id sid tid token lemma pos cord-333672-ef53l283 1 1 key key JJ cord-333672-ef53l283 1 2 : : : cord-333672-ef53l283 1 3 cord-333672-ef53l283 cord-333672-ef53l283 NNS cord-333672-ef53l283 1 4 authors author NNS cord-333672-ef53l283 1 5 : : : cord-333672-ef53l283 1 6 Potter Potter NNP cord-333672-ef53l283 1 7 , , , cord-333672-ef53l283 1 8 Gregory Gregory NNP cord-333672-ef53l283 1 9 D. D. NNP cord-333672-ef53l283 1 10 M. M. NNP cord-333672-ef53l283 1 11 ; ; : cord-333672-ef53l283 1 12 Wood Wood NNP cord-333672-ef53l283 1 13 , , , cord-333672-ef53l283 1 14 Thomas Thomas NNP cord-333672-ef53l283 1 15 R. R. NNP cord-333672-ef53l283 1 16 title title NN cord-333672-ef53l283 1 17 : : : cord-333672-ef53l283 1 18 The the DT cord-333672-ef53l283 1 19 Future Future NNP cord-333672-ef53l283 1 20 of of IN cord-333672-ef53l283 1 21 Shift Shift NNP cord-333672-ef53l283 1 22 Work Work NNP cord-333672-ef53l283 1 23 : : : cord-333672-ef53l283 2 1 Circadian circadian JJ cord-333672-ef53l283 2 2 Biology biology NN cord-333672-ef53l283 2 3 Meets meet VBZ cord-333672-ef53l283 2 4 Personalised Personalised NNP cord-333672-ef53l283 2 5 Medicine Medicine NNP cord-333672-ef53l283 2 6 and and CC cord-333672-ef53l283 2 7 Behavioural Behavioural NNP cord-333672-ef53l283 2 8 Science Science NNP cord-333672-ef53l283 2 9 date date NN cord-333672-ef53l283 2 10 : : : cord-333672-ef53l283 2 11 2020 2020 CD cord-333672-ef53l283 2 12 - - HYPH cord-333672-ef53l283 2 13 08 08 CD cord-333672-ef53l283 2 14 - - HYPH cord-333672-ef53l283 2 15 07 07 CD cord-333672-ef53l283 2 16 journal journal NN cord-333672-ef53l283 2 17 : : : cord-333672-ef53l283 3 1 Front front JJ cord-333672-ef53l283 3 2 Nutr Nutr NNP cord-333672-ef53l283 3 3 DOI doi NN cord-333672-ef53l283 3 4 : : : cord-333672-ef53l283 4 1 10.3389 10.3389 CD cord-333672-ef53l283 4 2 / / SYM cord-333672-ef53l283 4 3 fnut.2020.00116 fnut.2020.00116 VBP cord-333672-ef53l283 4 4 sha sha NNP cord-333672-ef53l283 4 5 : : : cord-333672-ef53l283 4 6 f587c22064d5c1f8f83fbb37360c5d050f880fea f587c22064d5c1f8f83fbb37360c5d050f880fea NNP cord-333672-ef53l283 4 7 doc_id doc_id CD cord-333672-ef53l283 4 8 : : : cord-333672-ef53l283 4 9 333672 333672 CD cord-333672-ef53l283 4 10 cord_uid cord_uid NNS cord-333672-ef53l283 4 11 : : : cord-333672-ef53l283 5 1 ef53l283 ef53l283 NNP cord-333672-ef53l283 6 1 Shift shift JJ cord-333672-ef53l283 6 2 work work NN cord-333672-ef53l283 6 3 is be VBZ cord-333672-ef53l283 6 4 commonplace commonplace JJ cord-333672-ef53l283 6 5 in in IN cord-333672-ef53l283 6 6 modern modern JJ cord-333672-ef53l283 6 7 societies society NNS cord-333672-ef53l283 6 8 , , , cord-333672-ef53l283 6 9 and and CC cord-333672-ef53l283 6 10 shift shift VB cord-333672-ef53l283 6 11 workers worker NNS cord-333672-ef53l283 6 12 are be VBP cord-333672-ef53l283 6 13 predisposed predisposed JJ cord-333672-ef53l283 6 14 to to IN cord-333672-ef53l283 6 15 the the DT cord-333672-ef53l283 6 16 development development NN cord-333672-ef53l283 6 17 of of IN cord-333672-ef53l283 6 18 numerous numerous JJ cord-333672-ef53l283 6 19 chronic chronic JJ cord-333672-ef53l283 6 20 diseases disease NNS cord-333672-ef53l283 6 21 . . . cord-333672-ef53l283 7 1 Disruptions disruption NNS cord-333672-ef53l283 7 2 to to IN cord-333672-ef53l283 7 3 the the DT cord-333672-ef53l283 7 4 circadian circadian NN cord-333672-ef53l283 7 5 systems system NNS cord-333672-ef53l283 7 6 of of IN cord-333672-ef53l283 7 7 shift shift NN cord-333672-ef53l283 7 8 workers worker NNS cord-333672-ef53l283 7 9 are be VBP cord-333672-ef53l283 7 10 considered consider VBN cord-333672-ef53l283 7 11 important important JJ cord-333672-ef53l283 7 12 contributors contributor NNS cord-333672-ef53l283 7 13 to to IN cord-333672-ef53l283 7 14 the the DT cord-333672-ef53l283 7 15 biological biological JJ cord-333672-ef53l283 7 16 dysfunction dysfunction NN cord-333672-ef53l283 7 17 these these DT cord-333672-ef53l283 7 18 people people NNS cord-333672-ef53l283 7 19 frequently frequently RB cord-333672-ef53l283 7 20 experience experience VBP cord-333672-ef53l283 7 21 . . . cord-333672-ef53l283 8 1 Because because IN cord-333672-ef53l283 8 2 of of IN cord-333672-ef53l283 8 3 this this DT cord-333672-ef53l283 8 4 , , , cord-333672-ef53l283 8 5 understanding understand VBG cord-333672-ef53l283 8 6 how how WRB cord-333672-ef53l283 8 7 to to TO cord-333672-ef53l283 8 8 alter alter VB cord-333672-ef53l283 8 9 shift shift NN cord-333672-ef53l283 8 10 work work NN cord-333672-ef53l283 8 11 and and CC cord-333672-ef53l283 8 12 zeitgeber zeitgeber NNP cord-333672-ef53l283 8 13 ( ( -LRB- cord-333672-ef53l283 8 14 time time NN cord-333672-ef53l283 8 15 cue cue NN cord-333672-ef53l283 8 16 ) ) -RRB- cord-333672-ef53l283 8 17 schedules schedule NNS cord-333672-ef53l283 8 18 to to TO cord-333672-ef53l283 8 19 enhance enhance VB cord-333672-ef53l283 8 20 circadian circadian NN cord-333672-ef53l283 8 21 system system NN cord-333672-ef53l283 8 22 function function NN cord-333672-ef53l283 8 23 is be VBZ cord-333672-ef53l283 8 24 likely likely JJ cord-333672-ef53l283 8 25 to to TO cord-333672-ef53l283 8 26 be be VB cord-333672-ef53l283 8 27 key key JJ cord-333672-ef53l283 8 28 to to IN cord-333672-ef53l283 8 29 improving improve VBG cord-333672-ef53l283 8 30 the the DT cord-333672-ef53l283 8 31 health health NN cord-333672-ef53l283 8 32 of of IN cord-333672-ef53l283 8 33 shift shift NN cord-333672-ef53l283 8 34 workers worker NNS cord-333672-ef53l283 8 35 . . . cord-333672-ef53l283 9 1 While while IN cord-333672-ef53l283 9 2 light light JJ cord-333672-ef53l283 9 3 exposure exposure NN cord-333672-ef53l283 9 4 is be VBZ cord-333672-ef53l283 9 5 the the DT cord-333672-ef53l283 9 6 most most RBS cord-333672-ef53l283 9 7 important important JJ cord-333672-ef53l283 9 8 zeitgeber zeitgeber NN cord-333672-ef53l283 9 9 for for IN cord-333672-ef53l283 9 10 the the DT cord-333672-ef53l283 9 11 central central JJ cord-333672-ef53l283 9 12 clock clock NN cord-333672-ef53l283 9 13 in in IN cord-333672-ef53l283 9 14 the the DT cord-333672-ef53l283 9 15 circadian circadian NN cord-333672-ef53l283 9 16 system system NN cord-333672-ef53l283 9 17 , , , cord-333672-ef53l283 9 18 diet diet NN cord-333672-ef53l283 9 19 and and CC cord-333672-ef53l283 9 20 exercise exercise NN cord-333672-ef53l283 9 21 are be VBP cord-333672-ef53l283 9 22 plausible plausible JJ cord-333672-ef53l283 9 23 zeitgebers zeitgeber NNS cord-333672-ef53l283 9 24 for for IN cord-333672-ef53l283 9 25 circadian circadian NN cord-333672-ef53l283 9 26 clocks clock NNS cord-333672-ef53l283 9 27 in in IN cord-333672-ef53l283 9 28 many many JJ cord-333672-ef53l283 9 29 tissues tissue NNS cord-333672-ef53l283 9 30 . . . cord-333672-ef53l283 10 1 We -PRON- PRP cord-333672-ef53l283 10 2 know know VBP cord-333672-ef53l283 10 3 little little JJ cord-333672-ef53l283 10 4 about about IN cord-333672-ef53l283 10 5 how how WRB cord-333672-ef53l283 10 6 different different JJ cord-333672-ef53l283 10 7 zeitgebers zeitgeber NNS cord-333672-ef53l283 10 8 interact interact VBP cord-333672-ef53l283 10 9 and and CC cord-333672-ef53l283 10 10 how how WRB cord-333672-ef53l283 10 11 to to TO cord-333672-ef53l283 10 12 tailor tailor VB cord-333672-ef53l283 10 13 zeitgeber zeitgeber NNP cord-333672-ef53l283 10 14 schedules schedule NNS cord-333672-ef53l283 10 15 to to IN cord-333672-ef53l283 10 16 the the DT cord-333672-ef53l283 10 17 needs need NNS cord-333672-ef53l283 10 18 of of IN cord-333672-ef53l283 10 19 individuals individual NNS cord-333672-ef53l283 10 20 ; ; : cord-333672-ef53l283 10 21 however however RB cord-333672-ef53l283 10 22 , , , cord-333672-ef53l283 10 23 in in IN cord-333672-ef53l283 10 24 this this DT cord-333672-ef53l283 10 25 review review NN cord-333672-ef53l283 10 26 we -PRON- PRP cord-333672-ef53l283 10 27 share share VBP cord-333672-ef53l283 10 28 some some DT cord-333672-ef53l283 10 29 guidelines guideline NNS cord-333672-ef53l283 10 30 to to TO cord-333672-ef53l283 10 31 help help VB cord-333672-ef53l283 10 32 shift shift VB cord-333672-ef53l283 10 33 workers worker NNS cord-333672-ef53l283 10 34 adapt adapt VB cord-333672-ef53l283 10 35 to to IN cord-333672-ef53l283 10 36 their -PRON- PRP$ cord-333672-ef53l283 10 37 work work NN cord-333672-ef53l283 10 38 schedules schedule NNS cord-333672-ef53l283 10 39 based base VBN cord-333672-ef53l283 10 40 on on IN cord-333672-ef53l283 10 41 our -PRON- PRP$ cord-333672-ef53l283 10 42 current current JJ cord-333672-ef53l283 10 43 understanding understanding NN cord-333672-ef53l283 10 44 of of IN cord-333672-ef53l283 10 45 circadian circadian NN cord-333672-ef53l283 10 46 biology biology NN cord-333672-ef53l283 10 47 . . . cord-333672-ef53l283 11 1 We -PRON- PRP cord-333672-ef53l283 11 2 focus focus VBP cord-333672-ef53l283 11 3 in in IN cord-333672-ef53l283 11 4 particular particular JJ cord-333672-ef53l283 11 5 on on IN cord-333672-ef53l283 11 6 the the DT cord-333672-ef53l283 11 7 importance importance NN cord-333672-ef53l283 11 8 of of IN cord-333672-ef53l283 11 9 diet diet NN cord-333672-ef53l283 11 10 timing timing NN cord-333672-ef53l283 11 11 and and CC cord-333672-ef53l283 11 12 composition composition NN cord-333672-ef53l283 11 13 . . . cord-333672-ef53l283 12 1 Going go VBG cord-333672-ef53l283 12 2 forward forward RB cord-333672-ef53l283 12 3 , , , cord-333672-ef53l283 12 4 developments development NNS cord-333672-ef53l283 12 5 in in IN cord-333672-ef53l283 12 6 phenotyping phenotyping NN cord-333672-ef53l283 12 7 and and CC cord-333672-ef53l283 12 8 “ " `` cord-333672-ef53l283 12 9 envirotyping envirotype VBG cord-333672-ef53l283 12 10 ” " '' cord-333672-ef53l283 12 11 methods method NNS cord-333672-ef53l283 12 12 may may MD cord-333672-ef53l283 12 13 be be VB cord-333672-ef53l283 12 14 important important JJ cord-333672-ef53l283 12 15 to to IN cord-333672-ef53l283 12 16 understanding understand VBG cord-333672-ef53l283 12 17 how how WRB cord-333672-ef53l283 12 18 to to TO cord-333672-ef53l283 12 19 optimise optimise VB cord-333672-ef53l283 12 20 shift shift NN cord-333672-ef53l283 12 21 work work NN cord-333672-ef53l283 12 22 . . . cord-333672-ef53l283 13 1 Non non JJ cord-333672-ef53l283 13 2 - - JJ cord-333672-ef53l283 13 3 invasive invasive JJ cord-333672-ef53l283 13 4 , , , cord-333672-ef53l283 13 5 multimodal multimodal NN cord-333672-ef53l283 13 6 , , , cord-333672-ef53l283 13 7 comprehensive comprehensive JJ cord-333672-ef53l283 13 8 phenotyping phenotyping NN cord-333672-ef53l283 13 9 using use VBG cord-333672-ef53l283 13 10 multiple multiple JJ cord-333672-ef53l283 13 11 sources source NNS cord-333672-ef53l283 13 12 of of IN cord-333672-ef53l283 13 13 time time NN cord-333672-ef53l283 13 14 - - HYPH cord-333672-ef53l283 13 15 stamped stamp VBN cord-333672-ef53l283 13 16 data datum NNS cord-333672-ef53l283 13 17 may may MD cord-333672-ef53l283 13 18 yield yield VB cord-333672-ef53l283 13 19 insights insight NNS cord-333672-ef53l283 13 20 that that WDT cord-333672-ef53l283 13 21 are be VBP cord-333672-ef53l283 13 22 critical critical JJ cord-333672-ef53l283 13 23 to to IN cord-333672-ef53l283 13 24 the the DT cord-333672-ef53l283 13 25 care care NN cord-333672-ef53l283 13 26 of of IN cord-333672-ef53l283 13 27 shift shift NN cord-333672-ef53l283 13 28 workers worker NNS cord-333672-ef53l283 13 29 . . . cord-333672-ef53l283 14 1 Finally finally RB cord-333672-ef53l283 14 2 , , , cord-333672-ef53l283 14 3 the the DT cord-333672-ef53l283 14 4 impact impact NN cord-333672-ef53l283 14 5 of of IN cord-333672-ef53l283 14 6 these these DT cord-333672-ef53l283 14 7 advances advance NNS cord-333672-ef53l283 14 8 will will MD cord-333672-ef53l283 14 9 be be VB cord-333672-ef53l283 14 10 reduced reduce VBN cord-333672-ef53l283 14 11 without without IN cord-333672-ef53l283 14 12 modifications modification NNS cord-333672-ef53l283 14 13 to to TO cord-333672-ef53l283 14 14 work work VB cord-333672-ef53l283 14 15 environments environment NNS cord-333672-ef53l283 14 16 to to TO cord-333672-ef53l283 14 17 make make VB cord-333672-ef53l283 14 18 it -PRON- PRP cord-333672-ef53l283 14 19 easier easy JJR cord-333672-ef53l283 14 20 for for IN cord-333672-ef53l283 14 21 shift shift NN cord-333672-ef53l283 14 22 workers worker NNS cord-333672-ef53l283 14 23 to to TO cord-333672-ef53l283 14 24 engage engage VB cord-333672-ef53l283 14 25 in in IN cord-333672-ef53l283 14 26 behaviours behaviour NNS cord-333672-ef53l283 14 27 conducive conducive JJ cord-333672-ef53l283 14 28 to to IN cord-333672-ef53l283 14 29 their -PRON- PRP$ cord-333672-ef53l283 14 30 health health NN cord-333672-ef53l283 14 31 . . . cord-333672-ef53l283 15 1 Integrating integrate VBG cord-333672-ef53l283 15 2 findings finding NNS cord-333672-ef53l283 15 3 from from IN cord-333672-ef53l283 15 4 behavioural behavioural JJ cord-333672-ef53l283 15 5 science science NN cord-333672-ef53l283 15 6 and and CC cord-333672-ef53l283 15 7 ergonomics ergonomic NNS cord-333672-ef53l283 15 8 may may MD cord-333672-ef53l283 15 9 help help VB cord-333672-ef53l283 15 10 shift shift VB cord-333672-ef53l283 15 11 workers worker NNS cord-333672-ef53l283 15 12 make make VB cord-333672-ef53l283 15 13 healthier healthy JJR cord-333672-ef53l283 15 14 choices choice NNS cord-333672-ef53l283 15 15 , , , cord-333672-ef53l283 15 16 thereby thereby RB cord-333672-ef53l283 15 17 amplifying amplify VBG cord-333672-ef53l283 15 18 the the DT cord-333672-ef53l283 15 19 beneficial beneficial JJ cord-333672-ef53l283 15 20 effects effect NNS cord-333672-ef53l283 15 21 of of IN cord-333672-ef53l283 15 22 improved improved JJ cord-333672-ef53l283 15 23 lifestyle lifestyle NN cord-333672-ef53l283 15 24 prescriptions prescription NNS cord-333672-ef53l283 15 25 for for IN cord-333672-ef53l283 15 26 these these DT cord-333672-ef53l283 15 27 people people NNS cord-333672-ef53l283 15 28 . . . cord-333672-ef53l283 16 1 Simplistically simplistically RB cord-333672-ef53l283 16 2 , , , cord-333672-ef53l283 16 3 our -PRON- PRP$ cord-333672-ef53l283 16 4 species specie NNS cord-333672-ef53l283 16 5 once once RB cord-333672-ef53l283 16 6 lived live VBD cord-333672-ef53l283 16 7 by by IN cord-333672-ef53l283 16 8 two two CD cord-333672-ef53l283 16 9 " " `` cord-333672-ef53l283 16 10 clocks clock NNS cord-333672-ef53l283 16 11 . . . cord-333672-ef53l283 17 1 " " `` cord-333672-ef53l283 17 2 One one CD cord-333672-ef53l283 17 3 of of IN cord-333672-ef53l283 17 4 these these DT cord-333672-ef53l283 17 5 clocks clock NNS cord-333672-ef53l283 17 6 is be VBZ cord-333672-ef53l283 17 7 the the DT cord-333672-ef53l283 17 8 environmental environmental JJ cord-333672-ef53l283 17 9 clock clock NN cord-333672-ef53l283 17 10 , , , cord-333672-ef53l283 17 11 which which WDT cord-333672-ef53l283 17 12 generates generate VBZ cord-333672-ef53l283 17 13 roughly roughly RB cord-333672-ef53l283 17 14 24-h 24-h JJ cord-333672-ef53l283 17 15 changes change NNS cord-333672-ef53l283 17 16 in in IN cord-333672-ef53l283 17 17 the the DT cord-333672-ef53l283 17 18 light light JJ cord-333672-ef53l283 17 19 / / SYM cord-333672-ef53l283 17 20 dark dark NN cord-333672-ef53l283 17 21 ( ( -LRB- cord-333672-ef53l283 17 22 LD LD NNP cord-333672-ef53l283 17 23 ) ) -RRB- cord-333672-ef53l283 17 24 cycle cycle NN cord-333672-ef53l283 17 25 . . . cord-333672-ef53l283 18 1 The the DT cord-333672-ef53l283 18 2 other other JJ cord-333672-ef53l283 18 3 clock clock NN cord-333672-ef53l283 18 4 is be VBZ cord-333672-ef53l283 18 5 the the DT cord-333672-ef53l283 18 6 endogenous endogenous JJ cord-333672-ef53l283 18 7 biological biological JJ cord-333672-ef53l283 18 8 clock clock NN cord-333672-ef53l283 18 9 , , , cord-333672-ef53l283 18 10 which which WDT cord-333672-ef53l283 18 11 among among IN cord-333672-ef53l283 18 12 other other JJ cord-333672-ef53l283 18 13 rhythms rhythm NNS cord-333672-ef53l283 18 14 generates generate VBZ cord-333672-ef53l283 18 15 roughly roughly RB cord-333672-ef53l283 18 16 24-h 24-h JJ cord-333672-ef53l283 18 17 ( ( -LRB- cord-333672-ef53l283 18 18 circadian circadian NN cord-333672-ef53l283 18 19 ) ) -RRB- cord-333672-ef53l283 18 20 rhythms rhythm NNS cord-333672-ef53l283 18 21 in in IN cord-333672-ef53l283 18 22 biological biological JJ cord-333672-ef53l283 18 23 outputs output NNS cord-333672-ef53l283 18 24 such such JJ cord-333672-ef53l283 18 25 as as IN cord-333672-ef53l283 18 26 the the DT cord-333672-ef53l283 18 27 sleep sleep NN cord-333672-ef53l283 18 28 / / SYM cord-333672-ef53l283 18 29 wake wake VBP cord-333672-ef53l283 18 30 cycle cycle NN cord-333672-ef53l283 18 31 . . . cord-333672-ef53l283 19 1 Prior prior RB cord-333672-ef53l283 19 2 to to IN cord-333672-ef53l283 19 3 the the DT cord-333672-ef53l283 19 4 introduction introduction NN cord-333672-ef53l283 19 5 of of IN cord-333672-ef53l283 19 6 artificial artificial JJ cord-333672-ef53l283 19 7 light light NN cord-333672-ef53l283 19 8 at at IN cord-333672-ef53l283 19 9 night night NN cord-333672-ef53l283 19 10 , , , cord-333672-ef53l283 19 11 these these DT cord-333672-ef53l283 19 12 two two CD cord-333672-ef53l283 19 13 clocks clock NNS cord-333672-ef53l283 19 14 were be VBD cord-333672-ef53l283 19 15 probably probably RB cord-333672-ef53l283 19 16 tightly tightly RB cord-333672-ef53l283 19 17 synchronised synchronised JJ cord-333672-ef53l283 19 18 ( ( -LRB- cord-333672-ef53l283 19 19 1 1 CD cord-333672-ef53l283 19 20 , , , cord-333672-ef53l283 19 21 2 2 CD cord-333672-ef53l283 19 22 ) ) -RRB- cord-333672-ef53l283 19 23 . . . cord-333672-ef53l283 20 1 Following follow VBG cord-333672-ef53l283 20 2 industrialisation industrialisation NN cord-333672-ef53l283 20 3 , , , cord-333672-ef53l283 20 4 however however RB cord-333672-ef53l283 20 5 , , , cord-333672-ef53l283 20 6 people people NNS cord-333672-ef53l283 20 7 can can MD cord-333672-ef53l283 20 8 more more RBR cord-333672-ef53l283 20 9 easily easily RB cord-333672-ef53l283 20 10 work work VB cord-333672-ef53l283 20 11 outside outside IN cord-333672-ef53l283 20 12 of of IN cord-333672-ef53l283 20 13 conventional conventional JJ cord-333672-ef53l283 20 14 daytime daytime JJ cord-333672-ef53l283 20 15 hours hour NNS cord-333672-ef53l283 20 16 , , , cord-333672-ef53l283 20 17 and and CC cord-333672-ef53l283 20 18 15 15 CD cord-333672-ef53l283 20 19 - - SYM cord-333672-ef53l283 20 20 20 20 CD cord-333672-ef53l283 20 21 % % NN cord-333672-ef53l283 20 22 of of IN cord-333672-ef53l283 20 23 the the DT cord-333672-ef53l283 20 24 working work VBG cord-333672-ef53l283 20 25 population population NN cord-333672-ef53l283 20 26 now now RB cord-333672-ef53l283 20 27 work work VBP cord-333672-ef53l283 20 28 shifts shift NNS cord-333672-ef53l283 20 29 ( ( -LRB- cord-333672-ef53l283 20 30 3 3 CD cord-333672-ef53l283 20 31 ) ) -RRB- cord-333672-ef53l283 20 32 . . . cord-333672-ef53l283 21 1 The the DT cord-333672-ef53l283 21 2 burden burden NN cord-333672-ef53l283 21 3 of of IN cord-333672-ef53l283 21 4 shift shift NN cord-333672-ef53l283 21 5 work work NN cord-333672-ef53l283 21 6 is be VBZ cord-333672-ef53l283 21 7 striking strike VBG cord-333672-ef53l283 21 8 : : : cord-333672-ef53l283 21 9 Shift shift JJ cord-333672-ef53l283 21 10 workers worker NNS cord-333672-ef53l283 21 11 are be VBP cord-333672-ef53l283 21 12 not not RB cord-333672-ef53l283 21 13 only only RB cord-333672-ef53l283 21 14 at at IN cord-333672-ef53l283 21 15 increased increase VBN cord-333672-ef53l283 21 16 risk risk NN cord-333672-ef53l283 21 17 of of IN cord-333672-ef53l283 21 18 accidents accident NNS cord-333672-ef53l283 21 19 ( ( -LRB- cord-333672-ef53l283 21 20 4 4 CD cord-333672-ef53l283 21 21 ) ) -RRB- cord-333672-ef53l283 21 22 , , , cord-333672-ef53l283 21 23 they -PRON- PRP cord-333672-ef53l283 21 24 are be VBP cord-333672-ef53l283 21 25 also also RB cord-333672-ef53l283 21 26 disposed dispose VBN cord-333672-ef53l283 21 27 to to IN cord-333672-ef53l283 21 28 developing develop VBG cord-333672-ef53l283 21 29 numerous numerous JJ cord-333672-ef53l283 21 30 diseases disease NNS cord-333672-ef53l283 21 31 , , , cord-333672-ef53l283 21 32 including include VBG cord-333672-ef53l283 21 33 certain certain JJ cord-333672-ef53l283 21 34 cancers cancer NNS cord-333672-ef53l283 21 35 , , , cord-333672-ef53l283 21 36 coronary coronary JJ cord-333672-ef53l283 21 37 heart heart NN cord-333672-ef53l283 21 38 disease disease NN cord-333672-ef53l283 21 39 , , , cord-333672-ef53l283 21 40 stroke stroke NN cord-333672-ef53l283 21 41 , , , cord-333672-ef53l283 21 42 and and CC cord-333672-ef53l283 21 43 type type NN cord-333672-ef53l283 21 44 - - HYPH cord-333672-ef53l283 21 45 two two CD cord-333672-ef53l283 21 46 diabetes diabete NNS cord-333672-ef53l283 21 47 ( ( -LRB- cord-333672-ef53l283 21 48 5 5 CD cord-333672-ef53l283 21 49 ) ) -RRB- cord-333672-ef53l283 21 50 . . . cord-333672-ef53l283 22 1 Few few JJ cord-333672-ef53l283 22 2 studies study NNS cord-333672-ef53l283 22 3 have have VBP cord-333672-ef53l283 22 4 explored explore VBN cord-333672-ef53l283 22 5 whether whether IN cord-333672-ef53l283 22 6 shift shift NN cord-333672-ef53l283 22 7 work work NN cord-333672-ef53l283 22 8 makes make VBZ cord-333672-ef53l283 22 9 individuals individual NNS cord-333672-ef53l283 22 10 prone prone JJ cord-333672-ef53l283 22 11 to to IN cord-333672-ef53l283 22 12 neurodegenerative neurodegenerative JJ cord-333672-ef53l283 22 13 diseases disease NNS cord-333672-ef53l283 22 14 ( ( -LRB- cord-333672-ef53l283 22 15 6 6 CD cord-333672-ef53l283 22 16 , , , cord-333672-ef53l283 22 17 7 7 CD cord-333672-ef53l283 22 18 ) ) -RRB- cord-333672-ef53l283 22 19 , , , cord-333672-ef53l283 22 20 but but CC cord-333672-ef53l283 22 21 shift shift NN cord-333672-ef53l283 22 22 work work NN cord-333672-ef53l283 22 23 frequently frequently RB cord-333672-ef53l283 22 24 disrupts disrupt VBZ cord-333672-ef53l283 22 25 biological biological JJ cord-333672-ef53l283 22 26 rhythms rhythm NNS cord-333672-ef53l283 22 27 and and CC cord-333672-ef53l283 22 28 sleep sleep NN cord-333672-ef53l283 22 29 , , , cord-333672-ef53l283 22 30 and and CC cord-333672-ef53l283 22 31 such such JJ cord-333672-ef53l283 22 32 disturbances disturbance NNS cord-333672-ef53l283 22 33 propagate propagate VBP cord-333672-ef53l283 22 34 a a DT cord-333672-ef53l283 22 35 slew slew NN cord-333672-ef53l283 22 36 of of IN cord-333672-ef53l283 22 37 pathobiological pathobiological JJ cord-333672-ef53l283 22 38 changes change NNS cord-333672-ef53l283 22 39 that that WDT cord-333672-ef53l283 22 40 contribute contribute VBP cord-333672-ef53l283 22 41 to to IN cord-333672-ef53l283 22 42 neurodegeneration neurodegeneration NN cord-333672-ef53l283 22 43 ( ( -LRB- cord-333672-ef53l283 22 44 8) 8) NN cord-333672-ef53l283 22 45 . . . cord-333672-ef53l283 23 1 While while IN cord-333672-ef53l283 23 2 at at IN cord-333672-ef53l283 23 3 the the DT cord-333672-ef53l283 23 4 time time NN cord-333672-ef53l283 23 5 of of IN cord-333672-ef53l283 23 6 writing write VBG cord-333672-ef53l283 23 7 little little JJ cord-333672-ef53l283 23 8 is be VBZ cord-333672-ef53l283 23 9 known know VBN cord-333672-ef53l283 23 10 about about IN cord-333672-ef53l283 23 11 the the DT cord-333672-ef53l283 23 12 effects effect NNS cord-333672-ef53l283 23 13 of of IN cord-333672-ef53l283 23 14 the the DT cord-333672-ef53l283 23 15 2019 2019 CD cord-333672-ef53l283 23 16 novel novel JJ cord-333672-ef53l283 23 17 coronavirus coronavirus NN cord-333672-ef53l283 23 18 disease disease NN cord-333672-ef53l283 23 19 ( ( -LRB- cord-333672-ef53l283 23 20 COVID-19 covid-19 VB cord-333672-ef53l283 23 21 ) ) -RRB- cord-333672-ef53l283 23 22 pandemic pandemic NN cord-333672-ef53l283 23 23 on on IN cord-333672-ef53l283 23 24 the the DT cord-333672-ef53l283 23 25 lives life NNS cord-333672-ef53l283 23 26 of of IN cord-333672-ef53l283 23 27 many many JJ cord-333672-ef53l283 23 28 shift shift NN cord-333672-ef53l283 23 29 workers worker NNS cord-333672-ef53l283 23 30 , , , cord-333672-ef53l283 23 31 we -PRON- PRP cord-333672-ef53l283 23 32 would would MD cord-333672-ef53l283 23 33 be be VB cord-333672-ef53l283 23 34 remiss remiss JJ cord-333672-ef53l283 23 35 not not RB cord-333672-ef53l283 23 36 to to TO cord-333672-ef53l283 23 37 mention mention VB cord-333672-ef53l283 23 38 that that IN cord-333672-ef53l283 23 39 many many JJ cord-333672-ef53l283 23 40 healthcare healthcare NN cord-333672-ef53l283 23 41 professionals professional NNS cord-333672-ef53l283 23 42 at at IN cord-333672-ef53l283 23 43 the the DT cord-333672-ef53l283 23 44 frontlines frontline NNS cord-333672-ef53l283 23 45 of of IN cord-333672-ef53l283 23 46 the the DT cord-333672-ef53l283 23 47 outbreak outbreak NN cord-333672-ef53l283 23 48 are be VBP cord-333672-ef53l283 23 49 currently currently RB cord-333672-ef53l283 23 50 working work VBG cord-333672-ef53l283 23 51 long long JJ cord-333672-ef53l283 23 52 shifts shift NNS cord-333672-ef53l283 23 53 in in IN cord-333672-ef53l283 23 54 conditions condition NNS cord-333672-ef53l283 23 55 that that WDT cord-333672-ef53l283 23 56 dispose dispose VBP cord-333672-ef53l283 23 57 them -PRON- PRP cord-333672-ef53l283 23 58 to to IN cord-333672-ef53l283 23 59 developing develop VBG cord-333672-ef53l283 23 60 COVID-19 COVID-19 NNP cord-333672-ef53l283 23 61 ( ( -LRB- cord-333672-ef53l283 23 62 9 9 CD cord-333672-ef53l283 23 63 ) ) -RRB- cord-333672-ef53l283 23 64 . . . cord-333672-ef53l283 24 1 Many many JJ cord-333672-ef53l283 24 2 of of IN cord-333672-ef53l283 24 3 the the DT cord-333672-ef53l283 24 4 chronic chronic JJ cord-333672-ef53l283 24 5 conditions condition NNS cord-333672-ef53l283 24 6 associated associate VBN cord-333672-ef53l283 24 7 with with IN cord-333672-ef53l283 24 8 shift shift NN cord-333672-ef53l283 24 9 work work NN cord-333672-ef53l283 24 10 are be VBP cord-333672-ef53l283 24 11 also also RB cord-333672-ef53l283 24 12 associated associate VBN cord-333672-ef53l283 24 13 with with IN cord-333672-ef53l283 24 14 greater great JJR cord-333672-ef53l283 24 15 risk risk NN cord-333672-ef53l283 24 16 of of IN cord-333672-ef53l283 24 17 poor poor JJ cord-333672-ef53l283 24 18 outcomes outcome NNS cord-333672-ef53l283 24 19 in in IN cord-333672-ef53l283 24 20 those those DT cord-333672-ef53l283 24 21 with with IN cord-333672-ef53l283 24 22 COVID-19 COVID-19 NNP cord-333672-ef53l283 24 23 as as RB cord-333672-ef53l283 24 24 well well RB cord-333672-ef53l283 24 25 as as IN cord-333672-ef53l283 24 26 other other JJ cord-333672-ef53l283 24 27 coronavirus coronavirus NN cord-333672-ef53l283 24 28 and and CC cord-333672-ef53l283 24 29 influenza influenza NN cord-333672-ef53l283 24 30 infections infection NNS cord-333672-ef53l283 24 31 ( ( -LRB- cord-333672-ef53l283 24 32 10 10 CD cord-333672-ef53l283 24 33 ) ) -RRB- cord-333672-ef53l283 24 34 ( ( -LRB- cord-333672-ef53l283 24 35 11 11 CD cord-333672-ef53l283 24 36 ) ) -RRB- cord-333672-ef53l283 24 37 ( ( -LRB- cord-333672-ef53l283 24 38 12 12 CD cord-333672-ef53l283 24 39 ) ) -RRB- cord-333672-ef53l283 24 40 ( ( -LRB- cord-333672-ef53l283 24 41 13 13 CD cord-333672-ef53l283 24 42 ) ) -RRB- cord-333672-ef53l283 24 43 ( ( -LRB- cord-333672-ef53l283 24 44 14 14 CD cord-333672-ef53l283 24 45 ) ) -RRB- cord-333672-ef53l283 25 1 ( ( -LRB- cord-333672-ef53l283 25 2 15 15 CD cord-333672-ef53l283 25 3 ) ) -RRB- cord-333672-ef53l283 25 4 ( ( -LRB- cord-333672-ef53l283 25 5 16 16 CD cord-333672-ef53l283 25 6 ) ) -RRB- cord-333672-ef53l283 25 7 ( ( -LRB- cord-333672-ef53l283 25 8 17 17 CD cord-333672-ef53l283 25 9 ) ) -RRB- cord-333672-ef53l283 25 10 . . . cord-333672-ef53l283 26 1 As as IN cord-333672-ef53l283 26 2 shift shift NN cord-333672-ef53l283 26 3 workers worker NNS cord-333672-ef53l283 26 4 often often RB cord-333672-ef53l283 26 5 work work VBP cord-333672-ef53l283 26 6 jobs job NNS cord-333672-ef53l283 26 7 considered consider VBN cord-333672-ef53l283 26 8 essential essential JJ cord-333672-ef53l283 26 9 during during IN cord-333672-ef53l283 26 10 the the DT cord-333672-ef53l283 26 11 COVID-19 COVID-19 NNP cord-333672-ef53l283 26 12 pandemic pandemic NN cord-333672-ef53l283 26 13 , , , cord-333672-ef53l283 26 14 improving improve VBG cord-333672-ef53l283 26 15 the the DT cord-333672-ef53l283 26 16 health health NN cord-333672-ef53l283 26 17 of of IN cord-333672-ef53l283 26 18 shift shift NN cord-333672-ef53l283 26 19 workers worker NNS cord-333672-ef53l283 26 20 should should MD cord-333672-ef53l283 26 21 become become VB cord-333672-ef53l283 26 22 a a DT cord-333672-ef53l283 26 23 key key JJ cord-333672-ef53l283 26 24 part part NN cord-333672-ef53l283 26 25 of of IN cord-333672-ef53l283 26 26 current current JJ cord-333672-ef53l283 26 27 and and CC cord-333672-ef53l283 26 28 future future JJ cord-333672-ef53l283 26 29 pandemic pandemic NN cord-333672-ef53l283 26 30 preparedness preparedness NN cord-333672-ef53l283 26 31 . . . cord-333672-ef53l283 27 1 Importantly importantly RB cord-333672-ef53l283 27 2 , , , cord-333672-ef53l283 27 3 however however RB cord-333672-ef53l283 27 4 , , , cord-333672-ef53l283 27 5 at at IN cord-333672-ef53l283 27 6 present present NN cord-333672-ef53l283 27 7 there there EX cord-333672-ef53l283 27 8 is be VBZ cord-333672-ef53l283 27 9 no no DT cord-333672-ef53l283 27 10 strong strong JJ cord-333672-ef53l283 27 11 evidence evidence NN cord-333672-ef53l283 27 12 that that IN cord-333672-ef53l283 27 13 people people NNS cord-333672-ef53l283 27 14 fully fully RB cord-333672-ef53l283 27 15 adapt adapt VBP cord-333672-ef53l283 27 16 to to TO cord-333672-ef53l283 27 17 shift shift VB cord-333672-ef53l283 27 18 work work NN cord-333672-ef53l283 27 19 ( ( -LRB- cord-333672-ef53l283 27 20 18 18 CD cord-333672-ef53l283 27 21 ) ) -RRB- cord-333672-ef53l283 27 22 . . . cord-333672-ef53l283 28 1 And and CC cord-333672-ef53l283 28 2 considering consider VBG cord-333672-ef53l283 28 3 that that IN cord-333672-ef53l283 28 4 the the DT cord-333672-ef53l283 28 5 unconventional unconventional JJ cord-333672-ef53l283 28 6 schedules schedule NNS cord-333672-ef53l283 28 7 of of IN cord-333672-ef53l283 28 8 shift shift NN cord-333672-ef53l283 28 9 workers worker NNS cord-333672-ef53l283 28 10 also also RB cord-333672-ef53l283 28 11 interrupt interrupt VBP cord-333672-ef53l283 28 12 the the DT cord-333672-ef53l283 28 13 lives life NNS cord-333672-ef53l283 28 14 of of IN cord-333672-ef53l283 28 15 cohabiting cohabit VBG cord-333672-ef53l283 28 16 non non JJ cord-333672-ef53l283 28 17 - - JJ cord-333672-ef53l283 28 18 shift shift JJ cord-333672-ef53l283 28 19 workers worker NNS cord-333672-ef53l283 28 20 , , , cord-333672-ef53l283 28 21 the the DT cord-333672-ef53l283 28 22 burden burden NN cord-333672-ef53l283 28 23 of of IN cord-333672-ef53l283 28 24 shift shift NN cord-333672-ef53l283 28 25 work work NN cord-333672-ef53l283 28 26 is be VBZ cord-333672-ef53l283 28 27 greater great JJR cord-333672-ef53l283 28 28 still still RB cord-333672-ef53l283 28 29 . . . cord-333672-ef53l283 29 1 The the DT cord-333672-ef53l283 29 2 purpose purpose NN cord-333672-ef53l283 29 3 of of IN cord-333672-ef53l283 29 4 this this DT cord-333672-ef53l283 29 5 manuscript manuscript NN cord-333672-ef53l283 29 6 is be VBZ cord-333672-ef53l283 29 7 therefore therefore RB cord-333672-ef53l283 29 8 to to TO cord-333672-ef53l283 29 9 summarise summarise VB cord-333672-ef53l283 29 10 some some DT cord-333672-ef53l283 29 11 ways way NNS cord-333672-ef53l283 29 12 by by IN cord-333672-ef53l283 29 13 which which WDT cord-333672-ef53l283 29 14 we -PRON- PRP cord-333672-ef53l283 29 15 might may MD cord-333672-ef53l283 29 16 be be VB cord-333672-ef53l283 29 17 able able JJ cord-333672-ef53l283 29 18 to to TO cord-333672-ef53l283 29 19 reduce reduce VB cord-333672-ef53l283 29 20 this this DT cord-333672-ef53l283 29 21 burden burden NN cord-333672-ef53l283 29 22 . . . cord-333672-ef53l283 30 1 Optimising optimise VBG cord-333672-ef53l283 30 2 shift shift NN cord-333672-ef53l283 30 3 work work NN cord-333672-ef53l283 30 4 schedules schedule NNS cord-333672-ef53l283 30 5 is be VBZ cord-333672-ef53l283 30 6 fundamental fundamental JJ cord-333672-ef53l283 30 7 to to IN cord-333672-ef53l283 30 8 the the DT cord-333672-ef53l283 30 9 health health NN cord-333672-ef53l283 30 10 and and CC cord-333672-ef53l283 30 11 productivity productivity NN cord-333672-ef53l283 30 12 of of IN cord-333672-ef53l283 30 13 shift shift NN cord-333672-ef53l283 30 14 workers worker NNS cord-333672-ef53l283 30 15 . . . cord-333672-ef53l283 31 1 In in IN cord-333672-ef53l283 31 2 general general JJ cord-333672-ef53l283 31 3 , , , cord-333672-ef53l283 31 4 it -PRON- PRP cord-333672-ef53l283 31 5 appears appear VBZ cord-333672-ef53l283 31 6 that that IN cord-333672-ef53l283 31 7 most most JJS cord-333672-ef53l283 31 8 shift shift NN cord-333672-ef53l283 31 9 workers worker NNS cord-333672-ef53l283 31 10 tolerate tolerate VBP cord-333672-ef53l283 31 11 rapid rapid JJ cord-333672-ef53l283 31 12 , , , cord-333672-ef53l283 31 13 forward forward RB cord-333672-ef53l283 31 14 ( ( -LRB- cord-333672-ef53l283 31 15 clockwise clockwise NN cord-333672-ef53l283 31 16 ) ) -RRB- cord-333672-ef53l283 31 17 rotation rotation NN cord-333672-ef53l283 31 18 schedules schedule NNS cord-333672-ef53l283 31 19 best best RB cord-333672-ef53l283 31 20 ( ( -LRB- cord-333672-ef53l283 31 21 5 5 CD cord-333672-ef53l283 31 22 ) ) -RRB- cord-333672-ef53l283 31 23 . . . cord-333672-ef53l283 32 1 To to TO cord-333672-ef53l283 32 2 support support VB cord-333672-ef53l283 32 3 worker worker NN cord-333672-ef53l283 32 4 wellbeing wellbeing NN cord-333672-ef53l283 32 5 , , , cord-333672-ef53l283 32 6 these these DT cord-333672-ef53l283 32 7 shifts shift NNS cord-333672-ef53l283 32 8 should should MD cord-333672-ef53l283 32 9 each each DT cord-333672-ef53l283 32 10 last last VB cord-333672-ef53l283 32 11 no no RB cord-333672-ef53l283 32 12 longer long RBR cord-333672-ef53l283 32 13 than than IN cord-333672-ef53l283 32 14 10 10 CD cord-333672-ef53l283 32 15 h h NN cord-333672-ef53l283 32 16 , , , cord-333672-ef53l283 32 17 have have VBP cord-333672-ef53l283 32 18 at at RB cord-333672-ef53l283 32 19 least least RBS cord-333672-ef53l283 32 20 11 11 CD cord-333672-ef53l283 32 21 h h NN cord-333672-ef53l283 32 22 of of IN cord-333672-ef53l283 32 23 recovery recovery NN cord-333672-ef53l283 32 24 between between IN cord-333672-ef53l283 32 25 them -PRON- PRP cord-333672-ef53l283 32 26 , , , cord-333672-ef53l283 32 27 and and CC cord-333672-ef53l283 32 28 amount amount VB cord-333672-ef53l283 32 29 to to IN cord-333672-ef53l283 32 30 no no DT cord-333672-ef53l283 32 31 more more JJR cord-333672-ef53l283 32 32 than than IN cord-333672-ef53l283 32 33 60 60 CD cord-333672-ef53l283 32 34 h h NN cord-333672-ef53l283 32 35 of of IN cord-333672-ef53l283 32 36 work work NN cord-333672-ef53l283 32 37 per per IN cord-333672-ef53l283 32 38 week week NN cord-333672-ef53l283 32 39 ( ( -LRB- cord-333672-ef53l283 32 40 5 5 CD cord-333672-ef53l283 32 41 ) ) -RRB- cord-333672-ef53l283 32 42 . . . cord-333672-ef53l283 33 1 To to TO cord-333672-ef53l283 33 2 hone hone VB cord-333672-ef53l283 33 3 shift shift VB cord-333672-ef53l283 33 4 work work NN cord-333672-ef53l283 33 5 schedules schedule NNS cord-333672-ef53l283 33 6 for for IN cord-333672-ef53l283 33 7 individual individual JJ cord-333672-ef53l283 33 8 workers worker NNS cord-333672-ef53l283 33 9 , , , cord-333672-ef53l283 33 10 workers worker NNS cord-333672-ef53l283 33 11 may may MD cord-333672-ef53l283 33 12 benefit benefit VB cord-333672-ef53l283 33 13 from from IN cord-333672-ef53l283 33 14 having have VBG cord-333672-ef53l283 33 15 some some DT cord-333672-ef53l283 33 16 control control NN cord-333672-ef53l283 33 17 of of IN cord-333672-ef53l283 33 18 their -PRON- PRP$ cord-333672-ef53l283 33 19 schedules schedule NNS cord-333672-ef53l283 33 20 . . . cord-333672-ef53l283 34 1 This this DT cord-333672-ef53l283 34 2 autonomy autonomy NN cord-333672-ef53l283 34 3 helps help VBZ cord-333672-ef53l283 34 4 account account VB cord-333672-ef53l283 34 5 for for IN cord-333672-ef53l283 34 6 differences difference NNS cord-333672-ef53l283 34 7 between between IN cord-333672-ef53l283 34 8 people people NNS cord-333672-ef53l283 34 9 in in IN cord-333672-ef53l283 34 10 nonwork nonwork JJ cord-333672-ef53l283 34 11 responsibilities responsibility NNS cord-333672-ef53l283 34 12 , , , cord-333672-ef53l283 34 13 tolerance tolerance NN cord-333672-ef53l283 34 14 to to TO cord-333672-ef53l283 34 15 shift shift VB cord-333672-ef53l283 34 16 work work NN cord-333672-ef53l283 34 17 , , , cord-333672-ef53l283 34 18 and and CC cord-333672-ef53l283 34 19 commuting commute VBG cord-333672-ef53l283 34 20 to to IN cord-333672-ef53l283 34 21 and and CC cord-333672-ef53l283 34 22 from from IN cord-333672-ef53l283 34 23 work work NN cord-333672-ef53l283 34 24 . . . cord-333672-ef53l283 35 1 Chronotype Chronotype NNP cord-333672-ef53l283 35 2 is be VBZ cord-333672-ef53l283 35 3 another another DT cord-333672-ef53l283 35 4 tailoring tailoring NN cord-333672-ef53l283 35 5 variable variable NN cord-333672-ef53l283 35 6 that that WDT cord-333672-ef53l283 35 7 is be VBZ cord-333672-ef53l283 35 8 particularly particularly RB cord-333672-ef53l283 35 9 germane germane JJ cord-333672-ef53l283 35 10 to to IN cord-333672-ef53l283 35 11 optimising optimise VBG cord-333672-ef53l283 35 12 shift shift JJ cord-333672-ef53l283 35 13 work work NN cord-333672-ef53l283 35 14 schedules schedule NNS cord-333672-ef53l283 35 15 . . . cord-333672-ef53l283 36 1 Chronotype Chronotype NNP cord-333672-ef53l283 36 2 is be VBZ cord-333672-ef53l283 36 3 defined define VBN cord-333672-ef53l283 36 4 as as IN cord-333672-ef53l283 36 5 interindividual interindividual JJ cord-333672-ef53l283 36 6 differences difference NNS cord-333672-ef53l283 36 7 in in IN cord-333672-ef53l283 36 8 the the DT cord-333672-ef53l283 36 9 phenotypic phenotypic JJ cord-333672-ef53l283 36 10 expression expression NN cord-333672-ef53l283 36 11 of of IN cord-333672-ef53l283 36 12 behavioural behavioural JJ cord-333672-ef53l283 36 13 outputs output NNS cord-333672-ef53l283 36 14 regulated regulate VBN cord-333672-ef53l283 36 15 by by IN cord-333672-ef53l283 36 16 the the DT cord-333672-ef53l283 36 17 circadian circadian NN cord-333672-ef53l283 36 18 system system NN cord-333672-ef53l283 36 19 ( ( -LRB- cord-333672-ef53l283 36 20 19 19 CD cord-333672-ef53l283 36 21 ) ) -RRB- cord-333672-ef53l283 36 22 , , , cord-333672-ef53l283 36 23 the the DT cord-333672-ef53l283 36 24 most most RBS cord-333672-ef53l283 36 25 conspicuous conspicuous JJ cord-333672-ef53l283 36 26 of of IN cord-333672-ef53l283 36 27 which which WDT cord-333672-ef53l283 36 28 is be VBZ cord-333672-ef53l283 36 29 the the DT cord-333672-ef53l283 36 30 timing timing NN cord-333672-ef53l283 36 31 of of IN cord-333672-ef53l283 36 32 the the DT cord-333672-ef53l283 36 33 sleep sleep NN cord-333672-ef53l283 36 34 / / SYM cord-333672-ef53l283 36 35 wake wake VBP cord-333672-ef53l283 36 36 cycle cycle NN cord-333672-ef53l283 36 37 , , , cord-333672-ef53l283 36 38 and and CC cord-333672-ef53l283 36 39 in in IN cord-333672-ef53l283 36 40 industrialised industrialised JJ cord-333672-ef53l283 36 41 societies society NNS cord-333672-ef53l283 36 42 there there RB cord-333672-ef53l283 36 43 exist exist VBP cord-333672-ef53l283 36 44 large large JJ cord-333672-ef53l283 36 45 differences difference NNS cord-333672-ef53l283 36 46 between between IN cord-333672-ef53l283 36 47 individuals individual NNS cord-333672-ef53l283 36 48 in in IN cord-333672-ef53l283 36 49 their -PRON- PRP$ cord-333672-ef53l283 36 50 chronotypes chronotype NNS cord-333672-ef53l283 36 51 ( ( -LRB- cord-333672-ef53l283 36 52 20 20 CD cord-333672-ef53l283 36 53 ) ) -RRB- cord-333672-ef53l283 36 54 . . . cord-333672-ef53l283 37 1 Chronotype Chronotype NNP cord-333672-ef53l283 37 2 appears appear VBZ cord-333672-ef53l283 37 3 to to TO cord-333672-ef53l283 37 4 modify modify VB cord-333672-ef53l283 37 5 the the DT cord-333672-ef53l283 37 6 association association NN cord-333672-ef53l283 37 7 between between IN cord-333672-ef53l283 37 8 shift shift JJ cord-333672-ef53l283 37 9 work work NN cord-333672-ef53l283 37 10 schedules schedule NNS cord-333672-ef53l283 37 11 and and CC cord-333672-ef53l283 37 12 risk risk NN cord-333672-ef53l283 37 13 of of IN cord-333672-ef53l283 37 14 health health NN cord-333672-ef53l283 37 15 problems problem NNS cord-333672-ef53l283 37 16 ( ( -LRB- cord-333672-ef53l283 37 17 21 21 CD cord-333672-ef53l283 37 18 ) ) -RRB- cord-333672-ef53l283 37 19 , , , cord-333672-ef53l283 37 20 such such JJ cord-333672-ef53l283 37 21 that that IN cord-333672-ef53l283 37 22 the the DT cord-333672-ef53l283 37 23 health health NN cord-333672-ef53l283 37 24 of of IN cord-333672-ef53l283 37 25 early early JJ cord-333672-ef53l283 37 26 chronotypes chronotypes NNP cord-333672-ef53l283 37 27 may may MD cord-333672-ef53l283 37 28 be be VB cord-333672-ef53l283 37 29 especially especially RB cord-333672-ef53l283 37 30 negatively negatively RB cord-333672-ef53l283 37 31 affected affect VBN cord-333672-ef53l283 37 32 by by IN cord-333672-ef53l283 37 33 working work VBG cord-333672-ef53l283 37 34 night night NN cord-333672-ef53l283 37 35 shifts shift NNS cord-333672-ef53l283 37 36 ( ( -LRB- cord-333672-ef53l283 37 37 22 22 CD cord-333672-ef53l283 37 38 ) ) -RRB- cord-333672-ef53l283 37 39 , , , cord-333672-ef53l283 37 40 whereas whereas IN cord-333672-ef53l283 37 41 late late JJ cord-333672-ef53l283 37 42 chronotypes chronotypes NNP cord-333672-ef53l283 37 43 find find VBP cord-333672-ef53l283 37 44 working work VBG cord-333672-ef53l283 37 45 morning morning NN cord-333672-ef53l283 37 46 shifts shift NNS cord-333672-ef53l283 37 47 particularly particularly RB cord-333672-ef53l283 37 48 problematic problematic JJ cord-333672-ef53l283 37 49 ( ( -LRB- cord-333672-ef53l283 37 50 23 23 CD cord-333672-ef53l283 37 51 ) ) -RRB- cord-333672-ef53l283 37 52 . . . cord-333672-ef53l283 38 1 While while IN cord-333672-ef53l283 38 2 it -PRON- PRP cord-333672-ef53l283 38 3 is be VBZ cord-333672-ef53l283 38 4 not not RB cord-333672-ef53l283 38 5 clear clear JJ cord-333672-ef53l283 38 6 precisely precisely RB cord-333672-ef53l283 38 7 why why WRB cord-333672-ef53l283 38 8 this this DT cord-333672-ef53l283 38 9 interaction interaction NN cord-333672-ef53l283 38 10 exists exist VBZ cord-333672-ef53l283 38 11 , , , cord-333672-ef53l283 38 12 shift shift VB cord-333672-ef53l283 38 13 workers worker NNS cord-333672-ef53l283 38 14 who who WP cord-333672-ef53l283 38 15 have have VBP cord-333672-ef53l283 38 16 closer close JJR cord-333672-ef53l283 38 17 alignment alignment NN cord-333672-ef53l283 38 18 between between IN cord-333672-ef53l283 38 19 their -PRON- PRP$ cord-333672-ef53l283 38 20 chronotypes chronotype NNS cord-333672-ef53l283 38 21 and and CC cord-333672-ef53l283 38 22 their -PRON- PRP$ cord-333672-ef53l283 38 23 work work NN cord-333672-ef53l283 38 24 schedules schedule NNS cord-333672-ef53l283 38 25 appear appear VBP cord-333672-ef53l283 38 26 to to TO cord-333672-ef53l283 38 27 have have VB cord-333672-ef53l283 38 28 more more RBR cord-333672-ef53l283 38 29 robust robust JJ cord-333672-ef53l283 38 30 melatonin melatonin NN cord-333672-ef53l283 38 31 rhythms rhythm NNS cord-333672-ef53l283 38 32 than than IN cord-333672-ef53l283 38 33 their -PRON- PRP$ cord-333672-ef53l283 38 34 fellow fellow JJ cord-333672-ef53l283 38 35 shift shift NN cord-333672-ef53l283 38 36 workers worker NNS cord-333672-ef53l283 38 37 , , , cord-333672-ef53l283 38 38 suggesting suggest VBG cord-333672-ef53l283 38 39 that that IN cord-333672-ef53l283 38 40 they -PRON- PRP cord-333672-ef53l283 38 41 have have VBP cord-333672-ef53l283 38 42 better well JJR cord-333672-ef53l283 38 43 circadian circadian NN cord-333672-ef53l283 38 44 system system NN cord-333672-ef53l283 38 45 function function NN cord-333672-ef53l283 38 46 ( ( -LRB- cord-333672-ef53l283 38 47 24 24 CD cord-333672-ef53l283 38 48 ) ) -RRB- cord-333672-ef53l283 38 49 . . . cord-333672-ef53l283 39 1 Shift shift JJ cord-333672-ef53l283 39 2 workers worker NNS cord-333672-ef53l283 39 3 who who WP cord-333672-ef53l283 39 4 have have VBP cord-333672-ef53l283 39 5 chronotypes chronotype NNS cord-333672-ef53l283 39 6 that that WDT cord-333672-ef53l283 39 7 are be VBP cord-333672-ef53l283 39 8 better well RBR cord-333672-ef53l283 39 9 matched match VBN cord-333672-ef53l283 39 10 to to IN cord-333672-ef53l283 39 11 their -PRON- PRP$ cord-333672-ef53l283 39 12 work work NN cord-333672-ef53l283 39 13 schedules schedule NNS cord-333672-ef53l283 39 14 may may MD cord-333672-ef53l283 39 15 also also RB cord-333672-ef53l283 39 16 sleep sleep VB cord-333672-ef53l283 39 17 better well RBR cord-333672-ef53l283 39 18 ( ( -LRB- cord-333672-ef53l283 39 19 23 23 CD cord-333672-ef53l283 39 20 ) ) -RRB- cord-333672-ef53l283 39 21 , , , cord-333672-ef53l283 39 22 and and CC cord-333672-ef53l283 39 23 it -PRON- PRP cord-333672-ef53l283 39 24 is be VBZ cord-333672-ef53l283 39 25 increasingly increasingly RB cord-333672-ef53l283 39 26 clear clear JJ cord-333672-ef53l283 39 27 that that IN cord-333672-ef53l283 39 28 circadian circadian NN cord-333672-ef53l283 39 29 system system NN cord-333672-ef53l283 39 30 and and CC cord-333672-ef53l283 39 31 sleep sleep NN cord-333672-ef53l283 39 32 health health NN cord-333672-ef53l283 39 33 are be VBP cord-333672-ef53l283 39 34 essential essential JJ cord-333672-ef53l283 39 35 to to IN cord-333672-ef53l283 39 36 perhaps perhaps RB cord-333672-ef53l283 39 37 all all DT cord-333672-ef53l283 39 38 facets facet NNS cord-333672-ef53l283 39 39 of of IN cord-333672-ef53l283 39 40 human human JJ cord-333672-ef53l283 39 41 health health NN cord-333672-ef53l283 39 42 ( ( -LRB- cord-333672-ef53l283 39 43 25 25 CD cord-333672-ef53l283 39 44 , , , cord-333672-ef53l283 39 45 26 26 CD cord-333672-ef53l283 39 46 ) ) -RRB- cord-333672-ef53l283 39 47 . . . cord-333672-ef53l283 40 1 The the DT cord-333672-ef53l283 40 2 period period NN cord-333672-ef53l283 40 3 of of IN cord-333672-ef53l283 40 4 each each DT cord-333672-ef53l283 40 5 individual individual NN cord-333672-ef53l283 40 6 's 's POS cord-333672-ef53l283 40 7 circadian circadian NN cord-333672-ef53l283 40 8 system system NN cord-333672-ef53l283 40 9 is be VBZ cord-333672-ef53l283 40 10 one one CD cord-333672-ef53l283 40 11 determinant determinant NN cord-333672-ef53l283 40 12 of of IN cord-333672-ef53l283 40 13 his -PRON- PRP$ cord-333672-ef53l283 40 14 or or CC cord-333672-ef53l283 40 15 her -PRON- PRP$ cord-333672-ef53l283 40 16 chronotype chronotype NN cord-333672-ef53l283 40 17 . . . cord-333672-ef53l283 41 1 In in IN cord-333672-ef53l283 41 2 the the DT cord-333672-ef53l283 41 3 absence absence NN cord-333672-ef53l283 41 4 of of IN cord-333672-ef53l283 41 5 time time NN cord-333672-ef53l283 41 6 cues cue NNS cord-333672-ef53l283 41 7 ( ( -LRB- cord-333672-ef53l283 41 8 zeitgebers zeitgebers NNP cord-333672-ef53l283 41 9 ) ) -RRB- cord-333672-ef53l283 41 10 , , , cord-333672-ef53l283 41 11 the the DT cord-333672-ef53l283 41 12 free free RB cord-333672-ef53l283 41 13 - - HYPH cord-333672-ef53l283 41 14 running run VBG cord-333672-ef53l283 41 15 period period NN cord-333672-ef53l283 41 16 of of IN cord-333672-ef53l283 41 17 the the DT cord-333672-ef53l283 41 18 human human JJ cord-333672-ef53l283 41 19 circadian circadian NN cord-333672-ef53l283 41 20 system system NN cord-333672-ef53l283 41 21 is be VBZ cord-333672-ef53l283 41 22 slightly slightly RB cord-333672-ef53l283 41 23 longer long JJR cord-333672-ef53l283 41 24 than than IN cord-333672-ef53l283 41 25 24 24 CD cord-333672-ef53l283 41 26 h h NN cord-333672-ef53l283 41 27 , , , cord-333672-ef53l283 41 28 on on IN cord-333672-ef53l283 41 29 average average JJ cord-333672-ef53l283 41 30 ( ( -LRB- cord-333672-ef53l283 41 31 27 27 CD cord-333672-ef53l283 41 32 ) ) -RRB- cord-333672-ef53l283 41 33 . . . cord-333672-ef53l283 42 1 The the DT cord-333672-ef53l283 42 2 circadian circadian NN cord-333672-ef53l283 42 3 system system NN cord-333672-ef53l283 42 4 therefore therefore RB cord-333672-ef53l283 42 5 needs need VBZ cord-333672-ef53l283 42 6 to to TO cord-333672-ef53l283 42 7 be be VB cord-333672-ef53l283 42 8 synchronised synchronise VBN cord-333672-ef53l283 42 9 ( ( -LRB- cord-333672-ef53l283 42 10 entrained entrain VBN cord-333672-ef53l283 42 11 ) ) -RRB- cord-333672-ef53l283 42 12 each each DT cord-333672-ef53l283 42 13 day day NN cord-333672-ef53l283 42 14 with with IN cord-333672-ef53l283 42 15 the the DT cord-333672-ef53l283 42 16 24-h 24-h JJ cord-333672-ef53l283 42 17 day day NN cord-333672-ef53l283 42 18 , , , cord-333672-ef53l283 42 19 and and CC cord-333672-ef53l283 42 20 shift shift VB cord-333672-ef53l283 43 1 work work NN cord-333672-ef53l283 43 2 complicates complicate VBZ cord-333672-ef53l283 43 3 this this DT cord-333672-ef53l283 43 4 process process NN cord-333672-ef53l283 43 5 . . . cord-333672-ef53l283 44 1 Retinal retinal JJ cord-333672-ef53l283 44 2 light light JJ cord-333672-ef53l283 44 3 exposure exposure NN cord-333672-ef53l283 44 4 is be VBZ cord-333672-ef53l283 44 5 generally generally RB cord-333672-ef53l283 44 6 regarded regard VBN cord-333672-ef53l283 44 7 as as IN cord-333672-ef53l283 44 8 the the DT cord-333672-ef53l283 44 9 most most RBS cord-333672-ef53l283 44 10 important important JJ cord-333672-ef53l283 44 11 stimulus stimulus NN cord-333672-ef53l283 44 12 in in IN cord-333672-ef53l283 44 13 entraining entrain VBG cord-333672-ef53l283 44 14 the the DT cord-333672-ef53l283 44 15 human human JJ cord-333672-ef53l283 44 16 circadian circadian NN cord-333672-ef53l283 44 17 system system NN cord-333672-ef53l283 44 18 ( ( -LRB- cord-333672-ef53l283 44 19 28 28 CD cord-333672-ef53l283 44 20 ) ) -RRB- cord-333672-ef53l283 44 21 , , , cord-333672-ef53l283 44 22 and and CC cord-333672-ef53l283 44 23 changes change NNS cord-333672-ef53l283 44 24 in in IN cord-333672-ef53l283 44 25 patterns pattern NNS cord-333672-ef53l283 44 26 of of IN cord-333672-ef53l283 44 27 light light JJ cord-333672-ef53l283 44 28 exposure exposure NN cord-333672-ef53l283 44 29 can can MD cord-333672-ef53l283 44 30 rapidly rapidly RB cord-333672-ef53l283 44 31 and and CC cord-333672-ef53l283 44 32 substantially substantially RB cord-333672-ef53l283 44 33 shift shift VB cord-333672-ef53l283 44 34 circadian circadian NN cord-333672-ef53l283 44 35 system system NN cord-333672-ef53l283 44 36 timing timing NN cord-333672-ef53l283 44 37 ( ( -LRB- cord-333672-ef53l283 44 38 phase phase NN cord-333672-ef53l283 44 39 ) ) -RRB- cord-333672-ef53l283 44 40 . . . cord-333672-ef53l283 45 1 This this DT cord-333672-ef53l283 45 2 is be VBZ cord-333672-ef53l283 45 3 especially especially RB cord-333672-ef53l283 45 4 true true JJ cord-333672-ef53l283 45 5 of of IN cord-333672-ef53l283 45 6 short short JJ cord-333672-ef53l283 45 7 - - HYPH cord-333672-ef53l283 45 8 wavelength wavelength NN cord-333672-ef53l283 45 9 light light NN cord-333672-ef53l283 45 10 , , , cord-333672-ef53l283 45 11 which which WDT cord-333672-ef53l283 45 12 most most RBS cord-333672-ef53l283 45 13 potently potently RB cord-333672-ef53l283 45 14 suppresses suppress VBZ cord-333672-ef53l283 45 15 melatonin melatonin NN cord-333672-ef53l283 45 16 synthesis synthesis NN cord-333672-ef53l283 45 17 ( ( -LRB- cord-333672-ef53l283 45 18 29 29 CD cord-333672-ef53l283 45 19 ) ) -RRB- cord-333672-ef53l283 45 20 . . . cord-333672-ef53l283 46 1 Exposure exposure NN cord-333672-ef53l283 46 2 to to IN cord-333672-ef53l283 46 3 such such JJ cord-333672-ef53l283 46 4 light light NN cord-333672-ef53l283 46 5 in in IN cord-333672-ef53l283 46 6 the the DT cord-333672-ef53l283 46 7 biological biological JJ cord-333672-ef53l283 46 8 morning morning NN cord-333672-ef53l283 46 9 tends tend VBZ cord-333672-ef53l283 46 10 to to TO cord-333672-ef53l283 46 11 advance advance VB cord-333672-ef53l283 46 12 circadian circadian NN cord-333672-ef53l283 46 13 phase phase NN cord-333672-ef53l283 46 14 , , , cord-333672-ef53l283 46 15 whereas whereas IN cord-333672-ef53l283 46 16 exposure exposure NN cord-333672-ef53l283 46 17 to to IN cord-333672-ef53l283 46 18 such such JJ cord-333672-ef53l283 46 19 light light NN cord-333672-ef53l283 46 20 in in IN cord-333672-ef53l283 46 21 the the DT cord-333672-ef53l283 46 22 late late JJ cord-333672-ef53l283 46 23 biological biological JJ cord-333672-ef53l283 46 24 evening evening NN cord-333672-ef53l283 46 25 tends tend VBZ cord-333672-ef53l283 46 26 to to TO cord-333672-ef53l283 46 27 delay delay VB cord-333672-ef53l283 46 28 circadian circadian NN cord-333672-ef53l283 46 29 phase phase NN cord-333672-ef53l283 46 30 . . . cord-333672-ef53l283 47 1 The the DT cord-333672-ef53l283 47 2 implication implication NN cord-333672-ef53l283 47 3 of of IN cord-333672-ef53l283 47 4 this this DT cord-333672-ef53l283 47 5 is be VBZ cord-333672-ef53l283 47 6 that that IN cord-333672-ef53l283 47 7 it -PRON- PRP cord-333672-ef53l283 47 8 is be VBZ cord-333672-ef53l283 47 9 possible possible JJ cord-333672-ef53l283 47 10 to to TO cord-333672-ef53l283 47 11 bolster bolster VB cord-333672-ef53l283 47 12 how how WRB cord-333672-ef53l283 47 13 well well JJ cord-333672-ef53l283 47 14 - - HYPH cord-333672-ef53l283 47 15 shift shift NN cord-333672-ef53l283 47 16 workers worker NNS cord-333672-ef53l283 47 17 adapt adapt VBP cord-333672-ef53l283 47 18 to to TO cord-333672-ef53l283 47 19 work work VB cord-333672-ef53l283 47 20 schedules schedule NNS cord-333672-ef53l283 47 21 through through IN cord-333672-ef53l283 47 22 timely timely JJ cord-333672-ef53l283 47 23 use use NN cord-333672-ef53l283 47 24 of of IN cord-333672-ef53l283 47 25 means mean NNS cord-333672-ef53l283 47 26 to to TO cord-333672-ef53l283 47 27 increase increase VB cord-333672-ef53l283 47 28 exposure exposure NN cord-333672-ef53l283 47 29 to to IN cord-333672-ef53l283 47 30 high high JJ cord-333672-ef53l283 47 31 - - HYPH cord-333672-ef53l283 47 32 intensity intensity NN cord-333672-ef53l283 47 33 , , , cord-333672-ef53l283 47 34 shortwavelength shortwavelength NN cord-333672-ef53l283 47 35 light light NN cord-333672-ef53l283 47 36 at at IN cord-333672-ef53l283 47 37 specific specific JJ cord-333672-ef53l283 47 38 times time NNS cord-333672-ef53l283 47 39 of of IN cord-333672-ef53l283 47 40 day day NN cord-333672-ef53l283 48 1 ( ( -LRB- cord-333672-ef53l283 48 2 e.g. e.g. RB cord-333672-ef53l283 48 3 , , , cord-333672-ef53l283 48 4 by by IN cord-333672-ef53l283 48 5 using use VBG cord-333672-ef53l283 48 6 lighttherapy lighttherapy NNP cord-333672-ef53l283 48 7 lamps lamp NNS cord-333672-ef53l283 48 8 ) ) -RRB- cord-333672-ef53l283 48 9 and and CC cord-333672-ef53l283 48 10 means mean VBZ cord-333672-ef53l283 48 11 to to TO cord-333672-ef53l283 48 12 reduce reduce VB cord-333672-ef53l283 48 13 exposure exposure NN cord-333672-ef53l283 48 14 to to IN cord-333672-ef53l283 48 15 such such JJ cord-333672-ef53l283 48 16 light light NN cord-333672-ef53l283 48 17 at at IN cord-333672-ef53l283 48 18 specific specific JJ cord-333672-ef53l283 48 19 times time NNS cord-333672-ef53l283 48 20 of of IN cord-333672-ef53l283 48 21 day day NN cord-333672-ef53l283 48 22 ( ( -LRB- cord-333672-ef53l283 48 23 e.g. e.g. RB cord-333672-ef53l283 48 24 , , , cord-333672-ef53l283 48 25 " " '' cord-333672-ef53l283 48 26 blue blue RB cord-333672-ef53l283 48 27 - - HYPH cord-333672-ef53l283 48 28 blocking block VBG cord-333672-ef53l283 48 29 " " `` cord-333672-ef53l283 48 30 glasses glass NNS cord-333672-ef53l283 48 31 and and CC cord-333672-ef53l283 48 32 blue blue JJ cord-333672-ef53l283 48 33 - - HYPH cord-333672-ef53l283 48 34 light light NN cord-333672-ef53l283 48 35 filtering filter VBG cord-333672-ef53l283 48 36 apps app NNS cord-333672-ef53l283 48 37 on on IN cord-333672-ef53l283 48 38 electronic electronic JJ cord-333672-ef53l283 48 39 devices device NNS cord-333672-ef53l283 48 40 ) ) -RRB- cord-333672-ef53l283 48 41 . . . cord-333672-ef53l283 49 1 While while IN cord-333672-ef53l283 49 2 not not RB cord-333672-ef53l283 49 3 all all DT cord-333672-ef53l283 49 4 studies study NNS cord-333672-ef53l283 49 5 that that WDT cord-333672-ef53l283 49 6 have have VBP cord-333672-ef53l283 49 7 used use VBN cord-333672-ef53l283 49 8 interventions intervention NNS cord-333672-ef53l283 49 9 to to TO cord-333672-ef53l283 49 10 modify modify VB cord-333672-ef53l283 49 11 exposure exposure NN cord-333672-ef53l283 49 12 to to IN cord-333672-ef53l283 49 13 light light NN cord-333672-ef53l283 49 14 in in IN cord-333672-ef53l283 49 15 shift shift NN cord-333672-ef53l283 49 16 workers worker NNS cord-333672-ef53l283 49 17 have have VBP cord-333672-ef53l283 49 18 proven prove VBN cord-333672-ef53l283 49 19 beneficial beneficial JJ cord-333672-ef53l283 49 20 , , , cord-333672-ef53l283 49 21 this this DT cord-333672-ef53l283 49 22 inconsistency inconsistency NN cord-333672-ef53l283 49 23 likely likely RB cord-333672-ef53l283 49 24 reflects reflect VBZ cord-333672-ef53l283 49 25 marked marked JJ cord-333672-ef53l283 49 26 heterogeneity heterogeneity NN cord-333672-ef53l283 49 27 in in IN cord-333672-ef53l283 49 28 the the DT cord-333672-ef53l283 49 29 methods method NNS cord-333672-ef53l283 49 30 used use VBN cord-333672-ef53l283 49 31 by by IN cord-333672-ef53l283 49 32 researchers researcher NNS cord-333672-ef53l283 49 33 ( ( -LRB- cord-333672-ef53l283 49 34 30 30 CD cord-333672-ef53l283 49 35 ) ) -RRB- cord-333672-ef53l283 49 36 , , , cord-333672-ef53l283 49 37 as as RB cord-333672-ef53l283 49 38 well well RB cord-333672-ef53l283 49 39 as as IN cord-333672-ef53l283 49 40 large large JJ cord-333672-ef53l283 49 41 variation variation NN cord-333672-ef53l283 49 42 between between IN cord-333672-ef53l283 49 43 people people NNS cord-333672-ef53l283 49 44 in in IN cord-333672-ef53l283 49 45 how how WRB cord-333672-ef53l283 49 46 they -PRON- PRP cord-333672-ef53l283 49 47 respond respond VBP cord-333672-ef53l283 49 48 to to IN cord-333672-ef53l283 49 49 light light NN cord-333672-ef53l283 49 50 ( ( -LRB- cord-333672-ef53l283 49 51 31 31 CD cord-333672-ef53l283 49 52 ) ) -RRB- cord-333672-ef53l283 49 53 . . . cord-333672-ef53l283 50 1 During during IN cord-333672-ef53l283 50 2 darkness darkness NN cord-333672-ef53l283 50 3 , , , cord-333672-ef53l283 50 4 retinal retinal JJ cord-333672-ef53l283 50 5 photoreceptors photoreceptor NNS cord-333672-ef53l283 50 6 no no RB cord-333672-ef53l283 50 7 longer longer RB cord-333672-ef53l283 50 8 register register VBP cord-333672-ef53l283 50 9 exposure exposure NN cord-333672-ef53l283 50 10 to to IN cord-333672-ef53l283 50 11 light light NN cord-333672-ef53l283 50 12 , , , cord-333672-ef53l283 50 13 relaying relay VBG cord-333672-ef53l283 50 14 this this DT cord-333672-ef53l283 50 15 to to IN cord-333672-ef53l283 50 16 the the DT cord-333672-ef53l283 50 17 central central JJ cord-333672-ef53l283 50 18 clock clock NN cord-333672-ef53l283 50 19 in in IN cord-333672-ef53l283 50 20 the the DT cord-333672-ef53l283 50 21 circadian circadian NN cord-333672-ef53l283 50 22 system system NN cord-333672-ef53l283 50 23 ( ( -LRB- cord-333672-ef53l283 50 24 the the DT cord-333672-ef53l283 50 25 suprachiasmatic suprachiasmatic JJ cord-333672-ef53l283 50 26 nucleus nucleus NN cord-333672-ef53l283 50 27 ) ) -RRB- cord-333672-ef53l283 50 28 , , , cord-333672-ef53l283 50 29 which which WDT cord-333672-ef53l283 50 30 in in IN cord-333672-ef53l283 50 31 turn turn NN cord-333672-ef53l283 50 32 signals signal VBZ cord-333672-ef53l283 50 33 the the DT cord-333672-ef53l283 50 34 pineal pineal NN cord-333672-ef53l283 50 35 gland gland NN cord-333672-ef53l283 50 36 to to TO cord-333672-ef53l283 50 37 synthesise synthesise VB cord-333672-ef53l283 50 38 melatonin melatonin NN cord-333672-ef53l283 50 39 . . . cord-333672-ef53l283 51 1 Melatonin melatonin NN cord-333672-ef53l283 51 2 therefore therefore RB cord-333672-ef53l283 51 3 acts act VBZ cord-333672-ef53l283 51 4 as as IN cord-333672-ef53l283 51 5 an an DT cord-333672-ef53l283 51 6 endogenous endogenous JJ cord-333672-ef53l283 51 7 marker marker NN cord-333672-ef53l283 51 8 of of IN cord-333672-ef53l283 51 9 darkness darkness NN cord-333672-ef53l283 51 10 , , , cord-333672-ef53l283 51 11 agonising agonise VBG cord-333672-ef53l283 51 12 its -PRON- PRP$ cord-333672-ef53l283 51 13 receptors receptor NNS cord-333672-ef53l283 51 14 in in IN cord-333672-ef53l283 51 15 cells cell NNS cord-333672-ef53l283 51 16 in in IN cord-333672-ef53l283 51 17 numerous numerous JJ cord-333672-ef53l283 51 18 tissues tissue NNS cord-333672-ef53l283 51 19 to to TO cord-333672-ef53l283 51 20 signal signal VB cord-333672-ef53l283 51 21 them -PRON- PRP cord-333672-ef53l283 51 22 to to TO cord-333672-ef53l283 51 23 fulfil fulfil VB cord-333672-ef53l283 51 24 time time NN cord-333672-ef53l283 51 25 - - HYPH cord-333672-ef53l283 51 26 ofday ofday NN cord-333672-ef53l283 51 27 - - HYPH cord-333672-ef53l283 51 28 specific specific JJ cord-333672-ef53l283 51 29 functions function NNS cord-333672-ef53l283 51 30 . . . cord-333672-ef53l283 52 1 Simplistically simplistically RB cord-333672-ef53l283 52 2 , , , cord-333672-ef53l283 52 3 when when WRB cord-333672-ef53l283 52 4 the the DT cord-333672-ef53l283 52 5 concentration concentration NN cord-333672-ef53l283 52 6 of of IN cord-333672-ef53l283 52 7 melatonin melatonin NN cord-333672-ef53l283 52 8 in in IN cord-333672-ef53l283 52 9 the the DT cord-333672-ef53l283 52 10 blood blood NN cord-333672-ef53l283 52 11 surpasses surpass VBZ cord-333672-ef53l283 52 12 a a DT cord-333672-ef53l283 52 13 certain certain JJ cord-333672-ef53l283 52 14 threshold threshold NN cord-333672-ef53l283 52 15 in in IN cord-333672-ef53l283 52 16 humans human NNS cord-333672-ef53l283 52 17 who who WP cord-333672-ef53l283 52 18 are be VBP cord-333672-ef53l283 52 19 melatonin melatonin NN cord-333672-ef53l283 52 20 - - HYPH cord-333672-ef53l283 52 21 proficient proficient JJ cord-333672-ef53l283 52 22 , , , cord-333672-ef53l283 52 23 it -PRON- PRP cord-333672-ef53l283 52 24 is be VBZ cord-333672-ef53l283 52 25 the the DT cord-333672-ef53l283 52 26 biological biological JJ cord-333672-ef53l283 52 27 night night NN cord-333672-ef53l283 52 28 - - HYPH cord-333672-ef53l283 52 29 time time NN cord-333672-ef53l283 52 30 . . . cord-333672-ef53l283 53 1 Conversely conversely RB cord-333672-ef53l283 53 2 , , , cord-333672-ef53l283 53 3 when when WRB cord-333672-ef53l283 53 4 the the DT cord-333672-ef53l283 53 5 concentration concentration NN cord-333672-ef53l283 53 6 of of IN cord-333672-ef53l283 53 7 melatonin melatonin NN cord-333672-ef53l283 53 8 is be VBZ cord-333672-ef53l283 53 9 below below IN cord-333672-ef53l283 53 10 this this DT cord-333672-ef53l283 53 11 threshold threshold NN cord-333672-ef53l283 53 12 , , , cord-333672-ef53l283 53 13 it -PRON- PRP cord-333672-ef53l283 53 14 is be VBZ cord-333672-ef53l283 53 15 the the DT cord-333672-ef53l283 53 16 biological biological JJ cord-333672-ef53l283 53 17 daytime daytime NN cord-333672-ef53l283 53 18 . . . cord-333672-ef53l283 54 1 Melatonin melatonin NN cord-333672-ef53l283 54 2 supplementation supplementation NN cord-333672-ef53l283 54 3 can can MD cord-333672-ef53l283 54 4 shift shift VB cord-333672-ef53l283 54 5 the the DT cord-333672-ef53l283 54 6 phase phase NN cord-333672-ef53l283 54 7 of of IN cord-333672-ef53l283 54 8 the the DT cord-333672-ef53l283 54 9 circadian circadian NN cord-333672-ef53l283 54 10 system system NN cord-333672-ef53l283 54 11 ( ( -LRB- cord-333672-ef53l283 54 12 32 32 CD cord-333672-ef53l283 54 13 ) ) -RRB- cord-333672-ef53l283 54 14 . . . cord-333672-ef53l283 55 1 Melatonin melatonin NN cord-333672-ef53l283 55 2 ingestion ingestion NN cord-333672-ef53l283 55 3 in in IN cord-333672-ef53l283 55 4 the the DT cord-333672-ef53l283 55 5 late late JJ cord-333672-ef53l283 55 6 biological biological JJ cord-333672-ef53l283 55 7 afternoon afternoon NN cord-333672-ef53l283 55 8 tends tend VBZ cord-333672-ef53l283 55 9 to to TO cord-333672-ef53l283 55 10 advance advance VB cord-333672-ef53l283 55 11 circadian circadian NN cord-333672-ef53l283 55 12 phase phase NN cord-333672-ef53l283 55 13 , , , cord-333672-ef53l283 55 14 while while IN cord-333672-ef53l283 55 15 ingestion ingestion NN cord-333672-ef53l283 55 16 in in IN cord-333672-ef53l283 55 17 the the DT cord-333672-ef53l283 55 18 early early JJ cord-333672-ef53l283 55 19 biological biological JJ cord-333672-ef53l283 55 20 morning morning NN cord-333672-ef53l283 55 21 tends tend VBZ cord-333672-ef53l283 55 22 to to TO cord-333672-ef53l283 55 23 delay delay VB cord-333672-ef53l283 55 24 it -PRON- PRP cord-333672-ef53l283 55 25 . . . cord-333672-ef53l283 56 1 Melatonin melatonin NN cord-333672-ef53l283 56 2 is be VBZ cord-333672-ef53l283 56 3 therefore therefore RB cord-333672-ef53l283 56 4 a a DT cord-333672-ef53l283 56 5 chronobiotic chronobiotic JJ cord-333672-ef53l283 56 6 -an -an CD cord-333672-ef53l283 56 7 agent agent NN cord-333672-ef53l283 56 8 that that WDT cord-333672-ef53l283 56 9 can can MD cord-333672-ef53l283 56 10 modify modify VB cord-333672-ef53l283 56 11 circadian circadian NN cord-333672-ef53l283 56 12 phase phase NN cord-333672-ef53l283 56 13 . . . cord-333672-ef53l283 57 1 When when WRB cord-333672-ef53l283 57 2 timed time VBN cord-333672-ef53l283 57 3 appropriately appropriately RB cord-333672-ef53l283 57 4 , , , cord-333672-ef53l283 57 5 light light JJ cord-333672-ef53l283 57 6 exposure exposure NN cord-333672-ef53l283 57 7 and and CC cord-333672-ef53l283 57 8 melatonin melatonin NN cord-333672-ef53l283 57 9 ingestion ingestion NN cord-333672-ef53l283 57 10 additively additively RB cord-333672-ef53l283 57 11 shift shift VBP cord-333672-ef53l283 57 12 circadian circadian NN cord-333672-ef53l283 57 13 phase phase NN cord-333672-ef53l283 57 14 ( ( -LRB- cord-333672-ef53l283 57 15 33 33 CD cord-333672-ef53l283 57 16 ) ) -RRB- cord-333672-ef53l283 57 17 . . . cord-333672-ef53l283 58 1 A a DT cord-333672-ef53l283 58 2 growing grow VBG cord-333672-ef53l283 58 3 body body NN cord-333672-ef53l283 58 4 of of IN cord-333672-ef53l283 58 5 evidence evidence NN cord-333672-ef53l283 58 6 also also RB cord-333672-ef53l283 58 7 shows show VBZ cord-333672-ef53l283 58 8 that that DT cord-333672-ef53l283 58 9 exercise exercise NN cord-333672-ef53l283 58 10 can can MD cord-333672-ef53l283 58 11 shift shift VB cord-333672-ef53l283 58 12 circadian circadian NN cord-333672-ef53l283 58 13 phase phase NN cord-333672-ef53l283 58 14 . . . cord-333672-ef53l283 59 1 Early early JJ cord-333672-ef53l283 59 2 research research NN cord-333672-ef53l283 59 3 demonstrated demonstrate VBD cord-333672-ef53l283 59 4 that that IN cord-333672-ef53l283 59 5 15 15 CD cord-333672-ef53l283 59 6 min min NN cord-333672-ef53l283 59 7 of of IN cord-333672-ef53l283 59 8 cycling cycling NN cord-333672-ef53l283 59 9 exercise exercise NN cord-333672-ef53l283 59 10 each each DT cord-333672-ef53l283 59 11 hour hour NN cord-333672-ef53l283 59 12 of of IN cord-333672-ef53l283 59 13 night night NN cord-333672-ef53l283 59 14 shifts shift NNS cord-333672-ef53l283 59 15 helped help VBD cord-333672-ef53l283 59 16 workers worker NNS cord-333672-ef53l283 59 17 adjust adjust VB cord-333672-ef53l283 59 18 their -PRON- PRP$ cord-333672-ef53l283 59 19 circadian circadian NN cord-333672-ef53l283 59 20 systems system NNS cord-333672-ef53l283 59 21 to to IN cord-333672-ef53l283 59 22 a a DT cord-333672-ef53l283 59 23 9-h 9-h CD cord-333672-ef53l283 59 24 delay delay NN cord-333672-ef53l283 59 25 in in IN cord-333672-ef53l283 59 26 bedtime bedtime NN cord-333672-ef53l283 59 27 ( ( -LRB- cord-333672-ef53l283 59 28 34 34 CD cord-333672-ef53l283 59 29 ) ) -RRB- cord-333672-ef53l283 59 30 . . . cord-333672-ef53l283 60 1 More More JJR cord-333672-ef53l283 60 2 recent recent JJ cord-333672-ef53l283 60 3 work work NN cord-333672-ef53l283 60 4 has have VBZ cord-333672-ef53l283 60 5 begun begin VBN cord-333672-ef53l283 60 6 to to TO cord-333672-ef53l283 60 7 clarify clarify VB cord-333672-ef53l283 60 8 the the DT cord-333672-ef53l283 60 9 precise precise JJ cord-333672-ef53l283 60 10 nature nature NN cord-333672-ef53l283 60 11 of of IN cord-333672-ef53l283 60 12 the the DT cord-333672-ef53l283 60 13 relationship relationship NN cord-333672-ef53l283 60 14 between between IN cord-333672-ef53l283 60 15 exercise exercise NN cord-333672-ef53l283 60 16 and and CC cord-333672-ef53l283 60 17 circadian circadian NN cord-333672-ef53l283 60 18 phase phase NN cord-333672-ef53l283 60 19 , , , cord-333672-ef53l283 60 20 showing show VBG cord-333672-ef53l283 60 21 that that IN cord-333672-ef53l283 60 22 treadmill treadmill NN cord-333672-ef53l283 60 23 exercise exercise NN cord-333672-ef53l283 60 24 done do VBN cord-333672-ef53l283 60 25 in in IN cord-333672-ef53l283 60 26 the the DT cord-333672-ef53l283 60 27 early early JJ cord-333672-ef53l283 60 28 biological biological JJ cord-333672-ef53l283 60 29 morning morning NN cord-333672-ef53l283 60 30 or or CC cord-333672-ef53l283 60 31 early early JJ cord-333672-ef53l283 60 32 biological biological JJ cord-333672-ef53l283 60 33 afternoon afternoon NN cord-333672-ef53l283 60 34 advances advance VBZ cord-333672-ef53l283 60 35 circadian circadian NN cord-333672-ef53l283 60 36 phase phase NN cord-333672-ef53l283 60 37 , , , cord-333672-ef53l283 60 38 whereas whereas IN cord-333672-ef53l283 60 39 the the DT cord-333672-ef53l283 60 40 same same JJ cord-333672-ef53l283 60 41 exercise exercise NN cord-333672-ef53l283 60 42 done do VBN cord-333672-ef53l283 60 43 in in IN cord-333672-ef53l283 60 44 the the DT cord-333672-ef53l283 60 45 biological biological JJ cord-333672-ef53l283 60 46 evening evening NN cord-333672-ef53l283 60 47 delays delay NNS cord-333672-ef53l283 60 48 it -PRON- PRP cord-333672-ef53l283 60 49 ( ( -LRB- cord-333672-ef53l283 60 50 35 35 CD cord-333672-ef53l283 60 51 ) ) -RRB- cord-333672-ef53l283 60 52 . . . cord-333672-ef53l283 61 1 This this DT cord-333672-ef53l283 61 2 relationship relationship NN cord-333672-ef53l283 61 3 is be VBZ cord-333672-ef53l283 61 4 therefore therefore RB cord-333672-ef53l283 61 5 similar similar JJ cord-333672-ef53l283 61 6 to to IN cord-333672-ef53l283 61 7 how how WRB cord-333672-ef53l283 61 8 timing timing NN cord-333672-ef53l283 61 9 of of IN cord-333672-ef53l283 61 10 exposure exposure NN cord-333672-ef53l283 61 11 to to IN cord-333672-ef53l283 61 12 light light JJ cord-333672-ef53l283 61 13 affects affect VBZ cord-333672-ef53l283 61 14 circadian circadian NN cord-333672-ef53l283 61 15 phase phase NN cord-333672-ef53l283 61 16 , , , cord-333672-ef53l283 61 17 and and CC cord-333672-ef53l283 61 18 timely timely JJ cord-333672-ef53l283 61 19 exposure exposure NN cord-333672-ef53l283 61 20 to to IN cord-333672-ef53l283 61 21 both both DT cord-333672-ef53l283 61 22 light light NN cord-333672-ef53l283 61 23 and and CC cord-333672-ef53l283 61 24 exercise exercise NN cord-333672-ef53l283 61 25 can can MD cord-333672-ef53l283 61 26 also also RB cord-333672-ef53l283 61 27 additively additively RB cord-333672-ef53l283 61 28 shift shift VB cord-333672-ef53l283 61 29 circadian circadian NN cord-333672-ef53l283 61 30 phase phase NN cord-333672-ef53l283 61 31 ( ( -LRB- cord-333672-ef53l283 61 32 36 36 CD cord-333672-ef53l283 61 33 ) ) -RRB- cord-333672-ef53l283 61 34 . . . cord-333672-ef53l283 62 1 The the DT cord-333672-ef53l283 62 2 influence influence NN cord-333672-ef53l283 62 3 of of IN cord-333672-ef53l283 62 4 timing timing NN cord-333672-ef53l283 62 5 of of IN cord-333672-ef53l283 62 6 food food NN cord-333672-ef53l283 62 7 availability availability NN cord-333672-ef53l283 62 8 on on IN cord-333672-ef53l283 62 9 patterns pattern NNS cord-333672-ef53l283 62 10 of of IN cord-333672-ef53l283 62 11 activity activity NN cord-333672-ef53l283 62 12 in in IN cord-333672-ef53l283 62 13 rats rat NNS cord-333672-ef53l283 62 14 was be VBD cord-333672-ef53l283 62 15 documented document VBN cord-333672-ef53l283 62 16 as as RB cord-333672-ef53l283 62 17 early early RB cord-333672-ef53l283 62 18 as as IN cord-333672-ef53l283 62 19 a a DT cord-333672-ef53l283 62 20 century century NN cord-333672-ef53l283 62 21 ago ago RB cord-333672-ef53l283 62 22 ( ( -LRB- cord-333672-ef53l283 62 23 37 37 CD cord-333672-ef53l283 62 24 ) ) -RRB- cord-333672-ef53l283 62 25 , , , cord-333672-ef53l283 62 26 and and CC cord-333672-ef53l283 62 27 numerous numerous JJ cord-333672-ef53l283 62 28 studies study NNS cord-333672-ef53l283 62 29 of of IN cord-333672-ef53l283 62 30 such such JJ cord-333672-ef53l283 62 31 " " `` cord-333672-ef53l283 62 32 food food NN cord-333672-ef53l283 62 33 anticipatory anticipatory NN cord-333672-ef53l283 62 34 activity activity NN cord-333672-ef53l283 62 35 " " '' cord-333672-ef53l283 62 36 have have VBP cord-333672-ef53l283 62 37 since since IN cord-333672-ef53l283 62 38 implicated implicate VBN cord-333672-ef53l283 62 39 nutrition nutrition NN cord-333672-ef53l283 62 40 as as IN cord-333672-ef53l283 62 41 an an DT cord-333672-ef53l283 62 42 influence influence NN cord-333672-ef53l283 62 43 on on IN cord-333672-ef53l283 62 44 circadian circadian NN cord-333672-ef53l283 62 45 system system NN cord-333672-ef53l283 62 46 timing timing NN cord-333672-ef53l283 62 47 . . . cord-333672-ef53l283 63 1 Whereas whereas IN cord-333672-ef53l283 63 2 the the DT cord-333672-ef53l283 63 3 LD LD NNP cord-333672-ef53l283 63 4 cycle cycle NN cord-333672-ef53l283 63 5 is be VBZ cord-333672-ef53l283 63 6 the the DT cord-333672-ef53l283 63 7 primary primary JJ cord-333672-ef53l283 63 8 zeitgeber zeitgeber NN cord-333672-ef53l283 63 9 for for IN cord-333672-ef53l283 63 10 the the DT cord-333672-ef53l283 63 11 suprachiasmatic suprachiasmatic JJ cord-333672-ef53l283 63 12 nucleus nucleus NN cord-333672-ef53l283 63 13 , , , cord-333672-ef53l283 63 14 some some DT cord-333672-ef53l283 63 15 scientists scientist NNS cord-333672-ef53l283 63 16 have have VBP cord-333672-ef53l283 63 17 hypothesised hypothesise VBN cord-333672-ef53l283 63 18 that that IN cord-333672-ef53l283 63 19 the the DT cord-333672-ef53l283 63 20 eating eat VBG cord-333672-ef53l283 63 21 / / SYM cord-333672-ef53l283 63 22 fasting fast VBG cord-333672-ef53l283 63 23 cycle cycle NN cord-333672-ef53l283 63 24 may may MD cord-333672-ef53l283 63 25 be be VB cord-333672-ef53l283 63 26 the the DT cord-333672-ef53l283 63 27 primary primary JJ cord-333672-ef53l283 63 28 time time NN cord-333672-ef53l283 63 29 cue cue NN cord-333672-ef53l283 63 30 for for IN cord-333672-ef53l283 63 31 some some DT cord-333672-ef53l283 63 32 peripheral peripheral JJ cord-333672-ef53l283 63 33 clocks clock NNS cord-333672-ef53l283 63 34 in in IN cord-333672-ef53l283 63 35 the the DT cord-333672-ef53l283 63 36 circadian circadian NN cord-333672-ef53l283 63 37 system system NN cord-333672-ef53l283 63 38 . . . cord-333672-ef53l283 64 1 We -PRON- PRP cord-333672-ef53l283 64 2 now now RB cord-333672-ef53l283 64 3 know know VBP cord-333672-ef53l283 64 4 that that IN cord-333672-ef53l283 64 5 changing change VBG cord-333672-ef53l283 64 6 the the DT cord-333672-ef53l283 64 7 timing timing NN cord-333672-ef53l283 64 8 of of IN cord-333672-ef53l283 64 9 food food NN cord-333672-ef53l283 64 10 consumption consumption NN cord-333672-ef53l283 64 11 rapidly rapidly RB cord-333672-ef53l283 64 12 alters alter VBZ cord-333672-ef53l283 64 13 the the DT cord-333672-ef53l283 64 14 timing timing NN cord-333672-ef53l283 64 15 of of IN cord-333672-ef53l283 64 16 gene gene NN cord-333672-ef53l283 64 17 transcription transcription NN cord-333672-ef53l283 64 18 in in IN cord-333672-ef53l283 64 19 peripheral peripheral JJ cord-333672-ef53l283 64 20 clocks clock NNS cord-333672-ef53l283 64 21 in in IN cord-333672-ef53l283 64 22 mice mouse NNS cord-333672-ef53l283 64 23 , , , cord-333672-ef53l283 64 24 for for IN cord-333672-ef53l283 64 25 example example NN cord-333672-ef53l283 64 26 ( ( -LRB- cord-333672-ef53l283 64 27 38 38 CD cord-333672-ef53l283 64 28 ) ) -RRB- cord-333672-ef53l283 64 29 . . . cord-333672-ef53l283 65 1 Recent recent JJ cord-333672-ef53l283 65 2 work work NN cord-333672-ef53l283 65 3 has have VBZ cord-333672-ef53l283 65 4 shown show VBN cord-333672-ef53l283 65 5 that that IN cord-333672-ef53l283 65 6 this this DT cord-333672-ef53l283 65 7 may may MD cord-333672-ef53l283 65 8 be be VB cord-333672-ef53l283 65 9 true true JJ cord-333672-ef53l283 65 10 of of IN cord-333672-ef53l283 65 11 humans human NNS cord-333672-ef53l283 65 12 too too RB cord-333672-ef53l283 65 13 , , , cord-333672-ef53l283 65 14 for for IN cord-333672-ef53l283 65 15 changing change VBG cord-333672-ef53l283 65 16 meal meal NN cord-333672-ef53l283 65 17 timing timing NN cord-333672-ef53l283 65 18 independently independently RB cord-333672-ef53l283 65 19 shifts shift VBZ cord-333672-ef53l283 65 20 the the DT cord-333672-ef53l283 65 21 expression expression NN cord-333672-ef53l283 65 22 of of IN cord-333672-ef53l283 65 23 some some DT cord-333672-ef53l283 65 24 genes gene NNS cord-333672-ef53l283 65 25 in in IN cord-333672-ef53l283 65 26 peripheral peripheral JJ cord-333672-ef53l283 65 27 tissues tissue NNS cord-333672-ef53l283 65 28 as as RB cord-333672-ef53l283 65 29 well well RB cord-333672-ef53l283 65 30 as as IN cord-333672-ef53l283 65 31 the the DT cord-333672-ef53l283 65 32 timing timing NN cord-333672-ef53l283 65 33 of of IN cord-333672-ef53l283 65 34 the the DT cord-333672-ef53l283 65 35 blood blood NN cord-333672-ef53l283 65 36 glucose glucose NN cord-333672-ef53l283 65 37 rhythm rhythm NN cord-333672-ef53l283 65 38 , , , cord-333672-ef53l283 65 39 without without IN cord-333672-ef53l283 65 40 changing change VBG cord-333672-ef53l283 65 41 the the DT cord-333672-ef53l283 65 42 phase phase NN cord-333672-ef53l283 65 43 of of IN cord-333672-ef53l283 65 44 the the DT cord-333672-ef53l283 65 45 melatonin melatonin NN cord-333672-ef53l283 65 46 rhythm rhythm NN cord-333672-ef53l283 65 47 ( ( -LRB- cord-333672-ef53l283 65 48 39 39 CD cord-333672-ef53l283 65 49 ) ) -RRB- cord-333672-ef53l283 65 50 . . . cord-333672-ef53l283 66 1 We -PRON- PRP cord-333672-ef53l283 66 2 acknowledge acknowledge VBP cord-333672-ef53l283 66 3 , , , cord-333672-ef53l283 66 4 however however RB cord-333672-ef53l283 66 5 , , , cord-333672-ef53l283 66 6 that that DT cord-333672-ef53l283 66 7 lack lack NN cord-333672-ef53l283 66 8 of of IN cord-333672-ef53l283 66 9 control control NN cord-333672-ef53l283 66 10 of of IN cord-333672-ef53l283 66 11 variables variable NNS cord-333672-ef53l283 66 12 such such JJ cord-333672-ef53l283 66 13 as as IN cord-333672-ef53l283 66 14 LD LD NNP cord-333672-ef53l283 66 15 cycles cycle NNS cord-333672-ef53l283 66 16 in in IN cord-333672-ef53l283 66 17 most most JJS cord-333672-ef53l283 66 18 studies study NNS cord-333672-ef53l283 66 19 of of IN cord-333672-ef53l283 66 20 the the DT cord-333672-ef53l283 66 21 effects effect NNS cord-333672-ef53l283 66 22 of of IN cord-333672-ef53l283 66 23 nutrition nutrition NN cord-333672-ef53l283 66 24 on on IN cord-333672-ef53l283 66 25 the the DT cord-333672-ef53l283 66 26 human human JJ cord-333672-ef53l283 66 27 circadian circadian NN cord-333672-ef53l283 66 28 system system NN cord-333672-ef53l283 66 29 mean mean VBP cord-333672-ef53l283 66 30 that that IN cord-333672-ef53l283 66 31 this this DT cord-333672-ef53l283 66 32 is be VBZ cord-333672-ef53l283 66 33 arguably arguably RB cord-333672-ef53l283 66 34 the the DT cord-333672-ef53l283 66 35 only only JJ cord-333672-ef53l283 66 36 study study NN cord-333672-ef53l283 66 37 of of IN cord-333672-ef53l283 66 38 people people NNS cord-333672-ef53l283 66 39 that that WDT cord-333672-ef53l283 66 40 fulfils fulfil VBZ cord-333672-ef53l283 66 41 at at IN cord-333672-ef53l283 66 42 least least RBS cord-333672-ef53l283 66 43 one one CD cord-333672-ef53l283 66 44 of of IN cord-333672-ef53l283 66 45 the the DT cord-333672-ef53l283 66 46 criteria criterion NNS cord-333672-ef53l283 66 47 for for IN cord-333672-ef53l283 66 48 diet diet NN cord-333672-ef53l283 66 49 to to TO cord-333672-ef53l283 66 50 be be VB cord-333672-ef53l283 66 51 classified classify VBN cord-333672-ef53l283 66 52 as as IN cord-333672-ef53l283 66 53 a a DT cord-333672-ef53l283 66 54 zeitgeber zeitgeber NN cord-333672-ef53l283 66 55 ( ( -LRB- cord-333672-ef53l283 66 56 40 40 CD cord-333672-ef53l283 66 57 ) ) -RRB- cord-333672-ef53l283 66 58 . . . cord-333672-ef53l283 67 1 It -PRON- PRP cord-333672-ef53l283 67 2 could could MD cord-333672-ef53l283 67 3 be be VB cord-333672-ef53l283 67 4 that that DT cord-333672-ef53l283 67 5 entrainment entrainment NN cord-333672-ef53l283 67 6 to to IN cord-333672-ef53l283 67 7 LD LD NNP cord-333672-ef53l283 67 8 cycles cycle NNS cord-333672-ef53l283 67 9 largely largely RB cord-333672-ef53l283 67 10 nullifies nullify VBZ cord-333672-ef53l283 67 11 any any DT cord-333672-ef53l283 67 12 zeitgeber zeitgeber NNP cord-333672-ef53l283 67 13 effects effect NNS cord-333672-ef53l283 67 14 of of IN cord-333672-ef53l283 67 15 nutrition nutrition NN cord-333672-ef53l283 67 16 ( ( -LRB- cord-333672-ef53l283 67 17 41 41 CD cord-333672-ef53l283 67 18 ) ) -RRB- cord-333672-ef53l283 67 19 . . . cord-333672-ef53l283 68 1 Summarising summarise VBG cord-333672-ef53l283 68 2 the the DT cord-333672-ef53l283 68 3 above above JJ cord-333672-ef53l283 68 4 , , , cord-333672-ef53l283 68 5 it -PRON- PRP cord-333672-ef53l283 68 6 is be VBZ cord-333672-ef53l283 68 7 plausible plausible JJ cord-333672-ef53l283 68 8 that that IN cord-333672-ef53l283 68 9 carefully carefully RB cord-333672-ef53l283 68 10 timed time VBD cord-333672-ef53l283 68 11 exposure exposure NN cord-333672-ef53l283 68 12 to to IN cord-333672-ef53l283 68 13 light light NN cord-333672-ef53l283 68 14 , , , cord-333672-ef53l283 68 15 melatonin melatonin NN cord-333672-ef53l283 68 16 ingestion ingestion NN cord-333672-ef53l283 68 17 , , , cord-333672-ef53l283 68 18 and and CC cord-333672-ef53l283 68 19 exercise exercise NN cord-333672-ef53l283 68 20 may may MD cord-333672-ef53l283 68 21 result result VB cord-333672-ef53l283 68 22 in in IN cord-333672-ef53l283 68 23 additive additive NN cord-333672-ef53l283 68 24 shifts shift NNS cord-333672-ef53l283 68 25 in in IN cord-333672-ef53l283 68 26 the the DT cord-333672-ef53l283 68 27 phase phase NN cord-333672-ef53l283 68 28 of of IN cord-333672-ef53l283 68 29 the the DT cord-333672-ef53l283 68 30 suprachiasmatic suprachiasmatic JJ cord-333672-ef53l283 68 31 nucleus nucleus NN cord-333672-ef53l283 68 32 . . . cord-333672-ef53l283 69 1 As as IN cord-333672-ef53l283 69 2 eating eat VBG cord-333672-ef53l283 69 3 / / SYM cord-333672-ef53l283 69 4 fasting fast VBG cord-333672-ef53l283 69 5 cycles cycle NNS cord-333672-ef53l283 69 6 appear appear VBP cord-333672-ef53l283 69 7 to to TO cord-333672-ef53l283 69 8 affect affect VB cord-333672-ef53l283 69 9 the the DT cord-333672-ef53l283 69 10 phases phase NNS cord-333672-ef53l283 69 11 of of IN cord-333672-ef53l283 69 12 some some DT cord-333672-ef53l283 69 13 peripheral peripheral JJ cord-333672-ef53l283 69 14 circadian circadian NN cord-333672-ef53l283 69 15 clocks clock NNS cord-333672-ef53l283 69 16 , , , cord-333672-ef53l283 69 17 we -PRON- PRP cord-333672-ef53l283 69 18 anticipate anticipate VBP cord-333672-ef53l283 69 19 that that IN cord-333672-ef53l283 69 20 coordinated coordinate VBN cord-333672-ef53l283 69 21 changes change NNS cord-333672-ef53l283 69 22 in in IN cord-333672-ef53l283 69 23 all all DT cord-333672-ef53l283 69 24 of of IN cord-333672-ef53l283 69 25 these these DT cord-333672-ef53l283 69 26 variables variable NNS cord-333672-ef53l283 69 27 could could MD cord-333672-ef53l283 69 28 be be VB cord-333672-ef53l283 69 29 used use VBN cord-333672-ef53l283 69 30 to to TO cord-333672-ef53l283 69 31 expedite expedite VB cord-333672-ef53l283 69 32 adaptation adaptation NN cord-333672-ef53l283 69 33 to to IN cord-333672-ef53l283 69 34 new new JJ cord-333672-ef53l283 69 35 shift shift NN cord-333672-ef53l283 69 36 work work NN cord-333672-ef53l283 69 37 schedules schedule NNS cord-333672-ef53l283 69 38 . . . cord-333672-ef53l283 70 1 If if IN cord-333672-ef53l283 70 2 one one PRP cord-333672-ef53l283 70 3 could could MD cord-333672-ef53l283 70 4 estimate estimate VB cord-333672-ef53l283 70 5 shift shift VB cord-333672-ef53l283 70 6 workers worker NNS cord-333672-ef53l283 70 7 ' ' POS cord-333672-ef53l283 70 8 circadian circadian NN cord-333672-ef53l283 70 9 phases phase NNS cord-333672-ef53l283 70 10 in in IN cord-333672-ef53l283 70 11 real real JJ cord-333672-ef53l283 70 12 time time NN cord-333672-ef53l283 70 13 and and CC cord-333672-ef53l283 70 14 model model VB cord-333672-ef53l283 70 15 how how WRB cord-333672-ef53l283 70 16 subsequent subsequent JJ cord-333672-ef53l283 70 17 changes change NNS cord-333672-ef53l283 70 18 in in IN cord-333672-ef53l283 70 19 zeitgeber zeitgeber NNP cord-333672-ef53l283 70 20 schedules schedule NNS cord-333672-ef53l283 70 21 would would MD cord-333672-ef53l283 70 22 influence influence VB cord-333672-ef53l283 70 23 their -PRON- PRP$ cord-333672-ef53l283 70 24 circadian circadian NN cord-333672-ef53l283 70 25 systems system NNS cord-333672-ef53l283 70 26 , , , cord-333672-ef53l283 70 27 one one PRP cord-333672-ef53l283 70 28 could could MD cord-333672-ef53l283 70 29 develop develop VB cord-333672-ef53l283 70 30 tools tool NNS cord-333672-ef53l283 70 31 that that WDT cord-333672-ef53l283 70 32 use use VBP cord-333672-ef53l283 70 33 this this DT cord-333672-ef53l283 70 34 information information NN cord-333672-ef53l283 70 35 to to TO cord-333672-ef53l283 70 36 expedite expedite VB cord-333672-ef53l283 70 37 adaptation adaptation NN cord-333672-ef53l283 70 38 to to TO cord-333672-ef53l283 70 39 shift shift VB cord-333672-ef53l283 70 40 schedule schedule NN cord-333672-ef53l283 70 41 changes change NNS cord-333672-ef53l283 70 42 by by IN cord-333672-ef53l283 70 43 providing provide VBG cord-333672-ef53l283 70 44 personalised personalised JJ cord-333672-ef53l283 70 45 guidance guidance NN cord-333672-ef53l283 70 46 and and CC cord-333672-ef53l283 70 47 perhaps perhaps RB cord-333672-ef53l283 70 48 even even RB cord-333672-ef53l283 70 49 individual individual JJ cord-333672-ef53l283 70 50 - - HYPH cord-333672-ef53l283 70 51 level level NN cord-333672-ef53l283 70 52 changes change NNS cord-333672-ef53l283 70 53 in in IN cord-333672-ef53l283 70 54 exposure exposure NN cord-333672-ef53l283 70 55 to to IN cord-333672-ef53l283 70 56 light light NN cord-333672-ef53l283 70 57 . . . cord-333672-ef53l283 71 1 This this DT cord-333672-ef53l283 71 2 may may MD cord-333672-ef53l283 71 3 be be VB cord-333672-ef53l283 71 4 a a DT cord-333672-ef53l283 71 5 particularly particularly RB cord-333672-ef53l283 71 6 fruitful fruitful JJ cord-333672-ef53l283 71 7 topic topic NN cord-333672-ef53l283 71 8 for for IN cord-333672-ef53l283 71 9 further further JJ cord-333672-ef53l283 71 10 study study NN cord-333672-ef53l283 71 11 . . . cord-333672-ef53l283 72 1 While while IN cord-333672-ef53l283 72 2 it -PRON- PRP cord-333672-ef53l283 72 3 is be VBZ cord-333672-ef53l283 72 4 plausible plausible JJ cord-333672-ef53l283 72 5 that that IN cord-333672-ef53l283 72 6 one one PRP cord-333672-ef53l283 72 7 could could MD cord-333672-ef53l283 72 8 change change VB cord-333672-ef53l283 72 9 nutrient nutrient NN cord-333672-ef53l283 72 10 timing timing NN cord-333672-ef53l283 72 11 to to TO cord-333672-ef53l283 72 12 accelerate accelerate VB cord-333672-ef53l283 72 13 adaptation adaptation NN cord-333672-ef53l283 72 14 to to IN cord-333672-ef53l283 72 15 new new JJ cord-333672-ef53l283 72 16 shift shift NN cord-333672-ef53l283 72 17 work work NN cord-333672-ef53l283 72 18 schedules schedule NNS cord-333672-ef53l283 72 19 , , , cord-333672-ef53l283 72 20 in in IN cord-333672-ef53l283 72 21 many many JJ cord-333672-ef53l283 72 22 instances instance NNS cord-333672-ef53l283 72 23 shift shift VBP cord-333672-ef53l283 72 24 workers worker NNS cord-333672-ef53l283 72 25 do do VBP cord-333672-ef53l283 72 26 not not RB cord-333672-ef53l283 72 27 seek seek VB cord-333672-ef53l283 72 28 to to TO cord-333672-ef53l283 72 29 fully fully RB cord-333672-ef53l283 72 30 adjust adjust VB cord-333672-ef53l283 72 31 to to IN cord-333672-ef53l283 72 32 their -PRON- PRP$ cord-333672-ef53l283 72 33 new new JJ cord-333672-ef53l283 72 34 shifts shift NNS cord-333672-ef53l283 72 35 . . . cord-333672-ef53l283 73 1 This this DT cord-333672-ef53l283 73 2 raises raise VBZ cord-333672-ef53l283 73 3 the the DT cord-333672-ef53l283 73 4 question question NN cord-333672-ef53l283 73 5 of of IN cord-333672-ef53l283 73 6 whether whether IN cord-333672-ef53l283 73 7 workers worker NNS cord-333672-ef53l283 73 8 undergoing undergo VBG cord-333672-ef53l283 73 9 transient transient JJ cord-333672-ef53l283 73 10 changes change NNS cord-333672-ef53l283 73 11 in in IN cord-333672-ef53l283 73 12 work work NN cord-333672-ef53l283 73 13 schedules schedule NNS cord-333672-ef53l283 73 14 should should MD cord-333672-ef53l283 73 15 adjust adjust VB cord-333672-ef53l283 73 16 their -PRON- PRP$ cord-333672-ef53l283 73 17 diets diet NNS cord-333672-ef53l283 73 18 accordingly accordingly RB cord-333672-ef53l283 73 19 . . . cord-333672-ef53l283 74 1 However however RB cord-333672-ef53l283 74 2 , , , cord-333672-ef53l283 74 3 it -PRON- PRP cord-333672-ef53l283 74 4 is be VBZ cord-333672-ef53l283 74 5 also also RB cord-333672-ef53l283 74 6 crucial crucial JJ cord-333672-ef53l283 74 7 to to TO cord-333672-ef53l283 74 8 consider consider VB cord-333672-ef53l283 74 9 contextual contextual JJ cord-333672-ef53l283 74 10 factors factor NNS cord-333672-ef53l283 74 11 that that WDT cord-333672-ef53l283 74 12 influence influence VBP cord-333672-ef53l283 74 13 when when WRB cord-333672-ef53l283 74 14 shift shift NN cord-333672-ef53l283 74 15 workers worker NNS cord-333672-ef53l283 74 16 eat eat VBP cord-333672-ef53l283 74 17 and and CC cord-333672-ef53l283 74 18 drink drink VBP cord-333672-ef53l283 74 19 . . . cord-333672-ef53l283 75 1 Work work NN cord-333672-ef53l283 75 2 schedules schedule NNS cord-333672-ef53l283 75 3 , , , cord-333672-ef53l283 75 4 time time NN cord-333672-ef53l283 75 5 constraints constraint NNS cord-333672-ef53l283 75 6 , , , cord-333672-ef53l283 75 7 timing timing NN cord-333672-ef53l283 75 8 of of IN cord-333672-ef53l283 75 9 breaks break NNS cord-333672-ef53l283 75 10 within within IN cord-333672-ef53l283 75 11 shifts shift NNS cord-333672-ef53l283 75 12 , , , cord-333672-ef53l283 75 13 family family NN cord-333672-ef53l283 75 14 commitments commitment NNS cord-333672-ef53l283 75 15 , , , cord-333672-ef53l283 75 16 and and CC cord-333672-ef53l283 75 17 prioritising prioritise VBG cord-333672-ef53l283 75 18 behaviours behaviour NNS cord-333672-ef53l283 75 19 such such JJ cord-333672-ef53l283 75 20 as as IN cord-333672-ef53l283 75 21 sleep sleep NN cord-333672-ef53l283 75 22 over over IN cord-333672-ef53l283 75 23 meals meal NNS cord-333672-ef53l283 75 24 all all DT cord-333672-ef53l283 75 25 influence influence VBP cord-333672-ef53l283 75 26 diet diet NN cord-333672-ef53l283 75 27 timing timing NN cord-333672-ef53l283 75 28 in in IN cord-333672-ef53l283 75 29 shift shift NN cord-333672-ef53l283 75 30 workers worker NNS cord-333672-ef53l283 75 31 , , , cord-333672-ef53l283 75 32 leading lead VBG cord-333672-ef53l283 75 33 to to IN cord-333672-ef53l283 75 34 erratic erratic JJ cord-333672-ef53l283 75 35 diet diet NN cord-333672-ef53l283 75 36 timing timing NN cord-333672-ef53l283 75 37 patterns pattern NNS cord-333672-ef53l283 75 38 in in IN cord-333672-ef53l283 75 39 these these DT cord-333672-ef53l283 75 40 people people NNS cord-333672-ef53l283 75 41 ( ( -LRB- cord-333672-ef53l283 75 42 42 42 CD cord-333672-ef53l283 75 43 ) ) -RRB- cord-333672-ef53l283 75 44 . . . cord-333672-ef53l283 76 1 Diet diet NN cord-333672-ef53l283 76 2 timing timing NN cord-333672-ef53l283 76 3 irregularities irregularity NNS cord-333672-ef53l283 76 4 are be VBP cord-333672-ef53l283 76 5 also also RB cord-333672-ef53l283 76 6 affected affect VBN cord-333672-ef53l283 76 7 by by IN cord-333672-ef53l283 76 8 cultural cultural JJ cord-333672-ef53l283 76 9 factors factor NNS cord-333672-ef53l283 76 10 ( ( -LRB- cord-333672-ef53l283 76 11 e.g. e.g. RB cord-333672-ef53l283 76 12 , , , cord-333672-ef53l283 76 13 Ramadan Ramadan NNP cord-333672-ef53l283 76 14 ) ) -RRB- cord-333672-ef53l283 76 15 and and CC cord-333672-ef53l283 76 16 the the DT cord-333672-ef53l283 76 17 nature nature NN cord-333672-ef53l283 76 18 of of IN cord-333672-ef53l283 76 19 some some DT cord-333672-ef53l283 76 20 jobs job NNS cord-333672-ef53l283 76 21 ( ( -LRB- cord-333672-ef53l283 76 22 e.g. e.g. RB cord-333672-ef53l283 76 23 , , , cord-333672-ef53l283 76 24 many many JJ cord-333672-ef53l283 76 25 on on IN cord-333672-ef53l283 76 26 - - HYPH cord-333672-ef53l283 76 27 call call NN cord-333672-ef53l283 76 28 workers worker NNS cord-333672-ef53l283 76 29 have have VBP cord-333672-ef53l283 76 30 especially especially RB cord-333672-ef53l283 76 31 unpredictable unpredictable JJ cord-333672-ef53l283 76 32 work work NN cord-333672-ef53l283 76 33 schedules schedule NNS cord-333672-ef53l283 76 34 ) ) -RRB- cord-333672-ef53l283 76 35 . . . cord-333672-ef53l283 77 1 Temporarily temporarily RB cord-333672-ef53l283 77 2 putting put VBG cord-333672-ef53l283 77 3 these these DT cord-333672-ef53l283 77 4 complexities complexity NNS cord-333672-ef53l283 77 5 to to IN cord-333672-ef53l283 77 6 one one CD cord-333672-ef53l283 77 7 side side NN cord-333672-ef53l283 77 8 , , , cord-333672-ef53l283 77 9 controlled control VBN cord-333672-ef53l283 77 10 experiments experiment NNS cord-333672-ef53l283 77 11 have have VBP cord-333672-ef53l283 77 12 begun begin VBN cord-333672-ef53l283 77 13 to to TO cord-333672-ef53l283 77 14 explore explore VB cord-333672-ef53l283 77 15 the the DT cord-333672-ef53l283 77 16 effects effect NNS cord-333672-ef53l283 77 17 of of IN cord-333672-ef53l283 77 18 diet diet NN cord-333672-ef53l283 77 19 timing timing NN cord-333672-ef53l283 77 20 during during IN cord-333672-ef53l283 77 21 pre pre JJ cord-333672-ef53l283 77 22 - - JJ cord-333672-ef53l283 77 23 clinical clinical JJ cord-333672-ef53l283 77 24 and and CC cord-333672-ef53l283 77 25 clinical clinical JJ cord-333672-ef53l283 77 26 simulations simulation NNS cord-333672-ef53l283 77 27 of of IN cord-333672-ef53l283 77 28 shift shift NN cord-333672-ef53l283 77 29 work work NN cord-333672-ef53l283 77 30 . . . cord-333672-ef53l283 78 1 Table table NN cord-333672-ef53l283 78 2 1 1 CD cord-333672-ef53l283 78 3 summarises summarise VBZ cord-333672-ef53l283 78 4 our -PRON- PRP$ cord-333672-ef53l283 78 5 dietary dietary JJ cord-333672-ef53l283 78 6 and and CC cord-333672-ef53l283 78 7 supplementation supplementation NN cord-333672-ef53l283 78 8 suggestions suggestion NNS cord-333672-ef53l283 78 9 for for IN cord-333672-ef53l283 78 10 shift shift NN cord-333672-ef53l283 78 11 workers worker NNS cord-333672-ef53l283 78 12 based base VBN cord-333672-ef53l283 78 13 on on IN cord-333672-ef53l283 78 14 our -PRON- PRP$ cord-333672-ef53l283 78 15 interpretation interpretation NN cord-333672-ef53l283 78 16 of of IN cord-333672-ef53l283 78 17 the the DT cord-333672-ef53l283 78 18 current current JJ cord-333672-ef53l283 78 19 literature literature NN cord-333672-ef53l283 78 20 . . . cord-333672-ef53l283 79 1 Beginning begin VBG cord-333672-ef53l283 79 2 with with IN cord-333672-ef53l283 79 3 preclinical preclinical JJ cord-333672-ef53l283 79 4 research research NN cord-333672-ef53l283 79 5 , , , cord-333672-ef53l283 79 6 studies study NNS cord-333672-ef53l283 79 7 of of IN cord-333672-ef53l283 79 8 mice mouse NNS cord-333672-ef53l283 79 9 have have VBP cord-333672-ef53l283 79 10 shown show VBN cord-333672-ef53l283 79 11 that that IN cord-333672-ef53l283 79 12 restricting restrict VBG cord-333672-ef53l283 79 13 food food NN cord-333672-ef53l283 79 14 access access NN cord-333672-ef53l283 79 15 to to IN cord-333672-ef53l283 79 16 the the DT cord-333672-ef53l283 79 17 dark dark JJ cord-333672-ef53l283 79 18 period period NN cord-333672-ef53l283 79 19 ( ( -LRB- cord-333672-ef53l283 79 20 the the DT cord-333672-ef53l283 79 21 active active JJ cord-333672-ef53l283 79 22 phase phase NN cord-333672-ef53l283 79 23 for for IN cord-333672-ef53l283 79 24 these these DT cord-333672-ef53l283 79 25 nocturnal nocturnal JJ cord-333672-ef53l283 79 26 animals animal NNS cord-333672-ef53l283 79 27 ) ) -RRB- cord-333672-ef53l283 79 28 may may MD cord-333672-ef53l283 79 29 protect protect VB cord-333672-ef53l283 79 30 against against IN cord-333672-ef53l283 79 31 the the DT cord-333672-ef53l283 79 32 obesogenic obesogenic JJ cord-333672-ef53l283 79 33 effects effect NNS cord-333672-ef53l283 79 34 of of IN cord-333672-ef53l283 79 35 repeated repeat VBN cord-333672-ef53l283 79 36 6-h 6-h CD cord-333672-ef53l283 79 37 advances advance NNS cord-333672-ef53l283 79 38 in in IN cord-333672-ef53l283 79 39 the the DT cord-333672-ef53l283 79 40 LD LD NNP cord-333672-ef53l283 79 41 cycle cycle NN cord-333672-ef53l283 79 42 ( ( -LRB- cord-333672-ef53l283 79 43 48 48 CD cord-333672-ef53l283 79 44 ) ) -RRB- cord-333672-ef53l283 79 45 . . . cord-333672-ef53l283 80 1 In in IN cord-333672-ef53l283 80 2 addition addition NN cord-333672-ef53l283 80 3 , , , cord-333672-ef53l283 80 4 restricting restrict VBG cord-333672-ef53l283 80 5 food food NN cord-333672-ef53l283 80 6 access access NN cord-333672-ef53l283 80 7 to to IN cord-333672-ef53l283 80 8 the the DT cord-333672-ef53l283 80 9 active active JJ cord-333672-ef53l283 80 10 phase phase NN cord-333672-ef53l283 80 11 may may MD cord-333672-ef53l283 80 12 also also RB cord-333672-ef53l283 80 13 accelerate accelerate VB cord-333672-ef53l283 80 14 adaptation adaptation NN cord-333672-ef53l283 80 15 of of IN cord-333672-ef53l283 80 16 circadian circadian NN cord-333672-ef53l283 80 17 rhythms rhythm NNS cord-333672-ef53l283 80 18 in in IN cord-333672-ef53l283 80 19 core core NN cord-333672-ef53l283 80 20 body body NN cord-333672-ef53l283 80 21 temperature temperature NN cord-333672-ef53l283 80 22 and and CC cord-333672-ef53l283 80 23 locomotor locomotor NN cord-333672-ef53l283 80 24 activity activity NN cord-333672-ef53l283 80 25 to to IN cord-333672-ef53l283 80 26 repeated repeat VBD cord-333672-ef53l283 80 27 12-h 12-h JJ cord-333672-ef53l283 80 28 changes change NNS cord-333672-ef53l283 80 29 in in IN cord-333672-ef53l283 80 30 LD LD NNP cord-333672-ef53l283 80 31 cycles cycle NNS cord-333672-ef53l283 80 32 ( ( -LRB- cord-333672-ef53l283 80 33 49 49 CD cord-333672-ef53l283 80 34 ) ) -RRB- cord-333672-ef53l283 80 35 . . . cord-333672-ef53l283 81 1 These these DT cord-333672-ef53l283 81 2 findings finding NNS cord-333672-ef53l283 81 3 imply imply VBP cord-333672-ef53l283 81 4 that that IN cord-333672-ef53l283 81 5 people people NNS cord-333672-ef53l283 81 6 would would MD cord-333672-ef53l283 81 7 better better RB cord-333672-ef53l283 81 8 cope cope VB cord-333672-ef53l283 81 9 with with IN cord-333672-ef53l283 81 10 rotating rotate VBG cord-333672-ef53l283 81 11 shift shift NN cord-333672-ef53l283 81 12 work work NN cord-333672-ef53l283 81 13 if if IN cord-333672-ef53l283 81 14 they -PRON- PRP cord-333672-ef53l283 81 15 fixed fix VBD cord-333672-ef53l283 81 16 their -PRON- PRP$ cord-333672-ef53l283 81 17 eating eating NN cord-333672-ef53l283 81 18 to to IN cord-333672-ef53l283 81 19 the the DT cord-333672-ef53l283 81 20 daytime daytime NN cord-333672-ef53l283 81 21 , , , cord-333672-ef53l283 81 22 which which WDT cord-333672-ef53l283 81 23 is be VBZ cord-333672-ef53l283 81 24 somewhat somewhat RB cord-333672-ef53l283 81 25 counterintuitive counterintuitive JJ cord-333672-ef53l283 81 26 given give VBN cord-333672-ef53l283 81 27 that that IN cord-333672-ef53l283 81 28 fixing fix VBG cord-333672-ef53l283 81 29 eating eat VBG cord-333672-ef53l283 81 30 time time NN cord-333672-ef53l283 81 31 during during IN cord-333672-ef53l283 81 32 shifting shift VBG cord-333672-ef53l283 81 33 LD LD NNP cord-333672-ef53l283 81 34 cycles cycle NNS cord-333672-ef53l283 81 35 might may MD cord-333672-ef53l283 81 36 be be VB cord-333672-ef53l283 81 37 expected expect VBN cord-333672-ef53l283 81 38 to to TO cord-333672-ef53l283 81 39 uncouple uncouple VB cord-333672-ef53l283 81 40 circadian circadian NN cord-333672-ef53l283 81 41 rhythms rhythm NNS cord-333672-ef53l283 81 42 between between IN cord-333672-ef53l283 81 43 the the DT cord-333672-ef53l283 81 44 suprachiasmatic suprachiasmatic JJ cord-333672-ef53l283 81 45 nucleus nucleus NN cord-333672-ef53l283 81 46 and and CC cord-333672-ef53l283 81 47 peripheral peripheral JJ cord-333672-ef53l283 81 48 clocks clock NNS cord-333672-ef53l283 81 49 . . . cord-333672-ef53l283 82 1 It -PRON- PRP cord-333672-ef53l283 82 2 is be VBZ cord-333672-ef53l283 82 3 , , , cord-333672-ef53l283 82 4 however however RB cord-333672-ef53l283 82 5 , , , cord-333672-ef53l283 82 6 intuitive intuitive JJ cord-333672-ef53l283 82 7 that that IN cord-333672-ef53l283 82 8 restricting restrict VBG cord-333672-ef53l283 82 9 food food NN cord-333672-ef53l283 82 10 access access NN cord-333672-ef53l283 82 11 to to IN cord-333672-ef53l283 82 12 the the DT cord-333672-ef53l283 82 13 active active JJ cord-333672-ef53l283 82 14 phase phase NN cord-333672-ef53l283 82 15 may may MD cord-333672-ef53l283 82 16 be be VB cord-333672-ef53l283 82 17 preferable preferable JJ cord-333672-ef53l283 82 18 to to IN cord-333672-ef53l283 82 19 restricting restrict VBG cord-333672-ef53l283 82 20 it -PRON- PRP cord-333672-ef53l283 82 21 to to IN cord-333672-ef53l283 82 22 the the DT cord-333672-ef53l283 82 23 rest rest NN cord-333672-ef53l283 82 24 phase phase NN cord-333672-ef53l283 82 25 , , , cord-333672-ef53l283 82 26 and and CC cord-333672-ef53l283 82 27 findings finding NNS cord-333672-ef53l283 82 28 from from IN cord-333672-ef53l283 82 29 initial initial JJ cord-333672-ef53l283 82 30 research research NN cord-333672-ef53l283 82 31 on on IN cord-333672-ef53l283 82 32 humans human NNS cord-333672-ef53l283 82 33 support support VBP cord-333672-ef53l283 82 34 this this DT cord-333672-ef53l283 82 35 contention contention NN cord-333672-ef53l283 82 36 . . . cord-333672-ef53l283 83 1 Among among IN cord-333672-ef53l283 83 2 healthy healthy JJ cord-333672-ef53l283 83 3 young young JJ cord-333672-ef53l283 83 4 men man NNS cord-333672-ef53l283 83 5 undergoing undergo VBG cord-333672-ef53l283 83 6 simulated simulated JJ cord-333672-ef53l283 83 7 night night NN cord-333672-ef53l283 83 8 shift shift NN cord-333672-ef53l283 83 9 work work NN cord-333672-ef53l283 83 10 for for IN cord-333672-ef53l283 83 11 4 4 CD cord-333672-ef53l283 83 12 days day NNS cord-333672-ef53l283 83 13 , , , cord-333672-ef53l283 83 14 those those DT cord-333672-ef53l283 83 15 who who WP cord-333672-ef53l283 83 16 confined confine VBD cord-333672-ef53l283 83 17 their -PRON- PRP$ cord-333672-ef53l283 83 18 consumption consumption NN cord-333672-ef53l283 83 19 of of IN cord-333672-ef53l283 83 20 calorie calorie NN cord-333672-ef53l283 83 21 - - HYPH cord-333672-ef53l283 83 22 containing contain VBG cord-333672-ef53l283 83 23 foods food NNS cord-333672-ef53l283 83 24 and and CC cord-333672-ef53l283 83 25 drinks drink NNS cord-333672-ef53l283 83 26 ( ( -LRB- cord-333672-ef53l283 83 27 i.e. i.e. FW cord-333672-ef53l283 83 28 , , , cord-333672-ef53l283 83 29 the the DT cord-333672-ef53l283 83 30 caloric caloric JJ cord-333672-ef53l283 83 31 period period NN cord-333672-ef53l283 83 32 ) ) -RRB- cord-333672-ef53l283 83 33 to to IN cord-333672-ef53l283 83 34 between between IN cord-333672-ef53l283 83 35 breakfast breakfast NN cord-333672-ef53l283 83 36 at at IN cord-333672-ef53l283 83 37 07:00 07:00 CD cord-333672-ef53l283 83 38 and and CC cord-333672-ef53l283 83 39 dinner dinner NN cord-333672-ef53l283 83 40 at at IN cord-333672-ef53l283 83 41 19:00 19:00 CD cord-333672-ef53l283 83 42 had have VBD cord-333672-ef53l283 83 43 superior superior JJ cord-333672-ef53l283 83 44 postbreakfast postbreakfast NN cord-333672-ef53l283 83 45 glucose glucose NN cord-333672-ef53l283 83 46 tolerance tolerance NN cord-333672-ef53l283 83 47 after after IN cord-333672-ef53l283 83 48 the the DT cord-333672-ef53l283 83 49 intervention intervention NN cord-333672-ef53l283 83 50 compared compare VBN cord-333672-ef53l283 83 51 to to IN cord-333672-ef53l283 83 52 men man NNS cord-333672-ef53l283 83 53 who who WP cord-333672-ef53l283 83 54 had have VBD cord-333672-ef53l283 83 55 dinner dinner NN cord-333672-ef53l283 83 56 at at IN cord-333672-ef53l283 83 57 19:00 19:00 CD cord-333672-ef53l283 83 58 , , , cord-333672-ef53l283 83 59 a a DT cord-333672-ef53l283 83 60 meal meal NN cord-333672-ef53l283 83 61 at at IN cord-333672-ef53l283 83 62 01:30 01:30 CD cord-333672-ef53l283 83 63 , , , cord-333672-ef53l283 83 64 and and CC cord-333672-ef53l283 83 65 breakfast breakfast NN cord-333672-ef53l283 83 66 at at IN cord-333672-ef53l283 83 67 07:00 07:00 CD cord-333672-ef53l283 83 68 ( ( -LRB- cord-333672-ef53l283 83 69 50 50 CD cord-333672-ef53l283 83 70 ) ) -RRB- cord-333672-ef53l283 83 71 . . . cord-333672-ef53l283 84 1 The the DT cord-333672-ef53l283 84 2 group group NN cord-333672-ef53l283 84 3 that that WDT cord-333672-ef53l283 84 4 restricted restrict VBD cord-333672-ef53l283 84 5 food food NN cord-333672-ef53l283 84 6 intake intake NN cord-333672-ef53l283 84 7 to to IN cord-333672-ef53l283 84 8 the the DT cord-333672-ef53l283 84 9 daytime daytime NN cord-333672-ef53l283 84 10 also also RB cord-333672-ef53l283 84 11 had have VBD cord-333672-ef53l283 84 12 superior superior JJ cord-333672-ef53l283 84 13 overnight overnight JJ cord-333672-ef53l283 84 14 cognitive cognitive JJ cord-333672-ef53l283 84 15 function function NN cord-333672-ef53l283 84 16 ( ( -LRB- cord-333672-ef53l283 84 17 51 51 CD cord-333672-ef53l283 84 18 ) ) -RRB- cord-333672-ef53l283 84 19 . . . cord-333672-ef53l283 85 1 This this DT cord-333672-ef53l283 85 2 is be VBZ cord-333672-ef53l283 85 3 especially especially RB cord-333672-ef53l283 85 4 salient salient JJ cord-333672-ef53l283 85 5 given give VBN cord-333672-ef53l283 85 6 that that IN cord-333672-ef53l283 85 7 many many JJ cord-333672-ef53l283 85 8 shift shift NN cord-333672-ef53l283 85 9 workers worker NNS cord-333672-ef53l283 85 10 redistribute redistribute VBP cord-333672-ef53l283 85 11 their -PRON- PRP$ cord-333672-ef53l283 85 12 energy energy NN cord-333672-ef53l283 85 13 intakes intake NNS cord-333672-ef53l283 85 14 into into IN cord-333672-ef53l283 85 15 the the DT cord-333672-ef53l283 85 16 night night NN cord-333672-ef53l283 85 17 when when WRB cord-333672-ef53l283 85 18 working working NN cord-333672-ef53l283 85 19 shifts shift NNS cord-333672-ef53l283 85 20 ( ( -LRB- cord-333672-ef53l283 85 21 52 52 CD cord-333672-ef53l283 85 22 ) ) -RRB- cord-333672-ef53l283 85 23 . . . cord-333672-ef53l283 86 1 Additional additional JJ cord-333672-ef53l283 86 2 studies study NNS cord-333672-ef53l283 86 3 using use VBG cord-333672-ef53l283 86 4 larger large JJR cord-333672-ef53l283 86 5 sample sample NN cord-333672-ef53l283 86 6 sizes size NNS cord-333672-ef53l283 86 7 and and CC cord-333672-ef53l283 86 8 investigating investigate VBG cord-333672-ef53l283 86 9 the the DT cord-333672-ef53l283 86 10 effects effect NNS cord-333672-ef53l283 86 11 of of IN cord-333672-ef53l283 86 12 diet diet NN cord-333672-ef53l283 86 13 composition composition NN cord-333672-ef53l283 86 14 on on IN cord-333672-ef53l283 86 15 a a DT cord-333672-ef53l283 86 16 range range NN cord-333672-ef53l283 86 17 of of IN cord-333672-ef53l283 86 18 round round JJ cord-333672-ef53l283 86 19 - - HYPH cord-333672-ef53l283 86 20 the the DT cord-333672-ef53l283 86 21 - - HYPH cord-333672-ef53l283 86 22 clock clock NN cord-333672-ef53l283 86 23 postprandial postprandial JJ cord-333672-ef53l283 86 24 responses response NNS cord-333672-ef53l283 86 25 will will MD cord-333672-ef53l283 86 26 be be VB cord-333672-ef53l283 86 27 instructive instructive JJ cord-333672-ef53l283 86 28 . . . cord-333672-ef53l283 87 1 Studies study NNS cord-333672-ef53l283 87 2 of of IN cord-333672-ef53l283 87 3 adults adult NNS cord-333672-ef53l283 87 4 undergoing undergo VBG cord-333672-ef53l283 87 5 time time NN cord-333672-ef53l283 87 6 - - HYPH cord-333672-ef53l283 87 7 restricted restrict VBN cord-333672-ef53l283 87 8 eating eating NN cord-333672-ef53l283 87 9 ( ( -LRB- cord-333672-ef53l283 87 10 TRE TRE NNP cord-333672-ef53l283 87 11 ) ) -RRB- cord-333672-ef53l283 87 12 also also RB cord-333672-ef53l283 87 13 indicate indicate VBP cord-333672-ef53l283 87 14 that that IN cord-333672-ef53l283 87 15 optimising optimise VBG cord-333672-ef53l283 87 16 nutrient nutrient NN cord-333672-ef53l283 87 17 timing timing NN cord-333672-ef53l283 87 18 is be VBZ cord-333672-ef53l283 87 19 likely likely JJ cord-333672-ef53l283 87 20 to to TO cord-333672-ef53l283 87 21 be be VB cord-333672-ef53l283 87 22 important important JJ cord-333672-ef53l283 87 23 to to IN cord-333672-ef53l283 87 24 cardiometabolic cardiometabolic JJ cord-333672-ef53l283 87 25 health health NN cord-333672-ef53l283 87 26 , , , cord-333672-ef53l283 87 27 although although IN cord-333672-ef53l283 87 28 the the DT cord-333672-ef53l283 87 29 participants participant NNS cord-333672-ef53l283 87 30 in in IN cord-333672-ef53l283 87 31 these these DT cord-333672-ef53l283 87 32 studies study NNS cord-333672-ef53l283 87 33 have have VBP cord-333672-ef53l283 87 34 generally generally RB cord-333672-ef53l283 87 35 not not RB cord-333672-ef53l283 87 36 been be VBN cord-333672-ef53l283 87 37 shift shift JJ cord-333672-ef53l283 87 38 workers worker NNS cord-333672-ef53l283 87 39 . . . cord-333672-ef53l283 88 1 We -PRON- PRP cord-333672-ef53l283 88 2 arbitrarily arbitrarily RB cord-333672-ef53l283 88 3 define define VBP cord-333672-ef53l283 88 4 TRE TRE NNP cord-333672-ef53l283 88 5 as as IN cord-333672-ef53l283 88 6 consumption consumption NN cord-333672-ef53l283 88 7 of of IN cord-333672-ef53l283 88 8 all all DT cord-333672-ef53l283 88 9 calorie calorie NN cord-333672-ef53l283 88 10 - - HYPH cord-333672-ef53l283 88 11 containing contain VBG cord-333672-ef53l283 88 12 items item NNS cord-333672-ef53l283 88 13 within within IN cord-333672-ef53l283 88 14 a a DT cord-333672-ef53l283 88 15 period period NN cord-333672-ef53l283 88 16 of of IN cord-333672-ef53l283 88 17 12 12 CD cord-333672-ef53l283 88 18 h h NN cord-333672-ef53l283 88 19 or or CC cord-333672-ef53l283 88 20 less less JJR cord-333672-ef53l283 88 21 each each DT cord-333672-ef53l283 88 22 day day NN cord-333672-ef53l283 88 23 . . . cord-333672-ef53l283 89 1 Conversely conversely RB cord-333672-ef53l283 89 2 , , , cord-333672-ef53l283 89 3 we -PRON- PRP cord-333672-ef53l283 89 4 define define VBP cord-333672-ef53l283 89 5 _SP cord-333672-ef53l283 89 6 Workers Workers NNP cord-333672-ef53l283 89 7 should should MD cord-333672-ef53l283 89 8 restrict restrict VB cord-333672-ef53l283 89 9 consumption consumption NN cord-333672-ef53l283 89 10 of of IN cord-333672-ef53l283 89 11 all all DT cord-333672-ef53l283 89 12 items item NNS cord-333672-ef53l283 89 13 containing contain VBG cord-333672-ef53l283 89 14 > > XX cord-333672-ef53l283 89 15 5 5 CD cord-333672-ef53l283 89 16 calories calorie NNS cord-333672-ef53l283 89 17 to to IN cord-333672-ef53l283 89 18 a a DT cord-333672-ef53l283 89 19 6-to 6-to CD cord-333672-ef53l283 89 20 12-h 12-h CD cord-333672-ef53l283 89 21 period period NN cord-333672-ef53l283 89 22 each each DT cord-333672-ef53l283 89 23 day day NN cord-333672-ef53l283 89 24 , , , cord-333672-ef53l283 89 25 when when WRB cord-333672-ef53l283 89 26 possible possible JJ cord-333672-ef53l283 89 27 . . . cord-333672-ef53l283 90 1 They -PRON- PRP cord-333672-ef53l283 90 2 should should MD cord-333672-ef53l283 90 3 keep keep VB cord-333672-ef53l283 90 4 the the DT cord-333672-ef53l283 90 5 timing timing NN cord-333672-ef53l283 90 6 of of IN cord-333672-ef53l283 90 7 this this DT cord-333672-ef53l283 90 8 period period NN cord-333672-ef53l283 90 9 as as RB cord-333672-ef53l283 90 10 regular regular JJ cord-333672-ef53l283 90 11 as as IN cord-333672-ef53l283 90 12 is be VBZ cord-333672-ef53l283 90 13 feasible feasible JJ cord-333672-ef53l283 90 14 from from IN cord-333672-ef53l283 90 15 day day NN cord-333672-ef53l283 90 16 to to IN cord-333672-ef53l283 90 17 day day NN cord-333672-ef53l283 90 18 . . . cord-333672-ef53l283 91 1 Workers worker NNS cord-333672-ef53l283 91 2 should should MD cord-333672-ef53l283 91 3 self self NN cord-333672-ef53l283 91 4 - - HYPH cord-333672-ef53l283 91 5 select select VB cord-333672-ef53l283 91 6 the the DT cord-333672-ef53l283 91 7 timing timing NN cord-333672-ef53l283 91 8 of of IN cord-333672-ef53l283 91 9 this this DT cord-333672-ef53l283 91 10 period period NN cord-333672-ef53l283 91 11 , , , cord-333672-ef53l283 91 12 and and CC cord-333672-ef53l283 91 13 the the DT cord-333672-ef53l283 91 14 ideal ideal JJ cord-333672-ef53l283 91 15 time time NN cord-333672-ef53l283 91 16 for for IN cord-333672-ef53l283 91 17 this this DT cord-333672-ef53l283 91 18 period period NN cord-333672-ef53l283 91 19 may may MD cord-333672-ef53l283 91 20 be be VB cord-333672-ef53l283 91 21 relatively relatively RB cord-333672-ef53l283 91 22 early early JJ cord-333672-ef53l283 91 23 in in IN cord-333672-ef53l283 91 24 each each DT cord-333672-ef53l283 91 25 worker worker NN cord-333672-ef53l283 91 26 's 's POS cord-333672-ef53l283 91 27 biological biological JJ cord-333672-ef53l283 91 28 daytime daytime NN cord-333672-ef53l283 91 29 . . . cord-333672-ef53l283 92 1 We -PRON- PRP cord-333672-ef53l283 92 2 therefore therefore RB cord-333672-ef53l283 92 3 recommend recommend VBP cord-333672-ef53l283 92 4 that that IN cord-333672-ef53l283 92 5 workers worker NNS cord-333672-ef53l283 92 6 select select VBP cord-333672-ef53l283 92 7 a a DT cord-333672-ef53l283 92 8 caloric caloric JJ cord-333672-ef53l283 92 9 period period NN cord-333672-ef53l283 92 10 that that WDT cord-333672-ef53l283 92 11 finishes finish VBZ cord-333672-ef53l283 92 12 at at IN cord-333672-ef53l283 92 13 least least JJS cord-333672-ef53l283 92 14 3 3 CD cord-333672-ef53l283 92 15 h h NN cord-333672-ef53l283 92 16 before before IN cord-333672-ef53l283 92 17 their -PRON- PRP$ cord-333672-ef53l283 92 18 most most RBS cord-333672-ef53l283 92 19 common common JJ cord-333672-ef53l283 92 20 bedtime bedtime NN cord-333672-ef53l283 92 21 . . . cord-333672-ef53l283 93 1 Workers worker NNS cord-333672-ef53l283 93 2 who who WP cord-333672-ef53l283 93 3 have have VBP cord-333672-ef53l283 93 4 poor poor JJ cord-333672-ef53l283 93 5 cardiometabolic cardiometabolic JJ cord-333672-ef53l283 93 6 health health NN cord-333672-ef53l283 93 7 should should MD cord-333672-ef53l283 93 8 aim aim VB cord-333672-ef53l283 93 9 to to TO cord-333672-ef53l283 93 10 consume consume VB cord-333672-ef53l283 93 11 at at IN cord-333672-ef53l283 93 12 least least JJS cord-333672-ef53l283 93 13 half half NN cord-333672-ef53l283 93 14 of of IN cord-333672-ef53l283 93 15 daily daily JJ cord-333672-ef53l283 93 16 energy energy NN cord-333672-ef53l283 93 17 intake intake NN cord-333672-ef53l283 93 18 in in IN cord-333672-ef53l283 93 19 the the DT cord-333672-ef53l283 93 20 first first JJ cord-333672-ef53l283 93 21 half half NN cord-333672-ef53l283 93 22 of of IN cord-333672-ef53l283 93 23 the the DT cord-333672-ef53l283 93 24 caloric caloric JJ cord-333672-ef53l283 93 25 period period NN cord-333672-ef53l283 93 26 ( ( -LRB- cord-333672-ef53l283 93 27 e.g. e.g. RB cord-333672-ef53l283 93 28 , , , cord-333672-ef53l283 93 29 by by IN cord-333672-ef53l283 93 30 increasing increase VBG cord-333672-ef53l283 93 31 the the DT cord-333672-ef53l283 93 32 size size NN cord-333672-ef53l283 93 33 of of IN cord-333672-ef53l283 93 34 breakfast breakfast NN cord-333672-ef53l283 93 35 and and CC cord-333672-ef53l283 93 36 reducing reduce VBG cord-333672-ef53l283 93 37 the the DT cord-333672-ef53l283 93 38 size size NN cord-333672-ef53l283 93 39 of of IN cord-333672-ef53l283 93 40 dinner dinner NN cord-333672-ef53l283 93 41 ) ) -RRB- cord-333672-ef53l283 93 42 . . . cord-333672-ef53l283 94 1 This this DT cord-333672-ef53l283 94 2 is be VBZ cord-333672-ef53l283 94 3 less less RBR cord-333672-ef53l283 94 4 relevant relevant JJ cord-333672-ef53l283 94 5 to to IN cord-333672-ef53l283 94 6 people people NNS cord-333672-ef53l283 94 7 who who WP cord-333672-ef53l283 94 8 exercise exercise VBP cord-333672-ef53l283 94 9 in in IN cord-333672-ef53l283 94 10 the the DT cord-333672-ef53l283 94 11 second second JJ cord-333672-ef53l283 94 12 half half NN cord-333672-ef53l283 94 13 of of IN cord-333672-ef53l283 94 14 their -PRON- PRP$ cord-333672-ef53l283 94 15 caloric caloric JJ cord-333672-ef53l283 94 16 period period NN cord-333672-ef53l283 94 17 . . . cord-333672-ef53l283 95 1 Workers worker NNS cord-333672-ef53l283 95 2 should should MD cord-333672-ef53l283 95 3 also also RB cord-333672-ef53l283 95 4 aim aim VB cord-333672-ef53l283 95 5 to to TO cord-333672-ef53l283 95 6 evenly evenly RB cord-333672-ef53l283 95 7 divide divide VB cord-333672-ef53l283 95 8 their -PRON- PRP$ cord-333672-ef53l283 95 9 protein protein NN cord-333672-ef53l283 95 10 intakes intake NNS cord-333672-ef53l283 95 11 between between IN cord-333672-ef53l283 95 12 dietary dietary JJ cord-333672-ef53l283 95 13 events event NNS cord-333672-ef53l283 95 14 . . . cord-333672-ef53l283 96 1 As as IN cord-333672-ef53l283 96 2 a a DT cord-333672-ef53l283 96 3 starting starting NN cord-333672-ef53l283 96 4 point point NN cord-333672-ef53l283 96 5 , , , cord-333672-ef53l283 96 6 we -PRON- PRP cord-333672-ef53l283 96 7 recommend recommend VBP cord-333672-ef53l283 96 8 that that IN cord-333672-ef53l283 96 9 workers worker NNS cord-333672-ef53l283 96 10 aim aim VBP cord-333672-ef53l283 96 11 to to TO cord-333672-ef53l283 96 12 consume consume VB cord-333672-ef53l283 96 13 ∼ ∼ NNP cord-333672-ef53l283 96 14 0.4 0.4 CD cord-333672-ef53l283 96 15 g g NN cord-333672-ef53l283 96 16 protein protein NN cord-333672-ef53l283 96 17 per per IN cord-333672-ef53l283 96 18 kg kg NN cord-333672-ef53l283 96 19 bodyweight bodyweight NN cord-333672-ef53l283 96 20 at at IN cord-333672-ef53l283 96 21 each each DT cord-333672-ef53l283 96 22 of of IN cord-333672-ef53l283 96 23 3 3 CD cord-333672-ef53l283 96 24 to to TO cord-333672-ef53l283 96 25 4 4 CD cord-333672-ef53l283 96 26 evenly evenly RB cord-333672-ef53l283 96 27 - - HYPH cord-333672-ef53l283 96 28 spaced space VBN cord-333672-ef53l283 96 29 dietary dietary JJ cord-333672-ef53l283 96 30 events event NNS cord-333672-ef53l283 96 31 each each DT cord-333672-ef53l283 96 32 day day NN cord-333672-ef53l283 96 33 ( ( -LRB- cord-333672-ef53l283 96 34 43 43 CD cord-333672-ef53l283 96 35 ) ) -RRB- cord-333672-ef53l283 96 36 . . . cord-333672-ef53l283 97 1 Workers worker NNS cord-333672-ef53l283 97 2 who who WP cord-333672-ef53l283 97 3 have have VBP cord-333672-ef53l283 97 4 poor poor JJ cord-333672-ef53l283 97 5 glycaemic glycaemic JJ cord-333672-ef53l283 97 6 control control NN cord-333672-ef53l283 97 7 should should MD cord-333672-ef53l283 97 8 consume consume VB cord-333672-ef53l283 97 9 carbohydrate carbohydrate NN cord-333672-ef53l283 97 10 - - HYPH cord-333672-ef53l283 97 11 rich rich JJ cord-333672-ef53l283 97 12 foods food NNS cord-333672-ef53l283 97 13 last last JJ cord-333672-ef53l283 97 14 at at IN cord-333672-ef53l283 97 15 dietary dietary JJ cord-333672-ef53l283 97 16 events event NNS cord-333672-ef53l283 97 17 , , , cord-333672-ef53l283 97 18 when when WRB cord-333672-ef53l283 97 19 practical practical JJ cord-333672-ef53l283 97 20 ( ( -LRB- cord-333672-ef53l283 97 21 e.g. e.g. RB cord-333672-ef53l283 97 22 , , , cord-333672-ef53l283 97 23 consuming consume VBG cord-333672-ef53l283 97 24 fibre fibre NN cord-333672-ef53l283 97 25 - - HYPH cord-333672-ef53l283 97 26 and and CC cord-333672-ef53l283 97 27 protein protein NN cord-333672-ef53l283 97 28 - - HYPH cord-333672-ef53l283 97 29 rich rich JJ cord-333672-ef53l283 97 30 salads salad NNS cord-333672-ef53l283 97 31 before before IN cord-333672-ef53l283 97 32 meals meal NNS cord-333672-ef53l283 97 33 or or CC cord-333672-ef53l283 97 34 eating eat VBG cord-333672-ef53l283 97 35 meat meat NN cord-333672-ef53l283 97 36 and and CC cord-333672-ef53l283 97 37 vegetable vegetable NN cord-333672-ef53l283 97 38 foods food NNS cord-333672-ef53l283 97 39 before before IN cord-333672-ef53l283 97 40 carbohydrate carbohydrate NN cord-333672-ef53l283 97 41 - - HYPH cord-333672-ef53l283 97 42 rich rich JJ cord-333672-ef53l283 97 43 foods food NNS cord-333672-ef53l283 97 44 ) ) -RRB- cord-333672-ef53l283 97 45 . . . cord-333672-ef53l283 98 1 When when WRB cord-333672-ef53l283 98 2 workers worker NNS cord-333672-ef53l283 98 3 feel feel VBP cord-333672-ef53l283 98 4 it -PRON- PRP cord-333672-ef53l283 98 5 would would MD cord-333672-ef53l283 98 6 be be VB cord-333672-ef53l283 98 7 beneficial beneficial JJ cord-333672-ef53l283 98 8 to to TO cord-333672-ef53l283 98 9 snack snack VB cord-333672-ef53l283 98 10 outside outside RB cord-333672-ef53l283 98 11 of of IN cord-333672-ef53l283 98 12 the the DT cord-333672-ef53l283 98 13 caloric caloric JJ cord-333672-ef53l283 98 14 period period NN cord-333672-ef53l283 98 15 ( ( -LRB- cord-333672-ef53l283 98 16 e.g. e.g. RB cord-333672-ef53l283 98 17 , , , cord-333672-ef53l283 98 18 to to TO cord-333672-ef53l283 98 19 abate abate VB cord-333672-ef53l283 98 20 hunger hunger NN cord-333672-ef53l283 98 21 and/or and/or CC cord-333672-ef53l283 98 22 support support NN cord-333672-ef53l283 98 23 alertness alertness NN cord-333672-ef53l283 98 24 ) ) -RRB- cord-333672-ef53l283 98 25 , , , cord-333672-ef53l283 98 26 they -PRON- PRP cord-333672-ef53l283 98 27 may may MD cord-333672-ef53l283 98 28 benefit benefit VB cord-333672-ef53l283 98 29 from from IN cord-333672-ef53l283 98 30 consuming consume VBG cord-333672-ef53l283 98 31 relatively relatively RB cord-333672-ef53l283 98 32 small small JJ cord-333672-ef53l283 98 33 ( ( -LRB- cord-333672-ef53l283 98 34 i.e. i.e. FW cord-333672-ef53l283 98 35 , , , cord-333672-ef53l283 98 36 ∼10 ∼10 VBN cord-333672-ef53l283 98 37 - - HYPH cord-333672-ef53l283 98 38 20 20 CD cord-333672-ef53l283 98 39 % % NN cord-333672-ef53l283 98 40 daily daily JJ cord-333672-ef53l283 98 41 caloric caloric JJ cord-333672-ef53l283 98 42 intake intake NN cord-333672-ef53l283 98 43 ) ) -RRB- cord-333672-ef53l283 98 44 , , , cord-333672-ef53l283 98 45 minimally minimally RB cord-333672-ef53l283 98 46 processed process VBN cord-333672-ef53l283 98 47 , , , cord-333672-ef53l283 98 48 micronutrient micronutrient NN cord-333672-ef53l283 98 49 - - HYPH cord-333672-ef53l283 98 50 dense dense JJ cord-333672-ef53l283 98 51 , , , cord-333672-ef53l283 98 52 satiating satiating JJ cord-333672-ef53l283 98 53 , , , cord-333672-ef53l283 98 54 easy easy JJ cord-333672-ef53l283 98 55 to to TO cord-333672-ef53l283 98 56 digest digest VB cord-333672-ef53l283 98 57 , , , cord-333672-ef53l283 98 58 convenient convenient JJ cord-333672-ef53l283 98 59 snacks snack NNS cord-333672-ef53l283 98 60 . . . cord-333672-ef53l283 99 1 We -PRON- PRP cord-333672-ef53l283 99 2 hypothesise hypothesise VBP cord-333672-ef53l283 99 3 that that IN cord-333672-ef53l283 99 4 relatively relatively RB cord-333672-ef53l283 99 5 high high JJ cord-333672-ef53l283 99 6 - - HYPH cord-333672-ef53l283 99 7 protein protein NN cord-333672-ef53l283 99 8 , , , cord-333672-ef53l283 99 9 low low JJ cord-333672-ef53l283 99 10 carbohydrate carbohydrate NN cord-333672-ef53l283 99 11 snacks snack NNS cord-333672-ef53l283 99 12 are be VBP cord-333672-ef53l283 99 13 ideal ideal JJ cord-333672-ef53l283 99 14 at at IN cord-333672-ef53l283 99 15 these these DT cord-333672-ef53l283 99 16 times time NNS cord-333672-ef53l283 99 17 ( ( -LRB- cord-333672-ef53l283 99 18 e.g. e.g. RB cord-333672-ef53l283 99 19 , , , cord-333672-ef53l283 99 20 snack snack NN cord-333672-ef53l283 99 21 items item NNS cord-333672-ef53l283 99 22 may may MD cord-333672-ef53l283 99 23 include include VB cord-333672-ef53l283 99 24 boiled boil VBN cord-333672-ef53l283 99 25 eggs egg NNS cord-333672-ef53l283 99 26 , , , cord-333672-ef53l283 99 27 dairy dairy NN cord-333672-ef53l283 99 28 products product NNS cord-333672-ef53l283 99 29 , , , cord-333672-ef53l283 99 30 minimally minimally RB cord-333672-ef53l283 99 31 - - HYPH cord-333672-ef53l283 99 32 processed process VBN cord-333672-ef53l283 99 33 fish fish NN cord-333672-ef53l283 99 34 jerky jerky NN cord-333672-ef53l283 99 35 or or CC cord-333672-ef53l283 99 36 meat meat NN cord-333672-ef53l283 99 37 jerky jerky NN cord-333672-ef53l283 99 38 , , , cord-333672-ef53l283 99 39 high high JJ cord-333672-ef53l283 99 40 - - HYPH cord-333672-ef53l283 99 41 protein protein NN cord-333672-ef53l283 99 42 drinks drink NNS cord-333672-ef53l283 99 43 , , , cord-333672-ef53l283 99 44 nuts nuts JJ cord-333672-ef53l283 99 45 , , , cord-333672-ef53l283 99 46 whole whole JJ cord-333672-ef53l283 99 47 vegetables vegetable NNS cord-333672-ef53l283 99 48 , , , cord-333672-ef53l283 99 49 and/or and/or CC cord-333672-ef53l283 99 50 low low JJ cord-333672-ef53l283 99 51 - - HYPH cord-333672-ef53l283 99 52 sugar sugar NN cord-333672-ef53l283 99 53 whole whole JJ cord-333672-ef53l283 99 54 fruits fruit NNS cord-333672-ef53l283 99 55 such such JJ cord-333672-ef53l283 99 56 as as IN cord-333672-ef53l283 99 57 berries berry NNS cord-333672-ef53l283 99 58 ) ) -RRB- cord-333672-ef53l283 99 59 . . . cord-333672-ef53l283 100 1 If if IN cord-333672-ef53l283 100 2 their -PRON- PRP$ cord-333672-ef53l283 100 3 goal goal NN cord-333672-ef53l283 100 4 is be VBZ cord-333672-ef53l283 100 5 to to TO cord-333672-ef53l283 100 6 support support VB cord-333672-ef53l283 100 7 cognitive cognitive JJ cord-333672-ef53l283 100 8 function function NN cord-333672-ef53l283 100 9 during during IN cord-333672-ef53l283 100 10 shifts shift NNS cord-333672-ef53l283 100 11 , , , cord-333672-ef53l283 100 12 workers worker NNS cord-333672-ef53l283 100 13 may may MD cord-333672-ef53l283 100 14 benefit benefit VB cord-333672-ef53l283 100 15 from from IN cord-333672-ef53l283 100 16 individual individual JJ cord-333672-ef53l283 100 17 doses dose NNS cord-333672-ef53l283 100 18 of of IN cord-333672-ef53l283 100 19 1 1 CD cord-333672-ef53l283 100 20 - - SYM cord-333672-ef53l283 100 21 4 4 CD cord-333672-ef53l283 100 22 mg mg NN cord-333672-ef53l283 100 23 caffeine caffeine NN cord-333672-ef53l283 100 24 per per IN cord-333672-ef53l283 100 25 kg kg NN cord-333672-ef53l283 100 26 bodyweight bodyweight NN cord-333672-ef53l283 100 27 , , , cord-333672-ef53l283 100 28 favouring favour VBG cord-333672-ef53l283 100 29 the the DT cord-333672-ef53l283 100 30 upper upper JJ cord-333672-ef53l283 100 31 end end NN cord-333672-ef53l283 100 32 of of IN cord-333672-ef53l283 100 33 this this DT cord-333672-ef53l283 100 34 range range NN cord-333672-ef53l283 100 35 if if IN cord-333672-ef53l283 100 36 short short JJ cord-333672-ef53l283 100 37 on on IN cord-333672-ef53l283 100 38 sleep sleep NN cord-333672-ef53l283 100 39 ( ( -LRB- cord-333672-ef53l283 100 40 44 44 CD cord-333672-ef53l283 100 41 ) ) -RRB- cord-333672-ef53l283 100 42 . . . cord-333672-ef53l283 101 1 Repeated repeat VBN cord-333672-ef53l283 101 2 doses dose NNS cord-333672-ef53l283 101 3 of of IN cord-333672-ef53l283 101 4 caffeine caffeine NN cord-333672-ef53l283 101 5 every every DT cord-333672-ef53l283 101 6 2 2 CD cord-333672-ef53l283 101 7 h h NN cord-333672-ef53l283 101 8 or or CC cord-333672-ef53l283 101 9 so so RB cord-333672-ef53l283 101 10 may may MD cord-333672-ef53l283 101 11 maximally maximally RB cord-333672-ef53l283 101 12 support support VB cord-333672-ef53l283 101 13 cognitive cognitive JJ cord-333672-ef53l283 101 14 function function NN cord-333672-ef53l283 101 15 during during IN cord-333672-ef53l283 101 16 extended extended JJ cord-333672-ef53l283 101 17 wakefulness wakefulness NN cord-333672-ef53l283 101 18 ( ( -LRB- cord-333672-ef53l283 101 19 45 45 CD cord-333672-ef53l283 101 20 ) ) -RRB- cord-333672-ef53l283 101 21 . . . cord-333672-ef53l283 102 1 As as IN cord-333672-ef53l283 102 2 consuming consume VBG cord-333672-ef53l283 102 3 caffeine caffeine NN cord-333672-ef53l283 102 4 as as IN cord-333672-ef53l283 102 5 gum gum NN cord-333672-ef53l283 102 6 leads lead VBZ cord-333672-ef53l283 102 7 to to IN cord-333672-ef53l283 102 8 faster fast JJR cord-333672-ef53l283 102 9 absorption absorption NN cord-333672-ef53l283 102 10 than than IN cord-333672-ef53l283 102 11 consuming consume VBG cord-333672-ef53l283 102 12 caffeine caffeine NN cord-333672-ef53l283 102 13 as as IN cord-333672-ef53l283 102 14 capsules capsule NNS cord-333672-ef53l283 102 15 ( ( -LRB- cord-333672-ef53l283 102 16 46 46 CD cord-333672-ef53l283 102 17 ) ) -RRB- cord-333672-ef53l283 102 18 , , , cord-333672-ef53l283 102 19 caffeinated caffeinated JJ cord-333672-ef53l283 102 20 gum gum NN cord-333672-ef53l283 102 21 may may MD cord-333672-ef53l283 102 22 be be VB cord-333672-ef53l283 102 23 particularly particularly RB cord-333672-ef53l283 102 24 helpful helpful JJ cord-333672-ef53l283 102 25 if if IN cord-333672-ef53l283 102 26 the the DT cord-333672-ef53l283 102 27 goal goal NN cord-333672-ef53l283 102 28 is be VBZ cord-333672-ef53l283 102 29 to to TO cord-333672-ef53l283 102 30 affect affect VB cord-333672-ef53l283 102 31 cognition cognition NN cord-333672-ef53l283 102 32 as as RB cord-333672-ef53l283 102 33 quickly quickly RB cord-333672-ef53l283 102 34 as as IN cord-333672-ef53l283 102 35 possible possible JJ cord-333672-ef53l283 102 36 . . . cord-333672-ef53l283 103 1 Since since IN cord-333672-ef53l283 103 2 mistimed mistimed JJ cord-333672-ef53l283 103 3 caffeine caffeine NN cord-333672-ef53l283 103 4 intake intake NN cord-333672-ef53l283 103 5 impairs impair NNS cord-333672-ef53l283 103 6 sleep sleep NN cord-333672-ef53l283 103 7 , , , cord-333672-ef53l283 103 8 workers worker NNS cord-333672-ef53l283 103 9 should should MD cord-333672-ef53l283 103 10 also also RB cord-333672-ef53l283 103 11 stop stop VB cord-333672-ef53l283 103 12 consuming consume VBG cord-333672-ef53l283 103 13 caffeine caffeine NN cord-333672-ef53l283 103 14 at at IN cord-333672-ef53l283 103 15 least least JJS cord-333672-ef53l283 103 16 7 7 CD cord-333672-ef53l283 103 17 h h NN cord-333672-ef53l283 103 18 before before IN cord-333672-ef53l283 103 19 the the DT cord-333672-ef53l283 103 20 main main JJ cord-333672-ef53l283 103 21 sleep sleep NN cord-333672-ef53l283 103 22 period period NN cord-333672-ef53l283 103 23 , , , cord-333672-ef53l283 103 24 if if IN cord-333672-ef53l283 103 25 possible possible JJ cord-333672-ef53l283 103 26 ( ( -LRB- cord-333672-ef53l283 103 27 47 47 CD cord-333672-ef53l283 103 28 ) ) -RRB- cord-333672-ef53l283 103 29 . . . cord-333672-ef53l283 104 1 Individuals individual NNS cord-333672-ef53l283 104 2 differ differ VBP cord-333672-ef53l283 104 3 remarkably remarkably RB cord-333672-ef53l283 104 4 in in IN cord-333672-ef53l283 104 5 their -PRON- PRP$ cord-333672-ef53l283 104 6 responses response NNS cord-333672-ef53l283 104 7 to to IN cord-333672-ef53l283 104 8 caffeine caffeine NN cord-333672-ef53l283 104 9 ingestion ingestion NN cord-333672-ef53l283 104 10 , , , cord-333672-ef53l283 104 11 so so IN cord-333672-ef53l283 104 12 they -PRON- PRP cord-333672-ef53l283 104 13 should should MD cord-333672-ef53l283 104 14 moderate moderate VB cord-333672-ef53l283 104 15 their -PRON- PRP$ cord-333672-ef53l283 104 16 intakes intake NNS cord-333672-ef53l283 104 17 according accord VBG cord-333672-ef53l283 104 18 to to IN cord-333672-ef53l283 104 19 their -PRON- PRP$ cord-333672-ef53l283 104 20 individual individual JJ cord-333672-ef53l283 104 21 responses response NNS cord-333672-ef53l283 104 22 . . . cord-333672-ef53l283 105 1 As as IN cord-333672-ef53l283 105 2 a a DT cord-333672-ef53l283 105 3 starting starting NN cord-333672-ef53l283 105 4 point point NN cord-333672-ef53l283 105 5 , , , cord-333672-ef53l283 105 6 we -PRON- PRP cord-333672-ef53l283 105 7 recommend recommend VBP cord-333672-ef53l283 105 8 consuming consume VBG cord-333672-ef53l283 105 9 no no DT cord-333672-ef53l283 105 10 more more JJR cord-333672-ef53l283 105 11 than than IN cord-333672-ef53l283 105 12 6 6 CD cord-333672-ef53l283 105 13 mg mg NN cord-333672-ef53l283 105 14 caffeine caffeine NN cord-333672-ef53l283 105 15 per per IN cord-333672-ef53l283 105 16 kg kg NN cord-333672-ef53l283 105 17 bodyweight bodyweight NN cord-333672-ef53l283 105 18 per per IN cord-333672-ef53l283 105 19 24 24 CD cord-333672-ef53l283 105 20 h. h. NN cord-333672-ef53l283 105 21 Creatine creatine NN cord-333672-ef53l283 105 22 monohydrate monohydrate NN cord-333672-ef53l283 105 23 consumption consumption NN cord-333672-ef53l283 105 24 may may MD cord-333672-ef53l283 105 25 help help VB cord-333672-ef53l283 105 26 shift shift VB cord-333672-ef53l283 105 27 workers worker NNS cord-333672-ef53l283 105 28 cope cope VB cord-333672-ef53l283 105 29 with with IN cord-333672-ef53l283 105 30 sleep sleep NN cord-333672-ef53l283 105 31 loss loss NN cord-333672-ef53l283 105 32 . . . cord-333672-ef53l283 106 1 During during IN cord-333672-ef53l283 106 2 periods period NNS cord-333672-ef53l283 106 3 of of IN cord-333672-ef53l283 106 4 insufficient insufficient JJ cord-333672-ef53l283 106 5 sleep sleep NN cord-333672-ef53l283 106 6 , , , cord-333672-ef53l283 106 7 we -PRON- PRP cord-333672-ef53l283 106 8 tentatively tentatively RB cord-333672-ef53l283 106 9 recommend recommend VBP cord-333672-ef53l283 106 10 that that IN cord-333672-ef53l283 106 11 shift shift NN cord-333672-ef53l283 106 12 workers worker NNS cord-333672-ef53l283 106 13 consume consume VBP cord-333672-ef53l283 106 14 0.1 0.1 CD cord-333672-ef53l283 106 15 g g NN cord-333672-ef53l283 106 16 creatine creatine NN cord-333672-ef53l283 106 17 monohydrate monohydrate NN cord-333672-ef53l283 106 18 per per IN cord-333672-ef53l283 106 19 kg kg NN cord-333672-ef53l283 106 20 bodyweight bodyweight NN cord-333672-ef53l283 106 21 per per IN cord-333672-ef53l283 106 22 day day NN cord-333672-ef53l283 106 23 . . . cord-333672-ef53l283 107 1 Because because IN cord-333672-ef53l283 107 2 of of IN cord-333672-ef53l283 107 3 its -PRON- PRP$ cord-333672-ef53l283 107 4 potential potential JJ cord-333672-ef53l283 107 5 alertness alertness NN cord-333672-ef53l283 107 6 - - HYPH cord-333672-ef53l283 107 7 boosting boost VBG cord-333672-ef53l283 107 8 properties property NNS cord-333672-ef53l283 107 9 , , , cord-333672-ef53l283 107 10 we -PRON- PRP cord-333672-ef53l283 107 11 speculate speculate VBP cord-333672-ef53l283 107 12 that that IN cord-333672-ef53l283 107 13 the the DT cord-333672-ef53l283 107 14 ideal ideal JJ cord-333672-ef53l283 107 15 time time NN cord-333672-ef53l283 107 16 to to TO cord-333672-ef53l283 107 17 consume consume VB cord-333672-ef53l283 107 18 creatine creatine NN cord-333672-ef53l283 107 19 is be VBZ cord-333672-ef53l283 107 20 with with IN cord-333672-ef53l283 107 21 the the DT cord-333672-ef53l283 107 22 first first JJ cord-333672-ef53l283 107 23 meal meal NN cord-333672-ef53l283 107 24 of of IN cord-333672-ef53l283 107 25 each each DT cord-333672-ef53l283 107 26 day day NN cord-333672-ef53l283 107 27 . . . cord-333672-ef53l283 108 1 Well well RB cord-333672-ef53l283 108 2 - - HYPH cord-333672-ef53l283 108 3 timed time VBN cord-333672-ef53l283 108 4 melatonin melatonin NN cord-333672-ef53l283 108 5 use use NN cord-333672-ef53l283 108 6 may may MD cord-333672-ef53l283 108 7 help help VB cord-333672-ef53l283 108 8 some some DT cord-333672-ef53l283 108 9 shift shift NN cord-333672-ef53l283 108 10 workers worker NNS cord-333672-ef53l283 108 11 adapt adapt VBP cord-333672-ef53l283 108 12 to to IN cord-333672-ef53l283 108 13 new new JJ cord-333672-ef53l283 108 14 work work NN cord-333672-ef53l283 108 15 schedules schedule NNS cord-333672-ef53l283 108 16 and and CC cord-333672-ef53l283 108 17 sleep sleep VB cord-333672-ef53l283 108 18 better well RBR cord-333672-ef53l283 108 19 during during IN cord-333672-ef53l283 108 20 these these DT cord-333672-ef53l283 108 21 transitions transition NNS cord-333672-ef53l283 108 22 . . . cord-333672-ef53l283 109 1 We -PRON- PRP cord-333672-ef53l283 109 2 tentatively tentatively RB cord-333672-ef53l283 109 3 recommend recommend VBP cord-333672-ef53l283 109 4 that that IN cord-333672-ef53l283 109 5 workers worker NNS cord-333672-ef53l283 109 6 consume consume VBP cord-333672-ef53l283 109 7 a a DT cord-333672-ef53l283 109 8 dose dose NN cord-333672-ef53l283 109 9 of of IN cord-333672-ef53l283 109 10 0.3 0.3 CD cord-333672-ef53l283 109 11 - - SYM cord-333672-ef53l283 109 12 5 5 CD cord-333672-ef53l283 109 13 mg mg NNP cord-333672-ef53l283 109 14 melatonin melatonin NN cord-333672-ef53l283 109 15 at at IN cord-333672-ef53l283 109 16 these these DT cord-333672-ef53l283 109 17 times time NNS cord-333672-ef53l283 109 18 , , , cord-333672-ef53l283 109 19 beginning begin VBG cord-333672-ef53l283 109 20 with with IN cord-333672-ef53l283 109 21 a a DT cord-333672-ef53l283 109 22 dose dose NN cord-333672-ef53l283 109 23 at at IN cord-333672-ef53l283 109 24 the the DT cord-333672-ef53l283 109 25 low low JJ cord-333672-ef53l283 109 26 end end NN cord-333672-ef53l283 109 27 of of IN cord-333672-ef53l283 109 28 this this DT cord-333672-ef53l283 109 29 range range NN cord-333672-ef53l283 109 30 and and CC cord-333672-ef53l283 109 31 adjusting adjust VBG cord-333672-ef53l283 109 32 the the DT cord-333672-ef53l283 109 33 dose dose NN cord-333672-ef53l283 109 34 according accord VBG cord-333672-ef53l283 109 35 to to IN cord-333672-ef53l283 109 36 responses response NNS cord-333672-ef53l283 109 37 . . . cord-333672-ef53l283 110 1 Because because IN cord-333672-ef53l283 110 2 of of IN cord-333672-ef53l283 110 3 its -PRON- PRP$ cord-333672-ef53l283 110 4 potent potent JJ cord-333672-ef53l283 110 5 chronobiotic chronobiotic JJ cord-333672-ef53l283 110 6 properties property NNS cord-333672-ef53l283 110 7 , , , cord-333672-ef53l283 110 8 the the DT cord-333672-ef53l283 110 9 optimal optimal JJ cord-333672-ef53l283 110 10 timing timing NN cord-333672-ef53l283 110 11 of of IN cord-333672-ef53l283 110 12 melatonin melatonin NN cord-333672-ef53l283 110 13 ingestion ingestion NN cord-333672-ef53l283 110 14 depends depend VBZ cord-333672-ef53l283 110 15 on on IN cord-333672-ef53l283 110 16 variables variable NNS cord-333672-ef53l283 110 17 such such JJ cord-333672-ef53l283 110 18 as as IN cord-333672-ef53l283 110 19 the the DT cord-333672-ef53l283 110 20 individual individual NN cord-333672-ef53l283 110 21 's 's POS cord-333672-ef53l283 110 22 circadian circadian NN cord-333672-ef53l283 110 23 phenotype phenotype NN cord-333672-ef53l283 110 24 and and CC cord-333672-ef53l283 110 25 work work NN cord-333672-ef53l283 110 26 schedule schedule NN cord-333672-ef53l283 110 27 . . . cord-333672-ef53l283 111 1 We -PRON- PRP cord-333672-ef53l283 111 2 therefore therefore RB cord-333672-ef53l283 111 3 do do VBP cord-333672-ef53l283 111 4 not not RB cord-333672-ef53l283 111 5 offer offer VB cord-333672-ef53l283 111 6 guidance guidance NN cord-333672-ef53l283 111 7 related relate VBN cord-333672-ef53l283 111 8 to to IN cord-333672-ef53l283 111 9 melatonin melatonin NN cord-333672-ef53l283 111 10 ingestion ingestion NN cord-333672-ef53l283 111 11 timing timing NN cord-333672-ef53l283 111 12 . . . cord-333672-ef53l283 112 1 intermittent intermittent JJ cord-333672-ef53l283 112 2 fasting fast VBG cord-333672-ef53l283 112 3 as as IN cord-333672-ef53l283 112 4 periodic periodic JJ cord-333672-ef53l283 112 5 abstinence abstinence NN cord-333672-ef53l283 112 6 from from IN cord-333672-ef53l283 112 7 consumption consumption NN cord-333672-ef53l283 112 8 of of IN cord-333672-ef53l283 112 9 any any DT cord-333672-ef53l283 112 10 calories calorie NNS cord-333672-ef53l283 112 11 for for IN cord-333672-ef53l283 112 12 at at RB cord-333672-ef53l283 112 13 least least RBS cord-333672-ef53l283 112 14 24 24 CD cord-333672-ef53l283 112 15 h. h. NN cord-333672-ef53l283 112 16 Skipping skipping NN cord-333672-ef53l283 112 17 breakfast breakfast NN cord-333672-ef53l283 112 18 is be VBZ cord-333672-ef53l283 112 19 one one CD cord-333672-ef53l283 112 20 way way NN cord-333672-ef53l283 112 21 to to TO cord-333672-ef53l283 112 22 implement implement VB cord-333672-ef53l283 112 23 TRE TRE NNP cord-333672-ef53l283 112 24 , , , cord-333672-ef53l283 112 25 and and CC cord-333672-ef53l283 112 26 doing do VBG cord-333672-ef53l283 112 27 so so RB cord-333672-ef53l283 112 28 leads lead VBZ cord-333672-ef53l283 112 29 to to IN cord-333672-ef53l283 112 30 late late JJ cord-333672-ef53l283 112 31 TRE TRE NNP cord-333672-ef53l283 112 32 . . . cord-333672-ef53l283 113 1 While while IN cord-333672-ef53l283 113 2 breakfast breakfast NN cord-333672-ef53l283 113 3 - - HYPH cord-333672-ef53l283 113 4 skipping skipping NN cord-333672-ef53l283 113 5 is be VBZ cord-333672-ef53l283 113 6 a a DT cord-333672-ef53l283 113 7 controversial controversial JJ cord-333672-ef53l283 113 8 topic topic NN cord-333672-ef53l283 113 9 , , , cord-333672-ef53l283 113 10 epidemiologic epidemiologic JJ cord-333672-ef53l283 113 11 studies study NNS cord-333672-ef53l283 113 12 have have VBP cord-333672-ef53l283 113 13 tended tend VBN cord-333672-ef53l283 113 14 to to TO cord-333672-ef53l283 113 15 associate associate VB cord-333672-ef53l283 113 16 breakfast breakfast NN cord-333672-ef53l283 113 17 consumption consumption NN cord-333672-ef53l283 113 18 with with IN cord-333672-ef53l283 113 19 lower low JJR cord-333672-ef53l283 113 20 risk risk NN cord-333672-ef53l283 113 21 of of IN cord-333672-ef53l283 113 22 developing develop VBG cord-333672-ef53l283 113 23 cardiometabolic cardiometabolic JJ cord-333672-ef53l283 113 24 diseases disease NNS cord-333672-ef53l283 113 25 such such JJ cord-333672-ef53l283 113 26 as as IN cord-333672-ef53l283 113 27 heart heart NN cord-333672-ef53l283 113 28 disease disease NN cord-333672-ef53l283 113 29 and and CC cord-333672-ef53l283 113 30 type type NN cord-333672-ef53l283 113 31 - - HYPH cord-333672-ef53l283 113 32 two two CD cord-333672-ef53l283 113 33 diabetes diabete NNS cord-333672-ef53l283 113 34 ( ( -LRB- cord-333672-ef53l283 113 35 53 53 CD cord-333672-ef53l283 113 36 , , , cord-333672-ef53l283 113 37 54 54 CD cord-333672-ef53l283 113 38 ) ) -RRB- cord-333672-ef53l283 113 39 . . . cord-333672-ef53l283 114 1 However however RB cord-333672-ef53l283 114 2 , , , cord-333672-ef53l283 114 3 controlled control VBN cord-333672-ef53l283 114 4 studies study NNS cord-333672-ef53l283 114 5 have have VBP cord-333672-ef53l283 114 6 not not RB cord-333672-ef53l283 114 7 shown show VBN cord-333672-ef53l283 114 8 large large JJ cord-333672-ef53l283 114 9 effects effect NNS cord-333672-ef53l283 114 10 of of IN cord-333672-ef53l283 114 11 skipping skip VBG cord-333672-ef53l283 114 12 breakfast breakfast NN cord-333672-ef53l283 114 13 on on IN cord-333672-ef53l283 114 14 cardiometabolic cardiometabolic NNP cord-333672-ef53l283 114 15 health health NNP cord-333672-ef53l283 114 16 ( ( -LRB- cord-333672-ef53l283 114 17 55 55 CD cord-333672-ef53l283 114 18 ) ) -RRB- cord-333672-ef53l283 114 19 . . . cord-333672-ef53l283 115 1 For for IN cord-333672-ef53l283 115 2 example example NN cord-333672-ef53l283 115 3 , , , cord-333672-ef53l283 115 4 lean lean JJ cord-333672-ef53l283 115 5 adults adult NNS cord-333672-ef53l283 115 6 who who WP cord-333672-ef53l283 115 7 skipped skip VBD cord-333672-ef53l283 115 8 breakfast breakfast NN cord-333672-ef53l283 115 9 for for IN cord-333672-ef53l283 115 10 6 6 CD cord-333672-ef53l283 115 11 weeks week NNS cord-333672-ef53l283 115 12 inadvertently inadvertently RB cord-333672-ef53l283 115 13 decreased decrease VBD cord-333672-ef53l283 115 14 their -PRON- PRP$ cord-333672-ef53l283 115 15 daily daily JJ cord-333672-ef53l283 115 16 energy energy NN cord-333672-ef53l283 115 17 intakes intake NNS cord-333672-ef53l283 115 18 , , , cord-333672-ef53l283 115 19 but but CC cord-333672-ef53l283 115 20 this this DT cord-333672-ef53l283 115 21 change change NN cord-333672-ef53l283 115 22 was be VBD cord-333672-ef53l283 115 23 compensated compensate VBN cord-333672-ef53l283 115 24 by by IN cord-333672-ef53l283 115 25 reductions reduction NNS cord-333672-ef53l283 115 26 in in IN cord-333672-ef53l283 115 27 physical physical JJ cord-333672-ef53l283 115 28 activity activity NN cord-333672-ef53l283 115 29 energy energy NN cord-333672-ef53l283 115 30 expenditure expenditure NN cord-333672-ef53l283 115 31 , , , cord-333672-ef53l283 115 32 resulting result VBG cord-333672-ef53l283 115 33 in in IN cord-333672-ef53l283 115 34 no no DT cord-333672-ef53l283 115 35 changes change NNS cord-333672-ef53l283 115 36 in in IN cord-333672-ef53l283 115 37 energy energy NN cord-333672-ef53l283 115 38 balance balance NN cord-333672-ef53l283 115 39 or or CC cord-333672-ef53l283 115 40 body body NN cord-333672-ef53l283 115 41 composition composition NN cord-333672-ef53l283 115 42 ( ( -LRB- cord-333672-ef53l283 115 43 56 56 CD cord-333672-ef53l283 115 44 ) ) -RRB- cord-333672-ef53l283 115 45 . . . cord-333672-ef53l283 116 1 Skipping skip VBG cord-333672-ef53l283 116 2 breakfast breakfast NN cord-333672-ef53l283 116 3 did do VBD cord-333672-ef53l283 116 4 not not RB cord-333672-ef53l283 116 5 affect affect VB cord-333672-ef53l283 116 6 most most JJS cord-333672-ef53l283 116 7 measures measure NNS cord-333672-ef53l283 116 8 of of IN cord-333672-ef53l283 116 9 cardiometabolic cardiometabolic JJ cord-333672-ef53l283 116 10 health health NNP cord-333672-ef53l283 116 11 -the -the ADD cord-333672-ef53l283 117 1 only only RB cord-333672-ef53l283 117 2 noteworthy noteworthy JJ cord-333672-ef53l283 117 3 difference difference NN cord-333672-ef53l283 117 4 between between IN cord-333672-ef53l283 117 5 groups group NNS cord-333672-ef53l283 117 6 was be VBD cord-333672-ef53l283 117 7 that that DT cord-333672-ef53l283 117 8 afternoon afternoon NN cord-333672-ef53l283 117 9 glycaemic glycaemic JJ cord-333672-ef53l283 117 10 variability variability NN cord-333672-ef53l283 117 11 was be VBD cord-333672-ef53l283 117 12 higher high JJR cord-333672-ef53l283 117 13 in in IN cord-333672-ef53l283 117 14 adults adult NNS cord-333672-ef53l283 117 15 who who WP cord-333672-ef53l283 117 16 skipped skip VBD cord-333672-ef53l283 117 17 breakfast breakfast NN cord-333672-ef53l283 117 18 . . . cord-333672-ef53l283 118 1 A a DT cord-333672-ef53l283 118 2 subsequent subsequent JJ cord-333672-ef53l283 118 3 study study NN cord-333672-ef53l283 118 4 implemented implement VBD cord-333672-ef53l283 118 5 the the DT cord-333672-ef53l283 118 6 same same JJ cord-333672-ef53l283 118 7 intervention intervention NN cord-333672-ef53l283 118 8 but but CC cord-333672-ef53l283 118 9 only only RB cord-333672-ef53l283 118 10 included include VBD cord-333672-ef53l283 118 11 obese obese JJ cord-333672-ef53l283 118 12 adults adult NNS cord-333672-ef53l283 118 13 ( ( -LRB- cord-333672-ef53l283 118 14 57 57 CD cord-333672-ef53l283 118 15 ) ) -RRB- cord-333672-ef53l283 118 16 . . . cord-333672-ef53l283 119 1 In in IN cord-333672-ef53l283 119 2 this this DT cord-333672-ef53l283 119 3 study study NN cord-333672-ef53l283 119 4 , , , cord-333672-ef53l283 119 5 participants participant NNS cord-333672-ef53l283 119 6 in in IN cord-333672-ef53l283 119 7 the the DT cord-333672-ef53l283 119 8 breakfast breakfast NN cord-333672-ef53l283 119 9 - - HYPH cord-333672-ef53l283 119 10 skipping skip VBG cord-333672-ef53l283 119 11 group group NN cord-333672-ef53l283 119 12 expended expend VBD cord-333672-ef53l283 119 13 less less JJR cord-333672-ef53l283 119 14 energy energy NN cord-333672-ef53l283 119 15 in in IN cord-333672-ef53l283 119 16 the the DT cord-333672-ef53l283 119 17 morning morning NN cord-333672-ef53l283 119 18 , , , cord-333672-ef53l283 119 19 but but CC cord-333672-ef53l283 119 20 they -PRON- PRP cord-333672-ef53l283 119 21 did do VBD cord-333672-ef53l283 119 22 not not RB cord-333672-ef53l283 119 23 burn burn VB cord-333672-ef53l283 119 24 fewer few JJR cord-333672-ef53l283 119 25 calories calorie NNS cord-333672-ef53l283 119 26 over over IN cord-333672-ef53l283 119 27 the the DT cord-333672-ef53l283 119 28 entire entire JJ cord-333672-ef53l283 119 29 day day NN cord-333672-ef53l283 119 30 . . . cord-333672-ef53l283 120 1 Daily daily JJ cord-333672-ef53l283 120 2 energy energy NN cord-333672-ef53l283 120 3 intake intake NN cord-333672-ef53l283 120 4 was be VBD cord-333672-ef53l283 120 5 similar similar JJ cord-333672-ef53l283 120 6 in in IN cord-333672-ef53l283 120 7 breakfast breakfast NN cord-333672-ef53l283 120 8 - - HYPH cord-333672-ef53l283 120 9 skippers skipper NNS cord-333672-ef53l283 120 10 and and CC cord-333672-ef53l283 120 11 breakfast breakfast NN cord-333672-ef53l283 120 12 eaters eater NNS cord-333672-ef53l283 120 13 , , , cord-333672-ef53l283 120 14 and and CC cord-333672-ef53l283 120 15 both both DT cord-333672-ef53l283 120 16 groups group NNS cord-333672-ef53l283 120 17 gained gain VBD cord-333672-ef53l283 120 18 weight weight NN cord-333672-ef53l283 120 19 during during IN cord-333672-ef53l283 120 20 the the DT cord-333672-ef53l283 120 21 study study NN cord-333672-ef53l283 120 22 . . . cord-333672-ef53l283 121 1 People People NNS cord-333672-ef53l283 121 2 who who WP cord-333672-ef53l283 121 3 skipped skip VBD cord-333672-ef53l283 121 4 breakfast breakfast NN cord-333672-ef53l283 121 5 did do VBD cord-333672-ef53l283 121 6 have have VB cord-333672-ef53l283 121 7 higher high JJR cord-333672-ef53l283 121 8 insulinaemic insulinaemic JJ cord-333672-ef53l283 121 9 responses response NNS cord-333672-ef53l283 121 10 to to IN cord-333672-ef53l283 121 11 an an DT cord-333672-ef53l283 121 12 oral oral JJ cord-333672-ef53l283 121 13 glucose glucose NN cord-333672-ef53l283 121 14 tolerance tolerance NN cord-333672-ef53l283 121 15 test test NN cord-333672-ef53l283 121 16 , , , cord-333672-ef53l283 121 17 however however RB cord-333672-ef53l283 121 18 . . . cord-333672-ef53l283 122 1 These these DT cord-333672-ef53l283 122 2 two two CD cord-333672-ef53l283 122 3 rigorous rigorous JJ cord-333672-ef53l283 122 4 studies study NNS cord-333672-ef53l283 122 5 show show VBP cord-333672-ef53l283 122 6 that that IN cord-333672-ef53l283 122 7 skipping skip VBG cord-333672-ef53l283 122 8 breakfast breakfast NN cord-333672-ef53l283 122 9 minimally minimally RB cord-333672-ef53l283 122 10 affects affect VBZ cord-333672-ef53l283 122 11 energy energy NN cord-333672-ef53l283 122 12 balance balance NN cord-333672-ef53l283 122 13 but but CC cord-333672-ef53l283 122 14 may may MD cord-333672-ef53l283 122 15 negatively negatively RB cord-333672-ef53l283 122 16 affect affect VB cord-333672-ef53l283 122 17 glycaemic glycaemic JJ cord-333672-ef53l283 122 18 regulation regulation NN cord-333672-ef53l283 122 19 and and CC cord-333672-ef53l283 122 20 some some DT cord-333672-ef53l283 122 21 of of IN cord-333672-ef53l283 122 22 its -PRON- PRP$ cord-333672-ef53l283 122 23 determinants determinant NNS cord-333672-ef53l283 122 24 . . . cord-333672-ef53l283 123 1 As as IN cord-333672-ef53l283 123 2 sleep sleep NN cord-333672-ef53l283 123 3 timing timing NN cord-333672-ef53l283 123 4 did do VBD cord-333672-ef53l283 123 5 not not RB cord-333672-ef53l283 123 6 differ differ VB cord-333672-ef53l283 123 7 between between IN cord-333672-ef53l283 123 8 groups group NNS cord-333672-ef53l283 123 9 , , , cord-333672-ef53l283 123 10 breakfast breakfast NN cord-333672-ef53l283 123 11 skipping skipping NN cord-333672-ef53l283 123 12 led lead VBD cord-333672-ef53l283 123 13 to to IN cord-333672-ef53l283 123 14 a a DT cord-333672-ef53l283 123 15 form form NN cord-333672-ef53l283 123 16 of of IN cord-333672-ef53l283 123 17 late late JJ cord-333672-ef53l283 123 18 TRE TRE NNP cord-333672-ef53l283 123 19 , , , cord-333672-ef53l283 123 20 so so RB cord-333672-ef53l283 123 21 these these DT cord-333672-ef53l283 123 22 studies study NNS cord-333672-ef53l283 123 23 imply imply VBP cord-333672-ef53l283 123 24 that that IN cord-333672-ef53l283 123 25 late late JJ cord-333672-ef53l283 123 26 TRE TRE NNP cord-333672-ef53l283 123 27 may may MD cord-333672-ef53l283 123 28 not not RB cord-333672-ef53l283 123 29 be be VB cord-333672-ef53l283 123 30 optimal optimal JJ cord-333672-ef53l283 123 31 for for IN cord-333672-ef53l283 123 32 some some DT cord-333672-ef53l283 123 33 aspects aspect NNS cord-333672-ef53l283 123 34 of of IN cord-333672-ef53l283 123 35 cardiometabolic cardiometabolic JJ cord-333672-ef53l283 123 36 health health NN cord-333672-ef53l283 123 37 . . . cord-333672-ef53l283 124 1 Skipping skip VBG cord-333672-ef53l283 124 2 breakfast breakfast NN cord-333672-ef53l283 124 3 imposes impose VBZ cord-333672-ef53l283 124 4 a a DT cord-333672-ef53l283 124 5 relatively relatively RB cord-333672-ef53l283 124 6 late late JJ cord-333672-ef53l283 124 7 caloric caloric JJ cord-333672-ef53l283 124 8 period period NN cord-333672-ef53l283 124 9 , , , cord-333672-ef53l283 124 10 and and CC cord-333672-ef53l283 124 11 an an DT cord-333672-ef53l283 124 12 alternative alternative NN cord-333672-ef53l283 124 13 is be VBZ cord-333672-ef53l283 124 14 to to TO cord-333672-ef53l283 124 15 shorten shorten VB cord-333672-ef53l283 124 16 the the DT cord-333672-ef53l283 124 17 caloric caloric JJ cord-333672-ef53l283 124 18 period period NN cord-333672-ef53l283 124 19 by by IN cord-333672-ef53l283 124 20 way way NN cord-333672-ef53l283 124 21 of of IN cord-333672-ef53l283 124 22 skipping skip VBG cord-333672-ef53l283 124 23 dinner dinner NN cord-333672-ef53l283 124 24 or or CC cord-333672-ef53l283 124 25 having have VBG cord-333672-ef53l283 124 26 an an DT cord-333672-ef53l283 124 27 early early JJ cord-333672-ef53l283 124 28 dinner dinner NN cord-333672-ef53l283 124 29 . . . cord-333672-ef53l283 125 1 Several several JJ cord-333672-ef53l283 125 2 recent recent JJ cord-333672-ef53l283 125 3 carefully carefully RB cord-333672-ef53l283 125 4 controlled control VBN cord-333672-ef53l283 125 5 experiments experiment NNS cord-333672-ef53l283 125 6 have have VBP cord-333672-ef53l283 125 7 shown show VBN cord-333672-ef53l283 125 8 that that IN cord-333672-ef53l283 125 9 such such JJ cord-333672-ef53l283 125 10 early early JJ cord-333672-ef53l283 125 11 TRE TRE NNP cord-333672-ef53l283 125 12 may may MD cord-333672-ef53l283 125 13 exert exert VB cord-333672-ef53l283 125 14 numerous numerous JJ cord-333672-ef53l283 125 15 positive positive JJ cord-333672-ef53l283 125 16 effects effect NNS cord-333672-ef53l283 125 17 on on IN cord-333672-ef53l283 125 18 health health NN cord-333672-ef53l283 125 19 . . . cord-333672-ef53l283 126 1 The the DT cord-333672-ef53l283 126 2 first first JJ cord-333672-ef53l283 126 3 of of IN cord-333672-ef53l283 126 4 these these DT cord-333672-ef53l283 126 5 experiments experiment NNS cord-333672-ef53l283 126 6 reported report VBD cord-333672-ef53l283 126 7 that that IN cord-333672-ef53l283 126 8 compared compare VBN cord-333672-ef53l283 126 9 with with IN cord-333672-ef53l283 126 10 a a DT cord-333672-ef53l283 126 11 ∼ ∼ NNP cord-333672-ef53l283 126 12 12-h 12-h CD cord-333672-ef53l283 126 13 daily daily JJ cord-333672-ef53l283 126 14 caloric caloric JJ cord-333672-ef53l283 126 15 period period NN cord-333672-ef53l283 126 16 for for IN cord-333672-ef53l283 126 17 5 5 CD cord-333672-ef53l283 126 18 weeks week NNS cord-333672-ef53l283 126 19 , , , cord-333672-ef53l283 126 20 5 5 CD cord-333672-ef53l283 126 21 weeks week NNS cord-333672-ef53l283 126 22 of of IN cord-333672-ef53l283 126 23 early early JJ cord-333672-ef53l283 126 24 TRE TRE NNP cord-333672-ef53l283 126 25 ( ( -LRB- cord-333672-ef53l283 126 26 ∼ ∼ NNP cord-333672-ef53l283 126 27 6-h 6-h CD cord-333672-ef53l283 126 28 daily daily JJ cord-333672-ef53l283 126 29 caloric caloric JJ cord-333672-ef53l283 126 30 period period NN cord-333672-ef53l283 126 31 , , , cord-333672-ef53l283 126 32 finished finish VBN cord-333672-ef53l283 126 33 by by IN cord-333672-ef53l283 126 34 15:00 15:00 CD cord-333672-ef53l283 126 35 ) ) -RRB- cord-333672-ef53l283 126 36 improved improve VBN cord-333672-ef53l283 126 37 insulin insulin NN cord-333672-ef53l283 126 38 sensitivity sensitivity NN cord-333672-ef53l283 126 39 , , , cord-333672-ef53l283 126 40 blood blood NN cord-333672-ef53l283 126 41 pressure pressure NN cord-333672-ef53l283 126 42 , , , cord-333672-ef53l283 126 43 appetite appetite NN cord-333672-ef53l283 126 44 regulation regulation NN cord-333672-ef53l283 126 45 , , , cord-333672-ef53l283 126 46 and and CC cord-333672-ef53l283 126 47 a a DT cord-333672-ef53l283 126 48 marker marker NN cord-333672-ef53l283 126 49 of of IN cord-333672-ef53l283 126 50 oxidative oxidative JJ cord-333672-ef53l283 126 51 stress stress NN cord-333672-ef53l283 126 52 in in IN cord-333672-ef53l283 126 53 men man NNS cord-333672-ef53l283 126 54 who who WP cord-333672-ef53l283 126 55 have have VBP cord-333672-ef53l283 126 56 prediabetes prediabete NNS cord-333672-ef53l283 126 57 ( ( -LRB- cord-333672-ef53l283 126 58 58 58 CD cord-333672-ef53l283 126 59 ) ) -RRB- cord-333672-ef53l283 126 60 . . . cord-333672-ef53l283 127 1 The the DT cord-333672-ef53l283 127 2 same same JJ cord-333672-ef53l283 127 3 group group NN cord-333672-ef53l283 127 4 of of IN cord-333672-ef53l283 127 5 scientists scientist NNS cord-333672-ef53l283 127 6 recently recently RB cord-333672-ef53l283 127 7 reported report VBD cord-333672-ef53l283 127 8 that that IN cord-333672-ef53l283 127 9 in in IN cord-333672-ef53l283 127 10 overweight overweight JJ cord-333672-ef53l283 127 11 adults adult NNS cord-333672-ef53l283 127 12 , , , cord-333672-ef53l283 127 13 just just RB cord-333672-ef53l283 127 14 4 4 CD cord-333672-ef53l283 127 15 days day NNS cord-333672-ef53l283 127 16 of of IN cord-333672-ef53l283 127 17 early early JJ cord-333672-ef53l283 127 18 TRE TRE NNP cord-333672-ef53l283 127 19 reduced reduce VBN cord-333672-ef53l283 127 20 mean mean NN cord-333672-ef53l283 127 21 24-h 24-h JJ cord-333672-ef53l283 127 22 blood blood NN cord-333672-ef53l283 127 23 glucose glucose NN cord-333672-ef53l283 127 24 levels level NNS cord-333672-ef53l283 127 25 and and CC cord-333672-ef53l283 127 26 improved improve VBN cord-333672-ef53l283 127 27 metabolic metabolic JJ cord-333672-ef53l283 127 28 flexibility flexibility NN cord-333672-ef53l283 127 29 , , , cord-333672-ef53l283 127 30 among among IN cord-333672-ef53l283 127 31 other other JJ cord-333672-ef53l283 127 32 benefits benefit NNS cord-333672-ef53l283 127 33 ( ( -LRB- cord-333672-ef53l283 127 34 59 59 CD cord-333672-ef53l283 127 35 , , , cord-333672-ef53l283 127 36 60 60 CD cord-333672-ef53l283 127 37 ) ) -RRB- cord-333672-ef53l283 127 38 . . . cord-333672-ef53l283 128 1 These these DT cord-333672-ef53l283 128 2 experiments experiment NNS cord-333672-ef53l283 128 3 did do VBD cord-333672-ef53l283 128 4 not not RB cord-333672-ef53l283 128 5 compare compare VB cord-333672-ef53l283 128 6 early early JJ cord-333672-ef53l283 128 7 TRE TRE NNP cord-333672-ef53l283 128 8 to to TO cord-333672-ef53l283 128 9 later later RB cord-333672-ef53l283 128 10 TRE TRE NNP cord-333672-ef53l283 128 11 while while IN cord-333672-ef53l283 128 12 keeping keep VBG cord-333672-ef53l283 128 13 the the DT cord-333672-ef53l283 128 14 caloric caloric JJ cord-333672-ef53l283 128 15 period period NN cord-333672-ef53l283 128 16 fixed fix VBN cord-333672-ef53l283 128 17 , , , cord-333672-ef53l283 128 18 however however RB cord-333672-ef53l283 128 19 , , , cord-333672-ef53l283 128 20 and and CC cord-333672-ef53l283 128 21 to to IN cord-333672-ef53l283 128 22 our -PRON- PRP$ cord-333672-ef53l283 128 23 knowledge knowledge NN cord-333672-ef53l283 128 24 , , , cord-333672-ef53l283 128 25 only only RB cord-333672-ef53l283 128 26 one one CD cord-333672-ef53l283 128 27 study study NN cord-333672-ef53l283 128 28 has have VBZ cord-333672-ef53l283 128 29 done do VBN cord-333672-ef53l283 128 30 this this DT cord-333672-ef53l283 128 31 to to IN cord-333672-ef53l283 128 32 date date NN cord-333672-ef53l283 128 33 ( ( -LRB- cord-333672-ef53l283 128 34 61 61 CD cord-333672-ef53l283 128 35 ) ) -RRB- cord-333672-ef53l283 128 36 . . . cord-333672-ef53l283 129 1 The the DT cord-333672-ef53l283 129 2 study study NN cord-333672-ef53l283 129 3 in in IN cord-333672-ef53l283 129 4 question question NN cord-333672-ef53l283 129 5 showed show VBD cord-333672-ef53l283 129 6 that that IN cord-333672-ef53l283 129 7 7 7 CD cord-333672-ef53l283 129 8 days day NNS cord-333672-ef53l283 129 9 of of IN cord-333672-ef53l283 129 10 both both CC cord-333672-ef53l283 129 11 early early JJ cord-333672-ef53l283 129 12 ( ( -LRB- cord-333672-ef53l283 129 13 08:00 08:00 CD cord-333672-ef53l283 129 14 to to IN cord-333672-ef53l283 129 15 17:00 17:00 CD cord-333672-ef53l283 129 16 ) ) -RRB- cord-333672-ef53l283 129 17 and and CC cord-333672-ef53l283 129 18 late late JJ cord-333672-ef53l283 129 19 ( ( -LRB- cord-333672-ef53l283 129 20 12:00 12:00 CD cord-333672-ef53l283 129 21 to to IN cord-333672-ef53l283 129 22 21:00 21:00 CD cord-333672-ef53l283 129 23 ) ) -RRB- cord-333672-ef53l283 129 24 TRE TRE NNP cord-333672-ef53l283 129 25 improved improve VBD cord-333672-ef53l283 129 26 oral oral JJ cord-333672-ef53l283 129 27 glucose glucose NN cord-333672-ef53l283 129 28 tolerance tolerance NN cord-333672-ef53l283 129 29 in in IN cord-333672-ef53l283 129 30 men man NNS cord-333672-ef53l283 129 31 at at IN cord-333672-ef53l283 129 32 high high JJ cord-333672-ef53l283 129 33 risk risk NN cord-333672-ef53l283 129 34 of of IN cord-333672-ef53l283 129 35 developing develop VBG cord-333672-ef53l283 129 36 type type NN cord-333672-ef53l283 129 37 - - HYPH cord-333672-ef53l283 129 38 two two CD cord-333672-ef53l283 129 39 diabetes diabete NNS cord-333672-ef53l283 129 40 , , , cord-333672-ef53l283 129 41 although although IN cord-333672-ef53l283 129 42 only only RB cord-333672-ef53l283 129 43 early early JJ cord-333672-ef53l283 129 44 TRE TRE NNP cord-333672-ef53l283 129 45 lowered lower VBD cord-333672-ef53l283 129 46 fasting fast VBG cord-333672-ef53l283 129 47 glucose glucose NN cord-333672-ef53l283 129 48 , , , cord-333672-ef53l283 129 49 suggest suggest VBP cord-333672-ef53l283 129 50 a a DT cord-333672-ef53l283 129 51 small small JJ cord-333672-ef53l283 129 52 advantage advantage NN cord-333672-ef53l283 129 53 of of IN cord-333672-ef53l283 129 54 early early JJ cord-333672-ef53l283 129 55 TRE TRE NNP cord-333672-ef53l283 129 56 ( ( -LRB- cord-333672-ef53l283 129 57 61 61 CD cord-333672-ef53l283 129 58 ) ) -RRB- cord-333672-ef53l283 129 59 . . . cord-333672-ef53l283 130 1 While while IN cord-333672-ef53l283 130 2 this this DT cord-333672-ef53l283 130 3 hypothesis hypothesis NN cord-333672-ef53l283 130 4 needs need VBZ cord-333672-ef53l283 130 5 careful careful JJ cord-333672-ef53l283 130 6 testing testing NN cord-333672-ef53l283 130 7 , , , cord-333672-ef53l283 130 8 we -PRON- PRP cord-333672-ef53l283 130 9 believe believe VBP cord-333672-ef53l283 130 10 that that IN cord-333672-ef53l283 130 11 early early JJ cord-333672-ef53l283 130 12 TRE TRE NNP cord-333672-ef53l283 130 13 may may MD cord-333672-ef53l283 130 14 also also RB cord-333672-ef53l283 130 15 enhance enhance VB cord-333672-ef53l283 130 16 diet diet NN cord-333672-ef53l283 130 17 composition composition NN cord-333672-ef53l283 130 18 by by IN cord-333672-ef53l283 130 19 reducing reduce VBG cord-333672-ef53l283 130 20 intakes intake NNS cord-333672-ef53l283 130 21 of of IN cord-333672-ef53l283 130 22 foods food NNS cord-333672-ef53l283 130 23 and and CC cord-333672-ef53l283 130 24 drinks drink NNS cord-333672-ef53l283 130 25 commonly commonly RB cord-333672-ef53l283 130 26 consumed consume VBN cord-333672-ef53l283 130 27 in in IN cord-333672-ef53l283 130 28 the the DT cord-333672-ef53l283 130 29 evening evening NN cord-333672-ef53l283 130 30 , , , cord-333672-ef53l283 130 31 such such JJ cord-333672-ef53l283 130 32 as as IN cord-333672-ef53l283 130 33 processed process VBN cord-333672-ef53l283 130 34 snacks snack NNS cord-333672-ef53l283 130 35 and and CC cord-333672-ef53l283 130 36 alcohol alcohol NN cord-333672-ef53l283 130 37 . . . cord-333672-ef53l283 131 1 Together together RB cord-333672-ef53l283 131 2 , , , cord-333672-ef53l283 131 3 these these DT cord-333672-ef53l283 131 4 studies study NNS cord-333672-ef53l283 131 5 support support VBP cord-333672-ef53l283 131 6 the the DT cord-333672-ef53l283 131 7 superiority superiority NN cord-333672-ef53l283 131 8 of of IN cord-333672-ef53l283 131 9 relatively relatively RB cord-333672-ef53l283 131 10 early early JJ cord-333672-ef53l283 131 11 TRE tre NN cord-333672-ef53l283 131 12 in in IN cord-333672-ef53l283 131 13 adults adult NNS cord-333672-ef53l283 131 14 who who WP cord-333672-ef53l283 131 15 have have VBP cord-333672-ef53l283 131 16 poor poor JJ cord-333672-ef53l283 131 17 cardiometabolic cardiometabolic JJ cord-333672-ef53l283 131 18 health health NN cord-333672-ef53l283 131 19 . . . cord-333672-ef53l283 132 1 However however RB cord-333672-ef53l283 132 2 , , , cord-333672-ef53l283 132 3 non non JJ cord-333672-ef53l283 132 4 - - JJ cord-333672-ef53l283 132 5 self self JJ cord-333672-ef53l283 132 6 - - HYPH cord-333672-ef53l283 132 7 selected select VBN cord-333672-ef53l283 132 8 TRE TRE NNP cord-333672-ef53l283 132 9 schedules schedule NNS cord-333672-ef53l283 132 10 may may MD cord-333672-ef53l283 132 11 interfere interfere VB cord-333672-ef53l283 132 12 with with IN cord-333672-ef53l283 132 13 some some DT cord-333672-ef53l283 132 14 social social JJ cord-333672-ef53l283 132 15 activities activity NNS cord-333672-ef53l283 132 16 and and CC cord-333672-ef53l283 132 17 be be VB cord-333672-ef53l283 132 18 difficult difficult JJ cord-333672-ef53l283 132 19 to to TO cord-333672-ef53l283 132 20 adhere adhere VB cord-333672-ef53l283 132 21 to to IN cord-333672-ef53l283 132 22 in in IN cord-333672-ef53l283 132 23 the the DT cord-333672-ef53l283 132 24 context context NN cord-333672-ef53l283 132 25 of of IN cord-333672-ef53l283 132 26 work work NN cord-333672-ef53l283 132 27 schedules schedule NNS cord-333672-ef53l283 132 28 and and CC cord-333672-ef53l283 132 29 family family NN cord-333672-ef53l283 132 30 commitments commitment NNS cord-333672-ef53l283 132 31 ( ( -LRB- cord-333672-ef53l283 132 32 62 62 CD cord-333672-ef53l283 132 33 , , , cord-333672-ef53l283 132 34 63 63 CD cord-333672-ef53l283 132 35 ) ) -RRB- cord-333672-ef53l283 132 36 . . . cord-333672-ef53l283 133 1 Letting let VBG cord-333672-ef53l283 133 2 people people NNS cord-333672-ef53l283 133 3 self self NN cord-333672-ef53l283 133 4 - - HYPH cord-333672-ef53l283 133 5 select select VBP cord-333672-ef53l283 133 6 their -PRON- PRP$ cord-333672-ef53l283 133 7 TRE TRE NNP cord-333672-ef53l283 133 8 periods period NNS cord-333672-ef53l283 133 9 helps help VBZ cord-333672-ef53l283 133 10 mitigate mitigate VB cord-333672-ef53l283 133 11 these these DT cord-333672-ef53l283 133 12 undesirable undesirable JJ cord-333672-ef53l283 133 13 consequences consequence NNS cord-333672-ef53l283 133 14 . . . cord-333672-ef53l283 134 1 Indeed indeed RB cord-333672-ef53l283 134 2 , , , cord-333672-ef53l283 134 3 12 12 CD cord-333672-ef53l283 134 4 weeks week NNS cord-333672-ef53l283 134 5 of of IN cord-333672-ef53l283 134 6 self self NN cord-333672-ef53l283 134 7 - - HYPH cord-333672-ef53l283 134 8 selected select VBN cord-333672-ef53l283 134 9 TRE TRE NNP cord-333672-ef53l283 134 10 minimised minimise VBD cord-333672-ef53l283 134 11 these these DT cord-333672-ef53l283 134 12 issues issue NNS cord-333672-ef53l283 134 13 in in IN cord-333672-ef53l283 134 14 adults adult NNS cord-333672-ef53l283 134 15 with with IN cord-333672-ef53l283 134 16 metabolic metabolic JJ cord-333672-ef53l283 134 17 syndrome syndrome NN cord-333672-ef53l283 134 18 , , , cord-333672-ef53l283 134 19 also also RB cord-333672-ef53l283 134 20 reducing reduce VBG cord-333672-ef53l283 134 21 daily daily JJ cord-333672-ef53l283 134 22 energy energy NN cord-333672-ef53l283 134 23 intake intake NN cord-333672-ef53l283 134 24 and and CC cord-333672-ef53l283 134 25 potently potently RB cord-333672-ef53l283 134 26 improving improve VBG cord-333672-ef53l283 134 27 numerous numerous JJ cord-333672-ef53l283 134 28 aspects aspect NNS cord-333672-ef53l283 134 29 of of IN cord-333672-ef53l283 134 30 cardiometabolic cardiometabolic JJ cord-333672-ef53l283 134 31 health health NN cord-333672-ef53l283 134 32 including include VBG cord-333672-ef53l283 134 33 bodyweight bodyweight NN cord-333672-ef53l283 134 34 , , , cord-333672-ef53l283 134 35 waist waist NN cord-333672-ef53l283 134 36 circumference circumference NN cord-333672-ef53l283 134 37 , , , cord-333672-ef53l283 134 38 and and CC cord-333672-ef53l283 134 39 blood blood NN cord-333672-ef53l283 134 40 pressure pressure NN cord-333672-ef53l283 134 41 ( ( -LRB- cord-333672-ef53l283 134 42 64 64 CD cord-333672-ef53l283 134 43 ) ) -RRB- cord-333672-ef53l283 134 44 . . . cord-333672-ef53l283 135 1 Moreover moreover RB cord-333672-ef53l283 135 2 , , , cord-333672-ef53l283 135 3 TRE TRE NNP cord-333672-ef53l283 135 4 led lead VBD cord-333672-ef53l283 135 5 to to IN cord-333672-ef53l283 135 6 more more RBR cord-333672-ef53l283 135 7 regular regular JJ cord-333672-ef53l283 135 8 diet diet NN cord-333672-ef53l283 135 9 timing timing NN cord-333672-ef53l283 135 10 , , , cord-333672-ef53l283 135 11 which which WDT cord-333672-ef53l283 135 12 may may MD cord-333672-ef53l283 135 13 independently independently RB cord-333672-ef53l283 135 14 be be VB cord-333672-ef53l283 135 15 beneficial beneficial JJ cord-333672-ef53l283 135 16 for for IN cord-333672-ef53l283 135 17 cardiometabolic cardiometabolic JJ cord-333672-ef53l283 135 18 health health NN cord-333672-ef53l283 135 19 ( ( -LRB- cord-333672-ef53l283 135 20 65 65 CD cord-333672-ef53l283 135 21 ) ) -RRB- cord-333672-ef53l283 135 22 . . . cord-333672-ef53l283 136 1 Interestingly interestingly RB cord-333672-ef53l283 136 2 , , , cord-333672-ef53l283 136 3 TRE TRE NNP cord-333672-ef53l283 136 4 also also RB cord-333672-ef53l283 136 5 improved improve VBD cord-333672-ef53l283 136 6 sleep sleep NN cord-333672-ef53l283 136 7 timing timing NN cord-333672-ef53l283 136 8 regularity regularity NN cord-333672-ef53l283 136 9 and and CC cord-333672-ef53l283 136 10 increased increase VBD cord-333672-ef53l283 136 11 how how WRB cord-333672-ef53l283 136 12 often often RB cord-333672-ef53l283 136 13 participants participant NNS cord-333672-ef53l283 136 14 selfreported selfreporte VBD cord-333672-ef53l283 136 15 restorative restorative JJ cord-333672-ef53l283 136 16 sleep sleep NN cord-333672-ef53l283 136 17 . . . cord-333672-ef53l283 137 1 However however RB cord-333672-ef53l283 137 2 , , , cord-333672-ef53l283 137 3 this this DT cord-333672-ef53l283 137 4 study study NN cord-333672-ef53l283 137 5 was be VBD cord-333672-ef53l283 137 6 an an DT cord-333672-ef53l283 137 7 unblinded unblinded JJ cord-333672-ef53l283 137 8 , , , cord-333672-ef53l283 137 9 single single JJ cord-333672-ef53l283 137 10 - - HYPH cord-333672-ef53l283 137 11 arm arm NN cord-333672-ef53l283 137 12 study study NN cord-333672-ef53l283 137 13 with with IN cord-333672-ef53l283 137 14 only only RB cord-333672-ef53l283 137 15 19 19 CD cord-333672-ef53l283 137 16 participants participant NNS cord-333672-ef53l283 137 17 included include VBN cord-333672-ef53l283 137 18 in in IN cord-333672-ef53l283 137 19 the the DT cord-333672-ef53l283 137 20 data data NN cord-333672-ef53l283 137 21 analysis analysis NN cord-333672-ef53l283 137 22 ( ( -LRB- cord-333672-ef53l283 137 23 64 64 CD cord-333672-ef53l283 137 24 ) ) -RRB- cord-333672-ef53l283 137 25 . . . cord-333672-ef53l283 138 1 Based base VBN cord-333672-ef53l283 138 2 on on IN cord-333672-ef53l283 138 3 existing exist VBG cord-333672-ef53l283 138 4 studies study NNS cord-333672-ef53l283 138 5 , , , cord-333672-ef53l283 138 6 TRE TRE NNP cord-333672-ef53l283 138 7 appears appear VBZ cord-333672-ef53l283 138 8 to to TO cord-333672-ef53l283 138 9 be be VB cord-333672-ef53l283 138 10 a a DT cord-333672-ef53l283 138 11 safe safe JJ cord-333672-ef53l283 138 12 strategy strategy NN cord-333672-ef53l283 138 13 that that WDT cord-333672-ef53l283 138 14 is be VBZ cord-333672-ef53l283 138 15 likely likely JJ cord-333672-ef53l283 138 16 to to TO cord-333672-ef53l283 138 17 reduce reduce VB cord-333672-ef53l283 138 18 energy energy NN cord-333672-ef53l283 138 19 intake intake NN cord-333672-ef53l283 138 20 , , , cord-333672-ef53l283 138 21 which which WDT cord-333672-ef53l283 138 22 would would MD cord-333672-ef53l283 138 23 be be VB cord-333672-ef53l283 138 24 especially especially RB cord-333672-ef53l283 138 25 beneficial beneficial JJ cord-333672-ef53l283 138 26 for for IN cord-333672-ef53l283 138 27 people people NNS cord-333672-ef53l283 138 28 who who WP cord-333672-ef53l283 138 29 have have VBP cord-333672-ef53l283 138 30 unavoidably unavoidably RB cord-333672-ef53l283 138 31 sedentary sedentary JJ cord-333672-ef53l283 138 32 lifestyles lifestyle NNS cord-333672-ef53l283 138 33 . . . cord-333672-ef53l283 139 1 We -PRON- PRP cord-333672-ef53l283 139 2 hypothesise hypothesise VBP cord-333672-ef53l283 139 3 that that IN cord-333672-ef53l283 139 4 fixing fix VBG cord-333672-ef53l283 139 5 the the DT cord-333672-ef53l283 139 6 timing timing NN cord-333672-ef53l283 139 7 of of IN cord-333672-ef53l283 139 8 each each DT cord-333672-ef53l283 139 9 worker worker NN cord-333672-ef53l283 139 10 's 's POS cord-333672-ef53l283 139 11 caloric caloric JJ cord-333672-ef53l283 139 12 period period NN cord-333672-ef53l283 139 13 within within IN cord-333672-ef53l283 139 14 regular regular JJ cord-333672-ef53l283 139 15 hours hour NNS cord-333672-ef53l283 139 16 each each DT cord-333672-ef53l283 139 17 day day NN cord-333672-ef53l283 139 18 supports support VBZ cord-333672-ef53l283 139 19 metabolic metabolic JJ cord-333672-ef53l283 139 20 health health NN cord-333672-ef53l283 139 21 , , , cord-333672-ef53l283 139 22 and and CC cord-333672-ef53l283 139 23 it -PRON- PRP cord-333672-ef53l283 139 24 is be VBZ cord-333672-ef53l283 139 25 plausible plausible JJ cord-333672-ef53l283 139 26 that that IN cord-333672-ef53l283 139 27 this this DT cord-333672-ef53l283 139 28 may may MD cord-333672-ef53l283 139 29 be be VB cord-333672-ef53l283 139 30 especially especially RB cord-333672-ef53l283 139 31 important important JJ cord-333672-ef53l283 139 32 in in IN cord-333672-ef53l283 139 33 workers worker NNS cord-333672-ef53l283 139 34 who who WP cord-333672-ef53l283 139 35 are be VBP cord-333672-ef53l283 139 36 subject subject JJ cord-333672-ef53l283 139 37 to to IN cord-333672-ef53l283 139 38 unpredictable unpredictable JJ cord-333672-ef53l283 139 39 changes change NNS cord-333672-ef53l283 139 40 in in IN cord-333672-ef53l283 139 41 zeitgebers zeitgebers NNP cord-333672-ef53l283 139 42 such such JJ cord-333672-ef53l283 139 43 as as IN cord-333672-ef53l283 139 44 LD LD NNP cord-333672-ef53l283 139 45 cycles cycle NNS cord-333672-ef53l283 139 46 ( ( -LRB- cord-333672-ef53l283 139 47 e.g. e.g. RB cord-333672-ef53l283 139 48 , , , cord-333672-ef53l283 139 49 emergency emergency NN cord-333672-ef53l283 139 50 service service NN cord-333672-ef53l283 139 51 workers worker NNS cord-333672-ef53l283 139 52 ) ) -RRB- cord-333672-ef53l283 139 53 . . . cord-333672-ef53l283 140 1 We -PRON- PRP cord-333672-ef53l283 140 2 further further RB cord-333672-ef53l283 140 3 speculate speculate VBP cord-333672-ef53l283 140 4 that that IN cord-333672-ef53l283 140 5 each each DT cord-333672-ef53l283 140 6 worker worker NN cord-333672-ef53l283 140 7 's 's POS cord-333672-ef53l283 140 8 biological biological JJ cord-333672-ef53l283 140 9 daytime daytime NN cord-333672-ef53l283 140 10 is be VBZ cord-333672-ef53l283 140 11 the the DT cord-333672-ef53l283 140 12 optimal optimal JJ cord-333672-ef53l283 140 13 time time NN cord-333672-ef53l283 140 14 at at IN cord-333672-ef53l283 140 15 which which WDT cord-333672-ef53l283 140 16 to to TO cord-333672-ef53l283 140 17 fix fix VB cord-333672-ef53l283 140 18 the the DT cord-333672-ef53l283 140 19 individual individual NN cord-333672-ef53l283 140 20 's 's POS cord-333672-ef53l283 140 21 caloric caloric JJ cord-333672-ef53l283 140 22 period period NN cord-333672-ef53l283 140 23 , , , cord-333672-ef53l283 140 24 but but CC cord-333672-ef53l283 140 25 self self NN cord-333672-ef53l283 140 26 - - HYPH cord-333672-ef53l283 140 27 selection selection NN cord-333672-ef53l283 140 28 of of IN cord-333672-ef53l283 140 29 TRE TRE NNP cord-333672-ef53l283 140 30 schedules schedule NNS cord-333672-ef53l283 140 31 will will MD cord-333672-ef53l283 140 32 help help VB cord-333672-ef53l283 140 33 people people NNS cord-333672-ef53l283 140 34 adhere adhere VB cord-333672-ef53l283 140 35 to to IN cord-333672-ef53l283 140 36 TRE TRE NNP cord-333672-ef53l283 140 37 and and CC cord-333672-ef53l283 140 38 avoid avoid VB cord-333672-ef53l283 140 39 undesirable undesirable JJ cord-333672-ef53l283 140 40 effects effect NNS cord-333672-ef53l283 140 41 on on IN cord-333672-ef53l283 140 42 social social JJ cord-333672-ef53l283 140 43 and and CC cord-333672-ef53l283 140 44 family family NN cord-333672-ef53l283 140 45 life life NN cord-333672-ef53l283 140 46 . . . cord-333672-ef53l283 141 1 This this DT cord-333672-ef53l283 141 2 said say VBD cord-333672-ef53l283 141 3 , , , cord-333672-ef53l283 141 4 scheduling schedule VBG cord-333672-ef53l283 141 5 TRE TRE NNP cord-333672-ef53l283 141 6 as as RB cord-333672-ef53l283 141 7 early early RB cord-333672-ef53l283 141 8 as as IN cord-333672-ef53l283 141 9 is be VBZ cord-333672-ef53l283 141 10 practical practical JJ cord-333672-ef53l283 141 11 may may MD cord-333672-ef53l283 141 12 maximise maximise VB cord-333672-ef53l283 141 13 the the DT cord-333672-ef53l283 141 14 beneficial beneficial JJ cord-333672-ef53l283 141 15 cardiometabolic cardiometabolic JJ cord-333672-ef53l283 141 16 effects effect NNS cord-333672-ef53l283 141 17 of of IN cord-333672-ef53l283 141 18 TRE TRE NNP cord-333672-ef53l283 141 19 . . . cord-333672-ef53l283 142 1 While while IN cord-333672-ef53l283 142 2 a a DT cord-333672-ef53l283 142 3 detailed detailed JJ cord-333672-ef53l283 142 4 discussion discussion NN cord-333672-ef53l283 142 5 of of IN cord-333672-ef53l283 142 6 this this DT cord-333672-ef53l283 142 7 subject subject NN cord-333672-ef53l283 142 8 is be VBZ cord-333672-ef53l283 142 9 beyond beyond IN cord-333672-ef53l283 142 10 the the DT cord-333672-ef53l283 142 11 scope scope NN cord-333672-ef53l283 142 12 of of IN cord-333672-ef53l283 142 13 this this DT cord-333672-ef53l283 142 14 review review NN cord-333672-ef53l283 142 15 , , , cord-333672-ef53l283 142 16 several several JJ cord-333672-ef53l283 142 17 recent recent JJ cord-333672-ef53l283 142 18 controlled control VBN cord-333672-ef53l283 142 19 studies study NNS cord-333672-ef53l283 142 20 have have VBP cord-333672-ef53l283 142 21 shown show VBN cord-333672-ef53l283 142 22 that that IN cord-333672-ef53l283 142 23 when when WRB cord-333672-ef53l283 142 24 daily daily JJ cord-333672-ef53l283 142 25 energy energy NN cord-333672-ef53l283 142 26 intake intake NN cord-333672-ef53l283 142 27 is be VBZ cord-333672-ef53l283 142 28 fixed fix VBN cord-333672-ef53l283 142 29 , , , cord-333672-ef53l283 142 30 the the DT cord-333672-ef53l283 142 31 distributions distribution NNS cord-333672-ef53l283 142 32 of of IN cord-333672-ef53l283 142 33 energy energy NN cord-333672-ef53l283 142 34 and and CC cord-333672-ef53l283 142 35 macronutrient macronutrient NN cord-333672-ef53l283 142 36 intakes intake NNS cord-333672-ef53l283 142 37 within within IN cord-333672-ef53l283 142 38 the the DT cord-333672-ef53l283 142 39 caloric caloric JJ cord-333672-ef53l283 142 40 period period NN cord-333672-ef53l283 142 41 strongly strongly RB cord-333672-ef53l283 142 42 influence influence VBP cord-333672-ef53l283 142 43 cardiometabolic cardiometabolic JJ cord-333672-ef53l283 142 44 health health NN cord-333672-ef53l283 142 45 . . . cord-333672-ef53l283 143 1 For for IN cord-333672-ef53l283 143 2 example example NN cord-333672-ef53l283 143 3 , , , cord-333672-ef53l283 143 4 one one CD cord-333672-ef53l283 143 5 study study NN cord-333672-ef53l283 143 6 divided divide VBD cord-333672-ef53l283 143 7 overweight overweight JJ cord-333672-ef53l283 143 8 and and CC cord-333672-ef53l283 143 9 obese obese JJ cord-333672-ef53l283 143 10 women woman NNS cord-333672-ef53l283 143 11 into into IN cord-333672-ef53l283 143 12 two two CD cord-333672-ef53l283 143 13 groups group NNS cord-333672-ef53l283 143 14 that that WDT cord-333672-ef53l283 143 15 consumed consume VBD cord-333672-ef53l283 143 16 isocaloric isocaloric JJ cord-333672-ef53l283 143 17 weight weight NN cord-333672-ef53l283 143 18 loss loss NN cord-333672-ef53l283 143 19 diets diet NNS cord-333672-ef53l283 143 20 for for IN cord-333672-ef53l283 143 21 12 12 CD cord-333672-ef53l283 143 22 weeks week NNS cord-333672-ef53l283 143 23 ( ( -LRB- cord-333672-ef53l283 143 24 66 66 CD cord-333672-ef53l283 143 25 ) ) -RRB- cord-333672-ef53l283 143 26 . . . cord-333672-ef53l283 144 1 One one CD cord-333672-ef53l283 144 2 group group NN cord-333672-ef53l283 144 3 consumed consume VBD cord-333672-ef53l283 144 4 half half NN cord-333672-ef53l283 144 5 of of IN cord-333672-ef53l283 144 6 their -PRON- PRP$ cord-333672-ef53l283 144 7 daily daily JJ cord-333672-ef53l283 144 8 energy energy NN cord-333672-ef53l283 144 9 intakes intake NNS cord-333672-ef53l283 144 10 at at IN cord-333672-ef53l283 144 11 breakfast breakfast NN cord-333672-ef53l283 144 12 , , , cord-333672-ef53l283 144 13 the the DT cord-333672-ef53l283 144 14 other other JJ cord-333672-ef53l283 144 15 group group NN cord-333672-ef53l283 144 16 consumed consume VBD cord-333672-ef53l283 144 17 half half NN cord-333672-ef53l283 144 18 at at IN cord-333672-ef53l283 144 19 dinner dinner NN cord-333672-ef53l283 144 20 . . . cord-333672-ef53l283 145 1 The the DT cord-333672-ef53l283 145 2 group group NN cord-333672-ef53l283 145 3 that that WDT cord-333672-ef53l283 145 4 consumed consume VBD cord-333672-ef53l283 145 5 half half NN cord-333672-ef53l283 145 6 at at IN cord-333672-ef53l283 145 7 breakfast breakfast NN cord-333672-ef53l283 145 8 lost lose VBD cord-333672-ef53l283 145 9 more more JJR cord-333672-ef53l283 145 10 than than IN cord-333672-ef53l283 145 11 twice twice RB cord-333672-ef53l283 145 12 as as RB cord-333672-ef53l283 145 13 much much JJ cord-333672-ef53l283 145 14 bodyweight bodyweight NN cord-333672-ef53l283 145 15 , , , cord-333672-ef53l283 145 16 more more RBR cord-333672-ef53l283 145 17 than than IN cord-333672-ef53l283 145 18 twice twice PDT cord-333672-ef53l283 145 19 as as RB cord-333672-ef53l283 145 20 many many JJ cord-333672-ef53l283 145 21 centimetres centimetre NNS cord-333672-ef53l283 145 22 off off IN cord-333672-ef53l283 145 23 their -PRON- PRP$ cord-333672-ef53l283 145 24 waists waist NNS cord-333672-ef53l283 145 25 , , , cord-333672-ef53l283 145 26 and and CC cord-333672-ef53l283 145 27 had have VBD cord-333672-ef53l283 145 28 greater great JJR cord-333672-ef53l283 145 29 improvements improvement NNS cord-333672-ef53l283 145 30 in in IN cord-333672-ef53l283 145 31 oral oral JJ cord-333672-ef53l283 145 32 glucose glucose NN cord-333672-ef53l283 145 33 tolerance tolerance NN cord-333672-ef53l283 145 34 . . . cord-333672-ef53l283 146 1 Subsequent subsequent JJ cord-333672-ef53l283 146 2 work work NN cord-333672-ef53l283 146 3 by by IN cord-333672-ef53l283 146 4 the the DT cord-333672-ef53l283 146 5 same same JJ cord-333672-ef53l283 146 6 scientists scientist NNS cord-333672-ef53l283 146 7 demonstrated demonstrate VBD cord-333672-ef53l283 146 8 that that IN cord-333672-ef53l283 146 9 when when WRB cord-333672-ef53l283 146 10 energy energy NN cord-333672-ef53l283 146 11 intake intake NN cord-333672-ef53l283 146 12 is be VBZ cord-333672-ef53l283 146 13 controlled control VBN cord-333672-ef53l283 146 14 , , , cord-333672-ef53l283 146 15 concentrating concentrate VBG cord-333672-ef53l283 146 16 energy energy NN cord-333672-ef53l283 146 17 and and CC cord-333672-ef53l283 146 18 carbohydrate carbohydrate NN cord-333672-ef53l283 146 19 intakes intake NNS cord-333672-ef53l283 146 20 early early RB cord-333672-ef53l283 146 21 in in IN cord-333672-ef53l283 146 22 the the DT cord-333672-ef53l283 146 23 day day NN cord-333672-ef53l283 146 24 leads lead VBZ cord-333672-ef53l283 146 25 to to IN cord-333672-ef53l283 146 26 enhanced enhanced JJ cord-333672-ef53l283 146 27 appetite appetite NN cord-333672-ef53l283 146 28 regulation regulation NN cord-333672-ef53l283 146 29 , , , cord-333672-ef53l283 146 30 weight weight NN cord-333672-ef53l283 146 31 loss loss NN cord-333672-ef53l283 146 32 , , , cord-333672-ef53l283 146 33 and and CC cord-333672-ef53l283 146 34 dramatic dramatic JJ cord-333672-ef53l283 146 35 improvements improvement NNS cord-333672-ef53l283 146 36 in in IN cord-333672-ef53l283 146 37 glycaemic glycaemic JJ cord-333672-ef53l283 146 38 control control NN cord-333672-ef53l283 146 39 in in IN cord-333672-ef53l283 146 40 adults adult NNS cord-333672-ef53l283 146 41 with with IN cord-333672-ef53l283 146 42 type-2 type-2 NN cord-333672-ef53l283 146 43 diabetes diabete NNS cord-333672-ef53l283 146 44 ( ( -LRB- cord-333672-ef53l283 146 45 67 67 CD cord-333672-ef53l283 146 46 ) ) -RRB- cord-333672-ef53l283 146 47 . . . cord-333672-ef53l283 147 1 This this DT cord-333672-ef53l283 147 2 builds build VBZ cord-333672-ef53l283 147 3 on on IN cord-333672-ef53l283 147 4 research research NN cord-333672-ef53l283 147 5 demonstrating demonstrate VBG cord-333672-ef53l283 147 6 that that IN cord-333672-ef53l283 147 7 having have VBG cord-333672-ef53l283 147 8 carbohydrate carbohydrate NN cord-333672-ef53l283 147 9 - - HYPH cord-333672-ef53l283 147 10 rich rich JJ cord-333672-ef53l283 147 11 meals meal NNS cord-333672-ef53l283 147 12 early early RB cord-333672-ef53l283 147 13 in in IN cord-333672-ef53l283 147 14 the the DT cord-333672-ef53l283 147 15 day day NN cord-333672-ef53l283 147 16 reduces reduce VBZ cord-333672-ef53l283 147 17 24-h 24-h JJ cord-333672-ef53l283 147 18 glycaemia glycaemia NN cord-333672-ef53l283 147 19 in in IN cord-333672-ef53l283 147 20 adults adult NNS cord-333672-ef53l283 147 21 with with IN cord-333672-ef53l283 147 22 impaired impair VBN cord-333672-ef53l283 147 23 fasting fast VBG cord-333672-ef53l283 147 24 glucose glucose NN cord-333672-ef53l283 148 1 and/or and/or CC cord-333672-ef53l283 148 2 impaired impaired JJ cord-333672-ef53l283 148 3 glucose glucose NN cord-333672-ef53l283 148 4 tolerance tolerance NN cord-333672-ef53l283 148 5 ( ( -LRB- cord-333672-ef53l283 148 6 68 68 CD cord-333672-ef53l283 148 7 ) ) -RRB- cord-333672-ef53l283 148 8 . . . cord-333672-ef53l283 149 1 While while IN cord-333672-ef53l283 149 2 these these DT cord-333672-ef53l283 149 3 studies study NNS cord-333672-ef53l283 149 4 highlight highlight VBP cord-333672-ef53l283 149 5 the the DT cord-333672-ef53l283 149 6 advantages advantage NNS cord-333672-ef53l283 149 7 of of IN cord-333672-ef53l283 149 8 concentrating concentrate VBG cord-333672-ef53l283 149 9 energy energy NN cord-333672-ef53l283 149 10 and and CC cord-333672-ef53l283 149 11 carbohydrate carbohydrate NN cord-333672-ef53l283 149 12 intakes intake NNS cord-333672-ef53l283 149 13 relatively relatively RB cord-333672-ef53l283 149 14 early early RB cord-333672-ef53l283 149 15 in in IN cord-333672-ef53l283 149 16 the the DT cord-333672-ef53l283 149 17 caloric caloric JJ cord-333672-ef53l283 149 18 period period NN cord-333672-ef53l283 149 19 , , , cord-333672-ef53l283 149 20 we -PRON- PRP cord-333672-ef53l283 149 21 note note VBP cord-333672-ef53l283 149 22 that that IN cord-333672-ef53l283 149 23 that that DT cord-333672-ef53l283 149 24 intelligent intelligent JJ cord-333672-ef53l283 149 25 inclusion inclusion NN cord-333672-ef53l283 149 26 of of IN cord-333672-ef53l283 149 27 physical physical JJ cord-333672-ef53l283 149 28 activity activity NN cord-333672-ef53l283 149 29 leads lead VBZ cord-333672-ef53l283 149 30 to to IN cord-333672-ef53l283 149 31 acute acute JJ cord-333672-ef53l283 149 32 improvements improvement NNS cord-333672-ef53l283 149 33 in in IN cord-333672-ef53l283 149 34 postprandial postprandial JJ cord-333672-ef53l283 149 35 responses response NNS cord-333672-ef53l283 149 36 to to IN cord-333672-ef53l283 149 37 dietary dietary JJ cord-333672-ef53l283 149 38 events event NNS cord-333672-ef53l283 150 1 such such JJ cord-333672-ef53l283 150 2 that that IN cord-333672-ef53l283 150 3 relatively relatively RB cord-333672-ef53l283 150 4 high high JJ cord-333672-ef53l283 150 5 energy energy NN cord-333672-ef53l283 150 6 and and CC cord-333672-ef53l283 150 7 carbohydrate carbohydrate NN cord-333672-ef53l283 150 8 intakes intake NNS cord-333672-ef53l283 150 9 late late RB cord-333672-ef53l283 150 10 in in IN cord-333672-ef53l283 150 11 the the DT cord-333672-ef53l283 150 12 biological biological JJ cord-333672-ef53l283 150 13 day day NN cord-333672-ef53l283 150 14 may may MD cord-333672-ef53l283 150 15 not not RB cord-333672-ef53l283 150 16 be be VB cord-333672-ef53l283 150 17 so so RB cord-333672-ef53l283 150 18 problematic problematic JJ cord-333672-ef53l283 150 19 if if IN cord-333672-ef53l283 150 20 they -PRON- PRP cord-333672-ef53l283 150 21 bookend bookend VBP cord-333672-ef53l283 150 22 exercise exercise NN cord-333672-ef53l283 150 23 ( ( -LRB- cord-333672-ef53l283 150 24 69 69 CD cord-333672-ef53l283 150 25 ) ) -RRB- cord-333672-ef53l283 150 26 . . . cord-333672-ef53l283 151 1 And and CC cord-333672-ef53l283 151 2 staying stay VBG cord-333672-ef53l283 151 3 on on IN cord-333672-ef53l283 151 4 the the DT cord-333672-ef53l283 151 5 subject subject NN cord-333672-ef53l283 151 6 of of IN cord-333672-ef53l283 151 7 exercise exercise NN cord-333672-ef53l283 151 8 , , , cord-333672-ef53l283 151 9 there there EX cord-333672-ef53l283 151 10 is be VBZ cord-333672-ef53l283 151 11 tentative tentative JJ cord-333672-ef53l283 151 12 evidence evidence NN cord-333672-ef53l283 151 13 that that IN cord-333672-ef53l283 151 14 distribution distribution NN cord-333672-ef53l283 151 15 of of IN cord-333672-ef53l283 151 16 daily daily JJ cord-333672-ef53l283 151 17 protein protein NN cord-333672-ef53l283 151 18 intake intake NN cord-333672-ef53l283 151 19 affects affect VBZ cord-333672-ef53l283 151 20 skeletal skeletal JJ cord-333672-ef53l283 151 21 muscle muscle NN cord-333672-ef53l283 151 22 protein protein NN cord-333672-ef53l283 151 23 synthetic synthetic JJ cord-333672-ef53l283 151 24 responses response NNS cord-333672-ef53l283 151 25 to to IN cord-333672-ef53l283 151 26 resistance resistance NN cord-333672-ef53l283 151 27 training training NN cord-333672-ef53l283 151 28 ( ( -LRB- cord-333672-ef53l283 151 29 70 70 CD cord-333672-ef53l283 151 30 ) ) -RRB- cord-333672-ef53l283 151 31 . . . cord-333672-ef53l283 152 1 As as IN cord-333672-ef53l283 152 2 muscle muscle NN cord-333672-ef53l283 152 3 protein protein NN cord-333672-ef53l283 152 4 synthesis synthesis NN cord-333672-ef53l283 152 5 is be VBZ cord-333672-ef53l283 152 6 the the DT cord-333672-ef53l283 152 7 main main JJ cord-333672-ef53l283 152 8 determinant determinant NN cord-333672-ef53l283 152 9 of of IN cord-333672-ef53l283 152 10 muscle muscle NN cord-333672-ef53l283 152 11 protein protein NN cord-333672-ef53l283 152 12 balance balance NN cord-333672-ef53l283 152 13 , , , cord-333672-ef53l283 152 14 it -PRON- PRP cord-333672-ef53l283 152 15 is be VBZ cord-333672-ef53l283 152 16 reasonable reasonable JJ cord-333672-ef53l283 152 17 to to TO cord-333672-ef53l283 152 18 assume assume VB cord-333672-ef53l283 152 19 that that IN cord-333672-ef53l283 152 20 evenly evenly RB cord-333672-ef53l283 152 21 dividing divide VBG cord-333672-ef53l283 152 22 and and CC cord-333672-ef53l283 152 23 spacing space VBG cord-333672-ef53l283 152 24 protein protein NN cord-333672-ef53l283 152 25 intakes intake NNS cord-333672-ef53l283 152 26 between between IN cord-333672-ef53l283 152 27 3 3 CD cord-333672-ef53l283 152 28 and and CC cord-333672-ef53l283 152 29 4 4 CD cord-333672-ef53l283 152 30 daily daily JJ cord-333672-ef53l283 152 31 dietary dietary JJ cord-333672-ef53l283 152 32 events event NNS cord-333672-ef53l283 152 33 may may MD cord-333672-ef53l283 152 34 help help VB cord-333672-ef53l283 152 35 maximise maximise VB cord-333672-ef53l283 152 36 fat fat JJ cord-333672-ef53l283 152 37 - - HYPH cord-333672-ef53l283 152 38 free free JJ cord-333672-ef53l283 152 39 mass mass NN cord-333672-ef53l283 152 40 , , , cord-333672-ef53l283 152 41 a a DT cord-333672-ef53l283 152 42 key key JJ cord-333672-ef53l283 152 43 determinant determinant NN cord-333672-ef53l283 152 44 of of IN cord-333672-ef53l283 152 45 cardiometabolic cardiometabolic JJ cord-333672-ef53l283 152 46 health health NN cord-333672-ef53l283 152 47 ( ( -LRB- cord-333672-ef53l283 152 48 43 43 CD cord-333672-ef53l283 152 49 ) ) -RRB- cord-333672-ef53l283 152 50 . . . cord-333672-ef53l283 153 1 We -PRON- PRP cord-333672-ef53l283 153 2 would would MD cord-333672-ef53l283 153 3 be be VB cord-333672-ef53l283 153 4 negligent negligent JJ cord-333672-ef53l283 153 5 to to TO cord-333672-ef53l283 153 6 not not RB cord-333672-ef53l283 153 7 mention mention VB cord-333672-ef53l283 153 8 that that IN cord-333672-ef53l283 153 9 the the DT cord-333672-ef53l283 153 10 sequence sequence NN cord-333672-ef53l283 153 11 of of IN cord-333672-ef53l283 153 12 macronutrient macronutrient NN cord-333672-ef53l283 153 13 intakes intake NNS cord-333672-ef53l283 153 14 within within IN cord-333672-ef53l283 153 15 dietary dietary JJ cord-333672-ef53l283 153 16 events event NNS cord-333672-ef53l283 153 17 may may MD cord-333672-ef53l283 153 18 also also RB cord-333672-ef53l283 153 19 meaningfully meaningfully RB cord-333672-ef53l283 153 20 affect affect VB cord-333672-ef53l283 153 21 postprandial postprandial JJ cord-333672-ef53l283 153 22 responses response NNS cord-333672-ef53l283 153 23 . . . cord-333672-ef53l283 154 1 Several several JJ cord-333672-ef53l283 154 2 studies study NNS cord-333672-ef53l283 154 3 by by IN cord-333672-ef53l283 154 4 one one CD cord-333672-ef53l283 154 5 research research NN cord-333672-ef53l283 154 6 group group NN cord-333672-ef53l283 154 7 have have VBP cord-333672-ef53l283 154 8 shown show VBN cord-333672-ef53l283 154 9 that that IN cord-333672-ef53l283 154 10 consuming consume VBG cord-333672-ef53l283 154 11 carbohydrate carbohydrate NN cord-333672-ef53l283 154 12 last last RB cord-333672-ef53l283 154 13 at at IN cord-333672-ef53l283 154 14 a a DT cord-333672-ef53l283 154 15 given give VBN cord-333672-ef53l283 154 16 dietary dietary JJ cord-333672-ef53l283 154 17 event event NN cord-333672-ef53l283 154 18 ( ( -LRB- cord-333672-ef53l283 154 19 e.g. e.g. RB cord-333672-ef53l283 154 20 , , , cord-333672-ef53l283 154 21 a a DT cord-333672-ef53l283 154 22 full full JJ cord-333672-ef53l283 154 23 meal meal NN cord-333672-ef53l283 154 24 ) ) -RRB- cord-333672-ef53l283 154 25 dramatically dramatically RB cord-333672-ef53l283 154 26 reduces reduce VBZ cord-333672-ef53l283 154 27 postprandial postprandial JJ cord-333672-ef53l283 154 28 glycaemia glycaemia NN cord-333672-ef53l283 154 29 and and CC cord-333672-ef53l283 154 30 insulinaemia insulinaemia NN cord-333672-ef53l283 154 31 in in IN cord-333672-ef53l283 154 32 adults adult NNS cord-333672-ef53l283 154 33 who who WP cord-333672-ef53l283 154 34 have have VBP cord-333672-ef53l283 154 35 prediabetes prediabete NNS cord-333672-ef53l283 154 36 or or CC cord-333672-ef53l283 154 37 type type NN cord-333672-ef53l283 154 38 - - HYPH cord-333672-ef53l283 154 39 two two CD cord-333672-ef53l283 154 40 diabetes diabete NNS cord-333672-ef53l283 154 41 ( ( -LRB- cord-333672-ef53l283 154 42 71 71 CD cord-333672-ef53l283 154 43 ) ) -RRB- cord-333672-ef53l283 154 44 ( ( -LRB- cord-333672-ef53l283 154 45 72 72 CD cord-333672-ef53l283 154 46 ) ) -RRB- cord-333672-ef53l283 154 47 ( ( -LRB- cord-333672-ef53l283 154 48 73 73 CD cord-333672-ef53l283 154 49 ) ) -RRB- cord-333672-ef53l283 154 50 . . . cord-333672-ef53l283 155 1 Shift shift JJ cord-333672-ef53l283 155 2 workers worker NNS cord-333672-ef53l283 155 3 who who WP cord-333672-ef53l283 155 4 have have VBP cord-333672-ef53l283 155 5 poor poor JJ cord-333672-ef53l283 155 6 glycaemic glycaemic JJ cord-333672-ef53l283 155 7 control control NN cord-333672-ef53l283 155 8 may may MD cord-333672-ef53l283 155 9 hence hence RB cord-333672-ef53l283 155 10 benefit benefit VB cord-333672-ef53l283 155 11 from from IN cord-333672-ef53l283 155 12 consuming consume VBG cord-333672-ef53l283 155 13 carbohydrate carbohydrate NN cord-333672-ef53l283 155 14 - - HYPH cord-333672-ef53l283 155 15 rich rich JJ cord-333672-ef53l283 155 16 foods food NNS cord-333672-ef53l283 155 17 last last JJ cord-333672-ef53l283 155 18 at at IN cord-333672-ef53l283 155 19 dietary dietary JJ cord-333672-ef53l283 155 20 events event NNS cord-333672-ef53l283 155 21 , , , cord-333672-ef53l283 155 22 when when WRB cord-333672-ef53l283 155 23 practical practical JJ cord-333672-ef53l283 155 24 . . . cord-333672-ef53l283 156 1 Most Most JJS cord-333672-ef53l283 156 2 shift shift NN cord-333672-ef53l283 156 3 workers worker NNS cord-333672-ef53l283 156 4 snack snack NN cord-333672-ef53l283 156 5 during during IN cord-333672-ef53l283 156 6 night night NN cord-333672-ef53l283 156 7 shifts shift NNS cord-333672-ef53l283 156 8 . . . cord-333672-ef53l283 157 1 The the DT cord-333672-ef53l283 157 2 problem problem NN cord-333672-ef53l283 157 3 is be VBZ cord-333672-ef53l283 157 4 that that DT cord-333672-ef53l283 157 5 night night NN cord-333672-ef53l283 157 6 shifts shift NNS cord-333672-ef53l283 157 7 often often RB cord-333672-ef53l283 157 8 occur occur VBP cord-333672-ef53l283 157 9 during during IN cord-333672-ef53l283 157 10 the the DT cord-333672-ef53l283 157 11 workers worker NNS cord-333672-ef53l283 157 12 ' ' POS cord-333672-ef53l283 157 13 biological biological JJ cord-333672-ef53l283 157 14 nighttimes nighttimes NN cord-333672-ef53l283 157 15 , , , cord-333672-ef53l283 157 16 and and CC cord-333672-ef53l283 157 17 digestive digestive JJ cord-333672-ef53l283 157 18 and and CC cord-333672-ef53l283 157 19 metabolic metabolic JJ cord-333672-ef53l283 157 20 responses response NNS cord-333672-ef53l283 157 21 to to IN cord-333672-ef53l283 157 22 dietary dietary JJ cord-333672-ef53l283 157 23 events event NNS cord-333672-ef53l283 157 24 are be VBP cord-333672-ef53l283 157 25 impaired impair VBN cord-333672-ef53l283 157 26 during during IN cord-333672-ef53l283 157 27 the the DT cord-333672-ef53l283 157 28 biological biological JJ cord-333672-ef53l283 157 29 night night NN cord-333672-ef53l283 157 30 ( ( -LRB- cord-333672-ef53l283 157 31 74 74 CD cord-333672-ef53l283 157 32 ) ) -RRB- cord-333672-ef53l283 157 33 . . . cord-333672-ef53l283 158 1 As as IN cord-333672-ef53l283 158 2 highlighted highlight VBN cord-333672-ef53l283 158 3 earlier early RBR cord-333672-ef53l283 158 4 , , , cord-333672-ef53l283 158 5 eating eat VBG cord-333672-ef53l283 158 6 and/or and/or CC cord-333672-ef53l283 158 7 drinking drink VBG cord-333672-ef53l283 158 8 during during IN cord-333672-ef53l283 158 9 the the DT cord-333672-ef53l283 158 10 biological biological JJ cord-333672-ef53l283 158 11 night night NN cord-333672-ef53l283 158 12 - - HYPH cord-333672-ef53l283 158 13 time time NN cord-333672-ef53l283 158 14 may may MD cord-333672-ef53l283 158 15 disrupt disrupt VB cord-333672-ef53l283 158 16 peripheral peripheral JJ cord-333672-ef53l283 158 17 clocks clock NNS cord-333672-ef53l283 158 18 . . . cord-333672-ef53l283 159 1 If if IN cord-333672-ef53l283 159 2 workers worker NNS cord-333672-ef53l283 159 3 snack snack NN cord-333672-ef53l283 159 4 during during IN cord-333672-ef53l283 159 5 night night NN cord-333672-ef53l283 159 6 shifts shift NNS cord-333672-ef53l283 159 7 , , , cord-333672-ef53l283 159 8 it -PRON- PRP cord-333672-ef53l283 159 9 is be VBZ cord-333672-ef53l283 159 10 therefore therefore RB cord-333672-ef53l283 159 11 important important JJ cord-333672-ef53l283 159 12 to to TO cord-333672-ef53l283 159 13 minimise minimise VB cord-333672-ef53l283 159 14 energy energy NN cord-333672-ef53l283 159 15 intake intake NN cord-333672-ef53l283 159 16 and and CC cord-333672-ef53l283 159 17 select select JJ cord-333672-ef53l283 159 18 dietary dietary JJ cord-333672-ef53l283 159 19 choices choice NNS cord-333672-ef53l283 159 20 that that WDT cord-333672-ef53l283 159 21 lead lead VBP cord-333672-ef53l283 159 22 to to IN cord-333672-ef53l283 159 23 favourable favourable JJ cord-333672-ef53l283 159 24 postprandial postprandial JJ cord-333672-ef53l283 159 25 responses response NNS cord-333672-ef53l283 159 26 . . . cord-333672-ef53l283 160 1 These these DT cord-333672-ef53l283 160 2 snacks snack NNS cord-333672-ef53l283 160 3 should should MD cord-333672-ef53l283 160 4 also also RB cord-333672-ef53l283 160 5 be be VB cord-333672-ef53l283 160 6 convenient convenient JJ cord-333672-ef53l283 160 7 , , , cord-333672-ef53l283 160 8 minimally minimally RB cord-333672-ef53l283 160 9 processed process VBN cord-333672-ef53l283 160 10 , , , cord-333672-ef53l283 160 11 micronutrient micronutrient NN cord-333672-ef53l283 160 12 - - HYPH cord-333672-ef53l283 160 13 dense dense JJ cord-333672-ef53l283 160 14 , , , cord-333672-ef53l283 160 15 satiating satiating JJ cord-333672-ef53l283 160 16 , , , cord-333672-ef53l283 160 17 easy easy JJ cord-333672-ef53l283 160 18 to to TO cord-333672-ef53l283 160 19 digest digest VB cord-333672-ef53l283 160 20 , , , cord-333672-ef53l283 160 21 and and CC cord-333672-ef53l283 160 22 minimally minimally RB cord-333672-ef53l283 160 23 perishable perishable JJ cord-333672-ef53l283 160 24 , , , cord-333672-ef53l283 160 25 when when WRB cord-333672-ef53l283 160 26 applicable applicable JJ cord-333672-ef53l283 160 27 . . . cord-333672-ef53l283 161 1 Preliminary preliminary JJ cord-333672-ef53l283 161 2 research research NN cord-333672-ef53l283 161 3 has have VBZ cord-333672-ef53l283 161 4 shown show VBN cord-333672-ef53l283 161 5 that that IN cord-333672-ef53l283 161 6 when when WRB cord-333672-ef53l283 161 7 24-h 24-h JJ cord-333672-ef53l283 161 8 energy energy NN cord-333672-ef53l283 161 9 and and CC cord-333672-ef53l283 161 10 macronutrient macronutrient NN cord-333672-ef53l283 161 11 intakes intake NNS cord-333672-ef53l283 161 12 are be VBP cord-333672-ef53l283 161 13 controlled control VBN cord-333672-ef53l283 161 14 during during IN cord-333672-ef53l283 161 15 simulated simulated JJ cord-333672-ef53l283 161 16 night night NN cord-333672-ef53l283 161 17 shifts shift NNS cord-333672-ef53l283 161 18 , , , cord-333672-ef53l283 161 19 a a DT cord-333672-ef53l283 161 20 small small JJ cord-333672-ef53l283 161 21 snack snack NN cord-333672-ef53l283 161 22 ( ( -LRB- cord-333672-ef53l283 161 23 containing contain VBG cord-333672-ef53l283 161 24 10 10 CD cord-333672-ef53l283 161 25 % % NN cord-333672-ef53l283 161 26 of of IN cord-333672-ef53l283 161 27 daily daily JJ cord-333672-ef53l283 161 28 energy energy NN cord-333672-ef53l283 161 29 intake intake NN cord-333672-ef53l283 161 30 ) ) -RRB- cord-333672-ef53l283 161 31 may may MD cord-333672-ef53l283 161 32 support support VB cord-333672-ef53l283 161 33 cognitive cognitive JJ cord-333672-ef53l283 161 34 function function NN cord-333672-ef53l283 161 35 and and CC cord-333672-ef53l283 161 36 performance performance NN cord-333672-ef53l283 161 37 in in IN cord-333672-ef53l283 161 38 simulated simulated JJ cord-333672-ef53l283 161 39 driving driving NN cord-333672-ef53l283 161 40 compared compare VBN cord-333672-ef53l283 161 41 with with IN cord-333672-ef53l283 161 42 no no DT cord-333672-ef53l283 161 43 snacking snacking NN cord-333672-ef53l283 161 44 or or CC cord-333672-ef53l283 161 45 a a DT cord-333672-ef53l283 161 46 larger large JJR cord-333672-ef53l283 161 47 meal meal NN cord-333672-ef53l283 161 48 containing contain VBG cord-333672-ef53l283 161 49 30 30 CD cord-333672-ef53l283 161 50 % % NN cord-333672-ef53l283 161 51 of of IN cord-333672-ef53l283 161 52 daily daily JJ cord-333672-ef53l283 161 53 energy energy NN cord-333672-ef53l283 161 54 intake intake NN cord-333672-ef53l283 161 55 ( ( -LRB- cord-333672-ef53l283 161 56 75 75 CD cord-333672-ef53l283 161 57 ) ) -RRB- cord-333672-ef53l283 161 58 . . . cord-333672-ef53l283 162 1 In in IN cord-333672-ef53l283 162 2 this this DT cord-333672-ef53l283 162 3 instance instance NN cord-333672-ef53l283 162 4 , , , cord-333672-ef53l283 162 5 the the DT cord-333672-ef53l283 162 6 small small JJ cord-333672-ef53l283 162 7 snack snack NN cord-333672-ef53l283 162 8 also also RB cord-333672-ef53l283 162 9 reduced reduce VBD cord-333672-ef53l283 162 10 hunger hunger NN cord-333672-ef53l283 162 11 to to IN cord-333672-ef53l283 162 12 a a DT cord-333672-ef53l283 162 13 comparable comparable JJ cord-333672-ef53l283 162 14 extent extent NN cord-333672-ef53l283 162 15 to to IN cord-333672-ef53l283 162 16 the the DT cord-333672-ef53l283 162 17 meal meal NN cord-333672-ef53l283 162 18 , , , cord-333672-ef53l283 162 19 without without IN cord-333672-ef53l283 162 20 leading lead VBG cord-333672-ef53l283 162 21 to to IN cord-333672-ef53l283 162 22 significant significant JJ cord-333672-ef53l283 162 23 digestive digestive JJ cord-333672-ef53l283 162 24 discomfort discomfort NN cord-333672-ef53l283 162 25 ( ( -LRB- cord-333672-ef53l283 162 26 76 76 CD cord-333672-ef53l283 162 27 ) ) -RRB- cord-333672-ef53l283 162 28 . . . cord-333672-ef53l283 163 1 Compared compare VBN cord-333672-ef53l283 163 2 to to IN cord-333672-ef53l283 163 3 large large JJ cord-333672-ef53l283 163 4 night night NN cord-333672-ef53l283 163 5 - - HYPH cord-333672-ef53l283 163 6 time time NN cord-333672-ef53l283 163 7 snacks snack NNS cord-333672-ef53l283 163 8 , , , cord-333672-ef53l283 163 9 small small JJ cord-333672-ef53l283 163 10 night night NN cord-333672-ef53l283 163 11 - - HYPH cord-333672-ef53l283 163 12 time time NN cord-333672-ef53l283 163 13 snacks snack NNS cord-333672-ef53l283 163 14 may may MD cord-333672-ef53l283 163 15 also also RB cord-333672-ef53l283 163 16 be be VB cord-333672-ef53l283 163 17 better well JJR cord-333672-ef53l283 163 18 for for IN cord-333672-ef53l283 163 19 metabolic metabolic JJ cord-333672-ef53l283 163 20 health health NN cord-333672-ef53l283 163 21 . . . cord-333672-ef53l283 164 1 Glycaemic Glycaemic NNP cord-333672-ef53l283 164 2 control control NN cord-333672-ef53l283 164 3 is be VBZ cord-333672-ef53l283 164 4 relatively relatively RB cord-333672-ef53l283 164 5 easy easy JJ cord-333672-ef53l283 164 6 to to TO cord-333672-ef53l283 164 7 measure measure VB cord-333672-ef53l283 164 8 and and CC cord-333672-ef53l283 164 9 predictive predictive NN cord-333672-ef53l283 164 10 of of IN cord-333672-ef53l283 164 11 many many JJ cord-333672-ef53l283 164 12 health health NN cord-333672-ef53l283 164 13 outcomes outcome NNS cord-333672-ef53l283 164 14 , , , cord-333672-ef53l283 164 15 and and CC cord-333672-ef53l283 164 16 some some DT cord-333672-ef53l283 164 17 researchers researcher NNS cord-333672-ef53l283 164 18 have have VBP cord-333672-ef53l283 164 19 therefore therefore RB cord-333672-ef53l283 164 20 focused focus VBN cord-333672-ef53l283 164 21 on on IN cord-333672-ef53l283 164 22 the the DT cord-333672-ef53l283 164 23 effects effect NNS cord-333672-ef53l283 164 24 of of IN cord-333672-ef53l283 164 25 nocturnal nocturnal JJ cord-333672-ef53l283 164 26 snacking snacking NN cord-333672-ef53l283 164 27 on on IN cord-333672-ef53l283 164 28 glycaemic glycaemic JJ cord-333672-ef53l283 164 29 control control NN cord-333672-ef53l283 164 30 . . . cord-333672-ef53l283 165 1 Compared compare VBN cord-333672-ef53l283 165 2 with with IN cord-333672-ef53l283 165 3 a a DT cord-333672-ef53l283 165 4 small small JJ cord-333672-ef53l283 165 5 midnight midnight NN cord-333672-ef53l283 165 6 snack snack NN cord-333672-ef53l283 165 7 ( ( -LRB- cord-333672-ef53l283 165 8 ∼200 ∼200 NNP cord-333672-ef53l283 165 9 calories calories NNP cord-333672-ef53l283 165 10 ) ) -RRB- cord-333672-ef53l283 165 11 , , , cord-333672-ef53l283 165 12 a a DT cord-333672-ef53l283 165 13 large large JJ cord-333672-ef53l283 165 14 midnight midnight NN cord-333672-ef53l283 165 15 snack snack NN cord-333672-ef53l283 165 16 ( ( -LRB- cord-333672-ef53l283 165 17 ∼500 ∼500 NNP cord-333672-ef53l283 165 18 calories calorie NNS cord-333672-ef53l283 165 19 ) ) -RRB- cord-333672-ef53l283 165 20 impaired impair VBD cord-333672-ef53l283 165 21 postprandial postprandial JJ cord-333672-ef53l283 165 22 glycaemic glycaemic JJ cord-333672-ef53l283 165 23 responses response NNS cord-333672-ef53l283 165 24 at at IN cord-333672-ef53l283 165 25 a a DT cord-333672-ef53l283 165 26 subsequent subsequent JJ cord-333672-ef53l283 165 27 breakfast breakfast NN cord-333672-ef53l283 165 28 at at IN cord-333672-ef53l283 165 29 08:30 08:30 CD cord-333672-ef53l283 165 30 during during IN cord-333672-ef53l283 165 31 simulated simulated JJ cord-333672-ef53l283 165 32 shift shift NN cord-333672-ef53l283 165 33 work work NN cord-333672-ef53l283 165 34 ( ( -LRB- cord-333672-ef53l283 165 35 77 77 CD cord-333672-ef53l283 165 36 ) ) -RRB- cord-333672-ef53l283 165 37 . . . cord-333672-ef53l283 166 1 Research research NN cord-333672-ef53l283 166 2 such such JJ cord-333672-ef53l283 166 3 as as IN cord-333672-ef53l283 166 4 this this DT cord-333672-ef53l283 166 5 is be VBZ cord-333672-ef53l283 166 6 informative informative JJ cord-333672-ef53l283 166 7 , , , cord-333672-ef53l283 166 8 but but CC cord-333672-ef53l283 166 9 we -PRON- PRP cord-333672-ef53l283 166 10 again again RB cord-333672-ef53l283 166 11 need need VBP cord-333672-ef53l283 166 12 additional additional JJ cord-333672-ef53l283 166 13 studies study NNS cord-333672-ef53l283 166 14 of of IN cord-333672-ef53l283 166 15 workers worker NNS cord-333672-ef53l283 166 16 in in IN cord-333672-ef53l283 166 17 which which WDT cord-333672-ef53l283 166 18 the the DT cord-333672-ef53l283 166 19 effects effect NNS cord-333672-ef53l283 166 20 of of IN cord-333672-ef53l283 166 21 dietary dietary JJ cord-333672-ef53l283 166 22 changes change NNS cord-333672-ef53l283 166 23 on on IN cord-333672-ef53l283 166 24 metabolic metabolic JJ cord-333672-ef53l283 166 25 parameters parameter NNS cord-333672-ef53l283 166 26 are be VBP cord-333672-ef53l283 166 27 measured measure VBN cord-333672-ef53l283 166 28 around around IN cord-333672-ef53l283 166 29 the the DT cord-333672-ef53l283 166 30 clock clock NN cord-333672-ef53l283 166 31 . . . cord-333672-ef53l283 167 1 Shift shift JJ cord-333672-ef53l283 167 2 workers worker NNS cord-333672-ef53l283 167 3 are be VBP cord-333672-ef53l283 167 4 not not RB cord-333672-ef53l283 167 5 only only RB cord-333672-ef53l283 167 6 apt apt JJ cord-333672-ef53l283 167 7 to to TO cord-333672-ef53l283 167 8 consume consume VB cord-333672-ef53l283 167 9 foods food NNS cord-333672-ef53l283 167 10 and and CC cord-333672-ef53l283 167 11 drinks drink NNS cord-333672-ef53l283 167 12 at at IN cord-333672-ef53l283 167 13 suboptimal suboptimal JJ cord-333672-ef53l283 167 14 circadian circadian NN cord-333672-ef53l283 167 15 phases phase NNS cord-333672-ef53l283 167 16 , , , cord-333672-ef53l283 167 17 the the DT cord-333672-ef53l283 167 18 quality quality NN cord-333672-ef53l283 167 19 of of IN cord-333672-ef53l283 167 20 shift shift NN cord-333672-ef53l283 167 21 workers worker NNS cord-333672-ef53l283 167 22 ' ' POS cord-333672-ef53l283 167 23 diets diet NNS cord-333672-ef53l283 167 24 is be VBZ cord-333672-ef53l283 167 25 often often RB cord-333672-ef53l283 167 26 worse bad JJR cord-333672-ef53l283 167 27 than than IN cord-333672-ef53l283 167 28 that that DT cord-333672-ef53l283 167 29 of of IN cord-333672-ef53l283 167 30 day day NN cord-333672-ef53l283 167 31 workers worker NNS cord-333672-ef53l283 167 32 too too RB cord-333672-ef53l283 167 33 . . . cord-333672-ef53l283 168 1 Many many JJ cord-333672-ef53l283 168 2 shift shift NN cord-333672-ef53l283 168 3 workers worker NNS cord-333672-ef53l283 168 4 report report VBP cord-333672-ef53l283 168 5 consuming consume VBG cord-333672-ef53l283 168 6 few few JJ cord-333672-ef53l283 168 7 fruits fruit NNS cord-333672-ef53l283 168 8 and and CC cord-333672-ef53l283 168 9 vegetables vegetable NNS cord-333672-ef53l283 168 10 while while IN cord-333672-ef53l283 168 11 also also RB cord-333672-ef53l283 168 12 consuming consume VBG cord-333672-ef53l283 168 13 a a DT cord-333672-ef53l283 168 14 variety variety NN cord-333672-ef53l283 168 15 of of IN cord-333672-ef53l283 168 16 processed process VBN cord-333672-ef53l283 168 17 foods food NNS cord-333672-ef53l283 168 18 at at IN cord-333672-ef53l283 168 19 work work NN cord-333672-ef53l283 168 20 , , , cord-333672-ef53l283 168 21 such such JJ cord-333672-ef53l283 168 22 as as IN cord-333672-ef53l283 168 23 biscuits biscuit NNS cord-333672-ef53l283 168 24 , , , cord-333672-ef53l283 168 25 cakes cake NNS cord-333672-ef53l283 168 26 , , , cord-333672-ef53l283 168 27 chocolates chocolate NNS cord-333672-ef53l283 168 28 , , , cord-333672-ef53l283 168 29 pastries pastry NNS cord-333672-ef53l283 168 30 , , , cord-333672-ef53l283 168 31 sandwiches sandwich NNS cord-333672-ef53l283 168 32 , , , cord-333672-ef53l283 168 33 and and CC cord-333672-ef53l283 168 34 fried fry VBN cord-333672-ef53l283 168 35 foods food NNS cord-333672-ef53l283 168 36 ( ( -LRB- cord-333672-ef53l283 168 37 42 42 CD cord-333672-ef53l283 168 38 ) ) -RRB- cord-333672-ef53l283 168 39 . . . cord-333672-ef53l283 169 1 As as IN cord-333672-ef53l283 169 2 diet diet NN cord-333672-ef53l283 169 3 composition composition NN cord-333672-ef53l283 169 4 affects affect VBZ cord-333672-ef53l283 169 5 metabolic metabolic JJ cord-333672-ef53l283 169 6 health health NN cord-333672-ef53l283 169 7 and and CC cord-333672-ef53l283 169 8 cognitive cognitive JJ cord-333672-ef53l283 169 9 function function NN cord-333672-ef53l283 169 10 , , , cord-333672-ef53l283 169 11 it -PRON- PRP cord-333672-ef53l283 169 12 is be VBZ cord-333672-ef53l283 169 13 important important JJ cord-333672-ef53l283 169 14 to to TO cord-333672-ef53l283 169 15 help help VB cord-333672-ef53l283 169 16 these these DT cord-333672-ef53l283 169 17 people people NNS cord-333672-ef53l283 169 18 make make VB cord-333672-ef53l283 169 19 better well JJR cord-333672-ef53l283 169 20 dietary dietary JJ cord-333672-ef53l283 169 21 choices choice NNS cord-333672-ef53l283 169 22 . . . cord-333672-ef53l283 170 1 One one CD cord-333672-ef53l283 170 2 way way NN cord-333672-ef53l283 170 3 by by IN cord-333672-ef53l283 170 4 which which WDT cord-333672-ef53l283 170 5 diet diet NN cord-333672-ef53l283 170 6 composition composition NN cord-333672-ef53l283 170 7 influences influence VBZ cord-333672-ef53l283 170 8 health health NN cord-333672-ef53l283 170 9 is be VBZ cord-333672-ef53l283 170 10 via via IN cord-333672-ef53l283 170 11 effects effect NNS cord-333672-ef53l283 170 12 on on IN cord-333672-ef53l283 170 13 the the DT cord-333672-ef53l283 170 14 circadian circadian NN cord-333672-ef53l283 170 15 clockwork clockwork NN cord-333672-ef53l283 170 16 , , , cord-333672-ef53l283 170 17 and and CC cord-333672-ef53l283 170 18 the the DT cord-333672-ef53l283 170 19 ketogenic ketogenic JJ cord-333672-ef53l283 170 20 diet diet NN cord-333672-ef53l283 170 21 ( ( -LRB- cord-333672-ef53l283 170 22 KD KD NNP cord-333672-ef53l283 170 23 ) ) -RRB- cord-333672-ef53l283 170 24 exemplifies exemplify VBZ cord-333672-ef53l283 170 25 this this DT cord-333672-ef53l283 170 26 . . . cord-333672-ef53l283 171 1 There there EX cord-333672-ef53l283 171 2 has have VBZ cord-333672-ef53l283 171 3 been be VBN cord-333672-ef53l283 171 4 a a DT cord-333672-ef53l283 171 5 resurgence resurgence NN cord-333672-ef53l283 171 6 in in IN cord-333672-ef53l283 171 7 interest interest NN cord-333672-ef53l283 171 8 in in IN cord-333672-ef53l283 171 9 the the DT cord-333672-ef53l283 171 10 KD KD NNP cord-333672-ef53l283 171 11 of of IN cord-333672-ef53l283 171 12 late late JJ cord-333672-ef53l283 171 13 , , , cord-333672-ef53l283 171 14 and and CC cord-333672-ef53l283 171 15 while while IN cord-333672-ef53l283 171 16 some some DT cord-333672-ef53l283 171 17 believe believe VBP cord-333672-ef53l283 171 18 that that IN cord-333672-ef53l283 171 19 the the DT cord-333672-ef53l283 171 20 restrictive restrictive JJ cord-333672-ef53l283 171 21 nature nature NN cord-333672-ef53l283 171 22 of of IN cord-333672-ef53l283 171 23 the the DT cord-333672-ef53l283 171 24 KD KD NNP cord-333672-ef53l283 171 25 is be VBZ cord-333672-ef53l283 171 26 a a DT cord-333672-ef53l283 171 27 barrier barrier NN cord-333672-ef53l283 171 28 to to IN cord-333672-ef53l283 171 29 its -PRON- PRP$ cord-333672-ef53l283 171 30 widespread widespread JJ cord-333672-ef53l283 171 31 implementation implementation NN cord-333672-ef53l283 171 32 , , , cord-333672-ef53l283 171 33 certain certain JJ cord-333672-ef53l283 171 34 properties property NNS cord-333672-ef53l283 171 35 of of IN cord-333672-ef53l283 171 36 the the DT cord-333672-ef53l283 171 37 KD KD NNP cord-333672-ef53l283 171 38 make make VB cord-333672-ef53l283 171 39 it -PRON- PRP cord-333672-ef53l283 171 40 an an DT cord-333672-ef53l283 171 41 appealing appealing JJ cord-333672-ef53l283 171 42 option option NN cord-333672-ef53l283 171 43 for for IN cord-333672-ef53l283 171 44 some some DT cord-333672-ef53l283 171 45 shift shift JJ cord-333672-ef53l283 171 46 workers worker NNS cord-333672-ef53l283 171 47 who who WP cord-333672-ef53l283 171 48 are be VBP cord-333672-ef53l283 171 49 able able JJ cord-333672-ef53l283 171 50 to to TO cord-333672-ef53l283 171 51 adhere adhere VB cord-333672-ef53l283 171 52 to to IN cord-333672-ef53l283 171 53 it -PRON- PRP cord-333672-ef53l283 171 54 . . . cord-333672-ef53l283 172 1 Studies study NNS cord-333672-ef53l283 172 2 of of IN cord-333672-ef53l283 172 3 mice mouse NNS cord-333672-ef53l283 172 4 have have VBP cord-333672-ef53l283 172 5 shown show VBN cord-333672-ef53l283 172 6 that that IN cord-333672-ef53l283 172 7 the the DT cord-333672-ef53l283 172 8 KD KD NNP cord-333672-ef53l283 172 9 has have VBZ cord-333672-ef53l283 172 10 chronobiotic chronobiotic JJ cord-333672-ef53l283 172 11 actions action NNS cord-333672-ef53l283 172 12 on on IN cord-333672-ef53l283 172 13 the the DT cord-333672-ef53l283 172 14 clocks clock NNS cord-333672-ef53l283 172 15 in in IN cord-333672-ef53l283 172 16 multiple multiple JJ cord-333672-ef53l283 172 17 peripheral peripheral JJ cord-333672-ef53l283 172 18 tissues tissue NNS cord-333672-ef53l283 172 19 , , , cord-333672-ef53l283 172 20 including include VBG cord-333672-ef53l283 172 21 the the DT cord-333672-ef53l283 172 22 brain brain NN cord-333672-ef53l283 172 23 , , , cord-333672-ef53l283 172 24 gut gut NN cord-333672-ef53l283 172 25 , , , cord-333672-ef53l283 172 26 and and CC cord-333672-ef53l283 172 27 liver liver NN cord-333672-ef53l283 172 28 ( ( -LRB- cord-333672-ef53l283 172 29 78 78 CD cord-333672-ef53l283 172 30 ) ) -RRB- cord-333672-ef53l283 172 31 ( ( -LRB- cord-333672-ef53l283 172 32 79 79 CD cord-333672-ef53l283 172 33 ) ) -RRB- cord-333672-ef53l283 172 34 ( ( -LRB- cord-333672-ef53l283 172 35 80 80 CD cord-333672-ef53l283 172 36 ) ) -RRB- cord-333672-ef53l283 172 37 . . . cord-333672-ef53l283 173 1 Interestingly interestingly RB cord-333672-ef53l283 173 2 , , , cord-333672-ef53l283 173 3 Tognini Tognini NNP cord-333672-ef53l283 173 4 and and CC cord-333672-ef53l283 173 5 colleagues colleague NNS cord-333672-ef53l283 173 6 found find VBD cord-333672-ef53l283 173 7 that that IN cord-333672-ef53l283 173 8 a a DT cord-333672-ef53l283 173 9 KD KD NNP cord-333672-ef53l283 173 10 induced induce VBD cord-333672-ef53l283 173 11 distinct distinct JJ cord-333672-ef53l283 173 12 changes change NNS cord-333672-ef53l283 173 13 in in IN cord-333672-ef53l283 173 14 the the DT cord-333672-ef53l283 173 15 liver liver NN cord-333672-ef53l283 173 16 and and CC cord-333672-ef53l283 173 17 gut gut NN cord-333672-ef53l283 173 18 clocks clock NNS cord-333672-ef53l283 173 19 in in IN cord-333672-ef53l283 173 20 mice mouse NNS cord-333672-ef53l283 173 21 . . . cord-333672-ef53l283 174 1 Compared compare VBN cord-333672-ef53l283 174 2 to to IN cord-333672-ef53l283 174 3 a a DT cord-333672-ef53l283 174 4 control control NN cord-333672-ef53l283 174 5 diet diet NN cord-333672-ef53l283 174 6 , , , cord-333672-ef53l283 174 7 consumption consumption NN cord-333672-ef53l283 174 8 of of IN cord-333672-ef53l283 174 9 a a DT cord-333672-ef53l283 174 10 KD KD NNP cord-333672-ef53l283 174 11 produced produce VBD cord-333672-ef53l283 174 12 greater great JJR cord-333672-ef53l283 174 13 amplitudes amplitude NNS cord-333672-ef53l283 174 14 of of IN cord-333672-ef53l283 174 15 clock clock NN cord-333672-ef53l283 174 16 gene gene NN cord-333672-ef53l283 174 17 transcription transcription NN cord-333672-ef53l283 174 18 and and CC cord-333672-ef53l283 174 19 their -PRON- PRP$ cord-333672-ef53l283 174 20 downstream downstream JJ cord-333672-ef53l283 174 21 products product NNS cord-333672-ef53l283 174 22 in in IN cord-333672-ef53l283 174 23 the the DT cord-333672-ef53l283 174 24 liver liver NN cord-333672-ef53l283 174 25 , , , cord-333672-ef53l283 174 26 as as RB cord-333672-ef53l283 174 27 well well RB cord-333672-ef53l283 174 28 as as IN cord-333672-ef53l283 174 29 inducing induce VBG cord-333672-ef53l283 174 30 24-h 24-h JJ cord-333672-ef53l283 174 31 oscillations oscillation NNS cord-333672-ef53l283 174 32 in in IN cord-333672-ef53l283 174 33 the the DT cord-333672-ef53l283 174 34 transcription transcription NN cord-333672-ef53l283 174 35 of of IN cord-333672-ef53l283 174 36 many many JJ cord-333672-ef53l283 174 37 genes gene NNS cord-333672-ef53l283 174 38 in in IN cord-333672-ef53l283 174 39 the the DT cord-333672-ef53l283 174 40 gut gut NN cord-333672-ef53l283 174 41 ( ( -LRB- cord-333672-ef53l283 174 42 78 78 CD cord-333672-ef53l283 174 43 ) ) -RRB- cord-333672-ef53l283 174 44 . . . cord-333672-ef53l283 175 1 As as IN cord-333672-ef53l283 175 2 disruption disruption NN cord-333672-ef53l283 175 3 of of IN cord-333672-ef53l283 175 4 the the DT cord-333672-ef53l283 175 5 gut gut NN cord-333672-ef53l283 175 6 clock clock NN cord-333672-ef53l283 175 7 is be VBZ cord-333672-ef53l283 175 8 associated associate VBN cord-333672-ef53l283 175 9 with with IN cord-333672-ef53l283 175 10 increased increase VBN cord-333672-ef53l283 175 11 intestinal intestinal JJ cord-333672-ef53l283 175 12 inflammation inflammation NN cord-333672-ef53l283 175 13 and and CC cord-333672-ef53l283 175 14 permeability permeability NN cord-333672-ef53l283 175 15 , , , cord-333672-ef53l283 175 16 as as RB cord-333672-ef53l283 175 17 well well RB cord-333672-ef53l283 175 18 as as IN cord-333672-ef53l283 175 19 endotoxaemia endotoxaemia NN cord-333672-ef53l283 175 20 ( ( -LRB- cord-333672-ef53l283 175 21 78 78 CD cord-333672-ef53l283 175 22 , , , cord-333672-ef53l283 175 23 81 81 CD cord-333672-ef53l283 175 24 ) ) -RRB- cord-333672-ef53l283 175 25 , , , cord-333672-ef53l283 175 26 if if IN cord-333672-ef53l283 175 27 translatable translatable JJ cord-333672-ef53l283 175 28 to to IN cord-333672-ef53l283 175 29 humans human NNS cord-333672-ef53l283 176 1 these these DT cord-333672-ef53l283 176 2 results result NNS cord-333672-ef53l283 176 3 suggest suggest VBP cord-333672-ef53l283 176 4 that that IN cord-333672-ef53l283 176 5 shift shift JJ cord-333672-ef53l283 176 6 workers worker NNS cord-333672-ef53l283 176 7 who who WP cord-333672-ef53l283 176 8 follow follow VBP cord-333672-ef53l283 176 9 a a DT cord-333672-ef53l283 176 10 KD KD NNP cord-333672-ef53l283 176 11 may may MD cord-333672-ef53l283 176 12 protect protect VB cord-333672-ef53l283 176 13 themselves -PRON- PRP cord-333672-ef53l283 176 14 against against IN cord-333672-ef53l283 176 15 some some DT cord-333672-ef53l283 176 16 of of IN cord-333672-ef53l283 176 17 the the DT cord-333672-ef53l283 176 18 adverse adverse JJ cord-333672-ef53l283 176 19 consequences consequence NNS cord-333672-ef53l283 176 20 of of IN cord-333672-ef53l283 176 21 consuming consume VBG cord-333672-ef53l283 176 22 calories calorie NNS cord-333672-ef53l283 176 23 at at IN cord-333672-ef53l283 176 24 suboptimal suboptimal JJ cord-333672-ef53l283 176 25 circadian circadian NN cord-333672-ef53l283 176 26 phases phase NNS cord-333672-ef53l283 176 27 . . . cord-333672-ef53l283 177 1 More more RBR cord-333672-ef53l283 177 2 generally generally RB cord-333672-ef53l283 177 3 , , , cord-333672-ef53l283 177 4 both both CC cord-333672-ef53l283 177 5 the the DT cord-333672-ef53l283 177 6 KD KD NNP cord-333672-ef53l283 177 7 and and CC cord-333672-ef53l283 177 8 less less RBR cord-333672-ef53l283 177 9 severe severe JJ cord-333672-ef53l283 177 10 carbohydrate carbohydrate NN cord-333672-ef53l283 177 11 restriction restriction NN cord-333672-ef53l283 177 12 may may MD cord-333672-ef53l283 177 13 reduce reduce VB cord-333672-ef53l283 177 14 some some DT cord-333672-ef53l283 177 15 negative negative JJ cord-333672-ef53l283 177 16 effects effect NNS cord-333672-ef53l283 177 17 of of IN cord-333672-ef53l283 177 18 shift shift NN cord-333672-ef53l283 177 19 work work NN cord-333672-ef53l283 177 20 on on IN cord-333672-ef53l283 177 21 metabolic metabolic JJ cord-333672-ef53l283 177 22 health health NN cord-333672-ef53l283 177 23 . . . cord-333672-ef53l283 178 1 Shift shift JJ cord-333672-ef53l283 178 2 workers worker NNS cord-333672-ef53l283 178 3 are be VBP cord-333672-ef53l283 178 4 at at IN cord-333672-ef53l283 178 5 an an DT cord-333672-ef53l283 178 6 increased increase VBN cord-333672-ef53l283 178 7 risk risk NN cord-333672-ef53l283 178 8 of of IN cord-333672-ef53l283 178 9 impaired impaired JJ cord-333672-ef53l283 178 10 glucose glucose NN cord-333672-ef53l283 178 11 tolerance tolerance NN cord-333672-ef53l283 178 12 and and CC cord-333672-ef53l283 178 13 type type NN cord-333672-ef53l283 178 14 - - HYPH cord-333672-ef53l283 178 15 two two CD cord-333672-ef53l283 178 16 diabetes diabete NNS cord-333672-ef53l283 178 17 , , , cord-333672-ef53l283 178 18 and and CC cord-333672-ef53l283 178 19 restricting restrict VBG cord-333672-ef53l283 178 20 carbohydrate carbohydrate NN cord-333672-ef53l283 178 21 intake intake NN cord-333672-ef53l283 178 22 is be VBZ cord-333672-ef53l283 178 23 likely likely JJ cord-333672-ef53l283 178 24 to to TO cord-333672-ef53l283 178 25 reduce reduce VB cord-333672-ef53l283 178 26 fasting fast VBG cord-333672-ef53l283 178 27 and and CC cord-333672-ef53l283 178 28 postprandial postprandial JJ cord-333672-ef53l283 178 29 glycaemia glycaemia NN cord-333672-ef53l283 178 30 , , , cord-333672-ef53l283 178 31 both both DT cord-333672-ef53l283 178 32 of of IN cord-333672-ef53l283 178 33 which which WDT cord-333672-ef53l283 178 34 are be VBP cord-333672-ef53l283 178 35 precursory precursory JJ cord-333672-ef53l283 178 36 to to IN cord-333672-ef53l283 178 37 numerous numerous JJ cord-333672-ef53l283 178 38 chronic chronic JJ cord-333672-ef53l283 178 39 diseases disease NNS cord-333672-ef53l283 178 40 ( ( -LRB- cord-333672-ef53l283 178 41 e.g. e.g. RB cord-333672-ef53l283 178 42 , , , cord-333672-ef53l283 178 43 some some DT cord-333672-ef53l283 178 44 cardiovascular cardiovascular JJ cord-333672-ef53l283 178 45 diseases disease NNS cord-333672-ef53l283 178 46 , , , cord-333672-ef53l283 178 47 certain certain JJ cord-333672-ef53l283 178 48 cancers cancer NNS cord-333672-ef53l283 178 49 , , , cord-333672-ef53l283 178 50 and and CC cord-333672-ef53l283 178 51 dementia dementia NN cord-333672-ef53l283 178 52 ) ) -RRB- cord-333672-ef53l283 178 53 ( ( -LRB- cord-333672-ef53l283 178 54 82 82 CD cord-333672-ef53l283 178 55 ) ) -RRB- cord-333672-ef53l283 179 1 ( ( -LRB- cord-333672-ef53l283 179 2 83 83 CD cord-333672-ef53l283 179 3 ) ) -RRB- cord-333672-ef53l283 180 1 ( ( -LRB- cord-333672-ef53l283 180 2 84 84 CD cord-333672-ef53l283 180 3 ) ) -RRB- cord-333672-ef53l283 180 4 ( ( -LRB- cord-333672-ef53l283 180 5 85 85 CD cord-333672-ef53l283 180 6 ) ) -RRB- cord-333672-ef53l283 180 7 ( ( -LRB- cord-333672-ef53l283 180 8 86 86 CD cord-333672-ef53l283 180 9 ) ) -RRB- cord-333672-ef53l283 180 10 ( ( -LRB- cord-333672-ef53l283 180 11 87 87 CD cord-333672-ef53l283 180 12 ) ) -RRB- cord-333672-ef53l283 180 13 . . . cord-333672-ef53l283 181 1 Preliminary preliminary JJ cord-333672-ef53l283 181 2 evidence evidence NN cord-333672-ef53l283 181 3 has have VBZ cord-333672-ef53l283 181 4 shown show VBN cord-333672-ef53l283 181 5 that that IN cord-333672-ef53l283 181 6 a a DT cord-333672-ef53l283 181 7 multicomponent multicomponent JJ cord-333672-ef53l283 181 8 lifestyle lifestyle NN cord-333672-ef53l283 181 9 intervention intervention NN cord-333672-ef53l283 181 10 centred centre VBN cord-333672-ef53l283 181 11 on on IN cord-333672-ef53l283 181 12 the the DT cord-333672-ef53l283 181 13 KD KD NNP cord-333672-ef53l283 181 14 may may MD cord-333672-ef53l283 181 15 also also RB cord-333672-ef53l283 181 16 improve improve VB cord-333672-ef53l283 181 17 subjective subjective JJ cord-333672-ef53l283 181 18 sleep sleep NN cord-333672-ef53l283 181 19 quality quality NN cord-333672-ef53l283 181 20 in in IN cord-333672-ef53l283 181 21 adults adult NNS cord-333672-ef53l283 181 22 who who WP cord-333672-ef53l283 181 23 have have VBP cord-333672-ef53l283 181 24 poor poor JJ cord-333672-ef53l283 181 25 glycaemic glycaemic JJ cord-333672-ef53l283 181 26 control control NN cord-333672-ef53l283 181 27 ( ( -LRB- cord-333672-ef53l283 181 28 88 88 CD cord-333672-ef53l283 181 29 ) ) -RRB- cord-333672-ef53l283 181 30 , , , cord-333672-ef53l283 181 31 suggesting suggest VBG cord-333672-ef53l283 181 32 that that IN cord-333672-ef53l283 181 33 sleep sleep NN cord-333672-ef53l283 181 34 enhancement enhancement NN cord-333672-ef53l283 181 35 may may MD cord-333672-ef53l283 181 36 mediate mediate VB cord-333672-ef53l283 181 37 some some DT cord-333672-ef53l283 181 38 of of IN cord-333672-ef53l283 181 39 the the DT cord-333672-ef53l283 181 40 reported report VBN cord-333672-ef53l283 181 41 benefits benefit NNS cord-333672-ef53l283 181 42 of of IN cord-333672-ef53l283 181 43 the the DT cord-333672-ef53l283 181 44 KD KD NNP cord-333672-ef53l283 181 45 . . . cord-333672-ef53l283 182 1 In in IN cord-333672-ef53l283 182 2 preclinical preclinical JJ cord-333672-ef53l283 182 3 studies study NNS cord-333672-ef53l283 182 4 , , , cord-333672-ef53l283 182 5 ketone ketone NN cord-333672-ef53l283 182 6 bodies body NNS cord-333672-ef53l283 182 7 themselves -PRON- PRP cord-333672-ef53l283 182 8 have have VBP cord-333672-ef53l283 182 9 been be VBN cord-333672-ef53l283 182 10 found find VBN cord-333672-ef53l283 182 11 to to TO cord-333672-ef53l283 182 12 have have VB cord-333672-ef53l283 182 13 pleiotropic pleiotropic JJ cord-333672-ef53l283 182 14 beneficial beneficial JJ cord-333672-ef53l283 182 15 physiological physiological JJ cord-333672-ef53l283 182 16 effects effect NNS cord-333672-ef53l283 182 17 , , , cord-333672-ef53l283 182 18 including include VBG cord-333672-ef53l283 182 19 modulation modulation NN cord-333672-ef53l283 182 20 of of IN cord-333672-ef53l283 182 21 inflammation inflammation NN cord-333672-ef53l283 182 22 , , , cord-333672-ef53l283 182 23 tissue tissue NN cord-333672-ef53l283 182 24 - - HYPH cord-333672-ef53l283 182 25 specific specific JJ cord-333672-ef53l283 182 26 suppression suppression NN cord-333672-ef53l283 182 27 of of IN cord-333672-ef53l283 182 28 mTOR mTOR NNP cord-333672-ef53l283 182 29 signalling signalling NN cord-333672-ef53l283 182 30 , , , cord-333672-ef53l283 182 31 and and CC cord-333672-ef53l283 182 32 increased increase VBN cord-333672-ef53l283 182 33 production production NN cord-333672-ef53l283 182 34 of of IN cord-333672-ef53l283 182 35 brain brain NN cord-333672-ef53l283 182 36 - - HYPH cord-333672-ef53l283 182 37 derived derive VBN cord-333672-ef53l283 182 38 neurotrophic neurotrophic NN cord-333672-ef53l283 182 39 factor factor NN cord-333672-ef53l283 182 40 ( ( -LRB- cord-333672-ef53l283 182 41 89 89 CD cord-333672-ef53l283 182 42 ) ) -RRB- cord-333672-ef53l283 182 43 ( ( -LRB- cord-333672-ef53l283 182 44 90 90 CD cord-333672-ef53l283 182 45 ) ) -RRB- cord-333672-ef53l283 182 46 ( ( -LRB- cord-333672-ef53l283 182 47 91 91 CD cord-333672-ef53l283 182 48 ) ) -RRB- cord-333672-ef53l283 182 49 . . . cord-333672-ef53l283 183 1 If if IN cord-333672-ef53l283 183 2 translatable translatable JJ cord-333672-ef53l283 183 3 to to IN cord-333672-ef53l283 183 4 humans human NNS cord-333672-ef53l283 183 5 , , , cord-333672-ef53l283 183 6 these these DT cord-333672-ef53l283 183 7 systemic systemic JJ cord-333672-ef53l283 183 8 effects effect NNS cord-333672-ef53l283 183 9 of of IN cord-333672-ef53l283 183 10 ketone ketone NN cord-333672-ef53l283 183 11 bodies body NNS cord-333672-ef53l283 183 12 imply imply VBP cord-333672-ef53l283 183 13 that that IN cord-333672-ef53l283 183 14 long long JJ cord-333672-ef53l283 183 15 - - HYPH cord-333672-ef53l283 183 16 term term NN cord-333672-ef53l283 183 17 consumption consumption NN cord-333672-ef53l283 183 18 of of IN cord-333672-ef53l283 183 19 a a DT cord-333672-ef53l283 183 20 KD KD NNP cord-333672-ef53l283 183 21 could could MD cord-333672-ef53l283 183 22 reduce reduce VB cord-333672-ef53l283 183 23 risk risk NN cord-333672-ef53l283 183 24 of of IN cord-333672-ef53l283 183 25 certain certain JJ cord-333672-ef53l283 183 26 cancers cancer NNS cord-333672-ef53l283 183 27 and and CC cord-333672-ef53l283 183 28 neurodegenerative neurodegenerative JJ cord-333672-ef53l283 183 29 diseases disease NNS cord-333672-ef53l283 183 30 such such JJ cord-333672-ef53l283 183 31 as as IN cord-333672-ef53l283 183 32 Alzheimer Alzheimer NNP cord-333672-ef53l283 183 33 's 's POS cord-333672-ef53l283 183 34 in in IN cord-333672-ef53l283 183 35 shift shift NN cord-333672-ef53l283 183 36 workers worker NNS cord-333672-ef53l283 183 37 , , , cord-333672-ef53l283 183 38 particularly particularly RB cord-333672-ef53l283 183 39 those those DT cord-333672-ef53l283 183 40 that that WDT cord-333672-ef53l283 183 41 are be VBP cord-333672-ef53l283 183 42 already already RB cord-333672-ef53l283 183 43 at at IN cord-333672-ef53l283 183 44 increased increase VBN cord-333672-ef53l283 183 45 risk risk NN cord-333672-ef53l283 183 46 ( ( -LRB- cord-333672-ef53l283 183 47 92 92 CD cord-333672-ef53l283 183 48 , , , cord-333672-ef53l283 183 49 93 93 CD cord-333672-ef53l283 183 50 ) ) -RRB- cord-333672-ef53l283 183 51 . . . cord-333672-ef53l283 184 1 Increased increase VBN cord-333672-ef53l283 184 2 production production NN cord-333672-ef53l283 184 3 of of IN cord-333672-ef53l283 184 4 ketone ketone NN cord-333672-ef53l283 184 5 bodies body NNS cord-333672-ef53l283 184 6 may may MD cord-333672-ef53l283 184 7 also also RB cord-333672-ef53l283 184 8 account account VB cord-333672-ef53l283 184 9 for for IN cord-333672-ef53l283 184 10 some some DT cord-333672-ef53l283 184 11 benefits benefit NNS cord-333672-ef53l283 184 12 of of IN cord-333672-ef53l283 184 13 fasting fasting NN cord-333672-ef53l283 184 14 and and CC cord-333672-ef53l283 184 15 TRE TRE NNP cord-333672-ef53l283 184 16 . . . cord-333672-ef53l283 185 1 For for IN cord-333672-ef53l283 185 2 example example NN cord-333672-ef53l283 185 3 , , , cord-333672-ef53l283 185 4 early early JJ cord-333672-ef53l283 185 5 TRE TRE NNP cord-333672-ef53l283 185 6 led lead VBD cord-333672-ef53l283 185 7 to to IN cord-333672-ef53l283 185 8 greater great JJR cord-333672-ef53l283 185 9 morning morning NN cord-333672-ef53l283 185 10 beta beta NN cord-333672-ef53l283 185 11 - - HYPH cord-333672-ef53l283 185 12 hydroxybutyrate hydroxybutyrate NN cord-333672-ef53l283 185 13 levels level NNS cord-333672-ef53l283 185 14 compared compare VBN cord-333672-ef53l283 185 15 to to IN cord-333672-ef53l283 185 16 a a DT cord-333672-ef53l283 185 17 12-h 12-h CD cord-333672-ef53l283 185 18 caloric caloric JJ cord-333672-ef53l283 185 19 period period NN cord-333672-ef53l283 185 20 ( ( -LRB- cord-333672-ef53l283 185 21 59 59 CD cord-333672-ef53l283 185 22 ) ) -RRB- cord-333672-ef53l283 185 23 . . . cord-333672-ef53l283 186 1 However however RB cord-333672-ef53l283 186 2 , , , cord-333672-ef53l283 186 3 there there EX cord-333672-ef53l283 186 4 have have VBP cord-333672-ef53l283 186 5 not not RB cord-333672-ef53l283 186 6 yet yet RB cord-333672-ef53l283 186 7 been be VBN cord-333672-ef53l283 186 8 any any DT cord-333672-ef53l283 186 9 clinical clinical JJ cord-333672-ef53l283 186 10 trials trial NNS cord-333672-ef53l283 186 11 of of IN cord-333672-ef53l283 186 12 the the DT cord-333672-ef53l283 186 13 KD KD NNP cord-333672-ef53l283 186 14 in in IN cord-333672-ef53l283 186 15 shift shift NN cord-333672-ef53l283 186 16 workers worker NNS cord-333672-ef53l283 186 17 , , , cord-333672-ef53l283 186 18 and and CC cord-333672-ef53l283 186 19 it -PRON- PRP cord-333672-ef53l283 186 20 will will MD cord-333672-ef53l283 186 21 be be VB cord-333672-ef53l283 186 22 interesting interesting JJ cord-333672-ef53l283 186 23 to to TO cord-333672-ef53l283 186 24 explore explore VB cord-333672-ef53l283 186 25 how how WRB cord-333672-ef53l283 186 26 the the DT cord-333672-ef53l283 186 27 combination combination NN cord-333672-ef53l283 186 28 of of IN cord-333672-ef53l283 186 29 the the DT cord-333672-ef53l283 186 30 KD KD NNP cord-333672-ef53l283 186 31 and and CC cord-333672-ef53l283 186 32 TRE TRE NNP cord-333672-ef53l283 186 33 and/or and/or CC cord-333672-ef53l283 186 34 intermittent intermittent JJ cord-333672-ef53l283 186 35 fasting fast VBG cord-333672-ef53l283 186 36 interact interact VBP cord-333672-ef53l283 186 37 to to TO cord-333672-ef53l283 186 38 affect affect VB cord-333672-ef53l283 186 39 ketosis ketosis NN cord-333672-ef53l283 186 40 , , , cord-333672-ef53l283 186 41 metabolic metabolic JJ cord-333672-ef53l283 186 42 regulation regulation NN cord-333672-ef53l283 186 43 , , , cord-333672-ef53l283 186 44 and and CC cord-333672-ef53l283 186 45 circadian circadian NN cord-333672-ef53l283 186 46 biology biology NN cord-333672-ef53l283 186 47 in in IN cord-333672-ef53l283 186 48 these these DT cord-333672-ef53l283 186 49 people people NNS cord-333672-ef53l283 186 50 . . . cord-333672-ef53l283 187 1 In in IN cord-333672-ef53l283 187 2 addition addition NN cord-333672-ef53l283 187 3 to to IN cord-333672-ef53l283 187 4 effects effect NNS cord-333672-ef53l283 187 5 of of IN cord-333672-ef53l283 187 6 dietary dietary JJ cord-333672-ef53l283 187 7 patterns pattern NNS cord-333672-ef53l283 187 8 on on IN cord-333672-ef53l283 187 9 the the DT cord-333672-ef53l283 187 10 circadian circadian NN cord-333672-ef53l283 187 11 system system NN cord-333672-ef53l283 187 12 , , , cord-333672-ef53l283 187 13 specific specific JJ cord-333672-ef53l283 187 14 dietary dietary JJ cord-333672-ef53l283 187 15 compounds compound NNS cord-333672-ef53l283 187 16 have have VBP cord-333672-ef53l283 187 17 chronobiotic chronobiotic JJ cord-333672-ef53l283 187 18 actions action NNS cord-333672-ef53l283 187 19 . . . cord-333672-ef53l283 188 1 A a DT cord-333672-ef53l283 188 2 multitude multitude NN cord-333672-ef53l283 188 3 of of IN cord-333672-ef53l283 188 4 dietary dietary JJ cord-333672-ef53l283 188 5 compounds compound NNS cord-333672-ef53l283 188 6 affects affect VBZ cord-333672-ef53l283 188 7 the the DT cord-333672-ef53l283 188 8 circadian circadian NN cord-333672-ef53l283 188 9 system system NN cord-333672-ef53l283 188 10 and and CC cord-333672-ef53l283 188 11 sleep sleep NN cord-333672-ef53l283 188 12 ( ( -LRB- cord-333672-ef53l283 188 13 94 94 CD cord-333672-ef53l283 188 14 , , , cord-333672-ef53l283 188 15 95 95 CD cord-333672-ef53l283 188 16 ) ) -RRB- cord-333672-ef53l283 188 17 , , , cord-333672-ef53l283 188 18 and and CC cord-333672-ef53l283 188 19 it -PRON- PRP cord-333672-ef53l283 188 20 is be VBZ cord-333672-ef53l283 188 21 beyond beyond IN cord-333672-ef53l283 188 22 the the DT cord-333672-ef53l283 188 23 scope scope NN cord-333672-ef53l283 188 24 of of IN cord-333672-ef53l283 188 25 this this DT cord-333672-ef53l283 188 26 article article NN cord-333672-ef53l283 188 27 to to TO cord-333672-ef53l283 188 28 discuss discuss VB cord-333672-ef53l283 188 29 them -PRON- PRP cord-333672-ef53l283 188 30 all all DT cord-333672-ef53l283 188 31 . . . cord-333672-ef53l283 189 1 We -PRON- PRP cord-333672-ef53l283 189 2 therefore therefore RB cord-333672-ef53l283 189 3 focus focus VBP cord-333672-ef53l283 189 4 on on IN cord-333672-ef53l283 189 5 some some DT cord-333672-ef53l283 189 6 of of IN cord-333672-ef53l283 189 7 those those DT cord-333672-ef53l283 189 8 that that WDT cord-333672-ef53l283 189 9 we -PRON- PRP cord-333672-ef53l283 189 10 anticipate anticipate VBP cord-333672-ef53l283 189 11 may may MD cord-333672-ef53l283 189 12 be be VB cord-333672-ef53l283 189 13 practical practical JJ cord-333672-ef53l283 189 14 and and CC cord-333672-ef53l283 189 15 beneficial beneficial JJ cord-333672-ef53l283 189 16 for for IN cord-333672-ef53l283 189 17 shift shift NN cord-333672-ef53l283 189 18 workers worker NNS cord-333672-ef53l283 189 19 . . . cord-333672-ef53l283 190 1 In in IN cord-333672-ef53l283 190 2 the the DT cord-333672-ef53l283 190 3 future future NN cord-333672-ef53l283 190 4 , , , cord-333672-ef53l283 190 5 screens screen NNS cord-333672-ef53l283 190 6 for for IN cord-333672-ef53l283 190 7 novel novel NN cord-333672-ef53l283 190 8 chronobiotics chronobiotic NNS cord-333672-ef53l283 190 9 and and CC cord-333672-ef53l283 190 10 hypnotics hypnotic NNS cord-333672-ef53l283 190 11 may may MD cord-333672-ef53l283 190 12 yield yield VB cord-333672-ef53l283 190 13 compounds compound NNS cord-333672-ef53l283 190 14 that that WDT cord-333672-ef53l283 190 15 support support VBP cord-333672-ef53l283 190 16 the the DT cord-333672-ef53l283 190 17 health health NN cord-333672-ef53l283 190 18 and and CC cord-333672-ef53l283 190 19 performance performance NN cord-333672-ef53l283 190 20 of of IN cord-333672-ef53l283 190 21 these these DT cord-333672-ef53l283 190 22 workers worker NNS cord-333672-ef53l283 190 23 ( ( -LRB- cord-333672-ef53l283 190 24 96 96 CD cord-333672-ef53l283 190 25 ) ) -RRB- cord-333672-ef53l283 190 26 . . . cord-333672-ef53l283 191 1 Identifying identify VBG cord-333672-ef53l283 191 2 agents agent NNS cord-333672-ef53l283 191 3 that that WDT cord-333672-ef53l283 191 4 counter counter VBP cord-333672-ef53l283 191 5 decrements decrement VBZ cord-333672-ef53l283 191 6 in in IN cord-333672-ef53l283 191 7 health health NN cord-333672-ef53l283 191 8 and and CC cord-333672-ef53l283 191 9 cognitive cognitive JJ cord-333672-ef53l283 191 10 function function NN cord-333672-ef53l283 191 11 incited incite VBN cord-333672-ef53l283 191 12 by by IN cord-333672-ef53l283 191 13 sleep sleep NN cord-333672-ef53l283 191 14 disruption disruption NN cord-333672-ef53l283 191 15 would would MD cord-333672-ef53l283 191 16 also also RB cord-333672-ef53l283 191 17 benefit benefit VB cord-333672-ef53l283 191 18 shift shift NN cord-333672-ef53l283 191 19 workers worker NNS cord-333672-ef53l283 191 20 . . . cord-333672-ef53l283 192 1 Largely largely RB cord-333672-ef53l283 192 2 by by IN cord-333672-ef53l283 192 3 antagonising antagonise VBG cord-333672-ef53l283 192 4 adenosine adenosine NN cord-333672-ef53l283 192 5 receptors receptor NNS cord-333672-ef53l283 192 6 , , , cord-333672-ef53l283 192 7 consumption consumption NN cord-333672-ef53l283 192 8 of of IN cord-333672-ef53l283 192 9 caffeine caffeine NN cord-333672-ef53l283 192 10 can can MD cord-333672-ef53l283 192 11 improve improve VB cord-333672-ef53l283 192 12 alertness alertness NN cord-333672-ef53l283 192 13 , , , cord-333672-ef53l283 192 14 attention attention NN cord-333672-ef53l283 192 15 , , , cord-333672-ef53l283 192 16 reaction reaction NN cord-333672-ef53l283 192 17 time time NN cord-333672-ef53l283 192 18 , , , cord-333672-ef53l283 192 19 and and CC cord-333672-ef53l283 192 20 mood mood NN cord-333672-ef53l283 192 21 , , , cord-333672-ef53l283 192 22 as as RB cord-333672-ef53l283 192 23 well well RB cord-333672-ef53l283 192 24 as as IN cord-333672-ef53l283 192 25 physical physical JJ cord-333672-ef53l283 192 26 performance performance NN cord-333672-ef53l283 192 27 in in IN cord-333672-ef53l283 192 28 tests test NNS cord-333672-ef53l283 192 29 of of IN cord-333672-ef53l283 192 30 endurance endurance NN cord-333672-ef53l283 192 31 , , , cord-333672-ef53l283 192 32 strength strength NN cord-333672-ef53l283 192 33 , , , cord-333672-ef53l283 192 34 and and CC cord-333672-ef53l283 192 35 power power NN cord-333672-ef53l283 192 36 ( ( -LRB- cord-333672-ef53l283 192 37 44 44 CD cord-333672-ef53l283 192 38 ) ) -RRB- cord-333672-ef53l283 192 39 . . . cord-333672-ef53l283 193 1 Studies study NNS cord-333672-ef53l283 193 2 of of IN cord-333672-ef53l283 193 3 caffeine caffeine NN cord-333672-ef53l283 193 4 consumption consumption NN cord-333672-ef53l283 193 5 by by IN cord-333672-ef53l283 193 6 shift shift NN cord-333672-ef53l283 193 7 workers worker NNS cord-333672-ef53l283 193 8 have have VBP cord-333672-ef53l283 193 9 consistently consistently RB cord-333672-ef53l283 193 10 shown show VBN cord-333672-ef53l283 193 11 beneficial beneficial JJ cord-333672-ef53l283 193 12 effects effect NNS cord-333672-ef53l283 193 13 on on IN cord-333672-ef53l283 193 14 multiple multiple JJ cord-333672-ef53l283 193 15 aspects aspect NNS cord-333672-ef53l283 193 16 of of IN cord-333672-ef53l283 193 17 cognitive cognitive JJ cord-333672-ef53l283 193 18 function function NN cord-333672-ef53l283 193 19 , , , cord-333672-ef53l283 193 20 although although IN cord-333672-ef53l283 193 21 whether whether IN cord-333672-ef53l283 193 22 this this DT cord-333672-ef53l283 193 23 results result NNS cord-333672-ef53l283 193 24 in in IN cord-333672-ef53l283 193 25 improved improved JJ cord-333672-ef53l283 193 26 safety safety NN cord-333672-ef53l283 193 27 is be VBZ cord-333672-ef53l283 193 28 not not RB cord-333672-ef53l283 193 29 clear clear JJ cord-333672-ef53l283 193 30 ( ( -LRB- cord-333672-ef53l283 193 31 97 97 CD cord-333672-ef53l283 193 32 ) ) -RRB- cord-333672-ef53l283 193 33 . . . cord-333672-ef53l283 194 1 The the DT cord-333672-ef53l283 194 2 trade trade NN cord-333672-ef53l283 194 3 - - HYPH cord-333672-ef53l283 194 4 off off NN cord-333672-ef53l283 194 5 is be VBZ cord-333672-ef53l283 194 6 that that IN cord-333672-ef53l283 194 7 caffeine caffeine NN cord-333672-ef53l283 194 8 consumption consumption NN cord-333672-ef53l283 194 9 tends tend VBZ cord-333672-ef53l283 194 10 to to TO cord-333672-ef53l283 194 11 prolong prolong VB cord-333672-ef53l283 194 12 sleep sleep NN cord-333672-ef53l283 194 13 latency latency NN cord-333672-ef53l283 194 14 , , , cord-333672-ef53l283 194 15 reduce reduce VB cord-333672-ef53l283 194 16 slow slow JJ cord-333672-ef53l283 194 17 - - HYPH cord-333672-ef53l283 194 18 wave wave NN cord-333672-ef53l283 194 19 activity activity NN cord-333672-ef53l283 194 20 during during IN cord-333672-ef53l283 194 21 sleep sleep NN cord-333672-ef53l283 194 22 ( ( -LRB- cord-333672-ef53l283 194 23 which which WDT cord-333672-ef53l283 194 24 is be VBZ cord-333672-ef53l283 194 25 important important JJ cord-333672-ef53l283 194 26 to to IN cord-333672-ef53l283 194 27 numerous numerous JJ cord-333672-ef53l283 194 28 restorative restorative JJ cord-333672-ef53l283 194 29 processes process NNS cord-333672-ef53l283 194 30 ) ) -RRB- cord-333672-ef53l283 194 31 , , , cord-333672-ef53l283 194 32 shorten shorten VB cord-333672-ef53l283 194 33 sleep sleep NN cord-333672-ef53l283 194 34 duration duration NN cord-333672-ef53l283 194 35 , , , cord-333672-ef53l283 194 36 fragment fragment NN cord-333672-ef53l283 194 37 sleep sleep NN cord-333672-ef53l283 194 38 , , , cord-333672-ef53l283 194 39 and and CC cord-333672-ef53l283 194 40 worsen worsen VB cord-333672-ef53l283 194 41 subjective subjective JJ cord-333672-ef53l283 194 42 sleep sleep NN cord-333672-ef53l283 194 43 quality quality NN cord-333672-ef53l283 194 44 ( ( -LRB- cord-333672-ef53l283 194 45 98 98 CD cord-333672-ef53l283 194 46 ) ) -RRB- cord-333672-ef53l283 194 47 . . . cord-333672-ef53l283 195 1 Consumed consume VBN cord-333672-ef53l283 195 2 late late RB cord-333672-ef53l283 195 3 in in IN cord-333672-ef53l283 195 4 the the DT cord-333672-ef53l283 195 5 day day NN cord-333672-ef53l283 195 6 as as IN cord-333672-ef53l283 195 7 coffee coffee NN cord-333672-ef53l283 195 8 , , , cord-333672-ef53l283 195 9 caffeine caffeine NN cord-333672-ef53l283 195 10 also also RB cord-333672-ef53l283 195 11 delays delay VBZ cord-333672-ef53l283 195 12 circadian circadian NN cord-333672-ef53l283 195 13 phase phase NN cord-333672-ef53l283 195 14 ( ( -LRB- cord-333672-ef53l283 195 15 99 99 CD cord-333672-ef53l283 195 16 ) ) -RRB- cord-333672-ef53l283 195 17 . . . cord-333672-ef53l283 196 1 Thus thus RB cord-333672-ef53l283 196 2 it -PRON- PRP cord-333672-ef53l283 196 3 is be VBZ cord-333672-ef53l283 196 4 clear clear JJ cord-333672-ef53l283 196 5 that that IN cord-333672-ef53l283 196 6 while while IN cord-333672-ef53l283 196 7 judicious judicious JJ cord-333672-ef53l283 196 8 caffeine caffeine NN cord-333672-ef53l283 196 9 intake intake NN cord-333672-ef53l283 196 10 can can MD cord-333672-ef53l283 196 11 be be VB cord-333672-ef53l283 196 12 used use VBN cord-333672-ef53l283 196 13 to to TO cord-333672-ef53l283 196 14 help help VB cord-333672-ef53l283 196 15 shift shift VB cord-333672-ef53l283 196 16 workers worker NNS cord-333672-ef53l283 196 17 perform perform VB cord-333672-ef53l283 196 18 at at IN cord-333672-ef53l283 196 19 work work NN cord-333672-ef53l283 196 20 -especially -especially RB cord-333672-ef53l283 196 21 when when WRB cord-333672-ef53l283 196 22 sleepy sleepy JJ cord-333672-ef53l283 196 23 -mistimed -mistimed JJ cord-333672-ef53l283 196 24 caffeine caffeine NN cord-333672-ef53l283 196 25 intake intake NN cord-333672-ef53l283 196 26 may may MD cord-333672-ef53l283 196 27 strongly strongly RB cord-333672-ef53l283 196 28 degrade degrade VB cord-333672-ef53l283 196 29 sleep sleep NN cord-333672-ef53l283 196 30 , , , cord-333672-ef53l283 196 31 which which WDT cord-333672-ef53l283 196 32 is be VBZ cord-333672-ef53l283 196 33 noteworthy noteworthy JJ cord-333672-ef53l283 196 34 given give VBN cord-333672-ef53l283 196 35 that that IN cord-333672-ef53l283 196 36 many many JJ cord-333672-ef53l283 196 37 of of IN cord-333672-ef53l283 196 38 the the DT cord-333672-ef53l283 196 39 adverse adverse JJ cord-333672-ef53l283 196 40 consequences consequence NNS cord-333672-ef53l283 196 41 of of IN cord-333672-ef53l283 196 42 shift shift NN cord-333672-ef53l283 196 43 work work NN cord-333672-ef53l283 196 44 appear appear VBP cord-333672-ef53l283 196 45 to to TO cord-333672-ef53l283 196 46 relate relate VB cord-333672-ef53l283 196 47 to to IN cord-333672-ef53l283 196 48 its -PRON- PRP$ cord-333672-ef53l283 196 49 detrimental detrimental JJ cord-333672-ef53l283 196 50 effects effect NNS cord-333672-ef53l283 196 51 on on IN cord-333672-ef53l283 196 52 sleep sleep NN cord-333672-ef53l283 196 53 ( ( -LRB- cord-333672-ef53l283 196 54 5 5 CD cord-333672-ef53l283 196 55 ) ) -RRB- cord-333672-ef53l283 196 56 . . . cord-333672-ef53l283 197 1 It -PRON- PRP cord-333672-ef53l283 197 2 therefore therefore RB cord-333672-ef53l283 197 3 seems seem VBZ cord-333672-ef53l283 197 4 prudent prudent JJ cord-333672-ef53l283 197 5 to to TO cord-333672-ef53l283 197 6 recommend recommend VB cord-333672-ef53l283 197 7 that that IN cord-333672-ef53l283 197 8 shift shift NN cord-333672-ef53l283 197 9 workers worker NNS cord-333672-ef53l283 197 10 generally generally RB cord-333672-ef53l283 197 11 stop stop VBP cord-333672-ef53l283 197 12 consuming consume VBG cord-333672-ef53l283 197 13 caffeine caffeine NN cord-333672-ef53l283 197 14 several several JJ cord-333672-ef53l283 197 15 hours hour NNS cord-333672-ef53l283 197 16 before before IN cord-333672-ef53l283 197 17 their -PRON- PRP$ cord-333672-ef53l283 197 18 main main JJ cord-333672-ef53l283 197 19 sleep sleep NN cord-333672-ef53l283 197 20 period period NN cord-333672-ef53l283 197 21 ( ( -LRB- cord-333672-ef53l283 197 22 more more RBR cord-333672-ef53l283 197 23 specific specific JJ cord-333672-ef53l283 197 24 guidance guidance NN cord-333672-ef53l283 197 25 on on IN cord-333672-ef53l283 197 26 caffeine caffeine NN cord-333672-ef53l283 197 27 intake intake NN cord-333672-ef53l283 197 28 is be VBZ cord-333672-ef53l283 197 29 provided provide VBN cord-333672-ef53l283 197 30 in in IN cord-333672-ef53l283 197 31 Table Table NNP cord-333672-ef53l283 197 32 1 1 CD cord-333672-ef53l283 197 33 ) ) -RRB- cord-333672-ef53l283 197 34 . . . cord-333672-ef53l283 198 1 Antagonising antagonising NN cord-333672-ef53l283 198 2 adenosine adenosine NN cord-333672-ef53l283 198 3 receptors receptor NNS cord-333672-ef53l283 198 4 is be VBZ cord-333672-ef53l283 198 5 one one CD cord-333672-ef53l283 198 6 way way NN cord-333672-ef53l283 198 7 to to TO cord-333672-ef53l283 198 8 reduce reduce VB cord-333672-ef53l283 198 9 the the DT cord-333672-ef53l283 198 10 accumulation accumulation NN cord-333672-ef53l283 198 11 of of IN cord-333672-ef53l283 198 12 pressure pressure NN cord-333672-ef53l283 198 13 to to TO cord-333672-ef53l283 198 14 sleep sleep VB cord-333672-ef53l283 198 15 ( ( -LRB- cord-333672-ef53l283 198 16 sleep sleep NN cord-333672-ef53l283 198 17 homeostasis homeostasis NN cord-333672-ef53l283 198 18 ) ) -RRB- cord-333672-ef53l283 198 19 , , , cord-333672-ef53l283 198 20 but but CC cord-333672-ef53l283 198 21 another another DT cord-333672-ef53l283 198 22 is be VBZ cord-333672-ef53l283 198 23 to to TO cord-333672-ef53l283 198 24 bolster bolster VB cord-333672-ef53l283 198 25 the the DT cord-333672-ef53l283 198 26 phosphorylation phosphorylation NN cord-333672-ef53l283 198 27 of of IN cord-333672-ef53l283 198 28 adenosine adenosine NN cord-333672-ef53l283 198 29 . . . cord-333672-ef53l283 199 1 Creatine creatine NN cord-333672-ef53l283 199 2 ( ( -LRB- cord-333672-ef53l283 199 3 creatine creatine NN cord-333672-ef53l283 199 4 monohydrate monohydrate NN cord-333672-ef53l283 199 5 , , , cord-333672-ef53l283 199 6 specifically specifically RB cord-333672-ef53l283 199 7 ) ) -RRB- cord-333672-ef53l283 199 8 , , , cord-333672-ef53l283 199 9 a a DT cord-333672-ef53l283 199 10 safe safe JJ cord-333672-ef53l283 199 11 and and CC cord-333672-ef53l283 199 12 inexpensive inexpensive JJ cord-333672-ef53l283 199 13 dietary dietary JJ cord-333672-ef53l283 199 14 supplement supplement NN cord-333672-ef53l283 199 15 that that WDT cord-333672-ef53l283 199 16 increases increase VBZ cord-333672-ef53l283 199 17 brain brain NN cord-333672-ef53l283 199 18 phosphocreatine phosphocreatine NN cord-333672-ef53l283 199 19 stores store NNS cord-333672-ef53l283 199 20 , , , cord-333672-ef53l283 199 21 countering counter VBG cord-333672-ef53l283 199 22 the the DT cord-333672-ef53l283 199 23 accumulation accumulation NN cord-333672-ef53l283 199 24 of of IN cord-333672-ef53l283 199 25 extracellular extracellular JJ cord-333672-ef53l283 199 26 adenosine adenosine NN cord-333672-ef53l283 199 27 in in IN cord-333672-ef53l283 199 28 the the DT cord-333672-ef53l283 199 29 brain brain NN cord-333672-ef53l283 199 30 during during IN cord-333672-ef53l283 199 31 extended extended JJ cord-333672-ef53l283 199 32 wakefulness wakefulness NN cord-333672-ef53l283 199 33 . . . cord-333672-ef53l283 200 1 A a DT cord-333672-ef53l283 200 2 study study NN cord-333672-ef53l283 200 3 of of IN cord-333672-ef53l283 200 4 rats rat NNS cord-333672-ef53l283 200 5 showed show VBD cord-333672-ef53l283 200 6 that that IN cord-333672-ef53l283 200 7 adding add VBG cord-333672-ef53l283 200 8 creatine creatine NN cord-333672-ef53l283 200 9 to to IN cord-333672-ef53l283 200 10 the the DT cord-333672-ef53l283 200 11 rats rat NNS cord-333672-ef53l283 200 12 ' ' POS cord-333672-ef53l283 200 13 chow chow NN cord-333672-ef53l283 200 14 for for IN cord-333672-ef53l283 200 15 4 4 CD cord-333672-ef53l283 200 16 weeks week NNS cord-333672-ef53l283 200 17 reduced reduce VBD cord-333672-ef53l283 200 18 the the DT cord-333672-ef53l283 200 19 duration duration NN cord-333672-ef53l283 200 20 and and CC cord-333672-ef53l283 200 21 slow slow JJ cord-333672-ef53l283 200 22 - - HYPH cord-333672-ef53l283 200 23 wave wave NN cord-333672-ef53l283 200 24 activity activity NN cord-333672-ef53l283 200 25 of of IN cord-333672-ef53l283 200 26 the the DT cord-333672-ef53l283 200 27 rats rat NNS cord-333672-ef53l283 200 28 ' ' POS cord-333672-ef53l283 200 29 sleep sleep NN cord-333672-ef53l283 200 30 ( ( -LRB- cord-333672-ef53l283 200 31 100 100 CD cord-333672-ef53l283 200 32 ) ) -RRB- cord-333672-ef53l283 200 33 . . . cord-333672-ef53l283 201 1 We -PRON- PRP cord-333672-ef53l283 201 2 do do VBP cord-333672-ef53l283 201 3 not not RB cord-333672-ef53l283 201 4 currently currently RB cord-333672-ef53l283 201 5 know know VB cord-333672-ef53l283 201 6 the the DT cord-333672-ef53l283 201 7 effects effect NNS cord-333672-ef53l283 201 8 of of IN cord-333672-ef53l283 201 9 creatine creatine NN cord-333672-ef53l283 201 10 supplementation supplementation NN cord-333672-ef53l283 201 11 on on IN cord-333672-ef53l283 201 12 sleep sleep NN cord-333672-ef53l283 201 13 in in IN cord-333672-ef53l283 201 14 humans human NNS cord-333672-ef53l283 201 15 , , , cord-333672-ef53l283 201 16 however however RB cord-333672-ef53l283 201 17 . . . cord-333672-ef53l283 202 1 Notably notably RB cord-333672-ef53l283 202 2 , , , cord-333672-ef53l283 202 3 while while IN cord-333672-ef53l283 202 4 shorter short JJR cord-333672-ef53l283 202 5 sleep sleep NN cord-333672-ef53l283 202 6 would would MD cord-333672-ef53l283 202 7 generally generally RB cord-333672-ef53l283 202 8 be be VB cord-333672-ef53l283 202 9 expected expect VBN cord-333672-ef53l283 202 10 to to TO cord-333672-ef53l283 202 11 impair impair VB cord-333672-ef53l283 202 12 health health NN cord-333672-ef53l283 202 13 and and CC cord-333672-ef53l283 202 14 performance performance NN cord-333672-ef53l283 202 15 , , , cord-333672-ef53l283 202 16 creatine creatine NN cord-333672-ef53l283 202 17 supplementation supplementation NN cord-333672-ef53l283 202 18 has have VBZ cord-333672-ef53l283 202 19 repeatedly repeatedly RB cord-333672-ef53l283 202 20 been be VBN cord-333672-ef53l283 202 21 shown show VBN cord-333672-ef53l283 202 22 to to TO cord-333672-ef53l283 202 23 enhance enhance VB cord-333672-ef53l283 202 24 these these DT cord-333672-ef53l283 202 25 variables variable NNS cord-333672-ef53l283 202 26 in in IN cord-333672-ef53l283 202 27 humans human NNS cord-333672-ef53l283 202 28 . . . cord-333672-ef53l283 203 1 Creatine creatine NN cord-333672-ef53l283 203 2 supplementation supplementation NN cord-333672-ef53l283 203 3 routinely routinely RB cord-333672-ef53l283 203 4 improves improve VBZ cord-333672-ef53l283 203 5 performance performance NN cord-333672-ef53l283 203 6 in in IN cord-333672-ef53l283 203 7 -and -and : cord-333672-ef53l283 203 8 adaptations adaptation NNS cord-333672-ef53l283 203 9 to to IN cord-333672-ef53l283 203 10 -many -many JJ cord-333672-ef53l283 203 11 exercise exercise NN cord-333672-ef53l283 203 12 tasks task NNS cord-333672-ef53l283 203 13 , , , cord-333672-ef53l283 203 14 and and CC cord-333672-ef53l283 203 15 creatine creatine NN cord-333672-ef53l283 203 16 has have VBZ cord-333672-ef53l283 203 17 a a DT cord-333672-ef53l283 203 18 number number NN cord-333672-ef53l283 203 19 of of IN cord-333672-ef53l283 203 20 therapeutic therapeutic JJ cord-333672-ef53l283 203 21 actions action NNS cord-333672-ef53l283 203 22 , , , cord-333672-ef53l283 203 23 including include VBG cord-333672-ef53l283 203 24 neuroprotective neuroprotective JJ cord-333672-ef53l283 203 25 properties property NNS cord-333672-ef53l283 203 26 ( ( -LRB- cord-333672-ef53l283 203 27 101 101 CD cord-333672-ef53l283 203 28 ) ) -RRB- cord-333672-ef53l283 203 29 . . . cord-333672-ef53l283 204 1 Interestingly interestingly RB cord-333672-ef53l283 204 2 , , , cord-333672-ef53l283 204 3 creatine creatine NN cord-333672-ef53l283 204 4 supplementation supplementation NN cord-333672-ef53l283 204 5 may may MD cord-333672-ef53l283 204 6 also also RB cord-333672-ef53l283 204 7 acutely acutely RB cord-333672-ef53l283 204 8 help help VB cord-333672-ef53l283 204 9 protect protect VB cord-333672-ef53l283 204 10 against against IN cord-333672-ef53l283 204 11 the the DT cord-333672-ef53l283 204 12 deleterious deleterious JJ cord-333672-ef53l283 204 13 consequences consequence NNS cord-333672-ef53l283 204 14 of of IN cord-333672-ef53l283 204 15 sleep sleep NN cord-333672-ef53l283 204 16 loss loss NN cord-333672-ef53l283 204 17 . . . cord-333672-ef53l283 205 1 After after IN cord-333672-ef53l283 205 2 sleep sleep NN cord-333672-ef53l283 205 3 loss loss NN cord-333672-ef53l283 205 4 , , , cord-333672-ef53l283 205 5 creatine creatine NN cord-333672-ef53l283 205 6 supplementation supplementation NN cord-333672-ef53l283 205 7 seems seem VBZ cord-333672-ef53l283 205 8 to to TO cord-333672-ef53l283 205 9 offset offset VB cord-333672-ef53l283 205 10 deterioration deterioration NN cord-333672-ef53l283 205 11 in in IN cord-333672-ef53l283 205 12 executive executive JJ cord-333672-ef53l283 205 13 function function NN cord-333672-ef53l283 205 14 , , , cord-333672-ef53l283 205 15 mood mood NN cord-333672-ef53l283 205 16 , , , cord-333672-ef53l283 205 17 reaction reaction NN cord-333672-ef53l283 205 18 time time NN cord-333672-ef53l283 205 19 , , , cord-333672-ef53l283 205 20 balance balance NN cord-333672-ef53l283 205 21 , , , cord-333672-ef53l283 205 22 and and CC cord-333672-ef53l283 205 23 other other JJ cord-333672-ef53l283 205 24 motor motor NN cord-333672-ef53l283 205 25 skills skill NNS cord-333672-ef53l283 205 26 ( ( -LRB- cord-333672-ef53l283 205 27 102 102 CD cord-333672-ef53l283 205 28 ) ) -RRB- cord-333672-ef53l283 205 29 ( ( -LRB- cord-333672-ef53l283 205 30 103 103 CD cord-333672-ef53l283 205 31 ) ) -RRB- cord-333672-ef53l283 205 32 ( ( -LRB- cord-333672-ef53l283 205 33 104 104 CD cord-333672-ef53l283 205 34 ) ) -RRB- cord-333672-ef53l283 205 35 . . . cord-333672-ef53l283 206 1 Although although IN cord-333672-ef53l283 206 2 we -PRON- PRP cord-333672-ef53l283 206 3 expect expect VBP cord-333672-ef53l283 206 4 creatine creatine NN cord-333672-ef53l283 206 5 supplementation supplementation NN cord-333672-ef53l283 206 6 to to TO cord-333672-ef53l283 206 7 be be VB cord-333672-ef53l283 206 8 a a DT cord-333672-ef53l283 206 9 useful useful JJ cord-333672-ef53l283 206 10 strategy strategy NN cord-333672-ef53l283 206 11 to to TO cord-333672-ef53l283 206 12 help help VB cord-333672-ef53l283 206 13 but but CC cord-333672-ef53l283 206 14 this this DT cord-333672-ef53l283 206 15 people people NNS cord-333672-ef53l283 206 16 cope cope VBP cord-333672-ef53l283 206 17 with with IN cord-333672-ef53l283 206 18 shift shift NN cord-333672-ef53l283 206 19 work work NN cord-333672-ef53l283 206 20 , , , cord-333672-ef53l283 206 21 we -PRON- PRP cord-333672-ef53l283 206 22 are be VBP cord-333672-ef53l283 206 23 not not RB cord-333672-ef53l283 206 24 aware aware JJ cord-333672-ef53l283 206 25 of of IN cord-333672-ef53l283 206 26 any any DT cord-333672-ef53l283 206 27 research research NN cord-333672-ef53l283 206 28 on on IN cord-333672-ef53l283 206 29 this this DT cord-333672-ef53l283 206 30 topic topic NN cord-333672-ef53l283 206 31 . . . cord-333672-ef53l283 207 1 We -PRON- PRP cord-333672-ef53l283 207 2 also also RB cord-333672-ef53l283 207 3 note note VBP cord-333672-ef53l283 207 4 that that IN cord-333672-ef53l283 207 5 there there EX cord-333672-ef53l283 207 6 is be VBZ cord-333672-ef53l283 207 7 some some DT cord-333672-ef53l283 207 8 evidence evidence NN cord-333672-ef53l283 207 9 that that IN cord-333672-ef53l283 207 10 concurrent concurrent JJ cord-333672-ef53l283 207 11 consumption consumption NN cord-333672-ef53l283 207 12 of of IN cord-333672-ef53l283 207 13 caffeine caffeine NN cord-333672-ef53l283 207 14 may may MD cord-333672-ef53l283 207 15 reduce reduce VB cord-333672-ef53l283 207 16 some some DT cord-333672-ef53l283 207 17 of of IN cord-333672-ef53l283 207 18 the the DT cord-333672-ef53l283 207 19 ergogenic ergogenic JJ cord-333672-ef53l283 207 20 effects effect NNS cord-333672-ef53l283 207 21 of of IN cord-333672-ef53l283 207 22 creatine creatine NN cord-333672-ef53l283 207 23 on on IN cord-333672-ef53l283 207 24 physical physical JJ cord-333672-ef53l283 207 25 performance performance NN cord-333672-ef53l283 207 26 ( ( -LRB- cord-333672-ef53l283 207 27 105 105 CD cord-333672-ef53l283 207 28 ) ) -RRB- cord-333672-ef53l283 207 29 , , , cord-333672-ef53l283 207 30 and and CC cord-333672-ef53l283 207 31 additional additional JJ cord-333672-ef53l283 207 32 studies study NNS cord-333672-ef53l283 207 33 are be VBP cord-333672-ef53l283 207 34 needed need VBN cord-333672-ef53l283 207 35 to to TO cord-333672-ef53l283 207 36 better better RB cord-333672-ef53l283 207 37 identify identify VB cord-333672-ef53l283 207 38 how how WRB cord-333672-ef53l283 207 39 the the DT cord-333672-ef53l283 207 40 two two CD cord-333672-ef53l283 207 41 compounds compound NNS cord-333672-ef53l283 207 42 interact interact VBP cord-333672-ef53l283 207 43 . . . cord-333672-ef53l283 208 1 Several several JJ cord-333672-ef53l283 208 2 dietary dietary JJ cord-333672-ef53l283 208 3 amino amino NN cord-333672-ef53l283 208 4 acids acid NNS cord-333672-ef53l283 208 5 may may MD cord-333672-ef53l283 208 6 influence influence VB cord-333672-ef53l283 208 7 circadian circadian NN cord-333672-ef53l283 208 8 rhythms rhythm NNS cord-333672-ef53l283 208 9 and and CC cord-333672-ef53l283 208 10 sleep sleep NN cord-333672-ef53l283 208 11 . . . cord-333672-ef53l283 209 1 For for IN cord-333672-ef53l283 209 2 instance instance NN cord-333672-ef53l283 209 3 , , , cord-333672-ef53l283 209 4 L l NN cord-333672-ef53l283 209 5 - - HYPH cord-333672-ef53l283 209 6 tryptophan tryptophan NN cord-333672-ef53l283 209 7 is be VBZ cord-333672-ef53l283 209 8 a a DT cord-333672-ef53l283 209 9 precursor precursor NN cord-333672-ef53l283 209 10 to to IN cord-333672-ef53l283 209 11 melatonin melatonin NN cord-333672-ef53l283 209 12 that that IN cord-333672-ef53l283 209 13 researchers researcher NNS cord-333672-ef53l283 209 14 have have VBP cord-333672-ef53l283 209 15 studied study VBN cord-333672-ef53l283 209 16 with with IN cord-333672-ef53l283 209 17 respect respect NN cord-333672-ef53l283 209 18 to to IN cord-333672-ef53l283 209 19 circadian circadian NN cord-333672-ef53l283 209 20 rhythms rhythm NNS cord-333672-ef53l283 209 21 and and CC cord-333672-ef53l283 209 22 sleep sleep NN cord-333672-ef53l283 209 23 . . . cord-333672-ef53l283 210 1 As as IN cord-333672-ef53l283 210 2 an an DT cord-333672-ef53l283 210 3 example example NN cord-333672-ef53l283 210 4 , , , cord-333672-ef53l283 210 5 there there EX cord-333672-ef53l283 210 6 appears appear VBZ cord-333672-ef53l283 210 7 to to TO cord-333672-ef53l283 210 8 be be VB cord-333672-ef53l283 210 9 a a DT cord-333672-ef53l283 210 10 temporal temporal JJ cord-333672-ef53l283 210 11 relationship relationship NN cord-333672-ef53l283 210 12 between between IN cord-333672-ef53l283 210 13 consumption consumption NN cord-333672-ef53l283 210 14 of of IN cord-333672-ef53l283 210 15 L l NN cord-333672-ef53l283 210 16 - - HYPH cord-333672-ef53l283 210 17 tryptophan tryptophan NN cord-333672-ef53l283 210 18 in in IN cord-333672-ef53l283 210 19 breast breast NN cord-333672-ef53l283 210 20 milk milk NN cord-333672-ef53l283 210 21 and and CC cord-333672-ef53l283 210 22 infant infant NN cord-333672-ef53l283 210 23 urinary urinary JJ cord-333672-ef53l283 210 24 excretion excretion NN cord-333672-ef53l283 210 25 of of IN cord-333672-ef53l283 210 26 6-sulfatoxymelatonin 6-sulfatoxymelatonin CD cord-333672-ef53l283 210 27 , , , cord-333672-ef53l283 210 28 the the DT cord-333672-ef53l283 210 29 primary primary JJ cord-333672-ef53l283 210 30 metabolite metabolite NN cord-333672-ef53l283 210 31 of of IN cord-333672-ef53l283 210 32 melatonin melatonin NN cord-333672-ef53l283 210 33 ( ( -LRB- cord-333672-ef53l283 210 34 106 106 CD cord-333672-ef53l283 210 35 ) ) -RRB- cord-333672-ef53l283 210 36 . . . cord-333672-ef53l283 211 1 Furthermore furthermore RB cord-333672-ef53l283 211 2 , , , cord-333672-ef53l283 211 3 infants infant NNS cord-333672-ef53l283 211 4 fed feed VBD cord-333672-ef53l283 211 5 L L NNP cord-333672-ef53l283 211 6 - - HYPH cord-333672-ef53l283 211 7 tryptophan tryptophan NN cord-333672-ef53l283 211 8 - - HYPH cord-333672-ef53l283 211 9 enriched enrich VBN cord-333672-ef53l283 211 10 night night NN cord-333672-ef53l283 211 11 - - HYPH cord-333672-ef53l283 211 12 time time NN cord-333672-ef53l283 211 13 formula formula NN cord-333672-ef53l283 211 14 seem seem VBP cord-333672-ef53l283 211 15 to to TO cord-333672-ef53l283 211 16 experience experience VB cord-333672-ef53l283 211 17 more more RBR cord-333672-ef53l283 211 18 consolidated consolidated JJ cord-333672-ef53l283 211 19 sleep sleep NN cord-333672-ef53l283 211 20 / / SYM cord-333672-ef53l283 211 21 wake wake VBP cord-333672-ef53l283 211 22 patterns pattern NNS cord-333672-ef53l283 211 23 ( ( -LRB- cord-333672-ef53l283 211 24 107 107 CD cord-333672-ef53l283 211 25 ) ) -RRB- cord-333672-ef53l283 211 26 . . . cord-333672-ef53l283 212 1 Many many JJ cord-333672-ef53l283 212 2 studies study NNS cord-333672-ef53l283 212 3 of of IN cord-333672-ef53l283 212 4 adults adult NNS cord-333672-ef53l283 212 5 have have VBP cord-333672-ef53l283 212 6 also also RB cord-333672-ef53l283 212 7 shown show VBN cord-333672-ef53l283 212 8 that that IN cord-333672-ef53l283 212 9 ∼ ∼ NN cord-333672-ef53l283 212 10 2 2 CD cord-333672-ef53l283 212 11 g g NNP cord-333672-ef53l283 212 12 L l NN cord-333672-ef53l283 212 13 - - HYPH cord-333672-ef53l283 212 14 tryptophan tryptophan NN cord-333672-ef53l283 212 15 each each DT cord-333672-ef53l283 212 16 day day NN cord-333672-ef53l283 212 17 enhances enhance VBZ cord-333672-ef53l283 212 18 some some DT cord-333672-ef53l283 212 19 sleep sleep NN cord-333672-ef53l283 212 20 parameters parameter NNS cord-333672-ef53l283 212 21 , , , cord-333672-ef53l283 212 22 although although IN cord-333672-ef53l283 212 23 it -PRON- PRP cord-333672-ef53l283 212 24 is be VBZ cord-333672-ef53l283 212 25 not not RB cord-333672-ef53l283 212 26 a a DT cord-333672-ef53l283 212 27 potent potent JJ cord-333672-ef53l283 212 28 hypnotic hypnotic JJ cord-333672-ef53l283 212 29 ( ( -LRB- cord-333672-ef53l283 212 30 108 108 CD cord-333672-ef53l283 212 31 ) ) -RRB- cord-333672-ef53l283 212 32 . . . cord-333672-ef53l283 213 1 To to IN cord-333672-ef53l283 213 2 our -PRON- PRP$ cord-333672-ef53l283 213 3 knowledge knowledge NN cord-333672-ef53l283 213 4 , , , cord-333672-ef53l283 213 5 there there EX cord-333672-ef53l283 213 6 are be VBP cord-333672-ef53l283 213 7 no no RB cord-333672-ef53l283 213 8 rigorously rigorously RB cord-333672-ef53l283 213 9 controlled control VBN cord-333672-ef53l283 213 10 studies study NNS cord-333672-ef53l283 213 11 demonstrating demonstrate VBG cord-333672-ef53l283 213 12 that that IN cord-333672-ef53l283 213 13 L l NN cord-333672-ef53l283 213 14 - - HYPH cord-333672-ef53l283 213 15 tryptophan tryptophan NN cord-333672-ef53l283 213 16 affects affect VBZ cord-333672-ef53l283 213 17 circadian circadian NN cord-333672-ef53l283 213 18 phase phase NN cord-333672-ef53l283 213 19 , , , cord-333672-ef53l283 213 20 however however RB cord-333672-ef53l283 213 21 . . . cord-333672-ef53l283 214 1 Overall overall RB cord-333672-ef53l283 214 2 , , , cord-333672-ef53l283 214 3 there there EX cord-333672-ef53l283 214 4 has have VBZ cord-333672-ef53l283 214 5 been be VBN cord-333672-ef53l283 214 6 little little JJ cord-333672-ef53l283 214 7 research research NN cord-333672-ef53l283 214 8 on on IN cord-333672-ef53l283 214 9 whether whether IN cord-333672-ef53l283 214 10 amino amino JJ cord-333672-ef53l283 214 11 acids acid NNS cord-333672-ef53l283 214 12 affect affect VBP cord-333672-ef53l283 214 13 circadian circadian NN cord-333672-ef53l283 214 14 system system NN cord-333672-ef53l283 214 15 parameters parameter NNS cord-333672-ef53l283 214 16 . . . cord-333672-ef53l283 215 1 In in IN cord-333672-ef53l283 215 2 a a DT cord-333672-ef53l283 215 3 screen screen NN cord-333672-ef53l283 215 4 of of IN cord-333672-ef53l283 215 5 whether whether IN cord-333672-ef53l283 215 6 amino amino JJ cord-333672-ef53l283 215 7 acids acid NNS cord-333672-ef53l283 215 8 affect affect VBP cord-333672-ef53l283 215 9 light light NN cord-333672-ef53l283 215 10 - - HYPH cord-333672-ef53l283 215 11 induced induce VBN cord-333672-ef53l283 215 12 shifts shift NNS cord-333672-ef53l283 215 13 in in IN cord-333672-ef53l283 215 14 the the DT cord-333672-ef53l283 215 15 phase phase NN cord-333672-ef53l283 215 16 of of IN cord-333672-ef53l283 215 17 wheel wheel NN cord-333672-ef53l283 215 18 running running NN cord-333672-ef53l283 215 19 activity activity NN cord-333672-ef53l283 215 20 in in IN cord-333672-ef53l283 215 21 mice mouse NNS cord-333672-ef53l283 215 22 , , , cord-333672-ef53l283 215 23 L l NN cord-333672-ef53l283 215 24 - - HYPH cord-333672-ef53l283 215 25 serine serine NN cord-333672-ef53l283 215 26 increased increase VBD cord-333672-ef53l283 215 27 the the DT cord-333672-ef53l283 215 28 magnitude magnitude NN cord-333672-ef53l283 215 29 of of IN cord-333672-ef53l283 215 30 phase phase NN cord-333672-ef53l283 215 31 shifts shift NNS cord-333672-ef53l283 215 32 by by IN cord-333672-ef53l283 215 33 86 86 CD cord-333672-ef53l283 215 34 % % NN cord-333672-ef53l283 215 35 . . . cord-333672-ef53l283 216 1 This this DT cord-333672-ef53l283 216 2 effect effect NN cord-333672-ef53l283 216 3 seems seem VBZ cord-333672-ef53l283 216 4 to to TO cord-333672-ef53l283 216 5 translate translate VB cord-333672-ef53l283 216 6 to to IN cord-333672-ef53l283 216 7 humans human NNS cord-333672-ef53l283 216 8 , , , cord-333672-ef53l283 216 9 as as IN cord-333672-ef53l283 216 10 adults adult NNS cord-333672-ef53l283 216 11 who who WP cord-333672-ef53l283 216 12 consumed consume VBD cord-333672-ef53l283 216 13 L l NN cord-333672-ef53l283 216 14 - - HYPH cord-333672-ef53l283 216 15 serine serine NN cord-333672-ef53l283 216 16 before before IN cord-333672-ef53l283 216 17 bedtime bedtime NN cord-333672-ef53l283 216 18 experienced experience VBD cord-333672-ef53l283 216 19 a a DT cord-333672-ef53l283 216 20 greater great JJR cord-333672-ef53l283 216 21 advance advance NN cord-333672-ef53l283 216 22 in in IN cord-333672-ef53l283 216 23 circadian circadian NN cord-333672-ef53l283 216 24 phase phase NN cord-333672-ef53l283 216 25 in in IN cord-333672-ef53l283 216 26 response response NN cord-333672-ef53l283 216 27 to to IN cord-333672-ef53l283 216 28 bright bright JJ cord-333672-ef53l283 216 29 light light JJ cord-333672-ef53l283 216 30 exposure exposure NN cord-333672-ef53l283 216 31 ( ( -LRB- cord-333672-ef53l283 216 32 109 109 CD cord-333672-ef53l283 216 33 ) ) -RRB- cord-333672-ef53l283 216 34 . . . cord-333672-ef53l283 217 1 Another another DT cord-333672-ef53l283 217 2 study study NN cord-333672-ef53l283 217 3 reported report VBD cord-333672-ef53l283 217 4 that that IN cord-333672-ef53l283 217 5 1 1 CD cord-333672-ef53l283 217 6 week week NN cord-333672-ef53l283 217 7 of of IN cord-333672-ef53l283 217 8 Lornithine Lornithine NNP cord-333672-ef53l283 217 9 supplementation supplementation NN cord-333672-ef53l283 217 10 delayed delay VBD cord-333672-ef53l283 217 11 the the DT cord-333672-ef53l283 217 12 plasma plasma NN cord-333672-ef53l283 217 13 melatonin melatonin NN cord-333672-ef53l283 217 14 rhythm rhythm NN cord-333672-ef53l283 217 15 by by IN cord-333672-ef53l283 217 16 15 15 CD cord-333672-ef53l283 217 17 min min NN cord-333672-ef53l283 217 18 ( ( -LRB- cord-333672-ef53l283 217 19 110 110 CD cord-333672-ef53l283 217 20 ) ) -RRB- cord-333672-ef53l283 217 21 . . . cord-333672-ef53l283 218 1 However however RB cord-333672-ef53l283 218 2 , , , cord-333672-ef53l283 218 3 LD LD NNP cord-333672-ef53l283 218 4 cycles cycle NNS cord-333672-ef53l283 218 5 and and CC cord-333672-ef53l283 218 6 meal meal NN cord-333672-ef53l283 218 7 timing timing NN cord-333672-ef53l283 218 8 were be VBD cord-333672-ef53l283 218 9 not not RB cord-333672-ef53l283 218 10 fully fully RB cord-333672-ef53l283 218 11 controlled control VBN cord-333672-ef53l283 218 12 in in IN cord-333672-ef53l283 218 13 these these DT cord-333672-ef53l283 218 14 studies study NNS cord-333672-ef53l283 218 15 . . . cord-333672-ef53l283 219 1 Interestingly interestingly RB cord-333672-ef53l283 219 2 , , , cord-333672-ef53l283 219 3 there there EX cord-333672-ef53l283 219 4 is be VBZ cord-333672-ef53l283 219 5 also also RB cord-333672-ef53l283 219 6 preliminary preliminary JJ cord-333672-ef53l283 219 7 evidence evidence NN cord-333672-ef53l283 219 8 that that IN cord-333672-ef53l283 219 9 regular regular JJ cord-333672-ef53l283 219 10 L l NN cord-333672-ef53l283 219 11 - - HYPH cord-333672-ef53l283 219 12 ornithine ornithine NN cord-333672-ef53l283 219 13 supplementation supplementation NN cord-333672-ef53l283 219 14 ( ( -LRB- cord-333672-ef53l283 219 15 400 400 CD cord-333672-ef53l283 219 16 mg mg NN cord-333672-ef53l283 219 17 per per IN cord-333672-ef53l283 219 18 day day NN cord-333672-ef53l283 219 19 ) ) -RRB- cord-333672-ef53l283 219 20 may may MD cord-333672-ef53l283 219 21 enhance enhance VB cord-333672-ef53l283 219 22 sleep sleep NN cord-333672-ef53l283 219 23 quality quality NN cord-333672-ef53l283 219 24 during during IN cord-333672-ef53l283 219 25 stressful stressful JJ cord-333672-ef53l283 219 26 periods period NNS cord-333672-ef53l283 219 27 ( ( -LRB- cord-333672-ef53l283 219 28 111 111 CD cord-333672-ef53l283 219 29 , , , cord-333672-ef53l283 219 30 112 112 CD cord-333672-ef53l283 219 31 ) ) -RRB- cord-333672-ef53l283 219 32 . . . cord-333672-ef53l283 220 1 L l NN cord-333672-ef53l283 220 2 - - HYPH cord-333672-ef53l283 220 3 glycine glycine NN cord-333672-ef53l283 220 4 may may MD cord-333672-ef53l283 220 5 too too RB cord-333672-ef53l283 220 6 affect affect VB cord-333672-ef53l283 220 7 sleep sleep NN cord-333672-ef53l283 220 8 . . . cord-333672-ef53l283 221 1 Consuming consume VBG cord-333672-ef53l283 221 2 3 3 CD cord-333672-ef53l283 221 3 g g NN cord-333672-ef53l283 221 4 L l NN cord-333672-ef53l283 221 5 - - HYPH cord-333672-ef53l283 221 6 glycine glycine NN cord-333672-ef53l283 221 7 an an DT cord-333672-ef53l283 221 8 hour hour NN cord-333672-ef53l283 221 9 before before IN cord-333672-ef53l283 221 10 bedtime bedtime NN cord-333672-ef53l283 221 11 appears appear VBZ cord-333672-ef53l283 221 12 to to TO cord-333672-ef53l283 221 13 shorten shorten VB cord-333672-ef53l283 221 14 sleep sleep NN cord-333672-ef53l283 221 15 latency latency NN cord-333672-ef53l283 221 16 , , , cord-333672-ef53l283 221 17 increase increase NN cord-333672-ef53l283 221 18 sleep sleep NN cord-333672-ef53l283 221 19 efficiency efficiency NN cord-333672-ef53l283 221 20 , , , cord-333672-ef53l283 221 21 and and CC cord-333672-ef53l283 221 22 reduce reduce VB cord-333672-ef53l283 221 23 daytime daytime JJ cord-333672-ef53l283 221 24 sleepiness sleepiness NN cord-333672-ef53l283 221 25 in in IN cord-333672-ef53l283 221 26 healthy healthy JJ cord-333672-ef53l283 221 27 adults adult NNS cord-333672-ef53l283 221 28 , , , cord-333672-ef53l283 221 29 effects effect NNS cord-333672-ef53l283 221 30 that that WDT cord-333672-ef53l283 221 31 appear appear VBP cord-333672-ef53l283 221 32 to to TO cord-333672-ef53l283 221 33 be be VB cord-333672-ef53l283 221 34 mediated mediate VBN cord-333672-ef53l283 221 35 via via IN cord-333672-ef53l283 221 36 the the DT cord-333672-ef53l283 221 37 suprachiasmatic suprachiasmatic JJ cord-333672-ef53l283 221 38 nucleus nucleus NN cord-333672-ef53l283 221 39 ( ( -LRB- cord-333672-ef53l283 221 40 113 113 CD cord-333672-ef53l283 221 41 , , , cord-333672-ef53l283 221 42 114 114 CD cord-333672-ef53l283 221 43 ) ) -RRB- cord-333672-ef53l283 221 44 . . . cord-333672-ef53l283 222 1 Such such JJ cord-333672-ef53l283 222 2 supplementation supplementation NN cord-333672-ef53l283 222 3 also also RB cord-333672-ef53l283 222 4 seems seem VBZ cord-333672-ef53l283 222 5 to to TO cord-333672-ef53l283 222 6 diminish diminish VB cord-333672-ef53l283 222 7 daytime daytime JJ cord-333672-ef53l283 222 8 fatigue fatigue NN cord-333672-ef53l283 222 9 and and CC cord-333672-ef53l283 222 10 boost boost VB cord-333672-ef53l283 222 11 vigilance vigilance NN cord-333672-ef53l283 222 12 during during IN cord-333672-ef53l283 222 13 sleep sleep NN cord-333672-ef53l283 222 14 restriction restriction NN cord-333672-ef53l283 222 15 ( ( -LRB- cord-333672-ef53l283 222 16 115 115 CD cord-333672-ef53l283 222 17 ) ) -RRB- cord-333672-ef53l283 222 18 , , , cord-333672-ef53l283 222 19 implying imply VBG cord-333672-ef53l283 222 20 that that IN cord-333672-ef53l283 222 21 L l NN cord-333672-ef53l283 222 22 - - HYPH cord-333672-ef53l283 222 23 glycine glycine NN cord-333672-ef53l283 222 24 may may MD cord-333672-ef53l283 222 25 both both DT cord-333672-ef53l283 222 26 enhance enhance VB cord-333672-ef53l283 222 27 sleep sleep NN cord-333672-ef53l283 222 28 and and CC cord-333672-ef53l283 222 29 the the DT cord-333672-ef53l283 222 30 ability ability NN cord-333672-ef53l283 222 31 to to TO cord-333672-ef53l283 222 32 cope cope VB cord-333672-ef53l283 222 33 with with IN cord-333672-ef53l283 222 34 sleep sleep NN cord-333672-ef53l283 222 35 loss loss NN cord-333672-ef53l283 222 36 . . . cord-333672-ef53l283 223 1 Given give VBN cord-333672-ef53l283 223 2 that that IN cord-333672-ef53l283 223 3 L l NN cord-333672-ef53l283 223 4 - - HYPH cord-333672-ef53l283 223 5 glycine glycine NN cord-333672-ef53l283 223 6 is be VBZ cord-333672-ef53l283 223 7 safe safe JJ cord-333672-ef53l283 223 8 , , , cord-333672-ef53l283 223 9 inexpensive inexpensive JJ cord-333672-ef53l283 223 10 , , , cord-333672-ef53l283 223 11 and and CC cord-333672-ef53l283 223 12 may may MD cord-333672-ef53l283 223 13 confer confer VB cord-333672-ef53l283 223 14 other other JJ cord-333672-ef53l283 223 15 health health NN cord-333672-ef53l283 223 16 benefits benefit NNS cord-333672-ef53l283 223 17 ( ( -LRB- cord-333672-ef53l283 223 18 116 116 CD cord-333672-ef53l283 223 19 ) ) -RRB- cord-333672-ef53l283 223 20 , , , cord-333672-ef53l283 223 21 night night NN cord-333672-ef53l283 223 22 shift shift NN cord-333672-ef53l283 223 23 workers worker NNS cord-333672-ef53l283 223 24 could could MD cord-333672-ef53l283 223 25 gain gain VB cord-333672-ef53l283 223 26 from from IN cord-333672-ef53l283 223 27 supplementing supplement VBG cord-333672-ef53l283 223 28 with with IN cord-333672-ef53l283 223 29 this this DT cord-333672-ef53l283 223 30 amino amino NN cord-333672-ef53l283 223 31 acid acid NN cord-333672-ef53l283 223 32 . . . cord-333672-ef53l283 224 1 At at IN cord-333672-ef53l283 224 2 present present JJ cord-333672-ef53l283 224 3 , , , cord-333672-ef53l283 224 4 however however RB cord-333672-ef53l283 224 5 , , , cord-333672-ef53l283 224 6 there there EX cord-333672-ef53l283 224 7 has have VBZ cord-333672-ef53l283 224 8 been be VBN cord-333672-ef53l283 224 9 little little JJ cord-333672-ef53l283 224 10 research research NN cord-333672-ef53l283 224 11 on on IN cord-333672-ef53l283 224 12 effects effect NNS cord-333672-ef53l283 224 13 of of IN cord-333672-ef53l283 224 14 this this DT cord-333672-ef53l283 224 15 amino amino NN cord-333672-ef53l283 224 16 acid acid NN cord-333672-ef53l283 224 17 on on IN cord-333672-ef53l283 224 18 sleep sleep NN cord-333672-ef53l283 224 19 . . . cord-333672-ef53l283 225 1 In in IN cord-333672-ef53l283 225 2 summary summary NN cord-333672-ef53l283 225 3 , , , cord-333672-ef53l283 225 4 it -PRON- PRP cord-333672-ef53l283 225 5 is be VBZ cord-333672-ef53l283 225 6 plausible plausible JJ cord-333672-ef53l283 225 7 that that IN cord-333672-ef53l283 225 8 supplementing supplement VBG cord-333672-ef53l283 225 9 with with IN cord-333672-ef53l283 225 10 certain certain JJ cord-333672-ef53l283 225 11 amino amino NN cord-333672-ef53l283 225 12 acids acid NNS cord-333672-ef53l283 225 13 may may MD cord-333672-ef53l283 225 14 help help VB cord-333672-ef53l283 225 15 shift shift VB cord-333672-ef53l283 225 16 workers worker NNS cord-333672-ef53l283 225 17 adapt adapt VB cord-333672-ef53l283 225 18 more more RBR cord-333672-ef53l283 225 19 quickly quickly RB cord-333672-ef53l283 225 20 to to IN cord-333672-ef53l283 225 21 changes change NNS cord-333672-ef53l283 225 22 in in IN cord-333672-ef53l283 225 23 their -PRON- PRP$ cord-333672-ef53l283 225 24 shifts shift NNS cord-333672-ef53l283 225 25 and/or and/or CC cord-333672-ef53l283 225 26 sleep sleep NN cord-333672-ef53l283 225 27 better well RBR cord-333672-ef53l283 225 28 , , , cord-333672-ef53l283 225 29 but but CC cord-333672-ef53l283 225 30 this this DT cord-333672-ef53l283 225 31 is be VBZ cord-333672-ef53l283 225 32 based base VBN cord-333672-ef53l283 225 33 on on IN cord-333672-ef53l283 225 34 few few JJ cord-333672-ef53l283 225 35 studies study NNS cord-333672-ef53l283 225 36 that that WDT cord-333672-ef53l283 225 37 did do VBD cord-333672-ef53l283 225 38 not not RB cord-333672-ef53l283 225 39 control control VB cord-333672-ef53l283 225 40 zeitgeber zeitgeber NNP cord-333672-ef53l283 225 41 cycles cycle NNS cord-333672-ef53l283 225 42 or or CC cord-333672-ef53l283 225 43 explore explore VB cord-333672-ef53l283 225 44 whether whether IN cord-333672-ef53l283 225 45 the the DT cord-333672-ef53l283 225 46 circadian circadian NN cord-333672-ef53l283 225 47 timing timing NN cord-333672-ef53l283 225 48 of of IN cord-333672-ef53l283 225 49 amino amino NN cord-333672-ef53l283 225 50 acid acid NN cord-333672-ef53l283 225 51 ingestion ingestion NN cord-333672-ef53l283 225 52 interacts interact VBZ cord-333672-ef53l283 225 53 with with IN cord-333672-ef53l283 225 54 the the DT cord-333672-ef53l283 225 55 circadian circadian NN cord-333672-ef53l283 225 56 timing timing NN cord-333672-ef53l283 225 57 of of IN cord-333672-ef53l283 225 58 light light JJ cord-333672-ef53l283 225 59 exposure exposure NN cord-333672-ef53l283 225 60 . . . cord-333672-ef53l283 226 1 Going go VBG cord-333672-ef53l283 226 2 forward forward RB cord-333672-ef53l283 226 3 , , , cord-333672-ef53l283 226 4 it -PRON- PRP cord-333672-ef53l283 226 5 will will MD cord-333672-ef53l283 226 6 be be VB cord-333672-ef53l283 226 7 important important JJ cord-333672-ef53l283 226 8 to to TO cord-333672-ef53l283 226 9 address address VB cord-333672-ef53l283 226 10 these these DT cord-333672-ef53l283 226 11 limitations limitation NNS cord-333672-ef53l283 226 12 . . . cord-333672-ef53l283 227 1 It -PRON- PRP cord-333672-ef53l283 227 2 will will MD cord-333672-ef53l283 227 3 also also RB cord-333672-ef53l283 227 4 be be VB cord-333672-ef53l283 227 5 interesting interesting JJ cord-333672-ef53l283 227 6 to to TO cord-333672-ef53l283 227 7 see see VB cord-333672-ef53l283 227 8 whether whether IN cord-333672-ef53l283 227 9 concurrent concurrent JJ cord-333672-ef53l283 227 10 consumption consumption NN cord-333672-ef53l283 227 11 of of IN cord-333672-ef53l283 227 12 different different JJ cord-333672-ef53l283 227 13 chronobiotic chronobiotic JJ cord-333672-ef53l283 227 14 agents agent NNS cord-333672-ef53l283 227 15 additively additively RB cord-333672-ef53l283 227 16 boosts boost VBZ cord-333672-ef53l283 227 17 circadian circadian NN cord-333672-ef53l283 227 18 phase phase NN cord-333672-ef53l283 227 19 shifts shift NNS cord-333672-ef53l283 227 20 . . . cord-333672-ef53l283 228 1 We -PRON- PRP cord-333672-ef53l283 228 2 have have VBP cord-333672-ef53l283 228 3 mentioned mention VBN cord-333672-ef53l283 228 4 several several JJ cord-333672-ef53l283 228 5 ideas idea NNS cord-333672-ef53l283 228 6 for for IN cord-333672-ef53l283 228 7 future future JJ cord-333672-ef53l283 228 8 studies study NNS cord-333672-ef53l283 228 9 , , , cord-333672-ef53l283 228 10 and and CC cord-333672-ef53l283 228 11 we -PRON- PRP cord-333672-ef53l283 228 12 will will MD cord-333672-ef53l283 228 13 end end VB cord-333672-ef53l283 228 14 by by IN cord-333672-ef53l283 228 15 focusing focus VBG cord-333672-ef53l283 228 16 on on IN cord-333672-ef53l283 228 17 additional additional JJ cord-333672-ef53l283 228 18 research research NN cord-333672-ef53l283 228 19 avenues avenue NNS cord-333672-ef53l283 228 20 that that WDT cord-333672-ef53l283 228 21 may may MD cord-333672-ef53l283 228 22 be be VB cord-333672-ef53l283 228 23 worth worth JJ cord-333672-ef53l283 228 24 exploring explore VBG cord-333672-ef53l283 228 25 with with IN cord-333672-ef53l283 228 26 respect respect NN cord-333672-ef53l283 228 27 to to IN cord-333672-ef53l283 228 28 improving improve VBG cord-333672-ef53l283 228 29 the the DT cord-333672-ef53l283 228 30 health health NN cord-333672-ef53l283 228 31 of of IN cord-333672-ef53l283 228 32 shift shift NN cord-333672-ef53l283 228 33 workers worker NNS cord-333672-ef53l283 228 34 . . . cord-333672-ef53l283 229 1 Rapid rapid JJ cord-333672-ef53l283 229 2 recent recent JJ cord-333672-ef53l283 229 3 advances advance NNS cord-333672-ef53l283 229 4 in in IN cord-333672-ef53l283 229 5 the the DT cord-333672-ef53l283 229 6 development development NN cord-333672-ef53l283 229 7 and and CC cord-333672-ef53l283 229 8 uptake uptake NN cord-333672-ef53l283 229 9 of of IN cord-333672-ef53l283 229 10 digital digital JJ cord-333672-ef53l283 229 11 technologies technology NNS cord-333672-ef53l283 229 12 such such JJ cord-333672-ef53l283 229 13 as as IN cord-333672-ef53l283 229 14 smartphones smartphone NNS cord-333672-ef53l283 229 15 , , , cord-333672-ef53l283 229 16 apps app NNS cord-333672-ef53l283 229 17 , , , cord-333672-ef53l283 229 18 wearables wearable NNS cord-333672-ef53l283 229 19 , , , cord-333672-ef53l283 229 20 and and CC cord-333672-ef53l283 229 21 artificial artificial JJ cord-333672-ef53l283 229 22 intelligence intelligence NN cord-333672-ef53l283 229 23 provide provide VBP cord-333672-ef53l283 229 24 scientists scientist NNS cord-333672-ef53l283 229 25 with with IN cord-333672-ef53l283 229 26 an an DT cord-333672-ef53l283 229 27 unprecedented unprecedented JJ cord-333672-ef53l283 229 28 ability ability NN cord-333672-ef53l283 229 29 to to TO cord-333672-ef53l283 229 30 comprehensively comprehensively RB cord-333672-ef53l283 229 31 assess assess VB cord-333672-ef53l283 229 32 people people NNS cord-333672-ef53l283 229 33 's 's POS cord-333672-ef53l283 229 34 behaviours behaviour NNS cord-333672-ef53l283 229 35 and and CC cord-333672-ef53l283 229 36 health health NN cord-333672-ef53l283 229 37 in in IN cord-333672-ef53l283 229 38 freeliving freelive VBG cord-333672-ef53l283 229 39 contexts context NNS cord-333672-ef53l283 229 40 . . . cord-333672-ef53l283 230 1 The the DT cord-333672-ef53l283 230 2 myCircadianClock mycircadianclock DT cord-333672-ef53l283 230 3 app app NN cord-333672-ef53l283 230 4 is be VBZ cord-333672-ef53l283 230 5 a a DT cord-333672-ef53l283 230 6 salient salient JJ cord-333672-ef53l283 230 7 example example NN cord-333672-ef53l283 230 8 of of IN cord-333672-ef53l283 230 9 such such JJ cord-333672-ef53l283 230 10 technology technology NN cord-333672-ef53l283 230 11 . . . cord-333672-ef53l283 231 1 This this DT cord-333672-ef53l283 231 2 app app NN cord-333672-ef53l283 231 3 has have VBZ cord-333672-ef53l283 231 4 already already RB cord-333672-ef53l283 231 5 been be VBN cord-333672-ef53l283 231 6 used use VBN cord-333672-ef53l283 231 7 in in IN cord-333672-ef53l283 231 8 multiple multiple JJ cord-333672-ef53l283 231 9 studies study NNS cord-333672-ef53l283 231 10 to to TO cord-333672-ef53l283 231 11 monitor monitor VB cord-333672-ef53l283 231 12 the the DT cord-333672-ef53l283 231 13 circadian circadian NN cord-333672-ef53l283 231 14 phenotypes phenotype NNS cord-333672-ef53l283 231 15 of of IN cord-333672-ef53l283 231 16 study study NN cord-333672-ef53l283 231 17 participants participant NNS cord-333672-ef53l283 231 18 , , , cord-333672-ef53l283 231 19 unveiling unveil VBG cord-333672-ef53l283 231 20 interesting interesting JJ cord-333672-ef53l283 231 21 insights insight NNS cord-333672-ef53l283 231 22 into into IN cord-333672-ef53l283 231 23 the the DT cord-333672-ef53l283 231 24 effects effect NNS cord-333672-ef53l283 231 25 of of IN cord-333672-ef53l283 231 26 interventions intervention NNS cord-333672-ef53l283 231 27 such such JJ cord-333672-ef53l283 231 28 as as IN cord-333672-ef53l283 231 29 TRE TRE NNP cord-333672-ef53l283 231 30 on on IN cord-333672-ef53l283 231 31 human human JJ cord-333672-ef53l283 231 32 health health NN cord-333672-ef53l283 231 33 ( ( -LRB- cord-333672-ef53l283 231 34 64 64 CD cord-333672-ef53l283 231 35 , , , cord-333672-ef53l283 231 36 117 117 CD cord-333672-ef53l283 231 37 ) ) -RRB- cord-333672-ef53l283 231 38 . . . cord-333672-ef53l283 232 1 As as IN cord-333672-ef53l283 232 2 data datum NNS cord-333672-ef53l283 232 3 collected collect VBN cord-333672-ef53l283 232 4 from from IN cord-333672-ef53l283 232 5 digital digital JJ cord-333672-ef53l283 232 6 devices device NNS cord-333672-ef53l283 232 7 are be VBP cord-333672-ef53l283 232 8 time time NN cord-333672-ef53l283 232 9 - - HYPH cord-333672-ef53l283 232 10 stamped stamp VBN cord-333672-ef53l283 232 11 , , , cord-333672-ef53l283 232 12 it -PRON- PRP cord-333672-ef53l283 232 13 is be VBZ cord-333672-ef53l283 232 14 easier easy JJR cord-333672-ef53l283 232 15 than than IN cord-333672-ef53l283 232 16 ever ever RB cord-333672-ef53l283 232 17 to to TO cord-333672-ef53l283 232 18 temporally temporally RB cord-333672-ef53l283 232 19 map map VB cord-333672-ef53l283 232 20 behavioural behavioural JJ cord-333672-ef53l283 232 21 patterns pattern NNS cord-333672-ef53l283 232 22 and and CC cord-333672-ef53l283 232 23 their -PRON- PRP$ cord-333672-ef53l283 232 24 biological biological JJ cord-333672-ef53l283 232 25 sequelae sequela NNS cord-333672-ef53l283 232 26 , , , cord-333672-ef53l283 232 27 which which WDT cord-333672-ef53l283 232 28 could could MD cord-333672-ef53l283 232 29 provide provide VB cord-333672-ef53l283 232 30 novel novel JJ cord-333672-ef53l283 232 31 insights insight NNS cord-333672-ef53l283 232 32 into into IN cord-333672-ef53l283 232 33 the the DT cord-333672-ef53l283 232 34 causes cause NNS cord-333672-ef53l283 232 35 of of IN cord-333672-ef53l283 232 36 changes change NNS cord-333672-ef53l283 232 37 in in IN cord-333672-ef53l283 232 38 the the DT cord-333672-ef53l283 232 39 health health NN cord-333672-ef53l283 232 40 trajectories trajectory NNS cord-333672-ef53l283 232 41 of of IN cord-333672-ef53l283 232 42 shift shift NN cord-333672-ef53l283 232 43 workers worker NNS cord-333672-ef53l283 232 44 . . . cord-333672-ef53l283 233 1 One one PRP cord-333672-ef53l283 233 2 could could MD cord-333672-ef53l283 233 3 identify identify VB cord-333672-ef53l283 233 4 the the DT cord-333672-ef53l283 233 5 hours hour NNS cord-333672-ef53l283 233 6 of of IN cord-333672-ef53l283 233 7 the the DT cord-333672-ef53l283 233 8 day day NN cord-333672-ef53l283 233 9 in in IN cord-333672-ef53l283 233 10 which which WDT cord-333672-ef53l283 233 11 it -PRON- PRP cord-333672-ef53l283 233 12 is be VBZ cord-333672-ef53l283 233 13 most most RBS cord-333672-ef53l283 233 14 frequently frequently RB cord-333672-ef53l283 233 15 a a DT cord-333672-ef53l283 233 16 shift shift NN cord-333672-ef53l283 233 17 worker worker NN cord-333672-ef53l283 233 18 's 's POS cord-333672-ef53l283 233 19 biological biological JJ cord-333672-ef53l283 233 20 daytime daytime NN cord-333672-ef53l283 233 21 by by IN cord-333672-ef53l283 233 22 longitudinally longitudinally RB cord-333672-ef53l283 233 23 assessing assess VBG cord-333672-ef53l283 233 24 the the DT cord-333672-ef53l283 233 25 timing timing NN cord-333672-ef53l283 233 26 of of IN cord-333672-ef53l283 233 27 the the DT cord-333672-ef53l283 233 28 individual individual NN cord-333672-ef53l283 233 29 's 's POS cord-333672-ef53l283 233 30 biological biological JJ cord-333672-ef53l283 233 31 clock clock NN cord-333672-ef53l283 233 32 . . . cord-333672-ef53l283 234 1 As as IN cord-333672-ef53l283 234 2 it -PRON- PRP cord-333672-ef53l283 234 3 is be VBZ cord-333672-ef53l283 234 4 not not RB cord-333672-ef53l283 234 5 currently currently RB cord-333672-ef53l283 234 6 practical practical JJ cord-333672-ef53l283 234 7 to to TO cord-333672-ef53l283 234 8 assess assess VB cord-333672-ef53l283 234 9 an an DT cord-333672-ef53l283 234 10 individual individual NN cord-333672-ef53l283 234 11 's 's POS cord-333672-ef53l283 234 12 melatonin melatonin NN cord-333672-ef53l283 234 13 rhythm rhythm NN cord-333672-ef53l283 234 14 on on IN cord-333672-ef53l283 234 15 a a DT cord-333672-ef53l283 234 16 daily daily JJ cord-333672-ef53l283 234 17 basis basis NN cord-333672-ef53l283 234 18 , , , cord-333672-ef53l283 234 19 the the DT cord-333672-ef53l283 234 20 integration integration NN cord-333672-ef53l283 234 21 of of IN cord-333672-ef53l283 234 22 data datum NNS cord-333672-ef53l283 234 23 from from IN cord-333672-ef53l283 234 24 surrogate surrogate JJ cord-333672-ef53l283 234 25 markers marker NNS cord-333672-ef53l283 234 26 of of IN cord-333672-ef53l283 234 27 circadian circadian NN cord-333672-ef53l283 234 28 phase phase NN cord-333672-ef53l283 234 29 such such JJ cord-333672-ef53l283 234 30 as as IN cord-333672-ef53l283 234 31 body body NN cord-333672-ef53l283 234 32 temperature temperature NN cord-333672-ef53l283 234 33 and and CC cord-333672-ef53l283 234 34 sleep sleep NN cord-333672-ef53l283 234 35 / / SYM cord-333672-ef53l283 234 36 wake wake VBP cord-333672-ef53l283 234 37 cycles cycle NNS cord-333672-ef53l283 234 38 could could MD cord-333672-ef53l283 234 39 be be VB cord-333672-ef53l283 234 40 used use VBN cord-333672-ef53l283 234 41 to to TO cord-333672-ef53l283 234 42 approximate approximate VB cord-333672-ef53l283 234 43 the the DT cord-333672-ef53l283 234 44 timing timing NN cord-333672-ef53l283 234 45 of of IN cord-333672-ef53l283 234 46 the the DT cord-333672-ef53l283 234 47 biological biological JJ cord-333672-ef53l283 234 48 daytime daytime NN cord-333672-ef53l283 234 49 . . . cord-333672-ef53l283 235 1 These these DT cord-333672-ef53l283 235 2 cycles cycle NNS cord-333672-ef53l283 235 3 could could MD cord-333672-ef53l283 235 4 be be VB cord-333672-ef53l283 235 5 monitored monitor VBN cord-333672-ef53l283 235 6 ambiently ambiently RB cord-333672-ef53l283 235 7 using use VBG cord-333672-ef53l283 235 8 data datum NNS cord-333672-ef53l283 235 9 from from IN cord-333672-ef53l283 235 10 devices device NNS cord-333672-ef53l283 235 11 such such JJ cord-333672-ef53l283 235 12 as as IN cord-333672-ef53l283 235 13 smartphones smartphone NNS cord-333672-ef53l283 235 14 , , , cord-333672-ef53l283 235 15 and and CC cord-333672-ef53l283 235 16 the the DT cord-333672-ef53l283 235 17 data datum NNS cord-333672-ef53l283 235 18 from from IN cord-333672-ef53l283 235 19 the the DT cord-333672-ef53l283 235 20 devices device NNS cord-333672-ef53l283 235 21 could could MD cord-333672-ef53l283 235 22 then then RB cord-333672-ef53l283 235 23 be be VB cord-333672-ef53l283 235 24 used use VBN cord-333672-ef53l283 235 25 to to TO cord-333672-ef53l283 235 26 inform inform VB cord-333672-ef53l283 235 27 individual individual JJ cord-333672-ef53l283 235 28 shift shift VB cord-333672-ef53l283 235 29 workers worker NNS cord-333672-ef53l283 235 30 about about IN cord-333672-ef53l283 235 31 how how WRB cord-333672-ef53l283 235 32 to to TO cord-333672-ef53l283 235 33 best best RB cord-333672-ef53l283 235 34 implement implement VB cord-333672-ef53l283 235 35 TRE TRE NNP cord-333672-ef53l283 235 36 . . . cord-333672-ef53l283 236 1 Where where WRB cord-333672-ef53l283 236 2 feasible feasible JJ cord-333672-ef53l283 236 3 , , , cord-333672-ef53l283 236 4 this this DT cord-333672-ef53l283 236 5 process process NN cord-333672-ef53l283 236 6 could could MD cord-333672-ef53l283 236 7 be be VB cord-333672-ef53l283 236 8 refined refine VBN cord-333672-ef53l283 236 9 FIGURE figure NN cord-333672-ef53l283 236 10 1 1 CD cord-333672-ef53l283 236 11 | | NNS cord-333672-ef53l283 237 1 Using use VBG cord-333672-ef53l283 237 2 digital digital JJ cord-333672-ef53l283 237 3 devices device NNS cord-333672-ef53l283 237 4 to to TO cord-333672-ef53l283 237 5 optimise optimise VB cord-333672-ef53l283 237 6 the the DT cord-333672-ef53l283 237 7 health health NN cord-333672-ef53l283 237 8 and and CC cord-333672-ef53l283 237 9 performance performance NN cord-333672-ef53l283 237 10 of of IN cord-333672-ef53l283 237 11 shift shift NN cord-333672-ef53l283 237 12 workers worker NNS cord-333672-ef53l283 237 13 by by IN cord-333672-ef53l283 237 14 providing provide VBG cord-333672-ef53l283 237 15 personalised personalised JJ cord-333672-ef53l283 237 16 guidance guidance NN cord-333672-ef53l283 237 17 , , , cord-333672-ef53l283 237 18 work work NN cord-333672-ef53l283 237 19 schedules schedule NNS cord-333672-ef53l283 237 20 , , , cord-333672-ef53l283 237 21 and and CC cord-333672-ef53l283 237 22 zeitgeber zeitgeber NNP cord-333672-ef53l283 237 23 schedules schedule NNS cord-333672-ef53l283 237 24 . . . cord-333672-ef53l283 238 1 ( ( -LRB- cord-333672-ef53l283 238 2 1 1 LS cord-333672-ef53l283 238 3 ) ) -RRB- cord-333672-ef53l283 238 4 Digital digital JJ cord-333672-ef53l283 238 5 devices device NNS cord-333672-ef53l283 238 6 can can MD cord-333672-ef53l283 238 7 be be VB cord-333672-ef53l283 238 8 used use VBN cord-333672-ef53l283 238 9 to to TO cord-333672-ef53l283 238 10 monitor monitor VB cord-333672-ef53l283 238 11 behaviours behaviour NNS cord-333672-ef53l283 238 12 and and CC cord-333672-ef53l283 238 13 their -PRON- PRP$ cord-333672-ef53l283 238 14 biological biological JJ cord-333672-ef53l283 238 15 responses response NNS cord-333672-ef53l283 238 16 , , , cord-333672-ef53l283 238 17 including include VBG cord-333672-ef53l283 238 18 ( ( -LRB- cord-333672-ef53l283 238 19 i i NN cord-333672-ef53l283 238 20 ) ) -RRB- cord-333672-ef53l283 238 21 exposures exposure NNS cord-333672-ef53l283 238 22 to to IN cord-333672-ef53l283 238 23 variables variable NNS cord-333672-ef53l283 238 24 such such JJ cord-333672-ef53l283 238 25 as as IN cord-333672-ef53l283 238 26 light light NN cord-333672-ef53l283 238 27 ( ( -LRB- cord-333672-ef53l283 238 28 e.g. e.g. RB cord-333672-ef53l283 238 29 , , , cord-333672-ef53l283 238 30 via via IN cord-333672-ef53l283 238 31 head head NN cord-333672-ef53l283 238 32 - - HYPH cord-333672-ef53l283 238 33 worn wear VBN cord-333672-ef53l283 238 34 wearables wearable NNS cord-333672-ef53l283 238 35 ) ) -RRB- cord-333672-ef53l283 238 36 , , , cord-333672-ef53l283 238 37 ( ( -LRB- cord-333672-ef53l283 238 38 ii ii NN cord-333672-ef53l283 238 39 ) ) -RRB- cord-333672-ef53l283 238 40 dietary dietary JJ cord-333672-ef53l283 238 41 behaviours behaviour NNS cord-333672-ef53l283 238 42 ( ( -LRB- cord-333672-ef53l283 238 43 e.g. e.g. RB cord-333672-ef53l283 238 44 , , , cord-333672-ef53l283 238 45 via via IN cord-333672-ef53l283 238 46 food food NN cord-333672-ef53l283 238 47 photography photography NN cord-333672-ef53l283 238 48 and and CC cord-333672-ef53l283 238 49 continuous continuous JJ cord-333672-ef53l283 238 50 glucose glucose NN cord-333672-ef53l283 238 51 monitoring monitoring NN cord-333672-ef53l283 238 52 ) ) -RRB- cord-333672-ef53l283 238 53 , , , cord-333672-ef53l283 238 54 and and CC cord-333672-ef53l283 238 55 ( ( -LRB- cord-333672-ef53l283 238 56 iii iii NN cord-333672-ef53l283 238 57 ) ) -RRB- cord-333672-ef53l283 238 58 physical physical JJ cord-333672-ef53l283 238 59 activity activity NN cord-333672-ef53l283 238 60 ( ( -LRB- cord-333672-ef53l283 238 61 e.g. e.g. RB cord-333672-ef53l283 238 62 , , , cord-333672-ef53l283 238 63 via via IN cord-333672-ef53l283 238 64 smart smart JJ cord-333672-ef53l283 238 65 watches watch NNS cord-333672-ef53l283 238 66 ) ) -RRB- cord-333672-ef53l283 238 67 . . . cord-333672-ef53l283 239 1 Digital digital JJ cord-333672-ef53l283 239 2 phenotyping phenotyping NN cord-333672-ef53l283 239 3 using use VBG cord-333672-ef53l283 239 4 patterns pattern NNS cord-333672-ef53l283 239 5 of of IN cord-333672-ef53l283 239 6 smartphone smartphone NN cord-333672-ef53l283 239 7 use use NN cord-333672-ef53l283 239 8 can can MD cord-333672-ef53l283 239 9 be be VB cord-333672-ef53l283 239 10 used use VBN cord-333672-ef53l283 239 11 to to TO cord-333672-ef53l283 239 12 enrich enrich VB cord-333672-ef53l283 239 13 this this DT cord-333672-ef53l283 239 14 analysis analysis NN cord-333672-ef53l283 239 15 . . . cord-333672-ef53l283 240 1 ( ( -LRB- cord-333672-ef53l283 240 2 2 2 LS cord-333672-ef53l283 240 3 ) ) -RRB- cord-333672-ef53l283 241 1 These these DT cord-333672-ef53l283 241 2 data datum NNS cord-333672-ef53l283 241 3 and and CC cord-333672-ef53l283 241 4 their -PRON- PRP$ cord-333672-ef53l283 241 5 interactions interaction NNS cord-333672-ef53l283 241 6 can can MD cord-333672-ef53l283 241 7 then then RB cord-333672-ef53l283 241 8 be be VB cord-333672-ef53l283 241 9 analysed analyse VBN cord-333672-ef53l283 241 10 in in IN cord-333672-ef53l283 241 11 real real JJ cord-333672-ef53l283 241 12 time time NN cord-333672-ef53l283 241 13 and and CC cord-333672-ef53l283 241 14 used use VBD cord-333672-ef53l283 241 15 to to IN cord-333672-ef53l283 241 16 ( ( -LRB- cord-333672-ef53l283 241 17 3 3 LS cord-333672-ef53l283 241 18 ) ) -RRB- cord-333672-ef53l283 241 19 personalise personalise VB cord-333672-ef53l283 241 20 guidance guidance NN cord-333672-ef53l283 241 21 , , , cord-333672-ef53l283 241 22 shift shift NN cord-333672-ef53l283 241 23 schedules schedule NNS cord-333672-ef53l283 241 24 , , , cord-333672-ef53l283 241 25 and and CC cord-333672-ef53l283 241 26 zeitgeber zeitgeber NNP cord-333672-ef53l283 241 27 schedules schedule NNS cord-333672-ef53l283 241 28 of of IN cord-333672-ef53l283 241 29 individual individual JJ cord-333672-ef53l283 241 30 workers worker NNS cord-333672-ef53l283 241 31 . . . cord-333672-ef53l283 242 1 Guidance guidance NN cord-333672-ef53l283 242 2 can can MD cord-333672-ef53l283 242 3 be be VB cord-333672-ef53l283 242 4 delivered deliver VBN cord-333672-ef53l283 242 5 digitally digitally RB cord-333672-ef53l283 242 6 and and CC cord-333672-ef53l283 242 7 in in IN cord-333672-ef53l283 242 8 - - HYPH cord-333672-ef53l283 242 9 person person NN cord-333672-ef53l283 242 10 , , , cord-333672-ef53l283 242 11 and and CC cord-333672-ef53l283 242 12 innovative innovative JJ cord-333672-ef53l283 242 13 technologies technology NNS cord-333672-ef53l283 242 14 may may MD cord-333672-ef53l283 242 15 eventually eventually RB cord-333672-ef53l283 242 16 allow allow VB cord-333672-ef53l283 242 17 the the DT cord-333672-ef53l283 242 18 automation automation NN cord-333672-ef53l283 242 19 of of IN cord-333672-ef53l283 242 20 adjustments adjustment NNS cord-333672-ef53l283 242 21 to to IN cord-333672-ef53l283 242 22 individual individual JJ cord-333672-ef53l283 242 23 workers worker NNS cord-333672-ef53l283 242 24 ' ' POS cord-333672-ef53l283 242 25 zeitgeber zeitgeber NNP cord-333672-ef53l283 242 26 schedules schedule NNS cord-333672-ef53l283 242 27 . . . cord-333672-ef53l283 243 1 with with IN cord-333672-ef53l283 243 2 the the DT cord-333672-ef53l283 243 3 addition addition NN cord-333672-ef53l283 243 4 of of IN cord-333672-ef53l283 243 5 round round JJ cord-333672-ef53l283 243 6 - - HYPH cord-333672-ef53l283 243 7 the the DT cord-333672-ef53l283 243 8 - - HYPH cord-333672-ef53l283 243 9 clock clock NN cord-333672-ef53l283 243 10 measures measure NNS cord-333672-ef53l283 243 11 of of IN cord-333672-ef53l283 243 12 metabolic metabolic JJ cord-333672-ef53l283 243 13 regulation regulation NN cord-333672-ef53l283 243 14 , , , cord-333672-ef53l283 243 15 such such JJ cord-333672-ef53l283 243 16 as as IN cord-333672-ef53l283 243 17 continuous continuous JJ cord-333672-ef53l283 243 18 glucose glucose NN cord-333672-ef53l283 243 19 monitoring monitoring NN cord-333672-ef53l283 243 20 . . . cord-333672-ef53l283 244 1 At at IN cord-333672-ef53l283 244 2 a a DT cord-333672-ef53l283 244 3 small small JJ cord-333672-ef53l283 244 4 scale scale NN cord-333672-ef53l283 244 5 , , , cord-333672-ef53l283 244 6 the the DT cord-333672-ef53l283 244 7 feasibility feasibility NN cord-333672-ef53l283 244 8 of of IN cord-333672-ef53l283 244 9 this this DT cord-333672-ef53l283 244 10 type type NN cord-333672-ef53l283 244 11 of of IN cord-333672-ef53l283 244 12 approach approach NN cord-333672-ef53l283 244 13 has have VBZ cord-333672-ef53l283 244 14 already already RB cord-333672-ef53l283 244 15 been be VBN cord-333672-ef53l283 244 16 shown show VBN cord-333672-ef53l283 244 17 ( ( -LRB- cord-333672-ef53l283 244 18 118 118 CD cord-333672-ef53l283 244 19 ) ) -RRB- cord-333672-ef53l283 244 20 . . . cord-333672-ef53l283 245 1 Ultimately ultimately RB cord-333672-ef53l283 245 2 , , , cord-333672-ef53l283 245 3 implementing implement VBG cord-333672-ef53l283 245 4 such such JJ cord-333672-ef53l283 245 5 methods method NNS cord-333672-ef53l283 245 6 at at IN cord-333672-ef53l283 245 7 a a DT cord-333672-ef53l283 245 8 large large JJ cord-333672-ef53l283 245 9 scale scale NN cord-333672-ef53l283 245 10 and and CC cord-333672-ef53l283 245 11 including include VBG cord-333672-ef53l283 245 12 both both DT cord-333672-ef53l283 245 13 shift shift JJ cord-333672-ef53l283 245 14 workers worker NNS cord-333672-ef53l283 245 15 and and CC cord-333672-ef53l283 245 16 non non JJ cord-333672-ef53l283 245 17 - - JJ cord-333672-ef53l283 245 18 shift shift JJ cord-333672-ef53l283 245 19 - - HYPH cord-333672-ef53l283 245 20 working working JJ cord-333672-ef53l283 245 21 controls control NNS cord-333672-ef53l283 245 22 may may MD cord-333672-ef53l283 245 23 help help VB cord-333672-ef53l283 245 24 develop develop VB cord-333672-ef53l283 245 25 models model NNS cord-333672-ef53l283 245 26 that that WDT cord-333672-ef53l283 245 27 forecast forecast VBP cord-333672-ef53l283 245 28 transitions transition NNS cord-333672-ef53l283 245 29 in in IN cord-333672-ef53l283 245 30 the the DT cord-333672-ef53l283 245 31 health health NN cord-333672-ef53l283 245 32 of of IN cord-333672-ef53l283 245 33 shift shift NN cord-333672-ef53l283 245 34 workers worker NNS cord-333672-ef53l283 245 35 , , , cord-333672-ef53l283 245 36 as as RB cord-333672-ef53l283 245 37 well well RB cord-333672-ef53l283 245 38 as as IN cord-333672-ef53l283 245 39 how how WRB cord-333672-ef53l283 245 40 to to TO cord-333672-ef53l283 245 41 alter alter VB cord-333672-ef53l283 245 42 these these DT cord-333672-ef53l283 245 43 trajectories trajectory NNS cord-333672-ef53l283 245 44 . . . cord-333672-ef53l283 246 1 However however RB cord-333672-ef53l283 246 2 , , , cord-333672-ef53l283 246 3 the the DT cord-333672-ef53l283 246 4 data data NN cord-333672-ef53l283 246 5 collection collection NN cord-333672-ef53l283 246 6 process process NN cord-333672-ef53l283 246 7 will will MD cord-333672-ef53l283 246 8 need need VB cord-333672-ef53l283 246 9 to to TO cord-333672-ef53l283 246 10 be be VB cord-333672-ef53l283 246 11 relatively relatively RB cord-333672-ef53l283 246 12 frictionless frictionless JJ cord-333672-ef53l283 246 13 ( ( -LRB- cord-333672-ef53l283 246 14 for for IN cord-333672-ef53l283 246 15 participants participant NNS cord-333672-ef53l283 246 16 , , , cord-333672-ef53l283 246 17 at at IN cord-333672-ef53l283 246 18 least least JJS cord-333672-ef53l283 246 19 ) ) -RRB- cord-333672-ef53l283 246 20 to to TO cord-333672-ef53l283 246 21 achieve achieve VB cord-333672-ef53l283 246 22 this this DT cord-333672-ef53l283 246 23 . . . cord-333672-ef53l283 247 1 This this DT cord-333672-ef53l283 247 2 will will MD cord-333672-ef53l283 247 3 be be VB cord-333672-ef53l283 247 4 facilitated facilitate VBN cord-333672-ef53l283 247 5 by by IN cord-333672-ef53l283 247 6 close close JJ cord-333672-ef53l283 247 7 collaboration collaboration NN cord-333672-ef53l283 247 8 between between IN cord-333672-ef53l283 247 9 scientists scientist NNS cord-333672-ef53l283 247 10 and and CC cord-333672-ef53l283 247 11 workers worker NNS cord-333672-ef53l283 247 12 in in IN cord-333672-ef53l283 247 13 the the DT cord-333672-ef53l283 247 14 technology technology NN cord-333672-ef53l283 247 15 sector sector NN cord-333672-ef53l283 247 16 . . . cord-333672-ef53l283 248 1 With with IN cord-333672-ef53l283 248 2 accurate accurate JJ cord-333672-ef53l283 248 3 monitoring monitoring NN cord-333672-ef53l283 248 4 in in IN cord-333672-ef53l283 248 5 place place NN cord-333672-ef53l283 248 6 , , , cord-333672-ef53l283 248 7 digital digital JJ cord-333672-ef53l283 248 8 tools tool NNS cord-333672-ef53l283 248 9 could could MD cord-333672-ef53l283 248 10 then then RB cord-333672-ef53l283 248 11 be be VB cord-333672-ef53l283 248 12 implemented implement VBN cord-333672-ef53l283 248 13 to to TO cord-333672-ef53l283 248 14 improve improve VB cord-333672-ef53l283 248 15 the the DT cord-333672-ef53l283 248 16 health health NN cord-333672-ef53l283 248 17 and and CC cord-333672-ef53l283 248 18 productivity productivity NN cord-333672-ef53l283 248 19 of of IN cord-333672-ef53l283 248 20 shift shift NN cord-333672-ef53l283 248 21 workers worker NNS cord-333672-ef53l283 248 22 by by IN cord-333672-ef53l283 248 23 optimising optimise VBG cord-333672-ef53l283 248 24 variables variable NNS cord-333672-ef53l283 248 25 such such JJ cord-333672-ef53l283 248 26 as as IN cord-333672-ef53l283 248 27 zeitgeber zeitgeber NNP cord-333672-ef53l283 248 28 schedules schedule NNS cord-333672-ef53l283 248 29 in in IN cord-333672-ef53l283 248 30 real real JJ cord-333672-ef53l283 248 31 time time NN cord-333672-ef53l283 249 1 ( ( -LRB- cord-333672-ef53l283 249 2 Figure figure NN cord-333672-ef53l283 249 3 1 1 CD cord-333672-ef53l283 249 4 ) ) -RRB- cord-333672-ef53l283 249 5 . . . cord-333672-ef53l283 250 1 Innovative innovative JJ cord-333672-ef53l283 250 2 technologies technology NNS cord-333672-ef53l283 250 3 could could MD cord-333672-ef53l283 250 4 also also RB cord-333672-ef53l283 250 5 provide provide VB cord-333672-ef53l283 250 6 novel novel JJ cord-333672-ef53l283 250 7 means mean NNS cord-333672-ef53l283 250 8 of of IN cord-333672-ef53l283 250 9 generating generate VBG cord-333672-ef53l283 250 10 insightful insightful JJ cord-333672-ef53l283 250 11 data datum NNS cord-333672-ef53l283 250 12 while while IN cord-333672-ef53l283 250 13 minimising minimise VBG cord-333672-ef53l283 250 14 participant participant NN cord-333672-ef53l283 250 15 burden burden NN cord-333672-ef53l283 250 16 . . . cord-333672-ef53l283 251 1 For for IN cord-333672-ef53l283 251 2 example example NN cord-333672-ef53l283 251 3 , , , cord-333672-ef53l283 251 4 sensors sensor NNS cord-333672-ef53l283 251 5 commonly commonly RB cord-333672-ef53l283 251 6 built build VBN cord-333672-ef53l283 251 7 into into IN cord-333672-ef53l283 251 8 smartphones smartphone NNS cord-333672-ef53l283 251 9 can can MD cord-333672-ef53l283 251 10 now now RB cord-333672-ef53l283 251 11 be be VB cord-333672-ef53l283 251 12 used use VBN cord-333672-ef53l283 251 13 to to TO cord-333672-ef53l283 251 14 monitor monitor VB cord-333672-ef53l283 251 15 blood blood NN cord-333672-ef53l283 251 16 parameters parameter NNS cord-333672-ef53l283 251 17 such such JJ cord-333672-ef53l283 251 18 as as IN cord-333672-ef53l283 251 19 haemoglobin haemoglobin NN cord-333672-ef53l283 251 20 that that WDT cord-333672-ef53l283 251 21 once once RB cord-333672-ef53l283 251 22 required require VBD cord-333672-ef53l283 251 23 invasive invasive JJ cord-333672-ef53l283 251 24 testing testing NN cord-333672-ef53l283 251 25 ( ( -LRB- cord-333672-ef53l283 251 26 119 119 CD cord-333672-ef53l283 251 27 ) ) -RRB- cord-333672-ef53l283 251 28 . . . cord-333672-ef53l283 252 1 Smartphones smartphone NNS cord-333672-ef53l283 252 2 can can MD cord-333672-ef53l283 252 3 also also RB cord-333672-ef53l283 252 4 be be VB cord-333672-ef53l283 252 5 used use VBN cord-333672-ef53l283 252 6 to to TO cord-333672-ef53l283 252 7 monitor monitor VB cord-333672-ef53l283 252 8 some some DT cord-333672-ef53l283 252 9 exposures exposure NNS cord-333672-ef53l283 252 10 that that WDT cord-333672-ef53l283 252 11 are be VBP cord-333672-ef53l283 252 12 particularly particularly RB cord-333672-ef53l283 252 13 relevant relevant JJ cord-333672-ef53l283 252 14 to to TO cord-333672-ef53l283 252 15 shift shift VB cord-333672-ef53l283 252 16 workers worker NNS cord-333672-ef53l283 252 17 , , , cord-333672-ef53l283 252 18 such such JJ cord-333672-ef53l283 252 19 as as IN cord-333672-ef53l283 252 20 patterns pattern NNS cord-333672-ef53l283 252 21 of of IN cord-333672-ef53l283 252 22 locomotion locomotion NN cord-333672-ef53l283 252 23 and and CC cord-333672-ef53l283 252 24 exposure exposure NN cord-333672-ef53l283 252 25 to to IN cord-333672-ef53l283 252 26 light light NN cord-333672-ef53l283 252 27 . . . cord-333672-ef53l283 253 1 One one CD cord-333672-ef53l283 253 2 problem problem NN cord-333672-ef53l283 253 3 , , , cord-333672-ef53l283 253 4 however however RB cord-333672-ef53l283 253 5 , , , cord-333672-ef53l283 253 6 is be VBZ cord-333672-ef53l283 253 7 that that IN cord-333672-ef53l283 253 8 it -PRON- PRP cord-333672-ef53l283 253 9 would would MD cord-333672-ef53l283 253 10 be be VB cord-333672-ef53l283 253 11 especially especially RB cord-333672-ef53l283 253 12 useful useful JJ cord-333672-ef53l283 253 13 to to TO cord-333672-ef53l283 253 14 assess assess VB cord-333672-ef53l283 253 15 exposure exposure NN cord-333672-ef53l283 253 16 to to IN cord-333672-ef53l283 253 17 light light NN cord-333672-ef53l283 253 18 at at IN cord-333672-ef53l283 253 19 the the DT cord-333672-ef53l283 253 20 level level NN cord-333672-ef53l283 253 21 of of IN cord-333672-ef53l283 253 22 the the DT cord-333672-ef53l283 253 23 eye eye NN cord-333672-ef53l283 253 24 . . . cord-333672-ef53l283 254 1 This this DT cord-333672-ef53l283 254 2 requires require VBZ cord-333672-ef53l283 254 3 new new JJ cord-333672-ef53l283 254 4 wearable wearable JJ cord-333672-ef53l283 254 5 devices device NNS cord-333672-ef53l283 254 6 , , , cord-333672-ef53l283 254 7 for for IN cord-333672-ef53l283 254 8 smartphones smartphone NNS cord-333672-ef53l283 254 9 are be VBP cord-333672-ef53l283 254 10 not not RB cord-333672-ef53l283 254 11 suited suited JJ cord-333672-ef53l283 254 12 to to IN cord-333672-ef53l283 254 13 this this DT cord-333672-ef53l283 254 14 , , , cord-333672-ef53l283 254 15 and and CC cord-333672-ef53l283 254 16 many many JJ cord-333672-ef53l283 254 17 existing exist VBG cord-333672-ef53l283 254 18 wearables wearable NNS cord-333672-ef53l283 254 19 that that WDT cord-333672-ef53l283 254 20 measure measure VBP cord-333672-ef53l283 254 21 light light JJ cord-333672-ef53l283 254 22 exposure exposure NN cord-333672-ef53l283 254 23 are be VBP cord-333672-ef53l283 254 24 frequently frequently RB cord-333672-ef53l283 254 25 obstructed obstruct VBN cord-333672-ef53l283 254 26 by by IN cord-333672-ef53l283 254 27 clothing clothing NN cord-333672-ef53l283 254 28 , , , cord-333672-ef53l283 254 29 confounding confound VBG cord-333672-ef53l283 254 30 their -PRON- PRP$ cord-333672-ef53l283 254 31 data datum NNS cord-333672-ef53l283 254 32 . . . cord-333672-ef53l283 255 1 It -PRON- PRP cord-333672-ef53l283 255 2 is be VBZ cord-333672-ef53l283 255 3 possible possible JJ cord-333672-ef53l283 255 4 to to TO cord-333672-ef53l283 255 5 make make VB cord-333672-ef53l283 255 6 smart smart JJ cord-333672-ef53l283 255 7 eyewear eyewear NN cord-333672-ef53l283 255 8 to to TO cord-333672-ef53l283 255 9 estimate estimate VB cord-333672-ef53l283 255 10 retinal retinal JJ cord-333672-ef53l283 255 11 light light JJ cord-333672-ef53l283 255 12 exposure exposure NN cord-333672-ef53l283 255 13 , , , cord-333672-ef53l283 255 14 and and CC cord-333672-ef53l283 255 15 such such JJ cord-333672-ef53l283 255 16 eyewear eyewear NN cord-333672-ef53l283 255 17 may may MD cord-333672-ef53l283 255 18 be be VB cord-333672-ef53l283 255 19 especially especially RB cord-333672-ef53l283 255 20 useful useful JJ cord-333672-ef53l283 255 21 for for IN cord-333672-ef53l283 255 22 another another DT cord-333672-ef53l283 255 23 purpose purpose NN cord-333672-ef53l283 255 24 . . . cord-333672-ef53l283 256 1 The the DT cord-333672-ef53l283 256 2 utility utility NN cord-333672-ef53l283 256 3 of of IN cord-333672-ef53l283 256 4 all all DT cord-333672-ef53l283 256 5 of of IN cord-333672-ef53l283 256 6 these these DT cord-333672-ef53l283 256 7 monitoring monitoring NN cord-333672-ef53l283 256 8 technologies technology NNS cord-333672-ef53l283 256 9 may may MD cord-333672-ef53l283 256 10 be be VB cord-333672-ef53l283 256 11 enhanced enhance VBN cord-333672-ef53l283 256 12 by by IN cord-333672-ef53l283 256 13 the the DT cord-333672-ef53l283 256 14 addition addition NN cord-333672-ef53l283 256 15 of of IN cord-333672-ef53l283 256 16 the the DT cord-333672-ef53l283 256 17 ability ability NN cord-333672-ef53l283 256 18 to to TO cord-333672-ef53l283 256 19 digitally digitally RB cord-333672-ef53l283 256 20 " " `` cord-333672-ef53l283 256 21 envirotype envirotype FW cord-333672-ef53l283 256 22 " " '' cord-333672-ef53l283 256 23 individuals individual NNS cord-333672-ef53l283 256 24 , , , cord-333672-ef53l283 256 25 ambiently ambiently RB cord-333672-ef53l283 256 26 tracking track VBG cord-333672-ef53l283 256 27 information information NN cord-333672-ef53l283 256 28 about about IN cord-333672-ef53l283 256 29 their -PRON- PRP$ cord-333672-ef53l283 256 30 environments environment NNS cord-333672-ef53l283 256 31 to to TO cord-333672-ef53l283 256 32 better better RB cord-333672-ef53l283 256 33 understand understand VB cord-333672-ef53l283 256 34 the the DT cord-333672-ef53l283 256 35 interaction interaction NN cord-333672-ef53l283 256 36 between between IN cord-333672-ef53l283 256 37 environment environment NN cord-333672-ef53l283 256 38 and and CC cord-333672-ef53l283 256 39 phenotype phenotype NN cord-333672-ef53l283 256 40 ( ( -LRB- cord-333672-ef53l283 256 41 120 120 CD cord-333672-ef53l283 256 42 ) ) -RRB- cord-333672-ef53l283 256 43 . . . cord-333672-ef53l283 257 1 Building build VBG cord-333672-ef53l283 257 2 camera camera NN cord-333672-ef53l283 257 3 technology technology NN cord-333672-ef53l283 257 4 into into IN cord-333672-ef53l283 257 5 eyewear eyewear NN cord-333672-ef53l283 257 6 is be VBZ cord-333672-ef53l283 257 7 one one CD cord-333672-ef53l283 257 8 way way NN cord-333672-ef53l283 257 9 to to TO cord-333672-ef53l283 257 10 accomplish accomplish VB cord-333672-ef53l283 257 11 this this DT cord-333672-ef53l283 257 12 . . . cord-333672-ef53l283 258 1 Meanwhile meanwhile RB cord-333672-ef53l283 258 2 , , , cord-333672-ef53l283 258 3 digital digital JJ cord-333672-ef53l283 258 4 phenotyping phenotyping NN cord-333672-ef53l283 258 5 -assessing -assesse VBG cord-333672-ef53l283 258 6 changes change NNS cord-333672-ef53l283 258 7 in in IN cord-333672-ef53l283 258 8 people people NNS cord-333672-ef53l283 258 9 's 's POS cord-333672-ef53l283 258 10 phenotypes phenotype NNS cord-333672-ef53l283 258 11 using use VBG cord-333672-ef53l283 258 12 data datum NNS cord-333672-ef53l283 258 13 from from IN cord-333672-ef53l283 258 14 digital digital JJ cord-333672-ef53l283 258 15 devices device NNS cord-333672-ef53l283 258 16 -has -has : cord-333672-ef53l283 258 17 already already RB cord-333672-ef53l283 258 18 been be VBN cord-333672-ef53l283 258 19 used use VBN cord-333672-ef53l283 258 20 to to TO cord-333672-ef53l283 258 21 identify identify VB cord-333672-ef53l283 258 22 patients patient NNS cord-333672-ef53l283 258 23 ' ' POS cord-333672-ef53l283 258 24 disease disease NN cord-333672-ef53l283 258 25 trajectories trajectory NNS cord-333672-ef53l283 258 26 in in IN cord-333672-ef53l283 258 27 neurological neurological JJ cord-333672-ef53l283 258 28 disorders disorder NNS cord-333672-ef53l283 258 29 such such JJ cord-333672-ef53l283 258 30 as as IN cord-333672-ef53l283 258 31 schizophrenia schizophrenia NNP cord-333672-ef53l283 258 32 ( ( -LRB- cord-333672-ef53l283 258 33 121 121 CD cord-333672-ef53l283 258 34 ) ) -RRB- cord-333672-ef53l283 258 35 . . . cord-333672-ef53l283 259 1 Such such JJ cord-333672-ef53l283 259 2 phenotyping phenotyping NN cord-333672-ef53l283 259 3 can can MD cord-333672-ef53l283 259 4 proceed proceed VB cord-333672-ef53l283 259 5 without without IN cord-333672-ef53l283 259 6 active active JJ cord-333672-ef53l283 259 7 user user NN cord-333672-ef53l283 259 8 engagement engagement NN cord-333672-ef53l283 259 9 , , , cord-333672-ef53l283 259 10 and and CC cord-333672-ef53l283 259 11 it -PRON- PRP cord-333672-ef53l283 259 12 can can MD cord-333672-ef53l283 259 13 also also RB cord-333672-ef53l283 259 14 be be VB cord-333672-ef53l283 259 15 used use VBN cord-333672-ef53l283 259 16 to to TO cord-333672-ef53l283 259 17 assess assess VB cord-333672-ef53l283 259 18 behaviours behaviour NNS cord-333672-ef53l283 259 19 such such JJ cord-333672-ef53l283 259 20 as as IN cord-333672-ef53l283 259 21 sleep sleep NN cord-333672-ef53l283 259 22 ( ( -LRB- cord-333672-ef53l283 259 23 122 122 CD cord-333672-ef53l283 259 24 ) ) -RRB- cord-333672-ef53l283 259 25 . . . cord-333672-ef53l283 260 1 Ultimately ultimately RB cord-333672-ef53l283 260 2 , , , cord-333672-ef53l283 260 3 use use NN cord-333672-ef53l283 260 4 of of IN cord-333672-ef53l283 260 5 multimodal multimodal JJ cord-333672-ef53l283 260 6 novel novel JJ cord-333672-ef53l283 260 7 sensors sensor NNS cord-333672-ef53l283 260 8 that that WDT cord-333672-ef53l283 260 9 analyse analyse VBP cord-333672-ef53l283 260 10 biofluids biofluid NNS cord-333672-ef53l283 260 11 including include VBG cord-333672-ef53l283 260 12 interstitial interstitial JJ cord-333672-ef53l283 260 13 fluid fluid NN cord-333672-ef53l283 260 14 ( ( -LRB- cord-333672-ef53l283 260 15 e.g. e.g. RB cord-333672-ef53l283 260 16 , , , cord-333672-ef53l283 260 17 continuous continuous JJ cord-333672-ef53l283 260 18 glucose glucose NN cord-333672-ef53l283 260 19 monitoring monitoring NN cord-333672-ef53l283 260 20 ) ) -RRB- cord-333672-ef53l283 260 21 , , , cord-333672-ef53l283 260 22 saliva saliva NN cord-333672-ef53l283 260 23 , , , cord-333672-ef53l283 260 24 sweat sweat NN cord-333672-ef53l283 260 25 , , , cord-333672-ef53l283 260 26 and and CC cord-333672-ef53l283 260 27 tears tear NNS cord-333672-ef53l283 260 28 may may MD cord-333672-ef53l283 260 29 prove prove VB cord-333672-ef53l283 260 30 particularly particularly RB cord-333672-ef53l283 260 31 useful useful JJ cord-333672-ef53l283 260 32 in in IN cord-333672-ef53l283 260 33 monitoring monitor VBG cord-333672-ef53l283 260 34 variables variable NNS cord-333672-ef53l283 260 35 such such JJ cord-333672-ef53l283 260 36 as as IN cord-333672-ef53l283 260 37 dietary dietary JJ cord-333672-ef53l283 260 38 intakes intake NNS cord-333672-ef53l283 260 39 and and CC cord-333672-ef53l283 260 40 associated associate VBD cord-333672-ef53l283 260 41 changes change NNS cord-333672-ef53l283 260 42 in in IN cord-333672-ef53l283 260 43 metabolites metabolite NNS cord-333672-ef53l283 260 44 ( ( -LRB- cord-333672-ef53l283 260 45 123 123 CD cord-333672-ef53l283 260 46 ) ) -RRB- cord-333672-ef53l283 260 47 . . . cord-333672-ef53l283 261 1 However however RB cord-333672-ef53l283 261 2 , , , cord-333672-ef53l283 261 3 the the DT cord-333672-ef53l283 261 4 development development NN cord-333672-ef53l283 261 5 of of IN cord-333672-ef53l283 261 6 these these DT cord-333672-ef53l283 261 7 sensors sensor NNS cord-333672-ef53l283 261 8 poses pose VBZ cord-333672-ef53l283 261 9 substantial substantial JJ cord-333672-ef53l283 261 10 challenges challenge NNS cord-333672-ef53l283 261 11 related relate VBN cord-333672-ef53l283 261 12 to to IN cord-333672-ef53l283 261 13 biofouling biofouling NN cord-333672-ef53l283 261 14 , , , cord-333672-ef53l283 261 15 accuracy accuracy NN cord-333672-ef53l283 261 16 , , , cord-333672-ef53l283 261 17 power power NN cord-333672-ef53l283 261 18 , , , cord-333672-ef53l283 261 19 usability usability NN cord-333672-ef53l283 261 20 , , , cord-333672-ef53l283 261 21 calibration calibration NN cord-333672-ef53l283 261 22 , , , cord-333672-ef53l283 261 23 and and CC cord-333672-ef53l283 261 24 data datum NNS cord-333672-ef53l283 261 25 security security NN cord-333672-ef53l283 261 26 . . . cord-333672-ef53l283 262 1 These these DT cord-333672-ef53l283 262 2 tools tool NNS cord-333672-ef53l283 262 3 are be VBP cord-333672-ef53l283 262 4 promising promising JJ cord-333672-ef53l283 262 5 approaches approach NNS cord-333672-ef53l283 262 6 to to IN cord-333672-ef53l283 262 7 forecasting forecasting NN cord-333672-ef53l283 262 8 changes change NNS cord-333672-ef53l283 262 9 in in IN cord-333672-ef53l283 262 10 behaviours behaviour NNS cord-333672-ef53l283 262 11 and and CC cord-333672-ef53l283 262 12 health health NN cord-333672-ef53l283 262 13 , , , cord-333672-ef53l283 262 14 and and CC cord-333672-ef53l283 262 15 we -PRON- PRP cord-333672-ef53l283 262 16 hope hope VBP cord-333672-ef53l283 262 17 they -PRON- PRP cord-333672-ef53l283 262 18 will will MD cord-333672-ef53l283 262 19 help help VB cord-333672-ef53l283 262 20 healthcare healthcare NN cord-333672-ef53l283 262 21 professionals professional NNS cord-333672-ef53l283 262 22 intervene intervene VB cord-333672-ef53l283 262 23 before before IN cord-333672-ef53l283 262 24 individuals individual NNS cord-333672-ef53l283 262 25 succumb succumb VBP cord-333672-ef53l283 262 26 to to IN cord-333672-ef53l283 262 27 disease disease NN cord-333672-ef53l283 262 28 . . . cord-333672-ef53l283 263 1 We -PRON- PRP cord-333672-ef53l283 263 2 foresee foresee VBP cord-333672-ef53l283 263 3 that that IN cord-333672-ef53l283 263 4 using use VBG cord-333672-ef53l283 263 5 sophisticated sophisticated JJ cord-333672-ef53l283 263 6 computational computational JJ cord-333672-ef53l283 263 7 methods method NNS cord-333672-ef53l283 263 8 such such JJ cord-333672-ef53l283 263 9 as as IN cord-333672-ef53l283 263 10 deep deep JJ cord-333672-ef53l283 263 11 learning learning NN cord-333672-ef53l283 263 12 to to TO cord-333672-ef53l283 263 13 concurrently concurrently RB cord-333672-ef53l283 263 14 analyse analyse VB cord-333672-ef53l283 263 15 individuals individual NNS cord-333672-ef53l283 263 16 ' ' POS cord-333672-ef53l283 263 17 behavioural behavioural JJ cord-333672-ef53l283 263 18 , , , cord-333672-ef53l283 263 19 health health NN cord-333672-ef53l283 263 20 , , , cord-333672-ef53l283 263 21 and and CC cord-333672-ef53l283 263 22 environmental environmental JJ cord-333672-ef53l283 263 23 data datum NNS cord-333672-ef53l283 263 24 from from IN cord-333672-ef53l283 263 25 multimodal multimodal NN cord-333672-ef53l283 263 26 sources source NNS cord-333672-ef53l283 263 27 will will MD cord-333672-ef53l283 263 28 eventually eventually RB cord-333672-ef53l283 263 29 enhance enhance VB cord-333672-ef53l283 263 30 personalisation personalisation NN cord-333672-ef53l283 263 31 of of IN cord-333672-ef53l283 263 32 guidance guidance NN cord-333672-ef53l283 263 33 for for IN cord-333672-ef53l283 263 34 individual individual JJ cord-333672-ef53l283 263 35 shift shift NN cord-333672-ef53l283 263 36 workers worker NNS cord-333672-ef53l283 263 37 ( ( -LRB- cord-333672-ef53l283 263 38 124 124 CD cord-333672-ef53l283 263 39 ) ) -RRB- cord-333672-ef53l283 263 40 . . . cord-333672-ef53l283 264 1 Even even RB cord-333672-ef53l283 264 2 if if IN cord-333672-ef53l283 264 3 shift shift NN cord-333672-ef53l283 264 4 workers worker NNS cord-333672-ef53l283 264 5 understand understand VBP cord-333672-ef53l283 264 6 precisely precisely RB cord-333672-ef53l283 264 7 which which WDT cord-333672-ef53l283 264 8 behaviours behaviour NNS cord-333672-ef53l283 264 9 they -PRON- PRP cord-333672-ef53l283 264 10 should should MD cord-333672-ef53l283 264 11 enact enact VB cord-333672-ef53l283 264 12 to to TO cord-333672-ef53l283 264 13 improve improve VB cord-333672-ef53l283 264 14 their -PRON- PRP$ cord-333672-ef53l283 264 15 health health NN cord-333672-ef53l283 264 16 , , , cord-333672-ef53l283 264 17 they -PRON- PRP cord-333672-ef53l283 264 18 are be VBP cord-333672-ef53l283 264 19 prone prone JJ cord-333672-ef53l283 264 20 to to IN cord-333672-ef53l283 264 21 a a DT cord-333672-ef53l283 264 22 variety variety NN cord-333672-ef53l283 264 23 of of IN cord-333672-ef53l283 264 24 factors factor NNS cord-333672-ef53l283 264 25 that that WDT cord-333672-ef53l283 264 26 impair impair VBP cord-333672-ef53l283 264 27 decision decision NN cord-333672-ef53l283 264 28 making making NN cord-333672-ef53l283 264 29 , , , cord-333672-ef53l283 264 30 such such JJ cord-333672-ef53l283 264 31 as as IN cord-333672-ef53l283 264 32 circadian circadian NN cord-333672-ef53l283 264 33 system system NN cord-333672-ef53l283 264 34 misalignment misalignment NN cord-333672-ef53l283 264 35 and and CC cord-333672-ef53l283 264 36 sleep sleep NN cord-333672-ef53l283 264 37 loss loss NN cord-333672-ef53l283 264 38 ( ( -LRB- cord-333672-ef53l283 264 39 125 125 CD cord-333672-ef53l283 264 40 , , , cord-333672-ef53l283 264 41 126 126 CD cord-333672-ef53l283 264 42 ) ) -RRB- cord-333672-ef53l283 264 43 . . . cord-333672-ef53l283 265 1 Furthermore furthermore RB cord-333672-ef53l283 265 2 , , , cord-333672-ef53l283 265 3 knowledge knowledge NN cord-333672-ef53l283 265 4 alone alone RB cord-333672-ef53l283 265 5 is be VBZ cord-333672-ef53l283 265 6 rarely rarely RB cord-333672-ef53l283 265 7 sufficient sufficient JJ cord-333672-ef53l283 265 8 to to TO cord-333672-ef53l283 265 9 support support VB cord-333672-ef53l283 265 10 lasting last VBG cord-333672-ef53l283 265 11 health health NN cord-333672-ef53l283 265 12 behaviour behaviour NN cord-333672-ef53l283 265 13 change change NN cord-333672-ef53l283 265 14 ( ( -LRB- cord-333672-ef53l283 265 15 127 127 CD cord-333672-ef53l283 265 16 ) ) -RRB- cord-333672-ef53l283 265 17 . . . cord-333672-ef53l283 266 1 It -PRON- PRP cord-333672-ef53l283 266 2 is be VBZ cord-333672-ef53l283 266 3 therefore therefore RB cord-333672-ef53l283 266 4 imperative imperative JJ cord-333672-ef53l283 266 5 to to TO cord-333672-ef53l283 266 6 support support VB cord-333672-ef53l283 266 7 the the DT cord-333672-ef53l283 266 8 ability ability NN cord-333672-ef53l283 266 9 of of IN cord-333672-ef53l283 266 10 these these DT cord-333672-ef53l283 266 11 people people NNS cord-333672-ef53l283 266 12 to to TO cord-333672-ef53l283 266 13 make make VB cord-333672-ef53l283 266 14 smart smart JJ cord-333672-ef53l283 266 15 decisions decision NNS cord-333672-ef53l283 266 16 , , , cord-333672-ef53l283 266 17 and and CC cord-333672-ef53l283 266 18 this this DT cord-333672-ef53l283 266 19 requires require VBZ cord-333672-ef53l283 266 20 applying apply VBG cord-333672-ef53l283 266 21 principles principle NNS cord-333672-ef53l283 266 22 from from IN cord-333672-ef53l283 266 23 behavioural behavioural JJ cord-333672-ef53l283 266 24 science science NN cord-333672-ef53l283 266 25 , , , cord-333672-ef53l283 266 26 particularly particularly RB cord-333672-ef53l283 266 27 at at IN cord-333672-ef53l283 266 28 the the DT cord-333672-ef53l283 266 29 level level NN cord-333672-ef53l283 266 30 of of IN cord-333672-ef53l283 266 31 the the DT cord-333672-ef53l283 266 32 organisations organisation NNS cord-333672-ef53l283 266 33 that that WDT cord-333672-ef53l283 266 34 employ employ VBP cord-333672-ef53l283 266 35 shift shift NN cord-333672-ef53l283 266 36 workers worker NNS cord-333672-ef53l283 266 37 . . . cord-333672-ef53l283 267 1 Significantly significantly RB cord-333672-ef53l283 267 2 , , , cord-333672-ef53l283 267 3 many many JJ cord-333672-ef53l283 267 4 new new JJ cord-333672-ef53l283 267 5 technologies technology NNS cord-333672-ef53l283 267 6 are be VBP cord-333672-ef53l283 267 7 strikingly strikingly RB cord-333672-ef53l283 267 8 habitforming habitforme VBG cord-333672-ef53l283 267 9 , , , cord-333672-ef53l283 267 10 and and CC cord-333672-ef53l283 267 11 this this DT cord-333672-ef53l283 267 12 exemplifies exemplify VBZ cord-333672-ef53l283 267 13 the the DT cord-333672-ef53l283 267 14 power power NN cord-333672-ef53l283 267 15 of of IN cord-333672-ef53l283 267 16 applying apply VBG cord-333672-ef53l283 267 17 behavioural behavioural JJ cord-333672-ef53l283 267 18 science science NN cord-333672-ef53l283 267 19 principles principle NNS cord-333672-ef53l283 267 20 to to TO cord-333672-ef53l283 267 21 shape shape VB cord-333672-ef53l283 267 22 behaviour behaviour NN cord-333672-ef53l283 267 23 . . . cord-333672-ef53l283 268 1 If if IN cord-333672-ef53l283 268 2 scientists scientist NNS cord-333672-ef53l283 268 3 and and CC cord-333672-ef53l283 268 4 technologists technologist NNS cord-333672-ef53l283 268 5 can can MD cord-333672-ef53l283 268 6 collaborate collaborate VB cord-333672-ef53l283 268 7 to to TO cord-333672-ef53l283 268 8 effectively effectively RB cord-333672-ef53l283 268 9 use use VB cord-333672-ef53l283 268 10 behavioural behavioural JJ cord-333672-ef53l283 268 11 science science NN cord-333672-ef53l283 268 12 to to TO cord-333672-ef53l283 268 13 create create VB cord-333672-ef53l283 268 14 engaging engaging JJ cord-333672-ef53l283 268 15 , , , cord-333672-ef53l283 268 16 scalable scalable JJ cord-333672-ef53l283 268 17 products product NNS cord-333672-ef53l283 268 18 that that WDT cord-333672-ef53l283 268 19 deliver deliver VBP cord-333672-ef53l283 268 20 tailored tailor VBN cord-333672-ef53l283 268 21 health health NN cord-333672-ef53l283 268 22 guidance guidance NN cord-333672-ef53l283 268 23 to to TO cord-333672-ef53l283 268 24 shift shift VB cord-333672-ef53l283 268 25 workers worker NNS cord-333672-ef53l283 268 26 , , , cord-333672-ef53l283 268 27 all all DT cord-333672-ef53l283 268 28 would would MD cord-333672-ef53l283 268 29 benefit benefit VB cord-333672-ef53l283 268 30 . . . cord-333672-ef53l283 269 1 We -PRON- PRP cord-333672-ef53l283 269 2 believe believe VBP cord-333672-ef53l283 269 3 that that IN cord-333672-ef53l283 269 4 technologies technology NNS cord-333672-ef53l283 269 5 that that WDT cord-333672-ef53l283 269 6 deliver deliver VBP cord-333672-ef53l283 269 7 adaptive adaptive JJ cord-333672-ef53l283 269 8 interventions intervention NNS cord-333672-ef53l283 269 9 to to IN cord-333672-ef53l283 269 10 both both DT cord-333672-ef53l283 269 11 help help VB cord-333672-ef53l283 269 12 people people NNS cord-333672-ef53l283 269 13 avoid avoid VB cord-333672-ef53l283 269 14 poor poor JJ cord-333672-ef53l283 269 15 health health NN cord-333672-ef53l283 269 16 decisions decision NNS cord-333672-ef53l283 269 17 during during IN cord-333672-ef53l283 269 18 states state NNS cord-333672-ef53l283 269 19 of of IN cord-333672-ef53l283 269 20 vulnerability vulnerability NN cord-333672-ef53l283 269 21 and and CC cord-333672-ef53l283 269 22 support support VB cord-333672-ef53l283 269 23 good good JJ cord-333672-ef53l283 269 24 health health NN cord-333672-ef53l283 269 25 decisions decision NNS cord-333672-ef53l283 269 26 during during IN cord-333672-ef53l283 269 27 states state NNS cord-333672-ef53l283 269 28 of of IN cord-333672-ef53l283 269 29 opportunity opportunity NN cord-333672-ef53l283 269 30 will will MD cord-333672-ef53l283 269 31 be be VB cord-333672-ef53l283 269 32 particularly particularly RB cord-333672-ef53l283 269 33 advantageous advantageous JJ cord-333672-ef53l283 269 34 ( ( -LRB- cord-333672-ef53l283 269 35 128 128 CD cord-333672-ef53l283 269 36 ) ) -RRB- cord-333672-ef53l283 269 37 . . . cord-333672-ef53l283 270 1 The the DT cord-333672-ef53l283 270 2 built build VBN cord-333672-ef53l283 270 3 environment environment NN cord-333672-ef53l283 270 4 also also RB cord-333672-ef53l283 270 5 affects affect VBZ cord-333672-ef53l283 270 6 health health NN cord-333672-ef53l283 270 7 in in IN cord-333672-ef53l283 270 8 numerous numerous JJ cord-333672-ef53l283 270 9 ways way NNS cord-333672-ef53l283 270 10 ( ( -LRB- cord-333672-ef53l283 270 11 129 129 CD cord-333672-ef53l283 270 12 ) ) -RRB- cord-333672-ef53l283 270 13 , , , cord-333672-ef53l283 270 14 and and CC cord-333672-ef53l283 270 15 given give VBN cord-333672-ef53l283 270 16 that that DT cord-333672-ef53l283 270 17 shift shift NN cord-333672-ef53l283 270 18 workers worker NNS cord-333672-ef53l283 270 19 are be VBP cord-333672-ef53l283 270 20 prone prone JJ cord-333672-ef53l283 270 21 to to IN cord-333672-ef53l283 270 22 health health NN cord-333672-ef53l283 270 23 problems problem NNS cord-333672-ef53l283 270 24 , , , cord-333672-ef53l283 270 25 it -PRON- PRP cord-333672-ef53l283 270 26 is be VBZ cord-333672-ef53l283 270 27 particularly particularly RB cord-333672-ef53l283 270 28 critical critical JJ cord-333672-ef53l283 270 29 to to TO cord-333672-ef53l283 270 30 pay pay VB cord-333672-ef53l283 270 31 attention attention NN cord-333672-ef53l283 270 32 to to IN cord-333672-ef53l283 270 33 optimising optimise VBG cord-333672-ef53l283 270 34 the the DT cord-333672-ef53l283 270 35 workplaces workplace NNS cord-333672-ef53l283 270 36 of of IN cord-333672-ef53l283 270 37 these these DT cord-333672-ef53l283 270 38 people people NNS cord-333672-ef53l283 270 39 . . . cord-333672-ef53l283 271 1 As as IN cord-333672-ef53l283 271 2 shift shift NN cord-333672-ef53l283 271 3 workers worker NNS cord-333672-ef53l283 271 4 commonly commonly RB cord-333672-ef53l283 271 5 experience experience VBP cord-333672-ef53l283 271 6 circadian circadian NN cord-333672-ef53l283 271 7 system system NN cord-333672-ef53l283 271 8 disruption disruption NN cord-333672-ef53l283 271 9 and and CC cord-333672-ef53l283 271 10 do do VBP cord-333672-ef53l283 271 11 not not RB cord-333672-ef53l283 271 12 gain gain VB cord-333672-ef53l283 271 13 tolerance tolerance NN cord-333672-ef53l283 271 14 to to IN cord-333672-ef53l283 271 15 such such JJ cord-333672-ef53l283 271 16 disruption disruption NN cord-333672-ef53l283 271 17 ( ( -LRB- cord-333672-ef53l283 271 18 130 130 CD cord-333672-ef53l283 271 19 ) ) -RRB- cord-333672-ef53l283 271 20 , , , cord-333672-ef53l283 271 21 it -PRON- PRP cord-333672-ef53l283 271 22 may may MD cord-333672-ef53l283 271 23 be be VB cord-333672-ef53l283 271 24 valuable valuable JJ cord-333672-ef53l283 271 25 to to TO cord-333672-ef53l283 271 26 create create VB cord-333672-ef53l283 271 27 workplaces workplace NNS cord-333672-ef53l283 271 28 that that WDT cord-333672-ef53l283 271 29 allow allow VBP cord-333672-ef53l283 271 30 close close JJ cord-333672-ef53l283 271 31 control control NN cord-333672-ef53l283 271 32 over over IN cord-333672-ef53l283 271 33 exposure exposure NN cord-333672-ef53l283 271 34 to to IN cord-333672-ef53l283 271 35 light light NN cord-333672-ef53l283 271 36 , , , cord-333672-ef53l283 271 37 and and CC cord-333672-ef53l283 271 38 intelligent intelligent JJ cord-333672-ef53l283 271 39 use use NN cord-333672-ef53l283 271 40 of of IN cord-333672-ef53l283 271 41 " " `` cord-333672-ef53l283 271 42 smart smart JJ cord-333672-ef53l283 271 43 " " '' cord-333672-ef53l283 271 44 lighting lighting NN cord-333672-ef53l283 271 45 systems system NNS cord-333672-ef53l283 271 46 may may MD cord-333672-ef53l283 271 47 benefit benefit VB cord-333672-ef53l283 271 48 these these DT cord-333672-ef53l283 271 49 individuals individual NNS cord-333672-ef53l283 271 50 . . . cord-333672-ef53l283 272 1 We -PRON- PRP cord-333672-ef53l283 272 2 also also RB cord-333672-ef53l283 272 3 anticipate anticipate VBP cord-333672-ef53l283 272 4 the the DT cord-333672-ef53l283 272 5 development development NN cord-333672-ef53l283 272 6 of of IN cord-333672-ef53l283 272 7 closed closed JJ cord-333672-ef53l283 272 8 - - HYPH cord-333672-ef53l283 272 9 loop loop NN cord-333672-ef53l283 272 10 devices device NNS cord-333672-ef53l283 272 11 that that WDT cord-333672-ef53l283 272 12 will will MD cord-333672-ef53l283 272 13 personalise personalise VB cord-333672-ef53l283 272 14 light light JJ cord-333672-ef53l283 272 15 exposure exposure NN cord-333672-ef53l283 272 16 at at IN cord-333672-ef53l283 272 17 the the DT cord-333672-ef53l283 272 18 level level NN cord-333672-ef53l283 272 19 of of IN cord-333672-ef53l283 272 20 the the DT cord-333672-ef53l283 272 21 individual individual NN cord-333672-ef53l283 272 22 . . . cord-333672-ef53l283 273 1 The the DT cord-333672-ef53l283 273 2 built build VBN cord-333672-ef53l283 273 3 environment environment NN cord-333672-ef53l283 273 4 influences influence VBZ cord-333672-ef53l283 273 5 physical physical JJ cord-333672-ef53l283 273 6 activity activity NN cord-333672-ef53l283 273 7 . . . cord-333672-ef53l283 274 1 To to TO cord-333672-ef53l283 274 2 support support VB cord-333672-ef53l283 274 3 job job NN cord-333672-ef53l283 274 4 performance performance NN cord-333672-ef53l283 274 5 and and CC cord-333672-ef53l283 274 6 health health NN cord-333672-ef53l283 274 7 , , , cord-333672-ef53l283 274 8 workplaces workplace NNS cord-333672-ef53l283 274 9 should should MD cord-333672-ef53l283 274 10 have have VB cord-333672-ef53l283 274 11 designated designate VBN cord-333672-ef53l283 274 12 exercise exercise NN cord-333672-ef53l283 274 13 spaces space NNS cord-333672-ef53l283 274 14 to to TO cord-333672-ef53l283 274 15 encourage encourage VB cord-333672-ef53l283 274 16 physical physical JJ cord-333672-ef53l283 274 17 activity activity NN cord-333672-ef53l283 274 18 . . . cord-333672-ef53l283 275 1 Environmental environmental JJ cord-333672-ef53l283 275 2 design design NN cord-333672-ef53l283 275 3 is be VBZ cord-333672-ef53l283 275 4 relevant relevant JJ cord-333672-ef53l283 275 5 to to IN cord-333672-ef53l283 275 6 nutrition nutrition NN cord-333672-ef53l283 275 7 too too RB cord-333672-ef53l283 275 8 . . . cord-333672-ef53l283 276 1 Dietary dietary JJ cord-333672-ef53l283 276 2 choices choice NNS cord-333672-ef53l283 276 3 depend depend VBP cord-333672-ef53l283 276 4 strongly strongly RB cord-333672-ef53l283 276 5 on on RB cord-333672-ef53l283 276 6 where where WRB cord-333672-ef53l283 276 7 foods food NNS cord-333672-ef53l283 276 8 and and CC cord-333672-ef53l283 276 9 drinks drink NNS cord-333672-ef53l283 276 10 are be VBP cord-333672-ef53l283 276 11 sourced source VBN cord-333672-ef53l283 276 12 from from IN cord-333672-ef53l283 276 13 . . . cord-333672-ef53l283 277 1 In in IN cord-333672-ef53l283 277 2 work work NN cord-333672-ef53l283 277 3 settings setting NNS cord-333672-ef53l283 277 4 such such JJ cord-333672-ef53l283 277 5 as as IN cord-333672-ef53l283 277 6 airplanes airplane NNS cord-333672-ef53l283 277 7 , , , cord-333672-ef53l283 277 8 food food NN cord-333672-ef53l283 277 9 is be VBZ cord-333672-ef53l283 277 10 provided provide VBN cord-333672-ef53l283 277 11 for for IN cord-333672-ef53l283 277 12 shift shift NN cord-333672-ef53l283 277 13 workers worker NNS cord-333672-ef53l283 277 14 . . . cord-333672-ef53l283 278 1 However however RB cord-333672-ef53l283 278 2 , , , cord-333672-ef53l283 278 3 most most JJS cord-333672-ef53l283 278 4 shift shift JJ cord-333672-ef53l283 278 5 workers worker NNS cord-333672-ef53l283 278 6 are be VBP cord-333672-ef53l283 278 7 left leave VBN cord-333672-ef53l283 278 8 to to TO cord-333672-ef53l283 278 9 source source VB cord-333672-ef53l283 278 10 their -PRON- PRP$ cord-333672-ef53l283 278 11 own own JJ cord-333672-ef53l283 278 12 food food NN cord-333672-ef53l283 278 13 , , , cord-333672-ef53l283 278 14 and and CC cord-333672-ef53l283 278 15 when when WRB cord-333672-ef53l283 278 16 short short JJ cord-333672-ef53l283 278 17 on on IN cord-333672-ef53l283 278 18 time time NN cord-333672-ef53l283 278 19 many many JJ cord-333672-ef53l283 278 20 shift shift NN cord-333672-ef53l283 278 21 workers worker NNS cord-333672-ef53l283 278 22 buy buy VBP cord-333672-ef53l283 278 23 foods food NNS cord-333672-ef53l283 278 24 and and CC cord-333672-ef53l283 278 25 drinks drink NNS cord-333672-ef53l283 278 26 from from IN cord-333672-ef53l283 278 27 vending vend VBG cord-333672-ef53l283 278 28 machines machine NNS cord-333672-ef53l283 278 29 ( ( -LRB- cord-333672-ef53l283 278 30 42 42 CD cord-333672-ef53l283 278 31 ) ) -RRB- cord-333672-ef53l283 278 32 . . . cord-333672-ef53l283 279 1 It -PRON- PRP cord-333672-ef53l283 279 2 is be VBZ cord-333672-ef53l283 279 3 encouraging encouraging JJ cord-333672-ef53l283 279 4 that that IN cord-333672-ef53l283 279 5 many many JJ cord-333672-ef53l283 279 6 workers worker NNS cord-333672-ef53l283 279 7 do do VBP cord-333672-ef53l283 279 8 select select VB cord-333672-ef53l283 279 9 healthier healthy JJR cord-333672-ef53l283 279 10 dietary dietary JJ cord-333672-ef53l283 279 11 choices choice NNS cord-333672-ef53l283 279 12 when when WRB cord-333672-ef53l283 279 13 they -PRON- PRP cord-333672-ef53l283 279 14 are be VBP cord-333672-ef53l283 279 15 available available JJ cord-333672-ef53l283 279 16 in in IN cord-333672-ef53l283 279 17 vending vend VBG cord-333672-ef53l283 279 18 machines machine NNS cord-333672-ef53l283 279 19 , , , cord-333672-ef53l283 279 20 providing provide VBG cord-333672-ef53l283 279 21 an an DT cord-333672-ef53l283 279 22 opportunity opportunity NN cord-333672-ef53l283 279 23 for for IN cord-333672-ef53l283 279 24 organisations organisation NNS cord-333672-ef53l283 279 25 to to TO cord-333672-ef53l283 279 26 positively positively RB cord-333672-ef53l283 279 27 affect affect VB cord-333672-ef53l283 279 28 their -PRON- PRP$ cord-333672-ef53l283 279 29 employees employee NNS cord-333672-ef53l283 279 30 ' ' POS cord-333672-ef53l283 279 31 health health NN cord-333672-ef53l283 279 32 decisions decision NNS cord-333672-ef53l283 279 33 ( ( -LRB- cord-333672-ef53l283 279 34 131 131 CD cord-333672-ef53l283 279 35 ) ) -RRB- cord-333672-ef53l283 279 36 . . . cord-333672-ef53l283 280 1 Furthermore furthermore RB cord-333672-ef53l283 280 2 , , , cord-333672-ef53l283 280 3 workplace workplace NN cord-333672-ef53l283 280 4 interventions intervention NNS cord-333672-ef53l283 280 5 to to TO cord-333672-ef53l283 280 6 promote promote VB cord-333672-ef53l283 280 7 healthier healthy JJR cord-333672-ef53l283 280 8 diets diet NNS cord-333672-ef53l283 280 9 , , , cord-333672-ef53l283 280 10 such such JJ cord-333672-ef53l283 280 11 as as IN cord-333672-ef53l283 280 12 offering offer VBG cord-333672-ef53l283 280 13 free free JJ cord-333672-ef53l283 280 14 fruit fruit NN cord-333672-ef53l283 280 15 and and CC cord-333672-ef53l283 280 16 labelling labelling NN cord-333672-ef53l283 280 17 meals meal NNS cord-333672-ef53l283 280 18 , , , cord-333672-ef53l283 280 19 have have VBP cord-333672-ef53l283 280 20 sometimes sometimes RB cord-333672-ef53l283 280 21 been be VBN cord-333672-ef53l283 280 22 shown show VBN cord-333672-ef53l283 280 23 to to TO cord-333672-ef53l283 280 24 facilitate facilitate VB cord-333672-ef53l283 280 25 healthy healthy JJ cord-333672-ef53l283 280 26 dietary dietary JJ cord-333672-ef53l283 280 27 choices choice NNS cord-333672-ef53l283 280 28 ( ( -LRB- cord-333672-ef53l283 280 29 132 132 CD cord-333672-ef53l283 280 30 , , , cord-333672-ef53l283 280 31 133 133 CD cord-333672-ef53l283 280 32 ) ) -RRB- cord-333672-ef53l283 280 33 . . . cord-333672-ef53l283 281 1 Simple simple JJ cord-333672-ef53l283 281 2 changes change NNS cord-333672-ef53l283 281 3 in in IN cord-333672-ef53l283 281 4 the the DT cord-333672-ef53l283 281 5 placement placement NN cord-333672-ef53l283 281 6 of of IN cord-333672-ef53l283 281 7 food food NN cord-333672-ef53l283 281 8 in in IN cord-333672-ef53l283 281 9 eating eat VBG cord-333672-ef53l283 281 10 areas area NNS cord-333672-ef53l283 281 11 affect affect VBP cord-333672-ef53l283 281 12 food food NN cord-333672-ef53l283 281 13 selection selection NN cord-333672-ef53l283 281 14 too too RB cord-333672-ef53l283 281 15 ( ( -LRB- cord-333672-ef53l283 281 16 134 134 CD cord-333672-ef53l283 281 17 ) ) -RRB- cord-333672-ef53l283 281 18 , , , cord-333672-ef53l283 281 19 and and CC cord-333672-ef53l283 281 20 these these DT cord-333672-ef53l283 281 21 changes change NNS cord-333672-ef53l283 281 22 can can MD cord-333672-ef53l283 281 23 be be VB cord-333672-ef53l283 281 24 leveraged leverage VBN cord-333672-ef53l283 281 25 to to TO cord-333672-ef53l283 281 26 support support VB cord-333672-ef53l283 281 27 the the DT cord-333672-ef53l283 281 28 health health NN cord-333672-ef53l283 281 29 of of IN cord-333672-ef53l283 281 30 shift shift NN cord-333672-ef53l283 281 31 workers worker NNS cord-333672-ef53l283 281 32 . . . cord-333672-ef53l283 282 1 Similarly similarly RB cord-333672-ef53l283 282 2 , , , cord-333672-ef53l283 282 3 if if IN cord-333672-ef53l283 282 4 workers worker NNS cord-333672-ef53l283 282 5 are be VBP cord-333672-ef53l283 282 6 using use VBG cord-333672-ef53l283 282 7 products product NNS cord-333672-ef53l283 282 8 such such JJ cord-333672-ef53l283 282 9 as as IN cord-333672-ef53l283 282 10 melatonin melatonin NN cord-333672-ef53l283 282 11 supplements supplement NNS cord-333672-ef53l283 282 12 and and CC cord-333672-ef53l283 282 13 blue blue JJ cord-333672-ef53l283 282 14 - - HYPH cord-333672-ef53l283 282 15 light light NN cord-333672-ef53l283 282 16 - - HYPH cord-333672-ef53l283 282 17 blocking block VBG cord-333672-ef53l283 282 18 glasses glass NNS cord-333672-ef53l283 282 19 to to TO cord-333672-ef53l283 282 20 shift shift VB cord-333672-ef53l283 282 21 the the DT cord-333672-ef53l283 282 22 phases phase NNS cord-333672-ef53l283 282 23 of of IN cord-333672-ef53l283 282 24 their -PRON- PRP$ cord-333672-ef53l283 282 25 circadian circadian NN cord-333672-ef53l283 282 26 systems system NNS cord-333672-ef53l283 282 27 , , , cord-333672-ef53l283 282 28 it -PRON- PRP cord-333672-ef53l283 282 29 makes make VBZ cord-333672-ef53l283 282 30 sense sense NN cord-333672-ef53l283 282 31 to to TO cord-333672-ef53l283 282 32 help help VB cord-333672-ef53l283 282 33 them -PRON- PRP cord-333672-ef53l283 282 34 acquire acquire VB cord-333672-ef53l283 282 35 efficacious efficacious JJ cord-333672-ef53l283 282 36 products product NNS cord-333672-ef53l283 282 37 . . . cord-333672-ef53l283 283 1 It -PRON- PRP cord-333672-ef53l283 283 2 is be VBZ cord-333672-ef53l283 283 3 also also RB cord-333672-ef53l283 283 4 clear clear JJ cord-333672-ef53l283 283 5 that that IN cord-333672-ef53l283 283 6 social social JJ cord-333672-ef53l283 283 7 life life NN cord-333672-ef53l283 283 8 is be VBZ cord-333672-ef53l283 283 9 a a DT cord-333672-ef53l283 283 10 strong strong JJ cord-333672-ef53l283 283 11 influence influence NN cord-333672-ef53l283 283 12 on on IN cord-333672-ef53l283 283 13 many many JJ cord-333672-ef53l283 283 14 shift shift NN cord-333672-ef53l283 283 15 workers worker NNS cord-333672-ef53l283 283 16 ' ' POS cord-333672-ef53l283 283 17 health health NN cord-333672-ef53l283 283 18 behaviours behaviour NNS cord-333672-ef53l283 283 19 , , , cord-333672-ef53l283 283 20 including include VBG cord-333672-ef53l283 283 21 their -PRON- PRP$ cord-333672-ef53l283 283 22 diets diet NNS cord-333672-ef53l283 283 23 . . . cord-333672-ef53l283 284 1 The the DT cord-333672-ef53l283 284 2 dietary dietary JJ cord-333672-ef53l283 284 3 attitudes attitude NNS cord-333672-ef53l283 284 4 and and CC cord-333672-ef53l283 284 5 preferences preference NNS cord-333672-ef53l283 284 6 of of IN cord-333672-ef53l283 284 7 co co NNS cord-333672-ef53l283 284 8 - - NNS cord-333672-ef53l283 284 9 workers worker NNS cord-333672-ef53l283 284 10 affect affect VBP cord-333672-ef53l283 284 11 some some DT cord-333672-ef53l283 284 12 workers worker NNS cord-333672-ef53l283 284 13 ' ' POS cord-333672-ef53l283 284 14 dietary dietary JJ cord-333672-ef53l283 284 15 choices choice NNS cord-333672-ef53l283 284 16 ( ( -LRB- cord-333672-ef53l283 284 17 135 135 CD cord-333672-ef53l283 284 18 ) ) -RRB- cord-333672-ef53l283 284 19 , , , cord-333672-ef53l283 284 20 so so RB cord-333672-ef53l283 284 21 group group NN cord-333672-ef53l283 284 22 commitment commitment NN cord-333672-ef53l283 284 23 to to IN cord-333672-ef53l283 284 24 healthier healthy JJR cord-333672-ef53l283 284 25 dietary dietary JJ cord-333672-ef53l283 284 26 choices choice NNS cord-333672-ef53l283 284 27 may may MD cord-333672-ef53l283 284 28 aid aid VB cord-333672-ef53l283 284 29 the the DT cord-333672-ef53l283 284 30 adoption adoption NN cord-333672-ef53l283 284 31 of of IN cord-333672-ef53l283 284 32 more more RBR cord-333672-ef53l283 284 33 nutritious nutritious JJ cord-333672-ef53l283 284 34 diets diet NNS cord-333672-ef53l283 284 35 . . . cord-333672-ef53l283 285 1 As as IN cord-333672-ef53l283 285 2 stress stress NN cord-333672-ef53l283 285 3 strongly strongly RB cord-333672-ef53l283 285 4 affects affect VBZ cord-333672-ef53l283 285 5 dietary dietary JJ cord-333672-ef53l283 285 6 choices choice NNS cord-333672-ef53l283 285 7 in in IN cord-333672-ef53l283 285 8 many many JJ cord-333672-ef53l283 285 9 people people NNS cord-333672-ef53l283 285 10 and and CC cord-333672-ef53l283 285 11 shift shift VB cord-333672-ef53l283 285 12 workers worker NNS cord-333672-ef53l283 285 13 often often RB cord-333672-ef53l283 285 14 report report VBP cord-333672-ef53l283 285 15 high high JJ cord-333672-ef53l283 285 16 stress stress NN cord-333672-ef53l283 285 17 and and CC cord-333672-ef53l283 285 18 abnormal abnormal JJ cord-333672-ef53l283 285 19 dietary dietary JJ cord-333672-ef53l283 285 20 behaviours behaviour NNS cord-333672-ef53l283 285 21 ( ( -LRB- cord-333672-ef53l283 285 22 136 136 CD cord-333672-ef53l283 285 23 ) ) -RRB- cord-333672-ef53l283 285 24 , , , cord-333672-ef53l283 285 25 interventions intervention NNS cord-333672-ef53l283 285 26 to to TO cord-333672-ef53l283 285 27 nurture nurture VB cord-333672-ef53l283 285 28 the the DT cord-333672-ef53l283 285 29 resilience resilience NN cord-333672-ef53l283 285 30 of of IN cord-333672-ef53l283 285 31 shift shift NN cord-333672-ef53l283 285 32 workers worker NNS cord-333672-ef53l283 285 33 and and CC cord-333672-ef53l283 285 34 to to TO cord-333672-ef53l283 285 35 improve improve VB cord-333672-ef53l283 285 36 workers worker NNS cord-333672-ef53l283 285 37 ' ' POS cord-333672-ef53l283 285 38 self self NN cord-333672-ef53l283 285 39 - - HYPH cord-333672-ef53l283 285 40 regulation regulation NN cord-333672-ef53l283 285 41 skills skill NNS cord-333672-ef53l283 285 42 may may MD cord-333672-ef53l283 285 43 support support VB cord-333672-ef53l283 285 44 their -PRON- PRP$ cord-333672-ef53l283 285 45 dietary dietary JJ cord-333672-ef53l283 285 46 choices choice NNS cord-333672-ef53l283 285 47 . . . cord-333672-ef53l283 286 1 Such such JJ cord-333672-ef53l283 286 2 interventions intervention NNS cord-333672-ef53l283 286 3 include include VBP cord-333672-ef53l283 286 4 mindfulnessbased mindfulnessbase VBN cord-333672-ef53l283 286 5 approaches approach NNS cord-333672-ef53l283 286 6 ( ( -LRB- cord-333672-ef53l283 286 7 137 137 CD cord-333672-ef53l283 286 8 ) ) -RRB- cord-333672-ef53l283 286 9 . . . cord-333672-ef53l283 287 1 Shift shift JJ cord-333672-ef53l283 287 2 workers worker NNS cord-333672-ef53l283 287 3 could could MD cord-333672-ef53l283 287 4 also also RB cord-333672-ef53l283 287 5 benefit benefit VB cord-333672-ef53l283 287 6 from from IN cord-333672-ef53l283 287 7 other other JJ cord-333672-ef53l283 287 8 types type NNS cord-333672-ef53l283 287 9 of of IN cord-333672-ef53l283 287 10 social social JJ cord-333672-ef53l283 287 11 support support NN cord-333672-ef53l283 287 12 , , , cord-333672-ef53l283 287 13 including include VBG cord-333672-ef53l283 287 14 provision provision NN cord-333672-ef53l283 287 15 of of IN cord-333672-ef53l283 287 16 additional additional JJ cord-333672-ef53l283 287 17 childcare childcare NN cord-333672-ef53l283 287 18 , , , cord-333672-ef53l283 287 19 as as RB cord-333672-ef53l283 287 20 well well RB cord-333672-ef53l283 287 21 as as IN cord-333672-ef53l283 287 22 groups group NNS cord-333672-ef53l283 287 23 and and CC cord-333672-ef53l283 287 24 events event NNS cord-333672-ef53l283 287 25 designed design VBN cord-333672-ef53l283 287 26 to to TO cord-333672-ef53l283 287 27 minimise minimise VB cord-333672-ef53l283 287 28 conflicts conflict NNS cord-333672-ef53l283 287 29 between between IN cord-333672-ef53l283 287 30 their -PRON- PRP$ cord-333672-ef53l283 287 31 work work NN cord-333672-ef53l283 287 32 and and CC cord-333672-ef53l283 287 33 non non JJ cord-333672-ef53l283 287 34 - - JJ cord-333672-ef53l283 287 35 work work JJ cord-333672-ef53l283 287 36 activities activity NNS cord-333672-ef53l283 287 37 . . . cord-333672-ef53l283 288 1 Educating educate VBG cord-333672-ef53l283 288 2 shift shift NN cord-333672-ef53l283 288 3 workers worker NNS cord-333672-ef53l283 288 4 about about IN cord-333672-ef53l283 288 5 how how WRB cord-333672-ef53l283 288 6 to to TO cord-333672-ef53l283 288 7 sleep sleep VB cord-333672-ef53l283 288 8 better well JJR cord-333672-ef53l283 288 9 is be VBZ cord-333672-ef53l283 288 10 likely likely JJ cord-333672-ef53l283 288 11 to to TO cord-333672-ef53l283 288 12 be be VB cord-333672-ef53l283 288 13 pivotal pivotal JJ cord-333672-ef53l283 288 14 to to IN cord-333672-ef53l283 288 15 their -PRON- PRP$ cord-333672-ef53l283 288 16 well well NN cord-333672-ef53l283 288 17 - - HYPH cord-333672-ef53l283 288 18 being being NN cord-333672-ef53l283 288 19 , , , cord-333672-ef53l283 288 20 and and CC cord-333672-ef53l283 288 21 shift shift VB cord-333672-ef53l283 288 22 work work NN cord-333672-ef53l283 288 23 workplaces workplace NNS cord-333672-ef53l283 288 24 should should MD cord-333672-ef53l283 288 25 have have VB cord-333672-ef53l283 288 26 spaces space NNS cord-333672-ef53l283 288 27 for for IN cord-333672-ef53l283 288 28 sleepy sleepy JJ cord-333672-ef53l283 288 29 workers worker NNS cord-333672-ef53l283 288 30 to to TO cord-333672-ef53l283 288 31 nap nap VB cord-333672-ef53l283 288 32 . . . cord-333672-ef53l283 289 1 It -PRON- PRP cord-333672-ef53l283 289 2 is be VBZ cord-333672-ef53l283 289 3 of of IN cord-333672-ef53l283 289 4 course course NN cord-333672-ef53l283 289 5 important important JJ cord-333672-ef53l283 289 6 to to TO cord-333672-ef53l283 289 7 identify identify VB cord-333672-ef53l283 289 8 workers worker NNS cord-333672-ef53l283 289 9 who who WP cord-333672-ef53l283 289 10 have have VBP cord-333672-ef53l283 289 11 sleep sleep NN cord-333672-ef53l283 289 12 disorders disorder NNS cord-333672-ef53l283 289 13 too too RB cord-333672-ef53l283 289 14 , , , cord-333672-ef53l283 289 15 and and CC cord-333672-ef53l283 289 16 simple simple JJ cord-333672-ef53l283 289 17 screening screening NN cord-333672-ef53l283 289 18 tools tool NNS cord-333672-ef53l283 289 19 such such JJ cord-333672-ef53l283 289 20 as as IN cord-333672-ef53l283 289 21 brief brief JJ cord-333672-ef53l283 289 22 questionnaires questionnaire NNS cord-333672-ef53l283 289 23 can can MD cord-333672-ef53l283 289 24 be be VB cord-333672-ef53l283 289 25 used use VBN cord-333672-ef53l283 289 26 for for IN cord-333672-ef53l283 289 27 this this DT cord-333672-ef53l283 289 28 ( ( -LRB- cord-333672-ef53l283 289 29 138 138 CD cord-333672-ef53l283 289 30 ) ) -RRB- cord-333672-ef53l283 289 31 . . . cord-333672-ef53l283 290 1 It -PRON- PRP cord-333672-ef53l283 290 2 may may MD cord-333672-ef53l283 290 3 too too RB cord-333672-ef53l283 290 4 be be VB cord-333672-ef53l283 290 5 useful useful JJ cord-333672-ef53l283 290 6 to to TO cord-333672-ef53l283 290 7 screen screen VB cord-333672-ef53l283 290 8 for for IN cord-333672-ef53l283 290 9 people people NNS cord-333672-ef53l283 290 10 who who WP cord-333672-ef53l283 290 11 are be VBP cord-333672-ef53l283 290 12 simply simply RB cord-333672-ef53l283 290 13 not not RB cord-333672-ef53l283 290 14 suited suited JJ cord-333672-ef53l283 290 15 to to IN cord-333672-ef53l283 290 16 certain certain JJ cord-333672-ef53l283 290 17 shift shift NN cord-333672-ef53l283 290 18 schedules schedule NNS cord-333672-ef53l283 290 19 , , , cord-333672-ef53l283 290 20 for for IN cord-333672-ef53l283 290 21 people people NNS cord-333672-ef53l283 290 22 differ differ VBP cord-333672-ef53l283 290 23 substantially substantially RB cord-333672-ef53l283 290 24 in in IN cord-333672-ef53l283 290 25 how how WRB cord-333672-ef53l283 290 26 they -PRON- PRP cord-333672-ef53l283 290 27 tolerate tolerate VBP cord-333672-ef53l283 290 28 shift shift JJ cord-333672-ef53l283 290 29 work work NN cord-333672-ef53l283 290 30 . . . cord-333672-ef53l283 291 1 Certain certain JJ cord-333672-ef53l283 291 2 characteristics characteristic NNS cord-333672-ef53l283 291 3 associate associate VBP cord-333672-ef53l283 291 4 with with IN cord-333672-ef53l283 291 5 better well JJR cord-333672-ef53l283 291 6 shift shift NN cord-333672-ef53l283 291 7 work work NN cord-333672-ef53l283 291 8 tolerance tolerance NN cord-333672-ef53l283 291 9 , , , cord-333672-ef53l283 291 10 including include VBG cord-333672-ef53l283 291 11 robust robust JJ cord-333672-ef53l283 291 12 general general JJ cord-333672-ef53l283 291 13 health health NN cord-333672-ef53l283 291 14 ; ; , cord-333672-ef53l283 291 15 young young JJ cord-333672-ef53l283 291 16 age age NN cord-333672-ef53l283 291 17 ; ; , cord-333672-ef53l283 291 18 male male JJ cord-333672-ef53l283 291 19 sex sex NN cord-333672-ef53l283 291 20 ; ; : cord-333672-ef53l283 291 21 not not RB cord-333672-ef53l283 291 22 having have VBG cord-333672-ef53l283 291 23 children child NNS cord-333672-ef53l283 291 24 ; ; : cord-333672-ef53l283 291 25 low low JJ cord-333672-ef53l283 291 26 languidity languidity NN cord-333672-ef53l283 291 27 and and CC cord-333672-ef53l283 291 28 neuroticism neuroticism NN cord-333672-ef53l283 291 29 ; ; : cord-333672-ef53l283 291 30 high high JJ cord-333672-ef53l283 291 31 extraversion extraversion NN cord-333672-ef53l283 291 32 , , , cord-333672-ef53l283 291 33 flexibility flexibility NN cord-333672-ef53l283 291 34 in in IN cord-333672-ef53l283 291 35 sleeping sleep VBG cord-333672-ef53l283 291 36 habits habit NNS cord-333672-ef53l283 291 37 , , , cord-333672-ef53l283 291 38 and and CC cord-333672-ef53l283 291 39 internal internal JJ cord-333672-ef53l283 291 40 locus locus NN cord-333672-ef53l283 291 41 of of IN cord-333672-ef53l283 291 42 control control NN cord-333672-ef53l283 291 43 ; ; : cord-333672-ef53l283 291 44 and and CC cord-333672-ef53l283 291 45 a a DT cord-333672-ef53l283 291 46 chronotype chronotype NN cord-333672-ef53l283 291 47 that that WDT cord-333672-ef53l283 291 48 is be VBZ cord-333672-ef53l283 291 49 neither neither CC cord-333672-ef53l283 291 50 very very RB cord-333672-ef53l283 291 51 early early JJ cord-333672-ef53l283 291 52 nor nor CC cord-333672-ef53l283 291 53 very very RB cord-333672-ef53l283 291 54 late late JJ cord-333672-ef53l283 291 55 ( ( -LRB- cord-333672-ef53l283 291 56 18 18 CD cord-333672-ef53l283 291 57 ) ) -RRB- cord-333672-ef53l283 291 58 . . . cord-333672-ef53l283 292 1 Promisingly promisingly RB cord-333672-ef53l283 292 2 , , , cord-333672-ef53l283 292 3 personalising personalise VBG cord-333672-ef53l283 292 4 shift shift NN cord-333672-ef53l283 292 5 work work NN cord-333672-ef53l283 292 6 schedules schedule NNS cord-333672-ef53l283 292 7 by by IN cord-333672-ef53l283 292 8 removing remove VBG cord-333672-ef53l283 292 9 night night NN cord-333672-ef53l283 292 10 shifts shift NNS cord-333672-ef53l283 292 11 for for IN cord-333672-ef53l283 292 12 early early JJ cord-333672-ef53l283 292 13 chronotypes chronotypes NN cord-333672-ef53l283 292 14 and and CC cord-333672-ef53l283 292 15 excluding exclude VBG cord-333672-ef53l283 292 16 morning morning NN cord-333672-ef53l283 292 17 shifts shift NNS cord-333672-ef53l283 292 18 for for IN cord-333672-ef53l283 292 19 late late JJ cord-333672-ef53l283 292 20 chronotypes chronotypes NNP cord-333672-ef53l283 292 21 has have VBZ cord-333672-ef53l283 292 22 been be VBN cord-333672-ef53l283 292 23 shown show VBN cord-333672-ef53l283 292 24 to to TO cord-333672-ef53l283 292 25 prolong prolong VB cord-333672-ef53l283 292 26 selfreported selfreported JJ cord-333672-ef53l283 292 27 sleep sleep NN cord-333672-ef53l283 292 28 , , , cord-333672-ef53l283 292 29 improve improve VB cord-333672-ef53l283 292 30 subjective subjective JJ cord-333672-ef53l283 292 31 sleep sleep NN cord-333672-ef53l283 292 32 quality quality NN cord-333672-ef53l283 292 33 , , , cord-333672-ef53l283 292 34 and and CC cord-333672-ef53l283 292 35 enhance enhance VB cord-333672-ef53l283 292 36 worker worker NN cord-333672-ef53l283 292 37 well well RB cord-333672-ef53l283 292 38 - - HYPH cord-333672-ef53l283 292 39 being being NN cord-333672-ef53l283 292 40 ( ( -LRB- cord-333672-ef53l283 292 41 139 139 CD cord-333672-ef53l283 292 42 ) ) -RRB- cord-333672-ef53l283 292 43 . . . cord-333672-ef53l283 293 1 To to TO cord-333672-ef53l283 293 2 estimate estimate VB cord-333672-ef53l283 293 3 chronotype chronotype NN cord-333672-ef53l283 293 4 , , , cord-333672-ef53l283 293 5 a a DT cord-333672-ef53l283 293 6 study study NN cord-333672-ef53l283 293 7 by by IN cord-333672-ef53l283 293 8 Vetter Vetter NNP cord-333672-ef53l283 293 9 and and CC cord-333672-ef53l283 293 10 colleagues colleague NNS cord-333672-ef53l283 293 11 used use VBD cord-333672-ef53l283 293 12 a a DT cord-333672-ef53l283 293 13 shift shift NN cord-333672-ef53l283 293 14 work work NN cord-333672-ef53l283 293 15 - - HYPH cord-333672-ef53l283 293 16 specific specific JJ cord-333672-ef53l283 293 17 version version NN cord-333672-ef53l283 293 18 of of IN cord-333672-ef53l283 293 19 the the DT cord-333672-ef53l283 293 20 Munich Munich NNP cord-333672-ef53l283 293 21 Chronotype Chronotype NNP cord-333672-ef53l283 293 22 Questionnaire Questionnaire NNP cord-333672-ef53l283 293 23 ( ( -LRB- cord-333672-ef53l283 293 24 140 140 CD cord-333672-ef53l283 293 25 ) ) -RRB- cord-333672-ef53l283 293 26 , , , cord-333672-ef53l283 293 27 and and CC cord-333672-ef53l283 293 28 this this DT cord-333672-ef53l283 293 29 approach approach NN cord-333672-ef53l283 293 30 may may MD cord-333672-ef53l283 293 31 be be VB cord-333672-ef53l283 293 32 useful useful JJ cord-333672-ef53l283 293 33 to to TO cord-333672-ef53l283 293 34 help help VB cord-333672-ef53l283 293 35 personalise personalise VB cord-333672-ef53l283 293 36 work work NN cord-333672-ef53l283 293 37 schedules schedule NNS cord-333672-ef53l283 293 38 for for IN cord-333672-ef53l283 293 39 shift shift NN cord-333672-ef53l283 293 40 workers worker NNS cord-333672-ef53l283 293 41 . . . cord-333672-ef53l283 294 1 Nonetheless nonetheless RB cord-333672-ef53l283 294 2 , , , cord-333672-ef53l283 294 3 it -PRON- PRP cord-333672-ef53l283 294 4 would would MD cord-333672-ef53l283 294 5 be be VB cord-333672-ef53l283 294 6 useful useful JJ cord-333672-ef53l283 294 7 to to TO cord-333672-ef53l283 294 8 develop develop VB cord-333672-ef53l283 294 9 additional additional JJ cord-333672-ef53l283 294 10 questionnaires questionnaire NNS cord-333672-ef53l283 294 11 designed design VBN cord-333672-ef53l283 294 12 specifically specifically RB cord-333672-ef53l283 294 13 to to TO cord-333672-ef53l283 294 14 identify identify VB cord-333672-ef53l283 294 15 appropriate appropriate JJ cord-333672-ef53l283 294 16 shift shift NN cord-333672-ef53l283 294 17 schedules schedule NNS cord-333672-ef53l283 294 18 , , , cord-333672-ef53l283 294 19 as as RB cord-333672-ef53l283 294 20 well well RB cord-333672-ef53l283 294 21 as as IN cord-333672-ef53l283 294 22 to to TO cord-333672-ef53l283 294 23 track track VB cord-333672-ef53l283 294 24 how how WRB cord-333672-ef53l283 294 25 workers worker NNS cord-333672-ef53l283 294 26 respond respond VBP cord-333672-ef53l283 294 27 to to IN cord-333672-ef53l283 294 28 these these DT cord-333672-ef53l283 294 29 schedules schedule NNS cord-333672-ef53l283 294 30 . . . cord-333672-ef53l283 295 1 Finally finally RB cord-333672-ef53l283 295 2 , , , cord-333672-ef53l283 295 3 it -PRON- PRP cord-333672-ef53l283 295 4 is be VBZ cord-333672-ef53l283 295 5 worth worth JJ cord-333672-ef53l283 295 6 noting note VBG cord-333672-ef53l283 295 7 that that IN cord-333672-ef53l283 295 8 many many JJ cord-333672-ef53l283 295 9 workplace workplace NN cord-333672-ef53l283 295 10 wellness wellness NN cord-333672-ef53l283 295 11 programmes programme NNS cord-333672-ef53l283 295 12 that that WDT cord-333672-ef53l283 295 13 have have VBP cord-333672-ef53l283 295 14 been be VBN cord-333672-ef53l283 295 15 tested test VBN cord-333672-ef53l283 295 16 have have VBP cord-333672-ef53l283 295 17 not not RB cord-333672-ef53l283 295 18 yielded yield VBN cord-333672-ef53l283 295 19 impressive impressive JJ cord-333672-ef53l283 295 20 results result NNS cord-333672-ef53l283 295 21 ( ( -LRB- cord-333672-ef53l283 295 22 141 141 CD cord-333672-ef53l283 295 23 ) ) -RRB- cord-333672-ef53l283 295 24 . . . cord-333672-ef53l283 296 1 Assessing assess VBG cord-333672-ef53l283 296 2 the the DT cord-333672-ef53l283 296 3 effects effect NNS cord-333672-ef53l283 296 4 of of IN cord-333672-ef53l283 296 5 workplace workplace NN cord-333672-ef53l283 296 6 interventions intervention NNS cord-333672-ef53l283 296 7 is be VBZ cord-333672-ef53l283 296 8 difficult difficult JJ cord-333672-ef53l283 296 9 for for IN cord-333672-ef53l283 296 10 numerous numerous JJ cord-333672-ef53l283 296 11 reasons reason NNS cord-333672-ef53l283 296 12 , , , cord-333672-ef53l283 296 13 not not RB cord-333672-ef53l283 296 14 the the DT cord-333672-ef53l283 296 15 least least JJS cord-333672-ef53l283 296 16 of of IN cord-333672-ef53l283 296 17 which which WDT cord-333672-ef53l283 296 18 are be VBP cord-333672-ef53l283 296 19 enforcing enforce VBG cord-333672-ef53l283 296 20 blinding blinding NN cord-333672-ef53l283 296 21 and and CC cord-333672-ef53l283 296 22 randomisation randomisation NN cord-333672-ef53l283 296 23 of of IN cord-333672-ef53l283 296 24 participants participant NNS cord-333672-ef53l283 296 25 . . . cord-333672-ef53l283 297 1 To to IN cord-333672-ef53l283 297 2 date date NN cord-333672-ef53l283 297 3 , , , cord-333672-ef53l283 297 4 marked mark VBD cord-333672-ef53l283 297 5 heterogeneity heterogeneity NN cord-333672-ef53l283 297 6 between between IN cord-333672-ef53l283 297 7 studies study NNS cord-333672-ef53l283 297 8 has have VBZ cord-333672-ef53l283 297 9 made make VBN cord-333672-ef53l283 297 10 it -PRON- PRP cord-333672-ef53l283 297 11 challenging challenging JJ cord-333672-ef53l283 297 12 to to TO cord-333672-ef53l283 297 13 assess assess VB cord-333672-ef53l283 297 14 the the DT cord-333672-ef53l283 297 15 utility utility NN cord-333672-ef53l283 297 16 of of IN cord-333672-ef53l283 297 17 workplace workplace NN cord-333672-ef53l283 297 18 interventions intervention NNS cord-333672-ef53l283 297 19 for for IN cord-333672-ef53l283 297 20 shift shift NN cord-333672-ef53l283 297 21 workers worker NNS cord-333672-ef53l283 297 22 ( ( -LRB- cord-333672-ef53l283 297 23 30 30 CD cord-333672-ef53l283 297 24 ) ) -RRB- cord-333672-ef53l283 297 25 . . . cord-333672-ef53l283 298 1 And and CC cord-333672-ef53l283 298 2 as as IN cord-333672-ef53l283 298 3 is be VBZ cord-333672-ef53l283 298 4 so so RB cord-333672-ef53l283 298 5 often often RB cord-333672-ef53l283 298 6 the the DT cord-333672-ef53l283 298 7 case case NN cord-333672-ef53l283 298 8 , , , cord-333672-ef53l283 298 9 the the DT cord-333672-ef53l283 298 10 participants participant NNS cord-333672-ef53l283 298 11 included include VBN cord-333672-ef53l283 298 12 in in IN cord-333672-ef53l283 298 13 many many JJ cord-333672-ef53l283 298 14 of of IN cord-333672-ef53l283 298 15 these these DT cord-333672-ef53l283 298 16 studies study NNS cord-333672-ef53l283 298 17 did do VBD cord-333672-ef53l283 298 18 not not RB cord-333672-ef53l283 298 19 comprise comprise VB cord-333672-ef53l283 298 20 a a DT cord-333672-ef53l283 298 21 diversity diversity NN cord-333672-ef53l283 298 22 of of IN cord-333672-ef53l283 298 23 ages age NNS cord-333672-ef53l283 298 24 and and CC cord-333672-ef53l283 298 25 races race NNS cord-333672-ef53l283 298 26 , , , cord-333672-ef53l283 298 27 nor nor CC cord-333672-ef53l283 298 28 did do VBD cord-333672-ef53l283 298 29 the the DT cord-333672-ef53l283 298 30 scientists scientist NNS cord-333672-ef53l283 298 31 attempt attempt VB cord-333672-ef53l283 298 32 to to TO cord-333672-ef53l283 298 33 define define VB cord-333672-ef53l283 298 34 determinants determinant NNS cord-333672-ef53l283 298 35 of of IN cord-333672-ef53l283 298 36 which which WDT cord-333672-ef53l283 298 37 workers worker NNS cord-333672-ef53l283 298 38 responded respond VBD cord-333672-ef53l283 298 39 positively positively RB cord-333672-ef53l283 298 40 to to IN cord-333672-ef53l283 298 41 the the DT cord-333672-ef53l283 298 42 interventions intervention NNS cord-333672-ef53l283 298 43 . . . cord-333672-ef53l283 299 1 None none NN cord-333672-ef53l283 299 2 of of IN cord-333672-ef53l283 299 3 this this DT cord-333672-ef53l283 299 4 means mean VBZ cord-333672-ef53l283 299 5 that that IN cord-333672-ef53l283 299 6 it -PRON- PRP cord-333672-ef53l283 299 7 is be VBZ cord-333672-ef53l283 299 8 not not RB cord-333672-ef53l283 299 9 possible possible JJ cord-333672-ef53l283 299 10 to to TO cord-333672-ef53l283 299 11 implement implement VB cord-333672-ef53l283 299 12 effective effective JJ cord-333672-ef53l283 299 13 programmes programme NNS cord-333672-ef53l283 299 14 , , , cord-333672-ef53l283 299 15 however however RB cord-333672-ef53l283 299 16 , , , cord-333672-ef53l283 299 17 and and CC cord-333672-ef53l283 300 1 we -PRON- PRP cord-333672-ef53l283 300 2 hope hope VBP cord-333672-ef53l283 300 3 that that IN cord-333672-ef53l283 300 4 lacklustre lacklustre JJ cord-333672-ef53l283 300 5 results result NNS cord-333672-ef53l283 300 6 to to IN cord-333672-ef53l283 300 7 date date NN cord-333672-ef53l283 300 8 do do VBP cord-333672-ef53l283 300 9 not not RB cord-333672-ef53l283 300 10 stymie stymie VB cord-333672-ef53l283 300 11 continued continued JJ cord-333672-ef53l283 300 12 efforts effort NNS cord-333672-ef53l283 300 13 to to TO cord-333672-ef53l283 300 14 improve improve VB cord-333672-ef53l283 300 15 on on IN cord-333672-ef53l283 300 16 workplace workplace NN cord-333672-ef53l283 300 17 interventions intervention NNS cord-333672-ef53l283 300 18 by by IN cord-333672-ef53l283 300 19 better well RBR cord-333672-ef53l283 300 20 incorporating incorporate VBG cord-333672-ef53l283 300 21 principles principle NNS cord-333672-ef53l283 300 22 from from IN cord-333672-ef53l283 300 23 behavioural behavioural JJ cord-333672-ef53l283 300 24 science science NN cord-333672-ef53l283 300 25 . . . cord-333672-ef53l283 301 1 To to TO cord-333672-ef53l283 301 2 assess assess VB cord-333672-ef53l283 301 3 the the DT cord-333672-ef53l283 301 4 efficacy efficacy NN cord-333672-ef53l283 301 5 of of IN cord-333672-ef53l283 301 6 interventions intervention NNS cord-333672-ef53l283 301 7 to to TO cord-333672-ef53l283 301 8 improve improve VB cord-333672-ef53l283 301 9 shift shift JJ cord-333672-ef53l283 301 10 - - JJ cord-333672-ef53l283 301 11 worker worker NN cord-333672-ef53l283 301 12 health health NN cord-333672-ef53l283 301 13 , , , cord-333672-ef53l283 301 14 it -PRON- PRP cord-333672-ef53l283 301 15 may may MD cord-333672-ef53l283 301 16 make make VB cord-333672-ef53l283 301 17 sense sense NN cord-333672-ef53l283 301 18 to to TO cord-333672-ef53l283 301 19 use use VB cord-333672-ef53l283 301 20 alternatives alternative NNS cord-333672-ef53l283 301 21 to to IN cord-333672-ef53l283 301 22 many many JJ cord-333672-ef53l283 301 23 of of IN cord-333672-ef53l283 301 24 the the DT cord-333672-ef53l283 301 25 hitherto hitherto RB cord-333672-ef53l283 301 26 - - HYPH cord-333672-ef53l283 301 27 used use VBN cord-333672-ef53l283 301 28 study study NN cord-333672-ef53l283 301 29 designs design NNS cord-333672-ef53l283 301 30 . . . cord-333672-ef53l283 302 1 Recently recently RB cord-333672-ef53l283 302 2 , , , cord-333672-ef53l283 302 3 studies study NNS cord-333672-ef53l283 302 4 applying apply VBG cord-333672-ef53l283 302 5 " " `` cord-333672-ef53l283 302 6 Big Big NNP cord-333672-ef53l283 302 7 Data datum NNS cord-333672-ef53l283 302 8 " " '' cord-333672-ef53l283 302 9 approaches approach NNS cord-333672-ef53l283 302 10 have have VBP cord-333672-ef53l283 302 11 contributed contribute VBN cord-333672-ef53l283 302 12 to to IN cord-333672-ef53l283 302 13 some some DT cord-333672-ef53l283 302 14 advances advance NNS cord-333672-ef53l283 302 15 in in IN cord-333672-ef53l283 302 16 efforts effort NNS cord-333672-ef53l283 302 17 to to TO cord-333672-ef53l283 302 18 personalise personalise VB cord-333672-ef53l283 302 19 medicine medicine NN cord-333672-ef53l283 302 20 . . . cord-333672-ef53l283 303 1 However however RB cord-333672-ef53l283 303 2 , , , cord-333672-ef53l283 303 3 it -PRON- PRP cord-333672-ef53l283 303 4 may may MD cord-333672-ef53l283 303 5 be be VB cord-333672-ef53l283 303 6 advantageous advantageous JJ cord-333672-ef53l283 303 7 to to TO cord-333672-ef53l283 303 8 concurrently concurrently RB cord-333672-ef53l283 303 9 carry carry VB cord-333672-ef53l283 303 10 out out RP cord-333672-ef53l283 303 11 studies study NNS cord-333672-ef53l283 303 12 that that WDT cord-333672-ef53l283 303 13 use use VBP cord-333672-ef53l283 303 14 a a DT cord-333672-ef53l283 303 15 " " `` cord-333672-ef53l283 303 16 Small Small NNP cord-333672-ef53l283 303 17 Data Data NNP cord-333672-ef53l283 303 18 " " '' cord-333672-ef53l283 303 19 paradigmfor paradigmfor NN cord-333672-ef53l283 303 20 example example NN cord-333672-ef53l283 303 21 , , , cord-333672-ef53l283 303 22 using use VBG cord-333672-ef53l283 303 23 n n NN cord-333672-ef53l283 303 24 - - HYPH cord-333672-ef53l283 303 25 of-1 of-1 NNP cord-333672-ef53l283 304 1 approaches approach NNS cord-333672-ef53l283 304 2 to to TO cord-333672-ef53l283 304 3 more more RBR cord-333672-ef53l283 304 4 rapidly rapidly RB cord-333672-ef53l283 304 5 assess assess VB cord-333672-ef53l283 304 6 how how WRB cord-333672-ef53l283 304 7 individual individual JJ cord-333672-ef53l283 304 8 workers worker NNS cord-333672-ef53l283 304 9 are be VBP cord-333672-ef53l283 304 10 responding respond VBG cord-333672-ef53l283 304 11 to to IN cord-333672-ef53l283 304 12 a a DT cord-333672-ef53l283 304 13 given give VBN cord-333672-ef53l283 304 14 intervention intervention NN cord-333672-ef53l283 304 15 and and CC cord-333672-ef53l283 304 16 to to TO cord-333672-ef53l283 304 17 forecast forecast VB cord-333672-ef53l283 304 18 which which WDT cord-333672-ef53l283 304 19 of of IN cord-333672-ef53l283 304 20 them -PRON- PRP cord-333672-ef53l283 304 21 are be VBP cord-333672-ef53l283 304 22 at at IN cord-333672-ef53l283 304 23 risk risk NN cord-333672-ef53l283 304 24 of of IN cord-333672-ef53l283 304 25 health health NN cord-333672-ef53l283 304 26 trajectory trajectory NN cord-333672-ef53l283 304 27 transitions transition NNS cord-333672-ef53l283 304 28 towards towards IN cord-333672-ef53l283 304 29 disease disease NN cord-333672-ef53l283 304 30 ( ( -LRB- cord-333672-ef53l283 304 31 142 142 CD cord-333672-ef53l283 304 32 ) ) -RRB- cord-333672-ef53l283 304 33 . . . cord-333672-ef53l283 305 1 A a DT cord-333672-ef53l283 305 2 large large JJ cord-333672-ef53l283 305 3 proportion proportion NN cord-333672-ef53l283 305 4 of of IN cord-333672-ef53l283 305 5 the the DT cord-333672-ef53l283 305 6 workforce workforce NN cord-333672-ef53l283 305 7 works work VBZ cord-333672-ef53l283 305 8 shifts shift NNS cord-333672-ef53l283 305 9 , , , cord-333672-ef53l283 305 10 and and CC cord-333672-ef53l283 305 11 these these DT cord-333672-ef53l283 305 12 individuals individual NNS cord-333672-ef53l283 305 13 are be VBP cord-333672-ef53l283 305 14 integral integral JJ cord-333672-ef53l283 305 15 to to IN cord-333672-ef53l283 305 16 sustaining sustain VBG cord-333672-ef53l283 305 17 functional functional JJ cord-333672-ef53l283 305 18 societies society NNS cord-333672-ef53l283 305 19 . . . cord-333672-ef53l283 306 1 However however RB cord-333672-ef53l283 306 2 , , , cord-333672-ef53l283 306 3 the the DT cord-333672-ef53l283 306 4 study study NN cord-333672-ef53l283 306 5 of of IN cord-333672-ef53l283 306 6 how how WRB cord-333672-ef53l283 306 7 to to TO cord-333672-ef53l283 306 8 support support VB cord-333672-ef53l283 306 9 the the DT cord-333672-ef53l283 306 10 long long JJ cord-333672-ef53l283 306 11 - - HYPH cord-333672-ef53l283 306 12 term term NN cord-333672-ef53l283 306 13 health health NN cord-333672-ef53l283 306 14 and and CC cord-333672-ef53l283 306 15 well well RB cord-333672-ef53l283 306 16 - - HYPH cord-333672-ef53l283 306 17 being being NN cord-333672-ef53l283 306 18 of of IN cord-333672-ef53l283 306 19 these these DT cord-333672-ef53l283 306 20 people people NNS cord-333672-ef53l283 306 21 has have VBZ cord-333672-ef53l283 306 22 been be VBN cord-333672-ef53l283 306 23 somewhat somewhat RB cord-333672-ef53l283 306 24 neglected neglect VBN cord-333672-ef53l283 306 25 , , , cord-333672-ef53l283 306 26 and and CC cord-333672-ef53l283 306 27 a a DT cord-333672-ef53l283 306 28 relatively relatively RB cord-333672-ef53l283 306 29 small small JJ cord-333672-ef53l283 306 30 proportion proportion NN cord-333672-ef53l283 306 31 of of IN cord-333672-ef53l283 306 32 relevant relevant JJ cord-333672-ef53l283 306 33 studies study NNS cord-333672-ef53l283 306 34 has have VBZ cord-333672-ef53l283 306 35 included include VBN cord-333672-ef53l283 306 36 shift shift NN cord-333672-ef53l283 306 37 workers worker NNS cord-333672-ef53l283 306 38 as as IN cord-333672-ef53l283 306 39 participants participant NNS cord-333672-ef53l283 306 40 . . . cord-333672-ef53l283 307 1 While while IN cord-333672-ef53l283 307 2 the the DT cord-333672-ef53l283 307 3 type type NN cord-333672-ef53l283 307 4 of of IN cord-333672-ef53l283 307 5 personalised personalised JJ cord-333672-ef53l283 307 6 interventions intervention NNS cord-333672-ef53l283 307 7 to to TO cord-333672-ef53l283 307 8 support support VB cord-333672-ef53l283 307 9 shift shift NN cord-333672-ef53l283 307 10 workers worker NNS cord-333672-ef53l283 307 11 that that WDT cord-333672-ef53l283 307 12 we -PRON- PRP cord-333672-ef53l283 307 13 have have VBP cord-333672-ef53l283 307 14 discussed discuss VBN cord-333672-ef53l283 307 15 in in IN cord-333672-ef53l283 307 16 this this DT cord-333672-ef53l283 307 17 article article NN cord-333672-ef53l283 307 18 are be VBP cord-333672-ef53l283 307 19 bound bind VBN cord-333672-ef53l283 307 20 to to TO cord-333672-ef53l283 307 21 produce produce VB cord-333672-ef53l283 307 22 logistical logistical JJ cord-333672-ef53l283 307 23 headaches headache NNS cord-333672-ef53l283 307 24 for for IN cord-333672-ef53l283 307 25 employers employer NNS cord-333672-ef53l283 307 26 , , , cord-333672-ef53l283 307 27 the the DT cord-333672-ef53l283 307 28 onus onus NN cord-333672-ef53l283 307 29 should should MD cord-333672-ef53l283 307 30 be be VB cord-333672-ef53l283 307 31 on on IN cord-333672-ef53l283 307 32 supporting support VBG cord-333672-ef53l283 307 33 the the DT cord-333672-ef53l283 307 34 long long JJ cord-333672-ef53l283 307 35 - - HYPH cord-333672-ef53l283 307 36 term term NN cord-333672-ef53l283 307 37 the the DT cord-333672-ef53l283 307 38 health health NN cord-333672-ef53l283 307 39 and and CC cord-333672-ef53l283 307 40 performance performance NN cord-333672-ef53l283 307 41 of of IN cord-333672-ef53l283 307 42 their -PRON- PRP$ cord-333672-ef53l283 307 43 employees employee NNS cord-333672-ef53l283 307 44 . . . cord-333672-ef53l283 308 1 The the DT cord-333672-ef53l283 308 2 acute acute JJ cord-333672-ef53l283 308 3 difficulties difficulty NNS cord-333672-ef53l283 308 4 arising arise VBG cord-333672-ef53l283 308 5 from from IN cord-333672-ef53l283 308 6 implementing implement VBG cord-333672-ef53l283 308 7 customised customised JJ cord-333672-ef53l283 308 8 shift shift NN cord-333672-ef53l283 308 9 schedule schedule NN cord-333672-ef53l283 308 10 systems system NNS cord-333672-ef53l283 308 11 and and CC cord-333672-ef53l283 308 12 suchlike suchlike VBP cord-333672-ef53l283 308 13 may may MD cord-333672-ef53l283 308 14 be be VB cord-333672-ef53l283 308 15 more more JJR cord-333672-ef53l283 308 16 than than IN cord-333672-ef53l283 308 17 made make VBN cord-333672-ef53l283 308 18 up up RP cord-333672-ef53l283 308 19 for for IN cord-333672-ef53l283 308 20 by by IN cord-333672-ef53l283 308 21 the the DT cord-333672-ef53l283 308 22 lasting last VBG cord-333672-ef53l283 308 23 benefits benefit NNS cord-333672-ef53l283 308 24 of of IN cord-333672-ef53l283 308 25 these these DT cord-333672-ef53l283 308 26 systems system NNS cord-333672-ef53l283 308 27 on on IN cord-333672-ef53l283 308 28 health health NN cord-333672-ef53l283 308 29 , , , cord-333672-ef53l283 308 30 safety safety NN cord-333672-ef53l283 308 31 , , , cord-333672-ef53l283 308 32 and and CC cord-333672-ef53l283 308 33 productivity productivity NN cord-333672-ef53l283 308 34 . . . cord-333672-ef53l283 309 1 We -PRON- PRP cord-333672-ef53l283 309 2 note note VBP cord-333672-ef53l283 309 3 also also RB cord-333672-ef53l283 309 4 that that IN cord-333672-ef53l283 309 5 as as IN cord-333672-ef53l283 309 6 shift shift NN cord-333672-ef53l283 309 7 work work NN cord-333672-ef53l283 309 8 increases increase VBZ cord-333672-ef53l283 309 9 the the DT cord-333672-ef53l283 309 10 likelihood likelihood NN cord-333672-ef53l283 309 11 of of IN cord-333672-ef53l283 309 12 adverse adverse JJ cord-333672-ef53l283 309 13 pregnancy pregnancy NN cord-333672-ef53l283 309 14 outcomes outcome NNS cord-333672-ef53l283 309 15 and and CC cord-333672-ef53l283 309 16 may may MD cord-333672-ef53l283 309 17 lead lead VB cord-333672-ef53l283 309 18 to to IN cord-333672-ef53l283 309 19 epigenetic epigenetic JJ cord-333672-ef53l283 309 20 modifications modification NNS cord-333672-ef53l283 309 21 in in IN cord-333672-ef53l283 309 22 parents parent NNS cord-333672-ef53l283 309 23 that that WDT cord-333672-ef53l283 309 24 could could MD cord-333672-ef53l283 309 25 plausibly plausibly RB cord-333672-ef53l283 309 26 affect affect VB cord-333672-ef53l283 309 27 the the DT cord-333672-ef53l283 309 28 epigenetics epigenetic NNS cord-333672-ef53l283 309 29 and and CC cord-333672-ef53l283 309 30 hence hence RB cord-333672-ef53l283 309 31 health health NN cord-333672-ef53l283 309 32 of of IN cord-333672-ef53l283 309 33 their -PRON- PRP$ cord-333672-ef53l283 309 34 children child NNS cord-333672-ef53l283 309 35 , , , cord-333672-ef53l283 309 36 supporting support VBG cord-333672-ef53l283 309 37 the the DT cord-333672-ef53l283 309 38 health health NN cord-333672-ef53l283 309 39 of of IN cord-333672-ef53l283 309 40 shift shift NN cord-333672-ef53l283 309 41 workers worker NNS cord-333672-ef53l283 309 42 could could MD cord-333672-ef53l283 309 43 one one CD cord-333672-ef53l283 309 44 day day NN cord-333672-ef53l283 309 45 have have VB cord-333672-ef53l283 309 46 critical critical JJ cord-333672-ef53l283 309 47 effects effect NNS cord-333672-ef53l283 309 48 on on IN cord-333672-ef53l283 309 49 the the DT cord-333672-ef53l283 309 50 well well NN cord-333672-ef53l283 309 51 - - HYPH cord-333672-ef53l283 309 52 being being NN cord-333672-ef53l283 309 53 of of IN cord-333672-ef53l283 309 54 future future JJ cord-333672-ef53l283 309 55 generations generation NNS cord-333672-ef53l283 309 56 ( ( -LRB- cord-333672-ef53l283 309 57 143 143 CD cord-333672-ef53l283 309 58 , , , cord-333672-ef53l283 309 59 144 144 CD cord-333672-ef53l283 309 60 ) ) -RRB- cord-333672-ef53l283 309 61 . . . cord-333672-ef53l283 310 1 Scientists scientist NNS cord-333672-ef53l283 310 2 now now RB cord-333672-ef53l283 310 3 have have VBP cord-333672-ef53l283 310 4 an an DT cord-333672-ef53l283 310 5 unprecedented unprecedented JJ cord-333672-ef53l283 310 6 ability ability NN cord-333672-ef53l283 310 7 to to TO cord-333672-ef53l283 310 8 identify identify VB cord-333672-ef53l283 310 9 ways way NNS cord-333672-ef53l283 310 10 of of IN cord-333672-ef53l283 310 11 helping help VBG cord-333672-ef53l283 310 12 shift shift NN cord-333672-ef53l283 310 13 workers worker NNS cord-333672-ef53l283 310 14 . . . cord-333672-ef53l283 311 1 We -PRON- PRP cord-333672-ef53l283 311 2 hope hope VBP cord-333672-ef53l283 311 3 that that IN cord-333672-ef53l283 311 4 this this DT cord-333672-ef53l283 311 5 ability ability NN cord-333672-ef53l283 311 6 is be VBZ cord-333672-ef53l283 311 7 realised realise VBN cord-333672-ef53l283 311 8 in in IN cord-333672-ef53l283 311 9 the the DT cord-333672-ef53l283 311 10 near near JJ cord-333672-ef53l283 311 11 future future NN cord-333672-ef53l283 311 12 . . . cord-333672-ef53l283 312 1 Entrainment entrainment NN cord-333672-ef53l283 312 2 of of IN cord-333672-ef53l283 312 3 the the DT cord-333672-ef53l283 312 4 human human JJ cord-333672-ef53l283 312 5 circadian circadian NN cord-333672-ef53l283 312 6 clock clock NN cord-333672-ef53l283 312 7 to to IN cord-333672-ef53l283 312 8 the the DT cord-333672-ef53l283 312 9 natural natural JJ cord-333672-ef53l283 312 10 light light JJ cord-333672-ef53l283 312 11 - - HYPH cord-333672-ef53l283 312 12 dark dark NN cord-333672-ef53l283 312 13 cycle cycle NN cord-333672-ef53l283 312 14 Circadian circadian JJ cord-333672-ef53l283 312 15 entrainment entrainment NN cord-333672-ef53l283 312 16 to to IN cord-333672-ef53l283 312 17 the the DT cord-333672-ef53l283 312 18 natural natural JJ cord-333672-ef53l283 312 19 light light JJ cord-333672-ef53l283 312 20 - - HYPH cord-333672-ef53l283 312 21 dark dark JJ cord-333672-ef53l283 312 22 cycle cycle NN cord-333672-ef53l283 312 23 across across IN cord-333672-ef53l283 312 24 seasons season NNS cord-333672-ef53l283 312 25 and and CC cord-333672-ef53l283 312 26 the the DT cord-333672-ef53l283 312 27 weekend weekend NN cord-333672-ef53l283 313 1 Working Working NNP cord-333672-ef53l283 313 2 Group Group NNP cord-333672-ef53l283 313 3 on on IN cord-333672-ef53l283 313 4 the the DT cord-333672-ef53l283 313 5 Evaluation Evaluation NNP cord-333672-ef53l283 313 6 of of IN cord-333672-ef53l283 313 7 Carcinogenic carcinogenic JJ cord-333672-ef53l283 313 8 Risk Risk NNP cord-333672-ef53l283 313 9 to to IN cord-333672-ef53l283 313 10 Humans Humans NNPS cord-333672-ef53l283 313 11 . . . cord-333672-ef53l283 314 1 Painting painting NN cord-333672-ef53l283 314 2 , , , cord-333672-ef53l283 314 3 Firefighting firefighting NN cord-333672-ef53l283 314 4 , , , cord-333672-ef53l283 314 5 and and CC cord-333672-ef53l283 314 6 Shiftwork Shiftwork NNP cord-333672-ef53l283 314 7 Shift Shift NNP cord-333672-ef53l283 314 8 and and CC cord-333672-ef53l283 314 9 night night NN cord-333672-ef53l283 314 10 work work NN cord-333672-ef53l283 314 11 and and CC cord-333672-ef53l283 314 12 long long RB cord-333672-ef53l283 314 13 working work VBG cord-333672-ef53l283 314 14 hoursa hoursa NNP cord-333672-ef53l283 314 15 systematic systematic JJ cord-333672-ef53l283 314 16 review review NN cord-333672-ef53l283 314 17 of of IN cord-333672-ef53l283 314 18 safety safety NN cord-333672-ef53l283 314 19 implications implication NNS cord-333672-ef53l283 314 20 Health Health NNP cord-333672-ef53l283 314 21 consequences consequence NNS cord-333672-ef53l283 314 22 of of IN cord-333672-ef53l283 314 23 shift shift NN cord-333672-ef53l283 314 24 work work NN cord-333672-ef53l283 314 25 and and CC cord-333672-ef53l283 314 26 insufficient insufficient JJ cord-333672-ef53l283 314 27 sleep sleep NN cord-333672-ef53l283 315 1 Occupational occupational JJ cord-333672-ef53l283 315 2 history history NN cord-333672-ef53l283 315 3 of of IN cord-333672-ef53l283 315 4 night night NN cord-333672-ef53l283 315 5 shift shift NN cord-333672-ef53l283 315 6 work work NN cord-333672-ef53l283 315 7 and and CC cord-333672-ef53l283 315 8 parkinson parkinson NNP cord-333672-ef53l283 315 9 's 's POS cord-333672-ef53l283 315 10 disease disease NN cord-333672-ef53l283 315 11 in in IN cord-333672-ef53l283 315 12 Denmark Denmark NNP cord-333672-ef53l283 315 13 Shift Shift NNP cord-333672-ef53l283 315 14 work work NN cord-333672-ef53l283 315 15 and and CC cord-333672-ef53l283 315 16 overall overall JJ cord-333672-ef53l283 315 17 and and CC cord-333672-ef53l283 315 18 cause cause NN cord-333672-ef53l283 315 19 - - HYPH cord-333672-ef53l283 315 20 specific specific JJ cord-333672-ef53l283 315 21 mortality mortality NN cord-333672-ef53l283 315 22 in in IN cord-333672-ef53l283 315 23 the the DT cord-333672-ef53l283 315 24 danish danish JJ cord-333672-ef53l283 315 25 nurse nurse NN cord-333672-ef53l283 315 26 cohort cohort NN cord-333672-ef53l283 315 27 . . . cord-333672-ef53l283 316 1 Scand Scand NNP cord-333672-ef53l283 316 2 J J NNP cord-333672-ef53l283 316 3 Work Work NNP cord-333672-ef53l283 316 4 Environ Environ NNP cord-333672-ef53l283 316 5 Health Health NNP cord-333672-ef53l283 316 6 Mechanisms Mechanisms NNPS cord-333672-ef53l283 316 7 linking link VBG cord-333672-ef53l283 316 8 circadian circadian NN cord-333672-ef53l283 316 9 clocks clock NNS cord-333672-ef53l283 316 10 , , , cord-333672-ef53l283 316 11 sleep sleep NN cord-333672-ef53l283 316 12 , , , cord-333672-ef53l283 316 13 and and CC cord-333672-ef53l283 316 14 neurodegeneration neurodegeneration NN cord-333672-ef53l283 317 1 When when WRB cord-333672-ef53l283 317 2 health health NN cord-333672-ef53l283 317 3 professionals professional NNS cord-333672-ef53l283 317 4 look look VBP cord-333672-ef53l283 317 5 death death NN cord-333672-ef53l283 317 6 in in IN cord-333672-ef53l283 317 7 the the DT cord-333672-ef53l283 317 8 eye eye NN cord-333672-ef53l283 317 9 : : : cord-333672-ef53l283 317 10 the the DT cord-333672-ef53l283 317 11 mental mental JJ cord-333672-ef53l283 317 12 health health NN cord-333672-ef53l283 317 13 of of IN cord-333672-ef53l283 317 14 professionals professional NNS cord-333672-ef53l283 317 15 who who WP cord-333672-ef53l283 317 16 deal deal VBP cord-333672-ef53l283 317 17 daily daily RB cord-333672-ef53l283 317 18 with with IN cord-333672-ef53l283 317 19 the the DT cord-333672-ef53l283 317 20 2019 2019 CD cord-333672-ef53l283 317 21 coronavirus coronavirus NN cord-333672-ef53l283 317 22 outbreak outbreak NN cord-333672-ef53l283 317 23 Presenting present VBG cord-333672-ef53l283 317 24 characteristics characteristic NNS cord-333672-ef53l283 317 25 , , , cord-333672-ef53l283 317 26 comorbidities comorbiditie NNS cord-333672-ef53l283 317 27 , , , cord-333672-ef53l283 317 28 and and CC cord-333672-ef53l283 317 29 outcomes outcome NNS cord-333672-ef53l283 317 30 among among IN cord-333672-ef53l283 317 31 5700 5700 CD cord-333672-ef53l283 317 32 patients patient NNS cord-333672-ef53l283 317 33 hospitalized hospitalize VBN cord-333672-ef53l283 317 34 with with IN cord-333672-ef53l283 317 35 COVID-19 COVID-19 NNP cord-333672-ef53l283 317 36 in in IN cord-333672-ef53l283 317 37 the the DT cord-333672-ef53l283 317 38 New New NNP cord-333672-ef53l283 317 39 York York NNP cord-333672-ef53l283 317 40 city city NN cord-333672-ef53l283 317 41 area area NN cord-333672-ef53l283 317 42 ONS ONS NNP cord-333672-ef53l283 317 43 . . . cord-333672-ef53l283 318 1 Deaths death NNS cord-333672-ef53l283 318 2 Involving involve VBG cord-333672-ef53l283 318 3 COVID-19 COVID-19 NNP cord-333672-ef53l283 318 4 , , , cord-333672-ef53l283 318 5 England England NNP cord-333672-ef53l283 318 6 and and CC cord-333672-ef53l283 318 7 Wales Wales NNP cord-333672-ef53l283 318 8 : : : cord-333672-ef53l283 319 1 Deaths death NNS cord-333672-ef53l283 319 2 Occurring occur VBG cord-333672-ef53l283 319 3 in in IN cord-333672-ef53l283 319 4 Middle Middle NNP cord-333672-ef53l283 319 5 east east NNP cord-333672-ef53l283 319 6 respiratory respiratory JJ cord-333672-ef53l283 319 7 syndrome syndrome NN cord-333672-ef53l283 319 8 coronavirus coronavirus NN cord-333672-ef53l283 319 9 : : : cord-333672-ef53l283 319 10 risk risk NN cord-333672-ef53l283 319 11 factors factor NNS cord-333672-ef53l283 319 12 and and CC cord-333672-ef53l283 319 13 determinants determinant NNS cord-333672-ef53l283 319 14 of of IN cord-333672-ef53l283 319 15 primary primary JJ cord-333672-ef53l283 319 16 , , , cord-333672-ef53l283 319 17 household household NN cord-333672-ef53l283 319 18 , , , cord-333672-ef53l283 319 19 and and CC cord-333672-ef53l283 319 20 nosocomial nosocomial JJ cord-333672-ef53l283 319 21 transmission transmission NN cord-333672-ef53l283 319 22 Clinical clinical JJ cord-333672-ef53l283 319 23 determinants determinant NNS cord-333672-ef53l283 319 24 of of IN cord-333672-ef53l283 319 25 the the DT cord-333672-ef53l283 319 26 severity severity NN cord-333672-ef53l283 319 27 of of IN cord-333672-ef53l283 319 28 middle middle NNP cord-333672-ef53l283 319 29 east east NNP cord-333672-ef53l283 319 30 respiratory respiratory JJ cord-333672-ef53l283 319 31 syndrome syndrome NN cord-333672-ef53l283 319 32 ( ( -LRB- cord-333672-ef53l283 319 33 MERS MERS NNP cord-333672-ef53l283 319 34 ) ) -RRB- cord-333672-ef53l283 319 35 : : : cord-333672-ef53l283 319 36 a a DT cord-333672-ef53l283 319 37 systematic systematic JJ cord-333672-ef53l283 319 38 review review NN cord-333672-ef53l283 319 39 and and CC cord-333672-ef53l283 319 40 meta meta NNP cord-333672-ef53l283 319 41 - - HYPH cord-333672-ef53l283 319 42 analysis analysis NN cord-333672-ef53l283 319 43 Short Short NNP cord-333672-ef53l283 319 44 term term NN cord-333672-ef53l283 319 45 outcome outcome NN cord-333672-ef53l283 319 46 and and CC cord-333672-ef53l283 319 47 risk risk NN cord-333672-ef53l283 319 48 factors factor NNS cord-333672-ef53l283 319 49 for for IN cord-333672-ef53l283 319 50 adverse adverse JJ cord-333672-ef53l283 319 51 clinical clinical JJ cord-333672-ef53l283 319 52 outcomes outcome NNS cord-333672-ef53l283 319 53 in in IN cord-333672-ef53l283 319 54 adults adult NNS cord-333672-ef53l283 319 55 with with IN cord-333672-ef53l283 319 56 severe severe JJ cord-333672-ef53l283 319 57 acute acute JJ cord-333672-ef53l283 319 58 respiratory respiratory JJ cord-333672-ef53l283 319 59 syndrome syndrome NN cord-333672-ef53l283 319 60 ( ( -LRB- cord-333672-ef53l283 319 61 SARS SARS NNP cord-333672-ef53l283 319 62 ) ) -RRB- cord-333672-ef53l283 320 1 Severe severe JJ cord-333672-ef53l283 320 2 acute acute JJ cord-333672-ef53l283 320 3 respiratory respiratory JJ cord-333672-ef53l283 320 4 syndrome syndrome NN cord-333672-ef53l283 320 5 : : : cord-333672-ef53l283 320 6 clinical clinical JJ cord-333672-ef53l283 320 7 and and CC cord-333672-ef53l283 320 8 laboratory laboratory NN cord-333672-ef53l283 320 9 manifestations manifestation NNS cord-333672-ef53l283 321 1 A a DT cord-333672-ef53l283 321 2 novel novel JJ cord-333672-ef53l283 321 3 risk risk NN cord-333672-ef53l283 321 4 factor factor NN cord-333672-ef53l283 321 5 for for IN cord-333672-ef53l283 321 6 a a DT cord-333672-ef53l283 321 7 novel novel JJ cord-333672-ef53l283 321 8 virus virus NN cord-333672-ef53l283 321 9 : : : cord-333672-ef53l283 321 10 obesity obesity NN cord-333672-ef53l283 321 11 and and CC cord-333672-ef53l283 321 12 2009 2009 CD cord-333672-ef53l283 321 13 pandemic pandemic NN cord-333672-ef53l283 321 14 influenza influenza NN cord-333672-ef53l283 321 15 A A NNP cord-333672-ef53l283 321 16 ( ( -LRB- cord-333672-ef53l283 321 17 H1N1 H1N1 NNP cord-333672-ef53l283 321 18 ) ) -RRB- cord-333672-ef53l283 322 1 H1N1 H1N1 NNP cord-333672-ef53l283 322 2 influenza influenza NN cord-333672-ef53l283 322 3 A A NNP cord-333672-ef53l283 322 4 in in IN cord-333672-ef53l283 322 5 a a DT cord-333672-ef53l283 322 6 hospital hospital NN cord-333672-ef53l283 322 7 in in IN cord-333672-ef53l283 322 8 Norway Norway NNP cord-333672-ef53l283 323 1 Working Working NNP cord-333672-ef53l283 323 2 time time NN cord-333672-ef53l283 323 3 society society NN cord-333672-ef53l283 323 4 consensus consensus NN cord-333672-ef53l283 323 5 statements statement NNS cord-333672-ef53l283 323 6 : : : cord-333672-ef53l283 323 7 individual individual JJ cord-333672-ef53l283 323 8 differences difference NNS cord-333672-ef53l283 323 9 in in IN cord-333672-ef53l283 323 10 shift shift NN cord-333672-ef53l283 323 11 work work NN cord-333672-ef53l283 323 12 tolerance tolerance NN cord-333672-ef53l283 323 13 and and CC cord-333672-ef53l283 323 14 recommendations recommendation NNS cord-333672-ef53l283 323 15 for for IN cord-333672-ef53l283 323 16 research research NN cord-333672-ef53l283 323 17 and and CC cord-333672-ef53l283 323 18 practice practice VB cord-333672-ef53l283 323 19 Circadian circadian JJ cord-333672-ef53l283 323 20 disruption disruption NN cord-333672-ef53l283 324 1 : : : cord-333672-ef53l283 324 2 what what WP cord-333672-ef53l283 324 3 do do VBP cord-333672-ef53l283 324 4 we -PRON- PRP cord-333672-ef53l283 324 5 actually actually RB cord-333672-ef53l283 324 6 mean mean VB cord-333672-ef53l283 324 7 ? ? . cord-333672-ef53l283 325 1 Epidemiology epidemiology NN cord-333672-ef53l283 325 2 of of IN cord-333672-ef53l283 325 3 the the DT cord-333672-ef53l283 325 4 human human JJ cord-333672-ef53l283 325 5 circadian circadian NN cord-333672-ef53l283 325 6 clock clock NN cord-333672-ef53l283 325 7 Mismatch mismatch NN cord-333672-ef53l283 325 8 of of IN cord-333672-ef53l283 325 9 sleep sleep NN cord-333672-ef53l283 325 10 and and CC cord-333672-ef53l283 325 11 work work VB cord-333672-ef53l283 325 12 timing timing NN cord-333672-ef53l283 325 13 and and CC cord-333672-ef53l283 325 14 risk risk NN cord-333672-ef53l283 325 15 of of IN cord-333672-ef53l283 325 16 type type NN cord-333672-ef53l283 325 17 2 2 CD cord-333672-ef53l283 325 18 diabetes diabetes NN cord-333672-ef53l283 325 19 Shift shift JJ cord-333672-ef53l283 325 20 work work NN cord-333672-ef53l283 325 21 patterns pattern NNS cord-333672-ef53l283 325 22 , , , cord-333672-ef53l283 325 23 chronotype chronotype NN cord-333672-ef53l283 325 24 , , , cord-333672-ef53l283 325 25 and and CC cord-333672-ef53l283 325 26 epithelial epithelial JJ cord-333672-ef53l283 325 27 ovarian ovarian JJ cord-333672-ef53l283 325 28 cancer cancer NN cord-333672-ef53l283 325 29 risk risk NN cord-333672-ef53l283 325 30 Sleep Sleep NNP cord-333672-ef53l283 325 31 and and CC cord-333672-ef53l283 325 32 need need VB cord-333672-ef53l283 325 33 for for IN cord-333672-ef53l283 325 34 recovery recovery NN cord-333672-ef53l283 325 35 in in IN cord-333672-ef53l283 325 36 shift shift NN cord-333672-ef53l283 325 37 workers worker NNS cord-333672-ef53l283 325 38 : : : cord-333672-ef53l283 325 39 do do VB cord-333672-ef53l283 325 40 chronotype chronotype NN cord-333672-ef53l283 325 41 and and CC cord-333672-ef53l283 325 42 age age NN cord-333672-ef53l283 325 43 matter matter NN cord-333672-ef53l283 325 44 Shift shift VB cord-333672-ef53l283 325 45 work work NN cord-333672-ef53l283 325 46 , , , cord-333672-ef53l283 325 47 chronotype chronotype NN cord-333672-ef53l283 325 48 , , , cord-333672-ef53l283 325 49 and and CC cord-333672-ef53l283 325 50 melatonin melatonin NN cord-333672-ef53l283 325 51 rhythm rhythm NN cord-333672-ef53l283 325 52 in in IN cord-333672-ef53l283 325 53 nurses nurse NNS cord-333672-ef53l283 326 1 The the DT cord-333672-ef53l283 326 2 circadian circadian NN cord-333672-ef53l283 326 3 clock clock NN cord-333672-ef53l283 326 4 and and CC cord-333672-ef53l283 326 5 human human JJ cord-333672-ef53l283 326 6 health health NN cord-333672-ef53l283 326 7 Sleep sleep NN cord-333672-ef53l283 326 8 , , , cord-333672-ef53l283 326 9 health health NN cord-333672-ef53l283 326 10 , , , cord-333672-ef53l283 326 11 and and CC cord-333672-ef53l283 326 12 society society NN cord-333672-ef53l283 326 13 Stability stability NN cord-333672-ef53l283 326 14 , , , cord-333672-ef53l283 326 15 precision precision NN cord-333672-ef53l283 326 16 , , , cord-333672-ef53l283 326 17 and and CC cord-333672-ef53l283 326 18 near-24-hour near-24-hour NNP cord-333672-ef53l283 326 19 period period NN cord-333672-ef53l283 326 20 of of IN cord-333672-ef53l283 326 21 the the DT cord-333672-ef53l283 326 22 human human JJ cord-333672-ef53l283 326 23 circadian circadian NN cord-333672-ef53l283 326 24 pacemaker pacemaker NN cord-333672-ef53l283 326 25 Physiology Physiology NNP cord-333672-ef53l283 326 26 of of IN cord-333672-ef53l283 326 27 circadian circadian NN cord-333672-ef53l283 326 28 entrainment entrainment NN cord-333672-ef53l283 326 29 Effect effect NN cord-333672-ef53l283 326 30 of of IN cord-333672-ef53l283 326 31 light light JJ cord-333672-ef53l283 326 32 wavelength wavelength NN cord-333672-ef53l283 326 33 on on IN cord-333672-ef53l283 326 34 suppression suppression NN cord-333672-ef53l283 326 35 and and CC cord-333672-ef53l283 326 36 phase phase NN cord-333672-ef53l283 326 37 delay delay NN cord-333672-ef53l283 326 38 of of IN cord-333672-ef53l283 326 39 the the DT cord-333672-ef53l283 326 40 melatonin melatonin NN cord-333672-ef53l283 326 41 rhythm rhythm NN cord-333672-ef53l283 326 42 Health Health NNP cord-333672-ef53l283 326 43 - - HYPH cord-333672-ef53l283 326 44 related relate VBN cord-333672-ef53l283 326 45 interventions intervention NNS cord-333672-ef53l283 326 46 among among IN cord-333672-ef53l283 326 47 night night NN cord-333672-ef53l283 326 48 shift shift NN cord-333672-ef53l283 326 49 workers worker NNS cord-333672-ef53l283 326 50 : : : cord-333672-ef53l283 326 51 a a DT cord-333672-ef53l283 326 52 critical critical JJ cord-333672-ef53l283 326 53 review review NN cord-333672-ef53l283 326 54 of of IN cord-333672-ef53l283 326 55 the the DT cord-333672-ef53l283 326 56 literature literature NN cord-333672-ef53l283 326 57 High high JJ cord-333672-ef53l283 326 58 sensitivity sensitivity NN cord-333672-ef53l283 326 59 and and CC cord-333672-ef53l283 326 60 interindividual interindividual JJ cord-333672-ef53l283 326 61 variability variability NN cord-333672-ef53l283 326 62 in in IN cord-333672-ef53l283 326 63 the the DT cord-333672-ef53l283 326 64 response response NN cord-333672-ef53l283 326 65 of of IN cord-333672-ef53l283 326 66 the the DT cord-333672-ef53l283 326 67 human human JJ cord-333672-ef53l283 326 68 circadian circadian NN cord-333672-ef53l283 326 69 system system NN cord-333672-ef53l283 326 70 to to IN cord-333672-ef53l283 326 71 evening evening NN cord-333672-ef53l283 326 72 light light JJ cord-333672-ef53l283 326 73 Physiology physiology NN cord-333672-ef53l283 326 74 and and CC cord-333672-ef53l283 326 75 pharmacology pharmacology NN cord-333672-ef53l283 326 76 of of IN cord-333672-ef53l283 326 77 melatonin melatonin NN cord-333672-ef53l283 326 78 in in IN cord-333672-ef53l283 326 79 relation relation NN cord-333672-ef53l283 326 80 to to IN cord-333672-ef53l283 326 81 biological biological JJ cord-333672-ef53l283 326 82 rhythms rhythm NNS cord-333672-ef53l283 326 83 Evening evening NN cord-333672-ef53l283 326 84 melatonin melatonin NN cord-333672-ef53l283 326 85 and and CC cord-333672-ef53l283 326 86 bright bright JJ cord-333672-ef53l283 326 87 light light JJ cord-333672-ef53l283 326 88 administration administration NN cord-333672-ef53l283 326 89 induce induce VB cord-333672-ef53l283 326 90 additive additive NN cord-333672-ef53l283 326 91 phase phase NN cord-333672-ef53l283 326 92 shifts shift NNS cord-333672-ef53l283 326 93 in in IN cord-333672-ef53l283 326 94 dim dim JJ cord-333672-ef53l283 326 95 light light JJ cord-333672-ef53l283 326 96 melatonin melatonin NN cord-333672-ef53l283 326 97 onset onset NN cord-333672-ef53l283 326 98 Phase phase NN cord-333672-ef53l283 326 99 - - HYPH cord-333672-ef53l283 326 100 shifting shift VBG cord-333672-ef53l283 326 101 human human JJ cord-333672-ef53l283 326 102 circadian circadian NN cord-333672-ef53l283 326 103 rhythms rhythm NNS cord-333672-ef53l283 326 104 with with IN cord-333672-ef53l283 326 105 exercise exercise NN cord-333672-ef53l283 326 106 during during IN cord-333672-ef53l283 326 107 the the DT cord-333672-ef53l283 326 108 night night NN cord-333672-ef53l283 326 109 shift shift NN cord-333672-ef53l283 326 110 Human human JJ cord-333672-ef53l283 326 111 circadian circadian NN cord-333672-ef53l283 326 112 phase phase NN cord-333672-ef53l283 326 113 - - HYPH cord-333672-ef53l283 326 114 response response NN cord-333672-ef53l283 326 115 curves curve NNS cord-333672-ef53l283 326 116 for for IN cord-333672-ef53l283 326 117 exercise exercise NN cord-333672-ef53l283 326 118 Circadian circadian NN cord-333672-ef53l283 326 119 phase phase NN cord-333672-ef53l283 326 120 - - HYPH cord-333672-ef53l283 326 121 shifting shift VBG cord-333672-ef53l283 326 122 effects effect NNS cord-333672-ef53l283 326 123 of of IN cord-333672-ef53l283 326 124 bright bright JJ cord-333672-ef53l283 326 125 light light NN cord-333672-ef53l283 326 126 , , , cord-333672-ef53l283 326 127 exercise exercise NN cord-333672-ef53l283 326 128 , , , cord-333672-ef53l283 326 129 and and CC cord-333672-ef53l283 326 130 bright bright JJ cord-333672-ef53l283 326 131 light light NN cord-333672-ef53l283 326 132 + + CC cord-333672-ef53l283 326 133 exercise exercise NN cord-333672-ef53l283 326 134 A a DT cord-333672-ef53l283 326 135 Behavioristic Behavioristic NNP cord-333672-ef53l283 326 136 Study Study NNP cord-333672-ef53l283 326 137 of of IN cord-333672-ef53l283 326 138 the the DT cord-333672-ef53l283 326 139 Activity activity NN cord-333672-ef53l283 326 140 of of IN cord-333672-ef53l283 326 141 the the DT cord-333672-ef53l283 326 142 Rat rat NN cord-333672-ef53l283 327 1 Restricted restrict VBN cord-333672-ef53l283 327 2 feeding feed VBG cord-333672-ef53l283 327 3 uncouples uncouple NNS cord-333672-ef53l283 327 4 circadian circadian NN cord-333672-ef53l283 327 5 oscillators oscillator NNS cord-333672-ef53l283 327 6 in in IN cord-333672-ef53l283 327 7 peripheral peripheral JJ cord-333672-ef53l283 327 8 tissues tissue NNS cord-333672-ef53l283 327 9 from from IN cord-333672-ef53l283 327 10 the the DT cord-333672-ef53l283 327 11 central central JJ cord-333672-ef53l283 327 12 pacemaker pacemaker NN cord-333672-ef53l283 327 13 in in IN cord-333672-ef53l283 327 14 the the DT cord-333672-ef53l283 327 15 suprachiasmatic suprachiasmatic NN cord-333672-ef53l283 327 16 nucleus nucleus NN cord-333672-ef53l283 328 1 Meal meal NN cord-333672-ef53l283 328 2 timing timing NN cord-333672-ef53l283 328 3 regulates regulate VBZ cord-333672-ef53l283 328 4 the the DT cord-333672-ef53l283 328 5 human human JJ cord-333672-ef53l283 328 6 circadian circadian NN cord-333672-ef53l283 328 7 system system NN cord-333672-ef53l283 328 8 Food Food NNP cord-333672-ef53l283 328 9 as as IN cord-333672-ef53l283 328 10 a a DT cord-333672-ef53l283 328 11 circadian circadian NN cord-333672-ef53l283 328 12 time time NN cord-333672-ef53l283 328 13 cue cue NN cord-333672-ef53l283 328 14 -evidence -evidence NN cord-333672-ef53l283 328 15 from from IN cord-333672-ef53l283 328 16 human human JJ cord-333672-ef53l283 328 17 studies study NNS cord-333672-ef53l283 328 18 Phase phase NN cord-333672-ef53l283 328 19 - - HYPH cord-333672-ef53l283 328 20 shifting shift VBG cord-333672-ef53l283 328 21 human human JJ cord-333672-ef53l283 328 22 circadian circadian NN cord-333672-ef53l283 328 23 rhythms rhythm NNS cord-333672-ef53l283 328 24 : : : cord-333672-ef53l283 328 25 influence influence NN cord-333672-ef53l283 328 26 of of IN cord-333672-ef53l283 328 27 sleep sleep NN cord-333672-ef53l283 328 28 timing timing NN cord-333672-ef53l283 328 29 , , , cord-333672-ef53l283 328 30 social social JJ cord-333672-ef53l283 328 31 contact contact NN cord-333672-ef53l283 328 32 and and CC cord-333672-ef53l283 328 33 light light NN cord-333672-ef53l283 328 34 exposure exposure NN cord-333672-ef53l283 329 1 The the DT cord-333672-ef53l283 329 2 factors factor NNS cord-333672-ef53l283 329 3 influencing influence VBG cord-333672-ef53l283 329 4 the the DT cord-333672-ef53l283 329 5 eating eat VBG cord-333672-ef53l283 329 6 behaviour behaviour NN cord-333672-ef53l283 329 7 of of IN cord-333672-ef53l283 329 8 shiftworkers shiftworkers NNP cord-333672-ef53l283 329 9 : : : cord-333672-ef53l283 329 10 what what WP cord-333672-ef53l283 329 11 , , , cord-333672-ef53l283 329 12 when when WRB cord-333672-ef53l283 329 13 , , , cord-333672-ef53l283 329 14 where where WRB cord-333672-ef53l283 329 15 and and CC cord-333672-ef53l283 329 16 why why WRB cord-333672-ef53l283 329 17 Protein protein NN cord-333672-ef53l283 329 18 " " '' cord-333672-ef53l283 329 19 requirements requirement NNS cord-333672-ef53l283 329 20 " " '' cord-333672-ef53l283 329 21 beyond beyond IN cord-333672-ef53l283 329 22 the the DT cord-333672-ef53l283 329 23 RDA RDA NNP cord-333672-ef53l283 329 24 : : : cord-333672-ef53l283 329 25 implications implication NNS cord-333672-ef53l283 329 26 for for IN cord-333672-ef53l283 329 27 optimizing optimize VBG cord-333672-ef53l283 329 28 health health NN cord-333672-ef53l283 329 29 A a DT cord-333672-ef53l283 329 30 review review NN cord-333672-ef53l283 329 31 of of IN cord-333672-ef53l283 329 32 caffeine caffeine NN cord-333672-ef53l283 329 33 's 's POS cord-333672-ef53l283 329 34 effects effect NNS cord-333672-ef53l283 329 35 on on IN cord-333672-ef53l283 329 36 cognitive cognitive JJ cord-333672-ef53l283 329 37 , , , cord-333672-ef53l283 329 38 physical physical JJ cord-333672-ef53l283 329 39 and and CC cord-333672-ef53l283 329 40 occupational occupational JJ cord-333672-ef53l283 329 41 performance performance NN cord-333672-ef53l283 329 42 Multiple multiple JJ cord-333672-ef53l283 329 43 dose dose NN cord-333672-ef53l283 329 44 pharmacokinetics pharmacokinetic NNS cord-333672-ef53l283 329 45 of of IN cord-333672-ef53l283 329 46 caffeine caffeine NN cord-333672-ef53l283 329 47 administered administer VBN cord-333672-ef53l283 329 48 in in IN cord-333672-ef53l283 329 49 chewing chew VBG cord-333672-ef53l283 329 50 gum gum NN cord-333672-ef53l283 329 51 to to IN cord-333672-ef53l283 329 52 normal normal JJ cord-333672-ef53l283 329 53 healthy healthy JJ cord-333672-ef53l283 329 54 volunteers volunteer NNS cord-333672-ef53l283 330 1 The the DT cord-333672-ef53l283 330 2 rate rate NN cord-333672-ef53l283 330 3 of of IN cord-333672-ef53l283 330 4 absorption absorption NN cord-333672-ef53l283 330 5 and and CC cord-333672-ef53l283 330 6 relative relative JJ cord-333672-ef53l283 330 7 bioavailability bioavailability NN cord-333672-ef53l283 330 8 of of IN cord-333672-ef53l283 330 9 caffeine caffeine NN cord-333672-ef53l283 330 10 administered administer VBN cord-333672-ef53l283 330 11 in in IN cord-333672-ef53l283 330 12 chewing chew VBG cord-333672-ef53l283 330 13 gum gum NN cord-333672-ef53l283 330 14 versus versus IN cord-333672-ef53l283 330 15 capsules capsule NNS cord-333672-ef53l283 330 16 to to IN cord-333672-ef53l283 330 17 normal normal JJ cord-333672-ef53l283 330 18 healthy healthy JJ cord-333672-ef53l283 330 19 volunteers volunteer NNS cord-333672-ef53l283 331 1 Caffeine caffeine NN cord-333672-ef53l283 331 2 effects effect NNS cord-333672-ef53l283 331 3 on on IN cord-333672-ef53l283 331 4 sleep sleep NN cord-333672-ef53l283 331 5 taken take VBN cord-333672-ef53l283 331 6 0 0 CD cord-333672-ef53l283 331 7 , , , cord-333672-ef53l283 331 8 3 3 CD cord-333672-ef53l283 331 9 , , , cord-333672-ef53l283 331 10 or or CC cord-333672-ef53l283 331 11 6 6 CD cord-333672-ef53l283 331 12 hours hour NNS cord-333672-ef53l283 331 13 before before IN cord-333672-ef53l283 331 14 going go VBG cord-333672-ef53l283 331 15 to to IN cord-333672-ef53l283 331 16 bed bed NN cord-333672-ef53l283 332 1 Time time NN cord-333672-ef53l283 332 2 - - HYPH cord-333672-ef53l283 332 3 fixed fix VBN cord-333672-ef53l283 332 4 feeding feeding NN cord-333672-ef53l283 332 5 prevents prevent VBZ cord-333672-ef53l283 332 6 obesity obesity NN cord-333672-ef53l283 332 7 induced induce VBN cord-333672-ef53l283 332 8 by by IN cord-333672-ef53l283 332 9 chronic chronic JJ cord-333672-ef53l283 332 10 advances advance NNS cord-333672-ef53l283 332 11 of of IN cord-333672-ef53l283 332 12 light light JJ cord-333672-ef53l283 332 13 / / SYM cord-333672-ef53l283 332 14 dark dark JJ cord-333672-ef53l283 332 15 cycles cycle NNS cord-333672-ef53l283 332 16 in in IN cord-333672-ef53l283 332 17 mouse mouse NN cord-333672-ef53l283 332 18 models model NNS cord-333672-ef53l283 332 19 of of IN cord-333672-ef53l283 332 20 jet jet NN cord-333672-ef53l283 332 21 - - HYPH cord-333672-ef53l283 332 22 lag lag NN cord-333672-ef53l283 332 23 / / SYM cord-333672-ef53l283 332 24 shift shift NN cord-333672-ef53l283 332 25 work work NN cord-333672-ef53l283 332 26 Time time NN cord-333672-ef53l283 332 27 - - HYPH cord-333672-ef53l283 332 28 restricted restrict VBN cord-333672-ef53l283 332 29 feeding feeding NN cord-333672-ef53l283 332 30 improves improve VBZ cord-333672-ef53l283 332 31 adaptation adaptation NN cord-333672-ef53l283 332 32 to to IN cord-333672-ef53l283 332 33 chronically chronically RB cord-333672-ef53l283 332 34 alternating alternate VBG cord-333672-ef53l283 332 35 light light JJ cord-333672-ef53l283 332 36 - - HYPH cord-333672-ef53l283 332 37 dark dark JJ cord-333672-ef53l283 332 38 cycles cycle NNS cord-333672-ef53l283 332 39 Timing timing NN cord-333672-ef53l283 332 40 of of IN cord-333672-ef53l283 332 41 food food NN cord-333672-ef53l283 332 42 intake intake NN cord-333672-ef53l283 332 43 during during IN cord-333672-ef53l283 332 44 simulated simulated JJ cord-333672-ef53l283 332 45 night night NN cord-333672-ef53l283 332 46 shift shift NN cord-333672-ef53l283 332 47 impacts impact NNS cord-333672-ef53l283 332 48 glucose glucose NN cord-333672-ef53l283 332 49 metabolism metabolism NN cord-333672-ef53l283 332 50 : : : cord-333672-ef53l283 332 51 a a DT cord-333672-ef53l283 332 52 controlled control VBN cord-333672-ef53l283 332 53 study study NN cord-333672-ef53l283 333 1 The the DT cord-333672-ef53l283 333 2 impact impact NN cord-333672-ef53l283 333 3 of of IN cord-333672-ef53l283 333 4 meal meal NN cord-333672-ef53l283 333 5 timing timing NN cord-333672-ef53l283 333 6 on on IN cord-333672-ef53l283 333 7 performance performance NN cord-333672-ef53l283 333 8 , , , cord-333672-ef53l283 333 9 sleepiness sleepiness NN cord-333672-ef53l283 333 10 , , , cord-333672-ef53l283 333 11 gastric gastric JJ cord-333672-ef53l283 333 12 upset upset JJ cord-333672-ef53l283 333 13 , , , cord-333672-ef53l283 333 14 and and CC cord-333672-ef53l283 333 15 hunger hunger NN cord-333672-ef53l283 333 16 during during IN cord-333672-ef53l283 333 17 simulated simulated JJ cord-333672-ef53l283 333 18 night night NN cord-333672-ef53l283 333 19 shift shift NN cord-333672-ef53l283 333 20 . . . cord-333672-ef53l283 334 1 Ind Ind NNP cord-333672-ef53l283 334 2 Health Health NNP cord-333672-ef53l283 334 3 Dietary dietary JJ cord-333672-ef53l283 334 4 patterns pattern NNS cord-333672-ef53l283 334 5 of of IN cord-333672-ef53l283 334 6 nurses nurse NNS cord-333672-ef53l283 334 7 on on IN cord-333672-ef53l283 334 8 rotational rotational JJ cord-333672-ef53l283 334 9 shifts shift NNS cord-333672-ef53l283 334 10 are be VBP cord-333672-ef53l283 334 11 marked mark VBN cord-333672-ef53l283 334 12 by by IN cord-333672-ef53l283 334 13 redistribution redistribution NN cord-333672-ef53l283 334 14 of of IN cord-333672-ef53l283 334 15 energy energy NN cord-333672-ef53l283 334 16 into into IN cord-333672-ef53l283 334 17 the the DT cord-333672-ef53l283 334 18 nightshift nightshift NN cord-333672-ef53l283 334 19 Meta Meta NNP cord-333672-ef53l283 334 20 - - HYPH cord-333672-ef53l283 334 21 analysis analysis NN cord-333672-ef53l283 334 22 of of IN cord-333672-ef53l283 334 23 relation relation NN cord-333672-ef53l283 334 24 of of IN cord-333672-ef53l283 334 25 skipping skip VBG cord-333672-ef53l283 334 26 breakfast breakfast NN cord-333672-ef53l283 334 27 with with IN cord-333672-ef53l283 334 28 heart heart NN cord-333672-ef53l283 334 29 disease disease NN cord-333672-ef53l283 334 30 Breakfast Breakfast NNP cord-333672-ef53l283 334 31 skipping skipping NN cord-333672-ef53l283 334 32 is be VBZ cord-333672-ef53l283 334 33 associated associate VBN cord-333672-ef53l283 334 34 with with IN cord-333672-ef53l283 334 35 increased increase VBN cord-333672-ef53l283 334 36 risk risk NN cord-333672-ef53l283 334 37 of of IN cord-333672-ef53l283 334 38 type type NN cord-333672-ef53l283 334 39 2 2 CD cord-333672-ef53l283 334 40 diabetes diabete NNS cord-333672-ef53l283 334 41 among among IN cord-333672-ef53l283 334 42 adults adult NNS cord-333672-ef53l283 334 43 : : : cord-333672-ef53l283 335 1 a a DT cord-333672-ef53l283 335 2 systematic systematic JJ cord-333672-ef53l283 335 3 review review NN cord-333672-ef53l283 335 4 and and CC cord-333672-ef53l283 335 5 meta meta NNP cord-333672-ef53l283 335 6 - - HYPH cord-333672-ef53l283 335 7 analysis analysis NN cord-333672-ef53l283 335 8 of of IN cord-333672-ef53l283 335 9 prospective prospective JJ cord-333672-ef53l283 335 10 cohort cohort NN cord-333672-ef53l283 335 11 studies study NNS cord-333672-ef53l283 335 12 Is be VBZ cord-333672-ef53l283 335 13 breakfast breakfast NN cord-333672-ef53l283 335 14 the the DT cord-333672-ef53l283 335 15 most most RBS cord-333672-ef53l283 335 16 important important JJ cord-333672-ef53l283 335 17 meal meal NN cord-333672-ef53l283 335 18 of of IN cord-333672-ef53l283 335 19 the the DT cord-333672-ef53l283 335 20 day day NN cord-333672-ef53l283 335 21 ? ? . cord-333672-ef53l283 336 1 The the DT cord-333672-ef53l283 336 2 causal causal JJ cord-333672-ef53l283 336 3 role role NN cord-333672-ef53l283 336 4 of of IN cord-333672-ef53l283 336 5 breakfast breakfast NN cord-333672-ef53l283 336 6 in in IN cord-333672-ef53l283 336 7 energy energy NN cord-333672-ef53l283 336 8 balance balance NN cord-333672-ef53l283 336 9 and and CC cord-333672-ef53l283 336 10 health health NN cord-333672-ef53l283 336 11 : : : cord-333672-ef53l283 336 12 a a DT cord-333672-ef53l283 336 13 randomized randomized JJ cord-333672-ef53l283 336 14 controlled control VBN cord-333672-ef53l283 336 15 trial trial NN cord-333672-ef53l283 336 16 in in IN cord-333672-ef53l283 336 17 lean lean JJ cord-333672-ef53l283 336 18 adults adult NNS cord-333672-ef53l283 337 1 The the DT cord-333672-ef53l283 337 2 causal causal JJ cord-333672-ef53l283 337 3 role role NN cord-333672-ef53l283 337 4 of of IN cord-333672-ef53l283 337 5 breakfast breakfast NN cord-333672-ef53l283 337 6 in in IN cord-333672-ef53l283 337 7 energy energy NN cord-333672-ef53l283 337 8 balance balance NN cord-333672-ef53l283 337 9 and and CC cord-333672-ef53l283 337 10 health health NN cord-333672-ef53l283 337 11 : : : cord-333672-ef53l283 337 12 a a DT cord-333672-ef53l283 337 13 randomized randomized JJ cord-333672-ef53l283 337 14 controlled control VBN cord-333672-ef53l283 337 15 trial trial NN cord-333672-ef53l283 337 16 in in IN cord-333672-ef53l283 337 17 obese obese JJ cord-333672-ef53l283 337 18 adults adult NNS cord-333672-ef53l283 337 19 Early early JJ cord-333672-ef53l283 337 20 time time NN cord-333672-ef53l283 337 21 - - HYPH cord-333672-ef53l283 337 22 restricted restrict VBN cord-333672-ef53l283 337 23 feeding feeding NN cord-333672-ef53l283 337 24 improves improve VBZ cord-333672-ef53l283 337 25 insulin insulin NN cord-333672-ef53l283 337 26 sensitivity sensitivity NN cord-333672-ef53l283 337 27 , , , cord-333672-ef53l283 337 28 blood blood NN cord-333672-ef53l283 337 29 pressure pressure NN cord-333672-ef53l283 337 30 , , , cord-333672-ef53l283 337 31 and and CC cord-333672-ef53l283 337 32 oxidative oxidative JJ cord-333672-ef53l283 337 33 stress stress NN cord-333672-ef53l283 337 34 even even RB cord-333672-ef53l283 337 35 without without IN cord-333672-ef53l283 337 36 weight weight NN cord-333672-ef53l283 337 37 loss loss NN cord-333672-ef53l283 337 38 in in IN cord-333672-ef53l283 337 39 men man NNS cord-333672-ef53l283 337 40 with with IN cord-333672-ef53l283 337 41 prediabetes prediabete NNS cord-333672-ef53l283 338 1 Early early JJ cord-333672-ef53l283 338 2 time time NN cord-333672-ef53l283 338 3 - - HYPH cord-333672-ef53l283 338 4 restricted restrict VBN cord-333672-ef53l283 338 5 feeding feeding NN cord-333672-ef53l283 338 6 improves improve VBZ cord-333672-ef53l283 338 7 24-hour 24-hour JJ cord-333672-ef53l283 338 8 glucose glucose NN cord-333672-ef53l283 338 9 levels level NNS cord-333672-ef53l283 338 10 and and CC cord-333672-ef53l283 338 11 affects affect VBZ cord-333672-ef53l283 338 12 markers marker NNS cord-333672-ef53l283 338 13 of of IN cord-333672-ef53l283 338 14 the the DT cord-333672-ef53l283 338 15 circadian circadian NN cord-333672-ef53l283 338 16 clock clock NN cord-333672-ef53l283 338 17 , , , cord-333672-ef53l283 338 18 aging age VBG cord-333672-ef53l283 338 19 , , , cord-333672-ef53l283 338 20 and and CC cord-333672-ef53l283 338 21 autophagy autophagy NN cord-333672-ef53l283 338 22 in in IN cord-333672-ef53l283 338 23 humans human NNS cord-333672-ef53l283 339 1 Early early RB cord-333672-ef53l283 339 2 timerestricted timerestricted JJ cord-333672-ef53l283 339 3 feeding feeding NN cord-333672-ef53l283 339 4 reduces reduce VBZ cord-333672-ef53l283 339 5 appetite appetite NN cord-333672-ef53l283 339 6 and and CC cord-333672-ef53l283 339 7 increases increase VBZ cord-333672-ef53l283 339 8 fat fat JJ cord-333672-ef53l283 339 9 oxidation oxidation NN cord-333672-ef53l283 339 10 but but CC cord-333672-ef53l283 339 11 does do VBZ cord-333672-ef53l283 339 12 not not RB cord-333672-ef53l283 339 13 affect affect VB cord-333672-ef53l283 339 14 energy energy NN cord-333672-ef53l283 339 15 expenditure expenditure NN cord-333672-ef53l283 339 16 in in IN cord-333672-ef53l283 339 17 humans human NNS cord-333672-ef53l283 339 18 Time time NN cord-333672-ef53l283 339 19 - - HYPH cord-333672-ef53l283 339 20 restricted restrict VBN cord-333672-ef53l283 339 21 feeding feeding NN cord-333672-ef53l283 339 22 improves improve VBZ cord-333672-ef53l283 339 23 glucose glucose NN cord-333672-ef53l283 339 24 tolerance tolerance NN cord-333672-ef53l283 339 25 in in IN cord-333672-ef53l283 339 26 men man NNS cord-333672-ef53l283 339 27 at at IN cord-333672-ef53l283 339 28 risk risk NN cord-333672-ef53l283 339 29 for for IN cord-333672-ef53l283 339 30 type type NN cord-333672-ef53l283 339 31 2 2 CD cord-333672-ef53l283 339 32 diabetes diabetes NN cord-333672-ef53l283 339 33 : : : cord-333672-ef53l283 339 34 a a DT cord-333672-ef53l283 339 35 randomized randomized JJ cord-333672-ef53l283 339 36 crossover crossover NN cord-333672-ef53l283 339 37 trial trial NN cord-333672-ef53l283 340 1 A a DT cord-333672-ef53l283 340 2 pilot pilot NN cord-333672-ef53l283 340 3 feasibility feasibility NN cord-333672-ef53l283 340 4 study study NN cord-333672-ef53l283 340 5 exploring explore VBG cord-333672-ef53l283 340 6 the the DT cord-333672-ef53l283 340 7 effects effect NNS cord-333672-ef53l283 340 8 of of IN cord-333672-ef53l283 340 9 a a DT cord-333672-ef53l283 340 10 moderate moderate JJ cord-333672-ef53l283 340 11 time time NN cord-333672-ef53l283 340 12 - - HYPH cord-333672-ef53l283 340 13 restricted restrict VBN cord-333672-ef53l283 340 14 feeding feeding NN cord-333672-ef53l283 340 15 intervention intervention NN cord-333672-ef53l283 340 16 on on IN cord-333672-ef53l283 340 17 energy energy NN cord-333672-ef53l283 340 18 intake intake NN cord-333672-ef53l283 340 19 , , , cord-333672-ef53l283 340 20 adiposity adiposity NN cord-333672-ef53l283 340 21 and and CC cord-333672-ef53l283 340 22 metabolic metabolic JJ cord-333672-ef53l283 340 23 physiology physiology NN cord-333672-ef53l283 340 24 in in IN cord-333672-ef53l283 340 25 free free RB cord-333672-ef53l283 340 26 - - HYPH cord-333672-ef53l283 340 27 living live VBG cord-333672-ef53l283 340 28 human human JJ cord-333672-ef53l283 340 29 subjects subject NNS cord-333672-ef53l283 341 1 A a DT cord-333672-ef53l283 341 2 delayed delayed JJ cord-333672-ef53l283 341 3 morning morning NN cord-333672-ef53l283 341 4 and and CC cord-333672-ef53l283 341 5 earlier early JJR cord-333672-ef53l283 341 6 evening evening NN cord-333672-ef53l283 341 7 time time NN cord-333672-ef53l283 341 8 - - HYPH cord-333672-ef53l283 341 9 restricted restrict VBN cord-333672-ef53l283 341 10 feeding feeding NN cord-333672-ef53l283 341 11 protocol protocol NN cord-333672-ef53l283 341 12 for for IN cord-333672-ef53l283 341 13 improving improve VBG cord-333672-ef53l283 341 14 glycemic glycemic JJ cord-333672-ef53l283 341 15 control control NN cord-333672-ef53l283 341 16 and and CC cord-333672-ef53l283 341 17 dietary dietary JJ cord-333672-ef53l283 341 18 adherence adherence NN cord-333672-ef53l283 341 19 in in IN cord-333672-ef53l283 341 20 men man NNS cord-333672-ef53l283 341 21 with with IN cord-333672-ef53l283 341 22 overweight overweight JJ cord-333672-ef53l283 341 23 / / SYM cord-333672-ef53l283 341 24 obesity obesity NN cord-333672-ef53l283 341 25 : : : cord-333672-ef53l283 342 1 a a DT cord-333672-ef53l283 342 2 randomized randomized JJ cord-333672-ef53l283 342 3 controlled control VBN cord-333672-ef53l283 342 4 trial trial NN cord-333672-ef53l283 342 5 Ten ten CD cord-333672-ef53l283 342 6 - - HYPH cord-333672-ef53l283 342 7 hour hour NN cord-333672-ef53l283 342 8 time time NN cord-333672-ef53l283 342 9 - - HYPH cord-333672-ef53l283 342 10 restricted restrict VBN cord-333672-ef53l283 342 11 eating eating NN cord-333672-ef53l283 342 12 reduces reduce VBZ cord-333672-ef53l283 342 13 weight weight NN cord-333672-ef53l283 342 14 , , , cord-333672-ef53l283 342 15 blood blood NN cord-333672-ef53l283 342 16 pressure pressure NN cord-333672-ef53l283 342 17 , , , cord-333672-ef53l283 342 18 and and CC cord-333672-ef53l283 342 19 atherogenic atherogenic JJ cord-333672-ef53l283 342 20 lipids lipid NNS cord-333672-ef53l283 342 21 in in IN cord-333672-ef53l283 342 22 patients patient NNS cord-333672-ef53l283 342 23 with with IN cord-333672-ef53l283 342 24 metabolic metabolic JJ cord-333672-ef53l283 342 25 syndrome syndrome NN cord-333672-ef53l283 342 26 Irregular irregular JJ cord-333672-ef53l283 342 27 meal meal NN cord-333672-ef53l283 342 28 - - HYPH cord-333672-ef53l283 342 29 pattern pattern NN cord-333672-ef53l283 342 30 effects effect NNS cord-333672-ef53l283 342 31 on on IN cord-333672-ef53l283 342 32 energy energy NN cord-333672-ef53l283 342 33 expenditure expenditure NN cord-333672-ef53l283 342 34 , , , cord-333672-ef53l283 342 35 metabolism metabolism NN cord-333672-ef53l283 342 36 , , , cord-333672-ef53l283 342 37 and and CC cord-333672-ef53l283 342 38 appetite appetite NN cord-333672-ef53l283 342 39 regulation regulation NN cord-333672-ef53l283 342 40 : : : cord-333672-ef53l283 342 41 a a DT cord-333672-ef53l283 342 42 randomized randomized JJ cord-333672-ef53l283 342 43 controlled control VBN cord-333672-ef53l283 342 44 trial trial NN cord-333672-ef53l283 342 45 in in IN cord-333672-ef53l283 342 46 healthy healthy JJ cord-333672-ef53l283 342 47 normal normal JJ cord-333672-ef53l283 342 48 - - HYPH cord-333672-ef53l283 342 49 weight weight NN cord-333672-ef53l283 342 50 women woman NNS cord-333672-ef53l283 342 51 High high JJ cord-333672-ef53l283 342 52 caloric caloric JJ cord-333672-ef53l283 342 53 intake intake NN cord-333672-ef53l283 342 54 at at IN cord-333672-ef53l283 342 55 breakfast breakfast NN cord-333672-ef53l283 342 56 vs. vs. CC cord-333672-ef53l283 342 57 dinner dinner NN cord-333672-ef53l283 342 58 differentially differentially RB cord-333672-ef53l283 342 59 influences influence VBZ cord-333672-ef53l283 342 60 weight weight NN cord-333672-ef53l283 342 61 loss loss NN cord-333672-ef53l283 342 62 of of IN cord-333672-ef53l283 342 63 overweight overweight JJ cord-333672-ef53l283 342 64 and and CC cord-333672-ef53l283 342 65 obese obese JJ cord-333672-ef53l283 342 66 women woman NNS cord-333672-ef53l283 342 67 Reduction reduction VBP cord-333672-ef53l283 342 68 in in IN cord-333672-ef53l283 342 69 glycated glycated JJ cord-333672-ef53l283 342 70 hemoglobin hemoglobin NN cord-333672-ef53l283 342 71 and and CC cord-333672-ef53l283 342 72 daily daily JJ cord-333672-ef53l283 342 73 insulin insulin NN cord-333672-ef53l283 342 74 dose dose NN cord-333672-ef53l283 342 75 alongside alongside IN cord-333672-ef53l283 342 76 circadian circadian NN cord-333672-ef53l283 342 77 clock clock NN cord-333672-ef53l283 342 78 upregulation upregulation NN cord-333672-ef53l283 342 79 in in IN cord-333672-ef53l283 342 80 patients patient NNS cord-333672-ef53l283 342 81 with with IN cord-333672-ef53l283 342 82 type type NN cord-333672-ef53l283 342 83 2 2 CD cord-333672-ef53l283 342 84 diabetes diabete NNS cord-333672-ef53l283 342 85 consuming consume VBG cord-333672-ef53l283 342 86 a a DT cord-333672-ef53l283 342 87 three three CD cord-333672-ef53l283 342 88 - - HYPH cord-333672-ef53l283 342 89 meal meal NN cord-333672-ef53l283 342 90 diet diet NN cord-333672-ef53l283 342 91 : : : cord-333672-ef53l283 342 92 a a DT cord-333672-ef53l283 342 93 randomized randomized JJ cord-333672-ef53l283 342 94 clinical clinical JJ cord-333672-ef53l283 342 95 trial trial NN cord-333672-ef53l283 343 1 The the DT cord-333672-ef53l283 343 2 effect effect NN cord-333672-ef53l283 343 3 of of IN cord-333672-ef53l283 343 4 diurnal diurnal JJ cord-333672-ef53l283 343 5 distribution distribution NN cord-333672-ef53l283 343 6 of of IN cord-333672-ef53l283 343 7 carbohydrates carbohydrate NNS cord-333672-ef53l283 343 8 and and CC cord-333672-ef53l283 343 9 fat fat NN cord-333672-ef53l283 343 10 on on IN cord-333672-ef53l283 343 11 glycaemic glycaemic JJ cord-333672-ef53l283 343 12 control control NN cord-333672-ef53l283 343 13 in in IN cord-333672-ef53l283 343 14 humans human NNS cord-333672-ef53l283 343 15 : : : cord-333672-ef53l283 343 16 a a DT cord-333672-ef53l283 343 17 randomized randomized JJ cord-333672-ef53l283 343 18 controlled control VBN cord-333672-ef53l283 343 19 trial trial NN cord-333672-ef53l283 343 20 . . . cord-333672-ef53l283 344 1 Sci Sci NNP cord-333672-ef53l283 344 2 Rep Rep NNP cord-333672-ef53l283 344 3 Exercise Exercise NNP cord-333672-ef53l283 344 4 - - HYPH cord-333672-ef53l283 344 5 stimulated stimulate VBN cord-333672-ef53l283 344 6 glucose glucose NN cord-333672-ef53l283 344 7 uptake uptake NN cord-333672-ef53l283 344 8 -regulation -regulation NN cord-333672-ef53l283 344 9 and and CC cord-333672-ef53l283 344 10 implications implication NNS cord-333672-ef53l283 344 11 for for IN cord-333672-ef53l283 344 12 glycaemic glycaemic JJ cord-333672-ef53l283 344 13 control control NN cord-333672-ef53l283 344 14 Timing timing NN cord-333672-ef53l283 344 15 and and CC cord-333672-ef53l283 344 16 distribution distribution NN cord-333672-ef53l283 344 17 of of IN cord-333672-ef53l283 344 18 protein protein NN cord-333672-ef53l283 344 19 ingestion ingestion NN cord-333672-ef53l283 344 20 during during IN cord-333672-ef53l283 344 21 prolonged prolong VBN cord-333672-ef53l283 344 22 recovery recovery NN cord-333672-ef53l283 344 23 from from IN cord-333672-ef53l283 344 24 resistance resistance NN cord-333672-ef53l283 344 25 exercise exercise NN cord-333672-ef53l283 344 26 alters alter VBZ cord-333672-ef53l283 344 27 myofibrillar myofibrillar JJ cord-333672-ef53l283 344 28 protein protein NN cord-333672-ef53l283 344 29 synthesis synthesis NN cord-333672-ef53l283 345 1 The the DT cord-333672-ef53l283 345 2 impact impact NN cord-333672-ef53l283 345 3 of of IN cord-333672-ef53l283 345 4 food food NN cord-333672-ef53l283 345 5 order order NN cord-333672-ef53l283 345 6 on on IN cord-333672-ef53l283 345 7 postprandial postprandial JJ cord-333672-ef53l283 345 8 glycaemic glycaemic JJ cord-333672-ef53l283 345 9 excursions excursion NNS cord-333672-ef53l283 345 10 in in IN cord-333672-ef53l283 345 11 prediabetes prediabete NNS cord-333672-ef53l283 345 12 Food Food NNP cord-333672-ef53l283 345 13 order order NN cord-333672-ef53l283 345 14 has have VBZ cord-333672-ef53l283 345 15 a a DT cord-333672-ef53l283 345 16 significant significant JJ cord-333672-ef53l283 345 17 impact impact NN cord-333672-ef53l283 345 18 on on IN cord-333672-ef53l283 345 19 postprandial postprandial JJ cord-333672-ef53l283 345 20 glucose glucose NN cord-333672-ef53l283 345 21 and and CC cord-333672-ef53l283 345 22 insulin insulin NN cord-333672-ef53l283 345 23 levels level NNS cord-333672-ef53l283 346 1 Carbohydrate carbohydrate NN cord-333672-ef53l283 346 2 - - HYPH cord-333672-ef53l283 346 3 last last JJ cord-333672-ef53l283 346 4 meal meal NN cord-333672-ef53l283 346 5 pattern pattern NN cord-333672-ef53l283 346 6 lowers lower VBZ cord-333672-ef53l283 346 7 postprandial postprandial JJ cord-333672-ef53l283 346 8 glucose glucose NN cord-333672-ef53l283 346 9 and and CC cord-333672-ef53l283 346 10 insulin insulin NN cord-333672-ef53l283 346 11 excursions excursion NNS cord-333672-ef53l283 346 12 in in IN cord-333672-ef53l283 346 13 type type NN cord-333672-ef53l283 346 14 2 2 CD cord-333672-ef53l283 346 15 diabetes diabete VBZ cord-333672-ef53l283 346 16 Circadian circadian JJ cord-333672-ef53l283 346 17 physiology physiology NN cord-333672-ef53l283 346 18 of of IN cord-333672-ef53l283 346 19 metabolism metabolism NN cord-333672-ef53l283 346 20 Altering alter VBG cord-333672-ef53l283 346 21 meal meal NN cord-333672-ef53l283 346 22 timing timing NN cord-333672-ef53l283 346 23 to to TO cord-333672-ef53l283 346 24 improve improve VB cord-333672-ef53l283 346 25 cognitive cognitive JJ cord-333672-ef53l283 346 26 performance performance NN cord-333672-ef53l283 346 27 during during IN cord-333672-ef53l283 346 28 simulated simulate VBN cord-333672-ef53l283 346 29 nightshifts nightshift NNS cord-333672-ef53l283 347 1 Subjective subjective JJ cord-333672-ef53l283 347 2 hunger hunger NN cord-333672-ef53l283 347 3 , , , cord-333672-ef53l283 347 4 gastric gastric JJ cord-333672-ef53l283 347 5 upset upset JJ cord-333672-ef53l283 347 6 , , , cord-333672-ef53l283 347 7 and and CC cord-333672-ef53l283 347 8 sleepiness sleepiness NN cord-333672-ef53l283 347 9 in in IN cord-333672-ef53l283 347 10 response response NN cord-333672-ef53l283 347 11 to to IN cord-333672-ef53l283 347 12 altered alter VBN cord-333672-ef53l283 347 13 meal meal NN cord-333672-ef53l283 347 14 timing timing NN cord-333672-ef53l283 347 15 during during IN cord-333672-ef53l283 347 16 simulated simulated JJ cord-333672-ef53l283 347 17 shiftwork shiftwork NN cord-333672-ef53l283 347 18 Eating eat VBG cord-333672-ef53l283 347 19 on on IN cord-333672-ef53l283 347 20 nightshift nightshift NN cord-333672-ef53l283 347 21 : : : cord-333672-ef53l283 347 22 A a DT cord-333672-ef53l283 347 23 big big JJ cord-333672-ef53l283 347 24 vs vs IN cord-333672-ef53l283 347 25 small small JJ cord-333672-ef53l283 347 26 snack snack NN cord-333672-ef53l283 347 27 impairs impair VBZ cord-333672-ef53l283 347 28 glucose glucose NN cord-333672-ef53l283 347 29 response response NN cord-333672-ef53l283 347 30 to to IN cord-333672-ef53l283 347 31 breakfast breakfast NN cord-333672-ef53l283 347 32 Distinct distinct JJ cord-333672-ef53l283 347 33 circadian circadian NN cord-333672-ef53l283 347 34 signatures signature NNS cord-333672-ef53l283 347 35 in in IN cord-333672-ef53l283 347 36 liver liver NN cord-333672-ef53l283 347 37 and and CC cord-333672-ef53l283 347 38 gut gut NN cord-333672-ef53l283 347 39 clocks clock NNS cord-333672-ef53l283 347 40 revealed reveal VBN cord-333672-ef53l283 347 41 by by IN cord-333672-ef53l283 347 42 ketogenic ketogenic JJ cord-333672-ef53l283 347 43 diet diet NN cord-333672-ef53l283 347 44 Ketogenic Ketogenic NNP cord-333672-ef53l283 347 45 diet diet NN cord-333672-ef53l283 347 46 delays delay VBZ cord-333672-ef53l283 347 47 the the DT cord-333672-ef53l283 347 48 phase phase NN cord-333672-ef53l283 347 49 of of IN cord-333672-ef53l283 347 50 circadian circadian NN cord-333672-ef53l283 347 51 rhythms rhythm NNS cord-333672-ef53l283 347 52 and and CC cord-333672-ef53l283 347 53 does do VBZ cord-333672-ef53l283 347 54 not not RB cord-333672-ef53l283 347 55 affect affect VB cord-333672-ef53l283 347 56 AMP AMP NNP cord-333672-ef53l283 347 57 - - HYPH cord-333672-ef53l283 347 58 activated activate VBN cord-333672-ef53l283 347 59 protein protein NN cord-333672-ef53l283 347 60 kinase kinase NN cord-333672-ef53l283 347 61 ( ( -LRB- cord-333672-ef53l283 347 62 AMPK AMPK NNP cord-333672-ef53l283 347 63 ) ) -RRB- cord-333672-ef53l283 347 64 in in IN cord-333672-ef53l283 347 65 mouse mouse NN cord-333672-ef53l283 347 66 liver liver NN cord-333672-ef53l283 347 67 Ketogenic Ketogenic NNP cord-333672-ef53l283 347 68 diet diet NN cord-333672-ef53l283 347 69 and and CC cord-333672-ef53l283 347 70 fasting fasting NN cord-333672-ef53l283 347 71 induce induce VB cord-333672-ef53l283 347 72 the the DT cord-333672-ef53l283 347 73 expression expression NN cord-333672-ef53l283 347 74 of of IN cord-333672-ef53l283 347 75 cold cold JJ cord-333672-ef53l283 347 76 - - HYPH cord-333672-ef53l283 347 77 inducible inducible JJ cord-333672-ef53l283 347 78 RNA rna NN cord-333672-ef53l283 347 79 - - HYPH cord-333672-ef53l283 347 80 binding bind VBG cord-333672-ef53l283 347 81 protein protein NN cord-333672-ef53l283 347 82 with with IN cord-333672-ef53l283 347 83 timedependent timedependent NN cord-333672-ef53l283 347 84 hypothermia hypothermia NN cord-333672-ef53l283 347 85 in in IN cord-333672-ef53l283 347 86 the the DT cord-333672-ef53l283 347 87 mouse mouse NN cord-333672-ef53l283 347 88 liver liver NN cord-333672-ef53l283 347 89 Disruption disruption NN cord-333672-ef53l283 347 90 of of IN cord-333672-ef53l283 347 91 the the DT cord-333672-ef53l283 347 92 circadian circadian NN cord-333672-ef53l283 347 93 clock clock NN cord-333672-ef53l283 347 94 in in IN cord-333672-ef53l283 347 95 mice mice NN cord-333672-ef53l283 347 96 increases increase VBZ cord-333672-ef53l283 347 97 intestinal intestinal JJ cord-333672-ef53l283 347 98 permeability permeability NN cord-333672-ef53l283 347 99 and and CC cord-333672-ef53l283 347 100 promotes promote VBZ cord-333672-ef53l283 347 101 alcohol alcohol NN cord-333672-ef53l283 347 102 - - HYPH cord-333672-ef53l283 347 103 induced induce VBN cord-333672-ef53l283 347 104 hepatic hepatic JJ cord-333672-ef53l283 347 105 pathology pathology NN cord-333672-ef53l283 347 106 and and CC cord-333672-ef53l283 347 107 inflammation inflammation NN cord-333672-ef53l283 347 108 Systematic systematic JJ cord-333672-ef53l283 347 109 review review NN cord-333672-ef53l283 347 110 and and CC cord-333672-ef53l283 347 111 meta meta NN cord-333672-ef53l283 347 112 - - HYPH cord-333672-ef53l283 347 113 analysis analysis NN cord-333672-ef53l283 347 114 of of IN cord-333672-ef53l283 347 115 different different JJ cord-333672-ef53l283 347 116 dietary dietary JJ cord-333672-ef53l283 347 117 approaches approach NNS cord-333672-ef53l283 347 118 to to IN cord-333672-ef53l283 347 119 the the DT cord-333672-ef53l283 347 120 management management NN cord-333672-ef53l283 347 121 of of IN cord-333672-ef53l283 347 122 type type NN cord-333672-ef53l283 347 123 2 2 CD cord-333672-ef53l283 347 124 diabetes diabetes NN cord-333672-ef53l283 347 125 Effects effect NNS cord-333672-ef53l283 347 126 of of IN cord-333672-ef53l283 347 127 the the DT cord-333672-ef53l283 347 128 mean mean JJ cord-333672-ef53l283 347 129 amplitude amplitude NN cord-333672-ef53l283 347 130 of of IN cord-333672-ef53l283 347 131 glycemic glycemic JJ cord-333672-ef53l283 347 132 excursions excursion NNS cord-333672-ef53l283 347 133 and and CC cord-333672-ef53l283 347 134 vascular vascular JJ cord-333672-ef53l283 347 135 endothelial endothelial JJ cord-333672-ef53l283 347 136 dysfunction dysfunction NN cord-333672-ef53l283 347 137 on on IN cord-333672-ef53l283 347 138 cardiovascular cardiovascular JJ cord-333672-ef53l283 347 139 events event NNS cord-333672-ef53l283 347 140 in in IN cord-333672-ef53l283 347 141 nondiabetic nondiabetic JJ cord-333672-ef53l283 347 142 patients patient NNS cord-333672-ef53l283 347 143 with with IN cord-333672-ef53l283 347 144 coronary coronary JJ cord-333672-ef53l283 347 145 artery artery NN cord-333672-ef53l283 347 146 disease disease NN cord-333672-ef53l283 347 147 Prediabetes Prediabetes NNPS cord-333672-ef53l283 347 148 and and CC cord-333672-ef53l283 347 149 associated associate VBD cord-333672-ef53l283 347 150 disorders disorder NNS cord-333672-ef53l283 347 151 Associations association NNS cord-333672-ef53l283 347 152 of of IN cord-333672-ef53l283 347 153 prediabetes prediabete NNS cord-333672-ef53l283 347 154 with with IN cord-333672-ef53l283 347 155 all all DT cord-333672-ef53l283 347 156 - - HYPH cord-333672-ef53l283 347 157 cause cause NN cord-333672-ef53l283 347 158 and and CC cord-333672-ef53l283 347 159 cardiovascular cardiovascular JJ cord-333672-ef53l283 347 160 mortality mortality NN cord-333672-ef53l283 347 161 : : : cord-333672-ef53l283 347 162 a a DT cord-333672-ef53l283 347 163 meta meta JJ cord-333672-ef53l283 347 164 - - HYPH cord-333672-ef53l283 347 165 analysis analysis NN cord-333672-ef53l283 347 166 Prediabetes prediabete NNS cord-333672-ef53l283 347 167 and and CC cord-333672-ef53l283 347 168 the the DT cord-333672-ef53l283 347 169 risk risk NN cord-333672-ef53l283 347 170 of of IN cord-333672-ef53l283 347 171 cancer cancer NN cord-333672-ef53l283 347 172 : : : cord-333672-ef53l283 347 173 a a DT cord-333672-ef53l283 347 174 meta meta JJ cord-333672-ef53l283 347 175 - - HYPH cord-333672-ef53l283 347 176 analysis analysis NN cord-333672-ef53l283 347 177 Glucose glucose NN cord-333672-ef53l283 347 178 peaks peak NNS cord-333672-ef53l283 347 179 and and CC cord-333672-ef53l283 347 180 the the DT cord-333672-ef53l283 347 181 risk risk NN cord-333672-ef53l283 347 182 of of IN cord-333672-ef53l283 347 183 dementia dementia NN cord-333672-ef53l283 347 184 and and CC cord-333672-ef53l283 347 185 20-year 20-year JJ cord-333672-ef53l283 347 186 cognitive cognitive JJ cord-333672-ef53l283 347 187 decline decline NN cord-333672-ef53l283 347 188 . . . cord-333672-ef53l283 348 1 Diabetes diabetes NN cord-333672-ef53l283 348 2 Care care VBP cord-333672-ef53l283 348 3 Improvement improvement NN cord-333672-ef53l283 348 4 in in IN cord-333672-ef53l283 348 5 patient patient NN cord-333672-ef53l283 348 6 - - HYPH cord-333672-ef53l283 348 7 reported report VBN cord-333672-ef53l283 348 8 sleep sleep NN cord-333672-ef53l283 348 9 in in IN cord-333672-ef53l283 348 10 type type NN cord-333672-ef53l283 348 11 2 2 CD cord-333672-ef53l283 348 12 diabetes diabete NNS cord-333672-ef53l283 348 13 and and CC cord-333672-ef53l283 348 14 prediabetes prediabete VBZ cord-333672-ef53l283 348 15 participants participant NNS cord-333672-ef53l283 348 16 receiving receive VBG cord-333672-ef53l283 348 17 a a DT cord-333672-ef53l283 348 18 continuous continuous JJ cord-333672-ef53l283 348 19 care care NN cord-333672-ef53l283 348 20 intervention intervention NN cord-333672-ef53l283 348 21 with with IN cord-333672-ef53l283 348 22 nutritional nutritional JJ cord-333672-ef53l283 348 23 ketosis ketosis NN cord-333672-ef53l283 348 24 β β NNP cord-333672-ef53l283 348 25 - - HYPH cord-333672-ef53l283 348 26 Hydroxybutyrate Hydroxybutyrate NNP cord-333672-ef53l283 348 27 : : : cord-333672-ef53l283 348 28 a a DT cord-333672-ef53l283 348 29 signaling signal VBG cord-333672-ef53l283 348 30 metabolite metabolite NN cord-333672-ef53l283 349 1 A a DT cord-333672-ef53l283 349 2 ketogenic ketogenic JJ cord-333672-ef53l283 349 3 diet diet NN cord-333672-ef53l283 349 4 extends extend VBZ cord-333672-ef53l283 349 5 longevity longevity NN cord-333672-ef53l283 349 6 and and CC cord-333672-ef53l283 349 7 healthspan healthspan NN cord-333672-ef53l283 349 8 in in IN cord-333672-ef53l283 349 9 adult adult NN cord-333672-ef53l283 349 10 mice mouse NNS cord-333672-ef53l283 350 1 Ketogenic ketogenic JJ cord-333672-ef53l283 350 2 diet diet NN cord-333672-ef53l283 350 3 improves improve VBZ cord-333672-ef53l283 350 4 the the DT cord-333672-ef53l283 350 5 spatial spatial JJ cord-333672-ef53l283 350 6 memory memory NN cord-333672-ef53l283 350 7 impairment impairment NN cord-333672-ef53l283 350 8 caused cause VBN cord-333672-ef53l283 350 9 by by IN cord-333672-ef53l283 350 10 exposure exposure NN cord-333672-ef53l283 350 11 to to IN cord-333672-ef53l283 350 12 hypobaric hypobaric NN cord-333672-ef53l283 350 13 hypoxia hypoxia NN cord-333672-ef53l283 350 14 through through IN cord-333672-ef53l283 350 15 increased increase VBN cord-333672-ef53l283 350 16 acetylation acetylation NN cord-333672-ef53l283 350 17 of of IN cord-333672-ef53l283 350 18 histones histone NNS cord-333672-ef53l283 350 19 in in IN cord-333672-ef53l283 350 20 rats rat NNS cord-333672-ef53l283 350 21 Shift shift VBP cord-333672-ef53l283 350 22 work work NN cord-333672-ef53l283 350 23 and and CC cord-333672-ef53l283 350 24 risk risk NN cord-333672-ef53l283 350 25 of of IN cord-333672-ef53l283 350 26 incident incident NN cord-333672-ef53l283 350 27 dementia dementia NN cord-333672-ef53l283 350 28 : : : cord-333672-ef53l283 350 29 a a DT cord-333672-ef53l283 350 30 study study NN cord-333672-ef53l283 350 31 of of IN cord-333672-ef53l283 350 32 two two CD cord-333672-ef53l283 350 33 population population NN cord-333672-ef53l283 350 34 - - HYPH cord-333672-ef53l283 350 35 based base VBN cord-333672-ef53l283 350 36 cohorts cohort NNS cord-333672-ef53l283 350 37 Night Night NNP cord-333672-ef53l283 350 38 shift shift NN cord-333672-ef53l283 350 39 work work NN cord-333672-ef53l283 350 40 , , , cord-333672-ef53l283 350 41 long long JJ cord-333672-ef53l283 350 42 working working NN cord-333672-ef53l283 350 43 hours hour NNS cord-333672-ef53l283 350 44 and and CC cord-333672-ef53l283 350 45 dementia dementia NN cord-333672-ef53l283 350 46 : : : cord-333672-ef53l283 351 1 a a DT cord-333672-ef53l283 351 2 longitudinal longitudinal JJ cord-333672-ef53l283 351 3 study study NN cord-333672-ef53l283 351 4 of of IN cord-333672-ef53l283 351 5 the the DT cord-333672-ef53l283 351 6 danish danish JJ cord-333672-ef53l283 351 7 work work NNP cord-333672-ef53l283 351 8 environment environment NN cord-333672-ef53l283 351 9 cohort cohort NN cord-333672-ef53l283 351 10 study study NN cord-333672-ef53l283 351 11 Interdependence Interdependence NNP cord-333672-ef53l283 351 12 of of IN cord-333672-ef53l283 351 13 nutrient nutrient NN cord-333672-ef53l283 351 14 metabolism metabolism NN cord-333672-ef53l283 351 15 and and CC cord-333672-ef53l283 351 16 the the DT cord-333672-ef53l283 351 17 circadian circadian NN cord-333672-ef53l283 351 18 clock clock NN cord-333672-ef53l283 351 19 system system NN cord-333672-ef53l283 351 20 : : : cord-333672-ef53l283 351 21 importance importance NN cord-333672-ef53l283 351 22 for for IN cord-333672-ef53l283 351 23 metabolic metabolic JJ cord-333672-ef53l283 351 24 health health NN cord-333672-ef53l283 351 25 Effects effect NNS cord-333672-ef53l283 351 26 of of IN cord-333672-ef53l283 351 27 diet diet NN cord-333672-ef53l283 351 28 on on IN cord-333672-ef53l283 351 29 sleep sleep NN cord-333672-ef53l283 351 30 quality quality NN cord-333672-ef53l283 351 31 Regulation regulation NN cord-333672-ef53l283 351 32 of of IN cord-333672-ef53l283 351 33 circadian circadian NN cord-333672-ef53l283 351 34 behaviour behaviour NN cord-333672-ef53l283 351 35 and and CC cord-333672-ef53l283 351 36 metabolism metabolism NN cord-333672-ef53l283 351 37 by by IN cord-333672-ef53l283 351 38 synthetic synthetic JJ cord-333672-ef53l283 351 39 REV REV NNP cord-333672-ef53l283 351 40 - - HYPH cord-333672-ef53l283 351 41 ERB ERB NNP cord-333672-ef53l283 351 42 agonists agonist NNS cord-333672-ef53l283 351 43 Caffeine Caffeine NNP cord-333672-ef53l283 351 44 for for IN cord-333672-ef53l283 351 45 the the DT cord-333672-ef53l283 351 46 prevention prevention NN cord-333672-ef53l283 351 47 of of IN cord-333672-ef53l283 351 48 injuries injury NNS cord-333672-ef53l283 351 49 and and CC cord-333672-ef53l283 351 50 errors error NNS cord-333672-ef53l283 351 51 in in IN cord-333672-ef53l283 351 52 shift shift NN cord-333672-ef53l283 351 53 workers worker NNS cord-333672-ef53l283 351 54 Coffee Coffee NNP cord-333672-ef53l283 351 55 , , , cord-333672-ef53l283 351 56 caffeine caffeine NN cord-333672-ef53l283 351 57 , , , cord-333672-ef53l283 351 58 and and CC cord-333672-ef53l283 351 59 sleep sleep NN cord-333672-ef53l283 351 60 : : : cord-333672-ef53l283 351 61 a a DT cord-333672-ef53l283 351 62 systematic systematic JJ cord-333672-ef53l283 351 63 review review NN cord-333672-ef53l283 351 64 of of IN cord-333672-ef53l283 351 65 epidemiological epidemiological JJ cord-333672-ef53l283 351 66 studies study NNS cord-333672-ef53l283 351 67 and and CC cord-333672-ef53l283 351 68 randomized randomize VBN cord-333672-ef53l283 351 69 controlled control VBN cord-333672-ef53l283 351 70 trials trial NNS cord-333672-ef53l283 351 71 Effects effect NNS cord-333672-ef53l283 351 72 of of IN cord-333672-ef53l283 351 73 caffeine caffeine NN cord-333672-ef53l283 351 74 on on IN cord-333672-ef53l283 351 75 the the DT cord-333672-ef53l283 351 76 human human JJ cord-333672-ef53l283 351 77 circadian circadian NN cord-333672-ef53l283 351 78 clock clock NN cord-333672-ef53l283 351 79 in in IN cord-333672-ef53l283 351 80 vivo vivo NN cord-333672-ef53l283 351 81 and and CC cord-333672-ef53l283 351 82 in in IN cord-333672-ef53l283 351 83 vitro vitro FW cord-333672-ef53l283 351 84 Creatine creatine NN cord-333672-ef53l283 351 85 supplementation supplementation NN cord-333672-ef53l283 351 86 reduces reduce VBZ cord-333672-ef53l283 351 87 sleep sleep NN cord-333672-ef53l283 351 88 need need NN cord-333672-ef53l283 351 89 and and CC cord-333672-ef53l283 351 90 homeostatic homeostatic JJ cord-333672-ef53l283 351 91 sleep sleep NN cord-333672-ef53l283 351 92 pressure pressure NN cord-333672-ef53l283 351 93 in in IN cord-333672-ef53l283 351 94 rats rat NNS cord-333672-ef53l283 351 95 International international JJ cord-333672-ef53l283 351 96 society society NN cord-333672-ef53l283 351 97 of of IN cord-333672-ef53l283 351 98 sports sport NNS cord-333672-ef53l283 351 99 nutrition nutrition NN cord-333672-ef53l283 351 100 position position NN cord-333672-ef53l283 351 101 stand stand NN cord-333672-ef53l283 351 102 : : : cord-333672-ef53l283 351 103 safety safety NN cord-333672-ef53l283 351 104 and and CC cord-333672-ef53l283 351 105 efficacy efficacy NN cord-333672-ef53l283 351 106 of of IN cord-333672-ef53l283 351 107 creatine creatine NN cord-333672-ef53l283 351 108 supplementation supplementation NN cord-333672-ef53l283 351 109 in in IN cord-333672-ef53l283 351 110 exercise exercise NN cord-333672-ef53l283 351 111 , , , cord-333672-ef53l283 351 112 sport sport NN cord-333672-ef53l283 351 113 , , , cord-333672-ef53l283 351 114 and and CC cord-333672-ef53l283 351 115 medicine medicine NN cord-333672-ef53l283 351 116 Creatine Creatine NNP cord-333672-ef53l283 351 117 supplementation supplementation NN cord-333672-ef53l283 351 118 , , , cord-333672-ef53l283 351 119 sleep sleep NN cord-333672-ef53l283 351 120 deprivation deprivation NN cord-333672-ef53l283 351 121 , , , cord-333672-ef53l283 351 122 cortisol cortisol NN cord-333672-ef53l283 351 123 , , , cord-333672-ef53l283 351 124 melatonin melatonin NN cord-333672-ef53l283 351 125 and and CC cord-333672-ef53l283 351 126 behavior behavior NN cord-333672-ef53l283 352 1 Effect effect NN cord-333672-ef53l283 352 2 of of IN cord-333672-ef53l283 352 3 creatine creatine NN cord-333672-ef53l283 352 4 supplementation supplementation NN cord-333672-ef53l283 352 5 and and CC cord-333672-ef53l283 352 6 sleep sleep NN cord-333672-ef53l283 352 7 deprivation deprivation NN cord-333672-ef53l283 352 8 , , , cord-333672-ef53l283 352 9 with with IN cord-333672-ef53l283 352 10 mild mild JJ cord-333672-ef53l283 352 11 exercise exercise NN cord-333672-ef53l283 352 12 , , , cord-333672-ef53l283 352 13 on on IN cord-333672-ef53l283 352 14 cognitive cognitive JJ cord-333672-ef53l283 352 15 and and CC cord-333672-ef53l283 352 16 psychomotor psychomotor JJ cord-333672-ef53l283 352 17 performance performance NN cord-333672-ef53l283 352 18 , , , cord-333672-ef53l283 352 19 mood mood NN cord-333672-ef53l283 352 20 state state NN cord-333672-ef53l283 352 21 , , , cord-333672-ef53l283 352 22 and and CC cord-333672-ef53l283 352 23 plasma plasma NN cord-333672-ef53l283 352 24 concentrations concentration NNS cord-333672-ef53l283 352 25 of of IN cord-333672-ef53l283 352 26 catecholamines catecholamine NNS cord-333672-ef53l283 352 27 and and CC cord-333672-ef53l283 352 28 cortisol cortisol NN cord-333672-ef53l283 352 29 Skill skill NN cord-333672-ef53l283 352 30 execution execution NN cord-333672-ef53l283 352 31 and and CC cord-333672-ef53l283 352 32 sleep sleep NN cord-333672-ef53l283 352 33 deprivation deprivation NN cord-333672-ef53l283 352 34 : : : cord-333672-ef53l283 352 35 effects effect NNS cord-333672-ef53l283 352 36 of of IN cord-333672-ef53l283 352 37 acute acute JJ cord-333672-ef53l283 352 38 caffeine caffeine NN cord-333672-ef53l283 352 39 or or CC cord-333672-ef53l283 352 40 creatine creatine NN cord-333672-ef53l283 352 41 supplementation supplementation NN cord-333672-ef53l283 352 42 -a -a HYPH cord-333672-ef53l283 352 43 randomized randomized JJ cord-333672-ef53l283 352 44 placebo placebo NN cord-333672-ef53l283 352 45 - - HYPH cord-333672-ef53l283 352 46 controlled control VBN cord-333672-ef53l283 352 47 trial trial NN cord-333672-ef53l283 352 48 Creatine creatine NN cord-333672-ef53l283 352 49 and and CC cord-333672-ef53l283 352 50 caffeine caffeine NN cord-333672-ef53l283 352 51 : : : cord-333672-ef53l283 352 52 considerations consideration NNS cord-333672-ef53l283 352 53 for for IN cord-333672-ef53l283 352 54 concurrent concurrent JJ cord-333672-ef53l283 352 55 supplementation supplementation NN cord-333672-ef53l283 353 1 The the DT cord-333672-ef53l283 353 2 circadian circadian JJ cord-333672-ef53l283 353 3 rhythm rhythm NN cord-333672-ef53l283 353 4 of of IN cord-333672-ef53l283 353 5 tryptophan tryptophan NN cord-333672-ef53l283 353 6 in in IN cord-333672-ef53l283 353 7 breast breast NN cord-333672-ef53l283 353 8 milk milk NN cord-333672-ef53l283 353 9 affects affect VBZ cord-333672-ef53l283 353 10 the the DT cord-333672-ef53l283 353 11 rhythms rhythm NNS cord-333672-ef53l283 353 12 of of IN cord-333672-ef53l283 353 13 6-sulfatoxymelatonin 6-sulfatoxymelatonin CD cord-333672-ef53l283 353 14 and and CC cord-333672-ef53l283 353 15 sleep sleep NN cord-333672-ef53l283 353 16 in in IN cord-333672-ef53l283 353 17 newborn newborn JJ cord-333672-ef53l283 353 18 Improved improve VBN cord-333672-ef53l283 353 19 circadian circadian NN cord-333672-ef53l283 353 20 sleep sleep NN cord-333672-ef53l283 353 21 - - HYPH cord-333672-ef53l283 353 22 wake wake NN cord-333672-ef53l283 353 23 cycle cycle NN cord-333672-ef53l283 353 24 in in IN cord-333672-ef53l283 353 25 infants infant NNS cord-333672-ef53l283 353 26 fed feed VBD cord-333672-ef53l283 353 27 a a DT cord-333672-ef53l283 353 28 day day NN cord-333672-ef53l283 353 29 / / SYM cord-333672-ef53l283 353 30 night night NN cord-333672-ef53l283 353 31 dissociated dissociate VBN cord-333672-ef53l283 353 32 formula formula NN cord-333672-ef53l283 353 33 milk milk NN cord-333672-ef53l283 353 34 Effects effect NNS cord-333672-ef53l283 353 35 of of IN cord-333672-ef53l283 353 36 tryptophan tryptophan NN cord-333672-ef53l283 353 37 loading load VBG cord-333672-ef53l283 353 38 on on IN cord-333672-ef53l283 353 39 human human JJ cord-333672-ef53l283 353 40 cognition cognition NN cord-333672-ef53l283 353 41 , , , cord-333672-ef53l283 353 42 mood mood NN cord-333672-ef53l283 353 43 , , , cord-333672-ef53l283 353 44 and and CC cord-333672-ef53l283 353 45 sleep sleep VB cord-333672-ef53l283 353 46 l l NN cord-333672-ef53l283 353 47 - - HYPH cord-333672-ef53l283 353 48 Serine Serine NNP cord-333672-ef53l283 353 49 enhances enhance VBZ cord-333672-ef53l283 353 50 light light NN cord-333672-ef53l283 353 51 - - HYPH cord-333672-ef53l283 353 52 induced induce VBN cord-333672-ef53l283 353 53 circadian circadian NN cord-333672-ef53l283 353 54 phase phase NN cord-333672-ef53l283 353 55 resetting reset VBG cord-333672-ef53l283 353 56 in in IN cord-333672-ef53l283 353 57 mice mouse NNS cord-333672-ef53l283 353 58 and and CC cord-333672-ef53l283 353 59 humans human NNS cord-333672-ef53l283 354 1 A a DT cord-333672-ef53l283 354 2 randomized randomized JJ cord-333672-ef53l283 354 3 , , , cord-333672-ef53l283 354 4 double double JJ cord-333672-ef53l283 354 5 - - HYPH cord-333672-ef53l283 354 6 blind blind JJ cord-333672-ef53l283 354 7 and and CC cord-333672-ef53l283 354 8 placebo placebo NN cord-333672-ef53l283 354 9 - - HYPH cord-333672-ef53l283 354 10 controlled control VBN cord-333672-ef53l283 354 11 crossover crossover NN cord-333672-ef53l283 354 12 trial trial NN cord-333672-ef53l283 354 13 on on IN cord-333672-ef53l283 354 14 the the DT cord-333672-ef53l283 354 15 effect effect NN cord-333672-ef53l283 354 16 of of IN cord-333672-ef53l283 354 17 l l NN cord-333672-ef53l283 354 18 - - HYPH cord-333672-ef53l283 354 19 ornithine ornithine NN cord-333672-ef53l283 354 20 ingestion ingestion NN cord-333672-ef53l283 354 21 on on IN cord-333672-ef53l283 354 22 the the DT cord-333672-ef53l283 354 23 human human JJ cord-333672-ef53l283 354 24 circadian circadian NN cord-333672-ef53l283 354 25 clock clock NN cord-333672-ef53l283 355 1 Ornithine ornithine JJ cord-333672-ef53l283 355 2 ingestion ingestion NN cord-333672-ef53l283 355 3 improved improve VBD cord-333672-ef53l283 355 4 sleep sleep NN cord-333672-ef53l283 355 5 disturbances disturbance NNS cord-333672-ef53l283 355 6 but but CC cord-333672-ef53l283 355 7 was be VBD cord-333672-ef53l283 355 8 not not RB cord-333672-ef53l283 355 9 associated associate VBN cord-333672-ef53l283 355 10 with with IN cord-333672-ef53l283 355 11 correction correction NN cord-333672-ef53l283 355 12 of of IN cord-333672-ef53l283 355 13 blood blood NN cord-333672-ef53l283 355 14 tryptophan tryptophan NN cord-333672-ef53l283 355 15 ratio ratio NN cord-333672-ef53l283 355 16 in in IN cord-333672-ef53l283 355 17 Japanese japanese JJ cord-333672-ef53l283 355 18 antarctica antarctica NNP cord-333672-ef53l283 355 19 expedition expedition NN cord-333672-ef53l283 355 20 members member NNS cord-333672-ef53l283 355 21 during during IN cord-333672-ef53l283 355 22 summer summer NN cord-333672-ef53l283 355 23 Randomised Randomised NNP cord-333672-ef53l283 355 24 controlled control VBN cord-333672-ef53l283 355 25 trial trial NN cord-333672-ef53l283 355 26 of of IN cord-333672-ef53l283 355 27 the the DT cord-333672-ef53l283 355 28 effects effect NNS cord-333672-ef53l283 355 29 of of IN cord-333672-ef53l283 355 30 L l NN cord-333672-ef53l283 355 31 - - HYPH cord-333672-ef53l283 355 32 ornithine ornithine NN cord-333672-ef53l283 355 33 on on IN cord-333672-ef53l283 355 34 stress stress NN cord-333672-ef53l283 355 35 markers marker NNS cord-333672-ef53l283 355 36 and and CC cord-333672-ef53l283 355 37 sleep sleep VB cord-333672-ef53l283 355 38 quality quality NN cord-333672-ef53l283 355 39 in in IN cord-333672-ef53l283 355 40 healthy healthy JJ cord-333672-ef53l283 355 41 workers worker NNS cord-333672-ef53l283 356 1 Glycine glycine NN cord-333672-ef53l283 356 2 ingestion ingestion NN cord-333672-ef53l283 356 3 improves improve VBZ cord-333672-ef53l283 356 4 subjective subjective JJ cord-333672-ef53l283 356 5 sleep sleep NN cord-333672-ef53l283 356 6 quality quality NN cord-333672-ef53l283 356 7 in in IN cord-333672-ef53l283 356 8 human human JJ cord-333672-ef53l283 356 9 volunteers volunteer NNS cord-333672-ef53l283 356 10 , , , cord-333672-ef53l283 356 11 correlating correlate VBG cord-333672-ef53l283 356 12 with with IN cord-333672-ef53l283 356 13 polysomnographic polysomnographic JJ cord-333672-ef53l283 356 14 changes change VBZ cord-333672-ef53l283 356 15 The the DT cord-333672-ef53l283 356 16 sleep sleep NN cord-333672-ef53l283 356 17 - - HYPH cord-333672-ef53l283 356 18 promoting promote VBG cord-333672-ef53l283 356 19 and and CC cord-333672-ef53l283 356 20 hypothermic hypothermic JJ cord-333672-ef53l283 356 21 effects effect NNS cord-333672-ef53l283 356 22 of of IN cord-333672-ef53l283 356 23 glycine glycine NN cord-333672-ef53l283 356 24 are be VBP cord-333672-ef53l283 356 25 mediated mediate VBN cord-333672-ef53l283 356 26 by by IN cord-333672-ef53l283 356 27 NMDA NMDA NNP cord-333672-ef53l283 356 28 receptors receptor NNS cord-333672-ef53l283 356 29 in in IN cord-333672-ef53l283 356 30 the the DT cord-333672-ef53l283 356 31 suprachiasmatic suprachiasmatic NN cord-333672-ef53l283 356 32 nucleus nucleus NN cord-333672-ef53l283 357 1 The the DT cord-333672-ef53l283 357 2 effects effect NNS cord-333672-ef53l283 357 3 of of IN cord-333672-ef53l283 357 4 glycine glycine NN cord-333672-ef53l283 357 5 on on IN cord-333672-ef53l283 357 6 subjective subjective JJ cord-333672-ef53l283 357 7 daytime daytime JJ cord-333672-ef53l283 357 8 performance performance NN cord-333672-ef53l283 357 9 in in IN cord-333672-ef53l283 357 10 partially partially RB cord-333672-ef53l283 357 11 sleep sleep NN cord-333672-ef53l283 357 12 - - HYPH cord-333672-ef53l283 357 13 restricted restrict VBN cord-333672-ef53l283 357 14 healthy healthy JJ cord-333672-ef53l283 357 15 volunteers volunteer NNS cord-333672-ef53l283 357 16 Glycine glycine JJ cord-333672-ef53l283 357 17 metabolism metabolism NN cord-333672-ef53l283 357 18 in in IN cord-333672-ef53l283 357 19 animals animal NNS cord-333672-ef53l283 357 20 and and CC cord-333672-ef53l283 357 21 humans human NNS cord-333672-ef53l283 357 22 : : : cord-333672-ef53l283 357 23 implications implication NNS cord-333672-ef53l283 357 24 for for IN cord-333672-ef53l283 357 25 nutrition nutrition NN cord-333672-ef53l283 357 26 and and CC cord-333672-ef53l283 357 27 health health NN cord-333672-ef53l283 357 28 A a DT cord-333672-ef53l283 357 29 smartphone smartphone NN cord-333672-ef53l283 357 30 app app NN cord-333672-ef53l283 357 31 reveals reveal VBZ cord-333672-ef53l283 357 32 erratic erratic JJ cord-333672-ef53l283 357 33 diurnal diurnal JJ cord-333672-ef53l283 357 34 eating eat VBG cord-333672-ef53l283 357 35 patterns pattern NNS cord-333672-ef53l283 357 36 in in IN cord-333672-ef53l283 357 37 humans human NNS cord-333672-ef53l283 357 38 that that WDT cord-333672-ef53l283 357 39 can can MD cord-333672-ef53l283 357 40 be be VB cord-333672-ef53l283 357 41 modulated modulate VBN cord-333672-ef53l283 357 42 for for IN cord-333672-ef53l283 357 43 health health NN cord-333672-ef53l283 357 44 benefits benefit NNS cord-333672-ef53l283 358 1 A a DT cord-333672-ef53l283 358 2 pilot pilot NN cord-333672-ef53l283 358 3 characterization characterization NN cord-333672-ef53l283 358 4 of of IN cord-333672-ef53l283 358 5 the the DT cord-333672-ef53l283 358 6 human human JJ cord-333672-ef53l283 358 7 chronobiome chronobiome NN cord-333672-ef53l283 358 8 Noninvasive noninvasive JJ cord-333672-ef53l283 358 9 hemoglobin hemoglobin NN cord-333672-ef53l283 358 10 measurement measurement NN cord-333672-ef53l283 358 11 using use VBG cord-333672-ef53l283 358 12 unmodified unmodified JJ cord-333672-ef53l283 358 13 smartphone smartphone NN cord-333672-ef53l283 358 14 camera camera NN cord-333672-ef53l283 358 15 and and CC cord-333672-ef53l283 358 16 white white JJ cord-333672-ef53l283 358 17 flash flash NNP cord-333672-ef53l283 358 18 Digital Digital NNP cord-333672-ef53l283 358 19 envirotyping envirotyping NN cord-333672-ef53l283 358 20 : : : cord-333672-ef53l283 358 21 quantifying quantify VBG cord-333672-ef53l283 358 22 environmental environmental JJ cord-333672-ef53l283 358 23 determinants determinant NNS cord-333672-ef53l283 358 24 of of IN cord-333672-ef53l283 358 25 health health NN cord-333672-ef53l283 358 26 and and CC cord-333672-ef53l283 358 27 behavior behavior NN cord-333672-ef53l283 359 1 Relapse relapse NN cord-333672-ef53l283 359 2 prediction prediction NN cord-333672-ef53l283 359 3 in in IN cord-333672-ef53l283 359 4 schizophrenia schizophrenia NN cord-333672-ef53l283 359 5 through through IN cord-333672-ef53l283 359 6 digital digital JJ cord-333672-ef53l283 359 7 phenotyping phenotyping NN cord-333672-ef53l283 359 8 : : : cord-333672-ef53l283 359 9 a a DT cord-333672-ef53l283 359 10 pilot pilot NN cord-333672-ef53l283 359 11 study study NN cord-333672-ef53l283 359 12 A a DT cord-333672-ef53l283 359 13 comparison comparison NN cord-333672-ef53l283 359 14 of of IN cord-333672-ef53l283 359 15 passive passive JJ cord-333672-ef53l283 359 16 and and CC cord-333672-ef53l283 359 17 active active JJ cord-333672-ef53l283 359 18 estimates estimate NNS cord-333672-ef53l283 359 19 of of IN cord-333672-ef53l283 359 20 sleep sleep NN cord-333672-ef53l283 359 21 in in IN cord-333672-ef53l283 359 22 a a DT cord-333672-ef53l283 359 23 cohort cohort NN cord-333672-ef53l283 359 24 with with IN cord-333672-ef53l283 359 25 schizophrenia schizophrenia NN cord-333672-ef53l283 359 26 Wearable wearable JJ cord-333672-ef53l283 359 27 biosensors biosensor NNS cord-333672-ef53l283 359 28 for for IN cord-333672-ef53l283 359 29 healthcare healthcare NN cord-333672-ef53l283 359 30 monitoring monitor VBG cord-333672-ef53l283 359 31 High high JJ cord-333672-ef53l283 359 32 - - HYPH cord-333672-ef53l283 359 33 performance performance NN cord-333672-ef53l283 359 34 medicine medicine NN cord-333672-ef53l283 359 35 : : : cord-333672-ef53l283 359 36 the the DT cord-333672-ef53l283 359 37 convergence convergence NN cord-333672-ef53l283 359 38 of of IN cord-333672-ef53l283 359 39 human human JJ cord-333672-ef53l283 359 40 and and CC cord-333672-ef53l283 359 41 artificial artificial JJ cord-333672-ef53l283 359 42 intelligence intelligence NN cord-333672-ef53l283 359 43 Effects effect NNS cord-333672-ef53l283 359 44 of of IN cord-333672-ef53l283 359 45 circadian circadian NN cord-333672-ef53l283 359 46 misalignment misalignment NN cord-333672-ef53l283 359 47 on on IN cord-333672-ef53l283 359 48 cognition cognition NN cord-333672-ef53l283 359 49 in in IN cord-333672-ef53l283 359 50 chronic chronic JJ cord-333672-ef53l283 359 51 shift shift NN cord-333672-ef53l283 359 52 workers worker NNS cord-333672-ef53l283 360 1 The the DT cord-333672-ef53l283 360 2 sleep sleep NN cord-333672-ef53l283 360 3 - - HYPH cord-333672-ef53l283 360 4 deprived deprive VBN cord-333672-ef53l283 360 5 human human JJ cord-333672-ef53l283 360 6 brain brain NN cord-333672-ef53l283 361 1 Why why WRB cord-333672-ef53l283 361 2 is be VBZ cord-333672-ef53l283 361 3 changing change VBG cord-333672-ef53l283 361 4 health health NN cord-333672-ef53l283 361 5 - - HYPH cord-333672-ef53l283 361 6 related relate VBN cord-333672-ef53l283 361 7 behaviour behaviour NN cord-333672-ef53l283 361 8 so so RB cord-333672-ef53l283 361 9 difficult difficult JJ cord-333672-ef53l283 361 10 ? ? . cord-333672-ef53l283 362 1 Public Public NNP cord-333672-ef53l283 362 2 Health Health NNP cord-333672-ef53l283 363 1 Just just RB cord-333672-ef53l283 363 2 - - HYPH cord-333672-ef53l283 363 3 in in IN cord-333672-ef53l283 363 4 - - HYPH cord-333672-ef53l283 363 5 time time NN cord-333672-ef53l283 363 6 adaptive adaptive JJ cord-333672-ef53l283 363 7 interventions intervention NNS cord-333672-ef53l283 363 8 ( ( -LRB- cord-333672-ef53l283 363 9 JITAIs JITAIs NNPS cord-333672-ef53l283 363 10 ) ) -RRB- cord-333672-ef53l283 363 11 in in IN cord-333672-ef53l283 363 12 mobile mobile JJ cord-333672-ef53l283 363 13 health health NN cord-333672-ef53l283 363 14 : : : cord-333672-ef53l283 364 1 key key JJ cord-333672-ef53l283 364 2 components component NNS cord-333672-ef53l283 364 3 and and CC cord-333672-ef53l283 364 4 design design NN cord-333672-ef53l283 364 5 principles principle NNS cord-333672-ef53l283 364 6 for for IN cord-333672-ef53l283 364 7 ongoing ongoing JJ cord-333672-ef53l283 364 8 health health NN cord-333672-ef53l283 364 9 behavior behavior NN cord-333672-ef53l283 364 10 support support VBP cord-333672-ef53l283 364 11 Health Health NNP cord-333672-ef53l283 364 12 and and CC cord-333672-ef53l283 364 13 the the DT cord-333672-ef53l283 364 14 built build VBN cord-333672-ef53l283 364 15 environment environment NN cord-333672-ef53l283 364 16 : : : cord-333672-ef53l283 364 17 10 10 CD cord-333672-ef53l283 364 18 years year NNS cord-333672-ef53l283 364 19 after after IN cord-333672-ef53l283 364 20 Effects effect NNS cord-333672-ef53l283 364 21 of of IN cord-333672-ef53l283 364 22 the the DT cord-333672-ef53l283 364 23 internal internal JJ cord-333672-ef53l283 364 24 circadian circadian NN cord-333672-ef53l283 364 25 system system NN cord-333672-ef53l283 364 26 and and CC cord-333672-ef53l283 364 27 circadian circadian NN cord-333672-ef53l283 364 28 misalignment misalignment NN cord-333672-ef53l283 364 29 on on IN cord-333672-ef53l283 364 30 glucose glucose NN cord-333672-ef53l283 364 31 tolerance tolerance NN cord-333672-ef53l283 364 32 in in IN cord-333672-ef53l283 364 33 chronic chronic JJ cord-333672-ef53l283 364 34 shift shift NN cord-333672-ef53l283 364 35 workers worker NNS cord-333672-ef53l283 364 36 Vending Vending NNP cord-333672-ef53l283 364 37 assessment assessment NN cord-333672-ef53l283 364 38 and and CC cord-333672-ef53l283 364 39 program program NN cord-333672-ef53l283 364 40 implementation implementation NN cord-333672-ef53l283 364 41 in in IN cord-333672-ef53l283 364 42 four four CD cord-333672-ef53l283 364 43 iowa iowa NNP cord-333672-ef53l283 364 44 worksites worksite NNS cord-333672-ef53l283 365 1 A a DT cord-333672-ef53l283 365 2 workplace workplace NN cord-333672-ef53l283 365 3 feasibility feasibility NN cord-333672-ef53l283 365 4 study study NN cord-333672-ef53l283 365 5 of of IN cord-333672-ef53l283 365 6 the the DT cord-333672-ef53l283 365 7 effect effect NN cord-333672-ef53l283 365 8 of of IN cord-333672-ef53l283 365 9 a a DT cord-333672-ef53l283 365 10 minimal minimal JJ cord-333672-ef53l283 365 11 fruit fruit NN cord-333672-ef53l283 365 12 intervention intervention NN cord-333672-ef53l283 365 13 on on IN cord-333672-ef53l283 365 14 fruit fruit NN cord-333672-ef53l283 365 15 intake intake NN cord-333672-ef53l283 365 16 Effectiveness Effectiveness NNP cord-333672-ef53l283 365 17 of of IN cord-333672-ef53l283 365 18 offering offer VBG cord-333672-ef53l283 365 19 healthy healthy JJ cord-333672-ef53l283 365 20 labelled label VBN cord-333672-ef53l283 365 21 meals meal NNS cord-333672-ef53l283 365 22 in in IN cord-333672-ef53l283 365 23 improving improve VBG cord-333672-ef53l283 365 24 the the DT cord-333672-ef53l283 365 25 nutritional nutritional JJ cord-333672-ef53l283 365 26 quality quality NN cord-333672-ef53l283 365 27 of of IN cord-333672-ef53l283 365 28 lunch lunch NN cord-333672-ef53l283 365 29 meals meal NNS cord-333672-ef53l283 365 30 eaten eat VBN cord-333672-ef53l283 365 31 in in IN cord-333672-ef53l283 365 32 a a DT cord-333672-ef53l283 365 33 worksite worksite NN cord-333672-ef53l283 365 34 canteen canteen NN cord-333672-ef53l283 365 35 Nudging nudge VBG cord-333672-ef53l283 365 36 consumers consumer NNS cord-333672-ef53l283 365 37 towards towards IN cord-333672-ef53l283 365 38 healthier healthy JJR cord-333672-ef53l283 365 39 choices choice NNS cord-333672-ef53l283 365 40 : : : cord-333672-ef53l283 365 41 a a DT cord-333672-ef53l283 365 42 systematic systematic JJ cord-333672-ef53l283 365 43 review review NN cord-333672-ef53l283 365 44 of of IN cord-333672-ef53l283 365 45 positional positional JJ cord-333672-ef53l283 365 46 influences influence NNS cord-333672-ef53l283 365 47 on on IN cord-333672-ef53l283 365 48 food food NN cord-333672-ef53l283 365 49 choice choice NN cord-333672-ef53l283 365 50 Influences influence NNS cord-333672-ef53l283 365 51 on on IN cord-333672-ef53l283 365 52 dietary dietary JJ cord-333672-ef53l283 365 53 choices choice NNS cord-333672-ef53l283 365 54 during during IN cord-333672-ef53l283 365 55 day day NN cord-333672-ef53l283 365 56 versus versus IN cord-333672-ef53l283 365 57 night night NN cord-333672-ef53l283 365 58 shift shift NN cord-333672-ef53l283 365 59 in in IN cord-333672-ef53l283 365 60 shift shift JJ cord-333672-ef53l283 365 61 workers worker NNS cord-333672-ef53l283 365 62 : : : cord-333672-ef53l283 365 63 a a DT cord-333672-ef53l283 365 64 mixed mixed JJ cord-333672-ef53l283 365 65 methods method NNS cord-333672-ef53l283 365 66 study study NN cord-333672-ef53l283 365 67 The the DT cord-333672-ef53l283 365 68 association association NN cord-333672-ef53l283 365 69 between between IN cord-333672-ef53l283 365 70 shift shift NN cord-333672-ef53l283 365 71 duty duty NN cord-333672-ef53l283 365 72 and and CC cord-333672-ef53l283 365 73 abnormal abnormal JJ cord-333672-ef53l283 365 74 eating eat VBG cord-333672-ef53l283 365 75 behavior behavior NN cord-333672-ef53l283 365 76 among among IN cord-333672-ef53l283 365 77 nurses nurse NNS cord-333672-ef53l283 365 78 working work VBG cord-333672-ef53l283 365 79 in in IN cord-333672-ef53l283 365 80 a a DT cord-333672-ef53l283 365 81 major major JJ cord-333672-ef53l283 365 82 hospital hospital NN cord-333672-ef53l283 365 83 : : : cord-333672-ef53l283 365 84 a a DT cord-333672-ef53l283 365 85 cross cross JJ cord-333672-ef53l283 365 86 - - JJ cord-333672-ef53l283 365 87 sectional sectional JJ cord-333672-ef53l283 365 88 study study NN cord-333672-ef53l283 366 1 An an DT cord-333672-ef53l283 366 2 on on IN cord-333672-ef53l283 366 3 - - HYPH cord-333672-ef53l283 366 4 the the DT cord-333672-ef53l283 366 5 - - HYPH cord-333672-ef53l283 366 6 job job NN cord-333672-ef53l283 366 7 mindfulnessbased mindfulnessbase VBN cord-333672-ef53l283 366 8 intervention intervention NN cord-333672-ef53l283 366 9 for for IN cord-333672-ef53l283 366 10 pediatric pediatric JJ cord-333672-ef53l283 366 11 ICU ICU NNP cord-333672-ef53l283 366 12 nurses nurse NNS cord-333672-ef53l283 366 13 : : : cord-333672-ef53l283 366 14 a a DT cord-333672-ef53l283 366 15 pilot pilot NN cord-333672-ef53l283 366 16 Questionnaires questionnaire NNS cord-333672-ef53l283 366 17 that that DT cord-333672-ef53l283 366 18 screen screen NN cord-333672-ef53l283 366 19 for for IN cord-333672-ef53l283 366 20 multiple multiple JJ cord-333672-ef53l283 366 21 sleep sleep NN cord-333672-ef53l283 366 22 disorders disorder NNS cord-333672-ef53l283 366 23 Aligning align VBG cord-333672-ef53l283 366 24 work work NN cord-333672-ef53l283 366 25 and and CC cord-333672-ef53l283 366 26 circadian circadian NN cord-333672-ef53l283 366 27 time time NN cord-333672-ef53l283 366 28 in in IN cord-333672-ef53l283 366 29 shift shift NN cord-333672-ef53l283 366 30 workers worker NNS cord-333672-ef53l283 366 31 improves improve VBZ cord-333672-ef53l283 366 32 sleep sleep NN cord-333672-ef53l283 366 33 and and CC cord-333672-ef53l283 366 34 reduces reduce VBZ cord-333672-ef53l283 366 35 circadian circadian NN cord-333672-ef53l283 366 36 disruption disruption NN cord-333672-ef53l283 367 1 The the DT cord-333672-ef53l283 367 2 munich munich NNP cord-333672-ef53l283 367 3 chronotype chronotype NNP cord-333672-ef53l283 367 4 questionnaire questionnaire NN cord-333672-ef53l283 367 5 for for IN cord-333672-ef53l283 367 6 shift shift NN cord-333672-ef53l283 367 7 - - NNS cord-333672-ef53l283 367 8 workers worker NNS cord-333672-ef53l283 367 9 ( ( -LRB- cord-333672-ef53l283 367 10 MCTQShift MCTQShift NNP cord-333672-ef53l283 367 11 ) ) -RRB- cord-333672-ef53l283 367 12 Effect effect NN cord-333672-ef53l283 367 13 of of IN cord-333672-ef53l283 367 14 a a DT cord-333672-ef53l283 367 15 workplace workplace NN cord-333672-ef53l283 367 16 wellness wellness NN cord-333672-ef53l283 367 17 program program NN cord-333672-ef53l283 367 18 on on IN cord-333672-ef53l283 367 19 employee employee NN cord-333672-ef53l283 367 20 health health NN cord-333672-ef53l283 367 21 and and CC cord-333672-ef53l283 367 22 economic economic JJ cord-333672-ef53l283 367 23 outcomes outcome NNS cord-333672-ef53l283 367 24 : : : cord-333672-ef53l283 367 25 a a DT cord-333672-ef53l283 367 26 randomized randomized JJ cord-333672-ef53l283 367 27 clinical clinical JJ cord-333672-ef53l283 367 28 trial trial NN cord-333672-ef53l283 367 29 The the DT cord-333672-ef53l283 367 30 impact impact NN cord-333672-ef53l283 367 31 of of IN cord-333672-ef53l283 367 32 occupational occupational JJ cord-333672-ef53l283 367 33 shift shift NN cord-333672-ef53l283 367 34 work work NN cord-333672-ef53l283 367 35 and and CC cord-333672-ef53l283 367 36 working work VBG cord-333672-ef53l283 367 37 hours hour NNS cord-333672-ef53l283 367 38 during during IN cord-333672-ef53l283 367 39 pregnancy pregnancy NN cord-333672-ef53l283 367 40 on on IN cord-333672-ef53l283 367 41 health health NN cord-333672-ef53l283 367 42 outcomes outcome NNS cord-333672-ef53l283 367 43 : : : cord-333672-ef53l283 367 44 a a DT cord-333672-ef53l283 367 45 systematic systematic JJ cord-333672-ef53l283 367 46 review review NN cord-333672-ef53l283 367 47 and and CC cord-333672-ef53l283 367 48 meta meta NNP cord-333672-ef53l283 367 49 - - HYPH cord-333672-ef53l283 367 50 analysis analysis NN cord-333672-ef53l283 367 51 Night Night NNP cord-333672-ef53l283 367 52 shift shift NN cord-333672-ef53l283 367 53 work work NN cord-333672-ef53l283 367 54 before before IN cord-333672-ef53l283 367 55 and and CC cord-333672-ef53l283 367 56 during during IN cord-333672-ef53l283 367 57 pregnancy pregnancy NN cord-333672-ef53l283 367 58 in in IN cord-333672-ef53l283 367 59 relation relation NN cord-333672-ef53l283 367 60 to to IN cord-333672-ef53l283 367 61 depression depression NN cord-333672-ef53l283 367 62 and and CC cord-333672-ef53l283 367 63 anxiety anxiety NN cord-333672-ef53l283 367 64 in in IN cord-333672-ef53l283 367 65 adolescent adolescent JJ cord-333672-ef53l283 367 66 and and CC cord-333672-ef53l283 367 67 young young JJ cord-333672-ef53l283 367 68 adult adult NN cord-333672-ef53l283 367 69 offspring offspring NN cord-333672-ef53l283 367 70 GP gp NN cord-333672-ef53l283 368 1 conceived conceive VBD cord-333672-ef53l283 368 2 the the DT cord-333672-ef53l283 368 3 idea idea NN cord-333672-ef53l283 368 4 and and CC cord-333672-ef53l283 368 5 drafted draft VBD cord-333672-ef53l283 368 6 the the DT cord-333672-ef53l283 368 7 manuscript manuscript NN cord-333672-ef53l283 368 8 . . . cord-333672-ef53l283 369 1 TW TW NNP cord-333672-ef53l283 369 2 edited edit VBD cord-333672-ef53l283 369 3 the the DT cord-333672-ef53l283 369 4 manuscript manuscript NN cord-333672-ef53l283 369 5 and and CC cord-333672-ef53l283 369 6 produced produce VBD cord-333672-ef53l283 369 7 the the DT cord-333672-ef53l283 369 8 final final JJ cord-333672-ef53l283 369 9 draft draft NN cord-333672-ef53l283 369 10 . . . cord-333672-ef53l283 370 1 All all DT cord-333672-ef53l283 370 2 authors author NNS cord-333672-ef53l283 370 3 approved approve VBD cord-333672-ef53l283 370 4 the the DT cord-333672-ef53l283 370 5 final final JJ cord-333672-ef53l283 370 6 version version NN cord-333672-ef53l283 370 7 and and CC cord-333672-ef53l283 370 8 performed perform VBD cord-333672-ef53l283 370 9 the the DT cord-333672-ef53l283 370 10 literature literature NN cord-333672-ef53l283 370 11 review review NN cord-333672-ef53l283 370 12 . . . cord-333672-ef53l283 371 1 The the DT cord-333672-ef53l283 371 2 authors author NNS cord-333672-ef53l283 371 3 declare declare VBP cord-333672-ef53l283 371 4 that that IN cord-333672-ef53l283 371 5 the the DT cord-333672-ef53l283 371 6 research research NN cord-333672-ef53l283 371 7 was be VBD cord-333672-ef53l283 371 8 conducted conduct VBN cord-333672-ef53l283 371 9 in in IN cord-333672-ef53l283 371 10 the the DT cord-333672-ef53l283 371 11 absence absence NN cord-333672-ef53l283 371 12 of of IN cord-333672-ef53l283 371 13 any any DT cord-333672-ef53l283 371 14 commercial commercial JJ cord-333672-ef53l283 371 15 or or CC cord-333672-ef53l283 371 16 financial financial JJ cord-333672-ef53l283 371 17 relationships relationship NNS cord-333672-ef53l283 371 18 that that WDT cord-333672-ef53l283 371 19 could could MD cord-333672-ef53l283 371 20 be be VB cord-333672-ef53l283 371 21 construed construe VBN cord-333672-ef53l283 371 22 as as IN cord-333672-ef53l283 371 23 a a DT cord-333672-ef53l283 371 24 potential potential JJ cord-333672-ef53l283 371 25 conflict conflict NN cord-333672-ef53l283 371 26 of of IN cord-333672-ef53l283 371 27 interest interest NN cord-333672-ef53l283 371 28 . . . cord-333672-ef53l283 372 1 Copyright copyright NN cord-333672-ef53l283 372 2 © © NN cord-333672-ef53l283 372 3 2020 2020 CD cord-333672-ef53l283 372 4 Potter Potter NNP cord-333672-ef53l283 372 5 and and CC cord-333672-ef53l283 372 6 Wood Wood NNP cord-333672-ef53l283 372 7 . . . cord-333672-ef53l283 373 1 This this DT cord-333672-ef53l283 373 2 is be VBZ cord-333672-ef53l283 373 3 an an DT cord-333672-ef53l283 373 4 open open JJ cord-333672-ef53l283 373 5 - - HYPH cord-333672-ef53l283 373 6 access access NN cord-333672-ef53l283 373 7 article article NN cord-333672-ef53l283 373 8 distributed distribute VBN cord-333672-ef53l283 373 9 under under IN cord-333672-ef53l283 373 10 the the DT cord-333672-ef53l283 373 11 terms term NNS cord-333672-ef53l283 373 12 of of IN cord-333672-ef53l283 373 13 the the DT cord-333672-ef53l283 373 14 Creative Creative NNP cord-333672-ef53l283 373 15 Commons Commons NNP cord-333672-ef53l283 373 16 Attribution Attribution NNP cord-333672-ef53l283 373 17 License License NNP cord-333672-ef53l283 373 18 ( ( -LRB- cord-333672-ef53l283 373 19 CC CC NNP cord-333672-ef53l283 373 20 BY BY NNP cord-333672-ef53l283 373 21 ) ) -RRB- cord-333672-ef53l283 373 22 . . . cord-333672-ef53l283 374 1 The the DT cord-333672-ef53l283 374 2 use use NN cord-333672-ef53l283 374 3 , , , cord-333672-ef53l283 374 4 distribution distribution NN cord-333672-ef53l283 374 5 or or CC cord-333672-ef53l283 374 6 reproduction reproduction NN cord-333672-ef53l283 374 7 in in IN cord-333672-ef53l283 374 8 other other JJ cord-333672-ef53l283 374 9 forums forum NNS cord-333672-ef53l283 374 10 is be VBZ cord-333672-ef53l283 374 11 permitted permit VBN cord-333672-ef53l283 374 12 , , , cord-333672-ef53l283 374 13 provided provide VBD cord-333672-ef53l283 374 14 the the DT cord-333672-ef53l283 374 15 original original JJ cord-333672-ef53l283 374 16 author(s author(s NNP cord-333672-ef53l283 374 17 ) ) -RRB- cord-333672-ef53l283 374 18 and and CC cord-333672-ef53l283 374 19 the the DT cord-333672-ef53l283 374 20 copyright copyright NN cord-333672-ef53l283 374 21 owner(s owner(s NNP cord-333672-ef53l283 374 22 ) ) -RRB- cord-333672-ef53l283 374 23 are be VBP cord-333672-ef53l283 374 24 credited credit VBN cord-333672-ef53l283 374 25 and and CC cord-333672-ef53l283 374 26 that that IN cord-333672-ef53l283 374 27 the the DT cord-333672-ef53l283 374 28 original original JJ cord-333672-ef53l283 374 29 publication publication NN cord-333672-ef53l283 374 30 in in IN cord-333672-ef53l283 374 31 this this DT cord-333672-ef53l283 374 32 journal journal NN cord-333672-ef53l283 374 33 is be VBZ cord-333672-ef53l283 374 34 cited cite VBN cord-333672-ef53l283 374 35 , , , cord-333672-ef53l283 374 36 in in IN cord-333672-ef53l283 374 37 accordance accordance NN cord-333672-ef53l283 374 38 with with IN cord-333672-ef53l283 374 39 accepted accepted JJ cord-333672-ef53l283 374 40 academic academic JJ cord-333672-ef53l283 374 41 practice practice NN cord-333672-ef53l283 374 42 . . . cord-333672-ef53l283 375 1 No no DT cord-333672-ef53l283 375 2 use use NN cord-333672-ef53l283 375 3 , , , cord-333672-ef53l283 375 4 distribution distribution NN cord-333672-ef53l283 375 5 or or CC cord-333672-ef53l283 375 6 reproduction reproduction NN cord-333672-ef53l283 375 7 is be VBZ cord-333672-ef53l283 375 8 permitted permit VBN cord-333672-ef53l283 375 9 which which WDT cord-333672-ef53l283 375 10 does do VBZ cord-333672-ef53l283 375 11 not not RB cord-333672-ef53l283 375 12 comply comply VB cord-333672-ef53l283 375 13 with with IN cord-333672-ef53l283 375 14 these these DT cord-333672-ef53l283 375 15 terms term NNS cord-333672-ef53l283 375 16 . . .