose rise VBD cord-344480-6tcush4w 17 9 to to IN cord-344480-6tcush4w 17 10 11 11 CD cord-344480-6tcush4w 17 11 791 791 CD cord-344480-6tcush4w 17 12 in in IN cord-344480-6tcush4w 17 13 Chinese chinese JJ cord-344480-6tcush4w 17 14 mainland mainland NN cord-344480-6tcush4w 17 15 as as IN cord-344480-6tcush4w 17 16 of of IN cord-344480-6tcush4w 17 17 January January NNP cord-344480-6tcush4w 17 18 31 31 CD cord-344480-6tcush4w 17 19 , , , cord-344480-6tcush4w 17 20 including include VBG cord-344480-6tcush4w 17 21 259 259 CD cord-344480-6tcush4w 17 22 deaths death NNS cord-344480-6tcush4w 17 23 . . . cord-344480-6tcush4w 18 1 The the DT cord-344480-6tcush4w 18 2 confirmed confirm VBN cord-344480-6tcush4w 18 3 cases case NNS cord-344480-6tcush4w 18 4 increased increase VBD cord-344480-6tcush4w 18 5 rapidly rapidly RB cord-344480-6tcush4w 18 6 , , , cord-344480-6tcush4w 18 7 and and CC cord-344480-6tcush4w 18 8 by by IN cord-344480-6tcush4w 18 9 February February NNP cord-344480-6tcush4w 18 10 21 21 CD cord-344480-6tcush4w 18 11 , , , cord-344480-6tcush4w 18 12 75 75 CD cord-344480-6tcush4w 18 13 567 567 CD cord-344480-6tcush4w 18 14 confirmed confirm VBD cord-344480-6tcush4w 18 15 cases case NNS cord-344480-6tcush4w 18 16 , , , cord-344480-6tcush4w 18 17 5206 5206 CD cord-344480-6tcush4w 18 18 suspected suspect VBN cord-344480-6tcush4w 18 19 cases case NNS cord-344480-6tcush4w 18 20 , , , cord-344480-6tcush4w 18 21 and and CC cord-344480-6tcush4w 18 22 2239 2239 CD cord-344480-6tcush4w 18 23 deaths death NNS cord-344480-6tcush4w 18 24 , , , cord-344480-6tcush4w 18 25 have have VBP cord-344480-6tcush4w 18 26 been be VBN cord-344480-6tcush4w 18 27 reported report VBN cord-344480-6tcush4w 18 28 in in IN cord-344480-6tcush4w 18 29 China China NNP cord-344480-6tcush4w 18 30 . . . cord-344480-6tcush4w 19 1 The the DT cord-344480-6tcush4w 19 2 disease disease NN cord-344480-6tcush4w 19 3 also also RB cord-344480-6tcush4w 19 4 spread spread VBD cord-344480-6tcush4w 19 5 to to IN cord-344480-6tcush4w 19 6 26 26 CD cord-344480-6tcush4w 19 7 countries country NNS cord-344480-6tcush4w 19 8 , , , cord-344480-6tcush4w 19 9 with with IN cord-344480-6tcush4w 19 10 1151 1151 CD cord-344480-6tcush4w 19 11 confirmed confirm VBN cord-344480-6tcush4w 19 12 cases case NNS cord-344480-6tcush4w 19 13 and and CC cord-344480-6tcush4w 19 14 8 8 CD cord-344480-6tcush4w 19 15 deaths death NNS cord-344480-6tcush4w 19 16 reported report VBN cord-344480-6tcush4w 19 17 by by IN cord-344480-6tcush4w 19 18 February February NNP cord-344480-6tcush4w 19 19 21 21 CD cord-344480-6tcush4w 19 20 [ [ -LRB- cord-344480-6tcush4w 19 21 8 8 CD cord-344480-6tcush4w 19 22 ] ] -RRB- cord-344480-6tcush4w 19 23 . . . cord-344480-6tcush4w 20 1 By by IN cord-344480-6tcush4w 20 2 February February NNP cord-344480-6tcush4w 20 3 21 21 CD cord-344480-6tcush4w 20 4 , , , cord-344480-6tcush4w 20 5 severe severe JJ cord-344480-6tcush4w 20 6 cases case NNS cord-344480-6tcush4w 20 7 in in IN cord-344480-6tcush4w 20 8 Wuhan Wuhan NNP cord-344480-6tcush4w 20 9 , , , cord-344480-6tcush4w 20 10 other other JJ cord-344480-6tcush4w 20 11 regions region NNS cord-344480-6tcush4w 20 12 of of IN cord-344480-6tcush4w 20 13 China China NNP cord-344480-6tcush4w 20 14 , , , cord-344480-6tcush4w 20 15 and and CC cord-344480-6tcush4w 20 16 the the DT cord-344480-6tcush4w 20 17 whole whole JJ cord-344480-6tcush4w 20 18 country country NN cord-344480-6tcush4w 20 19 were be VBD cord-344480-6tcush4w 20 20 9628 9628 CD cord-344480-6tcush4w 20 21 ( ( -LRB- cord-344480-6tcush4w 20 22 21.2 21.2 CD cord-344480-6tcush4w 20 23 % % NN cord-344480-6tcush4w 20 24 ) ) -RRB- cord-344480-6tcush4w 20 25 , , , cord-344480-6tcush4w 20 26 2005 2005 CD cord-344480-6tcush4w 20 27 ( ( -LRB- cord-344480-6tcush4w 20 28 6.6 6.6 CD cord-344480-6tcush4w 20 29 % % NN cord-344480-6tcush4w 20 30 ) ) -RRB- cord-344480-6tcush4w 20 31 , , , cord-344480-6tcush4w 20 32 and and CC cord-344480-6tcush4w 20 33 11633 11633 CD cord-344480-6tcush4w 20 34 ( ( -LRB- cord-344480-6tcush4w 20 35 15.4 15.4 CD cord-344480-6tcush4w 20 36 % % NN cord-344480-6tcush4w 20 37 ) ) -RRB- cord-344480-6tcush4w 20 38 , , , cord-344480-6tcush4w 20 39 respectively respectively RB cord-344480-6tcush4w 20 40 ( ( -LRB- cord-344480-6tcush4w 20 41 Table table NN cord-344480-6tcush4w 20 42 1 1 CD cord-344480-6tcush4w 20 43 ) ) -RRB- cord-344480-6tcush4w 20 44 . . . cord-344480-6tcush4w 21 1 The the DT cord-344480-6tcush4w 21 2 reproduction reproduction NN cord-344480-6tcush4w 21 3 number number NN cord-344480-6tcush4w 21 4 ( ( -LRB- cord-344480-6tcush4w 21 5 R r NN cord-344480-6tcush4w 21 6 0 0 CD cord-344480-6tcush4w 21 7 ) ) -RRB- cord-344480-6tcush4w 21 8 is be VBZ cord-344480-6tcush4w 21 9 between between IN cord-344480-6tcush4w 21 10 2.2 2.2 CD cord-344480-6tcush4w 21 11 and and CC cord-344480-6tcush4w 21 12 4.8 4.8 CD cord-344480-6tcush4w 21 13 [ [ -LRB- cord-344480-6tcush4w 21 14 9 9 CD cord-344480-6tcush4w 21 15 , , , cord-344480-6tcush4w 21 16 10 10 CD cord-344480-6tcush4w 21 17 ] ] -RRB- cord-344480-6tcush4w 21 18 . . . cord-344480-6tcush4w 22 1 The the DT cord-344480-6tcush4w 22 2 commonest common JJS cord-344480-6tcush4w 22 3 symptoms symptom NNS cord-344480-6tcush4w 22 4 of of IN cord-344480-6tcush4w 22 5 the the DT cord-344480-6tcush4w 22 6 COVID-19 COVID-19 NNP cord-344480-6tcush4w 22 7 include include VBP cord-344480-6tcush4w 22 8 fever fever NN cord-344480-6tcush4w 22 9 , , , cord-344480-6tcush4w 22 10 dry dry JJ cord-344480-6tcush4w 22 11 cough cough NN cord-344480-6tcush4w 22 12 , , , cord-344480-6tcush4w 22 13 fatigue fatigue NN cord-344480-6tcush4w 22 14 , , , cord-344480-6tcush4w 22 15 sputum sputum NN cord-344480-6tcush4w 22 16 , , , cord-344480-6tcush4w 22 17 and and CC cord-344480-6tcush4w 22 18 shortness shortness NN cord-344480-6tcush4w 22 19 of of IN cord-344480-6tcush4w 22 20 breath breath NN cord-344480-6tcush4w 22 21 , , , cord-344480-6tcush4w 22 22 with with IN cord-344480-6tcush4w 22 23 a a DT cord-344480-6tcush4w 22 24 small small JJ cord-344480-6tcush4w 22 25 proportion proportion NN cord-344480-6tcush4w 22 26 of of IN cord-344480-6tcush4w 22 27 patients patient NNS cord-344480-6tcush4w 22 28 ( ( -LRB- cord-344480-6tcush4w 22 29 889/72 889/72 CD cord-344480-6tcush4w 22 30 314 314 CD cord-344480-6tcush4w 22 31 , , , cord-344480-6tcush4w 22 32 1.2 1.2 CD cord-344480-6tcush4w 22 33 % % NN cord-344480-6tcush4w 22 34 ) ) -RRB- cord-344480-6tcush4w 22 35 as as IN cord-344480-6tcush4w 22 36 asymptomatic asymptomatic JJ cord-344480-6tcush4w 22 37 and and CC cord-344480-6tcush4w 22 38 probably probably RB cord-344480-6tcush4w 22 39 spreaders spreader NNS cord-344480-6tcush4w 22 40 [ [ -LRB- cord-344480-6tcush4w 22 41 7 7 CD cord-344480-6tcush4w 22 42 ] ] -RRB- cord-344480-6tcush4w 22 43 . . . cord-344480-6tcush4w 23 1 Cytokine cytokine NN cord-344480-6tcush4w 23 2 storm storm NN cord-344480-6tcush4w 23 3 that that WDT cord-344480-6tcush4w 23 4 is be VBZ cord-344480-6tcush4w 23 5 induced induce VBN cord-344480-6tcush4w 23 6 by by IN cord-344480-6tcush4w 23 7 virus virus NN cord-344480-6tcush4w 23 8 particles particle NNS cord-344480-6tcush4w 23 9 , , , cord-344480-6tcush4w 23 10 is be VBZ cord-344480-6tcush4w 23 11 associated associate VBN cord-344480-6tcush4w 23 12 with with IN cord-344480-6tcush4w 23 13 disease disease NN cord-344480-6tcush4w 23 14 severity severity NN cord-344480-6tcush4w 23 15 [ [ -LRB- cord-344480-6tcush4w 23 16 11 11 CD cord-344480-6tcush4w 23 17 , , , cord-344480-6tcush4w 23 18 12 12 CD cord-344480-6tcush4w 23 19 ] ] -RRB- cord-344480-6tcush4w 23 20 . . . cord-344480-6tcush4w 24 1 A a DT cord-344480-6tcush4w 24 2 first first JJ cord-344480-6tcush4w 24 3 histological histological JJ cord-344480-6tcush4w 24 4 examination examination NN cord-344480-6tcush4w 24 5 of of IN cord-344480-6tcush4w 24 6 COVID-19 covid-19 JJ cord-344480-6tcush4w 24 7 patient patient NN cord-344480-6tcush4w 24 8 showed show VBD cord-344480-6tcush4w 24 9 diffuse diffuse JJ cord-344480-6tcush4w 24 10 alveolar alveolar JJ cord-344480-6tcush4w 24 11 damage damage NN cord-344480-6tcush4w 24 12 with with IN cord-344480-6tcush4w 24 13 cellular cellular JJ cord-344480-6tcush4w 24 14 fibromyxoid fibromyxoid NN cord-344480-6tcush4w 24 15 exudates exudate NNS cord-344480-6tcush4w 24 16 , , , cord-344480-6tcush4w 24 17 desquamation desquamation NN cord-344480-6tcush4w 24 18 of of IN cord-344480-6tcush4w 24 19 pneumocytes pneumocyte NNS cord-344480-6tcush4w 24 20 and and CC cord-344480-6tcush4w 24 21 hyaline hyaline JJ cord-344480-6tcush4w 24 22 membrane membrane NN cord-344480-6tcush4w 24 23 formation formation NN cord-344480-6tcush4w 24 24 , , , cord-344480-6tcush4w 24 25 pulmonary pulmonary JJ cord-344480-6tcush4w 24 26 edema edema NN cord-344480-6tcush4w 24 27 with with IN cord-344480-6tcush4w 24 28 hyaline hyaline JJ cord-344480-6tcush4w 24 29 membrane membrane NN cord-344480-6tcush4w 24 30 formation formation NN cord-344480-6tcush4w 24 31 , , , cord-344480-6tcush4w 24 32 interstitial interstitial JJ cord-344480-6tcush4w 24 33 mononuclear mononuclear JJ cord-344480-6tcush4w 24 34 inflammatory inflammatory JJ cord-344480-6tcush4w 24 35 infiltrates infiltrate NNS cord-344480-6tcush4w 24 36 , , , cord-344480-6tcush4w 24 37 and and CC cord-344480-6tcush4w 24 38 multinucleated multinucleate VBN cord-344480-6tcush4w 24 39 syncytial syncytial JJ cord-344480-6tcush4w 24 40 cells cell NNS cord-344480-6tcush4w 24 41 with with IN cord-344480-6tcush4w 24 42 atypical atypical JJ cord-344480-6tcush4w 24 43 enlarged enlarged JJ cord-344480-6tcush4w 24 44 pneumocytes pneumocyte NNS cord-344480-6tcush4w 24 45 in in IN cord-344480-6tcush4w 24 46 the the DT cord-344480-6tcush4w 24 47 lungs lung NNS cord-344480-6tcush4w 24 48 [ [ -LRB- cord-344480-6tcush4w 24 49 13 13 CD cord-344480-6tcush4w 24 50 ] ] -RRB- cord-344480-6tcush4w 24 51 . . . cord-344480-6tcush4w 25 1 These these DT cord-344480-6tcush4w 25 2 results result NNS cord-344480-6tcush4w 25 3 shed shed VBP cord-344480-6tcush4w 25 4 insights insight NNS cord-344480-6tcush4w 25 5 into into IN cord-344480-6tcush4w 25 6 the the DT cord-344480-6tcush4w 25 7 pathogenesis pathogenesis NN cord-344480-6tcush4w 25 8 of of IN cord-344480-6tcush4w 25 9 COVID-19 COVID-19 NNP cord-344480-6tcush4w 25 10 and and CC cord-344480-6tcush4w 25 11 may may MD cord-344480-6tcush4w 25 12 help help VB cord-344480-6tcush4w 25 13 design design VB cord-344480-6tcush4w 25 14 therapeutic therapeutic JJ cord-344480-6tcush4w 25 15 strategies strategy NNS cord-344480-6tcush4w 25 16 against against IN cord-344480-6tcush4w 25 17 the the DT cord-344480-6tcush4w 25 18 disease disease NN cord-344480-6tcush4w 25 19 . . . cord-344480-6tcush4w 26 1 A a DT cord-344480-6tcush4w 26 2 previously previously RB cord-344480-6tcush4w 26 3 unknown unknown JJ cord-344480-6tcush4w 26 4 betacoronavirus betacoronavirus NN cord-344480-6tcush4w 26 5 was be VBD cord-344480-6tcush4w 26 6 discovered discover VBN cord-344480-6tcush4w 26 7 from from IN cord-344480-6tcush4w 26 8 bronchoalveolar bronchoalveolar JJ cord-344480-6tcush4w 26 9 - - HYPH cord-344480-6tcush4w 26 10 lavage lavage NN cord-344480-6tcush4w 26 11 fluid fluid NN cord-344480-6tcush4w 26 12 samples sample NNS cord-344480-6tcush4w 26 13 of of IN cord-344480-6tcush4w 26 14 the the DT cord-344480-6tcush4w 26 15 patients patient NNS cord-344480-6tcush4w 26 16 , , , cord-344480-6tcush4w 26 17 which which WDT cord-344480-6tcush4w 26 18 is be VBZ cord-344480-6tcush4w 26 19 the the DT cord-344480-6tcush4w 26 20 seventh seventh JJ cord-344480-6tcush4w 26 21 member member NN cord-344480-6tcush4w 26 22 of of IN cord-344480-6tcush4w 26 23 the the DT cord-344480-6tcush4w 26 24 family family NN cord-344480-6tcush4w 26 25 of of IN cord-344480-6tcush4w 26 26 coronaviruses coronaviruse NNS cord-344480-6tcush4w 26 27 that that WDT cord-344480-6tcush4w 26 28 infect infect VBP cord-344480-6tcush4w 26 29 humans human NNS cord-344480-6tcush4w 26 30 [ [ -LRB- cord-344480-6tcush4w 26 31 1 1 CD cord-344480-6tcush4w 26 32 , , , cord-344480-6tcush4w 26 33 14 14 CD cord-344480-6tcush4w 26 34 ] ] -RRB- cord-344480-6tcush4w 26 35 . . . cord-344480-6tcush4w 27 1 The the DT cord-344480-6tcush4w 27 2 virus virus NN cord-344480-6tcush4w 27 3 was be VBD cord-344480-6tcush4w 27 4 most most RBS cord-344480-6tcush4w 27 5 closely closely RB cord-344480-6tcush4w 27 6 related related JJ cord-344480-6tcush4w 27 7 to to IN cord-344480-6tcush4w 27 8 a a DT cord-344480-6tcush4w 27 9 group group NN cord-344480-6tcush4w 27 10 of of IN cord-344480-6tcush4w 27 11 SARS SARS NNP cord-344480-6tcush4w 27 12 - - HYPH cord-344480-6tcush4w 27 13 like like JJ cord-344480-6tcush4w 27 14 coronaviruses coronaviruse NNS cord-344480-6tcush4w 27 15 ( ( -LRB- cord-344480-6tcush4w 27 16 genus genus NN cord-344480-6tcush4w 27 17 Betacoronavirus Betacoronavirus NNP cord-344480-6tcush4w 27 18 , , , cord-344480-6tcush4w 27 19 subgenus subgenu VBN cord-344480-6tcush4w 27 20 Sarbecovirus Sarbecovirus NNP cord-344480-6tcush4w 27 21 ) ) -RRB- cord-344480-6tcush4w 27 22 previously previously RB cord-344480-6tcush4w 27 23 sampled sample VBN cord-344480-6tcush4w 27 24 from from IN cord-344480-6tcush4w 27 25 bats bat NNS cord-344480-6tcush4w 27 26 in in IN cord-344480-6tcush4w 27 27 China China NNP cord-344480-6tcush4w 27 28 [ [ -LRB- cord-344480-6tcush4w 27 29 14 14 CD cord-344480-6tcush4w 27 30 , , , cord-344480-6tcush4w 27 31 15 15 CD cord-344480-6tcush4w 27 32 ] ] -RRB- cord-344480-6tcush4w 27 33 , , , cord-344480-6tcush4w 27 34 and and CC cord-344480-6tcush4w 27 35 a a DT cord-344480-6tcush4w 27 36 virus virus NN cord-344480-6tcush4w 27 37 with with IN cord-344480-6tcush4w 27 38 99 99 CD cord-344480-6tcush4w 27 39 % % NN cord-344480-6tcush4w 27 40 sequence sequence NN cord-344480-6tcush4w 27 41 homology homology NN cord-344480-6tcush4w 27 42 to to IN cord-344480-6tcush4w 27 43 the the DT cord-344480-6tcush4w 27 44 receptor receptor NN cord-344480-6tcush4w 27 45 - - HYPH cord-344480-6tcush4w 27 46 binding bind VBG cord-344480-6tcush4w 27 47 domain domain NN cord-344480-6tcush4w 27 48 ( ( -LRB- cord-344480-6tcush4w 27 49 RBD RBD NNP cord-344480-6tcush4w 27 50 ) ) -RRB- cord-344480-6tcush4w 27 51 and and CC cord-344480-6tcush4w 27 52 90 90 CD cord-344480-6tcush4w 27 53 % % NN cord-344480-6tcush4w 27 54 to to IN cord-344480-6tcush4w 27 55 the the DT cord-344480-6tcush4w 27 56 SARS SARS NNP cord-344480-6tcush4w 27 57 - - HYPH cord-344480-6tcush4w 27 58 CoV-2 CoV-2 NNP cord-344480-6tcush4w 27 59 genome genome NN cord-344480-6tcush4w 27 60 was be VBD cord-344480-6tcush4w 27 61 also also RB cord-344480-6tcush4w 27 62 found find VBN cord-344480-6tcush4w 27 63 in in IN cord-344480-6tcush4w 27 64 Malayan Malayan NNP cord-344480-6tcush4w 27 65 pangolins pangolin NNS cord-344480-6tcush4w 27 66 in in IN cord-344480-6tcush4w 27 67 southern southern JJ cord-344480-6tcush4w 27 68 China China NNP cord-344480-6tcush4w 27 69 [ [ -LRB- cord-344480-6tcush4w 27 70 16 16 CD cord-344480-6tcush4w 27 71 ] ] -RRB- cord-344480-6tcush4w 27 72 . . . cord-344480-6tcush4w 28 1 However however RB cord-344480-6tcush4w 28 2 , , , cord-344480-6tcush4w 28 3 higher high JJR cord-344480-6tcush4w 28 4 viral viral JJ cord-344480-6tcush4w 28 5 loads load NNS cord-344480-6tcush4w 28 6 were be VBD cord-344480-6tcush4w 28 7 detected detect VBN cord-344480-6tcush4w 28 8 in in IN cord-344480-6tcush4w 28 9 the the DT cord-344480-6tcush4w 28 10 nose nose NN cord-344480-6tcush4w 28 11 than than IN cord-344480-6tcush4w 28 12 in in IN cord-344480-6tcush4w 28 13 the the DT cord-344480-6tcush4w 28 14 throat throat NN cord-344480-6tcush4w 28 15 of of IN cord-344480-6tcush4w 28 16 symptomatic symptomatic JJ cord-344480-6tcush4w 28 17 and and CC cord-344480-6tcush4w 28 18 asymptomatic asymptomatic JJ cord-344480-6tcush4w 28 19 COVID-19 COVID-19 NNP cord-344480-6tcush4w 28 20 , , , cord-344480-6tcush4w 28 21 a a DT cord-344480-6tcush4w 28 22 pattern pattern NN cord-344480-6tcush4w 28 23 resembling resemble VBG cord-344480-6tcush4w 28 24 that that DT cord-344480-6tcush4w 28 25 of of IN cord-344480-6tcush4w 28 26 influenza influenza NN cord-344480-6tcush4w 28 27 but but CC cord-344480-6tcush4w 28 28 not not RB cord-344480-6tcush4w 28 29 SARS SARS NNP cord-344480-6tcush4w 28 30 - - HYPH cord-344480-6tcush4w 28 31 CoV CoV NNP cord-344480-6tcush4w 28 32 [ [ -LRB- cord-344480-6tcush4w 28 33 17 17 CD cord-344480-6tcush4w 28 34 ] ] -RRB- cord-344480-6tcush4w 28 35 . . . cord-344480-6tcush4w 29 1 Human human JJ cord-344480-6tcush4w 29 2 angiotensin angiotensin NN cord-344480-6tcush4w 29 3 - - HYPH cord-344480-6tcush4w 29 4 converting convert VBG cord-344480-6tcush4w 29 5 enzyme enzyme NN cord-344480-6tcush4w 29 6 2 2 CD cord-344480-6tcush4w 29 7 ( ( -LRB- cord-344480-6tcush4w 29 8 ACE2 ACE2 NNP cord-344480-6tcush4w 29 9 ) ) -RRB- cord-344480-6tcush4w 29 10 has have VBZ cord-344480-6tcush4w 29 11 been be VBN cord-344480-6tcush4w 29 12 shown show VBN cord-344480-6tcush4w 29 13 to to TO cord-344480-6tcush4w 29 14 be be VB cord-344480-6tcush4w 29 15 the the DT cord-344480-6tcush4w 29 16 putative putative JJ cord-344480-6tcush4w 29 17 receptor receptor NN cord-344480-6tcush4w 29 18 for for IN cord-344480-6tcush4w 29 19 the the DT cord-344480-6tcush4w 29 20 virus virus NN cord-344480-6tcush4w 29 21 to to TO cord-344480-6tcush4w 29 22 enter enter VB cord-344480-6tcush4w 29 23 into into IN cord-344480-6tcush4w 29 24 host host NN cord-344480-6tcush4w 29 25 cells cell NNS cord-344480-6tcush4w 29 26 [ [ -LRB- cord-344480-6tcush4w 29 27 15 15 CD cord-344480-6tcush4w 29 28 , , , cord-344480-6tcush4w 29 29 18 18 CD cord-344480-6tcush4w 29 30 ] ] -RRB- cord-344480-6tcush4w 29 31 , , , cord-344480-6tcush4w 29 32 and and CC cord-344480-6tcush4w 29 33 biophysical biophysical JJ cord-344480-6tcush4w 29 34 and and CC cord-344480-6tcush4w 29 35 structural structural JJ cord-344480-6tcush4w 29 36 evidence evidence NN cord-344480-6tcush4w 29 37 shows show VBZ cord-344480-6tcush4w 29 38 that that IN cord-344480-6tcush4w 29 39 the the DT cord-344480-6tcush4w 29 40 SARS SARS NNP cord-344480-6tcush4w 29 41 - - HYPH cord-344480-6tcush4w 29 42 CoV-2 CoV-2 NNP cord-344480-6tcush4w 29 43 spike spike NN cord-344480-6tcush4w 29 44 glycoprotein glycoprotein NN cord-344480-6tcush4w 29 45 binds bind VBZ cord-344480-6tcush4w 29 46 ACE2 ACE2 NNP cord-344480-6tcush4w 29 47 with with IN cord-344480-6tcush4w 29 48 high high JJ cord-344480-6tcush4w 29 49 affinity affinity NN cord-344480-6tcush4w 29 50 [ [ -LRB- cord-344480-6tcush4w 29 51 19 19 CD cord-344480-6tcush4w 29 52 ] ] -RRB- cord-344480-6tcush4w 29 53 . . . cord-344480-6tcush4w 30 1 ACE2 ACE2 NNP cord-344480-6tcush4w 30 2 can can MD cord-344480-6tcush4w 30 3 also also RB cord-344480-6tcush4w 30 4 bind bind VB cord-344480-6tcush4w 30 5 spike spike NN cord-344480-6tcush4w 30 6 protein protein NN cord-344480-6tcush4w 30 7 through through IN cord-344480-6tcush4w 30 8 association association NN cord-344480-6tcush4w 30 9 with with IN cord-344480-6tcush4w 30 10 B0AT1 B0AT1 NNP cord-344480-6tcush4w 30 11 [ [ -LRB- cord-344480-6tcush4w 30 12 20 20 CD cord-344480-6tcush4w 30 13 ] ] -RRB- cord-344480-6tcush4w 30 14 . . . cord-344480-6tcush4w 31 1 ACE2 ACE2 NNP cord-344480-6tcush4w 31 2 locates locate VBZ cord-344480-6tcush4w 31 3 on on IN cord-344480-6tcush4w 31 4 the the DT cord-344480-6tcush4w 31 5 organs organ NNS cord-344480-6tcush4w 31 6 such such JJ cord-344480-6tcush4w 31 7 as as IN cord-344480-6tcush4w 31 8 lung lung NN cord-344480-6tcush4w 31 9 , , , cord-344480-6tcush4w 31 10 heart heart NN cord-344480-6tcush4w 31 11 , , , cord-344480-6tcush4w 31 12 esophagus esophagus NN cord-344480-6tcush4w 31 13 , , , cord-344480-6tcush4w 31 14 kidney kidney NN cord-344480-6tcush4w 31 15 , , , cord-344480-6tcush4w 31 16 bladder bladder NN cord-344480-6tcush4w 31 17 and and CC cord-344480-6tcush4w 31 18 ileum ileum NN cord-344480-6tcush4w 31 19 , , , cord-344480-6tcush4w 31 20 and and CC cord-344480-6tcush4w 31 21 in in IN cord-344480-6tcush4w 31 22 particular particular JJ cord-344480-6tcush4w 31 23 on on IN cord-344480-6tcush4w 31 24 the the DT cord-344480-6tcush4w 31 25 cell cell NN cord-344480-6tcush4w 31 26 types type NNS cord-344480-6tcush4w 31 27 such such JJ cord-344480-6tcush4w 31 28 as as IN cord-344480-6tcush4w 31 29 type type NN cord-344480-6tcush4w 31 30 II ii CD cord-344480-6tcush4w 31 31 alveolar alveolar NN cord-344480-6tcush4w 31 32 cells cell NNS cord-344480-6tcush4w 31 33 , , , cord-344480-6tcush4w 31 34 myocardial myocardial JJ cord-344480-6tcush4w 31 35 cells cell NNS cord-344480-6tcush4w 31 36 , , , cord-344480-6tcush4w 31 37 proximal proximal JJ cord-344480-6tcush4w 31 38 tubule tubule NN cord-344480-6tcush4w 31 39 cells cell NNS cord-344480-6tcush4w 31 40 of of IN cord-344480-6tcush4w 31 41 kidney kidney NN cord-344480-6tcush4w 31 42 , , , cord-344480-6tcush4w 31 43 ileum ileum NN cord-344480-6tcush4w 31 44 and and CC cord-344480-6tcush4w 31 45 esophagus esophagus NN cord-344480-6tcush4w 31 46 epithelial epithelial JJ cord-344480-6tcush4w 31 47 cells cell NNS cord-344480-6tcush4w 31 48 , , , cord-344480-6tcush4w 31 49 and and CC cord-344480-6tcush4w 31 50 bladder bladder NN cord-344480-6tcush4w 31 51 urothelial urothelial JJ cord-344480-6tcush4w 31 52 cells cell NNS cord-344480-6tcush4w 31 53 , , , cord-344480-6tcush4w 31 54 providing provide VBG cord-344480-6tcush4w 31 55 clues clue NNS cord-344480-6tcush4w 31 56 for for IN cord-344480-6tcush4w 31 57 further further RB cord-344480-6tcush4w 31 58 investigating investigate VBG cord-344480-6tcush4w 31 59 the the DT cord-344480-6tcush4w 31 60 pathogenesis pathogenesis NN cord-344480-6tcush4w 31 61 COVID-19 covid-19 CD cord-344480-6tcush4w 31 62 [ [ -LRB- cord-344480-6tcush4w 31 63 21 21 CD cord-344480-6tcush4w 31 64 ] ] -RRB- cord-344480-6tcush4w 31 65 . . . cord-344480-6tcush4w 32 1 So so RB cord-344480-6tcush4w 32 2 far far RB cord-344480-6tcush4w 32 3 , , , cord-344480-6tcush4w 32 4 neither neither CC cord-344480-6tcush4w 32 5 drug drug NN cord-344480-6tcush4w 32 6 nor nor CC cord-344480-6tcush4w 32 7 vaccine vaccine NN cord-344480-6tcush4w 32 8 has have VBZ cord-344480-6tcush4w 32 9 been be VBN cord-344480-6tcush4w 32 10 approved approve VBN cord-344480-6tcush4w 32 11 to to TO cord-344480-6tcush4w 32 12 treat treat VB cord-344480-6tcush4w 32 13 the the DT cord-344480-6tcush4w 32 14 novel novel NN cord-344480-6tcush4w 32 15 COVID-19 covid-19 NN cord-344480-6tcush4w 32 16 . . . cord-344480-6tcush4w 33 1 While while IN cord-344480-6tcush4w 33 2 supportive supportive JJ cord-344480-6tcush4w 33 3 treatment treatment NN cord-344480-6tcush4w 33 4 regimens regimen NNS cord-344480-6tcush4w 33 5 including include VBG cord-344480-6tcush4w 33 6 oxygen oxygen NN cord-344480-6tcush4w 33 7 therapy therapy NN cord-344480-6tcush4w 33 8 are be VBP cord-344480-6tcush4w 33 9 widely widely RB cord-344480-6tcush4w 33 10 used use VBN cord-344480-6tcush4w 33 11 , , , cord-344480-6tcush4w 33 12 antivirus antivirus JJ cord-344480-6tcush4w 33 13 ( ( -LRB- cord-344480-6tcush4w 33 14 oseltamivir oseltamivir NNP cord-344480-6tcush4w 33 15 ) ) -RRB- cord-344480-6tcush4w 33 16 and and CC cord-344480-6tcush4w 33 17 anti anti JJ cord-344480-6tcush4w 33 18 - - JJ cord-344480-6tcush4w 33 19 HIV HIV NNP cord-344480-6tcush4w 33 20 ( ( -LRB- cord-344480-6tcush4w 33 21 lopinavir lopinavir NNP cord-344480-6tcush4w 33 22 / / SYM cord-344480-6tcush4w 33 23 ritonavir ritonavir NNP cord-344480-6tcush4w 33 24 ) ) -RRB- cord-344480-6tcush4w 34 1 drugs drug NNS cord-344480-6tcush4w 34 2 are be VBP cord-344480-6tcush4w 34 3 also also RB cord-344480-6tcush4w 34 4 applied apply VBN cord-344480-6tcush4w 34 5 in in IN cord-344480-6tcush4w 34 6 treating treat VBG cord-344480-6tcush4w 34 7 COVID-19 covid-19 NN cord-344480-6tcush4w 34 8 . . . cord-344480-6tcush4w 35 1 Some some DT cord-344480-6tcush4w 35 2 emerging emerge VBG cord-344480-6tcush4w 35 3 therapeutics therapeutic NNS cord-344480-6tcush4w 35 4 are be VBP cord-344480-6tcush4w 35 5 being be VBG cord-344480-6tcush4w 35 6 tested test VBN cord-344480-6tcush4w 35 7 in in IN cord-344480-6tcush4w 35 8 clinical clinical JJ cord-344480-6tcush4w 35 9 trials trial NNS cord-344480-6tcush4w 35 10 . . . cord-344480-6tcush4w 36 1 For for IN cord-344480-6tcush4w 36 2 example example NN cord-344480-6tcush4w 36 3 , , , cord-344480-6tcush4w 36 4 virally virally RB cord-344480-6tcush4w 36 5 targeted target VBN cord-344480-6tcush4w 36 6 agents agent NNS cord-344480-6tcush4w 36 7 , , , cord-344480-6tcush4w 36 8 approved approve VBN cord-344480-6tcush4w 36 9 nucleoside nucleoside JJ cord-344480-6tcush4w 36 10 analogs analogs NNP cord-344480-6tcush4w 36 11 ( ( -LRB- cord-344480-6tcush4w 36 12 favipiravir favipiravir NNP cord-344480-6tcush4w 36 13 and and CC cord-344480-6tcush4w 36 14 ribavirin ribavirin NN cord-344480-6tcush4w 36 15 ) ) -RRB- cord-344480-6tcush4w 36 16 and and CC cord-344480-6tcush4w 36 17 experimental experimental JJ cord-344480-6tcush4w 36 18 nucleoside nucleoside NN cord-344480-6tcush4w 36 19 analogs analog NNS cord-344480-6tcush4w 36 20 ( ( -LRB- cord-344480-6tcush4w 36 21 remdesivir remdesivir NNP cord-344480-6tcush4w 36 22 and and CC cord-344480-6tcush4w 36 23 galidesivir galidesivir NNP cord-344480-6tcush4w 36 24 ) ) -RRB- cord-344480-6tcush4w 36 25 , , , cord-344480-6tcush4w 36 26 may may MD cord-344480-6tcush4w 36 27 have have VB cord-344480-6tcush4w 36 28 potentials potential NNS cord-344480-6tcush4w 36 29 against against IN cord-344480-6tcush4w 36 30 SARS SARS NNP cord-344480-6tcush4w 36 31 - - HYPH cord-344480-6tcush4w 36 32 CoV-2 CoV-2 NNP cord-344480-6tcush4w 36 33 [ [ -LRB- cord-344480-6tcush4w 36 34 22 22 CD cord-344480-6tcush4w 36 35 ] ] -RRB- cord-344480-6tcush4w 36 36 . . . cord-344480-6tcush4w 37 1 Remdesivir Remdesivir NNP cord-344480-6tcush4w 37 2 has have VBZ cord-344480-6tcush4w 37 3 been be VBN cord-344480-6tcush4w 37 4 shown show VBN cord-344480-6tcush4w 37 5 to to TO cord-344480-6tcush4w 37 6 be be VB cord-344480-6tcush4w 37 7 able able JJ cord-344480-6tcush4w 37 8 to to TO cord-344480-6tcush4w 37 9 block block VB cord-344480-6tcush4w 37 10 virus virus NN cord-344480-6tcush4w 37 11 infection infection NN cord-344480-6tcush4w 37 12 [ [ -LRB- cord-344480-6tcush4w 37 13 23 23 CD cord-344480-6tcush4w 37 14 ] ] -RRB- cord-344480-6tcush4w 37 15 and and CC cord-344480-6tcush4w 37 16 exert exert VB cord-344480-6tcush4w 37 17 therapeutic therapeutic JJ cord-344480-6tcush4w 37 18 efficacy efficacy NN cord-344480-6tcush4w 37 19 in in IN cord-344480-6tcush4w 37 20 the the DT cord-344480-6tcush4w 37 21 first first JJ cord-344480-6tcush4w 37 22 COVID-19 COVID-19 NNP cord-344480-6tcush4w 37 23 case case NN cord-344480-6tcush4w 37 24 in in IN cord-344480-6tcush4w 37 25 the the DT cord-344480-6tcush4w 37 26 United United NNP cord-344480-6tcush4w 37 27 States States NNP cord-344480-6tcush4w 37 28 [ [ -LRB- cord-344480-6tcush4w 37 29 24 24 CD cord-344480-6tcush4w 37 30 ] ] -RRB- cord-344480-6tcush4w 37 31 . . . cord-344480-6tcush4w 38 1 Two two CD cord-344480-6tcush4w 38 2 phase phase NN cord-344480-6tcush4w 38 3 III iii CD cord-344480-6tcush4w 38 4 trials trial NNS cord-344480-6tcush4w 38 5 have have VBP cord-344480-6tcush4w 38 6 been be VBN cord-344480-6tcush4w 38 7 initiated initiate VBN cord-344480-6tcush4w 38 8 to to TO cord-344480-6tcush4w 38 9 evaluate evaluate VB cord-344480-6tcush4w 38 10 remdesivir remdesivir NNP cord-344480-6tcush4w 38 11 in in IN cord-344480-6tcush4w 38 12 COVID-19 COVID-19 NNP cord-344480-6tcush4w 38 13 . . . cord-344480-6tcush4w 39 1 Anti anti JJ cord-344480-6tcush4w 39 2 - - JJ cord-344480-6tcush4w 39 3 malaria malaria JJ cord-344480-6tcush4w 39 4 drug drug NN cord-344480-6tcush4w 39 5 chloroquine chloroquine NN cord-344480-6tcush4w 39 6 shows show VBZ cord-344480-6tcush4w 39 7 activity activity NN cord-344480-6tcush4w 39 8 in in IN cord-344480-6tcush4w 39 9 blocking block VBG cord-344480-6tcush4w 39 10 SARS SARS NNP cord-344480-6tcush4w 39 11 - - HYPH cord-344480-6tcush4w 39 12 CoV-2 CoV-2 NNP cord-344480-6tcush4w 39 13 infection infection NN cord-344480-6tcush4w 39 14 [ [ -LRB- cord-344480-6tcush4w 39 15 23 23 CD cord-344480-6tcush4w 39 16 ] ] -RRB- cord-344480-6tcush4w 39 17 and and CC cord-344480-6tcush4w 39 18 is be VBZ cord-344480-6tcush4w 39 19 being be VBG cord-344480-6tcush4w 39 20 evaluated evaluate VBN cord-344480-6tcush4w 39 21 in in IN cord-344480-6tcush4w 39 22 an an DT cord-344480-6tcush4w 39 23 open open JJ cord-344480-6tcush4w 39 24 - - HYPH cord-344480-6tcush4w 39 25 label label NN cord-344480-6tcush4w 39 26 trial trial NN cord-344480-6tcush4w 39 27 [ [ -LRB- cord-344480-6tcush4w 39 28 22 22 CD cord-344480-6tcush4w 39 29 ] ] -RRB- cord-344480-6tcush4w 39 30 . . . cord-344480-6tcush4w 40 1 Convalescent convalescent JJ cord-344480-6tcush4w 40 2 patient patient NN cord-344480-6tcush4w 40 3 plasma plasma NN cord-344480-6tcush4w 40 4 that that WDT cord-344480-6tcush4w 40 5 contain contain VBP cord-344480-6tcush4w 40 6 anti anti JJ cord-344480-6tcush4w 40 7 - - JJ cord-344480-6tcush4w 40 8 SARS SARS NNP cord-344480-6tcush4w 40 9 - - HYPH cord-344480-6tcush4w 40 10 CoV-2 CoV-2 NNP cord-344480-6tcush4w 40 11 antibody antibody NN cord-344480-6tcush4w 40 12 holds hold VBZ cord-344480-6tcush4w 40 13 promise promise NN cord-344480-6tcush4w 40 14 to to TO cord-344480-6tcush4w 40 15 beat beat VB cord-344480-6tcush4w 40 16 this this DT cord-344480-6tcush4w 40 17 disease disease NN cord-344480-6tcush4w 40 18 [ [ -LRB- cord-344480-6tcush4w 40 19 25 25 CD cord-344480-6tcush4w 40 20 ] ] -RRB- cord-344480-6tcush4w 40 21 . . . cord-344480-6tcush4w 41 1 ACE2 ACE2 NNP cord-344480-6tcush4w 41 2 and and CC cord-344480-6tcush4w 41 3 Spike Spike NNP cord-344480-6tcush4w 41 4 protein protein NN cord-344480-6tcush4w 41 5 represent represent VBP cord-344480-6tcush4w 41 6 two two CD cord-344480-6tcush4w 41 7 novel novel JJ cord-344480-6tcush4w 41 8 therapeutic therapeutic JJ cord-344480-6tcush4w 41 9 targets target NNS cord-344480-6tcush4w 41 10 for for IN cord-344480-6tcush4w 41 11 the the DT cord-344480-6tcush4w 41 12 disease disease NN cord-344480-6tcush4w 41 13 [ [ -LRB- cord-344480-6tcush4w 41 14 26 26 CD cord-344480-6tcush4w 41 15 ] ] -RRB- cord-344480-6tcush4w 41 16 . . . cord-344480-6tcush4w 42 1 An an DT cord-344480-6tcush4w 42 2 ongoing ongoing JJ cord-344480-6tcush4w 42 3 study study NN cord-344480-6tcush4w 42 4 using use VBG cord-344480-6tcush4w 42 5 Tocilizumab Tocilizumab NNP cord-344480-6tcush4w 42 6 , , , cord-344480-6tcush4w 42 7 a a DT cord-344480-6tcush4w 42 8 specific specific JJ cord-344480-6tcush4w 42 9 monoclonal monoclonal JJ cord-344480-6tcush4w 42 10 antibody antibody NN cord-344480-6tcush4w 42 11 antagonist antagonist NN cord-344480-6tcush4w 42 12 of of IN cord-344480-6tcush4w 42 13 interleukin-6 interleukin-6 NNP cord-344480-6tcush4w 42 14 receptor receptor NN cord-344480-6tcush4w 42 15 ( ( -LRB- cord-344480-6tcush4w 42 16 IL-6R IL-6R NNP cord-344480-6tcush4w 42 17 ) ) -RRB- cord-344480-6tcush4w 42 18 which which WDT cord-344480-6tcush4w 42 19 proved prove VBD cord-344480-6tcush4w 42 20 to to TO cord-344480-6tcush4w 42 21 be be VB cord-344480-6tcush4w 42 22 effective effective JJ cord-344480-6tcush4w 42 23 in in IN cord-344480-6tcush4w 42 24 alleviating alleviate VBG cord-344480-6tcush4w 42 25 cytokine cytokine NN cord-344480-6tcush4w 42 26 release release NN cord-344480-6tcush4w 42 27 syndrome syndrome NN cord-344480-6tcush4w 42 28 , , , cord-344480-6tcush4w 42 29 showed show VBD cord-344480-6tcush4w 42 30 preliminary preliminary JJ cord-344480-6tcush4w 42 31 positive positive JJ cord-344480-6tcush4w 42 32 effects effect NNS cord-344480-6tcush4w 42 33 [ [ -LRB- cord-344480-6tcush4w 42 34 27 27 CD cord-344480-6tcush4w 42 35 ] ] -RRB- cord-344480-6tcush4w 42 36 . . . cord-344480-6tcush4w 43 1 Traditional traditional JJ cord-344480-6tcush4w 43 2 Chinese chinese JJ cord-344480-6tcush4w 43 3 medicine medicine NN cord-344480-6tcush4w 43 4 ( ( -LRB- cord-344480-6tcush4w 43 5 TCM TCM NNP cord-344480-6tcush4w 43 6 ) ) -RRB- cord-344480-6tcush4w 43 7 plays play VBZ cord-344480-6tcush4w 43 8 an an DT cord-344480-6tcush4w 43 9 active active JJ cord-344480-6tcush4w 43 10 role role NN cord-344480-6tcush4w 43 11 in in IN cord-344480-6tcush4w 43 12 fighting fight VBG cord-344480-6tcush4w 43 13 infectious infectious JJ cord-344480-6tcush4w 43 14 disease disease NN cord-344480-6tcush4w 43 15 , , , cord-344480-6tcush4w 43 16 exemplified exemplify VBN cord-344480-6tcush4w 43 17 by by IN cord-344480-6tcush4w 43 18 ancient ancient JJ cord-344480-6tcush4w 43 19 formula formula NN cord-344480-6tcush4w 43 20 Maxingshigan Maxingshigan NNP cord-344480-6tcush4w 43 21 - - HYPH cord-344480-6tcush4w 43 22 Yinqiaosan Yinqiaosan NNP cord-344480-6tcush4w 43 23 in in IN cord-344480-6tcush4w 43 24 the the DT cord-344480-6tcush4w 43 25 treatment treatment NN cord-344480-6tcush4w 43 26 of of IN cord-344480-6tcush4w 43 27 H1N1 H1N1 NNP cord-344480-6tcush4w 43 28 influenza influenza NN cord-344480-6tcush4w 43 29 [ [ -LRB- cord-344480-6tcush4w 43 30 28 28 CD cord-344480-6tcush4w 43 31 ] ] -RRB- cord-344480-6tcush4w 43 32 . . . cord-344480-6tcush4w 44 1 In in IN cord-344480-6tcush4w 44 2 combination combination NN cord-344480-6tcush4w 44 3 with with IN cord-344480-6tcush4w 44 4 Western western JJ cord-344480-6tcush4w 44 5 medicine medicine NN cord-344480-6tcush4w 44 6 [ [ -LRB- cord-344480-6tcush4w 44 7 29 29 CD cord-344480-6tcush4w 44 8 ] ] -RRB- cord-344480-6tcush4w 44 9 or or CC cord-344480-6tcush4w 44 10 used use VBN cord-344480-6tcush4w 44 11 alone alone RB cord-344480-6tcush4w 44 12 , , , cord-344480-6tcush4w 44 13 TCM TCM NNP cord-344480-6tcush4w 44 14 is be VBZ cord-344480-6tcush4w 44 15 widely widely RB cord-344480-6tcush4w 44 16 applied apply VBN cord-344480-6tcush4w 44 17 or or CC cord-344480-6tcush4w 44 18 being be VBG cord-344480-6tcush4w 44 19 evaluated evaluate VBN cord-344480-6tcush4w 44 20 in in IN cord-344480-6tcush4w 44 21 clinical clinical JJ cord-344480-6tcush4w 44 22 trials trial NNS cord-344480-6tcush4w 44 23 to to TO cord-344480-6tcush4w 44 24 treat treat VB cord-344480-6tcush4w 44 25 COVID-19 COVID-19 NNP cord-344480-6tcush4w 44 26 . . . cord-344480-6tcush4w 45 1 Two two CD cord-344480-6tcush4w 45 2 and and CC cord-344480-6tcush4w 45 3 a a DT cord-344480-6tcush4w 45 4 half half NN cord-344480-6tcush4w 45 5 months month NNS cord-344480-6tcush4w 45 6 have have VBP cord-344480-6tcush4w 45 7 witnessed witness VBN cord-344480-6tcush4w 45 8 the the DT cord-344480-6tcush4w 45 9 great great JJ cord-344480-6tcush4w 45 10 efforts effort NNS cord-344480-6tcush4w 45 11 that that WDT cord-344480-6tcush4w 45 12 China China NNP cord-344480-6tcush4w 45 13 has have VBZ cord-344480-6tcush4w 45 14 been be VBN cord-344480-6tcush4w 45 15 endeavoring endeavor VBG cord-344480-6tcush4w 45 16 to to TO cord-344480-6tcush4w 45 17 control control VB cord-344480-6tcush4w 45 18 the the DT cord-344480-6tcush4w 45 19 outbreak outbreak NN cord-344480-6tcush4w 45 20 of of IN cord-344480-6tcush4w 45 21 the the DT cord-344480-6tcush4w 45 22 COVID-19 covid-19 NN cord-344480-6tcush4w 45 23 . . . cord-344480-6tcush4w 46 1 These these DT cord-344480-6tcush4w 46 2 include include VBP cord-344480-6tcush4w 46 3 lockdown lockdown NN cord-344480-6tcush4w 46 4 of of IN cord-344480-6tcush4w 46 5 Wuhan Wuhan NNP cord-344480-6tcush4w 46 6 and and CC cord-344480-6tcush4w 46 7 related relate VBN cord-344480-6tcush4w 46 8 cities city NNS cord-344480-6tcush4w 46 9 , , , cord-344480-6tcush4w 46 10 control control NN cord-344480-6tcush4w 46 11 of of IN cord-344480-6tcush4w 46 12 population population NN cord-344480-6tcush4w 46 13 mobility mobility NN cord-344480-6tcush4w 46 14 , , , cord-344480-6tcush4w 46 15 and and CC cord-344480-6tcush4w 46 16 input input NN cord-344480-6tcush4w 46 17 of of IN cord-344480-6tcush4w 46 18 huge huge JJ cord-344480-6tcush4w 46 19 resource resource NN cord-344480-6tcush4w 46 20 to to IN cord-344480-6tcush4w 46 21 the the DT cord-344480-6tcush4w 46 22 regions region NNS cord-344480-6tcush4w 46 23 . . . cord-344480-6tcush4w 47 1 China China NNP cord-344480-6tcush4w 47 2 races race NNS cord-344480-6tcush4w 47 3 against against IN cord-344480-6tcush4w 47 4 the the DT cord-344480-6tcush4w 47 5 clock clock NN cord-344480-6tcush4w 47 6 to to TO cord-344480-6tcush4w 47 7 build build VB cord-344480-6tcush4w 47 8 virus virus NN cord-344480-6tcush4w 47 9 hospitals hospital NNS cord-344480-6tcush4w 47 10 , , , cord-344480-6tcush4w 47 11 including include VBG cord-344480-6tcush4w 47 12 Huoshenshan Huoshenshan NNP cord-344480-6tcush4w 47 13 Hospital Hospital NNP cord-344480-6tcush4w 47 14 with with IN cord-344480-6tcush4w 47 15 1000 1000 CD cord-344480-6tcush4w 47 16 beds bed NNS cord-344480-6tcush4w 47 17 built build VBN cord-344480-6tcush4w 47 18 in in IN cord-344480-6tcush4w 47 19 9 9 CD cord-344480-6tcush4w 47 20 days day NNS cord-344480-6tcush4w 47 21 and and CC cord-344480-6tcush4w 47 22 Leishenshan Leishenshan NNP cord-344480-6tcush4w 47 23 Hospital Hospital NNP cord-344480-6tcush4w 47 24 with with IN cord-344480-6tcush4w 47 25 1500 1500 CD cord-344480-6tcush4w 47 26 beds bed NNS cord-344480-6tcush4w 47 27 completed complete VBN cord-344480-6tcush4w 47 28 in in IN cord-344480-6tcush4w 47 29 15 15 CD cord-344480-6tcush4w 47 30 days day NNS cord-344480-6tcush4w 47 31 . . . cord-344480-6tcush4w 48 1 More More JJR cord-344480-6tcush4w 48 2 than than IN cord-344480-6tcush4w 48 3 15 15 CD cord-344480-6tcush4w 48 4 Fangcang Fangcang NNP cord-344480-6tcush4w 48 5 hospitals hospital NNS cord-344480-6tcush4w 48 6 ( ( -LRB- cord-344480-6tcush4w 48 7 with with IN cord-344480-6tcush4w 48 8 large large JJ cord-344480-6tcush4w 48 9 open open JJ cord-344480-6tcush4w 48 10 space space NN cord-344480-6tcush4w 48 11 and and CC cord-344480-6tcush4w 48 12 necessary necessary JJ cord-344480-6tcush4w 48 13 anti anti JJ cord-344480-6tcush4w 48 14 - - JJ cord-344480-6tcush4w 48 15 infection infection JJ cord-344480-6tcush4w 48 16 conditions condition NNS cord-344480-6tcush4w 48 17 ) ) -RRB- cord-344480-6tcush4w 48 18 have have VBP cord-344480-6tcush4w 48 19 been be VBN cord-344480-6tcush4w 48 20 built build VBN cord-344480-6tcush4w 48 21 with with IN cord-344480-6tcush4w 48 22 a a DT cord-344480-6tcush4w 48 23 capacity capacity NN cord-344480-6tcush4w 48 24 of of IN cord-344480-6tcush4w 48 25 more more JJR cord-344480-6tcush4w 48 26 than than IN cord-344480-6tcush4w 48 27 20 20 CD cord-344480-6tcush4w 48 28 000 000 CD cord-344480-6tcush4w 48 29 beds bed NNS cord-344480-6tcush4w 48 30 for for IN cord-344480-6tcush4w 48 31 the the DT cord-344480-6tcush4w 48 32 isolation isolation NN cord-344480-6tcush4w 48 33 and and CC cord-344480-6tcush4w 48 34 treatment treatment NN cord-344480-6tcush4w 48 35 of of IN cord-344480-6tcush4w 48 36 the the DT cord-344480-6tcush4w 48 37 patients patient NNS cord-344480-6tcush4w 48 38 . . . cord-344480-6tcush4w 49 1 The the DT cord-344480-6tcush4w 49 2 updated update VBN cord-344480-6tcush4w 49 3 genome genome NN cord-344480-6tcush4w 49 4 sequence sequence NN cord-344480-6tcush4w 49 5 of of IN cord-344480-6tcush4w 49 6 SARS SARS NNP cord-344480-6tcush4w 49 7 - - HYPH cord-344480-6tcush4w 49 8 CoV-2 CoV-2 NNP cord-344480-6tcush4w 49 9 has have VBZ cord-344480-6tcush4w 49 10 been be VBN cord-344480-6tcush4w 49 11 shared share VBN cord-344480-6tcush4w 49 12 to to IN cord-344480-6tcush4w 49 13 the the DT cord-344480-6tcush4w 49 14 public public JJ cord-344480-6tcush4w 49 15 , , , cord-344480-6tcush4w 49 16 clinical clinical JJ cord-344480-6tcush4w 49 17 trials trial NNS cord-344480-6tcush4w 49 18 are be VBP cord-344480-6tcush4w 49 19 undergoing undergo VBG cord-344480-6tcush4w 49 20 , , , cord-344480-6tcush4w 49 21 and and CC cord-344480-6tcush4w 49 22 scientists scientist NNS cord-344480-6tcush4w 49 23 from from IN cord-344480-6tcush4w 49 24 China China NNP cord-344480-6tcush4w 49 25 and and CC cord-344480-6tcush4w 49 26 overseas overseas RB cord-344480-6tcush4w 49 27 are be VBP cord-344480-6tcush4w 49 28 working work VBG cord-344480-6tcush4w 49 29 together together RB cord-344480-6tcush4w 49 30 to to TO cord-344480-6tcush4w 49 31 combat combat VB cord-344480-6tcush4w 49 32 this this DT cord-344480-6tcush4w 49 33 public public JJ cord-344480-6tcush4w 49 34 health health NN cord-344480-6tcush4w 49 35 emergency emergency NN cord-344480-6tcush4w 49 36 . . . cord-344480-6tcush4w 50 1 With with IN cord-344480-6tcush4w 50 2 great great JJ cord-344480-6tcush4w 50 3 contributions contribution NNS cord-344480-6tcush4w 50 4 of of IN cord-344480-6tcush4w 50 5 our -PRON- PRP$ cord-344480-6tcush4w 50 6 domestic domestic JJ cord-344480-6tcush4w 50 7 selfless selfless JJ cord-344480-6tcush4w 50 8 medical medical JJ cord-344480-6tcush4w 50 9 professionals professional NNS cord-344480-6tcush4w 50 10 and and CC cord-344480-6tcush4w 50 11 supports support NNS cord-344480-6tcush4w 50 12 from from IN cord-344480-6tcush4w 50 13 public public JJ cord-344480-6tcush4w 50 14 health health NN cord-344480-6tcush4w 50 15 scientists scientist NNS cord-344480-6tcush4w 50 16 around around IN cord-344480-6tcush4w 50 17 the the DT cord-344480-6tcush4w 50 18 world world NN cord-344480-6tcush4w 50 19 [ [ -LRB- cord-344480-6tcush4w 50 20 30 30 CD cord-344480-6tcush4w 50 21 ] ] -RRB- cord-344480-6tcush4w 50 22 , , , cord-344480-6tcush4w 50 23 by by IN cord-344480-6tcush4w 50 24 using use VBG cord-344480-6tcush4w 50 25 smart smart JJ cord-344480-6tcush4w 50 26 but but CC cord-344480-6tcush4w 50 27 firm firm JJ cord-344480-6tcush4w 50 28 public public JJ cord-344480-6tcush4w 50 29 health health NN cord-344480-6tcush4w 50 30 measures measure NNS cord-344480-6tcush4w 50 31 preventing prevent VBG cord-344480-6tcush4w 50 32 spreadout spreadout NNS cord-344480-6tcush4w 50 33 of of IN cord-344480-6tcush4w 50 34 the the DT cord-344480-6tcush4w 50 35 virus virus NN cord-344480-6tcush4w 50 36 and and CC cord-344480-6tcush4w 50 37 more more RBR cord-344480-6tcush4w 50 38 specific specific JJ cord-344480-6tcush4w 50 39 combinatorial combinatorial JJ cord-344480-6tcush4w 50 40 therapeutic therapeutic JJ cord-344480-6tcush4w 50 41 strategies strategy NNS cord-344480-6tcush4w 50 42 , , , cord-344480-6tcush4w 50 43 such such JJ cord-344480-6tcush4w 50 44 as as IN cord-344480-6tcush4w 50 45 the the DT cord-344480-6tcush4w 50 46 anti anti JJ cord-344480-6tcush4w 50 47 - - JJ cord-344480-6tcush4w 50 48 viral viral JJ cord-344480-6tcush4w 50 49 convalescent convalescent JJ cord-344480-6tcush4w 50 50 plasma plasma NN cord-344480-6tcush4w 50 51 and and CC cord-344480-6tcush4w 50 52 drugs drug NNS cord-344480-6tcush4w 50 53 against against IN cord-344480-6tcush4w 50 54 cytokine cytokine NN cord-344480-6tcush4w 50 55 storm storm NN cord-344480-6tcush4w 50 56 for for IN cord-344480-6tcush4w 50 57 severe severe JJ cord-344480-6tcush4w 50 58 cases case NNS cord-344480-6tcush4w 50 59 , , , cord-344480-6tcush4w 50 60 as as RB cord-344480-6tcush4w 50 61 well well RB cord-344480-6tcush4w 50 62 as as IN cord-344480-6tcush4w 50 63 effective effective JJ cord-344480-6tcush4w 50 64 TCM TCM NNP cord-344480-6tcush4w 50 65 drugs drug NNS cord-344480-6tcush4w 50 66 and and CC cord-344480-6tcush4w 50 67 technologies technology NNS cord-344480-6tcush4w 50 68 , , , cord-344480-6tcush4w 50 69 we -PRON- PRP cord-344480-6tcush4w 50 70 believe believe VBP cord-344480-6tcush4w 50 71 that that IN cord-344480-6tcush4w 50 72 the the DT cord-344480-6tcush4w 50 73 mankind mankind NN cord-344480-6tcush4w 50 74 will will MD cord-344480-6tcush4w 50 75 win win VB cord-344480-6tcush4w 50 76 this this DT cord-344480-6tcush4w 50 77 battle battle NN cord-344480-6tcush4w 50 78 , , , cord-344480-6tcush4w 50 79 and and CC cord-344480-6tcush4w 50 80 Wuhan Wuhan NNP cord-344480-6tcush4w 50 81 will will MD cord-344480-6tcush4w 50 82 be be VB cord-344480-6tcush4w 50 83 back back RB cord-344480-6tcush4w 50 84 to to IN cord-344480-6tcush4w 50 85 the the DT cord-344480-6tcush4w 50 86 Spring spring NN cord-344480-6tcush4w 50 87 . . . cord-344480-6tcush4w 51 1 Guangbiao Guangbiao NNP cord-344480-6tcush4w 51 2 Zhou Zhou NNP cord-344480-6tcush4w 51 3 , , , cord-344480-6tcush4w 51 4 Saijuan Saijuan NNP cord-344480-6tcush4w 51 5 Chen Chen NNP cord-344480-6tcush4w 51 6 , , , cord-344480-6tcush4w 51 7 and and CC cord-344480-6tcush4w 51 8 Zhu Zhu NNP cord-344480-6tcush4w 51 9 Chen Chen NNP cord-344480-6tcush4w 51 10 declare declare VBP cord-344480-6tcush4w 51 11 no no DT cord-344480-6tcush4w 51 12 conflict conflict NN cord-344480-6tcush4w 51 13 of of IN cord-344480-6tcush4w 51 14 interests interest NNS cord-344480-6tcush4w 51 15 . . . cord-344480-6tcush4w 52 1 This this DT cord-344480-6tcush4w 52 2 manuscript manuscript NN cord-344480-6tcush4w 52 3 does do VBZ cord-344480-6tcush4w 52 4 not not RB cord-344480-6tcush4w 52 5 involve involve VB cord-344480-6tcush4w 52 6 a a DT cord-344480-6tcush4w 52 7 research research NN cord-344480-6tcush4w 52 8 protocol protocol NN cord-344480-6tcush4w 52 9 requiring require VBG cord-344480-6tcush4w 52 10 approval approval NN cord-344480-6tcush4w 52 11 by by IN cord-344480-6tcush4w 52 12 the the DT cord-344480-6tcush4w 52 13 relevant relevant JJ cord-344480-6tcush4w 52 14 institutional institutional JJ cord-344480-6tcush4w 52 15 review review NN cord-344480-6tcush4w 52 16 board board NNP cord-344480-6tcush4w 52 17 or or CC cord-344480-6tcush4w 52 18 ethics ethics NNP cord-344480-6tcush4w 52 19 committee committee NNP cord-344480-6tcush4w 52 20 . . . cord-344480-6tcush4w 53 1 China China NNP cord-344480-6tcush4w 53 2 Novel Novel NNP cord-344480-6tcush4w 53 3 Coronavirus Coronavirus NNP cord-344480-6tcush4w 53 4 Investigating Investigating NNP cord-344480-6tcush4w 53 5 and and CC cord-344480-6tcush4w 53 6 Research Research NNP cord-344480-6tcush4w 53 7 Team Team NNP cord-344480-6tcush4w 53 8 . . . cord-344480-6tcush4w 54 1 A a DT cord-344480-6tcush4w 54 2 novel novel JJ cord-344480-6tcush4w 54 3 coronavirus coronavirus NN cord-344480-6tcush4w 54 4 from from IN cord-344480-6tcush4w 54 5 patients patient NNS cord-344480-6tcush4w 54 6 with with IN cord-344480-6tcush4w 54 7 pneumonia pneumonia NN cord-344480-6tcush4w 54 8 in in IN cord-344480-6tcush4w 54 9 China China NNP cord-344480-6tcush4w 54 10 Severe severe JJ cord-344480-6tcush4w 54 11 acute acute JJ cord-344480-6tcush4w 54 12 respiratory respiratory JJ cord-344480-6tcush4w 54 13 syndromerelated syndromerelate VBN cord-344480-6tcush4w 54 14 coronavirus coronavirus NN cord-344480-6tcush4w 54 15 : : : cord-344480-6tcush4w 54 16 the the DT cord-344480-6tcush4w 54 17 species specie NNS cord-344480-6tcush4w 54 18 and and CC cord-344480-6tcush4w 54 19 its -PRON- PRP$ cord-344480-6tcush4w 54 20 viruses virus NNS cord-344480-6tcush4w 54 21 -a -a : cord-344480-6tcush4w 54 22 statement statement NN cord-344480-6tcush4w 54 23 of of IN cord-344480-6tcush4w 54 24 the the DT cord-344480-6tcush4w 54 25 Coronavirus Coronavirus NNP cord-344480-6tcush4w 54 26 Study Study NNP cord-344480-6tcush4w 54 27 Group Group NNP cord-344480-6tcush4w 54 28 A a DT cord-344480-6tcush4w 54 29 distinct distinct JJ cord-344480-6tcush4w 54 30 name name NN cord-344480-6tcush4w 54 31 is be VBZ cord-344480-6tcush4w 54 32 needed need VBN cord-344480-6tcush4w 54 33 for for IN cord-344480-6tcush4w 54 34 the the DT cord-344480-6tcush4w 54 35 new new JJ cord-344480-6tcush4w 54 36 coronavirus coronavirus NN cord-344480-6tcush4w 54 37 Epidemiological epidemiological JJ cord-344480-6tcush4w 54 38 research research NN cord-344480-6tcush4w 54 39 priorities priority NNS cord-344480-6tcush4w 54 40 for for IN cord-344480-6tcush4w 54 41 public public JJ cord-344480-6tcush4w 54 42 health health NN cord-344480-6tcush4w 54 43 control control NN cord-344480-6tcush4w 54 44 of of IN cord-344480-6tcush4w 54 45 the the DT cord-344480-6tcush4w 54 46 ongoing ongoing JJ cord-344480-6tcush4w 54 47 global global JJ cord-344480-6tcush4w 54 48 novel novel JJ cord-344480-6tcush4w 54 49 coronavirus coronavirus NN cord-344480-6tcush4w 54 50 ( ( -LRB- cord-344480-6tcush4w 54 51 2019-nCoV 2019-ncov CD cord-344480-6tcush4w 54 52 ) ) -RRB- cord-344480-6tcush4w 54 53 outbreak outbreak NN cord-344480-6tcush4w 55 1 A a DT cord-344480-6tcush4w 55 2 novel novel JJ cord-344480-6tcush4w 55 3 coronavirus coronavirus NN cord-344480-6tcush4w 55 4 outbreak outbreak NN cord-344480-6tcush4w 55 5 of of IN cord-344480-6tcush4w 55 6 global global JJ cord-344480-6tcush4w 55 7 health health NN cord-344480-6tcush4w 55 8 concern concern NN cord-344480-6tcush4w 55 9 China China NNP cord-344480-6tcush4w 55 10 's 's POS cord-344480-6tcush4w 55 11 local local JJ cord-344480-6tcush4w 55 12 governments government NNS cord-344480-6tcush4w 55 13 are be VBP cord-344480-6tcush4w 55 14 combating combat VBG cord-344480-6tcush4w 55 15 COVID-19 covid-19 CD cord-344480-6tcush4w 55 16 with with IN cord-344480-6tcush4w 55 17 unprecedented unprecedented JJ cord-344480-6tcush4w 55 18 responses response NNS cord-344480-6tcush4w 55 19 -from -from . cord-344480-6tcush4w 56 1 a a DT cord-344480-6tcush4w 56 2 Wenzhou Wenzhou NNP cord-344480-6tcush4w 56 3 governance governance NN cord-344480-6tcush4w 56 4 perspective perspective NN cord-344480-6tcush4w 56 5 Novel Novel NNP cord-344480-6tcush4w 56 6 Coronavirus Coronavirus NNP cord-344480-6tcush4w 56 7 Pneumonia Pneumonia NNP cord-344480-6tcush4w 56 8 Emergency Emergency NNP cord-344480-6tcush4w 56 9 Response Response NNP cord-344480-6tcush4w 56 10 Epidemiology Epidemiology NNP cord-344480-6tcush4w 56 11 Team Team NNP cord-344480-6tcush4w 56 12 . . . cord-344480-6tcush4w 57 1 The the DT cord-344480-6tcush4w 57 2 epidemiological epidemiological JJ cord-344480-6tcush4w 57 3 characteristics characteristic NNS cord-344480-6tcush4w 57 4 of of IN cord-344480-6tcush4w 57 5 an an DT cord-344480-6tcush4w 57 6 outbreak outbreak NN cord-344480-6tcush4w 57 7 of of IN cord-344480-6tcush4w 57 8 2019 2019 CD cord-344480-6tcush4w 57 9 novel novel JJ cord-344480-6tcush4w 57 10 coronavirus coronavirus NN cord-344480-6tcush4w 57 11 diseases disease NNS cord-344480-6tcush4w 57 12 ( ( -LRB- cord-344480-6tcush4w 57 13 COVID-19 covid-19 VB cord-344480-6tcush4w 57 14 ) ) -RRB- cord-344480-6tcush4w 57 15 in in IN cord-344480-6tcush4w 57 16 China China NNP cord-344480-6tcush4w 57 17 Databased Databased NNP cord-344480-6tcush4w 57 18 analysis analysis NN cord-344480-6tcush4w 57 19 , , , cord-344480-6tcush4w 57 20 modelling modelling NN cord-344480-6tcush4w 57 21 and and CC cord-344480-6tcush4w 57 22 forecasting forecasting NN cord-344480-6tcush4w 57 23 of of IN cord-344480-6tcush4w 57 24 the the DT cord-344480-6tcush4w 57 25 novel novel JJ cord-344480-6tcush4w 57 26 coronavirus coronavirus NN cord-344480-6tcush4w 57 27 ( ( -LRB- cord-344480-6tcush4w 57 28 2019-nCoV 2019-ncov CD cord-344480-6tcush4w 57 29 ) ) -RRB- cord-344480-6tcush4w 57 30 outbreak outbreak NN cord-344480-6tcush4w 57 31 Early early JJ cord-344480-6tcush4w 57 32 transmission transmission NN cord-344480-6tcush4w 57 33 dynamics dynamic NNS cord-344480-6tcush4w 57 34 in in IN cord-344480-6tcush4w 57 35 Wuhan Wuhan NNP cord-344480-6tcush4w 57 36 , , , cord-344480-6tcush4w 57 37 China China NNP cord-344480-6tcush4w 57 38 , , , cord-344480-6tcush4w 57 39 of of IN cord-344480-6tcush4w 57 40 novel novel JJ cord-344480-6tcush4w 57 41 coronavirus coronavirus NN cord-344480-6tcush4w 57 42 - - HYPH cord-344480-6tcush4w 57 43 infected infect VBN cord-344480-6tcush4w 57 44 pneumonia pneumonia NN cord-344480-6tcush4w 57 45 Clinical clinical JJ cord-344480-6tcush4w 57 46 features feature NNS cord-344480-6tcush4w 57 47 of of IN cord-344480-6tcush4w 57 48 patients patient NNS cord-344480-6tcush4w 57 49 infected infect VBN cord-344480-6tcush4w 57 50 with with IN cord-344480-6tcush4w 57 51 2019 2019 CD cord-344480-6tcush4w 57 52 novel novel JJ cord-344480-6tcush4w 57 53 coronavirus coronavirus NN cord-344480-6tcush4w 57 54 in in IN cord-344480-6tcush4w 57 55 Wuhan Wuhan NNP cord-344480-6tcush4w 57 56 , , , cord-344480-6tcush4w 57 57 China China NNP cord-344480-6tcush4w 57 58 Epidemiological epidemiological JJ cord-344480-6tcush4w 57 59 and and CC cord-344480-6tcush4w 57 60 clinical clinical JJ cord-344480-6tcush4w 57 61 characteristics characteristic NNS cord-344480-6tcush4w 57 62 of of IN cord-344480-6tcush4w 57 63 99 99 CD cord-344480-6tcush4w 57 64 cases case NNS cord-344480-6tcush4w 57 65 of of IN cord-344480-6tcush4w 57 66 2019 2019 CD cord-344480-6tcush4w 57 67 novel novel JJ cord-344480-6tcush4w 57 68 coronavirus coronavirus NN cord-344480-6tcush4w 57 69 pneumonia pneumonia NN cord-344480-6tcush4w 57 70 in in IN cord-344480-6tcush4w 57 71 Wuhan Wuhan NNP cord-344480-6tcush4w 57 72 , , , cord-344480-6tcush4w 57 73 China China NNP cord-344480-6tcush4w 57 74 : : : cord-344480-6tcush4w 57 75 a a DT cord-344480-6tcush4w 57 76 descriptive descriptive JJ cord-344480-6tcush4w 57 77 study study NN cord-344480-6tcush4w 57 78 Pathological pathological JJ cord-344480-6tcush4w 57 79 findings finding NNS cord-344480-6tcush4w 57 80 of of IN cord-344480-6tcush4w 57 81 COVID-19 COVID-19 NNP cord-344480-6tcush4w 57 82 associated associate VBN cord-344480-6tcush4w 57 83 with with IN cord-344480-6tcush4w 57 84 acute acute JJ cord-344480-6tcush4w 57 85 respiratory respiratory JJ cord-344480-6tcush4w 57 86 distress distress NN cord-344480-6tcush4w 57 87 syndrome syndrome NN cord-344480-6tcush4w 57 88 Genomic genomic JJ cord-344480-6tcush4w 57 89 characterisation characterisation NN cord-344480-6tcush4w 57 90 and and CC cord-344480-6tcush4w 57 91 epidemiology epidemiology NN cord-344480-6tcush4w 57 92 of of IN cord-344480-6tcush4w 57 93 2019 2019 CD cord-344480-6tcush4w 57 94 novel novel JJ cord-344480-6tcush4w 57 95 coronavirus coronavirus NN cord-344480-6tcush4w 57 96 : : : cord-344480-6tcush4w 57 97 implications implication NNS cord-344480-6tcush4w 57 98 for for IN cord-344480-6tcush4w 57 99 virus virus NN cord-344480-6tcush4w 57 100 origins origin NNS cord-344480-6tcush4w 57 101 and and CC cord-344480-6tcush4w 57 102 receptor receptor NN cord-344480-6tcush4w 57 103 binding bind VBG cord-344480-6tcush4w 57 104 A a DT cord-344480-6tcush4w 57 105 pneumonia pneumonia NN cord-344480-6tcush4w 57 106 outbreak outbreak NN cord-344480-6tcush4w 57 107 associated associate VBN cord-344480-6tcush4w 57 108 with with IN cord-344480-6tcush4w 57 109 a a DT cord-344480-6tcush4w 57 110 new new JJ cord-344480-6tcush4w 57 111 coronavirus coronavirus NN cord-344480-6tcush4w 57 112 of of IN cord-344480-6tcush4w 57 113 probable probable JJ cord-344480-6tcush4w 57 114 bat bat NN cord-344480-6tcush4w 57 115 origin origin NN cord-344480-6tcush4w 57 116 Identification identification NN cord-344480-6tcush4w 57 117 of of IN cord-344480-6tcush4w 57 118 2019-nCoV 2019-ncov CD cord-344480-6tcush4w 57 119 related relate VBN cord-344480-6tcush4w 57 120 coronaviruses coronaviruse NNS cord-344480-6tcush4w 57 121 in in IN cord-344480-6tcush4w 57 122 Malayan malayan JJ cord-344480-6tcush4w 57 123 pangolins pangolin NNS cord-344480-6tcush4w 57 124 in in IN cord-344480-6tcush4w 57 125 southern southern JJ cord-344480-6tcush4w 57 126 China China NNP cord-344480-6tcush4w 57 127 SARS SARS NNP cord-344480-6tcush4w 57 128 - - HYPH cord-344480-6tcush4w 57 129 CoV-2 CoV-2 NNP cord-344480-6tcush4w 57 130 viral viral JJ cord-344480-6tcush4w 57 131 load load NN cord-344480-6tcush4w 57 132 in in IN cord-344480-6tcush4w 57 133 upper upper JJ cord-344480-6tcush4w 57 134 respiratory respiratory JJ cord-344480-6tcush4w 57 135 specimens specimen NNS cord-344480-6tcush4w 57 136 of of IN cord-344480-6tcush4w 57 137 infected infected JJ cord-344480-6tcush4w 57 138 patients patient NNS cord-344480-6tcush4w 57 139 Functional functional JJ cord-344480-6tcush4w 57 140 assessment assessment NN cord-344480-6tcush4w 57 141 of of IN cord-344480-6tcush4w 57 142 cell cell NN cord-344480-6tcush4w 57 143 entry entry NN cord-344480-6tcush4w 57 144 and and CC cord-344480-6tcush4w 57 145 receptor receptor NN cord-344480-6tcush4w 57 146 usage usage NN cord-344480-6tcush4w 57 147 for for IN cord-344480-6tcush4w 57 148 lineage lineage NN cord-344480-6tcush4w 57 149 B B NNP cord-344480-6tcush4w 57 150 β β NN cord-344480-6tcush4w 57 151 - - HYPH cord-344480-6tcush4w 57 152 coronaviruses coronaviruse NNS cord-344480-6tcush4w 57 153 , , , cord-344480-6tcush4w 57 154 including include VBG cord-344480-6tcush4w 57 155 2019-nCoV 2019-ncov CD cord-344480-6tcush4w 57 156 Cryo Cryo NNP cord-344480-6tcush4w 57 157 - - HYPH cord-344480-6tcush4w 57 158 EM EM NNP cord-344480-6tcush4w 57 159 structure structure NN cord-344480-6tcush4w 57 160 of of IN cord-344480-6tcush4w 57 161 the the DT cord-344480-6tcush4w 57 162 2019-nCoV 2019-ncov CD cord-344480-6tcush4w 57 163 spike spike NN cord-344480-6tcush4w 57 164 in in IN cord-344480-6tcush4w 57 165 the the DT cord-344480-6tcush4w 57 166 prefusion prefusion NN cord-344480-6tcush4w 57 167 conformation conformation NNP cord-344480-6tcush4w 57 168 Structure Structure NNP cord-344480-6tcush4w 57 169 of of IN cord-344480-6tcush4w 57 170 dimeric dimeric JJ cord-344480-6tcush4w 57 171 fulllength fulllength NN cord-344480-6tcush4w 57 172 human human JJ cord-344480-6tcush4w 57 173 ACE2 ACE2 NNP cord-344480-6tcush4w 57 174 in in IN cord-344480-6tcush4w 57 175 complex complex NN cord-344480-6tcush4w 57 176 with with IN cord-344480-6tcush4w 57 177 B b NN cord-344480-6tcush4w 57 178 0 0 CD cord-344480-6tcush4w 57 179 AT1 at1 NN cord-344480-6tcush4w 58 1 The the DT cord-344480-6tcush4w 58 2 single single JJ cord-344480-6tcush4w 58 3 - - HYPH cord-344480-6tcush4w 58 4 cell cell NN cord-344480-6tcush4w 58 5 RNA RNA NNP cord-344480-6tcush4w 58 6 - - HYPH cord-344480-6tcush4w 58 7 seq seq NNP cord-344480-6tcush4w 58 8 data data NN cord-344480-6tcush4w 58 9 analysis analysis NN cord-344480-6tcush4w 58 10 on on IN cord-344480-6tcush4w 58 11 the the DT cord-344480-6tcush4w 58 12 receptor receptor NN cord-344480-6tcush4w 58 13 ACE2 ACE2 NNP cord-344480-6tcush4w 58 14 expression expression NN cord-344480-6tcush4w 58 15 reveals reveal VBZ cord-344480-6tcush4w 58 16 the the DT cord-344480-6tcush4w 58 17 potential potential JJ cord-344480-6tcush4w 58 18 risk risk NN cord-344480-6tcush4w 58 19 of of IN cord-344480-6tcush4w 58 20 different different JJ cord-344480-6tcush4w 58 21 human human JJ cord-344480-6tcush4w 58 22 organs organ NNS cord-344480-6tcush4w 58 23 vulnerable vulnerable JJ cord-344480-6tcush4w 58 24 to to IN cord-344480-6tcush4w 58 25 Wuhan Wuhan NNP cord-344480-6tcush4w 58 26 2019-nCoV 2019-ncov CD cord-344480-6tcush4w 58 27 infection infection NN cord-344480-6tcush4w 58 28 Therapeutic therapeutic JJ cord-344480-6tcush4w 58 29 options option NNS cord-344480-6tcush4w 58 30 for for IN cord-344480-6tcush4w 58 31 the the DT cord-344480-6tcush4w 58 32 2019 2019 CD cord-344480-6tcush4w 58 33 novel novel NN cord-344480-6tcush4w 58 34 coronavirus coronavirus NN cord-344480-6tcush4w 58 35 ( ( -LRB- cord-344480-6tcush4w 58 36 2019-nCoV 2019-ncov CD cord-344480-6tcush4w 58 37 ) ) -RRB- cord-344480-6tcush4w 58 38 Remdesivir Remdesivir NNP cord-344480-6tcush4w 58 39 and and CC cord-344480-6tcush4w 58 40 chloroquine chloroquine NN cord-344480-6tcush4w 58 41 effectively effectively RB cord-344480-6tcush4w 58 42 inhibit inhibit VBP cord-344480-6tcush4w 58 43 the the DT cord-344480-6tcush4w 58 44 recently recently RB cord-344480-6tcush4w 58 45 emerged emerge VBN cord-344480-6tcush4w 58 46 novel novel JJ cord-344480-6tcush4w 58 47 coronavirus coronavirus NN cord-344480-6tcush4w 58 48 ( ( -LRB- cord-344480-6tcush4w 58 49 2019-nCoV 2019-ncov CD cord-344480-6tcush4w 58 50 ) ) -RRB- cord-344480-6tcush4w 58 51 in in IN cord-344480-6tcush4w 58 52 vitro vitro FW cord-344480-6tcush4w 58 53 Washington Washington NNP cord-344480-6tcush4w 58 54 State State NNP cord-344480-6tcush4w 58 55 2019-nCoV 2019-ncov CD cord-344480-6tcush4w 58 56 Case Case NNP cord-344480-6tcush4w 58 57 Investigation Investigation NNP cord-344480-6tcush4w 58 58 Team Team NNP cord-344480-6tcush4w 58 59 . . . cord-344480-6tcush4w 59 1 First first JJ cord-344480-6tcush4w 59 2 case case NN cord-344480-6tcush4w 59 3 of of IN cord-344480-6tcush4w 59 4 2019 2019 CD cord-344480-6tcush4w 59 5 novel novel JJ cord-344480-6tcush4w 59 6 coronavirus coronavirus NN cord-344480-6tcush4w 59 7 in in IN cord-344480-6tcush4w 59 8 the the DT cord-344480-6tcush4w 59 9 United United NNP cord-344480-6tcush4w 59 10 States States NNP cord-344480-6tcush4w 59 11 32 32 CD cord-344480-6tcush4w 59 12 recovered recover VBD cord-344480-6tcush4w 59 13 patients patient NNS cord-344480-6tcush4w 59 14 donate donate VBP cord-344480-6tcush4w 59 15 plasma plasma NN cord-344480-6tcush4w 59 16 to to IN cord-344480-6tcush4w 59 17 others other NNS cord-344480-6tcush4w 59 18 with with IN cord-344480-6tcush4w 59 19 coronavirus coronavirus NN cord-344480-6tcush4w 59 20 infection infection NN cord-344480-6tcush4w 59 21 Therapeutic therapeutic JJ cord-344480-6tcush4w 59 22 strategies strategy NNS cord-344480-6tcush4w 59 23 in in IN cord-344480-6tcush4w 59 24 an an DT cord-344480-6tcush4w 59 25 outbreak outbreak NN cord-344480-6tcush4w 59 26 scenario scenario NN cord-344480-6tcush4w 59 27 to to TO cord-344480-6tcush4w 59 28 treat treat VB cord-344480-6tcush4w 59 29 the the DT cord-344480-6tcush4w 59 30 novel novel JJ cord-344480-6tcush4w 59 31 coronavirus coronavirus NN cord-344480-6tcush4w 59 32 originating originate VBG cord-344480-6tcush4w 59 33 in in IN cord-344480-6tcush4w 59 34 Wuhan Wuhan NNP cord-344480-6tcush4w 59 35 , , , cord-344480-6tcush4w 59 36 China China NNP cord-344480-6tcush4w 59 37 . . . cord-344480-6tcush4w 60 1 ( ( -LRB- cord-344480-6tcush4w 60 2 version version NN cord-344480-6tcush4w 60 3 2 2 CD cord-344480-6tcush4w 60 4 ; ; : cord-344480-6tcush4w 60 5 peer peer NN cord-344480-6tcush4w 60 6 review review NN cord-344480-6tcush4w 60 7 : : : cord-344480-6tcush4w 60 8 2 2 CD cord-344480-6tcush4w 60 9 approved approve VBN cord-344480-6tcush4w 60 10 Scientists scientist NNS cord-344480-6tcush4w 60 11 target target VBP cord-344480-6tcush4w 60 12 major major JJ cord-344480-6tcush4w 60 13 cause cause NN cord-344480-6tcush4w 60 14 of of IN cord-344480-6tcush4w 60 15 critically critically RB cord-344480-6tcush4w 60 16 ill ill JJ cord-344480-6tcush4w 60 17 virus virus NN cord-344480-6tcush4w 60 18 deaths death NNS cord-344480-6tcush4w 60 19 . . . cord-344480-6tcush4w 61 1 China China NNP cord-344480-6tcush4w 61 2 Daily Daily NNP cord-344480-6tcush4w 61 3 Oseltamivir Oseltamivir NNP cord-344480-6tcush4w 61 4 compared compare VBN cord-344480-6tcush4w 61 5 with with IN cord-344480-6tcush4w 61 6 the the DT cord-344480-6tcush4w 61 7 Chinese chinese JJ cord-344480-6tcush4w 61 8 traditional traditional JJ cord-344480-6tcush4w 61 9 therapy therapy NN cord-344480-6tcush4w 61 10 maxingshigan maxingshigan NNP cord-344480-6tcush4w 61 11 - - HYPH cord-344480-6tcush4w 61 12 yinqiaosan yinqiaosan NNP cord-344480-6tcush4w 61 13 in in IN cord-344480-6tcush4w 61 14 the the DT cord-344480-6tcush4w 61 15 treatment treatment NN cord-344480-6tcush4w 61 16 of of IN cord-344480-6tcush4w 61 17 H1N1 H1N1 NNP cord-344480-6tcush4w 61 18 influenza influenza NN cord-344480-6tcush4w 61 19 : : : cord-344480-6tcush4w 61 20 a a DT cord-344480-6tcush4w 61 21 randomized randomized JJ cord-344480-6tcush4w 61 22 trial trial NN cord-344480-6tcush4w 61 23 Combination combination NN cord-344480-6tcush4w 61 24 of of IN cord-344480-6tcush4w 61 25 western western JJ cord-344480-6tcush4w 61 26 medicine medicine NN cord-344480-6tcush4w 61 27 and and CC cord-344480-6tcush4w 61 28 Chinese chinese JJ cord-344480-6tcush4w 61 29 patent patent NN cord-344480-6tcush4w 61 30 medicine medicine NN cord-344480-6tcush4w 61 31 in in IN cord-344480-6tcush4w 61 32 treating treat VBG cord-344480-6tcush4w 61 33 a a DT cord-344480-6tcush4w 61 34 family family NN cord-344480-6tcush4w 61 35 case case NN cord-344480-6tcush4w 61 36 of of IN cord-344480-6tcush4w 61 37 COVID-19 COVID-19 NNP cord-344480-6tcush4w 61 38 in in IN cord-344480-6tcush4w 61 39 Wuhan Wuhan NNP cord-344480-6tcush4w 61 40 Statement Statement NNP cord-344480-6tcush4w 61 41 in in IN cord-344480-6tcush4w 61 42 support support NN cord-344480-6tcush4w 61 43 of of IN cord-344480-6tcush4w 61 44 the the DT cord-344480-6tcush4w 61 45 scientists scientist NNS cord-344480-6tcush4w 61 46 , , , cord-344480-6tcush4w 61 47 public public JJ cord-344480-6tcush4w 61 48 health health NN cord-344480-6tcush4w 61 49 professionals professional NNS cord-344480-6tcush4w 61 50 , , , cord-344480-6tcush4w 61 51 and and CC cord-344480-6tcush4w 61 52 medical medical JJ cord-344480-6tcush4w 61 53 professionals professional NNS cord-344480-6tcush4w 61 54 of of IN cord-344480-6tcush4w 61 55 China China NNP cord-344480-6tcush4w 61 56 combatting combat VBG cord-344480-6tcush4w 61 57 COVID-19 COVID-19 NNP