id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003667-u1xa44nw	Rodriguez, Sergio E.	Vesicular Stomatitis Virus-Based Vaccine Protects Mice against Crimean-Congo Hemorrhagic Fever	2019-05-23		.txt	text/plain	8082	409	48	Based on the results of these initial pilot studies, we elected to adjust vaccine and challenge doses, and administered 10 7 pfu/dose of the replication competent virus (ΔGrVSV-CCHFV-GPCΔ) to prime and boosted groups of five STAT-1 −/− mice, respectively (Fig. 3) . Regardless, protection was achieved by both regimens, although the boosted group data suggests that at study endpoint, the observed IgG titers against CCHFV-GPC along with lower neutralizing titers (PRNT 50 of < 1:320) are evidence of the ability to combat lethal CCHFV infection in the STAT-1 −/− mouse model after vaccination (Fig. 5A,B) . Now that we have established that this new vector can provide protective benefit, our future studies will temporally examine the antibody and T cell repertoire after prime and boosting doses following ΔGrVSV-CCHFV-GPCΔ, but before CCHFV challenge, as these would be informative for the STAT-1 −/− mouse model.	./cache/cord-003667-u1xa44nw.txt	./txt/cord-003667-u1xa44nw.txt