id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004297-rm0zbgfm	Hemilä, Harri	Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis	2020-02-07		.txt	text/plain	5040	295	55	Because of the high dropout rate (42%), we did not include this trial in our calculations, but we overlay the findings in Fig. 4 iv intravenous, po per oral, RoM ratio of means [22] : e.g., for the Bjordahl trial [11] , RoM = 0.86, based on 28.8/33.6, and RoM = 0.86 indicates that ventilation time in the vitamin C group was 14% shorter than in the placebo group (RoM) [22] . In a meta-regression analysis, we found that the heterogeneity between the trials was explained by the length of mechanical ventilation in the untreated control group (Fig. 4) . Thus, the statistically significant benefit observed in each of these three trials might be explained by the long ventilation time in the control groups, indicating greater severity of illness in the patients, rather than by the addition of vitamin E to the intervention. Although our meta-regression analysis by the ventilation time in the control group explains the heterogeneity in the published trials, it seems evident that other variables influence the effects of vitamin C.	./cache/cord-004297-rm0zbgfm.txt	./txt/cord-004297-rm0zbgfm.txt