id author title date pages extension mime words sentences flesch summary cache txt cord-336963-evjmz49u Chen, Dong Exposure to SARS-CoV-2 in a high transmission setting increases the risk of severe COVID-19 compared to exposure to a low transmission setting? 2020-06-05 .txt text/plain 470 38 61 title: Exposure to SARS-CoV-2 in a high transmission setting increases the risk of severe COVID-19 compared to exposure to a low transmission setting? 1 However, the higher mortality persisted in Wuhan despite the fact that after the initial epidemic peak same clinical management guidelines were applied throughout China, and case fatality rates remained higher even when more medical personnel was deployed to Wuhan. 6 The high mortality in Northern Italy was also initially attributed to the fact that hospitals were overwhelmed by the onstorm of cases. But maybe there is another factor inherent to high transmission settings that lead to a higher case fatality rate as observed in our study? In conclusion, our study highlights that SARS-CoV-2 infection in a hotspot or epicentre with high transmission intensity may adversely impact mortality rates compared to infection in a low transmission area. ./cache/cord-336963-evjmz49u.txt ./txt/cord-336963-evjmz49u.txt