id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267712-mhx8e5y0	Fang, Xinkui	Evaluation of attenuated VSVs with mutated M or/and G proteins as vaccine vectors	2012-02-08		.txt	text/plain	5776	308	57	Due to its potent capabilities in triggering cellular, humoral, and mucosal immunities in animals, even after a single administration, recombinant VSV has been studied as a vaccine vector not only for preventing vesicular stomatitis disease in livestock [4] , but a number of human pathogens including: Influenza virus, Ebola virus, Marburg virus, Human immunodeficiency (HIV) virus, Severe Acute Respiratory Syndrome (SARS) virus, and Hepatitis C virus [5] [6] [7] [8] [9] . In vivo, however, VSV M protein mutant proved to be only moderately attenuated in experimental infections [16, 21] , whereas there is currently no information available if recombinant VSV with truncated G protein is safe or not when animals challenged with high dose of the mutant virus. Based on pathogenicity and capabilities to stimulate potent immune responses, we aimed to identify a suitable recombinant VSV vaccine vector and vaccine candidate for preventing vesicular stomatitis disease.	./cache/cord-267712-mhx8e5y0.txt	./txt/cord-267712-mhx8e5y0.txt