id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-339166-f7tw90tm	Tecilazich, Francesco	Role of vitamin D in diabetic retinopathy: Pathophysiological and clinical aspects	2020-10-07		.txt	text/plain	6983	308	35	Since hypovitaminosis D is very frequent in patients with diabetes and vitamin D (VD) has vascular protective properties, several studies have addressed the association of VD deficiency with DR and its severity and progression, whereas the effects of VD supplementation on its natural history are largely unknown. Moreover, several studies have addressed, without reaching to date an univocal conclusion, the prevalence and role of hypovitaminosis D in diabetes, as well as the impact of VD supplementation on the natural history of diabetes, blood Fig. 1 Metabolic pathways involved in the synthesis of VD, main external sources of VD and the potential mechanisms underlying widespread hypovitaminosis D (defined according to Sempos et al., 2018 [2] glucose control, and prevalence and severity of its macro and microvascular complications [6, 12] . Noteworthy, a sub-analysis of the Field Study, a placebo-controlled trial on nearly 10,000 T2DM patients, showed that subjects with hypovitaminosis D had a higher cumulative incidence of microvascular events; in fact, a 50 nmol/L difference in VD levels was associated with a 18% (p = 0.007) increase in risk of microvascular complications [83] .	./cache/cord-339166-f7tw90tm.txt	./txt/cord-339166-f7tw90tm.txt