id sid tid token lemma pos cord-339854-scb7pz87 1 1 key key NN cord-339854-scb7pz87 1 2 : : : cord-339854-scb7pz87 2 1 cord-339854-scb7pz87 cord-339854-scb7pz87 NNP cord-339854-scb7pz87 2 2 authors author NNS cord-339854-scb7pz87 2 3 : : : cord-339854-scb7pz87 2 4 Overend Overend NNP cord-339854-scb7pz87 2 5 , , , cord-339854-scb7pz87 2 6 Christopher Christopher NNP cord-339854-scb7pz87 2 7 ; ; : cord-339854-scb7pz87 2 8 Yuan Yuan NNP cord-339854-scb7pz87 2 9 , , , cord-339854-scb7pz87 2 10 Lijuan Lijuan NNP cord-339854-scb7pz87 2 11 ; ; : cord-339854-scb7pz87 2 12 Peccoud Peccoud NNP cord-339854-scb7pz87 2 13 , , , cord-339854-scb7pz87 2 14 Jean Jean NNP cord-339854-scb7pz87 2 15 title title NN cord-339854-scb7pz87 2 16 : : : cord-339854-scb7pz87 2 17 The the DT cord-339854-scb7pz87 2 18 synthetic synthetic JJ cord-339854-scb7pz87 2 19 futures future NNS cord-339854-scb7pz87 2 20 of of IN cord-339854-scb7pz87 2 21 vesicular vesicular JJ cord-339854-scb7pz87 2 22 stomatitis stomatitis NN cord-339854-scb7pz87 2 23 virus virus NN cord-339854-scb7pz87 2 24 date date NN cord-339854-scb7pz87 2 25 : : : cord-339854-scb7pz87 2 26 2012 2012 CD cord-339854-scb7pz87 2 27 - - HYPH cord-339854-scb7pz87 2 28 07 07 CD cord-339854-scb7pz87 2 29 - - HYPH cord-339854-scb7pz87 2 30 11 11 CD cord-339854-scb7pz87 2 31 journal journal NN cord-339854-scb7pz87 2 32 : : : cord-339854-scb7pz87 3 1 Trends trend NNS cord-339854-scb7pz87 4 1 Biotechnol Biotechnol NNP cord-339854-scb7pz87 4 2 DOI DOI NNP cord-339854-scb7pz87 4 3 : : : cord-339854-scb7pz87 4 4 10.1016 10.1016 CD cord-339854-scb7pz87 5 1 /j.tibtech.2012.06.002 /j.tibtech.2012.06.002 NFP cord-339854-scb7pz87 5 2 sha sha NNP cord-339854-scb7pz87 5 3 : : : cord-339854-scb7pz87 6 1 249ba2f55de7febffe7785f9b3228c68c2200e44 249ba2f55de7febffe7785f9b3228c68c2200e44 CD cord-339854-scb7pz87 6 2 doc_id doc_id CD cord-339854-scb7pz87 6 3 : : : cord-339854-scb7pz87 6 4 339854 339854 CD cord-339854-scb7pz87 6 5 cord_uid cord_uid NNS cord-339854-scb7pz87 6 6 : : : cord-339854-scb7pz87 6 7 scb7pz87 scb7pz87 ADD cord-339854-scb7pz87 7 1 nan nan NNP cord-339854-scb7pz87 7 2 Recent Recent NNP cord-339854-scb7pz87 7 3 advances advance NNS cord-339854-scb7pz87 7 4 in in IN cord-339854-scb7pz87 7 5 synthetic synthetic JJ cord-339854-scb7pz87 7 6 biology biology NN cord-339854-scb7pz87 7 7 have have VBP cord-339854-scb7pz87 7 8 opened open VBN cord-339854-scb7pz87 7 9 up up RP cord-339854-scb7pz87 7 10 the the DT cord-339854-scb7pz87 7 11 possibility possibility NN cord-339854-scb7pz87 7 12 of of IN cord-339854-scb7pz87 7 13 finely finely RB cord-339854-scb7pz87 7 14 engineering engineer VBG cord-339854-scb7pz87 7 15 viral viral JJ cord-339854-scb7pz87 7 16 genomes genome NNS cord-339854-scb7pz87 7 17 with with IN cord-339854-scb7pz87 7 18 the the DT cord-339854-scb7pz87 7 19 goal goal NN cord-339854-scb7pz87 7 20 to to TO cord-339854-scb7pz87 7 21 understand understand VB cord-339854-scb7pz87 7 22 and and CC cord-339854-scb7pz87 7 23 prevent prevent VB cord-339854-scb7pz87 7 24 viral viral JJ cord-339854-scb7pz87 7 25 diseases disease NNS cord-339854-scb7pz87 7 26 [ [ -LRB- cord-339854-scb7pz87 7 27 1 1 CD cord-339854-scb7pz87 7 28 ] ] -RRB- cord-339854-scb7pz87 7 29 . . . cord-339854-scb7pz87 8 1 Vesicular vesicular JJ cord-339854-scb7pz87 8 2 stomatitis stomatitis NN cord-339854-scb7pz87 8 3 virus virus NN cord-339854-scb7pz87 8 4 ( ( -LRB- cord-339854-scb7pz87 8 5 VSV VSV NNP cord-339854-scb7pz87 8 6 ) ) -RRB- cord-339854-scb7pz87 8 7 is be VBZ cord-339854-scb7pz87 8 8 one one CD cord-339854-scb7pz87 8 9 of of IN cord-339854-scb7pz87 8 10 the the DT cord-339854-scb7pz87 8 11 most most RBS cord-339854-scb7pz87 8 12 promising promising JJ cord-339854-scb7pz87 8 13 viruses virus NNS cord-339854-scb7pz87 8 14 for for IN cord-339854-scb7pz87 8 15 engineering engineering NN cord-339854-scb7pz87 8 16 vaccines vaccine NNS cord-339854-scb7pz87 8 17 and and CC cord-339854-scb7pz87 8 18 oncolytic oncolytic JJ cord-339854-scb7pz87 8 19 therapies therapy NNS cord-339854-scb7pz87 8 20 [ [ -LRB- cord-339854-scb7pz87 8 21 2 2 CD cord-339854-scb7pz87 8 22 ] ] -RRB- cord-339854-scb7pz87 8 23 . . . cord-339854-scb7pz87 9 1 Its -PRON- PRP$ cord-339854-scb7pz87 9 2 genome genome NN cord-339854-scb7pz87 9 3 is be VBZ cord-339854-scb7pz87 9 4 able able JJ cord-339854-scb7pz87 9 5 to to TO cord-339854-scb7pz87 9 6 accept accept VB cord-339854-scb7pz87 9 7 large large JJ cord-339854-scb7pz87 9 8 foreign foreign JJ cord-339854-scb7pz87 9 9 sequences sequence NNS cord-339854-scb7pz87 9 10 ( ( -LRB- cord-339854-scb7pz87 9 11 Figure figure NN cord-339854-scb7pz87 9 12 1 1 CD cord-339854-scb7pz87 9 13 ) ) -RRB- cord-339854-scb7pz87 9 14 . . . cord-339854-scb7pz87 10 1 VSV VSV NNP cord-339854-scb7pz87 10 2 also also RB cord-339854-scb7pz87 10 3 remains remain VBZ cord-339854-scb7pz87 10 4 viable viable JJ cord-339854-scb7pz87 10 5 as as IN cord-339854-scb7pz87 10 6 a a DT cord-339854-scb7pz87 10 7 pseudotyped pseudotyped NNP cord-339854-scb7pz87 10 8 virus virus NN cord-339854-scb7pz87 10 9 ( ( -LRB- cord-339854-scb7pz87 10 10 an an DT cord-339854-scb7pz87 10 11 enveloped envelop VBN cord-339854-scb7pz87 10 12 virus virus NN cord-339854-scb7pz87 10 13 expressing express VBG cord-339854-scb7pz87 10 14 foreign foreign JJ cord-339854-scb7pz87 10 15 glycoproteins glycoprotein NNS cord-339854-scb7pz87 10 16 in in IN cord-339854-scb7pz87 10 17 place place NN cord-339854-scb7pz87 10 18 of of IN cord-339854-scb7pz87 10 19 the the DT cord-339854-scb7pz87 10 20 native native JJ cord-339854-scb7pz87 10 21 surface surface NN cord-339854-scb7pz87 10 22 proteins protein NNS cord-339854-scb7pz87 10 23 ) ) -RRB- cord-339854-scb7pz87 10 24 [ [ -LRB- cord-339854-scb7pz87 10 25 3 3 CD cord-339854-scb7pz87 10 26 ] ] -RRB- cord-339854-scb7pz87 10 27 . . . cord-339854-scb7pz87 11 1 The the DT cord-339854-scb7pz87 11 2 broad broad JJ cord-339854-scb7pz87 11 3 tissue tissue NN cord-339854-scb7pz87 11 4 tropism tropism NN cord-339854-scb7pz87 11 5 allows allow VBZ cord-339854-scb7pz87 11 6 for for IN cord-339854-scb7pz87 11 7 many many JJ cord-339854-scb7pz87 11 8 different different JJ cord-339854-scb7pz87 11 9 routes route NNS cord-339854-scb7pz87 11 10 of of IN cord-339854-scb7pz87 11 11 administration administration NN cord-339854-scb7pz87 11 12 , , , cord-339854-scb7pz87 11 13 such such JJ cord-339854-scb7pz87 11 14 as as IN cord-339854-scb7pz87 11 15 nasal nasal NN cord-339854-scb7pz87 11 16 sprays spray NNS cord-339854-scb7pz87 11 17 or or CC cord-339854-scb7pz87 11 18 intramuscular intramuscular JJ cord-339854-scb7pz87 11 19 injection injection NN cord-339854-scb7pz87 11 20 . . . cord-339854-scb7pz87 12 1 VSV VSV NNP cord-339854-scb7pz87 12 2 can can MD cord-339854-scb7pz87 12 3 be be VB cord-339854-scb7pz87 12 4 reliably reliably RB cord-339854-scb7pz87 12 5 grown grow VBN cord-339854-scb7pz87 12 6 to to IN cord-339854-scb7pz87 12 7 high high JJ cord-339854-scb7pz87 12 8 titers titer NNS cord-339854-scb7pz87 12 9 in in IN cord-339854-scb7pz87 12 10 cell cell NN cord-339854-scb7pz87 12 11 types type NNS cord-339854-scb7pz87 12 12 approved approve VBN cord-339854-scb7pz87 12 13 for for IN cord-339854-scb7pz87 12 14 vaccine vaccine NN cord-339854-scb7pz87 12 15 production production NN cord-339854-scb7pz87 12 16 . . . cord-339854-scb7pz87 13 1 Finally finally RB cord-339854-scb7pz87 13 2 , , , cord-339854-scb7pz87 13 3 negligible negligible JJ cord-339854-scb7pz87 13 4 pre pre JJ cord-339854-scb7pz87 13 5 - - JJ cord-339854-scb7pz87 13 6 existing existing JJ cord-339854-scb7pz87 13 7 immunity immunity NN cord-339854-scb7pz87 13 8 to to IN cord-339854-scb7pz87 13 9 this this DT cord-339854-scb7pz87 13 10 vector vector NN cord-339854-scb7pz87 13 11 exists exist VBZ cord-339854-scb7pz87 13 12 in in IN cord-339854-scb7pz87 13 13 the the DT cord-339854-scb7pz87 13 14 general general JJ cord-339854-scb7pz87 13 15 population population NN cord-339854-scb7pz87 13 16 . . . cord-339854-scb7pz87 14 1 Protection protection NN cord-339854-scb7pz87 14 2 against against IN cord-339854-scb7pz87 14 3 viral viral JJ cord-339854-scb7pz87 14 4 infections infection NNS cord-339854-scb7pz87 14 5 VSV VSV NNP cord-339854-scb7pz87 14 6 - - HYPH cord-339854-scb7pz87 14 7 vectored vectore VBN cord-339854-scb7pz87 14 8 vaccines vaccine NNS cord-339854-scb7pz87 14 9 have have VBP cord-339854-scb7pz87 14 10 been be VBN cord-339854-scb7pz87 14 11 explored explore VBN cord-339854-scb7pz87 14 12 as as IN cord-339854-scb7pz87 14 13 a a DT cord-339854-scb7pz87 14 14 strategy strategy NN cord-339854-scb7pz87 14 15 to to TO cord-339854-scb7pz87 14 16 protect protect VB cord-339854-scb7pz87 14 17 against against IN cord-339854-scb7pz87 14 18 many many JJ cord-339854-scb7pz87 14 19 emerging emerge VBG cord-339854-scb7pz87 14 20 viral viral JJ cord-339854-scb7pz87 14 21 infections infection NNS cord-339854-scb7pz87 14 22 , , , cord-339854-scb7pz87 14 23 exhibiting exhibit VBG cord-339854-scb7pz87 14 24 exceptional exceptional JJ cord-339854-scb7pz87 14 25 safety safety NN cord-339854-scb7pz87 14 26 and and CC cord-339854-scb7pz87 14 27 efficacy efficacy NN cord-339854-scb7pz87 14 28 . . . cord-339854-scb7pz87 15 1 Of of IN cord-339854-scb7pz87 15 2 particular particular JJ cord-339854-scb7pz87 15 3 interest interest NN cord-339854-scb7pz87 15 4 is be VBZ cord-339854-scb7pz87 15 5 a a DT cord-339854-scb7pz87 15 6 study study NN cord-339854-scb7pz87 15 7 in in IN cord-339854-scb7pz87 15 8 which which WDT cord-339854-scb7pz87 15 9 VSV VSV NNP cord-339854-scb7pz87 15 10 expressing express VBG cord-339854-scb7pz87 15 11 the the DT cord-339854-scb7pz87 15 12 H5 H5 NNP cord-339854-scb7pz87 15 13 antigen antigen NN cord-339854-scb7pz87 15 14 from from IN cord-339854-scb7pz87 15 15 highly highly RB cord-339854-scb7pz87 15 16 pathogenic pathogenic JJ cord-339854-scb7pz87 15 17 avian avian JJ cord-339854-scb7pz87 15 18 influenza influenza NN cord-339854-scb7pz87 15 19 induced induce VBN cord-339854-scb7pz87 15 20 sterilizing sterilize VBG cord-339854-scb7pz87 15 21 immunity immunity NN cord-339854-scb7pz87 15 22 against against IN cord-339854-scb7pz87 15 23 heterologous heterologous JJ cord-339854-scb7pz87 15 24 challenge challenge NN cord-339854-scb7pz87 15 25 in in IN cord-339854-scb7pz87 15 26 mice mouse NNS cord-339854-scb7pz87 15 27 [ [ -LRB- cord-339854-scb7pz87 15 28 4 4 CD cord-339854-scb7pz87 15 29 ] ] -RRB- cord-339854-scb7pz87 15 30 . . . cord-339854-scb7pz87 16 1 In in IN cord-339854-scb7pz87 16 2 this this DT cord-339854-scb7pz87 16 3 experiment experiment NN cord-339854-scb7pz87 16 4 , , , cord-339854-scb7pz87 16 5 it -PRON- PRP cord-339854-scb7pz87 16 6 was be VBD cord-339854-scb7pz87 16 7 impossible impossible JJ cord-339854-scb7pz87 16 8 to to TO cord-339854-scb7pz87 16 9 detect detect VB cord-339854-scb7pz87 16 10 challenge challenge NN cord-339854-scb7pz87 16 11 virus virus NN cord-339854-scb7pz87 16 12 in in IN cord-339854-scb7pz87 16 13 lungs lung NNS cord-339854-scb7pz87 16 14 3 3 CD cord-339854-scb7pz87 16 15 days day NNS cord-339854-scb7pz87 16 16 post post JJ cord-339854-scb7pz87 16 17 - - JJ cord-339854-scb7pz87 16 18 challenge challenge NN cord-339854-scb7pz87 16 19 . . . cord-339854-scb7pz87 17 1 One one CD cord-339854-scb7pz87 17 2 study study NN cord-339854-scb7pz87 17 3 vaccinated vaccinate VBN cord-339854-scb7pz87 17 4 and and CC cord-339854-scb7pz87 17 5 challenged challenge VBN cord-339854-scb7pz87 17 6 macaques macaque NNS cord-339854-scb7pz87 17 7 immunocompromised immunocompromise VBN cord-339854-scb7pz87 17 8 by by IN cord-339854-scb7pz87 17 9 simian simian JJ cord-339854-scb7pz87 17 10 - - HYPH cord-339854-scb7pz87 17 11 human human JJ cord-339854-scb7pz87 17 12 immunodeficiency immunodeficiency NN cord-339854-scb7pz87 17 13 virus virus NN cord-339854-scb7pz87 17 14 ( ( -LRB- cord-339854-scb7pz87 17 15 SHIV SHIV NNP cord-339854-scb7pz87 17 16 ) ) -RRB- cord-339854-scb7pz87 17 17 infection infection NN cord-339854-scb7pz87 17 18 [ [ -LRB- cord-339854-scb7pz87 17 19 3 3 CD cord-339854-scb7pz87 17 20 ] ] -RRB- cord-339854-scb7pz87 17 21 . . . cord-339854-scb7pz87 18 1 The the DT cord-339854-scb7pz87 18 2 vaccine vaccine NN cord-339854-scb7pz87 18 3 was be VBD cord-339854-scb7pz87 18 4 well well RB cord-339854-scb7pz87 18 5 tolerated tolerate VBN cord-339854-scb7pz87 18 6 , , , cord-339854-scb7pz87 18 7 and and CC cord-339854-scb7pz87 18 8 protected protect VBD cord-339854-scb7pz87 18 9 67 67 CD cord-339854-scb7pz87 18 10 % % NN cord-339854-scb7pz87 18 11 of of IN cord-339854-scb7pz87 18 12 the the DT cord-339854-scb7pz87 18 13 vaccinated vaccinate VBN cord-339854-scb7pz87 18 14 subjects subject NNS cord-339854-scb7pz87 18 15 from from IN cord-339854-scb7pz87 18 16 lethal lethal JJ cord-339854-scb7pz87 18 17 Zaire Zaire NNP cord-339854-scb7pz87 18 18 Ebola Ebola NNP cord-339854-scb7pz87 18 19 virus virus NN cord-339854-scb7pz87 18 20 ( ( -LRB- cord-339854-scb7pz87 18 21 ZEBOV ZEBOV NNP cord-339854-scb7pz87 18 22 ) ) -RRB- cord-339854-scb7pz87 18 23 challenge challenge NN cord-339854-scb7pz87 18 24 . . . cord-339854-scb7pz87 19 1 All all DT cord-339854-scb7pz87 19 2 unvaccinated unvaccinated JJ cord-339854-scb7pz87 19 3 animals animal NNS cord-339854-scb7pz87 19 4 succumbed succumb VBN cord-339854-scb7pz87 19 5 by by IN cord-339854-scb7pz87 19 6 day day NN cord-339854-scb7pz87 19 7 10 10 CD cord-339854-scb7pz87 19 8 post post JJ cord-339854-scb7pz87 19 9 - - JJ cord-339854-scb7pz87 19 10 challenge challenge NN cord-339854-scb7pz87 19 11 . . . cord-339854-scb7pz87 20 1 Only only RB cord-339854-scb7pz87 20 2 the the DT cord-339854-scb7pz87 20 3 most most RBS cord-339854-scb7pz87 20 4 severely severely RB cord-339854-scb7pz87 20 5 immunocompromised immunocompromised JJ cord-339854-scb7pz87 20 6 vaccinated vaccinated JJ cord-339854-scb7pz87 20 7 subjects subject NNS cord-339854-scb7pz87 20 8 succumbed succumb VBD cord-339854-scb7pz87 20 9 to to IN cord-339854-scb7pz87 20 10 ZEBOV ZEBOV NNP cord-339854-scb7pz87 20 11 challenge challenge NN cord-339854-scb7pz87 20 12 . . . cord-339854-scb7pz87 21 1 This this DT cord-339854-scb7pz87 21 2 demonstrates demonstrate VBZ cord-339854-scb7pz87 21 3 the the DT cord-339854-scb7pz87 21 4 safety safety NN cord-339854-scb7pz87 21 5 and and CC cord-339854-scb7pz87 21 6 efficacy efficacy NN cord-339854-scb7pz87 21 7 potential potential NN cord-339854-scb7pz87 21 8 of of IN cord-339854-scb7pz87 21 9 VSV VSV NNP cord-339854-scb7pz87 21 10 when when WRB cord-339854-scb7pz87 21 11 live live JJ cord-339854-scb7pz87 21 12 virus virus NN cord-339854-scb7pz87 21 13 vaccination vaccination NN cord-339854-scb7pz87 21 14 would would MD cord-339854-scb7pz87 21 15 otherwise otherwise RB cord-339854-scb7pz87 21 16 be be VB cord-339854-scb7pz87 21 17 contraindicated contraindicate VBN cord-339854-scb7pz87 21 18 . . . cord-339854-scb7pz87 22 1 Although although IN cord-339854-scb7pz87 22 2 viral viral JJ cord-339854-scb7pz87 22 3 vectors vector NNS cord-339854-scb7pz87 22 4 are be VBP cord-339854-scb7pz87 22 5 not not RB cord-339854-scb7pz87 22 6 traditionally traditionally RB cord-339854-scb7pz87 22 7 utilized utilize VBN cord-339854-scb7pz87 22 8 for for IN cord-339854-scb7pz87 22 9 vaccination vaccination NN cord-339854-scb7pz87 22 10 against against IN cord-339854-scb7pz87 22 11 bacterial bacterial JJ cord-339854-scb7pz87 22 12 agents agent NNS cord-339854-scb7pz87 22 13 , , , cord-339854-scb7pz87 22 14 they -PRON- PRP cord-339854-scb7pz87 22 15 do do VBP cord-339854-scb7pz87 22 16 have have VB cord-339854-scb7pz87 22 17 the the DT cord-339854-scb7pz87 22 18 potential potential NN cord-339854-scb7pz87 22 19 for for IN cord-339854-scb7pz87 22 20 protection protection NN cord-339854-scb7pz87 22 21 against against IN cord-339854-scb7pz87 22 22 intracellular intracellular JJ cord-339854-scb7pz87 22 23 bacteria bacteria NNS cord-339854-scb7pz87 22 24 . . . cord-339854-scb7pz87 23 1 A a DT cord-339854-scb7pz87 23 2 significant significant JJ cord-339854-scb7pz87 23 3 level level NN cord-339854-scb7pz87 23 4 of of IN cord-339854-scb7pz87 23 5 protection protection NN cord-339854-scb7pz87 23 6 has have VBZ cord-339854-scb7pz87 23 7 been be VBN cord-339854-scb7pz87 23 8 reported report VBN cord-339854-scb7pz87 23 9 against against IN cord-339854-scb7pz87 23 10 challenge challenge NN cord-339854-scb7pz87 23 11 with with IN cord-339854-scb7pz87 23 12 Mycobacterium Mycobacterium NNP cord-339854-scb7pz87 23 13 tuberculosis tuberculosis NN cord-339854-scb7pz87 23 14 in in IN cord-339854-scb7pz87 23 15 mice mouse NNS cord-339854-scb7pz87 23 16 2 2 CD cord-339854-scb7pz87 23 17 weeks week NNS cord-339854-scb7pz87 23 18 post post NN cord-339854-scb7pz87 23 19 - - JJ cord-339854-scb7pz87 23 20 vaccination vaccination JJ cord-339854-scb7pz87 23 21 [ [ -LRB- cord-339854-scb7pz87 23 22 5 5 CD cord-339854-scb7pz87 23 23 ] ] -RRB- cord-339854-scb7pz87 23 24 . . . cord-339854-scb7pz87 24 1 This this DT cord-339854-scb7pz87 24 2 protection protection NN cord-339854-scb7pz87 24 3 coincided coincide VBD cord-339854-scb7pz87 24 4 with with IN cord-339854-scb7pz87 24 5 elevated elevated JJ cord-339854-scb7pz87 24 6 but but CC cord-339854-scb7pz87 24 7 short short RB cord-339854-scb7pz87 24 8 - - HYPH cord-339854-scb7pz87 24 9 lived live VBN cord-339854-scb7pz87 24 10 CD8 CD8 NNP cord-339854-scb7pz87 24 11 + + CC cord-339854-scb7pz87 24 12 T T NNP cord-339854-scb7pz87 24 13 cells cell NNS cord-339854-scb7pz87 24 14 and and CC cord-339854-scb7pz87 24 15 interferon interferon NN cord-339854-scb7pz87 24 16 ( ( -LRB- cord-339854-scb7pz87 24 17 IFN)-gproducing ifn)-gproducing NN cord-339854-scb7pz87 24 18 T t NN cord-339854-scb7pz87 24 19 cells cell NNS cord-339854-scb7pz87 24 20 following follow VBG cord-339854-scb7pz87 24 21 intramuscular intramuscular JJ cord-339854-scb7pz87 24 22 injection injection NN cord-339854-scb7pz87 24 23 . . . cord-339854-scb7pz87 25 1 Even even RB cord-339854-scb7pz87 25 2 more more RBR cord-339854-scb7pz87 25 3 promising promising JJ cord-339854-scb7pz87 25 4 , , , cord-339854-scb7pz87 25 5 recombinant recombinant JJ cord-339854-scb7pz87 25 6 VSV VSV NNP cord-339854-scb7pz87 25 7 expressing express VBG cord-339854-scb7pz87 25 8 a a DT cord-339854-scb7pz87 25 9 secreted secrete VBN cord-339854-scb7pz87 25 10 form form NN cord-339854-scb7pz87 25 11 of of IN cord-339854-scb7pz87 25 12 a a DT cord-339854-scb7pz87 25 13 virulence virulence NN cord-339854-scb7pz87 25 14 factor factor NN cord-339854-scb7pz87 25 15 protein protein NN cord-339854-scb7pz87 25 16 for for IN cord-339854-scb7pz87 25 17 Yersinia Yersinia NNP cord-339854-scb7pz87 25 18 pestis pestis NN cord-339854-scb7pz87 25 19 , , , cord-339854-scb7pz87 25 20 LcrV LcrV NNP cord-339854-scb7pz87 25 21 , , , cord-339854-scb7pz87 25 22 induced induce VBN cord-339854-scb7pz87 25 23 high high JJ cord-339854-scb7pz87 25 24 levels level NNS cord-339854-scb7pz87 25 25 of of IN cord-339854-scb7pz87 25 26 LcrV LcrV NNP cord-339854-scb7pz87 25 27 - - HYPH cord-339854-scb7pz87 25 28 specific specific JJ cord-339854-scb7pz87 25 29 antibodies antibody NNS cord-339854-scb7pz87 25 30 , , , cord-339854-scb7pz87 25 31 protecting protect VBG cord-339854-scb7pz87 25 32 90 90 CD cord-339854-scb7pz87 25 33 % % NN cord-339854-scb7pz87 25 34 of of IN cord-339854-scb7pz87 25 35 the the DT cord-339854-scb7pz87 25 36 mice mouse NNS cord-339854-scb7pz87 25 37 challenged challenge VBN cord-339854-scb7pz87 25 38 with with IN cord-339854-scb7pz87 25 39 10 10 CD cord-339854-scb7pz87 25 40 LD LD NNP cord-339854-scb7pz87 25 41 50 50 CD cord-339854-scb7pz87 25 42 [ [ -LRB- cord-339854-scb7pz87 25 43 6 6 CD cord-339854-scb7pz87 25 44 ] ] -RRB- cord-339854-scb7pz87 25 45 . . . cord-339854-scb7pz87 26 1 Protection protection NN cord-339854-scb7pz87 26 2 against against IN cord-339854-scb7pz87 26 3 cancerous cancerous JJ cord-339854-scb7pz87 26 4 cells cell NNS cord-339854-scb7pz87 27 1 VSV VSV NNP cord-339854-scb7pz87 27 2 is be VBZ cord-339854-scb7pz87 27 3 known know VBN cord-339854-scb7pz87 27 4 to to TO cord-339854-scb7pz87 27 5 be be VB cord-339854-scb7pz87 27 6 exquisitely exquisitely RB cord-339854-scb7pz87 27 7 sensitive sensitive JJ cord-339854-scb7pz87 27 8 to to IN cord-339854-scb7pz87 27 9 IFN IFN NNP cord-339854-scb7pz87 27 10 . . . cord-339854-scb7pz87 28 1 Many many JJ cord-339854-scb7pz87 28 2 cancerous cancerous JJ cord-339854-scb7pz87 28 3 cells cell NNS cord-339854-scb7pz87 28 4 , , , cord-339854-scb7pz87 28 5 unlike unlike IN cord-339854-scb7pz87 28 6 normal normal JJ cord-339854-scb7pz87 28 7 cells cell NNS cord-339854-scb7pz87 28 8 , , , cord-339854-scb7pz87 28 9 are be VBP cord-339854-scb7pz87 28 10 deficient deficient JJ cord-339854-scb7pz87 28 11 in in IN cord-339854-scb7pz87 28 12 their -PRON- PRP$ cord-339854-scb7pz87 28 13 IFN IFN NNP cord-339854-scb7pz87 28 14 responses response NNS cord-339854-scb7pz87 28 15 . . . cord-339854-scb7pz87 29 1 Therefore therefore RB cord-339854-scb7pz87 29 2 , , , cord-339854-scb7pz87 29 3 it -PRON- PRP cord-339854-scb7pz87 29 4 is be VBZ cord-339854-scb7pz87 29 5 possible possible JJ cord-339854-scb7pz87 29 6 for for IN cord-339854-scb7pz87 29 7 VSV VSV NNP cord-339854-scb7pz87 29 8 to to TO cord-339854-scb7pz87 29 9 kill kill VB cord-339854-scb7pz87 29 10 tumor tumor NN cord-339854-scb7pz87 29 11 cells cell NNS cord-339854-scb7pz87 29 12 , , , cord-339854-scb7pz87 29 13 leaving leave VBG cord-339854-scb7pz87 29 14 healthy healthy JJ cord-339854-scb7pz87 29 15 tissue tissue NN cord-339854-scb7pz87 29 16 at at IN cord-339854-scb7pz87 29 17 tumor tumor NN cord-339854-scb7pz87 29 18 margins margin NNS cord-339854-scb7pz87 29 19 unharmed unharmed JJ cord-339854-scb7pz87 29 20 . . . cord-339854-scb7pz87 30 1 VSV VSV NNP cord-339854-scb7pz87 30 2 is be VBZ cord-339854-scb7pz87 30 3 highly highly RB cord-339854-scb7pz87 30 4 immunogenic immunogenic JJ cord-339854-scb7pz87 30 5 , , , cord-339854-scb7pz87 30 6 therefore therefore RB cord-339854-scb7pz87 30 7 , , , cord-339854-scb7pz87 30 8 it -PRON- PRP cord-339854-scb7pz87 30 9 can can MD cord-339854-scb7pz87 30 10 be be VB cord-339854-scb7pz87 30 11 detected detect VBN cord-339854-scb7pz87 30 12 and and CC cord-339854-scb7pz87 30 13 neutralized neutralize VBN cord-339854-scb7pz87 30 14 by by IN cord-339854-scb7pz87 30 15 the the DT cord-339854-scb7pz87 30 16 immune immune JJ cord-339854-scb7pz87 30 17 system system NN cord-339854-scb7pz87 30 18 before before IN cord-339854-scb7pz87 30 19 tumors tumor NNS cord-339854-scb7pz87 30 20 are be VBP cord-339854-scb7pz87 30 21 sufficiently sufficiently RB cord-339854-scb7pz87 30 22 destroyed destroy VBN cord-339854-scb7pz87 30 23 . . . cord-339854-scb7pz87 31 1 Introducing introduce VBG cord-339854-scb7pz87 31 2 the the DT cord-339854-scb7pz87 31 3 antiinflammatory antiinflammatory JJ cord-339854-scb7pz87 31 4 glycoprotein glycoprotein NN cord-339854-scb7pz87 31 5 from from IN cord-339854-scb7pz87 31 6 equine equine JJ cord-339854-scb7pz87 31 7 herpesvirus herpesvirus NN cord-339854-scb7pz87 31 8 1 1 CD cord-339854-scb7pz87 31 9 into into IN cord-339854-scb7pz87 31 10 the the DT cord-339854-scb7pz87 31 11 VSV VSV NNP cord-339854-scb7pz87 31 12 genome genome NN cord-339854-scb7pz87 31 13 helped help VBD cord-339854-scb7pz87 31 14 the the DT cord-339854-scb7pz87 31 15 virus virus NN cord-339854-scb7pz87 31 16 to to TO cord-339854-scb7pz87 31 17 replicate replicate VB cord-339854-scb7pz87 31 18 more more RBR cord-339854-scb7pz87 31 19 effectively effectively RB cord-339854-scb7pz87 31 20 in in IN cord-339854-scb7pz87 31 21 a a DT cord-339854-scb7pz87 31 22 rat rat NN cord-339854-scb7pz87 31 23 model model NN cord-339854-scb7pz87 31 24 of of IN cord-339854-scb7pz87 31 25 hepatocellular hepatocellular JJ cord-339854-scb7pz87 31 26 carcinoma carcinoma NN cord-339854-scb7pz87 31 27 [ [ -LRB- cord-339854-scb7pz87 31 28 7 7 CD cord-339854-scb7pz87 31 29 ] ] -RRB- cord-339854-scb7pz87 31 30 . . . cord-339854-scb7pz87 32 1 This this DT cord-339854-scb7pz87 32 2 resulted result VBD cord-339854-scb7pz87 32 3 in in IN cord-339854-scb7pz87 32 4 a a DT cord-339854-scb7pz87 32 5 significant significant JJ cord-339854-scb7pz87 32 6 increase increase NN cord-339854-scb7pz87 32 7 of of IN cord-339854-scb7pz87 32 8 the the DT cord-339854-scb7pz87 32 9 area area NN cord-339854-scb7pz87 32 10 of of IN cord-339854-scb7pz87 32 11 necrotic necrotic JJ cord-339854-scb7pz87 32 12 cells cell NNS cord-339854-scb7pz87 32 13 within within IN cord-339854-scb7pz87 32 14 the the DT cord-339854-scb7pz87 32 15 tumor tumor NN cord-339854-scb7pz87 32 16 . . . cord-339854-scb7pz87 33 1 It -PRON- PRP cord-339854-scb7pz87 33 2 also also RB cord-339854-scb7pz87 33 3 increased increase VBD cord-339854-scb7pz87 33 4 the the DT cord-339854-scb7pz87 33 5 survival survival NN cord-339854-scb7pz87 33 6 of of IN cord-339854-scb7pz87 33 7 the the DT cord-339854-scb7pz87 33 8 animals animal NNS cord-339854-scb7pz87 33 9 . . . cord-339854-scb7pz87 34 1 The the DT cord-339854-scb7pz87 34 2 safety safety NN cord-339854-scb7pz87 34 3 of of IN cord-339854-scb7pz87 34 4 VSV VSV NNP cord-339854-scb7pz87 34 5 has have VBZ cord-339854-scb7pz87 34 6 been be VBN cord-339854-scb7pz87 34 7 demonstrated demonstrate VBN cord-339854-scb7pz87 34 8 in in IN cord-339854-scb7pz87 34 9 immunocompromised immunocompromised JJ cord-339854-scb7pz87 34 10 macaques macaque NNS cord-339854-scb7pz87 34 11 [ [ -LRB- cord-339854-scb7pz87 34 12 3 3 CD cord-339854-scb7pz87 34 13 ] ] -RRB- cord-339854-scb7pz87 34 14 . . . cord-339854-scb7pz87 35 1 The the DT cord-339854-scb7pz87 35 2 neurovirulence neurovirulence NN cord-339854-scb7pz87 35 3 observed observe VBD cord-339854-scb7pz87 35 4 in in IN cord-339854-scb7pz87 35 5 some some DT cord-339854-scb7pz87 35 6 VSV VSV NNP cord-339854-scb7pz87 35 7 infections infection NNS cord-339854-scb7pz87 35 8 has have VBZ cord-339854-scb7pz87 35 9 been be VBN cord-339854-scb7pz87 35 10 a a DT cord-339854-scb7pz87 35 11 source source NN cord-339854-scb7pz87 35 12 of of IN cord-339854-scb7pz87 35 13 concern concern NN cord-339854-scb7pz87 35 14 . . . cord-339854-scb7pz87 36 1 However however RB cord-339854-scb7pz87 36 2 , , , cord-339854-scb7pz87 36 3 researchers researcher NNS cord-339854-scb7pz87 36 4 have have VBP cord-339854-scb7pz87 36 5 identified identify VBN cord-339854-scb7pz87 36 6 mutations mutation NNS cord-339854-scb7pz87 36 7 erasing erase VBG cord-339854-scb7pz87 36 8 neurological neurological JJ cord-339854-scb7pz87 36 9 signs sign NNS cord-339854-scb7pz87 36 10 [ [ -LRB- cord-339854-scb7pz87 36 11 8 8 CD cord-339854-scb7pz87 36 12 , , , cord-339854-scb7pz87 36 13 9 9 CD cord-339854-scb7pz87 36 14 ] ] -RRB- cord-339854-scb7pz87 36 15 . . . cord-339854-scb7pz87 37 1 Surprisingly surprisingly RB cord-339854-scb7pz87 37 2 , , , cord-339854-scb7pz87 37 3 it -PRON- PRP cord-339854-scb7pz87 37 4 has have VBZ cord-339854-scb7pz87 37 5 also also RB cord-339854-scb7pz87 37 6 been be VBN cord-339854-scb7pz87 37 7 demonstrated demonstrate VBN cord-339854-scb7pz87 37 8 that that IN cord-339854-scb7pz87 37 9 a a DT cord-339854-scb7pz87 37 10 replication replication NN cord-339854-scb7pz87 37 11 - - HYPH cord-339854-scb7pz87 37 12 deficient deficient JJ cord-339854-scb7pz87 37 13 vector vector NN cord-339854-scb7pz87 37 14 may may MD cord-339854-scb7pz87 37 15 be be VB cord-339854-scb7pz87 37 16 a a DT cord-339854-scb7pz87 37 17 more more RBR cord-339854-scb7pz87 37 18 potent potent JJ cord-339854-scb7pz87 37 19 vaccine vaccine NN cord-339854-scb7pz87 37 20 than than IN cord-339854-scb7pz87 37 21 a a DT cord-339854-scb7pz87 37 22 replication replication NN cord-339854-scb7pz87 37 23 - - HYPH cord-339854-scb7pz87 37 24 competent competent JJ cord-339854-scb7pz87 37 25 one one CD cord-339854-scb7pz87 37 26 [ [ -LRB- cord-339854-scb7pz87 37 27 10 10 CD cord-339854-scb7pz87 37 28 ] ] -RRB- cord-339854-scb7pz87 37 29 . . . cord-339854-scb7pz87 38 1 This this DT cord-339854-scb7pz87 38 2 observation observation NN cord-339854-scb7pz87 38 3 addresses address VBZ cord-339854-scb7pz87 38 4 many many JJ cord-339854-scb7pz87 38 5 safety safety NN cord-339854-scb7pz87 38 6 issues issue NNS cord-339854-scb7pz87 38 7 related relate VBN cord-339854-scb7pz87 38 8 to to IN cord-339854-scb7pz87 38 9 the the DT cord-339854-scb7pz87 38 10 use use NN cord-339854-scb7pz87 38 11 of of IN cord-339854-scb7pz87 38 12 replicating replicate VBG cord-339854-scb7pz87 38 13 viruses virus NNS cord-339854-scb7pz87 38 14 . . . cord-339854-scb7pz87 39 1 A a DT cord-339854-scb7pz87 39 2 more more RBR cord-339854-scb7pz87 39 3 significant significant JJ cord-339854-scb7pz87 39 4 milestone milestone NN cord-339854-scb7pz87 39 5 is be VBZ cord-339854-scb7pz87 39 6 the the DT cord-339854-scb7pz87 39 7 start start NN cord-339854-scb7pz87 39 8 of of IN cord-339854-scb7pz87 39 9 the the DT cord-339854-scb7pz87 39 10 first first JJ cord-339854-scb7pz87 39 11 clinical clinical JJ cord-339854-scb7pz87 39 12 trials trial NNS cord-339854-scb7pz87 39 13 of of IN cord-339854-scb7pz87 39 14 vaccines vaccine NNS cord-339854-scb7pz87 39 15 derived derive VBN cord-339854-scb7pz87 39 16 from from IN cord-339854-scb7pz87 39 17 VSV VSV NNP cord-339854-scb7pz87 39 18 . . . cord-339854-scb7pz87 40 1 Two two CD cord-339854-scb7pz87 40 2 clinical clinical JJ cord-339854-scb7pz87 40 3 trials trial NNS cord-339854-scb7pz87 40 4 are be VBP cord-339854-scb7pz87 40 5 recruiting recruit VBG cord-339854-scb7pz87 40 6 healthy healthy JJ cord-339854-scb7pz87 40 7 , , , cord-339854-scb7pz87 40 8 HIV HIV NNP cord-339854-scb7pz87 40 9 - - HYPH cord-339854-scb7pz87 40 10 free free JJ cord-339854-scb7pz87 40 11 volunteers volunteer NNS cord-339854-scb7pz87 40 12 to to TO cord-339854-scb7pz87 40 13 examine examine VB cord-339854-scb7pz87 40 14 the the DT cord-339854-scb7pz87 40 15 safety safety NN cord-339854-scb7pz87 40 16 of of IN cord-339854-scb7pz87 40 17 potential potential JJ cord-339854-scb7pz87 40 18 HIV HIV NNP cord-339854-scb7pz87 40 19 vaccines vaccine NNS cord-339854-scb7pz87 40 20 . . . cord-339854-scb7pz87 41 1 These these DT cord-339854-scb7pz87 41 2 Phase Phase NNP cord-339854-scb7pz87 41 3 I -PRON- PRP cord-339854-scb7pz87 41 4 studies study NNS cord-339854-scb7pz87 41 5 will will MD cord-339854-scb7pz87 41 6 use use VB cord-339854-scb7pz87 41 7 either either CC cord-339854-scb7pz87 41 8 VSV VSV NNP cord-339854-scb7pz87 41 9 expressing express VBG cord-339854-scb7pz87 41 10 the the DT cord-339854-scb7pz87 41 11 HIV HIV NNP cord-339854-scb7pz87 41 12 Gag Gag NNP cord-339854-scb7pz87 41 13 protein protein NN cord-339854-scb7pz87 41 14 as as IN cord-339854-scb7pz87 41 15 a a DT cord-339854-scb7pz87 41 16 primary primary JJ cord-339854-scb7pz87 41 17 vaccine vaccine NN cord-339854-scb7pz87 41 18 ( ( -LRB- cord-339854-scb7pz87 41 19 ClinicalTrials.gov ClinicalTrials.gov NNP cord-339854-scb7pz87 41 20 identifier identifier NN cord-339854-scb7pz87 41 21 : : : cord-339854-scb7pz87 41 22 NCT01438606 NCT01438606 NNP cord-339854-scb7pz87 41 23 ) ) -RRB- cord-339854-scb7pz87 41 24 , , , cord-339854-scb7pz87 41 25 or or CC cord-339854-scb7pz87 41 26 VSV VSV NNP cord-339854-scb7pz87 41 27 - - HYPH cord-339854-scb7pz87 41 28 HIV HIV NNP cord-339854-scb7pz87 41 29 Gag Gag NNP cord-339854-scb7pz87 41 30 as as IN cord-339854-scb7pz87 41 31 a a DT cord-339854-scb7pz87 41 32 booster booster NN cord-339854-scb7pz87 41 33 to to IN cord-339854-scb7pz87 41 34 primary primary JJ cord-339854-scb7pz87 41 35 vaccination vaccination NN cord-339854-scb7pz87 41 36 with with IN cord-339854-scb7pz87 41 37 DNA dna NN cord-339854-scb7pz87 41 38 expressing express VBG cord-339854-scb7pz87 41 39 HIV HIV NNP cord-339854-scb7pz87 41 40 Gag Gag NNP cord-339854-scb7pz87 41 41 and and CC cord-339854-scb7pz87 41 42 interleukin-12 interleukin-12 VBZ cord-339854-scb7pz87 41 43 as as IN cord-339854-scb7pz87 41 44 an an DT cord-339854-scb7pz87 41 45 adjuvant adjuvant NN cord-339854-scb7pz87 41 46 ( ( -LRB- cord-339854-scb7pz87 41 47 ClinicalTrials.gov ClinicalTrials.gov NNP cord-339854-scb7pz87 41 48 identifier identifier NN cord-339854-scb7pz87 41 49 : : : cord-339854-scb7pz87 41 50 NCT01578889 NCT01578889 NNP cord-339854-scb7pz87 41 51 ) ) -RRB- cord-339854-scb7pz87 41 52 . . . cord-339854-scb7pz87 42 1 Successes success NNS cord-339854-scb7pz87 42 2 of of IN cord-339854-scb7pz87 42 3 these these DT cord-339854-scb7pz87 42 4 trials trial NNS cord-339854-scb7pz87 42 5 will will MD cord-339854-scb7pz87 42 6 dramatically dramatically RB cord-339854-scb7pz87 42 7 increase increase VB cord-339854-scb7pz87 42 8 the the DT cord-339854-scb7pz87 42 9 viability viability NN cord-339854-scb7pz87 42 10 of of IN cord-339854-scb7pz87 42 11 VSV VSV NNP cord-339854-scb7pz87 42 12 derivatives derivative NNS cord-339854-scb7pz87 42 13 in in IN cord-339854-scb7pz87 42 14 clinical clinical JJ cord-339854-scb7pz87 42 15 applications application NNS cord-339854-scb7pz87 42 16 . . . cord-339854-scb7pz87 43 1 In in IN cord-339854-scb7pz87 43 2 light light NN cord-339854-scb7pz87 43 3 of of IN cord-339854-scb7pz87 43 4 promising promising JJ cord-339854-scb7pz87 43 5 successes success NNS cord-339854-scb7pz87 43 6 in in IN cord-339854-scb7pz87 43 7 a a DT cord-339854-scb7pz87 43 8 wide wide JJ cord-339854-scb7pz87 43 9 variety variety NN cord-339854-scb7pz87 43 10 of of IN cord-339854-scb7pz87 43 11 laboratory laboratory NN cord-339854-scb7pz87 43 12 studies study NNS cord-339854-scb7pz87 43 13 , , , cord-339854-scb7pz87 43 14 it -PRON- PRP cord-339854-scb7pz87 43 15 seems seem VBZ cord-339854-scb7pz87 43 16 as as IN cord-339854-scb7pz87 43 17 though though IN cord-339854-scb7pz87 43 18 VSV VSV NNP cord-339854-scb7pz87 43 19 will will MD cord-339854-scb7pz87 43 20 become become VB cord-339854-scb7pz87 43 21 a a DT cord-339854-scb7pz87 43 22 chassis chassis NN cord-339854-scb7pz87 43 23 of of IN cord-339854-scb7pz87 43 24 choice choice NN cord-339854-scb7pz87 43 25 for for IN cord-339854-scb7pz87 43 26 engineering engineer VBG cord-339854-scb7pz87 43 27 therapeutic therapeutic JJ cord-339854-scb7pz87 43 28 viruses virus NNS cord-339854-scb7pz87 43 29 targeting target VBG cord-339854-scb7pz87 43 30 a a DT cord-339854-scb7pz87 43 31 broad broad JJ cord-339854-scb7pz87 43 32 range range NN cord-339854-scb7pz87 43 33 of of IN cord-339854-scb7pz87 43 34 diseases disease NNS cord-339854-scb7pz87 43 35 . . . cord-339854-scb7pz87 44 1 The the DT cord-339854-scb7pz87 44 2 genome genome NN cord-339854-scb7pz87 44 3 is be VBZ cord-339854-scb7pz87 44 4 small small JJ cord-339854-scb7pz87 44 5 enough enough RB cord-339854-scb7pz87 44 6 to to TO cord-339854-scb7pz87 44 7 be be VB cord-339854-scb7pz87 44 8 manipulated manipulate VBN cord-339854-scb7pz87 44 9 in in IN cord-339854-scb7pz87 44 10 bacterial bacterial JJ cord-339854-scb7pz87 44 11 plasmids plasmid NNS cord-339854-scb7pz87 44 12 . . . cord-339854-scb7pz87 45 1 Its -PRON- PRP$ cord-339854-scb7pz87 45 2 structure structure NN cord-339854-scb7pz87 45 3 is be VBZ cord-339854-scb7pz87 45 4 simple simple JJ cord-339854-scb7pz87 45 5 enough enough RB cord-339854-scb7pz87 45 6 to to TO cord-339854-scb7pz87 45 7 be be VB cord-339854-scb7pz87 45 8 modeled model VBN cord-339854-scb7pz87 45 9 using use VBG cord-339854-scb7pz87 45 10 Computer Computer NNP cord-339854-scb7pz87 45 11 Assisted Assisted NNP cord-339854-scb7pz87 45 12 Design Design NNP cord-339854-scb7pz87 45 13 software software NN cord-339854-scb7pz87 45 14 applications application NNS cord-339854-scb7pz87 45 15 for for IN cord-339854-scb7pz87 45 16 synthetic synthetic JJ cord-339854-scb7pz87 45 17 biology biology NN cord-339854-scb7pz87 45 18 . . . cord-339854-scb7pz87 46 1 For for IN cord-339854-scb7pz87 46 2 instance instance NN cord-339854-scb7pz87 46 3 , , , cord-339854-scb7pz87 46 4 GenoCAD GenoCAD NNP cord-339854-scb7pz87 46 5 [ [ -LRB- cord-339854-scb7pz87 46 6 11 11 CD cord-339854-scb7pz87 46 7 ] ] -RRB- cord-339854-scb7pz87 46 8 was be VBD cord-339854-scb7pz87 46 9 used use VBN cord-339854-scb7pz87 46 10 to to TO cord-339854-scb7pz87 46 11 generate generate VB cord-339854-scb7pz87 46 12 the the DT cord-339854-scb7pz87 46 13 logical logical JJ cord-339854-scb7pz87 46 14 representations representation NNS cord-339854-scb7pz87 46 15 of of IN cord-339854-scb7pz87 46 16 the the DT cord-339854-scb7pz87 46 17 therapeutic therapeutic JJ cord-339854-scb7pz87 46 18 viruses virus NNS cord-339854-scb7pz87 46 19 reviewed review VBN cord-339854-scb7pz87 46 20 in in IN cord-339854-scb7pz87 46 21 this this DT cord-339854-scb7pz87 46 22 letter letter NN cord-339854-scb7pz87 46 23 ( ( -LRB- cord-339854-scb7pz87 46 24 Figure figure NN cord-339854-scb7pz87 46 25 1 1 CD cord-339854-scb7pz87 46 26 ) ) -RRB- cord-339854-scb7pz87 46 27 . . . cord-339854-scb7pz87 47 1 The the DT cord-339854-scb7pz87 47 2 coalescence coalescence NN cord-339854-scb7pz87 47 3 of of IN cord-339854-scb7pz87 47 4 progress progress NN cord-339854-scb7pz87 47 5 in in IN cord-339854-scb7pz87 47 6 synthetic synthetic JJ cord-339854-scb7pz87 47 7 biology biology NN cord-339854-scb7pz87 47 8 Similarly similarly RB cord-339854-scb7pz87 47 9 , , , cord-339854-scb7pz87 47 10 a a DT cord-339854-scb7pz87 47 11 severe severe JJ cord-339854-scb7pz87 47 12 acute acute JJ cord-339854-scb7pz87 47 13 respiratory respiratory JJ cord-339854-scb7pz87 47 14 syndrome syndrome NN cord-339854-scb7pz87 47 15 ( ( -LRB- cord-339854-scb7pz87 47 16 SARS SARS NNP cord-339854-scb7pz87 47 17 ) ) -RRB- cord-339854-scb7pz87 47 18 vaccine vaccine NN cord-339854-scb7pz87 47 19 was be VBD cord-339854-scb7pz87 47 20 designed design VBN cord-339854-scb7pz87 47 21 by by IN cord-339854-scb7pz87 47 22 replacing replace VBG cord-339854-scb7pz87 47 23 the the DT cord-339854-scb7pz87 47 24 VSV VSV NNP cord-339854-scb7pz87 47 25 G G NNP cord-339854-scb7pz87 47 26 protein protein NN cord-339854-scb7pz87 47 27 with with IN cord-339854-scb7pz87 47 28 the the DT cord-339854-scb7pz87 47 29 SARS SARS NNP cord-339854-scb7pz87 47 30 spike spike NN cord-339854-scb7pz87 47 31 ( ( -LRB- cord-339854-scb7pz87 47 32 S s NN cord-339854-scb7pz87 47 33 ) ) -RRB- cord-339854-scb7pz87 47 34 protein protein NN cord-339854-scb7pz87 47 35 ( ( -LRB- cord-339854-scb7pz87 47 36 c c NN cord-339854-scb7pz87 47 37 ) ) -RRB- cord-339854-scb7pz87 47 38 . . . cord-339854-scb7pz87 48 1 The the DT cord-339854-scb7pz87 48 2 avian avian JJ cord-339854-scb7pz87 48 3 influenza influenza NN cord-339854-scb7pz87 48 4 vaccine vaccine NN cord-339854-scb7pz87 48 5 relies rely VBZ cord-339854-scb7pz87 48 6 on on IN cord-339854-scb7pz87 48 7 the the DT cord-339854-scb7pz87 48 8 insertion insertion NN cord-339854-scb7pz87 48 9 of of IN cord-339854-scb7pz87 48 10 a a DT cord-339854-scb7pz87 48 11 sequence sequence NN cord-339854-scb7pz87 48 12 coding code VBG cord-339854-scb7pz87 48 13 for for IN cord-339854-scb7pz87 48 14 the the DT cord-339854-scb7pz87 48 15 H5 H5 NNP cord-339854-scb7pz87 48 16 antigen antigen NN cord-339854-scb7pz87 48 17 immediately immediately RB cord-339854-scb7pz87 48 18 next next RB cord-339854-scb7pz87 48 19 to to IN cord-339854-scb7pz87 48 20 the the DT cord-339854-scb7pz87 48 21 leader leader NN cord-339854-scb7pz87 48 22 sequence sequence NN cord-339854-scb7pz87 48 23 ( ( -LRB- cord-339854-scb7pz87 48 24 d d NN cord-339854-scb7pz87 48 25 ) ) -RRB- cord-339854-scb7pz87 48 26 . . . cord-339854-scb7pz87 49 1 Interestingly interestingly RB cord-339854-scb7pz87 49 2 , , , cord-339854-scb7pz87 49 3 the the DT cord-339854-scb7pz87 49 4 booster booster NN cord-339854-scb7pz87 49 5 vaccine vaccine NN cord-339854-scb7pz87 49 6 carries carry VBZ cord-339854-scb7pz87 49 7 a a DT cord-339854-scb7pz87 49 8 different different JJ cord-339854-scb7pz87 49 9 variant variant NN cord-339854-scb7pz87 49 10 of of IN cord-339854-scb7pz87 49 11 the the DT cord-339854-scb7pz87 49 12 VSV VSV NNP cord-339854-scb7pz87 49 13 G G NNP cord-339854-scb7pz87 49 14 protein protein NN cord-339854-scb7pz87 49 15 to to TO cord-339854-scb7pz87 49 16 escape escape VB cord-339854-scb7pz87 49 17 the the DT cord-339854-scb7pz87 49 18 anti anti JJ cord-339854-scb7pz87 49 19 - - JJ cord-339854-scb7pz87 49 20 VSV VSV NNP cord-339854-scb7pz87 49 21 immune immune JJ cord-339854-scb7pz87 49 22 response response NN cord-339854-scb7pz87 49 23 acquired acquire VBN cord-339854-scb7pz87 49 24 during during IN cord-339854-scb7pz87 49 25 the the DT cord-339854-scb7pz87 49 26 primary primary JJ cord-339854-scb7pz87 49 27 immunization immunization NN cord-339854-scb7pz87 49 28 . . . cord-339854-scb7pz87 50 1 The the DT cord-339854-scb7pz87 50 2 tuberculosis tuberculosis NN cord-339854-scb7pz87 50 3 vaccine vaccine NN cord-339854-scb7pz87 50 4 relies rely VBZ cord-339854-scb7pz87 50 5 on on IN cord-339854-scb7pz87 50 6 the the DT cord-339854-scb7pz87 50 7 insertion insertion NN cord-339854-scb7pz87 50 8 of of IN cord-339854-scb7pz87 50 9 an an DT cord-339854-scb7pz87 50 10 antigen antigen NN cord-339854-scb7pz87 50 11 between between IN cord-339854-scb7pz87 50 12 G G NNP cord-339854-scb7pz87 50 13 and and CC cord-339854-scb7pz87 50 14 L l NN cord-339854-scb7pz87 50 15 ( ( -LRB- cord-339854-scb7pz87 50 16 e e NN cord-339854-scb7pz87 50 17 ) ) -RRB- cord-339854-scb7pz87 50 18 . . . cord-339854-scb7pz87 51 1 The the DT cord-339854-scb7pz87 51 2 Yersinia Yersinia NNP cord-339854-scb7pz87 51 3 pestis pestis NN cord-339854-scb7pz87 51 4 vaccine vaccine NN cord-339854-scb7pz87 51 5 is be VBZ cord-339854-scb7pz87 51 6 structurally structurally RB cord-339854-scb7pz87 51 7 comparable comparable JJ cord-339854-scb7pz87 51 8 to to IN cord-339854-scb7pz87 51 9 the the DT cord-339854-scb7pz87 51 10 avian avian JJ cord-339854-scb7pz87 51 11 influenza influenza NN cord-339854-scb7pz87 51 12 vaccine vaccine NN cord-339854-scb7pz87 51 13 ( ( -LRB- cord-339854-scb7pz87 51 14 f f NNP cord-339854-scb7pz87 51 15 ) ) -RRB- cord-339854-scb7pz87 51 16 . . . cord-339854-scb7pz87 52 1 Finally finally RB cord-339854-scb7pz87 52 2 , , , cord-339854-scb7pz87 52 3 the the DT cord-339854-scb7pz87 52 4 anti anti JJ cord-339854-scb7pz87 52 5 - - JJ cord-339854-scb7pz87 52 6 inflammatory inflammatory JJ cord-339854-scb7pz87 52 7 oncolytic oncolytic JJ cord-339854-scb7pz87 52 8 VSV VSV NNP cord-339854-scb7pz87 52 9 has have VBZ cord-339854-scb7pz87 52 10 a a DT cord-339854-scb7pz87 52 11 large large JJ cord-339854-scb7pz87 52 12 insert insert NN cord-339854-scb7pz87 52 13 between between IN cord-339854-scb7pz87 52 14 G g NN cord-339854-scb7pz87 52 15 and and CC cord-339854-scb7pz87 52 16 L. L. NNP cord-339854-scb7pz87 53 1 The the DT cord-339854-scb7pz87 53 2 insert insert NN cord-339854-scb7pz87 53 3 includes include VBZ cord-339854-scb7pz87 53 4 an an DT cord-339854-scb7pz87 53 5 anti anti JJ cord-339854-scb7pz87 53 6 - - JJ cord-339854-scb7pz87 53 7 inflammatory inflammatory JJ cord-339854-scb7pz87 53 8 glycoprotein glycoprotein NN cord-339854-scb7pz87 53 9 ( ( -LRB- cord-339854-scb7pz87 53 10 EHV1 EHV1 NNP cord-339854-scb7pz87 53 11 G G NNP cord-339854-scb7pz87 53 12 ) ) -RRB- cord-339854-scb7pz87 53 13 and and CC cord-339854-scb7pz87 53 14 a a DT cord-339854-scb7pz87 53 15 reporter reporter NN cord-339854-scb7pz87 53 16 gene gene NN cord-339854-scb7pz87 53 17 ( ( -LRB- cord-339854-scb7pz87 53 18 Luc Luc NNP cord-339854-scb7pz87 53 19 ) ) -RRB- cord-339854-scb7pz87 53 20 separated separate VBN cord-339854-scb7pz87 53 21 by by IN cord-339854-scb7pz87 53 22 an an DT cord-339854-scb7pz87 53 23 internal internal JJ cord-339854-scb7pz87 53 24 ribosome ribosome NN cord-339854-scb7pz87 53 25 entry entry NN cord-339854-scb7pz87 53 26 site site NN cord-339854-scb7pz87 53 27 ( ( -LRB- cord-339854-scb7pz87 53 28 IRES IRES NNP cord-339854-scb7pz87 53 29 ) ) -RRB- cord-339854-scb7pz87 53 30 ( ( -LRB- cord-339854-scb7pz87 53 31 g g NN cord-339854-scb7pz87 53 32 ) ) -RRB- cord-339854-scb7pz87 53 33 . . . cord-339854-scb7pz87 54 1 These these DT cord-339854-scb7pz87 54 2 logical logical JJ cord-339854-scb7pz87 54 3 maps map NNS cord-339854-scb7pz87 54 4 were be VBD cord-339854-scb7pz87 54 5 generated generate VBN cord-339854-scb7pz87 54 6 using use VBG cord-339854-scb7pz87 54 7 GenoCAD GenoCAD NNPS cord-339854-scb7pz87 54 8 [ [ -LRB- cord-339854-scb7pz87 54 9 11 11 CD cord-339854-scb7pz87 54 10 ] ] -RRB- cord-339854-scb7pz87 54 11 . . . cord-339854-scb7pz87 55 1 Trends trend NNS cord-339854-scb7pz87 55 2 in in IN cord-339854-scb7pz87 55 3 Biotechnology Biotechnology NNP cord-339854-scb7pz87 55 4 October October NNP cord-339854-scb7pz87 55 5 2012 2012 CD cord-339854-scb7pz87 55 6 , , , cord-339854-scb7pz87 55 7 Vol Vol NNP cord-339854-scb7pz87 55 8 . . . cord-339854-scb7pz87 56 1 30 30 CD cord-339854-scb7pz87 56 2 , , , cord-339854-scb7pz87 56 3 No no NN cord-339854-scb7pz87 56 4 . . NN cord-339854-scb7pz87 56 5 10 10 CD cord-339854-scb7pz87 56 6 Synthetic synthetic JJ cord-339854-scb7pz87 56 7 viruses virus NNS cord-339854-scb7pz87 56 8 : : : cord-339854-scb7pz87 56 9 a a DT cord-339854-scb7pz87 56 10 new new JJ cord-339854-scb7pz87 56 11 opportunity opportunity NN cord-339854-scb7pz87 56 12 to to TO cord-339854-scb7pz87 56 13 understand understand VB cord-339854-scb7pz87 56 14 and and CC cord-339854-scb7pz87 56 15 prevent prevent VB cord-339854-scb7pz87 56 16 viral viral JJ cord-339854-scb7pz87 56 17 disease disease NN cord-339854-scb7pz87 56 18 Vesicular Vesicular NNP cord-339854-scb7pz87 56 19 stomatitis stomatitis NN cord-339854-scb7pz87 56 20 virus virus NN cord-339854-scb7pz87 56 21 : : : cord-339854-scb7pz87 56 22 re re IN cord-339854-scb7pz87 56 23 - - VBG cord-339854-scb7pz87 56 24 inventing invent VBG cord-339854-scb7pz87 56 25 the the DT cord-339854-scb7pz87 56 26 bullet bullet NN cord-339854-scb7pz87 56 27 Vesicular Vesicular NNP cord-339854-scb7pz87 56 28 stomatitis stomatitis NN cord-339854-scb7pz87 56 29 virus virus NN cord-339854-scb7pz87 56 30 - - HYPH cord-339854-scb7pz87 56 31 based base VBN cord-339854-scb7pz87 56 32 Ebola Ebola NNP cord-339854-scb7pz87 56 33 vaccine vaccine NN cord-339854-scb7pz87 56 34 is be VBZ cord-339854-scb7pz87 56 35 well well RB cord-339854-scb7pz87 56 36 - - HYPH cord-339854-scb7pz87 56 37 tolerated tolerate VBN cord-339854-scb7pz87 56 38 and and CC cord-339854-scb7pz87 56 39 protects protect VBZ cord-339854-scb7pz87 56 40 immunocompromised immunocompromised JJ cord-339854-scb7pz87 56 41 nonhuman nonhuman NN cord-339854-scb7pz87 56 42 primates primate NNS cord-339854-scb7pz87 57 1 Potent potent JJ cord-339854-scb7pz87 57 2 vesicular vesicular JJ cord-339854-scb7pz87 57 3 stomatitis stomatitis NN cord-339854-scb7pz87 57 4 virus virus NN cord-339854-scb7pz87 57 5 - - HYPH cord-339854-scb7pz87 57 6 based base VBN cord-339854-scb7pz87 57 7 avian avian JJ cord-339854-scb7pz87 57 8 influenza influenza NN cord-339854-scb7pz87 57 9 vaccines vaccine NNS cord-339854-scb7pz87 57 10 provide provide VBP cord-339854-scb7pz87 57 11 long long JJ cord-339854-scb7pz87 57 12 - - HYPH cord-339854-scb7pz87 57 13 term term NN cord-339854-scb7pz87 57 14 sterilizing sterilize VBG cord-339854-scb7pz87 57 15 immunity immunity NN cord-339854-scb7pz87 57 16 against against IN cord-339854-scb7pz87 57 17 heterologous heterologous JJ cord-339854-scb7pz87 57 18 challenge challenge NN cord-339854-scb7pz87 58 1 Heterologous Heterologous NNP cord-339854-scb7pz87 58 2 boosting boosting NN cord-339854-scb7pz87 58 3 of of IN cord-339854-scb7pz87 58 4 recombinant recombinant JJ cord-339854-scb7pz87 58 5 adenoviral adenoviral JJ cord-339854-scb7pz87 58 6 prime prime JJ cord-339854-scb7pz87 58 7 immunization immunization NN cord-339854-scb7pz87 58 8 with with IN cord-339854-scb7pz87 58 9 a a DT cord-339854-scb7pz87 58 10 novel novel JJ cord-339854-scb7pz87 58 11 vesicular vesicular JJ cord-339854-scb7pz87 58 12 stomatitis stomatitis NN cord-339854-scb7pz87 58 13 virus virus NN cord-339854-scb7pz87 58 14 - - HYPH cord-339854-scb7pz87 58 15 vectored vectore VBN cord-339854-scb7pz87 58 16 tuberculosis tuberculosis NN cord-339854-scb7pz87 58 17 vaccine vaccine NN cord-339854-scb7pz87 58 18 Single single JJ cord-339854-scb7pz87 58 19 - - HYPH cord-339854-scb7pz87 58 20 dose dose NN cord-339854-scb7pz87 58 21 , , , cord-339854-scb7pz87 58 22 virus virus NN cord-339854-scb7pz87 58 23 - - HYPH cord-339854-scb7pz87 58 24 vectored vectore VBN cord-339854-scb7pz87 58 25 vaccine vaccine NN cord-339854-scb7pz87 58 26 protection protection NN cord-339854-scb7pz87 58 27 against against IN cord-339854-scb7pz87 58 28 Yersinia Yersinia NNP cord-339854-scb7pz87 58 29 pestis pestis NN cord-339854-scb7pz87 58 30 challenge challenge NN cord-339854-scb7pz87 59 1 : : : cord-339854-scb7pz87 59 2 CD4(+ cd4(+ LS cord-339854-scb7pz87 59 3 ) ) -RRB- cord-339854-scb7pz87 59 4 cells cell NNS cord-339854-scb7pz87 59 5 are be VBP cord-339854-scb7pz87 59 6 required require VBN cord-339854-scb7pz87 59 7 at at IN cord-339854-scb7pz87 59 8 the the DT cord-339854-scb7pz87 59 9 time time NN cord-339854-scb7pz87 59 10 of of IN cord-339854-scb7pz87 59 11 challenge challenge NN cord-339854-scb7pz87 59 12 for for IN cord-339854-scb7pz87 59 13 optimal optimal JJ cord-339854-scb7pz87 59 14 protection protection NN cord-339854-scb7pz87 59 15 Exponential exponential JJ cord-339854-scb7pz87 59 16 enhancement enhancement NN cord-339854-scb7pz87 59 17 of of IN cord-339854-scb7pz87 59 18 oncolytic oncolytic JJ cord-339854-scb7pz87 59 19 vesicular vesicular JJ cord-339854-scb7pz87 59 20 stomatitis stomatitis NN cord-339854-scb7pz87 59 21 virus virus NN cord-339854-scb7pz87 59 22 potency potency NN cord-339854-scb7pz87 59 23 by by IN cord-339854-scb7pz87 59 24 vector vector NN cord-339854-scb7pz87 59 25 - - HYPH cord-339854-scb7pz87 59 26 mediated mediate VBN cord-339854-scb7pz87 59 27 suppression suppression NN cord-339854-scb7pz87 59 28 of of IN cord-339854-scb7pz87 59 29 inflammatory inflammatory JJ cord-339854-scb7pz87 59 30 responses response NNS cord-339854-scb7pz87 59 31 in in IN cord-339854-scb7pz87 59 32 vivo vivo NNP cord-339854-scb7pz87 59 33 Neurovirulence Neurovirulence NNP cord-339854-scb7pz87 59 34 properties property NNS cord-339854-scb7pz87 59 35 of of IN cord-339854-scb7pz87 59 36 recombinant recombinant JJ cord-339854-scb7pz87 59 37 vesicular vesicular JJ cord-339854-scb7pz87 59 38 stomatitis stomatitis NN cord-339854-scb7pz87 59 39 virus virus NN cord-339854-scb7pz87 59 40 vectors vector NNS cord-339854-scb7pz87 59 41 in in IN cord-339854-scb7pz87 59 42 non non JJ cord-339854-scb7pz87 59 43 - - JJ cord-339854-scb7pz87 59 44 human human JJ cord-339854-scb7pz87 59 45 primates primate NNS cord-339854-scb7pz87 59 46 Peripheral peripheral JJ cord-339854-scb7pz87 59 47 immunization immunization NN cord-339854-scb7pz87 59 48 blocks block VBZ cord-339854-scb7pz87 59 49 lethal lethal JJ cord-339854-scb7pz87 59 50 actions action NNS cord-339854-scb7pz87 59 51 of of IN cord-339854-scb7pz87 59 52 vesicular vesicular JJ cord-339854-scb7pz87 59 53 stomatitis stomatitis NN cord-339854-scb7pz87 59 54 virus virus NN cord-339854-scb7pz87 59 55 within within IN cord-339854-scb7pz87 59 56 the the DT cord-339854-scb7pz87 59 57 brain brain NN cord-339854-scb7pz87 60 1 SARS SARS NNP cord-339854-scb7pz87 60 2 vaccine vaccine NN cord-339854-scb7pz87 60 3 based base VBN cord-339854-scb7pz87 60 4 on on IN cord-339854-scb7pz87 60 5 a a DT cord-339854-scb7pz87 60 6 replicationdefective replicationdefective JJ cord-339854-scb7pz87 60 7 recombinant recombinant JJ cord-339854-scb7pz87 60 8 vesicular vesicular JJ cord-339854-scb7pz87 60 9 stomatitis stomatitis NN cord-339854-scb7pz87 60 10 virus virus NN cord-339854-scb7pz87 60 11 is be VBZ cord-339854-scb7pz87 60 12 more more RBR cord-339854-scb7pz87 60 13 potent potent JJ cord-339854-scb7pz87 60 14 than than IN cord-339854-scb7pz87 60 15 one one CD cord-339854-scb7pz87 60 16 based base VBN cord-339854-scb7pz87 60 17 on on IN cord-339854-scb7pz87 60 18 a a DT cord-339854-scb7pz87 60 19 replication replication NN cord-339854-scb7pz87 60 20 - - HYPH cord-339854-scb7pz87 60 21 competent competent JJ cord-339854-scb7pz87 60 22 vector vector NN cord-339854-scb7pz87 60 23 Writing writing NN cord-339854-scb7pz87 60 24 DNA dna NN cord-339854-scb7pz87 60 25 with with IN cord-339854-scb7pz87 60 26 GenoCAD GenoCAD NNS cord-339854-scb7pz87 60 27 ( ( -LRB- cord-339854-scb7pz87 60 28 TM TM NNP cord-339854-scb7pz87 60 29 ) ) -RRB- cord-339854-scb7pz87 61 1 All all DT cord-339854-scb7pz87 61 2 rights right NNS cord-339854-scb7pz87 61 3 reserved reserve VBD cord-339854-scb7pz87 61 4 This this DT cord-339854-scb7pz87 61 5 work work NN cord-339854-scb7pz87 61 6 was be VBD cord-339854-scb7pz87 61 7 funded fund VBN cord-339854-scb7pz87 61 8 by by IN cord-339854-scb7pz87 61 9 National National NNP cord-339854-scb7pz87 61 10 Science Science NNP cord-339854-scb7pz87 61 11 Foundation Foundation NNP cord-339854-scb7pz87 61 12 Award Award NNP cord-339854-scb7pz87 61 13 EF-0850100 EF-0850100 NNP cord-339854-scb7pz87 61 14 and and CC cord-339854-scb7pz87 61 15 a a DT cord-339854-scb7pz87 61 16 seed seed NN cord-339854-scb7pz87 61 17 grant grant NN cord-339854-scb7pz87 61 18 from from IN cord-339854-scb7pz87 61 19 the the DT cord-339854-scb7pz87 61 20 Virginia Virginia NNP cord-339854-scb7pz87 61 21 Tech Tech NNP cord-339854-scb7pz87 61 22 Institute Institute NNP cord-339854-scb7pz87 61 23 for for IN cord-339854-scb7pz87 61 24 Critical Critical NNP cord-339854-scb7pz87 61 25 Technologies Technologies NNPS cord-339854-scb7pz87 61 26 and and CC cord-339854-scb7pz87 61 27 Applied Applied NNP cord-339854-scb7pz87 61 28 Science Science NNP cord-339854-scb7pz87 61 29 . . .