id sid tid token lemma pos cord-323404-3mw4q7m3 1 1 key key JJ cord-323404-3mw4q7m3 1 2 : : : cord-323404-3mw4q7m3 1 3 cord-323404 cord-323404 NNP cord-323404-3mw4q7m3 1 4 - - HYPH cord-323404-3mw4q7m3 1 5 3mw4q7m3 3mw4q7m3 CD cord-323404-3mw4q7m3 1 6 authors author NNS cord-323404-3mw4q7m3 1 7 : : : cord-323404-3mw4q7m3 1 8 Bomsel Bomsel NNP cord-323404-3mw4q7m3 1 9 , , , cord-323404-3mw4q7m3 1 10 Morgane Morgane NNP cord-323404-3mw4q7m3 1 11 ; ; : cord-323404-3mw4q7m3 1 12 Alfsen Alfsen NNP cord-323404-3mw4q7m3 1 13 , , , cord-323404-3mw4q7m3 1 14 Annette Annette NNP cord-323404-3mw4q7m3 1 15 title title NN cord-323404-3mw4q7m3 1 16 : : : cord-323404-3mw4q7m3 1 17 Entry entry NN cord-323404-3mw4q7m3 1 18 of of IN cord-323404-3mw4q7m3 1 19 viruses virus NNS cord-323404-3mw4q7m3 1 20 through through IN cord-323404-3mw4q7m3 1 21 the the DT cord-323404-3mw4q7m3 1 22 epithelial epithelial JJ cord-323404-3mw4q7m3 1 23 barrier barrier NN cord-323404-3mw4q7m3 1 24 : : : cord-323404-3mw4q7m3 1 25 pathogenic pathogenic JJ cord-323404-3mw4q7m3 1 26 trickery trickery NN cord-323404-3mw4q7m3 1 27 date date NN cord-323404-3mw4q7m3 1 28 : : : cord-323404-3mw4q7m3 2 1 2003 2003 CD cord-323404-3mw4q7m3 2 2 journal journal NNP cord-323404-3mw4q7m3 2 3 : : : cord-323404-3mw4q7m3 3 1 Nat Nat NNP cord-323404-3mw4q7m3 3 2 Rev Rev NNP cord-323404-3mw4q7m3 3 3 Mol Mol NNP cord-323404-3mw4q7m3 3 4 Cell Cell NNP cord-323404-3mw4q7m3 4 1 Biol Biol NNP cord-323404-3mw4q7m3 4 2 DOI DOI NNP cord-323404-3mw4q7m3 4 3 : : : cord-323404-3mw4q7m3 5 1 10.1038 10.1038 CD cord-323404-3mw4q7m3 5 2 / / SYM cord-323404-3mw4q7m3 5 3 nrm1005 nrm1005 NNP cord-323404-3mw4q7m3 5 4 sha sha NNP cord-323404-3mw4q7m3 5 5 : : : cord-323404-3mw4q7m3 5 6 76fc62189e39905c1139ab8a7de439a85ed8f9d7 76fc62189e39905c1139ab8a7de439a85ed8f9d7 CD cord-323404-3mw4q7m3 5 7 doc_id doc_id CD cord-323404-3mw4q7m3 5 8 : : : cord-323404-3mw4q7m3 5 9 323404 323404 CD cord-323404-3mw4q7m3 5 10 cord_uid cord_uid NN cord-323404-3mw4q7m3 5 11 : : : cord-323404-3mw4q7m3 6 1 3mw4q7m3 3mw4q7m3 CD cord-323404-3mw4q7m3 6 2 Mucosal Mucosal NNP cord-323404-3mw4q7m3 6 3 surfaces surface NNS cord-323404-3mw4q7m3 6 4 — — : cord-323404-3mw4q7m3 6 5 such such JJ cord-323404-3mw4q7m3 6 6 as as IN cord-323404-3mw4q7m3 6 7 the the DT cord-323404-3mw4q7m3 6 8 lining lining NN cord-323404-3mw4q7m3 6 9 of of IN cord-323404-3mw4q7m3 6 10 the the DT cord-323404-3mw4q7m3 6 11 gut gut NN cord-323404-3mw4q7m3 6 12 or or CC cord-323404-3mw4q7m3 6 13 the the DT cord-323404-3mw4q7m3 6 14 reproductive reproductive JJ cord-323404-3mw4q7m3 6 15 tract tract NN cord-323404-3mw4q7m3 6 16 — — : cord-323404-3mw4q7m3 6 17 are be VBP cord-323404-3mw4q7m3 6 18 the the DT cord-323404-3mw4q7m3 6 19 main main JJ cord-323404-3mw4q7m3 6 20 point point NN cord-323404-3mw4q7m3 6 21 of of IN cord-323404-3mw4q7m3 6 22 entry entry NN cord-323404-3mw4q7m3 6 23 for for IN cord-323404-3mw4q7m3 6 24 viruses virus NNS cord-323404-3mw4q7m3 6 25 into into IN cord-323404-3mw4q7m3 6 26 the the DT cord-323404-3mw4q7m3 6 27 body body NN cord-323404-3mw4q7m3 6 28 . . . cord-323404-3mw4q7m3 7 1 As as IN cord-323404-3mw4q7m3 7 2 such such JJ cord-323404-3mw4q7m3 7 3 , , , cord-323404-3mw4q7m3 7 4 almost almost RB cord-323404-3mw4q7m3 7 5 all all DT cord-323404-3mw4q7m3 7 6 viruses virus NNS cord-323404-3mw4q7m3 7 7 interact interact VBP cord-323404-3mw4q7m3 7 8 with with IN cord-323404-3mw4q7m3 7 9 epithelial epithelial JJ cord-323404-3mw4q7m3 7 10 cells cell NNS cord-323404-3mw4q7m3 7 11 , , , cord-323404-3mw4q7m3 7 12 and and CC cord-323404-3mw4q7m3 7 13 make make VB cord-323404-3mw4q7m3 7 14 use use NN cord-323404-3mw4q7m3 7 15 of of IN cord-323404-3mw4q7m3 7 16 the the DT cord-323404-3mw4q7m3 7 17 normal normal JJ cord-323404-3mw4q7m3 7 18 epithelial epithelial JJ cord-323404-3mw4q7m3 7 19 signalling signalling NN cord-323404-3mw4q7m3 7 20 and and CC cord-323404-3mw4q7m3 7 21 trafficking traffic VBG cord-323404-3mw4q7m3 7 22 pathways pathway NNS cord-323404-3mw4q7m3 7 23 of of IN cord-323404-3mw4q7m3 7 24 the the DT cord-323404-3mw4q7m3 7 25 host host NN cord-323404-3mw4q7m3 7 26 cell cell NN cord-323404-3mw4q7m3 7 27 . . . cord-323404-3mw4q7m3 8 1 In in IN cord-323404-3mw4q7m3 8 2 addition addition NN cord-323404-3mw4q7m3 8 3 to to IN cord-323404-3mw4q7m3 8 4 protein protein NN cord-323404-3mw4q7m3 8 5 receptors receptor NNS cord-323404-3mw4q7m3 8 6 , , , cord-323404-3mw4q7m3 8 7 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 8 8 chains chain NNS cord-323404-3mw4q7m3 8 9 of of IN cord-323404-3mw4q7m3 8 10 proteoglycans proteoglycan NNS cord-323404-3mw4q7m3 8 11 and and CC cord-323404-3mw4q7m3 8 12 epithelial epithelial JJ cord-323404-3mw4q7m3 8 13 - - HYPH cord-323404-3mw4q7m3 8 14 membrane membrane NN cord-323404-3mw4q7m3 8 15 glycosphingolipids glycosphingolipid NNS cord-323404-3mw4q7m3 8 16 have have VBP cord-323404-3mw4q7m3 8 17 emerged emerge VBN cord-323404-3mw4q7m3 8 18 as as IN cord-323404-3mw4q7m3 8 19 a a DT cord-323404-3mw4q7m3 8 20 new new JJ cord-323404-3mw4q7m3 8 21 class class NN cord-323404-3mw4q7m3 8 22 of of IN cord-323404-3mw4q7m3 8 23 receptors receptor NNS cord-323404-3mw4q7m3 8 24 for for IN cord-323404-3mw4q7m3 8 25 viral viral JJ cord-323404-3mw4q7m3 8 26 attachment attachment NN cord-323404-3mw4q7m3 8 27 to to IN cord-323404-3mw4q7m3 8 28 the the DT cord-323404-3mw4q7m3 8 29 host host NN cord-323404-3mw4q7m3 8 30 cell cell NN cord-323404-3mw4q7m3 8 31 . . . cord-323404-3mw4q7m3 9 1 Viruses virus NNS cord-323404-3mw4q7m3 9 2 enter enter VBP cord-323404-3mw4q7m3 9 3 the the DT cord-323404-3mw4q7m3 9 4 body body NN cord-323404-3mw4q7m3 9 5 through through IN cord-323404-3mw4q7m3 9 6 two two CD cord-323404-3mw4q7m3 9 7 main main JJ cord-323404-3mw4q7m3 9 8 surfaces surface NNS cord-323404-3mw4q7m3 9 9 -the -the ADD cord-323404-3mw4q7m3 9 10 skin skin NN cord-323404-3mw4q7m3 9 11 and and CC cord-323404-3mw4q7m3 9 12 the the DT cord-323404-3mw4q7m3 9 13 mucosal mucosal JJ cord-323404-3mw4q7m3 9 14 epithelia epithelium NNS cord-323404-3mw4q7m3 9 15 . . . cord-323404-3mw4q7m3 10 1 These these DT cord-323404-3mw4q7m3 10 2 surfaces surface NNS cord-323404-3mw4q7m3 10 3 are be VBP cord-323404-3mw4q7m3 10 4 covered cover VBN cord-323404-3mw4q7m3 10 5 by by IN cord-323404-3mw4q7m3 10 6 epithelial epithelial JJ cord-323404-3mw4q7m3 10 7 cells cell NNS cord-323404-3mw4q7m3 10 8 that that WDT cord-323404-3mw4q7m3 10 9 are be VBP cord-323404-3mw4q7m3 10 10 organized organize VBN cord-323404-3mw4q7m3 10 11 into into IN cord-323404-3mw4q7m3 10 12 complex complex JJ cord-323404-3mw4q7m3 10 13 structures structure NNS cord-323404-3mw4q7m3 10 14 ( ( -LRB- cord-323404-3mw4q7m3 10 15 BOX BOX NNP cord-323404-3mw4q7m3 10 16 1 1 CD cord-323404-3mw4q7m3 10 17 ) ) -RRB- cord-323404-3mw4q7m3 10 18 , , , cord-323404-3mw4q7m3 10 19 and and CC cord-323404-3mw4q7m3 10 20 this this DT cord-323404-3mw4q7m3 10 21 epithelial epithelial JJ cord-323404-3mw4q7m3 10 22 organization organization NN cord-323404-3mw4q7m3 10 23 often often RB cord-323404-3mw4q7m3 10 24 dictates dictate VBZ cord-323404-3mw4q7m3 10 25 the the DT cord-323404-3mw4q7m3 10 26 mechanisms mechanism NNS cord-323404-3mw4q7m3 10 27 of of IN cord-323404-3mw4q7m3 10 28 viral viral JJ cord-323404-3mw4q7m3 10 29 entry entry NN cord-323404-3mw4q7m3 10 30 and and CC cord-323404-3mw4q7m3 10 31 translocation translocation NN cord-323404-3mw4q7m3 10 32 . . . cord-323404-3mw4q7m3 11 1 In in IN cord-323404-3mw4q7m3 11 2 this this DT cord-323404-3mw4q7m3 11 3 review review NN cord-323404-3mw4q7m3 11 4 , , , cord-323404-3mw4q7m3 11 5 we -PRON- PRP cord-323404-3mw4q7m3 11 6 explore explore VBP cord-323404-3mw4q7m3 11 7 the the DT cord-323404-3mw4q7m3 11 8 strategies strategy NNS cord-323404-3mw4q7m3 11 9 that that WDT cord-323404-3mw4q7m3 11 10 viruses virus NNS cord-323404-3mw4q7m3 11 11 have have VBP cord-323404-3mw4q7m3 11 12 evolved evolve VBN cord-323404-3mw4q7m3 11 13 to to TO cord-323404-3mw4q7m3 11 14 translocate translocate VB cord-323404-3mw4q7m3 11 15 across across IN cord-323404-3mw4q7m3 11 16 the the DT cord-323404-3mw4q7m3 11 17 epithelial epithelial JJ cord-323404-3mw4q7m3 11 18 barrier barrier NN cord-323404-3mw4q7m3 11 19 and and CC cord-323404-3mw4q7m3 11 20 to to TO cord-323404-3mw4q7m3 11 21 act act VB cord-323404-3mw4q7m3 11 22 as as IN cord-323404-3mw4q7m3 11 23 pathogens pathogen NNS cord-323404-3mw4q7m3 11 24 , , , cord-323404-3mw4q7m3 11 25 according accord VBG cord-323404-3mw4q7m3 11 26 to to IN cord-323404-3mw4q7m3 11 27 the the DT cord-323404-3mw4q7m3 11 28 target target NN cord-323404-3mw4q7m3 11 29 - - HYPH cord-323404-3mw4q7m3 11 30 cell cell NN cord-323404-3mw4q7m3 11 31 structure structure NN cord-323404-3mw4q7m3 11 32 and and CC cord-323404-3mw4q7m3 11 33 the the DT cord-323404-3mw4q7m3 11 34 nature nature NN cord-323404-3mw4q7m3 11 35 of of IN cord-323404-3mw4q7m3 11 36 the the DT cord-323404-3mw4q7m3 11 37 virus virus NN cord-323404-3mw4q7m3 11 38 . . . cord-323404-3mw4q7m3 12 1 To to TO cord-323404-3mw4q7m3 12 2 understand understand VB cord-323404-3mw4q7m3 12 3 these these DT cord-323404-3mw4q7m3 12 4 mechanisms mechanism NNS cord-323404-3mw4q7m3 12 5 , , , cord-323404-3mw4q7m3 12 6 we -PRON- PRP cord-323404-3mw4q7m3 12 7 first first RB cord-323404-3mw4q7m3 12 8 map map VBP cord-323404-3mw4q7m3 12 9 the the DT cord-323404-3mw4q7m3 12 10 pathways pathway NNS cord-323404-3mw4q7m3 12 11 of of IN cord-323404-3mw4q7m3 12 12 viral viral JJ cord-323404-3mw4q7m3 12 13 entry entry NN cord-323404-3mw4q7m3 12 14 . . . cord-323404-3mw4q7m3 13 1 Then then RB cord-323404-3mw4q7m3 13 2 we -PRON- PRP cord-323404-3mw4q7m3 13 3 describe describe VBP cord-323404-3mw4q7m3 13 4 , , , cord-323404-3mw4q7m3 13 5 at at IN cord-323404-3mw4q7m3 13 6 the the DT cord-323404-3mw4q7m3 13 7 molecular molecular JJ cord-323404-3mw4q7m3 13 8 level level NN cord-323404-3mw4q7m3 13 9 , , , cord-323404-3mw4q7m3 13 10 the the DT cord-323404-3mw4q7m3 13 11 cell cell NN cord-323404-3mw4q7m3 13 12 receptors receptor NNS cord-323404-3mw4q7m3 13 13 that that WDT cord-323404-3mw4q7m3 13 14 allow allow VBP cord-323404-3mw4q7m3 13 15 viral viral JJ cord-323404-3mw4q7m3 13 16 attachment attachment NN cord-323404-3mw4q7m3 13 17 and and CC cord-323404-3mw4q7m3 13 18 entry entry NN cord-323404-3mw4q7m3 13 19 into into IN cord-323404-3mw4q7m3 13 20 the the DT cord-323404-3mw4q7m3 13 21 cell cell NN cord-323404-3mw4q7m3 13 22 , , , cord-323404-3mw4q7m3 13 23 as as RB cord-323404-3mw4q7m3 13 24 well well RB cord-323404-3mw4q7m3 13 25 as as IN cord-323404-3mw4q7m3 13 26 the the DT cord-323404-3mw4q7m3 13 27 viral viral JJ cord-323404-3mw4q7m3 13 28 proteins protein NNS cord-323404-3mw4q7m3 13 29 that that WDT cord-323404-3mw4q7m3 13 30 interact interact VBP cord-323404-3mw4q7m3 13 31 withand withand NN cord-323404-3mw4q7m3 13 32 subvert subvert VB cord-323404-3mw4q7m3 13 33 -these -these JJ cord-323404-3mw4q7m3 13 34 receptors receptor NNS cord-323404-3mw4q7m3 13 35 , , , cord-323404-3mw4q7m3 13 36 which which WDT cord-323404-3mw4q7m3 13 37 allows allow VBZ cord-323404-3mw4q7m3 13 38 the the DT cord-323404-3mw4q7m3 13 39 virus virus NN cord-323404-3mw4q7m3 13 40 to to TO cord-323404-3mw4q7m3 13 41 cross cross VB cord-323404-3mw4q7m3 13 42 the the DT cord-323404-3mw4q7m3 13 43 cell cell NN cord-323404-3mw4q7m3 13 44 membrane membrane NN cord-323404-3mw4q7m3 13 45 . . . cord-323404-3mw4q7m3 14 1 Our -PRON- PRP$ cord-323404-3mw4q7m3 14 2 understanding understanding NN cord-323404-3mw4q7m3 14 3 of of IN cord-323404-3mw4q7m3 14 4 host host NN cord-323404-3mw4q7m3 14 5 - - HYPH cord-323404-3mw4q7m3 14 6 virus virus NN cord-323404-3mw4q7m3 14 7 interactions interaction NNS cord-323404-3mw4q7m3 14 8 at at IN cord-323404-3mw4q7m3 14 9 the the DT cord-323404-3mw4q7m3 14 10 molecular molecular JJ cord-323404-3mw4q7m3 14 11 level level NN cord-323404-3mw4q7m3 14 12 has have VBZ cord-323404-3mw4q7m3 14 13 allowed allow VBN cord-323404-3mw4q7m3 14 14 the the DT cord-323404-3mw4q7m3 14 15 characterization characterization NN cord-323404-3mw4q7m3 14 16 of of IN cord-323404-3mw4q7m3 14 17 many many JJ cord-323404-3mw4q7m3 14 18 viral viral JJ cord-323404-3mw4q7m3 14 19 receptors receptor NNS cord-323404-3mw4q7m3 14 20 at at IN cord-323404-3mw4q7m3 14 21 the the DT cord-323404-3mw4q7m3 14 22 epithelial epithelial JJ cord-323404-3mw4q7m3 14 23 surface surface NN cord-323404-3mw4q7m3 14 24 . . . cord-323404-3mw4q7m3 15 1 The the DT cord-323404-3mw4q7m3 15 2 accepted accepted JJ cord-323404-3mw4q7m3 15 3 model model NN cord-323404-3mw4q7m3 15 4 of of IN cord-323404-3mw4q7m3 15 5 viral viral JJ cord-323404-3mw4q7m3 15 6 entry entry NN cord-323404-3mw4q7m3 15 7 that that WDT cord-323404-3mw4q7m3 15 8 is be VBZ cord-323404-3mw4q7m3 15 9 achieved achieve VBN cord-323404-3mw4q7m3 15 10 using use VBG cord-323404-3mw4q7m3 15 11 a a DT cord-323404-3mw4q7m3 15 12 unique unique JJ cord-323404-3mw4q7m3 15 13 viral viral JJ cord-323404-3mw4q7m3 15 14 receptor receptor NN cord-323404-3mw4q7m3 15 15 has have VBZ cord-323404-3mw4q7m3 15 16 been be VBN cord-323404-3mw4q7m3 15 17 challenged challenge VBN cord-323404-3mw4q7m3 15 18 . . . cord-323404-3mw4q7m3 16 1 Instead instead RB cord-323404-3mw4q7m3 16 2 , , , cord-323404-3mw4q7m3 16 3 viruses virus NNS cord-323404-3mw4q7m3 16 4 are be VBP cord-323404-3mw4q7m3 16 5 now now RB cord-323404-3mw4q7m3 16 6 thought think VBN cord-323404-3mw4q7m3 16 7 to to TO cord-323404-3mw4q7m3 16 8 use use VB cord-323404-3mw4q7m3 16 9 host host NN cord-323404-3mw4q7m3 16 10 - - HYPH cord-323404-3mw4q7m3 16 11 cell cell NN cord-323404-3mw4q7m3 16 12 moleculeswhich moleculeswhich NNS cord-323404-3mw4q7m3 16 13 are be VBP cord-323404-3mw4q7m3 16 14 referred refer VBN cord-323404-3mw4q7m3 16 15 to to IN cord-323404-3mw4q7m3 16 16 as as IN cord-323404-3mw4q7m3 16 17 attachment attachment NN cord-323404-3mw4q7m3 16 18 receptors receptor NNS cord-323404-3mw4q7m3 16 19 or or CC cord-323404-3mw4q7m3 16 20 ' ' `` cord-323404-3mw4q7m3 16 21 coreceptors coreceptor NNS cord-323404-3mw4q7m3 16 22 ' ' '' cord-323404-3mw4q7m3 16 23 -in -in IN cord-323404-3mw4q7m3 16 24 addition addition NN cord-323404-3mw4q7m3 16 25 to to IN cord-323404-3mw4q7m3 16 26 the the DT cord-323404-3mw4q7m3 16 27 protein protein NN cord-323404-3mw4q7m3 16 28 receptor receptor NN cord-323404-3mw4q7m3 16 29 , , , cord-323404-3mw4q7m3 16 30 which which WDT cord-323404-3mw4q7m3 16 31 is be VBZ cord-323404-3mw4q7m3 16 32 often often RB cord-323404-3mw4q7m3 16 33 renamed rename VBN cord-323404-3mw4q7m3 16 34 the the DT cord-323404-3mw4q7m3 16 35 ' ' `` cord-323404-3mw4q7m3 16 36 principal principal NN cord-323404-3mw4q7m3 16 37 ' ' '' cord-323404-3mw4q7m3 16 38 receptor receptor NN cord-323404-3mw4q7m3 16 39 . . . cord-323404-3mw4q7m3 17 1 The the DT cord-323404-3mw4q7m3 17 2 dynamics dynamic NNS cord-323404-3mw4q7m3 17 3 of of IN cord-323404-3mw4q7m3 17 4 these these DT cord-323404-3mw4q7m3 17 5 receptors receptor NNS cord-323404-3mw4q7m3 17 6 in in IN cord-323404-3mw4q7m3 17 7 the the DT cord-323404-3mw4q7m3 17 8 membrane membrane NN cord-323404-3mw4q7m3 17 9 is be VBZ cord-323404-3mw4q7m3 17 10 crucial crucial JJ cord-323404-3mw4q7m3 17 11 because because IN cord-323404-3mw4q7m3 17 12 , , , cord-323404-3mw4q7m3 17 13 on on IN cord-323404-3mw4q7m3 17 14 binding binding NN cord-323404-3mw4q7m3 17 15 of of IN cord-323404-3mw4q7m3 17 16 the the DT cord-323404-3mw4q7m3 17 17 virus virus NN cord-323404-3mw4q7m3 17 18 , , , cord-323404-3mw4q7m3 17 19 receptors receptor NNS cord-323404-3mw4q7m3 17 20 can can MD cord-323404-3mw4q7m3 17 21 be be VB cord-323404-3mw4q7m3 17 22 recruited recruit VBN cord-323404-3mw4q7m3 17 23 to to IN cord-323404-3mw4q7m3 17 24 or or CC cord-323404-3mw4q7m3 17 25 excluded exclude VBN cord-323404-3mw4q7m3 17 26 from from IN cord-323404-3mw4q7m3 17 27 transiently transiently RB cord-323404-3mw4q7m3 17 28 organized organize VBN cord-323404-3mw4q7m3 17 29 glycosphingolipidrich glycosphingolipidrich JJ cord-323404-3mw4q7m3 17 30 membrane membrane NN cord-323404-3mw4q7m3 17 31 microdomains microdomain NNS cord-323404-3mw4q7m3 17 32 , , , cord-323404-3mw4q7m3 17 33 which which WDT cord-323404-3mw4q7m3 17 34 are be VBP cord-323404-3mw4q7m3 17 35 known know VBN cord-323404-3mw4q7m3 17 36 as as IN cord-323404-3mw4q7m3 17 37 lipid lipid NN cord-323404-3mw4q7m3 17 38 RAFTS raft NNS cord-323404-3mw4q7m3 17 39 . . . cord-323404-3mw4q7m3 18 1 An an DT cord-323404-3mw4q7m3 18 2 important important JJ cord-323404-3mw4q7m3 18 3 class class NN cord-323404-3mw4q7m3 18 4 of of IN cord-323404-3mw4q7m3 18 5 attachment attachment NN cord-323404-3mw4q7m3 18 6 receptors receptor NNS cord-323404-3mw4q7m3 18 7 has have VBZ cord-323404-3mw4q7m3 18 8 emerged emerge VBN cord-323404-3mw4q7m3 18 9 recently recently RB cord-323404-3mw4q7m3 18 10 -namely -namely RB cord-323404-3mw4q7m3 18 11 the the DT cord-323404-3mw4q7m3 18 12 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 18 13 chain chain NN cord-323404-3mw4q7m3 18 14 of of IN cord-323404-3mw4q7m3 18 15 PROTEOGLYCANS proteoglycan NNS cord-323404-3mw4q7m3 18 16 and and CC cord-323404-3mw4q7m3 18 17 epithelial epithelial NN cord-323404-3mw4q7m3 18 18 - - HYPH cord-323404-3mw4q7m3 18 19 membrane membrane NN cord-323404-3mw4q7m3 18 20 GLYCOSPHINGOLIPIDS GLYCOSPHINGOLIPIDS NNP cord-323404-3mw4q7m3 18 21 ( ( -LRB- cord-323404-3mw4q7m3 18 22 FIG FIG NNP cord-323404-3mw4q7m3 18 23 . . . cord-323404-3mw4q7m3 18 24 1 1 CD cord-323404-3mw4q7m3 18 25 ) ) -RRB- cord-323404-3mw4q7m3 18 26 . . . cord-323404-3mw4q7m3 19 1 There there EX cord-323404-3mw4q7m3 19 2 is be VBZ cord-323404-3mw4q7m3 19 3 growing grow VBG cord-323404-3mw4q7m3 19 4 recognition recognition NN cord-323404-3mw4q7m3 19 5 of of IN cord-323404-3mw4q7m3 19 6 the the DT cord-323404-3mw4q7m3 19 7 functional functional JJ cord-323404-3mw4q7m3 19 8 importance importance NN cord-323404-3mw4q7m3 19 9 of of IN cord-323404-3mw4q7m3 19 10 these these DT cord-323404-3mw4q7m3 19 11 biomolecules biomolecule NNS cord-323404-3mw4q7m3 19 12 , , , cord-323404-3mw4q7m3 19 13 as as IN cord-323404-3mw4q7m3 19 14 shown show VBN cord-323404-3mw4q7m3 19 15 by by IN cord-323404-3mw4q7m3 19 16 the the DT cord-323404-3mw4q7m3 19 17 emergence emergence NN cord-323404-3mw4q7m3 19 18 of of IN cord-323404-3mw4q7m3 19 19 the the DT cord-323404-3mw4q7m3 19 20 field field NN cord-323404-3mw4q7m3 19 21 of of IN cord-323404-3mw4q7m3 19 22 ' ' `` cord-323404-3mw4q7m3 19 23 glycomics glycomic NNS cord-323404-3mw4q7m3 19 24 ' ' '' cord-323404-3mw4q7m3 19 25 , , , cord-323404-3mw4q7m3 19 26 or or CC cord-323404-3mw4q7m3 19 27 ' ' `` cord-323404-3mw4q7m3 19 28 the the DT cord-323404-3mw4q7m3 19 29 sugar sugar NN cord-323404-3mw4q7m3 19 30 code code NN cord-323404-3mw4q7m3 19 31 ' ' '' cord-323404-3mw4q7m3 19 32 1 1 CD cord-323404-3mw4q7m3 19 33 . . . cord-323404-3mw4q7m3 20 1 Indeed indeed RB cord-323404-3mw4q7m3 20 2 , , , cord-323404-3mw4q7m3 20 3 oligosaccharides oligosaccharide NNS cord-323404-3mw4q7m3 20 4 transfer transfer VBP cord-323404-3mw4q7m3 20 5 information information NN cord-323404-3mw4q7m3 20 6 to to IN cord-323404-3mw4q7m3 20 7 complementary complementary JJ cord-323404-3mw4q7m3 20 8 effector effector NN cord-323404-3mw4q7m3 20 9 molecules molecule NNS cord-323404-3mw4q7m3 20 10 , , , cord-323404-3mw4q7m3 20 11 and and CC cord-323404-3mw4q7m3 20 12 the the DT cord-323404-3mw4q7m3 20 13 virus virus NN cord-323404-3mw4q7m3 20 14 acts act VBZ cord-323404-3mw4q7m3 20 15 as as IN cord-323404-3mw4q7m3 20 16 a a DT cord-323404-3mw4q7m3 20 17 LECTIN lectin NN cord-323404-3mw4q7m3 20 18 by by IN cord-323404-3mw4q7m3 20 19 binding bind VBG cord-323404-3mw4q7m3 20 20 the the DT cord-323404-3mw4q7m3 20 21 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 20 22 as as IN cord-323404-3mw4q7m3 20 23 an an DT cord-323404-3mw4q7m3 20 24 attachment attachment NN cord-323404-3mw4q7m3 20 25 receptor receptor NN cord-323404-3mw4q7m3 20 26 . . . cord-323404-3mw4q7m3 21 1 Owing owe VBG cord-323404-3mw4q7m3 21 2 to to IN cord-323404-3mw4q7m3 21 3 the the DT cord-323404-3mw4q7m3 21 4 nature nature NN cord-323404-3mw4q7m3 21 5 of of IN cord-323404-3mw4q7m3 21 6 the the DT cord-323404-3mw4q7m3 21 7 lectin lectin NN cord-323404-3mw4q7m3 21 8 - - HYPH cord-323404-3mw4q7m3 21 9 sugar sugar NN cord-323404-3mw4q7m3 21 10 interaction interaction NN cord-323404-3mw4q7m3 21 11 ( ( -LRB- cord-323404-3mw4q7m3 21 12 namely namely RB cord-323404-3mw4q7m3 21 13 charge charge NN cord-323404-3mw4q7m3 21 14 - - HYPH cord-323404-3mw4q7m3 21 15 transfer transfer NN cord-323404-3mw4q7m3 21 16 processes process NNS cord-323404-3mw4q7m3 21 17 that that WDT cord-323404-3mw4q7m3 21 18 are be VBP cord-323404-3mw4q7m3 21 19 facilitated facilitate VBN cord-323404-3mw4q7m3 21 20 by by IN cord-323404-3mw4q7m3 21 21 networks network NNS cord-323404-3mw4q7m3 21 22 of of IN cord-323404-3mw4q7m3 21 23 hydrogen hydrogen NN cord-323404-3mw4q7m3 21 24 - - HYPH cord-323404-3mw4q7m3 21 25 bond bond NN cord-323404-3mw4q7m3 21 26 formation formation NN cord-323404-3mw4q7m3 21 27 ) ) -RRB- cord-323404-3mw4q7m3 21 28 , , , cord-323404-3mw4q7m3 21 29 environmental environmental JJ cord-323404-3mw4q7m3 21 30 factors factor NNS cord-323404-3mw4q7m3 21 31 are be VBP cord-323404-3mw4q7m3 21 32 important important JJ cord-323404-3mw4q7m3 21 33 . . . cord-323404-3mw4q7m3 22 1 These these DT cord-323404-3mw4q7m3 22 2 factors factor NNS cord-323404-3mw4q7m3 22 3 relate relate VBP cord-323404-3mw4q7m3 22 4 to to IN cord-323404-3mw4q7m3 22 5 the the DT cord-323404-3mw4q7m3 22 6 characteristics characteristic NNS cord-323404-3mw4q7m3 22 7 of of IN cord-323404-3mw4q7m3 22 8 the the DT cord-323404-3mw4q7m3 22 9 mucosal mucosal NN cord-323404-3mw4q7m3 22 10 surface surface NN cord-323404-3mw4q7m3 22 11 , , , cord-323404-3mw4q7m3 22 12 which which WDT cord-323404-3mw4q7m3 22 13 has have VBZ cord-323404-3mw4q7m3 22 14 numerous numerous JJ cord-323404-3mw4q7m3 22 15 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 22 16 groups group NNS cord-323404-3mw4q7m3 22 17 protruding protrude VBG cord-323404-3mw4q7m3 22 18 into into IN cord-323404-3mw4q7m3 22 19 the the DT cord-323404-3mw4q7m3 22 20 aqueous aqueous JJ cord-323404-3mw4q7m3 22 21 environment environment NN cord-323404-3mw4q7m3 22 22 and and CC cord-323404-3mw4q7m3 22 23 a a DT cord-323404-3mw4q7m3 22 24 high high JJ cord-323404-3mw4q7m3 22 25 ionic ionic JJ cord-323404-3mw4q7m3 22 26 strength strength NN cord-323404-3mw4q7m3 22 27 . . . cord-323404-3mw4q7m3 23 1 This this DT cord-323404-3mw4q7m3 23 2 high high JJ cord-323404-3mw4q7m3 23 3 ionic ionic JJ cord-323404-3mw4q7m3 23 4 strength strength NN cord-323404-3mw4q7m3 23 5 is be VBZ cord-323404-3mw4q7m3 23 6 due due JJ cord-323404-3mw4q7m3 23 7 to to IN cord-323404-3mw4q7m3 23 8 the the DT cord-323404-3mw4q7m3 23 9 charged charge VBN cord-323404-3mw4q7m3 23 10 surface surface NN cord-323404-3mw4q7m3 23 11 lipids lipid NNS cord-323404-3mw4q7m3 23 12 and and CC cord-323404-3mw4q7m3 23 13 their -PRON- PRP$ cord-323404-3mw4q7m3 23 14 counterions counterion NNS cord-323404-3mw4q7m3 23 15 . . . cord-323404-3mw4q7m3 24 1 On on IN cord-323404-3mw4q7m3 24 2 the the DT cord-323404-3mw4q7m3 24 3 viral viral JJ cord-323404-3mw4q7m3 24 4 oligomeric oligomeric JJ cord-323404-3mw4q7m3 24 5 peptide peptide NN cord-323404-3mw4q7m3 24 6 , , , cord-323404-3mw4q7m3 24 7 the the DT cord-323404-3mw4q7m3 24 8 lectin lectin NN cord-323404-3mw4q7m3 24 9 site site NN cord-323404-3mw4q7m3 24 10 is be VBZ cord-323404-3mw4q7m3 24 11 characterized characterize VBN cord-323404-3mw4q7m3 24 12 by by IN cord-323404-3mw4q7m3 24 13 the the DT cord-323404-3mw4q7m3 24 14 charged charge VBN cord-323404-3mw4q7m3 24 15 amino amino NN cord-323404-3mw4q7m3 24 16 acids acid NNS cord-323404-3mw4q7m3 24 17 and and CC cord-323404-3mw4q7m3 24 18 the the DT cord-323404-3mw4q7m3 24 19 aromatic aromatic JJ cord-323404-3mw4q7m3 24 20 tryptophan tryptophan NN cord-323404-3mw4q7m3 24 21 that that WDT cord-323404-3mw4q7m3 24 22 surrounds surround VBZ cord-323404-3mw4q7m3 24 23 the the DT cord-323404-3mw4q7m3 24 24 galactose galactose NN cord-323404-3mw4q7m3 24 25 ring ring NN cord-323404-3mw4q7m3 24 26 . . . cord-323404-3mw4q7m3 25 1 Viruses virus NNS cord-323404-3mw4q7m3 25 2 have have VBP cord-323404-3mw4q7m3 25 3 evolved evolve VBN cord-323404-3mw4q7m3 25 4 several several JJ cord-323404-3mw4q7m3 25 5 pathways pathway NNS cord-323404-3mw4q7m3 25 6 to to TO cord-323404-3mw4q7m3 25 7 initiate initiate VB cord-323404-3mw4q7m3 25 8 entry entry NN cord-323404-3mw4q7m3 25 9 through through IN cord-323404-3mw4q7m3 25 10 epithelial epithelial JJ cord-323404-3mw4q7m3 25 11 barriers barrier NNS cord-323404-3mw4q7m3 25 12 . . . cord-323404-3mw4q7m3 26 1 Viruses virus NNS cord-323404-3mw4q7m3 26 2 can can MD cord-323404-3mw4q7m3 26 3 enter enter VB cord-323404-3mw4q7m3 26 4 and and CC cord-323404-3mw4q7m3 26 5 infect infect VB cord-323404-3mw4q7m3 26 6 epithelial epithelial JJ cord-323404-3mw4q7m3 26 7 cells cell NNS cord-323404-3mw4q7m3 26 8 by by IN cord-323404-3mw4q7m3 26 9 accessing access VBG cord-323404-3mw4q7m3 26 10 the the DT cord-323404-3mw4q7m3 26 11 cell cell NN cord-323404-3mw4q7m3 26 12 cytosol cytosol NN cord-323404-3mw4q7m3 26 13 using use VBG cord-323404-3mw4q7m3 26 14 one one CD cord-323404-3mw4q7m3 26 15 of of IN cord-323404-3mw4q7m3 26 16 two two CD cord-323404-3mw4q7m3 26 17 mechanisms mechanism NNS cord-323404-3mw4q7m3 26 18 -direct -direct : cord-323404-3mw4q7m3 26 19 entry entry NN cord-323404-3mw4q7m3 26 20 at at IN cord-323404-3mw4q7m3 26 21 the the DT cord-323404-3mw4q7m3 26 22 epithelial epithelial JJ cord-323404-3mw4q7m3 26 23 plasma plasma NN cord-323404-3mw4q7m3 26 24 membrane membrane NN cord-323404-3mw4q7m3 26 25 , , , cord-323404-3mw4q7m3 26 26 or or CC cord-323404-3mw4q7m3 26 27 entry entry NN cord-323404-3mw4q7m3 26 28 through through IN cord-323404-3mw4q7m3 26 29 the the DT cord-323404-3mw4q7m3 26 30 epithelial epithelial JJ cord-323404-3mw4q7m3 26 31 endocytic endocytic JJ cord-323404-3mw4q7m3 26 32 pathway pathway NN cord-323404-3mw4q7m3 26 33 2 2 CD cord-323404-3mw4q7m3 26 34 . . . cord-323404-3mw4q7m3 27 1 By by IN cord-323404-3mw4q7m3 27 2 contrast contrast NN cord-323404-3mw4q7m3 27 3 , , , cord-323404-3mw4q7m3 27 4 some some DT cord-323404-3mw4q7m3 27 5 viruses virus NNS cord-323404-3mw4q7m3 27 6 do do VBP cord-323404-3mw4q7m3 27 7 not not RB cord-323404-3mw4q7m3 27 8 need need VB cord-323404-3mw4q7m3 27 9 to to TO cord-323404-3mw4q7m3 27 10 infect infect VB cord-323404-3mw4q7m3 27 11 epithelial epithelial JJ cord-323404-3mw4q7m3 27 12 cells cell NNS cord-323404-3mw4q7m3 27 13 to to TO cord-323404-3mw4q7m3 27 14 spread spread VB cord-323404-3mw4q7m3 27 15 -they -they WP cord-323404-3mw4q7m3 27 16 are be VBP cord-323404-3mw4q7m3 27 17 internalized internalize VBN cord-323404-3mw4q7m3 27 18 ENTRY entry NN cord-323404-3mw4q7m3 27 19 OF of IN cord-323404-3mw4q7m3 27 20 VIRUSES virus NNS cord-323404-3mw4q7m3 27 21 THROUGH through IN cord-323404-3mw4q7m3 27 22 THE the DT cord-323404-3mw4q7m3 27 23 EPITHELIAL EPITHELIAL NNP cord-323404-3mw4q7m3 27 24 BARRIER barrier NN cord-323404-3mw4q7m3 27 25 : : : cord-323404-3mw4q7m3 28 1 PATHOGENIC pathogenic JJ cord-323404-3mw4q7m3 28 2 TRICKERY trickery NN cord-323404-3mw4q7m3 29 1 Mucosal Mucosal NNP cord-323404-3mw4q7m3 29 2 surfaces surface NNS cord-323404-3mw4q7m3 29 3 -such -such : cord-323404-3mw4q7m3 29 4 as as IN cord-323404-3mw4q7m3 29 5 the the DT cord-323404-3mw4q7m3 29 6 lining lining NN cord-323404-3mw4q7m3 29 7 of of IN cord-323404-3mw4q7m3 29 8 the the DT cord-323404-3mw4q7m3 29 9 gut gut NN cord-323404-3mw4q7m3 29 10 or or CC cord-323404-3mw4q7m3 29 11 the the DT cord-323404-3mw4q7m3 29 12 reproductive reproductive JJ cord-323404-3mw4q7m3 29 13 tract tract NN cord-323404-3mw4q7m3 29 14 -are -are : cord-323404-3mw4q7m3 29 15 the the DT cord-323404-3mw4q7m3 29 16 main main JJ cord-323404-3mw4q7m3 29 17 point point NN cord-323404-3mw4q7m3 29 18 of of IN cord-323404-3mw4q7m3 29 19 entry entry NN cord-323404-3mw4q7m3 29 20 for for IN cord-323404-3mw4q7m3 29 21 viruses virus NNS cord-323404-3mw4q7m3 29 22 into into IN cord-323404-3mw4q7m3 29 23 the the DT cord-323404-3mw4q7m3 29 24 body body NN cord-323404-3mw4q7m3 29 25 . . . cord-323404-3mw4q7m3 30 1 As as IN cord-323404-3mw4q7m3 30 2 such such JJ cord-323404-3mw4q7m3 30 3 , , , cord-323404-3mw4q7m3 30 4 almost almost RB cord-323404-3mw4q7m3 30 5 all all DT cord-323404-3mw4q7m3 30 6 viruses virus NNS cord-323404-3mw4q7m3 30 7 interact interact VBP cord-323404-3mw4q7m3 30 8 with with IN cord-323404-3mw4q7m3 30 9 epithelial epithelial JJ cord-323404-3mw4q7m3 30 10 cells cell NNS cord-323404-3mw4q7m3 30 11 , , , cord-323404-3mw4q7m3 30 12 and and CC cord-323404-3mw4q7m3 30 13 make make VB cord-323404-3mw4q7m3 30 14 use use NN cord-323404-3mw4q7m3 30 15 of of IN cord-323404-3mw4q7m3 30 16 the the DT cord-323404-3mw4q7m3 30 17 normal normal JJ cord-323404-3mw4q7m3 30 18 epithelial epithelial JJ cord-323404-3mw4q7m3 30 19 signalling signalling NN cord-323404-3mw4q7m3 30 20 and and CC cord-323404-3mw4q7m3 30 21 trafficking traffic VBG cord-323404-3mw4q7m3 30 22 pathways pathway NNS cord-323404-3mw4q7m3 30 23 of of IN cord-323404-3mw4q7m3 30 24 the the DT cord-323404-3mw4q7m3 30 25 host host NN cord-323404-3mw4q7m3 30 26 cell cell NN cord-323404-3mw4q7m3 30 27 . . . cord-323404-3mw4q7m3 31 1 In in IN cord-323404-3mw4q7m3 31 2 addition addition NN cord-323404-3mw4q7m3 31 3 to to IN cord-323404-3mw4q7m3 31 4 protein protein NN cord-323404-3mw4q7m3 31 5 receptors receptor NNS cord-323404-3mw4q7m3 31 6 , , , cord-323404-3mw4q7m3 31 7 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 31 8 chains chain NNS cord-323404-3mw4q7m3 31 9 of of IN cord-323404-3mw4q7m3 31 10 proteoglycans proteoglycan NNS cord-323404-3mw4q7m3 31 11 and and CC cord-323404-3mw4q7m3 31 12 epithelial epithelial JJ cord-323404-3mw4q7m3 31 13 - - HYPH cord-323404-3mw4q7m3 31 14 membrane membrane NN cord-323404-3mw4q7m3 31 15 glycosphingolipids glycosphingolipid NNS cord-323404-3mw4q7m3 31 16 have have VBP cord-323404-3mw4q7m3 31 17 emerged emerge VBN cord-323404-3mw4q7m3 31 18 as as IN cord-323404-3mw4q7m3 31 19 a a DT cord-323404-3mw4q7m3 31 20 new new JJ cord-323404-3mw4q7m3 31 21 class class NN cord-323404-3mw4q7m3 31 22 of of IN cord-323404-3mw4q7m3 31 23 receptors receptor NNS cord-323404-3mw4q7m3 31 24 for for IN cord-323404-3mw4q7m3 31 25 viral viral JJ cord-323404-3mw4q7m3 31 26 attachment attachment NN cord-323404-3mw4q7m3 31 27 to to IN cord-323404-3mw4q7m3 31 28 the the DT cord-323404-3mw4q7m3 31 29 host host NN cord-323404-3mw4q7m3 31 30 cell cell NN cord-323404-3mw4q7m3 31 31 . . . cord-323404-3mw4q7m3 32 1 surface surface NN cord-323404-3mw4q7m3 32 2 protein protein NN cord-323404-3mw4q7m3 32 3 that that WDT cord-323404-3mw4q7m3 32 4 is be VBZ cord-323404-3mw4q7m3 32 5 present present JJ cord-323404-3mw4q7m3 32 6 in in IN cord-323404-3mw4q7m3 32 7 latently latently RB cord-323404-3mw4q7m3 32 8 infected infected JJ cord-323404-3mw4q7m3 32 9 people people NNS cord-323404-3mw4q7m3 32 10 . . . cord-323404-3mw4q7m3 33 1 The the DT cord-323404-3mw4q7m3 33 2 complex complex NN cord-323404-3mw4q7m3 33 3 binds bind VBZ cord-323404-3mw4q7m3 33 4 to to IN cord-323404-3mw4q7m3 33 5 the the DT cord-323404-3mw4q7m3 33 6 POLY POLY NNP cord-323404-3mw4q7m3 33 7 - - HYPH cord-323404-3mw4q7m3 33 8 IMMUNOGLOBULIN immunoglobulin NN cord-323404-3mw4q7m3 33 9 RECEPTOR receptor NN cord-323404-3mw4q7m3 33 10 at at IN cord-323404-3mw4q7m3 33 11 the the DT cord-323404-3mw4q7m3 33 12 basal basal NN cord-323404-3mw4q7m3 33 13 surface surface NN cord-323404-3mw4q7m3 33 14 of of IN cord-323404-3mw4q7m3 33 15 epithelial epithelial JJ cord-323404-3mw4q7m3 33 16 cells cell NNS cord-323404-3mw4q7m3 33 17 , , , cord-323404-3mw4q7m3 33 18 and and CC cord-323404-3mw4q7m3 33 19 is be VBZ cord-323404-3mw4q7m3 33 20 endocytosed endocytose VBN cord-323404-3mw4q7m3 33 21 and and CC cord-323404-3mw4q7m3 33 22 delivered deliver VBN cord-323404-3mw4q7m3 33 23 apically apically RB cord-323404-3mw4q7m3 33 24 without without IN cord-323404-3mw4q7m3 33 25 infection infection NN cord-323404-3mw4q7m3 33 26 6 6 CD cord-323404-3mw4q7m3 33 27 . . . cord-323404-3mw4q7m3 34 1 By by IN cord-323404-3mw4q7m3 34 2 contrast contrast NN cord-323404-3mw4q7m3 34 3 , , , cord-323404-3mw4q7m3 34 4 in in IN cord-323404-3mw4q7m3 34 5 non non JJ cord-323404-3mw4q7m3 34 6 - - JJ cord-323404-3mw4q7m3 34 7 polarized polarized JJ cord-323404-3mw4q7m3 34 8 cells cell NNS cord-323404-3mw4q7m3 34 9 , , , cord-323404-3mw4q7m3 34 10 the the DT cord-323404-3mw4q7m3 34 11 entry entry NN cord-323404-3mw4q7m3 34 12 of of IN cord-323404-3mw4q7m3 34 13 IgA IgA NNP cord-323404-3mw4q7m3 34 14 - - HYPH cord-323404-3mw4q7m3 34 15 EBV EBV NNP cord-323404-3mw4q7m3 34 16 leads lead VBZ cord-323404-3mw4q7m3 34 17 to to IN cord-323404-3mw4q7m3 34 18 infection infection NN cord-323404-3mw4q7m3 34 19 . . . cord-323404-3mw4q7m3 35 1 Two two CD cord-323404-3mw4q7m3 35 2 EBV EBV NNP cord-323404-3mw4q7m3 35 3 replicative replicative JJ cord-323404-3mw4q7m3 35 4 proteins protein NNS cord-323404-3mw4q7m3 35 5 can can MD cord-323404-3mw4q7m3 35 6 stimulate stimulate VB cord-323404-3mw4q7m3 35 7 the the DT cord-323404-3mw4q7m3 35 8 production production NN cord-323404-3mw4q7m3 35 9 of of IN cord-323404-3mw4q7m3 35 10 anti anti JJ cord-323404-3mw4q7m3 35 11 - - JJ cord-323404-3mw4q7m3 35 12 EBV EBV NNP cord-323404-3mw4q7m3 35 13 IgA IgA NNP cord-323404-3mw4q7m3 35 14 7 7 CD cord-323404-3mw4q7m3 35 15 , , , cord-323404-3mw4q7m3 35 16 8 8 CD cord-323404-3mw4q7m3 35 17 , , , cord-323404-3mw4q7m3 35 18 thereby thereby RB cord-323404-3mw4q7m3 35 19 contributing contribute VBG cord-323404-3mw4q7m3 35 20 to to IN cord-323404-3mw4q7m3 35 21 the the DT cord-323404-3mw4q7m3 35 22 development development NN cord-323404-3mw4q7m3 35 23 of of IN cord-323404-3mw4q7m3 35 24 disease disease NN cord-323404-3mw4q7m3 35 25 in in IN cord-323404-3mw4q7m3 35 26 latently latently RB cord-323404-3mw4q7m3 35 27 infected infected JJ cord-323404-3mw4q7m3 35 28 people people NNS cord-323404-3mw4q7m3 35 29 . . . cord-323404-3mw4q7m3 36 1 Finally finally RB cord-323404-3mw4q7m3 36 2 , , , cord-323404-3mw4q7m3 36 3 Peyer Peyer NNP cord-323404-3mw4q7m3 36 4 's 's POS cord-323404-3mw4q7m3 36 5 patches patch NNS cord-323404-3mw4q7m3 36 6 -specific -specific JJ cord-323404-3mw4q7m3 36 7 lymphoid lymphoid JJ cord-323404-3mw4q7m3 36 8 areas area NNS cord-323404-3mw4q7m3 36 9 of of IN cord-323404-3mw4q7m3 36 10 the the DT cord-323404-3mw4q7m3 36 11 gastrointestinal gastrointestinal JJ cord-323404-3mw4q7m3 36 12 tract tract NN cord-323404-3mw4q7m3 36 13 -are -are : cord-323404-3mw4q7m3 36 14 covered cover VBN cord-323404-3mw4q7m3 36 15 by by IN cord-323404-3mw4q7m3 36 16 specialized specialized JJ cord-323404-3mw4q7m3 36 17 epithelial epithelial JJ cord-323404-3mw4q7m3 36 18 cells cell NNS cord-323404-3mw4q7m3 36 19 , , , cord-323404-3mw4q7m3 36 20 which which WDT cord-323404-3mw4q7m3 36 21 are be VBP cord-323404-3mw4q7m3 36 22 known know VBN cord-323404-3mw4q7m3 36 23 as as IN cord-323404-3mw4q7m3 36 24 M M NNP cord-323404-3mw4q7m3 36 25 CELLS cell NNS cord-323404-3mw4q7m3 36 26 . . . cord-323404-3mw4q7m3 37 1 These these DT cord-323404-3mw4q7m3 37 2 patches patch NNS cord-323404-3mw4q7m3 37 3 might may MD cord-323404-3mw4q7m3 37 4 be be VB cord-323404-3mw4q7m3 37 5 one one CD cord-323404-3mw4q7m3 37 6 portal portal NN cord-323404-3mw4q7m3 37 7 for for IN cord-323404-3mw4q7m3 37 8 the the DT cord-323404-3mw4q7m3 37 9 mucosal mucosal JJ cord-323404-3mw4q7m3 37 10 entry entry NN cord-323404-3mw4q7m3 37 11 of of IN cord-323404-3mw4q7m3 37 12 poliovirus poliovirus NN cord-323404-3mw4q7m3 37 13 9 9 CD cord-323404-3mw4q7m3 37 14 , , , cord-323404-3mw4q7m3 37 15 HIV-1 HIV-1 NNP cord-323404-3mw4q7m3 37 16 10 10 CD cord-323404-3mw4q7m3 37 17 and and CC cord-323404-3mw4q7m3 37 18 reovirus reovirus NNP cord-323404-3mw4q7m3 37 19 11 11 CD cord-323404-3mw4q7m3 37 20 , , , cord-323404-3mw4q7m3 37 21 by by IN cord-323404-3mw4q7m3 37 22 transcytosis transcytosis NNP cord-323404-3mw4q7m3 37 23 across across IN cord-323404-3mw4q7m3 37 24 M M NNP cord-323404-3mw4q7m3 37 25 cells cell NNS cord-323404-3mw4q7m3 37 26 in in IN cord-323404-3mw4q7m3 37 27 a a DT cord-323404-3mw4q7m3 37 28 receptor receptor NN cord-323404-3mw4q7m3 37 29 - - HYPH cord-323404-3mw4q7m3 37 30 mediated mediate VBN cord-323404-3mw4q7m3 37 31 fashion fashion NN cord-323404-3mw4q7m3 37 32 . . . cord-323404-3mw4q7m3 38 1 Viruses virus NNS cord-323404-3mw4q7m3 38 2 can can MD cord-323404-3mw4q7m3 38 3 penetrate penetrate VB cord-323404-3mw4q7m3 38 4 epithelial epithelial JJ cord-323404-3mw4q7m3 38 5 cells cell NNS cord-323404-3mw4q7m3 38 6 at at IN cord-323404-3mw4q7m3 38 7 the the DT cord-323404-3mw4q7m3 38 8 epithelial epithelial JJ cord-323404-3mw4q7m3 38 9 - - HYPH cord-323404-3mw4q7m3 38 10 cell cell NN cord-323404-3mw4q7m3 38 11 plasma plasma NN cord-323404-3mw4q7m3 38 12 membrane membrane NN cord-323404-3mw4q7m3 38 13 directly directly RB cord-323404-3mw4q7m3 38 14 after after IN cord-323404-3mw4q7m3 38 15 attachment attachment NN cord-323404-3mw4q7m3 38 16 and and CC cord-323404-3mw4q7m3 38 17 fusion fusion NN cord-323404-3mw4q7m3 38 18 . . . cord-323404-3mw4q7m3 39 1 In in IN cord-323404-3mw4q7m3 39 2 polarized polarized JJ cord-323404-3mw4q7m3 39 3 monostratified monostratified JJ cord-323404-3mw4q7m3 39 4 epithelium epithelium NN cord-323404-3mw4q7m3 39 5 -where -where RB cord-323404-3mw4q7m3 40 1 the the DT cord-323404-3mw4q7m3 40 2 plasma plasma NN cord-323404-3mw4q7m3 40 3 membrane membrane NN cord-323404-3mw4q7m3 40 4 is be VBZ cord-323404-3mw4q7m3 40 5 divided divide VBN cord-323404-3mw4q7m3 40 6 into into IN cord-323404-3mw4q7m3 40 7 two two CD cord-323404-3mw4q7m3 40 8 domains domain NNS cord-323404-3mw4q7m3 40 9 that that WDT cord-323404-3mw4q7m3 40 10 have have VBP cord-323404-3mw4q7m3 40 11 a a DT cord-323404-3mw4q7m3 40 12 different different JJ cord-323404-3mw4q7m3 40 13 lipid lipid NN cord-323404-3mw4q7m3 40 14 and and CC cord-323404-3mw4q7m3 40 15 protein protein NN cord-323404-3mw4q7m3 40 16 composition composition NN cord-323404-3mw4q7m3 40 17 and and CC cord-323404-3mw4q7m3 40 18 different different JJ cord-323404-3mw4q7m3 40 19 membrane membrane NN cord-323404-3mw4q7m3 40 20 dynamics dynamic NNS cord-323404-3mw4q7m3 40 21 -viruses -viruses : cord-323404-3mw4q7m3 40 22 usually usually RB cord-323404-3mw4q7m3 40 23 attach attach VB cord-323404-3mw4q7m3 40 24 and and CC cord-323404-3mw4q7m3 40 25 penetrate penetrate VB cord-323404-3mw4q7m3 40 26 the the DT cord-323404-3mw4q7m3 40 27 cell cell NN cord-323404-3mw4q7m3 40 28 cytosol cytosol NN cord-323404-3mw4q7m3 40 29 preferentially preferentially RB cord-323404-3mw4q7m3 40 30 at at IN cord-323404-3mw4q7m3 40 31 the the DT cord-323404-3mw4q7m3 40 32 restricted restricted JJ cord-323404-3mw4q7m3 40 33 pole pole NN cord-323404-3mw4q7m3 40 34 of of IN cord-323404-3mw4q7m3 40 35 the the DT cord-323404-3mw4q7m3 40 36 by by IN cord-323404-3mw4q7m3 40 37 epithelial epithelial JJ cord-323404-3mw4q7m3 40 38 cells cell NNS cord-323404-3mw4q7m3 40 39 and and CC cord-323404-3mw4q7m3 40 40 cross cross VB cord-323404-3mw4q7m3 40 41 the the DT cord-323404-3mw4q7m3 40 42 epithelial epithelial JJ cord-323404-3mw4q7m3 40 43 barrier barrier NN cord-323404-3mw4q7m3 40 44 using use VBG cord-323404-3mw4q7m3 40 45 TRANSCYTOSIS TRANSCYTOSIS NNP cord-323404-3mw4q7m3 40 46 ( ( -LRB- cord-323404-3mw4q7m3 40 47 BOX BOX NNP cord-323404-3mw4q7m3 40 48 1 1 CD cord-323404-3mw4q7m3 40 49 ) ) -RRB- cord-323404-3mw4q7m3 40 50 , , , cord-323404-3mw4q7m3 40 51 as as IN cord-323404-3mw4q7m3 40 52 has have VBZ cord-323404-3mw4q7m3 40 53 been be VBN cord-323404-3mw4q7m3 40 54 described describe VBN cord-323404-3mw4q7m3 40 55 recently recently RB cord-323404-3mw4q7m3 40 56 for for IN cord-323404-3mw4q7m3 40 57 the the DT cord-323404-3mw4q7m3 40 58 human human JJ cord-323404-3mw4q7m3 40 59 immunodeficiency immunodeficiency NN cord-323404-3mw4q7m3 40 60 virus virus NN cord-323404-3mw4q7m3 40 61 ( ( -LRB- cord-323404-3mw4q7m3 40 62 HIV HIV NNP cord-323404-3mw4q7m3 40 63 ) ) -RRB- cord-323404-3mw4q7m3 40 64 3 3 CD cord-323404-3mw4q7m3 40 65 , , , cord-323404-3mw4q7m3 40 66 4 4 CD cord-323404-3mw4q7m3 40 67 . . . cord-323404-3mw4q7m3 41 1 In in IN cord-323404-3mw4q7m3 41 2 viruses virus NNS cord-323404-3mw4q7m3 41 3 , , , cord-323404-3mw4q7m3 41 4 the the DT cord-323404-3mw4q7m3 41 5 genome genome NN cord-323404-3mw4q7m3 41 6 is be VBZ cord-323404-3mw4q7m3 41 7 surrounded surround VBN cord-323404-3mw4q7m3 41 8 either either RB cord-323404-3mw4q7m3 41 9 solely solely RB cord-323404-3mw4q7m3 41 10 by by IN cord-323404-3mw4q7m3 41 11 a a DT cord-323404-3mw4q7m3 41 12 capsid capsid NN cord-323404-3mw4q7m3 41 13 ( ( -LRB- cord-323404-3mw4q7m3 41 14 ' ' `` cord-323404-3mw4q7m3 41 15 naked naked JJ cord-323404-3mw4q7m3 41 16 ' ' '' cord-323404-3mw4q7m3 41 17 virus virus NN cord-323404-3mw4q7m3 41 18 ) ) -RRB- cord-323404-3mw4q7m3 41 19 , , , cord-323404-3mw4q7m3 41 20 or or CC cord-323404-3mw4q7m3 41 21 by by IN cord-323404-3mw4q7m3 41 22 both both CC cord-323404-3mw4q7m3 41 23 a a DT cord-323404-3mw4q7m3 41 24 capsid capsid NN cord-323404-3mw4q7m3 41 25 and and CC cord-323404-3mw4q7m3 41 26 a a DT cord-323404-3mw4q7m3 41 27 membrane membrane NN cord-323404-3mw4q7m3 41 28 ( ( -LRB- cord-323404-3mw4q7m3 41 29 ' ' `` cord-323404-3mw4q7m3 41 30 enveloped envelop VBN cord-323404-3mw4q7m3 41 31 ' ' '' cord-323404-3mw4q7m3 41 32 virus virus NN cord-323404-3mw4q7m3 41 33 ; ; : cord-323404-3mw4q7m3 41 34 BOX BOX NNP cord-323404-3mw4q7m3 41 35 2 2 CD cord-323404-3mw4q7m3 41 36 ) ) -RRB- cord-323404-3mw4q7m3 41 37 . . . cord-323404-3mw4q7m3 42 1 We -PRON- PRP cord-323404-3mw4q7m3 42 2 know know VBP cord-323404-3mw4q7m3 42 3 much much JJ cord-323404-3mw4q7m3 42 4 about about IN cord-323404-3mw4q7m3 42 5 the the DT cord-323404-3mw4q7m3 42 6 entry entry NN cord-323404-3mw4q7m3 42 7 mechanism mechanism NN cord-323404-3mw4q7m3 42 8 of of IN cord-323404-3mw4q7m3 42 9 enveloped envelop VBN cord-323404-3mw4q7m3 42 10 viruses virus NNS cord-323404-3mw4q7m3 42 11 , , , cord-323404-3mw4q7m3 42 12 but but CC cord-323404-3mw4q7m3 42 13 the the DT cord-323404-3mw4q7m3 42 14 mechanism mechanism NN cord-323404-3mw4q7m3 42 15 by by IN cord-323404-3mw4q7m3 42 16 which which WDT cord-323404-3mw4q7m3 42 17 naked naked JJ cord-323404-3mw4q7m3 42 18 viruses virus NNS cord-323404-3mw4q7m3 42 19 penetrate penetrate VBP cord-323404-3mw4q7m3 42 20 epithelial epithelial JJ cord-323404-3mw4q7m3 42 21 cells cell NNS cord-323404-3mw4q7m3 42 22 is be VBZ cord-323404-3mw4q7m3 42 23 far far RB cord-323404-3mw4q7m3 42 24 less less RBR cord-323404-3mw4q7m3 42 25 well well RB cord-323404-3mw4q7m3 42 26 understood understand VBN cord-323404-3mw4q7m3 42 27 . . . cord-323404-3mw4q7m3 43 1 Nevertheless nevertheless RB cord-323404-3mw4q7m3 43 2 , , , cord-323404-3mw4q7m3 43 3 the the DT cord-323404-3mw4q7m3 43 4 route route NN cord-323404-3mw4q7m3 43 5 by by IN cord-323404-3mw4q7m3 43 6 which which WDT cord-323404-3mw4q7m3 43 7 viruses virus NNS cord-323404-3mw4q7m3 43 8 enter enter VBP cord-323404-3mw4q7m3 43 9 and and CC cord-323404-3mw4q7m3 43 10 then then RB cord-323404-3mw4q7m3 43 11 infect infect VB cord-323404-3mw4q7m3 43 12 or or CC cord-323404-3mw4q7m3 43 13 cross cross VB cord-323404-3mw4q7m3 43 14 epithelial epithelial JJ cord-323404-3mw4q7m3 43 15 cells cell NNS cord-323404-3mw4q7m3 43 16 is be VBZ cord-323404-3mw4q7m3 43 17 not not RB cord-323404-3mw4q7m3 43 18 dictated dictate VBN cord-323404-3mw4q7m3 43 19 solely solely RB cord-323404-3mw4q7m3 43 20 by by IN cord-323404-3mw4q7m3 43 21 whether whether IN cord-323404-3mw4q7m3 43 22 or or CC cord-323404-3mw4q7m3 43 23 not not RB cord-323404-3mw4q7m3 43 24 the the DT cord-323404-3mw4q7m3 43 25 virus virus NN cord-323404-3mw4q7m3 43 26 is be VBZ cord-323404-3mw4q7m3 43 27 enveloped envelop VBN cord-323404-3mw4q7m3 43 28 2,5 2,5 CD cord-323404-3mw4q7m3 43 29 , , , cord-323404-3mw4q7m3 43 30 and and CC cord-323404-3mw4q7m3 43 31 the the DT cord-323404-3mw4q7m3 43 32 three three CD cord-323404-3mw4q7m3 43 33 main main JJ cord-323404-3mw4q7m3 43 34 modes mode NNS cord-323404-3mw4q7m3 43 35 of of IN cord-323404-3mw4q7m3 43 36 entry entry NN cord-323404-3mw4q7m3 43 37 are be VBP cord-323404-3mw4q7m3 43 38 summarized summarize VBN cord-323404-3mw4q7m3 43 39 in in IN cord-323404-3mw4q7m3 43 40 the the DT cord-323404-3mw4q7m3 43 41 text text NN cord-323404-3mw4q7m3 43 42 below below IN cord-323404-3mw4q7m3 43 43 ( ( -LRB- cord-323404-3mw4q7m3 43 44 TABLE TABLE NNP cord-323404-3mw4q7m3 43 45 1 1 CD cord-323404-3mw4q7m3 43 46 ) ) -RRB- cord-323404-3mw4q7m3 43 47 . . . cord-323404-3mw4q7m3 44 1 Several several JJ cord-323404-3mw4q7m3 44 2 enveloped envelop VBN cord-323404-3mw4q7m3 44 3 and and CC cord-323404-3mw4q7m3 44 4 naked naked JJ cord-323404-3mw4q7m3 44 5 viruses virus NNS cord-323404-3mw4q7m3 44 6 , , , cord-323404-3mw4q7m3 44 7 such such JJ cord-323404-3mw4q7m3 44 8 as as IN cord-323404-3mw4q7m3 44 9 HIV-1 HIV-1 NNP cord-323404-3mw4q7m3 44 10 ( ( -LRB- cord-323404-3mw4q7m3 44 11 FIG FIG NNP cord-323404-3mw4q7m3 44 12 . . . cord-323404-3mw4q7m3 44 13 2 2 CD cord-323404-3mw4q7m3 44 14 ) ) -RRB- cord-323404-3mw4q7m3 44 15 and and CC cord-323404-3mw4q7m3 44 16 poliovirus poliovirus NN cord-323404-3mw4q7m3 44 17 , , , cord-323404-3mw4q7m3 44 18 cross cross VB cord-323404-3mw4q7m3 44 19 simple simple JJ cord-323404-3mw4q7m3 44 20 epithelial epithelial JJ cord-323404-3mw4q7m3 44 21 cells cell NNS cord-323404-3mw4q7m3 44 22 by by IN cord-323404-3mw4q7m3 44 23 rapid rapid JJ cord-323404-3mw4q7m3 44 24 transcytosis transcytosis NNP cord-323404-3mw4q7m3 44 25 without without IN cord-323404-3mw4q7m3 44 26 infection infection NN cord-323404-3mw4q7m3 44 27 . . . cord-323404-3mw4q7m3 45 1 They -PRON- PRP cord-323404-3mw4q7m3 45 2 are be VBP cord-323404-3mw4q7m3 45 3 released release VBN cord-323404-3mw4q7m3 45 4 -and -and : cord-323404-3mw4q7m3 45 5 are be VBP cord-323404-3mw4q7m3 45 6 still still RB cord-323404-3mw4q7m3 45 7 infectious infectious JJ cord-323404-3mw4q7m3 45 8 -at -at . cord-323404-3mw4q7m3 46 1 the the DT cord-323404-3mw4q7m3 46 2 pole pole NN cord-323404-3mw4q7m3 46 3 of of IN cord-323404-3mw4q7m3 46 4 the the DT cord-323404-3mw4q7m3 46 5 cell cell NN cord-323404-3mw4q7m3 46 6 that that WDT cord-323404-3mw4q7m3 46 7 is be VBZ cord-323404-3mw4q7m3 46 8 opposite opposite JJ cord-323404-3mw4q7m3 46 9 to to IN cord-323404-3mw4q7m3 46 10 their -PRON- PRP$ cord-323404-3mw4q7m3 46 11 pole pole NN cord-323404-3mw4q7m3 46 12 of of IN cord-323404-3mw4q7m3 46 13 entry entry NN cord-323404-3mw4q7m3 46 14 , , , cord-323404-3mw4q7m3 46 15 and and CC cord-323404-3mw4q7m3 46 16 this this DT cord-323404-3mw4q7m3 46 17 enables enable VBZ cord-323404-3mw4q7m3 46 18 the the DT cord-323404-3mw4q7m3 46 19 virus virus NN cord-323404-3mw4q7m3 46 20 to to TO cord-323404-3mw4q7m3 46 21 spread spread VB cord-323404-3mw4q7m3 46 22 in in IN cord-323404-3mw4q7m3 46 23 the the DT cord-323404-3mw4q7m3 46 24 submucosa submucosa NN cord-323404-3mw4q7m3 46 25 . . . cord-323404-3mw4q7m3 47 1 The the DT cord-323404-3mw4q7m3 47 2 Epstein Epstein NNP cord-323404-3mw4q7m3 47 3 - - HYPH cord-323404-3mw4q7m3 47 4 Barr Barr NNP cord-323404-3mw4q7m3 47 5 virus virus NN cord-323404-3mw4q7m3 47 6 ( ( -LRB- cord-323404-3mw4q7m3 47 7 EBV EBV NNP cord-323404-3mw4q7m3 47 8 ) ) -RRB- cord-323404-3mw4q7m3 47 9 uses use VBZ cord-323404-3mw4q7m3 47 10 a a DT cord-323404-3mw4q7m3 47 11 more more RBR cord-323404-3mw4q7m3 47 12 complicated complicated JJ cord-323404-3mw4q7m3 47 13 strategy strategy NN cord-323404-3mw4q7m3 47 14 . . . cord-323404-3mw4q7m3 48 1 EBV EBV NNP cord-323404-3mw4q7m3 48 2 forms form VBZ cord-323404-3mw4q7m3 48 3 a a DT cord-323404-3mw4q7m3 48 4 complex complex NN cord-323404-3mw4q7m3 48 5 with with IN cord-323404-3mw4q7m3 48 6 mucosal mucosal JJ cord-323404-3mw4q7m3 48 7 immunoglobulin immunoglobulin NN cord-323404-3mw4q7m3 48 8 ( ( -LRB- cord-323404-3mw4q7m3 49 1 Ig)A Ig)A NNP cord-323404-3mw4q7m3 50 1 that that DT cord-323404-3mw4q7m3 50 2 is be VBZ cord-323404-3mw4q7m3 50 3 specific specific JJ cord-323404-3mw4q7m3 50 4 for for IN cord-323404-3mw4q7m3 50 5 gp350 gp350 NNP cord-323404-3mw4q7m3 50 6 , , , cord-323404-3mw4q7m3 50 7 a a DT cord-323404-3mw4q7m3 50 8 viral viral JJ cord-323404-3mw4q7m3 50 9 TRANSCYTOSIS TRANSCYTOSIS NNP cord-323404-3mw4q7m3 50 10 A a DT cord-323404-3mw4q7m3 50 11 rapid rapid JJ cord-323404-3mw4q7m3 50 12 and and CC cord-323404-3mw4q7m3 50 13 selective selective JJ cord-323404-3mw4q7m3 50 14 vesicular vesicular JJ cord-323404-3mw4q7m3 50 15 transcellular transcellular NNP cord-323404-3mw4q7m3 50 16 pathway pathway NN cord-323404-3mw4q7m3 50 17 that that WDT cord-323404-3mw4q7m3 50 18 is be VBZ cord-323404-3mw4q7m3 50 19 characteristic characteristic JJ cord-323404-3mw4q7m3 50 20 of of IN cord-323404-3mw4q7m3 50 21 polarized polarized JJ cord-323404-3mw4q7m3 50 22 epithelia epithelium NNS cord-323404-3mw4q7m3 50 23 . . . cord-323404-3mw4q7m3 51 1 Cargo cargo NN cord-323404-3mw4q7m3 51 2 is be VBZ cord-323404-3mw4q7m3 51 3 transported transport VBN cord-323404-3mw4q7m3 51 4 from from IN cord-323404-3mw4q7m3 51 5 one one CD cord-323404-3mw4q7m3 51 6 pole pole NN cord-323404-3mw4q7m3 51 7 of of IN cord-323404-3mw4q7m3 51 8 the the DT cord-323404-3mw4q7m3 51 9 cell cell NN cord-323404-3mw4q7m3 51 10 to to IN cord-323404-3mw4q7m3 51 11 the the DT cord-323404-3mw4q7m3 51 12 opposite opposite JJ cord-323404-3mw4q7m3 51 13 pole pole NN cord-323404-3mw4q7m3 51 14 . . . cord-323404-3mw4q7m3 52 1 The the DT cord-323404-3mw4q7m3 52 2 cargo cargo NN cord-323404-3mw4q7m3 52 3 remains remain VBZ cord-323404-3mw4q7m3 52 4 enclosed enclose VBN cord-323404-3mw4q7m3 52 5 in in IN cord-323404-3mw4q7m3 52 6 transcytotic transcytotic JJ cord-323404-3mw4q7m3 52 7 vesicles vesicle NNS cord-323404-3mw4q7m3 52 8 , , , cord-323404-3mw4q7m3 52 9 which which WDT cord-323404-3mw4q7m3 52 10 precludes preclude VBZ cord-323404-3mw4q7m3 52 11 access access NN cord-323404-3mw4q7m3 52 12 to to IN cord-323404-3mw4q7m3 52 13 the the DT cord-323404-3mw4q7m3 52 14 cytosol cytosol NN cord-323404-3mw4q7m3 52 15 and and CC cord-323404-3mw4q7m3 52 16 therefore therefore RB cord-323404-3mw4q7m3 52 17 viral viral JJ cord-323404-3mw4q7m3 52 18 infection infection NN cord-323404-3mw4q7m3 52 19 of of IN cord-323404-3mw4q7m3 52 20 epithelial epithelial JJ cord-323404-3mw4q7m3 52 21 cells cell NNS cord-323404-3mw4q7m3 52 22 . . . cord-323404-3mw4q7m3 53 1 This this DT cord-323404-3mw4q7m3 53 2 receptor receptor NN cord-323404-3mw4q7m3 53 3 is be VBZ cord-323404-3mw4q7m3 53 4 expressed express VBN cord-323404-3mw4q7m3 53 5 at at IN cord-323404-3mw4q7m3 53 6 the the DT cord-323404-3mw4q7m3 53 7 basolateral basolateral JJ cord-323404-3mw4q7m3 53 8 surface surface NN cord-323404-3mw4q7m3 53 9 of of IN cord-323404-3mw4q7m3 53 10 epithelial epithelial JJ cord-323404-3mw4q7m3 53 11 cells cell NNS cord-323404-3mw4q7m3 53 12 , , , cord-323404-3mw4q7m3 53 13 allowing allow VBG cord-323404-3mw4q7m3 53 14 specific specific JJ cord-323404-3mw4q7m3 53 15 transcytosis transcytosis NN cord-323404-3mw4q7m3 53 16 towards towards IN cord-323404-3mw4q7m3 53 17 the the DT cord-323404-3mw4q7m3 53 18 apical apical JJ cord-323404-3mw4q7m3 53 19 pole pole NN cord-323404-3mw4q7m3 53 20 of of IN cord-323404-3mw4q7m3 53 21 mucosal mucosal JJ cord-323404-3mw4q7m3 53 22 dimeric dimeric JJ cord-323404-3mw4q7m3 53 23 IgA IgA NNP cord-323404-3mw4q7m3 53 24 or or CC cord-323404-3mw4q7m3 53 25 pentameric pentameric NN cord-323404-3mw4q7m3 53 26 IgM. IgM. NNP cord-323404-3mw4q7m3 54 1 At at IN cord-323404-3mw4q7m3 54 2 the the DT cord-323404-3mw4q7m3 54 3 apical apical JJ cord-323404-3mw4q7m3 54 4 pole pole NN cord-323404-3mw4q7m3 54 5 , , , cord-323404-3mw4q7m3 54 6 after after IN cord-323404-3mw4q7m3 54 7 cleavage cleavage NN cord-323404-3mw4q7m3 54 8 of of IN cord-323404-3mw4q7m3 54 9 the the DT cord-323404-3mw4q7m3 54 10 extracellular extracellular JJ cord-323404-3mw4q7m3 54 11 region region NN cord-323404-3mw4q7m3 54 12 of of IN cord-323404-3mw4q7m3 54 13 the the DT cord-323404-3mw4q7m3 54 14 receptor receptor NN cord-323404-3mw4q7m3 54 15 , , , cord-323404-3mw4q7m3 54 16 which which WDT cord-323404-3mw4q7m3 54 17 is be VBZ cord-323404-3mw4q7m3 54 18 known know VBN cord-323404-3mw4q7m3 54 19 as as IN cord-323404-3mw4q7m3 54 20 secretory secretory JJ cord-323404-3mw4q7m3 54 21 component component NN cord-323404-3mw4q7m3 54 22 ( ( -LRB- cord-323404-3mw4q7m3 54 23 SC SC NNP cord-323404-3mw4q7m3 54 24 ) ) -RRB- cord-323404-3mw4q7m3 54 25 , , , cord-323404-3mw4q7m3 54 26 the the DT cord-323404-3mw4q7m3 54 27 mucosal mucosal JJ cord-323404-3mw4q7m3 54 28 IgA IgA NNP cord-323404-3mw4q7m3 54 29 or or CC cord-323404-3mw4q7m3 54 30 IgM IgM NNP cord-323404-3mw4q7m3 54 31 is be VBZ cord-323404-3mw4q7m3 54 32 released release VBN cord-323404-3mw4q7m3 54 33 with with IN cord-323404-3mw4q7m3 54 34 SC SC NNP cord-323404-3mw4q7m3 54 35 as as IN cord-323404-3mw4q7m3 54 36 secretory secretory JJ cord-323404-3mw4q7m3 54 37 IgA IgA NNP cord-323404-3mw4q7m3 54 38 or or CC cord-323404-3mw4q7m3 54 39 IgM IgM NNP cord-323404-3mw4q7m3 54 40 , , , cord-323404-3mw4q7m3 54 41 and and CC cord-323404-3mw4q7m3 54 42 can can MD cord-323404-3mw4q7m3 54 43 act act VB cord-323404-3mw4q7m3 54 44 as as IN cord-323404-3mw4q7m3 54 45 the the DT cord-323404-3mw4q7m3 54 46 first first JJ cord-323404-3mw4q7m3 54 47 defence defence NN cord-323404-3mw4q7m3 54 48 against against IN cord-323404-3mw4q7m3 54 49 pathogens pathogen NNS cord-323404-3mw4q7m3 54 50 . . . cord-323404-3mw4q7m3 55 1 1 1 LS cord-323404-3mw4q7m3 55 2 | | NNP cord-323404-3mw4q7m3 55 3 Proteoglycans Proteoglycans NNPS cord-323404-3mw4q7m3 55 4 and and CC cord-323404-3mw4q7m3 55 5 glycosphingolipids glycosphingolipid NNS cord-323404-3mw4q7m3 55 6 . . . cord-323404-3mw4q7m3 56 1 a a LS cord-323404-3mw4q7m3 56 2 | | NNP cord-323404-3mw4q7m3 56 3 Proteoglycans Proteoglycans NNPS cord-323404-3mw4q7m3 56 4 are be VBP cord-323404-3mw4q7m3 56 5 proteins protein NNS cord-323404-3mw4q7m3 56 6 that that WDT cord-323404-3mw4q7m3 56 7 are be VBP cord-323404-3mw4q7m3 56 8 classified classify VBN cord-323404-3mw4q7m3 56 9 by by IN cord-323404-3mw4q7m3 56 10 a a DT cord-323404-3mw4q7m3 56 11 post post JJ cord-323404-3mw4q7m3 56 12 - - JJ cord-323404-3mw4q7m3 56 13 translational translational JJ cord-323404-3mw4q7m3 56 14 attachment attachment NN cord-323404-3mw4q7m3 56 15 of of IN cord-323404-3mw4q7m3 56 16 polysaccharide polysaccharide NN cord-323404-3mw4q7m3 56 17 glycosaminoglycan glycosaminoglycan NNP cord-323404-3mw4q7m3 56 18 moieties moiety NNS cord-323404-3mw4q7m3 56 19 , , , cord-323404-3mw4q7m3 56 20 which which WDT cord-323404-3mw4q7m3 56 21 are be VBP cord-323404-3mw4q7m3 56 22 each each DT cord-323404-3mw4q7m3 56 23 composed compose VBN cord-323404-3mw4q7m3 56 24 of of IN cord-323404-3mw4q7m3 56 25 repeating repeat VBG cord-323404-3mw4q7m3 56 26 disaccharide disaccharide JJ cord-323404-3mw4q7m3 56 27 units unit NNS cord-323404-3mw4q7m3 56 28 . . . cord-323404-3mw4q7m3 57 1 The the DT cord-323404-3mw4q7m3 57 2 ubiquitously ubiquitously RB cord-323404-3mw4q7m3 57 3 expressed express VBN cord-323404-3mw4q7m3 57 4 glycosaminoglycan glycosaminoglycan NNP cord-323404-3mw4q7m3 57 5 heparan heparan NN cord-323404-3mw4q7m3 57 6 sulphate sulphate NN cord-323404-3mw4q7m3 57 7 ( ( -LRB- cord-323404-3mw4q7m3 57 8 shown show VBN cord-323404-3mw4q7m3 57 9 here here RB cord-323404-3mw4q7m3 57 10 ) ) -RRB- cord-323404-3mw4q7m3 57 11 is be VBZ cord-323404-3mw4q7m3 57 12 highly highly RB cord-323404-3mw4q7m3 57 13 polymorphic polymorphic JJ cord-323404-3mw4q7m3 57 14 , , , cord-323404-3mw4q7m3 57 15 and and CC cord-323404-3mw4q7m3 57 16 its -PRON- PRP$ cord-323404-3mw4q7m3 57 17 sulphated sulphated JJ cord-323404-3mw4q7m3 57 18 structural structural JJ cord-323404-3mw4q7m3 57 19 motifs motif NNS cord-323404-3mw4q7m3 57 20 are be VBP cord-323404-3mw4q7m3 57 21 primarily primarily RB cord-323404-3mw4q7m3 57 22 responsible responsible JJ cord-323404-3mw4q7m3 57 23 for for IN cord-323404-3mw4q7m3 57 24 its -PRON- PRP$ cord-323404-3mw4q7m3 57 25 protein protein NN cord-323404-3mw4q7m3 57 26 binding binding NN cord-323404-3mw4q7m3 57 27 and and CC cord-323404-3mw4q7m3 57 28 regulatory regulatory JJ cord-323404-3mw4q7m3 57 29 properties property NNS cord-323404-3mw4q7m3 57 30 . . . cord-323404-3mw4q7m3 58 1 b b LS cord-323404-3mw4q7m3 58 2 | | NNP cord-323404-3mw4q7m3 58 3 Glycosphingolipids Glycosphingolipids NNP cord-323404-3mw4q7m3 58 4 are be VBP cord-323404-3mw4q7m3 58 5 anchored anchor VBN cord-323404-3mw4q7m3 58 6 in in IN cord-323404-3mw4q7m3 58 7 the the DT cord-323404-3mw4q7m3 58 8 outer outer JJ cord-323404-3mw4q7m3 58 9 leaflet leaflet NN cord-323404-3mw4q7m3 58 10 of of IN cord-323404-3mw4q7m3 58 11 the the DT cord-323404-3mw4q7m3 58 12 plasma plasma NN cord-323404-3mw4q7m3 58 13 - - HYPH cord-323404-3mw4q7m3 58 14 membrane membrane NN cord-323404-3mw4q7m3 58 15 bilayer bilayer NN cord-323404-3mw4q7m3 58 16 by by IN cord-323404-3mw4q7m3 58 17 their -PRON- PRP$ cord-323404-3mw4q7m3 58 18 common common JJ cord-323404-3mw4q7m3 58 19 hydrophobic hydrophobic JJ cord-323404-3mw4q7m3 58 20 backbone backbone NN cord-323404-3mw4q7m3 58 21 , , , cord-323404-3mw4q7m3 58 22 ceramide ceramide NN cord-323404-3mw4q7m3 58 23 , , , cord-323404-3mw4q7m3 58 24 which which WDT cord-323404-3mw4q7m3 58 25 consists consist VBZ cord-323404-3mw4q7m3 58 26 of of IN cord-323404-3mw4q7m3 58 27 a a DT cord-323404-3mw4q7m3 58 28 fatty fatty JJ cord-323404-3mw4q7m3 58 29 - - HYPH cord-323404-3mw4q7m3 58 30 acid acid NN cord-323404-3mw4q7m3 58 31 chain chain NN cord-323404-3mw4q7m3 58 32 linked link VBN cord-323404-3mw4q7m3 58 33 to to IN cord-323404-3mw4q7m3 58 34 the the DT cord-323404-3mw4q7m3 58 35 sphingosine sphingosine JJ cord-323404-3mw4q7m3 58 36 base base NN cord-323404-3mw4q7m3 58 37 . . . cord-323404-3mw4q7m3 59 1 The the DT cord-323404-3mw4q7m3 59 2 hydrophilic hydrophilic JJ cord-323404-3mw4q7m3 59 3 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 59 4 parts part NNS cord-323404-3mw4q7m3 59 5 of of IN cord-323404-3mw4q7m3 59 6 neutral neutral JJ cord-323404-3mw4q7m3 59 7 glycosphingolipids glycosphingolipid NNS cord-323404-3mw4q7m3 59 8 and and CC cord-323404-3mw4q7m3 59 9 gangliosides ganglioside NNS cord-323404-3mw4q7m3 59 10 protrude protrude VBP cord-323404-3mw4q7m3 59 11 into into IN cord-323404-3mw4q7m3 59 12 the the DT cord-323404-3mw4q7m3 59 13 extracellular extracellular JJ cord-323404-3mw4q7m3 59 14 space space NN cord-323404-3mw4q7m3 59 15 and and CC cord-323404-3mw4q7m3 59 16 partially partially RB cord-323404-3mw4q7m3 59 17 cover cover VB cord-323404-3mw4q7m3 59 18 the the DT cord-323404-3mw4q7m3 59 19 cell cell NN cord-323404-3mw4q7m3 59 20 surface surface NN cord-323404-3mw4q7m3 59 21 . . . cord-323404-3mw4q7m3 60 1 GalNAc GalNAc NNP cord-323404-3mw4q7m3 60 2 , , , cord-323404-3mw4q7m3 60 3 ( ( -LRB- cord-323404-3mw4q7m3 60 4 OSO OSO NNP cord-323404-3mw4q7m3 60 5 3 3 CD cord-323404-3mw4q7m3 60 6 ) ) -RRB- cord-323404-3mw4q7m3 60 7 , , , cord-323404-3mw4q7m3 60 8 N n CD cord-323404-3mw4q7m3 60 9 - - HYPH cord-323404-3mw4q7m3 60 10 acetyl acetyl NN cord-323404-3mw4q7m3 60 11 galactosamine galactosamine NN cord-323404-3mw4q7m3 60 12 sulphate sulphate NN cord-323404-3mw4q7m3 60 13 ; ; : cord-323404-3mw4q7m3 61 1 GlcNSO GlcNSO NNP cord-323404-3mw4q7m3 61 2 3 3 CD cord-323404-3mw4q7m3 61 3 , , , cord-323404-3mw4q7m3 61 4 glucosamine glucosamine NN cord-323404-3mw4q7m3 61 5 sulphate sulphate NN cord-323404-3mw4q7m3 61 6 ; ; : cord-323404-3mw4q7m3 61 7 GlcUA GlcUA NNP cord-323404-3mw4q7m3 61 8 , , , cord-323404-3mw4q7m3 61 9 glucuronic glucuronic JJ cord-323404-3mw4q7m3 61 10 acid acid NN cord-323404-3mw4q7m3 61 11 ; ; : cord-323404-3mw4q7m3 61 12 IdUA IdUA NNP cord-323404-3mw4q7m3 61 13 ( ( -LRB- cord-323404-3mw4q7m3 61 14 OSO OSO NNP cord-323404-3mw4q7m3 61 15 3 3 CD cord-323404-3mw4q7m3 61 16 ) ) -RRB- cord-323404-3mw4q7m3 61 17 , , , cord-323404-3mw4q7m3 61 18 iduronic iduronic JJ cord-323404-3mw4q7m3 61 19 acid acid NN cord-323404-3mw4q7m3 61 20 sulphate sulphate NN cord-323404-3mw4q7m3 61 21 . . . cord-323404-3mw4q7m3 62 1 Chondroitin-4-sulphate chondroitin-4-sulphate NN cord-323404-3mw4q7m3 62 2 epithelial epithelial JJ cord-323404-3mw4q7m3 62 3 cell cell NN cord-323404-3mw4q7m3 62 4 . . . cord-323404-3mw4q7m3 63 1 Some some DT cord-323404-3mw4q7m3 63 2 enveloped envelop VBN cord-323404-3mw4q7m3 63 3 viruses virus NNS cord-323404-3mw4q7m3 63 4 attach attach VBP cord-323404-3mw4q7m3 63 5 to to IN cord-323404-3mw4q7m3 63 6 , , , cord-323404-3mw4q7m3 63 7 and and CC cord-323404-3mw4q7m3 63 8 fuse fuse VB cord-323404-3mw4q7m3 63 9 with with IN cord-323404-3mw4q7m3 63 10 , , , cord-323404-3mw4q7m3 63 11 the the DT cord-323404-3mw4q7m3 63 12 epithelial epithelial JJ cord-323404-3mw4q7m3 63 13 - - HYPH cord-323404-3mw4q7m3 63 14 cell cell NN cord-323404-3mw4q7m3 63 15 apical apical JJ cord-323404-3mw4q7m3 63 16 membrane membrane NN cord-323404-3mw4q7m3 63 17 [ [ -LRB- cord-323404-3mw4q7m3 63 18 12 12 CD cord-323404-3mw4q7m3 63 19 ] ] -RRB- cord-323404-3mw4q7m3 63 20 [ [ -LRB- cord-323404-3mw4q7m3 63 21 13 13 CD cord-323404-3mw4q7m3 63 22 ] ] -RRB- cord-323404-3mw4q7m3 63 23 [ [ -LRB- cord-323404-3mw4q7m3 63 24 14 14 CD cord-323404-3mw4q7m3 63 25 ] ] -RRB- cord-323404-3mw4q7m3 63 26 , , , cord-323404-3mw4q7m3 63 27 whereas whereas IN cord-323404-3mw4q7m3 63 28 other other JJ cord-323404-3mw4q7m3 63 29 enveloped envelop VBD cord-323404-3mw4q7m3 63 30 viruses virus NNS cord-323404-3mw4q7m3 63 31 15 15 CD cord-323404-3mw4q7m3 63 32 attach attach NN cord-323404-3mw4q7m3 63 33 to to IN cord-323404-3mw4q7m3 63 34 , , , cord-323404-3mw4q7m3 63 35 and and CC cord-323404-3mw4q7m3 63 36 fuse fuse VB cord-323404-3mw4q7m3 63 37 with with IN cord-323404-3mw4q7m3 63 38 , , , cord-323404-3mw4q7m3 63 39 the the DT cord-323404-3mw4q7m3 63 40 basal basal NN cord-323404-3mw4q7m3 63 41 membrane membrane NN cord-323404-3mw4q7m3 63 42 . . . cord-323404-3mw4q7m3 64 1 Importantly importantly RB cord-323404-3mw4q7m3 64 2 , , , cord-323404-3mw4q7m3 64 3 viruses virus NNS cord-323404-3mw4q7m3 64 4 from from IN cord-323404-3mw4q7m3 64 5 the the DT cord-323404-3mw4q7m3 64 6 same same JJ cord-323404-3mw4q7m3 64 7 family family NN cord-323404-3mw4q7m3 64 8 do do VBP cord-323404-3mw4q7m3 64 9 not not RB cord-323404-3mw4q7m3 64 10 always always RB cord-323404-3mw4q7m3 64 11 show show VB cord-323404-3mw4q7m3 64 12 the the DT cord-323404-3mw4q7m3 64 13 same same JJ cord-323404-3mw4q7m3 64 14 polarity polarity NN cord-323404-3mw4q7m3 64 15 of of IN cord-323404-3mw4q7m3 64 16 entry entry NN cord-323404-3mw4q7m3 64 17 14 14 CD cord-323404-3mw4q7m3 64 18 , , , cord-323404-3mw4q7m3 64 19 16 16 CD cord-323404-3mw4q7m3 64 20 , , , cord-323404-3mw4q7m3 64 21 17 17 CD cord-323404-3mw4q7m3 64 22 . . . cord-323404-3mw4q7m3 65 1 This this DT cord-323404-3mw4q7m3 65 2 is be VBZ cord-323404-3mw4q7m3 65 3 due due JJ cord-323404-3mw4q7m3 65 4 , , , cord-323404-3mw4q7m3 65 5 in in IN cord-323404-3mw4q7m3 65 6 part part NN cord-323404-3mw4q7m3 65 7 , , , cord-323404-3mw4q7m3 65 8 to to IN cord-323404-3mw4q7m3 65 9 the the DT cord-323404-3mw4q7m3 65 10 use use NN cord-323404-3mw4q7m3 65 11 of of IN cord-323404-3mw4q7m3 65 12 different different JJ cord-323404-3mw4q7m3 65 13 cell cell NN cord-323404-3mw4q7m3 65 14 receptors receptor NNS cord-323404-3mw4q7m3 65 15 . . . cord-323404-3mw4q7m3 66 1 However however RB cord-323404-3mw4q7m3 66 2 , , , cord-323404-3mw4q7m3 66 3 some some DT cord-323404-3mw4q7m3 66 4 viruses virus NNS cord-323404-3mw4q7m3 66 5 such such JJ cord-323404-3mw4q7m3 66 6 as as IN cord-323404-3mw4q7m3 66 7 poliovirus poliovirus NN cord-323404-3mw4q7m3 66 8 can can MD cord-323404-3mw4q7m3 66 9 enter enter VB cord-323404-3mw4q7m3 66 10 at at IN cord-323404-3mw4q7m3 66 11 both both CC cord-323404-3mw4q7m3 66 12 the the DT cord-323404-3mw4q7m3 66 13 plasma plasma NN cord-323404-3mw4q7m3 66 14 membrane membrane NN cord-323404-3mw4q7m3 66 15 and and CC cord-323404-3mw4q7m3 66 16 through through IN cord-323404-3mw4q7m3 66 17 the the DT cord-323404-3mw4q7m3 66 18 endocytic endocytic JJ cord-323404-3mw4q7m3 66 19 pathway pathway NN cord-323404-3mw4q7m3 66 20 18 18 CD cord-323404-3mw4q7m3 66 21 , , , cord-323404-3mw4q7m3 66 22 19 19 CD cord-323404-3mw4q7m3 66 23 ( ( -LRB- cord-323404-3mw4q7m3 66 24 see see VB cord-323404-3mw4q7m3 66 25 below below RB cord-323404-3mw4q7m3 66 26 ) ) -RRB- cord-323404-3mw4q7m3 66 27 . . . cord-323404-3mw4q7m3 67 1 Both both DT cord-323404-3mw4q7m3 67 2 enveloped envelop VBN cord-323404-3mw4q7m3 67 3 and and CC cord-323404-3mw4q7m3 67 4 naked naked JJ cord-323404-3mw4q7m3 67 5 viruses virus NNS cord-323404-3mw4q7m3 67 6 can can MD cord-323404-3mw4q7m3 67 7 enter enter VB cord-323404-3mw4q7m3 67 8 epithelial epithelial JJ cord-323404-3mw4q7m3 67 9 cells cell NNS cord-323404-3mw4q7m3 67 10 by by IN cord-323404-3mw4q7m3 67 11 endocytosis endocytosis NN cord-323404-3mw4q7m3 67 12 , , , cord-323404-3mw4q7m3 67 13 and and CC cord-323404-3mw4q7m3 67 14 they -PRON- PRP cord-323404-3mw4q7m3 67 15 usually usually RB cord-323404-3mw4q7m3 67 16 penetrate penetrate VBP cord-323404-3mw4q7m3 67 17 the the DT cord-323404-3mw4q7m3 67 18 host host NN cord-323404-3mw4q7m3 67 19 - - HYPH cord-323404-3mw4q7m3 67 20 cell cell NN cord-323404-3mw4q7m3 67 21 cytosol cytosol NN cord-323404-3mw4q7m3 67 22 by by IN cord-323404-3mw4q7m3 67 23 fusion fusion NN cord-323404-3mw4q7m3 67 24 from from IN cord-323404-3mw4q7m3 67 25 an an DT cord-323404-3mw4q7m3 67 26 ENDOSOME ENDOSOME NNP cord-323404-3mw4q7m3 67 27 . . . cord-323404-3mw4q7m3 68 1 This this DT cord-323404-3mw4q7m3 68 2 mode mode NN cord-323404-3mw4q7m3 68 3 of of IN cord-323404-3mw4q7m3 68 4 entry entry NN cord-323404-3mw4q7m3 68 5 makes make VBZ cord-323404-3mw4q7m3 68 6 use use NN cord-323404-3mw4q7m3 68 7 of of IN cord-323404-3mw4q7m3 68 8 specific specific JJ cord-323404-3mw4q7m3 68 9 endosomal endosomal JJ cord-323404-3mw4q7m3 68 10 conditions condition NNS cord-323404-3mw4q7m3 68 11 such such JJ cord-323404-3mw4q7m3 68 12 as as IN cord-323404-3mw4q7m3 68 13 low low JJ cord-323404-3mw4q7m3 68 14 pH ph NN cord-323404-3mw4q7m3 68 15 or or CC cord-323404-3mw4q7m3 68 16 a a DT cord-323404-3mw4q7m3 68 17 high high JJ cord-323404-3mw4q7m3 68 18 concentration concentration NN cord-323404-3mw4q7m3 68 19 of of IN cord-323404-3mw4q7m3 68 20 calcium calcium NN cord-323404-3mw4q7m3 68 21 . . . cord-323404-3mw4q7m3 69 1 In in IN cord-323404-3mw4q7m3 69 2 polarized polarized JJ cord-323404-3mw4q7m3 69 3 monostratified monostratified JJ cord-323404-3mw4q7m3 69 4 epithelium epithelium NN cord-323404-3mw4q7m3 69 5 , , , cord-323404-3mw4q7m3 69 6 the the DT cord-323404-3mw4q7m3 69 7 polarity polarity NN cord-323404-3mw4q7m3 69 8 of of IN cord-323404-3mw4q7m3 69 9 viral viral JJ cord-323404-3mw4q7m3 69 10 entry entry NN cord-323404-3mw4q7m3 69 11 is be VBZ cord-323404-3mw4q7m3 69 12 a a DT cord-323404-3mw4q7m3 69 13 determinant determinant NN cord-323404-3mw4q7m3 69 14 for for IN cord-323404-3mw4q7m3 69 15 the the DT cord-323404-3mw4q7m3 69 16 outcome outcome NN cord-323404-3mw4q7m3 69 17 of of IN cord-323404-3mw4q7m3 69 18 an an DT cord-323404-3mw4q7m3 69 19 infection infection NN cord-323404-3mw4q7m3 69 20 , , , cord-323404-3mw4q7m3 69 21 as as IN cord-323404-3mw4q7m3 69 22 polarity polarity NN cord-323404-3mw4q7m3 69 23 differentially differentially RB cord-323404-3mw4q7m3 69 24 influences influence VBZ cord-323404-3mw4q7m3 69 25 the the DT cord-323404-3mw4q7m3 69 26 processing processing NN cord-323404-3mw4q7m3 69 27 and and CC cord-323404-3mw4q7m3 69 28 sorting sorting NN cord-323404-3mw4q7m3 69 29 mechanisms mechanism NNS cord-323404-3mw4q7m3 69 30 in in IN cord-323404-3mw4q7m3 69 31 apical apical JJ cord-323404-3mw4q7m3 69 32 and and CC cord-323404-3mw4q7m3 69 33 basolateral basolateral JJ cord-323404-3mw4q7m3 69 34 endosomes endosome NNS cord-323404-3mw4q7m3 69 35 . . . cord-323404-3mw4q7m3 70 1 However however RB cord-323404-3mw4q7m3 70 2 , , , cord-323404-3mw4q7m3 70 3 the the DT cord-323404-3mw4q7m3 70 4 nature nature NN cord-323404-3mw4q7m3 70 5 of of IN cord-323404-3mw4q7m3 70 6 the the DT cord-323404-3mw4q7m3 70 7 experimental experimental JJ cord-323404-3mw4q7m3 70 8 system system NN cord-323404-3mw4q7m3 70 9 can can MD cord-323404-3mw4q7m3 70 10 change change VB cord-323404-3mw4q7m3 70 11 the the DT cord-323404-3mw4q7m3 70 12 polarity polarity NN cord-323404-3mw4q7m3 70 13 of of IN cord-323404-3mw4q7m3 70 14 viral viral JJ cord-323404-3mw4q7m3 70 15 entry entry NN cord-323404-3mw4q7m3 70 16 20 20 CD cord-323404-3mw4q7m3 70 17 _SP cord-323404-3mw4q7m3 70 18 . . . cord-323404-3mw4q7m3 71 1 Some some DT cord-323404-3mw4q7m3 71 2 enveloped envelop VBN cord-323404-3mw4q7m3 71 3 viruses virus NNS cord-323404-3mw4q7m3 71 4 , , , cord-323404-3mw4q7m3 71 5 such such JJ cord-323404-3mw4q7m3 71 6 as as IN cord-323404-3mw4q7m3 71 7 influenza influenza NN cord-323404-3mw4q7m3 71 8 virus virus NN cord-323404-3mw4q7m3 71 9 types type VBZ cord-323404-3mw4q7m3 71 10 A A NNP cord-323404-3mw4q7m3 71 11 and and CC cord-323404-3mw4q7m3 71 12 C c NN cord-323404-3mw4q7m3 71 13 , , , cord-323404-3mw4q7m3 71 14 bovine bovine JJ cord-323404-3mw4q7m3 71 15 coronavirus coronavirus NN cord-323404-3mw4q7m3 71 16 21 21 CD cord-323404-3mw4q7m3 71 17 and and CC cord-323404-3mw4q7m3 71 18 hepatitis hepatitis NN cord-323404-3mw4q7m3 71 19 A a DT cord-323404-3mw4q7m3 71 20 virus virus NN cord-323404-3mw4q7m3 71 21 ( ( -LRB- cord-323404-3mw4q7m3 71 22 HAV HAV NNP cord-323404-3mw4q7m3 71 23 ) ) -RRB- cord-323404-3mw4q7m3 71 24 22 22 CD cord-323404-3mw4q7m3 71 25 , , , cord-323404-3mw4q7m3 71 26 are be VBP cord-323404-3mw4q7m3 71 27 endocytosed endocytose VBN cord-323404-3mw4q7m3 71 28 at at IN cord-323404-3mw4q7m3 71 29 the the DT cord-323404-3mw4q7m3 71 30 apical apical JJ cord-323404-3mw4q7m3 71 31 pole pole NN cord-323404-3mw4q7m3 71 32 of of IN cord-323404-3mw4q7m3 71 33 polarized polarized JJ cord-323404-3mw4q7m3 71 34 epithelial epithelial JJ cord-323404-3mw4q7m3 71 35 cells cell NNS cord-323404-3mw4q7m3 71 36 , , , cord-323404-3mw4q7m3 71 37 whereas whereas IN cord-323404-3mw4q7m3 71 38 vesicular vesicular JJ cord-323404-3mw4q7m3 71 39 stomatitis stomatitis NN cord-323404-3mw4q7m3 71 40 virus virus NN cord-323404-3mw4q7m3 71 41 ( ( -LRB- cord-323404-3mw4q7m3 71 42 VSV VSV NNP cord-323404-3mw4q7m3 71 43 ) ) -RRB- cord-323404-3mw4q7m3 71 44 , , , cord-323404-3mw4q7m3 71 45 which which WDT cord-323404-3mw4q7m3 71 46 is be VBZ cord-323404-3mw4q7m3 71 47 also also RB cord-323404-3mw4q7m3 71 48 enveloped envelop VBN cord-323404-3mw4q7m3 71 49 , , , cord-323404-3mw4q7m3 71 50 is be VBZ cord-323404-3mw4q7m3 71 51 endocytosed endocytose VBN cord-323404-3mw4q7m3 71 52 basolaterally basolaterally RB cord-323404-3mw4q7m3 71 53 2 2 CD cord-323404-3mw4q7m3 71 54 . . . cord-323404-3mw4q7m3 72 1 For for IN cord-323404-3mw4q7m3 72 2 all all DT cord-323404-3mw4q7m3 72 3 of of IN cord-323404-3mw4q7m3 72 4 these these DT cord-323404-3mw4q7m3 72 5 viruses virus NNS cord-323404-3mw4q7m3 72 6 , , , cord-323404-3mw4q7m3 72 7 however however RB cord-323404-3mw4q7m3 72 8 , , , cord-323404-3mw4q7m3 72 9 access access VBP cord-323404-3mw4q7m3 72 10 to to IN cord-323404-3mw4q7m3 72 11 the the DT cord-323404-3mw4q7m3 72 12 cytosol cytosol NN cord-323404-3mw4q7m3 72 13 from from IN cord-323404-3mw4q7m3 72 14 the the DT cord-323404-3mw4q7m3 72 15 endosome endosome NN cord-323404-3mw4q7m3 72 16 is be VBZ cord-323404-3mw4q7m3 72 17 pH pH NNP cord-323404-3mw4q7m3 72 18 dependent dependent JJ cord-323404-3mw4q7m3 72 19 . . . cord-323404-3mw4q7m3 73 1 Other other JJ cord-323404-3mw4q7m3 73 2 viruses virus NNS cord-323404-3mw4q7m3 73 3 can can MD cord-323404-3mw4q7m3 73 4 enter enter VB cord-323404-3mw4q7m3 73 5 by by IN cord-323404-3mw4q7m3 73 6 endocytosis endocytosis NN cord-323404-3mw4q7m3 73 7 at at IN cord-323404-3mw4q7m3 73 8 either either DT cord-323404-3mw4q7m3 73 9 of of IN cord-323404-3mw4q7m3 73 10 the the DT cord-323404-3mw4q7m3 73 11 poles pole NNS cord-323404-3mw4q7m3 73 12 in in IN cord-323404-3mw4q7m3 73 13 epithelial epithelial JJ cord-323404-3mw4q7m3 73 14 cell cell NN cord-323404-3mw4q7m3 73 15 lines line NNS cord-323404-3mw4q7m3 73 16 23 23 CD cord-323404-3mw4q7m3 73 17 , , , cord-323404-3mw4q7m3 73 18 but but CC cord-323404-3mw4q7m3 73 19 each each DT cord-323404-3mw4q7m3 73 20 route route NN cord-323404-3mw4q7m3 73 21 results result VBZ cord-323404-3mw4q7m3 73 22 Most Most JJS cord-323404-3mw4q7m3 73 23 viruses virus NNS cord-323404-3mw4q7m3 73 24 contain contain VBP cord-323404-3mw4q7m3 73 25 two two CD cord-323404-3mw4q7m3 73 26 or or CC cord-323404-3mw4q7m3 73 27 three three CD cord-323404-3mw4q7m3 73 28 elements element NNS cord-323404-3mw4q7m3 73 29 : : : cord-323404-3mw4q7m3 73 30 the the DT cord-323404-3mw4q7m3 73 31 genome genome NN cord-323404-3mw4q7m3 73 32 , , , cord-323404-3mw4q7m3 73 33 in in IN cord-323404-3mw4q7m3 73 34 the the DT cord-323404-3mw4q7m3 73 35 form form NN cord-323404-3mw4q7m3 73 36 of of IN cord-323404-3mw4q7m3 73 37 single single RB cord-323404-3mw4q7m3 73 38 - - HYPH cord-323404-3mw4q7m3 73 39 stranded stranded JJ cord-323404-3mw4q7m3 73 40 ( ( -LRB- cord-323404-3mw4q7m3 73 41 ss ss NNP cord-323404-3mw4q7m3 73 42 ) ) -RRB- cord-323404-3mw4q7m3 73 43 or or CC cord-323404-3mw4q7m3 73 44 double double RB cord-323404-3mw4q7m3 73 45 - - HYPH cord-323404-3mw4q7m3 73 46 stranded stranded JJ cord-323404-3mw4q7m3 73 47 ( ( -LRB- cord-323404-3mw4q7m3 73 48 ds ds NNP cord-323404-3mw4q7m3 73 49 ) ) -RRB- cord-323404-3mw4q7m3 73 50 DNA DNA NNP cord-323404-3mw4q7m3 73 51 or or CC cord-323404-3mw4q7m3 73 52 RNA RNA NNP cord-323404-3mw4q7m3 73 53 ; ; : cord-323404-3mw4q7m3 73 54 the the DT cord-323404-3mw4q7m3 73 55 capsid capsid NN cord-323404-3mw4q7m3 73 56 , , , cord-323404-3mw4q7m3 73 57 which which WDT cord-323404-3mw4q7m3 73 58 consists consist VBZ cord-323404-3mw4q7m3 73 59 of of IN cord-323404-3mw4q7m3 73 60 viral viral JJ cord-323404-3mw4q7m3 73 61 proteins protein NNS cord-323404-3mw4q7m3 73 62 ; ; : cord-323404-3mw4q7m3 73 63 and and CC cord-323404-3mw4q7m3 73 64 , , , cord-323404-3mw4q7m3 73 65 possibly possibly RB cord-323404-3mw4q7m3 73 66 , , , cord-323404-3mw4q7m3 73 67 an an DT cord-323404-3mw4q7m3 73 68 envelope envelope NN cord-323404-3mw4q7m3 73 69 , , , cord-323404-3mw4q7m3 73 70 which which WDT cord-323404-3mw4q7m3 73 71 originates originate VBZ cord-323404-3mw4q7m3 73 72 from from IN cord-323404-3mw4q7m3 73 73 the the DT cord-323404-3mw4q7m3 73 74 host host NN cord-323404-3mw4q7m3 73 75 cell cell NN cord-323404-3mw4q7m3 73 76 and and CC cord-323404-3mw4q7m3 73 77 consists consist VBZ cord-323404-3mw4q7m3 73 78 of of IN cord-323404-3mw4q7m3 73 79 host host NN cord-323404-3mw4q7m3 73 80 - - HYPH cord-323404-3mw4q7m3 73 81 cell cell NN cord-323404-3mw4q7m3 73 82 lipids lipid NNS cord-323404-3mw4q7m3 73 83 that that WDT cord-323404-3mw4q7m3 73 84 are be VBP cord-323404-3mw4q7m3 73 85 organized organize VBN cord-323404-3mw4q7m3 73 86 as as IN cord-323404-3mw4q7m3 73 87 a a DT cord-323404-3mw4q7m3 73 88 bilayer bilayer NN cord-323404-3mw4q7m3 73 89 . . . cord-323404-3mw4q7m3 74 1 Viral viral JJ cord-323404-3mw4q7m3 74 2 - - HYPH cord-323404-3mw4q7m3 74 3 envelope envelope NN cord-323404-3mw4q7m3 74 4 glycoproteins glycoprotein NNS cord-323404-3mw4q7m3 74 5 as as RB cord-323404-3mw4q7m3 74 6 well well RB cord-323404-3mw4q7m3 74 7 as as IN cord-323404-3mw4q7m3 74 8 , , , cord-323404-3mw4q7m3 74 9 in in IN cord-323404-3mw4q7m3 74 10 some some DT cord-323404-3mw4q7m3 74 11 cases case NNS cord-323404-3mw4q7m3 74 12 , , , cord-323404-3mw4q7m3 74 13 selected select VBN cord-323404-3mw4q7m3 74 14 host host NN cord-323404-3mw4q7m3 74 15 - - HYPH cord-323404-3mw4q7m3 74 16 cell cell NN cord-323404-3mw4q7m3 74 17 proteins protein NNS cord-323404-3mw4q7m3 74 18 can can MD cord-323404-3mw4q7m3 74 19 be be VB cord-323404-3mw4q7m3 74 20 recruited recruit VBN cord-323404-3mw4q7m3 74 21 to to IN cord-323404-3mw4q7m3 74 22 the the DT cord-323404-3mw4q7m3 74 23 envelope envelope NN cord-323404-3mw4q7m3 74 24 . . . cord-323404-3mw4q7m3 75 1 ' ' `` cord-323404-3mw4q7m3 75 2 Naked naked JJ cord-323404-3mw4q7m3 75 3 ' ' POS cord-323404-3mw4q7m3 75 4 viruses virus NNS cord-323404-3mw4q7m3 75 5 contain contain VBP cord-323404-3mw4q7m3 75 6 only only RB cord-323404-3mw4q7m3 75 7 the the DT cord-323404-3mw4q7m3 75 8 genetic genetic JJ cord-323404-3mw4q7m3 75 9 material material NN cord-323404-3mw4q7m3 75 10 surrounded surround VBN cord-323404-3mw4q7m3 75 11 by by IN cord-323404-3mw4q7m3 75 12 the the DT cord-323404-3mw4q7m3 75 13 capsid capsid NN cord-323404-3mw4q7m3 75 14 . . . cord-323404-3mw4q7m3 76 1 By by IN cord-323404-3mw4q7m3 76 2 contrast contrast NN cord-323404-3mw4q7m3 76 3 , , , cord-323404-3mw4q7m3 76 4 in in IN cord-323404-3mw4q7m3 76 5 ' ' `` cord-323404-3mw4q7m3 76 6 enveloped envelop VBN cord-323404-3mw4q7m3 76 7 ' ' '' cord-323404-3mw4q7m3 76 8 viruses virus NNS cord-323404-3mw4q7m3 76 9 , , , cord-323404-3mw4q7m3 76 10 the the DT cord-323404-3mw4q7m3 76 11 genome genome NN cord-323404-3mw4q7m3 76 12 is be VBZ cord-323404-3mw4q7m3 76 13 surrounded surround VBN cord-323404-3mw4q7m3 76 14 by by IN cord-323404-3mw4q7m3 76 15 a a DT cord-323404-3mw4q7m3 76 16 capsid capsid NN cord-323404-3mw4q7m3 76 17 and and CC cord-323404-3mw4q7m3 76 18 is be VBZ cord-323404-3mw4q7m3 76 19 protected protect VBN cord-323404-3mw4q7m3 76 20 further far RBR cord-323404-3mw4q7m3 76 21 by by IN cord-323404-3mw4q7m3 76 22 the the DT cord-323404-3mw4q7m3 76 23 viral viral JJ cord-323404-3mw4q7m3 76 24 envelope envelope NN cord-323404-3mw4q7m3 76 25 . . . cord-323404-3mw4q7m3 77 1 [ [ -LRB- cord-323404-3mw4q7m3 77 2 24 24 CD cord-323404-3mw4q7m3 77 3 ] ] -RRB- cord-323404-3mw4q7m3 77 4 [ [ -LRB- cord-323404-3mw4q7m3 77 5 25 25 CD cord-323404-3mw4q7m3 77 6 ] ] -RRB- cord-323404-3mw4q7m3 77 7 [ [ -LRB- cord-323404-3mw4q7m3 77 8 26 26 CD cord-323404-3mw4q7m3 77 9 ] ] -RRB- cord-323404-3mw4q7m3 77 10 at at IN cord-323404-3mw4q7m3 77 11 either either DT cord-323404-3mw4q7m3 77 12 one one CD cord-323404-3mw4q7m3 77 13 of of IN cord-323404-3mw4q7m3 77 14 the the DT cord-323404-3mw4q7m3 77 15 poles pole NNS cord-323404-3mw4q7m3 77 16 followed follow VBN cord-323404-3mw4q7m3 77 17 by by IN cord-323404-3mw4q7m3 77 18 a a DT cord-323404-3mw4q7m3 77 19 pH ph JJ cord-323404-3mw4q7m3 77 20 - - JJ cord-323404-3mw4q7m3 77 21 independent independent JJ cord-323404-3mw4q7m3 77 22 translocation translocation NN cord-323404-3mw4q7m3 77 23 into into IN cord-323404-3mw4q7m3 77 24 the the DT cord-323404-3mw4q7m3 77 25 cytoplasm cytoplasm NN cord-323404-3mw4q7m3 77 26 . . . cord-323404-3mw4q7m3 78 1 The the DT cord-323404-3mw4q7m3 78 2 outcome outcome NN cord-323404-3mw4q7m3 78 3 is be VBZ cord-323404-3mw4q7m3 78 4 either either CC cord-323404-3mw4q7m3 78 5 efficient efficient JJ cord-323404-3mw4q7m3 78 6 viral viral JJ cord-323404-3mw4q7m3 78 7 replication replication NN cord-323404-3mw4q7m3 78 8 followed follow VBN cord-323404-3mw4q7m3 78 9 by by IN cord-323404-3mw4q7m3 78 10 host host NN cord-323404-3mw4q7m3 78 11 - - HYPH cord-323404-3mw4q7m3 78 12 cell cell NN cord-323404-3mw4q7m3 78 13 lysis lysis NN cord-323404-3mw4q7m3 78 14 , , , cord-323404-3mw4q7m3 78 15 or or CC cord-323404-3mw4q7m3 78 16 , , , cord-323404-3mw4q7m3 78 17 alternatively alternatively RB cord-323404-3mw4q7m3 78 18 , , , cord-323404-3mw4q7m3 78 19 latent latent JJ cord-323404-3mw4q7m3 78 20 infection infection NN cord-323404-3mw4q7m3 78 21 . . . cord-323404-3mw4q7m3 79 1 In in IN cord-323404-3mw4q7m3 79 2 the the DT cord-323404-3mw4q7m3 79 3 latter latter JJ cord-323404-3mw4q7m3 79 4 case case NN cord-323404-3mw4q7m3 79 5 , , , cord-323404-3mw4q7m3 79 6 reactivation reactivation NN cord-323404-3mw4q7m3 79 7 of of IN cord-323404-3mw4q7m3 79 8 the the DT cord-323404-3mw4q7m3 79 9 latent latent JJ cord-323404-3mw4q7m3 79 10 viral viral JJ cord-323404-3mw4q7m3 79 11 genome genome NN cord-323404-3mw4q7m3 79 12 might may MD cord-323404-3mw4q7m3 79 13 then then RB cord-323404-3mw4q7m3 79 14 occur occur VB cord-323404-3mw4q7m3 79 15 , , , cord-323404-3mw4q7m3 79 16 and and CC cord-323404-3mw4q7m3 79 17 lead lead VB cord-323404-3mw4q7m3 79 18 to to IN cord-323404-3mw4q7m3 79 19 the the DT cord-323404-3mw4q7m3 79 20 infection infection NN cord-323404-3mw4q7m3 79 21 of of IN cord-323404-3mw4q7m3 79 22 nearby nearby JJ cord-323404-3mw4q7m3 79 23 sensory sensory JJ cord-323404-3mw4q7m3 79 24 neurons neuron NNS cord-323404-3mw4q7m3 79 25 and and CC cord-323404-3mw4q7m3 79 26 the the DT cord-323404-3mw4q7m3 79 27 release release NN cord-323404-3mw4q7m3 79 28 of of IN cord-323404-3mw4q7m3 79 29 new new JJ cord-323404-3mw4q7m3 79 30 virions virion NNS cord-323404-3mw4q7m3 79 31 . . . cord-323404-3mw4q7m3 80 1 These these DT cord-323404-3mw4q7m3 80 2 virions virion NNS cord-323404-3mw4q7m3 80 3 can can MD cord-323404-3mw4q7m3 80 4 then then RB cord-323404-3mw4q7m3 80 5 re re VB cord-323404-3mw4q7m3 80 6 - - VB cord-323404-3mw4q7m3 80 7 enter enter VB cord-323404-3mw4q7m3 80 8 epithelial epithelial JJ cord-323404-3mw4q7m3 80 9 cells cell NNS cord-323404-3mw4q7m3 80 10 -but -but : cord-323404-3mw4q7m3 80 11 now now RB cord-323404-3mw4q7m3 80 12 in in IN cord-323404-3mw4q7m3 80 13 an an DT cord-323404-3mw4q7m3 80 14 highly highly RB cord-323404-3mw4q7m3 80 15 polarized polarized JJ cord-323404-3mw4q7m3 80 16 manner manner NN cord-323404-3mw4q7m3 81 1 -by -by . cord-323404-3mw4q7m3 82 1 fusion fusion NN cord-323404-3mw4q7m3 82 2 at at IN cord-323404-3mw4q7m3 82 3 the the DT cord-323404-3mw4q7m3 82 4 basolateral basolateral JJ cord-323404-3mw4q7m3 82 5 pole pole NN cord-323404-3mw4q7m3 82 6 27 27 CD cord-323404-3mw4q7m3 82 7 . . . cord-323404-3mw4q7m3 83 1 Naked naked JJ cord-323404-3mw4q7m3 83 2 adenoassociated adenoassociate VBN cord-323404-3mw4q7m3 83 3 virus virus NN cord-323404-3mw4q7m3 84 1 ( ( -LRB- cord-323404-3mw4q7m3 84 2 AAV)-2 aav)-2 NN cord-323404-3mw4q7m3 84 3 enters enter VBZ cord-323404-3mw4q7m3 84 4 airway airway NN cord-323404-3mw4q7m3 84 5 epithelial epithelial JJ cord-323404-3mw4q7m3 84 6 cells cell NNS cord-323404-3mw4q7m3 84 7 essentially essentially RB cord-323404-3mw4q7m3 84 8 basolaterally basolaterally RB cord-323404-3mw4q7m3 84 9 by by IN cord-323404-3mw4q7m3 84 10 receptor receptor NN cord-323404-3mw4q7m3 84 11 - - HYPH cord-323404-3mw4q7m3 84 12 mediated mediate VBN cord-323404-3mw4q7m3 84 13 endocytosis endocytosis NN cord-323404-3mw4q7m3 84 14 28 28 CD cord-323404-3mw4q7m3 84 15 . . . cord-323404-3mw4q7m3 85 1 Its -PRON- PRP$ cord-323404-3mw4q7m3 85 2 single single JJ cord-323404-3mw4q7m3 85 3 - - HYPH cord-323404-3mw4q7m3 85 4 stranded stranded JJ cord-323404-3mw4q7m3 85 5 ( ( -LRB- cord-323404-3mw4q7m3 85 6 ss)DNA ss)DNA NNP cord-323404-3mw4q7m3 85 7 is be VBZ cord-323404-3mw4q7m3 85 8 then then RB cord-323404-3mw4q7m3 85 9 converted convert VBN cord-323404-3mw4q7m3 85 10 to to IN cord-323404-3mw4q7m3 85 11 a a DT cord-323404-3mw4q7m3 85 12 circular circular JJ cord-323404-3mw4q7m3 85 13 genome genome NN cord-323404-3mw4q7m3 85 14 , , , cord-323404-3mw4q7m3 85 15 and and CC cord-323404-3mw4q7m3 85 16 its -PRON- PRP$ cord-323404-3mw4q7m3 85 17 polarity polarity NN cord-323404-3mw4q7m3 85 18 of of IN cord-323404-3mw4q7m3 85 19 entry entry NN cord-323404-3mw4q7m3 85 20 is be VBZ cord-323404-3mw4q7m3 85 21 reinforced reinforce VBN cord-323404-3mw4q7m3 85 22 by by IN cord-323404-3mw4q7m3 85 23 a a DT cord-323404-3mw4q7m3 85 24 post post JJ cord-323404-3mw4q7m3 85 25 - - JJ cord-323404-3mw4q7m3 85 26 endocytic endocytic JJ cord-323404-3mw4q7m3 85 27 barrier barrier NN cord-323404-3mw4q7m3 85 28 . . . cord-323404-3mw4q7m3 86 1 By by IN cord-323404-3mw4q7m3 86 2 contrast contrast NN cord-323404-3mw4q7m3 86 3 , , , cord-323404-3mw4q7m3 86 4 AAV-2 AAV-2 NNP cord-323404-3mw4q7m3 86 5 that that WDT cord-323404-3mw4q7m3 86 6 enters enter VBZ cord-323404-3mw4q7m3 86 7 at at IN cord-323404-3mw4q7m3 86 8 the the DT cord-323404-3mw4q7m3 86 9 apical apical JJ cord-323404-3mw4q7m3 86 10 pole pole NN cord-323404-3mw4q7m3 86 11 by by IN cord-323404-3mw4q7m3 86 12 a a DT cord-323404-3mw4q7m3 86 13 receptor receptor NN cord-323404-3mw4q7m3 86 14 - - HYPH cord-323404-3mw4q7m3 86 15 independent independent JJ cord-323404-3mw4q7m3 86 16 mechanism mechanism NN cord-323404-3mw4q7m3 86 17 gives give VBZ cord-323404-3mw4q7m3 86 18 rise rise NN cord-323404-3mw4q7m3 86 19 to to IN cord-323404-3mw4q7m3 86 20 persistent persistent JJ cord-323404-3mw4q7m3 86 21 ssDNA ssdna NN cord-323404-3mw4q7m3 86 22 that that WDT cord-323404-3mw4q7m3 86 23 is be VBZ cord-323404-3mw4q7m3 86 24 arrested arrest VBN cord-323404-3mw4q7m3 86 25 in in IN cord-323404-3mw4q7m3 86 26 a a DT cord-323404-3mw4q7m3 86 27 transcriptionally transcriptionally RB cord-323404-3mw4q7m3 86 28 inactive inactive JJ cord-323404-3mw4q7m3 86 29 form form NN cord-323404-3mw4q7m3 86 30 . . . cord-323404-3mw4q7m3 87 1 The the DT cord-323404-3mw4q7m3 87 2 ubiquitin ubiquitin NN cord-323404-3mw4q7m3 87 3 - - HYPH cord-323404-3mw4q7m3 87 4 proteasome proteasome VBN cord-323404-3mw4q7m3 87 5 pathway pathway NN cord-323404-3mw4q7m3 87 6 , , , cord-323404-3mw4q7m3 87 7 which which WDT cord-323404-3mw4q7m3 87 8 is be VBZ cord-323404-3mw4q7m3 87 9 involved involve VBN cord-323404-3mw4q7m3 87 10 in in IN cord-323404-3mw4q7m3 87 11 the the DT cord-323404-3mw4q7m3 87 12 regulation regulation NN cord-323404-3mw4q7m3 87 13 of of IN cord-323404-3mw4q7m3 87 14 endocytosis endocytosis NN cord-323404-3mw4q7m3 87 15 29 29 CD cord-323404-3mw4q7m3 87 16 , , , cord-323404-3mw4q7m3 87 17 is be VBZ cord-323404-3mw4q7m3 87 18 instrumental instrumental JJ cord-323404-3mw4q7m3 87 19 in in IN cord-323404-3mw4q7m3 87 20 this this DT cord-323404-3mw4q7m3 87 21 arrest arrest NN cord-323404-3mw4q7m3 87 22 30 30 CD cord-323404-3mw4q7m3 87 23 . . . cord-323404-3mw4q7m3 88 1 In in IN cord-323404-3mw4q7m3 88 2 pluristratified pluristratified JJ cord-323404-3mw4q7m3 88 3 epithelia epithelium NNS cord-323404-3mw4q7m3 88 4 or or CC cord-323404-3mw4q7m3 88 5 immature immature JJ cord-323404-3mw4q7m3 88 6 gastrointestinal gastrointestinal JJ cord-323404-3mw4q7m3 88 7 cells cell NNS cord-323404-3mw4q7m3 88 8 , , , cord-323404-3mw4q7m3 88 9 which which WDT cord-323404-3mw4q7m3 88 10 lack lack VBP cord-323404-3mw4q7m3 88 11 TIGHT tight JJ cord-323404-3mw4q7m3 88 12 JUNCTIONS junction NNS cord-323404-3mw4q7m3 88 13 , , , cord-323404-3mw4q7m3 88 14 viral viral JJ cord-323404-3mw4q7m3 88 15 entry entry NN cord-323404-3mw4q7m3 88 16 is be VBZ cord-323404-3mw4q7m3 88 17 not not RB cord-323404-3mw4q7m3 88 18 polarized polarized JJ cord-323404-3mw4q7m3 88 19 . . . cord-323404-3mw4q7m3 89 1 Instead instead RB cord-323404-3mw4q7m3 89 2 , , , cord-323404-3mw4q7m3 89 3 the the DT cord-323404-3mw4q7m3 89 4 viruses virus NNS cord-323404-3mw4q7m3 89 5 make make VBP cord-323404-3mw4q7m3 89 6 use use NN cord-323404-3mw4q7m3 89 7 of of IN cord-323404-3mw4q7m3 89 8 various various JJ cord-323404-3mw4q7m3 89 9 endocytic endocytic JJ cord-323404-3mw4q7m3 89 10 pathways pathway NNS cord-323404-3mw4q7m3 89 11 ( ( -LRB- cord-323404-3mw4q7m3 89 12 BOX BOX NNP cord-323404-3mw4q7m3 89 13 1 1 CD cord-323404-3mw4q7m3 89 14 ) ) -RRB- cord-323404-3mw4q7m3 89 15 . . . cord-323404-3mw4q7m3 90 1 Filovirus Filovirus NNP cord-323404-3mw4q7m3 90 2 , , , cord-323404-3mw4q7m3 90 3 influenza influenza NN cord-323404-3mw4q7m3 90 4 virus virus NN cord-323404-3mw4q7m3 90 5 , , , cord-323404-3mw4q7m3 90 6 simian simian JJ cord-323404-3mw4q7m3 90 7 virus virus NN cord-323404-3mw4q7m3 90 8 40 40 CD cord-323404-3mw4q7m3 91 1 ( ( -LRB- cord-323404-3mw4q7m3 91 2 SV40 SV40 NNP cord-323404-3mw4q7m3 91 3 ) ) -RRB- cord-323404-3mw4q7m3 91 4 and and CC cord-323404-3mw4q7m3 91 5 measles measles NN cord-323404-3mw4q7m3 91 6 virus virus NN cord-323404-3mw4q7m3 91 7 are be VBP cord-323404-3mw4q7m3 91 8 endocytosed endocytose VBN cord-323404-3mw4q7m3 91 9 after after IN cord-323404-3mw4q7m3 91 10 clustering cluster VBG cord-323404-3mw4q7m3 91 11 in in IN cord-323404-3mw4q7m3 91 12 transient transient JJ cord-323404-3mw4q7m3 91 13 raft raft NN cord-323404-3mw4q7m3 91 14 membrane membrane NN cord-323404-3mw4q7m3 91 15 microdomains microdomain NNS cord-323404-3mw4q7m3 91 16 [ [ -LRB- cord-323404-3mw4q7m3 91 17 31 31 CD cord-323404-3mw4q7m3 91 18 ] ] -RRB- cord-323404-3mw4q7m3 92 1 [ [ -LRB- cord-323404-3mw4q7m3 92 2 32 32 CD cord-323404-3mw4q7m3 92 3 ] ] -RRB- cord-323404-3mw4q7m3 92 4 [ [ -LRB- cord-323404-3mw4q7m3 92 5 33 33 CD cord-323404-3mw4q7m3 92 6 ] ] -RRB- cord-323404-3mw4q7m3 92 7 [ [ -LRB- cord-323404-3mw4q7m3 92 8 34 34 CD cord-323404-3mw4q7m3 92 9 ] ] -RRB- cord-323404-3mw4q7m3 92 10 [ [ -LRB- cord-323404-3mw4q7m3 92 11 35 35 CD cord-323404-3mw4q7m3 92 12 ] ] -RRB- cord-323404-3mw4q7m3 92 13 . . . cord-323404-3mw4q7m3 93 1 Some some DT cord-323404-3mw4q7m3 93 2 enveloped envelop VBN cord-323404-3mw4q7m3 93 3 viruses virus NNS cord-323404-3mw4q7m3 93 4 , , , cord-323404-3mw4q7m3 93 5 such such JJ cord-323404-3mw4q7m3 93 6 as as IN cord-323404-3mw4q7m3 93 7 the the DT cord-323404-3mw4q7m3 93 8 Semliki Semliki NNP cord-323404-3mw4q7m3 93 9 Forest Forest NNP cord-323404-3mw4q7m3 93 10 virus virus NN cord-323404-3mw4q7m3 93 11 ( ( -LRB- cord-323404-3mw4q7m3 93 12 SFV SFV NNP cord-323404-3mw4q7m3 93 13 ) ) -RRB- cord-323404-3mw4q7m3 93 14 and and CC cord-323404-3mw4q7m3 93 15 Sindbis Sindbis NNP cord-323404-3mw4q7m3 93 16 virus virus NN cord-323404-3mw4q7m3 93 17 , , , cord-323404-3mw4q7m3 93 18 as as RB cord-323404-3mw4q7m3 93 19 well well RB cord-323404-3mw4q7m3 93 20 as as IN cord-323404-3mw4q7m3 93 21 some some DT cord-323404-3mw4q7m3 93 22 naked naked JJ cord-323404-3mw4q7m3 93 23 viruses virus NNS cord-323404-3mw4q7m3 93 24 , , , cord-323404-3mw4q7m3 93 25 including include VBG cord-323404-3mw4q7m3 93 26 Jamestown Jamestown NNP cord-323404-3mw4q7m3 93 27 Canyon Canyon NNP cord-323404-3mw4q7m3 93 28 ( ( -LRB- cord-323404-3mw4q7m3 93 29 JC JC NNP cord-323404-3mw4q7m3 93 30 ) ) -RRB- cord-323404-3mw4q7m3 93 31 polyoma polyoma NNP cord-323404-3mw4q7m3 93 32 virus virus NN cord-323404-3mw4q7m3 93 33 , , , cord-323404-3mw4q7m3 93 34 parvovirus parvovirus NN cord-323404-3mw4q7m3 93 35 , , , cord-323404-3mw4q7m3 93 36 adenovirus-2 adenovirus-2 NNP cord-323404-3mw4q7m3 93 37 , , , cord-323404-3mw4q7m3 93 38 two two CD cord-323404-3mw4q7m3 93 39 of of IN cord-323404-3mw4q7m3 93 40 the the DT cord-323404-3mw4q7m3 93 41 picorna picorna NNP cord-323404-3mw4q7m3 93 42 viruses virus NNS cord-323404-3mw4q7m3 93 43 -human -human IN cord-323404-3mw4q7m3 93 44 echovirus-1 echovirus-1 NN cord-323404-3mw4q7m3 93 45 ( ( -LRB- cord-323404-3mw4q7m3 93 46 E-1 E-1 NNP cord-323404-3mw4q7m3 93 47 ) ) -RRB- cord-323404-3mw4q7m3 93 48 and and CC cord-323404-3mw4q7m3 93 49 the the DT cord-323404-3mw4q7m3 93 50 minor minor JJ cord-323404-3mw4q7m3 93 51 group group NN cord-323404-3mw4q7m3 93 52 of of IN cord-323404-3mw4q7m3 93 53 human human JJ cord-323404-3mw4q7m3 93 54 rhinoviruses rhinovirus NNS cord-323404-3mw4q7m3 93 55 ( ( -LRB- cord-323404-3mw4q7m3 93 56 HRV HRV NNP cord-323404-3mw4q7m3 93 57 ) ) -RRB- cord-323404-3mw4q7m3 93 58 -and -and : cord-323404-3mw4q7m3 93 59 foot foot NN cord-323404-3mw4q7m3 93 60 and and CC cord-323404-3mw4q7m3 93 61 mouth mouth NN cord-323404-3mw4q7m3 93 62 disease disease NN cord-323404-3mw4q7m3 93 63 virus virus NN cord-323404-3mw4q7m3 93 64 ( ( -LRB- cord-323404-3mw4q7m3 93 65 FMDV FMDV NNP cord-323404-3mw4q7m3 93 66 ) ) -RRB- cord-323404-3mw4q7m3 93 67 , , . cord-323404-3mw4q7m3 94 1 use use VB cord-323404-3mw4q7m3 94 2 receptor receptor NN cord-323404-3mw4q7m3 94 3 - - HYPH cord-323404-3mw4q7m3 94 4 mediated mediate VBN cord-323404-3mw4q7m3 94 5 endocytosis endocytosis NN cord-323404-3mw4q7m3 94 6 through through IN cord-323404-3mw4q7m3 94 7 the the DT cord-323404-3mw4q7m3 94 8 CLATHRIN CLATHRIN NNP cord-323404-3mw4q7m3 94 9 - - HYPH cord-323404-3mw4q7m3 94 10 COATED COATED NNP cord-323404-3mw4q7m3 94 11 - - HYPH cord-323404-3mw4q7m3 94 12 VESICLE VESICLE NNP cord-323404-3mw4q7m3 94 13 pathway pathway NN cord-323404-3mw4q7m3 94 14 [ [ -LRB- cord-323404-3mw4q7m3 94 15 36 36 CD cord-323404-3mw4q7m3 94 16 ] ] -RRB- cord-323404-3mw4q7m3 95 1 [ [ -LRB- cord-323404-3mw4q7m3 95 2 37 37 CD cord-323404-3mw4q7m3 95 3 ] ] -RRB- cord-323404-3mw4q7m3 95 4 [ [ -LRB- cord-323404-3mw4q7m3 95 5 38 38 CD cord-323404-3mw4q7m3 95 6 ] ] -RRB- cord-323404-3mw4q7m3 96 1 [ [ -LRB- cord-323404-3mw4q7m3 96 2 39 39 CD cord-323404-3mw4q7m3 96 3 ] ] -RRB- cord-323404-3mw4q7m3 96 4 [ [ -LRB- cord-323404-3mw4q7m3 96 5 40 40 CD cord-323404-3mw4q7m3 96 6 ] ] -RRB- cord-323404-3mw4q7m3 96 7 . . . cord-323404-3mw4q7m3 97 1 Once once IN cord-323404-3mw4q7m3 97 2 they -PRON- PRP cord-323404-3mw4q7m3 97 3 are be VBP cord-323404-3mw4q7m3 97 4 in in IN cord-323404-3mw4q7m3 97 5 endosomes endosome NNS cord-323404-3mw4q7m3 97 6 , , , cord-323404-3mw4q7m3 97 7 the the DT cord-323404-3mw4q7m3 97 8 surface surface NN cord-323404-3mw4q7m3 97 9 proteins protein NNS cord-323404-3mw4q7m3 97 10 of of IN cord-323404-3mw4q7m3 97 11 viruses virus NNS cord-323404-3mw4q7m3 97 12 such such JJ cord-323404-3mw4q7m3 97 13 as as IN cord-323404-3mw4q7m3 97 14 influenza influenza NN cord-323404-3mw4q7m3 97 15 , , , cord-323404-3mw4q7m3 97 16 FMDV FMDV NNP cord-323404-3mw4q7m3 97 17 , , , cord-323404-3mw4q7m3 97 18 VSV VSV NNP cord-323404-3mw4q7m3 97 19 , , , cord-323404-3mw4q7m3 97 20 Sindbis Sindbis NNP cord-323404-3mw4q7m3 97 21 virus virus NN cord-323404-3mw4q7m3 97 22 or or CC cord-323404-3mw4q7m3 97 23 SFV sfv NN cord-323404-3mw4q7m3 97 24 undergo undergo VB cord-323404-3mw4q7m3 97 25 a a DT cord-323404-3mw4q7m3 97 26 conformational conformational JJ cord-323404-3mw4q7m3 97 27 change change NN cord-323404-3mw4q7m3 97 28 that that WDT cord-323404-3mw4q7m3 97 29 is be VBZ cord-323404-3mw4q7m3 97 30 dependent dependent JJ cord-323404-3mw4q7m3 97 31 on on IN cord-323404-3mw4q7m3 97 32 a a DT cord-323404-3mw4q7m3 97 33 mildly mildly RB cord-323404-3mw4q7m3 97 34 acidic acidic JJ cord-323404-3mw4q7m3 97 35 pH ph NN cord-323404-3mw4q7m3 97 36 , , , cord-323404-3mw4q7m3 97 37 and and CC cord-323404-3mw4q7m3 97 38 they -PRON- PRP cord-323404-3mw4q7m3 97 39 can can MD cord-323404-3mw4q7m3 97 40 then then RB cord-323404-3mw4q7m3 97 41 disrupt disrupt VB cord-323404-3mw4q7m3 97 42 the the DT cord-323404-3mw4q7m3 97 43 endosomal endosomal NNP cord-323404-3mw4q7m3 97 44 membrane membrane NN cord-323404-3mw4q7m3 97 45 . . . cord-323404-3mw4q7m3 98 1 Alternatively alternatively RB cord-323404-3mw4q7m3 98 2 , , , cord-323404-3mw4q7m3 98 3 other other JJ cord-323404-3mw4q7m3 98 4 viruses virus NNS cord-323404-3mw4q7m3 98 5 , , , cord-323404-3mw4q7m3 98 6 such such JJ cord-323404-3mw4q7m3 98 7 as as IN cord-323404-3mw4q7m3 98 8 the the DT cord-323404-3mw4q7m3 98 9 poliovirus poliovirus NN cord-323404-3mw4q7m3 98 10 18 18 CD cord-323404-3mw4q7m3 98 11 , , , cord-323404-3mw4q7m3 98 12 19 19 CD cord-323404-3mw4q7m3 98 13 and and CC cord-323404-3mw4q7m3 98 14 the the DT cord-323404-3mw4q7m3 98 15 major major JJ cord-323404-3mw4q7m3 98 16 group group NN cord-323404-3mw4q7m3 98 17 of of IN cord-323404-3mw4q7m3 98 18 HRV HRV NNP cord-323404-3mw4q7m3 98 19 41 41 CD cord-323404-3mw4q7m3 98 20 , , , cord-323404-3mw4q7m3 98 21 translocate translocate VBP cord-323404-3mw4q7m3 98 22 from from IN cord-323404-3mw4q7m3 98 23 the the DT cord-323404-3mw4q7m3 98 24 endosome endosome NN cord-323404-3mw4q7m3 98 25 into into IN cord-323404-3mw4q7m3 98 26 the the DT cord-323404-3mw4q7m3 98 27 cell cell NN cord-323404-3mw4q7m3 98 28 cytosol cytosol NN cord-323404-3mw4q7m3 98 29 in in IN cord-323404-3mw4q7m3 98 30 a a DT cord-323404-3mw4q7m3 98 31 pH ph JJ cord-323404-3mw4q7m3 98 32 - - HYPH cord-323404-3mw4q7m3 98 33 insensitive insensitive JJ cord-323404-3mw4q7m3 98 34 manner manner NN cord-323404-3mw4q7m3 98 35 , , , cord-323404-3mw4q7m3 98 36 before before IN cord-323404-3mw4q7m3 98 37 gaining gain VBG cord-323404-3mw4q7m3 98 38 access access NN cord-323404-3mw4q7m3 98 39 to to IN cord-323404-3mw4q7m3 98 40 the the DT cord-323404-3mw4q7m3 98 41 lysosome lysosome NN cord-323404-3mw4q7m3 98 42 -a -a HYPH cord-323404-3mw4q7m3 98 43 compartment compartment NN cord-323404-3mw4q7m3 98 44 that that WDT cord-323404-3mw4q7m3 98 45 is be VBZ cord-323404-3mw4q7m3 98 46 deeper deep JJR cord-323404-3mw4q7m3 98 47 in in IN cord-323404-3mw4q7m3 98 48 the the DT cord-323404-3mw4q7m3 98 49 endocytic endocytic JJ cord-323404-3mw4q7m3 98 50 pathway pathway NN cord-323404-3mw4q7m3 98 51 19 19 CD cord-323404-3mw4q7m3 98 52 , , , cord-323404-3mw4q7m3 98 53 41 41 CD cord-323404-3mw4q7m3 98 54 . . . cord-323404-3mw4q7m3 99 1 A a DT cord-323404-3mw4q7m3 100 1 Ca ca NN cord-323404-3mw4q7m3 100 2 2 2 CD cord-323404-3mw4q7m3 100 3 + + CD cord-323404-3mw4q7m3 101 1 -dependent -dependent JJ cord-323404-3mw4q7m3 101 2 , , , cord-323404-3mw4q7m3 101 3 but but CC cord-323404-3mw4q7m3 101 4 pH ph NN cord-323404-3mw4q7m3 101 5 - - NN cord-323404-3mw4q7m3 101 6 independent independent JJ cord-323404-3mw4q7m3 101 7 , , , cord-323404-3mw4q7m3 101 8 endocytosis endocytosis NN cord-323404-3mw4q7m3 101 9 and and CC cord-323404-3mw4q7m3 101 10 virusuncoating virusuncoating NN cord-323404-3mw4q7m3 101 11 model model NN cord-323404-3mw4q7m3 101 12 has have VBZ cord-323404-3mw4q7m3 101 13 been be VBN cord-323404-3mw4q7m3 101 14 proposed propose VBN cord-323404-3mw4q7m3 101 15 for for IN cord-323404-3mw4q7m3 101 16 the the DT cord-323404-3mw4q7m3 101 17 rotavirus rotavirus JJ cord-323404-3mw4q7m3 101 18 42 42 CD cord-323404-3mw4q7m3 101 19 that that WDT cord-323404-3mw4q7m3 101 20 would would MD cord-323404-3mw4q7m3 101 21 apply apply VB cord-323404-3mw4q7m3 101 22 equally equally RB cord-323404-3mw4q7m3 101 23 to to IN cord-323404-3mw4q7m3 101 24 other other JJ cord-323404-3mw4q7m3 101 25 viruses virus NNS cord-323404-3mw4q7m3 101 26 , , , cord-323404-3mw4q7m3 101 27 whether whether IN cord-323404-3mw4q7m3 101 28 they -PRON- PRP cord-323404-3mw4q7m3 101 29 are be VBP cord-323404-3mw4q7m3 101 30 enveloped envelop VBN cord-323404-3mw4q7m3 101 31 or or CC cord-323404-3mw4q7m3 101 32 naked naked JJ cord-323404-3mw4q7m3 101 33 . . . cord-323404-3mw4q7m3 102 1 The the DT cord-323404-3mw4q7m3 102 2 differences difference NNS cord-323404-3mw4q7m3 102 3 in in IN cord-323404-3mw4q7m3 102 4 the the DT cord-323404-3mw4q7m3 102 5 viral viral JJ cord-323404-3mw4q7m3 102 6 - - HYPH cord-323404-3mw4q7m3 102 7 entry entry NN cord-323404-3mw4q7m3 102 8 pathways pathway NNS cord-323404-3mw4q7m3 102 9 are be VBP cord-323404-3mw4q7m3 102 10 due due JJ cord-323404-3mw4q7m3 102 11 largely largely RB cord-323404-3mw4q7m3 102 12 to to IN cord-323404-3mw4q7m3 102 13 the the DT cord-323404-3mw4q7m3 102 14 nature nature NN cord-323404-3mw4q7m3 102 15 of of IN cord-323404-3mw4q7m3 102 16 the the DT cord-323404-3mw4q7m3 102 17 molecular molecular JJ cord-323404-3mw4q7m3 102 18 interactions interaction NNS cord-323404-3mw4q7m3 102 19 between between IN cord-323404-3mw4q7m3 102 20 the the DT cord-323404-3mw4q7m3 102 21 viral viral JJ cord-323404-3mw4q7m3 102 22 components component NNS cord-323404-3mw4q7m3 102 23 and and CC cord-323404-3mw4q7m3 102 24 target target NN cord-323404-3mw4q7m3 102 25 - - HYPH cord-323404-3mw4q7m3 102 26 cell cell NN cord-323404-3mw4q7m3 102 27 receptors receptor NNS cord-323404-3mw4q7m3 102 28 . . . cord-323404-3mw4q7m3 103 1 Viral viral JJ cord-323404-3mw4q7m3 103 2 pathogenesis pathogenesis NN cord-323404-3mw4q7m3 103 3 arises arise VBZ cord-323404-3mw4q7m3 103 4 from from IN cord-323404-3mw4q7m3 103 5 mechanisms mechanism NNS cord-323404-3mw4q7m3 103 6 that that WDT cord-323404-3mw4q7m3 103 7 have have VBP cord-323404-3mw4q7m3 103 8 been be VBN cord-323404-3mw4q7m3 103 9 developed develop VBN cord-323404-3mw4q7m3 103 10 M M NNP cord-323404-3mw4q7m3 103 11 CELL CELL NNP cord-323404-3mw4q7m3 103 12 ' ' '' cord-323404-3mw4q7m3 103 13 Membranous Membranous NNP cord-323404-3mw4q7m3 103 14 ' ' '' cord-323404-3mw4q7m3 103 15 or or CC cord-323404-3mw4q7m3 103 16 ' ' `` cord-323404-3mw4q7m3 103 17 microfold microfold JJ cord-323404-3mw4q7m3 103 18 ' ' '' cord-323404-3mw4q7m3 103 19 cell cell NN cord-323404-3mw4q7m3 103 20 . . . cord-323404-3mw4q7m3 104 1 This this DT cord-323404-3mw4q7m3 104 2 is be VBZ cord-323404-3mw4q7m3 104 3 a a DT cord-323404-3mw4q7m3 104 4 specialized specialized JJ cord-323404-3mw4q7m3 104 5 epithelial epithelial JJ cord-323404-3mw4q7m3 104 6 cell cell NN cord-323404-3mw4q7m3 104 7 covering cover VBG cord-323404-3mw4q7m3 104 8 the the DT cord-323404-3mw4q7m3 104 9 lymphoid lymphoid JJ cord-323404-3mw4q7m3 104 10 Peyer Peyer NNP cord-323404-3mw4q7m3 104 11 's 's POS cord-323404-3mw4q7m3 104 12 patches patch NNS cord-323404-3mw4q7m3 104 13 in in IN cord-323404-3mw4q7m3 104 14 the the DT cord-323404-3mw4q7m3 104 15 gut gut NN cord-323404-3mw4q7m3 104 16 . . . cord-323404-3mw4q7m3 105 1 M m NN cord-323404-3mw4q7m3 105 2 cells cell NNS cord-323404-3mw4q7m3 105 3 can can MD cord-323404-3mw4q7m3 105 4 internalize internalize VB cord-323404-3mw4q7m3 105 5 macromolecules macromolecule NNS cord-323404-3mw4q7m3 105 6 and and CC cord-323404-3mw4q7m3 105 7 microorganisms microorganism NNS cord-323404-3mw4q7m3 105 8 and and CC cord-323404-3mw4q7m3 105 9 deliver deliver VB cord-323404-3mw4q7m3 105 10 them -PRON- PRP cord-323404-3mw4q7m3 105 11 to to IN cord-323404-3mw4q7m3 105 12 the the DT cord-323404-3mw4q7m3 105 13 underlying underlying JJ cord-323404-3mw4q7m3 105 14 lymphoid lymphoid JJ cord-323404-3mw4q7m3 105 15 tissue tissue NN cord-323404-3mw4q7m3 105 16 . . . cord-323404-3mw4q7m3 106 1 ENDOSOME ENDOSOME NNP cord-323404-3mw4q7m3 106 2 A a DT cord-323404-3mw4q7m3 106 3 membranous membranous JJ cord-323404-3mw4q7m3 106 4 transport transport NN cord-323404-3mw4q7m3 106 5 vesicle vesicle NN cord-323404-3mw4q7m3 106 6 that that WDT cord-323404-3mw4q7m3 106 7 is be VBZ cord-323404-3mw4q7m3 106 8 involved involve VBN cord-323404-3mw4q7m3 106 9 in in IN cord-323404-3mw4q7m3 106 10 endocytosis endocytosis NN cord-323404-3mw4q7m3 106 11 . . . cord-323404-3mw4q7m3 107 1 A a DT cord-323404-3mw4q7m3 107 2 protein protein NN cord-323404-3mw4q7m3 107 3 heterocomplex heterocomplex NN cord-323404-3mw4q7m3 107 4 that that WDT cord-323404-3mw4q7m3 107 5 connects connect VBZ cord-323404-3mw4q7m3 107 6 neighbouring neighbour VBG cord-323404-3mw4q7m3 107 7 simple simple JJ cord-323404-3mw4q7m3 107 8 epithelial epithelial JJ cord-323404-3mw4q7m3 107 9 cells cell NNS cord-323404-3mw4q7m3 107 10 and and CC cord-323404-3mw4q7m3 107 11 controls control VBZ cord-323404-3mw4q7m3 107 12 the the DT cord-323404-3mw4q7m3 107 13 barrier barrier NN cord-323404-3mw4q7m3 107 14 function function NN cord-323404-3mw4q7m3 107 15 of of IN cord-323404-3mw4q7m3 107 16 the the DT cord-323404-3mw4q7m3 107 17 tight tight JJ cord-323404-3mw4q7m3 107 18 mucosal mucosal JJ cord-323404-3mw4q7m3 107 19 surface surface NN cord-323404-3mw4q7m3 107 20 . . . cord-323404-3mw4q7m3 108 1 An an DT cord-323404-3mw4q7m3 108 2 invagination invagination NN cord-323404-3mw4q7m3 108 3 of of IN cord-323404-3mw4q7m3 108 4 the the DT cord-323404-3mw4q7m3 108 5 plasma plasma NN cord-323404-3mw4q7m3 108 6 membrane membrane NN cord-323404-3mw4q7m3 108 7 that that WDT cord-323404-3mw4q7m3 108 8 is be VBZ cord-323404-3mw4q7m3 108 9 surrounded surround VBN cord-323404-3mw4q7m3 108 10 by by IN cord-323404-3mw4q7m3 108 11 clathrin clathrin NNP cord-323404-3mw4q7m3 108 12 , , , cord-323404-3mw4q7m3 108 13 a a DT cord-323404-3mw4q7m3 108 14 cytosolic cytosolic JJ cord-323404-3mw4q7m3 108 15 protein protein NN cord-323404-3mw4q7m3 108 16 that that WDT cord-323404-3mw4q7m3 108 17 is be VBZ cord-323404-3mw4q7m3 108 18 formed form VBN cord-323404-3mw4q7m3 108 19 by by IN cord-323404-3mw4q7m3 108 20 a a DT cord-323404-3mw4q7m3 108 21 triskelion triskelion NN cord-323404-3mw4q7m3 108 22 of of IN cord-323404-3mw4q7m3 108 23 three three CD cord-323404-3mw4q7m3 108 24 heavy heavy JJ cord-323404-3mw4q7m3 108 25 and and CC cord-323404-3mw4q7m3 108 26 three three CD cord-323404-3mw4q7m3 108 27 light light JJ cord-323404-3mw4q7m3 108 28 chains chain NNS cord-323404-3mw4q7m3 108 29 . . . cord-323404-3mw4q7m3 109 1 Triskelions triskelion NNS cord-323404-3mw4q7m3 109 2 assemble assemble VBP cord-323404-3mw4q7m3 109 3 into into IN cord-323404-3mw4q7m3 109 4 a a DT cord-323404-3mw4q7m3 109 5 polyhedral polyhedral JJ cord-323404-3mw4q7m3 109 6 lattice lattice NN cord-323404-3mw4q7m3 109 7 to to TO cord-323404-3mw4q7m3 109 8 form form VB cord-323404-3mw4q7m3 109 9 the the DT cord-323404-3mw4q7m3 109 10 clathrin clathrin NN cord-323404-3mw4q7m3 109 11 coat coat NN cord-323404-3mw4q7m3 109 12 . . . cord-323404-3mw4q7m3 110 1 process process NN cord-323404-3mw4q7m3 110 2 of of IN cord-323404-3mw4q7m3 110 3 viral viral JJ cord-323404-3mw4q7m3 110 4 infection infection NN cord-323404-3mw4q7m3 110 5 is be VBZ cord-323404-3mw4q7m3 110 6 difficult difficult JJ cord-323404-3mw4q7m3 110 7 to to TO cord-323404-3mw4q7m3 110 8 assess assess VB cord-323404-3mw4q7m3 110 9 . . . cord-323404-3mw4q7m3 111 1 Indeed indeed RB cord-323404-3mw4q7m3 111 2 , , , cord-323404-3mw4q7m3 111 3 at at IN cord-323404-3mw4q7m3 111 4 the the DT cord-323404-3mw4q7m3 111 5 molecular molecular JJ cord-323404-3mw4q7m3 111 6 level level NN cord-323404-3mw4q7m3 111 7 , , , cord-323404-3mw4q7m3 111 8 the the DT cord-323404-3mw4q7m3 111 9 kinetics kinetic NNS cord-323404-3mw4q7m3 111 10 of of IN cord-323404-3mw4q7m3 111 11 each each DT cord-323404-3mw4q7m3 111 12 virus virus NN cord-323404-3mw4q7m3 111 13 - - HYPH cord-323404-3mw4q7m3 111 14 host host NN cord-323404-3mw4q7m3 111 15 - - HYPH cord-323404-3mw4q7m3 111 16 cell cell NN cord-323404-3mw4q7m3 111 17 interaction interaction NN cord-323404-3mw4q7m3 111 18 is be VBZ cord-323404-3mw4q7m3 111 19 dependent dependent JJ cord-323404-3mw4q7m3 111 20 on on IN cord-323404-3mw4q7m3 111 21 its -PRON- PRP$ cord-323404-3mw4q7m3 111 22 association association NN cord-323404-3mw4q7m3 111 23 constant constant NN cord-323404-3mw4q7m3 111 24 , , , cord-323404-3mw4q7m3 111 25 the the DT cord-323404-3mw4q7m3 111 26 concentration concentration NN cord-323404-3mw4q7m3 111 27 of of IN cord-323404-3mw4q7m3 111 28 viral viral JJ cord-323404-3mw4q7m3 111 29 ligands ligand NNS cord-323404-3mw4q7m3 111 30 and and CC cord-323404-3mw4q7m3 111 31 of of IN cord-323404-3mw4q7m3 111 32 host host NN cord-323404-3mw4q7m3 111 33 - - HYPH cord-323404-3mw4q7m3 111 34 cell cell NN cord-323404-3mw4q7m3 111 35 receptors receptor NNS cord-323404-3mw4q7m3 111 36 that that WDT cord-323404-3mw4q7m3 111 37 are be VBP cord-323404-3mw4q7m3 111 38 available available JJ cord-323404-3mw4q7m3 111 39 to to TO cord-323404-3mw4q7m3 111 40 interact interact VB cord-323404-3mw4q7m3 111 41 at at IN cord-323404-3mw4q7m3 111 42 any any DT cord-323404-3mw4q7m3 111 43 given give VBN cord-323404-3mw4q7m3 111 44 moment moment NN cord-323404-3mw4q7m3 111 45 , , , cord-323404-3mw4q7m3 111 46 and and CC cord-323404-3mw4q7m3 111 47 the the DT cord-323404-3mw4q7m3 111 48 nature nature NN cord-323404-3mw4q7m3 111 49 of of IN cord-323404-3mw4q7m3 111 50 the the DT cord-323404-3mw4q7m3 111 51 target target NN cord-323404-3mw4q7m3 111 52 cell cell NN cord-323404-3mw4q7m3 111 53 . . . cord-323404-3mw4q7m3 112 1 To to TO cord-323404-3mw4q7m3 112 2 attach attach VB cord-323404-3mw4q7m3 112 3 to to IN cord-323404-3mw4q7m3 112 4 the the DT cord-323404-3mw4q7m3 112 5 surface surface NN cord-323404-3mw4q7m3 112 6 of of IN cord-323404-3mw4q7m3 112 7 the the DT cord-323404-3mw4q7m3 112 8 target target NN cord-323404-3mw4q7m3 112 9 cell cell NN cord-323404-3mw4q7m3 112 10 , , , cord-323404-3mw4q7m3 112 11 an an DT cord-323404-3mw4q7m3 112 12 increasing increase VBG cord-323404-3mw4q7m3 112 13 number number NN cord-323404-3mw4q7m3 112 14 of of IN cord-323404-3mw4q7m3 112 15 enveloped envelop VBN cord-323404-3mw4q7m3 112 16 or or CC cord-323404-3mw4q7m3 112 17 naked naked JJ cord-323404-3mw4q7m3 112 18 viruses virus NNS cord-323404-3mw4q7m3 112 19 have have VBP cord-323404-3mw4q7m3 112 20 been be VBN cord-323404-3mw4q7m3 112 21 described describe VBN cord-323404-3mw4q7m3 112 22 as as IN cord-323404-3mw4q7m3 112 23 acting act VBG cord-323404-3mw4q7m3 112 24 as as IN cord-323404-3mw4q7m3 112 25 lectins lectin NNS cord-323404-3mw4q7m3 112 26 , , , cord-323404-3mw4q7m3 112 27 by by IN cord-323404-3mw4q7m3 112 28 using use VBG cord-323404-3mw4q7m3 112 29 a a DT cord-323404-3mw4q7m3 112 30 peptide peptide NN cord-323404-3mw4q7m3 112 31 of of IN cord-323404-3mw4q7m3 112 32 their -PRON- PRP$ cord-323404-3mw4q7m3 112 33 envelope envelope NN cord-323404-3mw4q7m3 112 34 or or CC cord-323404-3mw4q7m3 112 35 capsid capsid NN cord-323404-3mw4q7m3 112 36 proteins protein NNS cord-323404-3mw4q7m3 112 37 , , , cord-323404-3mw4q7m3 112 38 respectively respectively RB cord-323404-3mw4q7m3 112 39 , , , cord-323404-3mw4q7m3 112 40 that that DT cord-323404-3mw4q7m3 112 41 has have VBZ cord-323404-3mw4q7m3 112 42 a a DT cord-323404-3mw4q7m3 112 43 lectin lectin NN cord-323404-3mw4q7m3 112 44 site site NN cord-323404-3mw4q7m3 112 45 . . . cord-323404-3mw4q7m3 113 1 They -PRON- PRP cord-323404-3mw4q7m3 113 2 compete compete VBP cord-323404-3mw4q7m3 113 3 with with IN cord-323404-3mw4q7m3 113 4 endogenous endogenous JJ cord-323404-3mw4q7m3 113 5 lectins lectin NNS cord-323404-3mw4q7m3 113 6 to to TO cord-323404-3mw4q7m3 113 7 bind bind VB cord-323404-3mw4q7m3 113 8 epithelial epithelial JJ cord-323404-3mw4q7m3 113 9 - - HYPH cord-323404-3mw4q7m3 113 10 cell cell NN cord-323404-3mw4q7m3 113 11 - - HYPH cord-323404-3mw4q7m3 113 12 surface surface NN cord-323404-3mw4q7m3 113 13 carbohydrates carbohydrate NNS cord-323404-3mw4q7m3 113 14 , , , cord-323404-3mw4q7m3 113 15 which which WDT cord-323404-3mw4q7m3 113 16 act act VBP cord-323404-3mw4q7m3 113 17 as as IN cord-323404-3mw4q7m3 113 18 attachment attachment NN cord-323404-3mw4q7m3 113 19 receptors receptor NNS cord-323404-3mw4q7m3 113 20 . . . cord-323404-3mw4q7m3 114 1 Viral viral JJ cord-323404-3mw4q7m3 114 2 surface surface NN cord-323404-3mw4q7m3 114 3 proteins protein NNS cord-323404-3mw4q7m3 114 4 are be VBP cord-323404-3mw4q7m3 114 5 multimeric multimeric JJ cord-323404-3mw4q7m3 114 6 , , , cord-323404-3mw4q7m3 114 7 they -PRON- PRP cord-323404-3mw4q7m3 114 8 have have VBP cord-323404-3mw4q7m3 114 9 several several JJ cord-323404-3mw4q7m3 114 10 lectin lectin NN cord-323404-3mw4q7m3 114 11 sites site NNS cord-323404-3mw4q7m3 114 12 , , , cord-323404-3mw4q7m3 114 13 so so IN cord-323404-3mw4q7m3 114 14 they -PRON- PRP cord-323404-3mw4q7m3 114 15 can can MD cord-323404-3mw4q7m3 114 16 interact interact VB cord-323404-3mw4q7m3 114 17 with with IN cord-323404-3mw4q7m3 114 18 several several JJ cord-323404-3mw4q7m3 114 19 receptor receptor NN cord-323404-3mw4q7m3 114 20 molecules molecule NNS cord-323404-3mw4q7m3 114 21 at at IN cord-323404-3mw4q7m3 114 22 a a DT cord-323404-3mw4q7m3 114 23 time time NN cord-323404-3mw4q7m3 114 24 at at IN cord-323404-3mw4q7m3 114 25 the the DT cord-323404-3mw4q7m3 114 26 host host NN cord-323404-3mw4q7m3 114 27 - - HYPH cord-323404-3mw4q7m3 114 28 cell cell NN cord-323404-3mw4q7m3 114 29 surface surface NN cord-323404-3mw4q7m3 114 30 . . . cord-323404-3mw4q7m3 115 1 Such such JJ cord-323404-3mw4q7m3 115 2 clusters cluster NNS cord-323404-3mw4q7m3 115 3 of of IN cord-323404-3mw4q7m3 115 4 lectin lectin NN cord-323404-3mw4q7m3 115 5 sites site NNS cord-323404-3mw4q7m3 115 6 have have VBP cord-323404-3mw4q7m3 115 7 a a DT cord-323404-3mw4q7m3 115 8 much much RB cord-323404-3mw4q7m3 115 9 higher high JJR cord-323404-3mw4q7m3 115 10 affinity affinity NN cord-323404-3mw4q7m3 115 11 for for IN cord-323404-3mw4q7m3 115 12 oligosaccharides oligosaccharide NNS cord-323404-3mw4q7m3 115 13 than than IN cord-323404-3mw4q7m3 115 14 their -PRON- PRP$ cord-323404-3mw4q7m3 115 15 monomeric monomeric JJ cord-323404-3mw4q7m3 115 16 counterparts counterpart NNS cord-323404-3mw4q7m3 115 17 44 44 CD cord-323404-3mw4q7m3 115 18 . . . cord-323404-3mw4q7m3 116 1 This this DT cord-323404-3mw4q7m3 116 2 multimeric multimeric JJ cord-323404-3mw4q7m3 116 3 interaction interaction NN cord-323404-3mw4q7m3 116 4 interferes interfere VBZ cord-323404-3mw4q7m3 116 5 with with IN cord-323404-3mw4q7m3 116 6 lipid lipid NN cord-323404-3mw4q7m3 116 7 organization organization NN cord-323404-3mw4q7m3 116 8 and and CC cord-323404-3mw4q7m3 116 9 dynamics dynamic NNS cord-323404-3mw4q7m3 116 10 , , , cord-323404-3mw4q7m3 116 11 and and CC cord-323404-3mw4q7m3 116 12 stabilizes stabilize VBZ cord-323404-3mw4q7m3 116 13 raft raft NN cord-323404-3mw4q7m3 116 14 microdomains microdomain NNS cord-323404-3mw4q7m3 116 15 at at IN cord-323404-3mw4q7m3 116 16 the the DT cord-323404-3mw4q7m3 116 17 epithelial epithelial JJ cord-323404-3mw4q7m3 116 18 - - HYPH cord-323404-3mw4q7m3 116 19 cell cell NN cord-323404-3mw4q7m3 116 20 membrane membrane NN cord-323404-3mw4q7m3 116 21 . . . cord-323404-3mw4q7m3 117 1 The the DT cord-323404-3mw4q7m3 117 2 lipids lipid NNS cord-323404-3mw4q7m3 117 3 in in IN cord-323404-3mw4q7m3 117 4 these these DT cord-323404-3mw4q7m3 117 5 domains domain NNS cord-323404-3mw4q7m3 117 6 differ differ VBP cord-323404-3mw4q7m3 117 7 from from IN cord-323404-3mw4q7m3 117 8 other other JJ cord-323404-3mw4q7m3 117 9 membrane membrane NN cord-323404-3mw4q7m3 117 10 lipids lipid NNS cord-323404-3mw4q7m3 117 11 in in IN cord-323404-3mw4q7m3 117 12 their -PRON- PRP$ cord-323404-3mw4q7m3 117 13 lateral lateral JJ cord-323404-3mw4q7m3 117 14 diffusion diffusion NN cord-323404-3mw4q7m3 117 15 in in IN cord-323404-3mw4q7m3 117 16 the the DT cord-323404-3mw4q7m3 117 17 membrane membrane NN cord-323404-3mw4q7m3 117 18 , , , cord-323404-3mw4q7m3 117 19 and and CC cord-323404-3mw4q7m3 117 20 they -PRON- PRP cord-323404-3mw4q7m3 117 21 can can MD cord-323404-3mw4q7m3 117 22 be be VB cord-323404-3mw4q7m3 117 23 separated separate VBN cord-323404-3mw4q7m3 117 24 in in IN cord-323404-3mw4q7m3 117 25 vitro vitro FW cord-323404-3mw4q7m3 117 26 , , , cord-323404-3mw4q7m3 117 27 owing owe VBG cord-323404-3mw4q7m3 117 28 to to IN cord-323404-3mw4q7m3 117 29 their -PRON- PRP$ cord-323404-3mw4q7m3 117 30 insolubility insolubility NN cord-323404-3mw4q7m3 117 31 in in IN cord-323404-3mw4q7m3 117 32 detergent detergent NN cord-323404-3mw4q7m3 117 33 . . . cord-323404-3mw4q7m3 118 1 The the DT cord-323404-3mw4q7m3 118 2 rafts raft NNS cord-323404-3mw4q7m3 118 3 are be VBP cord-323404-3mw4q7m3 118 4 small small JJ cord-323404-3mw4q7m3 118 5 , , , cord-323404-3mw4q7m3 118 6 mobile mobile JJ cord-323404-3mw4q7m3 118 7 , , , cord-323404-3mw4q7m3 118 8 unstable unstable JJ cord-323404-3mw4q7m3 118 9 and and CC cord-323404-3mw4q7m3 118 10 they -PRON- PRP cord-323404-3mw4q7m3 118 11 probably probably RB cord-323404-3mw4q7m3 118 12 fluctuate fluctuate VBP cord-323404-3mw4q7m3 118 13 in in IN cord-323404-3mw4q7m3 118 14 their -PRON- PRP$ cord-323404-3mw4q7m3 118 15 size size NN cord-323404-3mw4q7m3 118 16 and and CC cord-323404-3mw4q7m3 118 17 composition composition NN cord-323404-3mw4q7m3 118 18 as as IN cord-323404-3mw4q7m3 118 19 a a DT cord-323404-3mw4q7m3 118 20 result result NN cord-323404-3mw4q7m3 118 21 of of IN cord-323404-3mw4q7m3 118 22 molecular molecular JJ cord-323404-3mw4q7m3 118 23 interactions interaction NNS cord-323404-3mw4q7m3 118 24 at at IN cord-323404-3mw4q7m3 118 25 the the DT cord-323404-3mw4q7m3 118 26 cell cell NN cord-323404-3mw4q7m3 118 27 surface surface NN cord-323404-3mw4q7m3 118 28 . . . cord-323404-3mw4q7m3 119 1 Attachment attachment NN cord-323404-3mw4q7m3 119 2 receptors receptor NNS cord-323404-3mw4q7m3 119 3 and and CC cord-323404-3mw4q7m3 119 4 viral viral JJ cord-323404-3mw4q7m3 119 5 receptors receptor NNS cord-323404-3mw4q7m3 119 6 can can MD cord-323404-3mw4q7m3 119 7 be be VB cord-323404-3mw4q7m3 119 8 recruited recruit VBN cord-323404-3mw4q7m3 119 9 to to IN cord-323404-3mw4q7m3 119 10 , , , cord-323404-3mw4q7m3 119 11 or or CC cord-323404-3mw4q7m3 119 12 excluded exclude VBN cord-323404-3mw4q7m3 119 13 from from IN cord-323404-3mw4q7m3 119 14 , , , cord-323404-3mw4q7m3 119 15 membrane membrane NN cord-323404-3mw4q7m3 119 16 microdomains microdomain NNS cord-323404-3mw4q7m3 119 17 such such JJ cord-323404-3mw4q7m3 119 18 as as IN cord-323404-3mw4q7m3 119 19 rafts raft NNS cord-323404-3mw4q7m3 119 20 , , , cord-323404-3mw4q7m3 119 21 clathrin clathrin NN cord-323404-3mw4q7m3 119 22 - - HYPH cord-323404-3mw4q7m3 119 23 coated coat VBN cord-323404-3mw4q7m3 119 24 pits pit NNS cord-323404-3mw4q7m3 119 25 or or CC cord-323404-3mw4q7m3 119 26 CAVEOLAE CAVEOLAE NNP cord-323404-3mw4q7m3 119 27 5 5 CD cord-323404-3mw4q7m3 119 28 , , , cord-323404-3mw4q7m3 119 29 45 45 CD cord-323404-3mw4q7m3 119 30 . . . cord-323404-3mw4q7m3 120 1 This this DT cord-323404-3mw4q7m3 120 2 remodelling remodelling NN cord-323404-3mw4q7m3 120 3 of of IN cord-323404-3mw4q7m3 120 4 the the DT cord-323404-3mw4q7m3 120 5 host host NN cord-323404-3mw4q7m3 120 6 - - HYPH cord-323404-3mw4q7m3 120 7 cell cell NN cord-323404-3mw4q7m3 120 8 membrane membrane NN cord-323404-3mw4q7m3 120 9 is be VBZ cord-323404-3mw4q7m3 120 10 a a DT cord-323404-3mw4q7m3 120 11 determinant determinant NN cord-323404-3mw4q7m3 120 12 of of IN cord-323404-3mw4q7m3 120 13 the the DT cord-323404-3mw4q7m3 120 14 mechanism mechanism NN cord-323404-3mw4q7m3 120 15 of of IN cord-323404-3mw4q7m3 120 16 virus virus NN cord-323404-3mw4q7m3 120 17 entry entry NN cord-323404-3mw4q7m3 120 18 and and CC cord-323404-3mw4q7m3 120 19 signal signal NN cord-323404-3mw4q7m3 120 20 transduction transduction NN cord-323404-3mw4q7m3 120 21 in in IN cord-323404-3mw4q7m3 120 22 the the DT cord-323404-3mw4q7m3 120 23 host host NN cord-323404-3mw4q7m3 120 24 epithelial epithelial JJ cord-323404-3mw4q7m3 120 25 cell cell NN cord-323404-3mw4q7m3 120 26 46 46 CD cord-323404-3mw4q7m3 120 27 . . . cord-323404-3mw4q7m3 121 1 The the DT cord-323404-3mw4q7m3 121 2 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 121 3 moiety moiety NN cord-323404-3mw4q7m3 121 4 of of IN cord-323404-3mw4q7m3 121 5 host host NN cord-323404-3mw4q7m3 121 6 - - HYPH cord-323404-3mw4q7m3 121 7 cell cell NN cord-323404-3mw4q7m3 121 8 glycoproteins glycoprotein NNS cord-323404-3mw4q7m3 121 9 , , , cord-323404-3mw4q7m3 121 10 glycosphingolipids glycosphingolipid NNS cord-323404-3mw4q7m3 121 11 and and CC cord-323404-3mw4q7m3 121 12 proteoglycans proteoglycan NNS cord-323404-3mw4q7m3 121 13 has have VBZ cord-323404-3mw4q7m3 121 14 emerged emerge VBN cord-323404-3mw4q7m3 121 15 as as IN cord-323404-3mw4q7m3 121 16 a a DT cord-323404-3mw4q7m3 121 17 widely widely RB cord-323404-3mw4q7m3 121 18 used use VBN cord-323404-3mw4q7m3 121 19 virus virus NN cord-323404-3mw4q7m3 121 20 - - HYPH cord-323404-3mw4q7m3 121 21 attachment attachment NN cord-323404-3mw4q7m3 121 22 receptor receptor NN cord-323404-3mw4q7m3 121 23 47 47 CD cord-323404-3mw4q7m3 121 24 . . . cord-323404-3mw4q7m3 122 1 Sialyloligosaccharides sialyloligosaccharide NNS cord-323404-3mw4q7m3 122 2 . . . cord-323404-3mw4q7m3 123 1 Influenza influenza NN cord-323404-3mw4q7m3 123 2 virus virus NN cord-323404-3mw4q7m3 123 3 contains contain VBZ cord-323404-3mw4q7m3 123 4 two two CD cord-323404-3mw4q7m3 123 5 major major JJ cord-323404-3mw4q7m3 123 6 surface surface NN cord-323404-3mw4q7m3 123 7 proteins protein NNS cord-323404-3mw4q7m3 123 8 that that WDT cord-323404-3mw4q7m3 123 9 are be VBP cord-323404-3mw4q7m3 123 10 involved involve VBN cord-323404-3mw4q7m3 123 11 in in IN cord-323404-3mw4q7m3 123 12 viral viral JJ cord-323404-3mw4q7m3 123 13 entry entry NN cord-323404-3mw4q7m3 124 1 -haemagglutinin -haemagglutinin CD cord-323404-3mw4q7m3 125 1 and and CC cord-323404-3mw4q7m3 125 2 neuraminidase neuraminidase NN cord-323404-3mw4q7m3 125 3 -which -which WP$ cord-323404-3mw4q7m3 125 4 bind bind VB cord-323404-3mw4q7m3 125 5 and and CC cord-323404-3mw4q7m3 125 6 cleave cleave VB cord-323404-3mw4q7m3 125 7 SIALYLOLIGOSACCHARIDE SIALYLOLIGOSACCHARIDE NNS cord-323404-3mw4q7m3 125 8 , , , cord-323404-3mw4q7m3 125 9 respectively respectively RB cord-323404-3mw4q7m3 125 10 . . . cord-323404-3mw4q7m3 126 1 Balanced balanced JJ cord-323404-3mw4q7m3 126 2 haemagglutinin haemagglutinin NN cord-323404-3mw4q7m3 126 3 and and CC cord-323404-3mw4q7m3 126 4 neuraminidase neuraminidase NN cord-323404-3mw4q7m3 126 5 activities activity NNS cord-323404-3mw4q7m3 126 6 are be VBP cord-323404-3mw4q7m3 126 7 crucial crucial JJ cord-323404-3mw4q7m3 126 8 for for IN cord-323404-3mw4q7m3 126 9 efficient efficient JJ cord-323404-3mw4q7m3 126 10 viral viral JJ cord-323404-3mw4q7m3 126 11 binding binding NN cord-323404-3mw4q7m3 126 12 to to IN cord-323404-3mw4q7m3 126 13 the the DT cord-323404-3mw4q7m3 126 14 cell cell NN cord-323404-3mw4q7m3 126 15 surface surface NN cord-323404-3mw4q7m3 126 16 , , , cord-323404-3mw4q7m3 126 17 and and CC cord-323404-3mw4q7m3 126 18 for for IN cord-323404-3mw4q7m3 126 19 viral viral JJ cord-323404-3mw4q7m3 126 20 replication replication NN cord-323404-3mw4q7m3 126 21 . . . cord-323404-3mw4q7m3 127 1 Influenza influenza NN cord-323404-3mw4q7m3 127 2 virus virus NN cord-323404-3mw4q7m3 127 3 haemagglutinin haemagglutinin NNP cord-323404-3mw4q7m3 127 4 is be VBZ cord-323404-3mw4q7m3 127 5 one one CD cord-323404-3mw4q7m3 127 6 of of IN cord-323404-3mw4q7m3 127 7 the the DT cord-323404-3mw4q7m3 127 8 best well RBS cord-323404-3mw4q7m3 127 9 - - HYPH cord-323404-3mw4q7m3 127 10 known know VBN cord-323404-3mw4q7m3 127 11 viral viral JJ cord-323404-3mw4q7m3 127 12 lectins lectin NNS cord-323404-3mw4q7m3 127 13 . . . cord-323404-3mw4q7m3 128 1 Its -PRON- PRP$ cord-323404-3mw4q7m3 128 2 trimeric trimeric JJ cord-323404-3mw4q7m3 128 3 organization organization NN cord-323404-3mw4q7m3 128 4 increases increase VBZ cord-323404-3mw4q7m3 128 5 its -PRON- PRP$ cord-323404-3mw4q7m3 128 6 affinity affinity NN cord-323404-3mw4q7m3 128 7 for for IN cord-323404-3mw4q7m3 128 8 sialyloligosaccharide sialyloligosaccharide NN cord-323404-3mw4q7m3 128 9 and and CC cord-323404-3mw4q7m3 128 10 allows allow VBZ cord-323404-3mw4q7m3 128 11 the the DT cord-323404-3mw4q7m3 128 12 virus virus NN cord-323404-3mw4q7m3 128 13 to to TO cord-323404-3mw4q7m3 128 14 bind bind VB cord-323404-3mw4q7m3 128 15 to to IN cord-323404-3mw4q7m3 128 16 the the DT cord-323404-3mw4q7m3 128 17 surface surface NN cord-323404-3mw4q7m3 128 18 of of IN cord-323404-3mw4q7m3 128 19 the the DT cord-323404-3mw4q7m3 128 20 epithelial epithelial JJ cord-323404-3mw4q7m3 128 21 cell cell NN cord-323404-3mw4q7m3 128 22 21 21 CD cord-323404-3mw4q7m3 128 23 . . . cord-323404-3mw4q7m3 129 1 The the DT cord-323404-3mw4q7m3 129 2 epithelial epithelial JJ cord-323404-3mw4q7m3 129 3 molecules molecule NNS cord-323404-3mw4q7m3 129 4 that that WDT cord-323404-3mw4q7m3 129 5 contain contain VBP cord-323404-3mw4q7m3 129 6 this this DT cord-323404-3mw4q7m3 129 7 sialyloligosaccharide sialyloligosaccharide NN cord-323404-3mw4q7m3 129 8 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 129 9 receptor receptor NN cord-323404-3mw4q7m3 129 10 remain remain VBP cord-323404-3mw4q7m3 129 11 unknown unknown JJ cord-323404-3mw4q7m3 129 12 , , , cord-323404-3mw4q7m3 129 13 although although IN cord-323404-3mw4q7m3 129 14 they -PRON- PRP cord-323404-3mw4q7m3 129 15 could could MD cord-323404-3mw4q7m3 129 16 be be VB cord-323404-3mw4q7m3 129 17 glycoproteins glycoprotein NNS cord-323404-3mw4q7m3 129 18 or or CC cord-323404-3mw4q7m3 129 19 glycosphingolipids glycosphingolipid NNS cord-323404-3mw4q7m3 129 20 48 48 CD cord-323404-3mw4q7m3 129 21 . . . cord-323404-3mw4q7m3 130 1 On on IN cord-323404-3mw4q7m3 130 2 endocytosis endocytosis NN cord-323404-3mw4q7m3 130 3 of of IN cord-323404-3mw4q7m3 130 4 the the DT cord-323404-3mw4q7m3 130 5 influenza influenza NN cord-323404-3mw4q7m3 130 6 virus virus NN cord-323404-3mw4q7m3 130 7 , , , cord-323404-3mw4q7m3 130 8 haemagglutinin haemagglutinin NNP cord-323404-3mw4q7m3 130 9 is be VBZ cord-323404-3mw4q7m3 130 10 cleaved cleave VBN cord-323404-3mw4q7m3 130 11 into into IN cord-323404-3mw4q7m3 130 12 haemagglutinin haemagglutinin NNP cord-323404-3mw4q7m3 130 13 1 1 CD cord-323404-3mw4q7m3 130 14 and and CC cord-323404-3mw4q7m3 130 15 haemagglutinin haemagglutinin NNP cord-323404-3mw4q7m3 130 16 2 2 CD cord-323404-3mw4q7m3 130 17 . . . cord-323404-3mw4q7m3 131 1 Whereas whereas IN cord-323404-3mw4q7m3 131 2 low low JJ cord-323404-3mw4q7m3 131 3 endosomal endosomal NNP cord-323404-3mw4q7m3 131 4 pH pH NNP cord-323404-3mw4q7m3 131 5 exposes expose VBZ cord-323404-3mw4q7m3 131 6 the the DT cord-323404-3mw4q7m3 131 7 haemagglutinin haemagglutinin NNP cord-323404-3mw4q7m3 131 8 2 2 CD cord-323404-3mw4q7m3 131 9 fusionpeptide fusionpeptide NN cord-323404-3mw4q7m3 131 10 domain domain NN cord-323404-3mw4q7m3 131 11 , , , cord-323404-3mw4q7m3 131 12 haemagglutinin haemagglutinin NNP cord-323404-3mw4q7m3 131 13 1 1 CD cord-323404-3mw4q7m3 131 14 mediates mediate VBZ cord-323404-3mw4q7m3 131 15 viral viral JJ cord-323404-3mw4q7m3 131 16 fusion fusion NN cord-323404-3mw4q7m3 131 17 with with IN cord-323404-3mw4q7m3 131 18 the the DT cord-323404-3mw4q7m3 131 19 endosomal endosomal NNP cord-323404-3mw4q7m3 131 20 membrane membrane NN cord-323404-3mw4q7m3 131 21 48 48 CD cord-323404-3mw4q7m3 131 22 . . . cord-323404-3mw4q7m3 132 1 Similarly similarly RB cord-323404-3mw4q7m3 132 2 , , , cord-323404-3mw4q7m3 132 3 human human JJ cord-323404-3mw4q7m3 132 4 JC JC NNP cord-323404-3mw4q7m3 132 5 virus virus NN cord-323404-3mw4q7m3 132 6 49 49 CD cord-323404-3mw4q7m3 132 7 and and CC cord-323404-3mw4q7m3 132 8 Sendai Sendai NNP cord-323404-3mw4q7m3 132 9 50 50 CD cord-323404-3mw4q7m3 132 10 virus virus NN cord-323404-3mw4q7m3 132 11 , , , cord-323404-3mw4q7m3 132 12 as as RB cord-323404-3mw4q7m3 132 13 well well RB cord-323404-3mw4q7m3 132 14 as as IN cord-323404-3mw4q7m3 132 15 sialyloligosaccharide sialyloligosaccharide NN cord-323404-3mw4q7m3 132 16 - - HYPH cord-323404-3mw4q7m3 132 17 dependent dependent JJ cord-323404-3mw4q7m3 132 18 strains strain NNS cord-323404-3mw4q7m3 132 19 of of IN cord-323404-3mw4q7m3 132 20 rotavirus rotavirus JJ cord-323404-3mw4q7m3 132 21 20 20 CD cord-323404-3mw4q7m3 132 22 and and CC cord-323404-3mw4q7m3 132 23 reovirus reovirus NNP cord-323404-3mw4q7m3 132 24 , , , cord-323404-3mw4q7m3 132 25 also also RB cord-323404-3mw4q7m3 132 26 attach attach VB cord-323404-3mw4q7m3 132 27 themselves -PRON- PRP cord-323404-3mw4q7m3 132 28 to to IN cord-323404-3mw4q7m3 132 29 epithelial epithelial JJ cord-323404-3mw4q7m3 132 30 cells cell NNS cord-323404-3mw4q7m3 132 31 to to TO cord-323404-3mw4q7m3 132 32 block block VB cord-323404-3mw4q7m3 132 33 or or CC cord-323404-3mw4q7m3 132 34 abuse abuse VB cord-323404-3mw4q7m3 132 35 normal normal JJ cord-323404-3mw4q7m3 132 36 cell cell NN cord-323404-3mw4q7m3 132 37 processes process NNS cord-323404-3mw4q7m3 132 38 and and CC cord-323404-3mw4q7m3 132 39 , , , cord-323404-3mw4q7m3 132 40 as as IN cord-323404-3mw4q7m3 132 41 with with IN cord-323404-3mw4q7m3 132 42 bacteria bacteria NNS cord-323404-3mw4q7m3 132 43 43 43 CD cord-323404-3mw4q7m3 132 44 , , , cord-323404-3mw4q7m3 132 45 the the DT cord-323404-3mw4q7m3 132 46 surface surface NN cord-323404-3mw4q7m3 132 47 proteins protein NNS cord-323404-3mw4q7m3 132 48 of of IN cord-323404-3mw4q7m3 132 49 enveloped envelop VBN cord-323404-3mw4q7m3 132 50 or or CC cord-323404-3mw4q7m3 132 51 naked naked JJ cord-323404-3mw4q7m3 132 52 viruses virus NNS cord-323404-3mw4q7m3 132 53 bind bind VBP cord-323404-3mw4q7m3 132 54 to to IN cord-323404-3mw4q7m3 132 55 host host NN cord-323404-3mw4q7m3 132 56 - - HYPH cord-323404-3mw4q7m3 132 57 cell cell NN cord-323404-3mw4q7m3 132 58 molecules molecule NNS cord-323404-3mw4q7m3 132 59 that that WDT cord-323404-3mw4q7m3 132 60 have have VBP cord-323404-3mw4q7m3 132 61 receptor receptor NN cord-323404-3mw4q7m3 132 62 functions function NNS cord-323404-3mw4q7m3 132 63 . . . cord-323404-3mw4q7m3 133 1 So so RB cord-323404-3mw4q7m3 133 2 , , , cord-323404-3mw4q7m3 133 3 viruses virus NNS cord-323404-3mw4q7m3 133 4 mimic mimic VBP cord-323404-3mw4q7m3 133 5 the the DT cord-323404-3mw4q7m3 133 6 natural natural JJ cord-323404-3mw4q7m3 133 7 ligand ligand NN cord-323404-3mw4q7m3 133 8 of of IN cord-323404-3mw4q7m3 133 9 these these DT cord-323404-3mw4q7m3 133 10 receptors receptor NNS cord-323404-3mw4q7m3 133 11 and and CC cord-323404-3mw4q7m3 133 12 interfere interfere VB cord-323404-3mw4q7m3 133 13 with with IN cord-323404-3mw4q7m3 133 14 their -PRON- PRP$ cord-323404-3mw4q7m3 133 15 signalling signalling NN cord-323404-3mw4q7m3 133 16 to to TO cord-323404-3mw4q7m3 133 17 promote promote VB cord-323404-3mw4q7m3 133 18 viral viral JJ cord-323404-3mw4q7m3 133 19 entry entry NN cord-323404-3mw4q7m3 133 20 into into IN cord-323404-3mw4q7m3 133 21 the the DT cord-323404-3mw4q7m3 133 22 cell cell NN cord-323404-3mw4q7m3 133 23 and and CC cord-323404-3mw4q7m3 133 24 the the DT cord-323404-3mw4q7m3 133 25 spread spread NN cord-323404-3mw4q7m3 133 26 of of IN cord-323404-3mw4q7m3 133 27 infection infection NN cord-323404-3mw4q7m3 133 28 ( ( -LRB- cord-323404-3mw4q7m3 133 29 BOX BOX NNP cord-323404-3mw4q7m3 133 30 4 4 CD cord-323404-3mw4q7m3 133 31 ) ) -RRB- cord-323404-3mw4q7m3 133 32 . . . cord-323404-3mw4q7m3 134 1 The the DT cord-323404-3mw4q7m3 134 2 classical classical JJ cord-323404-3mw4q7m3 134 3 concept concept NN cord-323404-3mw4q7m3 134 4 of of IN cord-323404-3mw4q7m3 134 5 viral viral JJ cord-323404-3mw4q7m3 134 6 receptors receptor NNS cord-323404-3mw4q7m3 134 7 has have VBZ cord-323404-3mw4q7m3 134 8 been be VBN cord-323404-3mw4q7m3 134 9 superseded supersede VBN cord-323404-3mw4q7m3 134 10 by by IN cord-323404-3mw4q7m3 134 11 new new JJ cord-323404-3mw4q7m3 134 12 data datum NNS cord-323404-3mw4q7m3 134 13 , , , cord-323404-3mw4q7m3 134 14 which which WDT cord-323404-3mw4q7m3 134 15 indicate indicate VBP cord-323404-3mw4q7m3 134 16 that that IN cord-323404-3mw4q7m3 134 17 the the DT cord-323404-3mw4q7m3 134 18 binding binding NN cord-323404-3mw4q7m3 134 19 and and CC cord-323404-3mw4q7m3 134 20 entry entry NN cord-323404-3mw4q7m3 134 21 of of IN cord-323404-3mw4q7m3 134 22 viruses virus NNS cord-323404-3mw4q7m3 134 23 is be VBZ cord-323404-3mw4q7m3 134 24 a a DT cord-323404-3mw4q7m3 134 25 multi multi JJ cord-323404-3mw4q7m3 134 26 - - JJ cord-323404-3mw4q7m3 134 27 step step JJ cord-323404-3mw4q7m3 134 28 process process NN cord-323404-3mw4q7m3 134 29 that that WDT cord-323404-3mw4q7m3 134 30 involves involve VBZ cord-323404-3mw4q7m3 134 31 the the DT cord-323404-3mw4q7m3 134 32 recognition recognition NN cord-323404-3mw4q7m3 134 33 of of IN cord-323404-3mw4q7m3 134 34 , , , cord-323404-3mw4q7m3 134 35 and and CC cord-323404-3mw4q7m3 134 36 attachment attachment NN cord-323404-3mw4q7m3 134 37 to to IN cord-323404-3mw4q7m3 134 38 , , , cord-323404-3mw4q7m3 134 39 the the DT cord-323404-3mw4q7m3 134 40 epithelial epithelial JJ cord-323404-3mw4q7m3 134 41 - - HYPH cord-323404-3mw4q7m3 134 42 cell cell NN cord-323404-3mw4q7m3 134 43 surface surface NN cord-323404-3mw4q7m3 134 44 . . . cord-323404-3mw4q7m3 135 1 This this DT cord-323404-3mw4q7m3 135 2 is be VBZ cord-323404-3mw4q7m3 135 3 followed follow VBN cord-323404-3mw4q7m3 135 4 either either CC cord-323404-3mw4q7m3 135 5 by by IN cord-323404-3mw4q7m3 135 6 penetration penetration NN cord-323404-3mw4q7m3 135 7 of of IN cord-323404-3mw4q7m3 135 8 the the DT cord-323404-3mw4q7m3 135 9 host host NN cord-323404-3mw4q7m3 135 10 - - HYPH cord-323404-3mw4q7m3 135 11 cell cell NN cord-323404-3mw4q7m3 135 12 cytosol cytosol NN cord-323404-3mw4q7m3 135 13 , , , cord-323404-3mw4q7m3 135 14 with with IN cord-323404-3mw4q7m3 135 15 infection infection NN cord-323404-3mw4q7m3 135 16 of of IN cord-323404-3mw4q7m3 135 17 the the DT cord-323404-3mw4q7m3 135 18 cell cell NN cord-323404-3mw4q7m3 135 19 , , , cord-323404-3mw4q7m3 135 20 or or CC cord-323404-3mw4q7m3 135 21 by by IN cord-323404-3mw4q7m3 135 22 transcytosis transcytosis NNP cord-323404-3mw4q7m3 135 23 . . . cord-323404-3mw4q7m3 136 1 Each each DT cord-323404-3mw4q7m3 136 2 step step NN cord-323404-3mw4q7m3 136 3 involves involve VBZ cord-323404-3mw4q7m3 136 4 many many JJ cord-323404-3mw4q7m3 136 5 host host NN cord-323404-3mw4q7m3 136 6 - - HYPH cord-323404-3mw4q7m3 136 7 cell cell NN cord-323404-3mw4q7m3 136 8 receptors receptor NNS cord-323404-3mw4q7m3 136 9 . . . cord-323404-3mw4q7m3 137 1 These these DT cord-323404-3mw4q7m3 137 2 receptors receptor NNS cord-323404-3mw4q7m3 137 3 range range VBP cord-323404-3mw4q7m3 137 4 from from IN cord-323404-3mw4q7m3 137 5 ubiquitous ubiquitous JJ cord-323404-3mw4q7m3 137 6 cell cell NN cord-323404-3mw4q7m3 137 7 - - HYPH cord-323404-3mw4q7m3 137 8 surface surface NN cord-323404-3mw4q7m3 137 9 - - HYPH cord-323404-3mw4q7m3 137 10 associated associate VBN cord-323404-3mw4q7m3 137 11 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 137 12 moieties moiety NNS cord-323404-3mw4q7m3 137 13 of of IN cord-323404-3mw4q7m3 137 14 membrane membrane NN cord-323404-3mw4q7m3 137 15 glycoproteins glycoprotein NNS cord-323404-3mw4q7m3 137 16 , , , cord-323404-3mw4q7m3 137 17 proteoglycans proteoglycan NNS cord-323404-3mw4q7m3 137 18 or or CC cord-323404-3mw4q7m3 137 19 glycolipids glycolipid NNS cord-323404-3mw4q7m3 137 20 -which -which JJS cord-323404-3mw4q7m3 137 21 are be VBP cord-323404-3mw4q7m3 137 22 inserted insert VBN cord-323404-3mw4q7m3 137 23 in in IN cord-323404-3mw4q7m3 137 24 the the DT cord-323404-3mw4q7m3 137 25 dynamic dynamic JJ cord-323404-3mw4q7m3 137 26 bilayer bilayer NN cord-323404-3mw4q7m3 137 27 of of IN cord-323404-3mw4q7m3 137 28 the the DT cord-323404-3mw4q7m3 137 29 target target NN cord-323404-3mw4q7m3 137 30 - - HYPH cord-323404-3mw4q7m3 137 31 cell cell NN cord-323404-3mw4q7m3 137 32 membrane membrane NN cord-323404-3mw4q7m3 137 33 and and CC cord-323404-3mw4q7m3 137 34 usually usually RB cord-323404-3mw4q7m3 137 35 act act VB cord-323404-3mw4q7m3 137 36 as as IN cord-323404-3mw4q7m3 137 37 attachment attachment NN cord-323404-3mw4q7m3 137 38 receptors receptor NNS cord-323404-3mw4q7m3 137 39 -to -to IN cord-323404-3mw4q7m3 137 40 cell cell NN cord-323404-3mw4q7m3 137 41 - - HYPH cord-323404-3mw4q7m3 137 42 specific specific JJ cord-323404-3mw4q7m3 137 43 transmembrane transmembrane NN cord-323404-3mw4q7m3 137 44 proteins protein NNS cord-323404-3mw4q7m3 137 45 , , , cord-323404-3mw4q7m3 137 46 which which WDT cord-323404-3mw4q7m3 137 47 can can MD cord-323404-3mw4q7m3 137 48 mediate mediate VB cord-323404-3mw4q7m3 137 49 numerous numerous JJ cord-323404-3mw4q7m3 137 50 different different JJ cord-323404-3mw4q7m3 137 51 steps step NNS cord-323404-3mw4q7m3 137 52 . . . cord-323404-3mw4q7m3 138 1 These these DT cord-323404-3mw4q7m3 138 2 many many JJ cord-323404-3mw4q7m3 138 3 steps step NNS cord-323404-3mw4q7m3 138 4 are be VBP cord-323404-3mw4q7m3 138 5 not not RB cord-323404-3mw4q7m3 138 6 independent independent JJ cord-323404-3mw4q7m3 138 7 of of IN cord-323404-3mw4q7m3 138 8 each each DT cord-323404-3mw4q7m3 138 9 other other JJ cord-323404-3mw4q7m3 138 10 , , , cord-323404-3mw4q7m3 138 11 but but CC cord-323404-3mw4q7m3 138 12 their -PRON- PRP$ cord-323404-3mw4q7m3 138 13 spatio spatio JJ cord-323404-3mw4q7m3 138 14 - - HYPH cord-323404-3mw4q7m3 138 15 temporal temporal JJ cord-323404-3mw4q7m3 138 16 sequence sequence NN cord-323404-3mw4q7m3 138 17 in in IN cord-323404-3mw4q7m3 138 18 the the DT cord-323404-3mw4q7m3 138 19 _SP cord-323404-3mw4q7m3 138 20 . . . cord-323404-3mw4q7m3 139 1 Both both DT cord-323404-3mw4q7m3 139 2 contain contain VBP cord-323404-3mw4q7m3 139 3 viruses virus NNS cord-323404-3mw4q7m3 139 4 that that WDT cord-323404-3mw4q7m3 139 5 use use VBP cord-323404-3mw4q7m3 139 6 either either CC cord-323404-3mw4q7m3 139 7 the the DT cord-323404-3mw4q7m3 139 8 chemokine chemokine NN cord-323404-3mw4q7m3 139 9 receptor receptor NN cord-323404-3mw4q7m3 139 10 CCR5 CCR5 NNP cord-323404-3mw4q7m3 140 1 ( ( -LRB- cord-323404-3mw4q7m3 140 2 R5 R5 NNP cord-323404-3mw4q7m3 140 3 virus virus NN cord-323404-3mw4q7m3 140 4 ; ; , cord-323404-3mw4q7m3 140 5 found find VBN cord-323404-3mw4q7m3 140 6 in in IN cord-323404-3mw4q7m3 140 7 most most RBS cord-323404-3mw4q7m3 140 8 acutely acutely RB cord-323404-3mw4q7m3 140 9 infected infected JJ cord-323404-3mw4q7m3 140 10 patients patient NNS cord-323404-3mw4q7m3 140 11 , , , cord-323404-3mw4q7m3 140 12 and and CC cord-323404-3mw4q7m3 140 13 therefore therefore RB cord-323404-3mw4q7m3 140 14 thought think VBD cord-323404-3mw4q7m3 140 15 to to TO cord-323404-3mw4q7m3 140 16 be be VB cord-323404-3mw4q7m3 140 17 the the DT cord-323404-3mw4q7m3 140 18 main main JJ cord-323404-3mw4q7m3 140 19 vector vector NN cord-323404-3mw4q7m3 140 20 of of IN cord-323404-3mw4q7m3 140 21 infection infection NN cord-323404-3mw4q7m3 140 22 ) ) -RRB- cord-323404-3mw4q7m3 140 23 or or CC cord-323404-3mw4q7m3 140 24 CXCR4 CXCR4 NNP cord-323404-3mw4q7m3 140 25 ( ( -LRB- cord-323404-3mw4q7m3 140 26 X4 X4 NNP cord-323404-3mw4q7m3 140 27 virus virus NN cord-323404-3mw4q7m3 140 28 ; ; , cord-323404-3mw4q7m3 140 29 found find VBN cord-323404-3mw4q7m3 140 30 later later RB cord-323404-3mw4q7m3 140 31 in in IN cord-323404-3mw4q7m3 140 32 patients patient NNS cord-323404-3mw4q7m3 140 33 , , , cord-323404-3mw4q7m3 140 34 as as IN cord-323404-3mw4q7m3 140 35 the the DT cord-323404-3mw4q7m3 140 36 disease disease NN cord-323404-3mw4q7m3 140 37 progresses progress VBZ cord-323404-3mw4q7m3 140 38 ) ) -RRB- cord-323404-3mw4q7m3 140 39 for for IN cord-323404-3mw4q7m3 140 40 fusion fusion NN cord-323404-3mw4q7m3 140 41 and/or and/or CC cord-323404-3mw4q7m3 140 42 infection infection NN cord-323404-3mw4q7m3 140 43 . . . cord-323404-3mw4q7m3 141 1 In in IN cord-323404-3mw4q7m3 141 2 the the DT cord-323404-3mw4q7m3 141 3 upper upper JJ cord-323404-3mw4q7m3 141 4 small small JJ cord-323404-3mw4q7m3 141 5 intestine intestine NN cord-323404-3mw4q7m3 141 6 , , , cord-323404-3mw4q7m3 141 7 galactosyl galactosyl NN cord-323404-3mw4q7m3 141 8 - - HYPH cord-323404-3mw4q7m3 141 9 ceramide ceramide NN cord-323404-3mw4q7m3 141 10 ( ( -LRB- cord-323404-3mw4q7m3 141 11 GalCer galcer NN cord-323404-3mw4q7m3 141 12 ) ) -RRB- cord-323404-3mw4q7m3 141 13 + + CC cord-323404-3mw4q7m3 141 14 /CCR5 /ccr5 NN cord-323404-3mw4q7m3 141 15 + + CC cord-323404-3mw4q7m3 141 16 /CXCR4 /CXCR4 . cord-323404-3mw4q7m3 142 1 − − CD cord-323404-3mw4q7m3 142 2 epithelial epithelial JJ cord-323404-3mw4q7m3 142 3 cells cell NNS cord-323404-3mw4q7m3 143 1 endocytose endocytose NNP cord-323404-3mw4q7m3 143 2 cell cell NN cord-323404-3mw4q7m3 143 3 - - HYPH cord-323404-3mw4q7m3 143 4 free free JJ cord-323404-3mw4q7m3 143 5 R5 R5 NNP cord-323404-3mw4q7m3 143 6 virus virus NN cord-323404-3mw4q7m3 143 7 at at IN cord-323404-3mw4q7m3 143 8 the the DT cord-323404-3mw4q7m3 143 9 lumenal lumenal JJ cord-323404-3mw4q7m3 143 10 surface surface NN cord-323404-3mw4q7m3 143 11 in in IN cord-323404-3mw4q7m3 143 12 a a DT cord-323404-3mw4q7m3 143 13 galactosyl galactosyl NN cord-323404-3mw4q7m3 143 14 ceramide ceramide NN cord-323404-3mw4q7m3 143 15 / / SYM cord-323404-3mw4q7m3 143 16 CCR5-receptor CCR5-receptor NNP cord-323404-3mw4q7m3 143 17 - - HYPH cord-323404-3mw4q7m3 143 18 mediated mediate VBN cord-323404-3mw4q7m3 143 19 mechanism mechanism NN cord-323404-3mw4q7m3 143 20 , , , cord-323404-3mw4q7m3 143 21 whereas whereas IN cord-323404-3mw4q7m3 143 22 cellfree cellfree NNP cord-323404-3mw4q7m3 143 23 X4 X4 NNP cord-323404-3mw4q7m3 143 24 viruses virus NNS cord-323404-3mw4q7m3 143 25 can can MD cord-323404-3mw4q7m3 143 26 not not RB cord-323404-3mw4q7m3 143 27 enter enter VB cord-323404-3mw4q7m3 143 28 these these DT cord-323404-3mw4q7m3 143 29 CXCR4epithelial CXCR4epithelial NNP cord-323404-3mw4q7m3 143 30 cells cell NNS cord-323404-3mw4q7m3 143 31 4 4 CD cord-323404-3mw4q7m3 143 32 . . . cord-323404-3mw4q7m3 144 1 Alternatively alternatively RB cord-323404-3mw4q7m3 144 2 , , , cord-323404-3mw4q7m3 144 3 R5 R5 NNP cord-323404-3mw4q7m3 144 4 ( ( -LRB- cord-323404-3mw4q7m3 144 5 or or CC cord-323404-3mw4q7m3 144 6 X4)-infected x4)-infecte VBN cord-323404-3mw4q7m3 144 7 MONONUCLEAR MONONUCLEAR NNP cord-323404-3mw4q7m3 144 8 CELLS cell NNS cord-323404-3mw4q7m3 144 9 bind bind VBP cord-323404-3mw4q7m3 144 10 to to IN cord-323404-3mw4q7m3 144 11 the the DT cord-323404-3mw4q7m3 144 12 epithelial epithelial JJ cord-323404-3mw4q7m3 144 13 cell cell NN cord-323404-3mw4q7m3 144 14 and and CC cord-323404-3mw4q7m3 144 15 induce induce VB cord-323404-3mw4q7m3 144 16 the the DT cord-323404-3mw4q7m3 144 17 polarized polarized JJ cord-323404-3mw4q7m3 144 18 budding budding NN cord-323404-3mw4q7m3 144 19 of of IN cord-323404-3mw4q7m3 144 20 newly newly RB cord-323404-3mw4q7m3 144 21 formed form VBN cord-323404-3mw4q7m3 144 22 R5 R5 NNP cord-323404-3mw4q7m3 144 23 ( ( -LRB- cord-323404-3mw4q7m3 144 24 or or CC cord-323404-3mw4q7m3 144 25 X4 X4 NNP cord-323404-3mw4q7m3 144 26 ) ) -RRB- cord-323404-3mw4q7m3 144 27 viruses virus NNS cord-323404-3mw4q7m3 144 28 , , , cord-323404-3mw4q7m3 144 29 which which WDT cord-323404-3mw4q7m3 144 30 are be VBP cord-323404-3mw4q7m3 144 31 rapidly rapidly RB cord-323404-3mw4q7m3 144 32 endocytosed endocytose VBN cord-323404-3mw4q7m3 144 33 through through IN cord-323404-3mw4q7m3 144 34 GalCer GalCer NNP cord-323404-3mw4q7m3 144 35 that that WDT cord-323404-3mw4q7m3 144 36 is be VBZ cord-323404-3mw4q7m3 144 37 present present JJ cord-323404-3mw4q7m3 144 38 in in IN cord-323404-3mw4q7m3 144 39 raft raft NN cord-323404-3mw4q7m3 144 40 microdomains microdomain NNS cord-323404-3mw4q7m3 144 41 3 3 CD cord-323404-3mw4q7m3 144 42 , , , cord-323404-3mw4q7m3 144 43 91 91 CD cord-323404-3mw4q7m3 144 44 . . . cord-323404-3mw4q7m3 145 1 HIV HIV NNP cord-323404-3mw4q7m3 145 2 transcytoses transcytose NNS cord-323404-3mw4q7m3 145 3 across across IN cord-323404-3mw4q7m3 145 4 epithelial epithelial JJ cord-323404-3mw4q7m3 145 5 cells cell NNS cord-323404-3mw4q7m3 145 6 to to IN cord-323404-3mw4q7m3 145 7 the the DT cord-323404-3mw4q7m3 145 8 serosal serosal NN cord-323404-3mw4q7m3 145 9 surface surface NN cord-323404-3mw4q7m3 145 10 , , , cord-323404-3mw4q7m3 145 11 where where WRB cord-323404-3mw4q7m3 145 12 fusion fusion NN cord-323404-3mw4q7m3 145 13 of of IN cord-323404-3mw4q7m3 145 14 the the DT cord-323404-3mw4q7m3 145 15 transcytotic transcytotic JJ cord-323404-3mw4q7m3 145 16 vesicles vesicle NNS cord-323404-3mw4q7m3 145 17 releases release VBZ cord-323404-3mw4q7m3 145 18 virus virus NN cord-323404-3mw4q7m3 145 19 into into IN cord-323404-3mw4q7m3 145 20 the the DT cord-323404-3mw4q7m3 145 21 LAMINA LAMINA NNP cord-323404-3mw4q7m3 145 22 PROPRIA PROPRIA NNS cord-323404-3mw4q7m3 145 23 . . . cord-323404-3mw4q7m3 146 1 Here here RB cord-323404-3mw4q7m3 146 2 , , , cord-323404-3mw4q7m3 146 3 R5 r5 NN cord-323404-3mw4q7m3 146 4 viruses virus NNS cord-323404-3mw4q7m3 146 5 infect infect VBP cord-323404-3mw4q7m3 146 6 the the DT cord-323404-3mw4q7m3 146 7 CCR5 CCR5 NNP cord-323404-3mw4q7m3 147 1 + + CC cord-323404-3mw4q7m3 147 2 /CXCR4 /CXCR4 . cord-323404-3mw4q7m3 148 1 + + CC cord-323404-3mw4q7m3 148 2 /CD4 /CD4 . cord-323404-3mw4q7m3 149 1 + + CC cord-323404-3mw4q7m3 149 2 lamina lamina NNP cord-323404-3mw4q7m3 149 3 propria propria FW cord-323404-3mw4q7m3 149 4 T T NNP cord-323404-3mw4q7m3 149 5 lymphocyte lymphocyte NN cord-323404-3mw4q7m3 149 6 , , , cord-323404-3mw4q7m3 149 7 but but CC cord-323404-3mw4q7m3 149 8 not not RB cord-323404-3mw4q7m3 149 9 the the DT cord-323404-3mw4q7m3 149 10 CCR5 CCR5 NNP cord-323404-3mw4q7m3 149 11 − − NNP cord-323404-3mw4q7m3 149 12 /CXCR4 /CXCR4 . cord-323404-3mw4q7m3 150 1 − − NNP cord-323404-3mw4q7m3 150 2 /CD4 /CD4 . cord-323404-3mw4q7m3 151 1 + + CC cord-323404-3mw4q7m3 151 2 intestinal intestinal JJ cord-323404-3mw4q7m3 151 3 macrophage macrophage NN cord-323404-3mw4q7m3 151 4 93 93 CD cord-323404-3mw4q7m3 151 5 . . . cord-323404-3mw4q7m3 152 1 By by IN cord-323404-3mw4q7m3 152 2 contrast contrast NN cord-323404-3mw4q7m3 152 3 , , , cord-323404-3mw4q7m3 152 4 the the DT cord-323404-3mw4q7m3 152 5 infection infection NN cord-323404-3mw4q7m3 152 6 of of IN cord-323404-3mw4q7m3 152 7 intestinal intestinal JJ cord-323404-3mw4q7m3 152 8 CXCR4 CXCR4 NNS cord-323404-3mw4q7m3 152 9 + + CC cord-323404-3mw4q7m3 152 10 /CD4 /CD4 NNS cord-323404-3mw4q7m3 152 11 + + CC cord-323404-3mw4q7m3 152 12 T t NN cord-323404-3mw4q7m3 152 13 cells cell NNS cord-323404-3mw4q7m3 152 14 by by IN cord-323404-3mw4q7m3 152 15 X4 X4 NNP cord-323404-3mw4q7m3 152 16 viruses virus NNS cord-323404-3mw4q7m3 152 17 that that WDT cord-323404-3mw4q7m3 152 18 are be VBP cord-323404-3mw4q7m3 152 19 transcytosed transcytose VBN cord-323404-3mw4q7m3 152 20 from from IN cord-323404-3mw4q7m3 152 21 X4-infected x4-infecte VBN cord-323404-3mw4q7m3 152 22 cells cell NNS cord-323404-3mw4q7m3 152 23 is be VBZ cord-323404-3mw4q7m3 152 24 blocked block VBN cord-323404-3mw4q7m3 152 25 by by IN cord-323404-3mw4q7m3 152 26 stromal stromal NN cord-323404-3mw4q7m3 152 27 - - HYPH cord-323404-3mw4q7m3 152 28 cell cell NN cord-323404-3mw4q7m3 152 29 - - HYPH cord-323404-3mw4q7m3 152 30 derived derive VBN cord-323404-3mw4q7m3 152 31 factor factor NN cord-323404-3mw4q7m3 152 32 ( ( -LRB- cord-323404-3mw4q7m3 152 33 SDF)-1 SDF)-1 NNP cord-323404-3mw4q7m3 152 34 that that WDT cord-323404-3mw4q7m3 152 35 is be VBZ cord-323404-3mw4q7m3 152 36 present present JJ cord-323404-3mw4q7m3 152 37 in in IN cord-323404-3mw4q7m3 152 38 the the DT cord-323404-3mw4q7m3 152 39 mucosa mucosa JJ cord-323404-3mw4q7m3 152 40 94 94 CD cord-323404-3mw4q7m3 152 41 assembled assemble VBD cord-323404-3mw4q7m3 152 42 in in IN cord-323404-3mw4q7m3 152 43 rafts raft NNS cord-323404-3mw4q7m3 152 44 for for IN cord-323404-3mw4q7m3 152 45 virus virus NN cord-323404-3mw4q7m3 152 46 attachment attachment NN cord-323404-3mw4q7m3 152 47 and and CC cord-323404-3mw4q7m3 152 48 entry entry NN cord-323404-3mw4q7m3 152 49 into into IN cord-323404-3mw4q7m3 152 50 the the DT cord-323404-3mw4q7m3 152 51 epithelial epithelial JJ cord-323404-3mw4q7m3 152 52 cell cell NN cord-323404-3mw4q7m3 152 53 . . . cord-323404-3mw4q7m3 153 1 This this DT cord-323404-3mw4q7m3 153 2 virus virus NN cord-323404-3mw4q7m3 153 3 - - HYPH cord-323404-3mw4q7m3 153 4 cell cell NN cord-323404-3mw4q7m3 153 5 interaction interaction NN cord-323404-3mw4q7m3 153 6 , , , cord-323404-3mw4q7m3 153 7 which which WDT cord-323404-3mw4q7m3 153 8 involves involve VBZ cord-323404-3mw4q7m3 153 9 several several JJ cord-323404-3mw4q7m3 153 10 species specie NNS cord-323404-3mw4q7m3 153 11 of of IN cord-323404-3mw4q7m3 153 12 viral viral JJ cord-323404-3mw4q7m3 153 13 surface surface NN cord-323404-3mw4q7m3 153 14 protein protein NN cord-323404-3mw4q7m3 153 15 , , , cord-323404-3mw4q7m3 153 16 probably probably RB cord-323404-3mw4q7m3 153 17 stabilizes stabilize VBZ cord-323404-3mw4q7m3 153 18 raft raft NN cord-323404-3mw4q7m3 153 19 microdomains microdomain NNS cord-323404-3mw4q7m3 153 20 , , , cord-323404-3mw4q7m3 153 21 allowing allow VBG cord-323404-3mw4q7m3 153 22 signal signal NN cord-323404-3mw4q7m3 153 23 transduction transduction NN cord-323404-3mw4q7m3 153 24 in in IN cord-323404-3mw4q7m3 153 25 the the DT cord-323404-3mw4q7m3 153 26 epithelial epithelial JJ cord-323404-3mw4q7m3 153 27 cell cell NN cord-323404-3mw4q7m3 153 28 and and CC cord-323404-3mw4q7m3 153 29 endocytosis endocytosis NN cord-323404-3mw4q7m3 153 30 of of IN cord-323404-3mw4q7m3 153 31 the the DT cord-323404-3mw4q7m3 153 32 virus virus NN cord-323404-3mw4q7m3 153 33 . . . cord-323404-3mw4q7m3 154 1 A a DT cord-323404-3mw4q7m3 154 2 galactosylceramide galactosylceramide NN cord-323404-3mw4q7m3 154 3 / / SYM cord-323404-3mw4q7m3 154 4 sphingomyelin sphingomyelin NN cord-323404-3mw4q7m3 154 5 - - HYPH cord-323404-3mw4q7m3 154 6 binding bind VBG cord-323404-3mw4q7m3 154 7 motif motif NN cord-323404-3mw4q7m3 154 8 , , , cord-323404-3mw4q7m3 154 9 which which WDT cord-323404-3mw4q7m3 154 10 is be VBZ cord-323404-3mw4q7m3 154 11 similar similar JJ cord-323404-3mw4q7m3 154 12 to to IN cord-323404-3mw4q7m3 154 13 that that DT cord-323404-3mw4q7m3 154 14 found find VBN cord-323404-3mw4q7m3 154 15 in in IN cord-323404-3mw4q7m3 154 16 HIV-1 HIV-1 NNP cord-323404-3mw4q7m3 154 17 gp120 gp120 NNP cord-323404-3mw4q7m3 154 18 , , , cord-323404-3mw4q7m3 154 19 is be VBZ cord-323404-3mw4q7m3 154 20 also also RB cord-323404-3mw4q7m3 154 21 found find VBN cord-323404-3mw4q7m3 154 22 on on IN cord-323404-3mw4q7m3 154 23 prion prion NN cord-323404-3mw4q7m3 154 24 protein protein NN cord-323404-3mw4q7m3 154 25 and and CC cord-323404-3mw4q7m3 154 26 the the DT cord-323404-3mw4q7m3 154 27 amyloid amyloid NN cord-323404-3mw4q7m3 154 28 - - HYPH cord-323404-3mw4q7m3 154 29 β β NN cord-323404-3mw4q7m3 154 30 peptide peptide NN cord-323404-3mw4q7m3 155 1 that that DT cord-323404-3mw4q7m3 155 2 is be VBZ cord-323404-3mw4q7m3 155 3 involved involve VBN cord-323404-3mw4q7m3 155 4 in in IN cord-323404-3mw4q7m3 155 5 Alzheimer Alzheimer NNP cord-323404-3mw4q7m3 155 6 's 's POS cord-323404-3mw4q7m3 155 7 disease disease NN cord-323404-3mw4q7m3 155 8 60 60 CD cord-323404-3mw4q7m3 155 9 . . . cord-323404-3mw4q7m3 156 1 Proteoglycans proteoglycan NNS cord-323404-3mw4q7m3 156 2 . . . cord-323404-3mw4q7m3 157 1 Another another DT cord-323404-3mw4q7m3 157 2 class class NN cord-323404-3mw4q7m3 157 3 of of IN cord-323404-3mw4q7m3 157 4 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 157 5 attachment attachment NN cord-323404-3mw4q7m3 157 6 receptors receptor NNS cord-323404-3mw4q7m3 157 7 used use VBN cord-323404-3mw4q7m3 157 8 by by IN cord-323404-3mw4q7m3 157 9 viruses virus NNS cord-323404-3mw4q7m3 157 10 are be VBP cord-323404-3mw4q7m3 157 11 found find VBN cord-323404-3mw4q7m3 157 12 on on IN cord-323404-3mw4q7m3 157 13 proteoglycans proteoglycan NNS cord-323404-3mw4q7m3 157 14 . . . cord-323404-3mw4q7m3 158 1 Proteoglycans proteoglycan NNS cord-323404-3mw4q7m3 158 2 are be VBP cord-323404-3mw4q7m3 158 3 proteins protein NNS cord-323404-3mw4q7m3 158 4 that that WDT cord-323404-3mw4q7m3 158 5 are be VBP cord-323404-3mw4q7m3 158 6 classified classify VBN cord-323404-3mw4q7m3 158 7 by by IN cord-323404-3mw4q7m3 158 8 the the DT cord-323404-3mw4q7m3 158 9 post post JJ cord-323404-3mw4q7m3 158 10 - - JJ cord-323404-3mw4q7m3 158 11 translational translational JJ cord-323404-3mw4q7m3 158 12 attachment attachment NN cord-323404-3mw4q7m3 158 13 of of IN cord-323404-3mw4q7m3 158 14 polysaccharide polysaccharide NN cord-323404-3mw4q7m3 158 15 GLYCOSAMINOGLYCAN GLYCOSAMINOGLYCAN NNP cord-323404-3mw4q7m3 158 16 moieties moiety NNS cord-323404-3mw4q7m3 158 17 ( ( -LRB- cord-323404-3mw4q7m3 158 18 FIG FIG NNP cord-323404-3mw4q7m3 158 19 . . . cord-323404-3mw4q7m3 158 20 1 1 CD cord-323404-3mw4q7m3 158 21 ) ) -RRB- cord-323404-3mw4q7m3 158 22 . . . cord-323404-3mw4q7m3 159 1 Glycosaminoglycan glycosaminoglycan JJ cord-323404-3mw4q7m3 159 2 chains chain NNS cord-323404-3mw4q7m3 159 3 provide provide VBP cord-323404-3mw4q7m3 159 4 the the DT cord-323404-3mw4q7m3 159 5 initial initial JJ cord-323404-3mw4q7m3 159 6 docking docking NN cord-323404-3mw4q7m3 159 7 sites site NNS cord-323404-3mw4q7m3 159 8 for for IN cord-323404-3mw4q7m3 159 9 viruses virus NNS cord-323404-3mw4q7m3 159 10 to to TO cord-323404-3mw4q7m3 159 11 bind bind VB cord-323404-3mw4q7m3 159 12 to to IN cord-323404-3mw4q7m3 159 13 eukaryotic eukaryotic JJ cord-323404-3mw4q7m3 159 14 cells cell NNS cord-323404-3mw4q7m3 159 15 . . . cord-323404-3mw4q7m3 160 1 The the DT cord-323404-3mw4q7m3 160 2 ubiquitously ubiquitously RB cord-323404-3mw4q7m3 160 3 expressed express VBN cord-323404-3mw4q7m3 160 4 glycosaminoglycan glycosaminoglycan NNP cord-323404-3mw4q7m3 160 5 HEPARAN HEPARAN NNP cord-323404-3mw4q7m3 160 6 SULPHATE SULPHATE NNP cord-323404-3mw4q7m3 160 7 is be VBZ cord-323404-3mw4q7m3 160 8 highly highly RB cord-323404-3mw4q7m3 160 9 polymorphic polymorphic JJ cord-323404-3mw4q7m3 160 10 , , , cord-323404-3mw4q7m3 160 11 and and CC cord-323404-3mw4q7m3 160 12 its -PRON- PRP$ cord-323404-3mw4q7m3 160 13 sulphated sulphated JJ cord-323404-3mw4q7m3 160 14 structural structural JJ cord-323404-3mw4q7m3 160 15 motifs motif NNS cord-323404-3mw4q7m3 160 16 are be VBP cord-323404-3mw4q7m3 160 17 responsible responsible JJ cord-323404-3mw4q7m3 160 18 primarily primarily RB cord-323404-3mw4q7m3 160 19 for for IN cord-323404-3mw4q7m3 160 20 its -PRON- PRP$ cord-323404-3mw4q7m3 160 21 protein protein NN cord-323404-3mw4q7m3 160 22 binding binding NN cord-323404-3mw4q7m3 160 23 and and CC cord-323404-3mw4q7m3 160 24 regulatory regulatory JJ cord-323404-3mw4q7m3 160 25 properties property NNS cord-323404-3mw4q7m3 160 26 , , , cord-323404-3mw4q7m3 160 27 as as IN cord-323404-3mw4q7m3 160 28 shown show VBN cord-323404-3mw4q7m3 160 29 recently recently RB cord-323404-3mw4q7m3 160 30 61 61 CD cord-323404-3mw4q7m3 160 31 for for IN cord-323404-3mw4q7m3 160 32 respiratory respiratory JJ cord-323404-3mw4q7m3 160 33 syncytial syncytial JJ cord-323404-3mw4q7m3 160 34 virus virus NN cord-323404-3mw4q7m3 160 35 ( ( -LRB- cord-323404-3mw4q7m3 160 36 RSV RSV NNP cord-323404-3mw4q7m3 160 37 ) ) -RRB- cord-323404-3mw4q7m3 160 38 . . . cord-323404-3mw4q7m3 161 1 During during IN cord-323404-3mw4q7m3 161 2 the the DT cord-323404-3mw4q7m3 161 3 past past JJ cord-323404-3mw4q7m3 161 4 decade decade NN cord-323404-3mw4q7m3 161 5 , , , cord-323404-3mw4q7m3 161 6 proteoglycans proteoglycan NNS cord-323404-3mw4q7m3 161 7 have have VBP cord-323404-3mw4q7m3 161 8 emerged emerge VBN cord-323404-3mw4q7m3 161 9 as as IN cord-323404-3mw4q7m3 161 10 key key JJ cord-323404-3mw4q7m3 161 11 players player NNS cord-323404-3mw4q7m3 161 12 in in IN cord-323404-3mw4q7m3 161 13 the the DT cord-323404-3mw4q7m3 161 14 regulatory regulatory JJ cord-323404-3mw4q7m3 161 15 network network NN cord-323404-3mw4q7m3 161 16 of of IN cord-323404-3mw4q7m3 161 17 the the DT cord-323404-3mw4q7m3 161 18 cell cell NN cord-323404-3mw4q7m3 161 19 62 62 CD cord-323404-3mw4q7m3 161 20 . . . cord-323404-3mw4q7m3 162 1 Depending depend VBG cord-323404-3mw4q7m3 162 2 on on IN cord-323404-3mw4q7m3 162 3 the the DT cord-323404-3mw4q7m3 162 4 length length NN cord-323404-3mw4q7m3 162 5 of of IN cord-323404-3mw4q7m3 162 6 the the DT cord-323404-3mw4q7m3 162 7 glycosaminoglycan glycosaminoglycan JJ cord-323404-3mw4q7m3 162 8 chain chain NN cord-323404-3mw4q7m3 162 9 , , , cord-323404-3mw4q7m3 162 10 and and CC cord-323404-3mw4q7m3 162 11 on on IN cord-323404-3mw4q7m3 162 12 the the DT cord-323404-3mw4q7m3 162 13 sulphated sulphated JJ cord-323404-3mw4q7m3 162 14 structural structural JJ cord-323404-3mw4q7m3 162 15 motifs motif NNS cord-323404-3mw4q7m3 162 16 , , , cord-323404-3mw4q7m3 162 17 a a DT cord-323404-3mw4q7m3 162 18 single single JJ cord-323404-3mw4q7m3 162 19 glycosaminoglycan glycosaminoglycan JJ cord-323404-3mw4q7m3 162 20 chain chain NN cord-323404-3mw4q7m3 162 21 can can MD cord-323404-3mw4q7m3 162 22 bind bind VB cord-323404-3mw4q7m3 162 23 many many JJ cord-323404-3mw4q7m3 162 24 viral viral JJ cord-323404-3mw4q7m3 162 25 ligands ligand NNS cord-323404-3mw4q7m3 162 26 on on IN cord-323404-3mw4q7m3 162 27 a a DT cord-323404-3mw4q7m3 162 28 single single JJ cord-323404-3mw4q7m3 162 29 virion virion NN cord-323404-3mw4q7m3 162 30 62 62 CD cord-323404-3mw4q7m3 162 31 . . . cord-323404-3mw4q7m3 163 1 As as IN cord-323404-3mw4q7m3 163 2 the the DT cord-323404-3mw4q7m3 163 3 cell cell NN cord-323404-3mw4q7m3 163 4 attachment attachment NN cord-323404-3mw4q7m3 163 5 receptors receptor NNS cord-323404-3mw4q7m3 163 6 for for IN cord-323404-3mw4q7m3 163 7 numerous numerous JJ cord-323404-3mw4q7m3 163 8 enveloped envelop VBN cord-323404-3mw4q7m3 163 9 and and CC cord-323404-3mw4q7m3 163 10 naked naked JJ cord-323404-3mw4q7m3 163 11 viruses virus NNS cord-323404-3mw4q7m3 163 12 , , , cord-323404-3mw4q7m3 163 13 the the DT cord-323404-3mw4q7m3 163 14 glycosyl glycosyl JJ cord-323404-3mw4q7m3 163 15 epitopes epitope NNS cord-323404-3mw4q7m3 163 16 of of IN cord-323404-3mw4q7m3 163 17 the the DT cord-323404-3mw4q7m3 163 18 epithelial epithelial JJ cord-323404-3mw4q7m3 163 19 - - HYPH cord-323404-3mw4q7m3 163 20 cell cell NN cord-323404-3mw4q7m3 163 21 - - HYPH cord-323404-3mw4q7m3 163 22 surface surface NN cord-323404-3mw4q7m3 163 23 proteoglycans proteoglycan NNS cord-323404-3mw4q7m3 163 24 mediate mediate VBP cord-323404-3mw4q7m3 163 25 virus virus NN cord-323404-3mw4q7m3 163 26 adhesion adhesion NN cord-323404-3mw4q7m3 163 27 , , , cord-323404-3mw4q7m3 163 28 in in IN cord-323404-3mw4q7m3 163 29 turn turn NN cord-323404-3mw4q7m3 163 30 initiating initiate VBG cord-323404-3mw4q7m3 163 31 signal signal NN cord-323404-3mw4q7m3 163 32 transduction transduction NN cord-323404-3mw4q7m3 163 33 as as IN cord-323404-3mw4q7m3 163 34 described describe VBN cord-323404-3mw4q7m3 163 35 for for IN cord-323404-3mw4q7m3 163 36 the the DT cord-323404-3mw4q7m3 163 37 GLYCOSYNAPSE GLYCOSYNAPSE NNP cord-323404-3mw4q7m3 163 38 54 54 CD cord-323404-3mw4q7m3 163 39 . . . cord-323404-3mw4q7m3 164 1 HSV-1 hsv-1 NN cord-323404-3mw4q7m3 164 2 uses use VBZ cord-323404-3mw4q7m3 164 3 glycosaminoglycan glycosaminoglycan NNP cord-323404-3mw4q7m3 164 4 as as IN cord-323404-3mw4q7m3 164 5 a a DT cord-323404-3mw4q7m3 164 6 receptor receptor NN cord-323404-3mw4q7m3 164 7 for for IN cord-323404-3mw4q7m3 164 8 entry entry NN cord-323404-3mw4q7m3 164 9 into into IN cord-323404-3mw4q7m3 164 10 epithelial epithelial JJ cord-323404-3mw4q7m3 164 11 cells cell NNS cord-323404-3mw4q7m3 164 12 as as RB cord-323404-3mw4q7m3 164 13 well well RB cord-323404-3mw4q7m3 164 14 as as IN cord-323404-3mw4q7m3 164 15 into into IN cord-323404-3mw4q7m3 164 16 primary primary JJ cord-323404-3mw4q7m3 164 17 neuronal neuronal JJ cord-323404-3mw4q7m3 164 18 cells cell NNS cord-323404-3mw4q7m3 164 19 . . . cord-323404-3mw4q7m3 165 1 There there EX cord-323404-3mw4q7m3 165 2 are be VBP cord-323404-3mw4q7m3 165 3 five five CD cord-323404-3mw4q7m3 165 4 HSV-1 hsv-1 NN cord-323404-3mw4q7m3 165 5 glycoproteins glycoprotein NNS cord-323404-3mw4q7m3 165 6 -gB -gb XX cord-323404-3mw4q7m3 165 7 , , , cord-323404-3mw4q7m3 165 8 gC gC NNP cord-323404-3mw4q7m3 165 9 , , , cord-323404-3mw4q7m3 165 10 gD gD NNP cord-323404-3mw4q7m3 165 11 , , , cord-323404-3mw4q7m3 165 12 gH gh NN cord-323404-3mw4q7m3 165 13 and and CC cord-323404-3mw4q7m3 165 14 gL gl NN cord-323404-3mw4q7m3 166 1 -and -and : cord-323404-3mw4q7m3 166 2 two two CD cord-323404-3mw4q7m3 166 3 of of IN cord-323404-3mw4q7m3 166 4 these these DT cord-323404-3mw4q7m3 166 5 ( ( -LRB- cord-323404-3mw4q7m3 166 6 gB gB NNP cord-323404-3mw4q7m3 166 7 and and CC cord-323404-3mw4q7m3 166 8 gC gC NNP cord-323404-3mw4q7m3 166 9 ) ) -RRB- cord-323404-3mw4q7m3 166 10 mediate mediate VB cord-323404-3mw4q7m3 166 11 the the DT cord-323404-3mw4q7m3 166 12 attachment attachment NN cord-323404-3mw4q7m3 166 13 of of IN cord-323404-3mw4q7m3 166 14 the the DT cord-323404-3mw4q7m3 166 15 virus virus NN cord-323404-3mw4q7m3 166 16 to to IN cord-323404-3mw4q7m3 166 17 cellular cellular JJ cord-323404-3mw4q7m3 166 18 heparan heparan NN cord-323404-3mw4q7m3 166 19 sulphate sulphate NN cord-323404-3mw4q7m3 166 20 47 47 CD cord-323404-3mw4q7m3 166 21 , , , cord-323404-3mw4q7m3 166 22 63 63 CD cord-323404-3mw4q7m3 166 23 . . . cord-323404-3mw4q7m3 167 1 Human human JJ cord-323404-3mw4q7m3 167 2 herpesvirus herpesvirus NN cord-323404-3mw4q7m3 167 3 8 8 CD cord-323404-3mw4q7m3 167 4 ( ( -LRB- cord-323404-3mw4q7m3 167 5 HHV-8 HHV-8 NNP cord-323404-3mw4q7m3 167 6 ) ) -RRB- cord-323404-3mw4q7m3 167 7 , , , cord-323404-3mw4q7m3 167 8 which which WDT cord-323404-3mw4q7m3 167 9 is be VBZ cord-323404-3mw4q7m3 167 10 associated associate VBN cord-323404-3mw4q7m3 167 11 with with IN cord-323404-3mw4q7m3 167 12 Kaposi Kaposi NNP cord-323404-3mw4q7m3 167 13 's 's POS cord-323404-3mw4q7m3 167 14 sarcoma sarcoma NN cord-323404-3mw4q7m3 167 15 , , , cord-323404-3mw4q7m3 167 16 has have VBZ cord-323404-3mw4q7m3 167 17 a a DT cord-323404-3mw4q7m3 167 18 broad broad JJ cord-323404-3mw4q7m3 167 19 cellular cellular JJ cord-323404-3mw4q7m3 167 20 tropism tropism NN cord-323404-3mw4q7m3 167 21 that that WDT cord-323404-3mw4q7m3 167 22 includes include VBZ cord-323404-3mw4q7m3 167 23 epithelial epithelial JJ cord-323404-3mw4q7m3 167 24 cells cell NNS cord-323404-3mw4q7m3 167 25 . . . cord-323404-3mw4q7m3 168 1 This this DT cord-323404-3mw4q7m3 168 2 broad broad JJ cord-323404-3mw4q7m3 168 3 tropism tropism NN cord-323404-3mw4q7m3 168 4 might may MD cord-323404-3mw4q7m3 168 5 be be VB cord-323404-3mw4q7m3 168 6 due due JJ cord-323404-3mw4q7m3 168 7 , , , cord-323404-3mw4q7m3 168 8 at at IN cord-323404-3mw4q7m3 168 9 least least JJS cord-323404-3mw4q7m3 168 10 in in IN cord-323404-3mw4q7m3 168 11 part part NN cord-323404-3mw4q7m3 168 12 , , , cord-323404-3mw4q7m3 168 13 to to IN cord-323404-3mw4q7m3 168 14 interaction interaction NN cord-323404-3mw4q7m3 168 15 of of IN cord-323404-3mw4q7m3 168 16 the the DT cord-323404-3mw4q7m3 168 17 viral viral JJ cord-323404-3mw4q7m3 168 18 surface surface NN cord-323404-3mw4q7m3 168 19 glycoproteins glycoprotein NNS cord-323404-3mw4q7m3 168 20 with with IN cord-323404-3mw4q7m3 168 21 heparan heparan NN cord-323404-3mw4q7m3 168 22 sulphate sulphate NN cord-323404-3mw4q7m3 168 23 64 64 CD cord-323404-3mw4q7m3 168 24 . . . cord-323404-3mw4q7m3 169 1 Enveloped Enveloped NNP cord-323404-3mw4q7m3 169 2 Rous rous JJ cord-323404-3mw4q7m3 169 3 sarcoma sarcoma NN cord-323404-3mw4q7m3 169 4 virus virus NN cord-323404-3mw4q7m3 169 5 ( ( -LRB- cord-323404-3mw4q7m3 169 6 RSV RSV NNP cord-323404-3mw4q7m3 169 7 ) ) -RRB- cord-323404-3mw4q7m3 169 8 65 65 CD cord-323404-3mw4q7m3 169 9 and and CC cord-323404-3mw4q7m3 169 10 adenovirus-2 adenovirus-2 NNP cord-323404-3mw4q7m3 170 1 and and CC cord-323404-3mw4q7m3 170 2 -5 -5 NNP cord-323404-3mw4q7m3 170 3 ( ( -LRB- cord-323404-3mw4q7m3 170 4 REF ref NN cord-323404-3mw4q7m3 170 5 . . . cord-323404-3mw4q7m3 170 6 66 66 CD cord-323404-3mw4q7m3 170 7 ) ) -RRB- cord-323404-3mw4q7m3 170 8 , , , cord-323404-3mw4q7m3 170 9 as as RB cord-323404-3mw4q7m3 170 10 well well RB cord-323404-3mw4q7m3 170 11 as as IN cord-323404-3mw4q7m3 170 12 several several JJ cord-323404-3mw4q7m3 170 13 naked naked JJ cord-323404-3mw4q7m3 170 14 viruses virus NNS cord-323404-3mw4q7m3 170 15 including include VBG cord-323404-3mw4q7m3 170 16 echovirus echovirus NNP cord-323404-3mw4q7m3 170 17 , , , cord-323404-3mw4q7m3 170 18 AAV-2 AAV-2 NNP cord-323404-3mw4q7m3 170 19 , , , cord-323404-3mw4q7m3 170 20 human human JJ cord-323404-3mw4q7m3 170 21 papilloma papilloma NN cord-323404-3mw4q7m3 170 22 virus virus NN cord-323404-3mw4q7m3 170 23 ( ( -LRB- cord-323404-3mw4q7m3 170 24 HPV)-16 HPV)-16 NNP cord-323404-3mw4q7m3 170 25 , , , cord-323404-3mw4q7m3 170 26 HPV-33 HPV-33 NNP cord-323404-3mw4q7m3 170 27 and and CC cord-323404-3mw4q7m3 170 28 FMDV FMDV NNP cord-323404-3mw4q7m3 171 1 ( ( -LRB- cord-323404-3mw4q7m3 171 2 REFS REFS NNP cord-323404-3mw4q7m3 171 3 30 30 CD cord-323404-3mw4q7m3 171 4 , , , cord-323404-3mw4q7m3 171 5 40 40 CD cord-323404-3mw4q7m3 171 6 , , , cord-323404-3mw4q7m3 171 7 ( ( -LRB- cord-323404-3mw4q7m3 171 8 67 67 CD cord-323404-3mw4q7m3 171 9 ) ) -RRB- cord-323404-3mw4q7m3 171 10 ( ( -LRB- cord-323404-3mw4q7m3 171 11 68 68 CD cord-323404-3mw4q7m3 171 12 ) ) -RRB- cord-323404-3mw4q7m3 171 13 ( ( -LRB- cord-323404-3mw4q7m3 171 14 69 69 CD cord-323404-3mw4q7m3 171 15 ) ) -RRB- cord-323404-3mw4q7m3 171 16 ( ( -LRB- cord-323404-3mw4q7m3 171 17 70 70 CD cord-323404-3mw4q7m3 171 18 ) ) -RRB- cord-323404-3mw4q7m3 171 19 , , , cord-323404-3mw4q7m3 171 20 interact interact VBP cord-323404-3mw4q7m3 171 21 with with IN cord-323404-3mw4q7m3 171 22 heparan heparan JJ cord-323404-3mw4q7m3 171 23 sulphate sulphate NN cord-323404-3mw4q7m3 171 24 proteoglycans proteoglycan NNS cord-323404-3mw4q7m3 171 25 , , , cord-323404-3mw4q7m3 171 26 which which WDT cord-323404-3mw4q7m3 171 27 facilitates facilitate VBZ cord-323404-3mw4q7m3 171 28 the the DT cord-323404-3mw4q7m3 171 29 attachment attachment NN cord-323404-3mw4q7m3 171 30 and and CC cord-323404-3mw4q7m3 171 31 infectivity infectivity NN cord-323404-3mw4q7m3 171 32 of of IN cord-323404-3mw4q7m3 171 33 the the DT cord-323404-3mw4q7m3 171 34 virus virus NN cord-323404-3mw4q7m3 171 35 . . . cord-323404-3mw4q7m3 172 1 The the DT cord-323404-3mw4q7m3 172 2 use use NN cord-323404-3mw4q7m3 172 3 of of IN cord-323404-3mw4q7m3 172 4 heparan heparan NN cord-323404-3mw4q7m3 172 5 sulphate sulphate NN cord-323404-3mw4q7m3 172 6 as as IN cord-323404-3mw4q7m3 172 7 an an DT cord-323404-3mw4q7m3 172 8 alternative alternative JJ cord-323404-3mw4q7m3 172 9 receptor receptor NN cord-323404-3mw4q7m3 172 10 is be VBZ cord-323404-3mw4q7m3 172 11 likely likely JJ cord-323404-3mw4q7m3 172 12 to to TO cord-323404-3mw4q7m3 172 13 be be VB cord-323404-3mw4q7m3 172 14 the the DT cord-323404-3mw4q7m3 172 15 result result NN cord-323404-3mw4q7m3 172 16 of of IN cord-323404-3mw4q7m3 172 17 an an DT cord-323404-3mw4q7m3 172 18 adaptation adaptation NN cord-323404-3mw4q7m3 172 19 to to IN cord-323404-3mw4q7m3 172 20 growth growth NN cord-323404-3mw4q7m3 172 21 in in IN cord-323404-3mw4q7m3 172 22 cell cell NN cord-323404-3mw4q7m3 172 23 lines line NNS cord-323404-3mw4q7m3 172 24 71 71 CD cord-323404-3mw4q7m3 172 25 . . . cord-323404-3mw4q7m3 173 1 Paradoxically paradoxically RB cord-323404-3mw4q7m3 173 2 , , , cord-323404-3mw4q7m3 173 3 the the DT cord-323404-3mw4q7m3 173 4 binding binding NN cord-323404-3mw4q7m3 173 5 of of IN cord-323404-3mw4q7m3 173 6 a a DT cord-323404-3mw4q7m3 173 7 virus virus NN cord-323404-3mw4q7m3 173 8 to to IN cord-323404-3mw4q7m3 173 9 heparan heparan NN cord-323404-3mw4q7m3 173 10 sulphate sulphate NN cord-323404-3mw4q7m3 173 11 might may MD cord-323404-3mw4q7m3 173 12 prevent prevent VB cord-323404-3mw4q7m3 173 13 the the DT cord-323404-3mw4q7m3 173 14 virus virus NN cord-323404-3mw4q7m3 173 15 from from IN cord-323404-3mw4q7m3 173 16 reaching reach VBG cord-323404-3mw4q7m3 173 17 the the DT cord-323404-3mw4q7m3 173 18 cell cell NN cord-323404-3mw4q7m3 173 19 surface surface NN cord-323404-3mw4q7m3 173 20 . . . cord-323404-3mw4q7m3 174 1 Indeed indeed RB cord-323404-3mw4q7m3 174 2 , , , cord-323404-3mw4q7m3 174 3 heparan heparan JJ cord-323404-3mw4q7m3 174 4 sulphates sulphate NNS cord-323404-3mw4q7m3 174 5 are be VBP cord-323404-3mw4q7m3 174 6 present present JJ cord-323404-3mw4q7m3 174 7 in in IN cord-323404-3mw4q7m3 174 8 proteoglycans proteoglycan NNS cord-323404-3mw4q7m3 174 9 in in IN cord-323404-3mw4q7m3 174 10 the the DT cord-323404-3mw4q7m3 174 11 extracellular extracellular JJ cord-323404-3mw4q7m3 174 12 matrix matrix NN cord-323404-3mw4q7m3 174 13 , , , cord-323404-3mw4q7m3 174 14 and and CC cord-323404-3mw4q7m3 174 15 these these DT cord-323404-3mw4q7m3 174 16 noncellular noncellular JJ cord-323404-3mw4q7m3 174 17 matrix matrix NN cord-323404-3mw4q7m3 174 18 structures structure NNS cord-323404-3mw4q7m3 174 19 can can MD cord-323404-3mw4q7m3 174 20 bind bind VB cord-323404-3mw4q7m3 174 21 viruses virus NNS cord-323404-3mw4q7m3 174 22 . . . cord-323404-3mw4q7m3 175 1 The the DT cord-323404-3mw4q7m3 175 2 basal basal NN cord-323404-3mw4q7m3 175 3 lamina lamina NN cord-323404-3mw4q7m3 175 4 , , , cord-323404-3mw4q7m3 175 5 for for IN cord-323404-3mw4q7m3 175 6 example example NN cord-323404-3mw4q7m3 175 7 , , , cord-323404-3mw4q7m3 175 8 is be VBZ cord-323404-3mw4q7m3 175 9 a a DT cord-323404-3mw4q7m3 175 10 barrier barrier NN cord-323404-3mw4q7m3 175 11 to to IN cord-323404-3mw4q7m3 175 12 the the DT cord-323404-3mw4q7m3 175 13 spread spread NN cord-323404-3mw4q7m3 175 14 of of IN cord-323404-3mw4q7m3 175 15 HSV-1 hsv-1 NN cord-323404-3mw4q7m3 175 16 from from IN cord-323404-3mw4q7m3 175 17 , , , cord-323404-3mw4q7m3 175 18 and and CC cord-323404-3mw4q7m3 175 19 back back RB cord-323404-3mw4q7m3 175 20 into into IN cord-323404-3mw4q7m3 175 21 , , , cord-323404-3mw4q7m3 175 22 epithelial epithelial JJ cord-323404-3mw4q7m3 175 23 cells cell NNS cord-323404-3mw4q7m3 175 24 . . . cord-323404-3mw4q7m3 176 1 In in IN cord-323404-3mw4q7m3 176 2 addition addition NN cord-323404-3mw4q7m3 176 3 , , , cord-323404-3mw4q7m3 176 4 certain certain JJ cord-323404-3mw4q7m3 176 5 bodily bodily JJ cord-323404-3mw4q7m3 176 6 fluids fluid NNS cord-323404-3mw4q7m3 176 7 contain contain VBP cord-323404-3mw4q7m3 176 8 heparin heparin NN cord-323404-3mw4q7m3 176 9 , , , cord-323404-3mw4q7m3 176 10 heparan heparan NN cord-323404-3mw4q7m3 176 11 sulphate sulphate NN cord-323404-3mw4q7m3 176 12 and and CC cord-323404-3mw4q7m3 176 13 heparin heparin NN cord-323404-3mw4q7m3 176 14 - - HYPH cord-323404-3mw4q7m3 176 15 binding bind VBG cord-323404-3mw4q7m3 176 16 proteins protein NNS cord-323404-3mw4q7m3 176 17 , , , cord-323404-3mw4q7m3 176 18 all all DT cord-323404-3mw4q7m3 176 19 of of IN cord-323404-3mw4q7m3 176 20 which which WDT cord-323404-3mw4q7m3 176 21 can can MD cord-323404-3mw4q7m3 176 22 compete compete VB cord-323404-3mw4q7m3 176 23 with with IN cord-323404-3mw4q7m3 176 24 and and CC cord-323404-3mw4q7m3 176 25 inhibit inhibit VB cord-323404-3mw4q7m3 176 26 the the DT cord-323404-3mw4q7m3 176 27 binding binding NN cord-323404-3mw4q7m3 176 28 of of IN cord-323404-3mw4q7m3 176 29 viruses virus NNS cord-323404-3mw4q7m3 176 30 to to IN cord-323404-3mw4q7m3 176 31 cell cell NN cord-323404-3mw4q7m3 176 32 - - HYPH cord-323404-3mw4q7m3 176 33 surface surface NN cord-323404-3mw4q7m3 176 34 heparan heparan NN cord-323404-3mw4q7m3 176 35 sulphate sulphate NN cord-323404-3mw4q7m3 176 36 72 72 CD cord-323404-3mw4q7m3 176 37 . . . cord-323404-3mw4q7m3 177 1 through through IN cord-323404-3mw4q7m3 177 2 sialyloligosaccharides sialyloligosaccharide NNS cord-323404-3mw4q7m3 177 3 , , , cord-323404-3mw4q7m3 177 4 which which WDT cord-323404-3mw4q7m3 177 5 are be VBP cord-323404-3mw4q7m3 177 6 either either CC cord-323404-3mw4q7m3 177 7 from from IN cord-323404-3mw4q7m3 177 8 glycosphingolipids glycosphingolipid NNS cord-323404-3mw4q7m3 177 9 51 51 CD cord-323404-3mw4q7m3 177 10 or or CC cord-323404-3mw4q7m3 177 11 proteoglycans proteoglycan NNS cord-323404-3mw4q7m3 177 12 52 52 CD cord-323404-3mw4q7m3 177 13 . . . cord-323404-3mw4q7m3 178 1 Glycosphingolipids glycosphingolipid NNS cord-323404-3mw4q7m3 178 2 . . . cord-323404-3mw4q7m3 179 1 Several several JJ cord-323404-3mw4q7m3 179 2 enveloped envelop VBN cord-323404-3mw4q7m3 179 3 and and CC cord-323404-3mw4q7m3 179 4 naked naked JJ cord-323404-3mw4q7m3 179 5 viruses virus NNS cord-323404-3mw4q7m3 179 6 have have VBP cord-323404-3mw4q7m3 179 7 recently recently RB cord-323404-3mw4q7m3 179 8 been be VBN cord-323404-3mw4q7m3 179 9 shown show VBN cord-323404-3mw4q7m3 179 10 to to TO cord-323404-3mw4q7m3 179 11 interact interact VB cord-323404-3mw4q7m3 179 12 specifically specifically RB cord-323404-3mw4q7m3 179 13 with with IN cord-323404-3mw4q7m3 179 14 a a DT cord-323404-3mw4q7m3 179 15 defined define VBN cord-323404-3mw4q7m3 179 16 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 179 17 moiety moiety NN cord-323404-3mw4q7m3 179 18 of of IN cord-323404-3mw4q7m3 179 19 glycosphingolipids glycosphingolipid NNS cord-323404-3mw4q7m3 179 20 ( ( -LRB- cord-323404-3mw4q7m3 179 21 FIG FIG NNP cord-323404-3mw4q7m3 179 22 . . . cord-323404-3mw4q7m3 179 23 1 1 CD cord-323404-3mw4q7m3 179 24 ; ; : cord-323404-3mw4q7m3 179 25 TABLE table NN cord-323404-3mw4q7m3 179 26 1 1 CD cord-323404-3mw4q7m3 179 27 ) ) -RRB- cord-323404-3mw4q7m3 179 28 . . . cord-323404-3mw4q7m3 180 1 Glycosphingolipids glycosphingolipid NNS cord-323404-3mw4q7m3 180 2 -which -which NNP cord-323404-3mw4q7m3 180 3 are be VBP cord-323404-3mw4q7m3 180 4 characteristic characteristic JJ cord-323404-3mw4q7m3 180 5 components component NNS cord-323404-3mw4q7m3 180 6 of of IN cord-323404-3mw4q7m3 180 7 eukaryotic eukaryotic JJ cord-323404-3mw4q7m3 180 8 plasma plasma NN cord-323404-3mw4q7m3 180 9 membranes membrane NNS cord-323404-3mw4q7m3 180 10 -are -are : cord-323404-3mw4q7m3 180 11 a a DT cord-323404-3mw4q7m3 180 12 highly highly RB cord-323404-3mw4q7m3 180 13 polymorphic polymorphic JJ cord-323404-3mw4q7m3 180 14 class class NN cord-323404-3mw4q7m3 180 15 of of IN cord-323404-3mw4q7m3 180 16 lipids lipid NNS cord-323404-3mw4q7m3 180 17 and and CC cord-323404-3mw4q7m3 180 18 are be VBP cord-323404-3mw4q7m3 180 19 principal principal JJ cord-323404-3mw4q7m3 180 20 components component NNS cord-323404-3mw4q7m3 180 21 of of IN cord-323404-3mw4q7m3 180 22 the the DT cord-323404-3mw4q7m3 180 23 apical apical JJ cord-323404-3mw4q7m3 180 24 plasma plasma NN cord-323404-3mw4q7m3 180 25 membrane membrane NN cord-323404-3mw4q7m3 180 26 of of IN cord-323404-3mw4q7m3 180 27 epithelial epithelial JJ cord-323404-3mw4q7m3 180 28 cells cell NNS cord-323404-3mw4q7m3 180 29 in in IN cord-323404-3mw4q7m3 180 30 the the DT cord-323404-3mw4q7m3 180 31 gastrointestinal gastrointestinal JJ cord-323404-3mw4q7m3 180 32 and and CC cord-323404-3mw4q7m3 180 33 urinary urinary JJ cord-323404-3mw4q7m3 180 34 tracts tract NNS cord-323404-3mw4q7m3 180 35 , , , cord-323404-3mw4q7m3 180 36 myelin myelin NN cord-323404-3mw4q7m3 180 37 and and CC cord-323404-3mw4q7m3 180 38 neuroepithelial neuroepithelial JJ cord-323404-3mw4q7m3 180 39 cells cell NNS cord-323404-3mw4q7m3 180 40 53 53 CD cord-323404-3mw4q7m3 180 41 . . . cord-323404-3mw4q7m3 181 1 Glycosphingolipids glycosphingolipid NNS cord-323404-3mw4q7m3 181 2 are be VBP cord-323404-3mw4q7m3 181 3 anchored anchor VBN cord-323404-3mw4q7m3 181 4 in in IN cord-323404-3mw4q7m3 181 5 the the DT cord-323404-3mw4q7m3 181 6 outer outer JJ cord-323404-3mw4q7m3 181 7 leaflet leaflet NN cord-323404-3mw4q7m3 181 8 of of IN cord-323404-3mw4q7m3 181 9 the the DT cord-323404-3mw4q7m3 181 10 plasma plasma NN cord-323404-3mw4q7m3 181 11 membrane membrane NN cord-323404-3mw4q7m3 181 12 bilayer bilayer NN cord-323404-3mw4q7m3 181 13 by by IN cord-323404-3mw4q7m3 181 14 their -PRON- PRP$ cord-323404-3mw4q7m3 181 15 common common JJ cord-323404-3mw4q7m3 181 16 hydrophobic hydrophobic JJ cord-323404-3mw4q7m3 181 17 backbone backbone NN cord-323404-3mw4q7m3 181 18 , , , cord-323404-3mw4q7m3 181 19 ceramide ceramide NN cord-323404-3mw4q7m3 181 20 , , , cord-323404-3mw4q7m3 181 21 which which WDT cord-323404-3mw4q7m3 181 22 consists consist VBZ cord-323404-3mw4q7m3 181 23 of of IN cord-323404-3mw4q7m3 181 24 a a DT cord-323404-3mw4q7m3 181 25 fatty fatty JJ cord-323404-3mw4q7m3 181 26 - - HYPH cord-323404-3mw4q7m3 181 27 acid acid NN cord-323404-3mw4q7m3 181 28 chain chain NN cord-323404-3mw4q7m3 181 29 that that WDT cord-323404-3mw4q7m3 181 30 is be VBZ cord-323404-3mw4q7m3 181 31 linked link VBN cord-323404-3mw4q7m3 181 32 to to IN cord-323404-3mw4q7m3 181 33 the the DT cord-323404-3mw4q7m3 181 34 sphingosine sphingosine JJ cord-323404-3mw4q7m3 181 35 base base NN cord-323404-3mw4q7m3 181 36 . . . cord-323404-3mw4q7m3 182 1 The the DT cord-323404-3mw4q7m3 182 2 hydrophilic hydrophilic JJ cord-323404-3mw4q7m3 182 3 oligosaccharide oligosaccharide NN cord-323404-3mw4q7m3 182 4 residues residue NNS cord-323404-3mw4q7m3 182 5 of of IN cord-323404-3mw4q7m3 182 6 neutral neutral JJ cord-323404-3mw4q7m3 182 7 glycosphingolipids glycosphingolipid NNS cord-323404-3mw4q7m3 182 8 and and CC cord-323404-3mw4q7m3 182 9 gangliosides ganglioside NNS cord-323404-3mw4q7m3 182 10 protrude protrude VBP cord-323404-3mw4q7m3 182 11 into into IN cord-323404-3mw4q7m3 182 12 the the DT cord-323404-3mw4q7m3 182 13 extracellular extracellular JJ cord-323404-3mw4q7m3 182 14 space space NN cord-323404-3mw4q7m3 182 15 and and CC cord-323404-3mw4q7m3 182 16 , , , cord-323404-3mw4q7m3 182 17 together together RB cord-323404-3mw4q7m3 182 18 with with IN cord-323404-3mw4q7m3 182 19 the the DT cord-323404-3mw4q7m3 182 20 membrane membrane NN cord-323404-3mw4q7m3 182 21 glycoproteins glycoprotein NNS cord-323404-3mw4q7m3 182 22 and and CC cord-323404-3mw4q7m3 182 23 proteoglycans proteoglycan NNS cord-323404-3mw4q7m3 182 24 , , , cord-323404-3mw4q7m3 182 25 they -PRON- PRP cord-323404-3mw4q7m3 182 26 constitute constitute VBP cord-323404-3mw4q7m3 182 27 the the DT cord-323404-3mw4q7m3 182 28 glycocalyx glycocalyx NN cord-323404-3mw4q7m3 182 29 of of IN cord-323404-3mw4q7m3 182 30 the the DT cord-323404-3mw4q7m3 182 31 cell cell NN cord-323404-3mw4q7m3 182 32 surface surface NN cord-323404-3mw4q7m3 182 33 54 54 CD cord-323404-3mw4q7m3 182 34 . . . cord-323404-3mw4q7m3 183 1 The the DT cord-323404-3mw4q7m3 183 2 multimeric multimeric JJ cord-323404-3mw4q7m3 183 3 glycoprotein glycoprotein NN cord-323404-3mw4q7m3 183 4 subunits subunit NNS cord-323404-3mw4q7m3 183 5 gp41 gp41 NNP cord-323404-3mw4q7m3 183 6 and and CC cord-323404-3mw4q7m3 183 7 gp120 gp120 NNP cord-323404-3mw4q7m3 183 8 ( ( -LRB- cord-323404-3mw4q7m3 183 9 REFS REFS NNP cord-323404-3mw4q7m3 183 10 3 3 CD cord-323404-3mw4q7m3 183 11 , , , cord-323404-3mw4q7m3 183 12 58 58 CD cord-323404-3mw4q7m3 183 13 ) ) -RRB- cord-323404-3mw4q7m3 183 14 of of IN cord-323404-3mw4q7m3 183 15 the the DT cord-323404-3mw4q7m3 183 16 HIV-1 HIV-1 NNP cord-323404-3mw4q7m3 183 17 envelope envelope NN cord-323404-3mw4q7m3 183 18 both both DT cord-323404-3mw4q7m3 183 19 attach attach VB cord-323404-3mw4q7m3 183 20 to to IN cord-323404-3mw4q7m3 183 21 the the DT cord-323404-3mw4q7m3 183 22 cell cell NN cord-323404-3mw4q7m3 183 23 - - HYPH cord-323404-3mw4q7m3 183 24 membrane membrane NN cord-323404-3mw4q7m3 183 25 glycosphingolipid glycosphingolipid NN cord-323404-3mw4q7m3 183 26 , , , cord-323404-3mw4q7m3 183 27 galactosylceramide galactosylceramide NNP cord-323404-3mw4q7m3 183 28 . . . cord-323404-3mw4q7m3 184 1 Indeed indeed RB cord-323404-3mw4q7m3 184 2 , , , cord-323404-3mw4q7m3 184 3 D d NN cord-323404-3mw4q7m3 184 4 - - HYPH cord-323404-3mw4q7m3 184 5 galactose galactose NN cord-323404-3mw4q7m3 184 6 is be VBZ cord-323404-3mw4q7m3 184 7 particularly particularly RB cord-323404-3mw4q7m3 184 8 eligible eligible JJ cord-323404-3mw4q7m3 184 9 for for IN cord-323404-3mw4q7m3 184 10 stacking stack VBG cord-323404-3mw4q7m3 184 11 to to IN cord-323404-3mw4q7m3 184 12 the the DT cord-323404-3mw4q7m3 184 13 aromatic aromatic JJ cord-323404-3mw4q7m3 184 14 ring ring NN cord-323404-3mw4q7m3 184 15 system system NN cord-323404-3mw4q7m3 184 16 of of IN cord-323404-3mw4q7m3 184 17 gp41 gp41 NNP cord-323404-3mw4q7m3 184 18 owing owe VBG cord-323404-3mw4q7m3 184 19 to to IN cord-323404-3mw4q7m3 184 20 the the DT cord-323404-3mw4q7m3 184 21 van van NNP cord-323404-3mw4q7m3 184 22 der der NNP cord-323404-3mw4q7m3 184 23 Waals Waals NNP cord-323404-3mw4q7m3 184 24 interactions interaction NNS cord-323404-3mw4q7m3 184 25 and and CC cord-323404-3mw4q7m3 184 26 the the DT cord-323404-3mw4q7m3 184 27 presence presence NN cord-323404-3mw4q7m3 184 28 of of IN cord-323404-3mw4q7m3 184 29 a a DT cord-323404-3mw4q7m3 184 30 set set NN cord-323404-3mw4q7m3 184 31 of of IN cord-323404-3mw4q7m3 184 32 polarized polarized JJ cord-323404-3mw4q7m3 184 33 C c NN cord-323404-3mw4q7m3 184 34 - - HYPH cord-323404-3mw4q7m3 184 35 H H NNP cord-323404-3mw4q7m3 184 36 bonds bond NNS cord-323404-3mw4q7m3 184 37 ( ( -LRB- cord-323404-3mw4q7m3 184 38 C C NNP cord-323404-3mw4q7m3 184 39 - - HYPH cord-323404-3mw4q7m3 184 40 H H NNP cord-323404-3mw4q7m3 184 41 / / SYM cord-323404-3mw4q7m3 184 42 π π NN cord-323404-3mw4q7m3 184 43 - - HYPH cord-323404-3mw4q7m3 184 44 electrons electron NNS cord-323404-3mw4q7m3 184 45 ) ) -RRB- cord-323404-3mw4q7m3 184 46 on on IN cord-323404-3mw4q7m3 184 47 one one CD cord-323404-3mw4q7m3 184 48 side side NN cord-323404-3mw4q7m3 184 49 of of IN cord-323404-3mw4q7m3 184 50 the the DT cord-323404-3mw4q7m3 184 51 galactose galactose NN cord-323404-3mw4q7m3 184 52 ring ring NN cord-323404-3mw4q7m3 184 53 . . . cord-323404-3mw4q7m3 185 1 Interestingly interestingly RB cord-323404-3mw4q7m3 185 2 , , , cord-323404-3mw4q7m3 185 3 HIV-1 HIV-1 NNP cord-323404-3mw4q7m3 185 4 and and CC cord-323404-3mw4q7m3 185 5 herpesvirus herpesvirus NN cord-323404-3mw4q7m3 185 6 can can MD cord-323404-3mw4q7m3 185 7 enter enter VB cord-323404-3mw4q7m3 185 8 neural neural JJ cord-323404-3mw4q7m3 185 9 cells cell NNS cord-323404-3mw4q7m3 185 10 ( ( -LRB- cord-323404-3mw4q7m3 185 11 which which WDT cord-323404-3mw4q7m3 185 12 are be VBP cord-323404-3mw4q7m3 185 13 also also RB cord-323404-3mw4q7m3 185 14 polarized polarize VBN cord-323404-3mw4q7m3 185 15 ) ) -RRB- cord-323404-3mw4q7m3 185 16 and and CC cord-323404-3mw4q7m3 185 17 mucosal mucosal JJ cord-323404-3mw4q7m3 185 18 epithelial epithelial JJ cord-323404-3mw4q7m3 185 19 cells cell NNS cord-323404-3mw4q7m3 185 20 , , , cord-323404-3mw4q7m3 185 21 both both DT cord-323404-3mw4q7m3 185 22 of of IN cord-323404-3mw4q7m3 185 23 which which WDT cord-323404-3mw4q7m3 185 24 are be VBP cord-323404-3mw4q7m3 185 25 rich rich JJ cord-323404-3mw4q7m3 185 26 in in IN cord-323404-3mw4q7m3 185 27 glycosphingolipids glycosphingolipid NNS cord-323404-3mw4q7m3 185 28 59 59 CD cord-323404-3mw4q7m3 185 29 . . . cord-323404-3mw4q7m3 186 1 HIV-1 HIV-1 NNP cord-323404-3mw4q7m3 186 2 ( ( -LRB- cord-323404-3mw4q7m3 186 3 REF REF NNP cord-323404-3mw4q7m3 186 4 . . . cord-323404-3mw4q7m3 186 5 56 56 CD cord-323404-3mw4q7m3 186 6 ) ) -RRB- cord-323404-3mw4q7m3 186 7 , , , cord-323404-3mw4q7m3 186 8 naked naked JJ cord-323404-3mw4q7m3 186 9 Ebola Ebola NNP cord-323404-3mw4q7m3 186 10 and and CC cord-323404-3mw4q7m3 186 11 Marburg Marburg NNP cord-323404-3mw4q7m3 186 12 viruses virus NNS cord-323404-3mw4q7m3 186 13 ( ( -LRB- cord-323404-3mw4q7m3 186 14 through through IN cord-323404-3mw4q7m3 186 15 their -PRON- PRP$ cord-323404-3mw4q7m3 186 16 capsid capsid NN cord-323404-3mw4q7m3 186 17 proteins protein NNS cord-323404-3mw4q7m3 186 18 ) ) -RRB- cord-323404-3mw4q7m3 186 19 and and CC cord-323404-3mw4q7m3 186 20 measles measles NN cord-323404-3mw4q7m3 186 21 virus virus NN cord-323404-3mw4q7m3 187 1 31,32 31,32 CD cord-323404-3mw4q7m3 187 2 require require VBP cord-323404-3mw4q7m3 187 3 glycosphingolipids glycosphingolipid NNS cord-323404-3mw4q7m3 187 4 to to TO cord-323404-3mw4q7m3 187 5 be be VB cord-323404-3mw4q7m3 187 6 As as IN cord-323404-3mw4q7m3 187 7 an an DT cord-323404-3mw4q7m3 187 8 alternative alternative NN cord-323404-3mw4q7m3 187 9 , , , cord-323404-3mw4q7m3 187 10 primary primary JJ cord-323404-3mw4q7m3 187 11 cells cell NNS cord-323404-3mw4q7m3 187 12 can can MD cord-323404-3mw4q7m3 187 13 be be VB cord-323404-3mw4q7m3 187 14 used use VBN cord-323404-3mw4q7m3 187 15 . . . cord-323404-3mw4q7m3 188 1 However however RB cord-323404-3mw4q7m3 188 2 , , , cord-323404-3mw4q7m3 188 3 the the DT cord-323404-3mw4q7m3 188 4 purification purification NN cord-323404-3mw4q7m3 188 5 of of IN cord-323404-3mw4q7m3 188 6 primary primary JJ cord-323404-3mw4q7m3 188 7 cells cell NNS cord-323404-3mw4q7m3 188 8 results result NNS cord-323404-3mw4q7m3 188 9 in in IN cord-323404-3mw4q7m3 188 10 the the DT cord-323404-3mw4q7m3 188 11 destruction destruction NN cord-323404-3mw4q7m3 188 12 of of IN cord-323404-3mw4q7m3 188 13 epithelial epithelial JJ cord-323404-3mw4q7m3 188 14 - - HYPH cord-323404-3mw4q7m3 188 15 barrier barrier NN cord-323404-3mw4q7m3 188 16 function function NN cord-323404-3mw4q7m3 188 17 , , , cord-323404-3mw4q7m3 188 18 and and CC cord-323404-3mw4q7m3 188 19 polarity polarity NN cord-323404-3mw4q7m3 188 20 is be VBZ cord-323404-3mw4q7m3 188 21 lost lose VBN cord-323404-3mw4q7m3 188 22 because because IN cord-323404-3mw4q7m3 188 23 primary primary JJ cord-323404-3mw4q7m3 188 24 cells cell NNS cord-323404-3mw4q7m3 188 25 can can MD cord-323404-3mw4q7m3 188 26 not not RB cord-323404-3mw4q7m3 188 27 re re VB cord-323404-3mw4q7m3 188 28 - - VB cord-323404-3mw4q7m3 188 29 form form VB cord-323404-3mw4q7m3 188 30 tight tight JJ cord-323404-3mw4q7m3 188 31 junctions junction NNS cord-323404-3mw4q7m3 188 32 in in IN cord-323404-3mw4q7m3 188 33 vitro vitro FW cord-323404-3mw4q7m3 188 34 . . . cord-323404-3mw4q7m3 189 1 Biopsies biopsy NNS cord-323404-3mw4q7m3 189 2 that that WDT cord-323404-3mw4q7m3 189 3 are be VBP cord-323404-3mw4q7m3 189 4 mounted mount VBN cord-323404-3mw4q7m3 189 5 at at IN cord-323404-3mw4q7m3 189 6 the the DT cord-323404-3mw4q7m3 189 7 interface interface NN cord-323404-3mw4q7m3 189 8 between between IN cord-323404-3mw4q7m3 189 9 two two CD cord-323404-3mw4q7m3 189 10 chambers chamber NNS cord-323404-3mw4q7m3 189 11 maintain maintain VBP cord-323404-3mw4q7m3 189 12 their -PRON- PRP$ cord-323404-3mw4q7m3 189 13 epithelial epithelial JJ cord-323404-3mw4q7m3 189 14 architecture architecture NN cord-323404-3mw4q7m3 189 15 and and CC cord-323404-3mw4q7m3 189 16 barrier barrier NN cord-323404-3mw4q7m3 189 17 function function NN cord-323404-3mw4q7m3 189 18 for for IN cord-323404-3mw4q7m3 189 19 a a DT cord-323404-3mw4q7m3 189 20 few few JJ cord-323404-3mw4q7m3 189 21 hours hour NNS cord-323404-3mw4q7m3 189 22 . . . cord-323404-3mw4q7m3 190 1 Recently recently RB cord-323404-3mw4q7m3 190 2 , , , cord-323404-3mw4q7m3 190 3 sheets sheet NNS cord-323404-3mw4q7m3 190 4 of of IN cord-323404-3mw4q7m3 190 5 epithelial epithelial JJ cord-323404-3mw4q7m3 190 6 cells cell NNS cord-323404-3mw4q7m3 190 7 with with IN cord-323404-3mw4q7m3 190 8 intact intact JJ cord-323404-3mw4q7m3 190 9 cell cell NN cord-323404-3mw4q7m3 190 10 junctions junction NNS cord-323404-3mw4q7m3 190 11 have have VBP cord-323404-3mw4q7m3 190 12 been be VBN cord-323404-3mw4q7m3 190 13 purified purify VBN cord-323404-3mw4q7m3 190 14 from from IN cord-323404-3mw4q7m3 190 15 the the DT cord-323404-3mw4q7m3 190 16 gastrointestinal gastrointestinal JJ cord-323404-3mw4q7m3 190 17 tract tract NN cord-323404-3mw4q7m3 190 18 , , , cord-323404-3mw4q7m3 190 19 but but CC cord-323404-3mw4q7m3 190 20 the the DT cord-323404-3mw4q7m3 190 21 lifespan lifespan NN cord-323404-3mw4q7m3 190 22 of of IN cord-323404-3mw4q7m3 190 23 these these DT cord-323404-3mw4q7m3 190 24 cells cell NNS cord-323404-3mw4q7m3 190 25 is be VBZ cord-323404-3mw4q7m3 190 26 less less JJR cord-323404-3mw4q7m3 190 27 than than IN cord-323404-3mw4q7m3 190 28 one one CD cord-323404-3mw4q7m3 190 29 day day NN cord-323404-3mw4q7m3 190 30 . . . cord-323404-3mw4q7m3 191 1 A a DT cord-323404-3mw4q7m3 191 2 new new JJ cord-323404-3mw4q7m3 191 3 direction direction NN cord-323404-3mw4q7m3 191 4 for for IN cord-323404-3mw4q7m3 191 5 the the DT cord-323404-3mw4q7m3 191 6 experimental experimental JJ cord-323404-3mw4q7m3 191 7 models model NNS cord-323404-3mw4q7m3 191 8 has have VBZ cord-323404-3mw4q7m3 191 9 emerged emerge VBN cord-323404-3mw4q7m3 191 10 by by IN cord-323404-3mw4q7m3 191 11 taking take VBG cord-323404-3mw4q7m3 191 12 into into IN cord-323404-3mw4q7m3 191 13 account account NN cord-323404-3mw4q7m3 191 14 the the DT cord-323404-3mw4q7m3 191 15 interaction interaction NN cord-323404-3mw4q7m3 191 16 of of IN cord-323404-3mw4q7m3 191 17 epithelial epithelial JJ cord-323404-3mw4q7m3 191 18 cells cell NNS cord-323404-3mw4q7m3 191 19 with with IN cord-323404-3mw4q7m3 191 20 submucosal submucosal NN cord-323404-3mw4q7m3 191 21 cells cell NNS cord-323404-3mw4q7m3 191 22 . . . cord-323404-3mw4q7m3 192 1 Pringault Pringault NNP cord-323404-3mw4q7m3 192 2 's 's POS cord-323404-3mw4q7m3 192 3 group group NN cord-323404-3mw4q7m3 192 4 90 90 CD cord-323404-3mw4q7m3 192 5 succeeded succeed VBD cord-323404-3mw4q7m3 192 6 in in IN cord-323404-3mw4q7m3 192 7 reconstructing reconstruct VBG cord-323404-3mw4q7m3 192 8 an an DT cord-323404-3mw4q7m3 192 9 epithelial epithelial JJ cord-323404-3mw4q7m3 192 10 barrier barrier NN cord-323404-3mw4q7m3 192 11 similar similar JJ cord-323404-3mw4q7m3 192 12 to to IN cord-323404-3mw4q7m3 192 13 those those DT cord-323404-3mw4q7m3 192 14 that that WDT cord-323404-3mw4q7m3 192 15 cover cover VBP cord-323404-3mw4q7m3 192 16 lymphoid lymphoid JJ cord-323404-3mw4q7m3 192 17 organs organ NNS cord-323404-3mw4q7m3 192 18 , , , cord-323404-3mw4q7m3 192 19 which which WDT cord-323404-3mw4q7m3 192 20 included include VBD cord-323404-3mw4q7m3 192 21 M M NNP cord-323404-3mw4q7m3 192 22 cells cell NNS cord-323404-3mw4q7m3 192 23 . . . cord-323404-3mw4q7m3 193 1 They -PRON- PRP cord-323404-3mw4q7m3 193 2 did do VBD cord-323404-3mw4q7m3 193 3 this this DT cord-323404-3mw4q7m3 193 4 by by IN cord-323404-3mw4q7m3 193 5 co co NN cord-323404-3mw4q7m3 193 6 - - JJ cord-323404-3mw4q7m3 193 7 culturing culture VBG cord-323404-3mw4q7m3 193 8 transformed transform VBN cord-323404-3mw4q7m3 193 9 intestinal intestinal JJ cord-323404-3mw4q7m3 193 10 epithelial epithelial JJ cord-323404-3mw4q7m3 193 11 cells cell NNS cord-323404-3mw4q7m3 193 12 with with IN cord-323404-3mw4q7m3 193 13 primary primary JJ cord-323404-3mw4q7m3 193 14 intraepithelial intraepithelial JJ cord-323404-3mw4q7m3 193 15 lymphocytes lymphocyte NNS cord-323404-3mw4q7m3 193 16 . . . cord-323404-3mw4q7m3 194 1 Such such JJ cord-323404-3mw4q7m3 194 2 co co JJ cord-323404-3mw4q7m3 194 3 - - JJ cord-323404-3mw4q7m3 194 4 culture culture JJ cord-323404-3mw4q7m3 194 5 systems system NNS cord-323404-3mw4q7m3 194 6 preserve preserve VBP cord-323404-3mw4q7m3 194 7 the the DT cord-323404-3mw4q7m3 194 8 barrier barrier NN cord-323404-3mw4q7m3 194 9 function function NN cord-323404-3mw4q7m3 194 10 of of IN cord-323404-3mw4q7m3 194 11 monostratified monostratified JJ cord-323404-3mw4q7m3 194 12 primary primary JJ cord-323404-3mw4q7m3 194 13 epithelial epithelial JJ cord-323404-3mw4q7m3 194 14 cells cell NNS cord-323404-3mw4q7m3 194 15 . . . cord-323404-3mw4q7m3 195 1 HeLa HeLa NNP cord-323404-3mw4q7m3 195 2 ( ( -LRB- cord-323404-3mw4q7m3 195 3 cervical cervical JJ cord-323404-3mw4q7m3 195 4 carcinoma carcinoma NN cord-323404-3mw4q7m3 195 5 ) ) -RRB- cord-323404-3mw4q7m3 195 6 cells cell NNS cord-323404-3mw4q7m3 195 7 have have VBP cord-323404-3mw4q7m3 195 8 been be VBN cord-323404-3mw4q7m3 195 9 widely widely RB cord-323404-3mw4q7m3 195 10 used use VBN cord-323404-3mw4q7m3 195 11 as as IN cord-323404-3mw4q7m3 195 12 pluristratified pluristratified JJ cord-323404-3mw4q7m3 195 13 epithelium epithelium NN cord-323404-3mw4q7m3 195 14 , , , cord-323404-3mw4q7m3 195 15 which which WDT cord-323404-3mw4q7m3 195 16 is be VBZ cord-323404-3mw4q7m3 195 17 mainly mainly RB cord-323404-3mw4q7m3 195 18 because because IN cord-323404-3mw4q7m3 195 19 they -PRON- PRP cord-323404-3mw4q7m3 195 20 grow grow VBP cord-323404-3mw4q7m3 195 21 well well RB cord-323404-3mw4q7m3 195 22 and and CC cord-323404-3mw4q7m3 195 23 are be VBP cord-323404-3mw4q7m3 195 24 easily easily RB cord-323404-3mw4q7m3 195 25 transfectable transfectable JJ cord-323404-3mw4q7m3 195 26 . . . cord-323404-3mw4q7m3 196 1 However however RB cord-323404-3mw4q7m3 196 2 , , , cord-323404-3mw4q7m3 196 3 they -PRON- PRP cord-323404-3mw4q7m3 196 4 differ differ VBP cord-323404-3mw4q7m3 196 5 considerably considerably RB cord-323404-3mw4q7m3 196 6 from from IN cord-323404-3mw4q7m3 196 7 primary primary JJ cord-323404-3mw4q7m3 196 8 cells cell NNS cord-323404-3mw4q7m3 196 9 , , , cord-323404-3mw4q7m3 196 10 which which WDT cord-323404-3mw4q7m3 196 11 are be VBP cord-323404-3mw4q7m3 196 12 difficult difficult JJ cord-323404-3mw4q7m3 196 13 to to TO cord-323404-3mw4q7m3 196 14 maintain maintain VB cord-323404-3mw4q7m3 196 15 in in IN cord-323404-3mw4q7m3 196 16 culture culture NN cord-323404-3mw4q7m3 196 17 as as IN cord-323404-3mw4q7m3 196 18 an an DT cord-323404-3mw4q7m3 196 19 organized organized JJ cord-323404-3mw4q7m3 196 20 tissue tissue NN cord-323404-3mw4q7m3 196 21 . . . cord-323404-3mw4q7m3 197 1 SIALYLOLIGOSACCHARIDE SIALYLOLIGOSACCHARIDE NNP cord-323404-3mw4q7m3 198 1 An an DT cord-323404-3mw4q7m3 198 2 oligosaccharide oligosaccharide NN cord-323404-3mw4q7m3 198 3 chain chain NN cord-323404-3mw4q7m3 198 4 that that WDT cord-323404-3mw4q7m3 198 5 is be VBZ cord-323404-3mw4q7m3 198 6 linked link VBN cord-323404-3mw4q7m3 198 7 to to IN cord-323404-3mw4q7m3 198 8 a a DT cord-323404-3mw4q7m3 198 9 terminal terminal JJ cord-323404-3mw4q7m3 198 10 sialic sialic NN cord-323404-3mw4q7m3 198 11 acid acid NN cord-323404-3mw4q7m3 198 12 ( ( -LRB- cord-323404-3mw4q7m3 198 13 N N NNP cord-323404-3mw4q7m3 198 14 - - HYPH cord-323404-3mw4q7m3 198 15 acetyl acetyl NN cord-323404-3mw4q7m3 198 16 neuraminic neuraminic JJ cord-323404-3mw4q7m3 198 17 acid acid NNP cord-323404-3mw4q7m3 198 18 ) ) -RRB- cord-323404-3mw4q7m3 198 19 . . . cord-323404-3mw4q7m3 199 1 GLYCOSAMINOGLYCAN GLYCOSAMINOGLYCAN NNP cord-323404-3mw4q7m3 200 1 The the DT cord-323404-3mw4q7m3 200 2 polysaccharide polysaccharide NN cord-323404-3mw4q7m3 200 3 moiety moiety NN cord-323404-3mw4q7m3 200 4 of of IN cord-323404-3mw4q7m3 200 5 proteoglycans proteoglycan NNS cord-323404-3mw4q7m3 200 6 , , , cord-323404-3mw4q7m3 200 7 which which WDT cord-323404-3mw4q7m3 200 8 is be VBZ cord-323404-3mw4q7m3 200 9 added add VBN cord-323404-3mw4q7m3 200 10 posttranslationally posttranslationally RB cord-323404-3mw4q7m3 200 11 and and CC cord-323404-3mw4q7m3 200 12 is be VBZ cord-323404-3mw4q7m3 200 13 composed compose VBN cord-323404-3mw4q7m3 200 14 of of IN cord-323404-3mw4q7m3 200 15 repeating repeat VBG cord-323404-3mw4q7m3 200 16 disaccharide disaccharide JJ cord-323404-3mw4q7m3 200 17 units unit NNS cord-323404-3mw4q7m3 200 18 . . . cord-323404-3mw4q7m3 201 1 One one CD cord-323404-3mw4q7m3 201 2 of of IN cord-323404-3mw4q7m3 201 3 the the DT cord-323404-3mw4q7m3 201 4 glycosaminoglycan glycosaminoglycan JJ cord-323404-3mw4q7m3 201 5 parts part NNS cord-323404-3mw4q7m3 201 6 of of IN cord-323404-3mw4q7m3 201 7 proteoglycans proteoglycan NNS cord-323404-3mw4q7m3 201 8 , , , cord-323404-3mw4q7m3 201 9 this this DT cord-323404-3mw4q7m3 201 10 is be VBZ cord-323404-3mw4q7m3 201 11 a a DT cord-323404-3mw4q7m3 201 12 long long JJ cord-323404-3mw4q7m3 201 13 , , , cord-323404-3mw4q7m3 201 14 polyanionic polyanionic JJ cord-323404-3mw4q7m3 201 15 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 201 16 chain chain NN cord-323404-3mw4q7m3 201 17 that that WDT cord-323404-3mw4q7m3 201 18 consists consist VBZ cord-323404-3mw4q7m3 201 19 of of IN cord-323404-3mw4q7m3 201 20 a a DT cord-323404-3mw4q7m3 201 21 repeating repeat VBG cord-323404-3mw4q7m3 201 22 disaccharide disaccharide JJ cord-323404-3mw4q7m3 201 23 unit unit NN cord-323404-3mw4q7m3 201 24 . . . cord-323404-3mw4q7m3 202 1 GLYCOSYNAPSE GLYCOSYNAPSE NNP cord-323404-3mw4q7m3 203 1 A a DT cord-323404-3mw4q7m3 203 2 membrane membrane NN cord-323404-3mw4q7m3 203 3 structure structure NN cord-323404-3mw4q7m3 203 4 that that WDT cord-323404-3mw4q7m3 203 5 provides provide VBZ cord-323404-3mw4q7m3 203 6 a a DT cord-323404-3mw4q7m3 203 7 connection connection NN cord-323404-3mw4q7m3 203 8 between between IN cord-323404-3mw4q7m3 203 9 two two CD cord-323404-3mw4q7m3 203 10 cells cell NNS cord-323404-3mw4q7m3 203 11 , , , cord-323404-3mw4q7m3 203 12 and and CC cord-323404-3mw4q7m3 203 13 is be VBZ cord-323404-3mw4q7m3 203 14 involved involve VBN cord-323404-3mw4q7m3 203 15 in in IN cord-323404-3mw4q7m3 203 16 a a DT cord-323404-3mw4q7m3 203 17 glycosylation glycosylation NN cord-323404-3mw4q7m3 203 18 - - HYPH cord-323404-3mw4q7m3 203 19 dependent dependent JJ cord-323404-3mw4q7m3 203 20 celladhesion celladhesion NN cord-323404-3mw4q7m3 203 21 / / SYM cord-323404-3mw4q7m3 203 22 recognition recognition NN cord-323404-3mw4q7m3 203 23 processes process NNS cord-323404-3mw4q7m3 203 24 . . . cord-323404-3mw4q7m3 204 1 www.nature.com/reviews/molcellbio www.nature.com/reviews/molcellbio NNP cord-323404-3mw4q7m3 205 1 R r NN cord-323404-3mw4q7m3 205 2 E e NN cord-323404-3mw4q7m3 205 3 V v NN cord-323404-3mw4q7m3 206 1 I -PRON- PRP cord-323404-3mw4q7m3 206 2 E E NNP cord-323404-3mw4q7m3 206 3 W W NNP cord-323404-3mw4q7m3 206 4 S S NNP cord-323404-3mw4q7m3 206 5 epithelial epithelial JJ cord-323404-3mw4q7m3 206 6 cell cell NN cord-323404-3mw4q7m3 206 7 surface surface NN cord-323404-3mw4q7m3 206 8 , , , cord-323404-3mw4q7m3 206 9 but but CC cord-323404-3mw4q7m3 206 10 HPEV-1 HPEV-1 NNS cord-323404-3mw4q7m3 206 11 then then RB cord-323404-3mw4q7m3 206 12 enters enter VBZ cord-323404-3mw4q7m3 206 13 the the DT cord-323404-3mw4q7m3 206 14 host host NN cord-323404-3mw4q7m3 206 15 cell cell NN cord-323404-3mw4q7m3 206 16 through through IN cord-323404-3mw4q7m3 206 17 the the DT cord-323404-3mw4q7m3 206 18 clathrin clathrin NN cord-323404-3mw4q7m3 206 19 - - HYPH cord-323404-3mw4q7m3 206 20 dependent dependent JJ cord-323404-3mw4q7m3 206 21 endocytic endocytic JJ cord-323404-3mw4q7m3 206 22 pathway pathway NN cord-323404-3mw4q7m3 206 23 38 38 CD cord-323404-3mw4q7m3 206 24 . . . cord-323404-3mw4q7m3 207 1 As as IN cord-323404-3mw4q7m3 207 2 an an DT cord-323404-3mw4q7m3 207 3 alternative alternative NN cord-323404-3mw4q7m3 207 4 , , , cord-323404-3mw4q7m3 207 5 viral viral JJ cord-323404-3mw4q7m3 207 6 proteins protein NNS cord-323404-3mw4q7m3 207 7 might may MD cord-323404-3mw4q7m3 207 8 use use VB cord-323404-3mw4q7m3 207 9 other other JJ cord-323404-3mw4q7m3 207 10 motifs motif NNS cord-323404-3mw4q7m3 207 11 to to TO cord-323404-3mw4q7m3 207 12 bind bind VB cord-323404-3mw4q7m3 207 13 RGD RGD NNP cord-323404-3mw4q7m3 207 14 - - HYPH cord-323404-3mw4q7m3 207 15 sensitive sensitive JJ cord-323404-3mw4q7m3 207 16 integrins integrin NNS cord-323404-3mw4q7m3 207 17 in in IN cord-323404-3mw4q7m3 207 18 an an DT cord-323404-3mw4q7m3 207 19 RGDindependent rgdindependent NN cord-323404-3mw4q7m3 207 20 fashion fashion NN cord-323404-3mw4q7m3 207 21 ( ( -LRB- cord-323404-3mw4q7m3 207 22 that that RB cord-323404-3mw4q7m3 207 23 is is RB cord-323404-3mw4q7m3 207 24 , , , cord-323404-3mw4q7m3 207 25 the the DT cord-323404-3mw4q7m3 207 26 viral viral JJ cord-323404-3mw4q7m3 207 27 protein protein NN cord-323404-3mw4q7m3 207 28 does do VBZ cord-323404-3mw4q7m3 207 29 not not RB cord-323404-3mw4q7m3 207 30 act act VB cord-323404-3mw4q7m3 207 31 as as IN cord-323404-3mw4q7m3 207 32 a a DT cord-323404-3mw4q7m3 207 33 physiological physiological JJ cord-323404-3mw4q7m3 207 34 counter counter NN cord-323404-3mw4q7m3 207 35 - - NN cord-323404-3mw4q7m3 207 36 ligand ligand JJ cord-323404-3mw4q7m3 207 37 ) ) -RRB- cord-323404-3mw4q7m3 207 38 . . . cord-323404-3mw4q7m3 208 1 For for IN cord-323404-3mw4q7m3 208 2 example example NN cord-323404-3mw4q7m3 208 3 , , , cord-323404-3mw4q7m3 208 4 rotaviral rotaviral NNP cord-323404-3mw4q7m3 208 5 VP4 VP4 NNP cord-323404-3mw4q7m3 208 6 protein protein NN cord-323404-3mw4q7m3 208 7 binds bind VBZ cord-323404-3mw4q7m3 208 8 the the DT cord-323404-3mw4q7m3 208 9 RGD RGD NNP cord-323404-3mw4q7m3 208 10 - - HYPH cord-323404-3mw4q7m3 208 11 sensitive sensitive JJ cord-323404-3mw4q7m3 208 12 integrin integrin NN cord-323404-3mw4q7m3 208 13 - - : cord-323404-3mw4q7m3 208 14 α α NN cord-323404-3mw4q7m3 208 15 2 2 CD cord-323404-3mw4q7m3 208 16 β β NN cord-323404-3mw4q7m3 208 17 1 1 CD cord-323404-3mw4q7m3 208 18 , , , cord-323404-3mw4q7m3 208 19 which which WDT cord-323404-3mw4q7m3 208 20 is be VBZ cord-323404-3mw4q7m3 208 21 basolaterally basolaterally RB cord-323404-3mw4q7m3 208 22 expressed express VBN cord-323404-3mw4q7m3 208 23 ( ( -LRB- cord-323404-3mw4q7m3 208 24 or or CC cord-323404-3mw4q7m3 208 25 , , , cord-323404-3mw4q7m3 208 26 alternatively alternatively RB cord-323404-3mw4q7m3 208 27 , , , cord-323404-3mw4q7m3 208 28 it -PRON- PRP cord-323404-3mw4q7m3 208 29 binds bind VBZ cord-323404-3mw4q7m3 208 30 integrin integrin NN cord-323404-3mw4q7m3 208 31 - - HYPH cord-323404-3mw4q7m3 208 32 α α NN cord-323404-3mw4q7m3 208 33 v v NN cord-323404-3mw4q7m3 208 34 β β NN cord-323404-3mw4q7m3 208 35 3 3 CD cord-323404-3mw4q7m3 208 36 ) ) -RRB- cord-323404-3mw4q7m3 208 37 , , , cord-323404-3mw4q7m3 208 38 as as IN cord-323404-3mw4q7m3 208 39 a a DT cord-323404-3mw4q7m3 208 40 post post JJ cord-323404-3mw4q7m3 208 41 - - JJ cord-323404-3mw4q7m3 208 42 attachment attachment JJ cord-323404-3mw4q7m3 208 43 receptor receptor NN cord-323404-3mw4q7m3 208 44 through through IN cord-323404-3mw4q7m3 208 45 the the DT cord-323404-3mw4q7m3 208 46 GDE(A gde(a CD cord-323404-3mw4q7m3 208 47 ) ) -RRB- cord-323404-3mw4q7m3 209 1 ( ( -LRB- cord-323404-3mw4q7m3 209 2 glycine glycine NN cord-323404-3mw4q7m3 209 3 - - HYPH cord-323404-3mw4q7m3 209 4 aspartic aspartic JJ cord-323404-3mw4q7m3 209 5 acid acid NN cord-323404-3mw4q7m3 209 6 - - HYPH cord-323404-3mw4q7m3 209 7 glutamic glutamic NN cord-323404-3mw4q7m3 209 8 acid acid NN cord-323404-3mw4q7m3 209 9 / / SYM cord-323404-3mw4q7m3 209 10 alanine alanine NN cord-323404-3mw4q7m3 209 11 ) ) -RRB- cord-323404-3mw4q7m3 209 12 amino amino NN cord-323404-3mw4q7m3 209 13 - - HYPH cord-323404-3mw4q7m3 209 14 acid acid NN cord-323404-3mw4q7m3 209 15 motif motif NN cord-323404-3mw4q7m3 209 16 of of IN cord-323404-3mw4q7m3 209 17 the the DT cord-323404-3mw4q7m3 209 18 viral viral JJ cord-323404-3mw4q7m3 209 19 protein protein NN cord-323404-3mw4q7m3 209 20 73 73 CD cord-323404-3mw4q7m3 209 21 , , , cord-323404-3mw4q7m3 209 22 76 76 CD cord-323404-3mw4q7m3 209 23 , , , cord-323404-3mw4q7m3 209 24 77 77 CD cord-323404-3mw4q7m3 209 25 . . . cord-323404-3mw4q7m3 210 1 When when WRB cord-323404-3mw4q7m3 210 2 both both DT cord-323404-3mw4q7m3 210 3 of of IN cord-323404-3mw4q7m3 210 4 these these DT cord-323404-3mw4q7m3 210 5 integrins integrin NNS cord-323404-3mw4q7m3 210 6 are be VBP cord-323404-3mw4q7m3 210 7 expressed express VBN cord-323404-3mw4q7m3 210 8 at at IN cord-323404-3mw4q7m3 210 9 the the DT cord-323404-3mw4q7m3 210 10 epithelial epithelial JJ cord-323404-3mw4q7m3 210 11 - - HYPH cord-323404-3mw4q7m3 210 12 cell cell NN cord-323404-3mw4q7m3 210 13 surface surface NN cord-323404-3mw4q7m3 210 14 , , , cord-323404-3mw4q7m3 210 15 they -PRON- PRP cord-323404-3mw4q7m3 210 16 work work VBP cord-323404-3mw4q7m3 210 17 together together RB cord-323404-3mw4q7m3 210 18 to to TO cord-323404-3mw4q7m3 210 19 promote promote VB cord-323404-3mw4q7m3 210 20 viral viral JJ cord-323404-3mw4q7m3 210 21 entry entry NN cord-323404-3mw4q7m3 210 22 78 78 CD cord-323404-3mw4q7m3 210 23 . . . cord-323404-3mw4q7m3 211 1 The the DT cord-323404-3mw4q7m3 211 2 rotaviral rotaviral JJ cord-323404-3mw4q7m3 211 3 VP7 VP7 NNP cord-323404-3mw4q7m3 211 4 protein protein NN cord-323404-3mw4q7m3 211 5 interacts interact VBZ cord-323404-3mw4q7m3 211 6 with with IN cord-323404-3mw4q7m3 211 7 integrin integrin NN cord-323404-3mw4q7m3 211 8 - - HYPH cord-323404-3mw4q7m3 211 9 α α NN cord-323404-3mw4q7m3 211 10 x x SYM cord-323404-3mw4q7m3 211 11 β β NN cord-323404-3mw4q7m3 211 12 2 2 CD cord-323404-3mw4q7m3 211 13 through through IN cord-323404-3mw4q7m3 211 14 a a DT cord-323404-3mw4q7m3 211 15 GRP grp NN cord-323404-3mw4q7m3 211 16 ( ( -LRB- cord-323404-3mw4q7m3 211 17 glycine glycine NN cord-323404-3mw4q7m3 211 18 - - HYPH cord-323404-3mw4q7m3 211 19 arginine arginine NN cord-323404-3mw4q7m3 211 20 - - HYPH cord-323404-3mw4q7m3 211 21 proline proline NN cord-323404-3mw4q7m3 211 22 ) ) -RRB- cord-323404-3mw4q7m3 211 23 motif motif NN cord-323404-3mw4q7m3 211 24 , , , cord-323404-3mw4q7m3 211 25 and and CC cord-323404-3mw4q7m3 211 26 integrin integrin NN cord-323404-3mw4q7m3 211 27 - - : cord-323404-3mw4q7m3 211 28 α α NN cord-323404-3mw4q7m3 211 29 4 4 CD cord-323404-3mw4q7m3 211 30 β β NN cord-323404-3mw4q7m3 211 31 1 1 CD cord-323404-3mw4q7m3 211 32 through through IN cord-323404-3mw4q7m3 211 33 an an DT cord-323404-3mw4q7m3 211 34 LVD LVD NNP cord-323404-3mw4q7m3 211 35 ( ( -LRB- cord-323404-3mw4q7m3 211 36 leucine leucine NN cord-323404-3mw4q7m3 211 37 - - HYPH cord-323404-3mw4q7m3 211 38 valine valine NN cord-323404-3mw4q7m3 211 39 - - HYPH cord-323404-3mw4q7m3 211 40 aspartic aspartic JJ cord-323404-3mw4q7m3 211 41 acid acid NN cord-323404-3mw4q7m3 211 42 ) ) -RRB- cord-323404-3mw4q7m3 211 43 amino amino NN cord-323404-3mw4q7m3 211 44 - - HYPH cord-323404-3mw4q7m3 211 45 acid acid NN cord-323404-3mw4q7m3 211 46 motif motif NN cord-323404-3mw4q7m3 211 47 77 77 CD cord-323404-3mw4q7m3 211 48 . . . cord-323404-3mw4q7m3 212 1 Direct direct JJ cord-323404-3mw4q7m3 212 2 interaction interaction NN cord-323404-3mw4q7m3 212 3 between between IN cord-323404-3mw4q7m3 212 4 VP4 VP4 NNP cord-323404-3mw4q7m3 212 5 and and CC cord-323404-3mw4q7m3 212 6 VP7 vp7 NN cord-323404-3mw4q7m3 212 7 has have VBZ cord-323404-3mw4q7m3 212 8 been be VBN cord-323404-3mw4q7m3 212 9 observed observe VBN cord-323404-3mw4q7m3 212 10 . . . cord-323404-3mw4q7m3 213 1 Adenoviruses adenovirus NNS cord-323404-3mw4q7m3 213 2 use use VBP cord-323404-3mw4q7m3 213 3 also also RB cord-323404-3mw4q7m3 213 4 integrin integrin NN cord-323404-3mw4q7m3 213 5 - - HYPH cord-323404-3mw4q7m3 213 6 α α NN cord-323404-3mw4q7m3 213 7 v v NN cord-323404-3mw4q7m3 213 8 as as IN cord-323404-3mw4q7m3 213 9 a a DT cord-323404-3mw4q7m3 213 10 receptor receptor NN cord-323404-3mw4q7m3 213 11 to to TO cord-323404-3mw4q7m3 213 12 mediate mediate VB cord-323404-3mw4q7m3 213 13 their -PRON- PRP$ cord-323404-3mw4q7m3 213 14 endocytosis endocytosis NN cord-323404-3mw4q7m3 213 15 , , , cord-323404-3mw4q7m3 213 16 but but CC cord-323404-3mw4q7m3 213 17 binding binding NN cord-323404-3mw4q7m3 213 18 of of IN cord-323404-3mw4q7m3 213 19 the the DT cord-323404-3mw4q7m3 213 20 virus virus NN cord-323404-3mw4q7m3 213 21 to to IN cord-323404-3mw4q7m3 213 22 the the DT cord-323404-3mw4q7m3 213 23 integrin integrin NN cord-323404-3mw4q7m3 213 24 activates activate VBZ cord-323404-3mw4q7m3 213 25 a a DT cord-323404-3mw4q7m3 213 26 signalling signal VBG cord-323404-3mw4q7m3 213 27 pathway pathway NN cord-323404-3mw4q7m3 213 28 that that WDT cord-323404-3mw4q7m3 213 29 is be VBZ cord-323404-3mw4q7m3 213 30 distinct distinct JJ cord-323404-3mw4q7m3 213 31 from from IN cord-323404-3mw4q7m3 213 32 the the DT cord-323404-3mw4q7m3 213 33 physiological physiological JJ cord-323404-3mw4q7m3 213 34 one one CD cord-323404-3mw4q7m3 213 35 79 79 CD cord-323404-3mw4q7m3 213 36 . . . cord-323404-3mw4q7m3 214 1 Echoviruses echovirus NNS cord-323404-3mw4q7m3 214 2 bind bind VBP cord-323404-3mw4q7m3 214 3 to to IN cord-323404-3mw4q7m3 214 4 integrinα integrinα NNP cord-323404-3mw4q7m3 214 5 2 2 CD cord-323404-3mw4q7m3 214 6 β β NN cord-323404-3mw4q7m3 214 7 1 1 CD cord-323404-3mw4q7m3 214 8 , , , cord-323404-3mw4q7m3 214 9 and and CC cord-323404-3mw4q7m3 214 10 during during IN cord-323404-3mw4q7m3 214 11 viral viral JJ cord-323404-3mw4q7m3 214 12 entry entry NN cord-323404-3mw4q7m3 214 13 , , , cord-323404-3mw4q7m3 214 14 caveolin caveolin NN cord-323404-3mw4q7m3 214 15 1 1 CD cord-323404-3mw4q7m3 214 16 and and CC cord-323404-3mw4q7m3 214 17 integrin integrin NN cord-323404-3mw4q7m3 214 18 - - HYPH cord-323404-3mw4q7m3 214 19 α α NN cord-323404-3mw4q7m3 214 20 2 2 CD cord-323404-3mw4q7m3 214 21 β β NN cord-323404-3mw4q7m3 214 22 1 1 CD cord-323404-3mw4q7m3 214 23 co co NN cord-323404-3mw4q7m3 214 24 - - NN cord-323404-3mw4q7m3 214 25 localize localize VB cord-323404-3mw4q7m3 214 26 with with IN cord-323404-3mw4q7m3 214 27 E-1 E-1 NNP cord-323404-3mw4q7m3 214 28 capsid capsid NN cord-323404-3mw4q7m3 214 29 proteins protein NNS cord-323404-3mw4q7m3 214 30 and and CC cord-323404-3mw4q7m3 214 31 migrate migrate VB cord-323404-3mw4q7m3 214 32 into into IN cord-323404-3mw4q7m3 214 33 the the DT cord-323404-3mw4q7m3 214 34 perinuclear perinuclear NNP cord-323404-3mw4q7m3 214 35 area area NN cord-323404-3mw4q7m3 214 36 in in IN cord-323404-3mw4q7m3 214 37 the the DT cord-323404-3mw4q7m3 214 38 cell cell NN cord-323404-3mw4q7m3 214 39 80 80 CD cord-323404-3mw4q7m3 214 40 . . . cord-323404-3mw4q7m3 215 1 Other other JJ cord-323404-3mw4q7m3 215 2 adhesion adhesion NN cord-323404-3mw4q7m3 215 3 molecules molecule NNS cord-323404-3mw4q7m3 215 4 , , , cord-323404-3mw4q7m3 215 5 such such JJ cord-323404-3mw4q7m3 215 6 as as IN cord-323404-3mw4q7m3 215 7 intercellular intercellular JJ cord-323404-3mw4q7m3 215 8 adhesion adhesion NN cord-323404-3mw4q7m3 215 9 molecule molecule NN cord-323404-3mw4q7m3 215 10 1 1 CD cord-323404-3mw4q7m3 215 11 ( ( -LRB- cord-323404-3mw4q7m3 215 12 ICAM1 ICAM1 NNP cord-323404-3mw4q7m3 215 13 ) ) -RRB- cord-323404-3mw4q7m3 215 14 , , , cord-323404-3mw4q7m3 215 15 function function VBP cord-323404-3mw4q7m3 215 16 as as IN cord-323404-3mw4q7m3 215 17 viral viral JJ cord-323404-3mw4q7m3 215 18 receptors receptor NNS cord-323404-3mw4q7m3 215 19 on on IN cord-323404-3mw4q7m3 215 20 epithelial epithelial JJ cord-323404-3mw4q7m3 215 21 cells cell NNS cord-323404-3mw4q7m3 215 22 . . . cord-323404-3mw4q7m3 216 1 The the DT cord-323404-3mw4q7m3 216 2 major major JJ cord-323404-3mw4q7m3 216 3 group group NN cord-323404-3mw4q7m3 216 4 of of IN cord-323404-3mw4q7m3 216 5 HRV HRV NNP cord-323404-3mw4q7m3 216 6 uses use VBZ cord-323404-3mw4q7m3 216 7 ICAM1 ICAM1 NNP cord-323404-3mw4q7m3 216 8 as as IN cord-323404-3mw4q7m3 216 9 the the DT cord-323404-3mw4q7m3 216 10 viral viral JJ cord-323404-3mw4q7m3 216 11 receptor receptor NN cord-323404-3mw4q7m3 216 12 81 81 CD cord-323404-3mw4q7m3 216 13 . . . cord-323404-3mw4q7m3 217 1 HRVs HRVs NNP cord-323404-3mw4q7m3 217 2 have have VBP cord-323404-3mw4q7m3 217 3 a a DT cord-323404-3mw4q7m3 217 4 cleft cleft NN cord-323404-3mw4q7m3 217 5 that that WDT cord-323404-3mw4q7m3 217 6 encircles encircle VBZ cord-323404-3mw4q7m3 217 7 the the DT cord-323404-3mw4q7m3 217 8 fivefold fivefold JJ cord-323404-3mw4q7m3 217 9 axes axis NNS cord-323404-3mw4q7m3 217 10 of of IN cord-323404-3mw4q7m3 217 11 icosahedral icosahedral JJ cord-323404-3mw4q7m3 217 12 symmetry symmetry NN cord-323404-3mw4q7m3 217 13 , , , cord-323404-3mw4q7m3 217 14 which which WDT cord-323404-3mw4q7m3 217 15 accommodates accommodate VBZ cord-323404-3mw4q7m3 217 16 the the DT cord-323404-3mw4q7m3 217 17 amino amino NN cord-323404-3mw4q7m3 217 18 - - HYPH cord-323404-3mw4q7m3 217 19 terminal terminal NN cord-323404-3mw4q7m3 217 20 domain domain NN cord-323404-3mw4q7m3 217 21 of of IN cord-323404-3mw4q7m3 217 22 ICAM1 ICAM1 NNP cord-323404-3mw4q7m3 217 23 . . . cord-323404-3mw4q7m3 218 1 Another another DT cord-323404-3mw4q7m3 218 2 widely widely RB cord-323404-3mw4q7m3 218 3 used use VBN cord-323404-3mw4q7m3 218 4 class class NN cord-323404-3mw4q7m3 218 5 of of IN cord-323404-3mw4q7m3 218 6 receptor receptor NN cord-323404-3mw4q7m3 218 7 consists consist VBZ cord-323404-3mw4q7m3 218 8 of of IN cord-323404-3mw4q7m3 218 9 components component NNS cord-323404-3mw4q7m3 218 10 of of IN cord-323404-3mw4q7m3 218 11 the the DT cord-323404-3mw4q7m3 218 12 epithelialcell epithelialcell JJ cord-323404-3mw4q7m3 218 13 tight tight JJ cord-323404-3mw4q7m3 218 14 junctions junction NNS cord-323404-3mw4q7m3 218 15 . . . cord-323404-3mw4q7m3 219 1 The the DT cord-323404-3mw4q7m3 219 2 use use NN cord-323404-3mw4q7m3 219 3 of of IN cord-323404-3mw4q7m3 219 4 such such JJ cord-323404-3mw4q7m3 219 5 receptors receptor NNS cord-323404-3mw4q7m3 219 6 to to TO cord-323404-3mw4q7m3 219 7 penetrate penetrate VB cord-323404-3mw4q7m3 219 8 epithelial epithelial JJ cord-323404-3mw4q7m3 219 9 - - HYPH cord-323404-3mw4q7m3 219 10 cell cell NN cord-323404-3mw4q7m3 219 11 cytosol cytosol NN cord-323404-3mw4q7m3 219 12 at at IN cord-323404-3mw4q7m3 219 13 the the DT cord-323404-3mw4q7m3 219 14 epithelial epithelial JJ cord-323404-3mw4q7m3 219 15 cell cell NN cord-323404-3mw4q7m3 219 16 - - HYPH cord-323404-3mw4q7m3 219 17 cell cell NN cord-323404-3mw4q7m3 219 18 junction junction NN cord-323404-3mw4q7m3 219 19 implies imply VBZ cord-323404-3mw4q7m3 219 20 that that IN cord-323404-3mw4q7m3 219 21 the the DT cord-323404-3mw4q7m3 219 22 junction junction NN cord-323404-3mw4q7m3 219 23 complex complex NN cord-323404-3mw4q7m3 219 24 is be VBZ cord-323404-3mw4q7m3 219 25 disrupted disrupt VBN cord-323404-3mw4q7m3 219 26 , , , cord-323404-3mw4q7m3 219 27 with with IN cord-323404-3mw4q7m3 219 28 an an DT cord-323404-3mw4q7m3 219 29 immediate immediate JJ cord-323404-3mw4q7m3 219 30 effect effect NN cord-323404-3mw4q7m3 219 31 on on IN cord-323404-3mw4q7m3 219 32 the the DT cord-323404-3mw4q7m3 219 33 integrity integrity NN cord-323404-3mw4q7m3 219 34 of of IN cord-323404-3mw4q7m3 219 35 the the DT cord-323404-3mw4q7m3 219 36 epithelial epithelial JJ cord-323404-3mw4q7m3 219 37 barrier barrier NN cord-323404-3mw4q7m3 219 38 . . . cord-323404-3mw4q7m3 220 1 Whereas whereas IN cord-323404-3mw4q7m3 220 2 the the DT cord-323404-3mw4q7m3 220 3 interaction interaction NN cord-323404-3mw4q7m3 220 4 of of IN cord-323404-3mw4q7m3 220 5 viral viral JJ cord-323404-3mw4q7m3 220 6 components component NNS cord-323404-3mw4q7m3 220 7 with with IN cord-323404-3mw4q7m3 220 8 components component NNS cord-323404-3mw4q7m3 220 9 of of IN cord-323404-3mw4q7m3 220 10 the the DT cord-323404-3mw4q7m3 220 11 epithelial epithelial JJ cord-323404-3mw4q7m3 220 12 tight tight JJ cord-323404-3mw4q7m3 220 13 junction junction NN cord-323404-3mw4q7m3 220 14 has have VBZ cord-323404-3mw4q7m3 220 15 been be VBN cord-323404-3mw4q7m3 220 16 described describe VBN cord-323404-3mw4q7m3 220 17 biochemically biochemically RB cord-323404-3mw4q7m3 220 18 69 69 CD cord-323404-3mw4q7m3 220 19 , , , cord-323404-3mw4q7m3 220 20 how how WRB cord-323404-3mw4q7m3 220 21 viruses virus NNS cord-323404-3mw4q7m3 220 22 access access VBP cord-323404-3mw4q7m3 220 23 such such JJ cord-323404-3mw4q7m3 220 24 receptors receptor NNS cord-323404-3mw4q7m3 221 1 -which -which JJS cord-323404-3mw4q7m3 221 2 are be VBP cord-323404-3mw4q7m3 221 3 ' ' `` cord-323404-3mw4q7m3 221 4 hidden'in hidden'in NNP cord-323404-3mw4q7m3 221 5 the the DT cord-323404-3mw4q7m3 221 6 tight tight JJ cord-323404-3mw4q7m3 221 7 junction junction NN cord-323404-3mw4q7m3 221 8 in in IN cord-323404-3mw4q7m3 221 9 vivo vivo NN cord-323404-3mw4q7m3 222 1 -is -is : cord-323404-3mw4q7m3 222 2 difficult difficult JJ cord-323404-3mw4q7m3 222 3 to to TO cord-323404-3mw4q7m3 222 4 clarify clarify VB cord-323404-3mw4q7m3 222 5 , , , cord-323404-3mw4q7m3 222 6 despite despite IN cord-323404-3mw4q7m3 222 7 recent recent JJ cord-323404-3mw4q7m3 222 8 studies study NNS cord-323404-3mw4q7m3 222 9 on on IN cord-323404-3mw4q7m3 222 10 cell cell NN cord-323404-3mw4q7m3 222 11 lines line NNS cord-323404-3mw4q7m3 222 12 17 17 CD cord-323404-3mw4q7m3 222 13 . . . cord-323404-3mw4q7m3 223 1 Two two CD cord-323404-3mw4q7m3 223 2 cell cell NN cord-323404-3mw4q7m3 223 3 - - HYPH cord-323404-3mw4q7m3 223 4 surface surface NN cord-323404-3mw4q7m3 223 5 glycoproteins glycoprotein NNS cord-323404-3mw4q7m3 223 6 -the -the ADD cord-323404-3mw4q7m3 223 7 coxsackievirus coxsackievirus NNP cord-323404-3mw4q7m3 223 8 and and CC cord-323404-3mw4q7m3 223 9 adenovirus adenovirus NN cord-323404-3mw4q7m3 223 10 receptor receptor NN cord-323404-3mw4q7m3 223 11 ( ( -LRB- cord-323404-3mw4q7m3 223 12 CAR car NN cord-323404-3mw4q7m3 223 13 ) ) -RRB- cord-323404-3mw4q7m3 223 14 and and CC cord-323404-3mw4q7m3 223 15 the the DT cord-323404-3mw4q7m3 223 16 junction junction NN cord-323404-3mw4q7m3 223 17 - - HYPH cord-323404-3mw4q7m3 223 18 adhesion adhesion NN cord-323404-3mw4q7m3 223 19 molecule molecule NN cord-323404-3mw4q7m3 223 20 ( ( -LRB- cord-323404-3mw4q7m3 223 21 JAM jam NN cord-323404-3mw4q7m3 223 22 ) ) -RRB- cord-323404-3mw4q7m3 223 23 -were -were . cord-323404-3mw4q7m3 223 24 identified identify VBN cord-323404-3mw4q7m3 223 25 as as IN cord-323404-3mw4q7m3 223 26 transmembrane transmembrane JJ cord-323404-3mw4q7m3 223 27 components component NNS cord-323404-3mw4q7m3 223 28 of of IN cord-323404-3mw4q7m3 223 29 the the DT cord-323404-3mw4q7m3 223 30 tight tight JJ cord-323404-3mw4q7m3 223 31 junction junction NN cord-323404-3mw4q7m3 223 32 in in IN cord-323404-3mw4q7m3 223 33 epithelial epithelial JJ cord-323404-3mw4q7m3 223 34 cells cell NNS cord-323404-3mw4q7m3 223 35 , , , cord-323404-3mw4q7m3 223 36 as as RB cord-323404-3mw4q7m3 223 37 well well RB cord-323404-3mw4q7m3 223 38 as as IN cord-323404-3mw4q7m3 223 39 being be VBG cord-323404-3mw4q7m3 223 40 entry entry NN cord-323404-3mw4q7m3 223 41 receptors receptor NNS cord-323404-3mw4q7m3 223 42 for for IN cord-323404-3mw4q7m3 223 43 coxsackie coxsackie NNP cord-323404-3mw4q7m3 223 44 virus virus NNP cord-323404-3mw4q7m3 223 45 / / SYM cord-323404-3mw4q7m3 223 46 adenovirus adenovirus NN cord-323404-3mw4q7m3 223 47 and and CC cord-323404-3mw4q7m3 223 48 reovirus reovirus NN cord-323404-3mw4q7m3 223 49 , , , cord-323404-3mw4q7m3 223 50 respectively respectively RB cord-323404-3mw4q7m3 223 51 69,82 69,82 CD cord-323404-3mw4q7m3 223 52 . . . cord-323404-3mw4q7m3 224 1 Owing owe VBG cord-323404-3mw4q7m3 224 2 to to IN cord-323404-3mw4q7m3 224 3 the the DT cord-323404-3mw4q7m3 224 4 localization localization NN cord-323404-3mw4q7m3 224 5 of of IN cord-323404-3mw4q7m3 224 6 CAR car NN cord-323404-3mw4q7m3 224 7 at at IN cord-323404-3mw4q7m3 224 8 the the DT cord-323404-3mw4q7m3 224 9 tight tight JJ cord-323404-3mw4q7m3 224 10 junction junction NN cord-323404-3mw4q7m3 224 11 , , , cord-323404-3mw4q7m3 224 12 infection infection NN cord-323404-3mw4q7m3 224 13 by by IN cord-323404-3mw4q7m3 224 14 both both DT cord-323404-3mw4q7m3 224 15 adenovirus adenovirus NN cord-323404-3mw4q7m3 224 16 and and CC cord-323404-3mw4q7m3 224 17 coxsackievirus coxsackievirus NNP cord-323404-3mw4q7m3 224 18 in in IN cord-323404-3mw4q7m3 224 19 vivo vivo NN cord-323404-3mw4q7m3 224 20 could could MD cord-323404-3mw4q7m3 224 21 require require VB cord-323404-3mw4q7m3 224 22 the the DT cord-323404-3mw4q7m3 224 23 destruction destruction NN cord-323404-3mw4q7m3 224 24 of of IN cord-323404-3mw4q7m3 224 25 the the DT cord-323404-3mw4q7m3 224 26 tight tight JJ cord-323404-3mw4q7m3 224 27 - - HYPH cord-323404-3mw4q7m3 224 28 junction junction NN cord-323404-3mw4q7m3 224 29 complex complex NN cord-323404-3mw4q7m3 224 30 for for IN cord-323404-3mw4q7m3 224 31 the the DT cord-323404-3mw4q7m3 224 32 virus virus NN cord-323404-3mw4q7m3 224 33 to to TO cord-323404-3mw4q7m3 224 34 be be VB cord-323404-3mw4q7m3 224 35 able able JJ cord-323404-3mw4q7m3 224 36 to to TO cord-323404-3mw4q7m3 224 37 access access VB cord-323404-3mw4q7m3 224 38 its -PRON- PRP$ cord-323404-3mw4q7m3 224 39 receptor receptor NN cord-323404-3mw4q7m3 224 40 , , , cord-323404-3mw4q7m3 224 41 as as IN cord-323404-3mw4q7m3 224 42 is be VBZ cord-323404-3mw4q7m3 224 43 the the DT cord-323404-3mw4q7m3 224 44 case case NN cord-323404-3mw4q7m3 224 45 in in IN cord-323404-3mw4q7m3 224 46 vitro vitro NNP cord-323404-3mw4q7m3 224 47 82 82 CD cord-323404-3mw4q7m3 224 48 . . . cord-323404-3mw4q7m3 225 1 Such such JJ cord-323404-3mw4q7m3 225 2 destruction destruction NN cord-323404-3mw4q7m3 225 3 might may MD cord-323404-3mw4q7m3 225 4 be be VB cord-323404-3mw4q7m3 225 5 involved involve VBN cord-323404-3mw4q7m3 225 6 in in IN cord-323404-3mw4q7m3 225 7 regulating regulate VBG cord-323404-3mw4q7m3 225 8 tissue tissue NN cord-323404-3mw4q7m3 225 9 - - HYPH cord-323404-3mw4q7m3 225 10 specific specific JJ cord-323404-3mw4q7m3 225 11 inflammatory inflammatory JJ cord-323404-3mw4q7m3 225 12 responses response NNS cord-323404-3mw4q7m3 225 13 to to IN cord-323404-3mw4q7m3 225 14 viral viral JJ cord-323404-3mw4q7m3 225 15 infection infection NN cord-323404-3mw4q7m3 225 16 69 69 CD cord-323404-3mw4q7m3 225 17 . . . cord-323404-3mw4q7m3 226 1 Coxsackievirus Coxsackievirus NNP cord-323404-3mw4q7m3 226 2 binds bind VBZ cord-323404-3mw4q7m3 226 3 CAR car NN cord-323404-3mw4q7m3 226 4 through through IN cord-323404-3mw4q7m3 226 5 a a DT cord-323404-3mw4q7m3 226 6 ' ' `` cord-323404-3mw4q7m3 226 7 canyon canyon NN cord-323404-3mw4q7m3 226 8 ' ' '' cord-323404-3mw4q7m3 226 9 at at IN cord-323404-3mw4q7m3 226 10 the the DT cord-323404-3mw4q7m3 226 11 surface surface NN cord-323404-3mw4q7m3 226 12 of of IN cord-323404-3mw4q7m3 226 13 the the DT cord-323404-3mw4q7m3 226 14 virus virus NN cord-323404-3mw4q7m3 226 15 . . . cord-323404-3mw4q7m3 227 1 By by IN cord-323404-3mw4q7m3 227 2 Finally finally RB cord-323404-3mw4q7m3 227 3 , , , cord-323404-3mw4q7m3 227 4 the the DT cord-323404-3mw4q7m3 227 5 glycosylation glycosylation NN cord-323404-3mw4q7m3 227 6 state state NN cord-323404-3mw4q7m3 227 7 of of IN cord-323404-3mw4q7m3 227 8 epithelial epithelial JJ cord-323404-3mw4q7m3 227 9 - - HYPH cord-323404-3mw4q7m3 227 10 cell cell NN cord-323404-3mw4q7m3 227 11 - - HYPH cord-323404-3mw4q7m3 227 12 surface surface NN cord-323404-3mw4q7m3 227 13 proteins protein NNS cord-323404-3mw4q7m3 227 14 and and CC cord-323404-3mw4q7m3 227 15 lipids lipid NNS cord-323404-3mw4q7m3 227 16 varies vary VBZ cord-323404-3mw4q7m3 227 17 with with IN cord-323404-3mw4q7m3 227 18 the the DT cord-323404-3mw4q7m3 227 19 differentiation differentiation NN cord-323404-3mw4q7m3 227 20 , , , cord-323404-3mw4q7m3 227 21 ageing ageing NN cord-323404-3mw4q7m3 227 22 and and CC cord-323404-3mw4q7m3 227 23 activation activation NN cord-323404-3mw4q7m3 227 24 of of IN cord-323404-3mw4q7m3 227 25 the the DT cord-323404-3mw4q7m3 227 26 cell cell NN cord-323404-3mw4q7m3 227 27 , , , cord-323404-3mw4q7m3 227 28 and and CC cord-323404-3mw4q7m3 227 29 such such JJ cord-323404-3mw4q7m3 227 30 modulation modulation NN cord-323404-3mw4q7m3 227 31 of of IN cord-323404-3mw4q7m3 227 32 surface surface NN cord-323404-3mw4q7m3 227 33 carbohydrates carbohydrate NNS cord-323404-3mw4q7m3 227 34 has have VBZ cord-323404-3mw4q7m3 227 35 an an DT cord-323404-3mw4q7m3 227 36 evident evident JJ cord-323404-3mw4q7m3 227 37 effect effect NN cord-323404-3mw4q7m3 227 38 on on IN cord-323404-3mw4q7m3 227 39 the the DT cord-323404-3mw4q7m3 227 40 susceptibility susceptibility NN cord-323404-3mw4q7m3 227 41 of of IN cord-323404-3mw4q7m3 227 42 epithelial epithelial JJ cord-323404-3mw4q7m3 227 43 cells cell NNS cord-323404-3mw4q7m3 227 44 to to IN cord-323404-3mw4q7m3 227 45 viral viral JJ cord-323404-3mw4q7m3 227 46 infection infection NN cord-323404-3mw4q7m3 227 47 54 54 CD cord-323404-3mw4q7m3 227 48 . . . cord-323404-3mw4q7m3 228 1 Several several JJ cord-323404-3mw4q7m3 228 2 classes class NNS cord-323404-3mw4q7m3 228 3 of of IN cord-323404-3mw4q7m3 228 4 protein protein NN cord-323404-3mw4q7m3 228 5 receptor receptor NN cord-323404-3mw4q7m3 228 6 , , , cord-323404-3mw4q7m3 228 7 which which WDT cord-323404-3mw4q7m3 228 8 often often RB cord-323404-3mw4q7m3 228 9 show show VBP cord-323404-3mw4q7m3 228 10 a a DT cord-323404-3mw4q7m3 228 11 polarized polarized JJ cord-323404-3mw4q7m3 228 12 distribution distribution NN cord-323404-3mw4q7m3 228 13 , , , cord-323404-3mw4q7m3 228 14 are be VBP cord-323404-3mw4q7m3 228 15 used use VBN cord-323404-3mw4q7m3 228 16 opportunistically opportunistically RB cord-323404-3mw4q7m3 228 17 by by IN cord-323404-3mw4q7m3 228 18 viruses virus NNS cord-323404-3mw4q7m3 228 19 to to TO cord-323404-3mw4q7m3 228 20 attach attach VB cord-323404-3mw4q7m3 228 21 to to TO cord-323404-3mw4q7m3 228 22 and and CC cord-323404-3mw4q7m3 228 23 infect infect VB cord-323404-3mw4q7m3 228 24 cells cell NNS cord-323404-3mw4q7m3 228 25 . . . cord-323404-3mw4q7m3 229 1 A a DT cord-323404-3mw4q7m3 229 2 protein protein NN cord-323404-3mw4q7m3 229 3 receptor receptor NN cord-323404-3mw4q7m3 229 4 either either CC cord-323404-3mw4q7m3 229 5 mediates mediate VBZ cord-323404-3mw4q7m3 229 6 these these DT cord-323404-3mw4q7m3 229 7 sequential sequential JJ cord-323404-3mw4q7m3 229 8 steps step NNS cord-323404-3mw4q7m3 229 9 by by IN cord-323404-3mw4q7m3 229 10 itself -PRON- PRP cord-323404-3mw4q7m3 229 11 , , , cord-323404-3mw4q7m3 229 12 or or CC cord-323404-3mw4q7m3 229 13 it -PRON- PRP cord-323404-3mw4q7m3 229 14 has have VBZ cord-323404-3mw4q7m3 229 15 to to TO cord-323404-3mw4q7m3 229 16 cooperate cooperate VB cord-323404-3mw4q7m3 229 17 with with IN cord-323404-3mw4q7m3 229 18 attachment attachment NN cord-323404-3mw4q7m3 229 19 receptors receptor NNS cord-323404-3mw4q7m3 229 20 . . . cord-323404-3mw4q7m3 230 1 As as IN cord-323404-3mw4q7m3 230 2 mentioned mention VBN cord-323404-3mw4q7m3 230 3 above above RB cord-323404-3mw4q7m3 230 4 , , , cord-323404-3mw4q7m3 230 5 few few JJ cord-323404-3mw4q7m3 230 6 studies study NNS cord-323404-3mw4q7m3 230 7 describe describe VBP cord-323404-3mw4q7m3 230 8 the the DT cord-323404-3mw4q7m3 230 9 mechanism mechanism NN cord-323404-3mw4q7m3 230 10 of of IN cord-323404-3mw4q7m3 230 11 such such JJ cord-323404-3mw4q7m3 230 12 cooperativity cooperativity NN cord-323404-3mw4q7m3 230 13 . . . cord-323404-3mw4q7m3 231 1 Integrins Integrins NNP cord-323404-3mw4q7m3 231 2 are be VBP cord-323404-3mw4q7m3 231 3 a a DT cord-323404-3mw4q7m3 231 4 class class NN cord-323404-3mw4q7m3 231 5 of of IN cord-323404-3mw4q7m3 231 6 surface surface NN cord-323404-3mw4q7m3 231 7 molecules molecule NNS cord-323404-3mw4q7m3 231 8 that that WDT cord-323404-3mw4q7m3 231 9 are be VBP cord-323404-3mw4q7m3 231 10 used use VBN cord-323404-3mw4q7m3 231 11 by by IN cord-323404-3mw4q7m3 231 12 several several JJ cord-323404-3mw4q7m3 231 13 viruses virus NNS cord-323404-3mw4q7m3 231 14 ( ( -LRB- cord-323404-3mw4q7m3 231 15 enveloped envelop VBN cord-323404-3mw4q7m3 231 16 and and CC cord-323404-3mw4q7m3 231 17 naked naked JJ cord-323404-3mw4q7m3 231 18 ) ) -RRB- cord-323404-3mw4q7m3 231 19 to to TO cord-323404-3mw4q7m3 231 20 attach attach VB cord-323404-3mw4q7m3 231 21 to to TO cord-323404-3mw4q7m3 231 22 and and CC cord-323404-3mw4q7m3 231 23 infect infect VB cord-323404-3mw4q7m3 231 24 epithelial epithelial JJ cord-323404-3mw4q7m3 231 25 cells cell NNS cord-323404-3mw4q7m3 231 26 . . . cord-323404-3mw4q7m3 232 1 One one CD cord-323404-3mw4q7m3 232 2 class class NN cord-323404-3mw4q7m3 232 3 of of IN cord-323404-3mw4q7m3 232 4 integrin integrin NN cord-323404-3mw4q7m3 232 5 , , , cord-323404-3mw4q7m3 232 6 the the DT cord-323404-3mw4q7m3 232 7 cellular cellular JJ cord-323404-3mw4q7m3 232 8 role role NN cord-323404-3mw4q7m3 232 9 of of IN cord-323404-3mw4q7m3 232 10 which which WDT cord-323404-3mw4q7m3 232 11 is be VBZ cord-323404-3mw4q7m3 232 12 to to TO cord-323404-3mw4q7m3 232 13 maintain maintain VB cord-323404-3mw4q7m3 232 14 cell cell NN cord-323404-3mw4q7m3 232 15 - - HYPH cord-323404-3mw4q7m3 232 16 cell cell NN cord-323404-3mw4q7m3 232 17 contact contact NN cord-323404-3mw4q7m3 232 18 , , , cord-323404-3mw4q7m3 232 19 is be VBZ cord-323404-3mw4q7m3 232 20 expressed express VBN cord-323404-3mw4q7m3 232 21 basolaterally basolaterally RB cord-323404-3mw4q7m3 232 22 in in IN cord-323404-3mw4q7m3 232 23 cell cell NN cord-323404-3mw4q7m3 232 24 culture culture NN cord-323404-3mw4q7m3 232 25 and and CC cord-323404-3mw4q7m3 232 26 in in IN cord-323404-3mw4q7m3 232 27 gut gut NN cord-323404-3mw4q7m3 232 28 tissue tissue NN cord-323404-3mw4q7m3 232 29 adjacent adjacent JJ cord-323404-3mw4q7m3 232 30 to to IN cord-323404-3mw4q7m3 232 31 the the DT cord-323404-3mw4q7m3 232 32 tight tight JJ cord-323404-3mw4q7m3 232 33 - - HYPH cord-323404-3mw4q7m3 232 34 junction junction NN cord-323404-3mw4q7m3 232 35 complex complex NN cord-323404-3mw4q7m3 232 36 on on IN cord-323404-3mw4q7m3 232 37 the the DT cord-323404-3mw4q7m3 232 38 basolateral basolateral JJ cord-323404-3mw4q7m3 232 39 pole pole NN cord-323404-3mw4q7m3 232 40 . . . cord-323404-3mw4q7m3 233 1 However however RB cord-323404-3mw4q7m3 233 2 , , , cord-323404-3mw4q7m3 233 3 other other JJ cord-323404-3mw4q7m3 233 4 integrins integrin NNS cord-323404-3mw4q7m3 233 5 , , , cord-323404-3mw4q7m3 233 6 such such JJ cord-323404-3mw4q7m3 233 7 as as IN cord-323404-3mw4q7m3 233 8 α α NN cord-323404-3mw4q7m3 233 9 2 2 CD cord-323404-3mw4q7m3 233 10 β β NN cord-323404-3mw4q7m3 233 11 1 1 CD cord-323404-3mw4q7m3 233 12 , , , cord-323404-3mw4q7m3 233 13 are be VBP cord-323404-3mw4q7m3 233 14 expressed express VBN cord-323404-3mw4q7m3 233 15 apically apically RB cord-323404-3mw4q7m3 233 16 in in IN cord-323404-3mw4q7m3 233 17 crypt crypt NN cord-323404-3mw4q7m3 233 18 and and CC cord-323404-3mw4q7m3 233 19 villus villus JJ cord-323404-3mw4q7m3 233 20 ENTEROCYTES enterocyte NNS cord-323404-3mw4q7m3 233 21 throughout throughout IN cord-323404-3mw4q7m3 233 22 the the DT cord-323404-3mw4q7m3 233 23 intestine intestine NN cord-323404-3mw4q7m3 233 24 . . . cord-323404-3mw4q7m3 234 1 Integrins integrin NNS cord-323404-3mw4q7m3 234 2 that that WDT cord-323404-3mw4q7m3 234 3 are be VBP cord-323404-3mw4q7m3 234 4 expressed express VBN cord-323404-3mw4q7m3 234 5 at at IN cord-323404-3mw4q7m3 234 6 the the DT cord-323404-3mw4q7m3 234 7 cell cell NN cord-323404-3mw4q7m3 234 8 surface surface NN cord-323404-3mw4q7m3 234 9 bind bind NN cord-323404-3mw4q7m3 234 10 to to IN cord-323404-3mw4q7m3 234 11 ligands ligand NNS cord-323404-3mw4q7m3 234 12 that that WDT cord-323404-3mw4q7m3 234 13 are be VBP cord-323404-3mw4q7m3 234 14 referred refer VBN cord-323404-3mw4q7m3 234 15 to to IN cord-323404-3mw4q7m3 234 16 as as IN cord-323404-3mw4q7m3 234 17 disintegrins disintegrin NNS cord-323404-3mw4q7m3 234 18 . . . cord-323404-3mw4q7m3 235 1 These these DT cord-323404-3mw4q7m3 235 2 disintegrins disintegrin NNS cord-323404-3mw4q7m3 235 3 contain contain VBP cord-323404-3mw4q7m3 235 4 motifs motif NNS cord-323404-3mw4q7m3 235 5 of of IN cord-323404-3mw4q7m3 235 6 several several JJ cord-323404-3mw4q7m3 235 7 amino amino NN cord-323404-3mw4q7m3 235 8 acids acid NNS cord-323404-3mw4q7m3 235 9 that that WDT cord-323404-3mw4q7m3 235 10 are be VBP cord-323404-3mw4q7m3 235 11 specific specific JJ cord-323404-3mw4q7m3 235 12 to to IN cord-323404-3mw4q7m3 235 13 each each DT cord-323404-3mw4q7m3 235 14 integrin integrin NN cord-323404-3mw4q7m3 235 15 . . . cord-323404-3mw4q7m3 236 1 One one CD cord-323404-3mw4q7m3 236 2 of of IN cord-323404-3mw4q7m3 236 3 these these DT cord-323404-3mw4q7m3 236 4 motifs motif NNS cord-323404-3mw4q7m3 236 5 -RGD -RGD . cord-323404-3mw4q7m3 237 1 ( ( -LRB- cord-323404-3mw4q7m3 237 2 arginine arginine NN cord-323404-3mw4q7m3 237 3 - - HYPH cord-323404-3mw4q7m3 237 4 glycine glycine NN cord-323404-3mw4q7m3 237 5 - - HYPH cord-323404-3mw4q7m3 237 6 aspartic aspartic JJ cord-323404-3mw4q7m3 237 7 acid acid NN cord-323404-3mw4q7m3 237 8 ) ) -RRB- cord-323404-3mw4q7m3 238 1 -is -is . cord-323404-3mw4q7m3 239 1 specific specific JJ cord-323404-3mw4q7m3 239 2 to to IN cord-323404-3mw4q7m3 239 3 a a DT cord-323404-3mw4q7m3 239 4 set set NN cord-323404-3mw4q7m3 239 5 of of IN cord-323404-3mw4q7m3 239 6 integrins integrin NNS cord-323404-3mw4q7m3 239 7 that that WDT cord-323404-3mw4q7m3 239 8 are be VBP cord-323404-3mw4q7m3 239 9 known know VBN cord-323404-3mw4q7m3 239 10 as as IN cord-323404-3mw4q7m3 239 11 RGD RGD NNP cord-323404-3mw4q7m3 239 12 - - HYPH cord-323404-3mw4q7m3 239 13 sensitive sensitive JJ cord-323404-3mw4q7m3 239 14 integrins integrin NNS cord-323404-3mw4q7m3 239 15 . . . cord-323404-3mw4q7m3 240 1 Disintegrin Disintegrin NNP cord-323404-3mw4q7m3 240 2 motifs motif NNS cord-323404-3mw4q7m3 240 3 are be VBP cord-323404-3mw4q7m3 240 4 found find VBN cord-323404-3mw4q7m3 240 5 in in IN cord-323404-3mw4q7m3 240 6 viral viral JJ cord-323404-3mw4q7m3 240 7 surface surface NN cord-323404-3mw4q7m3 240 8 proteins protein NNS cord-323404-3mw4q7m3 240 9 , , , cord-323404-3mw4q7m3 240 10 which which WDT cord-323404-3mw4q7m3 240 11 allows allow VBZ cord-323404-3mw4q7m3 240 12 the the DT cord-323404-3mw4q7m3 240 13 virus virus NN cord-323404-3mw4q7m3 240 14 to to TO cord-323404-3mw4q7m3 240 15 bind bind VB cord-323404-3mw4q7m3 240 16 integrins integrin NNS cord-323404-3mw4q7m3 240 17 , , , cord-323404-3mw4q7m3 240 18 and and CC cord-323404-3mw4q7m3 240 19 thereby thereby RB cord-323404-3mw4q7m3 240 20 interferes interfere VBZ cord-323404-3mw4q7m3 240 21 with with IN cord-323404-3mw4q7m3 240 22 the the DT cord-323404-3mw4q7m3 240 23 bona bona JJ cord-323404-3mw4q7m3 240 24 fide fide JJ cord-323404-3mw4q7m3 240 25 ligand ligand NN cord-323404-3mw4q7m3 240 26 . . . cord-323404-3mw4q7m3 241 1 A a DT cord-323404-3mw4q7m3 241 2 restricted restricted JJ cord-323404-3mw4q7m3 241 3 set set NN cord-323404-3mw4q7m3 241 4 of of IN cord-323404-3mw4q7m3 241 5 RGD RGD NNP cord-323404-3mw4q7m3 241 6 - - HYPH cord-323404-3mw4q7m3 241 7 sensitive sensitive JJ cord-323404-3mw4q7m3 241 8 integrins integrin NNS cord-323404-3mw4q7m3 241 9 often often RB cord-323404-3mw4q7m3 241 10 seems seem VBZ cord-323404-3mw4q7m3 241 11 to to TO cord-323404-3mw4q7m3 241 12 be be VB cord-323404-3mw4q7m3 241 13 used use VBN cord-323404-3mw4q7m3 241 14 by by IN cord-323404-3mw4q7m3 241 15 viruses virus NNS cord-323404-3mw4q7m3 241 16 38 38 CD cord-323404-3mw4q7m3 241 17 , , , cord-323404-3mw4q7m3 241 18 73 73 CD cord-323404-3mw4q7m3 241 19 . . . cord-323404-3mw4q7m3 242 1 Several several JJ cord-323404-3mw4q7m3 242 2 viruses virus NNS cord-323404-3mw4q7m3 242 3 bind bind VBP cord-323404-3mw4q7m3 242 4 RGD RGD NNP cord-323404-3mw4q7m3 242 5 - - HYPH cord-323404-3mw4q7m3 242 6 sensitive sensitive JJ cord-323404-3mw4q7m3 242 7 integrins integrin NNS cord-323404-3mw4q7m3 242 8 in in IN cord-323404-3mw4q7m3 242 9 an an DT cord-323404-3mw4q7m3 242 10 RGD RGD NNP cord-323404-3mw4q7m3 242 11 - - HYPH cord-323404-3mw4q7m3 242 12 dependent dependent JJ cord-323404-3mw4q7m3 242 13 manner manner NN cord-323404-3mw4q7m3 242 14 74 74 CD cord-323404-3mw4q7m3 242 15 . . . cord-323404-3mw4q7m3 243 1 For for IN cord-323404-3mw4q7m3 243 2 example example NN cord-323404-3mw4q7m3 243 3 , , , cord-323404-3mw4q7m3 243 4 the the DT cord-323404-3mw4q7m3 243 5 RGD RGD NNP cord-323404-3mw4q7m3 243 6 motif motif NN cord-323404-3mw4q7m3 243 7 of of IN cord-323404-3mw4q7m3 243 8 the the DT cord-323404-3mw4q7m3 243 9 HHV-8 HHV-8 NNP cord-323404-3mw4q7m3 243 10 envelope envelope NN cord-323404-3mw4q7m3 243 11 glycoprotein glycoprotein NN cord-323404-3mw4q7m3 243 12 B b NN cord-323404-3mw4q7m3 243 13 interacts interact VBZ cord-323404-3mw4q7m3 243 14 with with IN cord-323404-3mw4q7m3 243 15 integrin integrin NN cord-323404-3mw4q7m3 243 16 - - : cord-323404-3mw4q7m3 243 17 α α NN cord-323404-3mw4q7m3 243 18 3 3 CD cord-323404-3mw4q7m3 243 19 β β NN cord-323404-3mw4q7m3 243 20 1 1 CD cord-323404-3mw4q7m3 243 21 to to TO cord-323404-3mw4q7m3 243 22 allow allow VB cord-323404-3mw4q7m3 243 23 attachment attachment NN cord-323404-3mw4q7m3 243 24 of of IN cord-323404-3mw4q7m3 243 25 HHV-8 HHV-8 NNP cord-323404-3mw4q7m3 243 26 to to IN cord-323404-3mw4q7m3 243 27 ( ( -LRB- cord-323404-3mw4q7m3 243 28 and and CC cord-323404-3mw4q7m3 243 29 the the DT cord-323404-3mw4q7m3 243 30 infection infection NN cord-323404-3mw4q7m3 243 31 of of IN cord-323404-3mw4q7m3 243 32 ) ) -RRB- cord-323404-3mw4q7m3 243 33 epithelial epithelial JJ cord-323404-3mw4q7m3 243 34 cells cell NNS cord-323404-3mw4q7m3 243 35 and and CC cord-323404-3mw4q7m3 243 36 use use NN cord-323404-3mw4q7m3 243 37 of of IN cord-323404-3mw4q7m3 243 38 the the DT cord-323404-3mw4q7m3 243 39 integrin integrin NN cord-323404-3mw4q7m3 243 40 signalling signal VBG cord-323404-3mw4q7m3 243 41 pathway pathway NN cord-323404-3mw4q7m3 243 42 75 75 CD cord-323404-3mw4q7m3 243 43 . . . cord-323404-3mw4q7m3 244 1 The the DT cord-323404-3mw4q7m3 244 2 RGD RGD NNP cord-323404-3mw4q7m3 244 3 - - HYPH cord-323404-3mw4q7m3 244 4 containing contain VBG cord-323404-3mw4q7m3 244 5 capsid capsid NN cord-323404-3mw4q7m3 244 6 protein protein NN cord-323404-3mw4q7m3 244 7 VP1 vp1 NN cord-323404-3mw4q7m3 244 8 of of IN cord-323404-3mw4q7m3 244 9 FMDV FMDV NNP cord-323404-3mw4q7m3 244 10 attaches attach VBZ cord-323404-3mw4q7m3 244 11 to to IN cord-323404-3mw4q7m3 244 12 the the DT cord-323404-3mw4q7m3 244 13 integrin integrin NN cord-323404-3mw4q7m3 244 14 - - HYPH cord-323404-3mw4q7m3 244 15 α α NN cord-323404-3mw4q7m3 244 16 v v NN cord-323404-3mw4q7m3 244 17 β β NN cord-323404-3mw4q7m3 244 18 6 6 CD cord-323404-3mw4q7m3 244 19 , , , cord-323404-3mw4q7m3 244 20 which which WDT cord-323404-3mw4q7m3 244 21 is be VBZ cord-323404-3mw4q7m3 244 22 expressed express VBN cord-323404-3mw4q7m3 244 23 on on IN cord-323404-3mw4q7m3 244 24 primary primary JJ cord-323404-3mw4q7m3 244 25 epithelial epithelial JJ cord-323404-3mw4q7m3 244 26 cells cell NNS cord-323404-3mw4q7m3 244 27 , , , cord-323404-3mw4q7m3 244 28 then then RB cord-323404-3mw4q7m3 244 29 uses use VBZ cord-323404-3mw4q7m3 244 30 the the DT cord-323404-3mw4q7m3 244 31 signalling signal VBG cord-323404-3mw4q7m3 244 32 pathways pathway NNS cord-323404-3mw4q7m3 244 33 that that WDT cord-323404-3mw4q7m3 244 34 are be VBP cord-323404-3mw4q7m3 244 35 initiated initiate VBN cord-323404-3mw4q7m3 244 36 at at IN cord-323404-3mw4q7m3 244 37 the the DT cord-323404-3mw4q7m3 244 38 integrinβ integrinβ JJ cord-323404-3mw4q7m3 244 39 6 6 CD cord-323404-3mw4q7m3 244 40 cytoplasmic cytoplasmic JJ cord-323404-3mw4q7m3 244 41 domain domain NN cord-323404-3mw4q7m3 244 42 71 71 CD cord-323404-3mw4q7m3 244 43 . . . cord-323404-3mw4q7m3 245 1 The the DT cord-323404-3mw4q7m3 245 2 RGD RGD NNP cord-323404-3mw4q7m3 245 3 - - HYPH cord-323404-3mw4q7m3 245 4 containing contain VBG cord-323404-3mw4q7m3 245 5 capsid capsid NN cord-323404-3mw4q7m3 245 6 protein protein NN cord-323404-3mw4q7m3 245 7 VP1 VP1 NNP cord-323404-3mw4q7m3 245 8 of of IN cord-323404-3mw4q7m3 245 9 human human JJ cord-323404-3mw4q7m3 245 10 parechovirus parechovirus NNP cord-323404-3mw4q7m3 245 11 1 1 CD cord-323404-3mw4q7m3 245 12 ( ( -LRB- cord-323404-3mw4q7m3 245 13 HPEV-1 HPEV-1 NNP cord-323404-3mw4q7m3 245 14 ) ) -RRB- cord-323404-3mw4q7m3 245 15 also also RB cord-323404-3mw4q7m3 245 16 interacts interact VBZ cord-323404-3mw4q7m3 245 17 with with IN cord-323404-3mw4q7m3 245 18 integrins integrin NNS cord-323404-3mw4q7m3 245 19 -α -α . cord-323404-3mw4q7m3 246 1 v v NNP cord-323404-3mw4q7m3 246 2 β β NN cord-323404-3mw4q7m3 246 3 3 3 CD cord-323404-3mw4q7m3 246 4 and and CC cord-323404-3mw4q7m3 246 5 α α NN cord-323404-3mw4q7m3 246 6 v v NN cord-323404-3mw4q7m3 246 7 β β NN cord-323404-3mw4q7m3 246 8 1 1 CD cord-323404-3mw4q7m3 246 9 -on -on . cord-323404-3mw4q7m3 247 1 the the DT cord-323404-3mw4q7m3 247 2 Viruses virus NNS cord-323404-3mw4q7m3 247 3 can can MD cord-323404-3mw4q7m3 247 4 contact contact VB cord-323404-3mw4q7m3 247 5 the the DT cord-323404-3mw4q7m3 247 6 epithelium epithelium NN cord-323404-3mw4q7m3 247 7 as as IN cord-323404-3mw4q7m3 247 8 two two CD cord-323404-3mw4q7m3 247 9 forms form NNS cord-323404-3mw4q7m3 247 10 -as -as CD cord-323404-3mw4q7m3 247 11 cell cell NN cord-323404-3mw4q7m3 247 12 - - HYPH cord-323404-3mw4q7m3 247 13 free free JJ cord-323404-3mw4q7m3 247 14 viral viral JJ cord-323404-3mw4q7m3 247 15 particles particle NNS cord-323404-3mw4q7m3 247 16 or or CC cord-323404-3mw4q7m3 247 17 as as IN cord-323404-3mw4q7m3 247 18 an an DT cord-323404-3mw4q7m3 247 19 infected infected JJ cord-323404-3mw4q7m3 247 20 cell cell NN cord-323404-3mw4q7m3 247 21 . . . cord-323404-3mw4q7m3 248 1 Most Most JJS cord-323404-3mw4q7m3 248 2 studies study NNS cord-323404-3mw4q7m3 248 3 have have VBP cord-323404-3mw4q7m3 248 4 been be VBN cord-323404-3mw4q7m3 248 5 carried carry VBN cord-323404-3mw4q7m3 248 6 out out RP cord-323404-3mw4q7m3 248 7 using use VBG cord-323404-3mw4q7m3 248 8 cell cell NN cord-323404-3mw4q7m3 248 9 - - HYPH cord-323404-3mw4q7m3 248 10 free free JJ cord-323404-3mw4q7m3 248 11 particles particle NNS cord-323404-3mw4q7m3 248 12 . . . cord-323404-3mw4q7m3 249 1 However however RB cord-323404-3mw4q7m3 249 2 , , , cord-323404-3mw4q7m3 249 3 the the DT cord-323404-3mw4q7m3 249 4 importance importance NN cord-323404-3mw4q7m3 249 5 of of IN cord-323404-3mw4q7m3 249 6 infected infected JJ cord-323404-3mw4q7m3 249 7 cells cell NNS cord-323404-3mw4q7m3 249 8 has have VBZ cord-323404-3mw4q7m3 249 9 been be VBN cord-323404-3mw4q7m3 249 10 revisited revisit VBN cord-323404-3mw4q7m3 249 11 . . . cord-323404-3mw4q7m3 250 1 It -PRON- PRP cord-323404-3mw4q7m3 250 2 is be VBZ cord-323404-3mw4q7m3 250 3 known know VBN cord-323404-3mw4q7m3 250 4 empirically empirically RB cord-323404-3mw4q7m3 250 5 that that IN cord-323404-3mw4q7m3 250 6 target target NN cord-323404-3mw4q7m3 250 7 - - HYPH cord-323404-3mw4q7m3 250 8 cell cell NN cord-323404-3mw4q7m3 250 9 infection infection NN cord-323404-3mw4q7m3 250 10 is be VBZ cord-323404-3mw4q7m3 250 11 usually usually RB cord-323404-3mw4q7m3 250 12 more more RBR cord-323404-3mw4q7m3 250 13 efficient efficient JJ cord-323404-3mw4q7m3 250 14 using use VBG cord-323404-3mw4q7m3 250 15 cell cell NN cord-323404-3mw4q7m3 250 16 - - HYPH cord-323404-3mw4q7m3 250 17 associated associate VBN cord-323404-3mw4q7m3 250 18 viruses virus NNS cord-323404-3mw4q7m3 250 19 , , , cord-323404-3mw4q7m3 250 20 but but CC cord-323404-3mw4q7m3 250 21 the the DT cord-323404-3mw4q7m3 250 22 mechanism mechanism NN cord-323404-3mw4q7m3 250 23 remains remain VBZ cord-323404-3mw4q7m3 250 24 unclear unclear JJ cord-323404-3mw4q7m3 250 25 . . . cord-323404-3mw4q7m3 251 1 Recent recent JJ cord-323404-3mw4q7m3 251 2 data datum NNS cord-323404-3mw4q7m3 251 3 on on IN cord-323404-3mw4q7m3 251 4 human human JJ cord-323404-3mw4q7m3 251 5 immunodeficiency immunodeficiency NN cord-323404-3mw4q7m3 251 6 virus virus NN cord-323404-3mw4q7m3 251 7 ( ( -LRB- cord-323404-3mw4q7m3 251 8 HIV HIV NNP cord-323404-3mw4q7m3 251 9 ) ) -RRB- cord-323404-3mw4q7m3 251 10 3 3 CD cord-323404-3mw4q7m3 251 11 , , , cord-323404-3mw4q7m3 251 12 91 91 CD cord-323404-3mw4q7m3 251 13 and and CC cord-323404-3mw4q7m3 251 14 Epstein Epstein NNP cord-323404-3mw4q7m3 251 15 - - HYPH cord-323404-3mw4q7m3 251 16 Barr Barr NNP cord-323404-3mw4q7m3 251 17 virus virus NN cord-323404-3mw4q7m3 251 18 ( ( -LRB- cord-323404-3mw4q7m3 251 19 EBV EBV NNP cord-323404-3mw4q7m3 251 20 ) ) -RRB- cord-323404-3mw4q7m3 251 21 92 92 CD cord-323404-3mw4q7m3 251 22 indicate indicate VBP cord-323404-3mw4q7m3 251 23 that that IN cord-323404-3mw4q7m3 251 24 , , , cord-323404-3mw4q7m3 251 25 by by IN cord-323404-3mw4q7m3 251 26 interacting interact VBG cord-323404-3mw4q7m3 251 27 with with IN cord-323404-3mw4q7m3 251 28 the the DT cord-323404-3mw4q7m3 251 29 epithelial epithelial JJ cord-323404-3mw4q7m3 251 30 target target NN cord-323404-3mw4q7m3 251 31 cell cell NN cord-323404-3mw4q7m3 251 32 , , , cord-323404-3mw4q7m3 251 33 infected infected JJ cord-323404-3mw4q7m3 251 34 cells cell NNS cord-323404-3mw4q7m3 251 35 might may MD cord-323404-3mw4q7m3 251 36 start start VB cord-323404-3mw4q7m3 251 37 to to IN cord-323404-3mw4q7m3 251 38 bud bud NN cord-323404-3mw4q7m3 251 39 newly newly RB cord-323404-3mw4q7m3 251 40 formed form VBN cord-323404-3mw4q7m3 251 41 cell cell NN cord-323404-3mw4q7m3 251 42 - - HYPH cord-323404-3mw4q7m3 251 43 free free JJ cord-323404-3mw4q7m3 251 44 viral viral JJ cord-323404-3mw4q7m3 251 45 particles particle NNS cord-323404-3mw4q7m3 251 46 . . . cord-323404-3mw4q7m3 252 1 These these DT cord-323404-3mw4q7m3 252 2 particles particle NNS cord-323404-3mw4q7m3 252 3 interact interact VBP cord-323404-3mw4q7m3 252 4 differently differently RB cord-323404-3mw4q7m3 252 5 with with IN cord-323404-3mw4q7m3 252 6 epithelial epithelial JJ cord-323404-3mw4q7m3 252 7 cells cell NNS cord-323404-3mw4q7m3 252 8 than than IN cord-323404-3mw4q7m3 252 9 does do VBZ cord-323404-3mw4q7m3 252 10 an an DT cord-323404-3mw4q7m3 252 11 isolated isolated JJ cord-323404-3mw4q7m3 252 12 cell cell NN cord-323404-3mw4q7m3 252 13 - - HYPH cord-323404-3mw4q7m3 252 14 free free JJ cord-323404-3mw4q7m3 252 15 virus virus NN cord-323404-3mw4q7m3 252 16 inoculum inoculum NN cord-323404-3mw4q7m3 252 17 . . . cord-323404-3mw4q7m3 253 1 This this DT cord-323404-3mw4q7m3 253 2 might may MD cord-323404-3mw4q7m3 253 3 be be VB cord-323404-3mw4q7m3 253 4 due due JJ cord-323404-3mw4q7m3 253 5 to to IN cord-323404-3mw4q7m3 253 6 the the DT cord-323404-3mw4q7m3 253 7 differences difference NNS cord-323404-3mw4q7m3 253 8 in in IN cord-323404-3mw4q7m3 253 9 the the DT cord-323404-3mw4q7m3 253 10 viral viral JJ cord-323404-3mw4q7m3 253 11 - - HYPH cord-323404-3mw4q7m3 253 12 envelope envelope NN cord-323404-3mw4q7m3 253 13 composition composition NN cord-323404-3mw4q7m3 253 14 or or CC cord-323404-3mw4q7m3 253 15 in in IN cord-323404-3mw4q7m3 253 16 the the DT cord-323404-3mw4q7m3 253 17 contact contact NN cord-323404-3mw4q7m3 253 18 between between IN cord-323404-3mw4q7m3 253 19 the the DT cord-323404-3mw4q7m3 253 20 infected infected JJ cord-323404-3mw4q7m3 253 21 cell cell NN cord-323404-3mw4q7m3 253 22 and and CC cord-323404-3mw4q7m3 253 23 epithelial epithelial JJ cord-323404-3mw4q7m3 253 24 cells cell NNS cord-323404-3mw4q7m3 253 25 . . . cord-323404-3mw4q7m3 254 1 ENTEROCYTE ENTEROCYTE NNP cord-323404-3mw4q7m3 255 1 An an DT cord-323404-3mw4q7m3 255 2 intestinal intestinal JJ cord-323404-3mw4q7m3 255 3 epithelial epithelial JJ cord-323404-3mw4q7m3 255 4 cell cell NN cord-323404-3mw4q7m3 255 5 that that WDT cord-323404-3mw4q7m3 255 6 is be VBZ cord-323404-3mw4q7m3 255 7 organized organize VBN cord-323404-3mw4q7m3 255 8 in in IN cord-323404-3mw4q7m3 255 9 monostratified monostratified JJ cord-323404-3mw4q7m3 255 10 layers layer NNS cord-323404-3mw4q7m3 255 11 . . . cord-323404-3mw4q7m3 256 1 family family NN cord-323404-3mw4q7m3 256 2 84 84 CD cord-323404-3mw4q7m3 256 3 , , , cord-323404-3mw4q7m3 256 4 85 85 CD cord-323404-3mw4q7m3 256 5 , , , cord-323404-3mw4q7m3 256 6 CD46 CD46 NNP cord-323404-3mw4q7m3 256 7 ( ( -LRB- cord-323404-3mw4q7m3 256 8 REF REF NNP cord-323404-3mw4q7m3 256 9 . . . cord-323404-3mw4q7m3 256 10 13 13 CD cord-323404-3mw4q7m3 256 11 ; ; : cord-323404-3mw4q7m3 256 12 together together RB cord-323404-3mw4q7m3 256 13 with with IN cord-323404-3mw4q7m3 256 14 its -PRON- PRP$ cord-323404-3mw4q7m3 256 15 co co JJ cord-323404-3mw4q7m3 256 16 - - NN cord-323404-3mw4q7m3 256 17 receptor receptor JJ cord-323404-3mw4q7m3 256 18 epithelial epithelial JJ cord-323404-3mw4q7m3 256 19 moesin moesin NNP cord-323404-3mw4q7m3 256 20 ) ) -RRB- cord-323404-3mw4q7m3 256 21 , , , cord-323404-3mw4q7m3 256 22 and and CC cord-323404-3mw4q7m3 256 23 the the DT cord-323404-3mw4q7m3 256 24 N n CD cord-323404-3mw4q7m3 256 25 - - HYPH cord-323404-3mw4q7m3 256 26 aminopeptidase aminopeptidase NN cord-323404-3mw4q7m3 256 27 CD13 CD13 NNP cord-323404-3mw4q7m3 256 28 ( ( -LRB- cord-323404-3mw4q7m3 256 29 REFS REFS NNP cord-323404-3mw4q7m3 256 30 12 12 CD cord-323404-3mw4q7m3 256 31 , , , cord-323404-3mw4q7m3 256 32 84 84 CD cord-323404-3mw4q7m3 256 33 ) ) -RRB- cord-323404-3mw4q7m3 256 34 , , , cord-323404-3mw4q7m3 256 35 which which WDT cord-323404-3mw4q7m3 256 36 can can MD cord-323404-3mw4q7m3 256 37 dimerize dimerize VB cord-323404-3mw4q7m3 256 38 and and CC cord-323404-3mw4q7m3 256 39 probably probably RB cord-323404-3mw4q7m3 256 40 transduce transduce VB cord-323404-3mw4q7m3 256 41 signals signal NNS cord-323404-3mw4q7m3 256 42 . . . cord-323404-3mw4q7m3 257 1 The the DT cord-323404-3mw4q7m3 257 2 glycosylphosphatidylinositol glycosylphosphatidylinositol NN cord-323404-3mw4q7m3 257 3 ( ( -LRB- cord-323404-3mw4q7m3 257 4 GPI)-anchored gpi)-anchore VBN cord-323404-3mw4q7m3 257 5 complement complement NN cord-323404-3mw4q7m3 257 6 regulatory regulatory JJ cord-323404-3mw4q7m3 257 7 protein protein NN cord-323404-3mw4q7m3 257 8 DAF DAF NNP cord-323404-3mw4q7m3 257 9 ( ( -LRB- cord-323404-3mw4q7m3 257 10 decay decay NN cord-323404-3mw4q7m3 257 11 acceleration acceleration NN cord-323404-3mw4q7m3 257 12 factor factor NN cord-323404-3mw4q7m3 257 13 ) ) -RRB- cord-323404-3mw4q7m3 257 14 is be VBZ cord-323404-3mw4q7m3 257 15 widely widely RB cord-323404-3mw4q7m3 257 16 used use VBN cord-323404-3mw4q7m3 257 17 by by IN cord-323404-3mw4q7m3 257 18 enteroviruses enteroviruses NNP cord-323404-3mw4q7m3 257 19 , , , cord-323404-3mw4q7m3 257 20 including include VBG cord-323404-3mw4q7m3 257 21 echoviruses echovirus NNS cord-323404-3mw4q7m3 257 22 , , , cord-323404-3mw4q7m3 257 23 human human JJ cord-323404-3mw4q7m3 257 24 enterovirus enterovirus NN cord-323404-3mw4q7m3 257 25 ( ( -LRB- cord-323404-3mw4q7m3 257 26 EV)-70 EV)-70 NNP cord-323404-3mw4q7m3 257 27 , , , cord-323404-3mw4q7m3 257 28 coxsackievirus coxsackievirus NNP cord-323404-3mw4q7m3 257 29 types type NNS cord-323404-3mw4q7m3 257 30 B B NNP cord-323404-3mw4q7m3 257 31 and and CC cord-323404-3mw4q7m3 257 32 A21 A21 NNP cord-323404-3mw4q7m3 257 33 ( ( -LRB- cord-323404-3mw4q7m3 257 34 REF ref NN cord-323404-3mw4q7m3 257 35 . . . cord-323404-3mw4q7m3 257 36 45 45 CD cord-323404-3mw4q7m3 257 37 ) ) -RRB- cord-323404-3mw4q7m3 257 38 , , , cord-323404-3mw4q7m3 257 39 as as RB cord-323404-3mw4q7m3 257 40 well well RB cord-323404-3mw4q7m3 257 41 as as IN cord-323404-3mw4q7m3 257 42 other other JJ cord-323404-3mw4q7m3 257 43 GPI GPI NNP cord-323404-3mw4q7m3 257 44 - - HYPH cord-323404-3mw4q7m3 257 45 anchored anchor VBN cord-323404-3mw4q7m3 257 46 proteins protein NNS cord-323404-3mw4q7m3 257 47 . . . cord-323404-3mw4q7m3 258 1 These these DT cord-323404-3mw4q7m3 258 2 GPI GPI NNP cord-323404-3mw4q7m3 258 3 - - HYPH cord-323404-3mw4q7m3 258 4 anchored anchor VBN cord-323404-3mw4q7m3 258 5 proteins protein NNS cord-323404-3mw4q7m3 258 6 , , , cord-323404-3mw4q7m3 258 7 which which WDT cord-323404-3mw4q7m3 258 8 are be VBP cord-323404-3mw4q7m3 258 9 localized localize VBN cord-323404-3mw4q7m3 258 10 in in IN cord-323404-3mw4q7m3 258 11 apical apical JJ cord-323404-3mw4q7m3 258 12 rafts raft NNS cord-323404-3mw4q7m3 258 13 , , , cord-323404-3mw4q7m3 258 14 can can MD cord-323404-3mw4q7m3 258 15 be be VB cord-323404-3mw4q7m3 258 16 endocytosed endocytose VBN cord-323404-3mw4q7m3 258 17 by by IN cord-323404-3mw4q7m3 258 18 a a DT cord-323404-3mw4q7m3 258 19 Rho Rho NNP cord-323404-3mw4q7m3 258 20 - - HYPH cord-323404-3mw4q7m3 258 21 GTPase gtpase NN cord-323404-3mw4q7m3 258 22 - - HYPH cord-323404-3mw4q7m3 258 23 dependent dependent JJ cord-323404-3mw4q7m3 258 24 mechanism mechanism NN cord-323404-3mw4q7m3 258 25 ( ( -LRB- cord-323404-3mw4q7m3 258 26 FIG fig NN cord-323404-3mw4q7m3 258 27 . . . cord-323404-3mw4q7m3 258 28 1 1 CD cord-323404-3mw4q7m3 258 29 ) ) -RRB- cord-323404-3mw4q7m3 258 30 . . . cord-323404-3mw4q7m3 259 1 So so RB cord-323404-3mw4q7m3 259 2 , , , cord-323404-3mw4q7m3 259 3 as as IN cord-323404-3mw4q7m3 259 4 shown show VBN cord-323404-3mw4q7m3 259 5 recently recently RB cord-323404-3mw4q7m3 259 6 for for IN cord-323404-3mw4q7m3 259 7 E-11 E-11 NNP cord-323404-3mw4q7m3 259 8 , , , cord-323404-3mw4q7m3 259 9 they -PRON- PRP cord-323404-3mw4q7m3 259 10 can can MD cord-323404-3mw4q7m3 259 11 mediate mediate VB cord-323404-3mw4q7m3 259 12 internalization internalization NN cord-323404-3mw4q7m3 259 13 of of IN cord-323404-3mw4q7m3 259 14 the the DT cord-323404-3mw4q7m3 259 15 virus virus NN cord-323404-3mw4q7m3 259 16 in in IN cord-323404-3mw4q7m3 259 17 the the DT cord-323404-3mw4q7m3 259 18 endosome endosome NN cord-323404-3mw4q7m3 259 19 before before IN cord-323404-3mw4q7m3 259 20 translocation translocation NN cord-323404-3mw4q7m3 259 21 into into IN cord-323404-3mw4q7m3 259 22 the the DT cord-323404-3mw4q7m3 259 23 epithelial epithelial JJ cord-323404-3mw4q7m3 259 24 - - HYPH cord-323404-3mw4q7m3 259 25 cell cell NN cord-323404-3mw4q7m3 259 26 cytosol cytosol NN cord-323404-3mw4q7m3 259 27 45 45 CD cord-323404-3mw4q7m3 259 28 . . . cord-323404-3mw4q7m3 260 1 Molecules molecule NNS cord-323404-3mw4q7m3 260 2 that that WDT cord-323404-3mw4q7m3 260 3 are be VBP cord-323404-3mw4q7m3 260 4 expressed express VBN cord-323404-3mw4q7m3 260 5 basolaterally basolaterally NNS cord-323404-3mw4q7m3 260 6 include include VB cord-323404-3mw4q7m3 260 7 the the DT cord-323404-3mw4q7m3 260 8 transferrin transferrin NN cord-323404-3mw4q7m3 260 9 receptor receptor NN cord-323404-3mw4q7m3 260 10 . . . cord-323404-3mw4q7m3 261 1 By by IN cord-323404-3mw4q7m3 261 2 contrast contrast NN cord-323404-3mw4q7m3 261 3 , , , cord-323404-3mw4q7m3 261 4 viruses virus NNS cord-323404-3mw4q7m3 261 5 can can MD cord-323404-3mw4q7m3 261 6 use use VB cord-323404-3mw4q7m3 261 7 non non JJ cord-323404-3mw4q7m3 261 8 - - JJ cord-323404-3mw4q7m3 261 9 polarized polarized JJ cord-323404-3mw4q7m3 261 10 protein protein NN cord-323404-3mw4q7m3 261 11 receptors receptor NNS cord-323404-3mw4q7m3 261 12 27 27 CD cord-323404-3mw4q7m3 261 13 , , , cord-323404-3mw4q7m3 261 14 and and CC cord-323404-3mw4q7m3 261 15 so so RB cord-323404-3mw4q7m3 261 16 they -PRON- PRP cord-323404-3mw4q7m3 261 17 need need VBP cord-323404-3mw4q7m3 261 18 a a DT cord-323404-3mw4q7m3 261 19 polarized polarized JJ cord-323404-3mw4q7m3 261 20 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 261 21 co co NN cord-323404-3mw4q7m3 261 22 - - NN cord-323404-3mw4q7m3 261 23 receptor receptor NN cord-323404-3mw4q7m3 261 24 for for IN cord-323404-3mw4q7m3 261 25 entry entry NN cord-323404-3mw4q7m3 261 26 . . . cord-323404-3mw4q7m3 262 1 The the DT cord-323404-3mw4q7m3 262 2 interaction interaction NN cord-323404-3mw4q7m3 262 3 between between IN cord-323404-3mw4q7m3 262 4 a a DT cord-323404-3mw4q7m3 262 5 cellular cellular JJ cord-323404-3mw4q7m3 262 6 host host NN cord-323404-3mw4q7m3 262 7 and and CC cord-323404-3mw4q7m3 262 8 a a DT cord-323404-3mw4q7m3 262 9 viral viral JJ cord-323404-3mw4q7m3 262 10 pathogen pathogen NN cord-323404-3mw4q7m3 262 11 is be VBZ cord-323404-3mw4q7m3 262 12 an an DT cord-323404-3mw4q7m3 262 13 important important JJ cord-323404-3mw4q7m3 262 14 field field NN cord-323404-3mw4q7m3 262 15 of of IN cord-323404-3mw4q7m3 262 16 research research NN cord-323404-3mw4q7m3 262 17 , , , cord-323404-3mw4q7m3 262 18 both both CC cord-323404-3mw4q7m3 262 19 for for IN cord-323404-3mw4q7m3 262 20 unravelling unravel VBG cord-323404-3mw4q7m3 262 21 polarized polarized JJ cord-323404-3mw4q7m3 262 22 membrane membrane NN cord-323404-3mw4q7m3 262 23 trafficking traffic VBG cord-323404-3mw4q7m3 262 24 86 86 CD cord-323404-3mw4q7m3 262 25 and and CC cord-323404-3mw4q7m3 262 26 for for IN cord-323404-3mw4q7m3 262 27 understanding understand VBG cord-323404-3mw4q7m3 262 28 epithelial epithelial JJ cord-323404-3mw4q7m3 262 29 pathology pathology NN cord-323404-3mw4q7m3 262 30 ( ( -LRB- cord-323404-3mw4q7m3 262 31 for for IN cord-323404-3mw4q7m3 262 32 example example NN cord-323404-3mw4q7m3 262 33 , , , cord-323404-3mw4q7m3 262 34 see see VB cord-323404-3mw4q7m3 262 35 contrast contrast NN cord-323404-3mw4q7m3 262 36 , , , cord-323404-3mw4q7m3 262 37 the the DT cord-323404-3mw4q7m3 262 38 terminal terminal JJ cord-323404-3mw4q7m3 262 39 knob knob NN cord-323404-3mw4q7m3 262 40 portion portion NN cord-323404-3mw4q7m3 262 41 of of IN cord-323404-3mw4q7m3 262 42 the the DT cord-323404-3mw4q7m3 262 43 fibre fibre NN cord-323404-3mw4q7m3 262 44 protein protein NN cord-323404-3mw4q7m3 262 45 of of IN cord-323404-3mw4q7m3 262 46 human human JJ cord-323404-3mw4q7m3 262 47 adenovirus adenovirus NN cord-323404-3mw4q7m3 262 48 ( ( -LRB- cord-323404-3mw4q7m3 262 49 HAdV)-2 HAdV)-2 NNP cord-323404-3mw4q7m3 262 50 ( ( -LRB- cord-323404-3mw4q7m3 262 51 REF REF NNP cord-323404-3mw4q7m3 262 52 . . . cord-323404-3mw4q7m3 262 53 68 68 CD cord-323404-3mw4q7m3 262 54 ) ) -RRB- cord-323404-3mw4q7m3 262 55 binds bind VBZ cord-323404-3mw4q7m3 262 56 to to IN cord-323404-3mw4q7m3 262 57 CAR car NN cord-323404-3mw4q7m3 262 58 . . . cord-323404-3mw4q7m3 263 1 This this DT cord-323404-3mw4q7m3 263 2 allows allow VBZ cord-323404-3mw4q7m3 263 3 the the DT cord-323404-3mw4q7m3 263 4 viral viral JJ cord-323404-3mw4q7m3 263 5 capsid capsid NN cord-323404-3mw4q7m3 263 6 penton penton NNP cord-323404-3mw4q7m3 263 7 base base NNP cord-323404-3mw4q7m3 263 8 protein protein NNP cord-323404-3mw4q7m3 263 9 to to TO cord-323404-3mw4q7m3 263 10 bind bind VB cord-323404-3mw4q7m3 263 11 cell cell NN cord-323404-3mw4q7m3 263 12 - - HYPH cord-323404-3mw4q7m3 263 13 surface surface NN cord-323404-3mw4q7m3 263 14 integrin integrin NN cord-323404-3mw4q7m3 263 15 - - : cord-323404-3mw4q7m3 263 16 α α NN cord-323404-3mw4q7m3 263 17 v v NN cord-323404-3mw4q7m3 263 18 β β NN cord-323404-3mw4q7m3 263 19 5 5 CD cord-323404-3mw4q7m3 263 20 and and CC cord-323404-3mw4q7m3 263 21 its -PRON- PRP$ cord-323404-3mw4q7m3 263 22 subsequent subsequent JJ cord-323404-3mw4q7m3 263 23 endocytosis endocytosis NN cord-323404-3mw4q7m3 263 24 in in IN cord-323404-3mw4q7m3 263 25 clathrin clathrin NN cord-323404-3mw4q7m3 263 26 - - HYPH cord-323404-3mw4q7m3 263 27 coated coat VBN cord-323404-3mw4q7m3 263 28 vesicles vesicle NNS cord-323404-3mw4q7m3 263 29 79 79 CD cord-323404-3mw4q7m3 263 30 . . . cord-323404-3mw4q7m3 264 1 Nectin Nectin NNS cord-323404-3mw4q7m3 264 2 1 1 CD cord-323404-3mw4q7m3 264 3 ( ( -LRB- cord-323404-3mw4q7m3 264 4 also also RB cord-323404-3mw4q7m3 264 5 known know VBN cord-323404-3mw4q7m3 264 6 as as IN cord-323404-3mw4q7m3 264 7 poliovirus poliovirus NN cord-323404-3mw4q7m3 264 8 - - HYPH cord-323404-3mw4q7m3 264 9 related relate VBN cord-323404-3mw4q7m3 264 10 protein protein NN cord-323404-3mw4q7m3 264 11 1 1 CD cord-323404-3mw4q7m3 264 12 or or CC cord-323404-3mw4q7m3 264 13 HveC HveC NNP cord-323404-3mw4q7m3 264 14 ) ) -RRB- cord-323404-3mw4q7m3 264 15 is be VBZ cord-323404-3mw4q7m3 264 16 a a DT cord-323404-3mw4q7m3 264 17 Ca Ca NNP cord-323404-3mw4q7m3 264 18 2 2 CD cord-323404-3mw4q7m3 264 19 + + CD cord-323404-3mw4q7m3 264 20 -independent -independent JJ cord-323404-3mw4q7m3 264 21 cell cell NN cord-323404-3mw4q7m3 264 22 - - HYPH cord-323404-3mw4q7m3 264 23 adhesion adhesion NN cord-323404-3mw4q7m3 264 24 molecule molecule NN cord-323404-3mw4q7m3 264 25 that that WDT cord-323404-3mw4q7m3 264 26 is be VBZ cord-323404-3mw4q7m3 264 27 localized localize VBN cord-323404-3mw4q7m3 264 28 at at IN cord-323404-3mw4q7m3 264 29 cadherin cadherin NN cord-323404-3mw4q7m3 264 30 - - HYPH cord-323404-3mw4q7m3 264 31 based base VBN cord-323404-3mw4q7m3 264 32 intercellular intercellular JJ cord-323404-3mw4q7m3 264 33 junctions junction NNS cord-323404-3mw4q7m3 264 34 . . . cord-323404-3mw4q7m3 265 1 It -PRON- PRP cord-323404-3mw4q7m3 265 2 is be VBZ cord-323404-3mw4q7m3 265 3 used use VBN cord-323404-3mw4q7m3 265 4 by by IN cord-323404-3mw4q7m3 265 5 α α NN cord-323404-3mw4q7m3 265 6 - - HYPH cord-323404-3mw4q7m3 265 7 HSV-1 hsv-1 NN cord-323404-3mw4q7m3 265 8 and and CC cord-323404-3mw4q7m3 265 9 α α NN cord-323404-3mw4q7m3 265 10 - - HYPH cord-323404-3mw4q7m3 265 11 HSV-2 HSV-2 NNP cord-323404-3mw4q7m3 265 12 for for IN cord-323404-3mw4q7m3 265 13 entry entry NN cord-323404-3mw4q7m3 265 14 and and CC cord-323404-3mw4q7m3 265 15 infection infection NN cord-323404-3mw4q7m3 265 16 83 83 CD cord-323404-3mw4q7m3 265 17 after after IN cord-323404-3mw4q7m3 265 18 attachment attachment NN cord-323404-3mw4q7m3 265 19 to to IN cord-323404-3mw4q7m3 265 20 epithelialcell epithelialcell NNP cord-323404-3mw4q7m3 265 21 heparan heparan NN cord-323404-3mw4q7m3 265 22 sulphate sulphate NN cord-323404-3mw4q7m3 265 23 proteoglycan proteoglycan NN cord-323404-3mw4q7m3 265 24 . . . cord-323404-3mw4q7m3 266 1 In in IN cord-323404-3mw4q7m3 266 2 reovirus reovirus JJ cord-323404-3mw4q7m3 266 3 infection infection NN cord-323404-3mw4q7m3 266 4 , , , cord-323404-3mw4q7m3 266 5 human human JJ cord-323404-3mw4q7m3 266 6 JAM jam NN cord-323404-3mw4q7m3 266 7 -an -an : cord-323404-3mw4q7m3 266 8 integral integral JJ cord-323404-3mw4q7m3 266 9 membrane membrane NN cord-323404-3mw4q7m3 266 10 protein protein NN cord-323404-3mw4q7m3 266 11 that that WDT cord-323404-3mw4q7m3 266 12 organizes organize VBZ cord-323404-3mw4q7m3 266 13 the the DT cord-323404-3mw4q7m3 266 14 tight tight JJ cord-323404-3mw4q7m3 266 15 junctions junction NNS cord-323404-3mw4q7m3 266 16 of of IN cord-323404-3mw4q7m3 266 17 epithelial epithelial JJ cord-323404-3mw4q7m3 266 18 cellsbinds cellsbind NNS cord-323404-3mw4q7m3 266 19 the the DT cord-323404-3mw4q7m3 266 20 head head NN cord-323404-3mw4q7m3 266 21 domain domain NN cord-323404-3mw4q7m3 266 22 of of IN cord-323404-3mw4q7m3 266 23 the the DT cord-323404-3mw4q7m3 266 24 viral viral JJ cord-323404-3mw4q7m3 266 25 σ1 σ1 NNP cord-323404-3mw4q7m3 266 26 outer outer RB cord-323404-3mw4q7m3 266 27 - - HYPH cord-323404-3mw4q7m3 266 28 capsid capsid NN cord-323404-3mw4q7m3 266 29 protein protein NN cord-323404-3mw4q7m3 266 30 . . . cord-323404-3mw4q7m3 267 1 It -PRON- PRP cord-323404-3mw4q7m3 267 2 binds bind VBZ cord-323404-3mw4q7m3 267 3 at at IN cord-323404-3mw4q7m3 267 4 the the DT cord-323404-3mw4q7m3 267 5 basolateral basolateral JJ cord-323404-3mw4q7m3 267 6 ( ( -LRB- cord-323404-3mw4q7m3 267 7 serosal serosal NNP cord-323404-3mw4q7m3 267 8 ) ) -RRB- cord-323404-3mw4q7m3 267 9 pole pole NN cord-323404-3mw4q7m3 267 10 of of IN cord-323404-3mw4q7m3 267 11 the the DT cord-323404-3mw4q7m3 267 12 epithelial epithelial JJ cord-323404-3mw4q7m3 267 13 layer layer NN cord-323404-3mw4q7m3 267 14 , , , cord-323404-3mw4q7m3 267 15 after after IN cord-323404-3mw4q7m3 267 16 reovirus reovirus NNP cord-323404-3mw4q7m3 267 17 has have VBZ cord-323404-3mw4q7m3 267 18 undergone undergo VBN cord-323404-3mw4q7m3 267 19 transcytosis transcytosis NN cord-323404-3mw4q7m3 267 20 across across IN cord-323404-3mw4q7m3 267 21 M M NNP cord-323404-3mw4q7m3 267 22 cells cell NNS cord-323404-3mw4q7m3 267 23 11 11 CD cord-323404-3mw4q7m3 267 24 . . . cord-323404-3mw4q7m3 268 1 JAM jam NN cord-323404-3mw4q7m3 268 2 functions function NNS cord-323404-3mw4q7m3 268 3 as as IN cord-323404-3mw4q7m3 268 4 a a DT cord-323404-3mw4q7m3 268 5 serotype serotype NN cord-323404-3mw4q7m3 268 6 - - HYPH cord-323404-3mw4q7m3 268 7 independent independent JJ cord-323404-3mw4q7m3 268 8 receptor receptor NN cord-323404-3mw4q7m3 268 9 that that WDT cord-323404-3mw4q7m3 268 10 can can MD cord-323404-3mw4q7m3 268 11 mediate mediate VB cord-323404-3mw4q7m3 268 12 virus virus NN cord-323404-3mw4q7m3 268 13 attachment attachment NN cord-323404-3mw4q7m3 268 14 and and CC cord-323404-3mw4q7m3 268 15 infection infection NN cord-323404-3mw4q7m3 268 16 69 69 CD cord-323404-3mw4q7m3 268 17 . . . cord-323404-3mw4q7m3 269 1 Other other JJ cord-323404-3mw4q7m3 269 2 classes class NNS cord-323404-3mw4q7m3 269 3 of of IN cord-323404-3mw4q7m3 269 4 polarized polarized JJ cord-323404-3mw4q7m3 269 5 receptor receptor NN cord-323404-3mw4q7m3 269 6 . . . cord-323404-3mw4q7m3 270 1 Several several JJ cord-323404-3mw4q7m3 270 2 protein protein NN cord-323404-3mw4q7m3 270 3 receptors receptor NNS cord-323404-3mw4q7m3 270 4 have have VBP cord-323404-3mw4q7m3 270 5 a a DT cord-323404-3mw4q7m3 270 6 polarized polarized JJ cord-323404-3mw4q7m3 270 7 distribution distribution NN cord-323404-3mw4q7m3 270 8 , , , cord-323404-3mw4q7m3 270 9 which which WDT cord-323404-3mw4q7m3 270 10 allows allow VBZ cord-323404-3mw4q7m3 270 11 viral viral JJ cord-323404-3mw4q7m3 270 12 entry entry NN cord-323404-3mw4q7m3 270 13 into into IN cord-323404-3mw4q7m3 270 14 epithelial epithelial JJ cord-323404-3mw4q7m3 270 15 cells cell NNS cord-323404-3mw4q7m3 270 16 , , , cord-323404-3mw4q7m3 270 17 or or CC cord-323404-3mw4q7m3 270 18 cell cell NN cord-323404-3mw4q7m3 270 19 resistance resistance NN cord-323404-3mw4q7m3 270 20 to to IN cord-323404-3mw4q7m3 270 21 infection infection NN cord-323404-3mw4q7m3 270 22 when when WRB cord-323404-3mw4q7m3 270 23 a a DT cord-323404-3mw4q7m3 270 24 virus virus NN cord-323404-3mw4q7m3 270 25 enters enter VBZ cord-323404-3mw4q7m3 270 26 epithelial epithelial JJ cord-323404-3mw4q7m3 270 27 cells cell NNS cord-323404-3mw4q7m3 270 28 by by IN cord-323404-3mw4q7m3 270 29 the the DT cord-323404-3mw4q7m3 270 30 opposite opposite JJ cord-323404-3mw4q7m3 270 31 pole pole NN cord-323404-3mw4q7m3 270 32 . . . cord-323404-3mw4q7m3 271 1 Apical apical JJ cord-323404-3mw4q7m3 271 2 viral viral JJ cord-323404-3mw4q7m3 271 3 receptors receptor NNS cord-323404-3mw4q7m3 271 4 include include VBP cord-323404-3mw4q7m3 271 5 the the DT cord-323404-3mw4q7m3 271 6 carcino carcino NN cord-323404-3mw4q7m3 271 7 - - HYPH cord-323404-3mw4q7m3 271 8 embryonic embryonic JJ cord-323404-3mw4q7m3 271 9 antigen antigen NN cord-323404-3mw4q7m3 271 10 During during IN cord-323404-3mw4q7m3 271 11 the the DT cord-323404-3mw4q7m3 271 12 first first JJ cord-323404-3mw4q7m3 271 13 cycle cycle NN cord-323404-3mw4q7m3 271 14 of of IN cord-323404-3mw4q7m3 271 15 rotavirus rotavirus JJ cord-323404-3mw4q7m3 271 16 replication replication NN cord-323404-3mw4q7m3 271 17 in in IN cord-323404-3mw4q7m3 271 18 mucosal mucosal JJ cord-323404-3mw4q7m3 271 19 epithelial epithelial JJ cord-323404-3mw4q7m3 271 20 cells cell NNS cord-323404-3mw4q7m3 271 21 , , , cord-323404-3mw4q7m3 271 22 the the DT cord-323404-3mw4q7m3 271 23 synthesis synthesis NN cord-323404-3mw4q7m3 271 24 of of IN cord-323404-3mw4q7m3 271 25 rotaviral rotaviral JJ cord-323404-3mw4q7m3 271 26 proteins protein NNS cord-323404-3mw4q7m3 271 27 in in IN cord-323404-3mw4q7m3 271 28 the the DT cord-323404-3mw4q7m3 271 29 cell cell NN cord-323404-3mw4q7m3 271 30 cytoplasm cytoplasm NN cord-323404-3mw4q7m3 271 31 leads lead VBZ cord-323404-3mw4q7m3 271 32 to to IN cord-323404-3mw4q7m3 271 33 an an DT cord-323404-3mw4q7m3 271 34 increase increase NN cord-323404-3mw4q7m3 271 35 in in IN cord-323404-3mw4q7m3 271 36 the the DT cord-323404-3mw4q7m3 271 37 plasma plasma NN cord-323404-3mw4q7m3 271 38 - - HYPH cord-323404-3mw4q7m3 271 39 membrane membrane NN cord-323404-3mw4q7m3 271 40 permeability permeability NN cord-323404-3mw4q7m3 271 41 to to IN cord-323404-3mw4q7m3 271 42 Ca Ca NNP cord-323404-3mw4q7m3 271 43 2 2 CD cord-323404-3mw4q7m3 271 44 + + CC cord-323404-3mw4q7m3 271 45 , , , cord-323404-3mw4q7m3 271 46 to to TO cord-323404-3mw4q7m3 271 47 activation activation NN cord-323404-3mw4q7m3 271 48 of of IN cord-323404-3mw4q7m3 271 49 regulatory regulatory JJ cord-323404-3mw4q7m3 271 50 mechanisms mechanism NNS cord-323404-3mw4q7m3 271 51 and and CC cord-323404-3mw4q7m3 271 52 to to IN cord-323404-3mw4q7m3 271 53 an an DT cord-323404-3mw4q7m3 271 54 increase increase NN cord-323404-3mw4q7m3 271 55 in in IN cord-323404-3mw4q7m3 271 56 the the DT cord-323404-3mw4q7m3 271 57 concentration concentration NN cord-323404-3mw4q7m3 271 58 of of IN cord-323404-3mw4q7m3 271 59 Ca Ca NNP cord-323404-3mw4q7m3 271 60 2 2 CD cord-323404-3mw4q7m3 271 61 + + CC cord-323404-3mw4q7m3 271 62 in in IN cord-323404-3mw4q7m3 271 63 the the DT cord-323404-3mw4q7m3 271 64 endoplasmic endoplasmic NN cord-323404-3mw4q7m3 271 65 reticulum reticulum NN cord-323404-3mw4q7m3 271 66 ( ( -LRB- cord-323404-3mw4q7m3 271 67 ER ER NNP cord-323404-3mw4q7m3 271 68 ) ) -RRB- cord-323404-3mw4q7m3 271 69 . . . cord-323404-3mw4q7m3 272 1 The the DT cord-323404-3mw4q7m3 272 2 increased increase VBN cord-323404-3mw4q7m3 272 3 concentration concentration NN cord-323404-3mw4q7m3 272 4 of of IN cord-323404-3mw4q7m3 272 5 cytosolic cytosolic JJ cord-323404-3mw4q7m3 272 6 Ca Ca NNP cord-323404-3mw4q7m3 272 7 2 2 CD cord-323404-3mw4q7m3 272 8 + + CC cord-323404-3mw4q7m3 272 9 in in IN cord-323404-3mw4q7m3 272 10 infected infected JJ cord-323404-3mw4q7m3 272 11 cells cell NNS cord-323404-3mw4q7m3 272 12 promotes promote VBZ cord-323404-3mw4q7m3 272 13 the the DT cord-323404-3mw4q7m3 272 14 activation activation NN cord-323404-3mw4q7m3 272 15 of of IN cord-323404-3mw4q7m3 272 16 Ca Ca NNP cord-323404-3mw4q7m3 272 17 2 2 CD cord-323404-3mw4q7m3 272 18 + + SYM cord-323404-3mw4q7m3 272 19 -dependent -dependent JJ cord-323404-3mw4q7m3 272 20 enzymes enzyme NNS cord-323404-3mw4q7m3 272 21 , , , cord-323404-3mw4q7m3 272 22 which which WDT cord-323404-3mw4q7m3 272 23 in in IN cord-323404-3mw4q7m3 272 24 turn turn NN cord-323404-3mw4q7m3 272 25 induces induce VBZ cord-323404-3mw4q7m3 272 26 cell cell NN cord-323404-3mw4q7m3 272 27 lysis lysis NN cord-323404-3mw4q7m3 272 28 and and CC cord-323404-3mw4q7m3 272 29 the the DT cord-323404-3mw4q7m3 272 30 release release NN cord-323404-3mw4q7m3 272 31 of of IN cord-323404-3mw4q7m3 272 32 viral viral JJ cord-323404-3mw4q7m3 272 33 proteins protein NNS cord-323404-3mw4q7m3 272 34 and and CC cord-323404-3mw4q7m3 272 35 viral viral JJ cord-323404-3mw4q7m3 272 36 progeny progeny NN cord-323404-3mw4q7m3 272 37 . . . cord-323404-3mw4q7m3 273 1 Non non JJ cord-323404-3mw4q7m3 273 2 - - JJ cord-323404-3mw4q7m3 273 3 structural structural JJ cord-323404-3mw4q7m3 273 4 protein protein NN cord-323404-3mw4q7m3 273 5 ( ( -LRB- cord-323404-3mw4q7m3 273 6 NSP)-4 NSP)-4 NNP cord-323404-3mw4q7m3 273 7 might may MD cord-323404-3mw4q7m3 273 8 act act VB cord-323404-3mw4q7m3 273 9 as as IN cord-323404-3mw4q7m3 273 10 a a DT cord-323404-3mw4q7m3 273 11 viral viral JJ cord-323404-3mw4q7m3 273 12 enterotoxin enterotoxin NN cord-323404-3mw4q7m3 273 13 on on IN cord-323404-3mw4q7m3 273 14 as as IN cord-323404-3mw4q7m3 273 15 - - HYPH cord-323404-3mw4q7m3 273 16 yet yet RB cord-323404-3mw4q7m3 273 17 - - HYPH cord-323404-3mw4q7m3 273 18 uninfected uninfected JJ cord-323404-3mw4q7m3 273 19 cells cell NNS cord-323404-3mw4q7m3 273 20 to to TO cord-323404-3mw4q7m3 273 21 induce induce VB cord-323404-3mw4q7m3 273 22 secretory secretory JJ cord-323404-3mw4q7m3 273 23 diarrhoea diarrhoea NN cord-323404-3mw4q7m3 273 24 through through IN cord-323404-3mw4q7m3 273 25 a a DT cord-323404-3mw4q7m3 273 26 | | CD cord-323404-3mw4q7m3 274 1 Ca ca NN cord-323404-3mw4q7m3 274 2 2 2 CD cord-323404-3mw4q7m3 274 3 + + CD cord-323404-3mw4q7m3 275 1 -dependent -dependent JJ cord-323404-3mw4q7m3 276 1 secretion secretion NN cord-323404-3mw4q7m3 276 2 by by IN cord-323404-3mw4q7m3 276 3 intestinal intestinal JJ cord-323404-3mw4q7m3 276 4 cells cell NNS cord-323404-3mw4q7m3 276 5 , , , cord-323404-3mw4q7m3 276 6 b b NN cord-323404-3mw4q7m3 276 7 | | CD cord-323404-3mw4q7m3 277 1 Ca ca NN cord-323404-3mw4q7m3 277 2 2 2 CD cord-323404-3mw4q7m3 277 3 + + CD cord-323404-3mw4q7m3 278 1 -dependent -dependent JJ cord-323404-3mw4q7m3 278 2 secretion secretion NN cord-323404-3mw4q7m3 278 3 of of IN cord-323404-3mw4q7m3 278 4 peptides peptide NNS cord-323404-3mw4q7m3 278 5 and and CC cord-323404-3mw4q7m3 278 6 amines amine NNS cord-323404-3mw4q7m3 278 7 to to TO cord-323404-3mw4q7m3 278 8 stimulate stimulate VB cord-323404-3mw4q7m3 278 9 the the DT cord-323404-3mw4q7m3 278 10 enteric enteric JJ cord-323404-3mw4q7m3 278 11 nervous nervous JJ cord-323404-3mw4q7m3 278 12 system system NN cord-323404-3mw4q7m3 278 13 ( ( -LRB- cord-323404-3mw4q7m3 278 14 ENS ENS NNP cord-323404-3mw4q7m3 278 15 ) ) -RRB- cord-323404-3mw4q7m3 278 16 , , , cord-323404-3mw4q7m3 278 17 and and CC cord-323404-3mw4q7m3 278 18 c c NN cord-323404-3mw4q7m3 278 19 | | NNP cord-323404-3mw4q7m3 278 20 further further JJ cord-323404-3mw4q7m3 278 21 activation activation NN cord-323404-3mw4q7m3 278 22 of of IN cord-323404-3mw4q7m3 278 23 epithelial epithelial JJ cord-323404-3mw4q7m3 278 24 - - HYPH cord-323404-3mw4q7m3 278 25 cell cell NN cord-323404-3mw4q7m3 278 26 chloride chloride NN cord-323404-3mw4q7m3 278 27 ( ( -LRB- cord-323404-3mw4q7m3 278 28 Cl Cl NNP cord-323404-3mw4q7m3 278 29 - - HYPH cord-323404-3mw4q7m3 278 30 ) ) -RRB- cord-323404-3mw4q7m3 278 31 secretion secretion NN cord-323404-3mw4q7m3 278 32 by by IN cord-323404-3mw4q7m3 278 33 the the DT cord-323404-3mw4q7m3 278 34 ENS ENS NNP cord-323404-3mw4q7m3 278 35 . . . cord-323404-3mw4q7m3 279 1 In in IN cord-323404-3mw4q7m3 279 2 parallel parallel NN cord-323404-3mw4q7m3 279 3 , , , cord-323404-3mw4q7m3 279 4 released release VBN cord-323404-3mw4q7m3 279 5 virus virus NN cord-323404-3mw4q7m3 279 6 infects infect VBZ cord-323404-3mw4q7m3 279 7 downstream downstream JJ cord-323404-3mw4q7m3 279 8 absorptive absorptive JJ cord-323404-3mw4q7m3 279 9 cells cell NNS cord-323404-3mw4q7m3 279 10 . . . cord-323404-3mw4q7m3 280 1 This this DT cord-323404-3mw4q7m3 280 2 will will MD cord-323404-3mw4q7m3 280 3 lead lead VB cord-323404-3mw4q7m3 280 4 to to IN cord-323404-3mw4q7m3 280 5 a a DT cord-323404-3mw4q7m3 280 6 massive massive JJ cord-323404-3mw4q7m3 280 7 cell cell NN cord-323404-3mw4q7m3 280 8 death death NN cord-323404-3mw4q7m3 280 9 and and CC cord-323404-3mw4q7m3 280 10 , , , cord-323404-3mw4q7m3 280 11 as as IN cord-323404-3mw4q7m3 280 12 a a DT cord-323404-3mw4q7m3 280 13 consequence consequence NN cord-323404-3mw4q7m3 280 14 , , , cord-323404-3mw4q7m3 280 15 reduction reduction NN cord-323404-3mw4q7m3 280 16 of of IN cord-323404-3mw4q7m3 280 17 the the DT cord-323404-3mw4q7m3 280 18 absorptive absorptive JJ cord-323404-3mw4q7m3 280 19 surface surface NN cord-323404-3mw4q7m3 280 20 of of IN cord-323404-3mw4q7m3 280 21 the the DT cord-323404-3mw4q7m3 280 22 intestinal intestinal JJ cord-323404-3mw4q7m3 280 23 epithelium epithelium NN cord-323404-3mw4q7m3 280 24 and and CC cord-323404-3mw4q7m3 280 25 an an DT cord-323404-3mw4q7m3 280 26 osmotic osmotic JJ cord-323404-3mw4q7m3 280 27 component component NN cord-323404-3mw4q7m3 280 28 of of IN cord-323404-3mw4q7m3 280 29 diarrhoea diarrhoea NN cord-323404-3mw4q7m3 280 30 42 42 CD cord-323404-3mw4q7m3 280 31 . . . cord-323404-3mw4q7m3 281 1 Various various JJ cord-323404-3mw4q7m3 281 2 forms form NNS cord-323404-3mw4q7m3 281 3 of of IN cord-323404-3mw4q7m3 281 4 the the DT cord-323404-3mw4q7m3 281 5 virus virus NN cord-323404-3mw4q7m3 281 6 along along IN cord-323404-3mw4q7m3 281 7 the the DT cord-323404-3mw4q7m3 281 8 rotavirus rotavirus JJ cord-323404-3mw4q7m3 281 9 - - HYPH cord-323404-3mw4q7m3 281 10 maturation maturation NN cord-323404-3mw4q7m3 281 11 pathway pathway NN cord-323404-3mw4q7m3 281 12 are be VBP cord-323404-3mw4q7m3 281 13 shown show VBN cord-323404-3mw4q7m3 281 14 : : : cord-323404-3mw4q7m3 281 15 DLP DLP NNP cord-323404-3mw4q7m3 281 16 , , , cord-323404-3mw4q7m3 281 17 double double JJ cord-323404-3mw4q7m3 281 18 - - HYPH cord-323404-3mw4q7m3 281 19 layer layer NN cord-323404-3mw4q7m3 281 20 particle particle NN cord-323404-3mw4q7m3 281 21 ; ; : cord-323404-3mw4q7m3 281 22 IMP IMP NNP cord-323404-3mw4q7m3 281 23 , , , cord-323404-3mw4q7m3 281 24 intramembrane intramembrane NNP cord-323404-3mw4q7m3 281 25 particle particle NN cord-323404-3mw4q7m3 281 26 ; ; : cord-323404-3mw4q7m3 281 27 Ins(1,4,5)P Ins(1,4,5)P NNP cord-323404-3mw4q7m3 281 28 3 3 CD cord-323404-3mw4q7m3 281 29 , , , cord-323404-3mw4q7m3 281 30 inositol inositol NNP cord-323404-3mw4q7m3 281 31 1,4,5-trisphosphate 1,4,5-trisphosphate CD cord-323404-3mw4q7m3 281 32 ; ; : cord-323404-3mw4q7m3 281 33 PLC PLC NNP cord-323404-3mw4q7m3 281 34 , , , cord-323404-3mw4q7m3 281 35 phospholipase phospholipase NN cord-323404-3mw4q7m3 281 36 C c NN cord-323404-3mw4q7m3 281 37 ; ; : cord-323404-3mw4q7m3 281 38 SERCA SERCA NNP cord-323404-3mw4q7m3 281 39 , , , cord-323404-3mw4q7m3 281 40 sarcoplasmic sarcoplasmic NN cord-323404-3mw4q7m3 281 41 / / SYM cord-323404-3mw4q7m3 281 42 endoplasmic endoplasmic NN cord-323404-3mw4q7m3 281 43 - - HYPH cord-323404-3mw4q7m3 281 44 reticulum reticulum NN cord-323404-3mw4q7m3 282 1 Ca ca RB cord-323404-3mw4q7m3 282 2 2 2 CD cord-323404-3mw4q7m3 283 1 + + CC cord-323404-3mw4q7m3 283 2 -ATPase -atpase NN cord-323404-3mw4q7m3 283 3 ; ; : cord-323404-3mw4q7m3 283 4 TLP TLP NNP cord-323404-3mw4q7m3 283 5 , , , cord-323404-3mw4q7m3 283 6 triple triple JJ cord-323404-3mw4q7m3 283 7 - - HYPH cord-323404-3mw4q7m3 283 8 layer layer NN cord-323404-3mw4q7m3 283 9 particle particle NN cord-323404-3mw4q7m3 283 10 . . . cord-323404-3mw4q7m3 284 1 cell cell NN cord-323404-3mw4q7m3 284 2 type type NN cord-323404-3mw4q7m3 284 3 directly directly RB cord-323404-3mw4q7m3 284 4 involved involve VBN cord-323404-3mw4q7m3 284 5 in in IN cord-323404-3mw4q7m3 284 6 the the DT cord-323404-3mw4q7m3 284 7 pathology pathology NN cord-323404-3mw4q7m3 284 8 -rather -rather NN cord-323404-3mw4q7m3 285 1 than than IN cord-323404-3mw4q7m3 285 2 receptor receptor NN cord-323404-3mw4q7m3 285 3 molecules molecule NNS cord-323404-3mw4q7m3 285 4 transfected transfecte VBN cord-323404-3mw4q7m3 285 5 in in IN cord-323404-3mw4q7m3 285 6 standard standard JJ cord-323404-3mw4q7m3 285 7 cell cell NN cord-323404-3mw4q7m3 285 8 - - HYPH cord-323404-3mw4q7m3 285 9 line line NN cord-323404-3mw4q7m3 285 10 models model NNS cord-323404-3mw4q7m3 285 11 -could -could : cord-323404-3mw4q7m3 285 12 help help NN cord-323404-3mw4q7m3 285 13 . . . cord-323404-3mw4q7m3 286 1 It -PRON- PRP cord-323404-3mw4q7m3 286 2 will will MD cord-323404-3mw4q7m3 286 3 also also RB cord-323404-3mw4q7m3 286 4 be be VB cord-323404-3mw4q7m3 286 5 important important JJ cord-323404-3mw4q7m3 286 6 to to TO cord-323404-3mw4q7m3 286 7 define define VB cord-323404-3mw4q7m3 286 8 the the DT cord-323404-3mw4q7m3 286 9 environmental environmental JJ cord-323404-3mw4q7m3 286 10 parameters parameter NNS cord-323404-3mw4q7m3 286 11 that that WDT cord-323404-3mw4q7m3 286 12 influence influence NN cord-323404-3mw4q7m3 286 13 binding binding NN cord-323404-3mw4q7m3 286 14 of of IN cord-323404-3mw4q7m3 286 15 the the DT cord-323404-3mw4q7m3 286 16 virus virus NN cord-323404-3mw4q7m3 286 17 to to IN cord-323404-3mw4q7m3 286 18 its -PRON- PRP$ cord-323404-3mw4q7m3 286 19 receptors receptor NNS cord-323404-3mw4q7m3 286 20 , , , cord-323404-3mw4q7m3 286 21 and and CC cord-323404-3mw4q7m3 286 22 interaction interaction NN cord-323404-3mw4q7m3 286 23 with with IN cord-323404-3mw4q7m3 286 24 co co NNS cord-323404-3mw4q7m3 286 25 - - NNS cord-323404-3mw4q7m3 286 26 receptors receptor NNS cord-323404-3mw4q7m3 286 27 , , , cord-323404-3mw4q7m3 286 28 especially especially RB cord-323404-3mw4q7m3 286 29 when when WRB cord-323404-3mw4q7m3 286 30 considering consider VBG cord-323404-3mw4q7m3 286 31 lectin lectin NN cord-323404-3mw4q7m3 286 32 - - HYPH cord-323404-3mw4q7m3 286 33 sugar sugar NN cord-323404-3mw4q7m3 286 34 interactions interaction NNS cord-323404-3mw4q7m3 286 35 . . . cord-323404-3mw4q7m3 287 1 The the DT cord-323404-3mw4q7m3 287 2 use use NN cord-323404-3mw4q7m3 287 3 of of IN cord-323404-3mw4q7m3 287 4 new new JJ cord-323404-3mw4q7m3 287 5 techniques technique NNS cord-323404-3mw4q7m3 287 6 that that WDT cord-323404-3mw4q7m3 287 7 involve involve VBP cord-323404-3mw4q7m3 287 8 dynamic dynamic JJ cord-323404-3mw4q7m3 287 9 fluorescence fluorescence NN cord-323404-3mw4q7m3 287 10 microscopy microscopy NN cord-323404-3mw4q7m3 287 11 will will MD cord-323404-3mw4q7m3 287 12 help help VB cord-323404-3mw4q7m3 287 13 , , , cord-323404-3mw4q7m3 287 14 both both CC cord-323404-3mw4q7m3 287 15 for for IN cord-323404-3mw4q7m3 287 16 mapping map VBG cord-323404-3mw4q7m3 287 17 the the DT cord-323404-3mw4q7m3 287 18 viral viral JJ cord-323404-3mw4q7m3 287 19 pathway pathway NN cord-323404-3mw4q7m3 287 20 inside inside IN cord-323404-3mw4q7m3 287 21 epithelial epithelial JJ cord-323404-3mw4q7m3 287 22 cells cell NNS cord-323404-3mw4q7m3 287 23 and and CC cord-323404-3mw4q7m3 287 24 also also RB cord-323404-3mw4q7m3 287 25 for for IN cord-323404-3mw4q7m3 287 26 studying study VBG cord-323404-3mw4q7m3 287 27 signalling signal VBG cord-323404-3mw4q7m3 287 28 in in IN cord-323404-3mw4q7m3 287 29 epithelial epithelial JJ cord-323404-3mw4q7m3 287 30 cells cell NNS cord-323404-3mw4q7m3 287 31 . . . cord-323404-3mw4q7m3 288 1 The the DT cord-323404-3mw4q7m3 288 2 first first JJ cord-323404-3mw4q7m3 288 3 step step NN cord-323404-3mw4q7m3 288 4 of of IN cord-323404-3mw4q7m3 288 5 viral viral JJ cord-323404-3mw4q7m3 288 6 attachment attachment NN cord-323404-3mw4q7m3 288 7 to to IN cord-323404-3mw4q7m3 288 8 the the DT cord-323404-3mw4q7m3 288 9 cell cell NN cord-323404-3mw4q7m3 288 10 -through -through : cord-323404-3mw4q7m3 288 11 either either CC cord-323404-3mw4q7m3 288 12 proteoglycan proteoglycan NN cord-323404-3mw4q7m3 288 13 or or CC cord-323404-3mw4q7m3 288 14 glycosphingolipids glycosphingolipid NNS cord-323404-3mw4q7m3 289 1 -raises -raise NNS cord-323404-3mw4q7m3 290 1 the the DT cord-323404-3mw4q7m3 290 2 question question NN cord-323404-3mw4q7m3 290 3 of of IN cord-323404-3mw4q7m3 290 4 the the DT cord-323404-3mw4q7m3 290 5 specific specific JJ cord-323404-3mw4q7m3 290 6 role role NN cord-323404-3mw4q7m3 290 7 of of IN cord-323404-3mw4q7m3 290 8 the the DT cord-323404-3mw4q7m3 290 9 glycosyl glycosyl JJ cord-323404-3mw4q7m3 290 10 epitope epitope NN cord-323404-3mw4q7m3 290 11 , , , cord-323404-3mw4q7m3 290 12 not not RB cord-323404-3mw4q7m3 290 13 only only RB cord-323404-3mw4q7m3 290 14 in in IN cord-323404-3mw4q7m3 290 15 viral viral JJ cord-323404-3mw4q7m3 290 16 attachment attachment NN cord-323404-3mw4q7m3 290 17 , , , cord-323404-3mw4q7m3 290 18 but but CC cord-323404-3mw4q7m3 290 19 also also RB cord-323404-3mw4q7m3 290 20 in in IN cord-323404-3mw4q7m3 290 21 further further JJ cord-323404-3mw4q7m3 290 22 transduction transduction NN cord-323404-3mw4q7m3 290 23 of of IN cord-323404-3mw4q7m3 290 24 signals signal NNS cord-323404-3mw4q7m3 290 25 . . . cord-323404-3mw4q7m3 291 1 The the DT cord-323404-3mw4q7m3 291 2 final final JJ cord-323404-3mw4q7m3 291 3 glycosylation glycosylation NN cord-323404-3mw4q7m3 291 4 state state NN cord-323404-3mw4q7m3 291 5 of of IN cord-323404-3mw4q7m3 291 6 glycoproteins glycoprotein NNS cord-323404-3mw4q7m3 291 7 and and CC cord-323404-3mw4q7m3 291 8 lipids lipid NNS cord-323404-3mw4q7m3 291 9 varies vary VBZ cord-323404-3mw4q7m3 291 10 with with IN cord-323404-3mw4q7m3 291 11 cell cell NN cord-323404-3mw4q7m3 291 12 differentiation differentiation NN cord-323404-3mw4q7m3 291 13 , , , cord-323404-3mw4q7m3 291 14 maturation maturation NN cord-323404-3mw4q7m3 291 15 or or CC cord-323404-3mw4q7m3 291 16 ageing age VBG cord-323404-3mw4q7m3 291 17 54 54 CD cord-323404-3mw4q7m3 291 18 , , , cord-323404-3mw4q7m3 291 19 and and CC cord-323404-3mw4q7m3 291 20 it -PRON- PRP cord-323404-3mw4q7m3 291 21 could could MD cord-323404-3mw4q7m3 291 22 govern govern VB cord-323404-3mw4q7m3 291 23 the the DT cord-323404-3mw4q7m3 291 24 specificity specificity NN cord-323404-3mw4q7m3 291 25 of of IN cord-323404-3mw4q7m3 291 26 the the DT cord-323404-3mw4q7m3 291 27 virus virus NN cord-323404-3mw4q7m3 291 28 - - HYPH cord-323404-3mw4q7m3 291 29 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 291 30 interaction interaction NN cord-323404-3mw4q7m3 291 31 that that WDT cord-323404-3mw4q7m3 291 32 is be VBZ cord-323404-3mw4q7m3 291 33 involved involve VBN cord-323404-3mw4q7m3 291 34 in in IN cord-323404-3mw4q7m3 291 35 viral viral JJ cord-323404-3mw4q7m3 291 36 entry entry NN cord-323404-3mw4q7m3 291 37 into into IN cord-323404-3mw4q7m3 291 38 epithelial epithelial JJ cord-323404-3mw4q7m3 291 39 cells cell NNS cord-323404-3mw4q7m3 291 40 . . . cord-323404-3mw4q7m3 292 1 Lipid lipid NN cord-323404-3mw4q7m3 292 2 microdomains microdomain NNS cord-323404-3mw4q7m3 292 3 participate participate VBP cord-323404-3mw4q7m3 292 4 in in IN cord-323404-3mw4q7m3 292 5 the the DT cord-323404-3mw4q7m3 292 6 clustering clustering NN cord-323404-3mw4q7m3 292 7 of of IN cord-323404-3mw4q7m3 292 8 viral viral JJ cord-323404-3mw4q7m3 292 9 proteins protein NNS cord-323404-3mw4q7m3 292 10 on on IN cord-323404-3mw4q7m3 292 11 the the DT cord-323404-3mw4q7m3 292 12 viral viral JJ cord-323404-3mw4q7m3 292 13 membrane membrane NN cord-323404-3mw4q7m3 292 14 and and CC cord-323404-3mw4q7m3 292 15 cell cell NN cord-323404-3mw4q7m3 292 16 receptors receptor NNS cord-323404-3mw4q7m3 292 17 on on IN cord-323404-3mw4q7m3 292 18 the the DT cord-323404-3mw4q7m3 292 19 cell cell NN cord-323404-3mw4q7m3 292 20 membranes membrane NNS cord-323404-3mw4q7m3 292 21 , , , cord-323404-3mw4q7m3 292 22 which which WDT cord-323404-3mw4q7m3 292 23 favours favour VBZ cord-323404-3mw4q7m3 292 24 virus virus NN cord-323404-3mw4q7m3 292 25 - - HYPH cord-323404-3mw4q7m3 292 26 cell cell NN cord-323404-3mw4q7m3 292 27 interactions interaction NNS cord-323404-3mw4q7m3 292 28 . . . cord-323404-3mw4q7m3 293 1 The the DT cord-323404-3mw4q7m3 293 2 spatio spatio JJ cord-323404-3mw4q7m3 293 3 - - HYPH cord-323404-3mw4q7m3 293 4 temporal temporal JJ cord-323404-3mw4q7m3 293 5 correlation correlation NN cord-323404-3mw4q7m3 293 6 of of IN cord-323404-3mw4q7m3 293 7 the the DT cord-323404-3mw4q7m3 293 8 different different JJ cord-323404-3mw4q7m3 293 9 steps step NNS cord-323404-3mw4q7m3 293 10 of of IN cord-323404-3mw4q7m3 293 11 the the DT cord-323404-3mw4q7m3 293 12 virus virus NN cord-323404-3mw4q7m3 293 13 attachment attachment NN cord-323404-3mw4q7m3 293 14 to to IN cord-323404-3mw4q7m3 293 15 carbohydrates carbohydrate NNS cord-323404-3mw4q7m3 293 16 of of IN cord-323404-3mw4q7m3 293 17 the the DT cord-323404-3mw4q7m3 293 18 cell cell NN cord-323404-3mw4q7m3 293 19 surface surface NN cord-323404-3mw4q7m3 293 20 , , , cord-323404-3mw4q7m3 293 21 and and CC cord-323404-3mw4q7m3 293 22 their -PRON- PRP$ cord-323404-3mw4q7m3 293 23 further further JJ cord-323404-3mw4q7m3 293 24 interaction interaction NN cord-323404-3mw4q7m3 293 25 with with IN cord-323404-3mw4q7m3 293 26 additional additional JJ cord-323404-3mw4q7m3 293 27 protein protein NN cord-323404-3mw4q7m3 293 28 cell cell NN cord-323404-3mw4q7m3 293 29 receptors receptor NNS cord-323404-3mw4q7m3 293 30 or or CC cord-323404-3mw4q7m3 293 31 co co NNS cord-323404-3mw4q7m3 293 32 - - NNS cord-323404-3mw4q7m3 293 33 receptors receptor NNS cord-323404-3mw4q7m3 293 34 , , , cord-323404-3mw4q7m3 293 35 remains remain VBZ cord-323404-3mw4q7m3 293 36 to to TO cord-323404-3mw4q7m3 293 37 be be VB cord-323404-3mw4q7m3 293 38 established establish VBN cord-323404-3mw4q7m3 293 39 . . . cord-323404-3mw4q7m3 294 1 Clearly clearly RB cord-323404-3mw4q7m3 294 2 , , , cord-323404-3mw4q7m3 294 3 epithelia epithelium NNS cord-323404-3mw4q7m3 294 4 are be VBP cord-323404-3mw4q7m3 294 5 more more JJR cord-323404-3mw4q7m3 294 6 than than IN cord-323404-3mw4q7m3 294 7 just just RB cord-323404-3mw4q7m3 294 8 a a DT cord-323404-3mw4q7m3 294 9 physical physical JJ cord-323404-3mw4q7m3 294 10 barrier barrier NN cord-323404-3mw4q7m3 294 11 . . . cord-323404-3mw4q7m3 295 1 They -PRON- PRP cord-323404-3mw4q7m3 295 2 are be VBP cord-323404-3mw4q7m3 295 3 a a DT cord-323404-3mw4q7m3 295 4 dynamic dynamic JJ cord-323404-3mw4q7m3 295 5 host host NN cord-323404-3mw4q7m3 295 6 defence defence NN cord-323404-3mw4q7m3 295 7 system system NN cord-323404-3mw4q7m3 295 8 with with IN cord-323404-3mw4q7m3 295 9 sensor sensor NN cord-323404-3mw4q7m3 295 10 molecules molecule NNS cord-323404-3mw4q7m3 295 11 , , , cord-323404-3mw4q7m3 295 12 signalling signal VBG cord-323404-3mw4q7m3 295 13 circuits circuit NNS cord-323404-3mw4q7m3 295 14 and and CC cord-323404-3mw4q7m3 295 15 effector effector NN cord-323404-3mw4q7m3 295 16 molecules molecule NNS cord-323404-3mw4q7m3 295 17 that that WDT cord-323404-3mw4q7m3 295 18 coordinate coordinate VBP cord-323404-3mw4q7m3 295 19 and and CC cord-323404-3mw4q7m3 295 20 execute execute VB cord-323404-3mw4q7m3 295 21 a a DT cord-323404-3mw4q7m3 295 22 graduated graduate VBN cord-323404-3mw4q7m3 295 23 reaction reaction NN cord-323404-3mw4q7m3 295 24 to to IN cord-323404-3mw4q7m3 295 25 microbes microbe NNS cord-323404-3mw4q7m3 295 26 . . . cord-323404-3mw4q7m3 296 1 We -PRON- PRP cord-323404-3mw4q7m3 296 2 are be VBP cord-323404-3mw4q7m3 296 3 now now RB cord-323404-3mw4q7m3 296 4 on on IN cord-323404-3mw4q7m3 296 5 the the DT cord-323404-3mw4q7m3 296 6 verge verge NN cord-323404-3mw4q7m3 296 7 of of IN cord-323404-3mw4q7m3 296 8 learning learn VBG cord-323404-3mw4q7m3 296 9 more more JJR cord-323404-3mw4q7m3 296 10 about about IN cord-323404-3mw4q7m3 296 11 the the DT cord-323404-3mw4q7m3 296 12 molecules molecule NNS cord-323404-3mw4q7m3 296 13 and and CC cord-323404-3mw4q7m3 296 14 pathways pathway NNS cord-323404-3mw4q7m3 296 15 that that WDT cord-323404-3mw4q7m3 296 16 are be VBP cord-323404-3mw4q7m3 296 17 involved involve VBN cord-323404-3mw4q7m3 296 18 in in IN cord-323404-3mw4q7m3 296 19 these these DT cord-323404-3mw4q7m3 296 20 epithelial epithelial JJ cord-323404-3mw4q7m3 296 21 responses response NNS cord-323404-3mw4q7m3 296 22 . . . cord-323404-3mw4q7m3 297 1 It -PRON- PRP cord-323404-3mw4q7m3 297 2 seems seem VBZ cord-323404-3mw4q7m3 297 3 clear clear JJ cord-323404-3mw4q7m3 297 4 that that IN cord-323404-3mw4q7m3 297 5 no no DT cord-323404-3mw4q7m3 297 6 real real JJ cord-323404-3mw4q7m3 297 7 correlation correlation NN cord-323404-3mw4q7m3 297 8 can can MD cord-323404-3mw4q7m3 297 9 be be VB cord-323404-3mw4q7m3 297 10 made make VBN cord-323404-3mw4q7m3 297 11 between between IN cord-323404-3mw4q7m3 297 12 a a DT cord-323404-3mw4q7m3 297 13 family family NN cord-323404-3mw4q7m3 297 14 ( ( -LRB- cord-323404-3mw4q7m3 297 15 or or CC cord-323404-3mw4q7m3 297 16 even even RB cord-323404-3mw4q7m3 297 17 a a DT cord-323404-3mw4q7m3 297 18 type type NN cord-323404-3mw4q7m3 297 19 ) ) -RRB- cord-323404-3mw4q7m3 297 20 of of IN cord-323404-3mw4q7m3 297 21 virus virus NN cord-323404-3mw4q7m3 297 22 and and CC cord-323404-3mw4q7m3 297 23 a a DT cord-323404-3mw4q7m3 297 24 defined define VBN cord-323404-3mw4q7m3 297 25 mechanism mechanism NN cord-323404-3mw4q7m3 297 26 of of IN cord-323404-3mw4q7m3 297 27 interaction interaction NN cord-323404-3mw4q7m3 297 28 with with IN cord-323404-3mw4q7m3 297 29 the the DT cord-323404-3mw4q7m3 297 30 epithelial epithelial JJ cord-323404-3mw4q7m3 297 31 cell cell NN cord-323404-3mw4q7m3 297 32 . . . cord-323404-3mw4q7m3 298 1 Viruses virus NNS cord-323404-3mw4q7m3 298 2 from from IN cord-323404-3mw4q7m3 298 3 families family NNS cord-323404-3mw4q7m3 298 4 as as RB cord-323404-3mw4q7m3 298 5 different different JJ cord-323404-3mw4q7m3 298 6 as as IN cord-323404-3mw4q7m3 298 7 naked naked JJ cord-323404-3mw4q7m3 298 8 and and CC cord-323404-3mw4q7m3 298 9 enveloped enveloped JJ cord-323404-3mw4q7m3 298 10 viruses virus NNS cord-323404-3mw4q7m3 298 11 can can MD cord-323404-3mw4q7m3 298 12 use use VB cord-323404-3mw4q7m3 298 13 the the DT cord-323404-3mw4q7m3 298 14 same same JJ cord-323404-3mw4q7m3 298 15 attachment attachment NN cord-323404-3mw4q7m3 298 16 receptors receptor NNS cord-323404-3mw4q7m3 298 17 83 83 CD cord-323404-3mw4q7m3 298 18 , , , cord-323404-3mw4q7m3 298 19 87 87 CD cord-323404-3mw4q7m3 298 20 ( ( -LRB- cord-323404-3mw4q7m3 298 21 for for IN cord-323404-3mw4q7m3 298 22 example example NN cord-323404-3mw4q7m3 298 23 , , , cord-323404-3mw4q7m3 298 24 carbohydrates carbohydrate NNS cord-323404-3mw4q7m3 298 25 or or CC cord-323404-3mw4q7m3 298 26 proteins protein NNS cord-323404-3mw4q7m3 298 27 ) ) -RRB- cord-323404-3mw4q7m3 298 28 . . . cord-323404-3mw4q7m3 299 1 Conversely conversely RB cord-323404-3mw4q7m3 299 2 , , , cord-323404-3mw4q7m3 299 3 closely closely RB cord-323404-3mw4q7m3 299 4 related related JJ cord-323404-3mw4q7m3 299 5 viruses virus NNS cord-323404-3mw4q7m3 299 6 from from IN cord-323404-3mw4q7m3 299 7 the the DT cord-323404-3mw4q7m3 299 8 same same JJ cord-323404-3mw4q7m3 299 9 family family NN cord-323404-3mw4q7m3 299 10 might may MD cord-323404-3mw4q7m3 299 11 use use VB cord-323404-3mw4q7m3 299 12 completely completely RB cord-323404-3mw4q7m3 299 13 different different JJ cord-323404-3mw4q7m3 299 14 attachment attachment NN cord-323404-3mw4q7m3 299 15 receptors receptor NNS cord-323404-3mw4q7m3 299 16 that that WDT cord-323404-3mw4q7m3 299 17 will will MD cord-323404-3mw4q7m3 299 18 dictate dictate VB cord-323404-3mw4q7m3 299 19 the the DT cord-323404-3mw4q7m3 299 20 intracellular intracellular JJ cord-323404-3mw4q7m3 299 21 fate fate NN cord-323404-3mw4q7m3 299 22 of of IN cord-323404-3mw4q7m3 299 23 the the DT cord-323404-3mw4q7m3 299 24 virus virus NN cord-323404-3mw4q7m3 299 25 41 41 CD cord-323404-3mw4q7m3 299 26 , , , cord-323404-3mw4q7m3 299 27 81 81 CD cord-323404-3mw4q7m3 299 28 . . . cord-323404-3mw4q7m3 300 1 Even even RB cord-323404-3mw4q7m3 300 2 the the DT cord-323404-3mw4q7m3 300 3 same same JJ cord-323404-3mw4q7m3 300 4 virus virus NN cord-323404-3mw4q7m3 300 5 might may MD cord-323404-3mw4q7m3 300 6 use use VB cord-323404-3mw4q7m3 300 7 the the DT cord-323404-3mw4q7m3 300 8 same same JJ cord-323404-3mw4q7m3 300 9 attachment attachment NN cord-323404-3mw4q7m3 300 10 receptor receptor NN cord-323404-3mw4q7m3 300 11 but but CC cord-323404-3mw4q7m3 300 12 different different JJ cord-323404-3mw4q7m3 300 13 protein protein NN cord-323404-3mw4q7m3 300 14 receptors receptor NNS cord-323404-3mw4q7m3 300 15 depending depend VBG cord-323404-3mw4q7m3 300 16 on on IN cord-323404-3mw4q7m3 300 17 the the DT cord-323404-3mw4q7m3 300 18 type type NN cord-323404-3mw4q7m3 300 19 of of IN cord-323404-3mw4q7m3 300 20 epithelial epithelial JJ cord-323404-3mw4q7m3 300 21 cell cell NN cord-323404-3mw4q7m3 300 22 , , , cord-323404-3mw4q7m3 300 23 which which WDT cord-323404-3mw4q7m3 300 24 extends extend VBZ cord-323404-3mw4q7m3 300 25 its -PRON- PRP$ cord-323404-3mw4q7m3 300 26 infectious infectious JJ cord-323404-3mw4q7m3 300 27 potential potential NN cord-323404-3mw4q7m3 300 28 47 47 CD cord-323404-3mw4q7m3 300 29 . . . cord-323404-3mw4q7m3 301 1 The the DT cord-323404-3mw4q7m3 301 2 cellular cellular JJ cord-323404-3mw4q7m3 301 3 features feature NNS cord-323404-3mw4q7m3 301 4 of of IN cord-323404-3mw4q7m3 301 5 the the DT cord-323404-3mw4q7m3 301 6 epithelial epithelial JJ cord-323404-3mw4q7m3 301 7 target target NN cord-323404-3mw4q7m3 301 8 therefore therefore RB cord-323404-3mw4q7m3 301 9 seem seem VBP cord-323404-3mw4q7m3 301 10 to to TO cord-323404-3mw4q7m3 301 11 be be VB cord-323404-3mw4q7m3 301 12 essential essential JJ cord-323404-3mw4q7m3 301 13 if if IN cord-323404-3mw4q7m3 301 14 we -PRON- PRP cord-323404-3mw4q7m3 301 15 are be VBP cord-323404-3mw4q7m3 301 16 to to TO cord-323404-3mw4q7m3 301 17 describe describe VB cord-323404-3mw4q7m3 301 18 the the DT cord-323404-3mw4q7m3 301 19 mechanisms mechanism NNS cord-323404-3mw4q7m3 301 20 of of IN cord-323404-3mw4q7m3 301 21 a a DT cord-323404-3mw4q7m3 301 22 viral viral JJ cord-323404-3mw4q7m3 301 23 interaction interaction NN cord-323404-3mw4q7m3 301 24 with with IN cord-323404-3mw4q7m3 301 25 an an DT cord-323404-3mw4q7m3 301 26 epithelial epithelial JJ cord-323404-3mw4q7m3 301 27 cell cell NN cord-323404-3mw4q7m3 301 28 . . . cord-323404-3mw4q7m3 302 1 These these DT cord-323404-3mw4q7m3 302 2 features feature NNS cord-323404-3mw4q7m3 302 3 are be VBP cord-323404-3mw4q7m3 302 4 the the DT cord-323404-3mw4q7m3 302 5 epithelial epithelial JJ cord-323404-3mw4q7m3 302 6 trafficking traffic VBG cord-323404-3mw4q7m3 302 7 pathways pathway NNS cord-323404-3mw4q7m3 302 8 and and CC cord-323404-3mw4q7m3 302 9 the the DT cord-323404-3mw4q7m3 302 10 epithelial epithelial NN cord-323404-3mw4q7m3 302 11 - - HYPH cord-323404-3mw4q7m3 302 12 specific specific JJ cord-323404-3mw4q7m3 302 13 protein protein NN cord-323404-3mw4q7m3 302 14 and and CC cord-323404-3mw4q7m3 302 15 lipid lipid NN cord-323404-3mw4q7m3 302 16 composition composition NN cord-323404-3mw4q7m3 302 17 that that WDT cord-323404-3mw4q7m3 302 18 are be VBP cord-323404-3mw4q7m3 302 19 associated associate VBN cord-323404-3mw4q7m3 302 20 with with IN cord-323404-3mw4q7m3 302 21 their -PRON- PRP$ cord-323404-3mw4q7m3 302 22 signalling signal VBG cord-323404-3mw4q7m3 302 23 pathways pathway NNS cord-323404-3mw4q7m3 302 24 . . . cord-323404-3mw4q7m3 303 1 This this DT cord-323404-3mw4q7m3 303 2 description description NN cord-323404-3mw4q7m3 303 3 emphasizes emphasize VBZ cord-323404-3mw4q7m3 303 4 how how WRB cord-323404-3mw4q7m3 303 5 viruses virus NNS cord-323404-3mw4q7m3 303 6 act act VBP cord-323404-3mw4q7m3 303 7 as as IN cord-323404-3mw4q7m3 303 8 pathogens pathogen NNS cord-323404-3mw4q7m3 303 9 -that -that WDT cord-323404-3mw4q7m3 303 10 is be VBZ cord-323404-3mw4q7m3 303 11 , , , cord-323404-3mw4q7m3 303 12 by by IN cord-323404-3mw4q7m3 303 13 subverting subvert VBG cord-323404-3mw4q7m3 303 14 the the DT cord-323404-3mw4q7m3 303 15 normal normal JJ cord-323404-3mw4q7m3 303 16 epithelial epithelial JJ cord-323404-3mw4q7m3 303 17 cell cell NN cord-323404-3mw4q7m3 303 18 function function NN cord-323404-3mw4q7m3 303 19 to to IN cord-323404-3mw4q7m3 303 20 their -PRON- PRP$ cord-323404-3mw4q7m3 303 21 own own JJ cord-323404-3mw4q7m3 303 22 benefit benefit NN cord-323404-3mw4q7m3 303 23 . . . cord-323404-3mw4q7m3 304 1 We -PRON- PRP cord-323404-3mw4q7m3 304 2 are be VBP cord-323404-3mw4q7m3 304 3 just just RB cord-323404-3mw4q7m3 304 4 beginning begin VBG cord-323404-3mw4q7m3 304 5 to to TO cord-323404-3mw4q7m3 304 6 understand understand VB cord-323404-3mw4q7m3 304 7 the the DT cord-323404-3mw4q7m3 304 8 molecular molecular JJ cord-323404-3mw4q7m3 304 9 interactions interaction NNS cord-323404-3mw4q7m3 304 10 between between IN cord-323404-3mw4q7m3 304 11 viral viral JJ cord-323404-3mw4q7m3 304 12 and and CC cord-323404-3mw4q7m3 304 13 cellular cellular JJ cord-323404-3mw4q7m3 304 14 components component NNS cord-323404-3mw4q7m3 304 15 . . . cord-323404-3mw4q7m3 305 1 However however RB cord-323404-3mw4q7m3 305 2 , , , cord-323404-3mw4q7m3 305 3 the the DT cord-323404-3mw4q7m3 305 4 factors factor NNS cord-323404-3mw4q7m3 305 5 that that WDT cord-323404-3mw4q7m3 305 6 control control VBP cord-323404-3mw4q7m3 305 7 the the DT cord-323404-3mw4q7m3 305 8 finely finely RB cord-323404-3mw4q7m3 305 9 regulated regulate VBN cord-323404-3mw4q7m3 305 10 specificity specificity NN cord-323404-3mw4q7m3 305 11 that that WDT cord-323404-3mw4q7m3 305 12 is be VBZ cord-323404-3mw4q7m3 305 13 observed observe VBN cord-323404-3mw4q7m3 305 14 in in IN cord-323404-3mw4q7m3 305 15 vivo vivo NN cord-323404-3mw4q7m3 305 16 for for IN cord-323404-3mw4q7m3 305 17 each each DT cord-323404-3mw4q7m3 305 18 virus virus NN cord-323404-3mw4q7m3 305 19 , , , cord-323404-3mw4q7m3 305 20 for for IN cord-323404-3mw4q7m3 305 21 a a DT cord-323404-3mw4q7m3 305 22 defined define VBN cord-323404-3mw4q7m3 305 23 target target NN cord-323404-3mw4q7m3 305 24 cell cell NN cord-323404-3mw4q7m3 305 25 , , , cord-323404-3mw4q7m3 305 26 remain remain VBP cord-323404-3mw4q7m3 305 27 unclear unclear JJ cord-323404-3mw4q7m3 305 28 . . . cord-323404-3mw4q7m3 306 1 The the DT cord-323404-3mw4q7m3 306 2 signalling signalling NN cord-323404-3mw4q7m3 306 3 that that WDT cord-323404-3mw4q7m3 306 4 is be VBZ cord-323404-3mw4q7m3 306 5 induced induce VBN cord-323404-3mw4q7m3 306 6 when when WRB cord-323404-3mw4q7m3 306 7 a a DT cord-323404-3mw4q7m3 306 8 virus virus NN cord-323404-3mw4q7m3 306 9 binds bind VBZ cord-323404-3mw4q7m3 306 10 its -PRON- PRP$ cord-323404-3mw4q7m3 306 11 receptors receptor NNS cord-323404-3mw4q7m3 306 12 should should MD cord-323404-3mw4q7m3 306 13 be be VB cord-323404-3mw4q7m3 306 14 compared compare VBN cord-323404-3mw4q7m3 306 15 with with IN cord-323404-3mw4q7m3 306 16 the the DT cord-323404-3mw4q7m3 306 17 pathways pathway NNS cord-323404-3mw4q7m3 306 18 that that WDT cord-323404-3mw4q7m3 306 19 are be VBP cord-323404-3mw4q7m3 306 20 activated activate VBN cord-323404-3mw4q7m3 306 21 when when WRB cord-323404-3mw4q7m3 306 22 the the DT cord-323404-3mw4q7m3 306 23 natural natural JJ cord-323404-3mw4q7m3 306 24 ligands ligand NNS cord-323404-3mw4q7m3 306 25 bind bind VBP cord-323404-3mw4q7m3 306 26 these these DT cord-323404-3mw4q7m3 306 27 same same JJ cord-323404-3mw4q7m3 306 28 receptors receptor NNS cord-323404-3mw4q7m3 306 29 . . . cord-323404-3mw4q7m3 307 1 Entry entry NN cord-323404-3mw4q7m3 307 2 receptors receptor NNS cord-323404-3mw4q7m3 307 3 for for IN cord-323404-3mw4q7m3 307 4 many many JJ cord-323404-3mw4q7m3 307 5 viruses virus NNS cord-323404-3mw4q7m3 307 6 have have VBP cord-323404-3mw4q7m3 307 7 now now RB cord-323404-3mw4q7m3 307 8 been be VBN cord-323404-3mw4q7m3 307 9 described describe VBN cord-323404-3mw4q7m3 307 10 , , , cord-323404-3mw4q7m3 307 11 and and CC cord-323404-3mw4q7m3 307 12 it -PRON- PRP cord-323404-3mw4q7m3 307 13 will will MD cord-323404-3mw4q7m3 307 14 be be VB cord-323404-3mw4q7m3 307 15 important important JJ cord-323404-3mw4q7m3 307 16 to to TO cord-323404-3mw4q7m3 307 17 correlate correlate VB cord-323404-3mw4q7m3 307 18 data datum NNS cord-323404-3mw4q7m3 307 19 from from IN cord-323404-3mw4q7m3 307 20 both both DT cord-323404-3mw4q7m3 307 21 cell cell NN cord-323404-3mw4q7m3 307 22 lines line NNS cord-323404-3mw4q7m3 307 23 and and CC cord-323404-3mw4q7m3 307 24 PRIMARY primary JJ cord-323404-3mw4q7m3 307 25 CELLS cell NNS cord-323404-3mw4q7m3 307 26 , , , cord-323404-3mw4q7m3 307 27 despite despite IN cord-323404-3mw4q7m3 307 28 the the DT cord-323404-3mw4q7m3 307 29 pitfalls pitfall NNS cord-323404-3mw4q7m3 307 30 inherent inherent JJ cord-323404-3mw4q7m3 307 31 in in IN cord-323404-3mw4q7m3 307 32 each each DT cord-323404-3mw4q7m3 307 33 system system NN cord-323404-3mw4q7m3 307 34 ( ( -LRB- cord-323404-3mw4q7m3 307 35 BOX BOX NNP cord-323404-3mw4q7m3 307 36 3 3 CD cord-323404-3mw4q7m3 307 37 ) ) -RRB- cord-323404-3mw4q7m3 307 38 . . . cord-323404-3mw4q7m3 308 1 In in IN cord-323404-3mw4q7m3 308 2 this this DT cord-323404-3mw4q7m3 308 3 regard regard NN cord-323404-3mw4q7m3 308 4 , , , cord-323404-3mw4q7m3 308 5 studies study NNS cord-323404-3mw4q7m3 308 6 that that WDT cord-323404-3mw4q7m3 308 7 use use VBP cord-323404-3mw4q7m3 308 8 the the DT cord-323404-3mw4q7m3 308 9 PRIMARY primary JJ cord-323404-3mw4q7m3 308 10 CELL cell NN cord-323404-3mw4q7m3 308 11 A a DT cord-323404-3mw4q7m3 308 12 cell cell NN cord-323404-3mw4q7m3 308 13 that that WDT cord-323404-3mw4q7m3 308 14 is be VBZ cord-323404-3mw4q7m3 308 15 isolated isolate VBN cord-323404-3mw4q7m3 308 16 directly directly RB cord-323404-3mw4q7m3 308 17 from from IN cord-323404-3mw4q7m3 308 18 living live VBG cord-323404-3mw4q7m3 308 19 tissues tissue NNS cord-323404-3mw4q7m3 308 20 instead instead RB cord-323404-3mw4q7m3 308 21 of of IN cord-323404-3mw4q7m3 308 22 transformed transform VBN cord-323404-3mw4q7m3 308 23 cells cell NNS cord-323404-3mw4q7m3 308 24 . . . cord-323404-3mw4q7m3 309 1 The the DT cord-323404-3mw4q7m3 309 2 sugar sugar NN cord-323404-3mw4q7m3 309 3 code code NN cord-323404-3mw4q7m3 309 4 : : : cord-323404-3mw4q7m3 309 5 functional functional JJ cord-323404-3mw4q7m3 309 6 lectinomics lectinomic NNS cord-323404-3mw4q7m3 309 7 Virus Virus NNP cord-323404-3mw4q7m3 309 8 entry entry NN cord-323404-3mw4q7m3 309 9 and and CC cord-323404-3mw4q7m3 309 10 release release NN cord-323404-3mw4q7m3 309 11 in in IN cord-323404-3mw4q7m3 309 12 polarized polarized JJ cord-323404-3mw4q7m3 309 13 epithelial epithelial JJ cord-323404-3mw4q7m3 309 14 cells cell NNS cord-323404-3mw4q7m3 309 15 Transcytosis Transcytosis NNP cord-323404-3mw4q7m3 309 16 of of IN cord-323404-3mw4q7m3 309 17 infectious infectious JJ cord-323404-3mw4q7m3 309 18 human human JJ cord-323404-3mw4q7m3 309 19 immunodeficiency immunodeficiency NN cord-323404-3mw4q7m3 309 20 virus virus NN cord-323404-3mw4q7m3 309 21 across across IN cord-323404-3mw4q7m3 309 22 a a DT cord-323404-3mw4q7m3 309 23 tight tight JJ cord-323404-3mw4q7m3 309 24 human human JJ cord-323404-3mw4q7m3 309 25 epithelial epithelial JJ cord-323404-3mw4q7m3 309 26 cell cell NN cord-323404-3mw4q7m3 309 27 line line NN cord-323404-3mw4q7m3 309 28 barrier barrier NN cord-323404-3mw4q7m3 310 1 Primary primary JJ cord-323404-3mw4q7m3 310 2 intestinal intestinal JJ cord-323404-3mw4q7m3 310 3 epithelial epithelial JJ cord-323404-3mw4q7m3 310 4 cells cell NNS cord-323404-3mw4q7m3 310 5 selectively selectively RB cord-323404-3mw4q7m3 310 6 transfer transfer VBP cord-323404-3mw4q7m3 310 7 R5 R5 NNP cord-323404-3mw4q7m3 310 8 HIV-1 HIV-1 NNP cord-323404-3mw4q7m3 310 9 to to IN cord-323404-3mw4q7m3 310 10 CCR5 CCR5 NNP cord-323404-3mw4q7m3 310 11 + + CC cord-323404-3mw4q7m3 310 12 cells cell NNS cord-323404-3mw4q7m3 311 1 An an DT cord-323404-3mw4q7m3 311 2 ex ex NN cord-323404-3mw4q7m3 311 3 vivo vivo NN cord-323404-3mw4q7m3 311 4 system system NN cord-323404-3mw4q7m3 311 5 using use VBG cord-323404-3mw4q7m3 311 6 human human JJ cord-323404-3mw4q7m3 311 7 primary primary JJ cord-323404-3mw4q7m3 311 8 epithelial epithelial JJ cord-323404-3mw4q7m3 311 9 cells cell NNS cord-323404-3mw4q7m3 311 10 to to TO cord-323404-3mw4q7m3 311 11 show show VB cord-323404-3mw4q7m3 311 12 the the DT cord-323404-3mw4q7m3 311 13 selective selective JJ cord-323404-3mw4q7m3 311 14 filter filter NN cord-323404-3mw4q7m3 311 15 function function NN cord-323404-3mw4q7m3 311 16 of of IN cord-323404-3mw4q7m3 311 17 an an DT cord-323404-3mw4q7m3 311 18 epithelial epithelial JJ cord-323404-3mw4q7m3 311 19 barrier barrier NN cord-323404-3mw4q7m3 311 20 during during IN cord-323404-3mw4q7m3 311 21 a a DT cord-323404-3mw4q7m3 311 22 viral viral JJ cord-323404-3mw4q7m3 311 23 infection infection NN cord-323404-3mw4q7m3 311 24 Break break VB cord-323404-3mw4q7m3 311 25 ins in NNS cord-323404-3mw4q7m3 311 26 and and CC cord-323404-3mw4q7m3 311 27 break break VB cord-323404-3mw4q7m3 311 28 outs out NNS cord-323404-3mw4q7m3 311 29 : : : cord-323404-3mw4q7m3 311 30 viral viral JJ cord-323404-3mw4q7m3 311 31 interactions interaction NNS cord-323404-3mw4q7m3 311 32 with with IN cord-323404-3mw4q7m3 311 33 the the DT cord-323404-3mw4q7m3 311 34 cytoskeleton cytoskeleton NN cord-323404-3mw4q7m3 311 35 of of IN cord-323404-3mw4q7m3 311 36 mammalian mammalian JJ cord-323404-3mw4q7m3 311 37 cells cell NNS cord-323404-3mw4q7m3 311 38 Epithelial epithelial JJ cord-323404-3mw4q7m3 311 39 cell cell NN cord-323404-3mw4q7m3 311 40 polarization polarization NN cord-323404-3mw4q7m3 311 41 is be VBZ cord-323404-3mw4q7m3 311 42 a a DT cord-323404-3mw4q7m3 311 43 determinant determinant NN cord-323404-3mw4q7m3 311 44 in in IN cord-323404-3mw4q7m3 311 45 the the DT cord-323404-3mw4q7m3 311 46 infectious infectious JJ cord-323404-3mw4q7m3 311 47 outcome outcome NN cord-323404-3mw4q7m3 311 48 of of IN cord-323404-3mw4q7m3 311 49 immunoglobulin immunoglobulin NN cord-323404-3mw4q7m3 311 50 A a NN cord-323404-3mw4q7m3 311 51 - - HYPH cord-323404-3mw4q7m3 311 52 mediated mediate VBN cord-323404-3mw4q7m3 311 53 entry entry NN cord-323404-3mw4q7m3 311 54 by by IN cord-323404-3mw4q7m3 311 55 Epstein Epstein NNP cord-323404-3mw4q7m3 311 56 - - HYPH cord-323404-3mw4q7m3 311 57 Barr Barr NNP cord-323404-3mw4q7m3 311 58 virus virus NN cord-323404-3mw4q7m3 311 59 Epstein Epstein NNP cord-323404-3mw4q7m3 311 60 - - HYPH cord-323404-3mw4q7m3 311 61 Barr Barr NNP cord-323404-3mw4q7m3 311 62 virus virus NN cord-323404-3mw4q7m3 311 63 - - : cord-323404-3mw4q7m3 311 64 encoded encode VBN cord-323404-3mw4q7m3 311 65 LMP1 LMP1 NNP cord-323404-3mw4q7m3 311 66 and and CC cord-323404-3mw4q7m3 311 67 CD40 CD40 NNP cord-323404-3mw4q7m3 312 1 mediate mediate VB cord-323404-3mw4q7m3 312 2 IL-6 IL-6 NNP cord-323404-3mw4q7m3 312 3 production production NN cord-323404-3mw4q7m3 312 4 in in IN cord-323404-3mw4q7m3 312 5 epithelial epithelial JJ cord-323404-3mw4q7m3 312 6 cells cell NNS cord-323404-3mw4q7m3 312 7 via via IN cord-323404-3mw4q7m3 312 8 an an DT cord-323404-3mw4q7m3 312 9 NF nf NN cord-323404-3mw4q7m3 312 10 - - HYPH cord-323404-3mw4q7m3 312 11 κB κB NNP cord-323404-3mw4q7m3 312 12 pathway pathway NN cord-323404-3mw4q7m3 312 13 involving involve VBG cord-323404-3mw4q7m3 313 1 TNF TNF NNP cord-323404-3mw4q7m3 313 2 receptor receptor NN cord-323404-3mw4q7m3 313 3 - - HYPH cord-323404-3mw4q7m3 313 4 associated associate VBN cord-323404-3mw4q7m3 313 5 factors factor NNS cord-323404-3mw4q7m3 313 6 Detection Detection NNP cord-323404-3mw4q7m3 313 7 of of IN cord-323404-3mw4q7m3 313 8 Epstein Epstein NNP cord-323404-3mw4q7m3 313 9 - - HYPH cord-323404-3mw4q7m3 313 10 Barr Barr NNP cord-323404-3mw4q7m3 313 11 viral viral JJ cord-323404-3mw4q7m3 313 12 DNA dna NN cord-323404-3mw4q7m3 313 13 internal internal JJ cord-323404-3mw4q7m3 313 14 repeats repeat NNS cord-323404-3mw4q7m3 313 15 in in IN cord-323404-3mw4q7m3 313 16 the the DT cord-323404-3mw4q7m3 313 17 nasopharyngeal nasopharyngeal JJ cord-323404-3mw4q7m3 313 18 mucosa mucosa NN cord-323404-3mw4q7m3 313 19 of of IN cord-323404-3mw4q7m3 313 20 Chinese Chinese NNP cord-323404-3mw4q7m3 313 21 with with IN cord-323404-3mw4q7m3 313 22 IgA IgA NNP cord-323404-3mw4q7m3 313 23 / / SYM cord-323404-3mw4q7m3 313 24 EBV EBV NNP cord-323404-3mw4q7m3 313 25 - - HYPH cord-323404-3mw4q7m3 313 26 specific specific JJ cord-323404-3mw4q7m3 313 27 antibodies antibody NNS cord-323404-3mw4q7m3 313 28 Immunofluorescence Immunofluorescence NNP cord-323404-3mw4q7m3 313 29 analysis analysis NN cord-323404-3mw4q7m3 313 30 of of IN cord-323404-3mw4q7m3 313 31 poliovirus poliovirus NN cord-323404-3mw4q7m3 313 32 receptor receptor NN cord-323404-3mw4q7m3 313 33 expression expression NN cord-323404-3mw4q7m3 313 34 in in IN cord-323404-3mw4q7m3 313 35 Peyer Peyer NNP cord-323404-3mw4q7m3 313 36 's 's POS cord-323404-3mw4q7m3 313 37 patches patch NNS cord-323404-3mw4q7m3 313 38 of of IN cord-323404-3mw4q7m3 313 39 humans human NNS cord-323404-3mw4q7m3 313 40 , , , cord-323404-3mw4q7m3 313 41 primates primate NNS cord-323404-3mw4q7m3 313 42 , , , cord-323404-3mw4q7m3 313 43 and and CC cord-323404-3mw4q7m3 313 44 CD155 cd155 NN cord-323404-3mw4q7m3 313 45 transgenic transgenic JJ cord-323404-3mw4q7m3 313 46 mice mouse NNS cord-323404-3mw4q7m3 313 47 : : : cord-323404-3mw4q7m3 314 1 implications implication NNS cord-323404-3mw4q7m3 314 2 for for IN cord-323404-3mw4q7m3 314 3 poliovirus poliovirus NN cord-323404-3mw4q7m3 314 4 infection infection NN cord-323404-3mw4q7m3 314 5 Transepithelial transepithelial JJ cord-323404-3mw4q7m3 314 6 transport transport NN cord-323404-3mw4q7m3 314 7 of of IN cord-323404-3mw4q7m3 314 8 HIV-1 HIV-1 NNP cord-323404-3mw4q7m3 314 9 by by IN cord-323404-3mw4q7m3 314 10 M M NNP cord-323404-3mw4q7m3 314 11 cells cell NNS cord-323404-3mw4q7m3 314 12 is be VBZ cord-323404-3mw4q7m3 314 13 receptor receptor NN cord-323404-3mw4q7m3 314 14 - - HYPH cord-323404-3mw4q7m3 314 15 mediated mediate VBN cord-323404-3mw4q7m3 314 16 Intestinal Intestinal NNP cord-323404-3mw4q7m3 314 17 M M NNP cord-323404-3mw4q7m3 314 18 cells cell NNS cord-323404-3mw4q7m3 314 19 : : : cord-323404-3mw4q7m3 314 20 a a DT cord-323404-3mw4q7m3 314 21 pathway pathway NN cord-323404-3mw4q7m3 314 22 for for IN cord-323404-3mw4q7m3 314 23 entry entry NN cord-323404-3mw4q7m3 314 24 of of IN cord-323404-3mw4q7m3 314 25 reovirus reovirus NNP cord-323404-3mw4q7m3 314 26 into into IN cord-323404-3mw4q7m3 314 27 the the DT cord-323404-3mw4q7m3 314 28 host host NN cord-323404-3mw4q7m3 314 29 Human human JJ cord-323404-3mw4q7m3 314 30 coronavirus coronavirus NN cord-323404-3mw4q7m3 314 31 229E 229e CD cord-323404-3mw4q7m3 315 1 infects infect VBZ cord-323404-3mw4q7m3 315 2 polarized polarized JJ cord-323404-3mw4q7m3 315 3 airway airway NN cord-323404-3mw4q7m3 315 4 epithelia epithelium NNS cord-323404-3mw4q7m3 315 5 from from IN cord-323404-3mw4q7m3 315 6 the the DT cord-323404-3mw4q7m3 315 7 apical apical JJ cord-323404-3mw4q7m3 315 8 surface surface NN cord-323404-3mw4q7m3 315 9 Entry entry NN cord-323404-3mw4q7m3 315 10 and and CC cord-323404-3mw4q7m3 315 11 release release NN cord-323404-3mw4q7m3 315 12 of of IN cord-323404-3mw4q7m3 315 13 measles measle NNS cord-323404-3mw4q7m3 315 14 virus virus NN cord-323404-3mw4q7m3 315 15 are be VBP cord-323404-3mw4q7m3 315 16 polarized polarize VBN cord-323404-3mw4q7m3 315 17 in in IN cord-323404-3mw4q7m3 315 18 epithelial epithelial JJ cord-323404-3mw4q7m3 315 19 cells cell NNS cord-323404-3mw4q7m3 315 20 Polarized polarize VBN cord-323404-3mw4q7m3 315 21 entry entry NN cord-323404-3mw4q7m3 315 22 and and CC cord-323404-3mw4q7m3 315 23 release release NN cord-323404-3mw4q7m3 315 24 in in IN cord-323404-3mw4q7m3 315 25 epithelial epithelial JJ cord-323404-3mw4q7m3 315 26 cells cell NNS cord-323404-3mw4q7m3 315 27 of of IN cord-323404-3mw4q7m3 315 28 Black Black NNP cord-323404-3mw4q7m3 315 29 Creek Creek NNP cord-323404-3mw4q7m3 315 30 Canal Canal NNP cord-323404-3mw4q7m3 315 31 virus virus NN cord-323404-3mw4q7m3 315 32 , , , cord-323404-3mw4q7m3 315 33 a a DT cord-323404-3mw4q7m3 315 34 New New NNP cord-323404-3mw4q7m3 315 35 World World NNP cord-323404-3mw4q7m3 315 36 hantavirus hantavirus NN cord-323404-3mw4q7m3 315 37 Human human JJ cord-323404-3mw4q7m3 315 38 cytomegalovirus cytomegalovirus JJ cord-323404-3mw4q7m3 315 39 infection infection NN cord-323404-3mw4q7m3 315 40 of of IN cord-323404-3mw4q7m3 315 41 caco-2 caco-2 NNP cord-323404-3mw4q7m3 315 42 cells cell NNS cord-323404-3mw4q7m3 315 43 occurs occur VBZ cord-323404-3mw4q7m3 315 44 at at IN cord-323404-3mw4q7m3 315 45 the the DT cord-323404-3mw4q7m3 315 46 basolateral basolateral JJ cord-323404-3mw4q7m3 315 47 membrane membrane NN cord-323404-3mw4q7m3 315 48 and and CC cord-323404-3mw4q7m3 315 49 is be VBZ cord-323404-3mw4q7m3 315 50 differentiation differentiation NN cord-323404-3mw4q7m3 315 51 state state NN cord-323404-3mw4q7m3 315 52 dependent dependent JJ cord-323404-3mw4q7m3 315 53 A a DT cord-323404-3mw4q7m3 315 54 first first JJ cord-323404-3mw4q7m3 315 55 step step NN cord-323404-3mw4q7m3 315 56 toward toward IN cord-323404-3mw4q7m3 315 57 understanding understand VBG cord-323404-3mw4q7m3 315 58 membrane membrane NN cord-323404-3mw4q7m3 315 59 fusion fusion NN cord-323404-3mw4q7m3 315 60 induced induce VBN cord-323404-3mw4q7m3 315 61 by by IN cord-323404-3mw4q7m3 315 62 herpes herpes NNP cord-323404-3mw4q7m3 315 63 simplex simplex NNP cord-323404-3mw4q7m3 315 64 virus virus NN cord-323404-3mw4q7m3 315 65 Disruption Disruption NNP cord-323404-3mw4q7m3 315 66 of of IN cord-323404-3mw4q7m3 315 67 adherens adheren NNS cord-323404-3mw4q7m3 315 68 junctions junction NNS cord-323404-3mw4q7m3 315 69 liberates liberate VBZ cord-323404-3mw4q7m3 315 70 nectin-1 nectin-1 NNP cord-323404-3mw4q7m3 315 71 to to TO cord-323404-3mw4q7m3 315 72 serve serve VB cord-323404-3mw4q7m3 315 73 as as IN cord-323404-3mw4q7m3 315 74 receptor receptor NN cord-323404-3mw4q7m3 315 75 for for IN cord-323404-3mw4q7m3 315 76 herpes herpes NNP cord-323404-3mw4q7m3 315 77 simplex simplex NNP cord-323404-3mw4q7m3 315 78 virus virus NN cord-323404-3mw4q7m3 315 79 and and CC cord-323404-3mw4q7m3 315 80 pseudorabies pseudorabies NN cord-323404-3mw4q7m3 315 81 virus virus NN cord-323404-3mw4q7m3 315 82 entry entry NN cord-323404-3mw4q7m3 315 83 Entry Entry NNP cord-323404-3mw4q7m3 315 84 of of IN cord-323404-3mw4q7m3 315 85 poliovirus poliovirus NN cord-323404-3mw4q7m3 315 86 into into IN cord-323404-3mw4q7m3 315 87 cells cell NNS cord-323404-3mw4q7m3 315 88 is be VBZ cord-323404-3mw4q7m3 315 89 blocked block VBN cord-323404-3mw4q7m3 315 90 by by IN cord-323404-3mw4q7m3 315 91 valinomycin valinomycin NNS cord-323404-3mw4q7m3 315 92 and and CC cord-323404-3mw4q7m3 315 93 concanamycin concanamycin NNS cord-323404-3mw4q7m3 315 94 A a DT cord-323404-3mw4q7m3 315 95 Uptake Uptake NNP cord-323404-3mw4q7m3 315 96 of of IN cord-323404-3mw4q7m3 315 97 poliovirus poliovirus NN cord-323404-3mw4q7m3 315 98 into into IN cord-323404-3mw4q7m3 315 99 the the DT cord-323404-3mw4q7m3 315 100 endosomal endosomal NNP cord-323404-3mw4q7m3 315 101 system system NN cord-323404-3mw4q7m3 315 102 of of IN cord-323404-3mw4q7m3 315 103 HeLa HeLa NNP cord-323404-3mw4q7m3 315 104 cells cell NNS cord-323404-3mw4q7m3 315 105 Interactions interaction NNS cord-323404-3mw4q7m3 315 106 between between IN cord-323404-3mw4q7m3 315 107 rotavirus rotavirus NN cord-323404-3mw4q7m3 315 108 and and CC cord-323404-3mw4q7m3 315 109 gastrointestinal gastrointestinal JJ cord-323404-3mw4q7m3 315 110 cells cell NNS cord-323404-3mw4q7m3 316 1 Influenza Influenza NNP cord-323404-3mw4q7m3 316 2 A a DT cord-323404-3mw4q7m3 316 3 viruses virus NNS cord-323404-3mw4q7m3 316 4 lacking lack VBG cord-323404-3mw4q7m3 316 5 sialidase sialidase NN cord-323404-3mw4q7m3 316 6 activity activity NN cord-323404-3mw4q7m3 316 7 can can MD cord-323404-3mw4q7m3 316 8 undergo undergo VB cord-323404-3mw4q7m3 316 9 multiple multiple JJ cord-323404-3mw4q7m3 316 10 cycles cycle NNS cord-323404-3mw4q7m3 316 11 of of IN cord-323404-3mw4q7m3 316 12 replication replication NN cord-323404-3mw4q7m3 316 13 in in IN cord-323404-3mw4q7m3 316 14 cell cell NN cord-323404-3mw4q7m3 316 15 culture culture NN cord-323404-3mw4q7m3 316 16 , , , cord-323404-3mw4q7m3 316 17 eggs egg NNS cord-323404-3mw4q7m3 316 18 , , , cord-323404-3mw4q7m3 316 19 or or CC cord-323404-3mw4q7m3 316 20 mice mouse NNS cord-323404-3mw4q7m3 316 21 Infection infection NN cord-323404-3mw4q7m3 316 22 of of IN cord-323404-3mw4q7m3 316 23 polarized polarized JJ cord-323404-3mw4q7m3 316 24 cultures culture NNS cord-323404-3mw4q7m3 316 25 of of IN cord-323404-3mw4q7m3 316 26 human human JJ cord-323404-3mw4q7m3 316 27 intestinal intestinal JJ cord-323404-3mw4q7m3 316 28 epithelial epithelial JJ cord-323404-3mw4q7m3 316 29 cells cell NNS cord-323404-3mw4q7m3 316 30 with with IN cord-323404-3mw4q7m3 316 31 hepatitis hepatitis NN cord-323404-3mw4q7m3 316 32 A A NNP cord-323404-3mw4q7m3 316 33 virus virus NN cord-323404-3mw4q7m3 316 34 : : : cord-323404-3mw4q7m3 316 35 vectorial vectorial JJ cord-323404-3mw4q7m3 316 36 release release NN cord-323404-3mw4q7m3 316 37 of of IN cord-323404-3mw4q7m3 316 38 progeny progeny JJ cord-323404-3mw4q7m3 316 39 virions virion NNS cord-323404-3mw4q7m3 316 40 through through IN cord-323404-3mw4q7m3 316 41 apical apical JJ cord-323404-3mw4q7m3 316 42 cellular cellular JJ cord-323404-3mw4q7m3 316 43 membranes membrane NNS cord-323404-3mw4q7m3 316 44 Herpes Herpes NNP cord-323404-3mw4q7m3 316 45 simplex simplex NN cord-323404-3mw4q7m3 316 46 virus virus NN cord-323404-3mw4q7m3 316 47 glycoprotein glycoprotein NN cord-323404-3mw4q7m3 316 48 D d NN cord-323404-3mw4q7m3 316 49 bound bind VBN cord-323404-3mw4q7m3 316 50 to to IN cord-323404-3mw4q7m3 316 51 the the DT cord-323404-3mw4q7m3 316 52 human human JJ cord-323404-3mw4q7m3 316 53 receptor receptor NN cord-323404-3mw4q7m3 316 54 HveA HveA NNP cord-323404-3mw4q7m3 316 55 Centripetal Centripetal NNP cord-323404-3mw4q7m3 316 56 transport transport NN cord-323404-3mw4q7m3 316 57 of of IN cord-323404-3mw4q7m3 316 58 herpes herpes NN cord-323404-3mw4q7m3 316 59 simplex simplex NNP cord-323404-3mw4q7m3 316 60 virus virus NN cord-323404-3mw4q7m3 316 61 in in IN cord-323404-3mw4q7m3 316 62 human human JJ cord-323404-3mw4q7m3 316 63 retinal retinal JJ cord-323404-3mw4q7m3 316 64 pigment pigment NN cord-323404-3mw4q7m3 316 65 epithelial epithelial JJ cord-323404-3mw4q7m3 316 66 cells cell NNS cord-323404-3mw4q7m3 316 67 in in IN cord-323404-3mw4q7m3 316 68 vitro vitro FW cord-323404-3mw4q7m3 316 69 Entry entry NN cord-323404-3mw4q7m3 316 70 of of IN cord-323404-3mw4q7m3 316 71 human human JJ cord-323404-3mw4q7m3 316 72 cytomegalovirus cytomegalovirus NN cord-323404-3mw4q7m3 316 73 into into IN cord-323404-3mw4q7m3 316 74 retinal retinal JJ cord-323404-3mw4q7m3 316 75 pigment pigment NN cord-323404-3mw4q7m3 316 76 epithelial epithelial NN cord-323404-3mw4q7m3 316 77 and and CC cord-323404-3mw4q7m3 316 78 endothelial endothelial JJ cord-323404-3mw4q7m3 316 79 cells cell NNS cord-323404-3mw4q7m3 316 80 by by IN cord-323404-3mw4q7m3 316 81 endocytosis endocytosis NN cord-323404-3mw4q7m3 316 82 Role role NN cord-323404-3mw4q7m3 316 83 of of IN cord-323404-3mw4q7m3 316 84 apical apical JJ cord-323404-3mw4q7m3 316 85 and and CC cord-323404-3mw4q7m3 316 86 basolateral basolateral JJ cord-323404-3mw4q7m3 316 87 membranes membrane NNS cord-323404-3mw4q7m3 316 88 in in IN cord-323404-3mw4q7m3 316 89 replication replication NN cord-323404-3mw4q7m3 316 90 of of IN cord-323404-3mw4q7m3 316 91 human human JJ cord-323404-3mw4q7m3 316 92 cytomegalovirus cytomegalovirus NN cord-323404-3mw4q7m3 316 93 in in IN cord-323404-3mw4q7m3 316 94 polarized polarized JJ cord-323404-3mw4q7m3 316 95 retinal retinal JJ cord-323404-3mw4q7m3 316 96 pigment pigment NN cord-323404-3mw4q7m3 316 97 epithelial epithelial NN cord-323404-3mw4q7m3 316 98 cells cell NNS cord-323404-3mw4q7m3 316 99 Herpes Herpes NNP cord-323404-3mw4q7m3 316 100 virus virus NN cord-323404-3mw4q7m3 316 101 infection infection NN cord-323404-3mw4q7m3 316 102 of of IN cord-323404-3mw4q7m3 316 103 RPE rpe NN cord-323404-3mw4q7m3 316 104 and and CC cord-323404-3mw4q7m3 316 105 MDCK MDCK NNP cord-323404-3mw4q7m3 316 106 cells cell NNS cord-323404-3mw4q7m3 316 107 : : : cord-323404-3mw4q7m3 317 1 polarity polarity NN cord-323404-3mw4q7m3 317 2 of of IN cord-323404-3mw4q7m3 317 3 infection infection NN cord-323404-3mw4q7m3 317 4 Polarity Polarity NNP cord-323404-3mw4q7m3 317 5 influences influence VBZ cord-323404-3mw4q7m3 317 6 the the DT cord-323404-3mw4q7m3 317 7 efficiency efficiency NN cord-323404-3mw4q7m3 317 8 of of IN cord-323404-3mw4q7m3 317 9 recombinant recombinant JJ cord-323404-3mw4q7m3 317 10 adenoassociated adenoassociate VBN cord-323404-3mw4q7m3 317 11 virus virus NN cord-323404-3mw4q7m3 317 12 infection infection NN cord-323404-3mw4q7m3 317 13 in in IN cord-323404-3mw4q7m3 317 14 differentiated differentiated JJ cord-323404-3mw4q7m3 317 15 airway airway NN cord-323404-3mw4q7m3 317 16 epithelia epithelium NNS cord-323404-3mw4q7m3 318 1 The the DT cord-323404-3mw4q7m3 318 2 ubiquitin ubiquitin NN cord-323404-3mw4q7m3 318 3 - - HYPH cord-323404-3mw4q7m3 318 4 proteasome proteasome VBN cord-323404-3mw4q7m3 318 5 system system NN cord-323404-3mw4q7m3 318 6 and and CC cord-323404-3mw4q7m3 319 1 endocytosis endocytosis NN cord-323404-3mw4q7m3 319 2 Endosomal Endosomal NNP cord-323404-3mw4q7m3 319 3 processing processing NN cord-323404-3mw4q7m3 319 4 limits limit NNS cord-323404-3mw4q7m3 319 5 gene gene NN cord-323404-3mw4q7m3 319 6 transfer transfer NN cord-323404-3mw4q7m3 319 7 to to IN cord-323404-3mw4q7m3 319 8 polarized polarized JJ cord-323404-3mw4q7m3 319 9 airway airway NN cord-323404-3mw4q7m3 319 10 epithelia epithelium NNS cord-323404-3mw4q7m3 319 11 by by IN cord-323404-3mw4q7m3 319 12 adeno adeno NN cord-323404-3mw4q7m3 319 13 - - HYPH cord-323404-3mw4q7m3 319 14 associated associate VBN cord-323404-3mw4q7m3 319 15 virus virus NN cord-323404-3mw4q7m3 319 16 Lipid Lipid NNP cord-323404-3mw4q7m3 319 17 raft raft NN cord-323404-3mw4q7m3 319 18 microdomains microdomain NNS cord-323404-3mw4q7m3 319 19 : : : cord-323404-3mw4q7m3 320 1 a a DT cord-323404-3mw4q7m3 320 2 gateway gateway NN cord-323404-3mw4q7m3 320 3 for for IN cord-323404-3mw4q7m3 320 4 compartmentalized compartmentalized JJ cord-323404-3mw4q7m3 320 5 trafficking trafficking NN cord-323404-3mw4q7m3 320 6 of of IN cord-323404-3mw4q7m3 320 7 Ebola Ebola NNP cord-323404-3mw4q7m3 320 8 and and CC cord-323404-3mw4q7m3 320 9 Marburg Marburg NNP cord-323404-3mw4q7m3 320 10 viruses virus NNS cord-323404-3mw4q7m3 320 11 Measles Measles NNP cord-323404-3mw4q7m3 320 12 virus virus NN cord-323404-3mw4q7m3 320 13 structural structural JJ cord-323404-3mw4q7m3 320 14 components component NNS cord-323404-3mw4q7m3 320 15 are be VBP cord-323404-3mw4q7m3 320 16 enriched enrich VBN cord-323404-3mw4q7m3 320 17 into into IN cord-323404-3mw4q7m3 320 18 lipid lipid NN cord-323404-3mw4q7m3 320 19 raft raft NN cord-323404-3mw4q7m3 320 20 microdomains microdomain NNS cord-323404-3mw4q7m3 320 21 : : : cord-323404-3mw4q7m3 320 22 a a DT cord-323404-3mw4q7m3 320 23 potential potential JJ cord-323404-3mw4q7m3 320 24 cellular cellular JJ cord-323404-3mw4q7m3 320 25 location location NN cord-323404-3mw4q7m3 320 26 for for IN cord-323404-3mw4q7m3 320 27 virus virus NN cord-323404-3mw4q7m3 320 28 assembly assembly NN cord-323404-3mw4q7m3 320 29 Lipid Lipid NNP cord-323404-3mw4q7m3 320 30 rafts raft NNS cord-323404-3mw4q7m3 320 31 and and CC cord-323404-3mw4q7m3 320 32 signal signal NN cord-323404-3mw4q7m3 320 33 transduction transduction NN cord-323404-3mw4q7m3 321 1 Caveolar Caveolar NNP cord-323404-3mw4q7m3 321 2 endocytosis endocytosis NN cord-323404-3mw4q7m3 321 3 of of IN cord-323404-3mw4q7m3 321 4 simian simian JJ cord-323404-3mw4q7m3 321 5 virus virus NN cord-323404-3mw4q7m3 321 6 40 40 CD cord-323404-3mw4q7m3 321 7 is be VBZ cord-323404-3mw4q7m3 321 8 followed follow VBN cord-323404-3mw4q7m3 321 9 by by IN cord-323404-3mw4q7m3 321 10 Brefeldin Brefeldin NNP cord-323404-3mw4q7m3 321 11 A A NNP cord-323404-3mw4q7m3 321 12 - - HYPH cord-323404-3mw4q7m3 321 13 sensitive sensitive JJ cord-323404-3mw4q7m3 321 14 transport transport NN cord-323404-3mw4q7m3 321 15 to to IN cord-323404-3mw4q7m3 321 16 the the DT cord-323404-3mw4q7m3 321 17 endoplasmic endoplasmic NN cord-323404-3mw4q7m3 321 18 reticulum reticulum NN cord-323404-3mw4q7m3 321 19 , , , cord-323404-3mw4q7m3 321 20 where where WRB cord-323404-3mw4q7m3 321 21 the the DT cord-323404-3mw4q7m3 321 22 virus virus NN cord-323404-3mw4q7m3 321 23 disassembles disassemble VBZ cord-323404-3mw4q7m3 321 24 Major major JJ cord-323404-3mw4q7m3 321 25 histocompatibility histocompatibility NN cord-323404-3mw4q7m3 321 26 complex complex NN cord-323404-3mw4q7m3 321 27 class class NN cord-323404-3mw4q7m3 322 1 I -PRON- PRP cord-323404-3mw4q7m3 322 2 molecules molecule NNS cord-323404-3mw4q7m3 322 3 mediate mediate VBP cord-323404-3mw4q7m3 322 4 association association NN cord-323404-3mw4q7m3 322 5 of of IN cord-323404-3mw4q7m3 322 6 SV40 SV40 NNP cord-323404-3mw4q7m3 322 7 with with IN cord-323404-3mw4q7m3 322 8 caveolae caveolae NNP cord-323404-3mw4q7m3 322 9 JC JC NNP cord-323404-3mw4q7m3 322 10 virus virus NN cord-323404-3mw4q7m3 322 11 enters enter VBZ cord-323404-3mw4q7m3 322 12 human human JJ cord-323404-3mw4q7m3 322 13 glial glial JJ cord-323404-3mw4q7m3 322 14 cells cell NNS cord-323404-3mw4q7m3 322 15 by by IN cord-323404-3mw4q7m3 322 16 clathrin clathrin NN cord-323404-3mw4q7m3 322 17 - - HYPH cord-323404-3mw4q7m3 322 18 dependent dependent JJ cord-323404-3mw4q7m3 322 19 receptor receptor NN cord-323404-3mw4q7m3 322 20 - - HYPH cord-323404-3mw4q7m3 322 21 mediated mediate VBN cord-323404-3mw4q7m3 322 22 endocytosis endocytosis NN cord-323404-3mw4q7m3 322 23 Canine canine JJ cord-323404-3mw4q7m3 322 24 and and CC cord-323404-3mw4q7m3 322 25 feline feline JJ cord-323404-3mw4q7m3 322 26 parvoviruses parvovirus NNS cord-323404-3mw4q7m3 322 27 can can MD cord-323404-3mw4q7m3 322 28 use use VB cord-323404-3mw4q7m3 322 29 human human JJ cord-323404-3mw4q7m3 322 30 or or CC cord-323404-3mw4q7m3 322 31 feline feline JJ cord-323404-3mw4q7m3 322 32 transferrin transferrin NN cord-323404-3mw4q7m3 322 33 receptors receptor NNS cord-323404-3mw4q7m3 322 34 to to TO cord-323404-3mw4q7m3 322 35 bind bind VB cord-323404-3mw4q7m3 322 36 , , , cord-323404-3mw4q7m3 322 37 enter enter VB cord-323404-3mw4q7m3 322 38 , , , cord-323404-3mw4q7m3 322 39 and and CC cord-323404-3mw4q7m3 322 40 infect infect VB cord-323404-3mw4q7m3 322 41 cells cell NNS cord-323404-3mw4q7m3 322 42 Entry Entry NNP cord-323404-3mw4q7m3 322 43 of of IN cord-323404-3mw4q7m3 322 44 human human JJ cord-323404-3mw4q7m3 322 45 parechovirus parechovirus NNP cord-323404-3mw4q7m3 322 46 1 1 CD cord-323404-3mw4q7m3 323 1 The the DT cord-323404-3mw4q7m3 323 2 clathrin clathrin NN cord-323404-3mw4q7m3 323 3 endocytic endocytic JJ cord-323404-3mw4q7m3 323 4 pathway pathway NN cord-323404-3mw4q7m3 323 5 in in IN cord-323404-3mw4q7m3 323 6 viral viral JJ cord-323404-3mw4q7m3 323 7 infection infection NN cord-323404-3mw4q7m3 324 1 The the DT cord-323404-3mw4q7m3 324 2 structure structure NN cord-323404-3mw4q7m3 324 3 and and CC cord-323404-3mw4q7m3 324 4 function function NN cord-323404-3mw4q7m3 324 5 of of IN cord-323404-3mw4q7m3 324 6 a a DT cord-323404-3mw4q7m3 324 7 foot foot NN cord-323404-3mw4q7m3 324 8 - - HYPH cord-323404-3mw4q7m3 324 9 andmouth andmouth NNP cord-323404-3mw4q7m3 324 10 disease disease NN cord-323404-3mw4q7m3 324 11 virus virus NN cord-323404-3mw4q7m3 324 12 - - HYPH cord-323404-3mw4q7m3 324 13 oligosaccharide oligosaccharide NN cord-323404-3mw4q7m3 324 14 receptor receptor NN cord-323404-3mw4q7m3 324 15 complex complex NN cord-323404-3mw4q7m3 325 1 This this DT cord-323404-3mw4q7m3 325 2 work work NN cord-323404-3mw4q7m3 325 3 tracks track VBZ cord-323404-3mw4q7m3 325 4 the the DT cord-323404-3mw4q7m3 325 5 entry entry NN cord-323404-3mw4q7m3 325 6 of of IN cord-323404-3mw4q7m3 325 7 comparatively comparatively RB cord-323404-3mw4q7m3 325 8 different different JJ cord-323404-3mw4q7m3 325 9 viruses virus NNS cord-323404-3mw4q7m3 325 10 of of IN cord-323404-3mw4q7m3 325 11 the the DT cord-323404-3mw4q7m3 325 12 same same JJ cord-323404-3mw4q7m3 325 13 family family NN cord-323404-3mw4q7m3 325 14 into into IN cord-323404-3mw4q7m3 325 15 cells cell NNS cord-323404-3mw4q7m3 325 16 by by IN cord-323404-3mw4q7m3 325 17 cellfractionation cellfractionation NN cord-323404-3mw4q7m3 325 18 analysis analysis NN cord-323404-3mw4q7m3 326 1 A a DT cord-323404-3mw4q7m3 326 2 clear clear JJ cord-323404-3mw4q7m3 326 3 review review NN cord-323404-3mw4q7m3 326 4 on on IN cord-323404-3mw4q7m3 326 5 the the DT cord-323404-3mw4q7m3 326 6 role role NN cord-323404-3mw4q7m3 326 7 of of IN cord-323404-3mw4q7m3 326 8 calcium calcium NN cord-323404-3mw4q7m3 326 9 in in IN cord-323404-3mw4q7m3 326 10 viral viral JJ cord-323404-3mw4q7m3 326 11 infection infection NN cord-323404-3mw4q7m3 326 12 of of IN cord-323404-3mw4q7m3 326 13 the the DT cord-323404-3mw4q7m3 326 14 epithelial epithelial JJ cord-323404-3mw4q7m3 326 15 cell cell NN cord-323404-3mw4q7m3 326 16 , , , cord-323404-3mw4q7m3 326 17 and and CC cord-323404-3mw4q7m3 326 18 the the DT cord-323404-3mw4q7m3 326 19 viral viral JJ cord-323404-3mw4q7m3 326 20 soluble soluble JJ cord-323404-3mw4q7m3 326 21 virulence virulence NN cord-323404-3mw4q7m3 326 22 factors factor NNS cord-323404-3mw4q7m3 326 23 Pathogenic pathogenic JJ cord-323404-3mw4q7m3 326 24 trickery trickery NN cord-323404-3mw4q7m3 326 25 : : : cord-323404-3mw4q7m3 326 26 deception deception NN cord-323404-3mw4q7m3 326 27 of of IN cord-323404-3mw4q7m3 326 28 host host NN cord-323404-3mw4q7m3 326 29 cell cell NN cord-323404-3mw4q7m3 326 30 processes process NNS cord-323404-3mw4q7m3 326 31 Structural structural JJ cord-323404-3mw4q7m3 326 32 basis basis NN cord-323404-3mw4q7m3 326 33 of of IN cord-323404-3mw4q7m3 326 34 lectin lectin NN cord-323404-3mw4q7m3 326 35 - - HYPH cord-323404-3mw4q7m3 326 36 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 326 37 recognition recognition NN cord-323404-3mw4q7m3 327 1 An an DT cord-323404-3mw4q7m3 327 2 important important JJ cord-323404-3mw4q7m3 327 3 review review NN cord-323404-3mw4q7m3 327 4 on on IN cord-323404-3mw4q7m3 327 5 the the DT cord-323404-3mw4q7m3 327 6 characteristics characteristic NNS cord-323404-3mw4q7m3 327 7 of of IN cord-323404-3mw4q7m3 327 8 lectin lectin NN cord-323404-3mw4q7m3 327 9 - - HYPH cord-323404-3mw4q7m3 327 10 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 327 11 interactions interaction NNS cord-323404-3mw4q7m3 327 12 that that WDT cord-323404-3mw4q7m3 327 13 rely rely VBP cord-323404-3mw4q7m3 327 14 on on IN cord-323404-3mw4q7m3 327 15 the the DT cord-323404-3mw4q7m3 327 16 structure structure NN cord-323404-3mw4q7m3 327 17 and and CC cord-323404-3mw4q7m3 327 18 oligomerization oligomerization NN cord-323404-3mw4q7m3 327 19 state state NN cord-323404-3mw4q7m3 327 20 of of IN cord-323404-3mw4q7m3 327 21 the the DT cord-323404-3mw4q7m3 327 22 lectin lectin NN cord-323404-3mw4q7m3 327 23 peptide peptide NN cord-323404-3mw4q7m3 327 24 , , , cord-323404-3mw4q7m3 327 25 as as RB cord-323404-3mw4q7m3 327 26 well well RB cord-323404-3mw4q7m3 327 27 as as IN cord-323404-3mw4q7m3 327 28 on on IN cord-323404-3mw4q7m3 327 29 the the DT cord-323404-3mw4q7m3 327 30 nature nature NN cord-323404-3mw4q7m3 327 31 and and CC cord-323404-3mw4q7m3 327 32 conformation conformation NN cord-323404-3mw4q7m3 327 33 of of IN cord-323404-3mw4q7m3 327 34 the the DT cord-323404-3mw4q7m3 327 35 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 327 36 A a DT cord-323404-3mw4q7m3 327 37 novel novel JJ cord-323404-3mw4q7m3 327 38 cell cell NN cord-323404-3mw4q7m3 327 39 entry entry NN cord-323404-3mw4q7m3 327 40 pathway pathway NN cord-323404-3mw4q7m3 327 41 for for IN cord-323404-3mw4q7m3 327 42 a a DT cord-323404-3mw4q7m3 327 43 DAF DAF NNP cord-323404-3mw4q7m3 327 44 - - HYPH cord-323404-3mw4q7m3 327 45 using use VBG cord-323404-3mw4q7m3 327 46 human human JJ cord-323404-3mw4q7m3 327 47 enterovirus enterovirus NN cord-323404-3mw4q7m3 327 48 is be VBZ cord-323404-3mw4q7m3 327 49 dependent dependent JJ cord-323404-3mw4q7m3 327 50 on on IN cord-323404-3mw4q7m3 327 51 lipid lipid NN cord-323404-3mw4q7m3 327 52 rafts raft NNS cord-323404-3mw4q7m3 327 53 Cell cell NN cord-323404-3mw4q7m3 327 54 biology biology NN cord-323404-3mw4q7m3 327 55 of of IN cord-323404-3mw4q7m3 327 56 virus virus NN cord-323404-3mw4q7m3 327 57 entry entry NN cord-323404-3mw4q7m3 327 58 Herpesviruses Herpesviruses NNP cord-323404-3mw4q7m3 327 59 and and CC cord-323404-3mw4q7m3 327 60 heparansulfate heparansulfate NNP cord-323404-3mw4q7m3 327 61 : : : cord-323404-3mw4q7m3 327 62 an an DT cord-323404-3mw4q7m3 327 63 intimate intimate JJ cord-323404-3mw4q7m3 327 64 relationship relationship NN cord-323404-3mw4q7m3 327 65 in in IN cord-323404-3mw4q7m3 327 66 aid aid NN cord-323404-3mw4q7m3 327 67 of of IN cord-323404-3mw4q7m3 327 68 viral viral JJ cord-323404-3mw4q7m3 327 69 entry entry NN cord-323404-3mw4q7m3 327 70 Reference reference NN cord-323404-3mw4q7m3 327 71 47 47 CD cord-323404-3mw4q7m3 327 72 uses use VBZ cord-323404-3mw4q7m3 327 73 herpesviruses herpesviruse NNS cord-323404-3mw4q7m3 327 74 to to TO cord-323404-3mw4q7m3 327 75 emphasize emphasize VB cord-323404-3mw4q7m3 327 76 the the DT cord-323404-3mw4q7m3 327 77 role role NN cord-323404-3mw4q7m3 327 78 of of IN cord-323404-3mw4q7m3 327 79 heparan heparan JJ cord-323404-3mw4q7m3 327 80 sulphate sulphate NN cord-323404-3mw4q7m3 327 81 -a -a : cord-323404-3mw4q7m3 327 82 ubiquitous ubiquitous JJ cord-323404-3mw4q7m3 327 83 component component NN cord-323404-3mw4q7m3 327 84 of of IN cord-323404-3mw4q7m3 327 85 cell cell NN cord-323404-3mw4q7m3 327 86 proteoglycans proteoglycan NNS cord-323404-3mw4q7m3 327 87 -in -in : cord-323404-3mw4q7m3 327 88 viral viral JJ cord-323404-3mw4q7m3 327 89 entry entry NN cord-323404-3mw4q7m3 327 90 into into IN cord-323404-3mw4q7m3 327 91 host host NN cord-323404-3mw4q7m3 327 92 cells cell NNS cord-323404-3mw4q7m3 327 93 Receptor receptor NN cord-323404-3mw4q7m3 327 94 binding binding NN cord-323404-3mw4q7m3 327 95 and and CC cord-323404-3mw4q7m3 327 96 membrane membrane NN cord-323404-3mw4q7m3 327 97 fusion fusion NN cord-323404-3mw4q7m3 327 98 in in IN cord-323404-3mw4q7m3 327 99 virus virus NN cord-323404-3mw4q7m3 327 100 entry entry NN cord-323404-3mw4q7m3 327 101 : : : cord-323404-3mw4q7m3 327 102 the the DT cord-323404-3mw4q7m3 327 103 influenza influenza NN cord-323404-3mw4q7m3 327 104 hemagglutinin hemagglutinin VBN cord-323404-3mw4q7m3 327 105 Broad broad JJ cord-323404-3mw4q7m3 327 106 distribution distribution NN cord-323404-3mw4q7m3 327 107 of of IN cord-323404-3mw4q7m3 327 108 the the DT cord-323404-3mw4q7m3 327 109 JC JC NNP cord-323404-3mw4q7m3 327 110 virus virus NN cord-323404-3mw4q7m3 327 111 receptor receptor NN cord-323404-3mw4q7m3 327 112 contrasts contrast VBZ cord-323404-3mw4q7m3 327 113 with with IN cord-323404-3mw4q7m3 327 114 a a DT cord-323404-3mw4q7m3 327 115 marked marked JJ cord-323404-3mw4q7m3 327 116 cellular cellular JJ cord-323404-3mw4q7m3 327 117 restriction restriction NN cord-323404-3mw4q7m3 327 118 of of IN cord-323404-3mw4q7m3 327 119 virus virus NN cord-323404-3mw4q7m3 327 120 replication replication NN cord-323404-3mw4q7m3 327 121 Sendai Sendai NNP cord-323404-3mw4q7m3 327 122 virus virus NN cord-323404-3mw4q7m3 327 123 utilizes utilize VBZ cord-323404-3mw4q7m3 327 124 specific specific JJ cord-323404-3mw4q7m3 327 125 sialyloligosaccharides sialyloligosaccharide NNS cord-323404-3mw4q7m3 327 126 as as IN cord-323404-3mw4q7m3 327 127 host host NN cord-323404-3mw4q7m3 327 128 cell cell NN cord-323404-3mw4q7m3 327 129 receptor receptor NN cord-323404-3mw4q7m3 327 130 determinants determinant NNS cord-323404-3mw4q7m3 327 131 Glycosphingolipid Glycosphingolipid NNP cord-323404-3mw4q7m3 327 132 binding bind VBG cord-323404-3mw4q7m3 327 133 specificities specificity NNS cord-323404-3mw4q7m3 327 134 of of IN cord-323404-3mw4q7m3 327 135 rotavirus rotavirus NN cord-323404-3mw4q7m3 327 136 : : : cord-323404-3mw4q7m3 327 137 identification identification NN cord-323404-3mw4q7m3 327 138 of of IN cord-323404-3mw4q7m3 327 139 a a DT cord-323404-3mw4q7m3 327 140 sialic sialic JJ cord-323404-3mw4q7m3 327 141 acid acid NN cord-323404-3mw4q7m3 327 142 - - HYPH cord-323404-3mw4q7m3 327 143 binding bind VBG cord-323404-3mw4q7m3 327 144 epitope epitope NN cord-323404-3mw4q7m3 327 145 Among among IN cord-323404-3mw4q7m3 327 146 the the DT cord-323404-3mw4q7m3 327 147 various various JJ cord-323404-3mw4q7m3 327 148 ganglioside ganglioside NN cord-323404-3mw4q7m3 327 149 specificities specificity NNS cord-323404-3mw4q7m3 327 150 for for IN cord-323404-3mw4q7m3 327 151 different different JJ cord-323404-3mw4q7m3 327 152 rotavirus rotavirus NN cord-323404-3mw4q7m3 327 153 strains strain NNS cord-323404-3mw4q7m3 328 1 , , , cord-323404-3mw4q7m3 328 2 a a DT cord-323404-3mw4q7m3 328 3 common common JJ cord-323404-3mw4q7m3 328 4 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 328 5 minimal minimal JJ cord-323404-3mw4q7m3 328 6 structural structural JJ cord-323404-3mw4q7m3 328 7 element element NN cord-323404-3mw4q7m3 328 8 is be VBZ cord-323404-3mw4q7m3 328 9 shown show VBN cord-323404-3mw4q7m3 328 10 to to TO cord-323404-3mw4q7m3 328 11 be be VB cord-323404-3mw4q7m3 328 12 required require VBN cord-323404-3mw4q7m3 328 13 for for IN cord-323404-3mw4q7m3 328 14 binding bind VBG cord-323404-3mw4q7m3 328 15 of of IN cord-323404-3mw4q7m3 328 16 these these DT cord-323404-3mw4q7m3 328 17 strains strain NNS cord-323404-3mw4q7m3 328 18 Using use VBG cord-323404-3mw4q7m3 328 19 naked naked JJ cord-323404-3mw4q7m3 328 20 reovirus reoviru NNS cord-323404-3mw4q7m3 328 21 as as IN cord-323404-3mw4q7m3 328 22 an an DT cord-323404-3mw4q7m3 328 23 example example NN cord-323404-3mw4q7m3 328 24 , , , cord-323404-3mw4q7m3 328 25 this this DT cord-323404-3mw4q7m3 328 26 paper paper NN cord-323404-3mw4q7m3 328 27 shows show VBZ cord-323404-3mw4q7m3 328 28 the the DT cord-323404-3mw4q7m3 328 29 cooperativity cooperativity NN cord-323404-3mw4q7m3 328 30 of of IN cord-323404-3mw4q7m3 328 31 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 328 32 attachment attachment NN cord-323404-3mw4q7m3 328 33 and and CC cord-323404-3mw4q7m3 328 34 protein protein NN cord-323404-3mw4q7m3 328 35 receptors receptor NNS cord-323404-3mw4q7m3 328 36 for for IN cord-323404-3mw4q7m3 328 37 virus virus NN cord-323404-3mw4q7m3 328 38 interaction interaction NN cord-323404-3mw4q7m3 328 39 with with IN cord-323404-3mw4q7m3 328 40 epithelial epithelial JJ cord-323404-3mw4q7m3 328 41 cells cell NNS cord-323404-3mw4q7m3 328 42 Sorting sort VBG cord-323404-3mw4q7m3 328 43 of of IN cord-323404-3mw4q7m3 328 44 newly newly RB cord-323404-3mw4q7m3 328 45 synthesized synthesize VBN cord-323404-3mw4q7m3 328 46 glycosphingolipids glycosphingolipid NNS cord-323404-3mw4q7m3 328 47 to to IN cord-323404-3mw4q7m3 328 48 the the DT cord-323404-3mw4q7m3 328 49 two two CD cord-323404-3mw4q7m3 328 50 surface surface NN cord-323404-3mw4q7m3 328 51 domains domain NNS cord-323404-3mw4q7m3 328 52 of of IN cord-323404-3mw4q7m3 328 53 epithelial epithelial JJ cord-323404-3mw4q7m3 328 54 cells cell NNS cord-323404-3mw4q7m3 329 1 The the DT cord-323404-3mw4q7m3 329 2 cell cell NN cord-323404-3mw4q7m3 329 3 - - HYPH cord-323404-3mw4q7m3 329 4 to to IN cord-323404-3mw4q7m3 329 5 - - HYPH cord-323404-3mw4q7m3 329 6 cell cell NN cord-323404-3mw4q7m3 329 7 transfer transfer NN cord-323404-3mw4q7m3 329 8 of of IN cord-323404-3mw4q7m3 329 9 information information NN cord-323404-3mw4q7m3 329 10 through through IN cord-323404-3mw4q7m3 329 11 the the DT cord-323404-3mw4q7m3 329 12 synapse synapse NN cord-323404-3mw4q7m3 329 13 , , , cord-323404-3mw4q7m3 329 14 which which WDT cord-323404-3mw4q7m3 329 15 is be VBZ cord-323404-3mw4q7m3 329 16 characteristic characteristic JJ cord-323404-3mw4q7m3 329 17 of of IN cord-323404-3mw4q7m3 329 18 neural neural JJ cord-323404-3mw4q7m3 329 19 cells cell NNS cord-323404-3mw4q7m3 329 20 , , , cord-323404-3mw4q7m3 329 21 has have VBZ cord-323404-3mw4q7m3 329 22 recently recently RB cord-323404-3mw4q7m3 329 23 been be VBN cord-323404-3mw4q7m3 329 24 extended extend VBN cord-323404-3mw4q7m3 329 25 to to IN cord-323404-3mw4q7m3 329 26 other other JJ cord-323404-3mw4q7m3 329 27 cell cell NN cord-323404-3mw4q7m3 329 28 types type NNS cord-323404-3mw4q7m3 329 29 such such JJ cord-323404-3mw4q7m3 329 30 as as IN cord-323404-3mw4q7m3 329 31 immunological immunological JJ cord-323404-3mw4q7m3 329 32 synapses synapsis NNS cord-323404-3mw4q7m3 329 33 . . . cord-323404-3mw4q7m3 330 1 The the DT cord-323404-3mw4q7m3 330 2 importance importance NN cord-323404-3mw4q7m3 330 3 of of IN cord-323404-3mw4q7m3 330 4 carbohydrates carbohydrate NNS cord-323404-3mw4q7m3 330 5 in in IN cord-323404-3mw4q7m3 330 6 such such JJ cord-323404-3mw4q7m3 330 7 cellular cellular JJ cord-323404-3mw4q7m3 330 8 functions function NNS cord-323404-3mw4q7m3 330 9 is be VBZ cord-323404-3mw4q7m3 330 10 underlined underline VBN cord-323404-3mw4q7m3 330 11 Human human JJ cord-323404-3mw4q7m3 330 12 immunodeficiency immunodeficiency NN cord-323404-3mw4q7m3 330 13 virus virus NN cord-323404-3mw4q7m3 330 14 and and CC cord-323404-3mw4q7m3 330 15 host host NN cord-323404-3mw4q7m3 330 16 cell cell NN cord-323404-3mw4q7m3 330 17 lipids lipid NNS cord-323404-3mw4q7m3 330 18 . . . cord-323404-3mw4q7m3 331 1 Interesting interesting JJ cord-323404-3mw4q7m3 331 2 pathways pathway NNS cord-323404-3mw4q7m3 331 3 in in IN cord-323404-3mw4q7m3 331 4 research research NN cord-323404-3mw4q7m3 331 5 for for IN cord-323404-3mw4q7m3 331 6 a a DT cord-323404-3mw4q7m3 331 7 new new JJ cord-323404-3mw4q7m3 331 8 HIV HIV NNP cord-323404-3mw4q7m3 331 9 therapy therapy NN cord-323404-3mw4q7m3 331 10 Secretory Secretory NNP cord-323404-3mw4q7m3 331 11 IgA IgA NNP cord-323404-3mw4q7m3 331 12 specific specific JJ cord-323404-3mw4q7m3 331 13 for for IN cord-323404-3mw4q7m3 331 14 a a DT cord-323404-3mw4q7m3 331 15 conserved conserved JJ cord-323404-3mw4q7m3 331 16 epitope epitope NN cord-323404-3mw4q7m3 331 17 on on IN cord-323404-3mw4q7m3 331 18 gp41 gp41 NNP cord-323404-3mw4q7m3 331 19 envelope envelope NN cord-323404-3mw4q7m3 331 20 glycoprotein glycoprotein NN cord-323404-3mw4q7m3 331 21 inhibits inhibit VBZ cord-323404-3mw4q7m3 331 22 epithelial epithelial JJ cord-323404-3mw4q7m3 331 23 transcytosis transcytosis NN cord-323404-3mw4q7m3 331 24 of of IN cord-323404-3mw4q7m3 331 25 HIV-1 HIV-1 NNP cord-323404-3mw4q7m3 331 26 HIV-1 HIV-1 NNP cord-323404-3mw4q7m3 331 27 gp41 gp41 NNP cord-323404-3mw4q7m3 331 28 envelope envelope NN cord-323404-3mw4q7m3 331 29 residues residue NNS cord-323404-3mw4q7m3 332 1 650 650 CD cord-323404-3mw4q7m3 332 2 - - SYM cord-323404-3mw4q7m3 332 3 685 685 CD cord-323404-3mw4q7m3 332 4 exposed expose VBN cord-323404-3mw4q7m3 332 5 on on IN cord-323404-3mw4q7m3 332 6 native native JJ cord-323404-3mw4q7m3 332 7 virus virus NN cord-323404-3mw4q7m3 332 8 act act NN cord-323404-3mw4q7m3 332 9 as as IN cord-323404-3mw4q7m3 332 10 a a DT cord-323404-3mw4q7m3 332 11 lectin lectin NN cord-323404-3mw4q7m3 332 12 to to TO cord-323404-3mw4q7m3 332 13 bind bind VB cord-323404-3mw4q7m3 332 14 epithelial epithelial JJ cord-323404-3mw4q7m3 332 15 cell cell NN cord-323404-3mw4q7m3 332 16 galactosyl galactosyl NN cord-323404-3mw4q7m3 332 17 ceramide ceramide NN cord-323404-3mw4q7m3 332 18 Synthetic synthetic JJ cord-323404-3mw4q7m3 332 19 soluble soluble JJ cord-323404-3mw4q7m3 332 20 analogs analog NNS cord-323404-3mw4q7m3 332 21 of of IN cord-323404-3mw4q7m3 332 22 galactosylceramide galactosylceramide NN cord-323404-3mw4q7m3 332 23 ( ( -LRB- cord-323404-3mw4q7m3 332 24 GalCer galcer VB cord-323404-3mw4q7m3 332 25 ) ) -RRB- cord-323404-3mw4q7m3 332 26 bind bind VB cord-323404-3mw4q7m3 332 27 to to IN cord-323404-3mw4q7m3 332 28 the the DT cord-323404-3mw4q7m3 332 29 V3 V3 NNP cord-323404-3mw4q7m3 332 30 domain domain NN cord-323404-3mw4q7m3 332 31 of of IN cord-323404-3mw4q7m3 332 32 HIV-1 HIV-1 NNP cord-323404-3mw4q7m3 332 33 gp120 gp120 NNP cord-323404-3mw4q7m3 332 34 and and CC cord-323404-3mw4q7m3 332 35 inhibit inhibit VB cord-323404-3mw4q7m3 332 36 HIV-1-induced hiv-1-induce VBN cord-323404-3mw4q7m3 332 37 fusion fusion NN cord-323404-3mw4q7m3 332 38 and and CC cord-323404-3mw4q7m3 332 39 entry entry NN cord-323404-3mw4q7m3 332 40 Lipid Lipid NNP cord-323404-3mw4q7m3 332 41 sorting sorting NN cord-323404-3mw4q7m3 332 42 in in IN cord-323404-3mw4q7m3 332 43 epithelial epithelial JJ cord-323404-3mw4q7m3 332 44 cells cell NNS cord-323404-3mw4q7m3 332 45 Identification identification NN cord-323404-3mw4q7m3 332 46 of of IN cord-323404-3mw4q7m3 332 47 a a DT cord-323404-3mw4q7m3 332 48 common common JJ cord-323404-3mw4q7m3 332 49 sphingolipidbinding sphingolipidbinding NN cord-323404-3mw4q7m3 332 50 domain domain NN cord-323404-3mw4q7m3 332 51 in in IN cord-323404-3mw4q7m3 332 52 Alzheimer Alzheimer NNP cord-323404-3mw4q7m3 332 53 , , , cord-323404-3mw4q7m3 332 54 prion prion NN cord-323404-3mw4q7m3 332 55 , , , cord-323404-3mw4q7m3 332 56 and and CC cord-323404-3mw4q7m3 332 57 HIV-1 HIV-1 NNP cord-323404-3mw4q7m3 332 58 proteins protein NNS cord-323404-3mw4q7m3 332 59 Glycosaminoglycan glycosaminoglycan JJ cord-323404-3mw4q7m3 332 60 sulfation sulfation NN cord-323404-3mw4q7m3 332 61 requirements requirement NNS cord-323404-3mw4q7m3 332 62 for for IN cord-323404-3mw4q7m3 332 63 respiratory respiratory JJ cord-323404-3mw4q7m3 332 64 syncytial syncytial JJ cord-323404-3mw4q7m3 332 65 virus virus NN cord-323404-3mw4q7m3 332 66 infection infection NN cord-323404-3mw4q7m3 332 67 Heparan Heparan NNP cord-323404-3mw4q7m3 332 68 sulfate sulfate NN cord-323404-3mw4q7m3 332 69 : : : cord-323404-3mw4q7m3 332 70 decoding decode VBG cord-323404-3mw4q7m3 332 71 a a DT cord-323404-3mw4q7m3 332 72 dynamic dynamic JJ cord-323404-3mw4q7m3 332 73 multifunctional multifunctional JJ cord-323404-3mw4q7m3 332 74 cell cell NN cord-323404-3mw4q7m3 332 75 regulator regulator NN cord-323404-3mw4q7m3 332 76 An an DT cord-323404-3mw4q7m3 332 77 informative informative JJ cord-323404-3mw4q7m3 332 78 review review NN cord-323404-3mw4q7m3 332 79 on on IN cord-323404-3mw4q7m3 332 80 the the DT cord-323404-3mw4q7m3 332 81 structure structure NN cord-323404-3mw4q7m3 332 82 and and CC cord-323404-3mw4q7m3 332 83 function function NN cord-323404-3mw4q7m3 332 84 of of IN cord-323404-3mw4q7m3 332 85 heparan heparan NN cord-323404-3mw4q7m3 332 86 sulphate sulphate NN cord-323404-3mw4q7m3 332 87 Viral viral JJ cord-323404-3mw4q7m3 332 88 and and CC cord-323404-3mw4q7m3 332 89 cellular cellular JJ cord-323404-3mw4q7m3 332 90 requirements requirement NNS cord-323404-3mw4q7m3 332 91 for for IN cord-323404-3mw4q7m3 332 92 entry entry NN cord-323404-3mw4q7m3 332 93 of of IN cord-323404-3mw4q7m3 332 94 herpes herpes NNP cord-323404-3mw4q7m3 332 95 simplex simplex NNP cord-323404-3mw4q7m3 332 96 virus virus NN cord-323404-3mw4q7m3 332 97 type type NN cord-323404-3mw4q7m3 332 98 1 1 CD cord-323404-3mw4q7m3 332 99 into into IN cord-323404-3mw4q7m3 332 100 primary primary JJ cord-323404-3mw4q7m3 332 101 neuronal neuronal JJ cord-323404-3mw4q7m3 332 102 cells cell NNS cord-323404-3mw4q7m3 332 103 Human human JJ cord-323404-3mw4q7m3 332 104 herpesvirus herpesvirus NN cord-323404-3mw4q7m3 332 105 8 8 CD cord-323404-3mw4q7m3 332 106 envelope envelope NN cord-323404-3mw4q7m3 332 107 glycoprotein glycoprotein VBG cord-323404-3mw4q7m3 332 108 K8.1A k8.1a JJ cord-323404-3mw4q7m3 332 109 interaction interaction NN cord-323404-3mw4q7m3 332 110 with with IN cord-323404-3mw4q7m3 332 111 the the DT cord-323404-3mw4q7m3 332 112 target target NN cord-323404-3mw4q7m3 332 113 cells cell NNS cord-323404-3mw4q7m3 332 114 involves involve VBZ cord-323404-3mw4q7m3 332 115 heparan heparan NN cord-323404-3mw4q7m3 332 116 sulfate sulfate NN cord-323404-3mw4q7m3 332 117 The the DT cord-323404-3mw4q7m3 332 118 fusion fusion NN cord-323404-3mw4q7m3 332 119 glycoprotein glycoprotein NN cord-323404-3mw4q7m3 332 120 of of IN cord-323404-3mw4q7m3 332 121 human human JJ cord-323404-3mw4q7m3 332 122 respiratory respiratory JJ cord-323404-3mw4q7m3 332 123 syncytial syncytial JJ cord-323404-3mw4q7m3 332 124 virus virus NN cord-323404-3mw4q7m3 332 125 facilitates facilitate VBZ cord-323404-3mw4q7m3 332 126 virus virus NN cord-323404-3mw4q7m3 332 127 attachment attachment NN cord-323404-3mw4q7m3 332 128 and and CC cord-323404-3mw4q7m3 332 129 infectivity infectivity NN cord-323404-3mw4q7m3 332 130 via via IN cord-323404-3mw4q7m3 332 131 an an DT cord-323404-3mw4q7m3 332 132 interaction interaction NN cord-323404-3mw4q7m3 332 133 with with IN cord-323404-3mw4q7m3 332 134 cellular cellular JJ cord-323404-3mw4q7m3 332 135 heparan heparan NN cord-323404-3mw4q7m3 332 136 sulfate sulfate NN cord-323404-3mw4q7m3 332 137 Heparan Heparan NNP cord-323404-3mw4q7m3 332 138 sulfate sulfate NN cord-323404-3mw4q7m3 332 139 glycosaminoglycans glycosaminoglycan NNS cord-323404-3mw4q7m3 332 140 are be VBP cord-323404-3mw4q7m3 332 141 receptors receptor NNS cord-323404-3mw4q7m3 332 142 sufficient sufficient JJ cord-323404-3mw4q7m3 332 143 to to TO cord-323404-3mw4q7m3 332 144 mediate mediate VB cord-323404-3mw4q7m3 332 145 the the DT cord-323404-3mw4q7m3 332 146 initial initial JJ cord-323404-3mw4q7m3 332 147 binding binding NN cord-323404-3mw4q7m3 332 148 of of IN cord-323404-3mw4q7m3 332 149 adenovirus adenovirus NN cord-323404-3mw4q7m3 332 150 types type NNS cord-323404-3mw4q7m3 332 151 2 2 CD cord-323404-3mw4q7m3 332 152 and and CC cord-323404-3mw4q7m3 332 153 5 5 CD cord-323404-3mw4q7m3 332 154 Echoviruses echovirus NNS cord-323404-3mw4q7m3 332 155 bind bind VBP cord-323404-3mw4q7m3 332 156 heparan heparan NN cord-323404-3mw4q7m3 332 157 sulfate sulfate NN cord-323404-3mw4q7m3 332 158 at at IN cord-323404-3mw4q7m3 332 159 the the DT cord-323404-3mw4q7m3 332 160 cell cell NN cord-323404-3mw4q7m3 332 161 surface surface NN cord-323404-3mw4q7m3 333 1 Membrane membrane NN cord-323404-3mw4q7m3 333 2 - - HYPH cord-323404-3mw4q7m3 333 3 associated associate VBN cord-323404-3mw4q7m3 333 4 heparan heparan NN cord-323404-3mw4q7m3 333 5 sulfate sulfate NN cord-323404-3mw4q7m3 333 6 proteoglycan proteoglycan NN cord-323404-3mw4q7m3 333 7 is be VBZ cord-323404-3mw4q7m3 333 8 a a DT cord-323404-3mw4q7m3 333 9 receptor receptor NN cord-323404-3mw4q7m3 333 10 for for IN cord-323404-3mw4q7m3 333 11 adenoassociated adenoassociate VBN cord-323404-3mw4q7m3 333 12 virus virus NN cord-323404-3mw4q7m3 333 13 type type NN cord-323404-3mw4q7m3 333 14 2 2 CD cord-323404-3mw4q7m3 333 15 virions virion NNS cord-323404-3mw4q7m3 333 16 Junction Junction NNP cord-323404-3mw4q7m3 333 17 adhesion adhesion NN cord-323404-3mw4q7m3 333 18 molecule molecule NN cord-323404-3mw4q7m3 333 19 is be VBZ cord-323404-3mw4q7m3 333 20 a a DT cord-323404-3mw4q7m3 333 21 receptor receptor NN cord-323404-3mw4q7m3 333 22 for for IN cord-323404-3mw4q7m3 333 23 reovirus reovirus NNP cord-323404-3mw4q7m3 333 24 Human Human NNP cord-323404-3mw4q7m3 333 25 papillomavirus papillomavirus NN cord-323404-3mw4q7m3 333 26 infection infection NN cord-323404-3mw4q7m3 333 27 requires require VBZ cord-323404-3mw4q7m3 333 28 cell cell NN cord-323404-3mw4q7m3 333 29 surface surface NN cord-323404-3mw4q7m3 333 30 heparan heparan NN cord-323404-3mw4q7m3 333 31 sulfate sulfate NN cord-323404-3mw4q7m3 333 32 Role role NN cord-323404-3mw4q7m3 333 33 of of IN cord-323404-3mw4q7m3 333 34 the the DT cord-323404-3mw4q7m3 333 35 cytoplasmic cytoplasmic JJ cord-323404-3mw4q7m3 333 36 domain domain NN cord-323404-3mw4q7m3 333 37 of of IN cord-323404-3mw4q7m3 333 38 the the DT cord-323404-3mw4q7m3 333 39 β β NN cord-323404-3mw4q7m3 333 40 - - HYPH cord-323404-3mw4q7m3 333 41 subunit subunit NN cord-323404-3mw4q7m3 333 42 of of IN cord-323404-3mw4q7m3 333 43 integrin integrin NN cord-323404-3mw4q7m3 334 1 α α NNP cord-323404-3mw4q7m3 334 2 ( ( -LRB- cord-323404-3mw4q7m3 334 3 v v NN cord-323404-3mw4q7m3 334 4 ) ) -RRB- cord-323404-3mw4q7m3 334 5 β β NN cord-323404-3mw4q7m3 334 6 6 6 CD cord-323404-3mw4q7m3 334 7 in in IN cord-323404-3mw4q7m3 334 8 infection infection NN cord-323404-3mw4q7m3 334 9 by by IN cord-323404-3mw4q7m3 334 10 foot foot NN cord-323404-3mw4q7m3 334 11 - - HYPH cord-323404-3mw4q7m3 334 12 and and CC cord-323404-3mw4q7m3 334 13 - - HYPH cord-323404-3mw4q7m3 334 14 mouth mouth NN cord-323404-3mw4q7m3 334 15 disease disease NN cord-323404-3mw4q7m3 334 16 virus virus NN cord-323404-3mw4q7m3 334 17 Initial initial JJ cord-323404-3mw4q7m3 334 18 interaction interaction NN cord-323404-3mw4q7m3 334 19 of of IN cord-323404-3mw4q7m3 334 20 herpes herpes NN cord-323404-3mw4q7m3 334 21 simplex simplex NN cord-323404-3mw4q7m3 334 22 virus virus NN cord-323404-3mw4q7m3 334 23 with with IN cord-323404-3mw4q7m3 334 24 cells cell NNS cord-323404-3mw4q7m3 334 25 is be VBZ cord-323404-3mw4q7m3 334 26 binding bind VBG cord-323404-3mw4q7m3 334 27 to to IN cord-323404-3mw4q7m3 334 28 heparan heparan NN cord-323404-3mw4q7m3 334 29 sulfate sulfate NN cord-323404-3mw4q7m3 334 30 Integrin Integrin NNP cord-323404-3mw4q7m3 334 31 α α NN cord-323404-3mw4q7m3 334 32 ( ( -LRB- cord-323404-3mw4q7m3 334 33 v v NN cord-323404-3mw4q7m3 334 34 ) ) -RRB- cord-323404-3mw4q7m3 334 35 β β NN cord-323404-3mw4q7m3 334 36 ( ( -LRB- cord-323404-3mw4q7m3 334 37 3 3 LS cord-323404-3mw4q7m3 334 38 ) ) -RRB- cord-323404-3mw4q7m3 334 39 mediates mediate VBZ cord-323404-3mw4q7m3 334 40 rotavirus rotavirus JJ cord-323404-3mw4q7m3 334 41 cell cell NN cord-323404-3mw4q7m3 334 42 entry entry NN cord-323404-3mw4q7m3 334 43 RGD RGD NNP cord-323404-3mw4q7m3 334 44 and and CC cord-323404-3mw4q7m3 334 45 other other JJ cord-323404-3mw4q7m3 334 46 recognition recognition NN cord-323404-3mw4q7m3 334 47 sequences sequence NNS cord-323404-3mw4q7m3 334 48 for for IN cord-323404-3mw4q7m3 334 49 integrins integrin NNS cord-323404-3mw4q7m3 334 50 Integrin Integrin NNP cord-323404-3mw4q7m3 334 51 α α NN cord-323404-3mw4q7m3 334 52 3 3 CD cord-323404-3mw4q7m3 334 53 β β NN cord-323404-3mw4q7m3 334 54 1 1 CD cord-323404-3mw4q7m3 334 55 ( ( -LRB- cord-323404-3mw4q7m3 334 56 CD CD NNP cord-323404-3mw4q7m3 334 57 49c/29 49c/29 , cord-323404-3mw4q7m3 334 58 ) ) -RRB- cord-323404-3mw4q7m3 334 59 is be VBZ cord-323404-3mw4q7m3 334 60 a a DT cord-323404-3mw4q7m3 334 61 cellular cellular JJ cord-323404-3mw4q7m3 334 62 receptor receptor NN cord-323404-3mw4q7m3 334 63 for for IN cord-323404-3mw4q7m3 334 64 Kaposi Kaposi NNP cord-323404-3mw4q7m3 334 65 's 's POS cord-323404-3mw4q7m3 334 66 sarcoma sarcoma NN cord-323404-3mw4q7m3 334 67 - - HYPH cord-323404-3mw4q7m3 334 68 associated associate VBN cord-323404-3mw4q7m3 334 69 herpesvirus herpesvirus NN cord-323404-3mw4q7m3 334 70 ( ( -LRB- cord-323404-3mw4q7m3 334 71 KSHV KSHV NNP cord-323404-3mw4q7m3 334 72 / / SYM cord-323404-3mw4q7m3 334 73 HHV-8 HHV-8 NNP cord-323404-3mw4q7m3 334 74 ) ) -RRB- cord-323404-3mw4q7m3 334 75 entry entry NN cord-323404-3mw4q7m3 334 76 into into IN cord-323404-3mw4q7m3 334 77 the the DT cord-323404-3mw4q7m3 334 78 target target NN cord-323404-3mw4q7m3 334 79 cells cell NNS cord-323404-3mw4q7m3 335 1 VLA-2 VLA-2 NNP cord-323404-3mw4q7m3 335 2 ( ( -LRB- cord-323404-3mw4q7m3 336 1 α α NN cord-323404-3mw4q7m3 336 2 2 2 CD cord-323404-3mw4q7m3 336 3 β β NN cord-323404-3mw4q7m3 336 4 1 1 CD cord-323404-3mw4q7m3 336 5 ) ) -RRB- cord-323404-3mw4q7m3 336 6 integrin integrin NNP cord-323404-3mw4q7m3 336 7 promotes promote VBZ cord-323404-3mw4q7m3 336 8 rotavirus rotavirus JJ cord-323404-3mw4q7m3 336 9 entry entry NN cord-323404-3mw4q7m3 336 10 into into IN cord-323404-3mw4q7m3 336 11 cells cell NNS cord-323404-3mw4q7m3 336 12 but but CC cord-323404-3mw4q7m3 336 13 is be VBZ cord-323404-3mw4q7m3 336 14 not not RB cord-323404-3mw4q7m3 336 15 necessary necessary JJ cord-323404-3mw4q7m3 336 16 for for IN cord-323404-3mw4q7m3 336 17 rotavirus rotavirus JJ cord-323404-3mw4q7m3 336 18 attachment attachment NN cord-323404-3mw4q7m3 336 19 Rotavirus Rotavirus NNP cord-323404-3mw4q7m3 336 20 contains contain VBZ cord-323404-3mw4q7m3 336 21 integrin integrin NN cord-323404-3mw4q7m3 336 22 ligand ligand NN cord-323404-3mw4q7m3 336 23 sequences sequence NNS cord-323404-3mw4q7m3 336 24 and and CC cord-323404-3mw4q7m3 336 25 a a DT cord-323404-3mw4q7m3 336 26 disintegrin disintegrin NN cord-323404-3mw4q7m3 336 27 - - HYPH cord-323404-3mw4q7m3 336 28 like like JJ cord-323404-3mw4q7m3 336 29 domain domain NN cord-323404-3mw4q7m3 336 30 that that WDT cord-323404-3mw4q7m3 336 31 are be VBP cord-323404-3mw4q7m3 336 32 implicated implicate VBN cord-323404-3mw4q7m3 336 33 in in IN cord-323404-3mw4q7m3 336 34 virus virus NN cord-323404-3mw4q7m3 336 35 entry entry NN cord-323404-3mw4q7m3 336 36 into into IN cord-323404-3mw4q7m3 336 37 cells cell NNS cord-323404-3mw4q7m3 336 38 Entry Entry NNP cord-323404-3mw4q7m3 336 39 of of IN cord-323404-3mw4q7m3 336 40 rotaviruses rotaviruses NNP cord-323404-3mw4q7m3 336 41 is be VBZ cord-323404-3mw4q7m3 336 42 a a DT cord-323404-3mw4q7m3 336 43 multistep multistep JJ cord-323404-3mw4q7m3 336 44 process process NN cord-323404-3mw4q7m3 336 45 Adenovirus Adenovirus NNP cord-323404-3mw4q7m3 336 46 endocytosis endocytosis NN cord-323404-3mw4q7m3 336 47 via via IN cord-323404-3mw4q7m3 337 1 α α NNP cord-323404-3mw4q7m3 337 2 ( ( -LRB- cord-323404-3mw4q7m3 337 3 v v NN cord-323404-3mw4q7m3 337 4 ) ) -RRB- cord-323404-3mw4q7m3 337 5 integrins integrin NNS cord-323404-3mw4q7m3 337 6 requires require VBZ cord-323404-3mw4q7m3 337 7 phosphoinositide-3-OH phosphoinositide-3-OH NNP cord-323404-3mw4q7m3 337 8 kinase kinase NNP cord-323404-3mw4q7m3 337 9 Internalization Internalization NNP cord-323404-3mw4q7m3 337 10 of of IN cord-323404-3mw4q7m3 337 11 echovirus echovirus NNP cord-323404-3mw4q7m3 337 12 1 1 CD cord-323404-3mw4q7m3 337 13 in in IN cord-323404-3mw4q7m3 337 14 caveolae caveolae NNP cord-323404-3mw4q7m3 338 1 Viral viral JJ cord-323404-3mw4q7m3 338 2 evolution evolution NN cord-323404-3mw4q7m3 338 3 toward toward IN cord-323404-3mw4q7m3 338 4 change change NN cord-323404-3mw4q7m3 338 5 in in IN cord-323404-3mw4q7m3 338 6 receptor receptor NN cord-323404-3mw4q7m3 338 7 usage usage NN cord-323404-3mw4q7m3 338 8 : : : cord-323404-3mw4q7m3 338 9 adaptation adaptation NN cord-323404-3mw4q7m3 338 10 of of IN cord-323404-3mw4q7m3 338 11 a a DT cord-323404-3mw4q7m3 338 12 major major JJ cord-323404-3mw4q7m3 338 13 group group NN cord-323404-3mw4q7m3 338 14 of of IN cord-323404-3mw4q7m3 338 15 human human JJ cord-323404-3mw4q7m3 338 16 rhinovirus rhinovirus NN cord-323404-3mw4q7m3 338 17 to to TO cord-323404-3mw4q7m3 338 18 grow grow VB cord-323404-3mw4q7m3 338 19 in in IN cord-323404-3mw4q7m3 338 20 ICAM-1-negative icam-1-negative NN cord-323404-3mw4q7m3 338 21 cells cell NNS cord-323404-3mw4q7m3 339 1 This this DT cord-323404-3mw4q7m3 339 2 characterization characterization NN cord-323404-3mw4q7m3 339 3 of of IN cord-323404-3mw4q7m3 339 4 the the DT cord-323404-3mw4q7m3 339 5 cellular cellular JJ cord-323404-3mw4q7m3 339 6 function function NN cord-323404-3mw4q7m3 339 7 of of IN cord-323404-3mw4q7m3 339 8 the the DT cord-323404-3mw4q7m3 339 9 coxsackievirus coxsackievirus NNP cord-323404-3mw4q7m3 339 10 and and CC cord-323404-3mw4q7m3 339 11 adenovirus adenovirus NN cord-323404-3mw4q7m3 339 12 receptor receptor NN cord-323404-3mw4q7m3 339 13 ( ( -LRB- cord-323404-3mw4q7m3 339 14 CAR car NN cord-323404-3mw4q7m3 339 15 ) ) -RRB- cord-323404-3mw4q7m3 339 16 sheds shed VBZ cord-323404-3mw4q7m3 339 17 light light NN cord-323404-3mw4q7m3 339 18 on on IN cord-323404-3mw4q7m3 339 19 the the DT cord-323404-3mw4q7m3 339 20 polarity polarity NN cord-323404-3mw4q7m3 339 21 of of IN cord-323404-3mw4q7m3 339 22 the the DT cord-323404-3mw4q7m3 339 23 entry entry NN cord-323404-3mw4q7m3 339 24 of of IN cord-323404-3mw4q7m3 339 25 these these DT cord-323404-3mw4q7m3 339 26 viruses virus NNS cord-323404-3mw4q7m3 339 27 Entry Entry NNP cord-323404-3mw4q7m3 339 28 of of IN cord-323404-3mw4q7m3 339 29 α α NNP cord-323404-3mw4q7m3 339 30 - - HYPH cord-323404-3mw4q7m3 339 31 herpesviruses herpesviruses NNP cord-323404-3mw4q7m3 339 32 mediated mediate VBN cord-323404-3mw4q7m3 339 33 by by IN cord-323404-3mw4q7m3 339 34 poliovirus poliovirus NN cord-323404-3mw4q7m3 339 35 receptor receptor NN cord-323404-3mw4q7m3 339 36 - - HYPH cord-323404-3mw4q7m3 339 37 related relate VBN cord-323404-3mw4q7m3 339 38 protein protein NN cord-323404-3mw4q7m3 339 39 1 1 CD cord-323404-3mw4q7m3 339 40 and and CC cord-323404-3mw4q7m3 339 41 poliovirus poliovirus NN cord-323404-3mw4q7m3 339 42 receptor receptor NN cord-323404-3mw4q7m3 339 43 Coronavirus Coronavirus NNP cord-323404-3mw4q7m3 339 44 infection infection NN cord-323404-3mw4q7m3 339 45 of of IN cord-323404-3mw4q7m3 339 46 polarized polarized JJ cord-323404-3mw4q7m3 339 47 epithelial epithelial JJ cord-323404-3mw4q7m3 339 48 cells cell NNS cord-323404-3mw4q7m3 339 49 Quaternary quaternary JJ cord-323404-3mw4q7m3 339 50 structure structure NN cord-323404-3mw4q7m3 339 51 of of IN cord-323404-3mw4q7m3 339 52 coronavirus coronavirus NN cord-323404-3mw4q7m3 339 53 spikes spike NNS cord-323404-3mw4q7m3 339 54 in in IN cord-323404-3mw4q7m3 339 55 complex complex NN cord-323404-3mw4q7m3 339 56 with with IN cord-323404-3mw4q7m3 339 57 carcinoembryonic carcinoembryonic NNP cord-323404-3mw4q7m3 339 58 antigen antigen NN cord-323404-3mw4q7m3 339 59 - - HYPH cord-323404-3mw4q7m3 339 60 related relate VBN cord-323404-3mw4q7m3 339 61 cell cell NN cord-323404-3mw4q7m3 339 62 adhesion adhesion NN cord-323404-3mw4q7m3 339 63 molecule molecule NN cord-323404-3mw4q7m3 340 1 cellular cellular JJ cord-323404-3mw4q7m3 340 2 receptors receptor NNS cord-323404-3mw4q7m3 340 3 Assymetric Assymetric NNP cord-323404-3mw4q7m3 340 4 budding bud VBG cord-323404-3mw4q7m3 340 5 of of IN cord-323404-3mw4q7m3 340 6 viruses virus NNS cord-323404-3mw4q7m3 340 7 in in IN cord-323404-3mw4q7m3 340 8 epithelial epithelial JJ cord-323404-3mw4q7m3 340 9 cells cell NNS cord-323404-3mw4q7m3 340 10 : : : cord-323404-3mw4q7m3 341 1 a a DT cord-323404-3mw4q7m3 341 2 model model NN cord-323404-3mw4q7m3 341 3 system system NN cord-323404-3mw4q7m3 341 4 for for IN cord-323404-3mw4q7m3 341 5 study study NN cord-323404-3mw4q7m3 341 6 of of IN cord-323404-3mw4q7m3 341 7 epithelial epithelial JJ cord-323404-3mw4q7m3 341 8 polarity polarity NN cord-323404-3mw4q7m3 341 9 Interaction Interaction NNP cord-323404-3mw4q7m3 341 10 of of IN cord-323404-3mw4q7m3 341 11 the the DT cord-323404-3mw4q7m3 341 12 poliovirus poliovirus NN cord-323404-3mw4q7m3 341 13 receptor receptor NN cord-323404-3mw4q7m3 341 14 with with IN cord-323404-3mw4q7m3 341 15 poliovirus poliovirus NN cord-323404-3mw4q7m3 341 16 Endocytic Endocytic NNP cord-323404-3mw4q7m3 341 17 traffic traffic NN cord-323404-3mw4q7m3 341 18 in in IN cord-323404-3mw4q7m3 341 19 polarized polarized JJ cord-323404-3mw4q7m3 341 20 epithelial epithelial JJ cord-323404-3mw4q7m3 341 21 cells cell NNS cord-323404-3mw4q7m3 341 22 : : : cord-323404-3mw4q7m3 341 23 role role NN cord-323404-3mw4q7m3 341 24 of of IN cord-323404-3mw4q7m3 341 25 the the DT cord-323404-3mw4q7m3 341 26 actin actin NN cord-323404-3mw4q7m3 341 27 and and CC cord-323404-3mw4q7m3 341 28 microtubule microtubule NN cord-323404-3mw4q7m3 341 29 cytoskeleton cytoskeleton NN cord-323404-3mw4q7m3 341 30 GPI GPI NNP cord-323404-3mw4q7m3 341 31 - - HYPH cord-323404-3mw4q7m3 341 32 anchored anchor VBN cord-323404-3mw4q7m3 341 33 proteins protein NNS cord-323404-3mw4q7m3 341 34 are be VBP cord-323404-3mw4q7m3 341 35 delivered deliver VBN cord-323404-3mw4q7m3 341 36 to to IN cord-323404-3mw4q7m3 341 37 recycling recycling NN cord-323404-3mw4q7m3 341 38 endosomes endosome NNS cord-323404-3mw4q7m3 341 39 via via IN cord-323404-3mw4q7m3 341 40 a a DT cord-323404-3mw4q7m3 341 41 distinct distinct JJ cord-323404-3mw4q7m3 341 42 cdc42-regulated cdc42-regulated JJ cord-323404-3mw4q7m3 341 43 , , , cord-323404-3mw4q7m3 341 44 clathrinindependent clathrinindependent NN cord-323404-3mw4q7m3 341 45 pinocytic pinocytic NNP cord-323404-3mw4q7m3 341 46 pathway pathway NN cord-323404-3mw4q7m3 341 47 Conversion Conversion NNP cord-323404-3mw4q7m3 341 48 by by IN cord-323404-3mw4q7m3 341 49 Peyer Peyer NNP cord-323404-3mw4q7m3 341 50 's 's POS cord-323404-3mw4q7m3 341 51 patch patch NN cord-323404-3mw4q7m3 341 52 lymphocytes lymphocyte NNS cord-323404-3mw4q7m3 341 53 of of IN cord-323404-3mw4q7m3 341 54 human human JJ cord-323404-3mw4q7m3 341 55 enterocytes enterocyte NNS cord-323404-3mw4q7m3 341 56 into into IN cord-323404-3mw4q7m3 341 57 M M NNP cord-323404-3mw4q7m3 341 58 cells cell NNS cord-323404-3mw4q7m3 341 59 that that WDT cord-323404-3mw4q7m3 341 60 transport transport NN cord-323404-3mw4q7m3 341 61 bacteria bacteria NNS cord-323404-3mw4q7m3 342 1 The the DT cord-323404-3mw4q7m3 342 2 role role NN cord-323404-3mw4q7m3 342 3 of of IN cord-323404-3mw4q7m3 342 4 cell cell NN cord-323404-3mw4q7m3 342 5 - - HYPH cord-323404-3mw4q7m3 342 6 to to IN cord-323404-3mw4q7m3 342 7 - - HYPH cord-323404-3mw4q7m3 342 8 cell cell NN cord-323404-3mw4q7m3 342 9 transmission transmission NN cord-323404-3mw4q7m3 342 10 in in IN cord-323404-3mw4q7m3 342 11 HIV HIV NNP cord-323404-3mw4q7m3 342 12 infection infection NN cord-323404-3mw4q7m3 342 13 Cell cell NN cord-323404-3mw4q7m3 342 14 - - HYPH cord-323404-3mw4q7m3 342 15 to to IN cord-323404-3mw4q7m3 342 16 - - HYPH cord-323404-3mw4q7m3 342 17 cell cell NN cord-323404-3mw4q7m3 342 18 contact contact NN cord-323404-3mw4q7m3 342 19 as as IN cord-323404-3mw4q7m3 342 20 an an DT cord-323404-3mw4q7m3 342 21 efficient efficient JJ cord-323404-3mw4q7m3 342 22 mode mode NN cord-323404-3mw4q7m3 342 23 of of IN cord-323404-3mw4q7m3 342 24 Epstein Epstein NNP cord-323404-3mw4q7m3 342 25 - - HYPH cord-323404-3mw4q7m3 342 26 Barr Barr NNP cord-323404-3mw4q7m3 342 27 virus virus NN cord-323404-3mw4q7m3 342 28 infection infection NN cord-323404-3mw4q7m3 342 29 of of IN cord-323404-3mw4q7m3 342 30 diverse diverse JJ cord-323404-3mw4q7m3 342 31 human human JJ cord-323404-3mw4q7m3 342 32 epithelial epithelial JJ cord-323404-3mw4q7m3 342 33 cells cell NNS cord-323404-3mw4q7m3 342 34 Biological biological JJ cord-323404-3mw4q7m3 342 35 parameters parameter NNS cord-323404-3mw4q7m3 342 36 of of IN cord-323404-3mw4q7m3 342 37 HIV-1 HIV-1 NNP cord-323404-3mw4q7m3 342 38 infection infection NN cord-323404-3mw4q7m3 342 39 in in IN cord-323404-3mw4q7m3 342 40 primary primary JJ cord-323404-3mw4q7m3 342 41 intestinal intestinal JJ cord-323404-3mw4q7m3 342 42 lymphocytes lymphocyte NNS cord-323404-3mw4q7m3 342 43 Constitutive constitutive JJ cord-323404-3mw4q7m3 342 44 expression expression NN cord-323404-3mw4q7m3 342 45 of of IN cord-323404-3mw4q7m3 342 46 stromal stromal NN cord-323404-3mw4q7m3 342 47 derived derive VBN cord-323404-3mw4q7m3 342 48 factor-1 factor-1 NNP cord-323404-3mw4q7m3 342 49 by by IN cord-323404-3mw4q7m3 342 50 mucosal mucosal JJ cord-323404-3mw4q7m3 342 51 epithelia epithelium NNS cord-323404-3mw4q7m3 343 1 Intercellular Intercellular NNP cord-323404-3mw4q7m3 343 2 trafficking trafficking NN cord-323404-3mw4q7m3 343 3 and and CC cord-323404-3mw4q7m3 343 4 protein protein NN cord-323404-3mw4q7m3 343 5 delivery delivery NN cord-323404-3mw4q7m3 343 6 by by IN cord-323404-3mw4q7m3 343 7 a a DT cord-323404-3mw4q7m3 343 8 herpesvirus herpesvirus NN cord-323404-3mw4q7m3 343 9 structural structural JJ cord-323404-3mw4q7m3 343 10 protein protein NN cord-323404-3mw4q7m3 343 11 Role role NN cord-323404-3mw4q7m3 343 12 of of IN cord-323404-3mw4q7m3 343 13 tight tight JJ cord-323404-3mw4q7m3 343 14 junctions junction NNS cord-323404-3mw4q7m3 343 15 of of IN cord-323404-3mw4q7m3 343 16 polarized polarized JJ cord-323404-3mw4q7m3 343 17 epithelial epithelial JJ cord-323404-3mw4q7m3 343 18 MDCK MDCK NNP cord-323404-3mw4q7m3 343 19 cells cell NNS cord-323404-3mw4q7m3 343 20 in in IN cord-323404-3mw4q7m3 343 21 the the DT cord-323404-3mw4q7m3 343 22 replication replication NN cord-323404-3mw4q7m3 343 23 of of IN cord-323404-3mw4q7m3 343 24 herpes herpes NNP cord-323404-3mw4q7m3 343 25 simplex simplex NNP cord-323404-3mw4q7m3 343 26 virus virus NN cord-323404-3mw4q7m3 343 27 type type NN cord-323404-3mw4q7m3 343 28 1 1 CD cord-323404-3mw4q7m3 344 1 The the DT cord-323404-3mw4q7m3 344 2 spread spread NN cord-323404-3mw4q7m3 344 3 of of IN cord-323404-3mw4q7m3 344 4 herpes herpes NN cord-323404-3mw4q7m3 344 5 simplex simplex NNP cord-323404-3mw4q7m3 344 6 virus virus NN cord-323404-3mw4q7m3 344 7 type type NN cord-323404-3mw4q7m3 344 8 1 1 CD cord-323404-3mw4q7m3 344 9 from from IN cord-323404-3mw4q7m3 344 10 trigeminal trigeminal JJ cord-323404-3mw4q7m3 344 11 neurons neuron NNS cord-323404-3mw4q7m3 344 12 to to IN cord-323404-3mw4q7m3 344 13 the the DT cord-323404-3mw4q7m3 344 14 murine murine JJ cord-323404-3mw4q7m3 344 15 cornea cornea NN cord-323404-3mw4q7m3 344 16 : : : cord-323404-3mw4q7m3 344 17 an an DT cord-323404-3mw4q7m3 344 18 immunoelectron immunoelectron NNP cord-323404-3mw4q7m3 344 19 microscopy microscopy NN cord-323404-3mw4q7m3 344 20 study study NN cord-323404-3mw4q7m3 344 21 Neutrophil Neutrophil NNP cord-323404-3mw4q7m3 344 22 chemotaxis chemotaxis NN cord-323404-3mw4q7m3 344 23 induced induce VBN cord-323404-3mw4q7m3 344 24 by by IN cord-323404-3mw4q7m3 344 25 corneal corneal JJ cord-323404-3mw4q7m3 344 26 epithelial epithelial JJ cord-323404-3mw4q7m3 344 27 cells cell NNS cord-323404-3mw4q7m3 344 28 after after IN cord-323404-3mw4q7m3 344 29 herpes herpes NN cord-323404-3mw4q7m3 344 30 simplex simplex NNP cord-323404-3mw4q7m3 344 31 virus virus NN cord-323404-3mw4q7m3 344 32 type type NN cord-323404-3mw4q7m3 344 33 1 1 CD cord-323404-3mw4q7m3 344 34 infection infection NN cord-323404-3mw4q7m3 344 35 Human human JJ cord-323404-3mw4q7m3 344 36 cytomegalovirus cytomegalovirus NN cord-323404-3mw4q7m3 344 37 infects infect VBZ cord-323404-3mw4q7m3 344 38 Caco-2 caco-2 NN cord-323404-3mw4q7m3 344 39 intestinal intestinal JJ cord-323404-3mw4q7m3 344 40 epithelial epithelial JJ cord-323404-3mw4q7m3 344 41 cells cell NNS cord-323404-3mw4q7m3 344 42 basolaterally basolaterally RB cord-323404-3mw4q7m3 344 43 regardless regardless RB cord-323404-3mw4q7m3 344 44 of of IN cord-323404-3mw4q7m3 344 45 the the DT cord-323404-3mw4q7m3 344 46 differentiation differentiation NN cord-323404-3mw4q7m3 344 47 state state NN cord-323404-3mw4q7m3 344 48 Patterned pattern VBN cord-323404-3mw4q7m3 344 49 entry entry NN cord-323404-3mw4q7m3 344 50 and and CC cord-323404-3mw4q7m3 344 51 egress egress NN cord-323404-3mw4q7m3 344 52 by by IN cord-323404-3mw4q7m3 344 53 Epstein Epstein NNP cord-323404-3mw4q7m3 344 54 - - HYPH cord-323404-3mw4q7m3 344 55 Barr Barr NNP cord-323404-3mw4q7m3 344 56 virus virus NN cord-323404-3mw4q7m3 344 57 in in IN cord-323404-3mw4q7m3 344 58 polarized polarized JJ cord-323404-3mw4q7m3 344 59 CR2-positive cr2-positive JJ cord-323404-3mw4q7m3 344 60 epithelial epithelial JJ cord-323404-3mw4q7m3 344 61 cells cell NNS cord-323404-3mw4q7m3 344 62 Epstein Epstein NNP cord-323404-3mw4q7m3 344 63 - - HYPH cord-323404-3mw4q7m3 344 64 Barr Barr NNP cord-323404-3mw4q7m3 344 65 virus virus NN cord-323404-3mw4q7m3 345 1 gH gH NNP cord-323404-3mw4q7m3 345 2 is be VBZ cord-323404-3mw4q7m3 345 3 essential essential JJ cord-323404-3mw4q7m3 345 4 for for IN cord-323404-3mw4q7m3 345 5 penetration penetration NN cord-323404-3mw4q7m3 345 6 of of IN cord-323404-3mw4q7m3 345 7 B b NN cord-323404-3mw4q7m3 345 8 cells cell NNS cord-323404-3mw4q7m3 345 9 but but CC cord-323404-3mw4q7m3 345 10 also also RB cord-323404-3mw4q7m3 345 11 plays play VBZ cord-323404-3mw4q7m3 345 12 a a DT cord-323404-3mw4q7m3 345 13 role role NN cord-323404-3mw4q7m3 345 14 in in IN cord-323404-3mw4q7m3 345 15 attachment attachment NN cord-323404-3mw4q7m3 345 16 of of IN cord-323404-3mw4q7m3 345 17 virus virus NN cord-323404-3mw4q7m3 345 18 to to TO cord-323404-3mw4q7m3 345 19 epithelial epithelial JJ cord-323404-3mw4q7m3 345 20 cells cell NNS cord-323404-3mw4q7m3 345 21 Vaccinia vaccinia NN cord-323404-3mw4q7m3 345 22 virus virus NN cord-323404-3mw4q7m3 345 23 preferentially preferentially RB cord-323404-3mw4q7m3 345 24 enters enter VBZ cord-323404-3mw4q7m3 345 25 polarized polarized JJ cord-323404-3mw4q7m3 345 26 epithelial epithelial JJ cord-323404-3mw4q7m3 345 27 cells cell NNS cord-323404-3mw4q7m3 345 28 through through IN cord-323404-3mw4q7m3 345 29 the the DT cord-323404-3mw4q7m3 345 30 basolateral basolateral JJ cord-323404-3mw4q7m3 345 31 surface surface NN cord-323404-3mw4q7m3 345 32 Specific specific JJ cord-323404-3mw4q7m3 345 33 interaction interaction NN cord-323404-3mw4q7m3 345 34 of of IN cord-323404-3mw4q7m3 345 35 HIV-1 HIV-1 NNP cord-323404-3mw4q7m3 345 36 and and CC cord-323404-3mw4q7m3 345 37 HIV-2 HIV-2 NNP cord-323404-3mw4q7m3 345 38 surface surface NN cord-323404-3mw4q7m3 345 39 envelope envelope NN cord-323404-3mw4q7m3 345 40 glycoproteins glycoprotein NNS cord-323404-3mw4q7m3 345 41 with with IN cord-323404-3mw4q7m3 345 42 monolayers monolayer NNS cord-323404-3mw4q7m3 345 43 of of IN cord-323404-3mw4q7m3 345 44 galactosylceramide galactosylceramide NNP cord-323404-3mw4q7m3 345 45 and and CC cord-323404-3mw4q7m3 345 46 ganglioside ganglioside NN cord-323404-3mw4q7m3 345 47 GM3 GM3 NNP cord-323404-3mw4q7m3 345 48 Respiratory respiratory JJ cord-323404-3mw4q7m3 345 49 syncytial syncytial JJ cord-323404-3mw4q7m3 345 50 virus virus NN cord-323404-3mw4q7m3 345 51 induces induce VBZ cord-323404-3mw4q7m3 345 52 selective selective JJ cord-323404-3mw4q7m3 345 53 production production NN cord-323404-3mw4q7m3 345 54 of of IN cord-323404-3mw4q7m3 345 55 the the DT cord-323404-3mw4q7m3 345 56 chemokine chemokine NN cord-323404-3mw4q7m3 345 57 RANTES rante NNS cord-323404-3mw4q7m3 345 58 by by IN cord-323404-3mw4q7m3 345 59 upper upper JJ cord-323404-3mw4q7m3 345 60 airway airway NN cord-323404-3mw4q7m3 345 61 epithelial epithelial JJ cord-323404-3mw4q7m3 345 62 cells cell NNS cord-323404-3mw4q7m3 345 63 Respiratory respiratory JJ cord-323404-3mw4q7m3 345 64 syncytial syncytial JJ cord-323404-3mw4q7m3 345 65 virus virus NN cord-323404-3mw4q7m3 345 66 with with IN cord-323404-3mw4q7m3 345 67 the the DT cord-323404-3mw4q7m3 345 68 fusion fusion NN cord-323404-3mw4q7m3 345 69 protein protein NN cord-323404-3mw4q7m3 345 70 as as IN cord-323404-3mw4q7m3 345 71 its -PRON- PRP$ cord-323404-3mw4q7m3 345 72 only only JJ cord-323404-3mw4q7m3 345 73 viral viral JJ cord-323404-3mw4q7m3 345 74 glycoprotein glycoprotein NN cord-323404-3mw4q7m3 345 75 is be VBZ cord-323404-3mw4q7m3 345 76 less less RBR cord-323404-3mw4q7m3 345 77 dependent dependent JJ cord-323404-3mw4q7m3 345 78 on on IN cord-323404-3mw4q7m3 345 79 cellular cellular JJ cord-323404-3mw4q7m3 345 80 glycosaminoglycans glycosaminoglycan NNS cord-323404-3mw4q7m3 345 81 for for IN cord-323404-3mw4q7m3 345 82 attachment attachment NN cord-323404-3mw4q7m3 345 83 than than IN cord-323404-3mw4q7m3 345 84 complete complete JJ cord-323404-3mw4q7m3 345 85 virus virus NN cord-323404-3mw4q7m3 345 86 Immunocytochemical Immunocytochemical NNP cord-323404-3mw4q7m3 345 87 colocalization colocalization NN cord-323404-3mw4q7m3 345 88 of of IN cord-323404-3mw4q7m3 345 89 specific specific JJ cord-323404-3mw4q7m3 345 90 immunoglobulin immunoglobulin NN cord-323404-3mw4q7m3 345 91 A a NN cord-323404-3mw4q7m3 345 92 with with IN cord-323404-3mw4q7m3 345 93 Sendai Sendai NNP cord-323404-3mw4q7m3 345 94 virus virus NN cord-323404-3mw4q7m3 345 95 protein protein NN cord-323404-3mw4q7m3 345 96 in in IN cord-323404-3mw4q7m3 345 97 infected infected JJ cord-323404-3mw4q7m3 345 98 polarized polarized JJ cord-323404-3mw4q7m3 345 99 epithelium epithelium NN cord-323404-3mw4q7m3 345 100 Polarized polarized JJ cord-323404-3mw4q7m3 345 101 budding budding NN cord-323404-3mw4q7m3 345 102 of of IN cord-323404-3mw4q7m3 345 103 measles measle NNS cord-323404-3mw4q7m3 345 104 virus virus NN cord-323404-3mw4q7m3 345 105 is be VBZ cord-323404-3mw4q7m3 345 106 not not RB cord-323404-3mw4q7m3 345 107 determined determine VBN cord-323404-3mw4q7m3 345 108 by by IN cord-323404-3mw4q7m3 345 109 viral viral JJ cord-323404-3mw4q7m3 345 110 surface surface NN cord-323404-3mw4q7m3 345 111 glycoproteins glycoprotein NNS cord-323404-3mw4q7m3 345 112 Measles Measles NNP cord-323404-3mw4q7m3 345 113 virus virus NN cord-323404-3mw4q7m3 345 114 matrix matrix NN cord-323404-3mw4q7m3 345 115 protein protein NN cord-323404-3mw4q7m3 345 116 specifies specify VBZ cord-323404-3mw4q7m3 345 117 apical apical JJ cord-323404-3mw4q7m3 345 118 virus virus NN cord-323404-3mw4q7m3 345 119 release release NN cord-323404-3mw4q7m3 345 120 and and CC cord-323404-3mw4q7m3 345 121 glycoprotein glycoprotein NN cord-323404-3mw4q7m3 345 122 sorting sort VBG cord-323404-3mw4q7m3 345 123 in in IN cord-323404-3mw4q7m3 345 124 epithelial epithelial JJ cord-323404-3mw4q7m3 345 125 cells cell NNS cord-323404-3mw4q7m3 345 126 Identification identification NN cord-323404-3mw4q7m3 345 127 of of IN cord-323404-3mw4q7m3 345 128 the the DT cord-323404-3mw4q7m3 345 129 α α NN cord-323404-3mw4q7m3 345 130 6 6 CD cord-323404-3mw4q7m3 345 131 integrin integrin NN cord-323404-3mw4q7m3 345 132 as as IN cord-323404-3mw4q7m3 345 133 a a DT cord-323404-3mw4q7m3 345 134 candidate candidate NN cord-323404-3mw4q7m3 345 135 receptor receptor NN cord-323404-3mw4q7m3 345 136 for for IN cord-323404-3mw4q7m3 345 137 papillomaviruses papillomaviruses NNP cord-323404-3mw4q7m3 345 138 Influenza Influenza NNP cord-323404-3mw4q7m3 345 139 virus virus NN cord-323404-3mw4q7m3 345 140 assembly assembly NN cord-323404-3mw4q7m3 345 141 and and CC cord-323404-3mw4q7m3 346 1 lipid lipid NNP cord-323404-3mw4q7m3 346 2 raft raft NN cord-323404-3mw4q7m3 346 3 microdomains microdomains NNP cord-323404-3mw4q7m3 346 4 : : : cord-323404-3mw4q7m3 347 1 a a DT cord-323404-3mw4q7m3 347 2 role role NN cord-323404-3mw4q7m3 347 3 for for IN cord-323404-3mw4q7m3 347 4 the the DT cord-323404-3mw4q7m3 347 5 cytoplasmic cytoplasmic JJ cord-323404-3mw4q7m3 347 6 tails tail NNS cord-323404-3mw4q7m3 347 7 of of IN cord-323404-3mw4q7m3 347 8 the the DT cord-323404-3mw4q7m3 347 9 spike spike NN cord-323404-3mw4q7m3 347 10 glycoproteins glycoprotein VBZ cord-323404-3mw4q7m3 347 11 Vesicular Vesicular NNP cord-323404-3mw4q7m3 347 12 stomatitis stomatitis NN cord-323404-3mw4q7m3 347 13 virus virus NN cord-323404-3mw4q7m3 347 14 glycoprotein glycoprotein NN cord-323404-3mw4q7m3 347 15 does do VBZ cord-323404-3mw4q7m3 347 16 not not RB cord-323404-3mw4q7m3 347 17 determine determine VB cord-323404-3mw4q7m3 347 18 the the DT cord-323404-3mw4q7m3 347 19 site site NN cord-323404-3mw4q7m3 347 20 of of IN cord-323404-3mw4q7m3 347 21 virus virus NN cord-323404-3mw4q7m3 347 22 release release NN cord-323404-3mw4q7m3 347 23 in in IN cord-323404-3mw4q7m3 347 24 polarized polarized JJ cord-323404-3mw4q7m3 347 25 epithelial epithelial JJ cord-323404-3mw4q7m3 347 26 cells cell NNS cord-323404-3mw4q7m3 347 27 Rotavirus rotavirus NN cord-323404-3mw4q7m3 347 28 infection infection NN cord-323404-3mw4q7m3 347 29 induces induce VBZ cord-323404-3mw4q7m3 347 30 cytoskeleton cytoskeleton VBZ cord-323404-3mw4q7m3 347 31 disorganization disorganization NN cord-323404-3mw4q7m3 347 32 in in IN cord-323404-3mw4q7m3 347 33 human human JJ cord-323404-3mw4q7m3 347 34 intestinal intestinal JJ cord-323404-3mw4q7m3 347 35 epithelial epithelial JJ cord-323404-3mw4q7m3 347 36 cells cell NNS cord-323404-3mw4q7m3 347 37 : : : cord-323404-3mw4q7m3 347 38 implication implication NN cord-323404-3mw4q7m3 347 39 of of IN cord-323404-3mw4q7m3 347 40 an an DT cord-323404-3mw4q7m3 347 41 increase increase NN cord-323404-3mw4q7m3 347 42 in in IN cord-323404-3mw4q7m3 347 43 intracellular intracellular JJ cord-323404-3mw4q7m3 347 44 calcium calcium NN cord-323404-3mw4q7m3 347 45 concentration concentration NN cord-323404-3mw4q7m3 347 46 Rotavirus rotavirus NN cord-323404-3mw4q7m3 347 47 infection infection NN cord-323404-3mw4q7m3 347 48 of of IN cord-323404-3mw4q7m3 347 49 cultured cultured JJ cord-323404-3mw4q7m3 347 50 intestinal intestinal JJ cord-323404-3mw4q7m3 347 51 epithelial epithelial JJ cord-323404-3mw4q7m3 347 52 cells cell NNS cord-323404-3mw4q7m3 347 53 induces induce VBZ cord-323404-3mw4q7m3 347 54 secretion secretion NN cord-323404-3mw4q7m3 347 55 of of IN cord-323404-3mw4q7m3 347 56 CXC CXC NNP cord-323404-3mw4q7m3 347 57 and and CC cord-323404-3mw4q7m3 347 58 CC CC NNP cord-323404-3mw4q7m3 347 59 chemokines chemokine NNS cord-323404-3mw4q7m3 347 60 Reovirus Reovirus NNP cord-323404-3mw4q7m3 347 61 receptors receptor NNS cord-323404-3mw4q7m3 347 62 and and CC cord-323404-3mw4q7m3 347 63 apoptosis apoptosis NN cord-323404-3mw4q7m3 347 64 Identification identification NN cord-323404-3mw4q7m3 347 65 of of IN cord-323404-3mw4q7m3 347 66 carbohydrate carbohydrate NN cord-323404-3mw4q7m3 347 67 - - HYPH cord-323404-3mw4q7m3 347 68 binding bind VBG cord-323404-3mw4q7m3 347 69 domains domain NNS cord-323404-3mw4q7m3 347 70 in in IN cord-323404-3mw4q7m3 347 71 the the DT cord-323404-3mw4q7m3 347 72 attachment attachment NN cord-323404-3mw4q7m3 347 73 proteins protein NNS cord-323404-3mw4q7m3 347 74 of of IN cord-323404-3mw4q7m3 347 75 type type NN cord-323404-3mw4q7m3 347 76 1 1 CD cord-323404-3mw4q7m3 347 77 and and CC cord-323404-3mw4q7m3 347 78 type type NN cord-323404-3mw4q7m3 347 79 3 3 CD cord-323404-3mw4q7m3 347 80 reoviruses reovirus NNS cord-323404-3mw4q7m3 347 81 Retargeting retargete VBG cord-323404-3mw4q7m3 347 82 the the DT cord-323404-3mw4q7m3 347 83 coxsackievirus coxsackievirus NN cord-323404-3mw4q7m3 347 84 and and CC cord-323404-3mw4q7m3 347 85 adenovirus adenovirus NN cord-323404-3mw4q7m3 347 86 receptor receptor NN cord-323404-3mw4q7m3 347 87 to to IN cord-323404-3mw4q7m3 347 88 the the DT cord-323404-3mw4q7m3 347 89 apical apical JJ cord-323404-3mw4q7m3 347 90 surface surface NN cord-323404-3mw4q7m3 347 91 of of IN cord-323404-3mw4q7m3 347 92 polarized polarized JJ cord-323404-3mw4q7m3 347 93 epithelial epithelial JJ cord-323404-3mw4q7m3 347 94 cells cell NNS cord-323404-3mw4q7m3 347 95 reveals reveal VBZ cord-323404-3mw4q7m3 347 96 the the DT cord-323404-3mw4q7m3 347 97 glycocalyx glycocalyx NNP cord-323404-3mw4q7m3 347 98 as as IN cord-323404-3mw4q7m3 347 99 a a DT cord-323404-3mw4q7m3 347 100 barrier barrier NN cord-323404-3mw4q7m3 347 101 to to IN cord-323404-3mw4q7m3 347 102 adenovirus adenovirus NN cord-323404-3mw4q7m3 347 103 - - HYPH cord-323404-3mw4q7m3 347 104 mediated mediate VBN cord-323404-3mw4q7m3 347 105 gene gene NN cord-323404-3mw4q7m3 347 106 transfer transfer NN cord-323404-3mw4q7m3 348 1 Basolateral Basolateral NNP cord-323404-3mw4q7m3 348 2 localization localization NN cord-323404-3mw4q7m3 348 3 of of IN cord-323404-3mw4q7m3 348 4 fiber fiber NN cord-323404-3mw4q7m3 348 5 receptors receptor NNS cord-323404-3mw4q7m3 348 6 limits limit VBZ cord-323404-3mw4q7m3 348 7 adenovirus adenovirus NN cord-323404-3mw4q7m3 348 8 infection infection NN cord-323404-3mw4q7m3 348 9 from from IN cord-323404-3mw4q7m3 348 10 the the DT cord-323404-3mw4q7m3 348 11 apical apical JJ cord-323404-3mw4q7m3 348 12 surface surface NN cord-323404-3mw4q7m3 348 13 of of IN cord-323404-3mw4q7m3 348 14 airway airway NN cord-323404-3mw4q7m3 348 15 epithelia epithelium NNS cord-323404-3mw4q7m3 348 16 Structural structural JJ cord-323404-3mw4q7m3 348 17 studies study NNS cord-323404-3mw4q7m3 348 18 of of IN cord-323404-3mw4q7m3 348 19 two two CD cord-323404-3mw4q7m3 348 20 rhinovirus rhinovirus NN cord-323404-3mw4q7m3 348 21 serotypes serotype NNS cord-323404-3mw4q7m3 348 22 complexed complexe VBN cord-323404-3mw4q7m3 348 23 with with IN cord-323404-3mw4q7m3 348 24 fragments fragment NNS cord-323404-3mw4q7m3 348 25 of of IN cord-323404-3mw4q7m3 348 26 their -PRON- PRP$ cord-323404-3mw4q7m3 348 27 cellular cellular JJ cord-323404-3mw4q7m3 348 28 receptor receptor NN cord-323404-3mw4q7m3 348 29 Inhibition inhibition NN cord-323404-3mw4q7m3 348 30 of of IN cord-323404-3mw4q7m3 348 31 clathrin clathrin NN cord-323404-3mw4q7m3 348 32 - - HYPH cord-323404-3mw4q7m3 348 33 dependent dependent JJ cord-323404-3mw4q7m3 348 34 endocytosis endocytosis NN cord-323404-3mw4q7m3 348 35 has have VBZ cord-323404-3mw4q7m3 348 36 multiple multiple JJ cord-323404-3mw4q7m3 348 37 effects effect NNS cord-323404-3mw4q7m3 348 38 on on IN cord-323404-3mw4q7m3 348 39 human human JJ cord-323404-3mw4q7m3 348 40 rhinovirus rhinovirus NN cord-323404-3mw4q7m3 348 41 serotype serotype NN cord-323404-3mw4q7m3 348 42 2 2 CD cord-323404-3mw4q7m3 348 43 cell cell NN cord-323404-3mw4q7m3 348 44 entry entry NN cord-323404-3mw4q7m3 349 1 A a DT cord-323404-3mw4q7m3 349 2 novel novel JJ cord-323404-3mw4q7m3 349 3 membrane membrane NN cord-323404-3mw4q7m3 349 4 protein protein NN cord-323404-3mw4q7m3 349 5 is be VBZ cord-323404-3mw4q7m3 349 6 a a DT cord-323404-3mw4q7m3 349 7 mouse mouse NN cord-323404-3mw4q7m3 349 8 mammary mammary JJ cord-323404-3mw4q7m3 349 9 tumor tumor NN cord-323404-3mw4q7m3 349 10 virus virus NN cord-323404-3mw4q7m3 349 11 receptor receptor NN cord-323404-3mw4q7m3 349 12 Coronaviruses Coronaviruses NNPS cord-323404-3mw4q7m3 349 13 in in IN cord-323404-3mw4q7m3 349 14 polarized polarized JJ cord-323404-3mw4q7m3 349 15 epithelial epithelial JJ cord-323404-3mw4q7m3 349 16 cells cell NNS cord-323404-3mw4q7m3 349 17 Infection infection NN cord-323404-3mw4q7m3 349 18 of of IN cord-323404-3mw4q7m3 349 19 polarized polarized JJ cord-323404-3mw4q7m3 349 20 epithelial epithelial JJ cord-323404-3mw4q7m3 349 21 cells cell NNS cord-323404-3mw4q7m3 349 22 with with IN cord-323404-3mw4q7m3 349 23 enteric enteric JJ cord-323404-3mw4q7m3 349 24 and and CC cord-323404-3mw4q7m3 349 25 respiratory respiratory JJ cord-323404-3mw4q7m3 349 26 tract tract NN cord-323404-3mw4q7m3 349 27 bovine bovine NN cord-323404-3mw4q7m3 349 28 coronaviruses coronaviruse NNS cord-323404-3mw4q7m3 349 29 and and CC cord-323404-3mw4q7m3 349 30 release release NN cord-323404-3mw4q7m3 349 31 of of IN cord-323404-3mw4q7m3 349 32 virus virus NN cord-323404-3mw4q7m3 349 33 progeny progeny VBP cord-323404-3mw4q7m3 349 34 Mouse Mouse NNP cord-323404-3mw4q7m3 349 35 hepatitis hepatitis NN cord-323404-3mw4q7m3 349 36 virus virus NN cord-323404-3mw4q7m3 350 1 strain strain NN cord-323404-3mw4q7m3 350 2 A59 A59 NNP cord-323404-3mw4q7m3 350 3 is be VBZ cord-323404-3mw4q7m3 350 4 released release VBN cord-323404-3mw4q7m3 350 5 from from IN cord-323404-3mw4q7m3 350 6 opposite opposite JJ cord-323404-3mw4q7m3 350 7 sides side NNS cord-323404-3mw4q7m3 350 8 of of IN cord-323404-3mw4q7m3 350 9 different different JJ cord-323404-3mw4q7m3 350 10 epithelial epithelial JJ cord-323404-3mw4q7m3 350 11 cell cell NN cord-323404-3mw4q7m3 350 12 types type NNS cord-323404-3mw4q7m3 350 13 Antigenic antigenic JJ cord-323404-3mw4q7m3 350 14 and and CC cord-323404-3mw4q7m3 350 15 molecular molecular JJ cord-323404-3mw4q7m3 350 16 analyses analysis NNS cord-323404-3mw4q7m3 350 17 reveal reveal VBP cord-323404-3mw4q7m3 350 18 that that IN cord-323404-3mw4q7m3 350 19 the the DT cord-323404-3mw4q7m3 350 20 equine equine JJ cord-323404-3mw4q7m3 350 21 rotavirus rotavirus NN cord-323404-3mw4q7m3 350 22 strain strain NN cord-323404-3mw4q7m3 350 23 H-1 H-1 NNP cord-323404-3mw4q7m3 350 24 is be VBZ cord-323404-3mw4q7m3 350 25 closely closely RB cord-323404-3mw4q7m3 350 26 related relate VBN cord-323404-3mw4q7m3 350 27 to to IN cord-323404-3mw4q7m3 350 28 porcine porcine JJ cord-323404-3mw4q7m3 350 29 , , , cord-323404-3mw4q7m3 350 30 but but CC cord-323404-3mw4q7m3 350 31 not not RB cord-323404-3mw4q7m3 350 32 equine equine JJ cord-323404-3mw4q7m3 350 33 , , , cord-323404-3mw4q7m3 350 34 rotaviruses rotavirus NNS cord-323404-3mw4q7m3 350 35 : : : cord-323404-3mw4q7m3 350 36 interspecies interspecies NN cord-323404-3mw4q7m3 350 37 transmission transmission NN cord-323404-3mw4q7m3 350 38 from from IN cord-323404-3mw4q7m3 350 39 pigs pig NNS cord-323404-3mw4q7m3 350 40 to to IN cord-323404-3mw4q7m3 350 41 horses horse NNS cord-323404-3mw4q7m3 350 42 ? ? . cord-323404-3mw4q7m3 351 1 We -PRON- PRP cord-323404-3mw4q7m3 351 2 apologize apologize VBP cord-323404-3mw4q7m3 351 3 to to IN cord-323404-3mw4q7m3 351 4 our -PRON- PRP$ cord-323404-3mw4q7m3 351 5 colleagues colleague NNS cord-323404-3mw4q7m3 351 6 for for IN cord-323404-3mw4q7m3 351 7 omitting omit VBG cord-323404-3mw4q7m3 351 8 references reference NNS cord-323404-3mw4q7m3 351 9 in in IN cord-323404-3mw4q7m3 351 10 this this DT cord-323404-3mw4q7m3 351 11 review review NN cord-323404-3mw4q7m3 351 12 because because IN cord-323404-3mw4q7m3 351 13 of of IN cord-323404-3mw4q7m3 351 14 space space NN cord-323404-3mw4q7m3 351 15 limitations limitation NNS cord-323404-3mw4q7m3 351 16 . . . cord-323404-3mw4q7m3 352 1 We -PRON- PRP cord-323404-3mw4q7m3 352 2 thank thank VBP cord-323404-3mw4q7m3 352 3 B. B. NNP cord-323404-3mw4q7m3 352 4 Wecksler Wecksler NNP cord-323404-3mw4q7m3 352 5 and and CC cord-323404-3mw4q7m3 352 6 V. V. NNP cord-323404-3mw4q7m3 352 7 David David NNP cord-323404-3mw4q7m3 352 8 for for IN cord-323404-3mw4q7m3 352 9 their -PRON- PRP$ cord-323404-3mw4q7m3 352 10 editing editing NN cord-323404-3mw4q7m3 352 11 of of IN cord-323404-3mw4q7m3 352 12 this this DT cord-323404-3mw4q7m3 352 13 manuscript manuscript NN cord-323404-3mw4q7m3 352 14 . . . cord-323404-3mw4q7m3 353 1 This this DT cord-323404-3mw4q7m3 353 2 work work NN cord-323404-3mw4q7m3 353 3 was be VBD cord-323404-3mw4q7m3 353 4 supported support VBN cord-323404-3mw4q7m3 353 5 by by IN cord-323404-3mw4q7m3 353 6 Agence Agence NNP cord-323404-3mw4q7m3 353 7 Nationale Nationale NNP cord-323404-3mw4q7m3 353 8 de de FW cord-323404-3mw4q7m3 353 9 Recherche recherche FW cord-323404-3mw4q7m3 353 10 sur sur FW cord-323404-3mw4q7m3 353 11 le le FW cord-323404-3mw4q7m3 353 12 Sida Sida NNP cord-323404-3mw4q7m3 353 13 ( ( -LRB- cord-323404-3mw4q7m3 353 14 ANRS ANRS NNP cord-323404-3mw4q7m3 353 15 ) ) -RRB- cord-323404-3mw4q7m3 353 16 and and CC cord-323404-3mw4q7m3 353 17 SIDAC SIDAC NNP cord-323404-3mw4q7m3 353 18 - - HYPH cord-323404-3mw4q7m3 353 19 TION TION NNP cord-323404-3mw4q7m3 353 20 / / SYM cord-323404-3mw4q7m3 353 21 Ensemble ensemble NN cord-323404-3mw4q7m3 353 22 Contre Contre NNP cord-323404-3mw4q7m3 353 23 le le FW cord-323404-3mw4q7m3 353 24 SIDA SIDA NNP cord-323404-3mw4q7m3 353 25 funds fund NNS cord-323404-3mw4q7m3 353 26 to to IN cord-323404-3mw4q7m3 353 27 M.B. M.B. NNP cord-323404-3mw4q7m3 354 1 The the DT cord-323404-3mw4q7m3 354 2 following follow VBG cord-323404-3mw4q7m3 354 3 terms term NNS cord-323404-3mw4q7m3 354 4 in in IN cord-323404-3mw4q7m3 354 5 this this DT cord-323404-3mw4q7m3 354 6 article article NN cord-323404-3mw4q7m3 354 7 are be VBP cord-323404-3mw4q7m3 354 8 linked link VBN cord-323404-3mw4q7m3 354 9 online online RB cord-323404-3mw4q7m3 354 10 to to IN cord-323404-3mw4q7m3 354 11 : : : cord-323404-3mw4q7m3 355 1 Entrez Entrez NNP cord-323404-3mw4q7m3 355 2 : : : cord-323404-3mw4q7m3 355 3 http://www.ncbi.nlm.nih.gov/Entrez/ http://www.ncbi.nlm.nih.gov/entrez/ ADD cord-323404-3mw4q7m3 355 4 haemagglutinin haemagglutinin NNP cord-323404-3mw4q7m3 355 5 | | NNP cord-323404-3mw4q7m3 355 6 neuraminidase neuraminidase NN cord-323404-3mw4q7m3 355 7 | | : cord-323404-3mw4q7m3 355 8 gB gB NNP cord-323404-3mw4q7m3 355 9 | | NNP cord-323404-3mw4q7m3 355 10 gC gC NNP cord-323404-3mw4q7m3 356 1 | | NNP cord-323404-3mw4q7m3 356 2 gD gD NNP cord-323404-3mw4q7m3 356 3 | | . cord-323404-3mw4q7m3 357 1 gH gH NNP cord-323404-3mw4q7m3 357 2 | | NNP cord-323404-3mw4q7m3 357 3 gL gL NNP cord-323404-3mw4q7m3 358 1 Swiss Swiss NNP cord-323404-3mw4q7m3 358 2 - - HYPH cord-323404-3mw4q7m3 358 3 Prot Prot NNP cord-323404-3mw4q7m3 358 4 : : : cord-323404-3mw4q7m3 359 1 http://www.expasy.ch/ http://www.expasy.ch/ NNP cord-323404-3mw4q7m3 359 2 CAR CAR NNP cord-323404-3mw4q7m3 359 3 | | HYPH cord-323404-3mw4q7m3 359 4 caveolin caveolin NNP cord-323404-3mw4q7m3 359 5 1 1 CD cord-323404-3mw4q7m3 359 6 | | NNS cord-323404-3mw4q7m3 360 1 CD13 CD13 NNP cord-323404-3mw4q7m3 360 2 | | NNP cord-323404-3mw4q7m3 360 3 CD46 CD46 NNP cord-323404-3mw4q7m3 360 4 | | NNP cord-323404-3mw4q7m3 360 5 DAF DAF NNP cord-323404-3mw4q7m3 360 6 | | NNP cord-323404-3mw4q7m3 360 7 ICAM1 ICAM1 NNP cord-323404-3mw4q7m3 360 8 | | NNP cord-323404-3mw4q7m3 360 9 integrin integrin NN cord-323404-3mw4q7m3 360 10 - - HYPH cord-323404-3mw4q7m3 360 11 α α NN cord-323404-3mw4q7m3 360 12 v v NN cord-323404-3mw4q7m3 360 13 | | NNP cord-323404-3mw4q7m3 360 14 integrin integrin NN cord-323404-3mw4q7m3 360 15 - - HYPH cord-323404-3mw4q7m3 360 16 β6 β6 NNP cord-323404-3mw4q7m3 360 17 | | NNP cord-323404-3mw4q7m3 360 18 JAM JAM NNP cord-323404-3mw4q7m3 360 19 | | NNP cord-323404-3mw4q7m3 360 20 moesin moesin NNP cord-323404-3mw4q7m3 360 21 | | NNP cord-323404-3mw4q7m3 360 22 nectin nectin NNP cord-323404-3mw4q7m3 360 23 1 1 CD cord-323404-3mw4q7m3 360 24 Access Access NNP cord-323404-3mw4q7m3 360 25 to to IN cord-323404-3mw4q7m3 360 26 this this DT cord-323404-3mw4q7m3 360 27 interactive interactive JJ cord-323404-3mw4q7m3 360 28 links link NNS cord-323404-3mw4q7m3 360 29 box box NN cord-323404-3mw4q7m3 360 30 is be VBZ cord-323404-3mw4q7m3 360 31 free free JJ cord-323404-3mw4q7m3 360 32 online online RB cord-323404-3mw4q7m3 360 33 . . .