id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-284193-qslc2wry	Malek Mahdavi, Aida	A brief review of interplay between vitamin D and angiotensin‐converting enzyme 2: Implications for a potential treatment for COVID‐19	2020-06-25		.txt	text/plain	3226	208	44	It can induce ACE2/Ang‐(1‐7)/MasR axis activity and inhibits renin and the ACE/Ang II/AT1R axis, thereby increasing expression and concentration of ACE2, MasR and Ang‐(1‐7) and having a potential protective role against acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Angiotensin-converting enzyme 2 (ACE2), a part of the reninangiotensin system (RAS), serves as the major entry point into cells for some coronaviruses such as HCoV-NL63, SARS-CoV and SARS-CoV-2 that cause SARS and COVID-19, respectively. 71, 72 Although it is more likely that any protective effect of vitamin D against COVID-19 is related to suppression of cytokine response and reduced severity/risk for ARDS, there is also evidence from a meta-analysis that regular oral vitamin D2/D3 intake (in doses up to 2000 IU/day) is safe and protective against acute respiratory tract infection, especially in subjects with vitamin D deficiency.	./cache/cord-284193-qslc2wry.txt	./txt/cord-284193-qslc2wry.txt