id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-352744-dd2rbsla	Pagano, Maria Teresa	Vitamin D and Sex Differences in COVID-19	2020-09-30		.txt	text/plain	1507	68	35	In particular, it plays a key role in the control of the cytokine storm, i.e., the sudden acute increase in circulating levels of different pro-inflammatory cytokines, induced in several inflammatory conditions and also in COVID-19 (7) . ACE2 plays a protective role in acute respiratory distress syndrome and higher levels of ACE2 seem to be associated with better outcomes for lung diseases and, in particular, for COVID-19 (11) (12) (13) . To note, epidemiological data indicate that COVID-19 has a significantly higher lethality in men than in women (ratios up to 3:1), suggesting the presence of sex-dependent biological factors underlying these differences in disease outcome (16, 17) . Interestingly, sex differences have been observed in the immunomodulatory and anti-inflammatory effects of Vitamin D3 in some autoimmune diseases. In particular, it is tempting to hypothesize that the synergy between Vitamin D3 and estrogen could affect the sex differences in the outcome of patients with COVID-19.	./cache/cord-352744-dd2rbsla.txt	./txt/cord-352744-dd2rbsla.txt