id sid tid token lemma pos cord-022678-86s3u7dl 1 1 key key JJ cord-022678-86s3u7dl 1 2 : : : cord-022678-86s3u7dl 1 3 cord-022678 cord-022678 JJ cord-022678-86s3u7dl 1 4 - - HYPH cord-022678-86s3u7dl 1 5 86s3u7dl 86s3u7dl CD cord-022678-86s3u7dl 1 6 authors author NNS cord-022678-86s3u7dl 1 7 : : : cord-022678-86s3u7dl 2 1 nan nan NNP cord-022678-86s3u7dl 2 2 title title NN cord-022678-86s3u7dl 2 3 : : : cord-022678-86s3u7dl 2 4 Inaugural Inaugural NNP cord-022678-86s3u7dl 2 5 Meeting Meeting NNP cord-022678-86s3u7dl 2 6 of of IN cord-022678-86s3u7dl 2 7 the the DT cord-022678-86s3u7dl 2 8 International International NNP cord-022678-86s3u7dl 2 9 Society Society NNP cord-022678-86s3u7dl 2 10 of of IN cord-022678-86s3u7dl 2 11 Obstetric Obstetric NNP cord-022678-86s3u7dl 2 12 Medicine Medicine NNP cord-022678-86s3u7dl 2 13 : : : cord-022678-86s3u7dl 2 14 21–25 21–25 CD cord-022678-86s3u7dl 2 15 October October NNP cord-022678-86s3u7dl 2 16 2003 2003 CD cord-022678-86s3u7dl 2 17 , , , cord-022678-86s3u7dl 2 18 Fremantle Fremantle NNP cord-022678-86s3u7dl 2 19 , , , cord-022678-86s3u7dl 2 20 Western Western NNP cord-022678-86s3u7dl 2 21 AustraliaRefereed AustraliaRefereed NNP cord-022678-86s3u7dl 2 22 Abstracts abstract NNS cord-022678-86s3u7dl 2 23 of of IN cord-022678-86s3u7dl 2 24 Original Original NNP cord-022678-86s3u7dl 2 25 Oral Oral NNP cord-022678-86s3u7dl 2 26 Presentations Presentations NNPS cord-022678-86s3u7dl 2 27 at at IN cord-022678-86s3u7dl 2 28 the the DT cord-022678-86s3u7dl 2 29 Meeting Meeting NNP cord-022678-86s3u7dl 2 30 date date NN cord-022678-86s3u7dl 2 31 : : : cord-022678-86s3u7dl 2 32 2004 2004 CD cord-022678-86s3u7dl 2 33 - - HYPH cord-022678-86s3u7dl 2 34 03 03 CD cord-022678-86s3u7dl 2 35 - - HYPH cord-022678-86s3u7dl 2 36 11 11 CD cord-022678-86s3u7dl 2 37 journal journal NN cord-022678-86s3u7dl 2 38 : : : cord-022678-86s3u7dl 3 1 Aust Aust NNP cord-022678-86s3u7dl 3 2 N N NNP cord-022678-86s3u7dl 3 3 Z Z NNP cord-022678-86s3u7dl 3 4 J J NNP cord-022678-86s3u7dl 3 5 Obstet Obstet NNP cord-022678-86s3u7dl 4 1 Gynaecol Gynaecol NNP cord-022678-86s3u7dl 4 2 DOI DOI NNP cord-022678-86s3u7dl 4 3 : : : cord-022678-86s3u7dl 5 1 10.1111 10.1111 CD cord-022678-86s3u7dl 5 2 / / SYM cord-022678-86s3u7dl 5 3 j.1479 j.1479 NNP cord-022678-86s3u7dl 5 4 - - HYPH cord-022678-86s3u7dl 5 5 828x.2004.00202.x 828x.2004.00202.x CD cord-022678-86s3u7dl 5 6 sha sha NN cord-022678-86s3u7dl 5 7 : : : cord-022678-86s3u7dl 5 8 5941ab8340582597c3fd7ae5a19aa857ceda07f0 5941ab8340582597c3fd7ae5a19aa857ceda07f0 CD cord-022678-86s3u7dl 5 9 doc_id doc_id CD cord-022678-86s3u7dl 5 10 : : : cord-022678-86s3u7dl 5 11 22678 22678 CD cord-022678-86s3u7dl 5 12 cord_uid cord_uid NNS cord-022678-86s3u7dl 5 13 : : : cord-022678-86s3u7dl 5 14 86s3u7dl 86s3u7dl CD cord-022678-86s3u7dl 5 15 nan nan NNP cord-022678-86s3u7dl 6 1 The the DT cord-022678-86s3u7dl 6 2 aim aim NN cord-022678-86s3u7dl 6 3 of of IN cord-022678-86s3u7dl 6 4 this this DT cord-022678-86s3u7dl 6 5 review review NN cord-022678-86s3u7dl 6 6 was be VBD cord-022678-86s3u7dl 6 7 to to TO cord-022678-86s3u7dl 6 8 examine examine VB cord-022678-86s3u7dl 6 9 the the DT cord-022678-86s3u7dl 6 10 pregnancies pregnancy NNS cord-022678-86s3u7dl 6 11 and and CC cord-022678-86s3u7dl 6 12 their -PRON- PRP$ cord-022678-86s3u7dl 6 13 outcomes outcome NNS cord-022678-86s3u7dl 6 14 in in IN cord-022678-86s3u7dl 6 15 women woman NNS cord-022678-86s3u7dl 6 16 with with IN cord-022678-86s3u7dl 6 17 an an DT cord-022678-86s3u7dl 6 18 autoimmune autoimmune JJ cord-022678-86s3u7dl 6 19 disease disease NN cord-022678-86s3u7dl 6 20 at at IN cord-022678-86s3u7dl 6 21 Nepean Nepean NNP cord-022678-86s3u7dl 6 22 Hospital Hospital NNP cord-022678-86s3u7dl 6 23 over over IN cord-022678-86s3u7dl 6 24 the the DT cord-022678-86s3u7dl 6 25 past past JJ cord-022678-86s3u7dl 6 26 5 5 CD cord-022678-86s3u7dl 6 27 years year NNS cord-022678-86s3u7dl 6 28 and and CC cord-022678-86s3u7dl 6 29 to to TO cord-022678-86s3u7dl 6 30 compare compare VB cord-022678-86s3u7dl 6 31 these these DT cord-022678-86s3u7dl 6 32 to to IN cord-022678-86s3u7dl 6 33 the the DT cord-022678-86s3u7dl 6 34 nonautoimmune nonautoimmune NNP cord-022678-86s3u7dl 6 35 women woman NNS cord-022678-86s3u7dl 6 36 . . . cord-022678-86s3u7dl 7 1 To to TO cord-022678-86s3u7dl 7 2 achieve achieve VB cord-022678-86s3u7dl 7 3 this this DT cord-022678-86s3u7dl 7 4 , , , cord-022678-86s3u7dl 7 5 a a DT cord-022678-86s3u7dl 7 6 retrospective retrospective JJ cord-022678-86s3u7dl 7 7 review review NN cord-022678-86s3u7dl 7 8 of of IN cord-022678-86s3u7dl 7 9 the the DT cord-022678-86s3u7dl 7 10 Obstetric Obstetric NNP cord-022678-86s3u7dl 7 11 Database Database NNP cord-022678-86s3u7dl 7 12 of of IN cord-022678-86s3u7dl 7 13 all all DT cord-022678-86s3u7dl 7 14 births birth NNS cord-022678-86s3u7dl 7 15 from from IN cord-022678-86s3u7dl 7 16 1998 1998 CD cord-022678-86s3u7dl 7 17 to to IN cord-022678-86s3u7dl 7 18 2002 2002 CD cord-022678-86s3u7dl 7 19 ( ( -LRB- cord-022678-86s3u7dl 7 20 inclusive inclusive JJ cord-022678-86s3u7dl 7 21 ) ) -RRB- cord-022678-86s3u7dl 7 22 was be VBD cord-022678-86s3u7dl 7 23 performed perform VBN cord-022678-86s3u7dl 7 24 . . . cord-022678-86s3u7dl 8 1 Comparisons comparison NNS cord-022678-86s3u7dl 8 2 included include VBD cord-022678-86s3u7dl 8 3 medical medical JJ cord-022678-86s3u7dl 8 4 conditions condition NNS cord-022678-86s3u7dl 8 5 , , , cord-022678-86s3u7dl 8 6 medications medication NNS cord-022678-86s3u7dl 8 7 during during IN cord-022678-86s3u7dl 8 8 pregnancy pregnancy NN cord-022678-86s3u7dl 8 9 and and CC cord-022678-86s3u7dl 8 10 pregnancy pregnancy NN cord-022678-86s3u7dl 8 11 outcomes outcome NNS cord-022678-86s3u7dl 8 12 . . . cord-022678-86s3u7dl 9 1 Sub sub NN cord-022678-86s3u7dl 9 2 analyses analysis NNS cord-022678-86s3u7dl 9 3 were be VBD cord-022678-86s3u7dl 9 4 used use VBN cord-022678-86s3u7dl 9 5 to to TO cord-022678-86s3u7dl 9 6 explore explore VB cord-022678-86s3u7dl 9 7 differences difference NNS cord-022678-86s3u7dl 9 8 in in IN cord-022678-86s3u7dl 9 9 the the DT cord-022678-86s3u7dl 9 10 various various JJ cord-022678-86s3u7dl 9 11 autoimmune autoimmune JJ cord-022678-86s3u7dl 9 12 disease disease NN cord-022678-86s3u7dl 9 13 groups group NNS cord-022678-86s3u7dl 9 14 and and CC cord-022678-86s3u7dl 9 15 also also RB cord-022678-86s3u7dl 9 16 medication medication NN cord-022678-86s3u7dl 9 17 regimes regime NNS cord-022678-86s3u7dl 9 18 in in IN cord-022678-86s3u7dl 9 19 all all DT cord-022678-86s3u7dl 9 20 women woman NNS cord-022678-86s3u7dl 9 21 . . . cord-022678-86s3u7dl 10 1 There there EX cord-022678-86s3u7dl 10 2 were be VBD cord-022678-86s3u7dl 10 3 a a DT cord-022678-86s3u7dl 10 4 total total NN cord-022678-86s3u7dl 10 5 of of IN cord-022678-86s3u7dl 10 6 16617 16617 CD cord-022678-86s3u7dl 10 7 births birth NNS cord-022678-86s3u7dl 10 8 with with IN cord-022678-86s3u7dl 10 9 166 166 CD cord-022678-86s3u7dl 10 10 births birth NNS cord-022678-86s3u7dl 10 11 to to IN cord-022678-86s3u7dl 10 12 women woman NNS cord-022678-86s3u7dl 10 13 with with IN cord-022678-86s3u7dl 10 14 an an DT cord-022678-86s3u7dl 10 15 autoimmune autoimmune JJ cord-022678-86s3u7dl 10 16 disease disease NN cord-022678-86s3u7dl 10 17 . . . cord-022678-86s3u7dl 11 1 There there EX cord-022678-86s3u7dl 11 2 was be VBD cord-022678-86s3u7dl 11 3 a a DT cord-022678-86s3u7dl 11 4 significantly significantly RB cord-022678-86s3u7dl 11 5 higher high JJR cord-022678-86s3u7dl 11 6 incidence incidence NN cord-022678-86s3u7dl 11 7 in in IN cord-022678-86s3u7dl 11 8 autoimmune autoimmune JJ cord-022678-86s3u7dl 11 9 women woman NNS cord-022678-86s3u7dl 11 10 compared compare VBN cord-022678-86s3u7dl 11 11 to to IN cord-022678-86s3u7dl 11 12 nonautoimmune nonautoimmune NNP cord-022678-86s3u7dl 11 13 women woman NNS cord-022678-86s3u7dl 11 14 of of IN cord-022678-86s3u7dl 11 15 cardiac cardiac NNP cord-022678-86s3u7dl 11 16 ( ( -LRB- cord-022678-86s3u7dl 11 17 15 15 CD cord-022678-86s3u7dl 11 18 vs vs IN cord-022678-86s3u7dl 11 19 4 4 CD cord-022678-86s3u7dl 11 20 % % NN cord-022678-86s3u7dl 11 21 ; ; : cord-022678-86s3u7dl 11 22 P p NN cord-022678-86s3u7dl 11 23 < < XX cord-022678-86s3u7dl 11 24 0.001 0.001 CD cord-022678-86s3u7dl 11 25 ) ) -RRB- cord-022678-86s3u7dl 11 26 , , , cord-022678-86s3u7dl 11 27 valvular valvular JJ cord-022678-86s3u7dl 11 28 ( ( -LRB- cord-022678-86s3u7dl 11 29 4 4 CD cord-022678-86s3u7dl 11 30 vs vs IN cord-022678-86s3u7dl 11 31 0.5 0.5 CD cord-022678-86s3u7dl 11 32 % % NN cord-022678-86s3u7dl 11 33 ; ; : cord-022678-86s3u7dl 11 34 P p NN cord-022678-86s3u7dl 11 35 < < XX cord-022678-86s3u7dl 11 36 0.001 0.001 CD cord-022678-86s3u7dl 11 37 ) ) -RRB- cord-022678-86s3u7dl 11 38 , , , cord-022678-86s3u7dl 11 39 renal renal JJ cord-022678-86s3u7dl 11 40 ( ( -LRB- cord-022678-86s3u7dl 11 41 25 25 CD cord-022678-86s3u7dl 11 42 vs vs IN cord-022678-86s3u7dl 11 43 12 12 CD cord-022678-86s3u7dl 11 44 % % NN cord-022678-86s3u7dl 11 45 ; ; : cord-022678-86s3u7dl 11 46 P p NN cord-022678-86s3u7dl 11 47 < < XX cord-022678-86s3u7dl 11 48 0.001 0.001 CD cord-022678-86s3u7dl 11 49 ) ) -RRB- cord-022678-86s3u7dl 11 50 , , , cord-022678-86s3u7dl 11 51 haematological haematological NNP cord-022678-86s3u7dl 11 52 ( ( -LRB- cord-022678-86s3u7dl 11 53 17 17 CD cord-022678-86s3u7dl 11 54 vs vs IN cord-022678-86s3u7dl 11 55 8 8 CD cord-022678-86s3u7dl 11 56 % % NN cord-022678-86s3u7dl 11 57 ; ; : cord-022678-86s3u7dl 11 58 P p NN cord-022678-86s3u7dl 11 59 < < XX cord-022678-86s3u7dl 11 60 0.001 0.001 CD cord-022678-86s3u7dl 11 61 ) ) -RRB- cord-022678-86s3u7dl 11 62 , , , cord-022678-86s3u7dl 11 63 respiratory respiratory JJ cord-022678-86s3u7dl 11 64 ( ( -LRB- cord-022678-86s3u7dl 11 65 27 27 CD cord-022678-86s3u7dl 11 66 vs vs IN cord-022678-86s3u7dl 11 67 19 19 CD cord-022678-86s3u7dl 11 68 % % NN cord-022678-86s3u7dl 11 69 ; ; : cord-022678-86s3u7dl 11 70 P p NN cord-022678-86s3u7dl 11 71 = = SYM cord-022678-86s3u7dl 11 72 0.019 0.019 CD cord-022678-86s3u7dl 11 73 ) ) -RRB- cord-022678-86s3u7dl 11 74 , , , cord-022678-86s3u7dl 11 75 skin skin NN cord-022678-86s3u7dl 11 76 ( ( -LRB- cord-022678-86s3u7dl 11 77 17 17 CD cord-022678-86s3u7dl 11 78 vs vs IN cord-022678-86s3u7dl 11 79 10 10 CD cord-022678-86s3u7dl 11 80 % % NN cord-022678-86s3u7dl 11 81 ; ; : cord-022678-86s3u7dl 11 82 P p NN cord-022678-86s3u7dl 11 83 = = SYM cord-022678-86s3u7dl 11 84 0.006 0.006 CD cord-022678-86s3u7dl 11 85 ) ) -RRB- cord-022678-86s3u7dl 11 86 , , , cord-022678-86s3u7dl 11 87 endocrine endocrine JJ cord-022678-86s3u7dl 11 88 ( ( -LRB- cord-022678-86s3u7dl 11 89 12 12 CD cord-022678-86s3u7dl 11 90 vs vs IN cord-022678-86s3u7dl 11 91 5 5 CD cord-022678-86s3u7dl 11 92 % % NN cord-022678-86s3u7dl 11 93 ; ; : cord-022678-86s3u7dl 11 94 P p NN cord-022678-86s3u7dl 11 95 < < XX cord-022678-86s3u7dl 11 96 0.001 0.001 CD cord-022678-86s3u7dl 11 97 ) ) -RRB- cord-022678-86s3u7dl 11 98 and and CC cord-022678-86s3u7dl 11 99 hypertensive hypertensive JJ cord-022678-86s3u7dl 11 100 ( ( -LRB- cord-022678-86s3u7dl 11 101 27 27 CD cord-022678-86s3u7dl 11 102 vs vs IN cord-022678-86s3u7dl 11 103 10 10 CD cord-022678-86s3u7dl 11 104 % % NN cord-022678-86s3u7dl 11 105 ; ; : cord-022678-86s3u7dl 11 106 P p NN cord-022678-86s3u7dl 11 107 < < XX cord-022678-86s3u7dl 11 108 0.001 0.001 CD cord-022678-86s3u7dl 11 109 ) ) -RRB- cord-022678-86s3u7dl 11 110 disorders disorder NNS cord-022678-86s3u7dl 11 111 . . . cord-022678-86s3u7dl 12 1 The the DT cord-022678-86s3u7dl 12 2 major major JJ cord-022678-86s3u7dl 12 3 measure measure NN cord-022678-86s3u7dl 12 4 of of IN cord-022678-86s3u7dl 12 5 pregnancy pregnancy NN cord-022678-86s3u7dl 12 6 outcome outcome NN cord-022678-86s3u7dl 12 7 was be VBD cord-022678-86s3u7dl 12 8 the the DT cord-022678-86s3u7dl 12 9 stillbirth stillbirth NN cord-022678-86s3u7dl 12 10 rate rate NN cord-022678-86s3u7dl 12 11 which which WDT cord-022678-86s3u7dl 12 12 was be VBD cord-022678-86s3u7dl 12 13 significantly significantly RB cord-022678-86s3u7dl 12 14 higher high JJR cord-022678-86s3u7dl 12 15 ( ( -LRB- cord-022678-86s3u7dl 12 16 P p NN cord-022678-86s3u7dl 12 17 = = SYM cord-022678-86s3u7dl 12 18 0.039 0.039 CD cord-022678-86s3u7dl 12 19 ) ) -RRB- cord-022678-86s3u7dl 12 20 in in IN cord-022678-86s3u7dl 12 21 the the DT cord-022678-86s3u7dl 12 22 autoimmune autoimmune JJ cord-022678-86s3u7dl 12 23 women woman NNS cord-022678-86s3u7dl 12 24 ( ( -LRB- cord-022678-86s3u7dl 12 25 2.4 2.4 CD cord-022678-86s3u7dl 12 26 % % NN cord-022678-86s3u7dl 12 27 ) ) -RRB- cord-022678-86s3u7dl 12 28 than than IN cord-022678-86s3u7dl 12 29 in in IN cord-022678-86s3u7dl 12 30 the the DT cord-022678-86s3u7dl 12 31 nonautoimmune nonautoimmune NNP cord-022678-86s3u7dl 12 32 women woman NNS cord-022678-86s3u7dl 12 33 ( ( -LRB- cord-022678-86s3u7dl 12 34 0.9 0.9 CD cord-022678-86s3u7dl 12 35 % % NN cord-022678-86s3u7dl 12 36 ) ) -RRB- cord-022678-86s3u7dl 12 37 . . . cord-022678-86s3u7dl 13 1 This this DT cord-022678-86s3u7dl 13 2 review review NN cord-022678-86s3u7dl 13 3 confirms confirm VBZ cord-022678-86s3u7dl 13 4 the the DT cord-022678-86s3u7dl 13 5 high high JJ cord-022678-86s3u7dl 13 6 - - HYPH cord-022678-86s3u7dl 13 7 risk risk NN cord-022678-86s3u7dl 13 8 status status NN cord-022678-86s3u7dl 13 9 of of IN cord-022678-86s3u7dl 13 10 pregnant pregnant JJ cord-022678-86s3u7dl 13 11 women woman NNS cord-022678-86s3u7dl 13 12 with with IN cord-022678-86s3u7dl 13 13 an an DT cord-022678-86s3u7dl 13 14 autoimmune autoimmune JJ cord-022678-86s3u7dl 13 15 disease disease NN cord-022678-86s3u7dl 13 16 and and CC cord-022678-86s3u7dl 13 17 will will MD cord-022678-86s3u7dl 13 18 be be VB cord-022678-86s3u7dl 13 19 the the DT cord-022678-86s3u7dl 13 20 basis basis NN cord-022678-86s3u7dl 13 21 for for IN cord-022678-86s3u7dl 13 22 future future JJ cord-022678-86s3u7dl 13 23 prospective prospective JJ cord-022678-86s3u7dl 13 24 studies study NNS cord-022678-86s3u7dl 13 25 directed direct VBN cord-022678-86s3u7dl 13 26 at at IN cord-022678-86s3u7dl 13 27 those those DT cord-022678-86s3u7dl 13 28 factors factor NNS cord-022678-86s3u7dl 13 29 that that WDT cord-022678-86s3u7dl 13 30 can can MD cord-022678-86s3u7dl 13 31 be be VB cord-022678-86s3u7dl 13 32 modified modify VBN cord-022678-86s3u7dl 13 33 . . . cord-022678-86s3u7dl 14 1 The the DT cord-022678-86s3u7dl 14 2 recent recent JJ cord-022678-86s3u7dl 14 3 worldwide worldwide JJ cord-022678-86s3u7dl 14 4 outbreak outbreak NN cord-022678-86s3u7dl 14 5 of of IN cord-022678-86s3u7dl 14 6 severe severe JJ cord-022678-86s3u7dl 14 7 acute acute JJ cord-022678-86s3u7dl 14 8 respiratory respiratory JJ cord-022678-86s3u7dl 14 9 syndrome syndrome NN cord-022678-86s3u7dl 14 10 ( ( -LRB- cord-022678-86s3u7dl 14 11 SARS SARS NNP cord-022678-86s3u7dl 14 12 ) ) -RRB- cord-022678-86s3u7dl 14 13 has have VBZ cord-022678-86s3u7dl 14 14 been be VBN cord-022678-86s3u7dl 14 15 implicated implicate VBN cord-022678-86s3u7dl 14 16 in in IN cord-022678-86s3u7dl 14 17 the the DT cord-022678-86s3u7dl 14 18 development development NN cord-022678-86s3u7dl 14 19 of of IN cord-022678-86s3u7dl 14 20 a a DT cord-022678-86s3u7dl 14 21 life life NN cord-022678-86s3u7dl 14 22 - - HYPH cord-022678-86s3u7dl 14 23 threatening threaten VBG cord-022678-86s3u7dl 14 24 , , , cord-022678-86s3u7dl 14 25 atypical atypical JJ cord-022678-86s3u7dl 14 26 pneumonia pneumonia NN cord-022678-86s3u7dl 14 27 in in IN cord-022678-86s3u7dl 14 28 humans human NNS cord-022678-86s3u7dl 14 29 . . . cord-022678-86s3u7dl 15 1 Several several JJ cord-022678-86s3u7dl 15 2 cases case NNS cord-022678-86s3u7dl 15 3 have have VBP cord-022678-86s3u7dl 15 4 been be VBN cord-022678-86s3u7dl 15 5 reported report VBN cord-022678-86s3u7dl 15 6 in in IN cord-022678-86s3u7dl 15 7 pregnant pregnant JJ cord-022678-86s3u7dl 15 8 women woman NNS cord-022678-86s3u7dl 15 9 in in IN cord-022678-86s3u7dl 15 10 Hong Hong NNP cord-022678-86s3u7dl 15 11 Kong Kong NNP cord-022678-86s3u7dl 15 12 , , , cord-022678-86s3u7dl 15 13 and and CC cord-022678-86s3u7dl 15 14 isolated isolate VBN cord-022678-86s3u7dl 15 15 cases case NNS cord-022678-86s3u7dl 15 16 have have VBP cord-022678-86s3u7dl 15 17 been be VBN cord-022678-86s3u7dl 15 18 reported report VBN cord-022678-86s3u7dl 15 19 in in IN cord-022678-86s3u7dl 15 20 Singapore Singapore NNP cord-022678-86s3u7dl 15 21 and and CC cord-022678-86s3u7dl 15 22 Canada Canada NNP cord-022678-86s3u7dl 15 23 . . . cord-022678-86s3u7dl 16 1 Recent recent JJ cord-022678-86s3u7dl 16 2 microbiological microbiological JJ cord-022678-86s3u7dl 16 3 evidence evidence NN cord-022678-86s3u7dl 16 4 points point NNS cord-022678-86s3u7dl 16 5 to to IN cord-022678-86s3u7dl 16 6 a a DT cord-022678-86s3u7dl 16 7 novel novel JJ cord-022678-86s3u7dl 16 8 coronavirus coronavirus NN cord-022678-86s3u7dl 16 9 that that WDT cord-022678-86s3u7dl 16 10 is be VBZ cord-022678-86s3u7dl 16 11 spread spread VBN cord-022678-86s3u7dl 16 12 via via IN cord-022678-86s3u7dl 16 13 contact contact NN cord-022678-86s3u7dl 16 14 or or CC cord-022678-86s3u7dl 16 15 droplet droplet NN cord-022678-86s3u7dl 16 16 transmission transmission NN cord-022678-86s3u7dl 16 17 . . . cord-022678-86s3u7dl 17 1 Limited limited JJ cord-022678-86s3u7dl 17 2 data datum NNS cord-022678-86s3u7dl 17 3 are be VBP cord-022678-86s3u7dl 17 4 available available JJ cord-022678-86s3u7dl 17 5 regarding regard VBG cord-022678-86s3u7dl 17 6 the the DT cord-022678-86s3u7dl 17 7 epidemiology epidemiology NN cord-022678-86s3u7dl 17 8 and and CC cord-022678-86s3u7dl 17 9 natural natural JJ cord-022678-86s3u7dl 17 10 history history NN cord-022678-86s3u7dl 17 11 of of IN cord-022678-86s3u7dl 17 12 this this DT cord-022678-86s3u7dl 17 13 disease disease NN cord-022678-86s3u7dl 17 14 , , , cord-022678-86s3u7dl 17 15 and and CC cord-022678-86s3u7dl 17 16 there there EX cord-022678-86s3u7dl 17 17 is be VBZ cord-022678-86s3u7dl 17 18 no no DT cord-022678-86s3u7dl 17 19 published publish VBN cord-022678-86s3u7dl 17 20 information information NN cord-022678-86s3u7dl 17 21 regarding regard VBG cord-022678-86s3u7dl 17 22 the the DT cord-022678-86s3u7dl 17 23 outcomes outcome NNS cord-022678-86s3u7dl 17 24 associated associate VBN cord-022678-86s3u7dl 17 25 with with IN cord-022678-86s3u7dl 17 26 pregnancy pregnancy NN cord-022678-86s3u7dl 17 27 . . . cord-022678-86s3u7dl 18 1 Given give VBN cord-022678-86s3u7dl 18 2 the the DT cord-022678-86s3u7dl 18 3 apparent apparent JJ cord-022678-86s3u7dl 18 4 virulence virulence NN cord-022678-86s3u7dl 18 5 of of IN cord-022678-86s3u7dl 18 6 the the DT cord-022678-86s3u7dl 18 7 SARS SARS NNP cord-022678-86s3u7dl 18 8 organism organism NN cord-022678-86s3u7dl 18 9 and and CC cord-022678-86s3u7dl 18 10 the the DT cord-022678-86s3u7dl 18 11 decrease decrease NN cord-022678-86s3u7dl 18 12 in in IN cord-022678-86s3u7dl 18 13 cell cell NN cord-022678-86s3u7dl 18 14 - - HYPH cord-022678-86s3u7dl 18 15 mediated mediate VBN cord-022678-86s3u7dl 18 16 immunity immunity NN cord-022678-86s3u7dl 18 17 associated associate VBN cord-022678-86s3u7dl 18 18 with with IN cord-022678-86s3u7dl 18 19 pregnancy pregnancy NN cord-022678-86s3u7dl 18 20 , , , cord-022678-86s3u7dl 18 21 disease disease NN cord-022678-86s3u7dl 18 22 progression progression NN cord-022678-86s3u7dl 18 23 in in IN cord-022678-86s3u7dl 18 24 pregnant pregnant JJ cord-022678-86s3u7dl 18 25 women woman NNS cord-022678-86s3u7dl 18 26 may may MD cord-022678-86s3u7dl 18 27 be be VB cord-022678-86s3u7dl 18 28 comparable comparable JJ cord-022678-86s3u7dl 18 29 to to IN cord-022678-86s3u7dl 18 30 the the DT cord-022678-86s3u7dl 18 31 more more RBR cord-022678-86s3u7dl 18 32 severe severe JJ cord-022678-86s3u7dl 18 33 types type NNS cord-022678-86s3u7dl 18 34 of of IN cord-022678-86s3u7dl 18 35 viral viral JJ cord-022678-86s3u7dl 18 36 pneumonia pneumonia NN cord-022678-86s3u7dl 18 37 that that WDT cord-022678-86s3u7dl 18 38 result result VBP cord-022678-86s3u7dl 18 39 in in IN cord-022678-86s3u7dl 18 40 high high JJ cord-022678-86s3u7dl 18 41 maternal maternal JJ cord-022678-86s3u7dl 18 42 and and CC cord-022678-86s3u7dl 18 43 perinatal perinatal JJ cord-022678-86s3u7dl 18 44 morbidity morbidity NN cord-022678-86s3u7dl 18 45 and and CC cord-022678-86s3u7dl 18 46 mortality mortality NN cord-022678-86s3u7dl 18 47 rates rate NNS cord-022678-86s3u7dl 18 48 . . . cord-022678-86s3u7dl 19 1 Given give VBN cord-022678-86s3u7dl 19 2 the the DT cord-022678-86s3u7dl 19 3 significant significant JJ cord-022678-86s3u7dl 19 4 maternal maternal JJ cord-022678-86s3u7dl 19 5 and and CC cord-022678-86s3u7dl 19 6 perinatal perinatal JJ cord-022678-86s3u7dl 19 7 morbidity morbidity NN cord-022678-86s3u7dl 19 8 and and CC cord-022678-86s3u7dl 19 9 mortality mortality NN cord-022678-86s3u7dl 19 10 of of IN cord-022678-86s3u7dl 19 11 viral viral JJ cord-022678-86s3u7dl 19 12 pneumonia pneumonia NN cord-022678-86s3u7dl 19 13 in in IN cord-022678-86s3u7dl 19 14 pregnancy pregnancy NN cord-022678-86s3u7dl 19 15 , , , cord-022678-86s3u7dl 19 16 SARS SARS NNP cord-022678-86s3u7dl 19 17 may may MD cord-022678-86s3u7dl 19 18 impose impose VB cord-022678-86s3u7dl 19 19 greater great JJR cord-022678-86s3u7dl 19 20 risk risk NN cord-022678-86s3u7dl 19 21 in in IN cord-022678-86s3u7dl 19 22 pregnant pregnant JJ cord-022678-86s3u7dl 19 23 compared compare VBN cord-022678-86s3u7dl 19 24 to to IN cord-022678-86s3u7dl 19 25 non non JJ cord-022678-86s3u7dl 19 26 - - JJ cord-022678-86s3u7dl 19 27 pregnant pregnant JJ cord-022678-86s3u7dl 19 28 individuals individual NNS cord-022678-86s3u7dl 19 29 . . . cord-022678-86s3u7dl 20 1 Caring care VBG cord-022678-86s3u7dl 20 2 for for IN cord-022678-86s3u7dl 20 3 SARS SARS NNP cord-022678-86s3u7dl 20 4 - - HYPH cord-022678-86s3u7dl 20 5 affected affect VBN cord-022678-86s3u7dl 20 6 pregnant pregnant JJ cord-022678-86s3u7dl 20 7 women woman NNS cord-022678-86s3u7dl 20 8 also also RB cord-022678-86s3u7dl 20 9 poses pose VBZ cord-022678-86s3u7dl 20 10 several several JJ cord-022678-86s3u7dl 20 11 questions question NNS cord-022678-86s3u7dl 20 12 regarding regard VBG cord-022678-86s3u7dl 20 13 labour labour NN cord-022678-86s3u7dl 20 14 and and CC cord-022678-86s3u7dl 20 15 delivery delivery NN cord-022678-86s3u7dl 20 16 management management NN cord-022678-86s3u7dl 20 17 , , , cord-022678-86s3u7dl 20 18 as as RB cord-022678-86s3u7dl 20 19 well well RB cord-022678-86s3u7dl 20 20 as as IN cord-022678-86s3u7dl 20 21 the the DT cord-022678-86s3u7dl 20 22 protection protection NN cord-022678-86s3u7dl 20 23 of of IN cord-022678-86s3u7dl 20 24 health health NN cord-022678-86s3u7dl 20 25 care care NN cord-022678-86s3u7dl 20 26 providers provider NNS cord-022678-86s3u7dl 20 27 . . . cord-022678-86s3u7dl 21 1 We -PRON- PRP cord-022678-86s3u7dl 21 2 report report VBP cord-022678-86s3u7dl 21 3 outcomes outcome NNS cord-022678-86s3u7dl 21 4 of of IN cord-022678-86s3u7dl 21 5 10 10 CD cord-022678-86s3u7dl 21 6 women woman NNS cord-022678-86s3u7dl 21 7 diagnosed diagnose VBN cord-022678-86s3u7dl 21 8 with with IN cord-022678-86s3u7dl 21 9 SARS SARS NNP cord-022678-86s3u7dl 21 10 during during IN cord-022678-86s3u7dl 21 11 pregnancy pregnancy NN cord-022678-86s3u7dl 21 12 from from IN cord-022678-86s3u7dl 21 13 collaborating collaborate VBG cord-022678-86s3u7dl 21 14 centres centre NNS cord-022678-86s3u7dl 21 15 in in IN cord-022678-86s3u7dl 21 16 Canada Canada NNP cord-022678-86s3u7dl 21 17 and and CC cord-022678-86s3u7dl 21 18 Hong Hong NNP cord-022678-86s3u7dl 21 19 Kong Kong NNP cord-022678-86s3u7dl 21 20 . . . cord-022678-86s3u7dl 22 1 The the DT cord-022678-86s3u7dl 22 2 clinical clinical JJ cord-022678-86s3u7dl 22 3 presentation presentation NN cord-022678-86s3u7dl 22 4 of of IN cord-022678-86s3u7dl 22 5 SARS SARS NNP cord-022678-86s3u7dl 22 6 in in IN cord-022678-86s3u7dl 22 7 pregnant pregnant JJ cord-022678-86s3u7dl 22 8 women woman NNS cord-022678-86s3u7dl 22 9 is be VBZ cord-022678-86s3u7dl 22 10 described describe VBN cord-022678-86s3u7dl 22 11 . . . cord-022678-86s3u7dl 23 1 Sixty sixty CD cord-022678-86s3u7dl 23 2 percent percent NN cord-022678-86s3u7dl 23 3 of of IN cord-022678-86s3u7dl 23 4 pregnant pregnant JJ cord-022678-86s3u7dl 23 5 women woman NNS cord-022678-86s3u7dl 23 6 with with IN cord-022678-86s3u7dl 23 7 SARS SARS NNP cord-022678-86s3u7dl 23 8 required require VBD cord-022678-86s3u7dl 23 9 intubation intubation NN cord-022678-86s3u7dl 23 10 . . . cord-022678-86s3u7dl 24 1 Thirty thirty CD cord-022678-86s3u7dl 24 2 percent percent NN cord-022678-86s3u7dl 24 3 of of IN cord-022678-86s3u7dl 24 4 patients patient NNS cord-022678-86s3u7dl 24 5 were be VBD cord-022678-86s3u7dl 24 6 delivered deliver VBN cord-022678-86s3u7dl 24 7 preterm preterm NNS cord-022678-86s3u7dl 24 8 . . . cord-022678-86s3u7dl 25 1 The the DT cord-022678-86s3u7dl 25 2 rate rate NN cord-022678-86s3u7dl 25 3 of of IN cord-022678-86s3u7dl 25 4 Caesarean caesarean JJ cord-022678-86s3u7dl 25 5 section section NN cord-022678-86s3u7dl 25 6 was be VBD cord-022678-86s3u7dl 25 7 60 60 CD cord-022678-86s3u7dl 25 8 % % NN cord-022678-86s3u7dl 25 9 . . . cord-022678-86s3u7dl 26 1 Three three CD cord-022678-86s3u7dl 26 2 maternal maternal JJ cord-022678-86s3u7dl 26 3 deaths death NNS cord-022678-86s3u7dl 26 4 were be VBD cord-022678-86s3u7dl 26 5 reported report VBN cord-022678-86s3u7dl 26 6 . . . cord-022678-86s3u7dl 27 1 We -PRON- PRP cord-022678-86s3u7dl 27 2 also also RB cord-022678-86s3u7dl 27 3 describe describe VBP cord-022678-86s3u7dl 27 4 our -PRON- PRP$ cord-022678-86s3u7dl 27 5 centre centre NN cord-022678-86s3u7dl 27 6 's 's POS cord-022678-86s3u7dl 27 7 approach approach NN cord-022678-86s3u7dl 27 8 to to IN cord-022678-86s3u7dl 27 9 labour labour NN cord-022678-86s3u7dl 27 10 and and CC cord-022678-86s3u7dl 27 11 delivery delivery NN cord-022678-86s3u7dl 27 12 suite suite NN cord-022678-86s3u7dl 27 13 organisation organisation NN cord-022678-86s3u7dl 27 14 in in IN cord-022678-86s3u7dl 27 15 view view NN cord-022678-86s3u7dl 27 16 of of IN cord-022678-86s3u7dl 27 17 caring care VBG cord-022678-86s3u7dl 27 18 for for IN cord-022678-86s3u7dl 27 19 SARS SARS NNP cord-022678-86s3u7dl 27 20 - - HYPH cord-022678-86s3u7dl 27 21 exposed expose VBN cord-022678-86s3u7dl 27 22 and and CC cord-022678-86s3u7dl 27 23 affected affect VBN cord-022678-86s3u7dl 27 24 pregnant pregnant JJ cord-022678-86s3u7dl 27 25 individuals individual NNS cord-022678-86s3u7dl 27 26 , , , cord-022678-86s3u7dl 27 27 as as RB cord-022678-86s3u7dl 27 28 well well RB cord-022678-86s3u7dl 27 29 as as IN cord-022678-86s3u7dl 27 30 the the DT cord-022678-86s3u7dl 27 31 management management NN cord-022678-86s3u7dl 27 32 of of IN cord-022678-86s3u7dl 27 33 exposed expose VBN cord-022678-86s3u7dl 27 34 neonates neonate NNS cord-022678-86s3u7dl 27 35 . . . cord-022678-86s3u7dl 28 1 The the DT cord-022678-86s3u7dl 28 2 physiologic physiologic JJ cord-022678-86s3u7dl 28 3 adaptations adaptation NNS cord-022678-86s3u7dl 28 4 to to IN cord-022678-86s3u7dl 28 5 pregnancy pregnancy NN cord-022678-86s3u7dl 28 6 can can MD cord-022678-86s3u7dl 28 7 potentially potentially RB cord-022678-86s3u7dl 28 8 worsen worsen VB cord-022678-86s3u7dl 28 9 the the DT cord-022678-86s3u7dl 28 10 prognosis prognosis NN cord-022678-86s3u7dl 28 11 in in IN cord-022678-86s3u7dl 28 12 women woman NNS cord-022678-86s3u7dl 28 13 whose whose WP$ cord-022678-86s3u7dl 28 14 pregnancy pregnancy NN cord-022678-86s3u7dl 28 15 is be VBZ cord-022678-86s3u7dl 28 16 complicated complicate VBN cord-022678-86s3u7dl 28 17 by by IN cord-022678-86s3u7dl 28 18 heart heart NN cord-022678-86s3u7dl 28 19 disease disease NN cord-022678-86s3u7dl 28 20 . . . cord-022678-86s3u7dl 29 1 A a DT cord-022678-86s3u7dl 29 2 comprehensive comprehensive JJ cord-022678-86s3u7dl 29 3 systematic systematic JJ cord-022678-86s3u7dl 29 4 approach approach NN cord-022678-86s3u7dl 29 5 to to TO cord-022678-86s3u7dl 29 6 risk risk VB cord-022678-86s3u7dl 29 7 identification identification NN cord-022678-86s3u7dl 29 8 is be VBZ cord-022678-86s3u7dl 29 9 desirable desirable JJ cord-022678-86s3u7dl 29 10 . . . cord-022678-86s3u7dl 30 1 The the DT cord-022678-86s3u7dl 30 2 ability ability NN cord-022678-86s3u7dl 30 3 to to TO cord-022678-86s3u7dl 30 4 predict predict VB cord-022678-86s3u7dl 30 5 a a DT cord-022678-86s3u7dl 30 6 subgroup subgroup NN cord-022678-86s3u7dl 30 7 of of IN cord-022678-86s3u7dl 30 8 women woman NNS cord-022678-86s3u7dl 30 9 that that WDT cord-022678-86s3u7dl 30 10 are be VBP cord-022678-86s3u7dl 30 11 at at IN cord-022678-86s3u7dl 30 12 a a DT cord-022678-86s3u7dl 30 13 particularly particularly RB cord-022678-86s3u7dl 30 14 increased increase VBN cord-022678-86s3u7dl 30 15 risk risk NN cord-022678-86s3u7dl 30 16 of of IN cord-022678-86s3u7dl 30 17 pregnancyrelated pregnancyrelated JJ cord-022678-86s3u7dl 30 18 complications complication NNS cord-022678-86s3u7dl 30 19 can can MD cord-022678-86s3u7dl 30 20 enhance enhance VB cord-022678-86s3u7dl 30 21 the the DT cord-022678-86s3u7dl 30 22 obstetric obstetric JJ cord-022678-86s3u7dl 30 23 care care NN cord-022678-86s3u7dl 30 24 we -PRON- PRP cord-022678-86s3u7dl 30 25 provide provide VBP cord-022678-86s3u7dl 30 26 to to IN cord-022678-86s3u7dl 30 27 this this DT cord-022678-86s3u7dl 30 28 population population NN cord-022678-86s3u7dl 30 29 . . . cord-022678-86s3u7dl 31 1 A a DT cord-022678-86s3u7dl 31 2 retrospective retrospective JJ cord-022678-86s3u7dl 31 3 review review NN cord-022678-86s3u7dl 31 4 of of IN cord-022678-86s3u7dl 31 5 276 276 CD cord-022678-86s3u7dl 31 6 pregnancies pregnancy NNS cord-022678-86s3u7dl 31 7 associated associate VBN cord-022678-86s3u7dl 31 8 with with IN cord-022678-86s3u7dl 31 9 pre pre JJ cord-022678-86s3u7dl 31 10 - - JJ cord-022678-86s3u7dl 31 11 existing existing JJ cord-022678-86s3u7dl 31 12 heart heart NN cord-022678-86s3u7dl 31 13 disease disease NN cord-022678-86s3u7dl 31 14 was be VBD cord-022678-86s3u7dl 31 15 undertaken undertake VBN cord-022678-86s3u7dl 31 16 in in IN cord-022678-86s3u7dl 31 17 three three CD cord-022678-86s3u7dl 31 18 Toronto Toronto NNP cord-022678-86s3u7dl 31 19 teaching teaching NN cord-022678-86s3u7dl 31 20 institutions institution NNS cord-022678-86s3u7dl 31 21 . . . cord-022678-86s3u7dl 32 1 During during IN cord-022678-86s3u7dl 32 2 the the DT cord-022678-86s3u7dl 32 3 course course NN cord-022678-86s3u7dl 32 4 of of IN cord-022678-86s3u7dl 32 5 the the DT cord-022678-86s3u7dl 32 6 pregnancy pregnancy NN cord-022678-86s3u7dl 32 7 , , , cord-022678-86s3u7dl 32 8 45 45 CD cord-022678-86s3u7dl 32 9 ( ( -LRB- cord-022678-86s3u7dl 32 10 18 18 CD cord-022678-86s3u7dl 32 11 % % NN cord-022678-86s3u7dl 32 12 ) ) -RRB- cord-022678-86s3u7dl 32 13 out out IN cord-022678-86s3u7dl 32 14 of of IN cord-022678-86s3u7dl 32 15 252 252 CD cord-022678-86s3u7dl 32 16 completed complete VBN cord-022678-86s3u7dl 32 17 gestations gestation NNS cord-022678-86s3u7dl 32 18 were be VBD cord-022678-86s3u7dl 32 19 complicated complicate VBN cord-022678-86s3u7dl 32 20 by by IN cord-022678-86s3u7dl 32 21 adverse adverse JJ cord-022678-86s3u7dl 32 22 cardiovascular cardiovascular JJ cord-022678-86s3u7dl 32 23 events event NNS cord-022678-86s3u7dl 32 24 ( ( -LRB- cord-022678-86s3u7dl 32 25 congestive congestive JJ cord-022678-86s3u7dl 32 26 heart heart NN cord-022678-86s3u7dl 32 27 failure failure NN cord-022678-86s3u7dl 32 28 , , , cord-022678-86s3u7dl 32 29 arrhythmia arrhythmia NN cord-022678-86s3u7dl 32 30 , , , cord-022678-86s3u7dl 32 31 and and CC cord-022678-86s3u7dl 32 32 stroke stroke NN cord-022678-86s3u7dl 32 33 ) ) -RRB- cord-022678-86s3u7dl 32 34 . . . cord-022678-86s3u7dl 33 1 Poor poor JJ cord-022678-86s3u7dl 33 2 maternal maternal JJ cord-022678-86s3u7dl 33 3 functional functional JJ cord-022678-86s3u7dl 33 4 class class NN cord-022678-86s3u7dl 33 5 or or CC cord-022678-86s3u7dl 33 6 cyanosis cyanosis NN cord-022678-86s3u7dl 33 7 , , , cord-022678-86s3u7dl 33 8 myocardial myocardial JJ cord-022678-86s3u7dl 33 9 dysfunction dysfunction NN cord-022678-86s3u7dl 33 10 , , , cord-022678-86s3u7dl 33 11 left leave VBD cord-022678-86s3u7dl 33 12 heart heart NN cord-022678-86s3u7dl 33 13 obstruction obstruction NN cord-022678-86s3u7dl 33 14 , , , cord-022678-86s3u7dl 33 15 prior prior JJ cord-022678-86s3u7dl 33 16 arrhythmia arrhythmia NN cord-022678-86s3u7dl 33 17 , , , cord-022678-86s3u7dl 33 18 and and CC cord-022678-86s3u7dl 33 19 prior prior JJ cord-022678-86s3u7dl 33 20 cardiac cardiac JJ cord-022678-86s3u7dl 33 21 events event NNS cord-022678-86s3u7dl 33 22 were be VBD cord-022678-86s3u7dl 33 23 predictive predictive JJ cord-022678-86s3u7dl 33 24 of of IN cord-022678-86s3u7dl 33 25 maternal maternal JJ cord-022678-86s3u7dl 33 26 cardiac cardiac JJ cord-022678-86s3u7dl 33 27 complications complication NNS cord-022678-86s3u7dl 33 28 . . . cord-022678-86s3u7dl 34 1 These these DT cord-022678-86s3u7dl 34 2 prior prior JJ cord-022678-86s3u7dl 34 3 predictors predictor NNS cord-022678-86s3u7dl 34 4 were be VBD cord-022678-86s3u7dl 34 5 converted convert VBN cord-022678-86s3u7dl 34 6 into into IN cord-022678-86s3u7dl 34 7 a a DT cord-022678-86s3u7dl 34 8 point point NN cord-022678-86s3u7dl 34 9 score score NN cord-022678-86s3u7dl 34 10 . . . cord-022678-86s3u7dl 35 1 If if IN cord-022678-86s3u7dl 35 2 a a DT cord-022678-86s3u7dl 35 3 point point NN cord-022678-86s3u7dl 35 4 score score NN cord-022678-86s3u7dl 35 5 was be VBD cord-022678-86s3u7dl 35 6 0 0 CD cord-022678-86s3u7dl 35 7 , , , cord-022678-86s3u7dl 35 8 1 1 CD cord-022678-86s3u7dl 35 9 , , , cord-022678-86s3u7dl 35 10 or or CC cord-022678-86s3u7dl 35 11 more more JJR cord-022678-86s3u7dl 35 12 than than IN cord-022678-86s3u7dl 35 13 1 1 CD cord-022678-86s3u7dl 35 14 , , , cord-022678-86s3u7dl 35 15 the the DT cord-022678-86s3u7dl 35 16 risk risk NN cord-022678-86s3u7dl 35 17 of of IN cord-022678-86s3u7dl 35 18 a a DT cord-022678-86s3u7dl 35 19 patient patient NN cord-022678-86s3u7dl 35 20 developing develop VBG cord-022678-86s3u7dl 35 21 an an DT cord-022678-86s3u7dl 35 22 adverse adverse JJ cord-022678-86s3u7dl 35 23 cardiac cardiac JJ cord-022678-86s3u7dl 35 24 event event NN cord-022678-86s3u7dl 35 25 , , , cord-022678-86s3u7dl 35 26 was be VBD cord-022678-86s3u7dl 35 27 5 5 CD cord-022678-86s3u7dl 35 28 , , , cord-022678-86s3u7dl 35 29 27 27 CD cord-022678-86s3u7dl 35 30 , , , cord-022678-86s3u7dl 35 31 and and CC cord-022678-86s3u7dl 35 32 75 75 CD cord-022678-86s3u7dl 35 33 % % NN cord-022678-86s3u7dl 35 34 , , , cord-022678-86s3u7dl 35 35 respectively respectively RB cord-022678-86s3u7dl 35 36 . . . cord-022678-86s3u7dl 36 1 The the DT cord-022678-86s3u7dl 36 2 Canadian canadian JJ cord-022678-86s3u7dl 36 3 Prospective Prospective NNP cord-022678-86s3u7dl 36 4 Multicentre Multicentre NNP cord-022678-86s3u7dl 36 5 Study Study NNP cord-022678-86s3u7dl 36 6 allowed allow VBD cord-022678-86s3u7dl 36 7 validation validation NN cord-022678-86s3u7dl 36 8 and and CC cord-022678-86s3u7dl 36 9 simplification simplification NN cord-022678-86s3u7dl 36 10 of of IN cord-022678-86s3u7dl 36 11 this this DT cord-022678-86s3u7dl 36 12 prediction prediction NN cord-022678-86s3u7dl 36 13 rule rule NN cord-022678-86s3u7dl 36 14 . . . cord-022678-86s3u7dl 37 1 In in IN cord-022678-86s3u7dl 37 2 this this DT cord-022678-86s3u7dl 37 3 study study NN cord-022678-86s3u7dl 37 4 , , , cord-022678-86s3u7dl 37 5 13 13 CD cord-022678-86s3u7dl 37 6 centres centre NNS cord-022678-86s3u7dl 37 7 prospectively prospectively RB cord-022678-86s3u7dl 37 8 recruited recruit VBD cord-022678-86s3u7dl 37 9 599 599 CD cord-022678-86s3u7dl 37 10 patients patient NNS cord-022678-86s3u7dl 37 11 with with IN cord-022678-86s3u7dl 37 12 Australian australian JJ cord-022678-86s3u7dl 37 13 and and CC cord-022678-86s3u7dl 37 14 New New NNP cord-022678-86s3u7dl 37 15 Zealand Zealand NNP cord-022678-86s3u7dl 37 16 Journal Journal NNP cord-022678-86s3u7dl 37 17 of of IN cord-022678-86s3u7dl 37 18 Obstetrics Obstetrics NNP cord-022678-86s3u7dl 37 19 and and CC cord-022678-86s3u7dl 37 20 Gynaecology Gynaecology NNP cord-022678-86s3u7dl 37 21 2004 2004 CD cord-022678-86s3u7dl 37 22 ; ; : cord-022678-86s3u7dl 37 23 44 44 CD cord-022678-86s3u7dl 37 24 : : SYM cord-022678-86s3u7dl 37 25 177 177 CD cord-022678-86s3u7dl 37 26 -181 -181 NN cord-022678-86s3u7dl 37 27 completed complete VBN cord-022678-86s3u7dl 37 28 gestations gestation NNS cord-022678-86s3u7dl 37 29 . . . cord-022678-86s3u7dl 38 1 Similar similar JJ cord-022678-86s3u7dl 38 2 factors factor NNS cord-022678-86s3u7dl 38 3 were be VBD cord-022678-86s3u7dl 38 4 identified identify VBN cord-022678-86s3u7dl 38 5 that that IN cord-022678-86s3u7dl 38 6 predicted predict VBD cord-022678-86s3u7dl 38 7 adverse adverse JJ cord-022678-86s3u7dl 38 8 cardiac cardiac JJ cord-022678-86s3u7dl 38 9 events event NNS cord-022678-86s3u7dl 38 10 . . . cord-022678-86s3u7dl 39 1 In in IN cord-022678-86s3u7dl 39 2 addition addition NN cord-022678-86s3u7dl 39 3 neonatal neonatal JJ cord-022678-86s3u7dl 39 4 complications complication NNS cord-022678-86s3u7dl 39 5 ( ( -LRB- cord-022678-86s3u7dl 39 6 20 20 CD cord-022678-86s3u7dl 39 7 % % NN cord-022678-86s3u7dl 39 8 of of IN cord-022678-86s3u7dl 39 9 pregnancies pregnancy NNS cord-022678-86s3u7dl 39 10 ) ) -RRB- cord-022678-86s3u7dl 39 11 were be VBD cord-022678-86s3u7dl 39 12 associated associate VBN cord-022678-86s3u7dl 39 13 with with IN cord-022678-86s3u7dl 39 14 poor poor JJ cord-022678-86s3u7dl 39 15 functional functional JJ cord-022678-86s3u7dl 39 16 class class NN cord-022678-86s3u7dl 39 17 or or CC cord-022678-86s3u7dl 39 18 cyanosis cyanosis NN cord-022678-86s3u7dl 39 19 , , , cord-022678-86s3u7dl 39 20 left leave VBD cord-022678-86s3u7dl 39 21 heart heart NN cord-022678-86s3u7dl 39 22 obstruction obstruction NN cord-022678-86s3u7dl 39 23 , , , cord-022678-86s3u7dl 39 24 anticoagulation anticoagulation NN cord-022678-86s3u7dl 39 25 , , , cord-022678-86s3u7dl 39 26 smoking smoking NN cord-022678-86s3u7dl 39 27 , , , cord-022678-86s3u7dl 39 28 and and CC cord-022678-86s3u7dl 39 29 multiple multiple JJ cord-022678-86s3u7dl 39 30 gestation gestation NN cord-022678-86s3u7dl 39 31 . . . cord-022678-86s3u7dl 40 1 A a DT cord-022678-86s3u7dl 40 2 sample sample NN cord-022678-86s3u7dl 40 3 of of IN cord-022678-86s3u7dl 40 4 this this DT cord-022678-86s3u7dl 40 5 prospective prospective JJ cord-022678-86s3u7dl 40 6 cohort cohort NN cord-022678-86s3u7dl 40 7 ( ( -LRB- cord-022678-86s3u7dl 40 8 302 302 CD cord-022678-86s3u7dl 40 9 pregnancies pregnancy NNS cord-022678-86s3u7dl 40 10 ) ) -RRB- cord-022678-86s3u7dl 40 11 was be VBD cord-022678-86s3u7dl 40 12 compared compare VBN cord-022678-86s3u7dl 40 13 to to IN cord-022678-86s3u7dl 40 14 572 572 CD cord-022678-86s3u7dl 40 15 matched match VBN cord-022678-86s3u7dl 40 16 pregnancies pregnancy NNS cord-022678-86s3u7dl 40 17 with with IN cord-022678-86s3u7dl 40 18 no no DT cord-022678-86s3u7dl 40 19 underlying underlying JJ cord-022678-86s3u7dl 40 20 heart heart NN cord-022678-86s3u7dl 40 21 disease disease NN cord-022678-86s3u7dl 40 22 . . . cord-022678-86s3u7dl 41 1 The the DT cord-022678-86s3u7dl 41 2 neonatal neonatal JJ cord-022678-86s3u7dl 41 3 complication complication NN cord-022678-86s3u7dl 41 4 rate rate NN cord-022678-86s3u7dl 41 5 was be VBD cord-022678-86s3u7dl 41 6 higher high JJR cord-022678-86s3u7dl 41 7 in in IN cord-022678-86s3u7dl 41 8 the the DT cord-022678-86s3u7dl 41 9 study study NN cord-022678-86s3u7dl 41 10 group group NN cord-022678-86s3u7dl 41 11 when when WRB cord-022678-86s3u7dl 41 12 compared compare VBN cord-022678-86s3u7dl 41 13 to to IN cord-022678-86s3u7dl 41 14 controls control NNS cord-022678-86s3u7dl 41 15 , , , cord-022678-86s3u7dl 41 16 18 18 CD cord-022678-86s3u7dl 41 17 verus verus NNP cord-022678-86s3u7dl 41 18 7 7 CD cord-022678-86s3u7dl 41 19 % % NN cord-022678-86s3u7dl 41 20 , , , cord-022678-86s3u7dl 41 21 respectively respectively RB cord-022678-86s3u7dl 41 22 . . . cord-022678-86s3u7dl 42 1 The the DT cord-022678-86s3u7dl 42 2 highest high JJS cord-022678-86s3u7dl 42 3 neonatal neonatal JJ cord-022678-86s3u7dl 42 4 complication complication NN cord-022678-86s3u7dl 42 5 rate rate NN cord-022678-86s3u7dl 42 6 ( ( -LRB- cord-022678-86s3u7dl 42 7 33 33 CD cord-022678-86s3u7dl 42 8 % % NN cord-022678-86s3u7dl 42 9 ) ) -RRB- cord-022678-86s3u7dl 42 10 was be VBD cord-022678-86s3u7dl 42 11 seen see VBN cord-022678-86s3u7dl 42 12 in in IN cord-022678-86s3u7dl 42 13 gravidas gravidas NNP cord-022678-86s3u7dl 42 14 with with IN cord-022678-86s3u7dl 42 15 underlying underlie VBG cord-022678-86s3u7dl 42 16 heart heart NN cord-022678-86s3u7dl 42 17 disease disease NN cord-022678-86s3u7dl 42 18 , , , cord-022678-86s3u7dl 42 19 who who WP cord-022678-86s3u7dl 42 20 had have VBD cord-022678-86s3u7dl 42 21 previously previously RB cord-022678-86s3u7dl 42 22 identified identify VBN cord-022678-86s3u7dl 42 23 cardiac cardiac JJ cord-022678-86s3u7dl 42 24 risk risk NN cord-022678-86s3u7dl 42 25 factors factor NNS cord-022678-86s3u7dl 42 26 , , , cord-022678-86s3u7dl 42 27 who who WP cord-022678-86s3u7dl 42 28 were be VBD cord-022678-86s3u7dl 42 29 at at IN cord-022678-86s3u7dl 42 30 both both DT cord-022678-86s3u7dl 42 31 extremes extreme NNS cord-022678-86s3u7dl 42 32 of of IN cord-022678-86s3u7dl 42 33 reproductive reproductive JJ cord-022678-86s3u7dl 42 34 age age NN cord-022678-86s3u7dl 42 35 , , , cord-022678-86s3u7dl 42 36 who who WP cord-022678-86s3u7dl 42 37 had have VBD cord-022678-86s3u7dl 42 38 obstetrical obstetrical JJ cord-022678-86s3u7dl 42 39 risk risk NN cord-022678-86s3u7dl 42 40 factors factor NNS cord-022678-86s3u7dl 42 41 , , , cord-022678-86s3u7dl 42 42 who who WP cord-022678-86s3u7dl 42 43 smoked smoke VBD cord-022678-86s3u7dl 42 44 , , , cord-022678-86s3u7dl 42 45 or or CC cord-022678-86s3u7dl 42 46 who who WP cord-022678-86s3u7dl 42 47 received receive VBD cord-022678-86s3u7dl 42 48 anticoagulants anticoagulant NNS cord-022678-86s3u7dl 42 49 . . . cord-022678-86s3u7dl 43 1 Both both DT cord-022678-86s3u7dl 43 2 maternal maternal JJ cord-022678-86s3u7dl 43 3 and and CC cord-022678-86s3u7dl 43 4 neonatal neonatal JJ cord-022678-86s3u7dl 43 5 morbidity morbidity NN cord-022678-86s3u7dl 43 6 is be VBZ cord-022678-86s3u7dl 43 7 significantly significantly RB cord-022678-86s3u7dl 43 8 increased increase VBN cord-022678-86s3u7dl 43 9 in in IN cord-022678-86s3u7dl 43 10 gravidas gravidas NNP cord-022678-86s3u7dl 43 11 with with IN cord-022678-86s3u7dl 43 12 pre pre JJ cord-022678-86s3u7dl 43 13 - - JJ cord-022678-86s3u7dl 43 14 existing existing JJ cord-022678-86s3u7dl 43 15 heart heart NN cord-022678-86s3u7dl 43 16 disease disease NN cord-022678-86s3u7dl 43 17 , , , cord-022678-86s3u7dl 43 18 although although IN cord-022678-86s3u7dl 43 19 mortality mortality NN cord-022678-86s3u7dl 43 20 is be VBZ cord-022678-86s3u7dl 43 21 low low JJ cord-022678-86s3u7dl 43 22 . . . cord-022678-86s3u7dl 44 1 Factors factor NNS cord-022678-86s3u7dl 44 2 that that WDT cord-022678-86s3u7dl 44 3 place place VBP cord-022678-86s3u7dl 44 4 the the DT cord-022678-86s3u7dl 44 5 mother mother NN cord-022678-86s3u7dl 44 6 and and CC cord-022678-86s3u7dl 44 7 the the DT cord-022678-86s3u7dl 44 8 neonate neonate NN cord-022678-86s3u7dl 44 9 at at IN cord-022678-86s3u7dl 44 10 risk risk NN cord-022678-86s3u7dl 44 11 can can MD cord-022678-86s3u7dl 44 12 be be VB cord-022678-86s3u7dl 44 13 identified identify VBN cord-022678-86s3u7dl 44 14 prior prior RB cord-022678-86s3u7dl 44 15 to to IN cord-022678-86s3u7dl 44 16 pregnancy pregnancy NN cord-022678-86s3u7dl 44 17 . . . cord-022678-86s3u7dl 45 1 This this DT cord-022678-86s3u7dl 45 2 allows allow VBZ cord-022678-86s3u7dl 45 3 informed informed JJ cord-022678-86s3u7dl 45 4 counselling counselling NN cord-022678-86s3u7dl 45 5 and and CC cord-022678-86s3u7dl 45 6 development development NN cord-022678-86s3u7dl 45 7 of of IN cord-022678-86s3u7dl 45 8 patient patient NN cord-022678-86s3u7dl 45 9 - - HYPH cord-022678-86s3u7dl 45 10 specific specific JJ cord-022678-86s3u7dl 45 11 management management NN cord-022678-86s3u7dl 45 12 plan plan NN cord-022678-86s3u7dl 45 13 . . . cord-022678-86s3u7dl 46 1 To to TO cord-022678-86s3u7dl 46 2 evaluate evaluate VB cord-022678-86s3u7dl 46 3 the the DT cord-022678-86s3u7dl 46 4 maternal maternal JJ cord-022678-86s3u7dl 46 5 and and CC cord-022678-86s3u7dl 46 6 fetal fetal JJ cord-022678-86s3u7dl 46 7 outcome outcome NN cord-022678-86s3u7dl 46 8 of of IN cord-022678-86s3u7dl 46 9 pregnancies pregnancy NNS cord-022678-86s3u7dl 46 10 complicated complicate VBN cord-022678-86s3u7dl 46 11 by by IN cord-022678-86s3u7dl 46 12 cardiac cardiac JJ cord-022678-86s3u7dl 46 13 disease disease NN cord-022678-86s3u7dl 46 14 in in IN cord-022678-86s3u7dl 46 15 a a DT cord-022678-86s3u7dl 46 16 developing develop VBG cord-022678-86s3u7dl 46 17 country country NN cord-022678-86s3u7dl 46 18 , , , cord-022678-86s3u7dl 46 19 a a DT cord-022678-86s3u7dl 46 20 retrospective retrospective JJ cord-022678-86s3u7dl 46 21 analysis analysis NN cord-022678-86s3u7dl 46 22 was be VBD cord-022678-86s3u7dl 46 23 carried carry VBN cord-022678-86s3u7dl 46 24 out out IN cord-022678-86s3u7dl 46 25 of of IN cord-022678-86s3u7dl 46 26 207 207 CD cord-022678-86s3u7dl 46 27 pregnancies pregnancy NNS cord-022678-86s3u7dl 46 28 in in IN cord-022678-86s3u7dl 46 29 women woman NNS cord-022678-86s3u7dl 46 30 with with IN cord-022678-86s3u7dl 46 31 cardiac cardiac JJ cord-022678-86s3u7dl 46 32 disease disease NN cord-022678-86s3u7dl 46 33 who who WP cord-022678-86s3u7dl 46 34 delivered deliver VBD cord-022678-86s3u7dl 46 35 at at IN cord-022678-86s3u7dl 46 36 ≥28 ≥28 CD cord-022678-86s3u7dl 46 37 weeks week NNS cord-022678-86s3u7dl 46 38 of of IN cord-022678-86s3u7dl 46 39 gestation gestation NN cord-022678-86s3u7dl 46 40 from from IN cord-022678-86s3u7dl 46 41 June June NNP cord-022678-86s3u7dl 46 42 1994 1994 CD cord-022678-86s3u7dl 46 43 to to IN cord-022678-86s3u7dl 46 44 December December NNP cord-022678-86s3u7dl 46 45 2000 2000 CD cord-022678-86s3u7dl 46 46 at at IN cord-022678-86s3u7dl 46 47 a a DT cord-022678-86s3u7dl 46 48 tertiary tertiary JJ cord-022678-86s3u7dl 46 49 care care NN cord-022678-86s3u7dl 46 50 centre centre NN cord-022678-86s3u7dl 46 51 . . . cord-022678-86s3u7dl 47 1 Rheumatic rheumatic JJ cord-022678-86s3u7dl 47 2 heart heart NN cord-022678-86s3u7dl 47 3 disease disease NN cord-022678-86s3u7dl 47 4 ( ( -LRB- cord-022678-86s3u7dl 47 5 n n NN cord-022678-86s3u7dl 47 6 = = SYM cord-022678-86s3u7dl 47 7 183 183 CD cord-022678-86s3u7dl 47 8 , , , cord-022678-86s3u7dl 47 9 88 88 CD cord-022678-86s3u7dl 47 10 % % NN cord-022678-86s3u7dl 47 11 ) ) -RRB- cord-022678-86s3u7dl 47 12 with with IN cord-022678-86s3u7dl 47 13 isolated isolate VBN cord-022678-86s3u7dl 47 14 mitral mitral JJ cord-022678-86s3u7dl 47 15 stenosis stenosis NN cord-022678-86s3u7dl 47 16 ( ( -LRB- cord-022678-86s3u7dl 47 17 n n NN cord-022678-86s3u7dl 47 18 = = SYM cord-022678-86s3u7dl 47 19 71 71 CD cord-022678-86s3u7dl 47 20 ) ) -RRB- cord-022678-86s3u7dl 47 21 was be VBD cord-022678-86s3u7dl 47 22 the the DT cord-022678-86s3u7dl 47 23 predominant predominant JJ cord-022678-86s3u7dl 47 24 cardiac cardiac JJ cord-022678-86s3u7dl 47 25 problem problem NN cord-022678-86s3u7dl 47 26 . . . cord-022678-86s3u7dl 48 1 Septal Septal NNP cord-022678-86s3u7dl 48 2 defects defect NNS cord-022678-86s3u7dl 48 3 were be VBD cord-022678-86s3u7dl 48 4 the the DT cord-022678-86s3u7dl 48 5 most most RBS cord-022678-86s3u7dl 48 6 common common JJ cord-022678-86s3u7dl 48 7 form form NN cord-022678-86s3u7dl 48 8 of of IN cord-022678-86s3u7dl 48 9 congenital congenital JJ cord-022678-86s3u7dl 48 10 heart heart NN cord-022678-86s3u7dl 48 11 disease disease NN cord-022678-86s3u7dl 48 12 ( ( -LRB- cord-022678-86s3u7dl 48 13 n n NN cord-022678-86s3u7dl 48 14 = = SYM cord-022678-86s3u7dl 48 15 24 24 CD cord-022678-86s3u7dl 48 16 ) ) -RRB- cord-022678-86s3u7dl 48 17 . . . cord-022678-86s3u7dl 49 1 In in IN cord-022678-86s3u7dl 49 2 28 28 CD cord-022678-86s3u7dl 49 3 ( ( -LRB- cord-022678-86s3u7dl 49 4 13.52 13.52 CD cord-022678-86s3u7dl 49 5 % % NN cord-022678-86s3u7dl 49 6 ) ) -RRB- cord-022678-86s3u7dl 49 7 women woman NNS cord-022678-86s3u7dl 49 8 , , , cord-022678-86s3u7dl 49 9 the the DT cord-022678-86s3u7dl 49 10 diagnosis diagnosis NN cord-022678-86s3u7dl 49 11 of of IN cord-022678-86s3u7dl 49 12 cardiac cardiac JJ cord-022678-86s3u7dl 49 13 disease disease NN cord-022678-86s3u7dl 49 14 was be VBD cord-022678-86s3u7dl 49 15 made make VBN cord-022678-86s3u7dl 49 16 during during IN cord-022678-86s3u7dl 49 17 pregnancy pregnancy NN cord-022678-86s3u7dl 49 18 . . . cord-022678-86s3u7dl 50 1 Cardiac cardiac JJ cord-022678-86s3u7dl 50 2 complications complication NNS cord-022678-86s3u7dl 50 3 were be VBD cord-022678-86s3u7dl 50 4 noted note VBN cord-022678-86s3u7dl 50 5 in in IN cord-022678-86s3u7dl 50 6 62 62 CD cord-022678-86s3u7dl 50 7 ( ( -LRB- cord-022678-86s3u7dl 50 8 29.95 29.95 CD cord-022678-86s3u7dl 50 9 % % NN cord-022678-86s3u7dl 50 10 ) ) -RRB- cord-022678-86s3u7dl 50 11 and and CC cord-022678-86s3u7dl 50 12 fetal fetal JJ cord-022678-86s3u7dl 50 13 complications complication NNS cord-022678-86s3u7dl 50 14 in in IN cord-022678-86s3u7dl 50 15 42 42 CD cord-022678-86s3u7dl 50 16 ( ( -LRB- cord-022678-86s3u7dl 50 17 20.28 20.28 CD cord-022678-86s3u7dl 50 18 % % NN cord-022678-86s3u7dl 50 19 ) ) -RRB- cord-022678-86s3u7dl 50 20 pregnancies pregnancy NNS cord-022678-86s3u7dl 50 21 . . . cord-022678-86s3u7dl 51 1 Patients patient NNS cord-022678-86s3u7dl 51 2 in in IN cord-022678-86s3u7dl 51 3 New New NNP cord-022678-86s3u7dl 51 4 York York NNP cord-022678-86s3u7dl 51 5 Heart Heart NNP cord-022678-86s3u7dl 51 6 Association Association NNP cord-022678-86s3u7dl 51 7 ( ( -LRB- cord-022678-86s3u7dl 51 8 NYHA NYHA NNP cord-022678-86s3u7dl 51 9 ) ) -RRB- cord-022678-86s3u7dl 51 10 class class NN cord-022678-86s3u7dl 51 11 I I NNP cord-022678-86s3u7dl 51 12 - - HYPH cord-022678-86s3u7dl 51 13 II II NNP cord-022678-86s3u7dl 51 14 ( ( -LRB- cord-022678-86s3u7dl 51 15 n n NN cord-022678-86s3u7dl 51 16 = = SYM cord-022678-86s3u7dl 51 17 175 175 CD cord-022678-86s3u7dl 51 18 , , , cord-022678-86s3u7dl 51 19 84.54 84.54 CD cord-022678-86s3u7dl 51 20 % % NN cord-022678-86s3u7dl 51 21 ) ) -RRB- cord-022678-86s3u7dl 51 22 had have VBD cord-022678-86s3u7dl 51 23 fewer few JJR cord-022678-86s3u7dl 51 24 maternal maternal JJ cord-022678-86s3u7dl 51 25 complications complication NNS cord-022678-86s3u7dl 51 26 and and CC cord-022678-86s3u7dl 51 27 their -PRON- PRP$ cord-022678-86s3u7dl 51 28 babies baby NNS cord-022678-86s3u7dl 51 29 had have VBD cord-022678-86s3u7dl 51 30 a a DT cord-022678-86s3u7dl 51 31 higher high JJR cord-022678-86s3u7dl 51 32 birthweight birthweight NN cord-022678-86s3u7dl 51 33 than than IN cord-022678-86s3u7dl 51 34 those those DT cord-022678-86s3u7dl 51 35 in in IN cord-022678-86s3u7dl 51 36 NYHA NYHA NNP cord-022678-86s3u7dl 51 37 class class NN cord-022678-86s3u7dl 51 38 III III NNP cord-022678-86s3u7dl 51 39 - - HYPH cord-022678-86s3u7dl 51 40 IV IV NNP cord-022678-86s3u7dl 51 41 ( ( -LRB- cord-022678-86s3u7dl 51 42 n n NN cord-022678-86s3u7dl 51 43 = = SYM cord-022678-86s3u7dl 51 44 32 32 CD cord-022678-86s3u7dl 51 45 , , , cord-022678-86s3u7dl 51 46 15.45 15.45 CD cord-022678-86s3u7dl 51 47 % % NN cord-022678-86s3u7dl 51 48 ) ) -RRB- cord-022678-86s3u7dl 51 49 . . . cord-022678-86s3u7dl 52 1 Cardiac cardiac JJ cord-022678-86s3u7dl 52 2 intervention intervention NN cord-022678-86s3u7dl 52 3 was be VBD cord-022678-86s3u7dl 52 4 performed perform VBN cord-022678-86s3u7dl 52 5 prior prior RB cord-022678-86s3u7dl 52 6 to to IN cord-022678-86s3u7dl 52 7 pregnancy pregnancy NN cord-022678-86s3u7dl 52 8 in in IN cord-022678-86s3u7dl 52 9 111 111 CD cord-022678-86s3u7dl 52 10 ( ( -LRB- cord-022678-86s3u7dl 52 11 60.65 60.65 CD cord-022678-86s3u7dl 52 12 % % NN cord-022678-86s3u7dl 52 13 ) ) -RRB- cord-022678-86s3u7dl 52 14 patients patient NNS cord-022678-86s3u7dl 52 15 with with IN cord-022678-86s3u7dl 52 16 rheumatic rheumatic JJ cord-022678-86s3u7dl 52 17 heart heart NN cord-022678-86s3u7dl 52 18 disease disease NN cord-022678-86s3u7dl 52 19 : : : cord-022678-86s3u7dl 53 1 PTMC PTMC NNP cord-022678-86s3u7dl 53 2 / / SYM cord-022678-86s3u7dl 53 3 CMV CMV NNP cord-022678-86s3u7dl 53 4 in in IN cord-022678-86s3u7dl 53 5 73 73 CD cord-022678-86s3u7dl 53 6 and and CC cord-022678-86s3u7dl 53 7 valve valve NN cord-022678-86s3u7dl 53 8 replacement replacement NN cord-022678-86s3u7dl 53 9 ( ( -LRB- cord-022678-86s3u7dl 53 10 VR VR NNP cord-022678-86s3u7dl 53 11 ) ) -RRB- cord-022678-86s3u7dl 53 12 in in IN cord-022678-86s3u7dl 53 13 38 38 CD cord-022678-86s3u7dl 53 14 . . . cord-022678-86s3u7dl 54 1 Maternal maternal JJ cord-022678-86s3u7dl 54 2 and and CC cord-022678-86s3u7dl 54 3 fetal fetal JJ cord-022678-86s3u7dl 54 4 outcome outcome NN cord-022678-86s3u7dl 54 5 was be VBD cord-022678-86s3u7dl 54 6 better well JJR cord-022678-86s3u7dl 54 7 in in IN cord-022678-86s3u7dl 54 8 patients patient NNS cord-022678-86s3u7dl 54 9 with with IN cord-022678-86s3u7dl 54 10 prosthetic prosthetic JJ cord-022678-86s3u7dl 54 11 valves valve NNS cord-022678-86s3u7dl 54 12 ( ( -LRB- cord-022678-86s3u7dl 54 13 n n NN cord-022678-86s3u7dl 54 14 = = SYM cord-022678-86s3u7dl 54 15 38 38 CD cord-022678-86s3u7dl 54 16 ) ) -RRB- cord-022678-86s3u7dl 54 17 and and CC cord-022678-86s3u7dl 54 18 the the DT cord-022678-86s3u7dl 54 19 majority majority NN cord-022678-86s3u7dl 54 20 ( ( -LRB- cord-022678-86s3u7dl 54 21 97.4 97.4 CD cord-022678-86s3u7dl 54 22 % % NN cord-022678-86s3u7dl 54 23 ) ) -RRB- cord-022678-86s3u7dl 54 24 of of IN cord-022678-86s3u7dl 54 25 them -PRON- PRP cord-022678-86s3u7dl 54 26 remained remain VBD cord-022678-86s3u7dl 54 27 in in IN cord-022678-86s3u7dl 54 28 NYHA NYHA NNP cord-022678-86s3u7dl 54 29 class class NN cord-022678-86s3u7dl 54 30 I I NNP cord-022678-86s3u7dl 54 31 - - HYPH cord-022678-86s3u7dl 54 32 II II NNP cord-022678-86s3u7dl 54 33 . . . cord-022678-86s3u7dl 55 1 Cardiac cardiac JJ cord-022678-86s3u7dl 55 2 intervention intervention NN cord-022678-86s3u7dl 55 3 was be VBD cord-022678-86s3u7dl 55 4 safely safely RB cord-022678-86s3u7dl 55 5 carried carry VBN cord-022678-86s3u7dl 55 6 out out RP cord-022678-86s3u7dl 55 7 during during IN cord-022678-86s3u7dl 55 8 pregnancy pregnancy NN cord-022678-86s3u7dl 55 9 in in IN cord-022678-86s3u7dl 55 10 10 10 CD cord-022678-86s3u7dl 55 11 women woman NNS cord-022678-86s3u7dl 55 12 ( ( -LRB- cord-022678-86s3u7dl 55 13 PTMC PTMC NNP cord-022678-86s3u7dl 55 14 in in IN cord-022678-86s3u7dl 55 15 seven seven CD cord-022678-86s3u7dl 55 16 , , , cord-022678-86s3u7dl 55 17 CMV CMV NNP cord-022678-86s3u7dl 55 18 in in IN cord-022678-86s3u7dl 55 19 one one CD cord-022678-86s3u7dl 55 20 , , , cord-022678-86s3u7dl 55 21 and and CC cord-022678-86s3u7dl 55 22 VR VR NNP cord-022678-86s3u7dl 55 23 in in IN cord-022678-86s3u7dl 55 24 two two CD cord-022678-86s3u7dl 55 25 ) ) -RRB- cord-022678-86s3u7dl 55 26 . . . cord-022678-86s3u7dl 56 1 One one CD cord-022678-86s3u7dl 56 2 of of IN cord-022678-86s3u7dl 56 3 them -PRON- PRP cord-022678-86s3u7dl 56 4 developed develop VBD cord-022678-86s3u7dl 56 5 congestive congestive JJ cord-022678-86s3u7dl 56 6 cardiac cardiac JJ cord-022678-86s3u7dl 56 7 failure failure NN cord-022678-86s3u7dl 56 8 during during IN cord-022678-86s3u7dl 56 9 labour labour NN cord-022678-86s3u7dl 56 10 . . . cord-022678-86s3u7dl 57 1 None none NN cord-022678-86s3u7dl 57 2 of of IN cord-022678-86s3u7dl 57 3 the the DT cord-022678-86s3u7dl 57 4 newborns newborn NNS cord-022678-86s3u7dl 57 5 of of IN cord-022678-86s3u7dl 57 6 the the DT cord-022678-86s3u7dl 57 7 41 41 CD cord-022678-86s3u7dl 57 8 women woman NNS cord-022678-86s3u7dl 57 9 who who WP cord-022678-86s3u7dl 57 10 had have VBD cord-022678-86s3u7dl 57 11 received receive VBN cord-022678-86s3u7dl 57 12 anticoagulants anticoagulant NNS cord-022678-86s3u7dl 57 13 had have VBD cord-022678-86s3u7dl 57 14 any any DT cord-022678-86s3u7dl 57 15 congenital congenital JJ cord-022678-86s3u7dl 57 16 malformation malformation NN cord-022678-86s3u7dl 57 17 . . . cord-022678-86s3u7dl 58 1 Rheumatic rheumatic JJ cord-022678-86s3u7dl 58 2 heart heart NN cord-022678-86s3u7dl 58 3 disease disease NN cord-022678-86s3u7dl 58 4 was be VBD cord-022678-86s3u7dl 58 5 the the DT cord-022678-86s3u7dl 58 6 predominant predominant JJ cord-022678-86s3u7dl 58 7 type type NN cord-022678-86s3u7dl 58 8 . . . cord-022678-86s3u7dl 59 1 Patients patient NNS cord-022678-86s3u7dl 59 2 in in IN cord-022678-86s3u7dl 59 3 NYHA NYHA NNP cord-022678-86s3u7dl 59 4 class class NN cord-022678-86s3u7dl 59 5 I I NNP cord-022678-86s3u7dl 59 6 - - HYPH cord-022678-86s3u7dl 59 7 II II NNP cord-022678-86s3u7dl 59 8 had have VBD cord-022678-86s3u7dl 59 9 a a DT cord-022678-86s3u7dl 59 10 better well JJR cord-022678-86s3u7dl 59 11 maternal maternal JJ cord-022678-86s3u7dl 59 12 and and CC cord-022678-86s3u7dl 59 13 fetal fetal JJ cord-022678-86s3u7dl 59 14 outcome outcome NN cord-022678-86s3u7dl 59 15 than than IN cord-022678-86s3u7dl 59 16 those those DT cord-022678-86s3u7dl 59 17 in in IN cord-022678-86s3u7dl 59 18 NYHA NYHA NNP cord-022678-86s3u7dl 59 19 class class NN cord-022678-86s3u7dl 59 20 III III NNP cord-022678-86s3u7dl 59 21 - - HYPH cord-022678-86s3u7dl 59 22 IV IV NNP cord-022678-86s3u7dl 59 23 . . . cord-022678-86s3u7dl 60 1 Surgical surgical JJ cord-022678-86s3u7dl 60 2 correction correction NN cord-022678-86s3u7dl 60 3 of of IN cord-022678-86s3u7dl 60 4 the the DT cord-022678-86s3u7dl 60 5 cardiac cardiac JJ cord-022678-86s3u7dl 60 6 lesion lesion NN cord-022678-86s3u7dl 60 7 prior prior RB cord-022678-86s3u7dl 60 8 to to IN cord-022678-86s3u7dl 60 9 pregnancy pregnancy NN cord-022678-86s3u7dl 60 10 was be VBD cord-022678-86s3u7dl 60 11 associated associate VBN cord-022678-86s3u7dl 60 12 with with IN cord-022678-86s3u7dl 60 13 better well JJR cord-022678-86s3u7dl 60 14 pregnancy pregnancy NN cord-022678-86s3u7dl 60 15 outcome outcome NN cord-022678-86s3u7dl 60 16 . . . cord-022678-86s3u7dl 61 1 Pregnant pregnant JJ cord-022678-86s3u7dl 61 2 women woman NNS cord-022678-86s3u7dl 61 3 with with IN cord-022678-86s3u7dl 61 4 prosthetic prosthetic JJ cord-022678-86s3u7dl 61 5 valves valve NNS cord-022678-86s3u7dl 61 6 tolerated tolerate VBD cord-022678-86s3u7dl 61 7 pregnancy pregnancy NN cord-022678-86s3u7dl 61 8 well well RB cord-022678-86s3u7dl 61 9 . . . cord-022678-86s3u7dl 62 1 The the DT cord-022678-86s3u7dl 62 2 CHIPS chip NNS cord-022678-86s3u7dl 62 3 Trial Trial NNP cord-022678-86s3u7dl 62 4 will will MD cord-022678-86s3u7dl 62 5 determine determine VB cord-022678-86s3u7dl 62 6 if if IN cord-022678-86s3u7dl 62 7 ' ' `` cord-022678-86s3u7dl 62 8 less less RBR cord-022678-86s3u7dl 62 9 tight tight JJ cord-022678-86s3u7dl 62 10 ' ' '' cord-022678-86s3u7dl 62 11 ( ( -LRB- cord-022678-86s3u7dl 62 12 vs vs IN cord-022678-86s3u7dl 62 13 ' ' `` cord-022678-86s3u7dl 62 14 tight tight JJ cord-022678-86s3u7dl 62 15 ' ' '' cord-022678-86s3u7dl 62 16 ) ) -RRB- cord-022678-86s3u7dl 63 1 control control NN cord-022678-86s3u7dl 63 2 of of IN cord-022678-86s3u7dl 63 3 mild mild JJ cord-022678-86s3u7dl 63 4 - - HYPH cord-022678-86s3u7dl 63 5 moderate moderate JJ cord-022678-86s3u7dl 63 6 non non JJ cord-022678-86s3u7dl 63 7 - - JJ cord-022678-86s3u7dl 63 8 proteinuric proteinuric JJ cord-022678-86s3u7dl 63 9 hypertension hypertension NN cord-022678-86s3u7dl 63 10 in in IN cord-022678-86s3u7dl 63 11 pregnancy pregnancy NN cord-022678-86s3u7dl 63 12 will will MD cord-022678-86s3u7dl 63 13 decrease decrease VB cord-022678-86s3u7dl 63 14 adverse adverse JJ cord-022678-86s3u7dl 63 15 perinatal perinatal JJ cord-022678-86s3u7dl 63 16 outcome outcome NN cord-022678-86s3u7dl 63 17 without without IN cord-022678-86s3u7dl 63 18 increasing increase VBG cord-022678-86s3u7dl 63 19 maternal maternal JJ cord-022678-86s3u7dl 63 20 risk risk NN cord-022678-86s3u7dl 63 21 . . . cord-022678-86s3u7dl 64 1 First first RB cord-022678-86s3u7dl 64 2 , , , cord-022678-86s3u7dl 64 3 the the DT cord-022678-86s3u7dl 64 4 CHIPS CHIPS NNPS cord-022678-86s3u7dl 64 5 Pilot Pilot NNP cord-022678-86s3u7dl 64 6 Trial Trial NNP cord-022678-86s3u7dl 64 7 will will MD cord-022678-86s3u7dl 64 8 determine determine VB cord-022678-86s3u7dl 64 9 compliance compliance NN cord-022678-86s3u7dl 64 10 with with IN cord-022678-86s3u7dl 64 11 the the DT cord-022678-86s3u7dl 64 12 trial trial NN cord-022678-86s3u7dl 64 13 intervention intervention NN cord-022678-86s3u7dl 64 14 of of IN cord-022678-86s3u7dl 64 15 differential differential JJ cord-022678-86s3u7dl 64 16 BP BP NNP cord-022678-86s3u7dl 64 17 control control NN cord-022678-86s3u7dl 64 18 . . . cord-022678-86s3u7dl 65 1 The the DT cord-022678-86s3u7dl 65 2 CHIPS CHIPS NNPS cord-022678-86s3u7dl 65 3 Pilot Pilot NNP cord-022678-86s3u7dl 65 4 will will MD cord-022678-86s3u7dl 65 5 recruit recruit VB cord-022678-86s3u7dl 65 6 132 132 CD cord-022678-86s3u7dl 65 7 women woman NNS cord-022678-86s3u7dl 65 8 ( ( -LRB- cord-022678-86s3u7dl 65 9 66 66 CD cord-022678-86s3u7dl 65 10 per per IN cord-022678-86s3u7dl 65 11 arm arm NN cord-022678-86s3u7dl 65 12 ) ) -RRB- cord-022678-86s3u7dl 65 13 internationally internationally RB cord-022678-86s3u7dl 65 14 over over IN cord-022678-86s3u7dl 65 15 1 1 CD cord-022678-86s3u7dl 65 16 year year NN cord-022678-86s3u7dl 65 17 . . . cord-022678-86s3u7dl 66 1 Inclusion inclusion NN cord-022678-86s3u7dl 66 2 : : : cord-022678-86s3u7dl 66 3 dBP dBP `` cord-022678-86s3u7dl 66 4 90 90 CD cord-022678-86s3u7dl 66 5 - - SYM cord-022678-86s3u7dl 66 6 109 109 CD cord-022678-86s3u7dl 66 7 mmHg mmHg NNS cord-022678-86s3u7dl 66 8 due due JJ cord-022678-86s3u7dl 66 9 to to IN cord-022678-86s3u7dl 66 10 preexisting preexisting JJ cord-022678-86s3u7dl 66 11 or or CC cord-022678-86s3u7dl 66 12 gestational gestational JJ cord-022678-86s3u7dl 66 13 hypertension hypertension NN cord-022678-86s3u7dl 66 14 ; ; : cord-022678-86s3u7dl 66 15 live live JJ cord-022678-86s3u7dl 66 16 fetus(es fetus(es CD cord-022678-86s3u7dl 66 17 ) ) -RRB- cord-022678-86s3u7dl 66 18 ; ; : cord-022678-86s3u7dl 66 19 and and CC cord-022678-86s3u7dl 66 20 20 20 CD cord-022678-86s3u7dl 66 21 - - SYM cord-022678-86s3u7dl 66 22 33 33 CD cord-022678-86s3u7dl 66 23 +6 +6 CD cord-022678-86s3u7dl 66 24 week week NN cord-022678-86s3u7dl 66 25 . . . cord-022678-86s3u7dl 67 1 Exclusion exclusion NN cord-022678-86s3u7dl 67 2 : : : cord-022678-86s3u7dl 68 1 Severe severe JJ cord-022678-86s3u7dl 68 2 hypertension hypertension NN cord-022678-86s3u7dl 68 3 ; ; : cord-022678-86s3u7dl 68 4 proteinuria proteinuria NN cord-022678-86s3u7dl 68 5 ; ; : cord-022678-86s3u7dl 68 6 contraindication contraindication NN cord-022678-86s3u7dl 68 7 to to IN cord-022678-86s3u7dl 68 8 either either DT cord-022678-86s3u7dl 68 9 arm arm NN cord-022678-86s3u7dl 68 10 or or CC cord-022678-86s3u7dl 68 11 to to IN cord-022678-86s3u7dl 68 12 pregnancy pregnancy NN cord-022678-86s3u7dl 68 13 prolongation prolongation NN cord-022678-86s3u7dl 68 14 ; ; , cord-022678-86s3u7dl 68 15 or or CC cord-022678-86s3u7dl 68 16 known know VBN cord-022678-86s3u7dl 68 17 major major JJ cord-022678-86s3u7dl 68 18 fetal fetal JJ cord-022678-86s3u7dl 68 19 anomaly anomaly NN cord-022678-86s3u7dl 68 20 . . . cord-022678-86s3u7dl 69 1 Treatment treatment NN cord-022678-86s3u7dl 69 2 : : : cord-022678-86s3u7dl 70 1 Randomisation randomisation NN cord-022678-86s3u7dl 70 2 to to IN cord-022678-86s3u7dl 70 3 either either CC cord-022678-86s3u7dl 70 4 ' ' `` cord-022678-86s3u7dl 70 5 less less RBR cord-022678-86s3u7dl 70 6 tight tight JJ cord-022678-86s3u7dl 70 7 ' ' '' cord-022678-86s3u7dl 70 8 control control NN cord-022678-86s3u7dl 70 9 ( ( -LRB- cord-022678-86s3u7dl 70 10 target target NN cord-022678-86s3u7dl 71 1 dBP dBP `` cord-022678-86s3u7dl 71 2 100 100 CD cord-022678-86s3u7dl 71 3 ± ± NNP cord-022678-86s3u7dl 71 4 5 5 CD cord-022678-86s3u7dl 71 5 mmHg mmHg NNPS cord-022678-86s3u7dl 71 6 ) ) -RRB- cord-022678-86s3u7dl 71 7 or or CC cord-022678-86s3u7dl 71 8 ' ' `` cord-022678-86s3u7dl 71 9 tight tight JJ cord-022678-86s3u7dl 71 10 ' ' '' cord-022678-86s3u7dl 71 11 control control NN cord-022678-86s3u7dl 71 12 ( ( -LRB- cord-022678-86s3u7dl 71 13 target target NN cord-022678-86s3u7dl 71 14 dBP dBP '' cord-022678-86s3u7dl 71 15 85 85 CD cord-022678-86s3u7dl 71 16 ± ± NNP cord-022678-86s3u7dl 71 17 5 5 CD cord-022678-86s3u7dl 71 18 mmHg mmHg NNP cord-022678-86s3u7dl 71 19 ) ) -RRB- cord-022678-86s3u7dl 71 20 of of IN cord-022678-86s3u7dl 71 21 BP BP NNP cord-022678-86s3u7dl 71 22 . . . cord-022678-86s3u7dl 72 1 Interventions intervention NNS cord-022678-86s3u7dl 72 2 Follow follow NN cord-022678-86s3u7dl 72 3 - - HYPH cord-022678-86s3u7dl 72 4 up up NN cord-022678-86s3u7dl 72 5 : : : cord-022678-86s3u7dl 72 6 Standardised standardised JJ cord-022678-86s3u7dl 72 7 BP BP NNP cord-022678-86s3u7dl 72 8 measurement measurement NN cord-022678-86s3u7dl 72 9 . . . cord-022678-86s3u7dl 73 1 dBP dBP NNP cord-022678-86s3u7dl 73 2 and and CC cord-022678-86s3u7dl 73 3 BP BP NNP cord-022678-86s3u7dl 73 4 therapy therapy NN cord-022678-86s3u7dl 73 5 will will MD cord-022678-86s3u7dl 73 6 be be VB cord-022678-86s3u7dl 73 7 recorded record VBN cord-022678-86s3u7dl 73 8 in in IN cord-022678-86s3u7dl 73 9 a a DT cord-022678-86s3u7dl 73 10 patient patient NN cord-022678-86s3u7dl 73 11 - - HYPH cord-022678-86s3u7dl 73 12 held hold VBN cord-022678-86s3u7dl 73 13 diary diary NN cord-022678-86s3u7dl 73 14 . . . cord-022678-86s3u7dl 74 1 At at IN cord-022678-86s3u7dl 74 2 28 28 CD cord-022678-86s3u7dl 74 3 , , , cord-022678-86s3u7dl 74 4 32 32 CD cord-022678-86s3u7dl 74 5 , , , cord-022678-86s3u7dl 74 6 and and CC cord-022678-86s3u7dl 74 7 36 36 CD cord-022678-86s3u7dl 74 8 weeks week NNS cord-022678-86s3u7dl 74 9 , , , cord-022678-86s3u7dl 74 10 the the DT cord-022678-86s3u7dl 74 11 trial trial NN cord-022678-86s3u7dl 74 12 co co NNP cord-022678-86s3u7dl 74 13 - - NNP cord-022678-86s3u7dl 74 14 ordinator ordinator NNP cord-022678-86s3u7dl 74 15 will will MD cord-022678-86s3u7dl 74 16 meet meet VB cord-022678-86s3u7dl 74 17 with with IN cord-022678-86s3u7dl 74 18 women woman NNS cord-022678-86s3u7dl 74 19 to to TO cord-022678-86s3u7dl 74 20 review review VB cord-022678-86s3u7dl 74 21 the the DT cord-022678-86s3u7dl 74 22 diary diary NN cord-022678-86s3u7dl 74 23 and and CC cord-022678-86s3u7dl 74 24 BP BP NNP cord-022678-86s3u7dl 74 25 management management NN cord-022678-86s3u7dl 74 26 , , , cord-022678-86s3u7dl 74 27 and and CC cord-022678-86s3u7dl 74 28 have have VBP cord-022678-86s3u7dl 74 29 dBP dBP VBN cord-022678-86s3u7dl 74 30 measured measure VBN cord-022678-86s3u7dl 74 31 independently independently RB cord-022678-86s3u7dl 74 32 . . . cord-022678-86s3u7dl 75 1 Other other JJ cord-022678-86s3u7dl 75 2 outcomes outcome NNS cord-022678-86s3u7dl 75 3 will will MD cord-022678-86s3u7dl 75 4 be be VB cord-022678-86s3u7dl 75 5 assessed assess VBN cord-022678-86s3u7dl 75 6 during during IN cord-022678-86s3u7dl 75 7 delivery delivery NN cord-022678-86s3u7dl 75 8 admission admission NN cord-022678-86s3u7dl 75 9 when when WRB cord-022678-86s3u7dl 75 10 women woman NNS cord-022678-86s3u7dl 75 11 will will MD cord-022678-86s3u7dl 75 12 complete complete VB cord-022678-86s3u7dl 75 13 a a DT cord-022678-86s3u7dl 75 14 questionnaire questionnaire NN cord-022678-86s3u7dl 75 15 about about IN cord-022678-86s3u7dl 75 16 their -PRON- PRP$ cord-022678-86s3u7dl 75 17 views view NNS cord-022678-86s3u7dl 75 18 . . . cord-022678-86s3u7dl 76 1 CIHR CIHR NNP cord-022678-86s3u7dl 76 2 funded fund VBN cord-022678-86s3u7dl 76 3 . . . cord-022678-86s3u7dl 77 1 Recruitment recruitment NN cord-022678-86s3u7dl 77 2 from from IN cord-022678-86s3u7dl 77 3 Apr/03 Apr/03 NNP cord-022678-86s3u7dl 77 4 . . . cord-022678-86s3u7dl 78 1 Interested interested JJ cord-022678-86s3u7dl 78 2 centres centre NNS cord-022678-86s3u7dl 78 3 should should MD cord-022678-86s3u7dl 78 4 contact contact VB cord-022678-86s3u7dl 78 5 L L NNP cord-022678-86s3u7dl 78 6 Magee Magee NNP cord-022678-86s3u7dl 78 7 ( ( -LRB- cord-022678-86s3u7dl 78 8 LMagee@cw.bc.ca LMagee@cw.bc.ca NNP cord-022678-86s3u7dl 78 9 ) ) -RRB- cord-022678-86s3u7dl 78 10 for for IN cord-022678-86s3u7dl 78 11 CHIPS CHIPS NNP cord-022678-86s3u7dl 78 12 Study Study NNP cord-022678-86s3u7dl 78 13 Group Group NNP cord-022678-86s3u7dl 78 14 . . . cord-022678-86s3u7dl 79 1 Maternal maternal JJ cord-022678-86s3u7dl 79 2 pulse pulse NN cord-022678-86s3u7dl 79 3 pressure pressure NN cord-022678-86s3u7dl 79 4 in in IN cord-022678-86s3u7dl 79 5 severe severe JJ cord-022678-86s3u7dl 79 6 early early JJ cord-022678-86s3u7dl 79 7 onset onset NN cord-022678-86s3u7dl 79 8 pre pre JJ cord-022678-86s3u7dl 79 9 - - JJ cord-022678-86s3u7dl 79 10 eclampsia eclampsia JJ cord-022678-86s3u7dl 79 11 STEYN STEYN NNP cord-022678-86s3u7dl 79 12 W W NNP cord-022678-86s3u7dl 79 13 Assessment Assessment NNP cord-022678-86s3u7dl 79 14 and and CC cord-022678-86s3u7dl 79 15 management management NN cord-022678-86s3u7dl 79 16 of of IN cord-022678-86s3u7dl 79 17 hypertension hypertension NN cord-022678-86s3u7dl 79 18 in in IN cord-022678-86s3u7dl 79 19 pregnancy pregnancy NN cord-022678-86s3u7dl 79 20 depend depend VBP cord-022678-86s3u7dl 79 21 on on IN cord-022678-86s3u7dl 79 22 systolic systolic JJ cord-022678-86s3u7dl 79 23 blood blood NN cord-022678-86s3u7dl 79 24 pressure pressure NN cord-022678-86s3u7dl 79 25 ( ( -LRB- cord-022678-86s3u7dl 79 26 SBP SBP NNP cord-022678-86s3u7dl 79 27 ) ) -RRB- cord-022678-86s3u7dl 79 28 and and CC cord-022678-86s3u7dl 79 29 diastolic diastolic JJ cord-022678-86s3u7dl 79 30 blood blood NN cord-022678-86s3u7dl 79 31 pressure pressure NN cord-022678-86s3u7dl 79 32 ( ( -LRB- cord-022678-86s3u7dl 79 33 DBP DBP NNP cord-022678-86s3u7dl 79 34 ) ) -RRB- cord-022678-86s3u7dl 79 35 . . . cord-022678-86s3u7dl 80 1 Relatively relatively RB cord-022678-86s3u7dl 80 2 little little JJ cord-022678-86s3u7dl 80 3 has have VBZ cord-022678-86s3u7dl 80 4 been be VBN cord-022678-86s3u7dl 80 5 published publish VBN cord-022678-86s3u7dl 80 6 about about IN cord-022678-86s3u7dl 80 7 pulse pulse NN cord-022678-86s3u7dl 80 8 pressure pressure NN cord-022678-86s3u7dl 80 9 . . . cord-022678-86s3u7dl 81 1 We -PRON- PRP cord-022678-86s3u7dl 81 2 assessed assess VBD cord-022678-86s3u7dl 81 3 the the DT cord-022678-86s3u7dl 81 4 characteristics characteristic NNS cord-022678-86s3u7dl 81 5 of of IN cord-022678-86s3u7dl 81 6 maternal maternal JJ cord-022678-86s3u7dl 81 7 pulse pulse NN cord-022678-86s3u7dl 81 8 pressure pressure NN cord-022678-86s3u7dl 81 9 ( ( -LRB- cord-022678-86s3u7dl 81 10 PP PP NNP cord-022678-86s3u7dl 81 11 ) ) -RRB- cord-022678-86s3u7dl 81 12 in in IN cord-022678-86s3u7dl 81 13 severe severe JJ cord-022678-86s3u7dl 81 14 early early JJ cord-022678-86s3u7dl 81 15 onset onset NN cord-022678-86s3u7dl 81 16 pre pre JJ cord-022678-86s3u7dl 81 17 - - JJ cord-022678-86s3u7dl 81 18 eclampsia eclampsia JJ cord-022678-86s3u7dl 81 19 ( ( -LRB- cord-022678-86s3u7dl 81 20 PE PE NNP cord-022678-86s3u7dl 81 21 ) ) -RRB- cord-022678-86s3u7dl 81 22 . . . cord-022678-86s3u7dl 82 1 Blood blood NN cord-022678-86s3u7dl 82 2 pressure pressure NN cord-022678-86s3u7dl 82 3 in in IN cord-022678-86s3u7dl 82 4 mothers mother NNS cord-022678-86s3u7dl 82 5 with with IN cord-022678-86s3u7dl 82 6 severe severe JJ cord-022678-86s3u7dl 82 7 PE pe NN cord-022678-86s3u7dl 82 8 before before RB cord-022678-86s3u7dl 82 9 34 34 CD cord-022678-86s3u7dl 82 10 weeks week NNS cord-022678-86s3u7dl 82 11 ' ' POS cord-022678-86s3u7dl 82 12 gestation gestation NN cord-022678-86s3u7dl 82 13 who who WP cord-022678-86s3u7dl 82 14 were be VBD cord-022678-86s3u7dl 82 15 managed manage VBN cord-022678-86s3u7dl 82 16 expectantly expectantly RB cord-022678-86s3u7dl 82 17 was be VBD cord-022678-86s3u7dl 82 18 also also RB cord-022678-86s3u7dl 82 19 measured measure VBN cord-022678-86s3u7dl 82 20 every every DT cord-022678-86s3u7dl 82 21 30 30 CD cord-022678-86s3u7dl 82 22 min min NN cord-022678-86s3u7dl 82 23 on on IN cord-022678-86s3u7dl 82 24 alternative alternative JJ cord-022678-86s3u7dl 82 25 days day NNS cord-022678-86s3u7dl 82 26 with with IN cord-022678-86s3u7dl 82 27 the the DT cord-022678-86s3u7dl 82 28 pregnancy pregnancy NN cord-022678-86s3u7dl 82 29 validated validate VBD cord-022678-86s3u7dl 82 30 Spacelabs Spacelabs NNP cord-022678-86s3u7dl 82 31 90207 90207 CD cord-022678-86s3u7dl 82 32 ambulatory ambulatory JJ cord-022678-86s3u7dl 82 33 monitor monitor NN cord-022678-86s3u7dl 82 34 . . . cord-022678-86s3u7dl 83 1 These these DT cord-022678-86s3u7dl 83 2 results result NNS cord-022678-86s3u7dl 83 3 were be VBD cord-022678-86s3u7dl 83 4 not not RB cord-022678-86s3u7dl 83 5 available available JJ cord-022678-86s3u7dl 83 6 to to IN cord-022678-86s3u7dl 83 7 managing manage VBG cord-022678-86s3u7dl 83 8 clinicians clinician NNS cord-022678-86s3u7dl 83 9 . . . cord-022678-86s3u7dl 84 1 Women woman NNS cord-022678-86s3u7dl 84 2 were be VBD cord-022678-86s3u7dl 84 3 managed manage VBN cord-022678-86s3u7dl 84 4 according accord VBG cord-022678-86s3u7dl 84 5 to to IN cord-022678-86s3u7dl 84 6 departmental departmental JJ cord-022678-86s3u7dl 84 7 policy policy NN cord-022678-86s3u7dl 84 8 . . . cord-022678-86s3u7dl 85 1 The the DT cord-022678-86s3u7dl 85 2 mean mean JJ cord-022678-86s3u7dl 85 3 PP PP NNP cord-022678-86s3u7dl 85 4 of of IN cord-022678-86s3u7dl 85 5 19196 19196 CD cord-022678-86s3u7dl 85 6 measurements measurement NNS cord-022678-86s3u7dl 85 7 obtained obtain VBN cord-022678-86s3u7dl 85 8 from from IN cord-022678-86s3u7dl 85 9 87 87 CD cord-022678-86s3u7dl 85 10 women woman NNS cord-022678-86s3u7dl 85 11 was be VBD cord-022678-86s3u7dl 85 12 52.1 52.1 CD cord-022678-86s3u7dl 85 13 ± ± CD cord-022678-86s3u7dl 85 14 11.1 11.1 CD cord-022678-86s3u7dl 85 15 mmHg mmHg NNS cord-022678-86s3u7dl 85 16 . . . cord-022678-86s3u7dl 86 1 The the DT cord-022678-86s3u7dl 86 2 PP PP NNP cord-022678-86s3u7dl 86 3 correlated correlate VBD cord-022678-86s3u7dl 86 4 significantly significantly RB cord-022678-86s3u7dl 86 5 with with IN cord-022678-86s3u7dl 86 6 the the DT cord-022678-86s3u7dl 86 7 SBP SBP NNP cord-022678-86s3u7dl 86 8 ( ( -LRB- cord-022678-86s3u7dl 86 9 r r NN cord-022678-86s3u7dl 86 10 = = SYM cord-022678-86s3u7dl 86 11 0.894 0.894 NN cord-022678-86s3u7dl 86 12 ; ; : cord-022678-86s3u7dl 86 13 P p NN cord-022678-86s3u7dl 86 14 < < XX cord-022678-86s3u7dl 86 15 0.001 0.001 CD cord-022678-86s3u7dl 86 16 ) ) -RRB- cord-022678-86s3u7dl 86 17 , , , cord-022678-86s3u7dl 86 18 the the DT cord-022678-86s3u7dl 86 19 DBP dbp NN cord-022678-86s3u7dl 86 20 ( ( -LRB- cord-022678-86s3u7dl 86 21 r r NN cord-022678-86s3u7dl 86 22 = = SYM cord-022678-86s3u7dl 86 23 −0.116 −0.116 UH cord-022678-86s3u7dl 86 24 , , , cord-022678-86s3u7dl 86 25 P p NN cord-022678-86s3u7dl 86 26 < < XX cord-022678-86s3u7dl 86 27 0.001 0.001 CD cord-022678-86s3u7dl 86 28 ) ) -RRB- cord-022678-86s3u7dl 86 29 and and CC cord-022678-86s3u7dl 86 30 the the DT cord-022678-86s3u7dl 86 31 mean mean JJ cord-022678-86s3u7dl 86 32 arterial arterial JJ cord-022678-86s3u7dl 86 33 pressure pressure NN cord-022678-86s3u7dl 86 34 ( ( -LRB- cord-022678-86s3u7dl 86 35 MAP MAP NNP cord-022678-86s3u7dl 86 36 ) ) -RRB- cord-022678-86s3u7dl 87 1 ( ( -LRB- cord-022678-86s3u7dl 87 2 r r NN cord-022678-86s3u7dl 87 3 = = SYM cord-022678-86s3u7dl 87 4 0.165 0.165 CD cord-022678-86s3u7dl 87 5 , , , cord-022678-86s3u7dl 87 6 P p NN cord-022678-86s3u7dl 87 7 < < XX cord-022678-86s3u7dl 87 8 0.001 0.001 CD cord-022678-86s3u7dl 87 9 ) ) -RRB- cord-022678-86s3u7dl 87 10 . . . cord-022678-86s3u7dl 88 1 This this DT cord-022678-86s3u7dl 88 2 correlation correlation NN cord-022678-86s3u7dl 88 3 between between IN cord-022678-86s3u7dl 88 4 PP PP NNP cord-022678-86s3u7dl 88 5 and and CC cord-022678-86s3u7dl 88 6 SBP SBP NNP cord-022678-86s3u7dl 88 7 remained remain VBD cord-022678-86s3u7dl 88 8 significant significant JJ cord-022678-86s3u7dl 88 9 for for IN cord-022678-86s3u7dl 88 10 all all DT cord-022678-86s3u7dl 88 11 PP PP NNP cord-022678-86s3u7dl 88 12 values value NNS cord-022678-86s3u7dl 88 13 . . . cord-022678-86s3u7dl 89 1 The the DT cord-022678-86s3u7dl 89 2 correlation correlation NN cord-022678-86s3u7dl 89 3 between between IN cord-022678-86s3u7dl 89 4 PP PP NNP cord-022678-86s3u7dl 89 5 and and CC cord-022678-86s3u7dl 89 6 DBP DBP NNP cord-022678-86s3u7dl 89 7 was be VBD cord-022678-86s3u7dl 89 8 not not RB cord-022678-86s3u7dl 89 9 significant significant JJ cord-022678-86s3u7dl 89 10 when when WRB cord-022678-86s3u7dl 89 11 only only RB cord-022678-86s3u7dl 89 12 the the DT cord-022678-86s3u7dl 89 13 upper upper JJ cord-022678-86s3u7dl 89 14 quartile quartile NN cord-022678-86s3u7dl 89 15 of of IN cord-022678-86s3u7dl 89 16 PP PP NNP cord-022678-86s3u7dl 89 17 was be VBD cord-022678-86s3u7dl 89 18 considered consider VBN cord-022678-86s3u7dl 89 19 . . . cord-022678-86s3u7dl 90 1 PP PP NNP cord-022678-86s3u7dl 90 2 was be VBD cord-022678-86s3u7dl 90 3 also also RB cord-022678-86s3u7dl 90 4 significantly significantly RB cord-022678-86s3u7dl 90 5 influenced influence VBN cord-022678-86s3u7dl 90 6 by by IN cord-022678-86s3u7dl 90 7 parity parity NN cord-022678-86s3u7dl 90 8 ( ( -LRB- cord-022678-86s3u7dl 90 9 multipara multipara NNP cord-022678-86s3u7dl 90 10 = = SYM cord-022678-86s3u7dl 90 11 50.6 50.6 CD cord-022678-86s3u7dl 90 12 mmHg mmHg NNS cord-022678-86s3u7dl 90 13 ; ; : cord-022678-86s3u7dl 90 14 primipara primipara NNP cord-022678-86s3u7dl 90 15 = = SYM cord-022678-86s3u7dl 90 16 47.8 47.8 CD cord-022678-86s3u7dl 90 17 mmHg mmHg NNPS cord-022678-86s3u7dl 90 18 , , , cord-022678-86s3u7dl 90 19 P p NN cord-022678-86s3u7dl 90 20 < < XX cord-022678-86s3u7dl 90 21 0.001 0.001 CD cord-022678-86s3u7dl 90 22 ) ) -RRB- cord-022678-86s3u7dl 90 23 , , , cord-022678-86s3u7dl 90 24 medication medication NN cord-022678-86s3u7dl 90 25 used use VBN cord-022678-86s3u7dl 90 26 and and CC cord-022678-86s3u7dl 90 27 gestational gestational JJ cord-022678-86s3u7dl 90 28 age age NN cord-022678-86s3u7dl 90 29 ( ( -LRB- cord-022678-86s3u7dl 90 30 GA GA NNP cord-022678-86s3u7dl 90 31 ) ) -RRB- cord-022678-86s3u7dl 91 1 ( ( -LRB- cord-022678-86s3u7dl 91 2 GA GA NNP cord-022678-86s3u7dl 91 3 28 28 CD cord-022678-86s3u7dl 91 4 - - SYM cord-022678-86s3u7dl 91 5 31 31 CD cord-022678-86s3u7dl 91 6 weeks week NNS cord-022678-86s3u7dl 91 7 = = SYM cord-022678-86s3u7dl 91 8 53.7 53.7 CD cord-022678-86s3u7dl 91 9 mmHg mmHg NNS cord-022678-86s3u7dl 91 10 ; ; : cord-022678-86s3u7dl 91 11 GA GA NNP cord-022678-86s3u7dl 91 12 32 32 CD cord-022678-86s3u7dl 91 13 - - SYM cord-022678-86s3u7dl 91 14 34 34 CD cord-022678-86s3u7dl 91 15 weeks week NNS cord-022678-86s3u7dl 91 16 = = SYM cord-022678-86s3u7dl 91 17 52.6 52.6 CD cord-022678-86s3u7dl 91 18 mmHg mmHg NNS cord-022678-86s3u7dl 91 19 , , , cord-022678-86s3u7dl 91 20 P p NN cord-022678-86s3u7dl 91 21 < < XX cord-022678-86s3u7dl 91 22 0.001 0.001 CD cord-022678-86s3u7dl 91 23 ) ) -RRB- cord-022678-86s3u7dl 91 24 . . . cord-022678-86s3u7dl 92 1 The the DT cord-022678-86s3u7dl 92 2 mean mean JJ cord-022678-86s3u7dl 92 3 PP PP NNP cord-022678-86s3u7dl 92 4 was be VBD cord-022678-86s3u7dl 92 5 higher high JJR cord-022678-86s3u7dl 92 6 at at IN cord-022678-86s3u7dl 92 7 night night NN cord-022678-86s3u7dl 92 8 ( ( -LRB- cord-022678-86s3u7dl 92 9 55.1 55.1 CD cord-022678-86s3u7dl 92 10 ± ± NNP cord-022678-86s3u7dl 92 11 2.0 2.0 CD cord-022678-86s3u7dl 92 12 vs vs IN cord-022678-86s3u7dl 92 13 52.9 52.9 CD cord-022678-86s3u7dl 92 14 ± ± NNP cord-022678-86s3u7dl 92 15 11.0 11.0 CD cord-022678-86s3u7dl 92 16 ; ; : cord-022678-86s3u7dl 92 17 P p NN cord-022678-86s3u7dl 92 18 < < XX cord-022678-86s3u7dl 92 19 0.001 0.001 CD cord-022678-86s3u7dl 92 20 ) ) -RRB- cord-022678-86s3u7dl 92 21 . . . cord-022678-86s3u7dl 93 1 Mean mean JJ cord-022678-86s3u7dl 93 2 SBP SBP NNP cord-022678-86s3u7dl 93 3 and and CC cord-022678-86s3u7dl 93 4 mean mean VB cord-022678-86s3u7dl 93 5 MAP MAP NNP cord-022678-86s3u7dl 93 6 were be VBD cord-022678-86s3u7dl 93 7 significantly significantly RB cord-022678-86s3u7dl 93 8 higher high JJR cord-022678-86s3u7dl 93 9 in in IN cord-022678-86s3u7dl 93 10 the the DT cord-022678-86s3u7dl 93 11 upper upper JJ cord-022678-86s3u7dl 93 12 quartile quartile NN cord-022678-86s3u7dl 93 13 of of IN cord-022678-86s3u7dl 93 14 PP PP NNP cord-022678-86s3u7dl 93 15 compared compare VBN cord-022678-86s3u7dl 93 16 with with IN cord-022678-86s3u7dl 93 17 the the DT cord-022678-86s3u7dl 93 18 lower low JJR cord-022678-86s3u7dl 93 19 quartile quartile NN cord-022678-86s3u7dl 93 20 ( ( -LRB- cord-022678-86s3u7dl 93 21 148.7 148.7 CD cord-022678-86s3u7dl 93 22 vs vs IN cord-022678-86s3u7dl 93 23 127.3 127.3 CD cord-022678-86s3u7dl 93 24 mmHg mmHg NNS cord-022678-86s3u7dl 93 25 and and CC cord-022678-86s3u7dl 93 26 106.3 106.3 CD cord-022678-86s3u7dl 93 27 vs vs IN cord-022678-86s3u7dl 93 28 101.3 101.3 CD cord-022678-86s3u7dl 93 29 mmHg mmHg NNS cord-022678-86s3u7dl 93 30 , , , cord-022678-86s3u7dl 93 31 respectively respectively RB cord-022678-86s3u7dl 93 32 ) ) -RRB- cord-022678-86s3u7dl 93 33 , , , cord-022678-86s3u7dl 93 34 while while IN cord-022678-86s3u7dl 93 35 DBP DBP NNP cord-022678-86s3u7dl 93 36 decreased decrease VBD cord-022678-86s3u7dl 93 37 ( ( -LRB- cord-022678-86s3u7dl 93 38 82.5 82.5 CD cord-022678-86s3u7dl 93 39 mmHg mmHg NNS cord-022678-86s3u7dl 93 40 vs vs IN cord-022678-86s3u7dl 93 41 87.5 87.5 CD cord-022678-86s3u7dl 93 42 mmHg mmHg NNPS cord-022678-86s3u7dl 93 43 ) ) -RRB- cord-022678-86s3u7dl 93 44 . . . cord-022678-86s3u7dl 94 1 Pulse pulse NN cord-022678-86s3u7dl 94 2 pressure pressure NN cord-022678-86s3u7dl 94 3 changes change NNS cord-022678-86s3u7dl 94 4 in in IN cord-022678-86s3u7dl 94 5 women woman NNS cord-022678-86s3u7dl 94 6 with with IN cord-022678-86s3u7dl 94 7 severe severe JJ cord-022678-86s3u7dl 94 8 pre pre JJ cord-022678-86s3u7dl 94 9 - - NN cord-022678-86s3u7dl 94 10 eclampsia eclampsia JJ cord-022678-86s3u7dl 94 11 are be VBP cord-022678-86s3u7dl 94 12 compatible compatible JJ cord-022678-86s3u7dl 94 13 with with IN cord-022678-86s3u7dl 94 14 increased increase VBN cord-022678-86s3u7dl 94 15 arterial arterial JJ cord-022678-86s3u7dl 94 16 stiffness stiffness NN cord-022678-86s3u7dl 94 17 and and CC cord-022678-86s3u7dl 94 18 seem seem VBP cord-022678-86s3u7dl 94 19 to to TO cord-022678-86s3u7dl 94 20 be be VB cord-022678-86s3u7dl 94 21 influenced influence VBN cord-022678-86s3u7dl 94 22 more more RBR cord-022678-86s3u7dl 94 23 by by IN cord-022678-86s3u7dl 94 24 SBP SBP NNP cord-022678-86s3u7dl 94 25 than than IN cord-022678-86s3u7dl 94 26 DBP DBP NNP cord-022678-86s3u7dl 94 27 . . . cord-022678-86s3u7dl 95 1 The the DT cord-022678-86s3u7dl 95 2 implications implication NNS cord-022678-86s3u7dl 95 3 of of IN cord-022678-86s3u7dl 95 4 these these DT cord-022678-86s3u7dl 95 5 findings finding NNS cord-022678-86s3u7dl 95 6 should should MD cord-022678-86s3u7dl 95 7 be be VB cord-022678-86s3u7dl 95 8 further further RB cord-022678-86s3u7dl 95 9 investigated investigate VBN cord-022678-86s3u7dl 95 10 . . . cord-022678-86s3u7dl 96 1 Objectives objective NNS cord-022678-86s3u7dl 96 2 : : : cord-022678-86s3u7dl 96 3 Both both DT cord-022678-86s3u7dl 96 4 elevated elevate VBN cord-022678-86s3u7dl 96 5 mid mid JJ cord-022678-86s3u7dl 96 6 - - JJ cord-022678-86s3u7dl 96 7 trimester trimester JJ cord-022678-86s3u7dl 96 8 maternal maternal JJ cord-022678-86s3u7dl 96 9 serum serum NN cord-022678-86s3u7dl 96 10 hCG hcg NN cord-022678-86s3u7dl 96 11 and and CC cord-022678-86s3u7dl 96 12 abnormal abnormal JJ cord-022678-86s3u7dl 96 13 uterine uterine JJ cord-022678-86s3u7dl 96 14 artery artery NN cord-022678-86s3u7dl 96 15 Doppler doppler NN cord-022678-86s3u7dl 96 16 flow flow NN cord-022678-86s3u7dl 96 17 velocimetry velocimetry NN cord-022678-86s3u7dl 96 18 waveforms waveform NNS cord-022678-86s3u7dl 96 19 have have VBP cord-022678-86s3u7dl 96 20 been be VBN cord-022678-86s3u7dl 96 21 associated associate VBN cord-022678-86s3u7dl 96 22 with with IN cord-022678-86s3u7dl 96 23 adverse adverse JJ cord-022678-86s3u7dl 96 24 pregnancy pregnancy NN cord-022678-86s3u7dl 96 25 outcomes outcome NNS cord-022678-86s3u7dl 96 26 but but CC cord-022678-86s3u7dl 96 27 neither neither DT cord-022678-86s3u7dl 96 28 test test NN cord-022678-86s3u7dl 96 29 has have VBZ cord-022678-86s3u7dl 96 30 been be VBN cord-022678-86s3u7dl 96 31 demonstrated demonstrate VBN cord-022678-86s3u7dl 96 32 to to TO cord-022678-86s3u7dl 96 33 have have VB cord-022678-86s3u7dl 96 34 adequate adequate JJ cord-022678-86s3u7dl 96 35 utility utility NN cord-022678-86s3u7dl 96 36 as as IN cord-022678-86s3u7dl 96 37 a a DT cord-022678-86s3u7dl 96 38 predictive predictive JJ cord-022678-86s3u7dl 96 39 marker marker NN cord-022678-86s3u7dl 96 40 . . . cord-022678-86s3u7dl 97 1 We -PRON- PRP cord-022678-86s3u7dl 97 2 set set VBD cord-022678-86s3u7dl 97 3 out out RP cord-022678-86s3u7dl 97 4 to to TO cord-022678-86s3u7dl 97 5 assess assess VB cord-022678-86s3u7dl 97 6 the the DT cord-022678-86s3u7dl 97 7 predictive predictive JJ cord-022678-86s3u7dl 97 8 capacity capacity NN cord-022678-86s3u7dl 97 9 of of IN cord-022678-86s3u7dl 97 10 a a DT cord-022678-86s3u7dl 97 11 two two CD cord-022678-86s3u7dl 97 12 step step NN cord-022678-86s3u7dl 97 13 screening screening NN cord-022678-86s3u7dl 97 14 process process NN cord-022678-86s3u7dl 97 15 . . . cord-022678-86s3u7dl 98 1 Methods method NNS cord-022678-86s3u7dl 98 2 : : : cord-022678-86s3u7dl 98 3 In in IN cord-022678-86s3u7dl 98 4 our -PRON- PRP$ cord-022678-86s3u7dl 98 5 institution institution NN cord-022678-86s3u7dl 98 6 women woman NNS cord-022678-86s3u7dl 98 7 with with IN cord-022678-86s3u7dl 98 8 an an DT cord-022678-86s3u7dl 98 9 unexplained unexplained JJ cord-022678-86s3u7dl 98 10 elevated elevate VBN cord-022678-86s3u7dl 98 11 mid mid JJ cord-022678-86s3u7dl 98 12 - - JJ cord-022678-86s3u7dl 98 13 trimester trimester JJ cord-022678-86s3u7dl 98 14 hCG hcg NN cord-022678-86s3u7dl 98 15 level level NN cord-022678-86s3u7dl 98 16 (= (= NNP cord-022678-86s3u7dl 98 17 4.0 4.0 CD cord-022678-86s3u7dl 98 18 MoM mom NN cord-022678-86s3u7dl 98 19 ) ) -RRB- cord-022678-86s3u7dl 98 20 are be VBP cord-022678-86s3u7dl 98 21 offered offer VBN cord-022678-86s3u7dl 98 22 uterine uterine JJ cord-022678-86s3u7dl 98 23 artery artery NN cord-022678-86s3u7dl 98 24 Doppler Doppler NNP cord-022678-86s3u7dl 98 25 assessment assessment NN cord-022678-86s3u7dl 98 26 at at IN cord-022678-86s3u7dl 98 27 22 22 CD cord-022678-86s3u7dl 98 28 - - SYM cord-022678-86s3u7dl 98 29 24 24 CD cord-022678-86s3u7dl 98 30 weeks week NNS cord-022678-86s3u7dl 98 31 ' ' POS cord-022678-86s3u7dl 98 32 gestation gestation NN cord-022678-86s3u7dl 98 33 . . . cord-022678-86s3u7dl 99 1 We -PRON- PRP cord-022678-86s3u7dl 99 2 have have VBP cord-022678-86s3u7dl 99 3 audited audit VBN cord-022678-86s3u7dl 99 4 the the DT cord-022678-86s3u7dl 99 5 utility utility NN cord-022678-86s3u7dl 99 6 of of IN cord-022678-86s3u7dl 99 7 this this DT cord-022678-86s3u7dl 99 8 practice practice NN cord-022678-86s3u7dl 99 9 by by IN cord-022678-86s3u7dl 99 10 reviewing review VBG cord-022678-86s3u7dl 99 11 the the DT cord-022678-86s3u7dl 99 12 prevalence prevalence NN cord-022678-86s3u7dl 99 13 of of IN cord-022678-86s3u7dl 99 14 the the DT cord-022678-86s3u7dl 99 15 adverse adverse JJ cord-022678-86s3u7dl 99 16 outcomes outcome NNS cord-022678-86s3u7dl 99 17 of of IN cord-022678-86s3u7dl 99 18 gestational gestational JJ cord-022678-86s3u7dl 99 19 hyertension hyertension NN cord-022678-86s3u7dl 99 20 , , , cord-022678-86s3u7dl 99 21 intrauterine intrauterine JJ cord-022678-86s3u7dl 99 22 growth growth NN cord-022678-86s3u7dl 99 23 restriction restriction NN cord-022678-86s3u7dl 99 24 ( ( -LRB- cord-022678-86s3u7dl 99 25 IUGR IUGR NNP cord-022678-86s3u7dl 99 26 ) ) -RRB- cord-022678-86s3u7dl 99 27 and and CC cord-022678-86s3u7dl 99 28 preterm preterm JJ cord-022678-86s3u7dl 99 29 birth birth NN cord-022678-86s3u7dl 99 30 . . . cord-022678-86s3u7dl 100 1 Results result NNS cord-022678-86s3u7dl 100 2 : : : cord-022678-86s3u7dl 101 1 Sixty sixty CD cord-022678-86s3u7dl 101 2 - - HYPH cord-022678-86s3u7dl 101 3 two two CD cord-022678-86s3u7dl 101 4 women woman NNS cord-022678-86s3u7dl 101 5 had have VBD cord-022678-86s3u7dl 101 6 a a DT cord-022678-86s3u7dl 101 7 serum serum NN cord-022678-86s3u7dl 101 8 hCG hcg NN cord-022678-86s3u7dl 101 9 = = SYM cord-022678-86s3u7dl 101 10 4.0 4.0 CD cord-022678-86s3u7dl 101 11 M0 M0 NNP cord-022678-86s3u7dl 101 12 M M NNP cord-022678-86s3u7dl 101 13 and and CC cord-022678-86s3u7dl 101 14 underwent undergo VBD cord-022678-86s3u7dl 101 15 Doppler Doppler NNP cord-022678-86s3u7dl 101 16 study study NN cord-022678-86s3u7dl 101 17 of of IN cord-022678-86s3u7dl 101 18 uterine uterine JJ cord-022678-86s3u7dl 101 19 artery artery NN cord-022678-86s3u7dl 101 20 flow flow NN cord-022678-86s3u7dl 101 21 velocity velocity NN cord-022678-86s3u7dl 101 22 waveform waveform NN cord-022678-86s3u7dl 101 23 ( ( -LRB- cord-022678-86s3u7dl 101 24 Ut Ut NNP cord-022678-86s3u7dl 101 25 AFVW AFVW NNP cord-022678-86s3u7dl 101 26 ) ) -RRB- cord-022678-86s3u7dl 101 27 . . . cord-022678-86s3u7dl 102 1 Notching notching NN cord-022678-86s3u7dl 102 2 of of IN cord-022678-86s3u7dl 102 3 the the DT cord-022678-86s3u7dl 102 4 Ut Ut NNP cord-022678-86s3u7dl 102 5 AFVW AFVW NNP cord-022678-86s3u7dl 102 6 afforded afford VBD cord-022678-86s3u7dl 102 7 better well RBR cord-022678-86s3u7dl 102 8 predictive predictive JJ cord-022678-86s3u7dl 102 9 utility utility NN cord-022678-86s3u7dl 102 10 for for IN cord-022678-86s3u7dl 102 11 any any DT cord-022678-86s3u7dl 102 12 outcome outcome NN cord-022678-86s3u7dl 102 13 than than IN cord-022678-86s3u7dl 102 14 the the DT cord-022678-86s3u7dl 102 15 resistance resistance NN cord-022678-86s3u7dl 102 16 index index NN cord-022678-86s3u7dl 102 17 ( ( -LRB- cord-022678-86s3u7dl 102 18 RI RI NNP cord-022678-86s3u7dl 102 19 ) ) -RRB- cord-022678-86s3u7dl 102 20 alone alone RB cord-022678-86s3u7dl 102 21 or or CC cord-022678-86s3u7dl 102 22 in in IN cord-022678-86s3u7dl 102 23 combination combination NN cord-022678-86s3u7dl 102 24 with with IN cord-022678-86s3u7dl 102 25 notching notching NN cord-022678-86s3u7dl 102 26 . . . cord-022678-86s3u7dl 103 1 For for IN cord-022678-86s3u7dl 103 2 a a DT cord-022678-86s3u7dl 103 3 composite composite JJ cord-022678-86s3u7dl 103 4 adverse adverse JJ cord-022678-86s3u7dl 103 5 outcome outcome NN cord-022678-86s3u7dl 103 6 of of IN cord-022678-86s3u7dl 103 7 gestational gestational JJ cord-022678-86s3u7dl 103 8 hypertension hypertension NN cord-022678-86s3u7dl 103 9 , , , cord-022678-86s3u7dl 103 10 birthweight birthweight JJ cord-022678-86s3u7dl 103 11 = = SYM cord-022678-86s3u7dl 103 12 10th 10th JJ cord-022678-86s3u7dl 103 13 centile centile NN cord-022678-86s3u7dl 103 14 and and CC cord-022678-86s3u7dl 103 15 preterm preterm JJ cord-022678-86s3u7dl 103 16 delivery delivery NN cord-022678-86s3u7dl 103 17 ( ( -LRB- cord-022678-86s3u7dl 103 18 < < NNP cord-022678-86s3u7dl 103 19 36 36 CD cord-022678-86s3u7dl 103 20 weeks week NNS cord-022678-86s3u7dl 103 21 ) ) -RRB- cord-022678-86s3u7dl 103 22 the the DT cord-022678-86s3u7dl 103 23 presence presence NN cord-022678-86s3u7dl 103 24 of of IN cord-022678-86s3u7dl 103 25 a a DT cord-022678-86s3u7dl 103 26 uterine uterine JJ cord-022678-86s3u7dl 103 27 notch notch NN cord-022678-86s3u7dl 103 28 alone alone RB cord-022678-86s3u7dl 103 29 had have VBD cord-022678-86s3u7dl 103 30 sensitivity sensitivity NN cord-022678-86s3u7dl 103 31 of of IN cord-022678-86s3u7dl 103 32 30.7 30.7 CD cord-022678-86s3u7dl 103 33 % % NN cord-022678-86s3u7dl 103 34 , , , cord-022678-86s3u7dl 103 35 specificity specificity NN cord-022678-86s3u7dl 103 36 of of IN cord-022678-86s3u7dl 103 37 93.8 93.8 CD cord-022678-86s3u7dl 103 38 % % NN cord-022678-86s3u7dl 103 39 , , , cord-022678-86s3u7dl 103 40 a a DT cord-022678-86s3u7dl 103 41 positive positive JJ cord-022678-86s3u7dl 103 42 likelihood likelihood NN cord-022678-86s3u7dl 103 43 ratio ratio NN cord-022678-86s3u7dl 103 44 of of IN cord-022678-86s3u7dl 103 45 4.95 4.95 CD cord-022678-86s3u7dl 103 46 and and CC cord-022678-86s3u7dl 103 47 a a DT cord-022678-86s3u7dl 103 48 negative negative JJ cord-022678-86s3u7dl 103 49 likelihood likelihood NN cord-022678-86s3u7dl 103 50 ratio ratio NN cord-022678-86s3u7dl 103 51 of of IN cord-022678-86s3u7dl 103 52 0.7 0.7 CD cord-022678-86s3u7dl 103 53 . . . cord-022678-86s3u7dl 104 1 For for IN cord-022678-86s3u7dl 104 2 the the DT cord-022678-86s3u7dl 104 3 identification identification NN cord-022678-86s3u7dl 104 4 of of IN cord-022678-86s3u7dl 104 5 severe severe JJ cord-022678-86s3u7dl 104 6 fetal fetal JJ cord-022678-86s3u7dl 104 7 growth growth NN cord-022678-86s3u7dl 104 8 restriction restriction NN cord-022678-86s3u7dl 104 9 , , , cord-022678-86s3u7dl 104 10 < < XX cord-022678-86s3u7dl 104 11 5th 5th JJ cord-022678-86s3u7dl 104 12 centile centile NN cord-022678-86s3u7dl 104 13 , , , cord-022678-86s3u7dl 104 14 and and CC cord-022678-86s3u7dl 104 15 pre pre JJ cord-022678-86s3u7dl 104 16 - - JJ cord-022678-86s3u7dl 104 17 eclampsia eclampsia JJ cord-022678-86s3u7dl 104 18 , , , cord-022678-86s3u7dl 104 19 the the DT cord-022678-86s3u7dl 104 20 presence presence NN cord-022678-86s3u7dl 104 21 of of IN cord-022678-86s3u7dl 104 22 a a DT cord-022678-86s3u7dl 104 23 notch notch NN cord-022678-86s3u7dl 104 24 offered offer VBD cord-022678-86s3u7dl 104 25 a a DT cord-022678-86s3u7dl 104 26 sensitivity sensitivity NN cord-022678-86s3u7dl 104 27 of of IN cord-022678-86s3u7dl 104 28 50 50 CD cord-022678-86s3u7dl 104 29 % % NN cord-022678-86s3u7dl 104 30 , , , cord-022678-86s3u7dl 104 31 specificity specificity NN cord-022678-86s3u7dl 104 32 of of IN cord-022678-86s3u7dl 104 33 96.3 96.3 CD cord-022678-86s3u7dl 104 34 % % NN cord-022678-86s3u7dl 104 35 , , , cord-022678-86s3u7dl 104 36 a a DT cord-022678-86s3u7dl 104 37 positive positive JJ cord-022678-86s3u7dl 104 38 likelihood likelihood NN cord-022678-86s3u7dl 104 39 ratio ratio NN cord-022678-86s3u7dl 104 40 of of IN cord-022678-86s3u7dl 104 41 13.5 13.5 CD cord-022678-86s3u7dl 104 42 and and CC cord-022678-86s3u7dl 104 43 a a DT cord-022678-86s3u7dl 104 44 negative negative JJ cord-022678-86s3u7dl 104 45 likelihood likelihood NN cord-022678-86s3u7dl 104 46 ratio ratio NN cord-022678-86s3u7dl 104 47 of of IN cord-022678-86s3u7dl 104 48 0.5 0.5 CD cord-022678-86s3u7dl 104 49 . . . cord-022678-86s3u7dl 105 1 Conclusions conclusion NNS cord-022678-86s3u7dl 105 2 : : : cord-022678-86s3u7dl 106 1 The the DT cord-022678-86s3u7dl 106 2 identification identification NN cord-022678-86s3u7dl 106 3 of of IN cord-022678-86s3u7dl 106 4 uterine uterine JJ cord-022678-86s3u7dl 106 5 artery artery NN cord-022678-86s3u7dl 106 6 notching notching NN cord-022678-86s3u7dl 106 7 by by IN cord-022678-86s3u7dl 106 8 Doppler Doppler NNP cord-022678-86s3u7dl 106 9 ultrasound ultrasound NN cord-022678-86s3u7dl 106 10 as as IN cord-022678-86s3u7dl 106 11 a a DT cord-022678-86s3u7dl 106 12 component component NN cord-022678-86s3u7dl 106 13 of of IN cord-022678-86s3u7dl 106 14 the the DT cord-022678-86s3u7dl 106 15 surveillance surveillance NN cord-022678-86s3u7dl 106 16 of of IN cord-022678-86s3u7dl 106 17 women woman NNS cord-022678-86s3u7dl 106 18 with with IN cord-022678-86s3u7dl 106 19 unexplained unexplained JJ cord-022678-86s3u7dl 106 20 elevated elevated JJ cord-022678-86s3u7dl 106 21 hCG hcg NN cord-022678-86s3u7dl 106 22 levels level NNS cord-022678-86s3u7dl 106 23 significantly significantly RB cord-022678-86s3u7dl 106 24 improves improve VBZ cord-022678-86s3u7dl 106 25 the the DT cord-022678-86s3u7dl 106 26 prediction prediction NN cord-022678-86s3u7dl 106 27 of of IN cord-022678-86s3u7dl 106 28 pre pre JJ cord-022678-86s3u7dl 106 29 - - JJ cord-022678-86s3u7dl 106 30 eclampsia eclampsia JJ cord-022678-86s3u7dl 106 31 and and CC cord-022678-86s3u7dl 106 32 severe severe JJ cord-022678-86s3u7dl 106 33 IUGR IUGR NNP cord-022678-86s3u7dl 106 34 . . . cord-022678-86s3u7dl 107 1 Low low JJ cord-022678-86s3u7dl 107 2 - - HYPH cord-022678-86s3u7dl 107 3 molecular molecular JJ cord-022678-86s3u7dl 107 4 - - HYPH cord-022678-86s3u7dl 107 5 weight weight NN cord-022678-86s3u7dl 107 6 ( ( -LRB- cord-022678-86s3u7dl 107 7 LMW LMW NNP cord-022678-86s3u7dl 107 8 ) ) -RRB- cord-022678-86s3u7dl 107 9 heparins heparin NNS cord-022678-86s3u7dl 107 10 have have VBP cord-022678-86s3u7dl 107 11 been be VBN cord-022678-86s3u7dl 107 12 shown show VBN cord-022678-86s3u7dl 107 13 to to TO cord-022678-86s3u7dl 107 14 be be VB cord-022678-86s3u7dl 107 15 at at IN cord-022678-86s3u7dl 107 16 least least JJS cord-022678-86s3u7dl 107 17 as as RB cord-022678-86s3u7dl 107 18 effective effective JJ cord-022678-86s3u7dl 107 19 as as IN cord-022678-86s3u7dl 107 20 unfractionated unfractionated JJ cord-022678-86s3u7dl 107 21 ( ( -LRB- cord-022678-86s3u7dl 107 22 UF UF NNP cord-022678-86s3u7dl 107 23 ) ) -RRB- cord-022678-86s3u7dl 107 24 heparin heparin NN cord-022678-86s3u7dl 107 25 in in IN cord-022678-86s3u7dl 107 26 the the DT cord-022678-86s3u7dl 107 27 treatment treatment NN cord-022678-86s3u7dl 107 28 of of IN cord-022678-86s3u7dl 107 29 deep deep JJ cord-022678-86s3u7dl 107 30 venous venous JJ cord-022678-86s3u7dl 107 31 thrombosis thrombosis NN cord-022678-86s3u7dl 107 32 ( ( -LRB- cord-022678-86s3u7dl 107 33 DVT DVT NNP cord-022678-86s3u7dl 107 34 ) ) -RRB- cord-022678-86s3u7dl 107 35 in in IN cord-022678-86s3u7dl 107 36 non non JJ cord-022678-86s3u7dl 107 37 - - JJ cord-022678-86s3u7dl 107 38 pregnant pregnant JJ cord-022678-86s3u7dl 107 39 subjects subject NNS cord-022678-86s3u7dl 107 40 . . . cord-022678-86s3u7dl 108 1 LMW LMW NNP cord-022678-86s3u7dl 108 2 heparins heparin NNS cord-022678-86s3u7dl 108 3 have have VBP cord-022678-86s3u7dl 108 4 been be VBN cord-022678-86s3u7dl 108 5 shown show VBN cord-022678-86s3u7dl 108 6 to to TO cord-022678-86s3u7dl 108 7 be be VB cord-022678-86s3u7dl 108 8 safe safe JJ cord-022678-86s3u7dl 108 9 when when WRB cord-022678-86s3u7dl 108 10 used use VBN cord-022678-86s3u7dl 108 11 during during IN cord-022678-86s3u7dl 108 12 pregnancy pregnancy NN cord-022678-86s3u7dl 108 13 as as IN cord-022678-86s3u7dl 108 14 they -PRON- PRP cord-022678-86s3u7dl 108 15 do do VBP cord-022678-86s3u7dl 108 16 not not RB cord-022678-86s3u7dl 108 17 cross cross VB cord-022678-86s3u7dl 108 18 the the DT cord-022678-86s3u7dl 108 19 placenta placenta NN cord-022678-86s3u7dl 108 20 . . . cord-022678-86s3u7dl 109 1 Up up IN cord-022678-86s3u7dl 109 2 to to IN cord-022678-86s3u7dl 109 3 now now RB cord-022678-86s3u7dl 109 4 they -PRON- PRP cord-022678-86s3u7dl 109 5 have have VBP cord-022678-86s3u7dl 109 6 been be VBN cord-022678-86s3u7dl 109 7 used use VBN cord-022678-86s3u7dl 109 8 mainly mainly RB cord-022678-86s3u7dl 109 9 in in IN cord-022678-86s3u7dl 109 10 thromboprophylaxis thromboprophylaxis NN cord-022678-86s3u7dl 109 11 during during IN cord-022678-86s3u7dl 109 12 pregnancy pregnancy NN cord-022678-86s3u7dl 109 13 and and CC cord-022678-86s3u7dl 109 14 rarely rarely RB cord-022678-86s3u7dl 109 15 in in IN cord-022678-86s3u7dl 109 16 the the DT cord-022678-86s3u7dl 109 17 treatment treatment NN cord-022678-86s3u7dl 109 18 of of IN cord-022678-86s3u7dl 109 19 acute acute JJ cord-022678-86s3u7dl 109 20 DVT DVT NNP cord-022678-86s3u7dl 109 21 in in IN cord-022678-86s3u7dl 109 22 pregnant pregnant JJ cord-022678-86s3u7dl 109 23 women woman NNS cord-022678-86s3u7dl 109 24 . . . cord-022678-86s3u7dl 110 1 In in IN cord-022678-86s3u7dl 110 2 a a DT cord-022678-86s3u7dl 110 3 prospective prospective JJ cord-022678-86s3u7dl 110 4 observational observational JJ cord-022678-86s3u7dl 110 5 study study NN cord-022678-86s3u7dl 110 6 we -PRON- PRP cord-022678-86s3u7dl 110 7 compared compare VBD cord-022678-86s3u7dl 110 8 the the DT cord-022678-86s3u7dl 110 9 effectiveness effectiveness NN cord-022678-86s3u7dl 110 10 and and CC cord-022678-86s3u7dl 110 11 safety safety NN cord-022678-86s3u7dl 110 12 of of IN cord-022678-86s3u7dl 110 13 the the DT cord-022678-86s3u7dl 110 14 LMW LMW NNP cord-022678-86s3u7dl 110 15 heparin heparin NN cord-022678-86s3u7dl 110 16 dalteparin dalteparin NN cord-022678-86s3u7dl 110 17 versus versus IN cord-022678-86s3u7dl 110 18 UF UF NNP cord-022678-86s3u7dl 110 19 heparin heparin JJ cord-022678-86s3u7dl 110 20 as as IN cord-022678-86s3u7dl 110 21 initial initial JJ cord-022678-86s3u7dl 110 22 treatment treatment NN cord-022678-86s3u7dl 110 23 ( ( -LRB- cord-022678-86s3u7dl 110 24 first first JJ cord-022678-86s3u7dl 110 25 week week NN cord-022678-86s3u7dl 110 26 ) ) -RRB- cord-022678-86s3u7dl 110 27 of of IN cord-022678-86s3u7dl 110 28 DVT DVT NNP cord-022678-86s3u7dl 110 29 during during IN cord-022678-86s3u7dl 110 30 pregnancy pregnancy NN cord-022678-86s3u7dl 110 31 . . . cord-022678-86s3u7dl 111 1 After after IN cord-022678-86s3u7dl 111 2 confirmation confirmation NN cord-022678-86s3u7dl 111 3 of of IN cord-022678-86s3u7dl 111 4 DVT DVT NNP cord-022678-86s3u7dl 111 5 by by IN cord-022678-86s3u7dl 111 6 ultrasonography ultrasonography NN cord-022678-86s3u7dl 111 7 , , , cord-022678-86s3u7dl 111 8 10 10 CD cord-022678-86s3u7dl 111 9 women woman NNS cord-022678-86s3u7dl 111 10 were be VBD cord-022678-86s3u7dl 111 11 treated treat VBN cord-022678-86s3u7dl 111 12 with with IN cord-022678-86s3u7dl 111 13 UF UF NNP cord-022678-86s3u7dl 111 14 heparin heparin NNP cord-022678-86s3u7dl 112 1 ( ( -LRB- cord-022678-86s3u7dl 112 2 25430 25430 CD cord-022678-86s3u7dl 112 3 IU IU NNP cord-022678-86s3u7dl 112 4 / / SYM cord-022678-86s3u7dl 112 5 day day NN cord-022678-86s3u7dl 112 6 , , , cord-022678-86s3u7dl 112 7 mean mean JJ cord-022678-86s3u7dl 112 8 ) ) -RRB- cord-022678-86s3u7dl 112 9 and and CC cord-022678-86s3u7dl 112 10 21 21 CD cord-022678-86s3u7dl 112 11 women woman NNS cord-022678-86s3u7dl 112 12 with with IN cord-022678-86s3u7dl 112 13 dalteparin dalteparin NNP cord-022678-86s3u7dl 112 14 ( ( -LRB- cord-022678-86s3u7dl 112 15 16000 16000 CD cord-022678-86s3u7dl 112 16 IU IU NNP cord-022678-86s3u7dl 112 17 / / SYM cord-022678-86s3u7dl 112 18 day day NN cord-022678-86s3u7dl 112 19 , , , cord-022678-86s3u7dl 112 20 mean mean JJ cord-022678-86s3u7dl 112 21 ) ) -RRB- cord-022678-86s3u7dl 112 22 for for IN cord-022678-86s3u7dl 112 23 7 7 CD cord-022678-86s3u7dl 112 24 days day NNS cord-022678-86s3u7dl 112 25 and and CC cord-022678-86s3u7dl 112 26 thereafter thereafter RB cord-022678-86s3u7dl 112 27 all all DT cord-022678-86s3u7dl 112 28 women woman NNS cord-022678-86s3u7dl 112 29 were be VBD cord-022678-86s3u7dl 112 30 given give VBN cord-022678-86s3u7dl 112 31 treatment treatment NN cord-022678-86s3u7dl 112 32 doses dose NNS cord-022678-86s3u7dl 112 33 of of IN cord-022678-86s3u7dl 112 34 LMWheparin LMWheparin NNP cord-022678-86s3u7dl 112 35 for for IN cord-022678-86s3u7dl 112 36 another another DT cord-022678-86s3u7dl 112 37 2 2 CD cord-022678-86s3u7dl 112 38 weeks week NNS cord-022678-86s3u7dl 112 39 . . . cord-022678-86s3u7dl 113 1 The the DT cord-022678-86s3u7dl 113 2 dose dose NN cord-022678-86s3u7dl 113 3 was be VBD cord-022678-86s3u7dl 113 4 then then RB cord-022678-86s3u7dl 113 5 gradually gradually RB cord-022678-86s3u7dl 113 6 decreased decrease VBD cord-022678-86s3u7dl 113 7 and and CC cord-022678-86s3u7dl 113 8 kept keep VBD cord-022678-86s3u7dl 113 9 at at IN cord-022678-86s3u7dl 113 10 high high JJ cord-022678-86s3u7dl 113 11 prophylactic prophylactic JJ cord-022678-86s3u7dl 113 12 dose dose NN cord-022678-86s3u7dl 113 13 until until IN cord-022678-86s3u7dl 113 14 delivery delivery NN cord-022678-86s3u7dl 113 15 . . . cord-022678-86s3u7dl 114 1 One one CD cord-022678-86s3u7dl 114 2 patient patient NN cord-022678-86s3u7dl 114 3 in in IN cord-022678-86s3u7dl 114 4 the the DT cord-022678-86s3u7dl 114 5 dalteparin dalteparin NNP cord-022678-86s3u7dl 114 6 group group NN cord-022678-86s3u7dl 114 7 had have VBD cord-022678-86s3u7dl 114 8 recurrence recurrence NN cord-022678-86s3u7dl 114 9 of of IN cord-022678-86s3u7dl 114 10 DVT DVT NNP cord-022678-86s3u7dl 114 11 2 2 CD cord-022678-86s3u7dl 114 12 weeks week NNS cord-022678-86s3u7dl 114 13 after after IN cord-022678-86s3u7dl 114 14 starting start VBG cord-022678-86s3u7dl 114 15 the the DT cord-022678-86s3u7dl 114 16 treatment treatment NN cord-022678-86s3u7dl 114 17 . . . cord-022678-86s3u7dl 115 1 No no DT cord-022678-86s3u7dl 115 2 differences difference NNS cord-022678-86s3u7dl 115 3 were be VBD cord-022678-86s3u7dl 115 4 observed observe VBN cord-022678-86s3u7dl 115 5 between between IN cord-022678-86s3u7dl 115 6 the the DT cord-022678-86s3u7dl 115 7 groups group NNS cord-022678-86s3u7dl 115 8 in in IN cord-022678-86s3u7dl 115 9 symptoms symptom NNS cord-022678-86s3u7dl 115 10 or or CC cord-022678-86s3u7dl 115 11 bleeding bleed VBG cord-022678-86s3u7dl 115 12 complications complication NNS cord-022678-86s3u7dl 115 13 during during IN cord-022678-86s3u7dl 115 14 pregnancy pregnancy NN cord-022678-86s3u7dl 115 15 and and CC cord-022678-86s3u7dl 115 16 delivery delivery NN cord-022678-86s3u7dl 115 17 . . . cord-022678-86s3u7dl 116 1 Our -PRON- PRP$ cord-022678-86s3u7dl 116 2 results result NNS cord-022678-86s3u7dl 116 3 indicate indicate VBP cord-022678-86s3u7dl 116 4 that that IN cord-022678-86s3u7dl 116 5 LMW lmw NN cord-022678-86s3u7dl 116 6 heparin heparin NN cord-022678-86s3u7dl 116 7 is be VBZ cord-022678-86s3u7dl 116 8 as as RB cord-022678-86s3u7dl 116 9 effective effective JJ cord-022678-86s3u7dl 116 10 and and CC cord-022678-86s3u7dl 116 11 safe safe JJ cord-022678-86s3u7dl 116 12 as as IN cord-022678-86s3u7dl 116 13 UF UF NNP cord-022678-86s3u7dl 116 14 heparin heparin JJ cord-022678-86s3u7dl 116 15 for for IN cord-022678-86s3u7dl 116 16 the the DT cord-022678-86s3u7dl 116 17 first first JJ cord-022678-86s3u7dl 116 18 week week NN cord-022678-86s3u7dl 116 19 of of IN cord-022678-86s3u7dl 116 20 treatment treatment NN cord-022678-86s3u7dl 116 21 , , , cord-022678-86s3u7dl 116 22 but but CC cord-022678-86s3u7dl 116 23 LMW lmw NN cord-022678-86s3u7dl 116 24 heparin heparin NN cord-022678-86s3u7dl 116 25 has have VBZ cord-022678-86s3u7dl 116 26 the the DT cord-022678-86s3u7dl 116 27 advantage advantage NN cord-022678-86s3u7dl 116 28 that that IN cord-022678-86s3u7dl 116 29 it -PRON- PRP cord-022678-86s3u7dl 116 30 is be VBZ cord-022678-86s3u7dl 116 31 easily easily RB cord-022678-86s3u7dl 116 32 administered administer VBN cord-022678-86s3u7dl 116 33 and and CC cord-022678-86s3u7dl 116 34 few few JJ cord-022678-86s3u7dl 116 35 laboratory laboratory NN cord-022678-86s3u7dl 116 36 controls control NNS cord-022678-86s3u7dl 116 37 are be VBP cord-022678-86s3u7dl 116 38 required require VBN cord-022678-86s3u7dl 116 39 . . . cord-022678-86s3u7dl 117 1 Metastatic metastatic JJ cord-022678-86s3u7dl 117 2 paraganglioma paraganglioma NNS cord-022678-86s3u7dl 117 3 and and CC cord-022678-86s3u7dl 117 4 pregnancy pregnancy NN cord-022678-86s3u7dl 117 5 : : : cord-022678-86s3u7dl 117 6 a a DT cord-022678-86s3u7dl 117 7 case case NN cord-022678-86s3u7dl 117 8 report report NN cord-022678-86s3u7dl 117 9 of of IN cord-022678-86s3u7dl 117 10 a a DT cord-022678-86s3u7dl 117 11 successful successful JJ cord-022678-86s3u7dl 117 12 pregnancy pregnancy NN cord-022678-86s3u7dl 117 13 outcome outcome NN cord-022678-86s3u7dl 117 14 ADAIR ADAIR NNP cord-022678-86s3u7dl 117 15 S S NNP cord-022678-86s3u7dl 117 16 , , , cord-022678-86s3u7dl 117 17 ELLWOOD ELLWOOD NNP cord-022678-86s3u7dl 117 18 D D NNP cord-022678-86s3u7dl 117 19 , , , cord-022678-86s3u7dl 117 20 YIP YIP NNP cord-022678-86s3u7dl 117 21 D D NNP cord-022678-86s3u7dl 117 22 , , , cord-022678-86s3u7dl 117 23 CARNEY CARNEY NNP cord-022678-86s3u7dl 117 24 G G NNP cord-022678-86s3u7dl 117 25 , , , cord-022678-86s3u7dl 117 26 KECSKES KECSKES NNP cord-022678-86s3u7dl 117 27 Z Z NNP cord-022678-86s3u7dl 117 28 and and CC cord-022678-86s3u7dl 117 29 TUCKER TUCKER NNP cord-022678-86s3u7dl 117 30 K K NNP cord-022678-86s3u7dl 117 31 Metastatic Metastatic NNP cord-022678-86s3u7dl 117 32 para para NNP cord-022678-86s3u7dl 117 33 - - HYPH cord-022678-86s3u7dl 117 34 ganglioma ganglioma NNP cord-022678-86s3u7dl 117 35 is be VBZ cord-022678-86s3u7dl 117 36 a a DT cord-022678-86s3u7dl 117 37 very very RB cord-022678-86s3u7dl 117 38 rare rare JJ cord-022678-86s3u7dl 117 39 condition condition NN cord-022678-86s3u7dl 117 40 , , , cord-022678-86s3u7dl 117 41 recently recently RB cord-022678-86s3u7dl 117 42 shown show VBN cord-022678-86s3u7dl 117 43 to to TO cord-022678-86s3u7dl 117 44 be be VB cord-022678-86s3u7dl 117 45 sometimes sometimes RB cord-022678-86s3u7dl 117 46 due due JJ cord-022678-86s3u7dl 117 47 to to IN cord-022678-86s3u7dl 117 48 autosomal autosomal JJ cord-022678-86s3u7dl 117 49 , , , cord-022678-86s3u7dl 117 50 dominantly dominantly RB cord-022678-86s3u7dl 117 51 transmitted transmit VBN cord-022678-86s3u7dl 117 52 mutations mutation NNS cord-022678-86s3u7dl 117 53 in in IN cord-022678-86s3u7dl 117 54 SDHB SDHB NNP cord-022678-86s3u7dl 117 55 , , , cord-022678-86s3u7dl 117 56 D D NNP cord-022678-86s3u7dl 117 57 and and CC cord-022678-86s3u7dl 117 58 C C NNP cord-022678-86s3u7dl 117 59 genes gene NNS cord-022678-86s3u7dl 117 60 . . . cord-022678-86s3u7dl 118 1 The the DT cord-022678-86s3u7dl 118 2 patient patient NN cord-022678-86s3u7dl 118 3 ( ( -LRB- cord-022678-86s3u7dl 118 4 28 28 CD cord-022678-86s3u7dl 118 5 years year NNS cord-022678-86s3u7dl 118 6 old old JJ cord-022678-86s3u7dl 118 7 ) ) -RRB- cord-022678-86s3u7dl 118 8 presented present VBN cord-022678-86s3u7dl 118 9 with with IN cord-022678-86s3u7dl 118 10 recurrent recurrent JJ cord-022678-86s3u7dl 118 11 abdominal abdominal JJ cord-022678-86s3u7dl 118 12 pain pain NN cord-022678-86s3u7dl 118 13 and and CC cord-022678-86s3u7dl 118 14 a a DT cord-022678-86s3u7dl 118 15 3 3 CD cord-022678-86s3u7dl 118 16 year year NN cord-022678-86s3u7dl 118 17 history history NN cord-022678-86s3u7dl 118 18 of of IN cord-022678-86s3u7dl 118 19 hypertension hypertension NN cord-022678-86s3u7dl 118 20 . . . cord-022678-86s3u7dl 119 1 CT CT NNP cord-022678-86s3u7dl 119 2 scan scan NNP cord-022678-86s3u7dl 119 3 demonstrated demonstrate VBD cord-022678-86s3u7dl 119 4 a a DT cord-022678-86s3u7dl 119 5 para para JJ cord-022678-86s3u7dl 119 6 - - HYPH cord-022678-86s3u7dl 119 7 aortic aortic JJ cord-022678-86s3u7dl 119 8 mass mass NN cord-022678-86s3u7dl 119 9 , , , cord-022678-86s3u7dl 119 10 and and CC cord-022678-86s3u7dl 119 11 MIBG MIBG NNP cord-022678-86s3u7dl 119 12 scan scan NNP cord-022678-86s3u7dl 119 13 revealed reveal VBD cord-022678-86s3u7dl 119 14 three three CD cord-022678-86s3u7dl 119 15 intra intra JJ cord-022678-86s3u7dl 119 16 - - JJ cord-022678-86s3u7dl 119 17 abdominal abdominal JJ cord-022678-86s3u7dl 119 18 foci foci NN cord-022678-86s3u7dl 119 19 . . . cord-022678-86s3u7dl 120 1 Surgical surgical JJ cord-022678-86s3u7dl 120 2 resection resection NN cord-022678-86s3u7dl 120 3 of of IN cord-022678-86s3u7dl 120 4 the the DT cord-022678-86s3u7dl 120 5 tumours tumour NNS cord-022678-86s3u7dl 120 6 followed follow VBN cord-022678-86s3u7dl 120 7 and and CC cord-022678-86s3u7dl 120 8 histology histology NN cord-022678-86s3u7dl 120 9 confirmed confirm VBD cord-022678-86s3u7dl 120 10 metastatic metastatic JJ cord-022678-86s3u7dl 120 11 parganglioma parganglioma NNP cord-022678-86s3u7dl 120 12 . . . cord-022678-86s3u7dl 121 1 She -PRON- PRP cord-022678-86s3u7dl 121 2 subsequently subsequently RB cord-022678-86s3u7dl 121 3 developed develop VBD cord-022678-86s3u7dl 121 4 additional additional JJ cord-022678-86s3u7dl 121 5 lesions lesion NNS cord-022678-86s3u7dl 121 6 in in IN cord-022678-86s3u7dl 121 7 her -PRON- PRP$ cord-022678-86s3u7dl 121 8 thorax thorax NN cord-022678-86s3u7dl 121 9 and and CC cord-022678-86s3u7dl 121 10 left left JJ cord-022678-86s3u7dl 121 11 hip hip NN cord-022678-86s3u7dl 121 12 , , , cord-022678-86s3u7dl 121 13 and and CC cord-022678-86s3u7dl 121 14 was be VBD cord-022678-86s3u7dl 121 15 treated treat VBN cord-022678-86s3u7dl 121 16 with with IN cord-022678-86s3u7dl 121 17 ablative ablative JJ cord-022678-86s3u7dl 121 18 MIBG MIBG NNP cord-022678-86s3u7dl 121 19 therapy therapy NN cord-022678-86s3u7dl 121 20 . . . cord-022678-86s3u7dl 122 1 She -PRON- PRP cord-022678-86s3u7dl 122 2 became become VBD cord-022678-86s3u7dl 122 3 inadvertently inadvertently RB cord-022678-86s3u7dl 122 4 pregnant pregnant JJ cord-022678-86s3u7dl 122 5 in in IN cord-022678-86s3u7dl 122 6 early early JJ cord-022678-86s3u7dl 122 7 2003 2003 CD cord-022678-86s3u7dl 122 8 , , , cord-022678-86s3u7dl 122 9 and and CC cord-022678-86s3u7dl 122 10 underwent undergo VBD cord-022678-86s3u7dl 122 11 further further JJ cord-022678-86s3u7dl 122 12 MIBG MIBG NNP cord-022678-86s3u7dl 122 13 and and CC cord-022678-86s3u7dl 122 14 CT CT NNP cord-022678-86s3u7dl 122 15 scans scan NNS cord-022678-86s3u7dl 122 16 in in IN cord-022678-86s3u7dl 122 17 early early JJ cord-022678-86s3u7dl 122 18 pregnancy pregnancy NN cord-022678-86s3u7dl 122 19 prior prior RB cord-022678-86s3u7dl 122 20 to to IN cord-022678-86s3u7dl 122 21 the the DT cord-022678-86s3u7dl 122 22 diagnosis diagnosis NN cord-022678-86s3u7dl 122 23 . . . cord-022678-86s3u7dl 123 1 She -PRON- PRP cord-022678-86s3u7dl 123 2 was be VBD cord-022678-86s3u7dl 123 3 seen see VBN cord-022678-86s3u7dl 123 4 for for IN cord-022678-86s3u7dl 123 5 antenatal antenatal JJ cord-022678-86s3u7dl 123 6 care care NN cord-022678-86s3u7dl 123 7 at at IN cord-022678-86s3u7dl 123 8 12 12 CD cord-022678-86s3u7dl 123 9 weeks week NNS cord-022678-86s3u7dl 123 10 and and CC cord-022678-86s3u7dl 123 11 counselled counsel VBD cord-022678-86s3u7dl 123 12 about about IN cord-022678-86s3u7dl 123 13 the the DT cord-022678-86s3u7dl 123 14 risks risk NNS cord-022678-86s3u7dl 123 15 of of IN cord-022678-86s3u7dl 123 16 continuing continue VBG cord-022678-86s3u7dl 123 17 the the DT cord-022678-86s3u7dl 123 18 pregnancy pregnancy NN cord-022678-86s3u7dl 123 19 , , , cord-022678-86s3u7dl 123 20 as as RB cord-022678-86s3u7dl 123 21 well well RB cord-022678-86s3u7dl 123 22 as as IN cord-022678-86s3u7dl 123 23 the the DT cord-022678-86s3u7dl 123 24 risks risk NNS cord-022678-86s3u7dl 123 25 to to IN cord-022678-86s3u7dl 123 26 the the DT cord-022678-86s3u7dl 123 27 fetus fetus NN cord-022678-86s3u7dl 123 28 . . . cord-022678-86s3u7dl 124 1 Blood blood NN cord-022678-86s3u7dl 124 2 pressure pressure NN cord-022678-86s3u7dl 124 3 medication medication NN cord-022678-86s3u7dl 124 4 initially initially RB cord-022678-86s3u7dl 124 5 was be VBD cord-022678-86s3u7dl 124 6 with with IN cord-022678-86s3u7dl 124 7 Phenoxybenzamine Phenoxybenzamine NNP cord-022678-86s3u7dl 124 8 , , , cord-022678-86s3u7dl 124 9 but but CC cord-022678-86s3u7dl 124 10 this this DT cord-022678-86s3u7dl 124 11 was be VBD cord-022678-86s3u7dl 124 12 changed change VBN cord-022678-86s3u7dl 124 13 to to IN cord-022678-86s3u7dl 124 14 Labetalol Labetalol NNP cord-022678-86s3u7dl 124 15 100 100 CD cord-022678-86s3u7dl 124 16 mg mg NN cord-022678-86s3u7dl 125 1 b.d b.d NNP cord-022678-86s3u7dl 125 2 . . . cord-022678-86s3u7dl 126 1 at at IN cord-022678-86s3u7dl 126 2 18 18 CD cord-022678-86s3u7dl 126 3 weeks week NNS cord-022678-86s3u7dl 126 4 with with IN cord-022678-86s3u7dl 126 5 good good JJ cord-022678-86s3u7dl 126 6 control control NN cord-022678-86s3u7dl 126 7 . . . cord-022678-86s3u7dl 127 1 Ultrasound ultrasound NN cord-022678-86s3u7dl 127 2 scans scan NNS cord-022678-86s3u7dl 127 3 at at IN cord-022678-86s3u7dl 127 4 12 12 CD cord-022678-86s3u7dl 127 5 , , , cord-022678-86s3u7dl 127 6 18 18 CD cord-022678-86s3u7dl 127 7 , , , cord-022678-86s3u7dl 127 8 24 24 CD cord-022678-86s3u7dl 127 9 , , , cord-022678-86s3u7dl 127 10 28 28 CD cord-022678-86s3u7dl 127 11 and and CC cord-022678-86s3u7dl 127 12 31 31 CD cord-022678-86s3u7dl 127 13 weeks week NNS cord-022678-86s3u7dl 127 14 were be VBD cord-022678-86s3u7dl 127 15 normal normal JJ cord-022678-86s3u7dl 127 16 . . . cord-022678-86s3u7dl 128 1 After after IN cord-022678-86s3u7dl 128 2 corticosteroid corticosteroid NNP cord-022678-86s3u7dl 128 3 administration administration NNP cord-022678-86s3u7dl 128 4 , , , cord-022678-86s3u7dl 128 5 she -PRON- PRP cord-022678-86s3u7dl 128 6 underwent undergo VBD cord-022678-86s3u7dl 128 7 elective elective JJ cord-022678-86s3u7dl 128 8 Caesarean caesarean JJ cord-022678-86s3u7dl 128 9 section section NN cord-022678-86s3u7dl 128 10 at at IN cord-022678-86s3u7dl 128 11 32 32 CD cord-022678-86s3u7dl 128 12 weeks week NNS cord-022678-86s3u7dl 128 13 to to TO cord-022678-86s3u7dl 128 14 allow allow VB cord-022678-86s3u7dl 128 15 for for IN cord-022678-86s3u7dl 128 16 further further JJ cord-022678-86s3u7dl 128 17 MIBG MIBG NNP cord-022678-86s3u7dl 128 18 ablative ablative JJ cord-022678-86s3u7dl 128 19 therapy therapy NN cord-022678-86s3u7dl 128 20 to to TO cord-022678-86s3u7dl 128 21 take take VB cord-022678-86s3u7dl 128 22 place place NN cord-022678-86s3u7dl 128 23 . . . cord-022678-86s3u7dl 129 1 The the DT cord-022678-86s3u7dl 129 2 infant infant NN cord-022678-86s3u7dl 129 3 was be VBD cord-022678-86s3u7dl 129 4 female female JJ cord-022678-86s3u7dl 129 5 , , , cord-022678-86s3u7dl 129 6 weighed weigh VBD cord-022678-86s3u7dl 129 7 1820 1820 CD cord-022678-86s3u7dl 129 8 g g NN cord-022678-86s3u7dl 129 9 and and CC cord-022678-86s3u7dl 129 10 required require VBN cord-022678-86s3u7dl 129 11 only only JJ cord-022678-86s3u7dl 129 12 short short JJ cord-022678-86s3u7dl 129 13 - - HYPH cord-022678-86s3u7dl 129 14 term term NN cord-022678-86s3u7dl 129 15 ventilation ventilation NN cord-022678-86s3u7dl 129 16 for for IN cord-022678-86s3u7dl 129 17 hyaline hyaline JJ cord-022678-86s3u7dl 129 18 membrane membrane NN cord-022678-86s3u7dl 129 19 disease disease NN cord-022678-86s3u7dl 129 20 . . . cord-022678-86s3u7dl 130 1 This this DT cord-022678-86s3u7dl 130 2 case case NN cord-022678-86s3u7dl 130 3 illustrates illustrate VBZ cord-022678-86s3u7dl 130 4 a a DT cord-022678-86s3u7dl 130 5 successful successful JJ cord-022678-86s3u7dl 130 6 pregnancy pregnancy NN cord-022678-86s3u7dl 130 7 outcome outcome NN cord-022678-86s3u7dl 130 8 in in IN cord-022678-86s3u7dl 130 9 a a DT cord-022678-86s3u7dl 130 10 woman woman NN cord-022678-86s3u7dl 130 11 with with IN cord-022678-86s3u7dl 130 12 a a DT cord-022678-86s3u7dl 130 13 serious serious JJ cord-022678-86s3u7dl 130 14 , , , cord-022678-86s3u7dl 130 15 and and CC cord-022678-86s3u7dl 130 16 potentially potentially RB cord-022678-86s3u7dl 130 17 lethal lethal JJ cord-022678-86s3u7dl 130 18 condition condition NN cord-022678-86s3u7dl 130 19 . . . cord-022678-86s3u7dl 131 1 There there EX cord-022678-86s3u7dl 131 2 were be VBD cord-022678-86s3u7dl 131 3 particular particular JJ cord-022678-86s3u7dl 131 4 unknown unknown JJ cord-022678-86s3u7dl 131 5 fetal fetal JJ cord-022678-86s3u7dl 131 6 risks risk NNS cord-022678-86s3u7dl 131 7 , , , cord-022678-86s3u7dl 131 8 both both CC cord-022678-86s3u7dl 131 9 teratogenic teratogenic JJ cord-022678-86s3u7dl 131 10 and and CC cord-022678-86s3u7dl 131 11 genetic genetic JJ cord-022678-86s3u7dl 131 12 , , , cord-022678-86s3u7dl 131 13 as as RB cord-022678-86s3u7dl 131 14 well well RB cord-022678-86s3u7dl 131 15 as as IN cord-022678-86s3u7dl 131 16 potentially potentially RB cord-022678-86s3u7dl 131 17 serious serious JJ cord-022678-86s3u7dl 131 18 maternal maternal JJ cord-022678-86s3u7dl 131 19 risks risk NNS cord-022678-86s3u7dl 131 20 of of IN cord-022678-86s3u7dl 131 21 severe severe JJ cord-022678-86s3u7dl 131 22 hypertension hypertension NN cord-022678-86s3u7dl 131 23 and and CC cord-022678-86s3u7dl 131 24 disease disease NN cord-022678-86s3u7dl 131 25 progression progression NN cord-022678-86s3u7dl 131 26 . . . cord-022678-86s3u7dl 132 1 A a DT cord-022678-86s3u7dl 132 2 multidisciplinary multidisciplinary JJ cord-022678-86s3u7dl 132 3 approach approach NN cord-022678-86s3u7dl 132 4 to to IN cord-022678-86s3u7dl 132 5 management management NN cord-022678-86s3u7dl 132 6 was be VBD cord-022678-86s3u7dl 132 7 an an DT cord-022678-86s3u7dl 132 8 essential essential JJ cord-022678-86s3u7dl 132 9 ingredient ingredient NN cord-022678-86s3u7dl 132 10 in in IN cord-022678-86s3u7dl 132 11 this this DT cord-022678-86s3u7dl 132 12 case case NN cord-022678-86s3u7dl 132 13 . . . cord-022678-86s3u7dl 133 1 Case case NN cord-022678-86s3u7dl 133 2 reports report NNS cord-022678-86s3u7dl 133 3 have have VBP cord-022678-86s3u7dl 133 4 shown show VBN cord-022678-86s3u7dl 133 5 that that IN cord-022678-86s3u7dl 133 6 pre pre NNS cord-022678-86s3u7dl 133 7 - - NNS cord-022678-86s3u7dl 133 8 eclamptics eclamptic NNS cord-022678-86s3u7dl 133 9 with with IN cord-022678-86s3u7dl 133 10 visual visual JJ cord-022678-86s3u7dl 133 11 disturbances disturbance NNS cord-022678-86s3u7dl 133 12 can can MD cord-022678-86s3u7dl 133 13 have have VB cord-022678-86s3u7dl 133 14 retinal retinal JJ cord-022678-86s3u7dl 133 15 detachments detachment NNS cord-022678-86s3u7dl 133 16 . . . cord-022678-86s3u7dl 134 1 The the DT cord-022678-86s3u7dl 134 2 aim aim NN cord-022678-86s3u7dl 134 3 of of IN cord-022678-86s3u7dl 134 4 this this DT cord-022678-86s3u7dl 134 5 study study NN cord-022678-86s3u7dl 134 6 was be VBD cord-022678-86s3u7dl 134 7 to to TO cord-022678-86s3u7dl 134 8 identify identify VB cord-022678-86s3u7dl 134 9 the the DT cord-022678-86s3u7dl 134 10 nature nature NN cord-022678-86s3u7dl 134 11 of of IN cord-022678-86s3u7dl 134 12 ophthalmological ophthalmological JJ cord-022678-86s3u7dl 134 13 abnormalities abnormality NNS cord-022678-86s3u7dl 134 14 in in IN cord-022678-86s3u7dl 134 15 patients patient NNS cord-022678-86s3u7dl 134 16 with with IN cord-022678-86s3u7dl 134 17 pre pre JJ cord-022678-86s3u7dl 134 18 - - JJ cord-022678-86s3u7dl 134 19 eclampsia eclampsia JJ cord-022678-86s3u7dl 134 20 and and CC cord-022678-86s3u7dl 134 21 persistent persistent JJ cord-022678-86s3u7dl 134 22 visual visual JJ cord-022678-86s3u7dl 134 23 disturbance disturbance NN cord-022678-86s3u7dl 134 24 beyond beyond IN cord-022678-86s3u7dl 134 25 delivery delivery NN cord-022678-86s3u7dl 134 26 . . . cord-022678-86s3u7dl 135 1 All all DT cord-022678-86s3u7dl 135 2 women woman NNS cord-022678-86s3u7dl 135 3 with with IN cord-022678-86s3u7dl 135 4 pre pre JJ cord-022678-86s3u7dl 135 5 - - JJ cord-022678-86s3u7dl 135 6 eclampsia eclampsia JJ cord-022678-86s3u7dl 135 7 and and CC cord-022678-86s3u7dl 135 8 visual visual JJ cord-022678-86s3u7dl 135 9 disturbance disturbance NN cord-022678-86s3u7dl 135 10 persisting persist VBG cord-022678-86s3u7dl 135 11 beyond beyond IN cord-022678-86s3u7dl 135 12 the the DT cord-022678-86s3u7dl 135 13 first first JJ cord-022678-86s3u7dl 135 14 postnatal postnatal JJ cord-022678-86s3u7dl 135 15 day day NN cord-022678-86s3u7dl 135 16 at at IN cord-022678-86s3u7dl 135 17 Groote Groote NNP cord-022678-86s3u7dl 135 18 Schuur Schuur NNP cord-022678-86s3u7dl 135 19 Hospital Hospital NNP cord-022678-86s3u7dl 135 20 over over IN cord-022678-86s3u7dl 135 21 a a DT cord-022678-86s3u7dl 135 22 1 1 CD cord-022678-86s3u7dl 135 23 year year NN cord-022678-86s3u7dl 135 24 period period NN cord-022678-86s3u7dl 135 25 underwent undergo VBD cord-022678-86s3u7dl 135 26 formal formal JJ cord-022678-86s3u7dl 135 27 ophthalmological ophthalmological JJ cord-022678-86s3u7dl 135 28 review review NN cord-022678-86s3u7dl 135 29 . . . cord-022678-86s3u7dl 136 1 Twenty twenty CD cord-022678-86s3u7dl 136 2 - - HYPH cord-022678-86s3u7dl 136 3 two two CD cord-022678-86s3u7dl 136 4 pre pre JJ cord-022678-86s3u7dl 136 5 - - JJ cord-022678-86s3u7dl 136 6 eclamptic eclamptic JJ cord-022678-86s3u7dl 136 7 women woman NNS cord-022678-86s3u7dl 136 8 required require VBD cord-022678-86s3u7dl 136 9 ophthalmological ophthalmological JJ cord-022678-86s3u7dl 136 10 assessment assessment NN cord-022678-86s3u7dl 136 11 for for IN cord-022678-86s3u7dl 136 12 persisting persist VBG cord-022678-86s3u7dl 136 13 visual visual JJ cord-022678-86s3u7dl 136 14 disturbance disturbance NN cord-022678-86s3u7dl 136 15 postpartum postpartum NN cord-022678-86s3u7dl 136 16 . . . cord-022678-86s3u7dl 137 1 All all DT cord-022678-86s3u7dl 137 2 women woman NNS cord-022678-86s3u7dl 137 3 had have VBD cord-022678-86s3u7dl 137 4 severe severe JJ cord-022678-86s3u7dl 137 5 pre pre JJ cord-022678-86s3u7dl 137 6 - - JJ cord-022678-86s3u7dl 137 7 eclampsia eclampsia JJ cord-022678-86s3u7dl 137 8 with with IN cord-022678-86s3u7dl 137 9 at at RB cord-022678-86s3u7dl 137 10 least least JJS cord-022678-86s3u7dl 137 11 3 3 CD cord-022678-86s3u7dl 137 12 + + SYM cord-022678-86s3u7dl 137 13 proteinuria proteinuria NN cord-022678-86s3u7dl 137 14 Australian australian JJ cord-022678-86s3u7dl 137 15 and and CC cord-022678-86s3u7dl 137 16 New New NNP cord-022678-86s3u7dl 137 17 Zealand Zealand NNP cord-022678-86s3u7dl 137 18 Journal Journal NNP cord-022678-86s3u7dl 137 19 of of IN cord-022678-86s3u7dl 137 20 Obstetrics Obstetrics NNP cord-022678-86s3u7dl 137 21 and and CC cord-022678-86s3u7dl 137 22 Gynaecology Gynaecology NNP cord-022678-86s3u7dl 137 23 2004 2004 CD cord-022678-86s3u7dl 137 24 ; ; : cord-022678-86s3u7dl 137 25 44 44 CD cord-022678-86s3u7dl 137 26 : : SYM cord-022678-86s3u7dl 137 27 177 177 CD cord-022678-86s3u7dl 137 28 -181 -181 NN cord-022678-86s3u7dl 137 29 and and CC cord-022678-86s3u7dl 137 30 a a DT cord-022678-86s3u7dl 137 31 mean mean JJ cord-022678-86s3u7dl 137 32 highest high JJS cord-022678-86s3u7dl 137 33 antenatal antenatal JJ cord-022678-86s3u7dl 137 34 blood blood NN cord-022678-86s3u7dl 137 35 pressure pressure NN cord-022678-86s3u7dl 137 36 of of IN cord-022678-86s3u7dl 137 37 192/120 192/120 CD cord-022678-86s3u7dl 137 38 . . . cord-022678-86s3u7dl 138 1 Twentyone Twentyone NNP cord-022678-86s3u7dl 138 2 ( ( -LRB- cord-022678-86s3u7dl 138 3 95.5 95.5 CD cord-022678-86s3u7dl 138 4 % % NN cord-022678-86s3u7dl 138 5 ) ) -RRB- cord-022678-86s3u7dl 139 1 women woman NNS cord-022678-86s3u7dl 139 2 had have VBD cord-022678-86s3u7dl 139 3 an an DT cord-022678-86s3u7dl 139 4 abnormality abnormality NN cord-022678-86s3u7dl 139 5 identified identify VBN cord-022678-86s3u7dl 139 6 at at IN cord-022678-86s3u7dl 139 7 fundoscopy fundoscopy NNP cord-022678-86s3u7dl 139 8 or or CC cord-022678-86s3u7dl 139 9 CT CT NNP cord-022678-86s3u7dl 139 10 scan scan NN cord-022678-86s3u7dl 139 11 . . . cord-022678-86s3u7dl 140 1 Seventeen seventeen CD cord-022678-86s3u7dl 140 2 ( ( -LRB- cord-022678-86s3u7dl 140 3 77.3 77.3 CD cord-022678-86s3u7dl 140 4 % % NN cord-022678-86s3u7dl 140 5 ) ) -RRB- cord-022678-86s3u7dl 141 1 women woman NNS cord-022678-86s3u7dl 141 2 had have VBD cord-022678-86s3u7dl 141 3 exudative exudative JJ cord-022678-86s3u7dl 141 4 serous serous JJ cord-022678-86s3u7dl 141 5 retinal retinal JJ cord-022678-86s3u7dl 141 6 detachments detachment NNS cord-022678-86s3u7dl 141 7 ( ( -LRB- cord-022678-86s3u7dl 141 8 10 10 CD cord-022678-86s3u7dl 141 9 of of IN cord-022678-86s3u7dl 141 10 which which WDT cord-022678-86s3u7dl 141 11 were be VBD cord-022678-86s3u7dl 141 12 bilateral bilateral JJ cord-022678-86s3u7dl 141 13 ) ) -RRB- cord-022678-86s3u7dl 141 14 . . . cord-022678-86s3u7dl 142 1 Eight eight CD cord-022678-86s3u7dl 142 2 ( ( -LRB- cord-022678-86s3u7dl 142 3 36.4 36.4 CD cord-022678-86s3u7dl 142 4 % % NN cord-022678-86s3u7dl 142 5 ) ) -RRB- cord-022678-86s3u7dl 143 1 women woman NNS cord-022678-86s3u7dl 143 2 had have VBD cord-022678-86s3u7dl 143 3 Elshnig Elshnig NNP cord-022678-86s3u7dl 143 4 's 's POS cord-022678-86s3u7dl 143 5 spots spot NNS cord-022678-86s3u7dl 143 6 ( ( -LRB- cord-022678-86s3u7dl 143 7 ischaemic ischaemic JJ cord-022678-86s3u7dl 143 8 infarcts infarct NNS cord-022678-86s3u7dl 143 9 in in IN cord-022678-86s3u7dl 143 10 the the DT cord-022678-86s3u7dl 143 11 choroid choroid NN cord-022678-86s3u7dl 143 12 ) ) -RRB- cord-022678-86s3u7dl 143 13 . . . cord-022678-86s3u7dl 144 1 All all PDT cord-022678-86s3u7dl 144 2 those those DT cord-022678-86s3u7dl 144 3 with with IN cord-022678-86s3u7dl 144 4 Elshnig Elshnig NNP cord-022678-86s3u7dl 144 5 's 's POS cord-022678-86s3u7dl 144 6 spots spot NNS cord-022678-86s3u7dl 144 7 had have VBD cord-022678-86s3u7dl 144 8 retinal retinal JJ cord-022678-86s3u7dl 144 9 detachments detachment NNS cord-022678-86s3u7dl 144 10 . . . cord-022678-86s3u7dl 145 1 Three three CD cord-022678-86s3u7dl 145 2 ( ( -LRB- cord-022678-86s3u7dl 145 3 13.6 13.6 CD cord-022678-86s3u7dl 145 4 % % NN cord-022678-86s3u7dl 145 5 ) ) -RRB- cord-022678-86s3u7dl 145 6 women woman NNS cord-022678-86s3u7dl 145 7 had have VBD cord-022678-86s3u7dl 145 8 parieto parieto NNP cord-022678-86s3u7dl 145 9 - - HYPH cord-022678-86s3u7dl 145 10 occipital occipital JJ cord-022678-86s3u7dl 145 11 infarcts infarct NNS cord-022678-86s3u7dl 145 12 identified identify VBN cord-022678-86s3u7dl 145 13 on on IN cord-022678-86s3u7dl 145 14 CT CT NNP cord-022678-86s3u7dl 145 15 scan scan NN cord-022678-86s3u7dl 145 16 . . . cord-022678-86s3u7dl 146 1 One one CD cord-022678-86s3u7dl 146 2 patient patient NN cord-022678-86s3u7dl 146 3 had have VBD cord-022678-86s3u7dl 146 4 cortical cortical JJ cord-022678-86s3u7dl 146 5 blindness blindness NN cord-022678-86s3u7dl 146 6 and and CC cord-022678-86s3u7dl 146 7 one one CD cord-022678-86s3u7dl 146 8 had have VBD cord-022678-86s3u7dl 146 9 optic optic JJ cord-022678-86s3u7dl 146 10 atrophy atrophy NN cord-022678-86s3u7dl 146 11 . . . cord-022678-86s3u7dl 147 1 Fundoscopically fundoscopically RB cord-022678-86s3u7dl 147 2 defined define VBD cord-022678-86s3u7dl 147 3 retinal retinal JJ cord-022678-86s3u7dl 147 4 abnormality abnormality NN cord-022678-86s3u7dl 147 5 occurs occur VBZ cord-022678-86s3u7dl 147 6 in in IN cord-022678-86s3u7dl 147 7 most most JJS cord-022678-86s3u7dl 147 8 pre pre JJ cord-022678-86s3u7dl 147 9 - - JJ cord-022678-86s3u7dl 147 10 eclamptic eclamptic JJ cord-022678-86s3u7dl 147 11 women woman NNS cord-022678-86s3u7dl 147 12 with with IN cord-022678-86s3u7dl 147 13 visual visual JJ cord-022678-86s3u7dl 147 14 disturbances disturbance NNS cord-022678-86s3u7dl 147 15 persisting persist VBG cord-022678-86s3u7dl 147 16 beyond beyond IN cord-022678-86s3u7dl 147 17 the the DT cord-022678-86s3u7dl 147 18 first first JJ cord-022678-86s3u7dl 147 19 postnatal postnatal JJ cord-022678-86s3u7dl 147 20 day day NN cord-022678-86s3u7dl 147 21 . . . cord-022678-86s3u7dl 148 1 The the DT cord-022678-86s3u7dl 148 2 most most RBS cord-022678-86s3u7dl 148 3 common common JJ cord-022678-86s3u7dl 148 4 abnormalities abnormality NNS cord-022678-86s3u7dl 148 5 are be VBP cord-022678-86s3u7dl 148 6 exudative exudative JJ cord-022678-86s3u7dl 148 7 serous serous JJ cord-022678-86s3u7dl 148 8 retinal retinal JJ cord-022678-86s3u7dl 148 9 detachment detachment NN cord-022678-86s3u7dl 148 10 , , , cord-022678-86s3u7dl 148 11 which which WDT cord-022678-86s3u7dl 148 12 are be VBP cord-022678-86s3u7dl 148 13 usually usually RB cord-022678-86s3u7dl 148 14 reversible reversible JJ cord-022678-86s3u7dl 148 15 , , , cord-022678-86s3u7dl 148 16 and and CC cord-022678-86s3u7dl 148 17 Elshnig Elshnig NNP cord-022678-86s3u7dl 148 18 's 's POS cord-022678-86s3u7dl 148 19 spots spot NNS cord-022678-86s3u7dl 148 20 . . . cord-022678-86s3u7dl 149 1 These these DT cord-022678-86s3u7dl 149 2 are be VBP cord-022678-86s3u7dl 149 3 both both DT cord-022678-86s3u7dl 149 4 manifestations manifestation NNS cord-022678-86s3u7dl 149 5 of of IN cord-022678-86s3u7dl 149 6 choroidal choroidal JJ cord-022678-86s3u7dl 149 7 ischaemia ischaemia NN cord-022678-86s3u7dl 149 8 . . . cord-022678-86s3u7dl 150 1 Parieto Parieto NNP cord-022678-86s3u7dl 150 2 - - HYPH cord-022678-86s3u7dl 150 3 occipital occipital NNP cord-022678-86s3u7dl 150 4 infarction infarction NN cord-022678-86s3u7dl 150 5 , , , cord-022678-86s3u7dl 150 6 cortical cortical JJ cord-022678-86s3u7dl 150 7 blindness blindness NN cord-022678-86s3u7dl 150 8 and and CC cord-022678-86s3u7dl 150 9 optic optic JJ cord-022678-86s3u7dl 150 10 atrophy atrophy NN cord-022678-86s3u7dl 150 11 can can MD cord-022678-86s3u7dl 150 12 also also RB cord-022678-86s3u7dl 150 13 occur occur VB cord-022678-86s3u7dl 150 14 . . . cord-022678-86s3u7dl 151 1 BLACKBURN BLACKBURN NNP cord-022678-86s3u7dl 151 2 CA CA NNP cord-022678-86s3u7dl 151 3 , , , cord-022678-86s3u7dl 151 4 POWRIE POWRIE NNP cord-022678-86s3u7dl 151 5 RO RO NNP cord-022678-86s3u7dl 151 6 , , , cord-022678-86s3u7dl 151 7 SAUVE SAUVE NNP cord-022678-86s3u7dl 151 8 N N NNP cord-022678-86s3u7dl 151 9 , , , cord-022678-86s3u7dl 151 10 SUNG sung RB cord-022678-86s3u7dl 151 11 J J NNP cord-022678-86s3u7dl 151 12 , , , cord-022678-86s3u7dl 151 13 EIDSON EIDSON NNP cord-022678-86s3u7dl 151 14 E E NNP cord-022678-86s3u7dl 151 15 , , , cord-022678-86s3u7dl 151 16 HENRY HENRY NNP cord-022678-86s3u7dl 151 17 D D NNP cord-022678-86s3u7dl 151 18 and and CC cord-022678-86s3u7dl 151 19 ROSENE ROSENE NNP cord-022678-86s3u7dl 151 20 - - HYPH cord-022678-86s3u7dl 151 21 MONTELLA montella NN cord-022678-86s3u7dl 151 22 K K NNP cord-022678-86s3u7dl 152 1 Like like IN cord-022678-86s3u7dl 152 2 all all DT cord-022678-86s3u7dl 152 3 aspects aspect NNS cord-022678-86s3u7dl 152 4 of of IN cord-022678-86s3u7dl 152 5 healthcare healthcare NN cord-022678-86s3u7dl 152 6 , , , cord-022678-86s3u7dl 152 7 management management NN cord-022678-86s3u7dl 152 8 of of IN cord-022678-86s3u7dl 152 9 pregnancy pregnancy NN cord-022678-86s3u7dl 152 10 induced induce VBN cord-022678-86s3u7dl 152 11 hypertension hypertension NN cord-022678-86s3u7dl 152 12 ( ( -LRB- cord-022678-86s3u7dl 152 13 PIH PIH NNP cord-022678-86s3u7dl 152 14 ) ) -RRB- cord-022678-86s3u7dl 152 15 in in IN cord-022678-86s3u7dl 152 16 hospital hospital NN cord-022678-86s3u7dl 152 17 is be VBZ cord-022678-86s3u7dl 152 18 subject subject JJ cord-022678-86s3u7dl 152 19 to to IN cord-022678-86s3u7dl 152 20 errors error NNS cord-022678-86s3u7dl 152 21 and and CC cord-022678-86s3u7dl 152 22 ineffectiveness ineffectiveness NN cord-022678-86s3u7dl 152 23 . . . cord-022678-86s3u7dl 153 1 We -PRON- PRP cord-022678-86s3u7dl 153 2 conducted conduct VBD cord-022678-86s3u7dl 153 3 process process NN cord-022678-86s3u7dl 153 4 improvement improvement NN cord-022678-86s3u7dl 153 5 strategy strategy NN cord-022678-86s3u7dl 153 6 known know VBN cord-022678-86s3u7dl 153 7 as as IN cord-022678-86s3u7dl 153 8 Failure Failure NNP cord-022678-86s3u7dl 153 9 Mode Mode NNP cord-022678-86s3u7dl 153 10 and and CC cord-022678-86s3u7dl 153 11 Effect Effect NNP cord-022678-86s3u7dl 153 12 Analysis Analysis NNP cord-022678-86s3u7dl 153 13 ( ( -LRB- cord-022678-86s3u7dl 153 14 FMEA FMEA NNP cord-022678-86s3u7dl 153 15 ) ) -RRB- cord-022678-86s3u7dl 153 16 to to TO cord-022678-86s3u7dl 153 17 identify identify VB cord-022678-86s3u7dl 153 18 potential potential JJ cord-022678-86s3u7dl 153 19 problems problem NNS cord-022678-86s3u7dl 153 20 and and CC cord-022678-86s3u7dl 153 21 improve improve VB cord-022678-86s3u7dl 153 22 the the DT cord-022678-86s3u7dl 153 23 management management NN cord-022678-86s3u7dl 153 24 of of IN cord-022678-86s3u7dl 153 25 PIH PIH NNP cord-022678-86s3u7dl 153 26 in in IN cord-022678-86s3u7dl 153 27 our -PRON- PRP$ cord-022678-86s3u7dl 153 28 hospital hospital NN cord-022678-86s3u7dl 153 29 . . . cord-022678-86s3u7dl 154 1 From from IN cord-022678-86s3u7dl 154 2 October October NNP cord-022678-86s3u7dl 154 3 2002 2002 CD cord-022678-86s3u7dl 154 4 a a DT cord-022678-86s3u7dl 154 5 multidisciplinary multidisciplinary JJ cord-022678-86s3u7dl 154 6 team team NN cord-022678-86s3u7dl 154 7 was be VBD cord-022678-86s3u7dl 154 8 formed form VBN cord-022678-86s3u7dl 154 9 to to TO cord-022678-86s3u7dl 154 10 perform perform VB cord-022678-86s3u7dl 154 11 the the DT cord-022678-86s3u7dl 154 12 FMEA FMEA NNP cord-022678-86s3u7dl 154 13 . . . cord-022678-86s3u7dl 155 1 We -PRON- PRP cord-022678-86s3u7dl 155 2 reviewed review VBD cord-022678-86s3u7dl 155 3 all all DT cord-022678-86s3u7dl 155 4 aspects aspect NNS cord-022678-86s3u7dl 155 5 of of IN cord-022678-86s3u7dl 155 6 the the DT cord-022678-86s3u7dl 155 7 process process NN cord-022678-86s3u7dl 155 8 of of IN cord-022678-86s3u7dl 155 9 management management NN cord-022678-86s3u7dl 155 10 of of IN cord-022678-86s3u7dl 155 11 PIH PIH NNP cord-022678-86s3u7dl 155 12 from from IN cord-022678-86s3u7dl 155 13 referral referral NN cord-022678-86s3u7dl 155 14 to to IN cord-022678-86s3u7dl 155 15 hospital hospital NN cord-022678-86s3u7dl 155 16 until until IN cord-022678-86s3u7dl 155 17 discharge discharge NN cord-022678-86s3u7dl 155 18 . . . cord-022678-86s3u7dl 156 1 For for IN cord-022678-86s3u7dl 156 2 each each DT cord-022678-86s3u7dl 156 3 activity activity NN cord-022678-86s3u7dl 156 4 we -PRON- PRP cord-022678-86s3u7dl 156 5 identified identify VBD cord-022678-86s3u7dl 156 6 potential potential JJ cord-022678-86s3u7dl 156 7 problems problem NNS cord-022678-86s3u7dl 156 8 ( ( -LRB- cord-022678-86s3u7dl 156 9 failure failure NN cord-022678-86s3u7dl 156 10 modes mode NNS cord-022678-86s3u7dl 156 11 ) ) -RRB- cord-022678-86s3u7dl 156 12 , , , cord-022678-86s3u7dl 156 13 defined define VBD cord-022678-86s3u7dl 156 14 their -PRON- PRP$ cord-022678-86s3u7dl 156 15 causes cause NNS cord-022678-86s3u7dl 156 16 and and CC cord-022678-86s3u7dl 156 17 surmised surmise VBD cord-022678-86s3u7dl 156 18 the the DT cord-022678-86s3u7dl 156 19 effects effect NNS cord-022678-86s3u7dl 156 20 if if IN cord-022678-86s3u7dl 156 21 failures failure NNS cord-022678-86s3u7dl 156 22 occurred occur VBD cord-022678-86s3u7dl 156 23 . . . cord-022678-86s3u7dl 157 1 Numerical numerical JJ cord-022678-86s3u7dl 157 2 scores score NNS cord-022678-86s3u7dl 157 3 were be VBD cord-022678-86s3u7dl 157 4 assigned assign VBN cord-022678-86s3u7dl 157 5 for for IN cord-022678-86s3u7dl 157 6 the the DT cord-022678-86s3u7dl 157 7 likelihood likelihood NN cord-022678-86s3u7dl 157 8 of of IN cord-022678-86s3u7dl 157 9 failure failure NN cord-022678-86s3u7dl 157 10 occurrence occurrence NN cord-022678-86s3u7dl 157 11 and and CC cord-022678-86s3u7dl 157 12 the the DT cord-022678-86s3u7dl 157 13 severity severity NN cord-022678-86s3u7dl 157 14 of of IN cord-022678-86s3u7dl 157 15 the the DT cord-022678-86s3u7dl 157 16 effects effect NNS cord-022678-86s3u7dl 157 17 . . . cord-022678-86s3u7dl 158 1 These these DT cord-022678-86s3u7dl 158 2 scores score NNS cord-022678-86s3u7dl 158 3 were be VBD cord-022678-86s3u7dl 158 4 multiplied multiply VBN cord-022678-86s3u7dl 158 5 and and CC cord-022678-86s3u7dl 158 6 reported report VBD cord-022678-86s3u7dl 158 7 as as IN cord-022678-86s3u7dl 158 8 a a DT cord-022678-86s3u7dl 158 9 risk risk NN cord-022678-86s3u7dl 158 10 priority priority NN cord-022678-86s3u7dl 158 11 number number NN cord-022678-86s3u7dl 158 12 ( ( -LRB- cord-022678-86s3u7dl 158 13 RPN RPN NNP cord-022678-86s3u7dl 158 14 ) ) -RRB- cord-022678-86s3u7dl 158 15 for for IN cord-022678-86s3u7dl 158 16 each each DT cord-022678-86s3u7dl 158 17 failure failure NN cord-022678-86s3u7dl 158 18 mode mode NN cord-022678-86s3u7dl 158 19 . . . cord-022678-86s3u7dl 159 1 Solutions solution NNS cord-022678-86s3u7dl 159 2 and and CC cord-022678-86s3u7dl 159 3 monitoring monitoring NN cord-022678-86s3u7dl 159 4 plans plan NNS cord-022678-86s3u7dl 159 5 were be VBD cord-022678-86s3u7dl 159 6 developed develop VBN cord-022678-86s3u7dl 159 7 to to TO cord-022678-86s3u7dl 159 8 address address VB cord-022678-86s3u7dl 159 9 the the DT cord-022678-86s3u7dl 159 10 failure failure NN cord-022678-86s3u7dl 159 11 modes mode NNS cord-022678-86s3u7dl 159 12 with with IN cord-022678-86s3u7dl 159 13 the the DT cord-022678-86s3u7dl 159 14 highest high JJS cord-022678-86s3u7dl 159 15 RPNs rpn NNS cord-022678-86s3u7dl 159 16 . . . cord-022678-86s3u7dl 160 1 Four four CD cord-022678-86s3u7dl 160 2 top top JJ cord-022678-86s3u7dl 160 3 areas area NNS cord-022678-86s3u7dl 160 4 needing need VBG cord-022678-86s3u7dl 160 5 improvement improvement NN cord-022678-86s3u7dl 160 6 were be VBD cord-022678-86s3u7dl 160 7 : : : cord-022678-86s3u7dl 160 8 ( ( -LRB- cord-022678-86s3u7dl 160 9 i i NN cord-022678-86s3u7dl 160 10 ) ) -RRB- cord-022678-86s3u7dl 160 11 accuracy accuracy NN cord-022678-86s3u7dl 160 12 of of IN cord-022678-86s3u7dl 160 13 blood blood NN cord-022678-86s3u7dl 160 14 pressure pressure NN cord-022678-86s3u7dl 160 15 measurement measurement NN cord-022678-86s3u7dl 160 16 ; ; : cord-022678-86s3u7dl 160 17 ( ( -LRB- cord-022678-86s3u7dl 160 18 ii ii NN cord-022678-86s3u7dl 160 19 ) ) -RRB- cord-022678-86s3u7dl 160 20 patient patient JJ cord-022678-86s3u7dl 160 21 education education NN cord-022678-86s3u7dl 160 22 ; ; , cord-022678-86s3u7dl 160 23 ( ( -LRB- cord-022678-86s3u7dl 160 24 iii iii NN cord-022678-86s3u7dl 160 25 ) ) -RRB- cord-022678-86s3u7dl 160 26 evaluation evaluation NN cord-022678-86s3u7dl 160 27 of of IN cord-022678-86s3u7dl 160 28 proteinuria proteinuria NN cord-022678-86s3u7dl 160 29 ; ; : cord-022678-86s3u7dl 160 30 and and CC cord-022678-86s3u7dl 160 31 ( ( -LRB- cord-022678-86s3u7dl 160 32 iv iv LS cord-022678-86s3u7dl 160 33 ) ) -RRB- cord-022678-86s3u7dl 160 34 assessment assessment NN cord-022678-86s3u7dl 160 35 and and CC cord-022678-86s3u7dl 160 36 treatment treatment NN cord-022678-86s3u7dl 160 37 of of IN cord-022678-86s3u7dl 160 38 severe severe JJ cord-022678-86s3u7dl 160 39 hypertension hypertension NN cord-022678-86s3u7dl 160 40 . . . cord-022678-86s3u7dl 161 1 Each each DT cord-022678-86s3u7dl 161 2 of of IN cord-022678-86s3u7dl 161 3 these these DT cord-022678-86s3u7dl 161 4 initiatives initiative NNS cord-022678-86s3u7dl 161 5 , , , cord-022678-86s3u7dl 161 6 with with IN cord-022678-86s3u7dl 161 7 the the DT cord-022678-86s3u7dl 161 8 changes change NNS cord-022678-86s3u7dl 161 9 implemented implement VBN cord-022678-86s3u7dl 161 10 and and CC cord-022678-86s3u7dl 161 11 their -PRON- PRP$ cord-022678-86s3u7dl 161 12 monitoring monitoring NN cord-022678-86s3u7dl 161 13 processes process NNS cord-022678-86s3u7dl 161 14 , , , cord-022678-86s3u7dl 161 15 will will MD cord-022678-86s3u7dl 161 16 be be VB cord-022678-86s3u7dl 161 17 described describe VBN cord-022678-86s3u7dl 161 18 . . . cord-022678-86s3u7dl 162 1 The the DT cord-022678-86s3u7dl 162 2 FMEA FMEA NNP cord-022678-86s3u7dl 162 3 is be VBZ cord-022678-86s3u7dl 162 4 a a DT cord-022678-86s3u7dl 162 5 useful useful JJ cord-022678-86s3u7dl 162 6 process process NN cord-022678-86s3u7dl 162 7 for for IN cord-022678-86s3u7dl 162 8 identifying identify VBG cord-022678-86s3u7dl 162 9 and and CC cord-022678-86s3u7dl 162 10 implementing implement VBG cord-022678-86s3u7dl 162 11 institutional institutional JJ cord-022678-86s3u7dl 162 12 change change NN cord-022678-86s3u7dl 162 13 in in IN cord-022678-86s3u7dl 162 14 regards regard NNS cord-022678-86s3u7dl 162 15 to to IN cord-022678-86s3u7dl 162 16 the the DT cord-022678-86s3u7dl 162 17 management management NN cord-022678-86s3u7dl 162 18 of of IN cord-022678-86s3u7dl 162 19 PIH PIH NNP cord-022678-86s3u7dl 162 20 . . . cord-022678-86s3u7dl 163 1 Our -PRON- PRP$ cord-022678-86s3u7dl 163 2 process process NN cord-022678-86s3u7dl 163 3 may may MD cord-022678-86s3u7dl 163 4 serve serve VB cord-022678-86s3u7dl 163 5 as as IN cord-022678-86s3u7dl 163 6 a a DT cord-022678-86s3u7dl 163 7 model model NN cord-022678-86s3u7dl 163 8 initiative initiative NN cord-022678-86s3u7dl 163 9 to to IN cord-022678-86s3u7dl 163 10 other other JJ cord-022678-86s3u7dl 163 11 institutions institution NNS cord-022678-86s3u7dl 163 12 with with IN cord-022678-86s3u7dl 163 13 similar similar JJ cord-022678-86s3u7dl 163 14 needs need NNS cord-022678-86s3u7dl 163 15 . . . cord-022678-86s3u7dl 164 1 Fertility fertility NN cord-022678-86s3u7dl 164 2 returns return VBZ cord-022678-86s3u7dl 164 3 within within IN cord-022678-86s3u7dl 164 4 months month NNS cord-022678-86s3u7dl 164 5 of of IN cord-022678-86s3u7dl 164 6 successful successful JJ cord-022678-86s3u7dl 164 7 liver liver NN cord-022678-86s3u7dl 164 8 transplantation transplantation NN cord-022678-86s3u7dl 164 9 . . . cord-022678-86s3u7dl 165 1 By by IN cord-022678-86s3u7dl 165 2 June June NNP cord-022678-86s3u7dl 165 3 2001 2001 CD cord-022678-86s3u7dl 165 4 approximately approximately RB cord-022678-86s3u7dl 165 5 350 350 CD cord-022678-86s3u7dl 165 6 liver liver NN cord-022678-86s3u7dl 165 7 transplants transplant NNS cord-022678-86s3u7dl 165 8 had have VBD cord-022678-86s3u7dl 165 9 been be VBN cord-022678-86s3u7dl 165 10 performed perform VBN cord-022678-86s3u7dl 165 11 on on IN cord-022678-86s3u7dl 165 12 Australian australian JJ cord-022678-86s3u7dl 165 13 women woman NNS cord-022678-86s3u7dl 165 14 of of IN cord-022678-86s3u7dl 165 15 potentially potentially RB cord-022678-86s3u7dl 165 16 child child NN cord-022678-86s3u7dl 165 17 - - HYPH cord-022678-86s3u7dl 165 18 bearing bear VBG cord-022678-86s3u7dl 165 19 age age NN cord-022678-86s3u7dl 165 20 . . . cord-022678-86s3u7dl 166 1 The the DT cord-022678-86s3u7dl 166 2 course course NN cord-022678-86s3u7dl 166 3 and and CC cord-022678-86s3u7dl 166 4 outcome outcome NN cord-022678-86s3u7dl 166 5 of of IN cord-022678-86s3u7dl 166 6 seven seven CD cord-022678-86s3u7dl 166 7 pregnancies pregnancy NNS cord-022678-86s3u7dl 166 8 in in IN cord-022678-86s3u7dl 166 9 four four CD cord-022678-86s3u7dl 166 10 liver liver NN cord-022678-86s3u7dl 166 11 transplant transplant NN cord-022678-86s3u7dl 166 12 recipients recipient NNS cord-022678-86s3u7dl 166 13 is be VBZ cord-022678-86s3u7dl 166 14 described describe VBN cord-022678-86s3u7dl 166 15 . . . cord-022678-86s3u7dl 167 1 Four four CD cord-022678-86s3u7dl 167 2 of of IN cord-022678-86s3u7dl 167 3 the the DT cord-022678-86s3u7dl 167 4 pregnancies pregnancy NNS cord-022678-86s3u7dl 167 5 in in IN cord-022678-86s3u7dl 167 6 three three CD cord-022678-86s3u7dl 167 7 mothers mother NNS cord-022678-86s3u7dl 167 8 were be VBD cord-022678-86s3u7dl 167 9 complicated complicate VBN cord-022678-86s3u7dl 167 10 by by IN cord-022678-86s3u7dl 167 11 intrahepatic intrahepatic JJ cord-022678-86s3u7dl 167 12 cholestasis cholestasis NN cord-022678-86s3u7dl 167 13 , , , cord-022678-86s3u7dl 167 14 and and CC cord-022678-86s3u7dl 167 15 one one CD cord-022678-86s3u7dl 167 16 pregnancy pregnancy NN cord-022678-86s3u7dl 167 17 was be VBD cord-022678-86s3u7dl 167 18 complicated complicate VBN cord-022678-86s3u7dl 167 19 by by IN cord-022678-86s3u7dl 167 20 acute acute NN cord-022678-86s3u7dl 167 21 on on IN cord-022678-86s3u7dl 167 22 chronic chronic JJ cord-022678-86s3u7dl 167 23 renal renal JJ cord-022678-86s3u7dl 167 24 failure failure NN cord-022678-86s3u7dl 167 25 requiring require VBG cord-022678-86s3u7dl 167 26 dialysis dialysis NN cord-022678-86s3u7dl 167 27 . . . cord-022678-86s3u7dl 168 1 The the DT cord-022678-86s3u7dl 168 2 literature literature NN cord-022678-86s3u7dl 168 3 on on IN cord-022678-86s3u7dl 168 4 pregnancy pregnancy NN cord-022678-86s3u7dl 168 5 outcome outcome NN cord-022678-86s3u7dl 168 6 in in IN cord-022678-86s3u7dl 168 7 liver liver NN cord-022678-86s3u7dl 168 8 transplant transplant NN cord-022678-86s3u7dl 168 9 recipients recipient NNS cord-022678-86s3u7dl 168 10 and and CC cord-022678-86s3u7dl 168 11 the the DT cord-022678-86s3u7dl 168 12 management management NN cord-022678-86s3u7dl 168 13 of of IN cord-022678-86s3u7dl 168 14 acute acute NN cord-022678-86s3u7dl 168 15 on on IN cord-022678-86s3u7dl 168 16 chronic chronic JJ cord-022678-86s3u7dl 168 17 renal renal JJ cord-022678-86s3u7dl 168 18 failure failure NN cord-022678-86s3u7dl 168 19 in in IN cord-022678-86s3u7dl 168 20 pregnancy pregnancy NN cord-022678-86s3u7dl 168 21 is be VBZ cord-022678-86s3u7dl 168 22 discussed discuss VBN cord-022678-86s3u7dl 168 23 . . . cord-022678-86s3u7dl 169 1 Until until IN cord-022678-86s3u7dl 169 2 recently recently RB cord-022678-86s3u7dl 169 3 the the DT cord-022678-86s3u7dl 169 4 diagnosis diagnosis NN cord-022678-86s3u7dl 169 5 of of IN cord-022678-86s3u7dl 169 6 obstetric obstetric JJ cord-022678-86s3u7dl 169 7 cholestasis cholestasis NN cord-022678-86s3u7dl 169 8 ( ( -LRB- cord-022678-86s3u7dl 169 9 OC OC NNP cord-022678-86s3u7dl 169 10 ) ) -RRB- cord-022678-86s3u7dl 169 11 , , , cord-022678-86s3u7dl 169 12 if if IN cord-022678-86s3u7dl 169 13 made make VBN cord-022678-86s3u7dl 169 14 at at RB cord-022678-86s3u7dl 169 15 all all RB cord-022678-86s3u7dl 169 16 , , , cord-022678-86s3u7dl 169 17 was be VBD cord-022678-86s3u7dl 169 18 made make VBN cord-022678-86s3u7dl 169 19 on on IN cord-022678-86s3u7dl 169 20 the the DT cord-022678-86s3u7dl 169 21 basis basis NN cord-022678-86s3u7dl 169 22 of of IN cord-022678-86s3u7dl 169 23 clinical clinical JJ cord-022678-86s3u7dl 169 24 observation observation NN cord-022678-86s3u7dl 169 25 , , , cord-022678-86s3u7dl 169 26 with with IN cord-022678-86s3u7dl 169 27 apparent apparent JJ cord-022678-86s3u7dl 169 28 considerable considerable JJ cord-022678-86s3u7dl 169 29 inaccuracy inaccuracy NN cord-022678-86s3u7dl 169 30 . . . cord-022678-86s3u7dl 170 1 However however RB cord-022678-86s3u7dl 170 2 , , , cord-022678-86s3u7dl 170 3 while while IN cord-022678-86s3u7dl 170 4 the the DT cord-022678-86s3u7dl 170 5 condition condition NN cord-022678-86s3u7dl 170 6 can can MD cord-022678-86s3u7dl 170 7 increase increase VB cord-022678-86s3u7dl 170 8 risk risk NN cord-022678-86s3u7dl 170 9 of of IN cord-022678-86s3u7dl 170 10 perinatal perinatal JJ cord-022678-86s3u7dl 170 11 mortality mortality NN cord-022678-86s3u7dl 170 12 and and CC cord-022678-86s3u7dl 170 13 maternal maternal JJ cord-022678-86s3u7dl 170 14 morbidity morbidity NN cord-022678-86s3u7dl 170 15 , , , cord-022678-86s3u7dl 170 16 the the DT cord-022678-86s3u7dl 170 17 current current JJ cord-022678-86s3u7dl 170 18 treatment treatment NN cord-022678-86s3u7dl 170 19 of of IN cord-022678-86s3u7dl 170 20 Ursodeoxycholic ursodeoxycholic JJ cord-022678-86s3u7dl 170 21 acid acid NN cord-022678-86s3u7dl 170 22 to to TO cord-022678-86s3u7dl 170 23 reduce reduce VB cord-022678-86s3u7dl 170 24 bile bile NN cord-022678-86s3u7dl 170 25 acid acid NN cord-022678-86s3u7dl 170 26 level level NN cord-022678-86s3u7dl 170 27 in in IN cord-022678-86s3u7dl 170 28 blood blood NN cord-022678-86s3u7dl 170 29 , , , cord-022678-86s3u7dl 170 30 involve involve VBP cord-022678-86s3u7dl 170 31 use use NN cord-022678-86s3u7dl 170 32 of of IN cord-022678-86s3u7dl 170 33 this this DT cord-022678-86s3u7dl 170 34 medication medication NN cord-022678-86s3u7dl 170 35 which which WDT cord-022678-86s3u7dl 170 36 is be VBZ cord-022678-86s3u7dl 170 37 said say VBN cord-022678-86s3u7dl 170 38 to to TO cord-022678-86s3u7dl 170 39 be be VB cord-022678-86s3u7dl 170 40 potentially potentially RB cord-022678-86s3u7dl 170 41 teratogenic teratogenic JJ cord-022678-86s3u7dl 170 42 and and CC cord-022678-86s3u7dl 170 43 not not RB cord-022678-86s3u7dl 170 44 licensed licensed JJ cord-022678-86s3u7dl 170 45 for for IN cord-022678-86s3u7dl 170 46 use use NN cord-022678-86s3u7dl 170 47 in in IN cord-022678-86s3u7dl 170 48 pregnancy pregnancy NN cord-022678-86s3u7dl 170 49 . . . cord-022678-86s3u7dl 171 1 Hence hence RB cord-022678-86s3u7dl 171 2 , , , cord-022678-86s3u7dl 171 3 it -PRON- PRP cord-022678-86s3u7dl 171 4 is be VBZ cord-022678-86s3u7dl 171 5 extremely extremely RB cord-022678-86s3u7dl 171 6 desirable desirable JJ cord-022678-86s3u7dl 171 7 to to TO cord-022678-86s3u7dl 171 8 be be VB cord-022678-86s3u7dl 171 9 able able JJ cord-022678-86s3u7dl 171 10 to to TO cord-022678-86s3u7dl 171 11 identify identify VB cord-022678-86s3u7dl 171 12 with with IN cord-022678-86s3u7dl 171 13 accuracy accuracy NN cord-022678-86s3u7dl 171 14 those those DT cord-022678-86s3u7dl 171 15 cases case NNS cord-022678-86s3u7dl 171 16 really really RB cord-022678-86s3u7dl 171 17 need need VBP cord-022678-86s3u7dl 171 18 of of IN cord-022678-86s3u7dl 171 19 such such JJ cord-022678-86s3u7dl 171 20 treatment treatment NN cord-022678-86s3u7dl 171 21 . . . cord-022678-86s3u7dl 172 1 Accordingly accordingly RB cord-022678-86s3u7dl 172 2 , , , cord-022678-86s3u7dl 172 3 we -PRON- PRP cord-022678-86s3u7dl 172 4 are be VBP cord-022678-86s3u7dl 172 5 attempting attempt VBG cord-022678-86s3u7dl 172 6 to to TO cord-022678-86s3u7dl 172 7 identify identify VB cord-022678-86s3u7dl 172 8 a a DT cord-022678-86s3u7dl 172 9 suitable suitable JJ cord-022678-86s3u7dl 172 10 local local JJ cord-022678-86s3u7dl 172 11 protocol protocol NN cord-022678-86s3u7dl 172 12 for for IN cord-022678-86s3u7dl 172 13 management management NN cord-022678-86s3u7dl 172 14 of of IN cord-022678-86s3u7dl 172 15 these these DT cord-022678-86s3u7dl 172 16 . . . cord-022678-86s3u7dl 173 1 We -PRON- PRP cord-022678-86s3u7dl 173 2 have have VBP cord-022678-86s3u7dl 173 3 carried carry VBN cord-022678-86s3u7dl 173 4 out out RP cord-022678-86s3u7dl 173 5 a a DT cord-022678-86s3u7dl 173 6 review review NN cord-022678-86s3u7dl 173 7 of of IN cord-022678-86s3u7dl 173 8 all all DT cord-022678-86s3u7dl 173 9 pregnant pregnant JJ cord-022678-86s3u7dl 173 10 women woman NNS cord-022678-86s3u7dl 173 11 who who WP cord-022678-86s3u7dl 173 12 had have VBD cord-022678-86s3u7dl 173 13 had have VBN cord-022678-86s3u7dl 173 14 serum serum NN cord-022678-86s3u7dl 173 15 total total JJ cord-022678-86s3u7dl 173 16 bile bile NN cord-022678-86s3u7dl 173 17 acid acid NN cord-022678-86s3u7dl 173 18 levels level NNS cord-022678-86s3u7dl 173 19 measured measure VBN cord-022678-86s3u7dl 173 20 during during IN cord-022678-86s3u7dl 173 21 the the DT cord-022678-86s3u7dl 173 22 whole whole NN cord-022678-86s3u7dl 173 23 of of IN cord-022678-86s3u7dl 173 24 2002 2002 CD cord-022678-86s3u7dl 173 25 . . . cord-022678-86s3u7dl 174 1 They -PRON- PRP cord-022678-86s3u7dl 174 2 were be VBD cord-022678-86s3u7dl 174 3 identified identify VBN cord-022678-86s3u7dl 174 4 from from IN cord-022678-86s3u7dl 174 5 the the DT cord-022678-86s3u7dl 174 6 biochemistry biochemistry NN cord-022678-86s3u7dl 174 7 database database NN cord-022678-86s3u7dl 174 8 , , , cord-022678-86s3u7dl 174 9 and and CC cord-022678-86s3u7dl 174 10 individual individual JJ cord-022678-86s3u7dl 174 11 case case NN cord-022678-86s3u7dl 174 12 notes note NNS cord-022678-86s3u7dl 174 13 were be VBD cord-022678-86s3u7dl 174 14 reviewed review VBN cord-022678-86s3u7dl 174 15 . . . cord-022678-86s3u7dl 175 1 An an DT cord-022678-86s3u7dl 175 2 initial initial JJ cord-022678-86s3u7dl 175 3 review review NN cord-022678-86s3u7dl 175 4 was be VBD cord-022678-86s3u7dl 175 5 carried carry VBN cord-022678-86s3u7dl 175 6 out out RP cord-022678-86s3u7dl 175 7 on on IN cord-022678-86s3u7dl 175 8 women woman NNS cord-022678-86s3u7dl 175 9 who who WP cord-022678-86s3u7dl 175 10 had have VBD cord-022678-86s3u7dl 175 11 had have VBN cord-022678-86s3u7dl 175 12 serum serum NN cord-022678-86s3u7dl 175 13 bile bile NN cord-022678-86s3u7dl 175 14 acid acid NN cord-022678-86s3u7dl 175 15 levels level NNS cord-022678-86s3u7dl 175 16 measured measure VBN cord-022678-86s3u7dl 175 17 on on IN cord-022678-86s3u7dl 175 18 one one CD cord-022678-86s3u7dl 175 19 or or CC cord-022678-86s3u7dl 175 20 more more JJR cord-022678-86s3u7dl 175 21 occasions occasion NNS cord-022678-86s3u7dl 175 22 during during IN cord-022678-86s3u7dl 175 23 the the DT cord-022678-86s3u7dl 175 24 last last JJ cord-022678-86s3u7dl 175 25 quarter quarter NN cord-022678-86s3u7dl 175 26 of of IN cord-022678-86s3u7dl 175 27 2002 2002 CD cord-022678-86s3u7dl 175 28 . . . cord-022678-86s3u7dl 176 1 A a DT cord-022678-86s3u7dl 176 2 total total NN cord-022678-86s3u7dl 176 3 of of IN cord-022678-86s3u7dl 176 4 78 78 CD cord-022678-86s3u7dl 176 5 tests test NNS cord-022678-86s3u7dl 176 6 had have VBD cord-022678-86s3u7dl 176 7 been be VBN cord-022678-86s3u7dl 176 8 performed perform VBN cord-022678-86s3u7dl 176 9 on on IN cord-022678-86s3u7dl 176 10 32 32 CD cord-022678-86s3u7dl 176 11 cases case NNS cord-022678-86s3u7dl 176 12 during during IN cord-022678-86s3u7dl 176 13 the the DT cord-022678-86s3u7dl 176 14 period period NN cord-022678-86s3u7dl 176 15 . . . cord-022678-86s3u7dl 177 1 Eighteen eighteen CD cord-022678-86s3u7dl 177 2 cases case NNS cord-022678-86s3u7dl 177 3 were be VBD cord-022678-86s3u7dl 177 4 found find VBN cord-022678-86s3u7dl 177 5 to to TO cord-022678-86s3u7dl 177 6 have have VB cord-022678-86s3u7dl 177 7 levels level NNS cord-022678-86s3u7dl 177 8 within within IN cord-022678-86s3u7dl 177 9 normal normal JJ cord-022678-86s3u7dl 177 10 limits limit NNS cord-022678-86s3u7dl 177 11 , , , cord-022678-86s3u7dl 177 12 four four CD cord-022678-86s3u7dl 177 13 required require VBN cord-022678-86s3u7dl 177 14 Ursodeoxycholic ursodeoxycholic JJ cord-022678-86s3u7dl 177 15 acid acid NN cord-022678-86s3u7dl 177 16 , , , cord-022678-86s3u7dl 177 17 and and CC cord-022678-86s3u7dl 177 18 labour labour NN cord-022678-86s3u7dl 177 19 was be VBD cord-022678-86s3u7dl 177 20 induced induce VBN cord-022678-86s3u7dl 177 21 in in IN cord-022678-86s3u7dl 177 22 three three CD cord-022678-86s3u7dl 177 23 women woman NNS cord-022678-86s3u7dl 177 24 who who WP cord-022678-86s3u7dl 177 25 were be VBD cord-022678-86s3u7dl 177 26 approaching approach VBG cord-022678-86s3u7dl 177 27 term term NN cord-022678-86s3u7dl 177 28 and and CC cord-022678-86s3u7dl 177 29 remained remain VBD cord-022678-86s3u7dl 177 30 symptomatic symptomatic JJ cord-022678-86s3u7dl 178 1 ( ( -LRB- cord-022678-86s3u7dl 178 2 but but CC cord-022678-86s3u7dl 178 3 serum serum NN cord-022678-86s3u7dl 178 4 bile bile NN cord-022678-86s3u7dl 178 5 acid acid NN cord-022678-86s3u7dl 178 6 levels level NNS cord-022678-86s3u7dl 178 7 were be VBD cord-022678-86s3u7dl 178 8 only only RB cord-022678-86s3u7dl 178 9 slightly slightly RB cord-022678-86s3u7dl 178 10 raised raise VBN cord-022678-86s3u7dl 178 11 ) ) -RRB- cord-022678-86s3u7dl 178 12 . . . cord-022678-86s3u7dl 179 1 The the DT cord-022678-86s3u7dl 179 2 remaining remain VBG cord-022678-86s3u7dl 179 3 six six CD cord-022678-86s3u7dl 179 4 cases case NNS cord-022678-86s3u7dl 179 5 resolved resolve VBN cord-022678-86s3u7dl 179 6 spontaneously spontaneously RB cord-022678-86s3u7dl 179 7 , , , cord-022678-86s3u7dl 179 8 with with IN cord-022678-86s3u7dl 179 9 raised raise VBN cord-022678-86s3u7dl 179 10 initial initial JJ cord-022678-86s3u7dl 179 11 bile bile NN cord-022678-86s3u7dl 179 12 acid acid NN cord-022678-86s3u7dl 179 13 levels level NNS cord-022678-86s3u7dl 179 14 falling fall VBG cord-022678-86s3u7dl 179 15 to to IN cord-022678-86s3u7dl 179 16 within within IN cord-022678-86s3u7dl 179 17 normal normal JJ cord-022678-86s3u7dl 179 18 in in IN cord-022678-86s3u7dl 179 19 subsequent subsequent JJ cord-022678-86s3u7dl 179 20 tests test NNS cord-022678-86s3u7dl 179 21 . . . cord-022678-86s3u7dl 180 1 We -PRON- PRP cord-022678-86s3u7dl 180 2 shall shall MD cord-022678-86s3u7dl 180 3 present present VB cord-022678-86s3u7dl 180 4 the the DT cord-022678-86s3u7dl 180 5 outcomes outcome NNS cord-022678-86s3u7dl 180 6 of of IN cord-022678-86s3u7dl 180 7 the the DT cord-022678-86s3u7dl 180 8 review review NN cord-022678-86s3u7dl 180 9 of of IN cord-022678-86s3u7dl 180 10 all all DT cord-022678-86s3u7dl 180 11 2002 2002 CD cord-022678-86s3u7dl 180 12 cases case NNS cord-022678-86s3u7dl 180 13 , , , cord-022678-86s3u7dl 180 14 with with IN cord-022678-86s3u7dl 180 15 reference reference NN cord-022678-86s3u7dl 180 16 to to IN cord-022678-86s3u7dl 180 17 our -PRON- PRP$ cord-022678-86s3u7dl 180 18 own own JJ cord-022678-86s3u7dl 180 19 normal normal JJ cord-022678-86s3u7dl 180 20 range range NN cord-022678-86s3u7dl 180 21 , , , cord-022678-86s3u7dl 180 22 and and CC cord-022678-86s3u7dl 180 23 on on IN cord-022678-86s3u7dl 180 24 the the DT cord-022678-86s3u7dl 180 25 basis basis NN cord-022678-86s3u7dl 180 26 of of IN cord-022678-86s3u7dl 180 27 this this DT cord-022678-86s3u7dl 180 28 , , , cord-022678-86s3u7dl 180 29 we -PRON- PRP cord-022678-86s3u7dl 180 30 shall shall MD cord-022678-86s3u7dl 180 31 make make VB cord-022678-86s3u7dl 180 32 recommendations recommendation NNS cord-022678-86s3u7dl 180 33 for for IN cord-022678-86s3u7dl 180 34 a a DT cord-022678-86s3u7dl 180 35 protocol protocol NN cord-022678-86s3u7dl 180 36 for for IN cord-022678-86s3u7dl 180 37 diagnosis diagnosis NN cord-022678-86s3u7dl 180 38 and and CC cord-022678-86s3u7dl 180 39 management management NN cord-022678-86s3u7dl 180 40 of of IN cord-022678-86s3u7dl 180 41 OC OC NNP cord-022678-86s3u7dl 180 42 , , , cord-022678-86s3u7dl 180 43 with with IN cord-022678-86s3u7dl 180 44 a a DT cord-022678-86s3u7dl 180 45 view view NN cord-022678-86s3u7dl 180 46 to to TO cord-022678-86s3u7dl 180 47 reduce reduce VB cord-022678-86s3u7dl 180 48 perinatal perinatal JJ cord-022678-86s3u7dl 180 49 mortality mortality NN cord-022678-86s3u7dl 180 50 and and CC cord-022678-86s3u7dl 180 51 maternal maternal JJ cord-022678-86s3u7dl 180 52 morbidity morbidity NN cord-022678-86s3u7dl 180 53 . . . cord-022678-86s3u7dl 181 1 Serum serum NN cord-022678-86s3u7dl 181 2 glutathione glutathione NN cord-022678-86s3u7dl 181 3 S s NN cord-022678-86s3u7dl 181 4 - - HYPH cord-022678-86s3u7dl 181 5 transferase transferase NN cord-022678-86s3u7dl 181 6 alpha alpha NN cord-022678-86s3u7dl 181 7 1 1 NNP cord-022678-86s3u7dl 181 8 - - SYM cord-022678-86s3u7dl 181 9 1 1 CD cord-022678-86s3u7dl 181 10 , , , cord-022678-86s3u7dl 181 11 an an DT cord-022678-86s3u7dl 181 12 index index NN cord-022678-86s3u7dl 181 13 of of IN cord-022678-86s3u7dl 181 14 hepatocellular hepatocellular JJ cord-022678-86s3u7dl 181 15 damage damage NN cord-022678-86s3u7dl 181 16 , , , cord-022678-86s3u7dl 181 17 is be VBZ cord-022678-86s3u7dl 181 18 raised raise VBN cord-022678-86s3u7dl 181 19 at at IN cord-022678-86s3u7dl 181 20 24 24 CD cord-022678-86s3u7dl 181 21 weeks week NNS cord-022678-86s3u7dl 181 22 ' ' POS cord-022678-86s3u7dl 181 23 gestation gestation NN cord-022678-86s3u7dl 181 24 in in IN cord-022678-86s3u7dl 181 25 women woman NNS cord-022678-86s3u7dl 181 26 who who WP cord-022678-86s3u7dl 181 27 develop develop VBP cord-022678-86s3u7dl 181 28 obstetric obstetric JJ cord-022678-86s3u7dl 181 29 cholestasis cholestasis NN cord-022678-86s3u7dl 181 30 GIRLING GIRLING NNP cord-022678-86s3u7dl 181 31 J J NNP cord-022678-86s3u7dl 181 32 , , , cord-022678-86s3u7dl 181 33 DANN DANN NNP cord-022678-86s3u7dl 181 34 A A NNP cord-022678-86s3u7dl 181 35 , , , cord-022678-86s3u7dl 181 36 KENYON KENYON NNP cord-022678-86s3u7dl 181 37 A A NNP cord-022678-86s3u7dl 181 38 , , , cord-022678-86s3u7dl 181 39 SEED seed NN cord-022678-86s3u7dl 181 40 P P NNP cord-022678-86s3u7dl 181 41 , , , cord-022678-86s3u7dl 181 42 NELSON NELSON NNP cord-022678-86s3u7dl 181 43 - - HYPH cord-022678-86s3u7dl 181 44 PIERCY PIERCY NNP cord-022678-86s3u7dl 181 45 C C NNP cord-022678-86s3u7dl 181 46 , , , cord-022678-86s3u7dl 181 47 WILLIAMSON WILLIAMSON NNP cord-022678-86s3u7dl 181 48 C C NNP cord-022678-86s3u7dl 181 49 , , , cord-022678-86s3u7dl 181 50 SHENNAN SHENNAN NNP cord-022678-86s3u7dl 181 51 A A NNP cord-022678-86s3u7dl 181 52 and and CC cord-022678-86s3u7dl 181 53 TRIBE TRIBE NNP cord-022678-86s3u7dl 181 54 R R NNP cord-022678-86s3u7dl 181 55 Statement statement NN cord-022678-86s3u7dl 181 56 of of IN cord-022678-86s3u7dl 181 57 Purpose Purpose NNP cord-022678-86s3u7dl 181 58 : : : cord-022678-86s3u7dl 181 59 Glutathione Glutathione NNP cord-022678-86s3u7dl 181 60 S s NN cord-022678-86s3u7dl 181 61 - - HYPH cord-022678-86s3u7dl 181 62 transferase transferase NN cord-022678-86s3u7dl 181 63 alpha alpha NN cord-022678-86s3u7dl 181 64 1 1 NNP cord-022678-86s3u7dl 181 65 - - HYPH cord-022678-86s3u7dl 181 66 1 1 CD cord-022678-86s3u7dl 181 67 ( ( -LRB- cord-022678-86s3u7dl 181 68 GSTA1 GSTA1 NNP cord-022678-86s3u7dl 181 69 - - HYPH cord-022678-86s3u7dl 181 70 1 1 CD cord-022678-86s3u7dl 181 71 ) ) -RRB- cord-022678-86s3u7dl 181 72 is be VBZ cord-022678-86s3u7dl 181 73 a a DT cord-022678-86s3u7dl 181 74 highly highly RB cord-022678-86s3u7dl 181 75 sensitive sensitive JJ cord-022678-86s3u7dl 181 76 and and CC cord-022678-86s3u7dl 181 77 early early JJ cord-022678-86s3u7dl 181 78 indicator indicator NN cord-022678-86s3u7dl 181 79 of of IN cord-022678-86s3u7dl 181 80 hepatocellular hepatocellular JJ cord-022678-86s3u7dl 181 81 damage damage NN cord-022678-86s3u7dl 181 82 . . . cord-022678-86s3u7dl 182 1 To to TO cord-022678-86s3u7dl 182 2 determine determine VB cord-022678-86s3u7dl 182 3 in in IN cord-022678-86s3u7dl 182 4 a a DT cord-022678-86s3u7dl 182 5 longitudinal longitudinal JJ cord-022678-86s3u7dl 182 6 study study NN cord-022678-86s3u7dl 182 7 whether whether IN cord-022678-86s3u7dl 182 8 GSTA1 GSTA1 NNP cord-022678-86s3u7dl 182 9 - - HYPH cord-022678-86s3u7dl 182 10 1 1 CD cord-022678-86s3u7dl 182 11 is be VBZ cord-022678-86s3u7dl 182 12 a a DT cord-022678-86s3u7dl 182 13 useful useful JJ cord-022678-86s3u7dl 182 14 marker marker NN cord-022678-86s3u7dl 182 15 for for IN cord-022678-86s3u7dl 182 16 obstetric obstetric JJ cord-022678-86s3u7dl 182 17 cholestasis cholestasis NN cord-022678-86s3u7dl 182 18 ( ( -LRB- cord-022678-86s3u7dl 182 19 OC OC NNP cord-022678-86s3u7dl 182 20 ) ) -RRB- cord-022678-86s3u7dl 182 21 and and CC cord-022678-86s3u7dl 182 22 whether whether IN cord-022678-86s3u7dl 182 23 it -PRON- PRP cord-022678-86s3u7dl 182 24 distinguishes distinguish VBZ cord-022678-86s3u7dl 182 25 between between IN cord-022678-86s3u7dl 182 26 OC OC NNP cord-022678-86s3u7dl 182 27 and and CC cord-022678-86s3u7dl 182 28 pruritus pruritus NN cord-022678-86s3u7dl 182 29 gravidarum gravidarum NNP cord-022678-86s3u7dl 182 30 ( ( -LRB- cord-022678-86s3u7dl 182 31 PG PG NNP cord-022678-86s3u7dl 182 32 ) ) -RRB- cord-022678-86s3u7dl 182 33 . . . cord-022678-86s3u7dl 183 1 Statement statement NN cord-022678-86s3u7dl 183 2 of of IN cord-022678-86s3u7dl 183 3 method method NN cord-022678-86s3u7dl 183 4 : : : cord-022678-86s3u7dl 184 1 Serum serum NN cord-022678-86s3u7dl 184 2 GSTA1 GSTA1 NNS cord-022678-86s3u7dl 184 3 - - HYPH cord-022678-86s3u7dl 184 4 1 1 CD cord-022678-86s3u7dl 184 5 was be VBD cord-022678-86s3u7dl 184 6 measured measure VBN cord-022678-86s3u7dl 184 7 in in IN cord-022678-86s3u7dl 184 8 54 54 CD cord-022678-86s3u7dl 184 9 women woman NNS cord-022678-86s3u7dl 184 10 who who WP cord-022678-86s3u7dl 184 11 developed develop VBD cord-022678-86s3u7dl 184 12 OC OC NNP cord-022678-86s3u7dl 184 13 at at IN cord-022678-86s3u7dl 184 14 a a DT cord-022678-86s3u7dl 184 15 median median JJ cord-022678-86s3u7dl 184 16 gestation gestation NN cord-022678-86s3u7dl 184 17 of of IN cord-022678-86s3u7dl 184 18 33.7 33.7 CD cord-022678-86s3u7dl 184 19 weeks week NNS cord-022678-86s3u7dl 184 20 ( ( -LRB- cord-022678-86s3u7dl 184 21 range range VBP cord-022678-86s3u7dl 184 22 21 21 CD cord-022678-86s3u7dl 184 23 - - SYM cord-022678-86s3u7dl 184 24 40.7 40.7 CD cord-022678-86s3u7dl 184 25 ) ) -RRB- cord-022678-86s3u7dl 184 26 ( ( -LRB- cord-022678-86s3u7dl 184 27 those those DT cord-022678-86s3u7dl 184 28 on on IN cord-022678-86s3u7dl 184 29 ursodeoxycholic ursodeoxycholic JJ cord-022678-86s3u7dl 184 30 acid acid NN cord-022678-86s3u7dl 184 31 were be VBD cord-022678-86s3u7dl 184 32 excluded exclude VBN cord-022678-86s3u7dl 184 33 ) ) -RRB- cord-022678-86s3u7dl 184 34 ; ; : cord-022678-86s3u7dl 184 35 29 29 CD cord-022678-86s3u7dl 184 36 with with IN cord-022678-86s3u7dl 184 37 PG PG NNP cord-022678-86s3u7dl 184 38 and and CC cord-022678-86s3u7dl 184 39 22 22 CD cord-022678-86s3u7dl 184 40 with with IN cord-022678-86s3u7dl 184 41 normal normal JJ cord-022678-86s3u7dl 184 42 pregnancy pregnancy NN cord-022678-86s3u7dl 184 43 . . . cord-022678-86s3u7dl 185 1 Serum serum NN cord-022678-86s3u7dl 185 2 was be VBD cord-022678-86s3u7dl 185 3 sampled sample VBN cord-022678-86s3u7dl 185 4 at at IN cord-022678-86s3u7dl 185 5 least least RBS cord-022678-86s3u7dl 185 6 three three CD cord-022678-86s3u7dl 185 7 times time NNS cord-022678-86s3u7dl 185 8 between between IN cord-022678-86s3u7dl 185 9 16 16 CD cord-022678-86s3u7dl 185 10 weeks week NNS cord-022678-86s3u7dl 185 11 ' ' POS cord-022678-86s3u7dl 185 12 gestation gestation NN cord-022678-86s3u7dl 185 13 and and CC cord-022678-86s3u7dl 185 14 delivery delivery NN cord-022678-86s3u7dl 185 15 . . . cord-022678-86s3u7dl 186 1 Summary summary NN cord-022678-86s3u7dl 186 2 of of IN cord-022678-86s3u7dl 186 3 Results result NNS cord-022678-86s3u7dl 186 4 : : : cord-022678-86s3u7dl 186 5 GSTA1 gsta1 CD cord-022678-86s3u7dl 186 6 - - HYPH cord-022678-86s3u7dl 186 7 1 1 CD cord-022678-86s3u7dl 186 8 increased increase VBD cord-022678-86s3u7dl 186 9 with with IN cord-022678-86s3u7dl 186 10 gestation gestation NN cord-022678-86s3u7dl 186 11 in in IN cord-022678-86s3u7dl 186 12 the the DT cord-022678-86s3u7dl 186 13 OC OC NNP cord-022678-86s3u7dl 186 14 group group NN cord-022678-86s3u7dl 186 15 ( ( -LRB- cord-022678-86s3u7dl 186 16 but but CC cord-022678-86s3u7dl 186 17 not not RB cord-022678-86s3u7dl 186 18 the the DT cord-022678-86s3u7dl 186 19 other other JJ cord-022678-86s3u7dl 186 20 groups group NNS cord-022678-86s3u7dl 186 21 ) ) -RRB- cord-022678-86s3u7dl 186 22 and and CC cord-022678-86s3u7dl 186 23 was be VBD cord-022678-86s3u7dl 186 24 significantly significantly RB cord-022678-86s3u7dl 186 25 greater great JJR cord-022678-86s3u7dl 186 26 by by IN cord-022678-86s3u7dl 186 27 24 24 CD cord-022678-86s3u7dl 186 28 weeks week NNS cord-022678-86s3u7dl 186 29 ' ' POS cord-022678-86s3u7dl 186 30 gestation gestation NN cord-022678-86s3u7dl 186 31 than than IN cord-022678-86s3u7dl 186 32 in in IN cord-022678-86s3u7dl 186 33 normal normal JJ cord-022678-86s3u7dl 186 34 pregnancy pregnancy NN cord-022678-86s3u7dl 186 35 and and CC cord-022678-86s3u7dl 186 36 PG PG NNP cord-022678-86s3u7dl 186 37 . . . cord-022678-86s3u7dl 187 1 In in IN cord-022678-86s3u7dl 187 2 the the DT cord-022678-86s3u7dl 187 3 OC OC NNP cord-022678-86s3u7dl 187 4 group group NN cord-022678-86s3u7dl 187 5 there there EX cord-022678-86s3u7dl 187 6 was be VBD cord-022678-86s3u7dl 187 7 a a DT cord-022678-86s3u7dl 187 8 highly highly RB cord-022678-86s3u7dl 187 9 significant significant JJ cord-022678-86s3u7dl 187 10 correlation correlation NN cord-022678-86s3u7dl 187 11 ( ( -LRB- cord-022678-86s3u7dl 187 12 P p NN cord-022678-86s3u7dl 187 13 < < XX cord-022678-86s3u7dl 187 14 0.0001 0.0001 CD cord-022678-86s3u7dl 187 15 ) ) -RRB- cord-022678-86s3u7dl 187 16 between between IN cord-022678-86s3u7dl 187 17 GSTA1 gsta1 CD cord-022678-86s3u7dl 187 18 - - SYM cord-022678-86s3u7dl 187 19 1 1 CD cord-022678-86s3u7dl 187 20 level level NN cord-022678-86s3u7dl 187 21 and and CC cord-022678-86s3u7dl 187 22 alanine alanine NN cord-022678-86s3u7dl 187 23 aminotransferase aminotransferase NN cord-022678-86s3u7dl 187 24 ( ( -LRB- cord-022678-86s3u7dl 187 25 Spearman Spearman NNP cord-022678-86s3u7dl 187 26 's 's POS cord-022678-86s3u7dl 187 27 rank rank NN cord-022678-86s3u7dl 187 28 correlation correlation NN cord-022678-86s3u7dl 187 29 : : : cord-022678-86s3u7dl 187 30 r r NN cord-022678-86s3u7dl 187 31 = = SYM cord-022678-86s3u7dl 187 32 0.764 0.764 CD cord-022678-86s3u7dl 187 33 ) ) -RRB- cord-022678-86s3u7dl 187 34 , , , cord-022678-86s3u7dl 187 35 and and CC cord-022678-86s3u7dl 187 36 total total JJ cord-022678-86s3u7dl 187 37 GSTA1 GSTA1 NNS cord-022678-86s3u7dl 187 38 - - HYPH cord-022678-86s3u7dl 187 39 1 1 CD cord-022678-86s3u7dl 187 40 was be VBD cord-022678-86s3u7dl 187 41 not not RB cord-022678-86s3u7dl 187 42 related relate VBN cord-022678-86s3u7dl 187 43 to to IN cord-022678-86s3u7dl 187 44 severity severity NN cord-022678-86s3u7dl 187 45 of of IN cord-022678-86s3u7dl 187 46 pruritus pruritus NN cord-022678-86s3u7dl 187 47 specificity specificity NN cord-022678-86s3u7dl 187 48 81.40 81.40 CD cord-022678-86s3u7dl 187 49 % % NN cord-022678-86s3u7dl 187 50 ( ( -LRB- cord-022678-86s3u7dl 187 51 CI CI NNP cord-022678-86s3u7dl 187 52 : : : cord-022678-86s3u7dl 187 53 66.60 66.60 CD cord-022678-86s3u7dl 187 54 - - HYPH cord-022678-86s3u7dl 187 55 91.61 91.61 CD cord-022678-86s3u7dl 187 56 % % NN cord-022678-86s3u7dl 187 57 ) ) -RRB- cord-022678-86s3u7dl 187 58 , , , cord-022678-86s3u7dl 187 59 positive positive JJ cord-022678-86s3u7dl 187 60 predictive predictive JJ cord-022678-86s3u7dl 187 61 value value NN cord-022678-86s3u7dl 187 62 86.89 86.89 CD cord-022678-86s3u7dl 187 63 % % NN cord-022678-86s3u7dl 188 1 ( ( -LRB- cord-022678-86s3u7dl 188 2 CI CI NNP cord-022678-86s3u7dl 188 3 : : : cord-022678-86s3u7dl 188 4 75.78 75.78 CD cord-022678-86s3u7dl 188 5 - - SYM cord-022678-86s3u7dl 188 6 94.16 94.16 CD cord-022678-86s3u7dl 188 7 % % NN cord-022678-86s3u7dl 188 8 ) ) -RRB- cord-022678-86s3u7dl 188 9 , , , cord-022678-86s3u7dl 188 10 negative negative JJ cord-022678-86s3u7dl 188 11 predictive predictive JJ cord-022678-86s3u7dl 188 12 value value NN cord-022678-86s3u7dl 188 13 77.78 77.78 CD cord-022678-86s3u7dl 188 14 % % NN cord-022678-86s3u7dl 188 15 ( ( -LRB- cord-022678-86s3u7dl 188 16 CI CI NNP cord-022678-86s3u7dl 188 17 : : : cord-022678-86s3u7dl 188 18 62.91 62.91 CD cord-022678-86s3u7dl 188 19 - - SYM cord-022678-86s3u7dl 188 20 88.80 88.80 CD cord-022678-86s3u7dl 188 21 % % NN cord-022678-86s3u7dl 188 22 ) ) -RRB- cord-022678-86s3u7dl 188 23 , , , cord-022678-86s3u7dl 188 24 and and CC cord-022678-86s3u7dl 188 25 the the DT cord-022678-86s3u7dl 188 26 likelihood likelihood NN cord-022678-86s3u7dl 188 27 ratio ratio NN cord-022678-86s3u7dl 188 28 for for IN cord-022678-86s3u7dl 188 29 a a DT cord-022678-86s3u7dl 188 30 positive positive JJ cord-022678-86s3u7dl 188 31 Conclusion conclusion NN cord-022678-86s3u7dl 189 1 : : : cord-022678-86s3u7dl 189 2 This this DT cord-022678-86s3u7dl 189 3 is be VBZ cord-022678-86s3u7dl 189 4 the the DT cord-022678-86s3u7dl 189 5 first first JJ cord-022678-86s3u7dl 189 6 series series NN cord-022678-86s3u7dl 189 7 of of IN cord-022678-86s3u7dl 189 8 GSTA1 GSTA1 NNP cord-022678-86s3u7dl 189 9 - - HYPH cord-022678-86s3u7dl 189 10 1 1 CD cord-022678-86s3u7dl 189 11 measurement measurement NN cord-022678-86s3u7dl 189 12 in in IN cord-022678-86s3u7dl 189 13 OC OC NNP cord-022678-86s3u7dl 189 14 or or CC cord-022678-86s3u7dl 189 15 PG PG NNP cord-022678-86s3u7dl 189 16 . . . cord-022678-86s3u7dl 190 1 GSTA1 GSTA1 NNP cord-022678-86s3u7dl 191 1 -1 -1 NNP cord-022678-86s3u7dl 191 2 is be VBZ cord-022678-86s3u7dl 191 3 a a DT cord-022678-86s3u7dl 191 4 useful useful JJ cord-022678-86s3u7dl 191 5 marker marker NN cord-022678-86s3u7dl 191 6 of of IN cord-022678-86s3u7dl 191 7 liver liver NN cord-022678-86s3u7dl 191 8 dysfunction dysfunction NN cord-022678-86s3u7dl 191 9 in in IN cord-022678-86s3u7dl 191 10 distinguishing distinguish VBG cord-022678-86s3u7dl 191 11 women woman NNS cord-022678-86s3u7dl 191 12 with with IN cord-022678-86s3u7dl 191 13 OC OC NNP cord-022678-86s3u7dl 191 14 from from IN cord-022678-86s3u7dl 191 15 those those DT cord-022678-86s3u7dl 191 16 with with IN cord-022678-86s3u7dl 191 17 PG PG NNP cord-022678-86s3u7dl 191 18 . . . cord-022678-86s3u7dl 192 1 Interactive interactive JJ cord-022678-86s3u7dl 192 2 case case NN cord-022678-86s3u7dl 192 3 presentation presentation NN cord-022678-86s3u7dl 192 4 . . . cord-022678-86s3u7dl 193 1 No no DT cord-022678-86s3u7dl 193 2 abstract abstract JJ cord-022678-86s3u7dl 193 3 available available JJ cord-022678-86s3u7dl 193 4 . . .