id	sid	tid	token	lemma	pos
cord-306921-3afgpunj	1	1	key	key	JJ
cord-306921-3afgpunj	1	2	:	:	:
cord-306921-3afgpunj	1	3	cord-306921	cord-306921	NNS
cord-306921-3afgpunj	1	4	-	-	HYPH
cord-306921-3afgpunj	1	5	3afgpunj	3afgpunj	CD
cord-306921-3afgpunj	1	6	authors	author	NNS
cord-306921-3afgpunj	1	7	:	:	:
cord-306921-3afgpunj	1	8	Owino	Owino	NNP
cord-306921-3afgpunj	1	9	,	,	,
cord-306921-3afgpunj	1	10	Collins	Collins	NNP
cord-306921-3afgpunj	1	11	Oduor	Oduor	NNP
cord-306921-3afgpunj	2	1	;	;	:
cord-306921-3afgpunj	2	2	Chu	Chu	NNP
cord-306921-3afgpunj	2	3	,	,	,
cord-306921-3afgpunj	2	4	Justin	Justin	NNP
cord-306921-3afgpunj	2	5	Jang	Jang	NNP
cord-306921-3afgpunj	2	6	Hann	Hann	NNP
cord-306921-3afgpunj	2	7	title	title	NN
cord-306921-3afgpunj	2	8	:	:	:
cord-306921-3afgpunj	3	1	Recent	recent	JJ
cord-306921-3afgpunj	3	2	advances	advance	NNS
cord-306921-3afgpunj	3	3	on	on	IN
cord-306921-3afgpunj	3	4	the	the	DT
cord-306921-3afgpunj	3	5	role	role	NN
cord-306921-3afgpunj	3	6	of	of	IN
cord-306921-3afgpunj	3	7	host	host	NN
cord-306921-3afgpunj	3	8	factors	factor	NNS
cord-306921-3afgpunj	3	9	during	during	IN
cord-306921-3afgpunj	3	10	non	non	JJ
cord-306921-3afgpunj	3	11	-	-	JJ
cord-306921-3afgpunj	3	12	poliovirus	poliovirus	JJ
cord-306921-3afgpunj	3	13	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	3	14	infections	infection	NNS
cord-306921-3afgpunj	3	15	date	date	NN
cord-306921-3afgpunj	3	16	:	:	:
cord-306921-3afgpunj	3	17	2019	2019	CD
cord-306921-3afgpunj	3	18	-	-	HYPH
cord-306921-3afgpunj	3	19	06	06	CD
cord-306921-3afgpunj	3	20	-	-	SYM
cord-306921-3afgpunj	3	21	19	19	CD
cord-306921-3afgpunj	3	22	journal	journal	NN
cord-306921-3afgpunj	3	23	:	:	:
cord-306921-3afgpunj	4	1	J	J	NNP
cord-306921-3afgpunj	4	2	Biomed	Biomed	NNP
cord-306921-3afgpunj	4	3	Sci	Sci	NNP
cord-306921-3afgpunj	4	4	DOI	DOI	NNP
cord-306921-3afgpunj	5	1	:	:	:
cord-306921-3afgpunj	5	2	10.1186	10.1186	CD
cord-306921-3afgpunj	5	3	/	/	SYM
cord-306921-3afgpunj	5	4	s12929	s12929	JJ
cord-306921-3afgpunj	5	5	-	-	HYPH
cord-306921-3afgpunj	5	6	019	019	CD
cord-306921-3afgpunj	5	7	-	-	HYPH
cord-306921-3afgpunj	5	8	0540-y	0540-y	CD
cord-306921-3afgpunj	5	9	sha	sha	NNP
cord-306921-3afgpunj	5	10	:	:	:
cord-306921-3afgpunj	6	1	57ae4e660730c4f3591f27a4058164362d6f5cb4	57ae4e660730c4f3591f27a4058164362d6f5cb4	CD
cord-306921-3afgpunj	6	2	doc_id	doc_id	CD
cord-306921-3afgpunj	6	3	:	:	:
cord-306921-3afgpunj	6	4	306921	306921	CD
cord-306921-3afgpunj	6	5	cord_uid	cord_uid	NNS
cord-306921-3afgpunj	6	6	:	:	:
cord-306921-3afgpunj	7	1	3afgpunj	3afgpunj	CD
cord-306921-3afgpunj	7	2	Non	Non	NNP
cord-306921-3afgpunj	7	3	-	-	JJ
cord-306921-3afgpunj	7	4	polio	polio	JJ
cord-306921-3afgpunj	7	5	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	7	6	are	be	VBP
cord-306921-3afgpunj	7	7	emerging	emerge	VBG
cord-306921-3afgpunj	7	8	viruses	virus	NNS
cord-306921-3afgpunj	7	9	known	know	VBN
cord-306921-3afgpunj	7	10	to	to	TO
cord-306921-3afgpunj	7	11	cause	cause	VB
cord-306921-3afgpunj	7	12	outbreaks	outbreak	NNS
cord-306921-3afgpunj	7	13	of	of	IN
cord-306921-3afgpunj	7	14	polio	polio	NN
cord-306921-3afgpunj	7	15	-	-	HYPH
cord-306921-3afgpunj	7	16	like	like	JJ
cord-306921-3afgpunj	7	17	infections	infection	NNS
cord-306921-3afgpunj	7	18	in	in	IN
cord-306921-3afgpunj	7	19	different	different	JJ
cord-306921-3afgpunj	7	20	parts	part	NNS
cord-306921-3afgpunj	7	21	of	of	IN
cord-306921-3afgpunj	7	22	the	the	DT
cord-306921-3afgpunj	7	23	world	world	NN
cord-306921-3afgpunj	7	24	with	with	IN
cord-306921-3afgpunj	7	25	several	several	JJ
cord-306921-3afgpunj	7	26	cases	case	NNS
cord-306921-3afgpunj	7	27	already	already	RB
cord-306921-3afgpunj	7	28	reported	report	VBN
cord-306921-3afgpunj	7	29	in	in	IN
cord-306921-3afgpunj	7	30	Asia	Asia	NNP
cord-306921-3afgpunj	7	31	Pacific	Pacific	NNP
cord-306921-3afgpunj	7	32	,	,	,
cord-306921-3afgpunj	7	33	Europe	Europe	NNP
cord-306921-3afgpunj	7	34	and	and	CC
cord-306921-3afgpunj	7	35	in	in	IN
cord-306921-3afgpunj	7	36	United	United	NNP
cord-306921-3afgpunj	7	37	States	States	NNP
cord-306921-3afgpunj	7	38	of	of	IN
cord-306921-3afgpunj	7	39	America	America	NNP
cord-306921-3afgpunj	7	40	.	.	.
cord-306921-3afgpunj	8	1	These	these	DT
cord-306921-3afgpunj	8	2	outbreaks	outbreak	NNS
cord-306921-3afgpunj	8	3	normally	normally	RB
cord-306921-3afgpunj	8	4	result	result	VBP
cord-306921-3afgpunj	8	5	in	in	IN
cord-306921-3afgpunj	8	6	overstretching	overstretching	NN
cord-306921-3afgpunj	8	7	of	of	IN
cord-306921-3afgpunj	8	8	health	health	NN
cord-306921-3afgpunj	8	9	facilities	facility	NNS
cord-306921-3afgpunj	8	10	as	as	RB
cord-306921-3afgpunj	8	11	well	well	RB
cord-306921-3afgpunj	8	12	as	as	IN
cord-306921-3afgpunj	8	13	death	death	NN
cord-306921-3afgpunj	8	14	in	in	IN
cord-306921-3afgpunj	8	15	children	child	NNS
cord-306921-3afgpunj	8	16	under	under	IN
cord-306921-3afgpunj	8	17	the	the	DT
cord-306921-3afgpunj	8	18	age	age	NN
cord-306921-3afgpunj	8	19	of	of	IN
cord-306921-3afgpunj	8	20	five	five	CD
cord-306921-3afgpunj	8	21	.	.	.
cord-306921-3afgpunj	9	1	Most	Most	JJS
cord-306921-3afgpunj	9	2	of	of	IN
cord-306921-3afgpunj	9	3	these	these	DT
cord-306921-3afgpunj	9	4	infections	infection	NNS
cord-306921-3afgpunj	9	5	are	be	VBP
cord-306921-3afgpunj	9	6	usually	usually	RB
cord-306921-3afgpunj	9	7	self	self	NN
cord-306921-3afgpunj	9	8	-	-	HYPH
cord-306921-3afgpunj	9	9	limiting	limit	VBG
cord-306921-3afgpunj	9	10	except	except	IN
cord-306921-3afgpunj	9	11	for	for	IN
cord-306921-3afgpunj	9	12	the	the	DT
cord-306921-3afgpunj	9	13	neurological	neurological	JJ
cord-306921-3afgpunj	9	14	complications	complication	NNS
cord-306921-3afgpunj	9	15	associated	associate	VBN
cord-306921-3afgpunj	9	16	with	with	IN
cord-306921-3afgpunj	9	17	human	human	JJ
cord-306921-3afgpunj	9	18	enterovirus	enterovirus	NN
cord-306921-3afgpunj	9	19	A	A	NNP
cord-306921-3afgpunj	9	20	71	71	CD
cord-306921-3afgpunj	9	21	(	(	-LRB-
cord-306921-3afgpunj	9	22	EV	EV	NNP
cord-306921-3afgpunj	9	23	-	-	HYPH
cord-306921-3afgpunj	9	24	A71	A71	NNP
cord-306921-3afgpunj	9	25	)	)	-RRB-
cord-306921-3afgpunj	9	26	.	.	.
cord-306921-3afgpunj	10	1	The	the	DT
cord-306921-3afgpunj	10	2	infection	infection	NN
cord-306921-3afgpunj	10	3	dynamics	dynamic	NNS
cord-306921-3afgpunj	10	4	of	of	IN
cord-306921-3afgpunj	10	5	these	these	DT
cord-306921-3afgpunj	10	6	viruses	virus	NNS
cord-306921-3afgpunj	10	7	have	have	VBP
cord-306921-3afgpunj	10	8	not	not	RB
cord-306921-3afgpunj	10	9	been	be	VBN
cord-306921-3afgpunj	10	10	fully	fully	RB
cord-306921-3afgpunj	10	11	understood	understand	VBN
cord-306921-3afgpunj	10	12	,	,	,
cord-306921-3afgpunj	10	13	with	with	IN
cord-306921-3afgpunj	10	14	most	most	JJS
cord-306921-3afgpunj	10	15	inferences	inference	NNS
cord-306921-3afgpunj	10	16	made	make	VBN
cord-306921-3afgpunj	10	17	from	from	IN
cord-306921-3afgpunj	10	18	previous	previous	JJ
cord-306921-3afgpunj	10	19	studies	study	NNS
cord-306921-3afgpunj	10	20	conducted	conduct	VBN
cord-306921-3afgpunj	10	21	with	with	IN
cord-306921-3afgpunj	10	22	poliovirus	poliovirus	NN
cord-306921-3afgpunj	10	23	.	.	.
cord-306921-3afgpunj	11	1	Non	non	JJ
cord-306921-3afgpunj	11	2	-	-	JJ
cord-306921-3afgpunj	11	3	poliovirus	poliovirus	JJ
cord-306921-3afgpunj	11	4	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	11	5	infections	infection	NNS
cord-306921-3afgpunj	11	6	are	be	VBP
cord-306921-3afgpunj	11	7	responsible	responsible	JJ
cord-306921-3afgpunj	11	8	for	for	IN
cord-306921-3afgpunj	11	9	major	major	JJ
cord-306921-3afgpunj	11	10	outbreaks	outbreak	NNS
cord-306921-3afgpunj	11	11	of	of	IN
cord-306921-3afgpunj	11	12	hand	hand	NN
cord-306921-3afgpunj	11	13	,	,	,
cord-306921-3afgpunj	11	14	foot	foot	NN
cord-306921-3afgpunj	11	15	and	and	CC
cord-306921-3afgpunj	11	16	mouth	mouth	NN
cord-306921-3afgpunj	11	17	disease	disease	NN
cord-306921-3afgpunj	11	18	(	(	-LRB-
cord-306921-3afgpunj	11	19	HFMD	HFMD	NNP
cord-306921-3afgpunj	11	20	)	)	-RRB-
cord-306921-3afgpunj	11	21	often	often	RB
cord-306921-3afgpunj	11	22	associated	associate	VBN
cord-306921-3afgpunj	11	23	with	with	IN
cord-306921-3afgpunj	11	24	neurological	neurological	JJ
cord-306921-3afgpunj	11	25	complications	complication	NNS
cord-306921-3afgpunj	11	26	and	and	CC
cord-306921-3afgpunj	11	27	severe	severe	JJ
cord-306921-3afgpunj	11	28	respiratory	respiratory	JJ
cord-306921-3afgpunj	11	29	diseases	disease	NNS
cord-306921-3afgpunj	11	30	.	.	.
cord-306921-3afgpunj	12	1	The	the	DT
cord-306921-3afgpunj	12	2	myriad	myriad	NNS
cord-306921-3afgpunj	12	3	of	of	IN
cord-306921-3afgpunj	12	4	disease	disease	NN
cord-306921-3afgpunj	12	5	presentations	presentation	NNS
cord-306921-3afgpunj	12	6	observed	observe	VBN
cord-306921-3afgpunj	12	7	so	so	RB
cord-306921-3afgpunj	12	8	far	far	RB
cord-306921-3afgpunj	12	9	in	in	IN
cord-306921-3afgpunj	12	10	children	child	NNS
cord-306921-3afgpunj	12	11	calls	call	VBZ
cord-306921-3afgpunj	12	12	for	for	IN
cord-306921-3afgpunj	12	13	an	an	DT
cord-306921-3afgpunj	12	14	urgent	urgent	JJ
cord-306921-3afgpunj	12	15	need	need	NN
cord-306921-3afgpunj	12	16	to	to	TO
cord-306921-3afgpunj	12	17	fully	fully	RB
cord-306921-3afgpunj	12	18	elucidate	elucidate	VB
cord-306921-3afgpunj	12	19	the	the	DT
cord-306921-3afgpunj	12	20	replication	replication	NN
cord-306921-3afgpunj	12	21	processes	process	NNS
cord-306921-3afgpunj	12	22	of	of	IN
cord-306921-3afgpunj	12	23	these	these	DT
cord-306921-3afgpunj	12	24	viruses	virus	NNS
cord-306921-3afgpunj	12	25	.	.	.
cord-306921-3afgpunj	13	1	There	there	EX
cord-306921-3afgpunj	13	2	are	be	VBP
cord-306921-3afgpunj	13	3	concerted	concerted	JJ
cord-306921-3afgpunj	13	4	efforts	effort	NNS
cord-306921-3afgpunj	13	5	from	from	IN
cord-306921-3afgpunj	13	6	different	different	JJ
cord-306921-3afgpunj	13	7	research	research	NN
cord-306921-3afgpunj	13	8	groups	group	NNS
cord-306921-3afgpunj	13	9	to	to	TO
cord-306921-3afgpunj	13	10	fully	fully	RB
cord-306921-3afgpunj	13	11	map	map	VB
cord-306921-3afgpunj	13	12	out	out	RP
cord-306921-3afgpunj	13	13	the	the	DT
cord-306921-3afgpunj	13	14	role	role	NN
cord-306921-3afgpunj	13	15	of	of	IN
cord-306921-3afgpunj	13	16	human	human	JJ
cord-306921-3afgpunj	13	17	host	host	NN
cord-306921-3afgpunj	13	18	factors	factor	NNS
cord-306921-3afgpunj	13	19	in	in	IN
cord-306921-3afgpunj	13	20	the	the	DT
cord-306921-3afgpunj	13	21	replication	replication	NN
cord-306921-3afgpunj	13	22	cycle	cycle	NN
cord-306921-3afgpunj	13	23	of	of	IN
cord-306921-3afgpunj	13	24	these	these	DT
cord-306921-3afgpunj	13	25	viral	viral	JJ
cord-306921-3afgpunj	13	26	infections	infection	NNS
cord-306921-3afgpunj	13	27	.	.	.
cord-306921-3afgpunj	14	1	Understanding	understand	VBG
cord-306921-3afgpunj	14	2	the	the	DT
cord-306921-3afgpunj	14	3	interaction	interaction	NN
cord-306921-3afgpunj	14	4	between	between	IN
cord-306921-3afgpunj	14	5	viral	viral	JJ
cord-306921-3afgpunj	14	6	proteins	protein	NNS
cord-306921-3afgpunj	14	7	and	and	CC
cord-306921-3afgpunj	14	8	human	human	JJ
cord-306921-3afgpunj	14	9	host	host	NN
cord-306921-3afgpunj	14	10	factors	factor	NNS
cord-306921-3afgpunj	14	11	will	will	MD
cord-306921-3afgpunj	14	12	unravel	unravel	VB
cord-306921-3afgpunj	14	13	important	important	JJ
cord-306921-3afgpunj	14	14	insights	insight	NNS
cord-306921-3afgpunj	14	15	on	on	IN
cord-306921-3afgpunj	14	16	the	the	DT
cord-306921-3afgpunj	14	17	lifecycle	lifecycle	NN
cord-306921-3afgpunj	14	18	of	of	IN
cord-306921-3afgpunj	14	19	this	this	DT
cord-306921-3afgpunj	14	20	groups	group	NNS
cord-306921-3afgpunj	14	21	of	of	IN
cord-306921-3afgpunj	14	22	viruses	virus	NNS
cord-306921-3afgpunj	14	23	.	.	.
cord-306921-3afgpunj	15	1	This	this	DT
cord-306921-3afgpunj	15	2	review	review	NN
cord-306921-3afgpunj	15	3	provides	provide	VBZ
cord-306921-3afgpunj	15	4	the	the	DT
cord-306921-3afgpunj	15	5	latest	late	JJS
cord-306921-3afgpunj	15	6	update	update	NN
cord-306921-3afgpunj	15	7	on	on	IN
cord-306921-3afgpunj	15	8	the	the	DT
cord-306921-3afgpunj	15	9	interplay	interplay	NN
cord-306921-3afgpunj	15	10	between	between	IN
cord-306921-3afgpunj	15	11	human	human	JJ
cord-306921-3afgpunj	15	12	host	host	NN
cord-306921-3afgpunj	15	13	factors	factor	NNS
cord-306921-3afgpunj	15	14	/	/	SYM
cord-306921-3afgpunj	15	15	processes	process	NNS
cord-306921-3afgpunj	15	16	and	and	CC
cord-306921-3afgpunj	15	17	non	non	JJ
cord-306921-3afgpunj	15	18	-	-	JJ
cord-306921-3afgpunj	15	19	polio	polio	JJ
cord-306921-3afgpunj	15	20	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	15	21	(	(	-LRB-
cord-306921-3afgpunj	15	22	NPEV	NPEV	NNP
cord-306921-3afgpunj	15	23	)	)	-RRB-
cord-306921-3afgpunj	15	24	.	.	.
cord-306921-3afgpunj	16	1	We	-PRON-	PRP
cord-306921-3afgpunj	16	2	focus	focus	VBP
cord-306921-3afgpunj	16	3	on	on	IN
cord-306921-3afgpunj	16	4	the	the	DT
cord-306921-3afgpunj	16	5	interactions	interaction	NNS
cord-306921-3afgpunj	16	6	involved	involve	VBN
cord-306921-3afgpunj	16	7	in	in	IN
cord-306921-3afgpunj	16	8	viral	viral	JJ
cord-306921-3afgpunj	16	9	attachment	attachment	NN
cord-306921-3afgpunj	16	10	,	,	,
cord-306921-3afgpunj	16	11	entry	entry	NN
cord-306921-3afgpunj	16	12	,	,	,
cord-306921-3afgpunj	16	13	internalization	internalization	NN
cord-306921-3afgpunj	16	14	,	,	,
cord-306921-3afgpunj	16	15	uncoating	uncoating	NN
cord-306921-3afgpunj	16	16	,	,	,
cord-306921-3afgpunj	16	17	replication	replication	NN
cord-306921-3afgpunj	16	18	,	,	,
cord-306921-3afgpunj	16	19	virion	virion	NN
cord-306921-3afgpunj	16	20	assembly	assembly	NN
cord-306921-3afgpunj	16	21	and	and	CC
cord-306921-3afgpunj	16	22	eventual	eventual	JJ
cord-306921-3afgpunj	16	23	egress	egress	NN
cord-306921-3afgpunj	16	24	of	of	IN
cord-306921-3afgpunj	16	25	the	the	DT
cord-306921-3afgpunj	16	26	NPEV	NPEV	NNP
cord-306921-3afgpunj	16	27	from	from	IN
cord-306921-3afgpunj	16	28	the	the	DT
cord-306921-3afgpunj	16	29	infected	infected	JJ
cord-306921-3afgpunj	16	30	cells	cell	NNS
cord-306921-3afgpunj	16	31	.	.	.
cord-306921-3afgpunj	17	1	We	-PRON-	PRP
cord-306921-3afgpunj	17	2	emphasize	emphasize	VBP
cord-306921-3afgpunj	17	3	on	on	IN
cord-306921-3afgpunj	17	4	the	the	DT
cord-306921-3afgpunj	17	5	virus-	virus-	NNP
cord-306921-3afgpunj	17	6	human	human	JJ
cord-306921-3afgpunj	17	7	host	host	NN
cord-306921-3afgpunj	17	8	interplay	interplay	NN
cord-306921-3afgpunj	17	9	and	and	CC
cord-306921-3afgpunj	17	10	highlight	highlight	VB
cord-306921-3afgpunj	17	11	existing	exist	VBG
cord-306921-3afgpunj	17	12	knowledge	knowledge	NN
cord-306921-3afgpunj	17	13	gaps	gap	NNS
cord-306921-3afgpunj	17	14	that	that	WDT
cord-306921-3afgpunj	17	15	needs	need	VBZ
cord-306921-3afgpunj	17	16	further	further	JJ
cord-306921-3afgpunj	17	17	studies	study	NNS
cord-306921-3afgpunj	17	18	.	.	.
cord-306921-3afgpunj	18	1	Understanding	understand	VBG
cord-306921-3afgpunj	18	2	the	the	DT
cord-306921-3afgpunj	18	3	NPEV	NPEV	NNP
cord-306921-3afgpunj	18	4	-	-	HYPH
cord-306921-3afgpunj	18	5	human	human	JJ
cord-306921-3afgpunj	18	6	host	host	NN
cord-306921-3afgpunj	18	7	factors	factor	NNS
cord-306921-3afgpunj	18	8	interactions	interaction	NNS
cord-306921-3afgpunj	18	9	will	will	MD
cord-306921-3afgpunj	18	10	be	be	VB
cord-306921-3afgpunj	18	11	key	key	JJ
cord-306921-3afgpunj	18	12	in	in	IN
cord-306921-3afgpunj	18	13	the	the	DT
cord-306921-3afgpunj	18	14	design	design	NN
cord-306921-3afgpunj	18	15	and	and	CC
cord-306921-3afgpunj	18	16	development	development	NN
cord-306921-3afgpunj	18	17	of	of	IN
cord-306921-3afgpunj	18	18	vaccines	vaccine	NNS
cord-306921-3afgpunj	18	19	as	as	RB
cord-306921-3afgpunj	18	20	well	well	RB
cord-306921-3afgpunj	18	21	as	as	IN
cord-306921-3afgpunj	18	22	antivirals	antiviral	NNS
cord-306921-3afgpunj	18	23	against	against	IN
cord-306921-3afgpunj	18	24	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	18	25	infections	infection	NNS
cord-306921-3afgpunj	18	26	.	.	.
cord-306921-3afgpunj	19	1	Dissecting	dissect	VBG
cord-306921-3afgpunj	19	2	the	the	DT
cord-306921-3afgpunj	19	3	role	role	NN
cord-306921-3afgpunj	19	4	of	of	IN
cord-306921-3afgpunj	19	5	human	human	JJ
cord-306921-3afgpunj	19	6	host	host	NN
cord-306921-3afgpunj	19	7	factors	factor	NNS
cord-306921-3afgpunj	19	8	during	during	IN
cord-306921-3afgpunj	19	9	NPEV	NPEV	NNP
cord-306921-3afgpunj	19	10	infection	infection	NN
cord-306921-3afgpunj	19	11	cycle	cycle	NN
cord-306921-3afgpunj	19	12	will	will	MD
cord-306921-3afgpunj	19	13	provide	provide	VB
cord-306921-3afgpunj	19	14	a	a	DT
cord-306921-3afgpunj	19	15	clear	clear	JJ
cord-306921-3afgpunj	19	16	picture	picture	NN
cord-306921-3afgpunj	19	17	of	of	IN
cord-306921-3afgpunj	19	18	how	how	WRB
cord-306921-3afgpunj	19	19	NPEVs	npev	NNS
cord-306921-3afgpunj	19	20	usurp	usurp	VBP
cord-306921-3afgpunj	19	21	the	the	DT
cord-306921-3afgpunj	19	22	human	human	JJ
cord-306921-3afgpunj	19	23	cellular	cellular	JJ
cord-306921-3afgpunj	19	24	processes	process	NNS
cord-306921-3afgpunj	19	25	to	to	TO
cord-306921-3afgpunj	19	26	establish	establish	VB
cord-306921-3afgpunj	19	27	an	an	DT
cord-306921-3afgpunj	19	28	efficient	efficient	JJ
cord-306921-3afgpunj	19	29	infection	infection	NN
cord-306921-3afgpunj	19	30	.	.	.
cord-306921-3afgpunj	20	1	This	this	DT
cord-306921-3afgpunj	20	2	will	will	MD
cord-306921-3afgpunj	20	3	be	be	VB
cord-306921-3afgpunj	20	4	a	a	DT
cord-306921-3afgpunj	20	5	boost	boost	NN
cord-306921-3afgpunj	20	6	to	to	IN
cord-306921-3afgpunj	20	7	the	the	DT
cord-306921-3afgpunj	20	8	drug	drug	NN
cord-306921-3afgpunj	20	9	and	and	CC
cord-306921-3afgpunj	20	10	vaccine	vaccine	NN
cord-306921-3afgpunj	20	11	development	development	NN
cord-306921-3afgpunj	20	12	against	against	IN
cord-306921-3afgpunj	20	13	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	20	14	which	which	WDT
cord-306921-3afgpunj	20	15	will	will	MD
cord-306921-3afgpunj	20	16	be	be	VB
cord-306921-3afgpunj	20	17	key	key	JJ
cord-306921-3afgpunj	20	18	in	in	IN
cord-306921-3afgpunj	20	19	control	control	NN
cord-306921-3afgpunj	20	20	and	and	CC
cord-306921-3afgpunj	20	21	eventual	eventual	JJ
cord-306921-3afgpunj	20	22	elimination	elimination	NN
cord-306921-3afgpunj	20	23	of	of	IN
cord-306921-3afgpunj	20	24	the	the	DT
cord-306921-3afgpunj	20	25	viral	viral	JJ
cord-306921-3afgpunj	20	26	infections	infection	NNS
cord-306921-3afgpunj	20	27	.	.	.
cord-306921-3afgpunj	21	1	Non	Non	NNP
cord-306921-3afgpunj	21	2	-	-	JJ
cord-306921-3afgpunj	21	3	Polio	Polio	NNP
cord-306921-3afgpunj	21	4	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	21	5	belong	belong	VBP
cord-306921-3afgpunj	21	6	to	to	IN
cord-306921-3afgpunj	21	7	the	the	DT
cord-306921-3afgpunj	21	8	genus	genus	NN
cord-306921-3afgpunj	21	9	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	21	10	(	(	-LRB-
cord-306921-3afgpunj	21	11	consisting	consist	VBG
cord-306921-3afgpunj	21	12	of	of	IN
cord-306921-3afgpunj	21	13	15	15	CD
cord-306921-3afgpunj	21	14	species	specie	NNS
cord-306921-3afgpunj	21	15	)	)	-RRB-
cord-306921-3afgpunj	21	16	;	;	:
cord-306921-3afgpunj	21	17	family	family	NN
cord-306921-3afgpunj	21	18	Picornaviridae	Picornaviridae	NNP
cord-306921-3afgpunj	21	19	[	[	-LRB-
cord-306921-3afgpunj	21	20	1	1	CD
cord-306921-3afgpunj	21	21	]	]	-RRB-
cord-306921-3afgpunj	21	22	and	and	CC
cord-306921-3afgpunj	21	23	have	have	VBP
cord-306921-3afgpunj	21	24	been	be	VBN
cord-306921-3afgpunj	21	25	identified	identify	VBN
cord-306921-3afgpunj	21	26	in	in	IN
cord-306921-3afgpunj	21	27	different	different	JJ
cord-306921-3afgpunj	21	28	parts	part	NNS
cord-306921-3afgpunj	21	29	of	of	IN
cord-306921-3afgpunj	21	30	the	the	DT
cord-306921-3afgpunj	21	31	world	world	NN
cord-306921-3afgpunj	21	32	affecting	affect	VBG
cord-306921-3afgpunj	21	33	human	human	JJ
cord-306921-3afgpunj	21	34	population	population	NN
cord-306921-3afgpunj	21	35	[	[	-LRB-
cord-306921-3afgpunj	21	36	2	2	CD
cord-306921-3afgpunj	21	37	]	]	-RRB-
cord-306921-3afgpunj	21	38	.	.	.
cord-306921-3afgpunj	22	1	Major	major	JJ
cord-306921-3afgpunj	22	2	outbreaks	outbreak	NNS
cord-306921-3afgpunj	22	3	of	of	IN
cord-306921-3afgpunj	22	4	nonpolio	nonpolio	NNP
cord-306921-3afgpunj	22	5	virus	virus	NN
cord-306921-3afgpunj	22	6	associated	associate	VBD
cord-306921-3afgpunj	22	7	infections	infection	NNS
cord-306921-3afgpunj	22	8	have	have	VBP
cord-306921-3afgpunj	22	9	been	be	VBN
cord-306921-3afgpunj	22	10	recently	recently	RB
cord-306921-3afgpunj	22	11	reported	report	VBN
cord-306921-3afgpunj	22	12	in	in	IN
cord-306921-3afgpunj	22	13	Asia	Asia	NNP
cord-306921-3afgpunj	22	14	Pacific	Pacific	NNP
cord-306921-3afgpunj	22	15	,	,	,
cord-306921-3afgpunj	22	16	Europe	Europe	NNP
cord-306921-3afgpunj	22	17	,	,	,
cord-306921-3afgpunj	22	18	Canada	Canada	NNP
cord-306921-3afgpunj	22	19	and	and	CC
cord-306921-3afgpunj	22	20	United	United	NNP
cord-306921-3afgpunj	22	21	States	States	NNP
cord-306921-3afgpunj	22	22	of	of	IN
cord-306921-3afgpunj	22	23	America	America	NNP
cord-306921-3afgpunj	22	24	(	(	-LRB-
cord-306921-3afgpunj	22	25	USA	USA	NNP
cord-306921-3afgpunj	22	26	)	)	-RRB-
cord-306921-3afgpunj	22	27	.	.	.
cord-306921-3afgpunj	23	1	The	the	DT
cord-306921-3afgpunj	23	2	peak	peak	NN
cord-306921-3afgpunj	23	3	of	of	IN
cord-306921-3afgpunj	23	4	these	these	DT
cord-306921-3afgpunj	23	5	infections	infection	NNS
cord-306921-3afgpunj	23	6	is	be	VBZ
cord-306921-3afgpunj	23	7	coming	come	VBG
cord-306921-3afgpunj	23	8	at	at	IN
cord-306921-3afgpunj	23	9	a	a	DT
cord-306921-3afgpunj	23	10	time	time	NN
cord-306921-3afgpunj	23	11	when	when	WRB
cord-306921-3afgpunj	23	12	the	the	DT
cord-306921-3afgpunj	23	13	world	world	NN
cord-306921-3afgpunj	23	14	is	be	VBZ
cord-306921-3afgpunj	23	15	nearing	near	VBG
cord-306921-3afgpunj	23	16	eradication	eradication	NN
cord-306921-3afgpunj	23	17	of	of	IN
cord-306921-3afgpunj	23	18	poliomyelitis	poliomyelitis	NN
cord-306921-3afgpunj	23	19	,	,	,
cord-306921-3afgpunj	23	20	with	with	IN
cord-306921-3afgpunj	23	21	just	just	RB
cord-306921-3afgpunj	23	22	small	small	JJ
cord-306921-3afgpunj	23	23	number	number	NN
cord-306921-3afgpunj	23	24	of	of	IN
cord-306921-3afgpunj	23	25	cases	case	NNS
cord-306921-3afgpunj	23	26	reported	report	VBN
cord-306921-3afgpunj	23	27	in	in	IN
cord-306921-3afgpunj	23	28	some	some	DT
cord-306921-3afgpunj	23	29	parts	part	NNS
cord-306921-3afgpunj	23	30	of	of	IN
cord-306921-3afgpunj	23	31	the	the	DT
cord-306921-3afgpunj	23	32	world	world	NN
cord-306921-3afgpunj	23	33	[	[	-LRB-
cord-306921-3afgpunj	23	34	3	3	CD
cord-306921-3afgpunj	23	35	]	]	-RRB-
cord-306921-3afgpunj	23	36	.	.	.
cord-306921-3afgpunj	24	1	The	the	DT
cord-306921-3afgpunj	24	2	burden	burden	NN
cord-306921-3afgpunj	24	3	of	of	IN
cord-306921-3afgpunj	24	4	these	these	DT
cord-306921-3afgpunj	24	5	infections	infection	NNS
cord-306921-3afgpunj	24	6	has	have	VBZ
cord-306921-3afgpunj	24	7	been	be	VBN
cord-306921-3afgpunj	24	8	felt	feel	VBN
cord-306921-3afgpunj	24	9	in	in	IN
cord-306921-3afgpunj	24	10	children	child	NNS
cord-306921-3afgpunj	24	11	under	under	IN
cord-306921-3afgpunj	24	12	the	the	DT
cord-306921-3afgpunj	24	13	age	age	NN
cord-306921-3afgpunj	24	14	of	of	IN
cord-306921-3afgpunj	24	15	five	five	CD
cord-306921-3afgpunj	24	16	;	;	:
cord-306921-3afgpunj	24	17	most	most	JJS
cord-306921-3afgpunj	24	18	of	of	IN
cord-306921-3afgpunj	24	19	whom	whom	WP
cord-306921-3afgpunj	24	20	are	be	VBP
cord-306921-3afgpunj	24	21	just	just	RB
cord-306921-3afgpunj	24	22	beginning	begin	VBG
cord-306921-3afgpunj	24	23	their	-PRON-	PRP$
cord-306921-3afgpunj	24	24	early	early	JJ
cord-306921-3afgpunj	24	25	years	year	NNS
cord-306921-3afgpunj	24	26	at	at	IN
cord-306921-3afgpunj	24	27	school	school	NN
cord-306921-3afgpunj	24	28	.	.	.
cord-306921-3afgpunj	25	1	Most	Most	JJS
cord-306921-3afgpunj	25	2	of	of	IN
cord-306921-3afgpunj	25	3	these	these	DT
cord-306921-3afgpunj	25	4	infections	infection	NNS
cord-306921-3afgpunj	25	5	are	be	VBP
cord-306921-3afgpunj	25	6	known	know	VBN
cord-306921-3afgpunj	25	7	to	to	TO
cord-306921-3afgpunj	25	8	be	be	VB
cord-306921-3afgpunj	25	9	selflimiting	selflimite	VBG
cord-306921-3afgpunj	25	10	but	but	CC
cord-306921-3afgpunj	25	11	severe	severe	JJ
cord-306921-3afgpunj	25	12	neurological	neurological	JJ
cord-306921-3afgpunj	25	13	complications	complication	NNS
cord-306921-3afgpunj	25	14	and	and	CC
cord-306921-3afgpunj	25	15	even	even	RB
cord-306921-3afgpunj	25	16	death	death	NN
cord-306921-3afgpunj	25	17	has	have	VBZ
cord-306921-3afgpunj	25	18	been	be	VBN
cord-306921-3afgpunj	25	19	reported	report	VBN
cord-306921-3afgpunj	25	20	in	in	IN
cord-306921-3afgpunj	25	21	some	some	DT
cord-306921-3afgpunj	25	22	cases	case	NNS
cord-306921-3afgpunj	25	23	.	.	.
cord-306921-3afgpunj	26	1	The	the	DT
cord-306921-3afgpunj	26	2	focus	focus	NN
cord-306921-3afgpunj	26	3	of	of	IN
cord-306921-3afgpunj	26	4	this	this	DT
cord-306921-3afgpunj	26	5	review	review	NN
cord-306921-3afgpunj	26	6	is	be	VBZ
cord-306921-3afgpunj	26	7	to	to	TO
cord-306921-3afgpunj	26	8	highlight	highlight	VB
cord-306921-3afgpunj	26	9	the	the	DT
cord-306921-3afgpunj	26	10	known	know	VBN
cord-306921-3afgpunj	26	11	role	role	NN
cord-306921-3afgpunj	26	12	of	of	IN
cord-306921-3afgpunj	26	13	human	human	JJ
cord-306921-3afgpunj	26	14	host	host	NN
cord-306921-3afgpunj	26	15	factors	factor	NNS
cord-306921-3afgpunj	26	16	and	and	CC
cord-306921-3afgpunj	26	17	processes	process	NNS
cord-306921-3afgpunj	26	18	during	during	IN
cord-306921-3afgpunj	26	19	the	the	DT
cord-306921-3afgpunj	26	20	selected	select	VBN
cord-306921-3afgpunj	26	21	NPEV	NPEV	NNP
cord-306921-3afgpunj	26	22	infections	infection	NNS
cord-306921-3afgpunj	26	23	.	.	.
cord-306921-3afgpunj	27	1	A	a	DT
cord-306921-3afgpunj	27	2	brief	brief	JJ
cord-306921-3afgpunj	27	3	introduction	introduction	NN
cord-306921-3afgpunj	27	4	on	on	IN
cord-306921-3afgpunj	27	5	the	the	DT
cord-306921-3afgpunj	27	6	epidemiology	epidemiology	NN
cord-306921-3afgpunj	27	7	and	and	CC
cord-306921-3afgpunj	27	8	pathogenesis	pathogenesis	NN
cord-306921-3afgpunj	27	9	of	of	IN
cord-306921-3afgpunj	27	10	the	the	DT
cord-306921-3afgpunj	27	11	selected	select	VBN
cord-306921-3afgpunj	27	12	non	non	JJ
cord-306921-3afgpunj	27	13	-	-	JJ
cord-306921-3afgpunj	27	14	polio	polio	JJ
cord-306921-3afgpunj	27	15	viruses	virus	NNS
cord-306921-3afgpunj	27	16	are	be	VBP
cord-306921-3afgpunj	27	17	described	describe	VBN
cord-306921-3afgpunj	27	18	.	.	.
cord-306921-3afgpunj	28	1	The	the	DT
cord-306921-3afgpunj	28	2	viral	viral	JJ
cord-306921-3afgpunj	28	3	-	-	HYPH
cord-306921-3afgpunj	28	4	host	host	NN
cord-306921-3afgpunj	28	5	process	process	NN
cord-306921-3afgpunj	28	6	/	/	SYM
cord-306921-3afgpunj	28	7	protein	protein	NN
cord-306921-3afgpunj	28	8	interactions	interaction	NNS
cord-306921-3afgpunj	28	9	are	be	VBP
cord-306921-3afgpunj	28	10	then	then	RB
cord-306921-3afgpunj	28	11	discussed	discuss	VBN
cord-306921-3afgpunj	28	12	,	,	,
cord-306921-3afgpunj	28	13	followed	follow	VBN
cord-306921-3afgpunj	28	14	by	by	IN
cord-306921-3afgpunj	28	15	the	the	DT
cord-306921-3afgpunj	28	16	existing	exist	VBG
cord-306921-3afgpunj	28	17	gaps	gap	NNS
cord-306921-3afgpunj	28	18	that	that	WDT
cord-306921-3afgpunj	28	19	need	need	VBP
cord-306921-3afgpunj	28	20	to	to	TO
cord-306921-3afgpunj	28	21	be	be	VB
cord-306921-3afgpunj	28	22	addressed	address	VBN
cord-306921-3afgpunj	28	23	in	in	IN
cord-306921-3afgpunj	28	24	future	future	NN
cord-306921-3afgpunj	28	25	.	.	.
cord-306921-3afgpunj	29	1	The	the	DT
cord-306921-3afgpunj	29	2	ability	ability	NN
cord-306921-3afgpunj	29	3	of	of	IN
cord-306921-3afgpunj	29	4	various	various	JJ
cord-306921-3afgpunj	29	5	NPEV	NPEV	NNP
cord-306921-3afgpunj	29	6	viruses	virus	NNS
cord-306921-3afgpunj	29	7	to	to	TO
cord-306921-3afgpunj	29	8	usurp	usurp	VB
cord-306921-3afgpunj	29	9	various	various	JJ
cord-306921-3afgpunj	29	10	cellular	cellular	JJ
cord-306921-3afgpunj	29	11	processes	process	NNS
cord-306921-3afgpunj	29	12	such	such	JJ
cord-306921-3afgpunj	29	13	as	as	IN
cord-306921-3afgpunj	29	14	;	;	:
cord-306921-3afgpunj	29	15	cell	cell	NN
cord-306921-3afgpunj	29	16	cycle	cycle	NN
cord-306921-3afgpunj	29	17	division	division	NN
cord-306921-3afgpunj	29	18	,	,	,
cord-306921-3afgpunj	29	19	autophagy	autophagy	NN
cord-306921-3afgpunj	29	20	as	as	RB
cord-306921-3afgpunj	29	21	well	well	RB
cord-306921-3afgpunj	29	22	apoptosis	apoptosis	NN
cord-306921-3afgpunj	29	23	,	,	,
cord-306921-3afgpunj	29	24	necroptosis	necroptosis	NNP
cord-306921-3afgpunj	29	25	and	and	CC
cord-306921-3afgpunj	29	26	pyroptosis	pyroptosis	NNP
cord-306921-3afgpunj	29	27	for	for	IN
cord-306921-3afgpunj	29	28	efficient	efficient	JJ
cord-306921-3afgpunj	29	29	replication	replication	NN
cord-306921-3afgpunj	29	30	are	be	VBP
cord-306921-3afgpunj	29	31	also	also	RB
cord-306921-3afgpunj	29	32	highlighted	highlight	VBN
cord-306921-3afgpunj	29	33	.	.	.
cord-306921-3afgpunj	30	1	The	the	DT
cord-306921-3afgpunj	30	2	state	state	NN
cord-306921-3afgpunj	30	3	of	of	IN
cord-306921-3afgpunj	30	4	antiviral	antiviral	JJ
cord-306921-3afgpunj	30	5	therapy	therapy	NN
cord-306921-3afgpunj	30	6	research	research	NN
cord-306921-3afgpunj	30	7	against	against	IN
cord-306921-3afgpunj	30	8	these	these	DT
cord-306921-3afgpunj	30	9	viruses	virus	NNS
cord-306921-3afgpunj	30	10	is	be	VBZ
cord-306921-3afgpunj	30	11	briefly	briefly	NN
cord-306921-3afgpunj	30	12	discussed	discuss	VBN
cord-306921-3afgpunj	30	13	and	and	CC
cord-306921-3afgpunj	30	14	existing	exist	VBG
cord-306921-3afgpunj	30	15	gaps	gap	NNS
cord-306921-3afgpunj	30	16	highlighted	highlight	VBN
cord-306921-3afgpunj	30	17	.	.	.
cord-306921-3afgpunj	31	1	The	the	DT
cord-306921-3afgpunj	31	2	future	future	JJ
cord-306921-3afgpunj	31	3	perspectives	perspective	NNS
cord-306921-3afgpunj	31	4	and	and	CC
cord-306921-3afgpunj	31	5	areas	area	NNS
cord-306921-3afgpunj	31	6	of	of	IN
cord-306921-3afgpunj	31	7	concern	concern	NN
cord-306921-3afgpunj	31	8	are	be	VBP
cord-306921-3afgpunj	31	9	also	also	RB
cord-306921-3afgpunj	31	10	emphasized	emphasize	VBN
cord-306921-3afgpunj	31	11	.	.	.
cord-306921-3afgpunj	32	1	Enterovirus	enterovirus	NN
cord-306921-3afgpunj	32	2	A	a	DT
cord-306921-3afgpunj	32	3	71	71	CD
cord-306921-3afgpunj	32	4	(	(	-LRB-
cord-306921-3afgpunj	32	5	EV	EV	NNP
cord-306921-3afgpunj	32	6	-	-	HYPH
cord-306921-3afgpunj	32	7	A71	A71	NNP
cord-306921-3afgpunj	32	8	)	)	-RRB-
cord-306921-3afgpunj	32	9	was	be	VBD
cord-306921-3afgpunj	32	10	first	first	RB
cord-306921-3afgpunj	32	11	isolated	isolate	VBN
cord-306921-3afgpunj	32	12	from	from	IN
cord-306921-3afgpunj	32	13	fecal	fecal	JJ
cord-306921-3afgpunj	32	14	and	and	CC
cord-306921-3afgpunj	32	15	throat	throat	NN
cord-306921-3afgpunj	32	16	swab	swab	NN
cord-306921-3afgpunj	32	17	samples	sample	NNS
cord-306921-3afgpunj	32	18	from	from	IN
cord-306921-3afgpunj	32	19	patients	patient	NNS
cord-306921-3afgpunj	32	20	with	with	IN
cord-306921-3afgpunj	32	21	central	central	JJ
cord-306921-3afgpunj	32	22	nervous	nervous	JJ
cord-306921-3afgpunj	32	23	system	system	NN
cord-306921-3afgpunj	32	24	complications	complication	NNS
cord-306921-3afgpunj	32	25	in	in	IN
cord-306921-3afgpunj	32	26	California	California	NNP
cord-306921-3afgpunj	32	27	[	[	-LRB-
cord-306921-3afgpunj	32	28	4	4	CD
cord-306921-3afgpunj	32	29	]	]	-RRB-
cord-306921-3afgpunj	32	30	.	.	.
cord-306921-3afgpunj	33	1	Since	since	IN
cord-306921-3afgpunj	33	2	then	then	RB
cord-306921-3afgpunj	33	3	,	,	,
cord-306921-3afgpunj	33	4	EV	EV	NNP
cord-306921-3afgpunj	33	5	-	-	HYPH
cord-306921-3afgpunj	33	6	A71	A71	NNP
cord-306921-3afgpunj	33	7	has	have	VBZ
cord-306921-3afgpunj	33	8	been	be	VBN
cord-306921-3afgpunj	33	9	linked	link	VBN
cord-306921-3afgpunj	33	10	with	with	IN
cord-306921-3afgpunj	33	11	outbreaks	outbreak	NNS
cord-306921-3afgpunj	33	12	of	of	IN
cord-306921-3afgpunj	33	13	foot	foot	NN
cord-306921-3afgpunj	33	14	,	,	,
cord-306921-3afgpunj	33	15	hand	hand	NN
cord-306921-3afgpunj	33	16	and	and	CC
cord-306921-3afgpunj	33	17	mouth	mouth	NN
cord-306921-3afgpunj	33	18	disease	disease	NN
cord-306921-3afgpunj	33	19	(	(	-LRB-
cord-306921-3afgpunj	33	20	HFMD	HFMD	NNP
cord-306921-3afgpunj	33	21	)	)	-RRB-
cord-306921-3afgpunj	33	22	;	;	:
cord-306921-3afgpunj	33	23	often	often	RB
cord-306921-3afgpunj	33	24	a	a	DT
cord-306921-3afgpunj	33	25	self	self	NN
cord-306921-3afgpunj	33	26	-	-	HYPH
cord-306921-3afgpunj	33	27	limiting	limit	VBG
cord-306921-3afgpunj	33	28	infection	infection	NN
cord-306921-3afgpunj	33	29	characterized	characterize	VBN
cord-306921-3afgpunj	33	30	with	with	IN
cord-306921-3afgpunj	33	31	and	and	CC
cord-306921-3afgpunj	33	32	severe	severe	JJ
cord-306921-3afgpunj	33	33	forms	form	NNS
cord-306921-3afgpunj	33	34	characterized	characterize	VBN
cord-306921-3afgpunj	33	35	with	with	IN
cord-306921-3afgpunj	33	36	acute	acute	JJ
cord-306921-3afgpunj	33	37	flaccid	flaccid	JJ
cord-306921-3afgpunj	33	38	paralysis	paralysis	NN
cord-306921-3afgpunj	33	39	and	and	CC
cord-306921-3afgpunj	33	40	brainstem	brainstem	NN
cord-306921-3afgpunj	33	41	encephalomyelitis	encephalomyelitis	NN
cord-306921-3afgpunj	33	42	[	[	-LRB-
cord-306921-3afgpunj	33	43	5	5	CD
cord-306921-3afgpunj	33	44	]	]	-RRB-
cord-306921-3afgpunj	33	45	[	[	-LRB-
cord-306921-3afgpunj	33	46	6	6	CD
cord-306921-3afgpunj	33	47	]	]	-RRB-
cord-306921-3afgpunj	33	48	[	[	-LRB-
cord-306921-3afgpunj	33	49	7	7	CD
cord-306921-3afgpunj	33	50	]	]	-RRB-
cord-306921-3afgpunj	33	51	[	[	-LRB-
cord-306921-3afgpunj	33	52	8	8	CD
cord-306921-3afgpunj	33	53	]	]	-RRB-
cord-306921-3afgpunj	33	54	.	.	.
cord-306921-3afgpunj	34	1	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	34	2	A16	A16	NNP
cord-306921-3afgpunj	34	3	(	(	-LRB-
cord-306921-3afgpunj	34	4	CV	cv	NN
cord-306921-3afgpunj	34	5	-	-	HYPH
cord-306921-3afgpunj	34	6	A16	A16	NNP
cord-306921-3afgpunj	34	7	)	)	-RRB-
cord-306921-3afgpunj	34	8	,	,	,
cord-306921-3afgpunj	34	9	also	also	RB
cord-306921-3afgpunj	34	10	plays	play	VBZ
cord-306921-3afgpunj	34	11	a	a	DT
cord-306921-3afgpunj	34	12	major	major	JJ
cord-306921-3afgpunj	34	13	role	role	NN
cord-306921-3afgpunj	34	14	in	in	IN
cord-306921-3afgpunj	34	15	hand	hand	NN
cord-306921-3afgpunj	34	16	,	,	,
cord-306921-3afgpunj	34	17	foot	foot	NN
cord-306921-3afgpunj	34	18	and	and	CC
cord-306921-3afgpunj	34	19	mouth	mouth	NN
cord-306921-3afgpunj	34	20	disease	disease	NN
cord-306921-3afgpunj	34	21	(	(	-LRB-
cord-306921-3afgpunj	34	22	HFMD	HFMD	NNP
cord-306921-3afgpunj	34	23	)	)	-RRB-
cord-306921-3afgpunj	34	24	epidemics	epidemic	NNS
cord-306921-3afgpunj	34	25	.	.	.
cord-306921-3afgpunj	35	1	Renal	renal	JJ
cord-306921-3afgpunj	35	2	failure	failure	NN
cord-306921-3afgpunj	35	3	has	have	VBZ
cord-306921-3afgpunj	35	4	also	also	RB
cord-306921-3afgpunj	35	5	been	be	VBN
cord-306921-3afgpunj	35	6	reported	report	VBN
cord-306921-3afgpunj	35	7	in	in	IN
cord-306921-3afgpunj	35	8	two	two	CD
cord-306921-3afgpunj	35	9	HFMD	HFMD	NNP
cord-306921-3afgpunj	35	10	cases	case	NNS
cord-306921-3afgpunj	35	11	due	due	JJ
cord-306921-3afgpunj	35	12	to	to	IN
cord-306921-3afgpunj	35	13	CV	cv	NN
cord-306921-3afgpunj	35	14	-	-	HYPH
cord-306921-3afgpunj	35	15	A16	a16	NN
cord-306921-3afgpunj	35	16	infection	infection	NN
cord-306921-3afgpunj	35	17	[	[	-LRB-
cord-306921-3afgpunj	35	18	9	9	CD
cord-306921-3afgpunj	35	19	,	,	,
cord-306921-3afgpunj	35	20	10	10	CD
cord-306921-3afgpunj	35	21	]	]	-RRB-
cord-306921-3afgpunj	35	22	and	and	CC
cord-306921-3afgpunj	35	23	more	more	RBR
cord-306921-3afgpunj	35	24	recently	recently	RB
cord-306921-3afgpunj	35	25	one	one	CD
cord-306921-3afgpunj	35	26	case	case	NN
cord-306921-3afgpunj	35	27	of	of	IN
cord-306921-3afgpunj	35	28	acute	acute	JJ
cord-306921-3afgpunj	35	29	kidney	kidney	NN
cord-306921-3afgpunj	35	30	injury	injury	NN
cord-306921-3afgpunj	35	31	secondary	secondary	JJ
cord-306921-3afgpunj	35	32	to	to	IN
cord-306921-3afgpunj	35	33	EV	EV	NNP
cord-306921-3afgpunj	35	34	-	-	HYPH
cord-306921-3afgpunj	35	35	A71	A71	NNP
cord-306921-3afgpunj	35	36	infection	infection	NN
cord-306921-3afgpunj	35	37	was	be	VBD
cord-306921-3afgpunj	35	38	reported	report	VBN
cord-306921-3afgpunj	35	39	by	by	IN
cord-306921-3afgpunj	35	40	Xu	Xu	NNP
cord-306921-3afgpunj	35	41	and	and	CC
cord-306921-3afgpunj	35	42	colleagues	colleague	NNS
cord-306921-3afgpunj	35	43	[	[	-LRB-
cord-306921-3afgpunj	35	44	11	11	CD
cord-306921-3afgpunj	35	45	]	]	-RRB-
cord-306921-3afgpunj	35	46	.	.	.
cord-306921-3afgpunj	36	1	HFMD	HFMD	NNP
cord-306921-3afgpunj	36	2	outbreaks	outbreak	NNS
cord-306921-3afgpunj	36	3	have	have	VBP
cord-306921-3afgpunj	36	4	been	be	VBN
cord-306921-3afgpunj	36	5	reported	report	VBN
cord-306921-3afgpunj	36	6	in	in	IN
cord-306921-3afgpunj	36	7	different	different	JJ
cord-306921-3afgpunj	36	8	parts	part	NNS
cord-306921-3afgpunj	36	9	of	of	IN
cord-306921-3afgpunj	36	10	Asia	Asia	NNP
cord-306921-3afgpunj	36	11	Pacific	Pacific	NNP
cord-306921-3afgpunj	36	12	;	;	:
cord-306921-3afgpunj	36	13	often	often	RB
cord-306921-3afgpunj	36	14	with	with	IN
cord-306921-3afgpunj	36	15	neurological	neurological	JJ
cord-306921-3afgpunj	36	16	complications	complication	NNS
cord-306921-3afgpunj	36	17	in	in	IN
cord-306921-3afgpunj	36	18	children	child	NNS
cord-306921-3afgpunj	36	19	under	under	IN
cord-306921-3afgpunj	36	20	the	the	DT
cord-306921-3afgpunj	36	21	age	age	NN
cord-306921-3afgpunj	36	22	of	of	IN
cord-306921-3afgpunj	36	23	five	five	CD
cord-306921-3afgpunj	36	24	especially	especially	RB
cord-306921-3afgpunj	36	25	in	in	IN
cord-306921-3afgpunj	36	26	preschool	preschool	NN
cord-306921-3afgpunj	36	27	centers	center	NNS
cord-306921-3afgpunj	36	28	as	as	IN
cord-306921-3afgpunj	36	29	observed	observe	VBN
cord-306921-3afgpunj	36	30	in	in	IN
cord-306921-3afgpunj	36	31	Singapore	Singapore	NNP
cord-306921-3afgpunj	36	32	[	[	-LRB-
cord-306921-3afgpunj	36	33	12	12	CD
cord-306921-3afgpunj	36	34	]	]	-RRB-
cord-306921-3afgpunj	36	35	.	.	.
cord-306921-3afgpunj	37	1	For	for	IN
cord-306921-3afgpunj	37	2	example	example	NN
cord-306921-3afgpunj	37	3	,	,	,
cord-306921-3afgpunj	37	4	between	between	IN
cord-306921-3afgpunj	37	5	2008	2008	CD
cord-306921-3afgpunj	37	6	to	to	IN
cord-306921-3afgpunj	37	7	2012	2012	CD
cord-306921-3afgpunj	37	8	there	there	EX
cord-306921-3afgpunj	37	9	were	be	VBD
cord-306921-3afgpunj	37	10	about	about	RB
cord-306921-3afgpunj	37	11	7.2	7.2	CD
cord-306921-3afgpunj	37	12	million	million	CD
cord-306921-3afgpunj	37	13	probable	probable	JJ
cord-306921-3afgpunj	37	14	cases	case	NNS
cord-306921-3afgpunj	37	15	of	of	IN
cord-306921-3afgpunj	37	16	HFMD	HFMD	NNP
cord-306921-3afgpunj	37	17	and	and	CC
cord-306921-3afgpunj	37	18	about	about	RB
cord-306921-3afgpunj	37	19	2400	2400	CD
cord-306921-3afgpunj	37	20	fatal	fatal	JJ
cord-306921-3afgpunj	37	21	cases	case	NNS
cord-306921-3afgpunj	37	22	reported	report	VBN
cord-306921-3afgpunj	37	23	in	in	IN
cord-306921-3afgpunj	37	24	mainland	mainland	NN
cord-306921-3afgpunj	37	25	China	China	NNP
cord-306921-3afgpunj	37	26	alone	alone	RB
cord-306921-3afgpunj	37	27	with	with	IN
cord-306921-3afgpunj	37	28	high	high	JJ
cord-306921-3afgpunj	37	29	economic	economic	JJ
cord-306921-3afgpunj	37	30	costs	cost	NNS
cord-306921-3afgpunj	37	31	[	[	-LRB-
cord-306921-3afgpunj	37	32	13	13	CD
cord-306921-3afgpunj	37	33	]	]	-RRB-
cord-306921-3afgpunj	37	34	.	.	.
cord-306921-3afgpunj	38	1	This	this	DT
cord-306921-3afgpunj	38	2	year	year	NN
cord-306921-3afgpunj	38	3	,	,	,
cord-306921-3afgpunj	38	4	34	34	CD
cord-306921-3afgpunj	38	5	cases	case	NNS
cord-306921-3afgpunj	38	6	of	of	IN
cord-306921-3afgpunj	38	7	encephalitis/	encephalitis/	CD
cord-306921-3afgpunj	38	8	neurological	neurological	JJ
cord-306921-3afgpunj	38	9	complications	complication	NNS
cord-306921-3afgpunj	38	10	as	as	IN
cord-306921-3afgpunj	38	11	a	a	DT
cord-306921-3afgpunj	38	12	result	result	NN
cord-306921-3afgpunj	38	13	of	of	IN
cord-306921-3afgpunj	38	14	EV	EV	NNP
cord-306921-3afgpunj	38	15	-	-	HYPH
cord-306921-3afgpunj	38	16	A71	A71	NNP
cord-306921-3afgpunj	38	17	virus	virus	NN
cord-306921-3afgpunj	38	18	infection	infection	NN
cord-306921-3afgpunj	38	19	have	have	VBP
cord-306921-3afgpunj	38	20	been	be	VBN
cord-306921-3afgpunj	38	21	reported	report	VBN
cord-306921-3afgpunj	38	22	in	in	IN
cord-306921-3afgpunj	38	23	Colorado	Colorado	NNP
cord-306921-3afgpunj	38	24	,	,	,
cord-306921-3afgpunj	38	25	United	United	NNP
cord-306921-3afgpunj	38	26	States	States	NNP
cord-306921-3afgpunj	38	27	of	of	IN
cord-306921-3afgpunj	38	28	America	America	NNP
cord-306921-3afgpunj	38	29	[	[	-LRB-
cord-306921-3afgpunj	38	30	14	14	CD
cord-306921-3afgpunj	38	31	]	]	-RRB-
cord-306921-3afgpunj	38	32	.	.	.
cord-306921-3afgpunj	39	1	A	a	DT
cord-306921-3afgpunj	39	2	2	2	CD
cord-306921-3afgpunj	39	3	-	-	SYM
cord-306921-3afgpunj	39	4	3	3	CD
cord-306921-3afgpunj	39	5	yearly	yearly	JJ
cord-306921-3afgpunj	39	6	cyclic	cyclic	JJ
cord-306921-3afgpunj	39	7	pattern	pattern	NN
cord-306921-3afgpunj	39	8	of	of	IN
cord-306921-3afgpunj	39	9	hand	hand	NN
cord-306921-3afgpunj	39	10	,	,	,
cord-306921-3afgpunj	39	11	foot	foot	NN
cord-306921-3afgpunj	39	12	and	and	CC
cord-306921-3afgpunj	39	13	mouth	mouth	NN
cord-306921-3afgpunj	39	14	disease	disease	NN
cord-306921-3afgpunj	39	15	outbreaks	outbreak	NNS
cord-306921-3afgpunj	39	16	have	have	VBP
cord-306921-3afgpunj	39	17	been	be	VBN
cord-306921-3afgpunj	39	18	reported	report	VBN
cord-306921-3afgpunj	39	19	in	in	IN
cord-306921-3afgpunj	39	20	Asia	Asia	NNP
cord-306921-3afgpunj	39	21	pacific	pacific	NNP
cord-306921-3afgpunj	39	22	region	region	NN
cord-306921-3afgpunj	39	23	[	[	-LRB-
cord-306921-3afgpunj	39	24	15	15	CD
cord-306921-3afgpunj	39	25	]	]	-RRB-
cord-306921-3afgpunj	39	26	.	.	.
cord-306921-3afgpunj	40	1	The	the	DT
cord-306921-3afgpunj	40	2	drivers	driver	NNS
cord-306921-3afgpunj	40	3	of	of	IN
cord-306921-3afgpunj	40	4	seasonality	seasonality	NN
cord-306921-3afgpunj	40	5	of	of	IN
cord-306921-3afgpunj	40	6	NPEV	NPEV	NNP
cord-306921-3afgpunj	40	7	in	in	IN
cord-306921-3afgpunj	40	8	USA	USA	NNP
cord-306921-3afgpunj	40	9	was	be	VBD
cord-306921-3afgpunj	40	10	studied	study	VBN
cord-306921-3afgpunj	40	11	recently	recently	RB
cord-306921-3afgpunj	40	12	by	by	IN
cord-306921-3afgpunj	40	13	Pons	Pons	NNP
cord-306921-3afgpunj	40	14	-	-	HYPH
cord-306921-3afgpunj	40	15	Salort	Salort	NNP
cord-306921-3afgpunj	40	16	and	and	CC
cord-306921-3afgpunj	40	17	coworkers	coworker	NNS
cord-306921-3afgpunj	40	18	and	and	CC
cord-306921-3afgpunj	40	19	identified	identify	VBD
cord-306921-3afgpunj	40	20	the	the	DT
cord-306921-3afgpunj	40	21	month	month	NN
cord-306921-3afgpunj	40	22	of	of	IN
cord-306921-3afgpunj	40	23	July	July	NNP
cord-306921-3afgpunj	40	24	and	and	CC
cord-306921-3afgpunj	40	25	September	September	NNP
cord-306921-3afgpunj	40	26	to	to	TO
cord-306921-3afgpunj	40	27	be	be	VB
cord-306921-3afgpunj	40	28	the	the	DT
cord-306921-3afgpunj	40	29	peak	peak	NN
cord-306921-3afgpunj	40	30	of	of	IN
cord-306921-3afgpunj	40	31	these	these	DT
cord-306921-3afgpunj	40	32	infections	infection	NNS
cord-306921-3afgpunj	40	33	[	[	-LRB-
cord-306921-3afgpunj	40	34	16	16	CD
cord-306921-3afgpunj	40	35	]	]	-RRB-
cord-306921-3afgpunj	40	36	.	.	.
cord-306921-3afgpunj	41	1	These	these	DT
cord-306921-3afgpunj	41	2	outbreaks	outbreak	NNS
cord-306921-3afgpunj	41	3	always	always	RB
cord-306921-3afgpunj	41	4	result	result	VBP
cord-306921-3afgpunj	41	5	in	in	IN
cord-306921-3afgpunj	41	6	the	the	DT
cord-306921-3afgpunj	41	7	overburdening	overburdening	NN
cord-306921-3afgpunj	41	8	of	of	IN
cord-306921-3afgpunj	41	9	the	the	DT
cord-306921-3afgpunj	41	10	health	health	NN
cord-306921-3afgpunj	41	11	care	care	NN
cord-306921-3afgpunj	41	12	systems	system	NNS
cord-306921-3afgpunj	41	13	,	,	,
cord-306921-3afgpunj	41	14	pain	pain	NN
cord-306921-3afgpunj	41	15	and	and	CC
cord-306921-3afgpunj	41	16	loss	loss	NN
cord-306921-3afgpunj	41	17	of	of	IN
cord-306921-3afgpunj	41	18	lives	life	NNS
cord-306921-3afgpunj	41	19	in	in	IN
cord-306921-3afgpunj	41	20	severe	severe	JJ
cord-306921-3afgpunj	41	21	cases	case	NNS
cord-306921-3afgpunj	41	22	of	of	IN
cord-306921-3afgpunj	41	23	the	the	DT
cord-306921-3afgpunj	41	24	disease	disease	NN
cord-306921-3afgpunj	41	25	.	.	.
cord-306921-3afgpunj	42	1	Even	even	RB
cord-306921-3afgpunj	42	2	though	though	IN
cord-306921-3afgpunj	42	3	recent	recent	JJ
cord-306921-3afgpunj	42	4	mathematical	mathematical	JJ
cord-306921-3afgpunj	42	5	modelling	modelling	NN
cord-306921-3afgpunj	42	6	findings	finding	NNS
cord-306921-3afgpunj	42	7	using	use	VBG
cord-306921-3afgpunj	42	8	data	datum	NNS
cord-306921-3afgpunj	42	9	from	from	IN
cord-306921-3afgpunj	42	10	Singapore	Singapore	NNP
cord-306921-3afgpunj	42	11	showed	show	VBD
cord-306921-3afgpunj	42	12	high	high	JJ
cord-306921-3afgpunj	42	13	incident	incident	NN
cord-306921-3afgpunj	42	14	rates	rate	NNS
cord-306921-3afgpunj	42	15	with	with	IN
cord-306921-3afgpunj	42	16	limited	limited	JJ
cord-306921-3afgpunj	42	17	disability	disability	NN
cord-306921-3afgpunj	42	18	-	-	HYPH
cord-306921-3afgpunj	42	19	adjusted	adjust	VBN
cord-306921-3afgpunj	42	20	life	life	NN
cord-306921-3afgpunj	42	21	years	year	NNS
cord-306921-3afgpunj	42	22	(	(	-LRB-
cord-306921-3afgpunj	42	23	DALYs	daly	NNS
cord-306921-3afgpunj	42	24	)	)	-RRB-
cord-306921-3afgpunj	42	25	compared	compare	VBN
cord-306921-3afgpunj	42	26	to	to	IN
cord-306921-3afgpunj	42	27	other	other	JJ
cord-306921-3afgpunj	42	28	infectious	infectious	JJ
cord-306921-3afgpunj	42	29	diseases	disease	NNS
cord-306921-3afgpunj	42	30	prevalent	prevalent	JJ
cord-306921-3afgpunj	42	31	in	in	IN
cord-306921-3afgpunj	42	32	the	the	DT
cord-306921-3afgpunj	42	33	South	South	NNP
cord-306921-3afgpunj	42	34	East	East	NNP
cord-306921-3afgpunj	42	35	Asian	asian	JJ
cord-306921-3afgpunj	42	36	countries	country	NNS
cord-306921-3afgpunj	42	37	[	[	-LRB-
cord-306921-3afgpunj	42	38	17	17	CD
cord-306921-3afgpunj	42	39	]	]	-RRB-
cord-306921-3afgpunj	42	40	,	,	,
cord-306921-3afgpunj	42	41	HFMD	HFMD	NNP
cord-306921-3afgpunj	42	42	has	have	VBZ
cord-306921-3afgpunj	42	43	a	a	DT
cord-306921-3afgpunj	42	44	potential	potential	JJ
cord-306921-3afgpunj	42	45	threat	threat	NN
cord-306921-3afgpunj	42	46	to	to	IN
cord-306921-3afgpunj	42	47	global	global	JJ
cord-306921-3afgpunj	42	48	health	health	NN
cord-306921-3afgpunj	42	49	.	.	.
cord-306921-3afgpunj	43	1	Analysis	analysis	NN
cord-306921-3afgpunj	43	2	of	of	IN
cord-306921-3afgpunj	43	3	samples	sample	NNS
cord-306921-3afgpunj	43	4	earlier	early	RBR
cord-306921-3afgpunj	43	5	collected	collect	VBN
cord-306921-3afgpunj	43	6	for	for	IN
cord-306921-3afgpunj	43	7	poliovirus	poliovirus	NN
cord-306921-3afgpunj	43	8	surveillance	surveillance	NN
cord-306921-3afgpunj	43	9	studies	study	NNS
cord-306921-3afgpunj	43	10	in	in	IN
cord-306921-3afgpunj	43	11	seven	seven	CD
cord-306921-3afgpunj	43	12	Western	western	JJ
cord-306921-3afgpunj	43	13	African	african	JJ
cord-306921-3afgpunj	43	14	countries	country	NNS
cord-306921-3afgpunj	43	15	identified	identify	VBD
cord-306921-3afgpunj	43	16	several	several	JJ
cord-306921-3afgpunj	43	17	NPEVs	npev	NNS
cord-306921-3afgpunj	43	18	circulating	circulate	VBG
cord-306921-3afgpunj	43	19	in	in	IN
cord-306921-3afgpunj	43	20	the	the	DT
cord-306921-3afgpunj	43	21	region	region	NN
cord-306921-3afgpunj	43	22	with	with	IN
cord-306921-3afgpunj	43	23	echoviruses	echovirus	NNS
cord-306921-3afgpunj	43	24	being	be	VBG
cord-306921-3afgpunj	43	25	the	the	DT
cord-306921-3afgpunj	43	26	dominant	dominant	JJ
cord-306921-3afgpunj	43	27	strain	strain	NN
cord-306921-3afgpunj	43	28	[	[	-LRB-
cord-306921-3afgpunj	43	29	18	18	CD
cord-306921-3afgpunj	43	30	]	]	-RRB-
cord-306921-3afgpunj	43	31	.	.	.
cord-306921-3afgpunj	44	1	This	this	DT
cord-306921-3afgpunj	44	2	study	study	NN
cord-306921-3afgpunj	44	3	also	also	RB
cord-306921-3afgpunj	44	4	identified	identify	VBD
cord-306921-3afgpunj	44	5	least	least	RBS
cord-306921-3afgpunj	44	6	described	describe	VBD
cord-306921-3afgpunj	44	7	types	type	NNS
cord-306921-3afgpunj	44	8	such	such	JJ
cord-306921-3afgpunj	44	9	as	as	IN
cord-306921-3afgpunj	44	10	EV	EV	NNP
cord-306921-3afgpunj	44	11	-	-	HYPH
cord-306921-3afgpunj	44	12	A119	A119	NNP
cord-306921-3afgpunj	44	13	,	,	,
cord-306921-3afgpunj	44	14	EV	EV	NNP
cord-306921-3afgpunj	44	15	-	-	HYPH
cord-306921-3afgpunj	44	16	B75	B75	NNP
cord-306921-3afgpunj	44	17	,	,	,
cord-306921-3afgpunj	44	18	CV	CV	NNP
cord-306921-3afgpunj	44	19	-	-	HYPH
cord-306921-3afgpunj	44	20	A20	A20	NNP
cord-306921-3afgpunj	44	21	as	as	RB
cord-306921-3afgpunj	44	22	well	well	RB
cord-306921-3afgpunj	44	23	as	as	IN
cord-306921-3afgpunj	44	24	EV	EV	NNP
cord-306921-3afgpunj	44	25	-	-	HYPH
cord-306921-3afgpunj	44	26	D94	D94	NNP
cord-306921-3afgpunj	44	27	among	among	IN
cord-306921-3afgpunj	44	28	others	other	NNS
cord-306921-3afgpunj	44	29	to	to	TO
cord-306921-3afgpunj	44	30	be	be	VB
cord-306921-3afgpunj	44	31	circulating	circulate	VBG
cord-306921-3afgpunj	44	32	in	in	IN
cord-306921-3afgpunj	44	33	this	this	DT
cord-306921-3afgpunj	44	34	region	region	NN
cord-306921-3afgpunj	44	35	[	[	-LRB-
cord-306921-3afgpunj	44	36	18	18	CD
cord-306921-3afgpunj	44	37	]	]	-RRB-
cord-306921-3afgpunj	44	38	.	.	.
cord-306921-3afgpunj	45	1	The	the	DT
cord-306921-3afgpunj	45	2	identification	identification	NN
cord-306921-3afgpunj	45	3	and	and	CC
cord-306921-3afgpunj	45	4	molecular	molecular	JJ
cord-306921-3afgpunj	45	5	characterization	characterization	NN
cord-306921-3afgpunj	45	6	of	of	IN
cord-306921-3afgpunj	45	7	NPEVs	npev	NNS
cord-306921-3afgpunj	45	8	in	in	IN
cord-306921-3afgpunj	45	9	West	West	NNP
cord-306921-3afgpunj	45	10	Africa	Africa	NNP
cord-306921-3afgpunj	45	11	points	point	VBZ
cord-306921-3afgpunj	45	12	to	to	IN
cord-306921-3afgpunj	45	13	the	the	DT
cord-306921-3afgpunj	45	14	global	global	JJ
cord-306921-3afgpunj	45	15	diversity	diversity	NN
cord-306921-3afgpunj	45	16	of	of	IN
cord-306921-3afgpunj	45	17	these	these	DT
cord-306921-3afgpunj	45	18	viruses	virus	NNS
cord-306921-3afgpunj	45	19	and	and	CC
cord-306921-3afgpunj	45	20	calls	call	NNS
cord-306921-3afgpunj	45	21	for	for	IN
cord-306921-3afgpunj	45	22	a	a	DT
cord-306921-3afgpunj	45	23	stronger	strong	JJR
cord-306921-3afgpunj	45	24	surveillance	surveillance	NN
cord-306921-3afgpunj	45	25	system	system	NN
cord-306921-3afgpunj	45	26	for	for	IN
cord-306921-3afgpunj	45	27	better	well	JJR
cord-306921-3afgpunj	45	28	management	management	NN
cord-306921-3afgpunj	45	29	and	and	CC
cord-306921-3afgpunj	45	30	control	control	NN
cord-306921-3afgpunj	45	31	.	.	.
cord-306921-3afgpunj	46	1	Recently	recently	RB
cord-306921-3afgpunj	46	2	,	,	,
cord-306921-3afgpunj	46	3	minor	minor	JJ
cord-306921-3afgpunj	46	4	outbreaks	outbreak	NNS
cord-306921-3afgpunj	46	5	of	of	IN
cord-306921-3afgpunj	46	6	HFMD	HFMD	NNP
cord-306921-3afgpunj	46	7	have	have	VBP
cord-306921-3afgpunj	46	8	been	be	VBN
cord-306921-3afgpunj	46	9	attributed	attribute	VBN
cord-306921-3afgpunj	46	10	to	to	IN
cord-306921-3afgpunj	46	11	other	other	JJ
cord-306921-3afgpunj	46	12	coxsackieviruses	coxsackievirus	NNS
cord-306921-3afgpunj	46	13	such	such	JJ
cord-306921-3afgpunj	46	14	as	as	IN
cord-306921-3afgpunj	46	15	CV	CV	NNP
cord-306921-3afgpunj	46	16	-	-	HYPH
cord-306921-3afgpunj	46	17	A10	A10	NNP
cord-306921-3afgpunj	46	18	and	and	CC
cord-306921-3afgpunj	46	19	CV	CV	NNP
cord-306921-3afgpunj	46	20	-	-	HYPH
cord-306921-3afgpunj	46	21	A6	A6	NNP
cord-306921-3afgpunj	46	22	.	.	.
cord-306921-3afgpunj	47	1	Even	even	RB
cord-306921-3afgpunj	47	2	though	though	IN
cord-306921-3afgpunj	47	3	the	the	DT
cord-306921-3afgpunj	47	4	magnitude	magnitude	NN
cord-306921-3afgpunj	47	5	of	of	IN
cord-306921-3afgpunj	47	6	their	-PRON-	PRP$
cord-306921-3afgpunj	47	7	effects	effect	NNS
cord-306921-3afgpunj	47	8	during	during	IN
cord-306921-3afgpunj	47	9	outbreaks	outbreak	NNS
cord-306921-3afgpunj	47	10	is	be	VBZ
cord-306921-3afgpunj	47	11	not	not	RB
cord-306921-3afgpunj	47	12	as	as	RB
cord-306921-3afgpunj	47	13	large	large	JJ
cord-306921-3afgpunj	47	14	as	as	IN
cord-306921-3afgpunj	47	15	that	that	DT
cord-306921-3afgpunj	47	16	of	of	IN
cord-306921-3afgpunj	47	17	EV	EV	NNP
cord-306921-3afgpunj	47	18	-	-	HYPH
cord-306921-3afgpunj	47	19	A71	A71	NNP
cord-306921-3afgpunj	47	20	and	and	CC
cord-306921-3afgpunj	47	21	CV	CV	NNP
cord-306921-3afgpunj	47	22	-	-	HYPH
cord-306921-3afgpunj	47	23	A16	A16	NNP
cord-306921-3afgpunj	47	24	;	;	:
cord-306921-3afgpunj	47	25	there	there	EX
cord-306921-3afgpunj	47	26	is	be	VBZ
cord-306921-3afgpunj	47	27	need	need	NN
cord-306921-3afgpunj	47	28	to	to	TO
cord-306921-3afgpunj	47	29	understand	understand	VB
cord-306921-3afgpunj	47	30	pathogenesis	pathogenesis	NN
cord-306921-3afgpunj	47	31	of	of	IN
cord-306921-3afgpunj	47	32	the	the	DT
cord-306921-3afgpunj	47	33	infections	infection	NNS
cord-306921-3afgpunj	47	34	as	as	RB
cord-306921-3afgpunj	47	35	well	well	RB
cord-306921-3afgpunj	47	36	as	as	IN
cord-306921-3afgpunj	47	37	quantifying	quantify	VBG
cord-306921-3afgpunj	47	38	their	-PRON-	PRP$
cord-306921-3afgpunj	47	39	burden	burden	NN
cord-306921-3afgpunj	47	40	for	for	IN
cord-306921-3afgpunj	47	41	easy	easy	JJ
cord-306921-3afgpunj	47	42	disease	disease	NN
cord-306921-3afgpunj	47	43	monitoring	monitoring	NN
cord-306921-3afgpunj	47	44	.	.	.
cord-306921-3afgpunj	48	1	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	48	2	A6	A6	NNP
cord-306921-3afgpunj	48	3	(	(	-LRB-
cord-306921-3afgpunj	48	4	CV	CV	NNP
cord-306921-3afgpunj	48	5	-	-	HYPH
cord-306921-3afgpunj	48	6	A6	A6	NNP
cord-306921-3afgpunj	48	7	)	)	-RRB-
cord-306921-3afgpunj	48	8	was	be	VBD
cord-306921-3afgpunj	48	9	isolated	isolate	VBN
cord-306921-3afgpunj	48	10	in	in	IN
cord-306921-3afgpunj	48	11	USA	USA	NNP
cord-306921-3afgpunj	48	12	in	in	IN
cord-306921-3afgpunj	48	13	1949	1949	CD
cord-306921-3afgpunj	48	14	and	and	CC
cord-306921-3afgpunj	48	15	has	have	VBZ
cord-306921-3afgpunj	48	16	been	be	VBN
cord-306921-3afgpunj	48	17	recognized	recognize	VBN
cord-306921-3afgpunj	48	18	as	as	IN
cord-306921-3afgpunj	48	19	one	one	CD
cord-306921-3afgpunj	48	20	of	of	IN
cord-306921-3afgpunj	48	21	the	the	DT
cord-306921-3afgpunj	48	22	causative	causative	JJ
cord-306921-3afgpunj	48	23	agents	agent	NNS
cord-306921-3afgpunj	48	24	of	of	IN
cord-306921-3afgpunj	48	25	hand	hand	NN
cord-306921-3afgpunj	48	26	,	,	,
cord-306921-3afgpunj	48	27	foot	foot	NN
cord-306921-3afgpunj	48	28	and	and	CC
cord-306921-3afgpunj	48	29	mouth	mouth	NN
cord-306921-3afgpunj	48	30	disease	disease	NN
cord-306921-3afgpunj	48	31	in	in	IN
cord-306921-3afgpunj	48	32	different	different	JJ
cord-306921-3afgpunj	48	33	parts	part	NNS
cord-306921-3afgpunj	48	34	of	of	IN
cord-306921-3afgpunj	48	35	the	the	DT
cord-306921-3afgpunj	48	36	world	world	NN
cord-306921-3afgpunj	48	37	including	include	VBG
cord-306921-3afgpunj	48	38	USA	USA	NNP
cord-306921-3afgpunj	48	39	,	,	,
cord-306921-3afgpunj	48	40	Europe	Europe	NNP
cord-306921-3afgpunj	48	41	(	(	-LRB-
cord-306921-3afgpunj	48	42	Finland	Finland	NNP
cord-306921-3afgpunj	48	43	,	,	,
cord-306921-3afgpunj	48	44	Spain	Spain	NNP
cord-306921-3afgpunj	48	45	)	)	-RRB-
cord-306921-3afgpunj	48	46	and	and	CC
cord-306921-3afgpunj	48	47	Asia	Asia	NNP
cord-306921-3afgpunj	48	48	Pacific	Pacific	NNP
cord-306921-3afgpunj	48	49	(	(	-LRB-
cord-306921-3afgpunj	48	50	Taiwan	Taiwan	NNP
cord-306921-3afgpunj	48	51	,	,	,
cord-306921-3afgpunj	48	52	Japan	Japan	NNP
cord-306921-3afgpunj	48	53	,	,	,
cord-306921-3afgpunj	48	54	China	China	NNP
cord-306921-3afgpunj	48	55	,	,	,
cord-306921-3afgpunj	48	56	Thailand	Thailand	NNP
cord-306921-3afgpunj	48	57	and	and	CC
cord-306921-3afgpunj	48	58	Vietnam	Vietnam	NNP
cord-306921-3afgpunj	48	59	among	among	IN
cord-306921-3afgpunj	48	60	other	other	JJ
cord-306921-3afgpunj	48	61	countries	country	NNS
cord-306921-3afgpunj	48	62	in	in	IN
cord-306921-3afgpunj	48	63	the	the	DT
cord-306921-3afgpunj	48	64	region	region	NN
cord-306921-3afgpunj	48	65	)	)	-RRB-
cord-306921-3afgpunj	49	1	[	[	-LRB-
cord-306921-3afgpunj	49	2	19	19	CD
cord-306921-3afgpunj	49	3	]	]	-RRB-
cord-306921-3afgpunj	49	4	[	[	-LRB-
cord-306921-3afgpunj	49	5	20	20	CD
cord-306921-3afgpunj	49	6	]	]	-RRB-
cord-306921-3afgpunj	49	7	[	[	-LRB-
cord-306921-3afgpunj	49	8	21	21	CD
cord-306921-3afgpunj	49	9	]	]	-RRB-
cord-306921-3afgpunj	50	1	[	[	-LRB-
cord-306921-3afgpunj	50	2	22	22	CD
cord-306921-3afgpunj	50	3	]	]	-RRB-
cord-306921-3afgpunj	50	4	[	[	-LRB-
cord-306921-3afgpunj	50	5	23	23	CD
cord-306921-3afgpunj	50	6	]	]	-RRB-
cord-306921-3afgpunj	51	1	[	[	-LRB-
cord-306921-3afgpunj	51	2	24	24	CD
cord-306921-3afgpunj	51	3	]	]	-RRB-
cord-306921-3afgpunj	51	4	[	[	-LRB-
cord-306921-3afgpunj	51	5	25	25	CD
cord-306921-3afgpunj	51	6	]	]	-RRB-
cord-306921-3afgpunj	51	7	[	[	-LRB-
cord-306921-3afgpunj	51	8	26	26	CD
cord-306921-3afgpunj	51	9	]	]	-RRB-
cord-306921-3afgpunj	51	10	[	[	-LRB-
cord-306921-3afgpunj	51	11	27	27	CD
cord-306921-3afgpunj	51	12	]	]	-RRB-
cord-306921-3afgpunj	51	13	.	.	.
cord-306921-3afgpunj	52	1	The	the	DT
cord-306921-3afgpunj	52	2	emergence	emergence	NN
cord-306921-3afgpunj	52	3	of	of	IN
cord-306921-3afgpunj	52	4	CV	CV	NNP
cord-306921-3afgpunj	52	5	-	-	HYPH
cord-306921-3afgpunj	52	6	A6	A6	NNP
cord-306921-3afgpunj	52	7	as	as	IN
cord-306921-3afgpunj	52	8	a	a	DT
cord-306921-3afgpunj	52	9	player	player	NN
cord-306921-3afgpunj	52	10	in	in	IN
cord-306921-3afgpunj	52	11	the	the	DT
cord-306921-3afgpunj	52	12	HFMD	HFMD	NNP
cord-306921-3afgpunj	52	13	outbreaks	outbreak	NNS
cord-306921-3afgpunj	52	14	eventually	eventually	RB
cord-306921-3afgpunj	52	15	complicates	complicate	VBZ
cord-306921-3afgpunj	52	16	vaccine	vaccine	NN
cord-306921-3afgpunj	52	17	and	and	CC
cord-306921-3afgpunj	52	18	antiviral	antiviral	JJ
cord-306921-3afgpunj	52	19	therapy	therapy	NN
cord-306921-3afgpunj	52	20	development	development	NN
cord-306921-3afgpunj	52	21	against	against	IN
cord-306921-3afgpunj	52	22	HFMD	HFMD	NNP
cord-306921-3afgpunj	52	23	.	.	.
cord-306921-3afgpunj	53	1	CV	cv	NN
cord-306921-3afgpunj	53	2	-	-	HYPH
cord-306921-3afgpunj	53	3	A16	A16	NNP
cord-306921-3afgpunj	53	4	and	and	CC
cord-306921-3afgpunj	53	5	EV	EV	NNP
cord-306921-3afgpunj	53	6	-	-	HYPH
cord-306921-3afgpunj	53	7	A71	A71	NNP
cord-306921-3afgpunj	53	8	have	have	VBP
cord-306921-3afgpunj	53	9	been	be	VBN
cord-306921-3afgpunj	53	10	broadly	broadly	RB
cord-306921-3afgpunj	53	11	studied	study	VBN
cord-306921-3afgpunj	53	12	;	;	:
cord-306921-3afgpunj	53	13	however	however	WRB
cord-306921-3afgpunj	53	14	little	little	JJ
cord-306921-3afgpunj	53	15	success	success	NN
cord-306921-3afgpunj	53	16	has	have	VBZ
cord-306921-3afgpunj	53	17	been	be	VBN
cord-306921-3afgpunj	53	18	achieved	achieve	VBN
cord-306921-3afgpunj	53	19	in	in	IN
cord-306921-3afgpunj	53	20	vaccine	vaccine	NN
cord-306921-3afgpunj	53	21	and	and	CC
cord-306921-3afgpunj	53	22	therapy	therapy	NN
cord-306921-3afgpunj	53	23	development	development	NN
cord-306921-3afgpunj	53	24	thus	thus	RB
cord-306921-3afgpunj	53	25	the	the	DT
cord-306921-3afgpunj	53	26	emergence	emergence	NN
cord-306921-3afgpunj	53	27	of	of	IN
cord-306921-3afgpunj	53	28	CV	CV	NNP
cord-306921-3afgpunj	53	29	-	-	HYPH
cord-306921-3afgpunj	53	30	A6	A6	NNP
cord-306921-3afgpunj	53	31	points	point	NNS
cord-306921-3afgpunj	53	32	to	to	IN
cord-306921-3afgpunj	53	33	the	the	DT
cord-306921-3afgpunj	53	34	urgent	urgent	JJ
cord-306921-3afgpunj	53	35	need	need	NN
cord-306921-3afgpunj	53	36	of	of	IN
cord-306921-3afgpunj	53	37	understanding	understand	VBG
cord-306921-3afgpunj	53	38	its	-PRON-	PRP$
cord-306921-3afgpunj	53	39	infection	infection	NN
cord-306921-3afgpunj	53	40	dynamics	dynamic	NNS
cord-306921-3afgpunj	53	41	.	.	.
cord-306921-3afgpunj	54	1	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	54	2	A6	A6	NNP
cord-306921-3afgpunj	54	3	and	and	CC
cord-306921-3afgpunj	54	4	A10	A10	NNP
cord-306921-3afgpunj	54	5	have	have	VBP
cord-306921-3afgpunj	54	6	been	be	VBN
cord-306921-3afgpunj	54	7	linked	link	VBN
cord-306921-3afgpunj	54	8	to	to	IN
cord-306921-3afgpunj	54	9	sporadic	sporadic	JJ
cord-306921-3afgpunj	54	10	outbreaks	outbreak	NNS
cord-306921-3afgpunj	54	11	of	of	IN
cord-306921-3afgpunj	54	12	atypical	atypical	JJ
cord-306921-3afgpunj	54	13	HFMD	HFMD	NNP
cord-306921-3afgpunj	54	14	infections	infection	NNS
cord-306921-3afgpunj	54	15	in	in	IN
cord-306921-3afgpunj	54	16	China	China	NNP
cord-306921-3afgpunj	54	17	and	and	CC
cord-306921-3afgpunj	54	18	France	France	NNP
cord-306921-3afgpunj	54	19	[	[	-LRB-
cord-306921-3afgpunj	54	20	28	28	CD
cord-306921-3afgpunj	54	21	]	]	-RRB-
cord-306921-3afgpunj	54	22	[	[	-LRB-
cord-306921-3afgpunj	54	23	29	29	CD
cord-306921-3afgpunj	54	24	]	]	-RRB-
cord-306921-3afgpunj	55	1	[	[	-LRB-
cord-306921-3afgpunj	55	2	30	30	CD
cord-306921-3afgpunj	55	3	]	]	-RRB-
cord-306921-3afgpunj	55	4	[	[	-LRB-
cord-306921-3afgpunj	55	5	31	31	CD
cord-306921-3afgpunj	55	6	]	]	-RRB-
cord-306921-3afgpunj	55	7	[	[	-LRB-
cord-306921-3afgpunj	55	8	32	32	CD
cord-306921-3afgpunj	55	9	]	]	-RRB-
cord-306921-3afgpunj	55	10	.	.	.
cord-306921-3afgpunj	56	1	Between	between	IN
cord-306921-3afgpunj	56	2	2009	2009	CD
cord-306921-3afgpunj	56	3	and	and	CC
cord-306921-3afgpunj	56	4	2011	2011	CD
cord-306921-3afgpunj	56	5	,	,	,
cord-306921-3afgpunj	56	6	CV	CV	NNP
cord-306921-3afgpunj	56	7	-	-	HYPH
cord-306921-3afgpunj	56	8	A10	A10	NNP
cord-306921-3afgpunj	56	9	and	and	CC
cord-306921-3afgpunj	56	10	CV	CV	NNP
cord-306921-3afgpunj	56	11	-	-	HYPH
cord-306921-3afgpunj	56	12	A6	A6	NNP
cord-306921-3afgpunj	56	13	contributed	contribute	VBD
cord-306921-3afgpunj	56	14	to	to	IN
cord-306921-3afgpunj	56	15	about	about	IN
cord-306921-3afgpunj	56	16	4.7	4.7	CD
cord-306921-3afgpunj	56	17	and	and	CC
cord-306921-3afgpunj	56	18	2.5	2.5	CD
cord-306921-3afgpunj	56	19	%	%	NN
cord-306921-3afgpunj	56	20	cases	case	NNS
cord-306921-3afgpunj	56	21	of	of	IN
cord-306921-3afgpunj	56	22	HFMD	HFMD	NNP
cord-306921-3afgpunj	56	23	correspondingly	correspondingly	RB
cord-306921-3afgpunj	56	24	in	in	IN
cord-306921-3afgpunj	56	25	China	China	NNP
cord-306921-3afgpunj	56	26	[	[	-LRB-
cord-306921-3afgpunj	56	27	32	32	CD
cord-306921-3afgpunj	56	28	]	]	-RRB-
cord-306921-3afgpunj	56	29	.	.	.
cord-306921-3afgpunj	57	1	With	with	IN
cord-306921-3afgpunj	57	2	time	time	NN
cord-306921-3afgpunj	57	3	,	,	,
cord-306921-3afgpunj	57	4	CV	CV	NNP
cord-306921-3afgpunj	57	5	-	-	HYPH
cord-306921-3afgpunj	57	6	A6	A6	NNP
cord-306921-3afgpunj	57	7	has	have	VBZ
cord-306921-3afgpunj	57	8	become	become	VBN
cord-306921-3afgpunj	57	9	one	one	CD
cord-306921-3afgpunj	57	10	of	of	IN
cord-306921-3afgpunj	57	11	the	the	DT
cord-306921-3afgpunj	57	12	major	major	JJ
cord-306921-3afgpunj	57	13	causative	causative	JJ
cord-306921-3afgpunj	57	14	agents	agent	NNS
cord-306921-3afgpunj	57	15	of	of	IN
cord-306921-3afgpunj	57	16	both	both	CC
cord-306921-3afgpunj	57	17	severe	severe	JJ
cord-306921-3afgpunj	57	18	and	and	CC
cord-306921-3afgpunj	57	19	mild	mild	JJ
cord-306921-3afgpunj	57	20	cases	case	NNS
cord-306921-3afgpunj	57	21	of	of	IN
cord-306921-3afgpunj	57	22	hand	hand	NN
cord-306921-3afgpunj	57	23	,	,	,
cord-306921-3afgpunj	57	24	foot	foot	NN
cord-306921-3afgpunj	57	25	and	and	CC
cord-306921-3afgpunj	57	26	mouth	mouth	NN
cord-306921-3afgpunj	57	27	disease	disease	NN
cord-306921-3afgpunj	57	28	in	in	IN
cord-306921-3afgpunj	57	29	China	China	NNP
cord-306921-3afgpunj	57	30	between	between	IN
cord-306921-3afgpunj	57	31	2013	2013	CD
cord-306921-3afgpunj	57	32	to	to	IN
cord-306921-3afgpunj	57	33	2015	2015	CD
cord-306921-3afgpunj	57	34	;	;	:
cord-306921-3afgpunj	57	35	accounting	account	VBG
cord-306921-3afgpunj	57	36	for	for	IN
cord-306921-3afgpunj	57	37	approximately	approximately	RB
cord-306921-3afgpunj	57	38	25.8	25.8	CD
cord-306921-3afgpunj	57	39	%	%	NN
cord-306921-3afgpunj	57	40	of	of	IN
cord-306921-3afgpunj	57	41	mild	mild	JJ
cord-306921-3afgpunj	57	42	and	and	CC
cord-306921-3afgpunj	57	43	16.9	16.9	CD
cord-306921-3afgpunj	57	44	%	%	NN
cord-306921-3afgpunj	57	45	of	of	IN
cord-306921-3afgpunj	57	46	severe	severe	JJ
cord-306921-3afgpunj	57	47	cases	case	NNS
cord-306921-3afgpunj	57	48	in	in	IN
cord-306921-3afgpunj	57	49	2015	2015	CD
cord-306921-3afgpunj	57	50	[	[	-LRB-
cord-306921-3afgpunj	57	51	33	33	CD
cord-306921-3afgpunj	57	52	]	]	-RRB-
cord-306921-3afgpunj	57	53	.	.	.
cord-306921-3afgpunj	58	1	There	there	EX
cord-306921-3afgpunj	58	2	is	be	VBZ
cord-306921-3afgpunj	58	3	a	a	DT
cord-306921-3afgpunj	58	4	high	high	JJ
cord-306921-3afgpunj	58	5	possibility	possibility	NN
cord-306921-3afgpunj	58	6	of	of	IN
cord-306921-3afgpunj	58	7	virulent	virulent	JJ
cord-306921-3afgpunj	58	8	strains	strain	NNS
cord-306921-3afgpunj	58	9	of	of	IN
cord-306921-3afgpunj	58	10	HFMD	HFMD	NNP
cord-306921-3afgpunj	58	11	viruses	virus	NNS
cord-306921-3afgpunj	58	12	emerging	emerge	VBG
cord-306921-3afgpunj	58	13	as	as	IN
cord-306921-3afgpunj	58	14	frequent	frequent	JJ
cord-306921-3afgpunj	58	15	recombination	recombination	NN
cord-306921-3afgpunj	58	16	of	of	IN
cord-306921-3afgpunj	58	17	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	58	18	A	A	NNP
cord-306921-3afgpunj	58	19	have	have	VBP
cord-306921-3afgpunj	58	20	been	be	VBN
cord-306921-3afgpunj	58	21	reported	report	VBN
cord-306921-3afgpunj	58	22	[	[	-LRB-
cord-306921-3afgpunj	58	23	30	30	CD
cord-306921-3afgpunj	58	24	,	,	,
cord-306921-3afgpunj	58	25	34	34	CD
cord-306921-3afgpunj	58	26	]	]	-RRB-
cord-306921-3afgpunj	58	27	.	.	.
cord-306921-3afgpunj	59	1	These	these	DT
cord-306921-3afgpunj	59	2	viruses	virus	NNS
cord-306921-3afgpunj	59	3	have	have	VBP
cord-306921-3afgpunj	59	4	a	a	DT
cord-306921-3afgpunj	59	5	potential	potential	NN
cord-306921-3afgpunj	59	6	of	of	IN
cord-306921-3afgpunj	59	7	causing	cause	VBG
cord-306921-3afgpunj	59	8	major	major	JJ
cord-306921-3afgpunj	59	9	outbreaks	outbreak	NNS
cord-306921-3afgpunj	59	10	with	with	IN
cord-306921-3afgpunj	59	11	potential	potential	JJ
cord-306921-3afgpunj	59	12	threat	threat	NN
cord-306921-3afgpunj	59	13	to	to	IN
cord-306921-3afgpunj	59	14	global	global	JJ
cord-306921-3afgpunj	59	15	health	health	NN
cord-306921-3afgpunj	59	16	.	.	.
cord-306921-3afgpunj	60	1	Enterovirus	enterovirus	NN
cord-306921-3afgpunj	60	2	D	D	NNP
cord-306921-3afgpunj	60	3	68	68	CD
cord-306921-3afgpunj	60	4	(	(	-LRB-
cord-306921-3afgpunj	60	5	EV	EV	NNP
cord-306921-3afgpunj	60	6	-	-	HYPH
cord-306921-3afgpunj	60	7	D68	D68	NNP
cord-306921-3afgpunj	60	8	)	)	-RRB-
cord-306921-3afgpunj	60	9	;	;	:
cord-306921-3afgpunj	60	10	first	first	RB
cord-306921-3afgpunj	60	11	identified	identify	VBN
cord-306921-3afgpunj	60	12	from	from	IN
cord-306921-3afgpunj	60	13	throat	throat	NN
cord-306921-3afgpunj	60	14	swabs	swab	NNS
cord-306921-3afgpunj	60	15	of	of	IN
cord-306921-3afgpunj	60	16	children	child	NNS
cord-306921-3afgpunj	60	17	suffering	suffer	VBG
cord-306921-3afgpunj	60	18	from	from	IN
cord-306921-3afgpunj	60	19	respiratory	respiratory	JJ
cord-306921-3afgpunj	60	20	infections	infection	NNS
cord-306921-3afgpunj	60	21	in	in	IN
cord-306921-3afgpunj	60	22	1962	1962	CD
cord-306921-3afgpunj	60	23	and	and	CC
cord-306921-3afgpunj	60	24	named	name	VBN
cord-306921-3afgpunj	60	25	as	as	IN
cord-306921-3afgpunj	60	26	"	"	``
cord-306921-3afgpunj	60	27	Fermon	Fermon	NNP
cord-306921-3afgpunj	60	28	virus	virus	NN
cord-306921-3afgpunj	60	29	"	"	''
cord-306921-3afgpunj	60	30	by	by	IN
cord-306921-3afgpunj	60	31	Schieble	Schieble	NNP
cord-306921-3afgpunj	60	32	and	and	CC
cord-306921-3afgpunj	60	33	coworkers	coworker	NNS
cord-306921-3afgpunj	60	34	[	[	-LRB-
cord-306921-3afgpunj	60	35	35	35	CD
cord-306921-3afgpunj	60	36	]	]	-RRB-
cord-306921-3afgpunj	60	37	.	.	.
cord-306921-3afgpunj	61	1	Since	since	IN
cord-306921-3afgpunj	61	2	then	then	RB
cord-306921-3afgpunj	61	3	,	,	,
cord-306921-3afgpunj	61	4	severe	severe	JJ
cord-306921-3afgpunj	61	5	outbreaks	outbreak	NNS
cord-306921-3afgpunj	61	6	of	of	IN
cord-306921-3afgpunj	61	7	respiratory	respiratory	JJ
cord-306921-3afgpunj	61	8	infections	infection	NNS
cord-306921-3afgpunj	61	9	as	as	IN
cord-306921-3afgpunj	61	10	a	a	DT
cord-306921-3afgpunj	61	11	result	result	NN
cord-306921-3afgpunj	61	12	of	of	IN
cord-306921-3afgpunj	61	13	Enterovirus	enterovirus	NN
cord-306921-3afgpunj	61	14	D	D	NNP
cord-306921-3afgpunj	61	15	68	68	CD
cord-306921-3afgpunj	61	16	infections	infection	NNS
cord-306921-3afgpunj	61	17	have	have	VBP
cord-306921-3afgpunj	61	18	been	be	VBN
cord-306921-3afgpunj	61	19	reported	report	VBN
cord-306921-3afgpunj	61	20	in	in	IN
cord-306921-3afgpunj	61	21	Taiwan	Taiwan	NNP
cord-306921-3afgpunj	61	22	,	,	,
cord-306921-3afgpunj	61	23	USA	USA	NNP
cord-306921-3afgpunj	61	24	,	,	,
cord-306921-3afgpunj	61	25	Canada	Canada	NNP
cord-306921-3afgpunj	61	26	and	and	CC
cord-306921-3afgpunj	61	27	in	in	IN
cord-306921-3afgpunj	61	28	Europe	Europe	NNP
cord-306921-3afgpunj	61	29	among	among	IN
cord-306921-3afgpunj	61	30	other	other	JJ
cord-306921-3afgpunj	61	31	endemic	endemic	JJ
cord-306921-3afgpunj	61	32	regions	region	NNS
cord-306921-3afgpunj	61	33	[	[	-LRB-
cord-306921-3afgpunj	61	34	17	17	CD
cord-306921-3afgpunj	61	35	,	,	,
cord-306921-3afgpunj	61	36	[	[	-LRB-
cord-306921-3afgpunj	61	37	36	36	CD
cord-306921-3afgpunj	61	38	]	]	-RRB-
cord-306921-3afgpunj	61	39	[	[	-LRB-
cord-306921-3afgpunj	61	40	37	37	CD
cord-306921-3afgpunj	61	41	]	]	-RRB-
cord-306921-3afgpunj	61	42	[	[	-LRB-
cord-306921-3afgpunj	61	43	38	38	CD
cord-306921-3afgpunj	61	44	]	]	-RRB-
cord-306921-3afgpunj	61	45	.	.	.
cord-306921-3afgpunj	62	1	The	the	DT
cord-306921-3afgpunj	62	2	link	link	NN
cord-306921-3afgpunj	62	3	to	to	IN
cord-306921-3afgpunj	62	4	acute	acute	JJ
cord-306921-3afgpunj	62	5	flaccid	flaccid	JJ
cord-306921-3afgpunj	62	6	paralysis	paralysis	NN
cord-306921-3afgpunj	62	7	and	and	CC
cord-306921-3afgpunj	62	8	acute	acute	JJ
cord-306921-3afgpunj	62	9	flaccid	flaccid	JJ
cord-306921-3afgpunj	62	10	myelitis	myelitis	NN
cord-306921-3afgpunj	62	11	further	further	RB
cord-306921-3afgpunj	62	12	exacerbates	exacerbate	VBZ
cord-306921-3afgpunj	62	13	EV	EV	NNP
cord-306921-3afgpunj	62	14	-	-	HYPH
cord-306921-3afgpunj	62	15	D68	D68	NNP
cord-306921-3afgpunj	62	16	infections	infection	NNS
cord-306921-3afgpunj	62	17	[	[	-LRB-
cord-306921-3afgpunj	62	18	39	39	CD
cord-306921-3afgpunj	62	19	]	]	-RRB-
cord-306921-3afgpunj	62	20	.	.	.
cord-306921-3afgpunj	63	1	Several	several	JJ
cord-306921-3afgpunj	63	2	research	research	NN
cord-306921-3afgpunj	63	3	studies	study	NNS
cord-306921-3afgpunj	63	4	have	have	VBP
cord-306921-3afgpunj	63	5	demonstrated	demonstrate	VBN
cord-306921-3afgpunj	63	6	the	the	DT
cord-306921-3afgpunj	63	7	infection	infection	NN
cord-306921-3afgpunj	63	8	dynamics	dynamic	NNS
cord-306921-3afgpunj	63	9	of	of	IN
cord-306921-3afgpunj	63	10	this	this	DT
cord-306921-3afgpunj	63	11	viral	viral	JJ
cord-306921-3afgpunj	63	12	infection	infection	NN
cord-306921-3afgpunj	63	13	;	;	:
cord-306921-3afgpunj	63	14	for	for	IN
cord-306921-3afgpunj	63	15	example	example	NN
cord-306921-3afgpunj	63	16	,	,	,
cord-306921-3afgpunj	63	17	the	the	DT
cord-306921-3afgpunj	63	18	ability	ability	NN
cord-306921-3afgpunj	63	19	of	of	IN
cord-306921-3afgpunj	63	20	EV	EV	NNP
cord-306921-3afgpunj	63	21	-	-	HYPH
cord-306921-3afgpunj	63	22	D68	D68	NNP
cord-306921-3afgpunj	63	23	to	to	TO
cord-306921-3afgpunj	63	24	infect	infect	VB
cord-306921-3afgpunj	63	25	neuronal	neuronal	JJ
cord-306921-3afgpunj	63	26	cells	cell	NNS
cord-306921-3afgpunj	63	27	has	have	VBZ
cord-306921-3afgpunj	63	28	been	be	VBN
cord-306921-3afgpunj	63	29	reported	report	VBN
cord-306921-3afgpunj	63	30	by	by	IN
cord-306921-3afgpunj	63	31	Brown	Brown	NNP
cord-306921-3afgpunj	63	32	and	and	CC
cord-306921-3afgpunj	63	33	colleagues	colleague	NNS
cord-306921-3afgpunj	63	34	.	.	.
cord-306921-3afgpunj	64	1	Using	use	VBG
cord-306921-3afgpunj	64	2	neuronal	neuronal	JJ
cord-306921-3afgpunj	64	3	cell	cell	NN
cord-306921-3afgpunj	64	4	line	line	NN
cord-306921-3afgpunj	64	5	;	;	:
cord-306921-3afgpunj	64	6	SH	sh	NN
cord-306921-3afgpunj	64	7	-	-	HYPH
cord-306921-3afgpunj	64	8	SY5Y	SY5Y	NNP
cord-306921-3afgpunj	64	9	confirming	confirm	VBG
cord-306921-3afgpunj	64	10	its	-PRON-	PRP$
cord-306921-3afgpunj	64	11	neurotropism	neurotropism	NN
cord-306921-3afgpunj	64	12	in	in	IN
cord-306921-3afgpunj	64	13	line	line	NN
cord-306921-3afgpunj	64	14	with	with	IN
cord-306921-3afgpunj	64	15	the	the	DT
cord-306921-3afgpunj	64	16	observed	observed	JJ
cord-306921-3afgpunj	64	17	acute	acute	JJ
cord-306921-3afgpunj	64	18	flaccid	flaccid	JJ
cord-306921-3afgpunj	64	19	myelitis/	myelitis/	CD
cord-306921-3afgpunj	64	20	paralysis	paralysis	NN
cord-306921-3afgpunj	64	21	in	in	IN
cord-306921-3afgpunj	64	22	patients	patient	NNS
cord-306921-3afgpunj	64	23	[	[	-LRB-
cord-306921-3afgpunj	64	24	40	40	CD
cord-306921-3afgpunj	64	25	]	]	-RRB-
cord-306921-3afgpunj	64	26	.	.	.
cord-306921-3afgpunj	65	1	Systemic	systemic	JJ
cord-306921-3afgpunj	65	2	and	and	CC
cord-306921-3afgpunj	65	3	molecular	molecular	JJ
cord-306921-3afgpunj	65	4	diversity	diversity	NN
cord-306921-3afgpunj	65	5	studies	study	NNS
cord-306921-3afgpunj	65	6	of	of	IN
cord-306921-3afgpunj	65	7	EV	EV	NNP
cord-306921-3afgpunj	65	8	-	-	HYPH
cord-306921-3afgpunj	65	9	D68	D68	NNP
cord-306921-3afgpunj	65	10	in	in	IN
cord-306921-3afgpunj	65	11	Lyon	Lyon	NNP
cord-306921-3afgpunj	65	12	France	France	NNP
cord-306921-3afgpunj	65	13	,	,	,
cord-306921-3afgpunj	65	14	showed	show	VBD
cord-306921-3afgpunj	65	15	a	a	DT
cord-306921-3afgpunj	65	16	diversification	diversification	NN
cord-306921-3afgpunj	65	17	pattern	pattern	NN
cord-306921-3afgpunj	65	18	for	for	IN
cord-306921-3afgpunj	65	19	this	this	DT
cord-306921-3afgpunj	65	20	virus	virus	NN
cord-306921-3afgpunj	65	21	[	[	-LRB-
cord-306921-3afgpunj	65	22	41	41	CD
cord-306921-3afgpunj	65	23	]	]	-RRB-
cord-306921-3afgpunj	65	24	.	.	.
cord-306921-3afgpunj	66	1	The	the	DT
cord-306921-3afgpunj	66	2	establishment	establishment	NN
cord-306921-3afgpunj	66	3	of	of	IN
cord-306921-3afgpunj	66	4	an	an	DT
cord-306921-3afgpunj	66	5	experimental	experimental	JJ
cord-306921-3afgpunj	66	6	mouse	mouse	NN
cord-306921-3afgpunj	66	7	model	model	NN
cord-306921-3afgpunj	66	8	by	by	IN
cord-306921-3afgpunj	66	9	Hixon	Hixon	NNP
cord-306921-3afgpunj	66	10	and	and	CC
cord-306921-3afgpunj	66	11	colleagues	colleague	NNS
cord-306921-3afgpunj	66	12	for	for	IN
cord-306921-3afgpunj	66	13	studying	study	VBG
cord-306921-3afgpunj	66	14	the	the	DT
cord-306921-3afgpunj	66	15	effects	effect	NNS
cord-306921-3afgpunj	66	16	of	of	IN
cord-306921-3afgpunj	66	17	EV	EV	NNP
cord-306921-3afgpunj	66	18	-	-	HYPH
cord-306921-3afgpunj	66	19	D68	D68	NNP
cord-306921-3afgpunj	66	20	provides	provide	VBZ
cord-306921-3afgpunj	66	21	much	much	JJ
cord-306921-3afgpunj	66	22	needed	need	VBN
cord-306921-3afgpunj	66	23	animal	animal	NN
cord-306921-3afgpunj	66	24	model	model	NN
cord-306921-3afgpunj	66	25	for	for	IN
cord-306921-3afgpunj	66	26	better	well	JJR
cord-306921-3afgpunj	66	27	understanding	understanding	NN
cord-306921-3afgpunj	66	28	of	of	IN
cord-306921-3afgpunj	66	29	the	the	DT
cord-306921-3afgpunj	66	30	infection	infection	NN
cord-306921-3afgpunj	66	31	cycle	cycle	NN
cord-306921-3afgpunj	66	32	of	of	IN
cord-306921-3afgpunj	66	33	this	this	DT
cord-306921-3afgpunj	66	34	virus	virus	NN
cord-306921-3afgpunj	66	35	[	[	-LRB-
cord-306921-3afgpunj	66	36	42	42	CD
cord-306921-3afgpunj	66	37	]	]	-RRB-
cord-306921-3afgpunj	66	38	.	.	.
cord-306921-3afgpunj	67	1	Establishing	establish	VBG
cord-306921-3afgpunj	67	2	the	the	DT
cord-306921-3afgpunj	67	3	EV	EV	NNP
cord-306921-3afgpunj	67	4	-	-	HYPH
cord-306921-3afgpunj	67	5	D68	D68	NNP
cord-306921-3afgpunj	67	6	human	human	JJ
cord-306921-3afgpunj	67	7	host	host	NN
cord-306921-3afgpunj	67	8	cell	cell	NN
cord-306921-3afgpunj	67	9	interactions	interaction	NNS
cord-306921-3afgpunj	67	10	will	will	MD
cord-306921-3afgpunj	67	11	provide	provide	VB
cord-306921-3afgpunj	67	12	an	an	DT
cord-306921-3afgpunj	67	13	insight	insight	NN
cord-306921-3afgpunj	67	14	into	into	IN
cord-306921-3afgpunj	67	15	the	the	DT
cord-306921-3afgpunj	67	16	pathogenesis	pathogenesis	NN
cord-306921-3afgpunj	67	17	of	of	IN
cord-306921-3afgpunj	67	18	the	the	DT
cord-306921-3afgpunj	67	19	infection	infection	NN
cord-306921-3afgpunj	67	20	and	and	CC
cord-306921-3afgpunj	67	21	eventually	eventually	RB
cord-306921-3afgpunj	67	22	be	be	VB
cord-306921-3afgpunj	67	23	vital	vital	JJ
cord-306921-3afgpunj	67	24	in	in	IN
cord-306921-3afgpunj	67	25	the	the	DT
cord-306921-3afgpunj	67	26	design	design	NN
cord-306921-3afgpunj	67	27	of	of	IN
cord-306921-3afgpunj	67	28	antivirals	antiviral	NNS
cord-306921-3afgpunj	67	29	and	and	CC
cord-306921-3afgpunj	67	30	vaccines	vaccine	NNS
cord-306921-3afgpunj	67	31	against	against	IN
cord-306921-3afgpunj	67	32	the	the	DT
cord-306921-3afgpunj	67	33	virus	virus	NN
cord-306921-3afgpunj	67	34	.	.	.
cord-306921-3afgpunj	68	1	There	there	EX
cord-306921-3afgpunj	68	2	is	be	VBZ
cord-306921-3afgpunj	68	3	necessity	necessity	NN
cord-306921-3afgpunj	68	4	to	to	TO
cord-306921-3afgpunj	68	5	extensively	extensively	RB
cord-306921-3afgpunj	68	6	understand	understand	VB
cord-306921-3afgpunj	68	7	the	the	DT
cord-306921-3afgpunj	68	8	molecular	molecular	JJ
cord-306921-3afgpunj	68	9	mechanisms	mechanism	NNS
cord-306921-3afgpunj	68	10	of	of	IN
cord-306921-3afgpunj	68	11	these	these	DT
cord-306921-3afgpunj	68	12	viruses	virus	NNS
cord-306921-3afgpunj	68	13	including	include	VBG
cord-306921-3afgpunj	68	14	the	the	DT
cord-306921-3afgpunj	68	15	infection	infection	NN
cord-306921-3afgpunj	68	16	paradigms	paradigm	NNS
cord-306921-3afgpunj	68	17	which	which	WDT
cord-306921-3afgpunj	68	18	will	will	MD
cord-306921-3afgpunj	68	19	be	be	VB
cord-306921-3afgpunj	68	20	key	key	JJ
cord-306921-3afgpunj	68	21	in	in	IN
cord-306921-3afgpunj	68	22	the	the	DT
cord-306921-3afgpunj	68	23	development	development	NN
cord-306921-3afgpunj	68	24	of	of	IN
cord-306921-3afgpunj	68	25	vaccines	vaccine	NNS
cord-306921-3afgpunj	68	26	and	and	CC
cord-306921-3afgpunj	68	27	antiviral	antiviral	JJ
cord-306921-3afgpunj	68	28	therapy	therapy	NN
cord-306921-3afgpunj	68	29	as	as	RB
cord-306921-3afgpunj	68	30	well	well	RB
cord-306921-3afgpunj	68	31	as	as	IN
cord-306921-3afgpunj	68	32	players	player	NNS
cord-306921-3afgpunj	68	33	in	in	IN
cord-306921-3afgpunj	68	34	molecular	molecular	JJ
cord-306921-3afgpunj	68	35	epidemiology	epidemiology	NN
cord-306921-3afgpunj	68	36	.	.	.
cord-306921-3afgpunj	69	1	Host	host	NN
cord-306921-3afgpunj	69	2	factors	factor	NNS
cord-306921-3afgpunj	69	3	/	/	SYM
cord-306921-3afgpunj	69	4	processes	process	NNS
cord-306921-3afgpunj	69	5	involved	involve	VBN
cord-306921-3afgpunj	69	6	in	in	IN
cord-306921-3afgpunj	69	7	NPEV	NPEV	NNP
cord-306921-3afgpunj	69	8	attachment	attachment	NN
cord-306921-3afgpunj	69	9	,	,	,
cord-306921-3afgpunj	69	10	entry	entry	NN
cord-306921-3afgpunj	69	11	and	and	CC
cord-306921-3afgpunj	69	12	internalizatione	internalizatione	NN
cord-306921-3afgpunj	69	13	Viral	viral	JJ
cord-306921-3afgpunj	69	14	tissue	tissue	NN
cord-306921-3afgpunj	69	15	tropism	tropism	NN
cord-306921-3afgpunj	69	16	depends	depend	VBZ
cord-306921-3afgpunj	69	17	solely	solely	RB
cord-306921-3afgpunj	69	18	on	on	IN
cord-306921-3afgpunj	69	19	cellular	cellular	JJ
cord-306921-3afgpunj	69	20	receptors	receptor	NNS
cord-306921-3afgpunj	69	21	which	which	WDT
cord-306921-3afgpunj	69	22	are	be	VBP
cord-306921-3afgpunj	69	23	responsible	responsible	JJ
cord-306921-3afgpunj	69	24	for	for	IN
cord-306921-3afgpunj	69	25	attachment	attachment	NN
cord-306921-3afgpunj	69	26	and	and	CC
cord-306921-3afgpunj	69	27	entry	entry	NN
cord-306921-3afgpunj	69	28	of	of	IN
cord-306921-3afgpunj	69	29	the	the	DT
cord-306921-3afgpunj	69	30	virus	virus	NN
cord-306921-3afgpunj	69	31	particles	particle	NNS
cord-306921-3afgpunj	69	32	into	into	IN
cord-306921-3afgpunj	69	33	the	the	DT
cord-306921-3afgpunj	69	34	host	host	NN
cord-306921-3afgpunj	69	35	cells	cell	NNS
cord-306921-3afgpunj	69	36	.	.	.
cord-306921-3afgpunj	70	1	Human	human	JJ
cord-306921-3afgpunj	70	2	host	host	NN
cord-306921-3afgpunj	70	3	proteins	protein	NNS
cord-306921-3afgpunj	70	4	act	act	VBP
cord-306921-3afgpunj	70	5	as	as	IN
cord-306921-3afgpunj	70	6	receptors	receptor	NNS
cord-306921-3afgpunj	70	7	for	for	IN
cord-306921-3afgpunj	70	8	viral	viral	JJ
cord-306921-3afgpunj	70	9	attachment	attachment	NN
cord-306921-3afgpunj	70	10	and	and	CC
cord-306921-3afgpunj	70	11	eventual	eventual	JJ
cord-306921-3afgpunj	70	12	entry	entry	NN
cord-306921-3afgpunj	70	13	into	into	IN
cord-306921-3afgpunj	70	14	the	the	DT
cord-306921-3afgpunj	70	15	cells	cell	NNS
cord-306921-3afgpunj	70	16	playing	play	VBG
cord-306921-3afgpunj	70	17	a	a	DT
cord-306921-3afgpunj	70	18	role	role	NN
cord-306921-3afgpunj	70	19	in	in	IN
cord-306921-3afgpunj	70	20	the	the	DT
cord-306921-3afgpunj	70	21	tissue	tissue	NN
cord-306921-3afgpunj	70	22	tropism	tropism	NN
cord-306921-3afgpunj	70	23	for	for	IN
cord-306921-3afgpunj	70	24	various	various	JJ
cord-306921-3afgpunj	70	25	viral	viral	JJ
cord-306921-3afgpunj	70	26	infections	infection	NNS
cord-306921-3afgpunj	70	27	.	.	.
cord-306921-3afgpunj	71	1	Several	several	JJ
cord-306921-3afgpunj	71	2	receptors	receptor	NNS
cord-306921-3afgpunj	71	3	have	have	VBP
cord-306921-3afgpunj	71	4	been	be	VBN
cord-306921-3afgpunj	71	5	identified	identify	VBN
cord-306921-3afgpunj	71	6	for	for	IN
cord-306921-3afgpunj	71	7	various	various	JJ
cord-306921-3afgpunj	71	8	picornaviruses	picornavirus	NNS
cord-306921-3afgpunj	71	9	with	with	IN
cord-306921-3afgpunj	71	10	poliovirus	poliovirus	NN
cord-306921-3afgpunj	71	11	receptors	receptor	NNS
cord-306921-3afgpunj	71	12	being	be	VBG
cord-306921-3afgpunj	71	13	the	the	DT
cord-306921-3afgpunj	71	14	first	first	JJ
cord-306921-3afgpunj	71	15	ones	one	NNS
cord-306921-3afgpunj	71	16	to	to	TO
cord-306921-3afgpunj	71	17	be	be	VB
cord-306921-3afgpunj	71	18	identified	identify	VBN
cord-306921-3afgpunj	71	19	in	in	IN
cord-306921-3afgpunj	71	20	this	this	DT
cord-306921-3afgpunj	71	21	family	family	NN
cord-306921-3afgpunj	71	22	.	.	.
cord-306921-3afgpunj	72	1	With	with	IN
cord-306921-3afgpunj	72	2	the	the	DT
cord-306921-3afgpunj	72	3	recent	recent	JJ
cord-306921-3afgpunj	72	4	reemergence	reemergence	NN
cord-306921-3afgpunj	72	5	of	of	IN
cord-306921-3afgpunj	72	6	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	72	7	infection	infection	NN
cord-306921-3afgpunj	72	8	outbreaks	outbreak	NNS
cord-306921-3afgpunj	72	9	,	,	,
cord-306921-3afgpunj	72	10	there	there	EX
cord-306921-3afgpunj	72	11	is	be	VBZ
cord-306921-3afgpunj	72	12	need	need	NN
cord-306921-3afgpunj	72	13	to	to	TO
cord-306921-3afgpunj	72	14	document	document	VB
cord-306921-3afgpunj	72	15	all	all	PDT
cord-306921-3afgpunj	72	16	the	the	DT
cord-306921-3afgpunj	72	17	recent	recent	JJ
cord-306921-3afgpunj	72	18	findings	finding	NNS
cord-306921-3afgpunj	72	19	in	in	IN
cord-306921-3afgpunj	72	20	the	the	DT
cord-306921-3afgpunj	72	21	entry	entry	NN
cord-306921-3afgpunj	72	22	process	process	NN
cord-306921-3afgpunj	72	23	of	of	IN
cord-306921-3afgpunj	72	24	these	these	DT
cord-306921-3afgpunj	72	25	viruses	virus	NNS
cord-306921-3afgpunj	72	26	;	;	:
cord-306921-3afgpunj	72	27	pointing	point	VBG
cord-306921-3afgpunj	72	28	to	to	IN
cord-306921-3afgpunj	72	29	the	the	DT
cord-306921-3afgpunj	72	30	eventual	eventual	JJ
cord-306921-3afgpunj	72	31	gaps	gap	NNS
cord-306921-3afgpunj	72	32	that	that	WDT
cord-306921-3afgpunj	72	33	needs	need	VBZ
cord-306921-3afgpunj	72	34	further	further	JJ
cord-306921-3afgpunj	72	35	research	research	NN
cord-306921-3afgpunj	72	36	.	.	.
cord-306921-3afgpunj	73	1	Interplay	interplay	NN
cord-306921-3afgpunj	73	2	between	between	IN
cord-306921-3afgpunj	73	3	viral	viral	JJ
cord-306921-3afgpunj	73	4	proteins	protein	NNS
cord-306921-3afgpunj	73	5	and	and	CC
cord-306921-3afgpunj	73	6	human	human	JJ
cord-306921-3afgpunj	73	7	host	host	NN
cord-306921-3afgpunj	73	8	proteins	protein	NNS
cord-306921-3afgpunj	73	9	play	play	VBP
cord-306921-3afgpunj	73	10	a	a	DT
cord-306921-3afgpunj	73	11	major	major	JJ
cord-306921-3afgpunj	73	12	role	role	NN
cord-306921-3afgpunj	73	13	in	in	IN
cord-306921-3afgpunj	73	14	the	the	DT
cord-306921-3afgpunj	73	15	attachment	attachment	NN
cord-306921-3afgpunj	73	16	,	,	,
cord-306921-3afgpunj	73	17	entry	entry	NN
cord-306921-3afgpunj	73	18	and	and	CC
cord-306921-3afgpunj	73	19	internalization	internalization	NN
cord-306921-3afgpunj	73	20	of	of	IN
cord-306921-3afgpunj	73	21	viral	viral	JJ
cord-306921-3afgpunj	73	22	infections	infection	NNS
cord-306921-3afgpunj	73	23	.	.	.
cord-306921-3afgpunj	74	1	Specific	specific	JJ
cord-306921-3afgpunj	74	2	viruses	virus	NNS
cord-306921-3afgpunj	74	3	use	use	VBP
cord-306921-3afgpunj	74	4	a	a	DT
cord-306921-3afgpunj	74	5	confined	confine	VBN
cord-306921-3afgpunj	74	6	set	set	NN
cord-306921-3afgpunj	74	7	of	of	IN
cord-306921-3afgpunj	74	8	receptors	receptor	NNS
cord-306921-3afgpunj	74	9	on	on	IN
cord-306921-3afgpunj	74	10	the	the	DT
cord-306921-3afgpunj	74	11	cell	cell	NN
cord-306921-3afgpunj	74	12	membrane	membrane	NN
cord-306921-3afgpunj	74	13	for	for	IN
cord-306921-3afgpunj	74	14	entry	entry	NN
cord-306921-3afgpunj	74	15	into	into	IN
cord-306921-3afgpunj	74	16	susceptible	susceptible	JJ
cord-306921-3afgpunj	74	17	cells	cell	NNS
cord-306921-3afgpunj	74	18	,	,	,
cord-306921-3afgpunj	74	19	eventual	eventual	JJ
cord-306921-3afgpunj	74	20	uncoating	uncoating	NN
cord-306921-3afgpunj	74	21	of	of	IN
cord-306921-3afgpunj	74	22	the	the	DT
cord-306921-3afgpunj	74	23	virus	virus	NN
cord-306921-3afgpunj	74	24	.	.	.
cord-306921-3afgpunj	75	1	This	this	DT
cord-306921-3afgpunj	75	2	process	process	NN
cord-306921-3afgpunj	75	3	is	be	VBZ
cord-306921-3afgpunj	75	4	vital	vital	JJ
cord-306921-3afgpunj	75	5	for	for	IN
cord-306921-3afgpunj	75	6	the	the	DT
cord-306921-3afgpunj	75	7	eventual	eventual	JJ
cord-306921-3afgpunj	75	8	reproduction	reproduction	NN
cord-306921-3afgpunj	75	9	of	of	IN
cord-306921-3afgpunj	75	10	viral	viral	JJ
cord-306921-3afgpunj	75	11	genome	genome	NN
cord-306921-3afgpunj	75	12	and	and	CC
cord-306921-3afgpunj	75	13	for	for	IN
cord-306921-3afgpunj	75	14	continuity	continuity	NN
cord-306921-3afgpunj	75	15	of	of	IN
cord-306921-3afgpunj	75	16	the	the	DT
cord-306921-3afgpunj	75	17	viral	viral	JJ
cord-306921-3afgpunj	75	18	life	life	NN
cord-306921-3afgpunj	75	19	cycle	cycle	NN
cord-306921-3afgpunj	75	20	.	.	.
cord-306921-3afgpunj	76	1	Among	among	IN
cord-306921-3afgpunj	76	2	the	the	DT
cord-306921-3afgpunj	76	3	picornaviruses	picornavirus	NNS
cord-306921-3afgpunj	76	4	,	,	,
cord-306921-3afgpunj	76	5	poliovirus	poliovirus	NN
cord-306921-3afgpunj	76	6	is	be	VBZ
cord-306921-3afgpunj	76	7	the	the	DT
cord-306921-3afgpunj	76	8	most	most	RBS
cord-306921-3afgpunj	76	9	extensively	extensively	RB
cord-306921-3afgpunj	76	10	studied	study	VBN
cord-306921-3afgpunj	76	11	and	and	CC
cord-306921-3afgpunj	76	12	several	several	JJ
cord-306921-3afgpunj	76	13	studies	study	NNS
cord-306921-3afgpunj	76	14	on	on	IN
cord-306921-3afgpunj	76	15	non	non	JJ
cord-306921-3afgpunj	76	16	-	-	JJ
cord-306921-3afgpunj	76	17	polio	polio	JJ
cord-306921-3afgpunj	76	18	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	76	19	have	have	VBP
cord-306921-3afgpunj	76	20	relied	rely	VBN
cord-306921-3afgpunj	76	21	on	on	IN
cord-306921-3afgpunj	76	22	these	these	DT
cord-306921-3afgpunj	76	23	studies	study	NNS
cord-306921-3afgpunj	76	24	.	.	.
cord-306921-3afgpunj	77	1	A	a	DT
cord-306921-3afgpunj	77	2	few	few	JJ
cord-306921-3afgpunj	77	3	host	host	NN
cord-306921-3afgpunj	77	4	factors	factor	NNS
cord-306921-3afgpunj	77	5	have	have	VBP
cord-306921-3afgpunj	77	6	been	be	VBN
cord-306921-3afgpunj	77	7	identified	identify	VBN
cord-306921-3afgpunj	77	8	as	as	IN
cord-306921-3afgpunj	77	9	possible	possible	JJ
cord-306921-3afgpunj	77	10	receptors	receptor	NNS
cord-306921-3afgpunj	77	11	for	for	IN
cord-306921-3afgpunj	77	12	the	the	DT
cord-306921-3afgpunj	77	13	NPEVs	npev	NNS
cord-306921-3afgpunj	77	14	,	,	,
cord-306921-3afgpunj	77	15	but	but	CC
cord-306921-3afgpunj	77	16	the	the	DT
cord-306921-3afgpunj	77	17	dynamics	dynamic	NNS
cord-306921-3afgpunj	77	18	of	of	IN
cord-306921-3afgpunj	77	19	the	the	DT
cord-306921-3afgpunj	77	20	eventual	eventual	JJ
cord-306921-3afgpunj	77	21	attachment	attachment	NN
cord-306921-3afgpunj	77	22	,	,	,
cord-306921-3afgpunj	77	23	entry	entry	NN
cord-306921-3afgpunj	77	24	and	and	CC
cord-306921-3afgpunj	77	25	internalization	internalization	NN
cord-306921-3afgpunj	77	26	is	be	VBZ
cord-306921-3afgpunj	77	27	not	not	RB
cord-306921-3afgpunj	77	28	yet	yet	RB
cord-306921-3afgpunj	77	29	fully	fully	RB
cord-306921-3afgpunj	77	30	understood	understand	VBN
cord-306921-3afgpunj	77	31	.	.	.
cord-306921-3afgpunj	78	1	Clathrin	Clathrin	NNP
cord-306921-3afgpunj	78	2	-	-	HYPH
cord-306921-3afgpunj	78	3	mediated	mediate	VBN
cord-306921-3afgpunj	78	4	endocytosis	endocytosis	NN
cord-306921-3afgpunj	78	5	as	as	IN
cord-306921-3afgpunj	78	6	an	an	DT
cord-306921-3afgpunj	78	7	entry	entry	NN
cord-306921-3afgpunj	78	8	pathway	pathway	NN
cord-306921-3afgpunj	78	9	for	for	IN
cord-306921-3afgpunj	78	10	EV	EV	NNP
cord-306921-3afgpunj	78	11	-	-	HYPH
cord-306921-3afgpunj	78	12	A71	A71	NNP
cord-306921-3afgpunj	78	13	virus	virus	NN
cord-306921-3afgpunj	78	14	was	be	VBD
cord-306921-3afgpunj	78	15	identified	identify	VBN
cord-306921-3afgpunj	78	16	through	through	IN
cord-306921-3afgpunj	78	17	siRNA	siRNA	NNP
cord-306921-3afgpunj	78	18	screens	screen	NNS
cord-306921-3afgpunj	78	19	targeting	target	VBG
cord-306921-3afgpunj	78	20	key	key	JJ
cord-306921-3afgpunj	78	21	genes	gene	NNS
cord-306921-3afgpunj	78	22	involved	involve	VBN
cord-306921-3afgpunj	78	23	in	in	IN
cord-306921-3afgpunj	78	24	the	the	DT
cord-306921-3afgpunj	78	25	process	process	NN
cord-306921-3afgpunj	78	26	of	of	IN
cord-306921-3afgpunj	78	27	endocytosis	endocytosis	NN
cord-306921-3afgpunj	78	28	cytoskeletal	cytoskeletal	JJ
cord-306921-3afgpunj	78	29	dynamics	dynamic	NNS
cord-306921-3afgpunj	78	30	,	,	,
cord-306921-3afgpunj	78	31	and	and	CC
cord-306921-3afgpunj	78	32	endosomal	endosomal	NNP
cord-306921-3afgpunj	78	33	trafficking	traffic	VBG
cord-306921-3afgpunj	78	34	[	[	-LRB-
cord-306921-3afgpunj	78	35	43	43	CD
cord-306921-3afgpunj	78	36	,	,	,
cord-306921-3afgpunj	78	37	44	44	CD
cord-306921-3afgpunj	78	38	]	]	-RRB-
cord-306921-3afgpunj	78	39	.	.	.
cord-306921-3afgpunj	79	1	Since	since	IN
cord-306921-3afgpunj	79	2	then	then	RB
cord-306921-3afgpunj	79	3	it	-PRON-	PRP
cord-306921-3afgpunj	79	4	has	have	VBZ
cord-306921-3afgpunj	79	5	always	always	RB
cord-306921-3afgpunj	79	6	been	be	VBN
cord-306921-3afgpunj	79	7	known	know	VBN
cord-306921-3afgpunj	79	8	that	that	IN
cord-306921-3afgpunj	79	9	clathrin	clathrin	NN
cord-306921-3afgpunj	79	10	mediated	mediate	VBN
cord-306921-3afgpunj	79	11	endocytosis	endocytosis	NN
cord-306921-3afgpunj	79	12	is	be	VBZ
cord-306921-3afgpunj	79	13	the	the	DT
cord-306921-3afgpunj	79	14	major	major	JJ
cord-306921-3afgpunj	79	15	route	route	NN
cord-306921-3afgpunj	79	16	of	of	IN
cord-306921-3afgpunj	79	17	EV	EV	NNP
cord-306921-3afgpunj	79	18	-	-	HYPH
cord-306921-3afgpunj	79	19	A71	A71	NNP
cord-306921-3afgpunj	79	20	entry	entry	NN
cord-306921-3afgpunj	79	21	into	into	IN
cord-306921-3afgpunj	79	22	susceptible	susceptible	JJ
cord-306921-3afgpunj	79	23	cells	cell	NNS
cord-306921-3afgpunj	79	24	.	.	.
cord-306921-3afgpunj	80	1	However	however	RB
cord-306921-3afgpunj	80	2	,	,	,
cord-306921-3afgpunj	80	3	inhibition	inhibition	NN
cord-306921-3afgpunj	80	4	of	of	IN
cord-306921-3afgpunj	80	5	the	the	DT
cord-306921-3afgpunj	80	6	clathrinmediated	clathrinmediate	VBN
cord-306921-3afgpunj	80	7	endocytosis	endocytosis	NN
cord-306921-3afgpunj	80	8	pathways	pathway	NNS
cord-306921-3afgpunj	80	9	by	by	IN
cord-306921-3afgpunj	80	10	chlorpromazine	chlorpromazine	NN
cord-306921-3afgpunj	80	11	(	(	-LRB-
cord-306921-3afgpunj	80	12	CPZ	CPZ	NNP
cord-306921-3afgpunj	80	13	)	)	-RRB-
cord-306921-3afgpunj	80	14	or	or	CC
cord-306921-3afgpunj	80	15	dynasore	dynasore	JJ
cord-306921-3afgpunj	80	16	(	(	-LRB-
cord-306921-3afgpunj	80	17	DNS	DNS	NNP
cord-306921-3afgpunj	80	18	)	)	-RRB-
cord-306921-3afgpunj	80	19	did	do	VBD
cord-306921-3afgpunj	80	20	not	not	RB
cord-306921-3afgpunj	80	21	inhibit	inhibit	VB
cord-306921-3afgpunj	80	22	EV	EV	NNP
cord-306921-3afgpunj	80	23	-	-	HYPH
cord-306921-3afgpunj	80	24	A71	A71	NNP
cord-306921-3afgpunj	80	25	entry	entry	NN
cord-306921-3afgpunj	80	26	into	into	IN
cord-306921-3afgpunj	80	27	the	the	DT
cord-306921-3afgpunj	80	28	A549	A549	NNP
cord-306921-3afgpunj	80	29	cells	cell	NNS
cord-306921-3afgpunj	80	30	,	,	,
cord-306921-3afgpunj	80	31	thus	thus	RB
cord-306921-3afgpunj	80	32	pointing	point	VBG
cord-306921-3afgpunj	80	33	to	to	IN
cord-306921-3afgpunj	80	34	a	a	DT
cord-306921-3afgpunj	80	35	combination	combination	NN
cord-306921-3afgpunj	80	36	of	of	IN
cord-306921-3afgpunj	80	37	pathways	pathway	NNS
cord-306921-3afgpunj	80	38	involved	involve	VBN
cord-306921-3afgpunj	80	39	in	in	IN
cord-306921-3afgpunj	80	40	the	the	DT
cord-306921-3afgpunj	80	41	viral	viral	JJ
cord-306921-3afgpunj	80	42	entry	entry	NN
cord-306921-3afgpunj	80	43	[	[	-LRB-
cord-306921-3afgpunj	80	44	45	45	CD
cord-306921-3afgpunj	80	45	]	]	-RRB-
cord-306921-3afgpunj	80	46	.	.	.
cord-306921-3afgpunj	81	1	Among	among	IN
cord-306921-3afgpunj	81	2	the	the	DT
cord-306921-3afgpunj	81	3	picornaviruses	picornavirus	NNS
cord-306921-3afgpunj	81	4	,	,	,
cord-306921-3afgpunj	81	5	poliovirus	poliovirus	NN
cord-306921-3afgpunj	81	6	and	and	CC
cord-306921-3afgpunj	81	7	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	81	8	receptors	receptor	NNS
cord-306921-3afgpunj	81	9	were	be	VBD
cord-306921-3afgpunj	81	10	identified	identify	VBN
cord-306921-3afgpunj	81	11	in	in	IN
cord-306921-3afgpunj	81	12	1989	1989	CD
cord-306921-3afgpunj	81	13	;	;	:
cord-306921-3afgpunj	81	14	being	be	VBG
cord-306921-3afgpunj	81	15	the	the	DT
cord-306921-3afgpunj	81	16	first	first	JJ
cord-306921-3afgpunj	81	17	enterovirus	enterovirus	NN
cord-306921-3afgpunj	81	18	receptors	receptor	NNS
cord-306921-3afgpunj	81	19	to	to	TO
cord-306921-3afgpunj	81	20	be	be	VB
cord-306921-3afgpunj	81	21	described	describe	VBN
cord-306921-3afgpunj	81	22	.	.	.
cord-306921-3afgpunj	82	1	Greve	Greve	NNP
cord-306921-3afgpunj	82	2	and	and	CC
cord-306921-3afgpunj	82	3	his	-PRON-	PRP$
cord-306921-3afgpunj	82	4	colleagues	colleague	NNS
cord-306921-3afgpunj	82	5	identified	identify	VBD
cord-306921-3afgpunj	82	6	intercellular	intercellular	JJ
cord-306921-3afgpunj	82	7	adhesion	adhesion	NN
cord-306921-3afgpunj	82	8	molecule	molecule	NN
cord-306921-3afgpunj	82	9	1	1	CD
cord-306921-3afgpunj	82	10	(	(	-LRB-
cord-306921-3afgpunj	82	11	ICAM-1	ICAM-1	NNP
cord-306921-3afgpunj	82	12	)	)	-RRB-
cord-306921-3afgpunj	82	13	as	as	IN
cord-306921-3afgpunj	82	14	a	a	DT
cord-306921-3afgpunj	82	15	Rhinovirus	Rhinovirus	NNP
cord-306921-3afgpunj	82	16	receptor	receptor	NN
cord-306921-3afgpunj	82	17	[	[	-LRB-
cord-306921-3afgpunj	82	18	46	46	CD
cord-306921-3afgpunj	82	19	]	]	-RRB-
cord-306921-3afgpunj	82	20	while	while	IN
cord-306921-3afgpunj	82	21	CD155	CD155	NNP
cord-306921-3afgpunj	82	22	was	be	VBD
cord-306921-3afgpunj	82	23	described	describe	VBN
cord-306921-3afgpunj	82	24	as	as	IN
cord-306921-3afgpunj	82	25	a	a	DT
cord-306921-3afgpunj	82	26	poliovirus	poliovirus	NN
cord-306921-3afgpunj	82	27	receptor	receptor	NN
cord-306921-3afgpunj	82	28	by	by	IN
cord-306921-3afgpunj	82	29	Mendelshon	Mendelshon	NNP
cord-306921-3afgpunj	82	30	and	and	CC
cord-306921-3afgpunj	82	31	colleagues	colleague	NNS
cord-306921-3afgpunj	82	32	[	[	-LRB-
cord-306921-3afgpunj	82	33	47	47	CD
cord-306921-3afgpunj	82	34	]	]	-RRB-
cord-306921-3afgpunj	82	35	.	.	.
cord-306921-3afgpunj	83	1	Some	some	DT
cord-306921-3afgpunj	83	2	EV	EV	NNP
cord-306921-3afgpunj	83	3	-	-	HYPH
cord-306921-3afgpunj	83	4	A71	A71	NNP
cord-306921-3afgpunj	83	5	receptors	receptor	NNS
cord-306921-3afgpunj	83	6	have	have	VBP
cord-306921-3afgpunj	83	7	been	be	VBN
cord-306921-3afgpunj	83	8	identified	identify	VBN
cord-306921-3afgpunj	83	9	;	;	:
cord-306921-3afgpunj	83	10	but	but	CC
cord-306921-3afgpunj	83	11	these	these	DT
cord-306921-3afgpunj	83	12	putative	putative	JJ
cord-306921-3afgpunj	83	13	receptors	receptor	NNS
cord-306921-3afgpunj	83	14	have	have	VBP
cord-306921-3afgpunj	83	15	not	not	RB
cord-306921-3afgpunj	83	16	been	be	VBN
cord-306921-3afgpunj	83	17	able	able	JJ
cord-306921-3afgpunj	83	18	to	to	TO
cord-306921-3afgpunj	83	19	fully	fully	RB
cord-306921-3afgpunj	83	20	explain	explain	VB
cord-306921-3afgpunj	83	21	the	the	DT
cord-306921-3afgpunj	83	22	diverse	diverse	JJ
cord-306921-3afgpunj	83	23	nature	nature	NN
cord-306921-3afgpunj	83	24	of	of	IN
cord-306921-3afgpunj	83	25	symptoms	symptom	NNS
cord-306921-3afgpunj	83	26	observed	observe	VBN
cord-306921-3afgpunj	83	27	in	in	IN
cord-306921-3afgpunj	83	28	hand	hand	NN
cord-306921-3afgpunj	83	29	,	,	,
cord-306921-3afgpunj	83	30	foot	foot	NN
cord-306921-3afgpunj	83	31	and	and	CC
cord-306921-3afgpunj	83	32	mouth	mouth	NN
cord-306921-3afgpunj	83	33	disease	disease	NN
cord-306921-3afgpunj	83	34	cases	case	NNS
cord-306921-3afgpunj	83	35	.	.	.
cord-306921-3afgpunj	84	1	EV	EV	NNP
cord-306921-3afgpunj	84	2	-	-	HYPH
cord-306921-3afgpunj	84	3	A71	A71	NNP
cord-306921-3afgpunj	84	4	receptors	receptor	NNS
cord-306921-3afgpunj	84	5	include	include	VBP
cord-306921-3afgpunj	84	6	;	;	:
cord-306921-3afgpunj	84	7	human	human	JJ
cord-306921-3afgpunj	84	8	scavenger	scavenger	NN
cord-306921-3afgpunj	84	9	receptor	receptor	NN
cord-306921-3afgpunj	84	10	class	class	NN
cord-306921-3afgpunj	84	11	B	B	NNP
cord-306921-3afgpunj	84	12	member	member	NN
cord-306921-3afgpunj	84	13	2	2	CD
cord-306921-3afgpunj	84	14	(	(	-LRB-
cord-306921-3afgpunj	84	15	SCARB2	SCARB2	NNP
cord-306921-3afgpunj	84	16	)	)	-RRB-
cord-306921-3afgpunj	84	17	;	;	:
cord-306921-3afgpunj	84	18	a	a	DT
cord-306921-3afgpunj	84	19	known	know	VBN
cord-306921-3afgpunj	84	20	to	to	TO
cord-306921-3afgpunj	84	21	not	not	RB
cord-306921-3afgpunj	84	22	only	only	RB
cord-306921-3afgpunj	84	23	function	function	VB
cord-306921-3afgpunj	84	24	as	as	IN
cord-306921-3afgpunj	84	25	an	an	DT
cord-306921-3afgpunj	84	26	attachment	attachment	NN
cord-306921-3afgpunj	84	27	receptor	receptor	NN
cord-306921-3afgpunj	84	28	but	but	CC
cord-306921-3afgpunj	84	29	also	also	RB
cord-306921-3afgpunj	84	30	as	as	IN
cord-306921-3afgpunj	84	31	an	an	DT
cord-306921-3afgpunj	84	32	uncoating	uncoate	VBG
cord-306921-3afgpunj	84	33	receptor	receptor	NN
cord-306921-3afgpunj	84	34	during	during	IN
cord-306921-3afgpunj	84	35	EV	EV	NNP
cord-306921-3afgpunj	84	36	-	-	HYPH
cord-306921-3afgpunj	84	37	A71	A71	NNP
cord-306921-3afgpunj	84	38	infection	infection	NN
cord-306921-3afgpunj	84	39	[	[	-LRB-
cord-306921-3afgpunj	84	40	48	48	CD
cord-306921-3afgpunj	84	41	]	]	-RRB-
cord-306921-3afgpunj	84	42	.	.	.
cord-306921-3afgpunj	85	1	SCARB2	SCARB2	NNS
cord-306921-3afgpunj	86	1	receptor	receptor	NN
cord-306921-3afgpunj	86	2	is	be	VBZ
cord-306921-3afgpunj	86	3	ubiquitously	ubiquitously	RB
cord-306921-3afgpunj	86	4	expressed	express	VBN
cord-306921-3afgpunj	86	5	in	in	IN
cord-306921-3afgpunj	86	6	different	different	JJ
cord-306921-3afgpunj	86	7	parts	part	NNS
cord-306921-3afgpunj	86	8	of	of	IN
cord-306921-3afgpunj	86	9	the	the	DT
cord-306921-3afgpunj	86	10	body	body	NN
cord-306921-3afgpunj	86	11	including	include	VBG
cord-306921-3afgpunj	86	12	neuronal	neuronal	JJ
cord-306921-3afgpunj	86	13	cells	cell	NNS
cord-306921-3afgpunj	86	14	.	.	.
cord-306921-3afgpunj	87	1	SCARB2	SCARB2	NNP
cord-306921-3afgpunj	87	2	is	be	VBZ
cord-306921-3afgpunj	87	3	a	a	DT
cord-306921-3afgpunj	87	4	transmembrane	transmembrane	JJ
cord-306921-3afgpunj	87	5	receptor	receptor	NN
cord-306921-3afgpunj	87	6	and	and	CC
cord-306921-3afgpunj	87	7	a	a	DT
cord-306921-3afgpunj	87	8	known	know	VBN
cord-306921-3afgpunj	87	9	βglucocerebrosidase	βglucocerebrosidase	NN
cord-306921-3afgpunj	87	10	(	(	-LRB-
cord-306921-3afgpunj	87	11	β	β	NNP
cord-306921-3afgpunj	87	12	-	-	HYPH
cord-306921-3afgpunj	87	13	GC	GC	NNP
cord-306921-3afgpunj	87	14	)	)	-RRB-
cord-306921-3afgpunj	87	15	receptor	receptor	NN
cord-306921-3afgpunj	87	16	responsible	responsible	JJ
cord-306921-3afgpunj	87	17	for	for	IN
cord-306921-3afgpunj	87	18	transport	transport	NN
cord-306921-3afgpunj	87	19	from	from	IN
cord-306921-3afgpunj	87	20	endoplasmic	endoplasmic	NN
cord-306921-3afgpunj	87	21	reticulum	reticulum	NN
cord-306921-3afgpunj	87	22	to	to	IN
cord-306921-3afgpunj	87	23	lysosome	lysosome	NN
cord-306921-3afgpunj	87	24	and	and	CC
cord-306921-3afgpunj	87	25	is	be	VBZ
cord-306921-3afgpunj	87	26	also	also	RB
cord-306921-3afgpunj	87	27	key	key	JJ
cord-306921-3afgpunj	87	28	in	in	IN
cord-306921-3afgpunj	87	29	lysosome	lysosome	NN
cord-306921-3afgpunj	87	30	maintenance	maintenance	NN
cord-306921-3afgpunj	87	31	[	[	-LRB-
cord-306921-3afgpunj	87	32	49	49	CD
cord-306921-3afgpunj	87	33	]	]	-RRB-
cord-306921-3afgpunj	87	34	.	.	.
cord-306921-3afgpunj	88	1	SCARB2	SCARB2	NNS
cord-306921-3afgpunj	88	2	was	be	VBD
cord-306921-3afgpunj	88	3	also	also	RB
cord-306921-3afgpunj	88	4	identified	identify	VBN
cord-306921-3afgpunj	88	5	as	as	IN
cord-306921-3afgpunj	88	6	an	an	DT
cord-306921-3afgpunj	88	7	attachment	attachment	NN
cord-306921-3afgpunj	88	8	receptor	receptor	NN
cord-306921-3afgpunj	88	9	for	for	IN
cord-306921-3afgpunj	88	10	human	human	JJ
cord-306921-3afgpunj	88	11	enterovirus	enterovirus	NN
cord-306921-3afgpunj	88	12	species	species	VBP
cord-306921-3afgpunj	88	13	A	A	NNP
cord-306921-3afgpunj	88	14	and	and	CC
cord-306921-3afgpunj	89	1	coxsackie	coxsackie	NNP
cord-306921-3afgpunj	89	2	A	A	NNP
cord-306921-3afgpunj	89	3	16	16	CD
cord-306921-3afgpunj	89	4	virus	virus	NN
cord-306921-3afgpunj	89	5	[	[	-LRB-
cord-306921-3afgpunj	89	6	50	50	CD
cord-306921-3afgpunj	89	7	]	]	-RRB-
cord-306921-3afgpunj	89	8	.	.	.
cord-306921-3afgpunj	90	1	Several	several	JJ
cord-306921-3afgpunj	90	2	cell	cell	NN
cord-306921-3afgpunj	90	3	types	type	NNS
cord-306921-3afgpunj	90	4	are	be	VBP
cord-306921-3afgpunj	90	5	known	know	VBN
cord-306921-3afgpunj	90	6	to	to	TO
cord-306921-3afgpunj	90	7	express	express	VB
cord-306921-3afgpunj	90	8	SCARB2	SCARB2	NNS
cord-306921-3afgpunj	90	9	,	,	,
cord-306921-3afgpunj	90	10	including	include	VBG
cord-306921-3afgpunj	90	11	the	the	DT
cord-306921-3afgpunj	90	12	neurons	neuron	NNS
cord-306921-3afgpunj	90	13	thus	thus	RB
cord-306921-3afgpunj	90	14	may	may	MD
cord-306921-3afgpunj	90	15	be	be	VB
cord-306921-3afgpunj	90	16	directly	directly	RB
cord-306921-3afgpunj	90	17	linked	link	VBN
cord-306921-3afgpunj	90	18	to	to	IN
cord-306921-3afgpunj	90	19	the	the	DT
cord-306921-3afgpunj	90	20	neurological	neurological	JJ
cord-306921-3afgpunj	90	21	complications	complication	NNS
cord-306921-3afgpunj	90	22	associated	associate	VBN
cord-306921-3afgpunj	90	23	with	with	IN
cord-306921-3afgpunj	90	24	EV	EV	NNP
cord-306921-3afgpunj	90	25	-	-	HYPH
cord-306921-3afgpunj	90	26	A71	A71	NNP
cord-306921-3afgpunj	90	27	infections	infection	NNS
cord-306921-3afgpunj	90	28	;	;	:
cord-306921-3afgpunj	90	29	even	even	RB
cord-306921-3afgpunj	90	30	though	though	IN
cord-306921-3afgpunj	90	31	this	this	DT
cord-306921-3afgpunj	90	32	has	have	VBZ
cord-306921-3afgpunj	90	33	not	not	RB
cord-306921-3afgpunj	90	34	been	be	VBN
cord-306921-3afgpunj	90	35	validated	validate	VBN
cord-306921-3afgpunj	90	36	.	.	.
cord-306921-3afgpunj	91	1	At	at	IN
cord-306921-3afgpunj	91	2	acidic	acidic	JJ
cord-306921-3afgpunj	91	3	and	and	CC
cord-306921-3afgpunj	91	4	neutral	neutral	JJ
cord-306921-3afgpunj	91	5	conditions	condition	NNS
cord-306921-3afgpunj	91	6	,	,	,
cord-306921-3afgpunj	91	7	the	the	DT
cord-306921-3afgpunj	91	8	SCARB2	SCARB2	NNS
cord-306921-3afgpunj	91	9	undergoes	undergo	VBZ
cord-306921-3afgpunj	91	10	conformational	conformational	JJ
cord-306921-3afgpunj	91	11	changes	change	NNS
cord-306921-3afgpunj	91	12	leading	lead	VBG
cord-306921-3afgpunj	91	13	to	to	IN
cord-306921-3afgpunj	91	14	the	the	DT
cord-306921-3afgpunj	91	15	opening	opening	NN
cord-306921-3afgpunj	91	16	up	up	RP
cord-306921-3afgpunj	91	17	of	of	IN
cord-306921-3afgpunj	91	18	lipid	lipid	NN
cord-306921-3afgpunj	91	19	transfer	transfer	NN
cord-306921-3afgpunj	91	20	channel	channel	NN
cord-306921-3afgpunj	91	21	mediating	mediate	VBG
cord-306921-3afgpunj	91	22	ejection	ejection	NN
cord-306921-3afgpunj	91	23	of	of	IN
cord-306921-3afgpunj	91	24	hydrophobic	hydrophobic	JJ
cord-306921-3afgpunj	91	25	pocket	pocket	NN
cord-306921-3afgpunj	91	26	from	from	IN
cord-306921-3afgpunj	91	27	the	the	DT
cord-306921-3afgpunj	91	28	virion	virion	NN
cord-306921-3afgpunj	91	29	a	a	DT
cord-306921-3afgpunj	91	30	process	process	NN
cord-306921-3afgpunj	91	31	important	important	JJ
cord-306921-3afgpunj	91	32	for	for	IN
cord-306921-3afgpunj	91	33	viral	viral	JJ
cord-306921-3afgpunj	91	34	uncoating	uncoate	VBG
cord-306921-3afgpunj	91	35	[	[	-LRB-
cord-306921-3afgpunj	91	36	51	51	CD
cord-306921-3afgpunj	91	37	]	]	-RRB-
cord-306921-3afgpunj	91	38	.	.	.
cord-306921-3afgpunj	92	1	P	p	NN
cord-306921-3afgpunj	92	2	-	-	HYPH
cord-306921-3afgpunj	92	3	selectin	selectin	NN
cord-306921-3afgpunj	92	4	glycoprotein	glycoprotein	NN
cord-306921-3afgpunj	92	5	ligand-1	ligand-1	NNP
cord-306921-3afgpunj	92	6	(	(	-LRB-
cord-306921-3afgpunj	92	7	PSGL1	PSGL1	NNP
cord-306921-3afgpunj	92	8	)	)	-RRB-
cord-306921-3afgpunj	93	1	a	a	DT
cord-306921-3afgpunj	93	2	membrane	membrane	NN
cord-306921-3afgpunj	93	3	protein	protein	NN
cord-306921-3afgpunj	93	4	expressed	express	VBD
cord-306921-3afgpunj	93	5	on	on	IN
cord-306921-3afgpunj	93	6	white	white	JJ
cord-306921-3afgpunj	93	7	blood	blood	NN
cord-306921-3afgpunj	93	8	cells	cell	NNS
cord-306921-3afgpunj	93	9	where	where	WRB
cord-306921-3afgpunj	93	10	it	-PRON-	PRP
cord-306921-3afgpunj	93	11	is	be	VBZ
cord-306921-3afgpunj	93	12	responsible	responsible	JJ
cord-306921-3afgpunj	93	13	for	for	IN
cord-306921-3afgpunj	93	14	inflammation	inflammation	NN
cord-306921-3afgpunj	93	15	,	,	,
cord-306921-3afgpunj	93	16	tethering	tethering	NN
cord-306921-3afgpunj	93	17	or	or	CC
cord-306921-3afgpunj	93	18	rolling	rolling	NN
cord-306921-3afgpunj	93	19	of	of	IN
cord-306921-3afgpunj	93	20	leukocytes	leukocyte	NNS
cord-306921-3afgpunj	93	21	at	at	IN
cord-306921-3afgpunj	93	22	the	the	DT
cord-306921-3afgpunj	93	23	vascular	vascular	JJ
cord-306921-3afgpunj	93	24	endothelial	endothelial	NN
cord-306921-3afgpunj	93	25	has	have	VBZ
cord-306921-3afgpunj	93	26	also	also	RB
cord-306921-3afgpunj	93	27	been	be	VBN
cord-306921-3afgpunj	93	28	described	describe	VBN
cord-306921-3afgpunj	93	29	as	as	IN
cord-306921-3afgpunj	93	30	a	a	DT
cord-306921-3afgpunj	93	31	receptor	receptor	NN
cord-306921-3afgpunj	93	32	for	for	IN
cord-306921-3afgpunj	93	33	EV	EV	NNP
cord-306921-3afgpunj	93	34	-	-	HYPH
cord-306921-3afgpunj	93	35	A71	A71	NNP
cord-306921-3afgpunj	93	36	responsible	responsible	JJ
cord-306921-3afgpunj	93	37	for	for	IN
cord-306921-3afgpunj	93	38	the	the	DT
cord-306921-3afgpunj	93	39	viral	viral	JJ
cord-306921-3afgpunj	93	40	entry	entry	NN
cord-306921-3afgpunj	93	41	into	into	IN
cord-306921-3afgpunj	93	42	blood	blood	NN
cord-306921-3afgpunj	93	43	cells	cell	NNS
cord-306921-3afgpunj	93	44	[	[	-LRB-
cord-306921-3afgpunj	93	45	52	52	CD
cord-306921-3afgpunj	93	46	]	]	-RRB-
cord-306921-3afgpunj	94	1	[	[	-LRB-
cord-306921-3afgpunj	94	2	53	53	CD
cord-306921-3afgpunj	94	3	]	]	-RRB-
cord-306921-3afgpunj	94	4	[	[	-LRB-
cord-306921-3afgpunj	94	5	54	54	CD
cord-306921-3afgpunj	94	6	]	]	-RRB-
cord-306921-3afgpunj	94	7	.	.	.
cord-306921-3afgpunj	95	1	PSGL-1	PSGL-1	NNP
cord-306921-3afgpunj	95	2	has	have	VBZ
cord-306921-3afgpunj	95	3	a	a	DT
cord-306921-3afgpunj	95	4	high	high	JJ
cord-306921-3afgpunj	95	5	avidity	avidity	NN
cord-306921-3afgpunj	95	6	for	for	IN
cord-306921-3afgpunj	95	7	EV	EV	NNP
cord-306921-3afgpunj	95	8	-	-	HYPH
cord-306921-3afgpunj	95	9	A71	A71	NNP
cord-306921-3afgpunj	95	10	virus	virus	NN
cord-306921-3afgpunj	95	11	compared	compare	VBN
cord-306921-3afgpunj	95	12	to	to	IN
cord-306921-3afgpunj	95	13	SCARBR2	SCARBR2	NNP
cord-306921-3afgpunj	96	1	yet	yet	RB
cord-306921-3afgpunj	96	2	its	-PRON-	PRP$
cord-306921-3afgpunj	96	3	associated	associate	VBN
cord-306921-3afgpunj	96	4	with	with	IN
cord-306921-3afgpunj	96	5	low	low	JJ
cord-306921-3afgpunj	96	6	infection	infection	NN
cord-306921-3afgpunj	96	7	effeciency	effeciency	NN
cord-306921-3afgpunj	96	8	due	due	IN
cord-306921-3afgpunj	96	9	to	to	IN
cord-306921-3afgpunj	96	10	its	-PRON-	PRP$
cord-306921-3afgpunj	96	11	inability	inability	NN
cord-306921-3afgpunj	96	12	to	to	TO
cord-306921-3afgpunj	96	13	induce	induce	VB
cord-306921-3afgpunj	96	14	viral	viral	JJ
cord-306921-3afgpunj	96	15	uncoating	uncoate	VBG
cord-306921-3afgpunj	96	16	[	[	-LRB-
cord-306921-3afgpunj	96	17	55	55	CD
cord-306921-3afgpunj	96	18	]	]	-RRB-
cord-306921-3afgpunj	96	19	.	.	.
cord-306921-3afgpunj	97	1	Sialyated	sialyated	JJ
cord-306921-3afgpunj	97	2	glycans	glycan	NNS
cord-306921-3afgpunj	97	3	were	be	VBD
cord-306921-3afgpunj	97	4	also	also	RB
cord-306921-3afgpunj	97	5	elucidated	elucidate	VBN
cord-306921-3afgpunj	97	6	to	to	TO
cord-306921-3afgpunj	97	7	be	be	VB
cord-306921-3afgpunj	97	8	playing	play	VBG
cord-306921-3afgpunj	97	9	a	a	DT
cord-306921-3afgpunj	97	10	role	role	NN
cord-306921-3afgpunj	97	11	in	in	IN
cord-306921-3afgpunj	97	12	EV	EV	NNP
cord-306921-3afgpunj	97	13	-	-	HYPH
cord-306921-3afgpunj	97	14	A71	A71	NNP
cord-306921-3afgpunj	97	15	infection	infection	NN
cord-306921-3afgpunj	97	16	of	of	IN
cord-306921-3afgpunj	97	17	the	the	DT
cord-306921-3afgpunj	97	18	DLD	DLD	NNP
cord-306921-3afgpunj	97	19	intestinal	intestinal	JJ
cord-306921-3afgpunj	97	20	cells	cell	NNS
cord-306921-3afgpunj	97	21	[	[	-LRB-
cord-306921-3afgpunj	97	22	56	56	CD
cord-306921-3afgpunj	97	23	]	]	-RRB-
cord-306921-3afgpunj	97	24	.	.	.
cord-306921-3afgpunj	98	1	Another	another	DT
cord-306921-3afgpunj	98	2	attachment	attachment	NN
cord-306921-3afgpunj	98	3	receptor	receptor	NN
cord-306921-3afgpunj	98	4	;	;	:
cord-306921-3afgpunj	98	5	heparan	heparan	NN
cord-306921-3afgpunj	98	6	sulfate	sulfate	NN
cord-306921-3afgpunj	98	7	glycosaminoglycan	glycosaminoglycan	NN
cord-306921-3afgpunj	98	8	was	be	VBD
cord-306921-3afgpunj	98	9	also	also	RB
cord-306921-3afgpunj	98	10	identified	identify	VBN
cord-306921-3afgpunj	98	11	by	by	IN
cord-306921-3afgpunj	98	12	Tan	Tan	NNP
cord-306921-3afgpunj	98	13	and	and	CC
cord-306921-3afgpunj	98	14	colleagues	colleague	NNS
cord-306921-3afgpunj	98	15	pointing	point	VBG
cord-306921-3afgpunj	98	16	to	to	IN
cord-306921-3afgpunj	98	17	the	the	DT
cord-306921-3afgpunj	98	18	number	number	NN
cord-306921-3afgpunj	98	19	of	of	IN
cord-306921-3afgpunj	98	20	binding	bind	VBG
cord-306921-3afgpunj	98	21	options	option	NNS
cord-306921-3afgpunj	98	22	available	available	JJ
cord-306921-3afgpunj	98	23	for	for	IN
cord-306921-3afgpunj	98	24	EV	EV	NNP
cord-306921-3afgpunj	98	25	-	-	HYPH
cord-306921-3afgpunj	98	26	A71	A71	NNP
cord-306921-3afgpunj	98	27	virus	virus	NN
cord-306921-3afgpunj	98	28	[	[	-LRB-
cord-306921-3afgpunj	98	29	57	57	CD
cord-306921-3afgpunj	98	30	]	]	-RRB-
cord-306921-3afgpunj	98	31	.	.	.
cord-306921-3afgpunj	99	1	A	a	DT
cord-306921-3afgpunj	99	2	recent	recent	JJ
cord-306921-3afgpunj	99	3	study	study	NN
cord-306921-3afgpunj	99	4	by	by	IN
cord-306921-3afgpunj	99	5	Tseligka	Tseligka	NNP
cord-306921-3afgpunj	99	6	and	and	CC
cord-306921-3afgpunj	99	7	coworkers	coworker	NNS
cord-306921-3afgpunj	99	8	confirmed	confirm	VBD
cord-306921-3afgpunj	99	9	the	the	DT
cord-306921-3afgpunj	99	10	importance	importance	NN
cord-306921-3afgpunj	99	11	of	of	IN
cord-306921-3afgpunj	99	12	heparan	heparan	NN
cord-306921-3afgpunj	99	13	sulfate	sulfate	NN
cord-306921-3afgpunj	99	14	during	during	IN
cord-306921-3afgpunj	99	15	EV	EV	NNP
cord-306921-3afgpunj	99	16	-	-	HYPH
cord-306921-3afgpunj	99	17	A71	A71	NNP
cord-306921-3afgpunj	99	18	infection	infection	NN
cord-306921-3afgpunj	99	19	[	[	-LRB-
cord-306921-3afgpunj	99	20	58	58	CD
cord-306921-3afgpunj	99	21	]	]	-RRB-
cord-306921-3afgpunj	99	22	.	.	.
cord-306921-3afgpunj	100	1	This	this	DT
cord-306921-3afgpunj	100	2	explains	explain	VBZ
cord-306921-3afgpunj	100	3	the	the	DT
cord-306921-3afgpunj	100	4	wide	wide	JJ
cord-306921-3afgpunj	100	5	range	range	NN
cord-306921-3afgpunj	100	6	of	of	IN
cord-306921-3afgpunj	100	7	symptoms	symptom	NNS
cord-306921-3afgpunj	100	8	associated	associate	VBN
cord-306921-3afgpunj	100	9	with	with	IN
cord-306921-3afgpunj	100	10	EV	EV	NNP
cord-306921-3afgpunj	100	11	-	-	HYPH
cord-306921-3afgpunj	100	12	A71	A71	NNP
cord-306921-3afgpunj	100	13	infections	infection	NNS
cord-306921-3afgpunj	100	14	from	from	IN
cord-306921-3afgpunj	100	15	mild	mild	JJ
cord-306921-3afgpunj	100	16	infections	infection	NNS
cord-306921-3afgpunj	100	17	to	to	IN
cord-306921-3afgpunj	100	18	neurological	neurological	JJ
cord-306921-3afgpunj	100	19	complications	complication	NNS
cord-306921-3afgpunj	100	20	in	in	IN
cord-306921-3afgpunj	100	21	some	some	DT
cord-306921-3afgpunj	100	22	cases	case	NNS
cord-306921-3afgpunj	100	23	.	.	.
cord-306921-3afgpunj	101	1	Yang	Yang	NNP
cord-306921-3afgpunj	101	2	and	and	CC
cord-306921-3afgpunj	101	3	colleagues	colleague	NNS
cord-306921-3afgpunj	101	4	identified	identify	VBD
cord-306921-3afgpunj	101	5	the	the	DT
cord-306921-3afgpunj	101	6	interaction	interaction	NN
cord-306921-3afgpunj	101	7	between	between	IN
cord-306921-3afgpunj	101	8	EV	EV	NNP
cord-306921-3afgpunj	101	9	-	-	HYPH
cord-306921-3afgpunj	101	10	A71	A71	NNP
cord-306921-3afgpunj	101	11	viral	viral	JJ
cord-306921-3afgpunj	101	12	protein	protein	NN
cord-306921-3afgpunj	101	13	1	1	CD
cord-306921-3afgpunj	101	14	(	(	-LRB-
cord-306921-3afgpunj	101	15	VP1	VP1	NNP
cord-306921-3afgpunj	101	16	)	)	-RRB-
cord-306921-3afgpunj	101	17	and	and	CC
cord-306921-3afgpunj	101	18	human	human	JJ
cord-306921-3afgpunj	101	19	annexin	annexin	JJ
cord-306921-3afgpunj	101	20	2	2	CD
cord-306921-3afgpunj	101	21	protein	protein	NN
cord-306921-3afgpunj	101	22	thereby	thereby	RB
cord-306921-3afgpunj	101	23	enhancing	enhance	VBG
cord-306921-3afgpunj	101	24	EV	EV	NNP
cord-306921-3afgpunj	101	25	-	-	HYPH
cord-306921-3afgpunj	101	26	A71	A71	NNP
cord-306921-3afgpunj	101	27	infection	infection	NN
cord-306921-3afgpunj	101	28	[	[	-LRB-
cord-306921-3afgpunj	101	29	59	59	CD
cord-306921-3afgpunj	101	30	]	]	-RRB-
cord-306921-3afgpunj	101	31	.	.	.
cord-306921-3afgpunj	102	1	Cell	cell	NN
cord-306921-3afgpunj	102	2	surface	surface	NN
cord-306921-3afgpunj	102	3	vimentin	vimentin	NN
cord-306921-3afgpunj	102	4	has	have	VBZ
cord-306921-3afgpunj	102	5	also	also	RB
cord-306921-3afgpunj	102	6	been	be	VBN
cord-306921-3afgpunj	102	7	described	describe	VBN
cord-306921-3afgpunj	102	8	as	as	IN
cord-306921-3afgpunj	102	9	attachment	attachment	NN
cord-306921-3afgpunj	102	10	receptor	receptor	NN
cord-306921-3afgpunj	102	11	for	for	IN
cord-306921-3afgpunj	102	12	EV	EV	NNP
cord-306921-3afgpunj	102	13	-	-	HYPH
cord-306921-3afgpunj	102	14	A71	A71	NNP
cord-306921-3afgpunj	102	15	pointing	point	VBG
cord-306921-3afgpunj	102	16	to	to	IN
cord-306921-3afgpunj	102	17	the	the	DT
cord-306921-3afgpunj	102	18	presence	presence	NN
cord-306921-3afgpunj	102	19	of	of	IN
cord-306921-3afgpunj	102	20	array	array	NN
cord-306921-3afgpunj	102	21	of	of	IN
cord-306921-3afgpunj	102	22	receptors	receptor	NNS
cord-306921-3afgpunj	102	23	responsible	responsible	JJ
cord-306921-3afgpunj	102	24	for	for	IN
cord-306921-3afgpunj	102	25	the	the	DT
cord-306921-3afgpunj	102	26	viral	viral	JJ
cord-306921-3afgpunj	102	27	entry	entry	NN
cord-306921-3afgpunj	102	28	into	into	IN
cord-306921-3afgpunj	102	29	the	the	DT
cord-306921-3afgpunj	102	30	cells	cell	NNS
cord-306921-3afgpunj	102	31	[	[	-LRB-
cord-306921-3afgpunj	102	32	60	60	CD
cord-306921-3afgpunj	102	33	]	]	-RRB-
cord-306921-3afgpunj	102	34	.	.	.
cord-306921-3afgpunj	103	1	Using	use	VBG
cord-306921-3afgpunj	103	2	glycoproteomic	glycoproteomic	NNP
cord-306921-3afgpunj	103	3	approach	approach	NN
cord-306921-3afgpunj	103	4	,	,	,
cord-306921-3afgpunj	103	5	Su	Su	NNP
cord-306921-3afgpunj	103	6	and	and	CC
cord-306921-3afgpunj	103	7	colleagues	colleague	NNS
cord-306921-3afgpunj	103	8	identified	identify	VBD
cord-306921-3afgpunj	103	9	cell	cell	NN
cord-306921-3afgpunj	103	10	surface	surface	NN
cord-306921-3afgpunj	103	11	nucleolin	nucleolin	NN
cord-306921-3afgpunj	103	12	to	to	TO
cord-306921-3afgpunj	103	13	be	be	VB
cord-306921-3afgpunj	103	14	aiding	aid	VBG
cord-306921-3afgpunj	103	15	in	in	IN
cord-306921-3afgpunj	103	16	EV	EV	NNP
cord-306921-3afgpunj	103	17	-	-	HYPH
cord-306921-3afgpunj	103	18	A71	A71	NNP
cord-306921-3afgpunj	103	19	attachment	attachment	NN
cord-306921-3afgpunj	103	20	and	and	CC
cord-306921-3afgpunj	103	21	entry	entry	NN
cord-306921-3afgpunj	103	22	by	by	IN
cord-306921-3afgpunj	103	23	interacting	interact	VBG
cord-306921-3afgpunj	103	24	with	with	IN
cord-306921-3afgpunj	103	25	viral	viral	JJ
cord-306921-3afgpunj	103	26	protein	protein	NN
cord-306921-3afgpunj	103	27	1	1	CD
cord-306921-3afgpunj	103	28	[	[	-LRB-
cord-306921-3afgpunj	103	29	61	61	CD
cord-306921-3afgpunj	103	30	]	]	-RRB-
cord-306921-3afgpunj	103	31	.	.	.
cord-306921-3afgpunj	104	1	Cell	cell	NN
cord-306921-3afgpunj	104	2	surface	surface	NN
cord-306921-3afgpunj	104	3	prohibitin	prohibitin	NNP
cord-306921-3afgpunj	104	4	was	be	VBD
cord-306921-3afgpunj	104	5	recently	recently	RB
cord-306921-3afgpunj	104	6	identified	identify	VBN
cord-306921-3afgpunj	104	7	as	as	IN
cord-306921-3afgpunj	104	8	the	the	DT
cord-306921-3afgpunj	104	9	first	first	JJ
cord-306921-3afgpunj	104	10	possible	possible	JJ
cord-306921-3afgpunj	104	11	host	host	NN
cord-306921-3afgpunj	104	12	factor	factor	NN
cord-306921-3afgpunj	104	13	that	that	WDT
cord-306921-3afgpunj	104	14	interacts	interact	VBZ
cord-306921-3afgpunj	104	15	with	with	IN
cord-306921-3afgpunj	104	16	EV	EV	NNP
cord-306921-3afgpunj	104	17	-	-	HYPH
cord-306921-3afgpunj	104	18	A71	A71	NNP
cord-306921-3afgpunj	104	19	during	during	IN
cord-306921-3afgpunj	104	20	viral	viral	JJ
cord-306921-3afgpunj	104	21	entry	entry	NN
cord-306921-3afgpunj	104	22	into	into	IN
cord-306921-3afgpunj	104	23	neuronal	neuronal	JJ
cord-306921-3afgpunj	104	24	cells	cell	NNS
cord-306921-3afgpunj	104	25	thereby	thereby	RB
cord-306921-3afgpunj	104	26	aiding	aid	VBG
cord-306921-3afgpunj	104	27	in	in	IN
cord-306921-3afgpunj	104	28	the	the	DT
cord-306921-3afgpunj	104	29	neuropathies	neuropathy	NNS
cord-306921-3afgpunj	104	30	associated	associate	VBN
cord-306921-3afgpunj	104	31	with	with	IN
cord-306921-3afgpunj	104	32	EV	EV	NNP
cord-306921-3afgpunj	104	33	-	-	HYPH
cord-306921-3afgpunj	104	34	A71	A71	NNP
cord-306921-3afgpunj	104	35	infections	infection	NNS
cord-306921-3afgpunj	104	36	[	[	-LRB-
cord-306921-3afgpunj	104	37	62	62	CD
cord-306921-3afgpunj	104	38	]	]	-RRB-
cord-306921-3afgpunj	104	39	.	.	.
cord-306921-3afgpunj	105	1	Fibronectin	Fibronectin	NNP
cord-306921-3afgpunj	105	2	;	;	:
cord-306921-3afgpunj	105	3	a	a	DT
cord-306921-3afgpunj	105	4	high	high	JJ
cord-306921-3afgpunj	105	5	molecular	molecular	JJ
cord-306921-3afgpunj	105	6	weight	weight	NN
cord-306921-3afgpunj	105	7	glycoprotein	glycoprotein	NN
cord-306921-3afgpunj	105	8	joins	join	VBZ
cord-306921-3afgpunj	105	9	the	the	DT
cord-306921-3afgpunj	105	10	list	list	NN
cord-306921-3afgpunj	105	11	of	of	IN
cord-306921-3afgpunj	105	12	the	the	DT
cord-306921-3afgpunj	105	13	wide	wide	JJ
cord-306921-3afgpunj	105	14	array	array	NN
cord-306921-3afgpunj	105	15	of	of	IN
cord-306921-3afgpunj	105	16	EV	EV	NNP
cord-306921-3afgpunj	105	17	-	-	HYPH
cord-306921-3afgpunj	105	18	A71	A71	NNP
cord-306921-3afgpunj	105	19	receptors	receptor	NNS
cord-306921-3afgpunj	105	20	to	to	TO
cord-306921-3afgpunj	105	21	be	be	VB
cord-306921-3afgpunj	105	22	discovered	discover	VBN
cord-306921-3afgpunj	105	23	recently	recently	RB
cord-306921-3afgpunj	105	24	by	by	IN
cord-306921-3afgpunj	105	25	Qiao	Qiao	NNP
cord-306921-3afgpunj	105	26	and	and	CC
cord-306921-3afgpunj	105	27	colleagues	colleague	NNS
cord-306921-3afgpunj	105	28	[	[	-LRB-
cord-306921-3afgpunj	105	29	63	63	CD
cord-306921-3afgpunj	105	30	]	]	-RRB-
cord-306921-3afgpunj	105	31	.	.	.
cord-306921-3afgpunj	106	1	This	this	DT
cord-306921-3afgpunj	106	2	study	study	NN
cord-306921-3afgpunj	106	3	postulates	postulate	VBZ
cord-306921-3afgpunj	106	4	that	that	IN
cord-306921-3afgpunj	106	5	EV	EV	NNP
cord-306921-3afgpunj	106	6	-	-	HYPH
cord-306921-3afgpunj	106	7	A71	A71	NNP
cord-306921-3afgpunj	106	8	may	may	MD
cord-306921-3afgpunj	106	9	be	be	VB
cord-306921-3afgpunj	106	10	binding	bind	VBG
cord-306921-3afgpunj	106	11	to	to	IN
cord-306921-3afgpunj	106	12	the	the	DT
cord-306921-3afgpunj	106	13	fibronectin	fibronectin	NN
cord-306921-3afgpunj	106	14	protein	protein	NN
cord-306921-3afgpunj	106	15	through	through	IN
cord-306921-3afgpunj	106	16	its	-PRON-	PRP$
cord-306921-3afgpunj	106	17	VP1	vp1	NN
cord-306921-3afgpunj	106	18	structural	structural	JJ
cord-306921-3afgpunj	106	19	protein	protein	NN
cord-306921-3afgpunj	106	20	.	.	.
cord-306921-3afgpunj	107	1	A	a	DT
cord-306921-3afgpunj	107	2	recent	recent	JJ
cord-306921-3afgpunj	107	3	genome	genome	NN
cord-306921-3afgpunj	107	4	-	-	HYPH
cord-306921-3afgpunj	107	5	wide	wide	JJ
cord-306921-3afgpunj	107	6	RNAi	RNAi	NNS
cord-306921-3afgpunj	107	7	screening	screening	NN
cord-306921-3afgpunj	107	8	by	by	IN
cord-306921-3afgpunj	107	9	Yueng	Yueng	NNP
cord-306921-3afgpunj	107	10	and	and	CC
cord-306921-3afgpunj	107	11	colleagues	colleague	NNS
cord-306921-3afgpunj	107	12	identified	identify	VBD
cord-306921-3afgpunj	107	13	human	human	JJ
cord-306921-3afgpunj	107	14	tryptophanyl	tryptophanyl	NNP
cord-306921-3afgpunj	107	15	-	-	HYPH
cord-306921-3afgpunj	107	16	tRNA	tRNA	NNP
cord-306921-3afgpunj	107	17	sythetase	sythetase	NNP
cord-306921-3afgpunj	107	18	(	(	-LRB-
cord-306921-3afgpunj	107	19	hWARS	hWARS	NNP
cord-306921-3afgpunj	107	20	)	)	-RRB-
cord-306921-3afgpunj	107	21	as	as	IN
cord-306921-3afgpunj	107	22	an	an	DT
cord-306921-3afgpunj	107	23	entry	entry	NN
cord-306921-3afgpunj	107	24	factor	factor	NN
cord-306921-3afgpunj	107	25	for	for	IN
cord-306921-3afgpunj	107	26	EV	EV	NNP
cord-306921-3afgpunj	107	27	-	-	HYPH
cord-306921-3afgpunj	107	28	A71	A71	NNP
cord-306921-3afgpunj	107	29	as	as	RB
cord-306921-3afgpunj	107	30	well	well	RB
cord-306921-3afgpunj	107	31	as	as	IN
cord-306921-3afgpunj	107	32	CV	cv	NN
cord-306921-3afgpunj	107	33	-	-	HYPH
cord-306921-3afgpunj	107	34	A16	A16	NNP
cord-306921-3afgpunj	107	35	and	and	CC
cord-306921-3afgpunj	107	36	EV	EV	NNP
cord-306921-3afgpunj	107	37	-	-	HYPH
cord-306921-3afgpunj	107	38	D68	D68	NNP
cord-306921-3afgpunj	107	39	[	[	-LRB-
cord-306921-3afgpunj	107	40	64	64	CD
cord-306921-3afgpunj	107	41	]	]	-RRB-
cord-306921-3afgpunj	107	42	.	.	.
cord-306921-3afgpunj	108	1	The	the	DT
cord-306921-3afgpunj	108	2	results	result	NNS
cord-306921-3afgpunj	108	3	from	from	IN
cord-306921-3afgpunj	108	4	this	this	DT
cord-306921-3afgpunj	108	5	study	study	NN
cord-306921-3afgpunj	108	6	proposed	propose	VBD
cord-306921-3afgpunj	108	7	an	an	DT
cord-306921-3afgpunj	108	8	interesting	interesting	JJ
cord-306921-3afgpunj	108	9	view	view	NN
cord-306921-3afgpunj	108	10	as	as	IN
cord-306921-3afgpunj	108	11	the	the	DT
cord-306921-3afgpunj	108	12	hWARS	hwar	NNS
cord-306921-3afgpunj	108	13	are	be	VBP
cord-306921-3afgpunj	108	14	not	not	RB
cord-306921-3afgpunj	108	15	anchored	anchor	VBN
cord-306921-3afgpunj	108	16	on	on	IN
cord-306921-3afgpunj	108	17	the	the	DT
cord-306921-3afgpunj	108	18	membrane	membrane	NN
cord-306921-3afgpunj	108	19	surface	surface	NN
cord-306921-3afgpunj	108	20	where	where	WRB
cord-306921-3afgpunj	108	21	it	-PRON-	PRP
cord-306921-3afgpunj	108	22	may	may	MD
cord-306921-3afgpunj	108	23	be	be	VB
cord-306921-3afgpunj	108	24	acting	act	VBG
cord-306921-3afgpunj	108	25	as	as	IN
cord-306921-3afgpunj	108	26	a	a	DT
cord-306921-3afgpunj	108	27	receptor	receptor	NN
cord-306921-3afgpunj	108	28	;	;	:
cord-306921-3afgpunj	108	29	thus	thus	RB
cord-306921-3afgpunj	108	30	,	,	,
cord-306921-3afgpunj	108	31	there	there	EX
cord-306921-3afgpunj	108	32	is	be	VBZ
cord-306921-3afgpunj	108	33	need	need	NN
cord-306921-3afgpunj	108	34	for	for	IN
cord-306921-3afgpunj	108	35	further	further	JJ
cord-306921-3afgpunj	108	36	studies	study	NNS
cord-306921-3afgpunj	108	37	to	to	TO
cord-306921-3afgpunj	108	38	unravel	unravel	VB
cord-306921-3afgpunj	108	39	the	the	DT
cord-306921-3afgpunj	108	40	exact	exact	JJ
cord-306921-3afgpunj	108	41	mechanism	mechanism	NN
cord-306921-3afgpunj	108	42	of	of	IN
cord-306921-3afgpunj	108	43	action	action	NN
cord-306921-3afgpunj	108	44	of	of	IN
cord-306921-3afgpunj	108	45	these	these	DT
cord-306921-3afgpunj	108	46	proteins	protein	NNS
cord-306921-3afgpunj	108	47	.	.	.
cord-306921-3afgpunj	109	1	As	as	IN
cord-306921-3afgpunj	109	2	suggested	suggest	VBN
cord-306921-3afgpunj	109	3	by	by	IN
cord-306921-3afgpunj	109	4	Perlman	Perlman	NNP
cord-306921-3afgpunj	109	5	and	and	CC
cord-306921-3afgpunj	109	6	Gallagher	Gallagher	NNP
cord-306921-3afgpunj	109	7	[	[	-LRB-
cord-306921-3afgpunj	109	8	65	65	CD
cord-306921-3afgpunj	109	9	]	]	-RRB-
cord-306921-3afgpunj	110	1	in	in	IN
cord-306921-3afgpunj	110	2	their	-PRON-	PRP$
cord-306921-3afgpunj	110	3	commentary	commentary	NN
cord-306921-3afgpunj	110	4	review	review	NN
cord-306921-3afgpunj	110	5	on	on	IN
cord-306921-3afgpunj	110	6	the	the	DT
cord-306921-3afgpunj	110	7	findings	finding	NNS
cord-306921-3afgpunj	110	8	from	from	IN
cord-306921-3afgpunj	110	9	Yueng	Yueng	NNP
cord-306921-3afgpunj	110	10	's	's	POS
cord-306921-3afgpunj	110	11	group	group	NN
cord-306921-3afgpunj	110	12	,	,	,
cord-306921-3afgpunj	110	13	we	-PRON-	PRP
cord-306921-3afgpunj	110	14	support	support	VBP
cord-306921-3afgpunj	110	15	the	the	DT
cord-306921-3afgpunj	110	16	need	need	NN
cord-306921-3afgpunj	110	17	to	to	TO
cord-306921-3afgpunj	110	18	further	further	RB
cord-306921-3afgpunj	110	19	evaluate	evaluate	VB
cord-306921-3afgpunj	110	20	mechanisms	mechanism	NNS
cord-306921-3afgpunj	110	21	of	of	IN
cord-306921-3afgpunj	110	22	the	the	DT
cord-306921-3afgpunj	110	23	three	three	CD
cord-306921-3afgpunj	110	24	known	know	VBN
cord-306921-3afgpunj	110	25	EV	EV	NNP
cord-306921-3afgpunj	110	26	-	-	HYPH
cord-306921-3afgpunj	110	27	A71	A71	NNP
cord-306921-3afgpunj	110	28	entry	entry	NN
cord-306921-3afgpunj	110	29	receptors	receptor	NNS
cord-306921-3afgpunj	110	30	to	to	TO
cord-306921-3afgpunj	110	31	find	find	VB
cord-306921-3afgpunj	110	32	out	out	RP
cord-306921-3afgpunj	110	33	if	if	IN
cord-306921-3afgpunj	110	34	there	there	EX
cord-306921-3afgpunj	110	35	is	be	VBZ
cord-306921-3afgpunj	110	36	any	any	DT
cord-306921-3afgpunj	110	37	interactions	interaction	NNS
cord-306921-3afgpunj	110	38	or	or	CC
cord-306921-3afgpunj	110	39	if	if	IN
cord-306921-3afgpunj	110	40	they	-PRON-	PRP
cord-306921-3afgpunj	110	41	are	be	VBP
cord-306921-3afgpunj	110	42	all	all	DT
cord-306921-3afgpunj	110	43	needed	need	VBN
cord-306921-3afgpunj	110	44	for	for	IN
cord-306921-3afgpunj	110	45	effective	effective	JJ
cord-306921-3afgpunj	110	46	entry	entry	NN
cord-306921-3afgpunj	110	47	of	of	IN
cord-306921-3afgpunj	110	48	the	the	DT
cord-306921-3afgpunj	110	49	virus	virus	NN
cord-306921-3afgpunj	110	50	into	into	IN
cord-306921-3afgpunj	110	51	susceptible	susceptible	JJ
cord-306921-3afgpunj	110	52	cells	cell	NNS
cord-306921-3afgpunj	110	53	.	.	.
cord-306921-3afgpunj	111	1	Possible	possible	JJ
cord-306921-3afgpunj	111	2	mode	mode	NN
cord-306921-3afgpunj	111	3	of	of	IN
cord-306921-3afgpunj	111	4	action	action	NN
cord-306921-3afgpunj	111	5	for	for	IN
cord-306921-3afgpunj	111	6	this	this	DT
cord-306921-3afgpunj	111	7	new	new	JJ
cord-306921-3afgpunj	111	8	perspective	perspective	NN
cord-306921-3afgpunj	111	9	in	in	IN
cord-306921-3afgpunj	111	10	EV	EV	NNP
cord-306921-3afgpunj	111	11	-	-	HYPH
cord-306921-3afgpunj	111	12	A71	A71	NNP
cord-306921-3afgpunj	111	13	infection	infection	NN
cord-306921-3afgpunj	111	14	has	have	VBZ
cord-306921-3afgpunj	111	15	been	be	VBN
cord-306921-3afgpunj	111	16	extensively	extensively	RB
cord-306921-3afgpunj	111	17	reviewed	review	VBN
cord-306921-3afgpunj	111	18	in	in	IN
cord-306921-3afgpunj	111	19	the	the	DT
cord-306921-3afgpunj	111	20	commentary	commentary	NN
cord-306921-3afgpunj	111	21	issue	issue	NN
cord-306921-3afgpunj	111	22	by	by	IN
cord-306921-3afgpunj	111	23	Perlman	Perlman	NNP
cord-306921-3afgpunj	111	24	and	and	CC
cord-306921-3afgpunj	111	25	Gallagher	Gallagher	NNP
cord-306921-3afgpunj	111	26	[	[	-LRB-
cord-306921-3afgpunj	111	27	65	65	CD
cord-306921-3afgpunj	111	28	]	]	-RRB-
cord-306921-3afgpunj	111	29	.	.	.
cord-306921-3afgpunj	112	1	Given	give	VBN
cord-306921-3afgpunj	112	2	that	that	DT
cord-306921-3afgpunj	112	3	EV	EV	NNP
cord-306921-3afgpunj	112	4	-	-	HYPH
cord-306921-3afgpunj	112	5	D68	D68	NNP
cord-306921-3afgpunj	112	6	and	and	CC
cord-306921-3afgpunj	112	7	CV	CV	NNP
cord-306921-3afgpunj	112	8	-	-	HYPH
cord-306921-3afgpunj	112	9	A16	a16	NN
cord-306921-3afgpunj	112	10	viruses	virus	NNS
cord-306921-3afgpunj	112	11	do	do	VBP
cord-306921-3afgpunj	112	12	not	not	RB
cord-306921-3afgpunj	112	13	depend	depend	VB
cord-306921-3afgpunj	112	14	on	on	IN
cord-306921-3afgpunj	112	15	PSGL1	PSGL1	NNP
cord-306921-3afgpunj	112	16	and	and	CC
cord-306921-3afgpunj	112	17	SCARB2	SCARB2	NNS
cord-306921-3afgpunj	112	18	receptors	receptor	NNS
cord-306921-3afgpunj	112	19	for	for	IN
cord-306921-3afgpunj	112	20	entry	entry	NN
cord-306921-3afgpunj	112	21	into	into	IN
cord-306921-3afgpunj	112	22	cells	cell	NNS
cord-306921-3afgpunj	112	23	,	,	,
cord-306921-3afgpunj	112	24	the	the	DT
cord-306921-3afgpunj	112	25	findings	finding	NNS
cord-306921-3afgpunj	112	26	of	of	IN
cord-306921-3afgpunj	112	27	this	this	DT
cord-306921-3afgpunj	112	28	study	study	NN
cord-306921-3afgpunj	112	29	will	will	MD
cord-306921-3afgpunj	112	30	be	be	VB
cord-306921-3afgpunj	112	31	key	key	JJ
cord-306921-3afgpunj	112	32	in	in	IN
cord-306921-3afgpunj	112	33	understanding	understand	VBG
cord-306921-3afgpunj	112	34	the	the	DT
cord-306921-3afgpunj	112	35	pathogenesis	pathogenesis	NN
cord-306921-3afgpunj	112	36	of	of	IN
cord-306921-3afgpunj	112	37	these	these	DT
cord-306921-3afgpunj	112	38	viruses	virus	NNS
cord-306921-3afgpunj	112	39	upon	upon	IN
cord-306921-3afgpunj	112	40	validation	validation	NN
cord-306921-3afgpunj	112	41	of	of	IN
cord-306921-3afgpunj	112	42	the	the	DT
cord-306921-3afgpunj	112	43	exact	exact	JJ
cord-306921-3afgpunj	112	44	mechanism	mechanism	NN
cord-306921-3afgpunj	112	45	of	of	IN
cord-306921-3afgpunj	112	46	action	action	NN
cord-306921-3afgpunj	112	47	.	.	.
cord-306921-3afgpunj	113	1	This	this	DT
cord-306921-3afgpunj	113	2	was	be	VBD
cord-306921-3afgpunj	113	3	the	the	DT
cord-306921-3afgpunj	113	4	first	first	JJ
cord-306921-3afgpunj	113	5	report	report	NN
cord-306921-3afgpunj	113	6	linking	link	VBG
cord-306921-3afgpunj	113	7	interferon	interferon	NN
cord-306921-3afgpunj	113	8	gamma	gamma	NN
cord-306921-3afgpunj	113	9	to	to	IN
cord-306921-3afgpunj	113	10	inducing	induce	VBG
cord-306921-3afgpunj	113	11	viral	viral	JJ
cord-306921-3afgpunj	113	12	entry	entry	NN
cord-306921-3afgpunj	113	13	into	into	IN
cord-306921-3afgpunj	113	14	the	the	DT
cord-306921-3afgpunj	113	15	cells	cell	NNS
cord-306921-3afgpunj	113	16	.	.	.
cord-306921-3afgpunj	114	1	The	the	DT
cord-306921-3afgpunj	114	2	continued	continued	JJ
cord-306921-3afgpunj	114	3	research	research	NN
cord-306921-3afgpunj	114	4	aiming	aim	VBG
cord-306921-3afgpunj	114	5	at	at	IN
cord-306921-3afgpunj	114	6	documenting	document	VBG
cord-306921-3afgpunj	114	7	the	the	DT
cord-306921-3afgpunj	114	8	array	array	NN
cord-306921-3afgpunj	114	9	of	of	IN
cord-306921-3afgpunj	114	10	receptors	receptor	NNS
cord-306921-3afgpunj	114	11	for	for	IN
cord-306921-3afgpunj	114	12	EV	EV	NNP
cord-306921-3afgpunj	114	13	-	-	HYPH
cord-306921-3afgpunj	114	14	A71	A71	NNP
cord-306921-3afgpunj	114	15	and	and	CC
cord-306921-3afgpunj	114	16	other	other	JJ
cord-306921-3afgpunj	114	17	picornaviruses	picornavirus	NNS
cord-306921-3afgpunj	114	18	will	will	MD
cord-306921-3afgpunj	114	19	provide	provide	VB
cord-306921-3afgpunj	114	20	vital	vital	JJ
cord-306921-3afgpunj	114	21	information	information	NN
cord-306921-3afgpunj	114	22	in	in	IN
cord-306921-3afgpunj	114	23	design	design	NN
cord-306921-3afgpunj	114	24	of	of	IN
cord-306921-3afgpunj	114	25	antiviral	antiviral	JJ
cord-306921-3afgpunj	114	26	therapies	therapy	NNS
cord-306921-3afgpunj	114	27	and	and	CC
cord-306921-3afgpunj	114	28	vaccines	vaccine	NNS
cord-306921-3afgpunj	114	29	.	.	.
cord-306921-3afgpunj	115	1	Completely	completely	RB
cord-306921-3afgpunj	115	2	mapping	map	VBG
cord-306921-3afgpunj	115	3	out	out	RP
cord-306921-3afgpunj	115	4	all	all	PDT
cord-306921-3afgpunj	115	5	the	the	DT
cord-306921-3afgpunj	115	6	essential	essential	JJ
cord-306921-3afgpunj	115	7	host	host	NN
cord-306921-3afgpunj	115	8	proteins	protein	NNS
cord-306921-3afgpunj	115	9	acting	act	VBG
cord-306921-3afgpunj	115	10	as	as	IN
cord-306921-3afgpunj	115	11	functional	functional	JJ
cord-306921-3afgpunj	115	12	receptors	receptor	NNS
cord-306921-3afgpunj	115	13	for	for	IN
cord-306921-3afgpunj	115	14	EV	EV	NNP
cord-306921-3afgpunj	115	15	-	-	HYPH
cord-306921-3afgpunj	115	16	A71	A71	NNP
cord-306921-3afgpunj	115	17	will	will	MD
cord-306921-3afgpunj	115	18	provide	provide	VB
cord-306921-3afgpunj	115	19	a	a	DT
cord-306921-3afgpunj	115	20	rich	rich	JJ
cord-306921-3afgpunj	115	21	niche	niche	NN
cord-306921-3afgpunj	115	22	for	for	IN
cord-306921-3afgpunj	115	23	design	design	NN
cord-306921-3afgpunj	115	24	and	and	CC
cord-306921-3afgpunj	115	25	development	development	NN
cord-306921-3afgpunj	115	26	of	of	IN
cord-306921-3afgpunj	115	27	vaccines	vaccine	NNS
cord-306921-3afgpunj	115	28	and	and	CC
cord-306921-3afgpunj	115	29	therapy	therapy	NN
cord-306921-3afgpunj	115	30	against	against	IN
cord-306921-3afgpunj	115	31	infections	infection	NNS
cord-306921-3afgpunj	115	32	associated	associate	VBN
cord-306921-3afgpunj	115	33	with	with	IN
cord-306921-3afgpunj	115	34	it	-PRON-	PRP
cord-306921-3afgpunj	115	35	.	.	.
cord-306921-3afgpunj	116	1	The	the	DT
cord-306921-3afgpunj	116	2	existing	exist	VBG
cord-306921-3afgpunj	116	3	EV	EV	NNP
cord-306921-3afgpunj	116	4	-	-	HYPH
cord-306921-3afgpunj	116	5	A71	A71	NNP
cord-306921-3afgpunj	116	6	and	and	CC
cord-306921-3afgpunj	116	7	CV	CV	NNP
cord-306921-3afgpunj	116	8	-	-	HYPH
cord-306921-3afgpunj	116	9	A16	a16	NN
cord-306921-3afgpunj	116	10	receptors	receptor	NNS
cord-306921-3afgpunj	116	11	have	have	VBP
cord-306921-3afgpunj	116	12	not	not	RB
cord-306921-3afgpunj	116	13	been	be	VBN
cord-306921-3afgpunj	116	14	able	able	JJ
cord-306921-3afgpunj	116	15	to	to	TO
cord-306921-3afgpunj	116	16	completely	completely	RB
cord-306921-3afgpunj	116	17	explain	explain	VB
cord-306921-3afgpunj	116	18	the	the	DT
cord-306921-3afgpunj	116	19	pathogenesis	pathogenesis	NN
cord-306921-3afgpunj	116	20	of	of	IN
cord-306921-3afgpunj	116	21	hand	hand	NN
cord-306921-3afgpunj	116	22	,	,	,
cord-306921-3afgpunj	116	23	foot	foot	NN
cord-306921-3afgpunj	116	24	and	and	CC
cord-306921-3afgpunj	116	25	mouth	mouth	NN
cord-306921-3afgpunj	116	26	disease	disease	NN
cord-306921-3afgpunj	116	27	.	.	.
cord-306921-3afgpunj	117	1	Human	Human	NNP
cord-306921-3afgpunj	117	2	PSGL1	PSGL1	NNP
cord-306921-3afgpunj	117	3	for	for	IN
cord-306921-3afgpunj	117	4	example	example	NN
cord-306921-3afgpunj	117	5	seems	seem	VBZ
cord-306921-3afgpunj	117	6	to	to	TO
cord-306921-3afgpunj	117	7	only	only	RB
cord-306921-3afgpunj	117	8	facilitate	facilitate	VB
cord-306921-3afgpunj	117	9	a	a	DT
cord-306921-3afgpunj	117	10	small	small	JJ
cord-306921-3afgpunj	117	11	number	number	NN
cord-306921-3afgpunj	117	12	of	of	IN
cord-306921-3afgpunj	117	13	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	117	14	entry	entry	NN
cord-306921-3afgpunj	117	15	into	into	IN
cord-306921-3afgpunj	117	16	the	the	DT
cord-306921-3afgpunj	117	17	cells	cell	NNS
cord-306921-3afgpunj	117	18	,	,	,
cord-306921-3afgpunj	117	19	while	while	IN
cord-306921-3afgpunj	117	20	SCARB2	SCARB2	NNS
cord-306921-3afgpunj	117	21	has	have	VBZ
cord-306921-3afgpunj	117	22	been	be	VBN
cord-306921-3afgpunj	117	23	shown	show	VBN
cord-306921-3afgpunj	117	24	to	to	TO
cord-306921-3afgpunj	117	25	support	support	VB
cord-306921-3afgpunj	117	26	an	an	DT
cord-306921-3afgpunj	117	27	array	array	NN
cord-306921-3afgpunj	117	28	of	of	IN
cord-306921-3afgpunj	117	29	the	the	DT
cord-306921-3afgpunj	117	30	viruses	virus	NNS
cord-306921-3afgpunj	117	31	.	.	.
cord-306921-3afgpunj	118	1	This	this	DT
cord-306921-3afgpunj	118	2	points	point	VBZ
cord-306921-3afgpunj	118	3	out	out	RP
cord-306921-3afgpunj	118	4	to	to	IN
cord-306921-3afgpunj	118	5	the	the	DT
cord-306921-3afgpunj	118	6	need	need	NN
cord-306921-3afgpunj	118	7	of	of	IN
cord-306921-3afgpunj	118	8	a	a	DT
cord-306921-3afgpunj	118	9	more	more	RBR
cord-306921-3afgpunj	118	10	concerted	concerted	JJ
cord-306921-3afgpunj	118	11	efforts	effort	NNS
cord-306921-3afgpunj	118	12	to	to	TO
cord-306921-3afgpunj	118	13	identify	identify	VB
cord-306921-3afgpunj	118	14	and	and	CC
cord-306921-3afgpunj	118	15	establish	establish	VB
cord-306921-3afgpunj	118	16	all	all	PDT
cord-306921-3afgpunj	118	17	the	the	DT
cord-306921-3afgpunj	118	18	possible	possible	JJ
cord-306921-3afgpunj	118	19	functional	functional	JJ
cord-306921-3afgpunj	118	20	entry	entry	NN
cord-306921-3afgpunj	118	21	receptors	receptor	NNS
cord-306921-3afgpunj	118	22	for	for	IN
cord-306921-3afgpunj	118	23	EV	EV	NNP
cord-306921-3afgpunj	118	24	-	-	HYPH
cord-306921-3afgpunj	118	25	A71	A71	NNP
cord-306921-3afgpunj	118	26	.	.	.
cord-306921-3afgpunj	119	1	The	the	DT
cord-306921-3afgpunj	119	2	recently	recently	RB
cord-306921-3afgpunj	119	3	identified	identify	VBN
cord-306921-3afgpunj	119	4	hWARS	hWARS	NNP
cord-306921-3afgpunj	119	5	needs	need	VBZ
cord-306921-3afgpunj	119	6	to	to	TO
cord-306921-3afgpunj	119	7	be	be	VB
cord-306921-3afgpunj	119	8	further	further	RB
cord-306921-3afgpunj	119	9	be	be	VB
cord-306921-3afgpunj	119	10	validated	validate	VBN
cord-306921-3afgpunj	119	11	to	to	TO
cord-306921-3afgpunj	119	12	determine	determine	VB
cord-306921-3afgpunj	119	13	the	the	DT
cord-306921-3afgpunj	119	14	efficiency	efficiency	NN
cord-306921-3afgpunj	119	15	in	in	IN
cord-306921-3afgpunj	119	16	supporting	support	VBG
cord-306921-3afgpunj	119	17	entry	entry	NN
cord-306921-3afgpunj	119	18	of	of	IN
cord-306921-3afgpunj	119	19	the	the	DT
cord-306921-3afgpunj	119	20	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	119	21	reported	report	VBN
cord-306921-3afgpunj	119	22	from	from	IN
cord-306921-3afgpunj	119	23	this	this	DT
cord-306921-3afgpunj	119	24	study	study	NN
cord-306921-3afgpunj	119	25	.	.	.
cord-306921-3afgpunj	120	1	Much	much	JJ
cord-306921-3afgpunj	120	2	need	need	VBP
cord-306921-3afgpunj	120	3	to	to	TO
cord-306921-3afgpunj	120	4	be	be	VB
cord-306921-3afgpunj	120	5	done	do	VBN
cord-306921-3afgpunj	120	6	going	go	VBG
cord-306921-3afgpunj	120	7	forward	forward	RB
cord-306921-3afgpunj	120	8	to	to	TO
cord-306921-3afgpunj	120	9	fully	fully	RB
cord-306921-3afgpunj	120	10	understand	understand	VB
cord-306921-3afgpunj	120	11	the	the	DT
cord-306921-3afgpunj	120	12	pathogenesis	pathogenesis	NN
cord-306921-3afgpunj	120	13	of	of	IN
cord-306921-3afgpunj	120	14	the	the	DT
cord-306921-3afgpunj	120	15	hand	hand	NN
cord-306921-3afgpunj	120	16	,	,	,
cord-306921-3afgpunj	120	17	foot	foot	NN
cord-306921-3afgpunj	120	18	and	and	CC
cord-306921-3afgpunj	120	19	mouth	mouth	NN
cord-306921-3afgpunj	120	20	disease	disease	NN
cord-306921-3afgpunj	120	21	.	.	.
cord-306921-3afgpunj	121	1	With	with	IN
cord-306921-3afgpunj	121	2	a	a	DT
cord-306921-3afgpunj	121	3	full	full	JJ
cord-306921-3afgpunj	121	4	map	map	NN
cord-306921-3afgpunj	121	5	of	of	IN
cord-306921-3afgpunj	121	6	entry	entry	NN
cord-306921-3afgpunj	121	7	receptors	receptor	NNS
cord-306921-3afgpunj	121	8	or	or	CC
cord-306921-3afgpunj	121	9	factors	factor	NNS
cord-306921-3afgpunj	121	10	,	,	,
cord-306921-3afgpunj	121	11	we	-PRON-	PRP
cord-306921-3afgpunj	121	12	will	will	MD
cord-306921-3afgpunj	121	13	be	be	VB
cord-306921-3afgpunj	121	14	able	able	JJ
cord-306921-3afgpunj	121	15	to	to	TO
cord-306921-3afgpunj	121	16	design	design	VB
cord-306921-3afgpunj	121	17	antiviral	antiviral	JJ
cord-306921-3afgpunj	121	18	therapy	therapy	NN
cord-306921-3afgpunj	121	19	able	able	JJ
cord-306921-3afgpunj	121	20	to	to	TO
cord-306921-3afgpunj	121	21	block	block	VB
cord-306921-3afgpunj	121	22	the	the	DT
cord-306921-3afgpunj	121	23	entry	entry	NN
cord-306921-3afgpunj	121	24	pathway	pathway	NN
cord-306921-3afgpunj	121	25	of	of	IN
cord-306921-3afgpunj	121	26	the	the	DT
cord-306921-3afgpunj	121	27	viruses	virus	NNS
cord-306921-3afgpunj	121	28	thus	thus	RB
cord-306921-3afgpunj	121	29	limiting	limit	VBG
cord-306921-3afgpunj	121	30	viral	viral	JJ
cord-306921-3afgpunj	121	31	infections	infection	NNS
cord-306921-3afgpunj	121	32	.	.	.
cord-306921-3afgpunj	122	1	This	this	DT
cord-306921-3afgpunj	122	2	will	will	MD
cord-306921-3afgpunj	122	3	be	be	VB
cord-306921-3afgpunj	122	4	important	important	JJ
cord-306921-3afgpunj	122	5	in	in	IN
cord-306921-3afgpunj	122	6	the	the	DT
cord-306921-3afgpunj	122	7	design	design	NN
cord-306921-3afgpunj	122	8	of	of	IN
cord-306921-3afgpunj	122	9	antivirals	antiviral	NNS
cord-306921-3afgpunj	122	10	against	against	IN
cord-306921-3afgpunj	122	11	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	122	12	associated	associate	VBN
cord-306921-3afgpunj	122	13	with	with	IN
cord-306921-3afgpunj	122	14	the	the	DT
cord-306921-3afgpunj	122	15	hand	hand	NN
cord-306921-3afgpunj	122	16	,	,	,
cord-306921-3afgpunj	122	17	foot	foot	NN
cord-306921-3afgpunj	122	18	and	and	CC
cord-306921-3afgpunj	122	19	mouth	mouth	NN
cord-306921-3afgpunj	122	20	disease	disease	NN
cord-306921-3afgpunj	122	21	.	.	.
cord-306921-3afgpunj	123	1	Sialic	sialic	NN
cord-306921-3afgpunj	123	2	acid	acid	NN
cord-306921-3afgpunj	123	3	as	as	RB
cord-306921-3afgpunj	123	4	well	well	RB
cord-306921-3afgpunj	123	5	as	as	IN
cord-306921-3afgpunj	124	1	Intercellular	intercellular	JJ
cord-306921-3afgpunj	124	2	adhesion	adhesion	NN
cord-306921-3afgpunj	124	3	molecule-5	molecule-5	NN
cord-306921-3afgpunj	125	1	(	(	-LRB-
cord-306921-3afgpunj	125	2	ICAM	ICAM	NNP
cord-306921-3afgpunj	125	3	5	5	CD
cord-306921-3afgpunj	125	4	)	)	-RRB-
cord-306921-3afgpunj	125	5	have	have	VBP
cord-306921-3afgpunj	125	6	been	be	VBN
cord-306921-3afgpunj	125	7	identified	identify	VBN
cord-306921-3afgpunj	125	8	as	as	IN
cord-306921-3afgpunj	125	9	receptors	receptor	NNS
cord-306921-3afgpunj	125	10	for	for	IN
cord-306921-3afgpunj	125	11	enterovirus	enterovirus	NN
cord-306921-3afgpunj	125	12	D68	D68	NNP
cord-306921-3afgpunj	125	13	(	(	-LRB-
cord-306921-3afgpunj	125	14	EV	EV	NNP
cord-306921-3afgpunj	125	15	-	-	HYPH
cord-306921-3afgpunj	125	16	D68	D68	NNP
cord-306921-3afgpunj	125	17	)	)	-RRB-
cord-306921-3afgpunj	126	1	facilitating	facilitate	VBG
cord-306921-3afgpunj	126	2	entry	entry	NN
cord-306921-3afgpunj	126	3	into	into	IN
cord-306921-3afgpunj	126	4	susceptible	susceptible	JJ
cord-306921-3afgpunj	126	5	cells	cell	NNS
cord-306921-3afgpunj	126	6	[	[	-LRB-
cord-306921-3afgpunj	126	7	66	66	CD
cord-306921-3afgpunj	126	8	,	,	,
cord-306921-3afgpunj	126	9	67	67	CD
cord-306921-3afgpunj	126	10	]	]	-RRB-
cord-306921-3afgpunj	126	11	.	.	.
cord-306921-3afgpunj	127	1	The	the	DT
cord-306921-3afgpunj	127	2	coxsackievirus	coxsackievirus	NN
cord-306921-3afgpunj	127	3	-	-	HYPH
cord-306921-3afgpunj	127	4	adenovirus	adenovirus	NN
cord-306921-3afgpunj	127	5	receptor	receptor	NN
cord-306921-3afgpunj	127	6	(	(	-LRB-
cord-306921-3afgpunj	127	7	CAR	car	NN
cord-306921-3afgpunj	127	8	)	)	-RRB-
cord-306921-3afgpunj	127	9	protein	protein	NN
cord-306921-3afgpunj	127	10	was	be	VBD
cord-306921-3afgpunj	127	11	the	the	DT
cord-306921-3afgpunj	127	12	first	first	JJ
cord-306921-3afgpunj	127	13	receptor	receptor	NN
cord-306921-3afgpunj	127	14	to	to	TO
cord-306921-3afgpunj	127	15	be	be	VB
cord-306921-3afgpunj	127	16	identified	identify	VBN
cord-306921-3afgpunj	127	17	for	for	IN
cord-306921-3afgpunj	127	18	coxsackie	coxsackie	NNP
cord-306921-3afgpunj	127	19	B	B	NNP
cord-306921-3afgpunj	127	20	virus	virus	NN
cord-306921-3afgpunj	127	21	subgroups	subgroup	VBZ
cord-306921-3afgpunj	127	22	A	A	NNP
cord-306921-3afgpunj	127	23	,	,	,
cord-306921-3afgpunj	127	24	C	C	NNP
cord-306921-3afgpunj	127	25	,	,	,
cord-306921-3afgpunj	127	26	D	D	NNP
cord-306921-3afgpunj	127	27	E	e	NN
cord-306921-3afgpunj	127	28	and	and	CC
cord-306921-3afgpunj	127	29	F	F	NNP
cord-306921-3afgpunj	127	30	[	[	-LRB-
cord-306921-3afgpunj	127	31	68	68	CD
cord-306921-3afgpunj	127	32	,	,	,
cord-306921-3afgpunj	127	33	69	69	CD
cord-306921-3afgpunj	127	34	]	]	-RRB-
cord-306921-3afgpunj	127	35	.	.	.
cord-306921-3afgpunj	128	1	Thereafter	thereafter	RB
cord-306921-3afgpunj	128	2	,	,	,
cord-306921-3afgpunj	128	3	other	other	JJ
cord-306921-3afgpunj	128	4	receptors	receptor	NNS
cord-306921-3afgpunj	128	5	for	for	IN
cord-306921-3afgpunj	128	6	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	128	7	A	A	NNP
cord-306921-3afgpunj	128	8	24	24	CD
cord-306921-3afgpunj	128	9	and	and	CC
cord-306921-3afgpunj	128	10	coxsackievirus	coxsackievirus	JJ
cord-306921-3afgpunj	128	11	A24	A24	NNP
cord-306921-3afgpunj	128	12	variant	variant	NN
cord-306921-3afgpunj	128	13	(	(	-LRB-
cord-306921-3afgpunj	128	14	CV	cv	NN
cord-306921-3afgpunj	128	15	-	-	HYPH
cord-306921-3afgpunj	128	16	A24v	a24v	NN
cord-306921-3afgpunj	128	17	)	)	-RRB-
cord-306921-3afgpunj	128	18	responsible	responsible	JJ
cord-306921-3afgpunj	128	19	for	for	IN
cord-306921-3afgpunj	128	20	acute	acute	JJ
cord-306921-3afgpunj	128	21	hemorrhagic	hemorrhagic	JJ
cord-306921-3afgpunj	128	22	conjunctivitis	conjunctivitis	NN
cord-306921-3afgpunj	128	23	(	(	-LRB-
cord-306921-3afgpunj	128	24	AHC	AHC	NNP
cord-306921-3afgpunj	128	25	)	)	-RRB-
cord-306921-3afgpunj	128	26	have	have	VBP
cord-306921-3afgpunj	128	27	been	be	VBN
cord-306921-3afgpunj	128	28	described	describe	VBN
cord-306921-3afgpunj	128	29	.	.	.
cord-306921-3afgpunj	129	1	ICAM-1	ICAM-1	NNP
cord-306921-3afgpunj	129	2	was	be	VBD
cord-306921-3afgpunj	129	3	identified	identify	VBN
cord-306921-3afgpunj	129	4	as	as	IN
cord-306921-3afgpunj	129	5	an	an	DT
cord-306921-3afgpunj	129	6	uncoating	uncoate	VBG
cord-306921-3afgpunj	129	7	receptor	receptor	NN
cord-306921-3afgpunj	129	8	for	for	IN
cord-306921-3afgpunj	129	9	CV	CV	NNP
cord-306921-3afgpunj	129	10	-	-	HYPH
cord-306921-3afgpunj	129	11	A21	A21	NNP
cord-306921-3afgpunj	129	12	;	;	:
cord-306921-3afgpunj	129	13	sialic	sialic	JJ
cord-306921-3afgpunj	129	14	acid	acid	NN
cord-306921-3afgpunj	129	15	as	as	IN
cord-306921-3afgpunj	129	16	an	an	DT
cord-306921-3afgpunj	129	17	attachment	attachment	NN
cord-306921-3afgpunj	129	18	receptor	receptor	NN
cord-306921-3afgpunj	129	19	for	for	IN
cord-306921-3afgpunj	129	20	CV	cv	NN
cord-306921-3afgpunj	129	21	-	-	HYPH
cord-306921-3afgpunj	129	22	A24v	a24v	NN
cord-306921-3afgpunj	129	23	[	[	-LRB-
cord-306921-3afgpunj	129	24	70	70	CD
cord-306921-3afgpunj	129	25	]	]	-RRB-
cord-306921-3afgpunj	129	26	.	.	.
cord-306921-3afgpunj	130	1	Low	low	JJ
cord-306921-3afgpunj	130	2	density	density	NN
cord-306921-3afgpunj	130	3	lipoprotein	lipoprotein	NN
cord-306921-3afgpunj	130	4	receptor	receptor	NN
cord-306921-3afgpunj	130	5	(	(	-LRB-
cord-306921-3afgpunj	130	6	LDLR	LDLR	NNP
cord-306921-3afgpunj	130	7	)	)	-RRB-
cord-306921-3afgpunj	130	8	was	be	VBD
cord-306921-3afgpunj	130	9	purified	purify	VBN
cord-306921-3afgpunj	130	10	by	by	IN
cord-306921-3afgpunj	130	11	Hofer	Hofer	NNP
cord-306921-3afgpunj	130	12	and	and	CC
cord-306921-3afgpunj	130	13	coworkers	coworker	NNS
cord-306921-3afgpunj	130	14	from	from	IN
cord-306921-3afgpunj	130	15	HeLa	HeLa	NNP
cord-306921-3afgpunj	130	16	cell	cell	NN
cord-306921-3afgpunj	130	17	culture	culture	NN
cord-306921-3afgpunj	130	18	supernatant	supernatant	JJ
cord-306921-3afgpunj	130	19	and	and	CC
cord-306921-3afgpunj	130	20	classified	classify	VBN
cord-306921-3afgpunj	130	21	as	as	IN
cord-306921-3afgpunj	130	22	minor	minor	JJ
cord-306921-3afgpunj	130	23	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	130	24	receptor	receptor	NN
cord-306921-3afgpunj	130	25	[	[	-LRB-
cord-306921-3afgpunj	130	26	71	71	CD
cord-306921-3afgpunj	130	27	]	]	-RRB-
cord-306921-3afgpunj	130	28	.	.	.
cord-306921-3afgpunj	131	1	Very	very	RB
cord-306921-3afgpunj	131	2	low	low	JJ
cord-306921-3afgpunj	131	3	lipoprotein	lipoprotein	NN
cord-306921-3afgpunj	131	4	receptor	receptor	NN
cord-306921-3afgpunj	131	5	was	be	VBD
cord-306921-3afgpunj	131	6	also	also	RB
cord-306921-3afgpunj	131	7	identified	identify	VBN
cord-306921-3afgpunj	131	8	to	to	TO
cord-306921-3afgpunj	131	9	be	be	VB
cord-306921-3afgpunj	131	10	a	a	DT
cord-306921-3afgpunj	131	11	receptor	receptor	NN
cord-306921-3afgpunj	131	12	of	of	IN
cord-306921-3afgpunj	131	13	the	the	DT
cord-306921-3afgpunj	131	14	human	human	JJ
cord-306921-3afgpunj	131	15	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	131	16	2(HRV2	2(hrv2	CD
cord-306921-3afgpunj	131	17	)	)	-RRB-
cord-306921-3afgpunj	132	1	[	[	-LRB-
cord-306921-3afgpunj	132	2	72	72	CD
cord-306921-3afgpunj	132	3	]	]	-RRB-
cord-306921-3afgpunj	132	4	.	.	.
cord-306921-3afgpunj	133	1	Intercellular	intercellular	JJ
cord-306921-3afgpunj	133	2	adhesion	adhesion	NN
cord-306921-3afgpunj	133	3	molecule-1	molecule-1	NNP
cord-306921-3afgpunj	133	4	(	(	-LRB-
cord-306921-3afgpunj	133	5	ICAM-1	ICAM-1	NNP
cord-306921-3afgpunj	133	6	)	)	-RRB-
cord-306921-3afgpunj	133	7	was	be	VBD
cord-306921-3afgpunj	133	8	also	also	RB
cord-306921-3afgpunj	133	9	observed	observe	VBN
cord-306921-3afgpunj	133	10	to	to	TO
cord-306921-3afgpunj	133	11	be	be	VB
cord-306921-3afgpunj	133	12	aiding	aid	VBG
cord-306921-3afgpunj	133	13	infection	infection	NN
cord-306921-3afgpunj	133	14	of	of	IN
cord-306921-3afgpunj	133	15	mouse	mouse	NN
cord-306921-3afgpunj	133	16	cells	cell	NNS
cord-306921-3afgpunj	133	17	by	by	IN
cord-306921-3afgpunj	133	18	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	133	19	A21	A21	NNP
cord-306921-3afgpunj	133	20	and	and	CC
cord-306921-3afgpunj	133	21	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	133	22	thereby	thereby	RB
cord-306921-3afgpunj	133	23	acting	act	VBG
cord-306921-3afgpunj	133	24	as	as	IN
cord-306921-3afgpunj	133	25	its	-PRON-	PRP$
cord-306921-3afgpunj	133	26	receptor	receptor	NN
cord-306921-3afgpunj	133	27	[	[	-LRB-
cord-306921-3afgpunj	133	28	46	46	CD
cord-306921-3afgpunj	133	29	,	,	,
cord-306921-3afgpunj	133	30	73	73	CD
cord-306921-3afgpunj	133	31	]	]	-RRB-
cord-306921-3afgpunj	133	32	.	.	.
cord-306921-3afgpunj	134	1	Another	another	DT
cord-306921-3afgpunj	134	2	host	host	NN
cord-306921-3afgpunj	134	3	factor	factor	NN
cord-306921-3afgpunj	134	4	;	;	:
cord-306921-3afgpunj	134	5	KREMEN1	KREMEN1	NNP
cord-306921-3afgpunj	134	6	was	be	VBD
cord-306921-3afgpunj	134	7	recently	recently	RB
cord-306921-3afgpunj	134	8	shown	show	VBN
cord-306921-3afgpunj	134	9	to	to	TO
cord-306921-3afgpunj	134	10	play	play	VB
cord-306921-3afgpunj	134	11	a	a	DT
cord-306921-3afgpunj	134	12	role	role	NN
cord-306921-3afgpunj	134	13	in	in	IN
cord-306921-3afgpunj	134	14	the	the	DT
cord-306921-3afgpunj	134	15	entry	entry	NN
cord-306921-3afgpunj	134	16	of	of	IN
cord-306921-3afgpunj	134	17	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	134	18	A10	A10	NNP
cord-306921-3afgpunj	134	19	(	(	-LRB-
cord-306921-3afgpunj	134	20	CV	CV	NNP
cord-306921-3afgpunj	134	21	-	-	HYPH
cord-306921-3afgpunj	134	22	A10	A10	NNP
cord-306921-3afgpunj	134	23	)	)	-RRB-
cord-306921-3afgpunj	134	24	;	;	:
cord-306921-3afgpunj	134	25	serotype	serotype	NN
cord-306921-3afgpunj	134	26	A	a	DT
cord-306921-3afgpunj	134	27	enterovirus	enterovirus	NN
cord-306921-3afgpunj	134	28	[	[	-LRB-
cord-306921-3afgpunj	134	29	74	74	CD
cord-306921-3afgpunj	134	30	]	]	-RRB-
cord-306921-3afgpunj	134	31	.	.	.
cord-306921-3afgpunj	135	1	This	this	DT
cord-306921-3afgpunj	135	2	study	study	NN
cord-306921-3afgpunj	135	3	also	also	RB
cord-306921-3afgpunj	135	4	showed	show	VBD
cord-306921-3afgpunj	135	5	that	that	IN
cord-306921-3afgpunj	135	6	KREMEN1	kremen1	NN
cord-306921-3afgpunj	135	7	played	play	VBD
cord-306921-3afgpunj	135	8	a	a	DT
cord-306921-3afgpunj	135	9	major	major	JJ
cord-306921-3afgpunj	135	10	role	role	NN
cord-306921-3afgpunj	135	11	in	in	IN
cord-306921-3afgpunj	135	12	entry	entry	NN
cord-306921-3afgpunj	135	13	of	of	IN
cord-306921-3afgpunj	135	14	other	other	JJ
cord-306921-3afgpunj	135	15	serotype	serotype	NN
cord-306921-3afgpunj	135	16	A	a	DT
cord-306921-3afgpunj	135	17	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	135	18	;	;	:
cord-306921-3afgpunj	135	19	A2	A2	NNP
cord-306921-3afgpunj	135	20	,	,	,
cord-306921-3afgpunj	135	21	A3	A3	NNP
cord-306921-3afgpunj	135	22	,	,	,
cord-306921-3afgpunj	135	23	A4	A4	NNP
cord-306921-3afgpunj	135	24	,	,	,
cord-306921-3afgpunj	135	25	A5	A5	NNP
cord-306921-3afgpunj	135	26	,	,	,
cord-306921-3afgpunj	135	27	A6	A6	NNP
cord-306921-3afgpunj	135	28	and	and	CC
cord-306921-3afgpunj	135	29	A12	A12	NNP
cord-306921-3afgpunj	135	30	[	[	-LRB-
cord-306921-3afgpunj	135	31	74	74	CD
cord-306921-3afgpunj	135	32	]	]	-RRB-
cord-306921-3afgpunj	135	33	.	.	.
cord-306921-3afgpunj	136	1	Interestingly	interestingly	RB
cord-306921-3afgpunj	136	2	sequence	sequence	NN
cord-306921-3afgpunj	136	3	analysis	analysis	NN
cord-306921-3afgpunj	136	4	of	of	IN
cord-306921-3afgpunj	136	5	these	these	DT
cord-306921-3afgpunj	136	6	viruses	virus	NNS
cord-306921-3afgpunj	136	7	using	use	VBG
cord-306921-3afgpunj	136	8	the	the	DT
cord-306921-3afgpunj	136	9	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	136	10	structural	structural	JJ
cord-306921-3afgpunj	136	11	protein	protein	NN
cord-306921-3afgpunj	136	12	P1	P1	NNP
cord-306921-3afgpunj	136	13	showed	show	VBD
cord-306921-3afgpunj	136	14	that	that	IN
cord-306921-3afgpunj	136	15	they	-PRON-	PRP
cord-306921-3afgpunj	136	16	cluster	cluster	VBP
cord-306921-3afgpunj	136	17	together	together	RB
cord-306921-3afgpunj	136	18	on	on	IN
cord-306921-3afgpunj	136	19	the	the	DT
cord-306921-3afgpunj	136	20	phylogenetic	phylogenetic	JJ
cord-306921-3afgpunj	136	21	tree	tree	NN
cord-306921-3afgpunj	136	22	.	.	.
cord-306921-3afgpunj	137	1	Studies	study	NNS
cord-306921-3afgpunj	137	2	on	on	IN
cord-306921-3afgpunj	137	3	another	another	DT
cord-306921-3afgpunj	137	4	enterovirus	enterovirus	NN
cord-306921-3afgpunj	137	5	;	;	:
cord-306921-3afgpunj	137	6	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	137	7	C	C	NNP
cord-306921-3afgpunj	137	8	(	(	-LRB-
cord-306921-3afgpunj	137	9	RV	RV	NNP
cord-306921-3afgpunj	137	10	-	-	HYPH
cord-306921-3afgpunj	137	11	C	C	NNP
cord-306921-3afgpunj	137	12	)	)	-RRB-
cord-306921-3afgpunj	137	13	,	,	,
cord-306921-3afgpunj	137	14	associated	associate	VBN
cord-306921-3afgpunj	137	15	with	with	IN
cord-306921-3afgpunj	137	16	severe	severe	JJ
cord-306921-3afgpunj	137	17	respiratory	respiratory	JJ
cord-306921-3afgpunj	137	18	diseases	disease	NNS
cord-306921-3afgpunj	137	19	,	,	,
cord-306921-3afgpunj	137	20	wheezing	wheeze	VBG
cord-306921-3afgpunj	137	21	and	and	CC
cord-306921-3afgpunj	137	22	asthmas	asthmas	NN
cord-306921-3afgpunj	137	23	in	in	IN
cord-306921-3afgpunj	137	24	children	child	NNS
cord-306921-3afgpunj	137	25	has	have	VBZ
cord-306921-3afgpunj	137	26	been	be	VBN
cord-306921-3afgpunj	137	27	limited	limit	VBN
cord-306921-3afgpunj	137	28	by	by	IN
cord-306921-3afgpunj	137	29	the	the	DT
cord-306921-3afgpunj	137	30	inability	inability	NN
cord-306921-3afgpunj	137	31	to	to	TO
cord-306921-3afgpunj	137	32	grow	grow	VB
cord-306921-3afgpunj	137	33	in	in	IN
cord-306921-3afgpunj	137	34	cell	cell	NN
cord-306921-3afgpunj	137	35	cultures	culture	NNS
cord-306921-3afgpunj	137	36	.	.	.
cord-306921-3afgpunj	138	1	However	however	RB
cord-306921-3afgpunj	138	2	a	a	DT
cord-306921-3afgpunj	138	3	recent	recent	JJ
cord-306921-3afgpunj	138	4	study	study	NN
cord-306921-3afgpunj	138	5	identified	identify	VBD
cord-306921-3afgpunj	138	6	human	human	JJ
cord-306921-3afgpunj	138	7	clathrin	clathrin	NN
cord-306921-3afgpunj	138	8	related	relate	VBN
cord-306921-3afgpunj	138	9	family	family	NN
cord-306921-3afgpunj	138	10	member	member	NN
cord-306921-3afgpunj	138	11	3	3	CD
cord-306921-3afgpunj	138	12	(	(	-LRB-
cord-306921-3afgpunj	138	13	CDHR3	cdhr3	UH
cord-306921-3afgpunj	138	14	)	)	-RRB-
cord-306921-3afgpunj	138	15	as	as	IN
cord-306921-3afgpunj	138	16	a	a	DT
cord-306921-3afgpunj	138	17	functional	functional	JJ
cord-306921-3afgpunj	138	18	receptor	receptor	NN
cord-306921-3afgpunj	138	19	for	for	IN
cord-306921-3afgpunj	138	20	the	the	DT
cord-306921-3afgpunj	138	21	RV	RV	NNP
cord-306921-3afgpunj	138	22	-	-	HYPH
cord-306921-3afgpunj	138	23	C	C	NNP
cord-306921-3afgpunj	138	24	[	[	-LRB-
cord-306921-3afgpunj	138	25	75	75	CD
cord-306921-3afgpunj	138	26	]	]	-RRB-
cord-306921-3afgpunj	138	27	.	.	.
cord-306921-3afgpunj	139	1	Receptors	receptor	NNS
cord-306921-3afgpunj	139	2	for	for	IN
cord-306921-3afgpunj	139	3	both	both	CC
cord-306921-3afgpunj	139	4	the	the	DT
cord-306921-3afgpunj	139	5	major	major	JJ
cord-306921-3afgpunj	139	6	group	group	NN
cord-306921-3afgpunj	139	7	of	of	IN
cord-306921-3afgpunj	139	8	rhinoviruses	rhinovirus	NNS
cord-306921-3afgpunj	139	9	A	A	NNP
cord-306921-3afgpunj	139	10	and	and	CC
cord-306921-3afgpunj	139	11	B	B	NNP
cord-306921-3afgpunj	139	12	have	have	VBP
cord-306921-3afgpunj	139	13	been	be	VBN
cord-306921-3afgpunj	139	14	described	describe	VBN
cord-306921-3afgpunj	139	15	.	.	.
cord-306921-3afgpunj	140	1	Major	major	JJ
cord-306921-3afgpunj	140	2	group	group	NN
cord-306921-3afgpunj	140	3	of	of	IN
cord-306921-3afgpunj	140	4	rhinovirus	rhinovirus	NNP
cord-306921-3afgpunj	140	5	A	A	NNP
cord-306921-3afgpunj	140	6	and	and	CC
cord-306921-3afgpunj	140	7	B	B	NNP
cord-306921-3afgpunj	140	8	(	(	-LRB-
cord-306921-3afgpunj	140	9	RV	RV	NNP
cord-306921-3afgpunj	140	10	-	-	HYPH
cord-306921-3afgpunj	140	11	A	A	NNP
cord-306921-3afgpunj	140	12	and	and	CC
cord-306921-3afgpunj	140	13	RV	rv	NN
cord-306921-3afgpunj	140	14	-	-	HYPH
cord-306921-3afgpunj	140	15	B	b	NN
cord-306921-3afgpunj	140	16	)	)	-RRB-
cord-306921-3afgpunj	140	17	binds	bind	VBZ
cord-306921-3afgpunj	140	18	to	to	IN
cord-306921-3afgpunj	140	19	the	the	DT
cord-306921-3afgpunj	140	20	intercellular	intercellular	JJ
cord-306921-3afgpunj	140	21	adhesive	adhesive	NN
cord-306921-3afgpunj	140	22	molecule	molecule	NN
cord-306921-3afgpunj	140	23	(	(	-LRB-
cord-306921-3afgpunj	140	24	ICAM-1	ICAM-1	NNP
cord-306921-3afgpunj	140	25	)	)	-RRB-
cord-306921-3afgpunj	141	1	[	[	-LRB-
cord-306921-3afgpunj	141	2	46	46	CD
cord-306921-3afgpunj	141	3	]	]	-RRB-
cord-306921-3afgpunj	141	4	while	while	IN
cord-306921-3afgpunj	141	5	the	the	DT
cord-306921-3afgpunj	141	6	minor	minor	JJ
cord-306921-3afgpunj	141	7	group	group	NN
cord-306921-3afgpunj	141	8	binds	bind	VBZ
cord-306921-3afgpunj	141	9	to	to	IN
cord-306921-3afgpunj	141	10	the	the	DT
cord-306921-3afgpunj	141	11	low	low	JJ
cord-306921-3afgpunj	141	12	density	density	NN
cord-306921-3afgpunj	141	13	lipoprotein	lipoprotein	NN
cord-306921-3afgpunj	141	14	for	for	IN
cord-306921-3afgpunj	141	15	efficient	efficient	JJ
cord-306921-3afgpunj	141	16	entry	entry	NN
cord-306921-3afgpunj	141	17	into	into	IN
cord-306921-3afgpunj	141	18	the	the	DT
cord-306921-3afgpunj	141	19	cells	cell	NNS
cord-306921-3afgpunj	141	20	[	[	-LRB-
cord-306921-3afgpunj	141	21	71	71	CD
cord-306921-3afgpunj	141	22	,	,	,
cord-306921-3afgpunj	141	23	76	76	CD
cord-306921-3afgpunj	141	24	]	]	-RRB-
cord-306921-3afgpunj	141	25	.	.	.
cord-306921-3afgpunj	142	1	Identification	identification	NN
cord-306921-3afgpunj	142	2	of	of	IN
cord-306921-3afgpunj	142	3	receptors	receptor	NNS
cord-306921-3afgpunj	142	4	for	for	IN
cord-306921-3afgpunj	142	5	the	the	DT
cord-306921-3afgpunj	142	6	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	142	7	enables	enable	VBZ
cord-306921-3afgpunj	142	8	us	-PRON-	PRP
cord-306921-3afgpunj	142	9	to	to	TO
cord-306921-3afgpunj	142	10	understand	understand	VB
cord-306921-3afgpunj	142	11	the	the	DT
cord-306921-3afgpunj	142	12	pathogenicity	pathogenicity	NN
cord-306921-3afgpunj	142	13	of	of	IN
cord-306921-3afgpunj	142	14	these	these	DT
cord-306921-3afgpunj	142	15	epidemiologically	epidemiologically	RB
cord-306921-3afgpunj	142	16	important	important	JJ
cord-306921-3afgpunj	142	17	group	group	NN
cord-306921-3afgpunj	142	18	of	of	IN
cord-306921-3afgpunj	142	19	viruses	virus	NNS
cord-306921-3afgpunj	142	20	.	.	.
cord-306921-3afgpunj	143	1	Attachment	attachment	NN
cord-306921-3afgpunj	143	2	,	,	,
cord-306921-3afgpunj	143	3	adsorption	adsorption	NN
cord-306921-3afgpunj	143	4	and	and	CC
cord-306921-3afgpunj	143	5	entry	entry	NN
cord-306921-3afgpunj	143	6	of	of	IN
cord-306921-3afgpunj	143	7	viruses	virus	NNS
cord-306921-3afgpunj	143	8	into	into	IN
cord-306921-3afgpunj	143	9	the	the	DT
cord-306921-3afgpunj	143	10	cells	cell	NNS
cord-306921-3afgpunj	143	11	are	be	VBP
cord-306921-3afgpunj	143	12	the	the	DT
cord-306921-3afgpunj	143	13	key	key	JJ
cord-306921-3afgpunj	143	14	initial	initial	JJ
cord-306921-3afgpunj	143	15	stages	stage	NNS
cord-306921-3afgpunj	143	16	for	for	IN
cord-306921-3afgpunj	143	17	establishing	establish	VBG
cord-306921-3afgpunj	143	18	efficient	efficient	JJ
cord-306921-3afgpunj	143	19	viral	viral	JJ
cord-306921-3afgpunj	143	20	infections	infection	NNS
cord-306921-3afgpunj	143	21	.	.	.
cord-306921-3afgpunj	144	1	There	there	EX
cord-306921-3afgpunj	144	2	is	be	VBZ
cord-306921-3afgpunj	144	3	need	need	NN
cord-306921-3afgpunj	144	4	to	to	TO
cord-306921-3afgpunj	144	5	understand	understand	VB
cord-306921-3afgpunj	144	6	the	the	DT
cord-306921-3afgpunj	144	7	infection	infection	NN
cord-306921-3afgpunj	144	8	-	-	HYPH
cord-306921-3afgpunj	144	9	mics	mic	NNS
cord-306921-3afgpunj	144	10	of	of	IN
cord-306921-3afgpunj	144	11	the	the	DT
cord-306921-3afgpunj	144	12	rhinoviruses	rhinovirus	NNS
cord-306921-3afgpunj	144	13	with	with	IN
cord-306921-3afgpunj	144	14	a	a	DT
cord-306921-3afgpunj	144	15	goal	goal	NN
cord-306921-3afgpunj	144	16	of	of	IN
cord-306921-3afgpunj	144	17	developing	develop	VBG
cord-306921-3afgpunj	144	18	antivirals	antiviral	NNS
cord-306921-3afgpunj	144	19	or	or	CC
cord-306921-3afgpunj	144	20	vaccines	vaccine	NNS
cord-306921-3afgpunj	144	21	towards	towards	IN
cord-306921-3afgpunj	144	22	this	this	DT
cord-306921-3afgpunj	144	23	group	group	NN
cord-306921-3afgpunj	144	24	of	of	IN
cord-306921-3afgpunj	144	25	viruses	virus	NNS
cord-306921-3afgpunj	144	26	.	.	.
cord-306921-3afgpunj	145	1	For	for	IN
cord-306921-3afgpunj	145	2	echoviruses	echovirus	NNS
cord-306921-3afgpunj	145	3	;	;	:
cord-306921-3afgpunj	145	4	decay	decay	VB
cord-306921-3afgpunj	145	5	accelerating	accelerate	VBG
cord-306921-3afgpunj	145	6	factor	factor	NN
cord-306921-3afgpunj	145	7	(	(	-LRB-
cord-306921-3afgpunj	145	8	DAF	DAF	NNP
cord-306921-3afgpunj	145	9	)	)	-RRB-
cord-306921-3afgpunj	145	10	;	;	:
cord-306921-3afgpunj	145	11	CD55	CD55	NNP
cord-306921-3afgpunj	145	12	known	know	VBN
cord-306921-3afgpunj	145	13	to	to	TO
cord-306921-3afgpunj	145	14	regulate	regulate	VB
cord-306921-3afgpunj	145	15	complement	complement	NN
cord-306921-3afgpunj	145	16	system	system	NN
cord-306921-3afgpunj	145	17	within	within	IN
cord-306921-3afgpunj	145	18	cells	cell	NNS
cord-306921-3afgpunj	145	19	was	be	VBD
cord-306921-3afgpunj	145	20	also	also	RB
cord-306921-3afgpunj	145	21	shown	show	VBN
cord-306921-3afgpunj	145	22	to	to	TO
cord-306921-3afgpunj	145	23	be	be	VB
cord-306921-3afgpunj	145	24	a	a	DT
cord-306921-3afgpunj	145	25	receptor	receptor	NN
cord-306921-3afgpunj	145	26	for	for	IN
cord-306921-3afgpunj	145	27	a	a	DT
cord-306921-3afgpunj	145	28	number	number	NN
cord-306921-3afgpunj	145	29	of	of	IN
cord-306921-3afgpunj	145	30	echoviruses	echovirus	NNS
cord-306921-3afgpunj	145	31	and	and	CC
cord-306921-3afgpunj	145	32	coxsackie	coxsackie	NNP
cord-306921-3afgpunj	145	33	B	B	NNP
cord-306921-3afgpunj	145	34	viruses	virus	NNS
cord-306921-3afgpunj	145	35	[	[	-LRB-
cord-306921-3afgpunj	145	36	77	77	CD
cord-306921-3afgpunj	145	37	]	]	-RRB-
cord-306921-3afgpunj	145	38	[	[	-LRB-
cord-306921-3afgpunj	145	39	78	78	CD
cord-306921-3afgpunj	145	40	]	]	-RRB-
cord-306921-3afgpunj	145	41	[	[	-LRB-
cord-306921-3afgpunj	145	42	79	79	CD
cord-306921-3afgpunj	145	43	]	]	-RRB-
cord-306921-3afgpunj	145	44	.	.	.
cord-306921-3afgpunj	146	1	Known	know	VBN
cord-306921-3afgpunj	146	2	NPEV	NPEV	NNP
cord-306921-3afgpunj	146	3	receptors	receptor	NNS
cord-306921-3afgpunj	146	4	are	be	VBP
cord-306921-3afgpunj	146	5	summarized	summarize	VBN
cord-306921-3afgpunj	146	6	in	in	IN
cord-306921-3afgpunj	146	7	Table	Table	NNP
cord-306921-3afgpunj	146	8	1	1	CD
cord-306921-3afgpunj	146	9	below	below	RB
cord-306921-3afgpunj	146	10	.	.	.
cord-306921-3afgpunj	147	1	Clearly	clearly	RB
cord-306921-3afgpunj	147	2	dissecting	dissect	VBG
cord-306921-3afgpunj	147	3	the	the	DT
cord-306921-3afgpunj	147	4	human	human	JJ
cord-306921-3afgpunj	147	5	host	host	NN
cord-306921-3afgpunj	147	6	cell	cell	NN
cord-306921-3afgpunj	147	7	factors	factor	NNS
cord-306921-3afgpunj	147	8	-	-	:
cord-306921-3afgpunj	147	9	NPEV	NPEV	NNP
cord-306921-3afgpunj	147	10	interactions	interaction	NNS
cord-306921-3afgpunj	147	11	will	will	MD
cord-306921-3afgpunj	147	12	provide	provide	VB
cord-306921-3afgpunj	147	13	a	a	DT
cord-306921-3afgpunj	147	14	rich	rich	JJ
cord-306921-3afgpunj	147	15	niche	niche	NN
cord-306921-3afgpunj	147	16	of	of	IN
cord-306921-3afgpunj	147	17	interaction	interaction	NN
cord-306921-3afgpunj	147	18	map	map	NN
cord-306921-3afgpunj	147	19	that	that	WDT
cord-306921-3afgpunj	147	20	will	will	MD
cord-306921-3afgpunj	147	21	be	be	VB
cord-306921-3afgpunj	147	22	key	key	JJ
cord-306921-3afgpunj	147	23	in	in	IN
cord-306921-3afgpunj	147	24	the	the	DT
cord-306921-3afgpunj	147	25	design	design	NN
cord-306921-3afgpunj	147	26	of	of	IN
cord-306921-3afgpunj	147	27	antiviral	antiviral	JJ
cord-306921-3afgpunj	147	28	therapy	therapy	NN
cord-306921-3afgpunj	147	29	against	against	IN
cord-306921-3afgpunj	147	30	this	this	DT
cord-306921-3afgpunj	147	31	group	group	NN
cord-306921-3afgpunj	147	32	of	of	IN
cord-306921-3afgpunj	147	33	epidemiological	epidemiological	JJ
cord-306921-3afgpunj	147	34	importance	importance	NN
cord-306921-3afgpunj	147	35	.	.	.
cord-306921-3afgpunj	148	1	Understanding	understand	VBG
cord-306921-3afgpunj	148	2	the	the	DT
cord-306921-3afgpunj	148	3	mechanisms	mechanism	NNS
cord-306921-3afgpunj	148	4	involved	involve	VBN
cord-306921-3afgpunj	148	5	in	in	IN
cord-306921-3afgpunj	148	6	viral	viral	JJ
cord-306921-3afgpunj	148	7	entry	entry	NN
cord-306921-3afgpunj	148	8	as	as	RB
cord-306921-3afgpunj	148	9	well	well	RB
cord-306921-3afgpunj	148	10	as	as	IN
cord-306921-3afgpunj	148	11	the	the	DT
cord-306921-3afgpunj	148	12	host	host	NN
cord-306921-3afgpunj	148	13	cell	cell	NN
cord-306921-3afgpunj	148	14	factors	factor	NNS
cord-306921-3afgpunj	148	15	acting	act	VBG
cord-306921-3afgpunj	148	16	as	as	IN
cord-306921-3afgpunj	148	17	receptors	receptor	NNS
cord-306921-3afgpunj	148	18	will	will	MD
cord-306921-3afgpunj	148	19	provide	provide	VB
cord-306921-3afgpunj	148	20	important	important	JJ
cord-306921-3afgpunj	148	21	information	information	NN
cord-306921-3afgpunj	148	22	on	on	IN
cord-306921-3afgpunj	148	23	the	the	DT
cord-306921-3afgpunj	148	24	development	development	NN
cord-306921-3afgpunj	148	25	of	of	IN
cord-306921-3afgpunj	148	26	viral	viral	JJ
cord-306921-3afgpunj	148	27	entry	entry	NN
cord-306921-3afgpunj	148	28	inhibitors	inhibitor	NNS
cord-306921-3afgpunj	148	29	.	.	.
cord-306921-3afgpunj	149	1	Given	give	VBN
cord-306921-3afgpunj	149	2	that	that	IN
cord-306921-3afgpunj	149	3	most	most	JJS
cord-306921-3afgpunj	149	4	of	of	IN
cord-306921-3afgpunj	149	5	these	these	DT
cord-306921-3afgpunj	149	6	viruses	virus	NNS
cord-306921-3afgpunj	149	7	use	use	VBP
cord-306921-3afgpunj	149	8	an	an	DT
cord-306921-3afgpunj	149	9	array	array	NN
cord-306921-3afgpunj	149	10	of	of	IN
cord-306921-3afgpunj	149	11	host	host	NN
cord-306921-3afgpunj	149	12	factors	factor	NNS
cord-306921-3afgpunj	149	13	/	/	SYM
cord-306921-3afgpunj	149	14	mechanisms	mechanism	NNS
cord-306921-3afgpunj	149	15	to	to	TO
cord-306921-3afgpunj	149	16	infect	infect	VB
cord-306921-3afgpunj	149	17	the	the	DT
cord-306921-3afgpunj	149	18	host	host	NN
cord-306921-3afgpunj	149	19	cell	cell	NN
cord-306921-3afgpunj	149	20	,	,	,
cord-306921-3afgpunj	149	21	as	as	IN
cord-306921-3afgpunj	149	22	blocking	block	VBG
cord-306921-3afgpunj	149	23	of	of	IN
cord-306921-3afgpunj	149	24	known	know	VBN
cord-306921-3afgpunj	149	25	entry	entry	NN
cord-306921-3afgpunj	149	26	inhibitors	inhibitor	NNS
cord-306921-3afgpunj	149	27	do	do	VBP
cord-306921-3afgpunj	149	28	not	not	RB
cord-306921-3afgpunj	149	29	completely	completely	RB
cord-306921-3afgpunj	149	30	inhibit	inhibit	VB
cord-306921-3afgpunj	149	31	viral	viral	JJ
cord-306921-3afgpunj	149	32	entry	entry	NN
cord-306921-3afgpunj	149	33	into	into	IN
cord-306921-3afgpunj	149	34	the	the	DT
cord-306921-3afgpunj	149	35	cells	cell	NNS
cord-306921-3afgpunj	149	36	.	.	.
cord-306921-3afgpunj	150	1	This	this	DT
cord-306921-3afgpunj	150	2	supports	support	VBZ
cord-306921-3afgpunj	150	3	the	the	DT
cord-306921-3afgpunj	150	4	need	need	NN
cord-306921-3afgpunj	150	5	to	to	TO
cord-306921-3afgpunj	150	6	clearly	clearly	RB
cord-306921-3afgpunj	150	7	elucidate	elucidate	VB
cord-306921-3afgpunj	150	8	and	and	CC
cord-306921-3afgpunj	150	9	map	map	VB
cord-306921-3afgpunj	150	10	out	out	RP
cord-306921-3afgpunj	150	11	all	all	DT
cord-306921-3afgpunj	150	12	host	host	NN
cord-306921-3afgpunj	150	13	factors	factor	NNS
cord-306921-3afgpunj	150	14	involved	involve	VBN
cord-306921-3afgpunj	150	15	in	in	IN
cord-306921-3afgpunj	150	16	the	the	DT
cord-306921-3afgpunj	150	17	viral	viral	JJ
cord-306921-3afgpunj	150	18	attachment	attachment	NN
cord-306921-3afgpunj	150	19	and	and	CC
cord-306921-3afgpunj	150	20	eventual	eventual	JJ
cord-306921-3afgpunj	150	21	entry	entry	NN
cord-306921-3afgpunj	150	22	.	.	.
cord-306921-3afgpunj	151	1	This	this	DT
cord-306921-3afgpunj	151	2	interaction	interaction	NN
cord-306921-3afgpunj	151	3	between	between	IN
cord-306921-3afgpunj	151	4	human	human	JJ
cord-306921-3afgpunj	151	5	host	host	NN
cord-306921-3afgpunj	151	6	factors	factor	NNS
cord-306921-3afgpunj	151	7	and	and	CC
cord-306921-3afgpunj	151	8	viral	viral	JJ
cord-306921-3afgpunj	151	9	proteins	protein	NNS
cord-306921-3afgpunj	151	10	for	for	IN
cord-306921-3afgpunj	151	11	eventual	eventual	JJ
cord-306921-3afgpunj	151	12	entry	entry	NN
cord-306921-3afgpunj	151	13	into	into	IN
cord-306921-3afgpunj	151	14	the	the	DT
cord-306921-3afgpunj	151	15	cells	cell	NNS
cord-306921-3afgpunj	151	16	plays	play	VBZ
cord-306921-3afgpunj	151	17	the	the	DT
cord-306921-3afgpunj	151	18	key	key	JJ
cord-306921-3afgpunj	151	19	role	role	NN
cord-306921-3afgpunj	151	20	in	in	IN
cord-306921-3afgpunj	151	21	the	the	DT
cord-306921-3afgpunj	151	22	viral	viral	JJ
cord-306921-3afgpunj	151	23	tissue	tissue	NN
cord-306921-3afgpunj	151	24	tropism	tropism	NN
cord-306921-3afgpunj	151	25	.	.	.
cord-306921-3afgpunj	152	1	We	-PRON-	PRP
cord-306921-3afgpunj	152	2	therefore	therefore	RB
cord-306921-3afgpunj	152	3	suggest	suggest	VBP
cord-306921-3afgpunj	152	4	that	that	IN
cord-306921-3afgpunj	152	5	more	more	RBR
cord-306921-3afgpunj	152	6	concerted	concerted	JJ
cord-306921-3afgpunj	152	7	efforts	effort	NNS
cord-306921-3afgpunj	152	8	need	need	VBP
cord-306921-3afgpunj	152	9	to	to	TO
cord-306921-3afgpunj	152	10	be	be	VB
cord-306921-3afgpunj	152	11	put	put	VBN
cord-306921-3afgpunj	152	12	in	in	IN
cord-306921-3afgpunj	152	13	place	place	NN
cord-306921-3afgpunj	152	14	to	to	TO
cord-306921-3afgpunj	152	15	identify	identify	VB
cord-306921-3afgpunj	152	16	all	all	DT
cord-306921-3afgpunj	152	17	possible	possible	JJ
cord-306921-3afgpunj	152	18	entry	entry	NN
cord-306921-3afgpunj	152	19	mechanisms	mechanism	NNS
cord-306921-3afgpunj	152	20	of	of	IN
cord-306921-3afgpunj	152	21	these	these	DT
cord-306921-3afgpunj	152	22	viruses	virus	NNS
cord-306921-3afgpunj	152	23	with	with	IN
cord-306921-3afgpunj	152	24	an	an	DT
cord-306921-3afgpunj	152	25	aim	aim	NN
cord-306921-3afgpunj	152	26	of	of	IN
cord-306921-3afgpunj	152	27	developing	develop	VBG
cord-306921-3afgpunj	152	28	NPEV	NPEV	NNP
cord-306921-3afgpunj	152	29	entry	entry	NN
cord-306921-3afgpunj	152	30	inhibitors	inhibitor	NNS
cord-306921-3afgpunj	152	31	into	into	IN
cord-306921-3afgpunj	152	32	the	the	DT
cord-306921-3afgpunj	152	33	cells	cell	NNS
cord-306921-3afgpunj	152	34	thereby	thereby	RB
cord-306921-3afgpunj	152	35	limiting	limit	VBG
cord-306921-3afgpunj	152	36	viral	viral	JJ
cord-306921-3afgpunj	152	37	infection	infection	NN
cord-306921-3afgpunj	152	38	.	.	.
cord-306921-3afgpunj	153	1	This	this	DT
cord-306921-3afgpunj	153	2	can	can	MD
cord-306921-3afgpunj	153	3	only	only	RB
cord-306921-3afgpunj	153	4	be	be	VB
cord-306921-3afgpunj	153	5	fruitful	fruitful	JJ
cord-306921-3afgpunj	153	6	if	if	IN
cord-306921-3afgpunj	153	7	we	-PRON-	PRP
cord-306921-3afgpunj	153	8	eventually	eventually	RB
cord-306921-3afgpunj	153	9	identify	identify	VBP
cord-306921-3afgpunj	153	10	all	all	PDT
cord-306921-3afgpunj	153	11	the	the	DT
cord-306921-3afgpunj	153	12	host	host	NN
cord-306921-3afgpunj	153	13	factors	factor	NNS
cord-306921-3afgpunj	153	14	needed	need	VBN
cord-306921-3afgpunj	153	15	for	for	IN
cord-306921-3afgpunj	153	16	the	the	DT
cord-306921-3afgpunj	153	17	NPEV	NPEV	NNP
cord-306921-3afgpunj	153	18	entry	entry	NN
cord-306921-3afgpunj	153	19	into	into	IN
cord-306921-3afgpunj	153	20	cells	cell	NNS
cord-306921-3afgpunj	153	21	.	.	.
cord-306921-3afgpunj	154	1	The	the	DT
cord-306921-3afgpunj	154	2	recent	recent	JJ
cord-306921-3afgpunj	154	3	technological	technological	JJ
cord-306921-3afgpunj	154	4	advances	advance	NNS
cord-306921-3afgpunj	154	5	have	have	VBP
cord-306921-3afgpunj	154	6	been	be	VBN
cord-306921-3afgpunj	154	7	essential	essential	JJ
cord-306921-3afgpunj	154	8	in	in	IN
cord-306921-3afgpunj	154	9	high	high	JJ
cord-306921-3afgpunj	154	10	throughput	throughput	NN
cord-306921-3afgpunj	154	11	genome	genome	NN
cord-306921-3afgpunj	154	12	-	-	HYPH
cord-306921-3afgpunj	154	13	wide	wide	JJ
cord-306921-3afgpunj	154	14	screens	screen	NNS
cord-306921-3afgpunj	154	15	aimed	aim	VBN
cord-306921-3afgpunj	154	16	at	at	IN
cord-306921-3afgpunj	154	17	discovery	discovery	NN
cord-306921-3afgpunj	154	18	of	of	IN
cord-306921-3afgpunj	154	19	the	the	DT
cord-306921-3afgpunj	154	20	interplay	interplay	NN
cord-306921-3afgpunj	154	21	between	between	IN
cord-306921-3afgpunj	154	22	human	human	JJ
cord-306921-3afgpunj	154	23	host	host	NN
cord-306921-3afgpunj	154	24	factors	factor	NNS
cord-306921-3afgpunj	154	25	and	and	CC
cord-306921-3afgpunj	154	26	the	the	DT
cord-306921-3afgpunj	154	27	steps	step	NNS
cord-306921-3afgpunj	154	28	involved	involve	VBN
cord-306921-3afgpunj	154	29	in	in	IN
cord-306921-3afgpunj	154	30	viral	viral	JJ
cord-306921-3afgpunj	154	31	infection	infection	NN
cord-306921-3afgpunj	154	32	.	.	.
cord-306921-3afgpunj	155	1	These	these	DT
cord-306921-3afgpunj	155	2	techniques	technique	NNS
cord-306921-3afgpunj	155	3	have	have	VBP
cord-306921-3afgpunj	155	4	revolutionized	revolutionize	VBN
cord-306921-3afgpunj	155	5	the	the	DT
cord-306921-3afgpunj	155	6	identification	identification	NN
cord-306921-3afgpunj	155	7	of	of	IN
cord-306921-3afgpunj	155	8	human	human	JJ
cord-306921-3afgpunj	155	9	host	host	NN
cord-306921-3afgpunj	155	10	factors	factor	NNS
cord-306921-3afgpunj	155	11	involved	involve	VBN
cord-306921-3afgpunj	155	12	in	in	IN
cord-306921-3afgpunj	155	13	viral	viral	JJ
cord-306921-3afgpunj	155	14	infections	infection	NNS
cord-306921-3afgpunj	155	15	with	with	IN
cord-306921-3afgpunj	155	16	much	much	JJ
cord-306921-3afgpunj	155	17	success	success	NN
cord-306921-3afgpunj	155	18	so	so	RB
cord-306921-3afgpunj	155	19	far	far	RB
cord-306921-3afgpunj	155	20	.	.	.
cord-306921-3afgpunj	156	1	Cherry	Cherry	NNP
cord-306921-3afgpunj	156	2	and	and	CC
cord-306921-3afgpunj	156	3	Panda	Panda	NNP
cord-306921-3afgpunj	156	4	presented	present	VBD
cord-306921-3afgpunj	156	5	techniques	technique	NNS
cord-306921-3afgpunj	156	6	for	for	IN
cord-306921-3afgpunj	156	7	siRNA	siRNA	NNP
cord-306921-3afgpunj	156	8	genome	genome	NN
cord-306921-3afgpunj	156	9	-	-	HYPH
cord-306921-3afgpunj	156	10	wide	wide	JJ
cord-306921-3afgpunj	156	11	screens	screen	NNS
cord-306921-3afgpunj	156	12	,	,	,
cord-306921-3afgpunj	156	13	detailing	detail	VBG
cord-306921-3afgpunj	156	14	all	all	PDT
cord-306921-3afgpunj	156	15	the	the	DT
cord-306921-3afgpunj	156	16	basic	basic	JJ
cord-306921-3afgpunj	156	17	steps	step	NNS
cord-306921-3afgpunj	156	18	involved	involve	VBN
cord-306921-3afgpunj	156	19	[	[	-LRB-
cord-306921-3afgpunj	156	20	81	81	CD
cord-306921-3afgpunj	156	21	]	]	-RRB-
cord-306921-3afgpunj	156	22	.	.	.
cord-306921-3afgpunj	157	1	Several	several	JJ
cord-306921-3afgpunj	157	2	studies	study	NNS
cord-306921-3afgpunj	157	3	have	have	VBP
cord-306921-3afgpunj	157	4	used	use	VBN
cord-306921-3afgpunj	157	5	the	the	DT
cord-306921-3afgpunj	157	6	siRNA	siRNA	NNP
cord-306921-3afgpunj	157	7	genome	genome	NN
cord-306921-3afgpunj	157	8	-	-	HYPH
cord-306921-3afgpunj	157	9	wide	wide	JJ
cord-306921-3afgpunj	157	10	screens	screen	NNS
cord-306921-3afgpunj	157	11	to	to	TO
cord-306921-3afgpunj	157	12	identify	identify	VB
cord-306921-3afgpunj	157	13	the	the	DT
cord-306921-3afgpunj	157	14	role	role	NN
cord-306921-3afgpunj	157	15	of	of	IN
cord-306921-3afgpunj	157	16	human	human	JJ
cord-306921-3afgpunj	157	17	host	host	NN
cord-306921-3afgpunj	157	18	factors	factor	NNS
cord-306921-3afgpunj	157	19	during	during	IN
cord-306921-3afgpunj	157	20	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	157	21	infections	infection	NNS
cord-306921-3afgpunj	157	22	.	.	.
cord-306921-3afgpunj	158	1	Wu	Wu	NNP
cord-306921-3afgpunj	158	2	and	and	CC
cord-306921-3afgpunj	158	3	colleagues	colleague	NNS
cord-306921-3afgpunj	158	4	performed	perform	VBD
cord-306921-3afgpunj	158	5	a	a	DT
cord-306921-3afgpunj	158	6	siRNA	siRNA	NNP
cord-306921-3afgpunj	158	7	genome	genome	NN
cord-306921-3afgpunj	158	8	-	-	HYPH
cord-306921-3afgpunj	158	9	wide	wide	JJ
cord-306921-3afgpunj	158	10	screen	screen	NN
cord-306921-3afgpunj	158	11	which	which	WDT
cord-306921-3afgpunj	158	12	identified	identify	VBD
cord-306921-3afgpunj	158	13	several	several	JJ
cord-306921-3afgpunj	158	14	human	human	JJ
cord-306921-3afgpunj	158	15	host	host	NN
cord-306921-3afgpunj	158	16	factors	factor	NNS
cord-306921-3afgpunj	158	17	necessary	necessary	JJ
cord-306921-3afgpunj	158	18	for	for	IN
cord-306921-3afgpunj	158	19	EV	EV	NNP
cord-306921-3afgpunj	158	20	-	-	HYPH
cord-306921-3afgpunj	158	21	A71	A71	NNP
cord-306921-3afgpunj	158	22	virus	virus	NN
cord-306921-3afgpunj	158	23	infection	infection	NN
cord-306921-3afgpunj	158	24	[	[	-LRB-
cord-306921-3afgpunj	158	25	82	82	CD
cord-306921-3afgpunj	158	26	]	]	-RRB-
cord-306921-3afgpunj	158	27	.	.	.
cord-306921-3afgpunj	159	1	This	this	DT
cord-306921-3afgpunj	159	2	study	study	NN
cord-306921-3afgpunj	159	3	identified	identify	VBD
cord-306921-3afgpunj	159	4	susceptible	susceptible	JJ
cord-306921-3afgpunj	159	5	host	host	NN
cord-306921-3afgpunj	159	6	factors	factor	NNS
cord-306921-3afgpunj	159	7	and	and	CC
cord-306921-3afgpunj	159	8	resistant	resistant	JJ
cord-306921-3afgpunj	159	9	host	host	NN
cord-306921-3afgpunj	159	10	factors	factor	NNS
cord-306921-3afgpunj	159	11	involved	involve	VBN
cord-306921-3afgpunj	159	12	in	in	IN
cord-306921-3afgpunj	159	13	EV	EV	NNP
cord-306921-3afgpunj	159	14	-	-	HYPH
cord-306921-3afgpunj	159	15	A71	A71	NNP
cord-306921-3afgpunj	159	16	infection	infection	NN
cord-306921-3afgpunj	159	17	;	;	:
cord-306921-3afgpunj	159	18	NGLY1	NGLY1	NNP
cord-306921-3afgpunj	159	19	and	and	CC
cord-306921-3afgpunj	159	20	CDK6	CDK6	NNP
cord-306921-3afgpunj	159	21	and	and	CC
cord-306921-3afgpunj	159	22	AURKB	AURKB	NNP
cord-306921-3afgpunj	159	23	respectively	respectively	RB
cord-306921-3afgpunj	159	24	pointing	point	VBG
cord-306921-3afgpunj	159	25	to	to	IN
cord-306921-3afgpunj	159	26	an	an	DT
cord-306921-3afgpunj	159	27	important	important	JJ
cord-306921-3afgpunj	159	28	interaction	interaction	NN
cord-306921-3afgpunj	159	29	between	between	IN
cord-306921-3afgpunj	159	30	viral	viral	JJ
cord-306921-3afgpunj	159	31	proteins	protein	NNS
cord-306921-3afgpunj	159	32	and	and	CC
cord-306921-3afgpunj	159	33	human	human	JJ
cord-306921-3afgpunj	159	34	host	host	NN
cord-306921-3afgpunj	159	35	cell	cell	NN
cord-306921-3afgpunj	159	36	factors	factor	NNS
cord-306921-3afgpunj	159	37	.	.	.
cord-306921-3afgpunj	160	1	A	a	DT
cord-306921-3afgpunj	160	2	small	small	JJ
cord-306921-3afgpunj	160	3	siRNA	siRNA	NNP
cord-306921-3afgpunj	160	4	screen	screen	NN
cord-306921-3afgpunj	160	5	targeting	target	VBG
cord-306921-3afgpunj	160	6	human	human	JJ
cord-306921-3afgpunj	160	7	membrane	membrane	NN
cord-306921-3afgpunj	160	8	trafficking	traffic	VBG
cord-306921-3afgpunj	160	9	genes	gene	NNS
cord-306921-3afgpunj	160	10	identified	identify	VBD
cord-306921-3afgpunj	160	11	vasolin	vasolin	NNP
cord-306921-3afgpunj	160	12	-	-	HYPH
cord-306921-3afgpunj	160	13	containing	contain	VBG
cord-306921-3afgpunj	160	14	protein	protein	NN
cord-306921-3afgpunj	160	15	(	(	-LRB-
cord-306921-3afgpunj	160	16	VCP	VCP	NNP
cord-306921-3afgpunj	160	17	-	-	HYPH
cord-306921-3afgpunj	160	18	p97	p97	CD
cord-306921-3afgpunj	160	19	)	)	-RRB-
cord-306921-3afgpunj	160	20	as	as	IN
cord-306921-3afgpunj	160	21	an	an	DT
cord-306921-3afgpunj	160	22	important	important	JJ
cord-306921-3afgpunj	160	23	protein	protein	NN
cord-306921-3afgpunj	160	24	essential	essential	JJ
cord-306921-3afgpunj	160	25	after	after	IN
cord-306921-3afgpunj	160	26	PV	pv	NN
cord-306921-3afgpunj	160	27	viral	viral	JJ
cord-306921-3afgpunj	160	28	replication	replication	NN
cord-306921-3afgpunj	160	29	and	and	CC
cord-306921-3afgpunj	160	30	it	-PRON-	PRP
cord-306921-3afgpunj	160	31	interacts	interact	VBZ
cord-306921-3afgpunj	160	32	and	and	CC
cord-306921-3afgpunj	160	33	colocalizes	colocalize	VBZ
cord-306921-3afgpunj	160	34	with	with	IN
cord-306921-3afgpunj	160	35	2	2	CD
cord-306921-3afgpunj	160	36	BC/2C	BC/2C	NNP
cord-306921-3afgpunj	160	37	as	as	RB
cord-306921-3afgpunj	160	38	well	well	RB
cord-306921-3afgpunj	160	39	as	as	IN
cord-306921-3afgpunj	160	40	3AB/3B	3ab/3b	CD
cord-306921-3afgpunj	160	41	in	in	IN
cord-306921-3afgpunj	160	42	poliovirus	poliovirus	NN
cord-306921-3afgpunj	160	43	infected	infect	VBN
cord-306921-3afgpunj	160	44	cells	cell	NNS
cord-306921-3afgpunj	160	45	[	[	-LRB-
cord-306921-3afgpunj	160	46	83	83	CD
cord-306921-3afgpunj	160	47	]	]	-RRB-
cord-306921-3afgpunj	160	48	.	.	.
cord-306921-3afgpunj	161	1	EV	EV	NNP
cord-306921-3afgpunj	161	2	-	-	HYPH
cord-306921-3afgpunj	161	3	A71	A71	NNP
cord-306921-3afgpunj	161	4	through	through	IN
cord-306921-3afgpunj	161	5	2A	2a	CD
cord-306921-3afgpunj	161	6	pro	pro	NNP
cord-306921-3afgpunj	161	7	and	and	CC
cord-306921-3afgpunj	161	8	3C	3C	NNP
cord-306921-3afgpunj	161	9	pro	pro	NNP
cord-306921-3afgpunj	161	10	have	have	VBP
cord-306921-3afgpunj	161	11	been	be	VBN
cord-306921-3afgpunj	161	12	shown	show	VBN
cord-306921-3afgpunj	161	13	to	to	TO
cord-306921-3afgpunj	161	14	target	target	VB
cord-306921-3afgpunj	161	15	endoplasmic	endoplasmic	NN
cord-306921-3afgpunj	161	16	reticulum	reticulum	NN
cord-306921-3afgpunj	161	17	proteins	protein	NNS
cord-306921-3afgpunj	161	18	thereby	thereby	RB
cord-306921-3afgpunj	161	19	leaving	leave	VBG
cord-306921-3afgpunj	161	20	the	the	DT
cord-306921-3afgpunj	161	21	ERAD	ERAD	NNP
cord-306921-3afgpunj	161	22	proteins	protein	NNS
cord-306921-3afgpunj	161	23	tethered	tether	VBN
cord-306921-3afgpunj	161	24	within	within	IN
cord-306921-3afgpunj	161	25	the	the	DT
cord-306921-3afgpunj	161	26	ER	ER	NNP
cord-306921-3afgpunj	161	27	lumen	lumen	NN
cord-306921-3afgpunj	161	28	[	[	-LRB-
cord-306921-3afgpunj	161	29	84	84	CD
cord-306921-3afgpunj	161	30	]	]	-RRB-
cord-306921-3afgpunj	161	31	.	.	.
cord-306921-3afgpunj	162	1	EV	EV	NNP
cord-306921-3afgpunj	162	2	-	-	HYPH
cord-306921-3afgpunj	162	3	A71	A71	NNP
cord-306921-3afgpunj	162	4	2A	2a	NN
cord-306921-3afgpunj	163	1	pro	pro	JJ
cord-306921-3afgpunj	163	2	specifically	specifically	RB
cord-306921-3afgpunj	163	3	inhibits	inhibit	VBZ
cord-306921-3afgpunj	163	4	synthesis	synthesis	NN
cord-306921-3afgpunj	163	5	of	of	IN
cord-306921-3afgpunj	163	6	Herp	Herp	NNP
cord-306921-3afgpunj	163	7	and	and	CC
cord-306921-3afgpunj	163	8	VIMP	VIMP	NNP
cord-306921-3afgpunj	163	9	at	at	IN
cord-306921-3afgpunj	163	10	the	the	DT
cord-306921-3afgpunj	163	11	translational	translational	JJ
cord-306921-3afgpunj	163	12	level	level	NN
cord-306921-3afgpunj	163	13	,	,	,
cord-306921-3afgpunj	163	14	while	while	IN
cord-306921-3afgpunj	163	15	3C	3C	NNP
cord-306921-3afgpunj	163	16	pro	pro	NNP
cord-306921-3afgpunj	163	17	cleaves	cleave	VBZ
cord-306921-3afgpunj	163	18	Ubc6e	Ubc6e	NNP
cord-306921-3afgpunj	163	19	at	at	IN
cord-306921-3afgpunj	163	20	Q219	Q219	NNPS
cord-306921-3afgpunj	163	21	G	G	NNP
cord-306921-3afgpunj	163	22	,	,	,
cord-306921-3afgpunj	163	23	Q260S	Q260S	NNP
cord-306921-3afgpunj	163	24	,	,	,
cord-306921-3afgpunj	163	25	and	and	CC
cord-306921-3afgpunj	163	26	Q273	Q273	NNP
cord-306921-3afgpunj	163	27	G	G	NNP
cord-306921-3afgpunj	163	28	thereby	thereby	RB
cord-306921-3afgpunj	163	29	interfering	interfere	VBG
cord-306921-3afgpunj	163	30	with	with	IN
cord-306921-3afgpunj	163	31	the	the	DT
cord-306921-3afgpunj	163	32	ERAD	ERAD	NNP
cord-306921-3afgpunj	163	33	processes	process	NNS
cord-306921-3afgpunj	163	34	[	[	-LRB-
cord-306921-3afgpunj	163	35	84	84	CD
cord-306921-3afgpunj	163	36	]	]	-RRB-
cord-306921-3afgpunj	163	37	.	.	.
cord-306921-3afgpunj	164	1	This	this	DT
cord-306921-3afgpunj	164	2	study	study	NN
cord-306921-3afgpunj	164	3	proposed	propose	VBD
cord-306921-3afgpunj	164	4	that	that	IN
cord-306921-3afgpunj	164	5	EV	EV	NNP
cord-306921-3afgpunj	164	6	-	-	HYPH
cord-306921-3afgpunj	164	7	A71	A71	NNP
cord-306921-3afgpunj	164	8	may	may	MD
cord-306921-3afgpunj	164	9	be	be	VB
cord-306921-3afgpunj	164	10	interfering	interfere	VBG
cord-306921-3afgpunj	164	11	with	with	IN
cord-306921-3afgpunj	164	12	the	the	DT
cord-306921-3afgpunj	164	13	ER	ER	NNP
cord-306921-3afgpunj	164	14	membranes	membrane	NNS
cord-306921-3afgpunj	164	15	and	and	CC
cord-306921-3afgpunj	164	16	hijacks	hijack	VBZ
cord-306921-3afgpunj	164	17	ERAD	ERAD	NNP
cord-306921-3afgpunj	164	18	component	component	NN
cord-306921-3afgpunj	164	19	;	;	:
cord-306921-3afgpunj	164	20	p97	p97	CD
cord-306921-3afgpunj	164	21	to	to	TO
cord-306921-3afgpunj	164	22	improve	improve	VB
cord-306921-3afgpunj	164	23	its	-PRON-	PRP$
cord-306921-3afgpunj	164	24	replication	replication	NN
cord-306921-3afgpunj	164	25	[	[	-LRB-
cord-306921-3afgpunj	164	26	84	84	CD
cord-306921-3afgpunj	164	27	]	]	-RRB-
cord-306921-3afgpunj	164	28	.	.	.
cord-306921-3afgpunj	165	1	Pharmacological	pharmacological	JJ
cord-306921-3afgpunj	165	2	inhibition	inhibition	NN
cord-306921-3afgpunj	165	3	of	of	IN
cord-306921-3afgpunj	165	4	myristoyltransferases	myristoyltransferase	NNS
cord-306921-3afgpunj	165	5	resulted	result	VBD
cord-306921-3afgpunj	165	6	in	in	IN
cord-306921-3afgpunj	165	7	a	a	DT
cord-306921-3afgpunj	165	8	decreased	decreased	JJ
cord-306921-3afgpunj	165	9	myristoylation	myristoylation	NN
cord-306921-3afgpunj	165	10	of	of	IN
cord-306921-3afgpunj	165	11	CXB3	CXB3	NNP
cord-306921-3afgpunj	165	12	virus	virus	NN
cord-306921-3afgpunj	165	13	structural	structural	JJ
cord-306921-3afgpunj	165	14	proteins	protein	NNS
cord-306921-3afgpunj	165	15	through	through	IN
cord-306921-3afgpunj	165	16	reduction	reduction	NN
cord-306921-3afgpunj	165	17	of	of	IN
cord-306921-3afgpunj	165	18	VP0	VP0	NNP
cord-306921-3afgpunj	165	19	acylation	acylation	NN
cord-306921-3afgpunj	165	20	[	[	-LRB-
cord-306921-3afgpunj	165	21	85	85	CD
cord-306921-3afgpunj	165	22	]	]	-RRB-
cord-306921-3afgpunj	165	23	.	.	.
cord-306921-3afgpunj	166	1	Inhibition	inhibition	NN
cord-306921-3afgpunj	166	2	of	of	IN
cord-306921-3afgpunj	166	3	myristolyation	myristolyation	NN
cord-306921-3afgpunj	166	4	by	by	IN
cord-306921-3afgpunj	166	5	siRNA	siRNA	NNP
cord-306921-3afgpunj	166	6	knockdown	knockdown	NNP
cord-306921-3afgpunj	166	7	and	and	CC
cord-306921-3afgpunj	166	8	use	use	NN
cord-306921-3afgpunj	166	9	of	of	IN
cord-306921-3afgpunj	166	10	myristic	myristic	JJ
cord-306921-3afgpunj	166	11	acid	acid	JJ
cord-306921-3afgpunj	166	12	analogues	analogue	NNS
cord-306921-3afgpunj	166	13	prevented	prevent	VBD
cord-306921-3afgpunj	166	14	cleavage	cleavage	NN
cord-306921-3afgpunj	166	15	between	between	IN
cord-306921-3afgpunj	166	16	VP4	VP4	NNP
cord-306921-3afgpunj	166	17	and	and	CC
cord-306921-3afgpunj	166	18	VP2	vp2	NN
cord-306921-3afgpunj	166	19	as	as	RB
cord-306921-3afgpunj	166	20	well	well	RB
cord-306921-3afgpunj	166	21	as	as	IN
cord-306921-3afgpunj	166	22	reduction	reduction	NN
cord-306921-3afgpunj	166	23	in	in	IN
cord-306921-3afgpunj	166	24	viral	viral	JJ
cord-306921-3afgpunj	166	25	RNA	RNA	NNP
cord-306921-3afgpunj	166	26	synthesis	synthesis	NN
cord-306921-3afgpunj	166	27	[	[	-LRB-
cord-306921-3afgpunj	166	28	86	86	CD
cord-306921-3afgpunj	166	29	]	]	-RRB-
cord-306921-3afgpunj	166	30	.	.	.
cord-306921-3afgpunj	167	1	These	these	DT
cord-306921-3afgpunj	167	2	studies	study	NNS
cord-306921-3afgpunj	167	3	brings	bring	VBZ
cord-306921-3afgpunj	167	4	forth	forth	RP
cord-306921-3afgpunj	167	5	a	a	DT
cord-306921-3afgpunj	167	6	new	new	JJ
cord-306921-3afgpunj	167	7	mechanism	mechanism	NN
cord-306921-3afgpunj	167	8	of	of	IN
cord-306921-3afgpunj	167	9	myristoylation	myristoylation	NN
cord-306921-3afgpunj	167	10	in	in	IN
cord-306921-3afgpunj	167	11	picornaviral	picornaviral	NNP
cord-306921-3afgpunj	167	12	protein	protein	NNP
cord-306921-3afgpunj	167	13	cleavage	cleavage	NN
cord-306921-3afgpunj	167	14	and	and	CC
cord-306921-3afgpunj	167	15	processing	processing	NN
cord-306921-3afgpunj	167	16	of	of	IN
cord-306921-3afgpunj	167	17	VP0	VP0	NNP
cord-306921-3afgpunj	167	18	thus	thus	RB
cord-306921-3afgpunj	167	19	providing	provide	VBG
cord-306921-3afgpunj	167	20	an	an	DT
cord-306921-3afgpunj	167	21	alternative	alternative	JJ
cord-306921-3afgpunj	167	22	target	target	NN
cord-306921-3afgpunj	167	23	for	for	IN
cord-306921-3afgpunj	167	24	possible	possible	JJ
cord-306921-3afgpunj	167	25	antivirals	antiviral	NNS
cord-306921-3afgpunj	167	26	against	against	IN
cord-306921-3afgpunj	167	27	these	these	DT
cord-306921-3afgpunj	167	28	viruses	virus	NNS
cord-306921-3afgpunj	167	29	[	[	-LRB-
cord-306921-3afgpunj	167	30	85	85	CD
cord-306921-3afgpunj	167	31	]	]	-RRB-
cord-306921-3afgpunj	167	32	.	.	.
cord-306921-3afgpunj	168	1	RNA	RNA	NNP
cord-306921-3afgpunj	168	2	viruses	virus	NNS
cord-306921-3afgpunj	168	3	have	have	VBP
cord-306921-3afgpunj	168	4	evolved	evolve	VBN
cord-306921-3afgpunj	168	5	with	with	IN
cord-306921-3afgpunj	168	6	the	the	DT
cord-306921-3afgpunj	168	7	human	human	JJ
cord-306921-3afgpunj	168	8	host	host	NN
cord-306921-3afgpunj	168	9	cells	cell	NNS
cord-306921-3afgpunj	168	10	to	to	TO
cord-306921-3afgpunj	168	11	devise	devise	VB
cord-306921-3afgpunj	168	12	mechanisms	mechanism	NNS
cord-306921-3afgpunj	168	13	of	of	IN
cord-306921-3afgpunj	168	14	protecting	protect	VBG
cord-306921-3afgpunj	168	15	themselves	-PRON-	PRP
cord-306921-3afgpunj	168	16	from	from	IN
cord-306921-3afgpunj	168	17	the	the	DT
cord-306921-3afgpunj	168	18	hostile	hostile	JJ
cord-306921-3afgpunj	168	19	environments	environment	NNS
cord-306921-3afgpunj	168	20	within	within	IN
cord-306921-3afgpunj	168	21	the	the	DT
cord-306921-3afgpunj	168	22	host	host	NN
cord-306921-3afgpunj	168	23	.	.	.
cord-306921-3afgpunj	169	1	These	these	DT
cord-306921-3afgpunj	169	2	interactions	interaction	NNS
cord-306921-3afgpunj	169	3	result	result	VBP
cord-306921-3afgpunj	169	4	in	in	IN
cord-306921-3afgpunj	169	5	the	the	DT
cord-306921-3afgpunj	169	6	protection	protection	NN
cord-306921-3afgpunj	169	7	of	of	IN
cord-306921-3afgpunj	169	8	the	the	DT
cord-306921-3afgpunj	169	9	viral	viral	JJ
cord-306921-3afgpunj	169	10	RNA	RNA	NNP
cord-306921-3afgpunj	169	11	integrity	integrity	NN
cord-306921-3afgpunj	169	12	for	for	IN
cord-306921-3afgpunj	169	13	an	an	DT
cord-306921-3afgpunj	169	14	efficient	efficient	JJ
cord-306921-3afgpunj	169	15	infection	infection	NN
cord-306921-3afgpunj	169	16	and	and	CC
cord-306921-3afgpunj	169	17	eventual	eventual	JJ
cord-306921-3afgpunj	169	18	establishment	establishment	NN
cord-306921-3afgpunj	169	19	of	of	IN
cord-306921-3afgpunj	169	20	disease	disease	NN
cord-306921-3afgpunj	169	21	as	as	IN
cord-306921-3afgpunj	169	22	reviewed	review	VBN
cord-306921-3afgpunj	169	23	by	by	IN
cord-306921-3afgpunj	169	24	Barr	Barr	NNP
cord-306921-3afgpunj	169	25	and	and	CC
cord-306921-3afgpunj	169	26	Fearns	Fearns	NNPS
cord-306921-3afgpunj	169	27	[	[	-LRB-
cord-306921-3afgpunj	169	28	87	87	CD
cord-306921-3afgpunj	169	29	]	]	-RRB-
cord-306921-3afgpunj	169	30	.	.	.
cord-306921-3afgpunj	170	1	It	-PRON-	PRP
cord-306921-3afgpunj	170	2	is	be	VBZ
cord-306921-3afgpunj	170	3	a	a	DT
cord-306921-3afgpunj	170	4	common	common	JJ
cord-306921-3afgpunj	170	5	belief	belief	NN
cord-306921-3afgpunj	170	6	that	that	IN
cord-306921-3afgpunj	170	7	RNA	RNA	NNP
cord-306921-3afgpunj	170	8	viruses	virus	NNS
cord-306921-3afgpunj	170	9	can	can	MD
cord-306921-3afgpunj	170	10	remodel	remodel	VB
cord-306921-3afgpunj	170	11	their	-PRON-	PRP$
cord-306921-3afgpunj	170	12	host	host	NN
cord-306921-3afgpunj	170	13	cell	cell	NN
cord-306921-3afgpunj	170	14	intracellular	intracellular	JJ
cord-306921-3afgpunj	170	15	membranes	membrane	NNS
cord-306921-3afgpunj	170	16	to	to	TO
cord-306921-3afgpunj	170	17	form	form	VB
cord-306921-3afgpunj	170	18	double	double	JJ
cord-306921-3afgpunj	170	19	membranous	membranous	JJ
cord-306921-3afgpunj	170	20	structures	structure	NNS
cord-306921-3afgpunj	170	21	;	;	:
cord-306921-3afgpunj	170	22	replication	replication	NN
cord-306921-3afgpunj	170	23	organelles	organelle	NNS
cord-306921-3afgpunj	170	24	that	that	WDT
cord-306921-3afgpunj	170	25	acts	act	VBZ
cord-306921-3afgpunj	170	26	as	as	IN
cord-306921-3afgpunj	170	27	a	a	DT
cord-306921-3afgpunj	170	28	replication	replication	NN
cord-306921-3afgpunj	170	29	site	site	NN
cord-306921-3afgpunj	170	30	for	for	IN
cord-306921-3afgpunj	170	31	their	-PRON-	PRP$
cord-306921-3afgpunj	170	32	genome	genome	NN
cord-306921-3afgpunj	170	33	.	.	.
cord-306921-3afgpunj	171	1	However	however	RB
cord-306921-3afgpunj	171	2	,	,	,
cord-306921-3afgpunj	171	3	the	the	DT
cord-306921-3afgpunj	171	4	mechanism	mechanism	NN
cord-306921-3afgpunj	171	5	of	of	IN
cord-306921-3afgpunj	171	6	host	host	NN
cord-306921-3afgpunj	171	7	cell	cell	NN
cord-306921-3afgpunj	171	8	remodeling	remodeling	NN
cord-306921-3afgpunj	171	9	has	have	VBZ
cord-306921-3afgpunj	171	10	not	not	RB
cord-306921-3afgpunj	171	11	been	be	VBN
cord-306921-3afgpunj	171	12	fully	fully	RB
cord-306921-3afgpunj	171	13	explicated	explicate	VBN
cord-306921-3afgpunj	171	14	.	.	.
cord-306921-3afgpunj	172	1	The	the	DT
cord-306921-3afgpunj	172	2	sequential	sequential	JJ
cord-306921-3afgpunj	172	3	events	event	NNS
cord-306921-3afgpunj	172	4	leading	lead	VBG
cord-306921-3afgpunj	172	5	to	to	IN
cord-306921-3afgpunj	172	6	the	the	DT
cord-306921-3afgpunj	172	7	formation	formation	NN
cord-306921-3afgpunj	172	8	of	of	IN
cord-306921-3afgpunj	172	9	replication	replication	NN
cord-306921-3afgpunj	172	10	organelles	organelle	NNS
cord-306921-3afgpunj	172	11	are	be	VBP
cord-306921-3afgpunj	172	12	not	not	RB
cord-306921-3afgpunj	172	13	yet	yet	RB
cord-306921-3afgpunj	172	14	fully	fully	RB
cord-306921-3afgpunj	172	15	identified	identify	VBN
cord-306921-3afgpunj	172	16	.	.	.
cord-306921-3afgpunj	173	1	There	there	EX
cord-306921-3afgpunj	173	2	is	be	VBZ
cord-306921-3afgpunj	173	3	need	nee	VBN
cord-306921-3afgpunj	173	4	to	to	TO
cord-306921-3afgpunj	173	5	elucidate	elucidate	VB
cord-306921-3afgpunj	173	6	the	the	DT
cord-306921-3afgpunj	173	7	role	role	NN
cord-306921-3afgpunj	173	8	of	of	IN
cord-306921-3afgpunj	173	9	the	the	DT
cord-306921-3afgpunj	173	10	human	human	JJ
cord-306921-3afgpunj	173	11	host	host	NN
cord-306921-3afgpunj	173	12	factors	factor	NNS
cord-306921-3afgpunj	173	13	especially	especially	RB
cord-306921-3afgpunj	173	14	the	the	DT
cord-306921-3afgpunj	173	15	lipid	lipid	NN
cord-306921-3afgpunj	173	16	transfer	transfer	NN
cord-306921-3afgpunj	173	17	proteins	protein	NNS
cord-306921-3afgpunj	173	18	within	within	IN
cord-306921-3afgpunj	173	19	the	the	DT
cord-306921-3afgpunj	173	20	endoplasmic	endoplasmic	NN
cord-306921-3afgpunj	173	21	reticulum	reticulum	NN
cord-306921-3afgpunj	173	22	.	.	.
cord-306921-3afgpunj	174	1	It	-PRON-	PRP
cord-306921-3afgpunj	174	2	has	have	VBZ
cord-306921-3afgpunj	174	3	been	be	VBN
cord-306921-3afgpunj	174	4	postulated	postulate	VBN
cord-306921-3afgpunj	174	5	that	that	IN
cord-306921-3afgpunj	174	6	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	174	7	usurp	usurp	VBP
cord-306921-3afgpunj	174	8	the	the	DT
cord-306921-3afgpunj	174	9	lipid	lipid	NN
cord-306921-3afgpunj	174	10	transfer	transfer	NN
cord-306921-3afgpunj	174	11	at	at	IN
cord-306921-3afgpunj	174	12	the	the	DT
cord-306921-3afgpunj	174	13	membrane	membrane	NN
cord-306921-3afgpunj	174	14	to	to	TO
cord-306921-3afgpunj	174	15	aid	aid	VB
cord-306921-3afgpunj	174	16	in	in	IN
cord-306921-3afgpunj	174	17	the	the	DT
cord-306921-3afgpunj	174	18	formation	formation	NN
cord-306921-3afgpunj	174	19	of	of	IN
cord-306921-3afgpunj	174	20	the	the	DT
cord-306921-3afgpunj	174	21	replication	replication	NN
cord-306921-3afgpunj	174	22	organelles	organelle	NNS
cord-306921-3afgpunj	174	23	[	[	-LRB-
cord-306921-3afgpunj	174	24	88	88	CD
cord-306921-3afgpunj	174	25	]	]	-RRB-
cord-306921-3afgpunj	174	26	.	.	.
cord-306921-3afgpunj	175	1	Stoeck	Stoeck	NNP
cord-306921-3afgpunj	175	2	and	and	CC
cord-306921-3afgpunj	175	3	his	-PRON-	PRP$
cord-306921-3afgpunj	175	4	colleagues	colleague	NNS
cord-306921-3afgpunj	175	5	showed	show	VBD
cord-306921-3afgpunj	175	6	that	that	IN
cord-306921-3afgpunj	175	7	Hepatitis	Hepatitis	NNP
cord-306921-3afgpunj	175	8	C	C	NNP
cord-306921-3afgpunj	175	9	virus	virus	NN
cord-306921-3afgpunj	175	10	(	(	-LRB-
cord-306921-3afgpunj	175	11	HCV	HCV	NNP
cord-306921-3afgpunj	175	12	)	)	-RRB-
cord-306921-3afgpunj	175	13	;	;	,
cord-306921-3afgpunj	175	14	positive	positive	JJ
cord-306921-3afgpunj	175	15	stranded	strand	VBN
cord-306921-3afgpunj	175	16	RNA	RNA	NNP
cord-306921-3afgpunj	175	17	virus	virus	NN
cord-306921-3afgpunj	175	18	usurps	usurp	VBZ
cord-306921-3afgpunj	175	19	lipid	lipid	NN
cord-306921-3afgpunj	175	20	transfer	transfer	NN
cord-306921-3afgpunj	175	21	protein	protein	NN
cord-306921-3afgpunj	175	22	Neimann	Neimann	NNP
cord-306921-3afgpunj	175	23	pick	pick	VBP
cord-306921-3afgpunj	175	24	type	type	NN
cord-306921-3afgpunj	175	25	C1(NPC1	c1(npc1	NN
cord-306921-3afgpunj	175	26	)	)	-RRB-
cord-306921-3afgpunj	175	27	within	within	IN
cord-306921-3afgpunj	175	28	the	the	DT
cord-306921-3afgpunj	175	29	late	late	JJ
cord-306921-3afgpunj	175	30	endosomes	endosome	NNS
cord-306921-3afgpunj	175	31	where	where	WRB
cord-306921-3afgpunj	175	32	it	-PRON-	PRP
cord-306921-3afgpunj	175	33	leads	lead	VBZ
cord-306921-3afgpunj	175	34	in	in	IN
cord-306921-3afgpunj	175	35	localization	localization	NN
cord-306921-3afgpunj	175	36	of	of	IN
cord-306921-3afgpunj	175	37	cholesterol	cholesterol	NN
cord-306921-3afgpunj	175	38	leading	lead	VBG
cord-306921-3afgpunj	175	39	to	to	IN
cord-306921-3afgpunj	175	40	the	the	DT
cord-306921-3afgpunj	175	41	formation	formation	NN
cord-306921-3afgpunj	175	42	of	of	IN
cord-306921-3afgpunj	175	43	the	the	DT
cord-306921-3afgpunj	175	44	double	double	JJ
cord-306921-3afgpunj	175	45	membrane	membrane	NN
cord-306921-3afgpunj	175	46	structures	structure	NNS
cord-306921-3afgpunj	175	47	essential	essential	JJ
cord-306921-3afgpunj	175	48	for	for	IN
cord-306921-3afgpunj	175	49	the	the	DT
cord-306921-3afgpunj	175	50	formation	formation	NN
cord-306921-3afgpunj	175	51	of	of	IN
cord-306921-3afgpunj	175	52	the	the	DT
cord-306921-3afgpunj	175	53	replication	replication	NN
cord-306921-3afgpunj	175	54	organelle	organelle	NN
cord-306921-3afgpunj	175	55	[	[	-LRB-
cord-306921-3afgpunj	175	56	89	89	CD
cord-306921-3afgpunj	175	57	]	]	-RRB-
cord-306921-3afgpunj	175	58	.	.	.
cord-306921-3afgpunj	176	1	It	-PRON-	PRP
cord-306921-3afgpunj	176	2	will	will	MD
cord-306921-3afgpunj	176	3	be	be	VB
cord-306921-3afgpunj	176	4	important	important	JJ
cord-306921-3afgpunj	176	5	to	to	TO
cord-306921-3afgpunj	176	6	elucidate	elucidate	VB
cord-306921-3afgpunj	176	7	the	the	DT
cord-306921-3afgpunj	176	8	role	role	NN
cord-306921-3afgpunj	176	9	of	of	IN
cord-306921-3afgpunj	176	10	other	other	JJ
cord-306921-3afgpunj	176	11	known	know	VBN
cord-306921-3afgpunj	176	12	lipid	lipid	NN
cord-306921-3afgpunj	176	13	transport	transport	NN
cord-306921-3afgpunj	176	14	proteins	protein	NNS
cord-306921-3afgpunj	176	15	including	include	VBG
cord-306921-3afgpunj	176	16	steroidogenic	steroidogenic	NNP
cord-306921-3afgpunj	176	17	acute	acute	JJ
cord-306921-3afgpunj	176	18	regulatory	regulatory	JJ
cord-306921-3afgpunj	176	19	protein	protein	NN
cord-306921-3afgpunj	176	20	(	(	-LRB-
cord-306921-3afgpunj	176	21	StAR	StAR	NNP
cord-306921-3afgpunj	176	22	)	)	-RRB-
cord-306921-3afgpunj	176	23	and	and	CC
cord-306921-3afgpunj	176	24	Oxysterol	Oxysterol	NNP
cord-306921-3afgpunj	176	25	-	-	HYPH
cord-306921-3afgpunj	176	26	binding	bind	VBG
cord-306921-3afgpunj	176	27	protein	protein	NN
cord-306921-3afgpunj	176	28	-	-	HYPH
cord-306921-3afgpunj	176	29	related	relate	VBN
cord-306921-3afgpunj	176	30	protein	protein	NN
cord-306921-3afgpunj	176	31	1A	1a	NN
cord-306921-3afgpunj	176	32	and	and	CC
cord-306921-3afgpunj	176	33	B	B	NNP
cord-306921-3afgpunj	176	34	(	(	-LRB-
cord-306921-3afgpunj	176	35	OSBPL1A	OSBPL1A	NNP
cord-306921-3afgpunj	176	36	)	)	-RRB-
cord-306921-3afgpunj	176	37	in	in	IN
cord-306921-3afgpunj	176	38	the	the	DT
cord-306921-3afgpunj	176	39	formation	formation	NN
cord-306921-3afgpunj	176	40	of	of	IN
cord-306921-3afgpunj	176	41	replication	replication	NN
cord-306921-3afgpunj	176	42	organelle	organelle	NN
cord-306921-3afgpunj	176	43	during	during	IN
cord-306921-3afgpunj	176	44	NPEV	NPEV	NNP
cord-306921-3afgpunj	176	45	viral	viral	JJ
cord-306921-3afgpunj	176	46	infections	infection	NNS
cord-306921-3afgpunj	176	47	.	.	.
cord-306921-3afgpunj	177	1	Hsu	Hsu	NNP
cord-306921-3afgpunj	177	2	and	and	CC
cord-306921-3afgpunj	177	3	colleagues	colleague	NNS
cord-306921-3afgpunj	177	4	showed	show	VBD
cord-306921-3afgpunj	177	5	how	how	WRB
cord-306921-3afgpunj	177	6	viruses	virus	NNS
cord-306921-3afgpunj	177	7	usurp	usurp	VBP
cord-306921-3afgpunj	177	8	host	host	NN
cord-306921-3afgpunj	177	9	processes	process	NNS
cord-306921-3afgpunj	177	10	and	and	CC
cord-306921-3afgpunj	177	11	proteins	protein	NNS
cord-306921-3afgpunj	177	12	to	to	TO
cord-306921-3afgpunj	177	13	reorganize	reorganize	VB
cord-306921-3afgpunj	177	14	host	host	NN
cord-306921-3afgpunj	177	15	membranes	membrane	NNS
cord-306921-3afgpunj	177	16	to	to	TO
cord-306921-3afgpunj	177	17	form	form	VB
cord-306921-3afgpunj	177	18	replication	replication	NN
cord-306921-3afgpunj	177	19	organelles	organelle	NNS
cord-306921-3afgpunj	177	20	via	via	IN
cord-306921-3afgpunj	177	21	the	the	DT
cord-306921-3afgpunj	177	22	reorganization	reorganization	NN
cord-306921-3afgpunj	177	23	of	of	IN
cord-306921-3afgpunj	177	24	the	the	DT
cord-306921-3afgpunj	177	25	secretory	secretory	JJ
cord-306921-3afgpunj	177	26	pathways	pathway	NNS
cord-306921-3afgpunj	177	27	[	[	-LRB-
cord-306921-3afgpunj	177	28	90	90	CD
cord-306921-3afgpunj	177	29	]	]	-RRB-
cord-306921-3afgpunj	177	30	.	.	.
cord-306921-3afgpunj	178	1	This	this	DT
cord-306921-3afgpunj	178	2	study	study	NN
cord-306921-3afgpunj	178	3	showed	show	VBD
cord-306921-3afgpunj	178	4	how	how	WRB
cord-306921-3afgpunj	178	5	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	178	6	and	and	CC
cord-306921-3afgpunj	178	7	flaviviruses	flaviviruses	NNP
cord-306921-3afgpunj	178	8	exploit	exploit	VBP
cord-306921-3afgpunj	178	9	host	host	NN
cord-306921-3afgpunj	178	10	machinery	machinery	NN
cord-306921-3afgpunj	178	11	;	;	:
cord-306921-3afgpunj	178	12	Arf1	Arf1	NNP
cord-306921-3afgpunj	178	13	and	and	CC
cord-306921-3afgpunj	178	14	GBF1	GBF1	NNP
cord-306921-3afgpunj	178	15	resulting	result	VBG
cord-306921-3afgpunj	178	16	in	in	IN
cord-306921-3afgpunj	178	17	recruitment	recruitment	NN
cord-306921-3afgpunj	178	18	of	of	IN
cord-306921-3afgpunj	178	19	phosphatidylinositol-4phosphate(PI4P	phosphatidylinositol-4phosphate(pi4p	JJ
cord-306921-3afgpunj	178	20	)	)	-RRB-
cord-306921-3afgpunj	178	21	lipid	lipid	NN
cord-306921-3afgpunj	178	22	augmented	augment	VBN
cord-306921-3afgpunj	178	23	organelles	organelle	NNS
cord-306921-3afgpunj	178	24	vital	vital	JJ
cord-306921-3afgpunj	178	25	for	for	IN
cord-306921-3afgpunj	178	26	their	-PRON-	PRP$
cord-306921-3afgpunj	178	27	replication	replication	NN
cord-306921-3afgpunj	178	28	[	[	-LRB-
cord-306921-3afgpunj	178	29	90	90	CD
cord-306921-3afgpunj	178	30	]	]	-RRB-
cord-306921-3afgpunj	178	31	.	.	.
cord-306921-3afgpunj	179	1	Specifically	specifically	RB
cord-306921-3afgpunj	179	2	,	,	,
cord-306921-3afgpunj	179	3	this	this	DT
cord-306921-3afgpunj	179	4	study	study	NN
cord-306921-3afgpunj	179	5	showed	show	VBD
cord-306921-3afgpunj	179	6	that	that	IN
cord-306921-3afgpunj	179	7	enterovirus	enterovirus	NN
cord-306921-3afgpunj	179	8	RNA	rna	NN
cord-306921-3afgpunj	179	9	polymerase	polymerase	NN
cord-306921-3afgpunj	179	10	binds	bind	VBZ
cord-306921-3afgpunj	179	11	PI4P	PI4P	NNP
cord-306921-3afgpunj	179	12	thus	thus	RB
cord-306921-3afgpunj	179	13	illustrating	illustrate	VBG
cord-306921-3afgpunj	179	14	the	the	DT
cord-306921-3afgpunj	179	15	importance	importance	NN
cord-306921-3afgpunj	179	16	of	of	IN
cord-306921-3afgpunj	179	17	phosphoinositide	phosphoinositide	JJ
cord-306921-3afgpunj	179	18	lipids	lipid	NNS
cord-306921-3afgpunj	179	19	during	during	IN
cord-306921-3afgpunj	179	20	viral	viral	JJ
cord-306921-3afgpunj	179	21	genome	genome	NN
cord-306921-3afgpunj	179	22	replication	replication	NN
cord-306921-3afgpunj	179	23	.	.	.
cord-306921-3afgpunj	180	1	Zhang	Zhang	NNP
cord-306921-3afgpunj	180	2	and	and	CC
cord-306921-3afgpunj	180	3	colleagues	colleague	NNS
cord-306921-3afgpunj	180	4	elucidated	elucidate	VBD
cord-306921-3afgpunj	180	5	that	that	IN
cord-306921-3afgpunj	180	6	ARF1	ARF1	NNP
cord-306921-3afgpunj	180	7	and	and	CC
cord-306921-3afgpunj	180	8	GBF1	GBF1	NNP
cord-306921-3afgpunj	180	9	;	;	:
cord-306921-3afgpunj	180	10	vesicular	vesicular	JJ
cord-306921-3afgpunj	180	11	proteins	protein	NNS
cord-306921-3afgpunj	180	12	colocalizes	colocalizes	JJ
cord-306921-3afgpunj	180	13	with	with	IN
cord-306921-3afgpunj	180	14	phosphatidylinositol-4-kinase	phosphatidylinositol-4-kinase	NNP
cord-306921-3afgpunj	180	15	IIIβ(PI4PIIIβ	IIIβ(PI4PIIIβ	''
cord-306921-3afgpunj	180	16	)	)	-RRB-
cord-306921-3afgpunj	180	17	leading	lead	VBG
cord-306921-3afgpunj	180	18	to	to	IN
cord-306921-3afgpunj	180	19	accumulation	accumulation	NN
cord-306921-3afgpunj	180	20	of	of	IN
cord-306921-3afgpunj	180	21	PI4P	PI4P	NNP
cord-306921-3afgpunj	180	22	thus	thus	RB
cord-306921-3afgpunj	180	23	pointing	point	VBG
cord-306921-3afgpunj	180	24	to	to	IN
cord-306921-3afgpunj	180	25	their	-PRON-	PRP$
cord-306921-3afgpunj	180	26	essential	essential	JJ
cord-306921-3afgpunj	180	27	role	role	NN
cord-306921-3afgpunj	180	28	during	during	IN
cord-306921-3afgpunj	180	29	HCV	HCV	NNP
cord-306921-3afgpunj	180	30	virus	virus	NN
cord-306921-3afgpunj	180	31	infection	infection	NN
cord-306921-3afgpunj	180	32	[	[	-LRB-
cord-306921-3afgpunj	180	33	91	91	CD
cord-306921-3afgpunj	180	34	]	]	-RRB-
cord-306921-3afgpunj	180	35	.	.	.
cord-306921-3afgpunj	181	1	This	this	DT
cord-306921-3afgpunj	181	2	far	far	RB
cord-306921-3afgpunj	181	3	,	,	,
cord-306921-3afgpunj	181	4	it	-PRON-	PRP
cord-306921-3afgpunj	181	5	has	have	VBZ
cord-306921-3afgpunj	181	6	been	be	VBN
cord-306921-3afgpunj	181	7	shown	show	VBN
cord-306921-3afgpunj	181	8	that	that	IN
cord-306921-3afgpunj	181	9	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	181	10	recruit	recruit	VBP
cord-306921-3afgpunj	181	11	PI4PIIIβ	PI4PIIIβ	NNP
cord-306921-3afgpunj	181	12	via	via	IN
cord-306921-3afgpunj	181	13	the	the	DT
cord-306921-3afgpunj	181	14	3A	3A	NNP
cord-306921-3afgpunj	181	15	viral	viral	JJ
cord-306921-3afgpunj	181	16	protein	protein	NN
cord-306921-3afgpunj	181	17	for	for	IN
cord-306921-3afgpunj	181	18	efficient	efficient	JJ
cord-306921-3afgpunj	181	19	viral	viral	JJ
cord-306921-3afgpunj	181	20	genome	genome	NN
cord-306921-3afgpunj	181	21	replication	replication	NN
cord-306921-3afgpunj	181	22	.	.	.
cord-306921-3afgpunj	182	1	A	a	DT
cord-306921-3afgpunj	182	2	study	study	NN
cord-306921-3afgpunj	182	3	by	by	IN
cord-306921-3afgpunj	182	4	Dorobantu	Dorobantu	NNP
cord-306921-3afgpunj	182	5	and	and	CC
cord-306921-3afgpunj	182	6	colleagues	colleague	NNS
cord-306921-3afgpunj	182	7	highlighted	highlight	VBD
cord-306921-3afgpunj	182	8	that	that	IN
cord-306921-3afgpunj	182	9	the	the	DT
cord-306921-3afgpunj	182	10	recruitment	recruitment	NN
cord-306921-3afgpunj	182	11	of	of	IN
cord-306921-3afgpunj	182	12	PI4PIIIβ	PI4PIIIβ	NNP
cord-306921-3afgpunj	182	13	to	to	IN
cord-306921-3afgpunj	182	14	the	the	DT
cord-306921-3afgpunj	182	15	replication	replication	NN
cord-306921-3afgpunj	182	16	organelle	organelle	NN
cord-306921-3afgpunj	182	17	does	do	VBZ
cord-306921-3afgpunj	182	18	not	not	RB
cord-306921-3afgpunj	182	19	depend	depend	VB
cord-306921-3afgpunj	182	20	on	on	IN
cord-306921-3afgpunj	182	21	the	the	DT
cord-306921-3afgpunj	182	22	interactions	interaction	NNS
cord-306921-3afgpunj	182	23	of	of	IN
cord-306921-3afgpunj	182	24	GBF1	GBF1	NNP
cord-306921-3afgpunj	182	25	/	/	SYM
cord-306921-3afgpunj	182	26	ARFA	ARFA	NNP
cord-306921-3afgpunj	182	27	and	and	CC
cord-306921-3afgpunj	182	28	acyl	acyl	NN
cord-306921-3afgpunj	182	29	coenzyme	coenzyme	VBZ
cord-306921-3afgpunj	182	30	A	a	DT
cord-306921-3afgpunj	182	31	[	[	-LRB-
cord-306921-3afgpunj	182	32	acyl	acyl	NN
cord-306921-3afgpunj	182	33	-	-	HYPH
cord-306921-3afgpunj	182	34	CoA]-binding	coa]-binde	VBG
cord-306921-3afgpunj	182	35	protein	protein	NN
cord-306921-3afgpunj	182	36	domain	domain	NN
cord-306921-3afgpunj	182	37	3	3	CD
cord-306921-3afgpunj	182	38	(	(	-LRB-
cord-306921-3afgpunj	182	39	ACBD3	ACBD3	NNP
cord-306921-3afgpunj	182	40	)	)	-RRB-
cord-306921-3afgpunj	182	41	during	during	IN
cord-306921-3afgpunj	182	42	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	182	43	B3	B3	NNP
cord-306921-3afgpunj	182	44	replication	replication	NN
cord-306921-3afgpunj	182	45	[	[	-LRB-
cord-306921-3afgpunj	182	46	92	92	CD
cord-306921-3afgpunj	182	47	]	]	-RRB-
cord-306921-3afgpunj	182	48	.	.	.
cord-306921-3afgpunj	183	1	Thus	thus	RB
cord-306921-3afgpunj	183	2	,	,	,
cord-306921-3afgpunj	183	3	the	the	DT
cord-306921-3afgpunj	183	4	mechanisms	mechanism	NNS
cord-306921-3afgpunj	183	5	of	of	IN
cord-306921-3afgpunj	183	6	recruiting	recruit	VBG
cord-306921-3afgpunj	183	7	the	the	DT
cord-306921-3afgpunj	183	8	PI4P	PI4P	NNS
cord-306921-3afgpunj	183	9	leading	lead	VBG
cord-306921-3afgpunj	183	10	to	to	IN
cord-306921-3afgpunj	183	11	subsequent	subsequent	JJ
cord-306921-3afgpunj	183	12	formation	formation	NN
cord-306921-3afgpunj	183	13	of	of	IN
cord-306921-3afgpunj	183	14	replication	replication	NN
cord-306921-3afgpunj	183	15	complex	complex	NN
cord-306921-3afgpunj	183	16	remains	remain	VBZ
cord-306921-3afgpunj	183	17	unclear	unclear	JJ
cord-306921-3afgpunj	183	18	.	.	.
cord-306921-3afgpunj	184	1	Furthermore	furthermore	RB
cord-306921-3afgpunj	184	2	,	,	,
cord-306921-3afgpunj	184	3	studies	study	NNS
cord-306921-3afgpunj	184	4	by	by	IN
cord-306921-3afgpunj	184	5	Xiao	Xiao	NNP
cord-306921-3afgpunj	184	6	and	and	CC
cord-306921-3afgpunj	184	7	coworkers	coworker	NNS
cord-306921-3afgpunj	184	8	showed	show	VBD
cord-306921-3afgpunj	184	9	that	that	IN
cord-306921-3afgpunj	184	10	EV	EV	NNP
cord-306921-3afgpunj	184	11	-	-	HYPH
cord-306921-3afgpunj	184	12	A71	A71	NNP
cord-306921-3afgpunj	184	13	3A	3a	NN
cord-306921-3afgpunj	184	14	protein	protein	NN
cord-306921-3afgpunj	184	15	facilitates	facilitate	VBZ
cord-306921-3afgpunj	184	16	the	the	DT
cord-306921-3afgpunj	184	17	interaction	interaction	NN
cord-306921-3afgpunj	184	18	between	between	IN
cord-306921-3afgpunj	184	19	ACBD3	ACBD3	NNP
cord-306921-3afgpunj	184	20	and	and	CC
cord-306921-3afgpunj	184	21	PI4PIIIβ	PI4PIIIβ	NNP
cord-306921-3afgpunj	184	22	at	at	IN
cord-306921-3afgpunj	184	23	the	the	DT
cord-306921-3afgpunj	184	24	replication	replication	NN
cord-306921-3afgpunj	184	25	sites	site	NNS
cord-306921-3afgpunj	184	26	[	[	-LRB-
cord-306921-3afgpunj	184	27	93	93	CD
cord-306921-3afgpunj	184	28	]	]	-RRB-
cord-306921-3afgpunj	184	29	.	.	.
cord-306921-3afgpunj	185	1	Contrary	contrary	JJ
cord-306921-3afgpunj	185	2	to	to	IN
cord-306921-3afgpunj	185	3	previous	previous	JJ
cord-306921-3afgpunj	185	4	studies	study	NNS
cord-306921-3afgpunj	185	5	showing	show	VBG
cord-306921-3afgpunj	185	6	that	that	IN
cord-306921-3afgpunj	185	7	PI4PIIIβ	PI4PIIIβ	NNP
cord-306921-3afgpunj	185	8	recruitment	recruitment	NN
cord-306921-3afgpunj	185	9	is	be	VBZ
cord-306921-3afgpunj	185	10	independent	independent	JJ
cord-306921-3afgpunj	185	11	of	of	IN
cord-306921-3afgpunj	185	12	ACBD3	ACBD3	NNP
cord-306921-3afgpunj	185	13	during	during	IN
cord-306921-3afgpunj	185	14	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	185	15	infection	infection	NN
cord-306921-3afgpunj	185	16	,	,	,
cord-306921-3afgpunj	185	17	this	this	DT
cord-306921-3afgpunj	185	18	particular	particular	JJ
cord-306921-3afgpunj	185	19	study	study	NN
cord-306921-3afgpunj	185	20	points	point	VBZ
cord-306921-3afgpunj	185	21	to	to	IN
cord-306921-3afgpunj	185	22	a	a	DT
cord-306921-3afgpunj	185	23	selective	selective	JJ
cord-306921-3afgpunj	185	24	recruitment	recruitment	NN
cord-306921-3afgpunj	185	25	strategy	strategy	NN
cord-306921-3afgpunj	185	26	of	of	IN
cord-306921-3afgpunj	185	27	PI4PIIIβ	PI4PIIIβ	NNP
cord-306921-3afgpunj	185	28	facilitated	facilitate	VBN
cord-306921-3afgpunj	185	29	by	by	IN
cord-306921-3afgpunj	185	30	3A	3A	NNP
cord-306921-3afgpunj	185	31	protein	protein	NN
cord-306921-3afgpunj	185	32	to	to	IN
cord-306921-3afgpunj	185	33	the	the	DT
cord-306921-3afgpunj	185	34	replication	replication	NN
cord-306921-3afgpunj	185	35	sites	site	NNS
cord-306921-3afgpunj	185	36	during	during	IN
cord-306921-3afgpunj	185	37	EV	EV	NNP
cord-306921-3afgpunj	185	38	-	-	HYPH
cord-306921-3afgpunj	185	39	A71	A71	NNP
cord-306921-3afgpunj	185	40	infections	infection	NNS
cord-306921-3afgpunj	185	41	[	[	-LRB-
cord-306921-3afgpunj	185	42	93	93	CD
cord-306921-3afgpunj	185	43	]	]	-RRB-
cord-306921-3afgpunj	185	44	.	.	.
cord-306921-3afgpunj	186	1	A	a	DT
cord-306921-3afgpunj	186	2	study	study	NN
cord-306921-3afgpunj	186	3	by	by	IN
cord-306921-3afgpunj	186	4	Banerjees	Banerjees	NNP
cord-306921-3afgpunj	186	5	recently	recently	RB
cord-306921-3afgpunj	186	6	identified	identify	VBD
cord-306921-3afgpunj	186	7	that	that	IN
cord-306921-3afgpunj	186	8	picornaviral	picornaviral	NNP
cord-306921-3afgpunj	186	9	3CD	3CD	NNP
cord-306921-3afgpunj	186	10	protein	protein	NN
cord-306921-3afgpunj	186	11	plays	play	VBZ
cord-306921-3afgpunj	186	12	a	a	DT
cord-306921-3afgpunj	186	13	crucial	crucial	JJ
cord-306921-3afgpunj	186	14	role	role	NN
cord-306921-3afgpunj	186	15	as	as	IN
cord-306921-3afgpunj	186	16	a	a	DT
cord-306921-3afgpunj	186	17	master	master	NN
cord-306921-3afgpunj	186	18	regulator	regulator	NN
cord-306921-3afgpunj	186	19	during	during	IN
cord-306921-3afgpunj	186	20	hijacking	hijacking	NN
cord-306921-3afgpunj	186	21	of	of	IN
cord-306921-3afgpunj	186	22	the	the	DT
cord-306921-3afgpunj	186	23	host	host	NN
cord-306921-3afgpunj	186	24	cell	cell	NN
cord-306921-3afgpunj	186	25	phospholipid	phospholipid	NN
cord-306921-3afgpunj	186	26	biosynthetic	biosynthetic	JJ
cord-306921-3afgpunj	186	27	pathways	pathway	NNS
cord-306921-3afgpunj	186	28	;	;	:
cord-306921-3afgpunj	186	29	eventually	eventually	RB
cord-306921-3afgpunj	186	30	resulting	result	VBG
cord-306921-3afgpunj	186	31	in	in	IN
cord-306921-3afgpunj	186	32	proliferation	proliferation	NN
cord-306921-3afgpunj	186	33	of	of	IN
cord-306921-3afgpunj	186	34	the	the	DT
cord-306921-3afgpunj	186	35	membranes	membrane	NNS
cord-306921-3afgpunj	186	36	at	at	IN
cord-306921-3afgpunj	186	37	the	the	DT
cord-306921-3afgpunj	186	38	specific	specific	JJ
cord-306921-3afgpunj	186	39	point	point	NN
cord-306921-3afgpunj	186	40	[	[	-LRB-
cord-306921-3afgpunj	186	41	94	94	CD
cord-306921-3afgpunj	186	42	]	]	-RRB-
cord-306921-3afgpunj	186	43	.	.	.
cord-306921-3afgpunj	187	1	This	this	DT
cord-306921-3afgpunj	187	2	study	study	NN
cord-306921-3afgpunj	187	3	demonstrated	demonstrate	VBD
cord-306921-3afgpunj	187	4	that	that	IN
cord-306921-3afgpunj	187	5	3CD	3cd	CD
cord-306921-3afgpunj	187	6	viral	viral	JJ
cord-306921-3afgpunj	187	7	protein	protein	NN
cord-306921-3afgpunj	187	8	alone	alone	RB
cord-306921-3afgpunj	187	9	is	be	VBZ
cord-306921-3afgpunj	187	10	sufficient	sufficient	JJ
cord-306921-3afgpunj	187	11	to	to	TO
cord-306921-3afgpunj	187	12	induce	induce	VB
cord-306921-3afgpunj	187	13	PI4P	PI4P	NNP
cord-306921-3afgpunj	187	14	,	,	,
cord-306921-3afgpunj	187	15	phosphatidylinositol-4,5-bisphosphate	phosphatidylinositol-4,5-bisphosphate	NNP
cord-306921-3afgpunj	187	16	(	(	-LRB-
cord-306921-3afgpunj	187	17	PIP2	PIP2	NNP
cord-306921-3afgpunj	187	18	)	)	-RRB-
cord-306921-3afgpunj	187	19	and	and	CC
cord-306921-3afgpunj	187	20	phosphatidylcholine	phosphatidylcholine	NN
cord-306921-3afgpunj	187	21	(	(	-LRB-
cord-306921-3afgpunj	187	22	PC	pc	NN
cord-306921-3afgpunj	187	23	)	)	-RRB-
cord-306921-3afgpunj	187	24	synthesis	synthesis	NN
cord-306921-3afgpunj	187	25	during	during	IN
cord-306921-3afgpunj	187	26	picornaviral	picornaviral	JJ
cord-306921-3afgpunj	187	27	infections	infection	NNS
cord-306921-3afgpunj	187	28	[	[	-LRB-
cord-306921-3afgpunj	187	29	94	94	CD
cord-306921-3afgpunj	187	30	]	]	-RRB-
cord-306921-3afgpunj	187	31	.	.	.
cord-306921-3afgpunj	188	1	To	to	IN
cord-306921-3afgpunj	188	2	this	this	DT
cord-306921-3afgpunj	188	3	end	end	NN
cord-306921-3afgpunj	188	4	,	,	,
cord-306921-3afgpunj	188	5	there	there	EX
cord-306921-3afgpunj	188	6	is	be	VBZ
cord-306921-3afgpunj	188	7	need	need	NN
cord-306921-3afgpunj	188	8	to	to	TO
cord-306921-3afgpunj	188	9	illustrate	illustrate	VB
cord-306921-3afgpunj	188	10	the	the	DT
cord-306921-3afgpunj	188	11	mechanisms	mechanism	NNS
cord-306921-3afgpunj	188	12	used	use	VBN
cord-306921-3afgpunj	188	13	by	by	IN
cord-306921-3afgpunj	188	14	this	this	DT
cord-306921-3afgpunj	188	15	viral	viral	JJ
cord-306921-3afgpunj	188	16	protein	protein	NN
cord-306921-3afgpunj	188	17	to	to	TO
cord-306921-3afgpunj	188	18	recruit	recruit	VB
cord-306921-3afgpunj	188	19	an	an	DT
cord-306921-3afgpunj	188	20	array	array	NN
cord-306921-3afgpunj	188	21	of	of	IN
cord-306921-3afgpunj	188	22	these	these	DT
cord-306921-3afgpunj	188	23	cell	cell	NN
cord-306921-3afgpunj	188	24	membrane	membrane	NN
cord-306921-3afgpunj	188	25	biogenesis	biogenesis	NN
cord-306921-3afgpunj	188	26	lipids	lipid	NNS
cord-306921-3afgpunj	188	27	.	.	.
cord-306921-3afgpunj	189	1	To	to	TO
cord-306921-3afgpunj	189	2	find	find	VB
cord-306921-3afgpunj	189	3	out	out	RP
cord-306921-3afgpunj	189	4	whether	whether	IN
cord-306921-3afgpunj	189	5	the	the	DT
cord-306921-3afgpunj	189	6	formation	formation	NN
cord-306921-3afgpunj	189	7	of	of	IN
cord-306921-3afgpunj	189	8	the	the	DT
cord-306921-3afgpunj	189	9	replication	replication	NN
cord-306921-3afgpunj	189	10	organelle	organelle	NN
cord-306921-3afgpunj	189	11	is	be	VBZ
cord-306921-3afgpunj	189	12	conserved	conserve	VBN
cord-306921-3afgpunj	189	13	among	among	IN
cord-306921-3afgpunj	189	14	the	the	DT
cord-306921-3afgpunj	189	15	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	189	16	,	,	,
cord-306921-3afgpunj	189	17	Melia	Melia	NNP
cord-306921-3afgpunj	189	18	and	and	CC
cord-306921-3afgpunj	189	19	colleagues	colleague	NNS
cord-306921-3afgpunj	189	20	studied	study	VBD
cord-306921-3afgpunj	189	21	the	the	DT
cord-306921-3afgpunj	189	22	architecture	architecture	NN
cord-306921-3afgpunj	189	23	of	of	IN
cord-306921-3afgpunj	189	24	the	the	DT
cord-306921-3afgpunj	189	25	replication	replication	NN
cord-306921-3afgpunj	189	26	organelles	organelle	NNS
cord-306921-3afgpunj	189	27	formed	form	VBN
cord-306921-3afgpunj	189	28	during	during	IN
cord-306921-3afgpunj	189	29	encephalomyocarditis	encephalomyocarditis	NNP
cord-306921-3afgpunj	189	30	virus	virus	NN
cord-306921-3afgpunj	189	31	;	;	:
cord-306921-3afgpunj	189	32	a	a	DT
cord-306921-3afgpunj	189	33	picornavirus	picornavirus	NN
cord-306921-3afgpunj	189	34	in	in	IN
cord-306921-3afgpunj	189	35	the	the	DT
cord-306921-3afgpunj	189	36	genus	genus	NN
cord-306921-3afgpunj	189	37	Cardiovirus	Cardiovirus	NNP
cord-306921-3afgpunj	189	38	[	[	-LRB-
cord-306921-3afgpunj	189	39	95	95	CD
cord-306921-3afgpunj	189	40	]	]	-RRB-
cord-306921-3afgpunj	189	41	.	.	.
cord-306921-3afgpunj	190	1	This	this	DT
cord-306921-3afgpunj	190	2	study	study	NN
cord-306921-3afgpunj	190	3	postulated	postulate	VBD
cord-306921-3afgpunj	190	4	that	that	IN
cord-306921-3afgpunj	190	5	the	the	DT
cord-306921-3afgpunj	190	6	endoplasmic	endoplasmic	NN
cord-306921-3afgpunj	190	7	reticulum	reticulum	NN
cord-306921-3afgpunj	190	8	might	may	MD
cord-306921-3afgpunj	190	9	be	be	VB
cord-306921-3afgpunj	190	10	the	the	DT
cord-306921-3afgpunj	190	11	likely	likely	JJ
cord-306921-3afgpunj	190	12	donor	donor	NN
cord-306921-3afgpunj	190	13	organelle	organelle	NN
cord-306921-3afgpunj	190	14	for	for	IN
cord-306921-3afgpunj	190	15	the	the	DT
cord-306921-3afgpunj	190	16	formation	formation	NN
cord-306921-3afgpunj	190	17	of	of	IN
cord-306921-3afgpunj	190	18	the	the	DT
cord-306921-3afgpunj	190	19	replication	replication	NN
cord-306921-3afgpunj	190	20	organelle	organelle	NN
cord-306921-3afgpunj	190	21	during	during	IN
cord-306921-3afgpunj	190	22	EMCV	EMCV	NNP
cord-306921-3afgpunj	190	23	infection	infection	NN
cord-306921-3afgpunj	190	24	[	[	-LRB-
cord-306921-3afgpunj	190	25	95	95	CD
cord-306921-3afgpunj	190	26	]	]	-RRB-
cord-306921-3afgpunj	190	27	.	.	.
cord-306921-3afgpunj	191	1	The	the	DT
cord-306921-3afgpunj	191	2	common	common	JJ
cord-306921-3afgpunj	191	3	belief	belief	NN
cord-306921-3afgpunj	191	4	that	that	IN
cord-306921-3afgpunj	191	5	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	191	6	replication	replication	NN
cord-306921-3afgpunj	191	7	and	and	CC
cord-306921-3afgpunj	191	8	evasion	evasion	NN
cord-306921-3afgpunj	191	9	of	of	IN
cord-306921-3afgpunj	191	10	the	the	DT
cord-306921-3afgpunj	191	11	innate	innate	JJ
cord-306921-3afgpunj	191	12	immune	immune	JJ
cord-306921-3afgpunj	191	13	system	system	NN
cord-306921-3afgpunj	191	14	signaling	signaling	NN
cord-306921-3afgpunj	191	15	is	be	VBZ
cord-306921-3afgpunj	191	16	aided	aid	VBN
cord-306921-3afgpunj	191	17	by	by	IN
cord-306921-3afgpunj	191	18	the	the	DT
cord-306921-3afgpunj	191	19	formation	formation	NN
cord-306921-3afgpunj	191	20	of	of	IN
cord-306921-3afgpunj	191	21	the	the	DT
cord-306921-3afgpunj	191	22	membranous	membranous	JJ
cord-306921-3afgpunj	191	23	web	web	NN
cord-306921-3afgpunj	191	24	was	be	VBD
cord-306921-3afgpunj	191	25	recently	recently	RB
cord-306921-3afgpunj	191	26	challenged	challenge	VBN
cord-306921-3afgpunj	191	27	by	by	IN
cord-306921-3afgpunj	191	28	Melia	Melia	NNP
cord-306921-3afgpunj	191	29	and	and	CC
cord-306921-3afgpunj	191	30	colleagues	colleague	NNS
cord-306921-3afgpunj	191	31	[	[	-LRB-
cord-306921-3afgpunj	191	32	96	96	CD
cord-306921-3afgpunj	191	33	]	]	-RRB-
cord-306921-3afgpunj	191	34	.	.	.
cord-306921-3afgpunj	192	1	Using	use	VBG
cord-306921-3afgpunj	192	2	a	a	DT
cord-306921-3afgpunj	192	3	known	know	VBN
cord-306921-3afgpunj	192	4	PI4PIIIβ	PI4PIIIβ	NNP
cord-306921-3afgpunj	192	5	inhibitor	inhibitor	NN
cord-306921-3afgpunj	192	6	;	;	:
cord-306921-3afgpunj	192	7	BF738735	bf738735	NN
cord-306921-3afgpunj	192	8	(	(	-LRB-
cord-306921-3afgpunj	192	9	identified	identify	VBN
cord-306921-3afgpunj	192	10	in	in	IN
cord-306921-3afgpunj	192	11	an	an	DT
cord-306921-3afgpunj	192	12	earlier	early	JJR
cord-306921-3afgpunj	192	13	screen	screen	NN
cord-306921-3afgpunj	192	14	by	by	IN
cord-306921-3afgpunj	192	15	van	van	NNP
cord-306921-3afgpunj	192	16	der	der	NNP
cord-306921-3afgpunj	192	17	Schaar	Schaar	NNP
cord-306921-3afgpunj	192	18	and	and	CC
cord-306921-3afgpunj	192	19	colleagues	colleague	NNS
cord-306921-3afgpunj	192	20	[	[	-LRB-
cord-306921-3afgpunj	192	21	97	97	CD
cord-306921-3afgpunj	192	22	]	]	-RRB-
cord-306921-3afgpunj	192	23	)	)	-RRB-
cord-306921-3afgpunj	192	24	,	,	,
cord-306921-3afgpunj	192	25	this	this	DT
cord-306921-3afgpunj	192	26	study	study	NN
cord-306921-3afgpunj	192	27	showed	show	VBD
cord-306921-3afgpunj	192	28	that	that	IN
cord-306921-3afgpunj	192	29	a	a	DT
cord-306921-3afgpunj	192	30	mutant	mutant	JJ
cord-306921-3afgpunj	192	31	coxsackievirus	coxsackievirus	NN
cord-306921-3afgpunj	192	32	(	(	-LRB-
cord-306921-3afgpunj	192	33	CV	CV	NNP
cord-306921-3afgpunj	192	34	-	-	HYPH
cord-306921-3afgpunj	192	35	B3	B3	NNP
cord-306921-3afgpunj	192	36	3A	3A	NNP
cord-306921-3afgpunj	192	37	-	-	:
cord-306921-3afgpunj	192	38	H57Y	H57Y	NNP
cord-306921-3afgpunj	192	39	)	)	-RRB-
cord-306921-3afgpunj	192	40	was	be	VBD
cord-306921-3afgpunj	192	41	able	able	JJ
cord-306921-3afgpunj	192	42	to	to	TO
cord-306921-3afgpunj	192	43	replicate	replicate	VB
cord-306921-3afgpunj	192	44	within	within	IN
cord-306921-3afgpunj	192	45	the	the	DT
cord-306921-3afgpunj	192	46	Golgi	Golgi	NNP
cord-306921-3afgpunj	192	47	apparatus	apparatus	NN
cord-306921-3afgpunj	192	48	in	in	IN
cord-306921-3afgpunj	192	49	the	the	DT
cord-306921-3afgpunj	192	50	absence	absence	NN
cord-306921-3afgpunj	192	51	of	of	IN
cord-306921-3afgpunj	192	52	replication	replication	NN
cord-306921-3afgpunj	192	53	organelles	organelle	NNS
cord-306921-3afgpunj	192	54	[	[	-LRB-
cord-306921-3afgpunj	192	55	97	97	CD
cord-306921-3afgpunj	192	56	]	]	-RRB-
cord-306921-3afgpunj	192	57	.	.	.
cord-306921-3afgpunj	193	1	To	to	IN
cord-306921-3afgpunj	193	2	this	this	DT
cord-306921-3afgpunj	193	3	end	end	NN
cord-306921-3afgpunj	193	4	,	,	,
cord-306921-3afgpunj	193	5	the	the	DT
cord-306921-3afgpunj	193	6	clear	clear	JJ
cord-306921-3afgpunj	193	7	steps	step	NNS
cord-306921-3afgpunj	193	8	involved	involve	VBN
cord-306921-3afgpunj	193	9	in	in	IN
cord-306921-3afgpunj	193	10	the	the	DT
cord-306921-3afgpunj	193	11	formation	formation	NN
cord-306921-3afgpunj	193	12	of	of	IN
cord-306921-3afgpunj	193	13	the	the	DT
cord-306921-3afgpunj	193	14	double	double	JJ
cord-306921-3afgpunj	193	15	membranous	membranous	JJ
cord-306921-3afgpunj	193	16	structures	structure	NNS
cord-306921-3afgpunj	193	17	required	require	VBN
cord-306921-3afgpunj	193	18	for	for	IN
cord-306921-3afgpunj	193	19	the	the	DT
cord-306921-3afgpunj	193	20	formation	formation	NN
cord-306921-3afgpunj	193	21	of	of	IN
cord-306921-3afgpunj	193	22	the	the	DT
cord-306921-3afgpunj	193	23	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	193	24	replication	replication	NN
cord-306921-3afgpunj	193	25	organelles	organelle	NNS
cord-306921-3afgpunj	193	26	remain	remain	VBP
cord-306921-3afgpunj	193	27	unresolved	unresolved	JJ
cord-306921-3afgpunj	193	28	.	.	.
cord-306921-3afgpunj	194	1	There	there	EX
cord-306921-3afgpunj	194	2	is	be	VBZ
cord-306921-3afgpunj	194	3	need	need	NN
cord-306921-3afgpunj	194	4	to	to	TO
cord-306921-3afgpunj	194	5	dissect	dissect	VB
cord-306921-3afgpunj	194	6	the	the	DT
cord-306921-3afgpunj	194	7	exact	exact	JJ
cord-306921-3afgpunj	194	8	mechanisms	mechanism	NNS
cord-306921-3afgpunj	194	9	involved	involve	VBN
cord-306921-3afgpunj	194	10	in	in	IN
cord-306921-3afgpunj	194	11	the	the	DT
cord-306921-3afgpunj	194	12	formation	formation	NN
cord-306921-3afgpunj	194	13	of	of	IN
cord-306921-3afgpunj	194	14	replication	replication	NN
cord-306921-3afgpunj	194	15	complex	complex	NN
cord-306921-3afgpunj	194	16	;	;	:
cord-306921-3afgpunj	194	17	a	a	DT
cord-306921-3afgpunj	194	18	mechanism	mechanism	NN
cord-306921-3afgpunj	194	19	without	without	IN
cord-306921-3afgpunj	194	20	which	which	WDT
cord-306921-3afgpunj	194	21	the	the	DT
cord-306921-3afgpunj	194	22	replication	replication	NN
cord-306921-3afgpunj	194	23	of	of	IN
cord-306921-3afgpunj	194	24	the	the	DT
cord-306921-3afgpunj	194	25	viral	viral	JJ
cord-306921-3afgpunj	194	26	genomes	genome	NNS
cord-306921-3afgpunj	194	27	becomes	become	VBZ
cord-306921-3afgpunj	194	28	compromised	compromised	JJ
cord-306921-3afgpunj	194	29	.	.	.
cord-306921-3afgpunj	195	1	This	this	DT
cord-306921-3afgpunj	195	2	might	may	MD
cord-306921-3afgpunj	195	3	be	be	VB
cord-306921-3afgpunj	195	4	an	an	DT
cord-306921-3afgpunj	195	5	opening	opening	NN
cord-306921-3afgpunj	195	6	towards	towards	IN
cord-306921-3afgpunj	195	7	the	the	DT
cord-306921-3afgpunj	195	8	development	development	NN
cord-306921-3afgpunj	195	9	and	and	CC
cord-306921-3afgpunj	195	10	or	or	CC
cord-306921-3afgpunj	195	11	design	design	NN
cord-306921-3afgpunj	195	12	of	of	IN
cord-306921-3afgpunj	195	13	antivirals	antiviral	NNS
cord-306921-3afgpunj	195	14	targeting	target	VBG
cord-306921-3afgpunj	195	15	this	this	DT
cord-306921-3afgpunj	195	16	exact	exact	JJ
cord-306921-3afgpunj	195	17	mechanism	mechanism	NN
cord-306921-3afgpunj	195	18	.	.	.
cord-306921-3afgpunj	196	1	For	for	IN
cord-306921-3afgpunj	196	2	example	example	NN
cord-306921-3afgpunj	196	3	,	,	,
cord-306921-3afgpunj	196	4	the	the	DT
cord-306921-3afgpunj	196	5	mechanisms	mechanism	NNS
cord-306921-3afgpunj	196	6	of	of	IN
cord-306921-3afgpunj	196	7	the	the	DT
cord-306921-3afgpunj	196	8	cell	cell	NN
cord-306921-3afgpunj	196	9	remodeling	remodeling	NN
cord-306921-3afgpunj	196	10	during	during	IN
cord-306921-3afgpunj	196	11	RNA	RNA	NNP
cord-306921-3afgpunj	196	12	virus	virus	NN
cord-306921-3afgpunj	196	13	infection	infection	NN
cord-306921-3afgpunj	196	14	has	have	VBZ
cord-306921-3afgpunj	196	15	been	be	VBN
cord-306921-3afgpunj	196	16	mined	mine	VBN
cord-306921-3afgpunj	196	17	by	by	IN
cord-306921-3afgpunj	196	18	a	a	DT
cord-306921-3afgpunj	196	19	recent	recent	JJ
cord-306921-3afgpunj	196	20	study	study	NN
cord-306921-3afgpunj	196	21	by	by	IN
cord-306921-3afgpunj	196	22	Nguyen	Nguyen	NNP
cord-306921-3afgpunj	196	23	and	and	CC
cord-306921-3afgpunj	196	24	coworkers	coworker	NNS
cord-306921-3afgpunj	196	25	[	[	-LRB-
cord-306921-3afgpunj	196	26	98	98	CD
cord-306921-3afgpunj	196	27	]	]	-RRB-
cord-306921-3afgpunj	196	28	.	.	.
cord-306921-3afgpunj	197	1	This	this	DT
cord-306921-3afgpunj	197	2	study	study	NN
cord-306921-3afgpunj	197	3	identified	identify	VBD
cord-306921-3afgpunj	197	4	fatty	fatty	JJ
cord-306921-3afgpunj	197	5	acid	acid	NN
cord-306921-3afgpunj	197	6	synthase	synthase	NN
cord-306921-3afgpunj	197	7	and	and	CC
cord-306921-3afgpunj	197	8	ceramidase	ceramidase	NN
cord-306921-3afgpunj	197	9	as	as	IN
cord-306921-3afgpunj	197	10	potential	potential	JJ
cord-306921-3afgpunj	197	11	inhibitory	inhibitory	JJ
cord-306921-3afgpunj	197	12	target	target	NN
cord-306921-3afgpunj	197	13	against	against	IN
cord-306921-3afgpunj	197	14	rhinoviruses	rhinovirus	NNS
cord-306921-3afgpunj	197	15	[	[	-LRB-
cord-306921-3afgpunj	197	16	98	98	CD
cord-306921-3afgpunj	197	17	]	]	-RRB-
cord-306921-3afgpunj	197	18	,	,	,
cord-306921-3afgpunj	197	19	highlighting	highlight	VBG
cord-306921-3afgpunj	197	20	the	the	DT
cord-306921-3afgpunj	197	21	possibility	possibility	NN
cord-306921-3afgpunj	197	22	of	of	IN
cord-306921-3afgpunj	197	23	targeting	target	VBG
cord-306921-3afgpunj	197	24	lipid	lipid	NN
cord-306921-3afgpunj	197	25	transfer	transfer	NN
cord-306921-3afgpunj	197	26	during	during	IN
cord-306921-3afgpunj	197	27	the	the	DT
cord-306921-3afgpunj	197	28	replication	replication	NN
cord-306921-3afgpunj	197	29	organelle	organelle	NN
cord-306921-3afgpunj	197	30	formation	formation	NN
cord-306921-3afgpunj	197	31	for	for	IN
cord-306921-3afgpunj	197	32	possible	possible	JJ
cord-306921-3afgpunj	197	33	therapeutics	therapeutic	NNS
cord-306921-3afgpunj	197	34	.	.	.
cord-306921-3afgpunj	198	1	Translation	translation	NN
cord-306921-3afgpunj	198	2	of	of	IN
cord-306921-3afgpunj	198	3	viral	viral	JJ
cord-306921-3afgpunj	198	4	proteins	protein	NNS
cord-306921-3afgpunj	198	5	upon	upon	IN
cord-306921-3afgpunj	198	6	release	release	NN
cord-306921-3afgpunj	198	7	into	into	IN
cord-306921-3afgpunj	198	8	the	the	DT
cord-306921-3afgpunj	198	9	cytoplasm	cytoplasm	NN
cord-306921-3afgpunj	198	10	is	be	VBZ
cord-306921-3afgpunj	198	11	cap	cap	NN
cord-306921-3afgpunj	198	12	-	-	HYPH
cord-306921-3afgpunj	198	13	independent	independent	JJ
cord-306921-3afgpunj	198	14	thus	thus	RB
cord-306921-3afgpunj	198	15	human	human	JJ
cord-306921-3afgpunj	198	16	host	host	NN
cord-306921-3afgpunj	198	17	proteins	protein	NNS
cord-306921-3afgpunj	198	18	binds	bind	VBZ
cord-306921-3afgpunj	198	19	to	to	IN
cord-306921-3afgpunj	198	20	the	the	DT
cord-306921-3afgpunj	198	21	viral	viral	JJ
cord-306921-3afgpunj	198	22	type	type	NN
cord-306921-3afgpunj	198	23	1	1	CD
cord-306921-3afgpunj	198	24	internal	internal	JJ
cord-306921-3afgpunj	198	25	ribosome	ribosome	NN
cord-306921-3afgpunj	198	26	entry	entry	NN
cord-306921-3afgpunj	198	27	site	site	NN
cord-306921-3afgpunj	198	28	(	(	-LRB-
cord-306921-3afgpunj	198	29	IRES	IRES	NNP
cord-306921-3afgpunj	198	30	)	)	-RRB-
cord-306921-3afgpunj	198	31	for	for	IN
cord-306921-3afgpunj	198	32	efficient	efficient	JJ
cord-306921-3afgpunj	198	33	replication	replication	NN
cord-306921-3afgpunj	198	34	.	.	.
cord-306921-3afgpunj	199	1	Some	some	DT
cord-306921-3afgpunj	199	2	nuclear	nuclear	JJ
cord-306921-3afgpunj	199	3	factors	factor	NNS
cord-306921-3afgpunj	199	4	relocate	relocate	VBP
cord-306921-3afgpunj	199	5	to	to	IN
cord-306921-3afgpunj	199	6	the	the	DT
cord-306921-3afgpunj	199	7	cytoplasm	cytoplasm	NN
cord-306921-3afgpunj	199	8	during	during	IN
cord-306921-3afgpunj	199	9	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	199	10	infections	infection	NNS
cord-306921-3afgpunj	199	11	where	where	WRB
cord-306921-3afgpunj	199	12	they	-PRON-	PRP
cord-306921-3afgpunj	199	13	bind	bind	VBP
cord-306921-3afgpunj	199	14	to	to	IN
cord-306921-3afgpunj	199	15	the	the	DT
cord-306921-3afgpunj	199	16	internal	internal	JJ
cord-306921-3afgpunj	199	17	ribosome	ribosome	NN
cord-306921-3afgpunj	199	18	entry	entry	NN
cord-306921-3afgpunj	199	19	sites	site	NNS
cord-306921-3afgpunj	199	20	(	(	-LRB-
cord-306921-3afgpunj	199	21	IRES	IRES	NNP
cord-306921-3afgpunj	199	22	)	)	-RRB-
cord-306921-3afgpunj	199	23	;	;	:
cord-306921-3afgpunj	199	24	acting	act	VBG
cord-306921-3afgpunj	199	25	as	as	IN
cord-306921-3afgpunj	199	26	internal	internal	JJ
cord-306921-3afgpunj	199	27	ribosome	ribosome	NN
cord-306921-3afgpunj	199	28	entry	entry	NN
cord-306921-3afgpunj	199	29	sites	site	NNS
cord-306921-3afgpunj	199	30	transacting	transact	VBG
cord-306921-3afgpunj	199	31	factors	factor	NNS
cord-306921-3afgpunj	199	32	(	(	-LRB-
cord-306921-3afgpunj	199	33	ITAFs	itaf	NNS
cord-306921-3afgpunj	199	34	)	)	-RRB-
cord-306921-3afgpunj	199	35	thereby	thereby	RB
cord-306921-3afgpunj	199	36	recruiting	recruit	VBG
cord-306921-3afgpunj	199	37	ribosomes	ribosome	NNS
cord-306921-3afgpunj	199	38	to	to	IN
cord-306921-3afgpunj	199	39	the	the	DT
cord-306921-3afgpunj	199	40	site	site	NN
cord-306921-3afgpunj	199	41	for	for	IN
cord-306921-3afgpunj	199	42	protein	protein	NN
cord-306921-3afgpunj	199	43	translation	translation	NN
cord-306921-3afgpunj	199	44	.	.	.
cord-306921-3afgpunj	200	1	RNA	RNA	NNP
cord-306921-3afgpunj	200	2	binding	bind	VBG
cord-306921-3afgpunj	200	3	protein	protein	NN
cord-306921-3afgpunj	200	4	;	;	:
cord-306921-3afgpunj	200	5	heterogenous	heterogenous	JJ
cord-306921-3afgpunj	200	6	nuclear	nuclear	JJ
cord-306921-3afgpunj	200	7	ribonucleoprotein	ribonucleoprotein	NN
cord-306921-3afgpunj	200	8	(	(	-LRB-
cord-306921-3afgpunj	200	9	hnRNP)A1	hnRNP)A1	NNP
cord-306921-3afgpunj	200	10	is	be	VBZ
cord-306921-3afgpunj	200	11	known	know	VBN
cord-306921-3afgpunj	200	12	to	to	TO
cord-306921-3afgpunj	200	13	shuttle	shuttle	NN
cord-306921-3afgpunj	200	14	from	from	IN
cord-306921-3afgpunj	200	15	nucleus	nucleus	NN
cord-306921-3afgpunj	200	16	to	to	TO
cord-306921-3afgpunj	200	17	cytoplasm	cytoplasm	VB
cord-306921-3afgpunj	200	18	during	during	IN
cord-306921-3afgpunj	200	19	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	200	20	infections	infection	NNS
cord-306921-3afgpunj	200	21	[	[	-LRB-
cord-306921-3afgpunj	200	22	99	99	CD
cord-306921-3afgpunj	200	23	,	,	,
cord-306921-3afgpunj	200	24	100	100	CD
cord-306921-3afgpunj	200	25	]	]	-RRB-
cord-306921-3afgpunj	200	26	.	.	.
cord-306921-3afgpunj	201	1	Lin	Lin	NNP
cord-306921-3afgpunj	201	2	and	and	CC
cord-306921-3afgpunj	201	3	colleagues	colleague	NNS
cord-306921-3afgpunj	201	4	demonstrated	demonstrate	VBD
cord-306921-3afgpunj	201	5	that	that	IN
cord-306921-3afgpunj	201	6	this	this	DT
cord-306921-3afgpunj	201	7	RNA	RNA	NNP
cord-306921-3afgpunj	201	8	binding	bind	VBG
cord-306921-3afgpunj	201	9	protein(RBP	protein(rbp	NN
cord-306921-3afgpunj	201	10	)	)	-RRB-
cord-306921-3afgpunj	201	11	is	be	VBZ
cord-306921-3afgpunj	201	12	an	an	DT
cord-306921-3afgpunj	201	13	ITAF	ITAF	NNP
cord-306921-3afgpunj	201	14	and	and	CC
cord-306921-3afgpunj	201	15	binds	bind	VBZ
cord-306921-3afgpunj	201	16	to	to	IN
cord-306921-3afgpunj	201	17	5'UTR	5'utr	CD
cord-306921-3afgpunj	201	18	of	of	IN
cord-306921-3afgpunj	201	19	EV	EV	NNP
cord-306921-3afgpunj	201	20	-	-	HYPH
cord-306921-3afgpunj	201	21	A71	A71	NNP
cord-306921-3afgpunj	201	22	and	and	CC
cord-306921-3afgpunj	201	23	Sindbis	Sindbis	NNP
cord-306921-3afgpunj	201	24	virus	virus	NN
cord-306921-3afgpunj	201	25	during	during	IN
cord-306921-3afgpunj	201	26	viral	viral	JJ
cord-306921-3afgpunj	201	27	infection	infection	NN
cord-306921-3afgpunj	201	28	thus	thus	RB
cord-306921-3afgpunj	201	29	enhancing	enhance	VBG
cord-306921-3afgpunj	201	30	viral	viral	JJ
cord-306921-3afgpunj	201	31	protein	protein	NN
cord-306921-3afgpunj	201	32	translation	translation	NN
cord-306921-3afgpunj	201	33	[	[	-LRB-
cord-306921-3afgpunj	201	34	101	101	CD
cord-306921-3afgpunj	201	35	]	]	-RRB-
cord-306921-3afgpunj	201	36	.	.	.
cord-306921-3afgpunj	202	1	Tolbert	Tolbert	NNP
cord-306921-3afgpunj	202	2	and	and	CC
cord-306921-3afgpunj	202	3	coworkers	coworker	NNS
cord-306921-3afgpunj	202	4	demonstrated	demonstrate	VBD
cord-306921-3afgpunj	202	5	that	that	IN
cord-306921-3afgpunj	202	6	hnRNP	hnrnp	DT
cord-306921-3afgpunj	202	7	A1	a1	NN
cord-306921-3afgpunj	202	8	binds	bind	VBZ
cord-306921-3afgpunj	202	9	specifically	specifically	RB
cord-306921-3afgpunj	202	10	to	to	IN
cord-306921-3afgpunj	202	11	the	the	DT
cord-306921-3afgpunj	202	12	stem	stem	NN
cord-306921-3afgpunj	202	13	loop	loop	NN
cord-306921-3afgpunj	202	14	II	II	NNP
cord-306921-3afgpunj	202	15	of	of	IN
cord-306921-3afgpunj	202	16	the	the	DT
cord-306921-3afgpunj	202	17	EV	EV	NNP
cord-306921-3afgpunj	202	18	-	-	HYPH
cord-306921-3afgpunj	202	19	A71	A71	NNP
cord-306921-3afgpunj	202	20	IRES	IRES	NNP
cord-306921-3afgpunj	202	21	[	[	-LRB-
cord-306921-3afgpunj	202	22	102	102	CD
cord-306921-3afgpunj	202	23	]	]	-RRB-
cord-306921-3afgpunj	202	24	.	.	.
cord-306921-3afgpunj	203	1	A	a	DT
cord-306921-3afgpunj	203	2	follow	follow	VB
cord-306921-3afgpunj	203	3	-	-	HYPH
cord-306921-3afgpunj	203	4	up	up	NN
cord-306921-3afgpunj	203	5	study	study	NN
cord-306921-3afgpunj	203	6	by	by	IN
cord-306921-3afgpunj	203	7	the	the	DT
cord-306921-3afgpunj	203	8	same	same	JJ
cord-306921-3afgpunj	203	9	group	group	NN
cord-306921-3afgpunj	203	10	demonstrated	demonstrate	VBD
cord-306921-3afgpunj	203	11	that	that	IN
cord-306921-3afgpunj	203	12	hnRNP	hnrnp	DT
cord-306921-3afgpunj	203	13	A1	a1	NN
cord-306921-3afgpunj	203	14	induces	induce	VBZ
cord-306921-3afgpunj	203	15	conformational	conformational	JJ
cord-306921-3afgpunj	203	16	changes	change	NNS
cord-306921-3afgpunj	203	17	upon	upon	IN
cord-306921-3afgpunj	203	18	binding	bind	VBG
cord-306921-3afgpunj	203	19	to	to	IN
cord-306921-3afgpunj	203	20	the	the	DT
cord-306921-3afgpunj	203	21	stem	stem	NN
cord-306921-3afgpunj	203	22	loop	loop	NN
cord-306921-3afgpunj	203	23	II	II	NNP
cord-306921-3afgpunj	203	24	of	of	IN
cord-306921-3afgpunj	203	25	the	the	DT
cord-306921-3afgpunj	203	26	EV	EV	NNP
cord-306921-3afgpunj	203	27	-	-	HYPH
cord-306921-3afgpunj	203	28	A71	A71	NNP
cord-306921-3afgpunj	203	29	IRES	IRES	NNP
cord-306921-3afgpunj	203	30	leading	lead	VBG
cord-306921-3afgpunj	203	31	to	to	IN
cord-306921-3afgpunj	203	32	the	the	DT
cord-306921-3afgpunj	203	33	enhanced	enhance	VBN
cord-306921-3afgpunj	203	34	viral	viral	JJ
cord-306921-3afgpunj	203	35	protein	protein	NN
cord-306921-3afgpunj	203	36	translation	translation	NN
cord-306921-3afgpunj	203	37	[	[	-LRB-
cord-306921-3afgpunj	203	38	103	103	CD
cord-306921-3afgpunj	203	39	]	]	-RRB-
cord-306921-3afgpunj	203	40	.	.	.
cord-306921-3afgpunj	204	1	HnRNP	HnRNP	NNP
cord-306921-3afgpunj	204	2	A1	A1	NNP
cord-306921-3afgpunj	204	3	has	have	VBZ
cord-306921-3afgpunj	204	4	also	also	RB
cord-306921-3afgpunj	204	5	been	be	VBN
cord-306921-3afgpunj	204	6	linked	link	VBN
cord-306921-3afgpunj	204	7	to	to	IN
cord-306921-3afgpunj	204	8	regulation	regulation	NN
cord-306921-3afgpunj	204	9	of	of	IN
cord-306921-3afgpunj	204	10	replication	replication	NN
cord-306921-3afgpunj	204	11	in	in	IN
cord-306921-3afgpunj	204	12	other	other	JJ
cord-306921-3afgpunj	204	13	viruses	virus	NNS
cord-306921-3afgpunj	204	14	such	such	JJ
cord-306921-3afgpunj	204	15	as	as	IN
cord-306921-3afgpunj	204	16	hepatitis	hepatitis	NN
cord-306921-3afgpunj	204	17	C	C	NNP
cord-306921-3afgpunj	204	18	virus	virus	NN
cord-306921-3afgpunj	204	19	[	[	-LRB-
cord-306921-3afgpunj	204	20	104	104	CD
cord-306921-3afgpunj	204	21	]	]	-RRB-
cord-306921-3afgpunj	204	22	,	,	,
cord-306921-3afgpunj	204	23	human	human	JJ
cord-306921-3afgpunj	204	24	cytomegalovirus	cytomegalovirus	NN
cord-306921-3afgpunj	204	25	where	where	WRB
cord-306921-3afgpunj	204	26	it	-PRON-	PRP
cord-306921-3afgpunj	204	27	interacts	interact	VBZ
cord-306921-3afgpunj	204	28	with	with	IN
cord-306921-3afgpunj	204	29	immediate	immediate	JJ
cord-306921-3afgpunj	204	30	early	early	JJ
cord-306921-3afgpunj	204	31	gene	gene	NN
cord-306921-3afgpunj	204	32	2	2	CD
cord-306921-3afgpunj	204	33	protein	protein	NN
cord-306921-3afgpunj	204	34	[	[	-LRB-
cord-306921-3afgpunj	204	35	105	105	CD
cord-306921-3afgpunj	204	36	]	]	-RRB-
cord-306921-3afgpunj	204	37	,	,	,
cord-306921-3afgpunj	204	38	dengue	dengue	NN
cord-306921-3afgpunj	204	39	virus	virus	NN
cord-306921-3afgpunj	204	40	[	[	-LRB-
cord-306921-3afgpunj	204	41	106	106	CD
cord-306921-3afgpunj	204	42	]	]	-RRB-
cord-306921-3afgpunj	204	43	and	and	CC
cord-306921-3afgpunj	204	44	human	human	JJ
cord-306921-3afgpunj	204	45	papillomavirus	papillomavirus	NN
cord-306921-3afgpunj	204	46	type16	type16	NN
cord-306921-3afgpunj	204	47	L1	L1	NNP
cord-306921-3afgpunj	204	48	[	[	-LRB-
cord-306921-3afgpunj	204	49	107	107	CD
cord-306921-3afgpunj	204	50	]	]	-RRB-
cord-306921-3afgpunj	204	51	among	among	IN
cord-306921-3afgpunj	204	52	other	other	JJ
cord-306921-3afgpunj	204	53	viruses	virus	NNS
cord-306921-3afgpunj	204	54	.	.	.
cord-306921-3afgpunj	205	1	Far	far	RB
cord-306921-3afgpunj	205	2	upstream	upstream	JJ
cord-306921-3afgpunj	205	3	element	element	NN
cord-306921-3afgpunj	205	4	binding	bind	VBG
cord-306921-3afgpunj	205	5	protein	protein	NN
cord-306921-3afgpunj	205	6	2	2	CD
cord-306921-3afgpunj	205	7	(	(	-LRB-
cord-306921-3afgpunj	205	8	FBP2	FBP2	NNP
cord-306921-3afgpunj	205	9	)	)	-RRB-
cord-306921-3afgpunj	205	10	was	be	VBD
cord-306921-3afgpunj	205	11	described	describe	VBN
cord-306921-3afgpunj	205	12	by	by	IN
cord-306921-3afgpunj	205	13	Lin	Lin	NNP
cord-306921-3afgpunj	205	14	and	and	CC
cord-306921-3afgpunj	205	15	colleagues	colleague	NNS
cord-306921-3afgpunj	205	16	to	to	TO
cord-306921-3afgpunj	205	17	be	be	VB
cord-306921-3afgpunj	205	18	an	an	DT
cord-306921-3afgpunj	205	19	ITAF	ITAF	NNP
cord-306921-3afgpunj	205	20	and	and	CC
cord-306921-3afgpunj	205	21	a	a	DT
cord-306921-3afgpunj	205	22	negative	negative	JJ
cord-306921-3afgpunj	205	23	regulator	regulator	NN
cord-306921-3afgpunj	205	24	of	of	IN
cord-306921-3afgpunj	205	25	EV	EV	NNP
cord-306921-3afgpunj	205	26	-	-	HYPH
cord-306921-3afgpunj	205	27	A71	A71	NNP
cord-306921-3afgpunj	205	28	IRES	IRES	NNP
cord-306921-3afgpunj	205	29	dependent	dependent	JJ
cord-306921-3afgpunj	205	30	replication	replication	NN
cord-306921-3afgpunj	205	31	[	[	-LRB-
cord-306921-3afgpunj	205	32	108	108	CD
cord-306921-3afgpunj	205	33	]	]	-RRB-
cord-306921-3afgpunj	205	34	.	.	.
cord-306921-3afgpunj	206	1	A	a	DT
cord-306921-3afgpunj	206	2	follow	follow	VB
cord-306921-3afgpunj	206	3	-	-	HYPH
cord-306921-3afgpunj	206	4	up	up	NN
cord-306921-3afgpunj	206	5	study	study	NN
cord-306921-3afgpunj	206	6	from	from	IN
cord-306921-3afgpunj	206	7	the	the	DT
cord-306921-3afgpunj	206	8	same	same	JJ
cord-306921-3afgpunj	206	9	group	group	NN
cord-306921-3afgpunj	206	10	showed	show	VBD
cord-306921-3afgpunj	206	11	that	that	IN
cord-306921-3afgpunj	206	12	EV	EV	NNP
cord-306921-3afgpunj	206	13	-	-	HYPH
cord-306921-3afgpunj	206	14	A71	A71	NNP
cord-306921-3afgpunj	206	15	induces	induce	VBZ
cord-306921-3afgpunj	206	16	proteasome	proteasome	VBN
cord-306921-3afgpunj	206	17	,	,	,
cord-306921-3afgpunj	206	18	autophagy	autophagy	NN
cord-306921-3afgpunj	206	19	and	and	CC
cord-306921-3afgpunj	206	20	caspase	caspase	NN
cord-306921-3afgpunj	206	21	activity	activity	NN
cord-306921-3afgpunj	206	22	mediated	mediate	VBN
cord-306921-3afgpunj	206	23	cleavage	cleavage	NN
cord-306921-3afgpunj	206	24	of	of	IN
cord-306921-3afgpunj	206	25	FBP2	FBP2	NNP
cord-306921-3afgpunj	206	26	into	into	IN
cord-306921-3afgpunj	206	27	a	a	DT
cord-306921-3afgpunj	206	28	positive	positive	JJ
cord-306921-3afgpunj	206	29	regulator	regulator	NN
cord-306921-3afgpunj	206	30	of	of	IN
cord-306921-3afgpunj	206	31	viral	viral	JJ
cord-306921-3afgpunj	206	32	protein	protein	NN
cord-306921-3afgpunj	206	33	synthesis	synthesis	NN
cord-306921-3afgpunj	206	34	[	[	-LRB-
cord-306921-3afgpunj	206	35	109	109	CD
cord-306921-3afgpunj	206	36	]	]	-RRB-
cord-306921-3afgpunj	206	37	.	.	.
cord-306921-3afgpunj	207	1	FBP1	FBP1	NNP
cord-306921-3afgpunj	207	2	;	;	:
cord-306921-3afgpunj	207	3	another	another	DT
cord-306921-3afgpunj	207	4	nuclear	nuclear	JJ
cord-306921-3afgpunj	207	5	protein	protein	NN
cord-306921-3afgpunj	207	6	was	be	VBD
cord-306921-3afgpunj	207	7	also	also	RB
cord-306921-3afgpunj	207	8	demonstrated	demonstrate	VBN
cord-306921-3afgpunj	207	9	to	to	TO
cord-306921-3afgpunj	207	10	translocate	translocate	VB
cord-306921-3afgpunj	207	11	to	to	IN
cord-306921-3afgpunj	207	12	the	the	DT
cord-306921-3afgpunj	207	13	cytoplasm	cytoplasm	NN
cord-306921-3afgpunj	207	14	during	during	IN
cord-306921-3afgpunj	207	15	EV	EV	NNP
cord-306921-3afgpunj	207	16	-	-	HYPH
cord-306921-3afgpunj	207	17	A71	A71	NNP
cord-306921-3afgpunj	207	18	infection	infection	NN
cord-306921-3afgpunj	207	19	where	where	WRB
cord-306921-3afgpunj	207	20	it	-PRON-	PRP
cord-306921-3afgpunj	207	21	binds	bind	VBZ
cord-306921-3afgpunj	207	22	to	to	IN
cord-306921-3afgpunj	207	23	the	the	DT
cord-306921-3afgpunj	207	24	viral	viral	JJ
cord-306921-3afgpunj	207	25	IRES	ires	JJ
cord-306921-3afgpunj	207	26	there	there	RB
cord-306921-3afgpunj	207	27	by	by	IN
cord-306921-3afgpunj	207	28	recruiting	recruit	VBG
cord-306921-3afgpunj	207	29	ribosomes	ribosome	NNS
cord-306921-3afgpunj	207	30	to	to	IN
cord-306921-3afgpunj	207	31	the	the	DT
cord-306921-3afgpunj	207	32	sites	site	NNS
cord-306921-3afgpunj	207	33	for	for	IN
cord-306921-3afgpunj	207	34	enhanced	enhance	VBN
cord-306921-3afgpunj	207	35	viral	viral	JJ
cord-306921-3afgpunj	207	36	protein	protein	NN
cord-306921-3afgpunj	207	37	synthesis	synthesis	NN
cord-306921-3afgpunj	207	38	;	;	:
cord-306921-3afgpunj	207	39	thus	thus	RB
cord-306921-3afgpunj	207	40	,	,	,
cord-306921-3afgpunj	207	41	acting	act	VBG
cord-306921-3afgpunj	207	42	as	as	IN
cord-306921-3afgpunj	207	43	a	a	DT
cord-306921-3afgpunj	207	44	positive	positive	JJ
cord-306921-3afgpunj	207	45	ITAF	ITAF	NNP
cord-306921-3afgpunj	207	46	[	[	-LRB-
cord-306921-3afgpunj	207	47	110	110	CD
cord-306921-3afgpunj	207	48	]	]	-RRB-
cord-306921-3afgpunj	207	49	.	.	.
cord-306921-3afgpunj	208	1	Studies	study	NNS
cord-306921-3afgpunj	208	2	by	by	IN
cord-306921-3afgpunj	208	3	Zhang	Zhang	NNP
cord-306921-3afgpunj	208	4	and	and	CC
cord-306921-3afgpunj	208	5	coworkers	coworker	NNS
cord-306921-3afgpunj	208	6	described	describe	VBD
cord-306921-3afgpunj	208	7	nuclear	nuclear	JJ
cord-306921-3afgpunj	208	8	factor	factor	NN
cord-306921-3afgpunj	208	9	cellular	cellular	JJ
cord-306921-3afgpunj	208	10	factor	factor	NN
cord-306921-3afgpunj	208	11	68-kDa	68-kda	CD
cord-306921-3afgpunj	208	12	Src	Src	NNP
cord-306921-3afgpunj	208	13	-	-	HYPH
cord-306921-3afgpunj	208	14	associated	associate	VBN
cord-306921-3afgpunj	208	15	protein	protein	NN
cord-306921-3afgpunj	208	16	in	in	IN
cord-306921-3afgpunj	208	17	mitosis	mitosis	NN
cord-306921-3afgpunj	208	18	(	(	-LRB-
cord-306921-3afgpunj	208	19	Sam68	Sam68	NNP
cord-306921-3afgpunj	208	20	)	)	-RRB-
cord-306921-3afgpunj	208	21	as	as	IN
cord-306921-3afgpunj	208	22	an	an	DT
cord-306921-3afgpunj	208	23	EV	EV	NNP
cord-306921-3afgpunj	208	24	-	-	HYPH
cord-306921-3afgpunj	208	25	A71	A71	NNP
cord-306921-3afgpunj	208	26	positive	positive	JJ
cord-306921-3afgpunj	208	27	ITAF	ITAF	NNP
cord-306921-3afgpunj	208	28	;	;	:
cord-306921-3afgpunj	208	29	upon	upon	IN
cord-306921-3afgpunj	208	30	translocation	translocation	NN
cord-306921-3afgpunj	208	31	into	into	IN
cord-306921-3afgpunj	208	32	the	the	DT
cord-306921-3afgpunj	208	33	cytoplasm	cytoplasm	NN
cord-306921-3afgpunj	208	34	[	[	-LRB-
cord-306921-3afgpunj	208	35	111	111	CD
cord-306921-3afgpunj	208	36	]	]	-RRB-
cord-306921-3afgpunj	208	37	.	.	.
cord-306921-3afgpunj	209	1	Human	human	JJ
cord-306921-3afgpunj	209	2	host	host	NN
cord-306921-3afgpunj	209	3	factors	factor	NNS
cord-306921-3afgpunj	209	4	-	-	:
cord-306921-3afgpunj	209	5	viral	viral	JJ
cord-306921-3afgpunj	209	6	protein	protein	NN
cord-306921-3afgpunj	209	7	studies	study	NNS
cord-306921-3afgpunj	209	8	identified	identify	VBD
cord-306921-3afgpunj	209	9	nuclear	nuclear	JJ
cord-306921-3afgpunj	209	10	factor	factor	NN
cord-306921-3afgpunj	209	11	;	;	:
cord-306921-3afgpunj	209	12	adenosine	adenosine	NN
cord-306921-3afgpunj	209	13	-	-	HYPH
cord-306921-3afgpunj	209	14	uridine	uridine	NN
cord-306921-3afgpunj	209	15	(	(	-LRB-
cord-306921-3afgpunj	209	16	AU)-rich	au)-rich	CD
cord-306921-3afgpunj	209	17	element	element	NN
cord-306921-3afgpunj	209	18	RNA	RNA	NNP
cord-306921-3afgpunj	209	19	binding	bind	VBG
cord-306921-3afgpunj	209	20	factor	factor	NN
cord-306921-3afgpunj	209	21	1	1	CD
cord-306921-3afgpunj	209	22	(	(	-LRB-
cord-306921-3afgpunj	209	23	AUF1	AUF1	NNP
cord-306921-3afgpunj	209	24	)	)	-RRB-
cord-306921-3afgpunj	209	25	is	be	VBZ
cord-306921-3afgpunj	209	26	targeted	target	VBN
cord-306921-3afgpunj	209	27	for	for	IN
cord-306921-3afgpunj	209	28	cleavage	cleavage	NN
cord-306921-3afgpunj	209	29	by	by	IN
cord-306921-3afgpunj	209	30	CV	cv	NN
cord-306921-3afgpunj	209	31	-	-	HYPH
cord-306921-3afgpunj	209	32	B3	B3	NNP
cord-306921-3afgpunj	209	33	viral	viral	JJ
cord-306921-3afgpunj	209	34	3C	3c	NN
cord-306921-3afgpunj	209	35	protease	protease	NN
cord-306921-3afgpunj	209	36	upon	upon	IN
cord-306921-3afgpunj	209	37	translocation	translocation	NN
cord-306921-3afgpunj	209	38	to	to	IN
cord-306921-3afgpunj	209	39	the	the	DT
cord-306921-3afgpunj	209	40	cytoplasm	cytoplasm	NN
cord-306921-3afgpunj	209	41	for	for	IN
cord-306921-3afgpunj	209	42	enhanced	enhanced	JJ
cord-306921-3afgpunj	209	43	stability	stability	NN
cord-306921-3afgpunj	209	44	of	of	IN
cord-306921-3afgpunj	209	45	the	the	DT
cord-306921-3afgpunj	209	46	IRES	IRES	NNP
cord-306921-3afgpunj	209	47	dependent	dependent	JJ
cord-306921-3afgpunj	209	48	viral	viral	JJ
cord-306921-3afgpunj	209	49	RNA	rna	NN
cord-306921-3afgpunj	209	50	production	production	NN
cord-306921-3afgpunj	209	51	[	[	-LRB-
cord-306921-3afgpunj	209	52	112	112	CD
cord-306921-3afgpunj	209	53	]	]	-RRB-
cord-306921-3afgpunj	209	54	,	,	,
cord-306921-3afgpunj	209	55	similar	similar	JJ
cord-306921-3afgpunj	209	56	antiviral	antiviral	JJ
cord-306921-3afgpunj	209	57	observations	observation	NNS
cord-306921-3afgpunj	209	58	were	be	VBD
cord-306921-3afgpunj	209	59	made	make	VBN
cord-306921-3afgpunj	209	60	for	for	IN
cord-306921-3afgpunj	209	61	poliovirus	poliovirus	NN
cord-306921-3afgpunj	209	62	,	,	,
cord-306921-3afgpunj	209	63	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	209	64	and	and	CC
cord-306921-3afgpunj	209	65	human	human	JJ
cord-306921-3afgpunj	209	66	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	209	67	[	[	-LRB-
cord-306921-3afgpunj	209	68	113	113	CD
cord-306921-3afgpunj	209	69	]	]	-RRB-
cord-306921-3afgpunj	209	70	.	.	.
cord-306921-3afgpunj	210	1	Rozovics	Rozovics	NNP
cord-306921-3afgpunj	210	2	and	and	CC
cord-306921-3afgpunj	210	3	colleagues	colleague	NNS
cord-306921-3afgpunj	210	4	reported	report	VBD
cord-306921-3afgpunj	210	5	a	a	DT
cord-306921-3afgpunj	210	6	3CD	3cd	CD
cord-306921-3afgpunj	210	7	dependent	dependent	JJ
cord-306921-3afgpunj	210	8	cleavage	cleavage	NN
cord-306921-3afgpunj	210	9	of	of	IN
cord-306921-3afgpunj	210	10	AUF1	AUF1	NNP
cord-306921-3afgpunj	210	11	during	during	IN
cord-306921-3afgpunj	210	12	poliovirus	poliovirus	NN
cord-306921-3afgpunj	210	13	and	and	CC
cord-306921-3afgpunj	210	14	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	210	15	infections	infection	NNS
cord-306921-3afgpunj	210	16	enhances	enhance	VBZ
cord-306921-3afgpunj	210	17	RNA	RNA	NNP
cord-306921-3afgpunj	210	18	replication	replication	NN
cord-306921-3afgpunj	210	19	[	[	-LRB-
cord-306921-3afgpunj	210	20	114	114	CD
cord-306921-3afgpunj	210	21	]	]	-RRB-
cord-306921-3afgpunj	210	22	.	.	.
cord-306921-3afgpunj	211	1	Interestingly	interestingly	RB
cord-306921-3afgpunj	211	2	,	,	,
cord-306921-3afgpunj	211	3	the	the	DT
cord-306921-3afgpunj	211	4	replication	replication	NN
cord-306921-3afgpunj	211	5	of	of	IN
cord-306921-3afgpunj	211	6	another	another	DT
cord-306921-3afgpunj	211	7	picornavirus	picornavirus	NN
cord-306921-3afgpunj	211	8	;	;	:
cord-306921-3afgpunj	211	9	EMCV	EMCV	NNP
cord-306921-3afgpunj	211	10	was	be	VBD
cord-306921-3afgpunj	211	11	not	not	RB
cord-306921-3afgpunj	211	12	affected	affect	VBN
cord-306921-3afgpunj	211	13	by	by	IN
cord-306921-3afgpunj	211	14	messenger	messenger	NN
cord-306921-3afgpunj	211	15	RNA	RNA	NNP
cord-306921-3afgpunj	211	16	decay	decay	NN
cord-306921-3afgpunj	211	17	protein	protein	NN
cord-306921-3afgpunj	211	18	:	:	:
cord-306921-3afgpunj	211	19	AUF1	AUF1	NNP
cord-306921-3afgpunj	212	1	as	as	IN
cord-306921-3afgpunj	212	2	observed	observe	VBN
cord-306921-3afgpunj	212	3	in	in	IN
cord-306921-3afgpunj	212	4	other	other	JJ
cord-306921-3afgpunj	212	5	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	212	6	,	,	,
cord-306921-3afgpunj	212	7	suggesting	suggest	VBG
cord-306921-3afgpunj	212	8	a	a	DT
cord-306921-3afgpunj	212	9	variance	variance	NN
cord-306921-3afgpunj	212	10	in	in	IN
cord-306921-3afgpunj	212	11	the	the	DT
cord-306921-3afgpunj	212	12	restriction	restriction	NN
cord-306921-3afgpunj	212	13	mechanism	mechanism	NN
cord-306921-3afgpunj	212	14	of	of	IN
cord-306921-3afgpunj	212	15	this	this	DT
cord-306921-3afgpunj	212	16	nuclear	nuclear	JJ
cord-306921-3afgpunj	212	17	factor	factor	NN
cord-306921-3afgpunj	212	18	[	[	-LRB-
cord-306921-3afgpunj	212	19	115	115	CD
cord-306921-3afgpunj	212	20	]	]	-RRB-
cord-306921-3afgpunj	212	21	.	.	.
cord-306921-3afgpunj	213	1	Investigating	investigate	VBG
cord-306921-3afgpunj	213	2	the	the	DT
cord-306921-3afgpunj	213	3	role	role	NN
cord-306921-3afgpunj	213	4	of	of	IN
cord-306921-3afgpunj	213	5	AUF1	AUF1	NNP
cord-306921-3afgpunj	213	6	in	in	IN
cord-306921-3afgpunj	213	7	EV	EV	NNP
cord-306921-3afgpunj	213	8	-	-	HYPH
cord-306921-3afgpunj	213	9	A71	A71	NNP
cord-306921-3afgpunj	213	10	infections	infection	NNS
cord-306921-3afgpunj	213	11	,	,	,
cord-306921-3afgpunj	213	12	Lin	Lin	NNP
cord-306921-3afgpunj	213	13	and	and	CC
cord-306921-3afgpunj	213	14	colleagues	colleague	NNS
cord-306921-3afgpunj	213	15	showed	show	VBD
cord-306921-3afgpunj	213	16	that	that	IN
cord-306921-3afgpunj	213	17	it	-PRON-	PRP
cord-306921-3afgpunj	213	18	relocates	relocate	VBZ
cord-306921-3afgpunj	213	19	to	to	IN
cord-306921-3afgpunj	213	20	the	the	DT
cord-306921-3afgpunj	213	21	cytoplasm	cytoplasm	NN
cord-306921-3afgpunj	213	22	during	during	IN
cord-306921-3afgpunj	213	23	infection	infection	NN
cord-306921-3afgpunj	213	24	where	where	WRB
cord-306921-3afgpunj	213	25	it	-PRON-	PRP
cord-306921-3afgpunj	213	26	binds	bind	VBZ
cord-306921-3afgpunj	213	27	to	to	IN
cord-306921-3afgpunj	213	28	the	the	DT
cord-306921-3afgpunj	213	29	viral	viral	JJ
cord-306921-3afgpunj	213	30	IRES	IRES	NNP
cord-306921-3afgpunj	213	31	and	and	CC
cord-306921-3afgpunj	213	32	restricts	restrict	VBZ
cord-306921-3afgpunj	213	33	viral	viral	JJ
cord-306921-3afgpunj	213	34	RNA	rna	NN
cord-306921-3afgpunj	213	35	production	production	NN
cord-306921-3afgpunj	213	36	[	[	-LRB-
cord-306921-3afgpunj	213	37	116	116	CD
cord-306921-3afgpunj	213	38	]	]	-RRB-
cord-306921-3afgpunj	213	39	.	.	.
cord-306921-3afgpunj	214	1	AUF1	AUF1	NNP
cord-306921-3afgpunj	214	2	is	be	VBZ
cord-306921-3afgpunj	214	3	the	the	DT
cord-306921-3afgpunj	214	4	only	only	JJ
cord-306921-3afgpunj	214	5	nuclear	nuclear	JJ
cord-306921-3afgpunj	214	6	factor	factor	NN
cord-306921-3afgpunj	214	7	which	which	WDT
cord-306921-3afgpunj	214	8	has	have	VBZ
cord-306921-3afgpunj	214	9	shown	show	VBN
cord-306921-3afgpunj	214	10	an	an	DT
cord-306921-3afgpunj	214	11	effect	effect	NN
cord-306921-3afgpunj	214	12	on	on	IN
cord-306921-3afgpunj	214	13	the	the	DT
cord-306921-3afgpunj	214	14	replication	replication	NN
cord-306921-3afgpunj	214	15	of	of	IN
cord-306921-3afgpunj	214	16	other	other	JJ
cord-306921-3afgpunj	214	17	picornaviruses	picornavirus	NNS
cord-306921-3afgpunj	214	18	;	;	,
cord-306921-3afgpunj	214	19	pointing	point	VBG
cord-306921-3afgpunj	214	20	to	to	IN
cord-306921-3afgpunj	214	21	its	-PRON-	PRP$
cord-306921-3afgpunj	214	22	possible	possible	JJ
cord-306921-3afgpunj	214	23	global	global	JJ
cord-306921-3afgpunj	214	24	role	role	NN
cord-306921-3afgpunj	214	25	during	during	IN
cord-306921-3afgpunj	214	26	these	these	DT
cord-306921-3afgpunj	214	27	viral	viral	JJ
cord-306921-3afgpunj	214	28	infections	infection	NNS
cord-306921-3afgpunj	214	29	,	,	,
cord-306921-3afgpunj	214	30	offering	offer	VBG
cord-306921-3afgpunj	214	31	a	a	DT
cord-306921-3afgpunj	214	32	possible	possible	JJ
cord-306921-3afgpunj	214	33	target	target	NN
cord-306921-3afgpunj	214	34	for	for	IN
cord-306921-3afgpunj	214	35	in	in	IN
cord-306921-3afgpunj	214	36	the	the	DT
cord-306921-3afgpunj	214	37	development	development	NN
cord-306921-3afgpunj	214	38	of	of	IN
cord-306921-3afgpunj	214	39	antivirals	antiviral	NNS
cord-306921-3afgpunj	214	40	against	against	IN
cord-306921-3afgpunj	214	41	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	214	42	.	.	.
cord-306921-3afgpunj	215	1	Other	other	JJ
cord-306921-3afgpunj	215	2	host	host	NN
cord-306921-3afgpunj	215	3	factors	factor	NNS
cord-306921-3afgpunj	215	4	described	describe	VBN
cord-306921-3afgpunj	215	5	to	to	TO
cord-306921-3afgpunj	215	6	be	be	VB
cord-306921-3afgpunj	215	7	involved	involve	VBN
cord-306921-3afgpunj	215	8	in	in	IN
cord-306921-3afgpunj	215	9	picornaviral	picornaviral	JJ
cord-306921-3afgpunj	215	10	translational	translational	JJ
cord-306921-3afgpunj	215	11	activity	activity	NN
cord-306921-3afgpunj	215	12	include	include	VBP
cord-306921-3afgpunj	215	13	;	;	:
cord-306921-3afgpunj	215	14	Misshapen	misshapen	JJ
cord-306921-3afgpunj	215	15	NCK	NCK	NNP
cord-306921-3afgpunj	215	16	-	-	HYPH
cord-306921-3afgpunj	215	17	related	relate	VBN
cord-306921-3afgpunj	215	18	kinase	kinase	NN
cord-306921-3afgpunj	215	19	(	(	-LRB-
cord-306921-3afgpunj	215	20	MINK	mink	NN
cord-306921-3afgpunj	215	21	)	)	-RRB-
cord-306921-3afgpunj	215	22	in	in	IN
cord-306921-3afgpunj	215	23	EV	EV	NNP
cord-306921-3afgpunj	215	24	-	-	HYPH
cord-306921-3afgpunj	215	25	A71	A71	NNP
cord-306921-3afgpunj	215	26	[	[	-LRB-
cord-306921-3afgpunj	215	27	117	117	CD
cord-306921-3afgpunj	215	28	]	]	-RRB-
cord-306921-3afgpunj	215	29	,	,	,
cord-306921-3afgpunj	215	30	heterogenous	heterogenous	JJ
cord-306921-3afgpunj	215	31	nuclear	nuclear	JJ
cord-306921-3afgpunj	215	32	ribonucleoprotein	ribonucleoprotein	NN
cord-306921-3afgpunj	215	33	C	C	NNP
cord-306921-3afgpunj	215	34	[	[	-LRB-
cord-306921-3afgpunj	215	35	118	118	CD
cord-306921-3afgpunj	215	36	]	]	-RRB-
cord-306921-3afgpunj	215	37	,	,	,
cord-306921-3afgpunj	215	38	La	La	NNP
cord-306921-3afgpunj	215	39	autoantigen	autoantigen	NNP
cord-306921-3afgpunj	215	40	in	in	IN
cord-306921-3afgpunj	215	41	hepatitis	hepatitis	NN
cord-306921-3afgpunj	215	42	C	C	NNP
cord-306921-3afgpunj	215	43	cap	cap	NN
cord-306921-3afgpunj	215	44	-	-	HYPH
cord-306921-3afgpunj	215	45	independent	independent	JJ
cord-306921-3afgpunj	215	46	translation	translation	NN
cord-306921-3afgpunj	215	47	[	[	-LRB-
cord-306921-3afgpunj	215	48	104	104	CD
cord-306921-3afgpunj	215	49	]	]	-RRB-
cord-306921-3afgpunj	215	50	,	,	,
cord-306921-3afgpunj	215	51	polypyrimidine	polypyrimidine	NNP
cord-306921-3afgpunj	215	52	tractbinding	tractbinde	VBG
cord-306921-3afgpunj	215	53	protein	protein	NN
cord-306921-3afgpunj	215	54	(	(	-LRB-
cord-306921-3afgpunj	215	55	PTB	PTB	NNP
cord-306921-3afgpunj	215	56	)	)	-RRB-
cord-306921-3afgpunj	215	57	and	and	CC
cord-306921-3afgpunj	215	58	poly(rC)-binding	poly(rC)-binding	NNP
cord-306921-3afgpunj	215	59	protein	protein	NN
cord-306921-3afgpunj	215	60	(	(	-LRB-
cord-306921-3afgpunj	215	61	PCBP	PCBP	NNP
cord-306921-3afgpunj	215	62	)	)	-RRB-
cord-306921-3afgpunj	215	63	for	for	IN
cord-306921-3afgpunj	215	64	IRES	ires	JJ
cord-306921-3afgpunj	215	65	dependent	dependent	JJ
cord-306921-3afgpunj	215	66	translation	translation	NN
cord-306921-3afgpunj	215	67	of	of	IN
cord-306921-3afgpunj	215	68	poliovirus	poliovirus	NN
cord-306921-3afgpunj	215	69	[	[	-LRB-
cord-306921-3afgpunj	215	70	119	119	CD
cord-306921-3afgpunj	215	71	]	]	-RRB-
cord-306921-3afgpunj	215	72	,	,	,
cord-306921-3afgpunj	215	73	double	double	JJ
cord-306921-3afgpunj	215	74	stranded	strand	VBN
cord-306921-3afgpunj	215	75	RNA	RNA	NNP
cord-306921-3afgpunj	215	76	binding	bind	VBG
cord-306921-3afgpunj	215	77	protein	protein	NN
cord-306921-3afgpunj	215	78	76	76	CD
cord-306921-3afgpunj	216	1	(	(	-LRB-
cord-306921-3afgpunj	216	2	DRBP76	DRBP76	NNP
cord-306921-3afgpunj	216	3	)	)	-RRB-
cord-306921-3afgpunj	216	4	acting	act	VBG
cord-306921-3afgpunj	216	5	as	as	IN
cord-306921-3afgpunj	216	6	a	a	DT
cord-306921-3afgpunj	216	7	negative	negative	JJ
cord-306921-3afgpunj	216	8	IRES	ires	JJ
cord-306921-3afgpunj	216	9	regulator	regulator	NN
cord-306921-3afgpunj	216	10	for	for	IN
cord-306921-3afgpunj	216	11	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	216	12	2	2	CD
cord-306921-3afgpunj	216	13	[	[	-LRB-
cord-306921-3afgpunj	216	14	120	120	CD
cord-306921-3afgpunj	216	15	,	,	,
cord-306921-3afgpunj	216	16	121	121	CD
cord-306921-3afgpunj	216	17	]	]	-RRB-
cord-306921-3afgpunj	216	18	,	,	,
cord-306921-3afgpunj	216	19	as	as	RB
cord-306921-3afgpunj	216	20	well	well	RB
cord-306921-3afgpunj	216	21	as	as	IN
cord-306921-3afgpunj	216	22	ploy(rC	ploy(rc	CD
cord-306921-3afgpunj	216	23	)	)	-RRB-
cord-306921-3afgpunj	216	24	binding	bind	VBG
cord-306921-3afgpunj	216	25	protein	protein	NN
cord-306921-3afgpunj	216	26	1	1	CD
cord-306921-3afgpunj	216	27	and	and	CC
cord-306921-3afgpunj	216	28	2	2	CD
cord-306921-3afgpunj	216	29	boosting	boost	VBG
cord-306921-3afgpunj	216	30	poliovirus	poliovirus	NN
cord-306921-3afgpunj	216	31	and	and	CC
cord-306921-3afgpunj	216	32	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	216	33	IRES	IRES	NNP
cord-306921-3afgpunj	216	34	dependent	dependent	JJ
cord-306921-3afgpunj	216	35	translation	translation	NN
cord-306921-3afgpunj	216	36	[	[	-LRB-
cord-306921-3afgpunj	216	37	122	122	CD
cord-306921-3afgpunj	216	38	]	]	-RRB-
cord-306921-3afgpunj	216	39	.	.	.
cord-306921-3afgpunj	217	1	The	the	DT
cord-306921-3afgpunj	217	2	mode	mode	NN
cord-306921-3afgpunj	217	3	of	of	IN
cord-306921-3afgpunj	217	4	action	action	NN
cord-306921-3afgpunj	217	5	of	of	IN
cord-306921-3afgpunj	217	6	enterovirus	enterovirus	NN
cord-306921-3afgpunj	217	7	IRES	IRES	NNP
cord-306921-3afgpunj	217	8	is	be	VBZ
cord-306921-3afgpunj	217	9	not	not	RB
cord-306921-3afgpunj	217	10	fully	fully	RB
cord-306921-3afgpunj	217	11	understood	understand	VBN
cord-306921-3afgpunj	217	12	as	as	IN
cord-306921-3afgpunj	217	13	seems	seem	VBZ
cord-306921-3afgpunj	217	14	to	to	TO
cord-306921-3afgpunj	217	15	be	be	VB
cord-306921-3afgpunj	217	16	a	a	DT
cord-306921-3afgpunj	217	17	myriad	myriad	NN
cord-306921-3afgpunj	217	18	of	of	IN
cord-306921-3afgpunj	217	19	host	host	NN
cord-306921-3afgpunj	217	20	nuclear	nuclear	JJ
cord-306921-3afgpunj	217	21	factors	factor	NNS
cord-306921-3afgpunj	217	22	involved	involve	VBN
cord-306921-3afgpunj	217	23	in	in	IN
cord-306921-3afgpunj	217	24	the	the	DT
cord-306921-3afgpunj	217	25	cap	cap	NN
cord-306921-3afgpunj	217	26	-	-	HYPH
cord-306921-3afgpunj	217	27	independent	independent	JJ
cord-306921-3afgpunj	217	28	viral	viral	JJ
cord-306921-3afgpunj	217	29	replication	replication	NN
cord-306921-3afgpunj	217	30	.	.	.
cord-306921-3afgpunj	218	1	There	there	EX
cord-306921-3afgpunj	218	2	is	be	VBZ
cord-306921-3afgpunj	218	3	need	need	NN
cord-306921-3afgpunj	218	4	for	for	IN
cord-306921-3afgpunj	218	5	further	further	JJ
cord-306921-3afgpunj	218	6	research	research	NN
cord-306921-3afgpunj	218	7	to	to	TO
cord-306921-3afgpunj	218	8	help	help	VB
cord-306921-3afgpunj	218	9	identify	identify	VB
cord-306921-3afgpunj	218	10	all	all	PDT
cord-306921-3afgpunj	218	11	the	the	DT
cord-306921-3afgpunj	218	12	host	host	NN
cord-306921-3afgpunj	218	13	factors	factor	NNS
cord-306921-3afgpunj	218	14	involved	involve	VBN
cord-306921-3afgpunj	218	15	in	in	IN
cord-306921-3afgpunj	218	16	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	218	17	IRES	IRES	NNP
cord-306921-3afgpunj	218	18	dependent	dependent	JJ
cord-306921-3afgpunj	218	19	RNA	RNA	NNP
cord-306921-3afgpunj	218	20	production	production	NN
cord-306921-3afgpunj	218	21	.	.	.
cord-306921-3afgpunj	219	1	Identifying	identify	VBG
cord-306921-3afgpunj	219	2	host	host	NN
cord-306921-3afgpunj	219	3	factors	factor	NNS
cord-306921-3afgpunj	219	4	that	that	WDT
cord-306921-3afgpunj	219	5	binds	bind	VBZ
cord-306921-3afgpunj	219	6	to	to	IN
cord-306921-3afgpunj	219	7	the	the	DT
cord-306921-3afgpunj	219	8	IRES	IRES	NNP
cord-306921-3afgpunj	219	9	during	during	IN
cord-306921-3afgpunj	219	10	enterovirus	enterovirus	NN
cord-306921-3afgpunj	219	11	cap	cap	NN
cord-306921-3afgpunj	219	12	-	-	HYPH
cord-306921-3afgpunj	219	13	independent	independent	JJ
cord-306921-3afgpunj	219	14	viral	viral	JJ
cord-306921-3afgpunj	219	15	translation	translation	NN
cord-306921-3afgpunj	219	16	will	will	MD
cord-306921-3afgpunj	219	17	be	be	VB
cord-306921-3afgpunj	219	18	key	key	JJ
cord-306921-3afgpunj	219	19	in	in	IN
cord-306921-3afgpunj	219	20	understanding	understand	VBG
cord-306921-3afgpunj	219	21	the	the	DT
cord-306921-3afgpunj	219	22	viral	viral	JJ
cord-306921-3afgpunj	219	23	replication	replication	NN
cord-306921-3afgpunj	219	24	cycle	cycle	NN
cord-306921-3afgpunj	219	25	.	.	.
cord-306921-3afgpunj	220	1	Neuronal	neuronal	JJ
cord-306921-3afgpunj	220	2	cell	cell	NN
cord-306921-3afgpunj	220	3	death	death	NN
cord-306921-3afgpunj	220	4	as	as	IN
cord-306921-3afgpunj	220	5	a	a	DT
cord-306921-3afgpunj	220	6	result	result	NN
cord-306921-3afgpunj	220	7	of	of	IN
cord-306921-3afgpunj	220	8	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	220	9	infections	infection	NNS
cord-306921-3afgpunj	220	10	have	have	VBP
cord-306921-3afgpunj	220	11	been	be	VBN
cord-306921-3afgpunj	220	12	observed	observe	VBN
cord-306921-3afgpunj	220	13	in	in	IN
cord-306921-3afgpunj	220	14	some	some	DT
cord-306921-3afgpunj	220	15	cases	case	NNS
cord-306921-3afgpunj	220	16	of	of	IN
cord-306921-3afgpunj	220	17	HFMD	HFMD	NNP
cord-306921-3afgpunj	220	18	[	[	-LRB-
cord-306921-3afgpunj	220	19	5	5	CD
cord-306921-3afgpunj	220	20	,	,	,
cord-306921-3afgpunj	220	21	123	123	CD
cord-306921-3afgpunj	220	22	]	]	-RRB-
cord-306921-3afgpunj	220	23	and	and	CC
cord-306921-3afgpunj	220	24	the	the	DT
cord-306921-3afgpunj	220	25	mechanism	mechanism	NN
cord-306921-3afgpunj	220	26	linked	link	VBN
cord-306921-3afgpunj	220	27	to	to	IN
cord-306921-3afgpunj	220	28	programmed	program	VBN
cord-306921-3afgpunj	220	29	cell	cell	NN
cord-306921-3afgpunj	220	30	death	death	NN
cord-306921-3afgpunj	220	31	.	.	.
cord-306921-3afgpunj	221	1	For	for	IN
cord-306921-3afgpunj	221	2	a	a	DT
cord-306921-3afgpunj	221	3	long	long	JJ
cord-306921-3afgpunj	221	4	it	-PRON-	PRP
cord-306921-3afgpunj	221	5	has	have	VBZ
cord-306921-3afgpunj	221	6	been	be	VBN
cord-306921-3afgpunj	221	7	a	a	DT
cord-306921-3afgpunj	221	8	common	common	JJ
cord-306921-3afgpunj	221	9	belief	belief	NN
cord-306921-3afgpunj	221	10	that	that	IN
cord-306921-3afgpunj	221	11	apoptosis	apoptosis	NN
cord-306921-3afgpunj	221	12	and	and	CC
cord-306921-3afgpunj	221	13	necrosis	necrosis	NN
cord-306921-3afgpunj	221	14	are	be	VBP
cord-306921-3afgpunj	221	15	the	the	DT
cord-306921-3afgpunj	221	16	major	major	JJ
cord-306921-3afgpunj	221	17	players	player	NNS
cord-306921-3afgpunj	221	18	in	in	IN
cord-306921-3afgpunj	221	19	programmed	programmed	JJ
cord-306921-3afgpunj	221	20	cell	cell	NN
cord-306921-3afgpunj	221	21	death	death	NN
cord-306921-3afgpunj	221	22	(	(	-LRB-
cord-306921-3afgpunj	221	23	reviewed	review	VBN
cord-306921-3afgpunj	221	24	[	[	-LRB-
cord-306921-3afgpunj	221	25	124	124	CD
cord-306921-3afgpunj	221	26	]	]	-RRB-
cord-306921-3afgpunj	221	27	)	)	-RRB-
cord-306921-3afgpunj	221	28	.	.	.
cord-306921-3afgpunj	222	1	Other	other	JJ
cord-306921-3afgpunj	222	2	mechanisms	mechanism	NNS
cord-306921-3afgpunj	222	3	including	include	VBG
cord-306921-3afgpunj	222	4	pyroptosis	pyroptosis	NNP
cord-306921-3afgpunj	222	5	and	and	CC
cord-306921-3afgpunj	222	6	necroptosis	necroptosis	NNP
cord-306921-3afgpunj	222	7	have	have	VBP
cord-306921-3afgpunj	222	8	been	be	VBN
cord-306921-3afgpunj	222	9	described	describe	VBN
cord-306921-3afgpunj	222	10	to	to	TO
cord-306921-3afgpunj	222	11	play	play	VB
cord-306921-3afgpunj	222	12	a	a	DT
cord-306921-3afgpunj	222	13	role	role	NN
cord-306921-3afgpunj	222	14	in	in	IN
cord-306921-3afgpunj	222	15	complementing	complement	VBG
cord-306921-3afgpunj	222	16	apoptosis	apoptosis	NN
cord-306921-3afgpunj	222	17	in	in	IN
cord-306921-3afgpunj	222	18	restricting	restrict	VBG
cord-306921-3afgpunj	222	19	viral	viral	JJ
cord-306921-3afgpunj	222	20	infections	infection	NNS
cord-306921-3afgpunj	222	21	[	[	-LRB-
cord-306921-3afgpunj	222	22	125	125	CD
cord-306921-3afgpunj	222	23	]	]	-RRB-
cord-306921-3afgpunj	223	1	[	[	-LRB-
cord-306921-3afgpunj	223	2	126	126	CD
cord-306921-3afgpunj	223	3	]	]	-RRB-
cord-306921-3afgpunj	223	4	[	[	-LRB-
cord-306921-3afgpunj	223	5	127	127	CD
cord-306921-3afgpunj	223	6	]	]	-RRB-
cord-306921-3afgpunj	223	7	[	[	-LRB-
cord-306921-3afgpunj	223	8	128	128	CD
cord-306921-3afgpunj	223	9	]	]	-RRB-
cord-306921-3afgpunj	223	10	.	.	.
cord-306921-3afgpunj	224	1	The	the	DT
cord-306921-3afgpunj	224	2	process	process	NN
cord-306921-3afgpunj	224	3	of	of	IN
cord-306921-3afgpunj	224	4	caspace-1	caspace-1	NNP
cord-306921-3afgpunj	224	5	induced	induce	VBN
cord-306921-3afgpunj	224	6	pyroptosis	pyroptosis	NN
cord-306921-3afgpunj	224	7	was	be	VBD
cord-306921-3afgpunj	224	8	first	first	RB
cord-306921-3afgpunj	224	9	described	describe	VBN
cord-306921-3afgpunj	224	10	in	in	IN
cord-306921-3afgpunj	224	11	Salmonella	Salmonella	NNP
cord-306921-3afgpunj	224	12	enterica	enterica	NNP
cord-306921-3afgpunj	224	13	serovar	serovar	NNP
cord-306921-3afgpunj	225	1	Typhimurium	typhimurium	NN
cord-306921-3afgpunj	225	2	bacteria	bacteria	NNS
cord-306921-3afgpunj	225	3	[	[	-LRB-
cord-306921-3afgpunj	225	4	129	129	CD
cord-306921-3afgpunj	225	5	]	]	-RRB-
cord-306921-3afgpunj	225	6	;	;	:
cord-306921-3afgpunj	226	1	and	and	CC
cord-306921-3afgpunj	226	2	has	have	VBZ
cord-306921-3afgpunj	226	3	been	be	VBN
cord-306921-3afgpunj	226	4	elucidated	elucidate	VBN
cord-306921-3afgpunj	226	5	to	to	TO
cord-306921-3afgpunj	226	6	be	be	VB
cord-306921-3afgpunj	226	7	used	use	VBN
cord-306921-3afgpunj	226	8	by	by	IN
cord-306921-3afgpunj	226	9	other	other	JJ
cord-306921-3afgpunj	226	10	species	specie	NNS
cord-306921-3afgpunj	226	11	of	of	IN
cord-306921-3afgpunj	226	12	bacteria	bacteria	NNS
cord-306921-3afgpunj	226	13	to	to	TO
cord-306921-3afgpunj	226	14	escape	escape	VB
cord-306921-3afgpunj	226	15	inflammasome	inflammasome	NNP
cord-306921-3afgpunj	226	16	and	and	CC
cord-306921-3afgpunj	226	17	stimulate	stimulate	VB
cord-306921-3afgpunj	226	18	cell	cell	NN
cord-306921-3afgpunj	226	19	death	death	NN
cord-306921-3afgpunj	226	20	(	(	-LRB-
cord-306921-3afgpunj	226	21	reviewed	review	VBN
cord-306921-3afgpunj	226	22	[	[	-LRB-
cord-306921-3afgpunj	226	23	130	130	CD
cord-306921-3afgpunj	226	24	]	]	-RRB-
cord-306921-3afgpunj	226	25	)	)	-RRB-
cord-306921-3afgpunj	226	26	.	.	.
cord-306921-3afgpunj	227	1	Pyroptosis	pyroptosis	NN
cord-306921-3afgpunj	227	2	;	;	,
cord-306921-3afgpunj	227	3	inflammatory	inflammatory	JJ
cord-306921-3afgpunj	227	4	programmed	programmed	JJ
cord-306921-3afgpunj	227	5	cell	cell	NN
cord-306921-3afgpunj	227	6	death	death	NN
cord-306921-3afgpunj	227	7	,	,	,
cord-306921-3afgpunj	227	8	has	have	VBZ
cord-306921-3afgpunj	227	9	been	be	VBN
cord-306921-3afgpunj	227	10	linked	link	VBN
cord-306921-3afgpunj	227	11	to	to	IN
cord-306921-3afgpunj	227	12	cell	cell	NN
cord-306921-3afgpunj	227	13	death	death	NN
cord-306921-3afgpunj	227	14	during	during	IN
cord-306921-3afgpunj	227	15	EV	EV	NNP
cord-306921-3afgpunj	227	16	-	-	HYPH
cord-306921-3afgpunj	227	17	A71	A71	NNP
cord-306921-3afgpunj	227	18	infections	infection	NNS
cord-306921-3afgpunj	227	19	in	in	IN
cord-306921-3afgpunj	227	20	neuronal	neuronal	JJ
cord-306921-3afgpunj	227	21	cell	cell	NN
cord-306921-3afgpunj	227	22	lines	line	NNS
cord-306921-3afgpunj	227	23	[	[	-LRB-
cord-306921-3afgpunj	227	24	131	131	CD
cord-306921-3afgpunj	227	25	]	]	-RRB-
cord-306921-3afgpunj	227	26	.	.	.
cord-306921-3afgpunj	228	1	AIM2	AIM2	NNP
cord-306921-3afgpunj	228	2	mediated	mediate	VBN
cord-306921-3afgpunj	228	3	inflammation	inflammation	NN
cord-306921-3afgpunj	228	4	had	have	VBD
cord-306921-3afgpunj	228	5	been	be	VBN
cord-306921-3afgpunj	228	6	linked	link	VBN
cord-306921-3afgpunj	228	7	to	to	IN
cord-306921-3afgpunj	228	8	the	the	DT
cord-306921-3afgpunj	228	9	pyroptosis	pyroptosis	NN
cord-306921-3afgpunj	228	10	during	during	IN
cord-306921-3afgpunj	228	11	EV	EV	NNP
cord-306921-3afgpunj	228	12	-	-	HYPH
cord-306921-3afgpunj	228	13	A71	A71	NNP
cord-306921-3afgpunj	228	14	infections	infection	NNS
cord-306921-3afgpunj	228	15	as	as	IN
cord-306921-3afgpunj	228	16	it	-PRON-	PRP
cord-306921-3afgpunj	228	17	was	be	VBD
cord-306921-3afgpunj	228	18	up	up	RB
cord-306921-3afgpunj	228	19	-	-	HYPH
cord-306921-3afgpunj	228	20	regulated	regulate	VBN
cord-306921-3afgpunj	228	21	as	as	RB
cord-306921-3afgpunj	228	22	well	well	RB
cord-306921-3afgpunj	228	23	as	as	IN
cord-306921-3afgpunj	228	24	AIM2	AIM2	NNP
cord-306921-3afgpunj	228	25	downstream	downstream	RB
cord-306921-3afgpunj	228	26	stimulated	stimulate	VBN
cord-306921-3afgpunj	228	27	genes	gene	NNS
cord-306921-3afgpunj	228	28	such	such	JJ
cord-306921-3afgpunj	228	29	as	as	IN
cord-306921-3afgpunj	228	30	CARD16	CARD16	NNP
cord-306921-3afgpunj	228	31	,	,	,
cord-306921-3afgpunj	228	32	caspase-1	caspase-1	NNP
cord-306921-3afgpunj	228	33	and	and	CC
cord-306921-3afgpunj	228	34	IL-1β	IL-1β	NNP
cord-306921-3afgpunj	228	35	during	during	IN
cord-306921-3afgpunj	228	36	viral	viral	JJ
cord-306921-3afgpunj	228	37	infection	infection	NN
cord-306921-3afgpunj	228	38	in	in	IN
cord-306921-3afgpunj	228	39	neuronal	neuronal	JJ
cord-306921-3afgpunj	228	40	cell	cell	NN
cord-306921-3afgpunj	228	41	lines	line	NNS
cord-306921-3afgpunj	228	42	(	(	-LRB-
cord-306921-3afgpunj	228	43	SK	SK	NNP
cord-306921-3afgpunj	228	44	-	-	HYPH
cord-306921-3afgpunj	228	45	N	N	NNP
cord-306921-3afgpunj	228	46	-	-	HYPH
cord-306921-3afgpunj	228	47	SH	SH	NNP
cord-306921-3afgpunj	228	48	)	)	-RRB-
cord-306921-3afgpunj	228	49	[	[	-LRB-
cord-306921-3afgpunj	228	50	132	132	CD
cord-306921-3afgpunj	228	51	]	]	-RRB-
cord-306921-3afgpunj	228	52	.	.	.
cord-306921-3afgpunj	229	1	Yogarajah	Yogarajah	NNP
cord-306921-3afgpunj	229	2	and	and	CC
cord-306921-3afgpunj	229	3	coworkers	coworker	NNS
cord-306921-3afgpunj	229	4	recently	recently	RB
cord-306921-3afgpunj	229	5	identified	identify	VBD
cord-306921-3afgpunj	229	6	radical	radical	JJ
cord-306921-3afgpunj	229	7	S	s	NN
cord-306921-3afgpunj	229	8	-	-	HYPH
cord-306921-3afgpunj	229	9	adenosylmethionine	adenosylmethionine	NN
cord-306921-3afgpunj	229	10	domain	domain	NN
cord-306921-3afgpunj	229	11	containing	contain	VBG
cord-306921-3afgpunj	229	12	2	2	CD
cord-306921-3afgpunj	229	13	(	(	-LRB-
cord-306921-3afgpunj	229	14	RSAD2	RSAD2	NNPS
cord-306921-3afgpunj	229	15	)	)	-RRB-
cord-306921-3afgpunj	229	16	and	and	CC
cord-306921-3afgpunj	229	17	Absent	Absent	NNP
cord-306921-3afgpunj	229	18	in	in	IN
cord-306921-3afgpunj	229	19	melanoma	melanoma	NN
cord-306921-3afgpunj	229	20	2	2	CD
cord-306921-3afgpunj	229	21	(	(	-LRB-
cord-306921-3afgpunj	229	22	AIM2	AIM2	NNP
cord-306921-3afgpunj	229	23	)	)	-RRB-
cord-306921-3afgpunj	229	24	to	to	TO
cord-306921-3afgpunj	229	25	be	be	VB
cord-306921-3afgpunj	229	26	modulating	modulate	VBG
cord-306921-3afgpunj	229	27	EV	EV	NNP
cord-306921-3afgpunj	229	28	-	-	HYPH
cord-306921-3afgpunj	229	29	A71	A71	NNP
cord-306921-3afgpunj	229	30	and	and	CC
cord-306921-3afgpunj	229	31	CV	CV	NNP
cord-306921-3afgpunj	229	32	-	-	HYPH
cord-306921-3afgpunj	229	33	A16	a16	NN
cord-306921-3afgpunj	229	34	infections	infection	NNS
cord-306921-3afgpunj	229	35	of	of	IN
cord-306921-3afgpunj	229	36	the	the	DT
cord-306921-3afgpunj	229	37	neuronal	neuronal	JJ
cord-306921-3afgpunj	229	38	cells	cell	NNS
cord-306921-3afgpunj	229	39	[	[	-LRB-
cord-306921-3afgpunj	229	40	133	133	CD
cord-306921-3afgpunj	229	41	]	]	-RRB-
cord-306921-3afgpunj	229	42	.	.	.
cord-306921-3afgpunj	230	1	Consistent	consistent	JJ
cord-306921-3afgpunj	230	2	with	with	IN
cord-306921-3afgpunj	230	3	previous	previous	JJ
cord-306921-3afgpunj	230	4	findings	finding	NNS
cord-306921-3afgpunj	230	5	from	from	IN
cord-306921-3afgpunj	230	6	the	the	DT
cord-306921-3afgpunj	230	7	same	same	JJ
cord-306921-3afgpunj	230	8	research	research	NN
cord-306921-3afgpunj	230	9	group	group	NN
cord-306921-3afgpunj	230	10	;	;	:
cord-306921-3afgpunj	230	11	the	the	DT
cord-306921-3afgpunj	230	12	upregulation	upregulation	NN
cord-306921-3afgpunj	230	13	of	of	IN
cord-306921-3afgpunj	230	14	AIM2	AIM2	NNP
cord-306921-3afgpunj	230	15	resulted	result	VBD
cord-306921-3afgpunj	230	16	in	in	IN
cord-306921-3afgpunj	230	17	reduced	reduce	VBN
cord-306921-3afgpunj	230	18	viral	viral	JJ
cord-306921-3afgpunj	230	19	replication	replication	NN
cord-306921-3afgpunj	230	20	[	[	-LRB-
cord-306921-3afgpunj	230	21	132	132	CD
cord-306921-3afgpunj	230	22	]	]	-RRB-
cord-306921-3afgpunj	230	23	.	.	.
cord-306921-3afgpunj	231	1	The	the	DT
cord-306921-3afgpunj	231	2	results	result	NNS
cord-306921-3afgpunj	231	3	from	from	IN
cord-306921-3afgpunj	231	4	this	this	DT
cord-306921-3afgpunj	231	5	study	study	NN
cord-306921-3afgpunj	231	6	points	point	VBZ
cord-306921-3afgpunj	231	7	to	to	IN
cord-306921-3afgpunj	231	8	mechanisms	mechanism	NNS
cord-306921-3afgpunj	231	9	involved	involve	VBN
cord-306921-3afgpunj	231	10	in	in	IN
cord-306921-3afgpunj	231	11	the	the	DT
cord-306921-3afgpunj	231	12	neuronal	neuronal	JJ
cord-306921-3afgpunj	231	13	complications	complication	NNS
cord-306921-3afgpunj	231	14	observed	observe	VBN
cord-306921-3afgpunj	231	15	in	in	IN
cord-306921-3afgpunj	231	16	the	the	DT
cord-306921-3afgpunj	231	17	fatal	fatal	JJ
cord-306921-3afgpunj	231	18	cases	case	NNS
cord-306921-3afgpunj	231	19	of	of	IN
cord-306921-3afgpunj	231	20	EV	EV	NNP
cord-306921-3afgpunj	231	21	-	-	HYPH
cord-306921-3afgpunj	231	22	A71	A71	NNP
cord-306921-3afgpunj	231	23	infections	infection	NNS
cord-306921-3afgpunj	231	24	which	which	WDT
cord-306921-3afgpunj	231	25	are	be	VBP
cord-306921-3afgpunj	231	26	not	not	RB
cord-306921-3afgpunj	231	27	observed	observe	VBN
cord-306921-3afgpunj	231	28	during	during	IN
cord-306921-3afgpunj	231	29	CV	CV	NNP
cord-306921-3afgpunj	231	30	-	-	HYPH
cord-306921-3afgpunj	231	31	A16	A16	NNP
cord-306921-3afgpunj	231	32	infections	infection	NNS
cord-306921-3afgpunj	231	33	.	.	.
cord-306921-3afgpunj	232	1	This	this	DT
cord-306921-3afgpunj	232	2	observation	observation	NN
cord-306921-3afgpunj	232	3	is	be	VBZ
cord-306921-3afgpunj	232	4	postulated	postulate	VBN
cord-306921-3afgpunj	232	5	to	to	TO
cord-306921-3afgpunj	232	6	be	be	VB
cord-306921-3afgpunj	232	7	as	as	IN
cord-306921-3afgpunj	232	8	a	a	DT
cord-306921-3afgpunj	232	9	result	result	NN
cord-306921-3afgpunj	232	10	of	of	IN
cord-306921-3afgpunj	232	11	differential	differential	JJ
cord-306921-3afgpunj	232	12	stimulation	stimulation	NN
cord-306921-3afgpunj	232	13	of	of	IN
cord-306921-3afgpunj	232	14	host	host	NN
cord-306921-3afgpunj	232	15	factors	factor	NNS
cord-306921-3afgpunj	232	16	during	during	IN
cord-306921-3afgpunj	232	17	viral	viral	JJ
cord-306921-3afgpunj	232	18	infections	infection	NNS
cord-306921-3afgpunj	232	19	by	by	IN
cord-306921-3afgpunj	232	20	the	the	DT
cord-306921-3afgpunj	232	21	viral	viral	JJ
cord-306921-3afgpunj	232	22	5'non	5'non	CD
cord-306921-3afgpunj	232	23	-	-	HYPH
cord-306921-3afgpunj	232	24	tranlsated	tranlsate	VBN
cord-306921-3afgpunj	232	25	regions	region	NNS
cord-306921-3afgpunj	232	26	[	[	-LRB-
cord-306921-3afgpunj	232	27	133	133	CD
cord-306921-3afgpunj	232	28	]	]	-RRB-
cord-306921-3afgpunj	232	29	.	.	.
cord-306921-3afgpunj	233	1	Involvement	involvement	NN
cord-306921-3afgpunj	233	2	of	of	IN
cord-306921-3afgpunj	233	3	pyroptosis	pyroptosis	NN
cord-306921-3afgpunj	233	4	during	during	IN
cord-306921-3afgpunj	233	5	viral	viral	JJ
cord-306921-3afgpunj	233	6	infection	infection	NN
cord-306921-3afgpunj	233	7	has	have	VBZ
cord-306921-3afgpunj	233	8	been	be	VBN
cord-306921-3afgpunj	233	9	reported	report	VBN
cord-306921-3afgpunj	233	10	for	for	IN
cord-306921-3afgpunj	233	11	other	other	JJ
cord-306921-3afgpunj	233	12	viruses	virus	NNS
cord-306921-3afgpunj	233	13	including	include	VBG
cord-306921-3afgpunj	233	14	;	;	:
cord-306921-3afgpunj	233	15	encephalomyocarditis	encephalomyocarditis	NNP
cord-306921-3afgpunj	233	16	virus	virus	NN
cord-306921-3afgpunj	233	17	(	(	-LRB-
cord-306921-3afgpunj	233	18	EMCV	EMCV	NNP
cord-306921-3afgpunj	233	19	)	)	-RRB-
cord-306921-3afgpunj	233	20	[	[	-LRB-
cord-306921-3afgpunj	233	21	134	134	CD
cord-306921-3afgpunj	233	22	]	]	-RRB-
cord-306921-3afgpunj	233	23	,	,	,
cord-306921-3afgpunj	233	24	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	233	25	[	[	-LRB-
cord-306921-3afgpunj	233	26	135	135	CD
cord-306921-3afgpunj	233	27	]	]	-RRB-
cord-306921-3afgpunj	233	28	and	and	CC
cord-306921-3afgpunj	233	29	adenoviruses	adenovirus	NNS
cord-306921-3afgpunj	233	30	[	[	-LRB-
cord-306921-3afgpunj	233	31	136	136	CD
cord-306921-3afgpunj	233	32	]	]	-RRB-
cord-306921-3afgpunj	233	33	.	.	.
cord-306921-3afgpunj	234	1	Viruses	virus	NNS
cord-306921-3afgpunj	234	2	are	be	VBP
cord-306921-3afgpunj	234	3	known	know	VBN
cord-306921-3afgpunj	234	4	to	to	TO
cord-306921-3afgpunj	234	5	target	target	VB
cord-306921-3afgpunj	234	6	various	various	JJ
cord-306921-3afgpunj	234	7	host	host	NN
cord-306921-3afgpunj	234	8	cellular	cellular	JJ
cord-306921-3afgpunj	234	9	factors	factor	NNS
cord-306921-3afgpunj	234	10	for	for	IN
cord-306921-3afgpunj	234	11	effective	effective	JJ
cord-306921-3afgpunj	234	12	and	and	CC
cord-306921-3afgpunj	234	13	efficient	efficient	JJ
cord-306921-3afgpunj	234	14	replication	replication	NN
cord-306921-3afgpunj	234	15	.	.	.
cord-306921-3afgpunj	235	1	Several	several	JJ
cord-306921-3afgpunj	235	2	viruses	virus	NNS
cord-306921-3afgpunj	235	3	have	have	VBP
cord-306921-3afgpunj	235	4	been	be	VBN
cord-306921-3afgpunj	235	5	shown	show	VBN
cord-306921-3afgpunj	235	6	to	to	TO
cord-306921-3afgpunj	235	7	target	target	VB
cord-306921-3afgpunj	235	8	human	human	JJ
cord-306921-3afgpunj	235	9	host	host	NN
cord-306921-3afgpunj	235	10	cell	cell	NN
cord-306921-3afgpunj	235	11	cycle	cycle	NN
cord-306921-3afgpunj	235	12	;	;	:
cord-306921-3afgpunj	235	13	arresting	arrest	VBG
cord-306921-3afgpunj	235	14	the	the	DT
cord-306921-3afgpunj	235	15	cell	cell	NN
cord-306921-3afgpunj	235	16	division	division	NN
cord-306921-3afgpunj	235	17	thereby	thereby	RB
cord-306921-3afgpunj	235	18	avoiding	avoid	VBG
cord-306921-3afgpunj	235	19	competition	competition	NN
cord-306921-3afgpunj	235	20	from	from	IN
cord-306921-3afgpunj	235	21	the	the	DT
cord-306921-3afgpunj	235	22	dividing	divide	VBG
cord-306921-3afgpunj	235	23	cells	cell	NNS
cord-306921-3afgpunj	235	24	for	for	IN
cord-306921-3afgpunj	235	25	their	-PRON-	PRP$
cord-306921-3afgpunj	235	26	efficient	efficient	JJ
cord-306921-3afgpunj	235	27	genome	genome	NN
cord-306921-3afgpunj	235	28	replication	replication	NN
cord-306921-3afgpunj	235	29	.	.	.
cord-306921-3afgpunj	236	1	DNA	dna	NN
cord-306921-3afgpunj	236	2	viruses	virus	NNS
cord-306921-3afgpunj	236	3	have	have	VBP
cord-306921-3afgpunj	236	4	been	be	VBN
cord-306921-3afgpunj	236	5	shown	show	VBN
cord-306921-3afgpunj	236	6	to	to	TO
cord-306921-3afgpunj	236	7	have	have	VB
cord-306921-3afgpunj	236	8	the	the	DT
cord-306921-3afgpunj	236	9	ability	ability	NN
cord-306921-3afgpunj	236	10	of	of	IN
cord-306921-3afgpunj	236	11	entering	enter	VBG
cord-306921-3afgpunj	236	12	the	the	DT
cord-306921-3afgpunj	236	13	cell	cell	NN
cord-306921-3afgpunj	236	14	cycle	cycle	NN
cord-306921-3afgpunj	236	15	S	S	NNP
cord-306921-3afgpunj	236	16	phase	phase	NN
cord-306921-3afgpunj	236	17	and	and	CC
cord-306921-3afgpunj	236	18	arresting	arrest	VBG
cord-306921-3afgpunj	236	19	cycle	cycle	NN
cord-306921-3afgpunj	236	20	for	for	IN
cord-306921-3afgpunj	236	21	viral	viral	JJ
cord-306921-3afgpunj	236	22	replication	replication	NN
cord-306921-3afgpunj	236	23	;	;	:
cord-306921-3afgpunj	236	24	for	for	IN
cord-306921-3afgpunj	236	25	example	example	NN
cord-306921-3afgpunj	236	26	Simian	simian	JJ
cord-306921-3afgpunj	236	27	Virus	Virus	NNP
cord-306921-3afgpunj	236	28	40	40	CD
cord-306921-3afgpunj	236	29	[	[	-LRB-
cord-306921-3afgpunj	236	30	137	137	CD
cord-306921-3afgpunj	236	31	]	]	-RRB-
cord-306921-3afgpunj	236	32	,	,	,
cord-306921-3afgpunj	236	33	human	human	JJ
cord-306921-3afgpunj	236	34	papillomavirus	papillomavirus	NN
cord-306921-3afgpunj	236	35	16	16	CD
cord-306921-3afgpunj	236	36	and	and	CC
cord-306921-3afgpunj	236	37	18	18	CD
cord-306921-3afgpunj	236	38	viral	viral	JJ
cord-306921-3afgpunj	236	39	protein	protein	NN
cord-306921-3afgpunj	236	40	E6	e6	NN
cord-306921-3afgpunj	236	41	interacts	interact	VBZ
cord-306921-3afgpunj	236	42	with	with	IN
cord-306921-3afgpunj	236	43	p53	p53	NN
cord-306921-3afgpunj	236	44	[	[	-LRB-
cord-306921-3afgpunj	236	45	138	138	CD
cord-306921-3afgpunj	236	46	]	]	-RRB-
cord-306921-3afgpunj	236	47	as	as	RB
cord-306921-3afgpunj	236	48	well	well	RB
cord-306921-3afgpunj	236	49	as	as	IN
cord-306921-3afgpunj	236	50	herpes	herpes	NN
cord-306921-3afgpunj	236	51	simplex	simplex	NN
cord-306921-3afgpunj	236	52	virus	virus	NN
cord-306921-3afgpunj	236	53	ability	ability	NN
cord-306921-3afgpunj	236	54	to	to	TO
cord-306921-3afgpunj	236	55	block	block	VB
cord-306921-3afgpunj	236	56	cell	cell	NN
cord-306921-3afgpunj	236	57	cycle	cycle	NN
cord-306921-3afgpunj	236	58	is	be	VBZ
cord-306921-3afgpunj	236	59	reviewed	review	VBN
cord-306921-3afgpunj	236	60	in	in	IN
cord-306921-3afgpunj	236	61	details	detail	NNS
cord-306921-3afgpunj	236	62	by	by	IN
cord-306921-3afgpunj	236	63	Flemington	Flemington	NNP
cord-306921-3afgpunj	236	64	and	and	CC
cord-306921-3afgpunj	236	65	colleagues	colleague	NNS
cord-306921-3afgpunj	236	66	[	[	-LRB-
cord-306921-3afgpunj	236	67	139	139	CD
cord-306921-3afgpunj	236	68	]	]	-RRB-
cord-306921-3afgpunj	236	69	,	,	,
cord-306921-3afgpunj	236	70	have	have	VBP
cord-306921-3afgpunj	236	71	been	be	VBN
cord-306921-3afgpunj	236	72	shown	show	VBN
cord-306921-3afgpunj	236	73	to	to	TO
cord-306921-3afgpunj	236	74	usurp	usurp	VB
cord-306921-3afgpunj	236	75	the	the	DT
cord-306921-3afgpunj	236	76	cell	cell	NN
cord-306921-3afgpunj	236	77	cycle	cycle	NN
cord-306921-3afgpunj	236	78	for	for	IN
cord-306921-3afgpunj	236	79	efficient	efficient	JJ
cord-306921-3afgpunj	236	80	viral	viral	JJ
cord-306921-3afgpunj	236	81	replication	replication	NN
cord-306921-3afgpunj	236	82	process	process	NN
cord-306921-3afgpunj	236	83	.	.	.
cord-306921-3afgpunj	237	1	Infectious	infectious	JJ
cord-306921-3afgpunj	237	2	bronchitis	bronchitis	NN
cord-306921-3afgpunj	237	3	virus	virus	NN
cord-306921-3afgpunj	237	4	(	(	-LRB-
cord-306921-3afgpunj	237	5	IBV	IBV	NNP
cord-306921-3afgpunj	237	6	)	)	-RRB-
cord-306921-3afgpunj	237	7	;	;	:
cord-306921-3afgpunj	237	8	a	a	DT
cord-306921-3afgpunj	237	9	coronavirus	coronavirus	NN
cord-306921-3afgpunj	237	10	was	be	VBD
cord-306921-3afgpunj	237	11	shown	show	VBN
cord-306921-3afgpunj	237	12	by	by	IN
cord-306921-3afgpunj	237	13	Li	Li	NNP
cord-306921-3afgpunj	237	14	and	and	CC
cord-306921-3afgpunj	237	15	colleagues	colleague	NNS
cord-306921-3afgpunj	237	16	as	as	RB
cord-306921-3afgpunj	237	17	well	well	RB
cord-306921-3afgpunj	237	18	as	as	IN
cord-306921-3afgpunj	237	19	Dove	Dove	NNP
cord-306921-3afgpunj	237	20	and	and	CC
cord-306921-3afgpunj	237	21	coworkers	coworker	NNS
cord-306921-3afgpunj	237	22	to	to	TO
cord-306921-3afgpunj	237	23	induce	induce	VB
cord-306921-3afgpunj	237	24	cell	cell	NN
cord-306921-3afgpunj	237	25	cycle	cycle	NN
cord-306921-3afgpunj	237	26	arrest	arrest	NN
cord-306921-3afgpunj	237	27	during	during	IN
cord-306921-3afgpunj	237	28	the	the	DT
cord-306921-3afgpunj	237	29	S	S	NNP
cord-306921-3afgpunj	237	30	and	and	CC
cord-306921-3afgpunj	237	31	G(2)/M	G(2)/M	NNP
cord-306921-3afgpunj	237	32	phases	phase	NNS
cord-306921-3afgpunj	237	33	for	for	IN
cord-306921-3afgpunj	237	34	improved	improve	VBN
cord-306921-3afgpunj	237	35	viral	viral	JJ
cord-306921-3afgpunj	237	36	replication	replication	NN
cord-306921-3afgpunj	237	37	[	[	-LRB-
cord-306921-3afgpunj	237	38	140	140	CD
cord-306921-3afgpunj	237	39	,	,	,
cord-306921-3afgpunj	237	40	141	141	CD
cord-306921-3afgpunj	237	41	]	]	-RRB-
cord-306921-3afgpunj	237	42	.	.	.
cord-306921-3afgpunj	238	1	Influenza	Influenza	NNP
cord-306921-3afgpunj	238	2	A	a	DT
cord-306921-3afgpunj	238	3	virus	virus	NN
cord-306921-3afgpunj	238	4	replication	replication	NN
cord-306921-3afgpunj	238	5	has	have	VBZ
cord-306921-3afgpunj	238	6	been	be	VBN
cord-306921-3afgpunj	238	7	shown	show	VBN
cord-306921-3afgpunj	238	8	to	to	TO
cord-306921-3afgpunj	238	9	interact	interact	VB
cord-306921-3afgpunj	238	10	with	with	IN
cord-306921-3afgpunj	238	11	cell	cell	NN
cord-306921-3afgpunj	238	12	division	division	NN
cord-306921-3afgpunj	238	13	factors	factor	NNS
cord-306921-3afgpunj	238	14	resulting	result	VBG
cord-306921-3afgpunj	238	15	to	to	IN
cord-306921-3afgpunj	238	16	arrest	arrest	VB
cord-306921-3afgpunj	238	17	of	of	IN
cord-306921-3afgpunj	238	18	the	the	DT
cord-306921-3afgpunj	238	19	cell	cell	NN
cord-306921-3afgpunj	238	20	cycle	cycle	NN
cord-306921-3afgpunj	238	21	division	division	NN
cord-306921-3afgpunj	238	22	at	at	IN
cord-306921-3afgpunj	238	23	the	the	DT
cord-306921-3afgpunj	238	24	G	g	NN
cord-306921-3afgpunj	238	25	0	0	CD
cord-306921-3afgpunj	238	26	/G	/g	SYM
cord-306921-3afgpunj	238	27	1	1	CD
cord-306921-3afgpunj	238	28	phase	phase	NN
cord-306921-3afgpunj	238	29	[	[	-LRB-
cord-306921-3afgpunj	238	30	142	142	CD
cord-306921-3afgpunj	238	31	]	]	-RRB-
cord-306921-3afgpunj	238	32	.	.	.
cord-306921-3afgpunj	239	1	Arrest	arrest	NN
cord-306921-3afgpunj	239	2	of	of	IN
cord-306921-3afgpunj	239	3	cell	cell	NN
cord-306921-3afgpunj	239	4	cycle	cycle	NN
cord-306921-3afgpunj	239	5	at	at	IN
cord-306921-3afgpunj	239	6	G	g	NN
cord-306921-3afgpunj	239	7	2	2	CD
cord-306921-3afgpunj	239	8	phase	phase	NN
cord-306921-3afgpunj	239	9	by	by	IN
cord-306921-3afgpunj	239	10	Human	Human	NNP
cord-306921-3afgpunj	239	11	Immunodeficiency	Immunodeficiency	NNP
cord-306921-3afgpunj	239	12	Virus-1	Virus-1	NNP
cord-306921-3afgpunj	239	13	(	(	-LRB-
cord-306921-3afgpunj	239	14	HIV-1	HIV-1	NNP
cord-306921-3afgpunj	239	15	)	)	-RRB-
cord-306921-3afgpunj	240	1	viral	viral	JJ
cord-306921-3afgpunj	240	2	protein	protein	NN
cord-306921-3afgpunj	240	3	R	r	NN
cord-306921-3afgpunj	240	4	(	(	-LRB-
cord-306921-3afgpunj	240	5	Vpr	Vpr	NNP
cord-306921-3afgpunj	240	6	)	)	-RRB-
cord-306921-3afgpunj	240	7	through	through	IN
cord-306921-3afgpunj	240	8	blocking	blocking	NN
cord-306921-3afgpunj	240	9	of	of	IN
cord-306921-3afgpunj	240	10	p34cdc2/	p34cdc2/	NN
cord-306921-3afgpunj	241	1	cyclin	cyclin	NNP
cord-306921-3afgpunj	241	2	B	B	NNP
cord-306921-3afgpunj	242	1	complex	complex	JJ
cord-306921-3afgpunj	242	2	stimulation	stimulation	NN
cord-306921-3afgpunj	242	3	[	[	-LRB-
cord-306921-3afgpunj	242	4	143	143	CD
cord-306921-3afgpunj	242	5	,	,	,
cord-306921-3afgpunj	242	6	144	144	CD
cord-306921-3afgpunj	242	7	]	]	-RRB-
cord-306921-3afgpunj	242	8	.	.	.
cord-306921-3afgpunj	243	1	Coronaviruses	coronaviruse	NNS
cord-306921-3afgpunj	243	2	;	;	:
cord-306921-3afgpunj	243	3	severe	severe	JJ
cord-306921-3afgpunj	243	4	acute	acute	JJ
cord-306921-3afgpunj	243	5	respiratory	respiratory	JJ
cord-306921-3afgpunj	243	6	syndrome	syndrome	NN
cord-306921-3afgpunj	243	7	and	and	CC
cord-306921-3afgpunj	243	8	mouse	mouse	NN
cord-306921-3afgpunj	243	9	hepatitis	hepatitis	NNP
cord-306921-3afgpunj	243	10	virus	virus	NN
cord-306921-3afgpunj	243	11	(	(	-LRB-
cord-306921-3afgpunj	243	12	MHV	MHV	NNP
cord-306921-3afgpunj	243	13	)	)	-RRB-
cord-306921-3afgpunj	243	14	are	be	VBP
cord-306921-3afgpunj	243	15	able	able	JJ
cord-306921-3afgpunj	243	16	to	to	TO
cord-306921-3afgpunj	243	17	capture	capture	VB
cord-306921-3afgpunj	243	18	cell	cell	NN
cord-306921-3afgpunj	243	19	cycle	cycle	NN
cord-306921-3afgpunj	243	20	at	at	IN
cord-306921-3afgpunj	243	21	G	g	NN
cord-306921-3afgpunj	243	22	0	0	CD
cord-306921-3afgpunj	243	23	/G	/g	SYM
cord-306921-3afgpunj	243	24	1	1	CD
cord-306921-3afgpunj	243	25	phase	phase	NN
cord-306921-3afgpunj	243	26	for	for	IN
cord-306921-3afgpunj	243	27	efficient	efficient	JJ
cord-306921-3afgpunj	243	28	genome	genome	NN
cord-306921-3afgpunj	243	29	replication	replication	NN
cord-306921-3afgpunj	243	30	[	[	-LRB-
cord-306921-3afgpunj	243	31	145	145	CD
cord-306921-3afgpunj	243	32	]	]	-RRB-
cord-306921-3afgpunj	243	33	[	[	-LRB-
cord-306921-3afgpunj	243	34	146	146	CD
cord-306921-3afgpunj	243	35	]	]	-RRB-
cord-306921-3afgpunj	243	36	[	[	-LRB-
cord-306921-3afgpunj	243	37	147	147	CD
cord-306921-3afgpunj	243	38	]	]	-RRB-
cord-306921-3afgpunj	243	39	.	.	.
cord-306921-3afgpunj	244	1	Among	among	IN
cord-306921-3afgpunj	244	2	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	244	3	,	,	,
cord-306921-3afgpunj	244	4	the	the	DT
cord-306921-3afgpunj	244	5	cell	cell	NN
cord-306921-3afgpunj	244	6	cycle	cycle	NN
cord-306921-3afgpunj	244	7	arrest	arrest	NN
cord-306921-3afgpunj	244	8	has	have	VBZ
cord-306921-3afgpunj	244	9	been	be	VBN
cord-306921-3afgpunj	244	10	reported	report	VBN
cord-306921-3afgpunj	244	11	for	for	IN
cord-306921-3afgpunj	244	12	EV	EV	NNP
cord-306921-3afgpunj	244	13	-	-	HYPH
cord-306921-3afgpunj	244	14	A71	A71	NNP
cord-306921-3afgpunj	244	15	,	,	,
cord-306921-3afgpunj	244	16	CV	CV	NNP
cord-306921-3afgpunj	244	17	-	-	HYPH
cord-306921-3afgpunj	244	18	A16	A16	NNP
cord-306921-3afgpunj	244	19	,	,	,
cord-306921-3afgpunj	244	20	EV	EV	NNP
cord-306921-3afgpunj	244	21	-	-	HYPH
cord-306921-3afgpunj	244	22	D68	D68	NNP
cord-306921-3afgpunj	244	23	and	and	CC
cord-306921-3afgpunj	244	24	recently	recently	RB
cord-306921-3afgpunj	244	25	for	for	IN
cord-306921-3afgpunj	244	26	CV	CV	NNP
cord-306921-3afgpunj	244	27	-	-	HYPH
cord-306921-3afgpunj	244	28	A6	A6	NNP
cord-306921-3afgpunj	244	29	viruses	virus	NNS
cord-306921-3afgpunj	244	30	.	.	.
cord-306921-3afgpunj	245	1	Targeting	target	VBG
cord-306921-3afgpunj	245	2	the	the	DT
cord-306921-3afgpunj	245	3	cell	cell	NN
cord-306921-3afgpunj	245	4	cycle	cycle	NN
cord-306921-3afgpunj	245	5	host	host	NN
cord-306921-3afgpunj	245	6	factors	factor	NNS
cord-306921-3afgpunj	245	7	helps	help	VBZ
cord-306921-3afgpunj	245	8	the	the	DT
cord-306921-3afgpunj	245	9	viruses	virus	NNS
cord-306921-3afgpunj	245	10	to	to	TO
cord-306921-3afgpunj	245	11	replicate	replicate	VB
cord-306921-3afgpunj	245	12	within	within	IN
cord-306921-3afgpunj	245	13	the	the	DT
cord-306921-3afgpunj	245	14	cells	cell	NNS
cord-306921-3afgpunj	245	15	with	with	IN
cord-306921-3afgpunj	245	16	limited	limited	JJ
cord-306921-3afgpunj	245	17	competition	competition	NN
cord-306921-3afgpunj	245	18	from	from	IN
cord-306921-3afgpunj	245	19	actively	actively	RB
cord-306921-3afgpunj	245	20	dividing	divide	VBG
cord-306921-3afgpunj	245	21	cells	cell	NNS
cord-306921-3afgpunj	245	22	.	.	.
cord-306921-3afgpunj	246	1	Completely	completely	RB
cord-306921-3afgpunj	246	2	understanding	understand	VBG
cord-306921-3afgpunj	246	3	the	the	DT
cord-306921-3afgpunj	246	4	how	how	WRB
cord-306921-3afgpunj	246	5	viruses	virus	NNS
cord-306921-3afgpunj	246	6	take	take	VBP
cord-306921-3afgpunj	246	7	advantage	advantage	NN
cord-306921-3afgpunj	246	8	of	of	IN
cord-306921-3afgpunj	246	9	the	the	DT
cord-306921-3afgpunj	246	10	cellular	cellular	JJ
cord-306921-3afgpunj	246	11	processes/	processes/	CD
cord-306921-3afgpunj	246	12	proteins	protein	NNS
cord-306921-3afgpunj	246	13	to	to	TO
cord-306921-3afgpunj	246	14	establish	establish	VB
cord-306921-3afgpunj	246	15	efficient	efficient	JJ
cord-306921-3afgpunj	246	16	infection	infection	NN
cord-306921-3afgpunj	246	17	and	and	CC
cord-306921-3afgpunj	246	18	genome	genome	NN
cord-306921-3afgpunj	246	19	replication	replication	NN
cord-306921-3afgpunj	246	20	is	be	VBZ
cord-306921-3afgpunj	246	21	vital	vital	JJ
cord-306921-3afgpunj	246	22	in	in	IN
cord-306921-3afgpunj	246	23	the	the	DT
cord-306921-3afgpunj	246	24	development	development	NN
cord-306921-3afgpunj	246	25	of	of	IN
cord-306921-3afgpunj	246	26	vaccines	vaccine	NNS
cord-306921-3afgpunj	246	27	and	and	CC
cord-306921-3afgpunj	246	28	antiviral	antiviral	JJ
cord-306921-3afgpunj	246	29	therapy	therapy	NN
cord-306921-3afgpunj	246	30	against	against	IN
cord-306921-3afgpunj	246	31	these	these	DT
cord-306921-3afgpunj	246	32	viruses	virus	NNS
cord-306921-3afgpunj	246	33	.	.	.
cord-306921-3afgpunj	247	1	Disruption	disruption	NN
cord-306921-3afgpunj	247	2	of	of	IN
cord-306921-3afgpunj	247	3	cell	cell	NN
cord-306921-3afgpunj	247	4	cycle	cycle	NN
cord-306921-3afgpunj	247	5	division	division	NN
cord-306921-3afgpunj	247	6	at	at	IN
cord-306921-3afgpunj	247	7	S	S	NNP
cord-306921-3afgpunj	247	8	phase	phase	NN
cord-306921-3afgpunj	247	9	has	have	VBZ
cord-306921-3afgpunj	247	10	been	be	VBN
cord-306921-3afgpunj	247	11	reported	report	VBN
cord-306921-3afgpunj	247	12	during	during	IN
cord-306921-3afgpunj	247	13	EV	EV	NNP
cord-306921-3afgpunj	247	14	-	-	HYPH
cord-306921-3afgpunj	247	15	A71	A71	NNP
cord-306921-3afgpunj	247	16	infection	infection	NN
cord-306921-3afgpunj	247	17	thereby	thereby	RB
cord-306921-3afgpunj	247	18	blocking	block	VBG
cord-306921-3afgpunj	247	19	the	the	DT
cord-306921-3afgpunj	247	20	entry	entry	NN
cord-306921-3afgpunj	247	21	of	of	IN
cord-306921-3afgpunj	247	22	the	the	DT
cord-306921-3afgpunj	247	23	cells	cell	NNS
cord-306921-3afgpunj	247	24	into	into	IN
cord-306921-3afgpunj	247	25	G2	G2	NNP
cord-306921-3afgpunj	247	26	/	/	SYM
cord-306921-3afgpunj	247	27	M	M	NNP
cord-306921-3afgpunj	247	28	phase	phase	NN
cord-306921-3afgpunj	247	29	through	through	IN
cord-306921-3afgpunj	247	30	viral	viral	JJ
cord-306921-3afgpunj	247	31	RNA	RNA	NNP
cord-306921-3afgpunj	247	32	dependent	dependent	JJ
cord-306921-3afgpunj	247	33	RNA	RNA	NNP
cord-306921-3afgpunj	247	34	polymerase	polymerase	NN
cord-306921-3afgpunj	247	35	3D	3D	NNP
cord-306921-3afgpunj	247	36	non	non	JJ
cord-306921-3afgpunj	247	37	-	-	JJ
cord-306921-3afgpunj	247	38	structural	structural	JJ
cord-306921-3afgpunj	247	39	protein	protein	NN
cord-306921-3afgpunj	247	40	[	[	-LRB-
cord-306921-3afgpunj	247	41	148	148	CD
cord-306921-3afgpunj	247	42	]	]	-RRB-
cord-306921-3afgpunj	247	43	.	.	.
cord-306921-3afgpunj	248	1	This	this	DT
cord-306921-3afgpunj	248	2	study	study	NN
cord-306921-3afgpunj	248	3	showed	show	VBD
cord-306921-3afgpunj	248	4	that	that	IN
cord-306921-3afgpunj	248	5	EV	EV	NNP
cord-306921-3afgpunj	248	6	-	-	HYPH
cord-306921-3afgpunj	248	7	A71	A71	NNP
cord-306921-3afgpunj	248	8	mediates	mediate	VBZ
cord-306921-3afgpunj	248	9	cell	cell	NN
cord-306921-3afgpunj	248	10	cycle	cycle	NN
cord-306921-3afgpunj	248	11	through	through	IN
cord-306921-3afgpunj	248	12	increasing	increase	VBG
cord-306921-3afgpunj	248	13	transcription	transcription	NN
cord-306921-3afgpunj	248	14	of	of	IN
cord-306921-3afgpunj	248	15	cyclin	cyclin	NN
cord-306921-3afgpunj	248	16	E1	e1	NN
cord-306921-3afgpunj	248	17	,	,	,
cord-306921-3afgpunj	248	18	promoting	promote	VBG
cord-306921-3afgpunj	248	19	proteasomal	proteasomal	JJ
cord-306921-3afgpunj	248	20	degradation	degradation	NN
cord-306921-3afgpunj	248	21	of	of	IN
cord-306921-3afgpunj	248	22	cyclin	cyclin	NNP
cord-306921-3afgpunj	248	23	A2	a2	NN
cord-306921-3afgpunj	248	24	and	and	CC
cord-306921-3afgpunj	248	25	eventual	eventual	JJ
cord-306921-3afgpunj	248	26	phosphorylation	phosphorylation	NN
cord-306921-3afgpunj	248	27	of	of	IN
cord-306921-3afgpunj	248	28	cyclin	cyclin	JJ
cord-306921-3afgpunj	248	29	dependent	dependent	JJ
cord-306921-3afgpunj	248	30	kinase	kinase	NN
cord-306921-3afgpunj	248	31	2(CDK2	2(cdk2	CD
cord-306921-3afgpunj	248	32	)	)	-RRB-
cord-306921-3afgpunj	248	33	thus	thus	RB
cord-306921-3afgpunj	248	34	regulating	regulate	VBG
cord-306921-3afgpunj	248	35	expression	expression	NN
cord-306921-3afgpunj	248	36	of	of	IN
cord-306921-3afgpunj	248	37	these	these	DT
cord-306921-3afgpunj	248	38	key	key	JJ
cord-306921-3afgpunj	248	39	cyclin	cyclin	NN
cord-306921-3afgpunj	248	40	regulators	regulator	NNS
cord-306921-3afgpunj	248	41	[	[	-LRB-
cord-306921-3afgpunj	248	42	148	148	CD
cord-306921-3afgpunj	248	43	]	]	-RRB-
cord-306921-3afgpunj	248	44	.	.	.
cord-306921-3afgpunj	249	1	The	the	DT
cord-306921-3afgpunj	249	2	same	same	JJ
cord-306921-3afgpunj	249	3	study	study	NN
cord-306921-3afgpunj	249	4	also	also	RB
cord-306921-3afgpunj	249	5	showed	show	VBD
cord-306921-3afgpunj	249	6	that	that	IN
cord-306921-3afgpunj	249	7	another	another	DT
cord-306921-3afgpunj	249	8	picornavirus	picornavirus	NN
cord-306921-3afgpunj	249	9	;	;	:
cord-306921-3afgpunj	249	10	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	249	11	A16	A16	NNP
cord-306921-3afgpunj	249	12	infection	infection	NN
cord-306921-3afgpunj	249	13	as	as	RB
cord-306921-3afgpunj	249	14	well	well	RB
cord-306921-3afgpunj	249	15	mediates	mediate	VBZ
cord-306921-3afgpunj	249	16	cell	cell	NN
cord-306921-3afgpunj	249	17	cycle	cycle	NN
cord-306921-3afgpunj	249	18	division	division	NN
cord-306921-3afgpunj	249	19	disruption	disruption	NN
cord-306921-3afgpunj	249	20	at	at	IN
cord-306921-3afgpunj	249	21	S	s	NN
cord-306921-3afgpunj	249	22	phase	phase	NN
cord-306921-3afgpunj	249	23	[	[	-LRB-
cord-306921-3afgpunj	249	24	148	148	CD
cord-306921-3afgpunj	249	25	]	]	-RRB-
cord-306921-3afgpunj	249	26	.	.	.
cord-306921-3afgpunj	250	1	Factors	factor	NNS
cord-306921-3afgpunj	250	2	that	that	WDT
cord-306921-3afgpunj	250	3	control	control	VBP
cord-306921-3afgpunj	250	4	cell	cell	NN
cord-306921-3afgpunj	250	5	cycle	cycle	NN
cord-306921-3afgpunj	250	6	and	and	CC
cord-306921-3afgpunj	250	7	differentiation	differentiation	NN
cord-306921-3afgpunj	250	8	;	;	:
cord-306921-3afgpunj	250	9	Aurora	Aurora	NNP
cord-306921-3afgpunj	250	10	B	B	NNP
cord-306921-3afgpunj	250	11	kinase	kinase	NN
cord-306921-3afgpunj	250	12	(	(	-LRB-
cord-306921-3afgpunj	250	13	AURKB	AURKB	NNP
cord-306921-3afgpunj	250	14	)	)	-RRB-
cord-306921-3afgpunj	250	15	and	and	CC
cord-306921-3afgpunj	250	16	cyclin	cyclin	NN
cord-306921-3afgpunj	250	17	dependent	dependent	JJ
cord-306921-3afgpunj	251	1	kinase	kinase	NNP
cord-306921-3afgpunj	251	2	6	6	CD
cord-306921-3afgpunj	251	3	(	(	-LRB-
cord-306921-3afgpunj	251	4	CDK6	CDK6	NNP
cord-306921-3afgpunj	251	5	)	)	-RRB-
cord-306921-3afgpunj	251	6	were	be	VBD
cord-306921-3afgpunj	251	7	identified	identify	VBN
cord-306921-3afgpunj	251	8	by	by	IN
cord-306921-3afgpunj	251	9	Wu	Wu	NNP
cord-306921-3afgpunj	251	10	and	and	CC
cord-306921-3afgpunj	251	11	colleagues	colleague	NNS
cord-306921-3afgpunj	251	12	as	as	IN
cord-306921-3afgpunj	251	13	EV	EV	NNP
cord-306921-3afgpunj	251	14	-	-	HYPH
cord-306921-3afgpunj	251	15	A71	A71	NNP
cord-306921-3afgpunj	251	16	restriction	restriction	NN
cord-306921-3afgpunj	251	17	factors	factor	NNS
cord-306921-3afgpunj	251	18	[	[	-LRB-
cord-306921-3afgpunj	251	19	82	82	CD
cord-306921-3afgpunj	251	20	]	]	-RRB-
cord-306921-3afgpunj	251	21	.	.	.
cord-306921-3afgpunj	252	1	EV	EV	NNP
cord-306921-3afgpunj	252	2	-	-	HYPH
cord-306921-3afgpunj	252	3	D68	D68	NNP
cord-306921-3afgpunj	252	4	mediates	mediate	VBZ
cord-306921-3afgpunj	252	5	synchronization	synchronization	NN
cord-306921-3afgpunj	252	6	of	of	IN
cord-306921-3afgpunj	252	7	cell	cell	NN
cord-306921-3afgpunj	252	8	division	division	NN
cord-306921-3afgpunj	252	9	at	at	IN
cord-306921-3afgpunj	252	10	the	the	DT
cord-306921-3afgpunj	252	11	G	g	NN
cord-306921-3afgpunj	252	12	0	0	CD
cord-306921-3afgpunj	252	13	/G	/g	SYM
cord-306921-3afgpunj	252	14	1	1	CD
cord-306921-3afgpunj	252	15	but	but	CC
cord-306921-3afgpunj	252	16	not	not	RB
cord-306921-3afgpunj	252	17	at	at	IN
cord-306921-3afgpunj	252	18	S	s	NN
cord-306921-3afgpunj	252	19	phase	phase	NN
cord-306921-3afgpunj	252	20	thus	thus	RB
cord-306921-3afgpunj	252	21	promoting	promote	VBG
cord-306921-3afgpunj	252	22	viral	viral	JJ
cord-306921-3afgpunj	252	23	replication	replication	NN
cord-306921-3afgpunj	252	24	while	while	IN
cord-306921-3afgpunj	252	25	cell	cell	NN
cord-306921-3afgpunj	252	26	cycle	cycle	NN
cord-306921-3afgpunj	252	27	arrest	arrest	NN
cord-306921-3afgpunj	252	28	at	at	IN
cord-306921-3afgpunj	252	29	G2	G2	NNP
cord-306921-3afgpunj	252	30	/	/	SYM
cord-306921-3afgpunj	252	31	M	M	NNP
cord-306921-3afgpunj	252	32	phase	phase	NN
cord-306921-3afgpunj	252	33	inhibited	inhibit	VBN
cord-306921-3afgpunj	252	34	viral	viral	JJ
cord-306921-3afgpunj	252	35	replication	replication	NN
cord-306921-3afgpunj	252	36	[	[	-LRB-
cord-306921-3afgpunj	252	37	149	149	CD
cord-306921-3afgpunj	252	38	]	]	-RRB-
cord-306921-3afgpunj	252	39	.	.	.
cord-306921-3afgpunj	253	1	This	this	DT
cord-306921-3afgpunj	253	2	observation	observation	NN
cord-306921-3afgpunj	253	3	is	be	VBZ
cord-306921-3afgpunj	253	4	contrary	contrary	JJ
cord-306921-3afgpunj	253	5	to	to	IN
cord-306921-3afgpunj	253	6	CV	CV	NNP
cord-306921-3afgpunj	253	7	-	-	HYPH
cord-306921-3afgpunj	253	8	A16	A16	NNP
cord-306921-3afgpunj	253	9	and	and	CC
cord-306921-3afgpunj	253	10	EV	EV	NNP
cord-306921-3afgpunj	253	11	-	-	HYPH
cord-306921-3afgpunj	253	12	A71	A71	NNP
cord-306921-3afgpunj	253	13	where	where	WRB
cord-306921-3afgpunj	253	14	cell	cell	NN
cord-306921-3afgpunj	253	15	arrest	arrest	NN
cord-306921-3afgpunj	253	16	at	at	IN
cord-306921-3afgpunj	253	17	S	s	NN
cord-306921-3afgpunj	253	18	phase	phase	NN
cord-306921-3afgpunj	253	19	promoted	promote	VBD
cord-306921-3afgpunj	253	20	viral	viral	JJ
cord-306921-3afgpunj	253	21	replication	replication	NN
cord-306921-3afgpunj	253	22	.	.	.
cord-306921-3afgpunj	254	1	Remarkably	remarkably	RB
cord-306921-3afgpunj	254	2	,	,	,
cord-306921-3afgpunj	254	3	cell	cell	NN
cord-306921-3afgpunj	254	4	cycle	cycle	NN
cord-306921-3afgpunj	254	5	disruption	disruption	NN
cord-306921-3afgpunj	254	6	at	at	IN
cord-306921-3afgpunj	254	7	G2	G2	NNP
cord-306921-3afgpunj	254	8	/	/	SYM
cord-306921-3afgpunj	254	9	M	M	NNP
cord-306921-3afgpunj	254	10	phase	phase	NN
cord-306921-3afgpunj	254	11	inhibited	inhibit	VBN
cord-306921-3afgpunj	254	12	viral	viral	JJ
cord-306921-3afgpunj	254	13	replication	replication	NN
cord-306921-3afgpunj	254	14	for	for	IN
cord-306921-3afgpunj	254	15	CV	cv	NN
cord-306921-3afgpunj	254	16	-	-	HYPH
cord-306921-3afgpunj	254	17	A16	A16	NNP
cord-306921-3afgpunj	254	18	,	,	,
cord-306921-3afgpunj	254	19	EV	EV	NNP
cord-306921-3afgpunj	254	20	-	-	HYPH
cord-306921-3afgpunj	254	21	A71	A71	NNP
cord-306921-3afgpunj	254	22	and	and	CC
cord-306921-3afgpunj	254	23	EV	EV	NNP
cord-306921-3afgpunj	254	24	-	-	HYPH
cord-306921-3afgpunj	254	25	D68	D68	NNP
cord-306921-3afgpunj	254	26	viruses	virus	NNS
cord-306921-3afgpunj	254	27	[	[	-LRB-
cord-306921-3afgpunj	254	28	148	148	CD
cord-306921-3afgpunj	254	29	,	,	,
cord-306921-3afgpunj	254	30	149	149	CD
cord-306921-3afgpunj	254	31	]	]	-RRB-
cord-306921-3afgpunj	254	32	.	.	.
cord-306921-3afgpunj	255	1	Wang	Wang	NNP
cord-306921-3afgpunj	255	2	and	and	CC
cord-306921-3afgpunj	255	3	colleagues	colleague	NNS
cord-306921-3afgpunj	255	4	demonstrated	demonstrate	VBD
cord-306921-3afgpunj	255	5	for	for	IN
cord-306921-3afgpunj	255	6	the	the	DT
cord-306921-3afgpunj	255	7	first	first	JJ
cord-306921-3afgpunj	255	8	time	time	NN
cord-306921-3afgpunj	255	9	that	that	IN
cord-306921-3afgpunj	255	10	CV	CV	NNP
cord-306921-3afgpunj	255	11	-	-	HYPH
cord-306921-3afgpunj	255	12	A6	A6	NNP
cord-306921-3afgpunj	255	13	disrupts	disrupt	VBZ
cord-306921-3afgpunj	255	14	cell	cell	NN
cord-306921-3afgpunj	255	15	division	division	NN
cord-306921-3afgpunj	255	16	cycle	cycle	NN
cord-306921-3afgpunj	255	17	at	at	IN
cord-306921-3afgpunj	255	18	G0	G0	NNP
cord-306921-3afgpunj	255	19	/	/	SYM
cord-306921-3afgpunj	255	20	G1	G1	NNP
cord-306921-3afgpunj	255	21	phase	phase	NN
cord-306921-3afgpunj	255	22	for	for	IN
cord-306921-3afgpunj	255	23	viral	viral	JJ
cord-306921-3afgpunj	255	24	replication	replication	NN
cord-306921-3afgpunj	255	25	through	through	IN
cord-306921-3afgpunj	255	26	its	-PRON-	PRP$
cord-306921-3afgpunj	255	27	nonstructural	nonstructural	JJ
cord-306921-3afgpunj	255	28	protein	protein	NN
cord-306921-3afgpunj	255	29	RNA	RNA	NNP
cord-306921-3afgpunj	255	30	-	-	HYPH
cord-306921-3afgpunj	255	31	dependent	dependent	JJ
cord-306921-3afgpunj	255	32	RNA	RNA	NNP
cord-306921-3afgpunj	255	33	polymerase	polymerase	NN
cord-306921-3afgpunj	255	34	3D	3D	NNP
cord-306921-3afgpunj	255	35	and	and	CC
cord-306921-3afgpunj	255	36	3C	3C	NNP
cord-306921-3afgpunj	255	37	protease	protease	NN
cord-306921-3afgpunj	255	38	proteins	protein	NNS
cord-306921-3afgpunj	255	39	[	[	-LRB-
cord-306921-3afgpunj	255	40	150	150	CD
cord-306921-3afgpunj	255	41	]	]	-RRB-
cord-306921-3afgpunj	255	42	.	.	.
cord-306921-3afgpunj	256	1	Viruses	virus	NNS
cord-306921-3afgpunj	256	2	depends	depend	VBZ
cord-306921-3afgpunj	256	3	on	on	IN
cord-306921-3afgpunj	256	4	host	host	NN
cord-306921-3afgpunj	256	5	cell	cell	NN
cord-306921-3afgpunj	256	6	proteins	protein	NNS
cord-306921-3afgpunj	256	7	and	and	CC
cord-306921-3afgpunj	256	8	processes	process	NNS
cord-306921-3afgpunj	256	9	for	for	IN
cord-306921-3afgpunj	256	10	efficient	efficient	JJ
cord-306921-3afgpunj	256	11	genome	genome	NN
cord-306921-3afgpunj	256	12	replication	replication	NN
cord-306921-3afgpunj	256	13	.	.	.
cord-306921-3afgpunj	257	1	Exploiting	exploit	VBG
cord-306921-3afgpunj	257	2	the	the	DT
cord-306921-3afgpunj	257	3	cell	cell	NN
cord-306921-3afgpunj	257	4	cycle	cycle	NN
cord-306921-3afgpunj	257	5	process	process	NN
cord-306921-3afgpunj	257	6	,	,	,
cord-306921-3afgpunj	257	7	a	a	DT
cord-306921-3afgpunj	257	8	highly	highly	RB
cord-306921-3afgpunj	257	9	regulated	regulate	VBN
cord-306921-3afgpunj	257	10	process	process	NN
cord-306921-3afgpunj	257	11	enables	enable	VBZ
cord-306921-3afgpunj	257	12	viruses	virus	NNS
cord-306921-3afgpunj	257	13	to	to	TO
cord-306921-3afgpunj	257	14	have	have	VB
cord-306921-3afgpunj	257	15	unfettered	unfettered	JJ
cord-306921-3afgpunj	257	16	access	access	NN
cord-306921-3afgpunj	257	17	to	to	IN
cord-306921-3afgpunj	257	18	the	the	DT
cord-306921-3afgpunj	257	19	cell	cell	NN
cord-306921-3afgpunj	257	20	cycle	cycle	NN
cord-306921-3afgpunj	257	21	factors	factor	NNS
cord-306921-3afgpunj	257	22	for	for	IN
cord-306921-3afgpunj	257	23	efficient	efficient	JJ
cord-306921-3afgpunj	257	24	viral	viral	JJ
cord-306921-3afgpunj	257	25	replication	replication	NN
cord-306921-3afgpunj	257	26	.	.	.
cord-306921-3afgpunj	258	1	Future	future	JJ
cord-306921-3afgpunj	258	2	work	work	NN
cord-306921-3afgpunj	258	3	should	should	MD
cord-306921-3afgpunj	258	4	look	look	VB
cord-306921-3afgpunj	258	5	at	at	IN
cord-306921-3afgpunj	258	6	the	the	DT
cord-306921-3afgpunj	258	7	cell	cell	NN
cord-306921-3afgpunj	258	8	cycle	cycle	NN
cord-306921-3afgpunj	258	9	stage	stage	NN
cord-306921-3afgpunj	258	10	where	where	WRB
cord-306921-3afgpunj	258	11	other	other	JJ
cord-306921-3afgpunj	258	12	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	258	13	disrupt	disrupt	VBP
cord-306921-3afgpunj	258	14	cell	cell	NN
cord-306921-3afgpunj	258	15	division	division	NN
cord-306921-3afgpunj	258	16	cycle	cycle	NN
cord-306921-3afgpunj	258	17	.	.	.
cord-306921-3afgpunj	259	1	This	this	DT
cord-306921-3afgpunj	259	2	will	will	MD
cord-306921-3afgpunj	259	3	enable	enable	VB
cord-306921-3afgpunj	259	4	better	well	JJR
cord-306921-3afgpunj	259	5	antiviral	antiviral	JJ
cord-306921-3afgpunj	259	6	therapy	therapy	NN
cord-306921-3afgpunj	259	7	design	design	NN
cord-306921-3afgpunj	259	8	and	and	CC
cord-306921-3afgpunj	259	9	development	development	NN
cord-306921-3afgpunj	259	10	targeting	target	VBG
cord-306921-3afgpunj	259	11	different	different	JJ
cord-306921-3afgpunj	259	12	viruses	virus	NNS
cord-306921-3afgpunj	259	13	associated	associate	VBN
cord-306921-3afgpunj	259	14	with	with	IN
cord-306921-3afgpunj	259	15	HFMD	HFMD	NNP
cord-306921-3afgpunj	259	16	as	as	RB
cord-306921-3afgpunj	259	17	well	well	RB
cord-306921-3afgpunj	259	18	as	as	IN
cord-306921-3afgpunj	259	19	other	other	JJ
cord-306921-3afgpunj	259	20	forms	form	NNS
cord-306921-3afgpunj	259	21	of	of	IN
cord-306921-3afgpunj	259	22	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	259	23	infections	infection	NNS
cord-306921-3afgpunj	259	24	.	.	.
cord-306921-3afgpunj	260	1	The	the	DT
cord-306921-3afgpunj	260	2	process	process	NN
cord-306921-3afgpunj	260	3	of	of	IN
cord-306921-3afgpunj	260	4	autophagy	autophagy	NN
cord-306921-3afgpunj	260	5	has	have	VBZ
cord-306921-3afgpunj	260	6	been	be	VBN
cord-306921-3afgpunj	260	7	linked	link	VBN
cord-306921-3afgpunj	260	8	to	to	IN
cord-306921-3afgpunj	260	9	the	the	DT
cord-306921-3afgpunj	260	10	formation	formation	NN
cord-306921-3afgpunj	260	11	of	of	IN
cord-306921-3afgpunj	260	12	the	the	DT
cord-306921-3afgpunj	260	13	double	double	JJ
cord-306921-3afgpunj	260	14	membranous	membranous	JJ
cord-306921-3afgpunj	260	15	structures	structure	NNS
cord-306921-3afgpunj	260	16	which	which	WDT
cord-306921-3afgpunj	260	17	acts	act	VBZ
cord-306921-3afgpunj	260	18	a	a	DT
cord-306921-3afgpunj	260	19	replication	replication	NN
cord-306921-3afgpunj	260	20	site	site	NN
cord-306921-3afgpunj	260	21	for	for	IN
cord-306921-3afgpunj	260	22	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	260	23	including	include	VBG
cord-306921-3afgpunj	260	24	poliovirus	poliovirus	NN
cord-306921-3afgpunj	260	25	(	(	-LRB-
cord-306921-3afgpunj	260	26	PV	PV	NNP
cord-306921-3afgpunj	260	27	)	)	-RRB-
cord-306921-3afgpunj	260	28	.	.	.
cord-306921-3afgpunj	261	1	The	the	DT
cord-306921-3afgpunj	261	2	formation	formation	NN
cord-306921-3afgpunj	261	3	of	of	IN
cord-306921-3afgpunj	261	4	these	these	DT
cord-306921-3afgpunj	261	5	membranous	membranous	JJ
cord-306921-3afgpunj	261	6	structures	structure	NNS
cord-306921-3afgpunj	261	7	is	be	VBZ
cord-306921-3afgpunj	261	8	dependent	dependent	JJ
cord-306921-3afgpunj	261	9	on	on	IN
cord-306921-3afgpunj	261	10	the	the	DT
cord-306921-3afgpunj	261	11	exploitation	exploitation	NN
cord-306921-3afgpunj	261	12	of	of	IN
cord-306921-3afgpunj	261	13	the	the	DT
cord-306921-3afgpunj	261	14	autophagy	autophagy	NN
cord-306921-3afgpunj	261	15	process	process	NN
cord-306921-3afgpunj	261	16	by	by	IN
cord-306921-3afgpunj	261	17	the	the	DT
cord-306921-3afgpunj	261	18	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	261	19	(	(	-LRB-
cord-306921-3afgpunj	261	20	PV	PV	NNP
cord-306921-3afgpunj	261	21	,	,	,
cord-306921-3afgpunj	261	22	CV	CV	NNP
cord-306921-3afgpunj	261	23	-	-	HYPH
cord-306921-3afgpunj	261	24	B	B	NNP
cord-306921-3afgpunj	261	25	,	,	,
cord-306921-3afgpunj	261	26	CV	cv	NN
cord-306921-3afgpunj	261	27	-	-	HYPH
cord-306921-3afgpunj	261	28	B3	B3	NNP
cord-306921-3afgpunj	261	29	among	among	IN
cord-306921-3afgpunj	261	30	other	other	JJ
cord-306921-3afgpunj	261	31	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	261	32	)	)	-RRB-
cord-306921-3afgpunj	261	33	where	where	WRB
cord-306921-3afgpunj	261	34	3A	3A	NNP
cord-306921-3afgpunj	261	35	and	and	CC
cord-306921-3afgpunj	261	36	2	2	CD
cord-306921-3afgpunj	261	37	BC	BC	NNP
cord-306921-3afgpunj	261	38	viral	viral	JJ
cord-306921-3afgpunj	261	39	proteins	protein	NNS
cord-306921-3afgpunj	261	40	are	be	VBP
cord-306921-3afgpunj	261	41	involved	involve	VBN
cord-306921-3afgpunj	261	42	[	[	-LRB-
cord-306921-3afgpunj	261	43	151	151	CD
cord-306921-3afgpunj	261	44	]	]	-RRB-
cord-306921-3afgpunj	261	45	[	[	-LRB-
cord-306921-3afgpunj	261	46	152	152	CD
cord-306921-3afgpunj	261	47	]	]	-RRB-
cord-306921-3afgpunj	261	48	[	[	-LRB-
cord-306921-3afgpunj	261	49	153	153	CD
cord-306921-3afgpunj	261	50	]	]	-RRB-
cord-306921-3afgpunj	261	51	[	[	-LRB-
cord-306921-3afgpunj	261	52	154	154	CD
cord-306921-3afgpunj	261	53	]	]	-RRB-
cord-306921-3afgpunj	261	54	[	[	-LRB-
cord-306921-3afgpunj	261	55	155	155	CD
cord-306921-3afgpunj	261	56	]	]	-RRB-
cord-306921-3afgpunj	261	57	[	[	-LRB-
cord-306921-3afgpunj	261	58	156	156	CD
cord-306921-3afgpunj	261	59	]	]	-RRB-
cord-306921-3afgpunj	261	60	.	.	.
cord-306921-3afgpunj	262	1	Recent	recent	JJ
cord-306921-3afgpunj	262	2	studies	study	NNS
cord-306921-3afgpunj	262	3	have	have	VBP
cord-306921-3afgpunj	262	4	linked	link	VBN
cord-306921-3afgpunj	262	5	autophagy	autophagy	NN
cord-306921-3afgpunj	262	6	regulators	regulator	NNS
cord-306921-3afgpunj	262	7	to	to	IN
cord-306921-3afgpunj	262	8	the	the	DT
cord-306921-3afgpunj	262	9	formation	formation	NN
cord-306921-3afgpunj	262	10	of	of	IN
cord-306921-3afgpunj	262	11	the	the	DT
cord-306921-3afgpunj	262	12	autophagosome/	autophagosome/	NNS
cord-306921-3afgpunj	263	1	the	the	DT
cord-306921-3afgpunj	263	2	replication	replication	NN
cord-306921-3afgpunj	263	3	organelle	organelle	NN
cord-306921-3afgpunj	263	4	during	during	IN
cord-306921-3afgpunj	263	5	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	263	6	B	B	NNP
cord-306921-3afgpunj	263	7	(	(	-LRB-
cord-306921-3afgpunj	263	8	CV	cv	NN
cord-306921-3afgpunj	263	9	-	-	HYPH
cord-306921-3afgpunj	263	10	B	B	NNP
cord-306921-3afgpunj	263	11	)	)	-RRB-
cord-306921-3afgpunj	263	12	;	;	:
cord-306921-3afgpunj	263	13	thus	thus	RB
cord-306921-3afgpunj	263	14	showing	show	VBG
cord-306921-3afgpunj	263	15	that	that	IN
cord-306921-3afgpunj	263	16	enteroviruses	enteroviruse	VBZ
cord-306921-3afgpunj	263	17	not	not	RB
cord-306921-3afgpunj	263	18	only	only	RB
cord-306921-3afgpunj	263	19	target	target	VB
cord-306921-3afgpunj	263	20	the	the	DT
cord-306921-3afgpunj	263	21	autophagy	autophagy	NN
cord-306921-3afgpunj	263	22	process	process	NN
cord-306921-3afgpunj	263	23	but	but	CC
cord-306921-3afgpunj	263	24	also	also	RB
cord-306921-3afgpunj	263	25	its	-PRON-	PRP$
cord-306921-3afgpunj	263	26	regulators	regulator	NNS
cord-306921-3afgpunj	263	27	for	for	IN
cord-306921-3afgpunj	263	28	efficient	efficient	JJ
cord-306921-3afgpunj	263	29	replication	replication	NN
cord-306921-3afgpunj	263	30	of	of	IN
cord-306921-3afgpunj	263	31	their	-PRON-	PRP$
cord-306921-3afgpunj	263	32	genomes	genome	NNS
cord-306921-3afgpunj	263	33	[	[	-LRB-
cord-306921-3afgpunj	263	34	157	157	CD
cord-306921-3afgpunj	263	35	,	,	,
cord-306921-3afgpunj	263	36	158	158	CD
cord-306921-3afgpunj	263	37	]	]	-RRB-
cord-306921-3afgpunj	263	38	.	.	.
cord-306921-3afgpunj	264	1	Wong	Wong	NNP
cord-306921-3afgpunj	264	2	and	and	CC
cord-306921-3afgpunj	264	3	colleagues	colleague	NNS
cord-306921-3afgpunj	264	4	showed	show	VBD
cord-306921-3afgpunj	264	5	that	that	IN
cord-306921-3afgpunj	264	6	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	264	7	B3	B3	NNP
cord-306921-3afgpunj	264	8	(	(	-LRB-
cord-306921-3afgpunj	264	9	CV	cv	NN
cord-306921-3afgpunj	264	10	-	-	HYPH
cord-306921-3afgpunj	264	11	B3	B3	NNP
cord-306921-3afgpunj	264	12	)	)	-RRB-
cord-306921-3afgpunj	264	13	induces	induce	VBZ
cord-306921-3afgpunj	264	14	autophagosome	autophagosome	JJ
cord-306921-3afgpunj	264	15	formation	formation	NN
cord-306921-3afgpunj	264	16	without	without	IN
cord-306921-3afgpunj	264	17	lysosome	lysosome	NN
cord-306921-3afgpunj	264	18	degradation	degradation	NN
cord-306921-3afgpunj	264	19	of	of	IN
cord-306921-3afgpunj	264	20	proteins	protein	NNS
cord-306921-3afgpunj	264	21	[	[	-LRB-
cord-306921-3afgpunj	264	22	156	156	CD
cord-306921-3afgpunj	264	23	]	]	-RRB-
cord-306921-3afgpunj	264	24	,	,	,
cord-306921-3afgpunj	264	25	clearly	clearly	RB
cord-306921-3afgpunj	264	26	highlighting	highlight	VBG
cord-306921-3afgpunj	264	27	the	the	DT
cord-306921-3afgpunj	264	28	role	role	NN
cord-306921-3afgpunj	264	29	of	of	IN
cord-306921-3afgpunj	264	30	autophagosome	autophagosome	NNP
cord-306921-3afgpunj	264	31	in	in	IN
cord-306921-3afgpunj	264	32	the	the	DT
cord-306921-3afgpunj	264	33	formation	formation	NN
cord-306921-3afgpunj	264	34	of	of	IN
cord-306921-3afgpunj	264	35	the	the	DT
cord-306921-3afgpunj	264	36	replication	replication	NN
cord-306921-3afgpunj	264	37	organelles	organelle	NNS
cord-306921-3afgpunj	264	38	during	during	IN
cord-306921-3afgpunj	264	39	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	264	40	infections	infection	NNS
cord-306921-3afgpunj	264	41	.	.	.
cord-306921-3afgpunj	265	1	Follow	follow	VB
cord-306921-3afgpunj	265	2	-	-	HYPH
cord-306921-3afgpunj	265	3	up	up	NN
cord-306921-3afgpunj	265	4	studies	study	NNS
cord-306921-3afgpunj	265	5	by	by	IN
cord-306921-3afgpunj	265	6	Zhai	Zhai	NNP
cord-306921-3afgpunj	265	7	and	and	CC
cord-306921-3afgpunj	265	8	colleagues	colleague	NNS
cord-306921-3afgpunj	265	9	observed	observe	VBD
cord-306921-3afgpunj	265	10	formation	formation	NN
cord-306921-3afgpunj	265	11	of	of	IN
cord-306921-3afgpunj	265	12	autophagosomes	autophagosomes	NNP
cord-306921-3afgpunj	265	13	both	both	CC
cord-306921-3afgpunj	265	14	in	in	IN
cord-306921-3afgpunj	265	15	CV	CV	NNP
cord-306921-3afgpunj	265	16	-	-	HYPH
cord-306921-3afgpunj	265	17	B3	b3	NN
cord-306921-3afgpunj	265	18	infected	infected	JJ
cord-306921-3afgpunj	265	19	fibroblasts	fibroblast	NNS
cord-306921-3afgpunj	265	20	and	and	CC
cord-306921-3afgpunj	265	21	in	in	IN
cord-306921-3afgpunj	265	22	Balb	Balb	NNP
cord-306921-3afgpunj	265	23	/	/	SYM
cord-306921-3afgpunj	265	24	c	c	NN
cord-306921-3afgpunj	265	25	mice	mouse	NNS
cord-306921-3afgpunj	265	26	thus	thus	RB
cord-306921-3afgpunj	265	27	,	,	,
cord-306921-3afgpunj	265	28	linking	link	VBG
cord-306921-3afgpunj	265	29	autophagy	autophagy	NN
cord-306921-3afgpunj	265	30	to	to	IN
cord-306921-3afgpunj	265	31	the	the	DT
cord-306921-3afgpunj	265	32	pathogenesis	pathogenesis	NN
cord-306921-3afgpunj	265	33	of	of	IN
cord-306921-3afgpunj	265	34	myocarditis	myocarditis	NN
cord-306921-3afgpunj	265	35	infections	infection	NNS
cord-306921-3afgpunj	265	36	[	[	-LRB-
cord-306921-3afgpunj	265	37	159	159	CD
cord-306921-3afgpunj	265	38	]	]	-RRB-
cord-306921-3afgpunj	265	39	.	.	.
cord-306921-3afgpunj	266	1	The	the	DT
cord-306921-3afgpunj	266	2	shedding	shedding	NN
cord-306921-3afgpunj	266	3	of	of	IN
cord-306921-3afgpunj	266	4	CV	cv	NN
cord-306921-3afgpunj	266	5	-	-	HYPH
cord-306921-3afgpunj	266	6	B3	B3	NNP
cord-306921-3afgpunj	266	7	virus	virus	NN
cord-306921-3afgpunj	266	8	from	from	IN
cord-306921-3afgpunj	266	9	infected	infected	JJ
cord-306921-3afgpunj	266	10	cells	cell	NNS
cord-306921-3afgpunj	266	11	was	be	VBD
cord-306921-3afgpunj	266	12	linked	link	VBN
cord-306921-3afgpunj	266	13	by	by	IN
cord-306921-3afgpunj	266	14	Robinson	Robinson	NNP
cord-306921-3afgpunj	266	15	and	and	CC
cord-306921-3afgpunj	266	16	colleagues	colleague	NNS
cord-306921-3afgpunj	266	17	to	to	IN
cord-306921-3afgpunj	266	18	the	the	DT
cord-306921-3afgpunj	266	19	extracellular	extracellular	JJ
cord-306921-3afgpunj	266	20	microvesicles	microvesicle	NNS
cord-306921-3afgpunj	266	21	with	with	IN
cord-306921-3afgpunj	266	22	autophagosome	autophagosome	JJ
cord-306921-3afgpunj	266	23	markers	marker	NNS
cord-306921-3afgpunj	266	24	.	.	.
cord-306921-3afgpunj	267	1	The	the	DT
cord-306921-3afgpunj	267	2	role	role	NN
cord-306921-3afgpunj	267	3	of	of	IN
cord-306921-3afgpunj	267	4	the	the	DT
cord-306921-3afgpunj	267	5	autophagomes	autophagome	NNS
cord-306921-3afgpunj	267	6	in	in	IN
cord-306921-3afgpunj	267	7	the	the	DT
cord-306921-3afgpunj	267	8	release	release	NN
cord-306921-3afgpunj	267	9	of	of	IN
cord-306921-3afgpunj	267	10	CV	cv	NN
cord-306921-3afgpunj	267	11	-	-	HYPH
cord-306921-3afgpunj	267	12	B3	B3	NNP
cord-306921-3afgpunj	267	13	virus	virus	NN
cord-306921-3afgpunj	267	14	from	from	IN
cord-306921-3afgpunj	267	15	infected	infected	JJ
cord-306921-3afgpunj	267	16	cells	cell	NNS
cord-306921-3afgpunj	267	17	was	be	VBD
cord-306921-3afgpunj	267	18	later	later	RB
cord-306921-3afgpunj	267	19	validated	validate	VBN
cord-306921-3afgpunj	267	20	by	by	IN
cord-306921-3afgpunj	267	21	Sin	sin	NN
cord-306921-3afgpunj	267	22	and	and	CC
cord-306921-3afgpunj	267	23	coworkers	coworker	NNS
cord-306921-3afgpunj	267	24	[	[	-LRB-
cord-306921-3afgpunj	267	25	160	160	CD
cord-306921-3afgpunj	267	26	]	]	-RRB-
cord-306921-3afgpunj	267	27	.	.	.
cord-306921-3afgpunj	268	1	The	the	DT
cord-306921-3afgpunj	268	2	study	study	NN
cord-306921-3afgpunj	268	3	by	by	IN
cord-306921-3afgpunj	268	4	Sin	sin	NN
cord-306921-3afgpunj	268	5	and	and	CC
cord-306921-3afgpunj	268	6	colleagues	colleague	NNS
cord-306921-3afgpunj	268	7	demonstrated	demonstrate	VBD
cord-306921-3afgpunj	268	8	ability	ability	NN
cord-306921-3afgpunj	268	9	of	of	IN
cord-306921-3afgpunj	268	10	CV	cv	NN
cord-306921-3afgpunj	268	11	-	-	HYPH
cord-306921-3afgpunj	268	12	B3	b3	NN
cord-306921-3afgpunj	268	13	to	to	IN
cord-306921-3afgpunj	268	14	egress	egress	NN
cord-306921-3afgpunj	268	15	from	from	IN
cord-306921-3afgpunj	268	16	cells	cell	NNS
cord-306921-3afgpunj	268	17	and	and	CC
cord-306921-3afgpunj	268	18	infect	infect	VBP
cord-306921-3afgpunj	268	19	other	other	JJ
cord-306921-3afgpunj	268	20	cells	cell	NNS
cord-306921-3afgpunj	268	21	via	via	IN
cord-306921-3afgpunj	268	22	a	a	DT
cord-306921-3afgpunj	268	23	dynamin	dynamin	NN
cord-306921-3afgpunj	268	24	related	relate	VBN
cord-306921-3afgpunj	268	25	protein	protein	NN
cord-306921-3afgpunj	268	26	1(DRP1	1(drp1	CD
cord-306921-3afgpunj	268	27	)	)	-RRB-
cord-306921-3afgpunj	268	28	initiated	initiate	VBN
cord-306921-3afgpunj	268	29	mitochondrial	mitochondrial	JJ
cord-306921-3afgpunj	268	30	fragmentation	fragmentation	NN
cord-306921-3afgpunj	268	31	;	;	:
cord-306921-3afgpunj	268	32	a	a	DT
cord-306921-3afgpunj	268	33	process	process	NN
cord-306921-3afgpunj	268	34	vital	vital	JJ
cord-306921-3afgpunj	268	35	for	for	IN
cord-306921-3afgpunj	268	36	the	the	DT
cord-306921-3afgpunj	268	37	mitochondrial	mitochondrial	NN
cord-306921-3afgpunj	268	38	based	base	VBN
cord-306921-3afgpunj	268	39	autophagy	autophagy	NN
cord-306921-3afgpunj	268	40	elimination	elimination	NN
cord-306921-3afgpunj	268	41	/	/	SYM
cord-306921-3afgpunj	268	42	mitophagy	mitophagy	NNS
cord-306921-3afgpunj	268	43	[	[	-LRB-
cord-306921-3afgpunj	268	44	161	161	CD
cord-306921-3afgpunj	268	45	]	]	-RRB-
cord-306921-3afgpunj	268	46	.	.	.
cord-306921-3afgpunj	269	1	From	from	IN
cord-306921-3afgpunj	269	2	this	this	DT
cord-306921-3afgpunj	269	3	study	study	NN
cord-306921-3afgpunj	269	4	,	,	,
cord-306921-3afgpunj	269	5	CV	cv	NN
cord-306921-3afgpunj	269	6	-	-	HYPH
cord-306921-3afgpunj	269	7	B3	B3	NNP
cord-306921-3afgpunj	269	8	is	be	VBZ
cord-306921-3afgpunj	269	9	believed	believe	VBN
cord-306921-3afgpunj	269	10	to	to	TO
cord-306921-3afgpunj	269	11	localize	localize	VB
cord-306921-3afgpunj	269	12	in	in	IN
cord-306921-3afgpunj	269	13	the	the	DT
cord-306921-3afgpunj	269	14	mitochondria	mitochondrion	NNS
cord-306921-3afgpunj	269	15	where	where	WRB
cord-306921-3afgpunj	269	16	it	-PRON-	PRP
cord-306921-3afgpunj	269	17	initiates	initiate	VBZ
cord-306921-3afgpunj	269	18	virus	virus	NN
cord-306921-3afgpunj	269	19	induced	induce	VBN
cord-306921-3afgpunj	269	20	mitophagy	mitophagy	NNP
cord-306921-3afgpunj	269	21	and	and	CC
cord-306921-3afgpunj	269	22	eventual	eventual	JJ
cord-306921-3afgpunj	269	23	escape	escape	NN
cord-306921-3afgpunj	269	24	from	from	IN
cord-306921-3afgpunj	269	25	cells	cell	NNS
cord-306921-3afgpunj	269	26	through	through	IN
cord-306921-3afgpunj	269	27	autophagosomebound	autophagosomebound	NN
cord-306921-3afgpunj	269	28	-	-	HYPH
cord-306921-3afgpunj	269	29	mitochondrion	mitochondrion	NN
cord-306921-3afgpunj	269	30	-	-	HYPH
cord-306921-3afgpunj	269	31	virus	virus	NN
cord-306921-3afgpunj	269	32	complex	complex	NN
cord-306921-3afgpunj	269	33	[	[	-LRB-
cord-306921-3afgpunj	269	34	161	161	CD
cord-306921-3afgpunj	269	35	]	]	-RRB-
cord-306921-3afgpunj	269	36	.	.	.
cord-306921-3afgpunj	270	1	The	the	DT
cord-306921-3afgpunj	270	2	role	role	NN
cord-306921-3afgpunj	270	3	of	of	IN
cord-306921-3afgpunj	270	4	mitophagosome	mitophagosome	NN
cord-306921-3afgpunj	270	5	in	in	IN
cord-306921-3afgpunj	270	6	the	the	DT
cord-306921-3afgpunj	270	7	release	release	NN
cord-306921-3afgpunj	270	8	of	of	IN
cord-306921-3afgpunj	270	9	CV	cv	NN
cord-306921-3afgpunj	270	10	-	-	HYPH
cord-306921-3afgpunj	270	11	B3	B3	NNP
cord-306921-3afgpunj	270	12	virus	virus	NN
cord-306921-3afgpunj	270	13	,	,	,
cord-306921-3afgpunj	270	14	explains	explain	VBZ
cord-306921-3afgpunj	270	15	possible	possible	JJ
cord-306921-3afgpunj	270	16	alternative	alternative	JJ
cord-306921-3afgpunj	270	17	process	process	NN
cord-306921-3afgpunj	270	18	used	use	VBN
cord-306921-3afgpunj	270	19	by	by	IN
cord-306921-3afgpunj	270	20	picornaviruses	picornavirus	NNS
cord-306921-3afgpunj	270	21	to	to	TO
cord-306921-3afgpunj	270	22	release	release	VB
cord-306921-3afgpunj	270	23	from	from	IN
cord-306921-3afgpunj	270	24	infected	infected	JJ
cord-306921-3afgpunj	270	25	cells	cell	NNS
cord-306921-3afgpunj	270	26	and	and	CC
cord-306921-3afgpunj	270	27	infect	infect	VBP
cord-306921-3afgpunj	270	28	other	other	JJ
cord-306921-3afgpunj	270	29	cells	cell	NNS
cord-306921-3afgpunj	270	30	thus	thus	RB
cord-306921-3afgpunj	270	31	ensuring	ensure	VBG
cord-306921-3afgpunj	270	32	the	the	DT
cord-306921-3afgpunj	270	33	infection	infection	NN
cord-306921-3afgpunj	270	34	cycle	cycle	NN
cord-306921-3afgpunj	270	35	is	be	VBZ
cord-306921-3afgpunj	270	36	sustained	sustain	VBN
cord-306921-3afgpunj	270	37	.	.	.
cord-306921-3afgpunj	271	1	The	the	DT
cord-306921-3afgpunj	271	2	disruption	disruption	NN
cord-306921-3afgpunj	271	3	of	of	IN
cord-306921-3afgpunj	271	4	the	the	DT
cord-306921-3afgpunj	271	5	mitochondrial	mitochondrial	JJ
cord-306921-3afgpunj	271	6	dynamics	dynamic	NNS
cord-306921-3afgpunj	271	7	through	through	IN
cord-306921-3afgpunj	271	8	virus	virus	NN
cord-306921-3afgpunj	271	9	induced	induce	VBN
cord-306921-3afgpunj	271	10	stimulation	stimulation	NN
cord-306921-3afgpunj	271	11	of	of	IN
cord-306921-3afgpunj	271	12	DRIP1	drip1	NN
cord-306921-3afgpunj	271	13	to	to	TO
cord-306921-3afgpunj	271	14	block	block	VB
cord-306921-3afgpunj	271	15	virus	virus	NN
cord-306921-3afgpunj	271	16	induced	induce	VBN
cord-306921-3afgpunj	271	17	apoptosis	apoptosis	NN
cord-306921-3afgpunj	271	18	and	and	CC
cord-306921-3afgpunj	271	19	eventual	eventual	JJ
cord-306921-3afgpunj	271	20	persistence	persistence	NN
cord-306921-3afgpunj	271	21	of	of	IN
cord-306921-3afgpunj	271	22	viral	viral	JJ
cord-306921-3afgpunj	271	23	infection	infection	NN
cord-306921-3afgpunj	271	24	has	have	VBZ
cord-306921-3afgpunj	271	25	also	also	RB
cord-306921-3afgpunj	271	26	been	be	VBN
cord-306921-3afgpunj	271	27	observed	observe	VBN
cord-306921-3afgpunj	271	28	in	in	IN
cord-306921-3afgpunj	271	29	HCV	HCV	NNP
cord-306921-3afgpunj	271	30	[	[	-LRB-
cord-306921-3afgpunj	271	31	162	162	CD
cord-306921-3afgpunj	271	32	]	]	-RRB-
cord-306921-3afgpunj	271	33	.	.	.
cord-306921-3afgpunj	272	1	This	this	DT
cord-306921-3afgpunj	272	2	points	point	VBZ
cord-306921-3afgpunj	272	3	to	to	IN
cord-306921-3afgpunj	272	4	the	the	DT
cord-306921-3afgpunj	272	5	fact	fact	NN
cord-306921-3afgpunj	272	6	that	that	IN
cord-306921-3afgpunj	272	7	different	different	JJ
cord-306921-3afgpunj	272	8	single	single	JJ
cord-306921-3afgpunj	272	9	stranded	strand	VBN
cord-306921-3afgpunj	272	10	RNA	RNA	NNP
cord-306921-3afgpunj	272	11	viruses	virus	NNS
cord-306921-3afgpunj	272	12	may	may	MD
cord-306921-3afgpunj	272	13	be	be	VB
cord-306921-3afgpunj	272	14	using	use	VBG
cord-306921-3afgpunj	272	15	the	the	DT
cord-306921-3afgpunj	272	16	same	same	JJ
cord-306921-3afgpunj	272	17	process	process	NN
cord-306921-3afgpunj	272	18	to	to	TO
cord-306921-3afgpunj	272	19	disrupt	disrupt	VB
cord-306921-3afgpunj	272	20	mitochondrial	mitochondrial	JJ
cord-306921-3afgpunj	272	21	traffic	traffic	NN
cord-306921-3afgpunj	272	22	and	and	CC
cord-306921-3afgpunj	272	23	eventual	eventual	JJ
cord-306921-3afgpunj	272	24	apoptosis	apoptosis	NN
cord-306921-3afgpunj	272	25	for	for	IN
cord-306921-3afgpunj	272	26	viral	viral	JJ
cord-306921-3afgpunj	272	27	replication	replication	NN
cord-306921-3afgpunj	272	28	maintenance	maintenance	NN
cord-306921-3afgpunj	272	29	of	of	IN
cord-306921-3afgpunj	272	30	viral	viral	JJ
cord-306921-3afgpunj	272	31	infection	infection	NN
cord-306921-3afgpunj	272	32	cycle	cycle	NN
cord-306921-3afgpunj	272	33	.	.	.
cord-306921-3afgpunj	273	1	Enterovirus	enterovirus	NN
cord-306921-3afgpunj	273	2	A71(EV	A71(EV	NNP
cord-306921-3afgpunj	273	3	-	-	HYPH
cord-306921-3afgpunj	273	4	A71	A71	NNP
cord-306921-3afgpunj	273	5	)	)	-RRB-
cord-306921-3afgpunj	273	6	induced	induce	VBN
cord-306921-3afgpunj	273	7	autophagy	autophagy	NN
cord-306921-3afgpunj	273	8	had	have	VBD
cord-306921-3afgpunj	273	9	been	be	VBN
cord-306921-3afgpunj	273	10	reported	report	VBN
cord-306921-3afgpunj	273	11	both	both	CC
cord-306921-3afgpunj	273	12	in	in	IN
cord-306921-3afgpunj	273	13	vivo	vivo	NN
cord-306921-3afgpunj	273	14	and	and	CC
cord-306921-3afgpunj	273	15	in	in	IN
cord-306921-3afgpunj	273	16	vitro	vitro	FW
cord-306921-3afgpunj	273	17	with	with	IN
cord-306921-3afgpunj	273	18	EV	ev	NN
cord-306921-3afgpunj	273	19	-	-	HYPH
cord-306921-3afgpunj	273	20	A71-VP1	A71-VP1	NNS
cord-306921-3afgpunj	273	21	and	and	CC
cord-306921-3afgpunj	273	22	2C	2c	NN
cord-306921-3afgpunj	273	23	proteins	protein	NNS
cord-306921-3afgpunj	273	24	localizing	localize	VBG
cord-306921-3afgpunj	273	25	with	with	IN
cord-306921-3afgpunj	273	26	microtubule	microtubule	NN
cord-306921-3afgpunj	273	27	-	-	HYPH
cord-306921-3afgpunj	273	28	associated	associate	VBN
cord-306921-3afgpunj	273	29	protein	protein	NN
cord-306921-3afgpunj	273	30	1	1	CD
cord-306921-3afgpunj	273	31	light	light	NN
cord-306921-3afgpunj	273	32	chain	chain	NN
cord-306921-3afgpunj	273	33	3(LC3	3(lc3	CD
cord-306921-3afgpunj	273	34	)	)	-RRB-
cord-306921-3afgpunj	273	35	and	and	CC
cord-306921-3afgpunj	273	36	mannose-6-phosphate	mannose-6-phosphate	NNP
cord-306921-3afgpunj	273	37	receptor	receptor	NN
cord-306921-3afgpunj	273	38	(	(	-LRB-
cord-306921-3afgpunj	273	39	MPR	MPR	NNP
cord-306921-3afgpunj	273	40	)	)	-RRB-
cord-306921-3afgpunj	273	41	resulting	result	VBG
cord-306921-3afgpunj	273	42	in	in	IN
cord-306921-3afgpunj	273	43	the	the	DT
cord-306921-3afgpunj	273	44	formation	formation	NN
cord-306921-3afgpunj	273	45	of	of	IN
cord-306921-3afgpunj	273	46	the	the	DT
cord-306921-3afgpunj	273	47	amphisome	amphisome	NN
cord-306921-3afgpunj	273	48	thereby	thereby	RB
cord-306921-3afgpunj	273	49	increasing	increase	VBG
cord-306921-3afgpunj	273	50	viral	viral	JJ
cord-306921-3afgpunj	273	51	replication	replication	NN
cord-306921-3afgpunj	273	52	[	[	-LRB-
cord-306921-3afgpunj	273	53	163	163	CD
cord-306921-3afgpunj	273	54	,	,	,
cord-306921-3afgpunj	273	55	164	164	CD
cord-306921-3afgpunj	273	56	]	]	-RRB-
cord-306921-3afgpunj	273	57	.	.	.
cord-306921-3afgpunj	274	1	EV	EV	NNP
cord-306921-3afgpunj	274	2	-	-	HYPH
cord-306921-3afgpunj	274	3	A71	A71	NNP
cord-306921-3afgpunj	274	4	2	2	CD
cord-306921-3afgpunj	274	5	BC	BC	NNP
cord-306921-3afgpunj	274	6	non	non	JJ
cord-306921-3afgpunj	274	7	-	-	JJ
cord-306921-3afgpunj	274	8	structural	structural	JJ
cord-306921-3afgpunj	274	9	protein	protein	NN
cord-306921-3afgpunj	274	10	was	be	VBD
cord-306921-3afgpunj	274	11	recently	recently	RB
cord-306921-3afgpunj	274	12	shown	show	VBN
cord-306921-3afgpunj	274	13	to	to	TO
cord-306921-3afgpunj	274	14	trigger	trigger	VB
cord-306921-3afgpunj	274	15	the	the	DT
cord-306921-3afgpunj	274	16	formation	formation	NN
cord-306921-3afgpunj	274	17	of	of	IN
cord-306921-3afgpunj	274	18	autolysosomes	autolysosomes	NNP
cord-306921-3afgpunj	274	19	in	in	IN
cord-306921-3afgpunj	274	20	human	human	JJ
cord-306921-3afgpunj	274	21	rhabdomyosarcoma	rhabdomyosarcoma	NNP
cord-306921-3afgpunj	274	22	cells	cell	NNS
cord-306921-3afgpunj	274	23	thus	thus	RB
cord-306921-3afgpunj	274	24	enhancing	enhance	VBG
cord-306921-3afgpunj	274	25	EV	EV	NNP
cord-306921-3afgpunj	274	26	-	-	HYPH
cord-306921-3afgpunj	274	27	A71	A71	NNP
cord-306921-3afgpunj	274	28	replication	replication	NN
cord-306921-3afgpunj	274	29	[	[	-LRB-
cord-306921-3afgpunj	274	30	165	165	CD
cord-306921-3afgpunj	274	31	]	]	-RRB-
cord-306921-3afgpunj	274	32	.	.	.
cord-306921-3afgpunj	275	1	This	this	DT
cord-306921-3afgpunj	275	2	study	study	NN
cord-306921-3afgpunj	275	3	also	also	RB
cord-306921-3afgpunj	275	4	showed	show	VBD
cord-306921-3afgpunj	275	5	that	that	IN
cord-306921-3afgpunj	275	6	the	the	DT
cord-306921-3afgpunj	275	7	2	2	CD
cord-306921-3afgpunj	275	8	BC	BC	NNP
cord-306921-3afgpunj	275	9	protein	protein	NN
cord-306921-3afgpunj	275	10	interacts	interact	VBZ
cord-306921-3afgpunj	275	11	with	with	IN
cord-306921-3afgpunj	275	12	N	n	CD
cord-306921-3afgpunj	275	13	-	-	HYPH
cord-306921-3afgpunj	275	14	ethylmaleimide	ethylmaleimide	NN
cord-306921-3afgpunj	275	15	-	-	HYPH
cord-306921-3afgpunj	275	16	sensitive	sensitive	JJ
cord-306921-3afgpunj	275	17	factor	factor	NN
cord-306921-3afgpunj	275	18	attachment	attachment	NN
cord-306921-3afgpunj	275	19	receptor	receptor	NN
cord-306921-3afgpunj	275	20	(	(	-LRB-
cord-306921-3afgpunj	275	21	SNARE	snare	NN
cord-306921-3afgpunj	275	22	)	)	-RRB-
cord-306921-3afgpunj	275	23	protein	protein	NN
cord-306921-3afgpunj	275	24	,	,	,
cord-306921-3afgpunj	275	25	syntaxin-17	syntaxin-17	''
cord-306921-3afgpunj	275	26	(	(	-LRB-
cord-306921-3afgpunj	275	27	STX17	STX17	NNP
cord-306921-3afgpunj	275	28	)	)	-RRB-
cord-306921-3afgpunj	275	29	,	,	,
cord-306921-3afgpunj	275	30	synaptosome	synaptosome	NNP
cord-306921-3afgpunj	275	31	associated	associate	VBD
cord-306921-3afgpunj	275	32	protein	protein	NNP
cord-306921-3afgpunj	275	33	29	29	CD
cord-306921-3afgpunj	275	34	(	(	-LRB-
cord-306921-3afgpunj	275	35	SNAP29	SNAP29	NNP
cord-306921-3afgpunj	275	36	)	)	-RRB-
cord-306921-3afgpunj	275	37	and	and	CC
cord-306921-3afgpunj	276	1	microtubule	microtubule	NN
cord-306921-3afgpunj	276	2	-	-	HYPH
cord-306921-3afgpunj	276	3	associated	associate	VBN
cord-306921-3afgpunj	276	4	protein	protein	NN
cord-306921-3afgpunj	276	5	1	1	CD
cord-306921-3afgpunj	276	6	light	light	NN
cord-306921-3afgpunj	276	7	chain	chain	NN
cord-306921-3afgpunj	276	8	3B	3b	NN
cord-306921-3afgpunj	277	1	(	(	-LRB-
cord-306921-3afgpunj	277	2	LC3B	lc3b	NN
cord-306921-3afgpunj	277	3	)	)	-RRB-
cord-306921-3afgpunj	277	4	major	major	JJ
cord-306921-3afgpunj	277	5	players	player	NNS
cord-306921-3afgpunj	277	6	in	in	IN
cord-306921-3afgpunj	277	7	the	the	DT
cord-306921-3afgpunj	277	8	formation	formation	NN
cord-306921-3afgpunj	277	9	of	of	IN
cord-306921-3afgpunj	277	10	the	the	DT
cord-306921-3afgpunj	277	11	autolysosome	autolysosome	NN
cord-306921-3afgpunj	277	12	[	[	-LRB-
cord-306921-3afgpunj	277	13	165	165	CD
cord-306921-3afgpunj	277	14	]	]	-RRB-
cord-306921-3afgpunj	277	15	.	.	.
cord-306921-3afgpunj	278	1	The	the	DT
cord-306921-3afgpunj	278	2	results	result	NNS
cord-306921-3afgpunj	278	3	of	of	IN
cord-306921-3afgpunj	278	4	this	this	DT
cord-306921-3afgpunj	278	5	study	study	NN
cord-306921-3afgpunj	278	6	are	be	VBP
cord-306921-3afgpunj	278	7	consistent	consistent	JJ
cord-306921-3afgpunj	278	8	with	with	IN
cord-306921-3afgpunj	278	9	earlier	early	JJR
cord-306921-3afgpunj	278	10	findings	finding	NNS
cord-306921-3afgpunj	278	11	linking	link	VBG
cord-306921-3afgpunj	278	12	enterovirus	enterovirus	NN
cord-306921-3afgpunj	278	13	2	2	CD
cord-306921-3afgpunj	278	14	BC	BC	NNP
cord-306921-3afgpunj	278	15	non	non	JJ
cord-306921-3afgpunj	278	16	-	-	JJ
cord-306921-3afgpunj	278	17	structural	structural	JJ
cord-306921-3afgpunj	278	18	proteins	protein	NNS
cord-306921-3afgpunj	278	19	to	to	IN
cord-306921-3afgpunj	278	20	the	the	DT
cord-306921-3afgpunj	278	21	exploitation	exploitation	NN
cord-306921-3afgpunj	278	22	of	of	IN
cord-306921-3afgpunj	278	23	autophagy	autophagy	NN
cord-306921-3afgpunj	278	24	process	process	NN
cord-306921-3afgpunj	278	25	to	to	TO
cord-306921-3afgpunj	278	26	support	support	VB
cord-306921-3afgpunj	278	27	enterovirus	enterovirus	NN
cord-306921-3afgpunj	278	28	viral	viral	JJ
cord-306921-3afgpunj	278	29	replication	replication	NN
cord-306921-3afgpunj	278	30	.	.	.
cord-306921-3afgpunj	279	1	Corona	corona	NN
cord-306921-3afgpunj	279	2	and	and	CC
cord-306921-3afgpunj	279	3	colleagues	colleague	NNS
cord-306921-3afgpunj	279	4	showed	show	VBD
cord-306921-3afgpunj	279	5	that	that	IN
cord-306921-3afgpunj	279	6	enterovirus	enterovirus	NN
cord-306921-3afgpunj	279	7	D68(EV	d68(ev	NN
cord-306921-3afgpunj	279	8	-	-	HYPH
cord-306921-3afgpunj	279	9	D68	D68	NNP
cord-306921-3afgpunj	279	10	)	)	-RRB-
cord-306921-3afgpunj	279	11	is	be	VBZ
cord-306921-3afgpunj	279	12	able	able	JJ
cord-306921-3afgpunj	279	13	to	to	TO
cord-306921-3afgpunj	279	14	disrupt	disrupt	VB
cord-306921-3afgpunj	279	15	autophagy	autophagy	NN
cord-306921-3afgpunj	279	16	processes	process	NNS
cord-306921-3afgpunj	279	17	downstream	downstream	RB
cord-306921-3afgpunj	279	18	to	to	TO
cord-306921-3afgpunj	279	19	promote	promote	VB
cord-306921-3afgpunj	279	20	viral	viral	JJ
cord-306921-3afgpunj	279	21	replication	replication	NN
cord-306921-3afgpunj	279	22	and	and	CC
cord-306921-3afgpunj	279	23	eventual	eventual	JJ
cord-306921-3afgpunj	279	24	egress	egress	NN
cord-306921-3afgpunj	279	25	from	from	IN
cord-306921-3afgpunj	279	26	the	the	DT
cord-306921-3afgpunj	279	27	cells	cell	NNS
cord-306921-3afgpunj	279	28	thus	thus	RB
cord-306921-3afgpunj	279	29	promoting	promote	VBG
cord-306921-3afgpunj	279	30	viral	viral	JJ
cord-306921-3afgpunj	279	31	infection	infection	NN
cord-306921-3afgpunj	279	32	within	within	IN
cord-306921-3afgpunj	279	33	the	the	DT
cord-306921-3afgpunj	279	34	cells	cell	NNS
cord-306921-3afgpunj	279	35	[	[	-LRB-
cord-306921-3afgpunj	279	36	166	166	CD
cord-306921-3afgpunj	279	37	]	]	-RRB-
cord-306921-3afgpunj	279	38	.	.	.
cord-306921-3afgpunj	280	1	This	this	DT
cord-306921-3afgpunj	280	2	phenomena	phenomena	NN
cord-306921-3afgpunj	280	3	linking	link	VBG
cord-306921-3afgpunj	280	4	viral	viral	JJ
cord-306921-3afgpunj	280	5	proteins	protein	NNS
cord-306921-3afgpunj	280	6	to	to	TO
cord-306921-3afgpunj	280	7	interact	interact	VB
cord-306921-3afgpunj	280	8	with	with	IN
cord-306921-3afgpunj	280	9	various	various	JJ
cord-306921-3afgpunj	280	10	regulators	regulator	NNS
cord-306921-3afgpunj	280	11	of	of	IN
cord-306921-3afgpunj	280	12	autophagy	autophagy	NN
cord-306921-3afgpunj	280	13	processes	process	NNS
cord-306921-3afgpunj	280	14	for	for	IN
cord-306921-3afgpunj	280	15	efficient	efficient	JJ
cord-306921-3afgpunj	280	16	viral	viral	JJ
cord-306921-3afgpunj	280	17	replication	replication	NN
cord-306921-3afgpunj	280	18	and	and	CC
cord-306921-3afgpunj	280	19	transmission	transmission	NN
cord-306921-3afgpunj	280	20	has	have	VBZ
cord-306921-3afgpunj	280	21	been	be	VBN
cord-306921-3afgpunj	280	22	reviewed	review	VBN
cord-306921-3afgpunj	280	23	[	[	-LRB-
cord-306921-3afgpunj	280	24	167	167	CD
cord-306921-3afgpunj	280	25	,	,	,
cord-306921-3afgpunj	280	26	168	168	CD
cord-306921-3afgpunj	280	27	]	]	-RRB-
cord-306921-3afgpunj	280	28	.	.	.
cord-306921-3afgpunj	281	1	Another	another	DT
cord-306921-3afgpunj	281	2	pending	pende	VBG
cord-306921-3afgpunj	281	3	issue	issue	NN
cord-306921-3afgpunj	281	4	has	have	VBZ
cord-306921-3afgpunj	281	5	been	be	VBN
cord-306921-3afgpunj	281	6	if	if	IN
cord-306921-3afgpunj	281	7	the	the	DT
cord-306921-3afgpunj	281	8	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	281	9	are	be	VBP
cord-306921-3afgpunj	281	10	able	able	JJ
cord-306921-3afgpunj	281	11	to	to	TO
cord-306921-3afgpunj	281	12	replicate	replicate	VB
cord-306921-3afgpunj	281	13	inside	inside	IN
cord-306921-3afgpunj	281	14	the	the	DT
cord-306921-3afgpunj	281	15	acidic	acidic	JJ
cord-306921-3afgpunj	281	16	autophagosomes	autophagosome	NNS
cord-306921-3afgpunj	281	17	and	and	CC
cord-306921-3afgpunj	281	18	how	how	WRB
cord-306921-3afgpunj	281	19	do	do	VBP
cord-306921-3afgpunj	281	20	they	-PRON-	PRP
cord-306921-3afgpunj	281	21	evade	evade	VB
cord-306921-3afgpunj	281	22	degradation	degradation	NN
cord-306921-3afgpunj	281	23	and	and	CC
cord-306921-3afgpunj	281	24	exit	exit	VB
cord-306921-3afgpunj	281	25	the	the	DT
cord-306921-3afgpunj	281	26	cells	cell	NNS
cord-306921-3afgpunj	281	27	intact	intact	JJ
cord-306921-3afgpunj	281	28	.	.	.
cord-306921-3afgpunj	282	1	However	however	RB
cord-306921-3afgpunj	282	2	,	,	,
cord-306921-3afgpunj	282	3	this	this	DT
cord-306921-3afgpunj	282	4	has	have	VBZ
cord-306921-3afgpunj	282	5	so	so	RB
cord-306921-3afgpunj	282	6	far	far	RB
cord-306921-3afgpunj	282	7	been	be	VBN
cord-306921-3afgpunj	282	8	linked	link	VBN
cord-306921-3afgpunj	282	9	to	to	IN
cord-306921-3afgpunj	282	10	the	the	DT
cord-306921-3afgpunj	282	11	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	282	12	'	'	POS
cord-306921-3afgpunj	282	13	ability	ability	NN
cord-306921-3afgpunj	282	14	to	to	TO
cord-306921-3afgpunj	282	15	divert	divert	VB
cord-306921-3afgpunj	282	16	cargo	cargo	NN
cord-306921-3afgpunj	282	17	traffic	traffic	NN
cord-306921-3afgpunj	282	18	away	away	RB
cord-306921-3afgpunj	282	19	from	from	IN
cord-306921-3afgpunj	282	20	degradation	degradation	NN
cord-306921-3afgpunj	282	21	[	[	-LRB-
cord-306921-3afgpunj	282	22	166	166	CD
cord-306921-3afgpunj	282	23	,	,	,
cord-306921-3afgpunj	282	24	169	169	CD
cord-306921-3afgpunj	282	25	,	,	,
cord-306921-3afgpunj	282	26	170	170	CD
cord-306921-3afgpunj	282	27	]	]	-RRB-
cord-306921-3afgpunj	282	28	.	.	.
cord-306921-3afgpunj	283	1	CV	CV	NNP
cord-306921-3afgpunj	283	2	-	-	HYPH
cord-306921-3afgpunj	283	3	B3	B3	NNP
cord-306921-3afgpunj	283	4	3C	3c	NN
cord-306921-3afgpunj	283	5	protease	protease	NN
cord-306921-3afgpunj	283	6	has	have	VBZ
cord-306921-3afgpunj	283	7	been	be	VBN
cord-306921-3afgpunj	283	8	illustrated	illustrate	VBN
cord-306921-3afgpunj	283	9	to	to	TO
cord-306921-3afgpunj	283	10	target	target	VB
cord-306921-3afgpunj	283	11	cleavage	cleavage	NN
cord-306921-3afgpunj	283	12	of	of	IN
cord-306921-3afgpunj	283	13	SNARE	snare	NN
cord-306921-3afgpunj	283	14	and	and	CC
cord-306921-3afgpunj	283	15	PLEKHM1	plekhm1	NN
cord-306921-3afgpunj	283	16	proteins	protein	NNS
cord-306921-3afgpunj	283	17	which	which	WDT
cord-306921-3afgpunj	283	18	are	be	VBP
cord-306921-3afgpunj	283	19	key	key	JJ
cord-306921-3afgpunj	283	20	in	in	IN
cord-306921-3afgpunj	283	21	regulation	regulation	NN
cord-306921-3afgpunj	283	22	of	of	IN
cord-306921-3afgpunj	283	23	autophagosome	autophagosome	JJ
cord-306921-3afgpunj	283	24	fusion	fusion	NN
cord-306921-3afgpunj	283	25	and	and	CC
cord-306921-3afgpunj	283	26	eventually	eventually	RB
cord-306921-3afgpunj	283	27	impairing	impair	VBG
cord-306921-3afgpunj	283	28	establishment	establishment	NN
cord-306921-3afgpunj	283	29	of	of	IN
cord-306921-3afgpunj	283	30	SNARE	snare	NN
cord-306921-3afgpunj	283	31	complexes	complex	NNS
cord-306921-3afgpunj	283	32	[	[	-LRB-
cord-306921-3afgpunj	283	33	170	170	CD
cord-306921-3afgpunj	283	34	]	]	-RRB-
cord-306921-3afgpunj	283	35	.	.	.
cord-306921-3afgpunj	284	1	The	the	DT
cord-306921-3afgpunj	284	2	role	role	NN
cord-306921-3afgpunj	284	3	of	of	IN
cord-306921-3afgpunj	284	4	autophagy	autophagy	NN
cord-306921-3afgpunj	284	5	regulators	regulator	NNS
cord-306921-3afgpunj	284	6	in	in	IN
cord-306921-3afgpunj	284	7	enterovirus	enterovirus	NN
cord-306921-3afgpunj	284	8	infections	infection	NNS
cord-306921-3afgpunj	284	9	have	have	VBP
cord-306921-3afgpunj	284	10	also	also	RB
cord-306921-3afgpunj	284	11	been	be	VBN
cord-306921-3afgpunj	284	12	studied	study	VBN
cord-306921-3afgpunj	284	13	.	.	.
cord-306921-3afgpunj	285	1	For	for	IN
cord-306921-3afgpunj	285	2	example	example	NN
cord-306921-3afgpunj	285	3	,	,	,
cord-306921-3afgpunj	285	4	a	a	DT
cord-306921-3afgpunj	285	5	study	study	NN
cord-306921-3afgpunj	285	6	by	by	IN
cord-306921-3afgpunj	285	7	Delorme	Delorme	NNP
cord-306921-3afgpunj	285	8	-	-	HYPH
cord-306921-3afgpunj	285	9	Axford	Axford	NNP
cord-306921-3afgpunj	285	10	showed	show	VBD
cord-306921-3afgpunj	285	11	that	that	IN
cord-306921-3afgpunj	285	12	an	an	DT
cord-306921-3afgpunj	285	13	autophagy	autophagy	NN
cord-306921-3afgpunj	285	14	regulator	regulator	NN
cord-306921-3afgpunj	285	15	;	;	:
cord-306921-3afgpunj	285	16	bactericidal	bactericidal	JJ
cord-306921-3afgpunj	285	17	/	/	SYM
cord-306921-3afgpunj	285	18	permeability	permeability	NN
cord-306921-3afgpunj	285	19	-	-	HYPH
cord-306921-3afgpunj	285	20	increasing	increase	VBG
cord-306921-3afgpunj	285	21	protein	protein	NN
cord-306921-3afgpunj	285	22	(	(	-LRB-
cord-306921-3afgpunj	285	23	BPI	BPI	NNP
cord-306921-3afgpunj	285	24	)	)	-RRB-
cord-306921-3afgpunj	285	25	foldcontaining	foldcontaine	VBG
cord-306921-3afgpunj	285	26	family	family	NN
cord-306921-3afgpunj	285	27	B	b	NN
cord-306921-3afgpunj	285	28	,	,	,
cord-306921-3afgpunj	285	29	member	member	NN
cord-306921-3afgpunj	285	30	3	3	CD
cord-306921-3afgpunj	285	31	(	(	-LRB-
cord-306921-3afgpunj	285	32	BPIFB3	bpifb3	DT
cord-306921-3afgpunj	285	33	)	)	-RRB-
cord-306921-3afgpunj	285	34	acts	act	VBZ
cord-306921-3afgpunj	285	35	as	as	IN
cord-306921-3afgpunj	285	36	a	a	DT
cord-306921-3afgpunj	285	37	host	host	NN
cord-306921-3afgpunj	285	38	limiting	limit	VBG
cord-306921-3afgpunj	285	39	factor	factor	NN
cord-306921-3afgpunj	285	40	during	during	IN
cord-306921-3afgpunj	285	41	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	285	42	B	B	NNP
cord-306921-3afgpunj	285	43	virus	virus	NN
cord-306921-3afgpunj	285	44	infection	infection	NN
cord-306921-3afgpunj	285	45	[	[	-LRB-
cord-306921-3afgpunj	285	46	158	158	CD
cord-306921-3afgpunj	285	47	]	]	-RRB-
cord-306921-3afgpunj	285	48	.	.	.
cord-306921-3afgpunj	286	1	This	this	DT
cord-306921-3afgpunj	286	2	study	study	NN
cord-306921-3afgpunj	286	3	reported	report	VBD
cord-306921-3afgpunj	286	4	that	that	IN
cord-306921-3afgpunj	286	5	BPIFB3	bpifb3	DT
cord-306921-3afgpunj	286	6	may	may	MD
cord-306921-3afgpunj	286	7	be	be	VB
cord-306921-3afgpunj	286	8	playing	play	VBG
cord-306921-3afgpunj	286	9	a	a	DT
cord-306921-3afgpunj	286	10	role	role	NN
cord-306921-3afgpunj	286	11	in	in	IN
cord-306921-3afgpunj	286	12	downregulating	downregulate	VBG
cord-306921-3afgpunj	286	13	the	the	DT
cord-306921-3afgpunj	286	14	key	key	JJ
cord-306921-3afgpunj	286	15	steps	step	NNS
cord-306921-3afgpunj	286	16	involved	involve	VBN
cord-306921-3afgpunj	286	17	in	in	IN
cord-306921-3afgpunj	286	18	the	the	DT
cord-306921-3afgpunj	286	19	autophagy	autophagy	NN
cord-306921-3afgpunj	286	20	process	process	NN
cord-306921-3afgpunj	286	21	proposed	propose	VBN
cord-306921-3afgpunj	286	22	to	to	TO
cord-306921-3afgpunj	286	23	be	be	VB
cord-306921-3afgpunj	286	24	helping	help	VBG
cord-306921-3afgpunj	286	25	in	in	IN
cord-306921-3afgpunj	286	26	the	the	DT
cord-306921-3afgpunj	286	27	formation	formation	NN
cord-306921-3afgpunj	286	28	of	of	IN
cord-306921-3afgpunj	286	29	the	the	DT
cord-306921-3afgpunj	286	30	membranes	membrane	NNS
cord-306921-3afgpunj	286	31	needed	need	VBN
cord-306921-3afgpunj	286	32	for	for	IN
cord-306921-3afgpunj	286	33	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	286	34	replication	replication	NN
cord-306921-3afgpunj	286	35	[	[	-LRB-
cord-306921-3afgpunj	286	36	158	158	CD
cord-306921-3afgpunj	286	37	]	]	-RRB-
cord-306921-3afgpunj	286	38	.	.	.
cord-306921-3afgpunj	287	1	A	a	DT
cord-306921-3afgpunj	287	2	study	study	NN
cord-306921-3afgpunj	287	3	by	by	IN
cord-306921-3afgpunj	287	4	Morosky	Morosky	NNP
cord-306921-3afgpunj	287	5	and	and	CC
cord-306921-3afgpunj	287	6	colleagues	colleague	NNS
cord-306921-3afgpunj	287	7	linked	link	VBD
cord-306921-3afgpunj	287	8	BPIFB6	BPIFB6	NNP
cord-306921-3afgpunj	287	9	,	,	,
cord-306921-3afgpunj	287	10	another	another	DT
cord-306921-3afgpunj	287	11	protein	protein	NN
cord-306921-3afgpunj	287	12	in	in	IN
cord-306921-3afgpunj	287	13	the	the	DT
cord-306921-3afgpunj	287	14	family	family	NN
cord-306921-3afgpunj	287	15	of	of	IN
cord-306921-3afgpunj	287	16	BPIFB	BPIFB	NNP
cord-306921-3afgpunj	287	17	to	to	TO
cord-306921-3afgpunj	287	18	be	be	VB
cord-306921-3afgpunj	287	19	a	a	DT
cord-306921-3afgpunj	287	20	positive	positive	JJ
cord-306921-3afgpunj	287	21	regulator	regulator	NN
cord-306921-3afgpunj	287	22	of	of	IN
cord-306921-3afgpunj	287	23	CV	cv	NN
cord-306921-3afgpunj	287	24	-	-	HYPH
cord-306921-3afgpunj	287	25	B	b	NN
cord-306921-3afgpunj	287	26	suggesting	suggest	VBG
cord-306921-3afgpunj	287	27	that	that	IN
cord-306921-3afgpunj	287	28	BPIFB	BPIFB	NNP
cord-306921-3afgpunj	287	29	family	family	NN
cord-306921-3afgpunj	287	30	of	of	IN
cord-306921-3afgpunj	287	31	proteins	protein	NNS
cord-306921-3afgpunj	287	32	may	may	MD
cord-306921-3afgpunj	287	33	be	be	VB
cord-306921-3afgpunj	287	34	having	have	VBG
cord-306921-3afgpunj	287	35	diverse	diverse	JJ
cord-306921-3afgpunj	287	36	effects	effect	NNS
cord-306921-3afgpunj	287	37	in	in	IN
cord-306921-3afgpunj	287	38	regulating	regulate	VBG
cord-306921-3afgpunj	287	39	viral	viral	JJ
cord-306921-3afgpunj	287	40	infections	infection	NNS
cord-306921-3afgpunj	287	41	[	[	-LRB-
cord-306921-3afgpunj	287	42	157	157	CD
cord-306921-3afgpunj	287	43	]	]	-RRB-
cord-306921-3afgpunj	287	44	.	.	.
cord-306921-3afgpunj	288	1	A	a	DT
cord-306921-3afgpunj	288	2	recent	recent	JJ
cord-306921-3afgpunj	288	3	study	study	NN
cord-306921-3afgpunj	288	4	by	by	IN
cord-306921-3afgpunj	288	5	Delorme	Delorme	NNP
cord-306921-3afgpunj	288	6	-	-	HYPH
cord-306921-3afgpunj	288	7	Axford	Axford	NNP
cord-306921-3afgpunj	288	8	and	and	CC
cord-306921-3afgpunj	288	9	coworkers	coworker	NNS
cord-306921-3afgpunj	288	10	identified	identify	VBD
cord-306921-3afgpunj	288	11	exoribonuclease	exoribonuclease	NN
cord-306921-3afgpunj	288	12	Xrn1	Xrn1	NNP
cord-306921-3afgpunj	288	13	as	as	IN
cord-306921-3afgpunj	288	14	a	a	DT
cord-306921-3afgpunj	288	15	negative	negative	JJ
cord-306921-3afgpunj	288	16	post	post	JJ
cord-306921-3afgpunj	288	17	-	-	JJ
cord-306921-3afgpunj	288	18	transcriptional	transcriptional	JJ
cord-306921-3afgpunj	288	19	regulator	regulator	NN
cord-306921-3afgpunj	288	20	of	of	IN
cord-306921-3afgpunj	288	21	autophagy	autophagy	NN
cord-306921-3afgpunj	288	22	[	[	-LRB-
cord-306921-3afgpunj	288	23	171	171	CD
cord-306921-3afgpunj	288	24	]	]	-RRB-
cord-306921-3afgpunj	288	25	.	.	.
cord-306921-3afgpunj	289	1	The	the	DT
cord-306921-3afgpunj	289	2	same	same	JJ
cord-306921-3afgpunj	289	3	study	study	NN
cord-306921-3afgpunj	289	4	also	also	RB
cord-306921-3afgpunj	289	5	showed	show	VBD
cord-306921-3afgpunj	289	6	that	that	IN
cord-306921-3afgpunj	289	7	Xrn1	Xrn1	NNP
cord-306921-3afgpunj	289	8	maintains	maintain	VBZ
cord-306921-3afgpunj	289	9	the	the	DT
cord-306921-3afgpunj	289	10	process	process	NN
cord-306921-3afgpunj	289	11	of	of	IN
cord-306921-3afgpunj	289	12	autophagy	autophagy	NN
cord-306921-3afgpunj	289	13	at	at	IN
cord-306921-3afgpunj	289	14	basal	basal	NN
cord-306921-3afgpunj	289	15	levels	level	NNS
cord-306921-3afgpunj	289	16	thus	thus	RB
cord-306921-3afgpunj	289	17	limiting	limit	VBG
cord-306921-3afgpunj	289	18	replication	replication	NN
cord-306921-3afgpunj	289	19	of	of	IN
cord-306921-3afgpunj	289	20	poliovirus	poliovirus	NN
cord-306921-3afgpunj	289	21	and	and	CC
cord-306921-3afgpunj	289	22	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	289	23	B	B	NNP
cord-306921-3afgpunj	289	24	[	[	-LRB-
cord-306921-3afgpunj	289	25	171	171	CD
cord-306921-3afgpunj	289	26	]	]	-RRB-
cord-306921-3afgpunj	289	27	.	.	.
cord-306921-3afgpunj	290	1	A	a	DT
cord-306921-3afgpunj	290	2	recent	recent	JJ
cord-306921-3afgpunj	290	3	study	study	NN
cord-306921-3afgpunj	290	4	by	by	IN
cord-306921-3afgpunj	290	5	Velazquez	Velazquez	NNP
cord-306921-3afgpunj	290	6	and	and	CC
cord-306921-3afgpunj	290	7	colleagues	colleague	NNS
cord-306921-3afgpunj	290	8	demonstrated	demonstrate	VBD
cord-306921-3afgpunj	290	9	that	that	IN
cord-306921-3afgpunj	290	10	poliovirus	poliovirus	NN
cord-306921-3afgpunj	290	11	can	can	MD
cord-306921-3afgpunj	290	12	generate	generate	VB
cord-306921-3afgpunj	290	13	autophagosomes	autophagosome	NNS
cord-306921-3afgpunj	290	14	through	through	IN
cord-306921-3afgpunj	290	15	a	a	DT
cord-306921-3afgpunj	290	16	downstream	downstream	NN
cord-306921-3afgpunj	290	17	of	of	IN
cord-306921-3afgpunj	290	18	ULK1	ULK1	NNP
cord-306921-3afgpunj	290	19	signaling	signal	VBG
cord-306921-3afgpunj	290	20	pathway	pathway	NN
cord-306921-3afgpunj	290	21	;	;	:
cord-306921-3afgpunj	290	22	cleaving	cleave	VBG
cord-306921-3afgpunj	290	23	the	the	DT
cord-306921-3afgpunj	290	24	cargo	cargo	NN
cord-306921-3afgpunj	290	25	traffickers	trafficker	NNS
cord-306921-3afgpunj	290	26	which	which	WDT
cord-306921-3afgpunj	290	27	may	may	MD
cord-306921-3afgpunj	290	28	negatively	negatively	RB
cord-306921-3afgpunj	290	29	interfere	interfere	VB
cord-306921-3afgpunj	290	30	with	with	IN
cord-306921-3afgpunj	290	31	cargo	cargo	NN
cord-306921-3afgpunj	290	32	loading	loading	NN
cord-306921-3afgpunj	290	33	[	[	-LRB-
cord-306921-3afgpunj	290	34	172	172	CD
cord-306921-3afgpunj	290	35	]	]	-RRB-
cord-306921-3afgpunj	290	36	.	.	.
cord-306921-3afgpunj	291	1	This	this	DT
cord-306921-3afgpunj	291	2	points	point	VBZ
cord-306921-3afgpunj	291	3	out	out	RP
cord-306921-3afgpunj	291	4	to	to	IN
cord-306921-3afgpunj	291	5	the	the	DT
cord-306921-3afgpunj	291	6	ability	ability	NN
cord-306921-3afgpunj	291	7	of	of	IN
cord-306921-3afgpunj	291	8	the	the	DT
cord-306921-3afgpunj	291	9	picornaviruses	picornavirus	NNS
cord-306921-3afgpunj	291	10	to	to	IN
cord-306921-3afgpunj	291	11	fine	fine	JJ
cord-306921-3afgpunj	291	12	-	-	HYPH
cord-306921-3afgpunj	291	13	tune	tune	VB
cord-306921-3afgpunj	291	14	the	the	DT
cord-306921-3afgpunj	291	15	interaction	interaction	NN
cord-306921-3afgpunj	291	16	with	with	IN
cord-306921-3afgpunj	291	17	the	the	DT
cord-306921-3afgpunj	291	18	autophagy	autophagy	NN
cord-306921-3afgpunj	291	19	machinery	machinery	NN
cord-306921-3afgpunj	291	20	for	for	IN
cord-306921-3afgpunj	291	21	effective	effective	JJ
cord-306921-3afgpunj	291	22	survival	survival	NN
cord-306921-3afgpunj	291	23	within	within	IN
cord-306921-3afgpunj	291	24	the	the	DT
cord-306921-3afgpunj	291	25	cells	cell	NNS
cord-306921-3afgpunj	291	26	.	.	.
cord-306921-3afgpunj	292	1	Targeting	target	VBG
cord-306921-3afgpunj	292	2	of	of	IN
cord-306921-3afgpunj	292	3	autophagy	autophagy	NN
cord-306921-3afgpunj	292	4	key	key	JJ
cord-306921-3afgpunj	292	5	players	player	NNS
cord-306921-3afgpunj	292	6	and	and	CC
cord-306921-3afgpunj	292	7	auxiliary	auxiliary	JJ
cord-306921-3afgpunj	292	8	factors	factor	NNS
cord-306921-3afgpunj	292	9	have	have	VBP
cord-306921-3afgpunj	292	10	been	be	VBN
cord-306921-3afgpunj	292	11	reported	report	VBN
cord-306921-3afgpunj	292	12	for	for	IN
cord-306921-3afgpunj	292	13	number	number	NN
cord-306921-3afgpunj	292	14	of	of	IN
cord-306921-3afgpunj	292	15	picornaviruses	picornavirus	NNS
cord-306921-3afgpunj	292	16	.	.	.
cord-306921-3afgpunj	293	1	CV	cv	NN
cord-306921-3afgpunj	293	2	-	-	HYPH
cord-306921-3afgpunj	293	3	B3	b3	NN
cord-306921-3afgpunj	293	4	through	through	IN
cord-306921-3afgpunj	293	5	its	-PRON-	PRP$
cord-306921-3afgpunj	293	6	viral	viral	JJ
cord-306921-3afgpunj	293	7	2Aprotease	2Aprotease	NNP
cord-306921-3afgpunj	293	8	was	be	VBD
cord-306921-3afgpunj	293	9	has	have	VBZ
cord-306921-3afgpunj	293	10	been	be	VBN
cord-306921-3afgpunj	293	11	shown	show	VBN
cord-306921-3afgpunj	293	12	to	to	TO
cord-306921-3afgpunj	293	13	cleave	cleave	VB
cord-306921-3afgpunj	293	14	sequestosome	sequestosome	NNP
cord-306921-3afgpunj	293	15	1	1	CD
cord-306921-3afgpunj	293	16	/	/	SYM
cord-306921-3afgpunj	293	17	p62	p62	NN
cord-306921-3afgpunj	293	18	(	(	-LRB-
cord-306921-3afgpunj	293	19	SQSTM1/	SQSTM1/	NNP
cord-306921-3afgpunj	293	20	p62	p62	NN
cord-306921-3afgpunj	293	21	)	)	-RRB-
cord-306921-3afgpunj	293	22	[	[	-LRB-
cord-306921-3afgpunj	293	23	173	173	CD
cord-306921-3afgpunj	293	24	]	]	-RRB-
cord-306921-3afgpunj	293	25	;	;	:
cord-306921-3afgpunj	293	26	a	a	DT
cord-306921-3afgpunj	293	27	known	know	VBN
cord-306921-3afgpunj	293	28	intermediary	intermediary	NN
cord-306921-3afgpunj	293	29	of	of	IN
cord-306921-3afgpunj	293	30	selective	selective	JJ
cord-306921-3afgpunj	293	31	autophagy	autophagy	NN
cord-306921-3afgpunj	293	32	degradation	degradation	NN
cord-306921-3afgpunj	293	33	of	of	IN
cord-306921-3afgpunj	293	34	ubiquitinated	ubiquitinated	JJ
cord-306921-3afgpunj	293	35	proteins	protein	NNS
cord-306921-3afgpunj	293	36	[	[	-LRB-
cord-306921-3afgpunj	293	37	174	174	CD
cord-306921-3afgpunj	293	38	]	]	-RRB-
cord-306921-3afgpunj	293	39	[	[	-LRB-
cord-306921-3afgpunj	293	40	175	175	CD
cord-306921-3afgpunj	293	41	]	]	-RRB-
cord-306921-3afgpunj	293	42	[	[	-LRB-
cord-306921-3afgpunj	293	43	176	176	CD
cord-306921-3afgpunj	293	44	]	]	-RRB-
cord-306921-3afgpunj	293	45	.	.	.
cord-306921-3afgpunj	294	1	This	this	DT
cord-306921-3afgpunj	294	2	study	study	NN
cord-306921-3afgpunj	294	3	further	further	RB
cord-306921-3afgpunj	294	4	showed	show	VBD
cord-306921-3afgpunj	294	5	that	that	IN
cord-306921-3afgpunj	294	6	cleavage	cleavage	NN
cord-306921-3afgpunj	294	7	of	of	IN
cord-306921-3afgpunj	294	8	SQSTM1	SQSTM1	NNS
cord-306921-3afgpunj	294	9	resulted	result	VBN
cord-306921-3afgpunj	294	10	in	in	IN
cord-306921-3afgpunj	294	11	the	the	DT
cord-306921-3afgpunj	294	12	impairment	impairment	NN
cord-306921-3afgpunj	294	13	of	of	IN
cord-306921-3afgpunj	295	1	NF	NF	NNP
cord-306921-3afgpunj	295	2	-	-	HYPH
cord-306921-3afgpunj	295	3	kB	kB	NNP
cord-306921-3afgpunj	295	4	signaling	signal	VBG
cord-306921-3afgpunj	295	5	and	and	CC
cord-306921-3afgpunj	295	6	eventual	eventual	JJ
cord-306921-3afgpunj	295	7	disruption	disruption	NN
cord-306921-3afgpunj	295	8	of	of	IN
cord-306921-3afgpunj	295	9	the	the	DT
cord-306921-3afgpunj	295	10	selective	selective	JJ
cord-306921-3afgpunj	295	11	autophagy	autophagy	NN
cord-306921-3afgpunj	295	12	in	in	IN
cord-306921-3afgpunj	295	13	infected	infected	JJ
cord-306921-3afgpunj	295	14	cells	cell	NNS
cord-306921-3afgpunj	295	15	;	;	:
cord-306921-3afgpunj	295	16	emerging	emerge	VBG
cord-306921-3afgpunj	295	17	as	as	IN
cord-306921-3afgpunj	295	18	an	an	DT
cord-306921-3afgpunj	295	19	pro	pro	JJ
cord-306921-3afgpunj	295	20	-	-	JJ
cord-306921-3afgpunj	295	21	viral	viral	JJ
cord-306921-3afgpunj	295	22	strategy	strategy	NN
cord-306921-3afgpunj	295	23	to	to	TO
cord-306921-3afgpunj	295	24	establish	establish	VB
cord-306921-3afgpunj	295	25	an	an	DT
cord-306921-3afgpunj	295	26	efficient	efficient	JJ
cord-306921-3afgpunj	295	27	infection	infection	NN
cord-306921-3afgpunj	295	28	during	during	IN
cord-306921-3afgpunj	295	29	CV	cv	NN
cord-306921-3afgpunj	295	30	-	-	HYPH
cord-306921-3afgpunj	295	31	B3	b3	NN
cord-306921-3afgpunj	295	32	infection	infection	NN
cord-306921-3afgpunj	295	33	[	[	-LRB-
cord-306921-3afgpunj	295	34	173	173	CD
cord-306921-3afgpunj	295	35	]	]	-RRB-
cord-306921-3afgpunj	295	36	.	.	.
cord-306921-3afgpunj	296	1	A	a	DT
cord-306921-3afgpunj	296	2	subsequent	subsequent	JJ
cord-306921-3afgpunj	296	3	study	study	NN
cord-306921-3afgpunj	296	4	by	by	IN
cord-306921-3afgpunj	296	5	Mohamud	Mohamud	NNP
cord-306921-3afgpunj	296	6	and	and	CC
cord-306921-3afgpunj	296	7	colleagues	colleague	NNS
cord-306921-3afgpunj	296	8	demonstrated	demonstrate	VBD
cord-306921-3afgpunj	296	9	that	that	IN
cord-306921-3afgpunj	296	10	SQSTM1	sqstm1	NN
cord-306921-3afgpunj	296	11	and	and	CC
cord-306921-3afgpunj	296	12	another	another	DT
cord-306921-3afgpunj	296	13	host	host	NN
cord-306921-3afgpunj	296	14	factor	factor	NN
cord-306921-3afgpunj	296	15	calcium	calcium	NN
cord-306921-3afgpunj	296	16	binding	bind	VBG
cord-306921-3afgpunj	296	17	and	and	CC
cord-306921-3afgpunj	296	18	coiled	coil	VBN
cord-306921-3afgpunj	296	19	-	-	HYPH
cord-306921-3afgpunj	296	20	coil	coil	NN
cord-306921-3afgpunj	296	21	domain	domain	NN
cord-306921-3afgpunj	296	22	-	-	HYPH
cord-306921-3afgpunj	296	23	containing	contain	VBG
cord-306921-3afgpunj	296	24	protein	protein	NN
cord-306921-3afgpunj	296	25	2	2	CD
cord-306921-3afgpunj	296	26	/	/	SYM
cord-306921-3afgpunj	296	27	nuclear	nuclear	JJ
cord-306921-3afgpunj	296	28	dot	dot	NN
cord-306921-3afgpunj	296	29	10	10	CD
cord-306921-3afgpunj	296	30	protein	protein	NN
cord-306921-3afgpunj	296	31	52	52	CD
cord-306921-3afgpunj	296	32	(	(	-LRB-
cord-306921-3afgpunj	296	33	CALCOCO2	CALCOCO2	NNS
cord-306921-3afgpunj	296	34	)	)	-RRB-
cord-306921-3afgpunj	296	35	regulate	regulate	VBP
cord-306921-3afgpunj	296	36	CV	cv	NN
cord-306921-3afgpunj	296	37	-	-	HYPH
cord-306921-3afgpunj	296	38	B3	b3	NN
cord-306921-3afgpunj	296	39	virus	virus	NN
cord-306921-3afgpunj	296	40	infection	infection	NN
cord-306921-3afgpunj	296	41	by	by	IN
cord-306921-3afgpunj	296	42	targeting	target	VBG
cord-306921-3afgpunj	296	43	autophagy	autophagy	NN
cord-306921-3afgpunj	296	44	receptors	receptor	NNS
cord-306921-3afgpunj	296	45	;	;	:
cord-306921-3afgpunj	296	46	via	via	IN
cord-306921-3afgpunj	296	47	their	-PRON-	PRP$
cord-306921-3afgpunj	296	48	interaction	interaction	NN
cord-306921-3afgpunj	296	49	with	with	IN
cord-306921-3afgpunj	296	50	viral	viral	JJ
cord-306921-3afgpunj	296	51	protein	protein	NN
cord-306921-3afgpunj	296	52	1	1	CD
cord-306921-3afgpunj	296	53	[	[	-LRB-
cord-306921-3afgpunj	296	54	177	177	CD
cord-306921-3afgpunj	296	55	]	]	-RRB-
cord-306921-3afgpunj	296	56	.	.	.
cord-306921-3afgpunj	297	1	This	this	DT
cord-306921-3afgpunj	297	2	study	study	NN
cord-306921-3afgpunj	297	3	also	also	RB
cord-306921-3afgpunj	297	4	showed	show	VBD
cord-306921-3afgpunj	297	5	that	that	IN
cord-306921-3afgpunj	297	6	CALCOCO2	CALCOCO2	NNS
cord-306921-3afgpunj	297	7	targets	target	NNS
cord-306921-3afgpunj	297	8	mitochondrial	mitochondrial	JJ
cord-306921-3afgpunj	297	9	antiviral	antiviral	JJ
cord-306921-3afgpunj	297	10	signaling	signal	VBG
cord-306921-3afgpunj	297	11	protein	protein	NN
cord-306921-3afgpunj	297	12	for	for	IN
cord-306921-3afgpunj	297	13	degradation	degradation	NN
cord-306921-3afgpunj	297	14	thereby	thereby	RB
cord-306921-3afgpunj	297	15	blocking	block	VBG
cord-306921-3afgpunj	297	16	the	the	DT
cord-306921-3afgpunj	297	17	establishment	establishment	NN
cord-306921-3afgpunj	297	18	of	of	IN
cord-306921-3afgpunj	297	19	antiviral	antiviral	JJ
cord-306921-3afgpunj	297	20	state	state	NN
cord-306921-3afgpunj	297	21	within	within	IN
cord-306921-3afgpunj	297	22	the	the	DT
cord-306921-3afgpunj	297	23	infected	infected	JJ
cord-306921-3afgpunj	297	24	cells	cell	NNS
cord-306921-3afgpunj	297	25	for	for	IN
cord-306921-3afgpunj	297	26	efficient	efficient	JJ
cord-306921-3afgpunj	297	27	establishment	establishment	NN
cord-306921-3afgpunj	297	28	of	of	IN
cord-306921-3afgpunj	297	29	CV	cv	NN
cord-306921-3afgpunj	297	30	-	-	HYPH
cord-306921-3afgpunj	297	31	B3	b3	NN
cord-306921-3afgpunj	297	32	infection	infection	NN
cord-306921-3afgpunj	297	33	[	[	-LRB-
cord-306921-3afgpunj	297	34	177	177	CD
cord-306921-3afgpunj	297	35	]	]	-RRB-
cord-306921-3afgpunj	297	36	.	.	.
cord-306921-3afgpunj	298	1	Different	different	JJ
cord-306921-3afgpunj	298	2	strategies	strategy	NNS
cord-306921-3afgpunj	298	3	used	use	VBN
cord-306921-3afgpunj	298	4	by	by	IN
cord-306921-3afgpunj	298	5	viruses	virus	NNS
cord-306921-3afgpunj	298	6	to	to	TO
cord-306921-3afgpunj	298	7	trigger	trigger	VB
cord-306921-3afgpunj	298	8	and	and	CC
cord-306921-3afgpunj	298	9	hijack	hijack	VB
cord-306921-3afgpunj	298	10	the	the	DT
cord-306921-3afgpunj	298	11	process	process	NN
cord-306921-3afgpunj	298	12	of	of	IN
cord-306921-3afgpunj	298	13	autophagy	autophagy	NN
cord-306921-3afgpunj	298	14	have	have	VBP
cord-306921-3afgpunj	298	15	been	be	VBN
cord-306921-3afgpunj	298	16	recently	recently	RB
cord-306921-3afgpunj	298	17	reviewed	review	VBN
cord-306921-3afgpunj	298	18	in	in	IN
cord-306921-3afgpunj	298	19	details	detail	NNS
cord-306921-3afgpunj	298	20	by	by	IN
cord-306921-3afgpunj	298	21	Zhang	Zhang	NNP
cord-306921-3afgpunj	298	22	and	and	CC
cord-306921-3afgpunj	298	23	coworkers	coworker	NNS
cord-306921-3afgpunj	298	24	[	[	-LRB-
cord-306921-3afgpunj	298	25	178	178	CD
cord-306921-3afgpunj	298	26	]	]	-RRB-
cord-306921-3afgpunj	298	27	.	.	.
cord-306921-3afgpunj	299	1	Autophagy	Autophagy	NNP
cord-306921-3afgpunj	299	2	is	be	VBZ
cord-306921-3afgpunj	299	3	key	key	JJ
cord-306921-3afgpunj	299	4	in	in	IN
cord-306921-3afgpunj	299	5	controlling	control	VBG
cord-306921-3afgpunj	299	6	various	various	JJ
cord-306921-3afgpunj	299	7	cellular	cellular	JJ
cord-306921-3afgpunj	299	8	processes	process	NNS
cord-306921-3afgpunj	299	9	including	include	VBG
cord-306921-3afgpunj	299	10	enhancing	enhance	VBG
cord-306921-3afgpunj	299	11	innate	innate	JJ
cord-306921-3afgpunj	299	12	immune	immune	JJ
cord-306921-3afgpunj	299	13	signaling	signaling	NN
cord-306921-3afgpunj	299	14	during	during	IN
cord-306921-3afgpunj	299	15	viral	viral	JJ
cord-306921-3afgpunj	299	16	infections	infection	NNS
cord-306921-3afgpunj	299	17	through	through	IN
cord-306921-3afgpunj	299	18	a	a	DT
cord-306921-3afgpunj	299	19	process	process	NN
cord-306921-3afgpunj	299	20	known	know	VBN
cord-306921-3afgpunj	299	21	as	as	IN
cord-306921-3afgpunj	299	22	virophagy	virophagy	NNP
cord-306921-3afgpunj	299	23	.	.	.
cord-306921-3afgpunj	300	1	The	the	DT
cord-306921-3afgpunj	300	2	ability	ability	NN
cord-306921-3afgpunj	300	3	of	of	IN
cord-306921-3afgpunj	300	4	virus	virus	NN
cord-306921-3afgpunj	300	5	infected	infect	VBN
cord-306921-3afgpunj	300	6	mitophagosomes	mitophagosomes	NNP
cord-306921-3afgpunj	300	7	to	to	TO
cord-306921-3afgpunj	300	8	be	be	VB
cord-306921-3afgpunj	300	9	released	release	VBN
cord-306921-3afgpunj	300	10	out	out	IN
cord-306921-3afgpunj	300	11	of	of	IN
cord-306921-3afgpunj	300	12	the	the	DT
cord-306921-3afgpunj	300	13	infected	infected	JJ
cord-306921-3afgpunj	300	14	cells	cell	NNS
cord-306921-3afgpunj	300	15	provides	provide	VBZ
cord-306921-3afgpunj	300	16	an	an	DT
cord-306921-3afgpunj	300	17	important	important	JJ
cord-306921-3afgpunj	300	18	mechanism	mechanism	NN
cord-306921-3afgpunj	300	19	of	of	IN
cord-306921-3afgpunj	300	20	virus	virus	NN
cord-306921-3afgpunj	300	21	egress	egress	NN
cord-306921-3afgpunj	300	22	from	from	IN
cord-306921-3afgpunj	300	23	the	the	DT
cord-306921-3afgpunj	300	24	infected	infected	JJ
cord-306921-3afgpunj	300	25	cells	cell	NNS
cord-306921-3afgpunj	300	26	.	.	.
cord-306921-3afgpunj	301	1	Enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	301	2	have	have	VBP
cord-306921-3afgpunj	301	3	been	be	VBN
cord-306921-3afgpunj	301	4	shown	show	VBN
cord-306921-3afgpunj	301	5	to	to	TO
cord-306921-3afgpunj	301	6	have	have	VB
cord-306921-3afgpunj	301	7	the	the	DT
cord-306921-3afgpunj	301	8	ability	ability	NN
cord-306921-3afgpunj	301	9	of	of	IN
cord-306921-3afgpunj	301	10	interacting	interact	VBG
cord-306921-3afgpunj	301	11	with	with	IN
cord-306921-3afgpunj	301	12	cellular	cellular	JJ
cord-306921-3afgpunj	301	13	autophagic	autophagic	NN
cord-306921-3afgpunj	301	14	process	process	NN
cord-306921-3afgpunj	301	15	that	that	WDT
cord-306921-3afgpunj	301	16	is	be	VBZ
cord-306921-3afgpunj	301	17	conventionally	conventionally	RB
cord-306921-3afgpunj	301	18	known	know	VBN
cord-306921-3afgpunj	301	19	to	to	TO
cord-306921-3afgpunj	301	20	degrade	degrade	VB
cord-306921-3afgpunj	301	21	the	the	DT
cord-306921-3afgpunj	301	22	mitochondrial	mitochondrial	JJ
cord-306921-3afgpunj	301	23	traffic	traffic	NN
cord-306921-3afgpunj	301	24	upon	upon	IN
cord-306921-3afgpunj	301	25	fusion	fusion	NN
cord-306921-3afgpunj	301	26	with	with	IN
cord-306921-3afgpunj	301	27	the	the	DT
cord-306921-3afgpunj	301	28	lysosomes	lysosome	NNS
cord-306921-3afgpunj	301	29	.	.	.
cord-306921-3afgpunj	302	1	Enteroviruses	Enteroviruses	NNP
cord-306921-3afgpunj	302	2	has	have	VBZ
cord-306921-3afgpunj	302	3	evolved	evolve	VBN
cord-306921-3afgpunj	302	4	ways	way	NNS
cord-306921-3afgpunj	302	5	to	to	TO
cord-306921-3afgpunj	302	6	evade	evade	VB
cord-306921-3afgpunj	302	7	this	this	DT
cord-306921-3afgpunj	302	8	process	process	NN
cord-306921-3afgpunj	302	9	through	through	IN
cord-306921-3afgpunj	302	10	degradation	degradation	NN
cord-306921-3afgpunj	302	11	of	of	IN
cord-306921-3afgpunj	302	12	various	various	JJ
cord-306921-3afgpunj	302	13	autophagy	autophagy	NN
cord-306921-3afgpunj	302	14	initiating	initiate	VBG
cord-306921-3afgpunj	302	15	factors	factor	NNS
cord-306921-3afgpunj	302	16	as	as	RB
cord-306921-3afgpunj	302	17	well	well	RB
cord-306921-3afgpunj	302	18	as	as	IN
cord-306921-3afgpunj	302	19	its	-PRON-	PRP$
cord-306921-3afgpunj	302	20	regulators	regulator	NNS
cord-306921-3afgpunj	302	21	.	.	.
cord-306921-3afgpunj	303	1	This	this	DT
cord-306921-3afgpunj	303	2	host	host	NN
cord-306921-3afgpunj	303	3	cellular	cellular	JJ
cord-306921-3afgpunj	303	4	process	process	NN
cord-306921-3afgpunj	303	5	has	have	VBZ
cord-306921-3afgpunj	303	6	been	be	VBN
cord-306921-3afgpunj	303	7	linked	link	VBN
cord-306921-3afgpunj	303	8	to	to	IN
cord-306921-3afgpunj	303	9	the	the	DT
cord-306921-3afgpunj	303	10	non	non	JJ
cord-306921-3afgpunj	303	11	-	-	JJ
cord-306921-3afgpunj	303	12	lytic	lytic	JJ
cord-306921-3afgpunj	303	13	exit	exit	NN
cord-306921-3afgpunj	303	14	of	of	IN
cord-306921-3afgpunj	303	15	various	various	JJ
cord-306921-3afgpunj	303	16	enterovirus	enterovirus	NN
cord-306921-3afgpunj	303	17	infections	infection	NNS
cord-306921-3afgpunj	303	18	including	include	VBG
cord-306921-3afgpunj	303	19	Poliovirus	Poliovirus	NNP
cord-306921-3afgpunj	303	20	,	,	,
cord-306921-3afgpunj	303	21	Echovirus	Echovirus	NNP
cord-306921-3afgpunj	303	22	7	7	CD
cord-306921-3afgpunj	303	23	,	,	,
cord-306921-3afgpunj	303	24	EVA71	EVA71	NNP
cord-306921-3afgpunj	303	25	and	and	CC
cord-306921-3afgpunj	303	26	CV	CV	NNP
cord-306921-3afgpunj	303	27	-	-	HYPH
cord-306921-3afgpunj	303	28	B3	b3	NN
cord-306921-3afgpunj	303	29	viruses	virus	NNS
cord-306921-3afgpunj	303	30	.	.	.
cord-306921-3afgpunj	304	1	However	however	RB
cord-306921-3afgpunj	304	2	,	,	,
cord-306921-3afgpunj	304	3	blocking	block	VBG
cord-306921-3afgpunj	304	4	initiation	initiation	NN
cord-306921-3afgpunj	304	5	of	of	IN
cord-306921-3afgpunj	304	6	mitophagy	mitophagy	NNS
cord-306921-3afgpunj	304	7	as	as	IN
cord-306921-3afgpunj	304	8	a	a	DT
cord-306921-3afgpunj	304	9	way	way	NN
cord-306921-3afgpunj	304	10	of	of	IN
cord-306921-3afgpunj	304	11	controlling	control	VBG
cord-306921-3afgpunj	304	12	viral	viral	JJ
cord-306921-3afgpunj	304	13	infections	infection	NNS
cord-306921-3afgpunj	304	14	may	may	MD
cord-306921-3afgpunj	304	15	not	not	RB
cord-306921-3afgpunj	304	16	be	be	VB
cord-306921-3afgpunj	304	17	feasible	feasible	JJ
cord-306921-3afgpunj	304	18	given	give	VBN
cord-306921-3afgpunj	305	1	that	that	IN
cord-306921-3afgpunj	305	2	observations	observation	NNS
cord-306921-3afgpunj	305	3	from	from	IN
cord-306921-3afgpunj	305	4	different	different	JJ
cord-306921-3afgpunj	305	5	studies	study	NNS
cord-306921-3afgpunj	305	6	have	have	VBP
cord-306921-3afgpunj	305	7	shown	show	VBN
cord-306921-3afgpunj	305	8	only	only	RB
cord-306921-3afgpunj	305	9	disruption	disruption	NN
cord-306921-3afgpunj	305	10	of	of	IN
cord-306921-3afgpunj	305	11	extracellular	extracellular	JJ
cord-306921-3afgpunj	305	12	micro	micro	NNS
cord-306921-3afgpunj	305	13	-	-	NNS
cord-306921-3afgpunj	305	14	vesicles	vesicle	NNS
cord-306921-3afgpunj	305	15	(	(	-LRB-
cord-306921-3afgpunj	305	16	EMV	EMV	NNP
cord-306921-3afgpunj	305	17	)	)	-RRB-
cord-306921-3afgpunj	305	18	release	release	NN
cord-306921-3afgpunj	305	19	and	and	CC
cord-306921-3afgpunj	305	20	not	not	RB
cord-306921-3afgpunj	305	21	the	the	DT
cord-306921-3afgpunj	305	22	replication	replication	NN
cord-306921-3afgpunj	305	23	ability	ability	NN
cord-306921-3afgpunj	305	24	of	of	IN
cord-306921-3afgpunj	305	25	CV	cv	NN
cord-306921-3afgpunj	305	26	-	-	HYPH
cord-306921-3afgpunj	305	27	B3	B3	NNP
cord-306921-3afgpunj	305	28	virus	virus	NN
cord-306921-3afgpunj	305	29	.	.	.
cord-306921-3afgpunj	306	1	Thus	thus	RB
cord-306921-3afgpunj	306	2	,	,	,
cord-306921-3afgpunj	306	3	this	this	DT
cord-306921-3afgpunj	306	4	process	process	NN
cord-306921-3afgpunj	306	5	does	do	VBZ
cord-306921-3afgpunj	306	6	not	not	RB
cord-306921-3afgpunj	306	7	provide	provide	VB
cord-306921-3afgpunj	306	8	an	an	DT
cord-306921-3afgpunj	306	9	ideal	ideal	JJ
cord-306921-3afgpunj	306	10	antiviral	antiviral	JJ
cord-306921-3afgpunj	306	11	target	target	NN
cord-306921-3afgpunj	306	12	.	.	.
cord-306921-3afgpunj	307	1	An	an	DT
cord-306921-3afgpunj	307	2	overview	overview	NN
cord-306921-3afgpunj	307	3	of	of	IN
cord-306921-3afgpunj	307	4	the	the	DT
cord-306921-3afgpunj	307	5	human	human	JJ
cord-306921-3afgpunj	307	6	host	host	NN
cord-306921-3afgpunj	307	7	cell	cell	NN
cord-306921-3afgpunj	307	8	/	/	SYM
cord-306921-3afgpunj	307	9	process	process	NN
cord-306921-3afgpunj	307	10	:	:	:
cord-306921-3afgpunj	307	11	NPEV	NPEV	NNP
cord-306921-3afgpunj	307	12	viral	viral	JJ
cord-306921-3afgpunj	307	13	protein	protein	NN
cord-306921-3afgpunj	307	14	interactions	interaction	NNS
cord-306921-3afgpunj	307	15	are	be	VBP
cord-306921-3afgpunj	307	16	highlighted	highlight	VBN
cord-306921-3afgpunj	307	17	in	in	IN
cord-306921-3afgpunj	307	18	Table	Table	NNP
cord-306921-3afgpunj	307	19	2	2	CD
cord-306921-3afgpunj	307	20	below	below	RB
cord-306921-3afgpunj	307	21	.	.	.
cord-306921-3afgpunj	308	1	Much	much	JJ
cord-306921-3afgpunj	308	2	has	have	VBZ
cord-306921-3afgpunj	308	3	not	not	RB
cord-306921-3afgpunj	308	4	been	be	VBN
cord-306921-3afgpunj	308	5	achieved	achieve	VBN
cord-306921-3afgpunj	308	6	in	in	IN
cord-306921-3afgpunj	308	7	the	the	DT
cord-306921-3afgpunj	308	8	development	development	NN
cord-306921-3afgpunj	308	9	of	of	IN
cord-306921-3afgpunj	308	10	antivirals	antiviral	NNS
cord-306921-3afgpunj	308	11	against	against	IN
cord-306921-3afgpunj	308	12	NPEV	NPEV	NNP
cord-306921-3afgpunj	308	13	infections	infection	NNS
cord-306921-3afgpunj	308	14	.	.	.
cord-306921-3afgpunj	309	1	The	the	DT
cord-306921-3afgpunj	309	2	major	major	JJ
cord-306921-3afgpunj	309	3	challenge	challenge	NN
cord-306921-3afgpunj	309	4	for	for	IN
cord-306921-3afgpunj	309	5	development	development	NN
cord-306921-3afgpunj	309	6	of	of	IN
cord-306921-3afgpunj	309	7	the	the	DT
cord-306921-3afgpunj	309	8	antivirals	antiviral	NNS
cord-306921-3afgpunj	309	9	has	have	VBZ
cord-306921-3afgpunj	309	10	always	always	RB
cord-306921-3afgpunj	309	11	been	be	VBN
cord-306921-3afgpunj	309	12	the	the	DT
cord-306921-3afgpunj	309	13	mutations	mutation	NNS
cord-306921-3afgpunj	309	14	on	on	IN
cord-306921-3afgpunj	309	15	the	the	DT
cord-306921-3afgpunj	309	16	viral	viral	JJ
cord-306921-3afgpunj	309	17	genomes	genome	NNS
cord-306921-3afgpunj	309	18	.	.	.
cord-306921-3afgpunj	310	1	Several	several	JJ
cord-306921-3afgpunj	310	2	compounds	compound	NNS
cord-306921-3afgpunj	310	3	have	have	VBP
cord-306921-3afgpunj	310	4	been	be	VBN
cord-306921-3afgpunj	310	5	tested	test	VBN
cord-306921-3afgpunj	310	6	for	for	IN
cord-306921-3afgpunj	310	7	possible	possible	JJ
cord-306921-3afgpunj	310	8	use	use	NN
cord-306921-3afgpunj	310	9	as	as	IN
cord-306921-3afgpunj	310	10	antivirals	antiviral	NNS
cord-306921-3afgpunj	310	11	against	against	IN
cord-306921-3afgpunj	310	12	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	310	13	as	as	IN
cord-306921-3afgpunj	310	14	shown	show	VBN
cord-306921-3afgpunj	310	15	in	in	IN
cord-306921-3afgpunj	310	16	Table	Table	NNP
cord-306921-3afgpunj	310	17	3	3	CD
cord-306921-3afgpunj	310	18	below	below	RB
cord-306921-3afgpunj	311	1	but	but	CC
cord-306921-3afgpunj	311	2	no	no	DT
cord-306921-3afgpunj	311	3	much	much	JJ
cord-306921-3afgpunj	311	4	success	success	NN
cord-306921-3afgpunj	311	5	has	have	VBZ
cord-306921-3afgpunj	311	6	been	be	VBN
cord-306921-3afgpunj	311	7	achieved	achieve	VBN
cord-306921-3afgpunj	311	8	.	.	.
cord-306921-3afgpunj	312	1	Most	Most	JJS
cord-306921-3afgpunj	312	2	of	of	IN
cord-306921-3afgpunj	312	3	the	the	DT
cord-306921-3afgpunj	312	4	drug	drug	NN
cord-306921-3afgpunj	312	5	screening	screening	NN
cord-306921-3afgpunj	312	6	have	have	VBP
cord-306921-3afgpunj	312	7	been	be	VBN
cord-306921-3afgpunj	312	8	done	do	VBN
cord-306921-3afgpunj	312	9	in	in	IN
cord-306921-3afgpunj	312	10	vitro	vitro	FW
cord-306921-3afgpunj	312	11	with	with	IN
cord-306921-3afgpunj	312	12	little	little	JJ
cord-306921-3afgpunj	312	13	success	success	NN
cord-306921-3afgpunj	312	14	in	in	IN
cord-306921-3afgpunj	312	15	vivo	vivo	NN
cord-306921-3afgpunj	312	16	and	and	CC
cord-306921-3afgpunj	312	17	in	in	IN
cord-306921-3afgpunj	312	18	clinical	clinical	JJ
cord-306921-3afgpunj	312	19	trials	trial	NNS
cord-306921-3afgpunj	312	20	.	.	.
cord-306921-3afgpunj	313	1	Screening	screen	VBG
cord-306921-3afgpunj	313	2	FDA	FDA	NNP
cord-306921-3afgpunj	313	3	approved	approve	VBD
cord-306921-3afgpunj	313	4	drugs	drug	NNS
cord-306921-3afgpunj	313	5	and	and	CC
cord-306921-3afgpunj	313	6	repurposing	repurposing	NN
cord-306921-3afgpunj	313	7	of	of	IN
cord-306921-3afgpunj	313	8	existing	exist	VBG
cord-306921-3afgpunj	313	9	drugs	drug	NNS
cord-306921-3afgpunj	313	10	based	base	VBN
cord-306921-3afgpunj	313	11	on	on	IN
cord-306921-3afgpunj	313	12	known	know	VBN
cord-306921-3afgpunj	313	13	viral	viral	JJ
cord-306921-3afgpunj	313	14	-	-	HYPH
cord-306921-3afgpunj	313	15	human	human	JJ
cord-306921-3afgpunj	313	16	protein	protein	NN
cord-306921-3afgpunj	313	17	interactions	interaction	NNS
cord-306921-3afgpunj	314	1	are	be	VBP
cord-306921-3afgpunj	314	2	some	some	DT
cord-306921-3afgpunj	314	3	of	of	IN
cord-306921-3afgpunj	314	4	the	the	DT
cord-306921-3afgpunj	314	5	strategies	strategy	NNS
cord-306921-3afgpunj	314	6	that	that	WDT
cord-306921-3afgpunj	314	7	has	have	VBZ
cord-306921-3afgpunj	314	8	been	be	VBN
cord-306921-3afgpunj	314	9	adopted	adopt	VBN
cord-306921-3afgpunj	314	10	by	by	IN
cord-306921-3afgpunj	314	11	scientists	scientist	NNS
cord-306921-3afgpunj	314	12	to	to	TO
cord-306921-3afgpunj	314	13	identify	identify	VB
cord-306921-3afgpunj	314	14	antivirals	antiviral	NNS
cord-306921-3afgpunj	314	15	against	against	IN
cord-306921-3afgpunj	314	16	NPEVs	npev	NNS
cord-306921-3afgpunj	314	17	.	.	.
cord-306921-3afgpunj	315	1	For	for	IN
cord-306921-3afgpunj	315	2	example	example	NN
cord-306921-3afgpunj	315	3	,	,	,
cord-306921-3afgpunj	315	4	Li	Li	NNP
cord-306921-3afgpunj	315	5	and	and	CC
cord-306921-3afgpunj	315	6	colleagues	colleague	NNS
cord-306921-3afgpunj	315	7	evaluated	evaluate	VBD
cord-306921-3afgpunj	315	8	the	the	DT
cord-306921-3afgpunj	315	9	effects	effect	NNS
cord-306921-3afgpunj	315	10	of	of	IN
cord-306921-3afgpunj	315	11	ribavirin	ribavirin	FW
cord-306921-3afgpunj	315	12	a	a	DT
cord-306921-3afgpunj	315	13	known	know	VBN
cord-306921-3afgpunj	315	14	antiviral	antiviral	JJ
cord-306921-3afgpunj	315	15	against	against	IN
cord-306921-3afgpunj	315	16	other	other	JJ
cord-306921-3afgpunj	315	17	RNA	RNA	NNP
cord-306921-3afgpunj	315	18	viruses	virus	NNS
cord-306921-3afgpunj	315	19	on	on	IN
cord-306921-3afgpunj	315	20	EV	EV	NNP
cord-306921-3afgpunj	315	21	-	-	HYPH
cord-306921-3afgpunj	315	22	A71	A71	NNP
cord-306921-3afgpunj	315	23	for	for	IN
cord-306921-3afgpunj	315	24	possible	possible	JJ
cord-306921-3afgpunj	315	25	repurposing	repurposing	NN
cord-306921-3afgpunj	315	26	of	of	IN
cord-306921-3afgpunj	315	27	the	the	DT
cord-306921-3afgpunj	315	28	drug	drug	NN
cord-306921-3afgpunj	315	29	[	[	-LRB-
cord-306921-3afgpunj	315	30	179	179	CD
cord-306921-3afgpunj	315	31	]	]	-RRB-
cord-306921-3afgpunj	315	32	.	.	.
cord-306921-3afgpunj	316	1	Their	-PRON-	PRP$
cord-306921-3afgpunj	316	2	study	study	NN
cord-306921-3afgpunj	316	3	showed	show	VBD
cord-306921-3afgpunj	316	4	decreased	decrease	VBD
cord-306921-3afgpunj	316	5	EV	EV	NNP
cord-306921-3afgpunj	316	6	-	-	HYPH
cord-306921-3afgpunj	316	7	A71	A71	NNP
cord-306921-3afgpunj	316	8	virus	virus	NN
cord-306921-3afgpunj	316	9	yield	yield	NN
cord-306921-3afgpunj	316	10	in	in	IN
cord-306921-3afgpunj	316	11	vitro	vitro	FW
cord-306921-3afgpunj	316	12	and	and	CC
cord-306921-3afgpunj	316	13	reduced	reduced	JJ
cord-306921-3afgpunj	316	14	disease	disease	NN
cord-306921-3afgpunj	316	15	status	status	NN
cord-306921-3afgpunj	316	16	,	,	,
cord-306921-3afgpunj	316	17	death	death	NN
cord-306921-3afgpunj	316	18	and	and	CC
cord-306921-3afgpunj	316	19	adverse	adverse	JJ
cord-306921-3afgpunj	316	20	effects	effect	NNS
cord-306921-3afgpunj	316	21	associated	associate	VBN
cord-306921-3afgpunj	316	22	with	with	IN
cord-306921-3afgpunj	316	23	its	-PRON-	PRP$
cord-306921-3afgpunj	316	24	infection	infection	NN
cord-306921-3afgpunj	316	25	in	in	IN
cord-306921-3afgpunj	316	26	vivo	vivo	NN
cord-306921-3afgpunj	316	27	;	;	:
cord-306921-3afgpunj	316	28	highlighting	highlight	VBG
cord-306921-3afgpunj	316	29	the	the	DT
cord-306921-3afgpunj	316	30	possible	possible	JJ
cord-306921-3afgpunj	316	31	role	role	NN
cord-306921-3afgpunj	316	32	as	as	IN
cord-306921-3afgpunj	316	33	an	an	DT
cord-306921-3afgpunj	316	34	antiviral	antiviral	JJ
cord-306921-3afgpunj	316	35	compound	compound	NN
cord-306921-3afgpunj	316	36	against	against	IN
cord-306921-3afgpunj	316	37	EV	EV	NNP
cord-306921-3afgpunj	316	38	-	-	HYPH
cord-306921-3afgpunj	316	39	A71	A71	NNP
cord-306921-3afgpunj	316	40	[	[	-LRB-
cord-306921-3afgpunj	316	41	179	179	CD
cord-306921-3afgpunj	316	42	]	]	-RRB-
cord-306921-3afgpunj	316	43	.	.	.
cord-306921-3afgpunj	317	1	Plant	plant	NN
cord-306921-3afgpunj	317	2	metabolites	metabolite	NNS
cord-306921-3afgpunj	317	3	have	have	VBP
cord-306921-3afgpunj	317	4	also	also	RB
cord-306921-3afgpunj	317	5	been	be	VBN
cord-306921-3afgpunj	317	6	targeted	target	VBN
cord-306921-3afgpunj	317	7	as	as	IN
cord-306921-3afgpunj	317	8	possible	possible	JJ
cord-306921-3afgpunj	317	9	antiviral	antiviral	JJ
cord-306921-3afgpunj	317	10	compounds	compound	NNS
cord-306921-3afgpunj	317	11	against	against	IN
cord-306921-3afgpunj	317	12	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	317	13	.	.	.
cord-306921-3afgpunj	318	1	For	for	IN
cord-306921-3afgpunj	318	2	example	example	NN
cord-306921-3afgpunj	318	3	,	,	,
cord-306921-3afgpunj	318	4	Quercetin	Quercetin	NNP
cord-306921-3afgpunj	318	5	;	;	:
cord-306921-3afgpunj	318	6	a	a	DT
cord-306921-3afgpunj	318	7	well	well	RB
cord-306921-3afgpunj	318	8	distributed	distribute	VBN
cord-306921-3afgpunj	318	9	plant	plant	NN
cord-306921-3afgpunj	318	10	flavonoid	flavonoid	NN
cord-306921-3afgpunj	318	11	has	have	VBZ
cord-306921-3afgpunj	318	12	been	be	VBN
cord-306921-3afgpunj	318	13	shown	show	VBN
cord-306921-3afgpunj	318	14	recently	recently	RB
cord-306921-3afgpunj	318	15	to	to	TO
cord-306921-3afgpunj	318	16	inhibit	inhibit	VB
cord-306921-3afgpunj	318	17	EV	ev	NN
cord-306921-3afgpunj	318	18	-	-	HYPH
cord-306921-3afgpunj	318	19	A71	A71	NNP
cord-306921-3afgpunj	318	20	infection	infection	NN
cord-306921-3afgpunj	318	21	by	by	IN
cord-306921-3afgpunj	318	22	inhibiting	inhibit	VBG
cord-306921-3afgpunj	318	23	virus	virus	NN
cord-306921-3afgpunj	318	24	attachment	attachment	NN
cord-306921-3afgpunj	318	25	,	,	,
cord-306921-3afgpunj	318	26	adsorption	adsorption	NN
cord-306921-3afgpunj	318	27	and	and	CC
cord-306921-3afgpunj	318	28	by	by	IN
cord-306921-3afgpunj	318	29	targeting	target	VBG
cord-306921-3afgpunj	318	30	viral	viral	JJ
cord-306921-3afgpunj	318	31	3C	3C	NNP
cord-306921-3afgpunj	318	32	protease	protease	NN
cord-306921-3afgpunj	318	33	[	[	-LRB-
cord-306921-3afgpunj	318	34	180	180	CD
cord-306921-3afgpunj	318	35	]	]	-RRB-
cord-306921-3afgpunj	318	36	.	.	.
cord-306921-3afgpunj	319	1	The	the	DT
cord-306921-3afgpunj	319	2	antiviral	antiviral	JJ
cord-306921-3afgpunj	319	3	efficacy	efficacy	NN
cord-306921-3afgpunj	319	4	of	of	IN
cord-306921-3afgpunj	319	5	pyrazolo	pyrazolo	NNP
cord-306921-3afgpunj	319	6	[	[	-LRB-
cord-306921-3afgpunj	319	7	3,4-d	3,4-d	NNP
cord-306921-3afgpunj	319	8	]	]	-RRB-
cord-306921-3afgpunj	319	9	pyrimidines	pyrimidine	NNS
cord-306921-3afgpunj	319	10	have	have	VBP
cord-306921-3afgpunj	319	11	also	also	RB
cord-306921-3afgpunj	319	12	been	be	VBN
cord-306921-3afgpunj	319	13	evaluated	evaluate	VBN
cord-306921-3afgpunj	319	14	against	against	IN
cord-306921-3afgpunj	319	15	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	319	16	;	;	:
cord-306921-3afgpunj	319	17	CV	cv	NN
cord-306921-3afgpunj	319	18	-	-	HYPH
cord-306921-3afgpunj	319	19	B3	b3	NN
cord-306921-3afgpunj	319	20	and	and	CC
cord-306921-3afgpunj	319	21	EV	EV	NNP
cord-306921-3afgpunj	319	22	-	-	HYPH
cord-306921-3afgpunj	319	23	A71	A71	NNP
cord-306921-3afgpunj	319	24	virus	virus	NN
cord-306921-3afgpunj	319	25	infections	infection	NNS
cord-306921-3afgpunj	319	26	where	where	WRB
cord-306921-3afgpunj	319	27	they	-PRON-	PRP
cord-306921-3afgpunj	319	28	inhibited	inhibit	VBD
cord-306921-3afgpunj	319	29	their	-PRON-	PRP$
cord-306921-3afgpunj	319	30	infections	infection	NNS
cord-306921-3afgpunj	319	31	but	but	CC
cord-306921-3afgpunj	319	32	the	the	DT
cord-306921-3afgpunj	319	33	exact	exact	JJ
cord-306921-3afgpunj	319	34	mechanism	mechanism	NN
cord-306921-3afgpunj	319	35	was	be	VBD
cord-306921-3afgpunj	319	36	not	not	RB
cord-306921-3afgpunj	319	37	established	establish	VBN
cord-306921-3afgpunj	319	38	[	[	-LRB-
cord-306921-3afgpunj	319	39	181	181	CD
cord-306921-3afgpunj	319	40	]	]	-RRB-
cord-306921-3afgpunj	319	41	.	.	.
cord-306921-3afgpunj	320	1	More	more	RBR
cord-306921-3afgpunj	320	2	recently	recently	RB
cord-306921-3afgpunj	320	3	,	,	,
cord-306921-3afgpunj	320	4	andrographolide	andrographolide	NNP
cord-306921-3afgpunj	320	5	has	have	VBZ
cord-306921-3afgpunj	320	6	been	be	VBN
cord-306921-3afgpunj	320	7	reported	report	VBN
cord-306921-3afgpunj	320	8	to	to	TO
cord-306921-3afgpunj	320	9	suppress	suppress	VB
cord-306921-3afgpunj	320	10	EV	EV	NNP
cord-306921-3afgpunj	320	11	-	-	HYPH
cord-306921-3afgpunj	320	12	D68	D68	NNP
cord-306921-3afgpunj	320	13	replication	replication	NN
cord-306921-3afgpunj	320	14	targeting	target	VBG
cord-306921-3afgpunj	320	15	the	the	DT
cord-306921-3afgpunj	320	16	viral	viral	JJ
cord-306921-3afgpunj	320	17	maturation	maturation	NN
cord-306921-3afgpunj	320	18	within	within	IN
cord-306921-3afgpunj	320	19	the	the	DT
cord-306921-3afgpunj	320	20	acidified	acidified	JJ
cord-306921-3afgpunj	320	21	endosomes	endosome	NNS
cord-306921-3afgpunj	320	22	[	[	-LRB-
cord-306921-3afgpunj	320	23	182	182	CD
cord-306921-3afgpunj	320	24	]	]	-RRB-
cord-306921-3afgpunj	320	25	.	.	.
cord-306921-3afgpunj	321	1	World	World	NNP
cord-306921-3afgpunj	321	2	Health	Health	NNP
cord-306921-3afgpunj	321	3	organization	organization	NN
cord-306921-3afgpunj	321	4	(	(	-LRB-
cord-306921-3afgpunj	321	5	WHO	who	WP
cord-306921-3afgpunj	321	6	)	)	-RRB-
cord-306921-3afgpunj	321	7	recommended	recommend	VBD
cord-306921-3afgpunj	321	8	combination	combination	NN
cord-306921-3afgpunj	321	9	therapy	therapy	NN
cord-306921-3afgpunj	321	10	has	have	VBZ
cord-306921-3afgpunj	321	11	also	also	RB
cord-306921-3afgpunj	321	12	been	be	VBN
cord-306921-3afgpunj	321	13	evaluated	evaluate	VBN
cord-306921-3afgpunj	321	14	for	for	IN
cord-306921-3afgpunj	321	15	possible	possible	JJ
cord-306921-3afgpunj	321	16	antiviral	antiviral	JJ
cord-306921-3afgpunj	321	17	development	development	NN
cord-306921-3afgpunj	321	18	against	against	IN
cord-306921-3afgpunj	321	19	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	321	20	[	[	-LRB-
cord-306921-3afgpunj	321	21	183	183	CD
cord-306921-3afgpunj	321	22	]	]	-RRB-
cord-306921-3afgpunj	321	23	.	.	.
cord-306921-3afgpunj	322	1	Screening	screening	NN
cord-306921-3afgpunj	322	2	of	of	IN
cord-306921-3afgpunj	322	3	FDA	FDA	NNP
cord-306921-3afgpunj	322	4	approved	approve	VBD
cord-306921-3afgpunj	322	5	drugs	drug	NNS
cord-306921-3afgpunj	322	6	recognized	recognize	VBD
cord-306921-3afgpunj	322	7	pirlindole	pirlindole	NN
cord-306921-3afgpunj	322	8	as	as	IN
cord-306921-3afgpunj	322	9	a	a	DT
cord-306921-3afgpunj	322	10	strong	strong	JJ
cord-306921-3afgpunj	322	11	inhibitor	inhibitor	NN
cord-306921-3afgpunj	322	12	of	of	IN
cord-306921-3afgpunj	322	13	CV	cv	NN
cord-306921-3afgpunj	322	14	-	-	HYPH
cord-306921-3afgpunj	322	15	B3	B3	NNP
cord-306921-3afgpunj	322	16	[	[	-LRB-
cord-306921-3afgpunj	322	17	184	184	CD
cord-306921-3afgpunj	322	18	]	]	-RRB-
cord-306921-3afgpunj	322	19	.	.	.
cord-306921-3afgpunj	323	1	Natural	natural	JJ
cord-306921-3afgpunj	323	2	products	product	NNS
cord-306921-3afgpunj	323	3	have	have	VBP
cord-306921-3afgpunj	323	4	recently	recently	RB
cord-306921-3afgpunj	323	5	gained	gain	VBN
cord-306921-3afgpunj	323	6	much	much	JJ
cord-306921-3afgpunj	323	7	interest	interest	NN
cord-306921-3afgpunj	323	8	in	in	IN
cord-306921-3afgpunj	323	9	drug	drug	NN
cord-306921-3afgpunj	323	10	development	development	NN
cord-306921-3afgpunj	323	11	studies	study	NNS
cord-306921-3afgpunj	323	12	.	.	.
cord-306921-3afgpunj	324	1	Of	of	IN
cord-306921-3afgpunj	324	2	these	these	DT
cord-306921-3afgpunj	324	3	;	;	:
cord-306921-3afgpunj	324	4	plant	plant	VB
cord-306921-3afgpunj	324	5	secondary	secondary	JJ
cord-306921-3afgpunj	324	6	metabolites	metabolite	NNS
cord-306921-3afgpunj	324	7	;	;	:
cord-306921-3afgpunj	324	8	flavonoids	flavonoid	NNS
cord-306921-3afgpunj	324	9	have	have	VBP
cord-306921-3afgpunj	324	10	been	be	VBN
cord-306921-3afgpunj	324	11	of	of	IN
cord-306921-3afgpunj	324	12	interest	interest	NN
cord-306921-3afgpunj	324	13	in	in	IN
cord-306921-3afgpunj	324	14	drug	drug	NN
cord-306921-3afgpunj	324	15	therapy	therapy	NN
cord-306921-3afgpunj	324	16	screens	screen	NNS
cord-306921-3afgpunj	324	17	against	against	IN
cord-306921-3afgpunj	324	18	viral	viral	JJ
cord-306921-3afgpunj	324	19	infections	infection	NNS
cord-306921-3afgpunj	324	20	given	give	VBN
cord-306921-3afgpunj	324	21	that	that	IN
cord-306921-3afgpunj	324	22	they	-PRON-	PRP
cord-306921-3afgpunj	324	23	are	be	VBP
cord-306921-3afgpunj	324	24	freely	freely	RB
cord-306921-3afgpunj	324	25	available	available	JJ
cord-306921-3afgpunj	324	26	and	and	CC
cord-306921-3afgpunj	324	27	form	form	VB
cord-306921-3afgpunj	324	28	better	well	JJR
cord-306921-3afgpunj	324	29	part	part	NN
cord-306921-3afgpunj	324	30	of	of	IN
cord-306921-3afgpunj	324	31	human	human	JJ
cord-306921-3afgpunj	324	32	dietary	dietary	NN
cord-306921-3afgpunj	324	33	.	.	.
cord-306921-3afgpunj	325	1	Screening	screening	NN
cord-306921-3afgpunj	325	2	of	of	IN
cord-306921-3afgpunj	325	3	plant	plant	NN
cord-306921-3afgpunj	325	4	metabolites	metabolite	NNS
cord-306921-3afgpunj	325	5	for	for	IN
cord-306921-3afgpunj	325	6	possible	possible	JJ
cord-306921-3afgpunj	325	7	use	use	NN
cord-306921-3afgpunj	325	8	as	as	IN
cord-306921-3afgpunj	325	9	antiviral	antiviral	JJ
cord-306921-3afgpunj	325	10	therapy	therapy	NN
cord-306921-3afgpunj	325	11	has	have	VBZ
cord-306921-3afgpunj	325	12	been	be	VBN
cord-306921-3afgpunj	325	13	reported	report	VBN
cord-306921-3afgpunj	325	14	as	as	IN
cord-306921-3afgpunj	325	15	reviewed	review	VBN
cord-306921-3afgpunj	325	16	by	by	IN
cord-306921-3afgpunj	325	17	Zakaryan	Zakaryan	NNP
cord-306921-3afgpunj	325	18	and	and	CC
cord-306921-3afgpunj	325	19	colleagues	colleague	NNS
cord-306921-3afgpunj	325	20	[	[	-LRB-
cord-306921-3afgpunj	325	21	185	185	CD
cord-306921-3afgpunj	325	22	]	]	-RRB-
cord-306921-3afgpunj	325	23	and	and	CC
cord-306921-3afgpunj	325	24	their	-PRON-	PRP$
cord-306921-3afgpunj	325	25	biological	biological	JJ
cord-306921-3afgpunj	325	26	activity	activity	NN
cord-306921-3afgpunj	325	27	as	as	RB
cord-306921-3afgpunj	325	28	well	well	RB
cord-306921-3afgpunj	325	29	as	as	IN
cord-306921-3afgpunj	325	30	chemistry	chemistry	NN
cord-306921-3afgpunj	325	31	have	have	VBP
cord-306921-3afgpunj	325	32	also	also	RB
cord-306921-3afgpunj	325	33	been	be	VBN
cord-306921-3afgpunj	325	34	extensively	extensively	RB
cord-306921-3afgpunj	325	35	reviewed	review	VBN
cord-306921-3afgpunj	325	36	[	[	-LRB-
cord-306921-3afgpunj	325	37	186	186	CD
cord-306921-3afgpunj	325	38	]	]	-RRB-
cord-306921-3afgpunj	325	39	.	.	.
cord-306921-3afgpunj	326	1	Some	some	DT
cord-306921-3afgpunj	326	2	flavonoids	flavonoid	NNS
cord-306921-3afgpunj	326	3	with	with	IN
cord-306921-3afgpunj	326	4	antiviral	antiviral	JJ
cord-306921-3afgpunj	326	5	abilities	ability	NNS
cord-306921-3afgpunj	326	6	in	in	IN
cord-306921-3afgpunj	326	7	vitro	vitro	FW
cord-306921-3afgpunj	326	8	against	against	IN
cord-306921-3afgpunj	326	9	viral	viral	JJ
cord-306921-3afgpunj	326	10	infections	infection	NNS
cord-306921-3afgpunj	326	11	include	include	VBP
cord-306921-3afgpunj	326	12	;	;	:
cord-306921-3afgpunj	326	13	isoquercitrin	isoquercitrin	NNS
cord-306921-3afgpunj	326	14	against	against	IN
cord-306921-3afgpunj	326	15	Zika	Zika	NNP
cord-306921-3afgpunj	326	16	virus	virus	NN
cord-306921-3afgpunj	326	17	infections	infection	NNS
cord-306921-3afgpunj	326	18	[	[	-LRB-
cord-306921-3afgpunj	326	19	187	187	CD
cord-306921-3afgpunj	326	20	]	]	-RRB-
cord-306921-3afgpunj	326	21	,	,	,
cord-306921-3afgpunj	326	22	chikungunya	chikungunya	NN
cord-306921-3afgpunj	326	23	infections	infection	NNS
cord-306921-3afgpunj	326	24	[	[	-LRB-
cord-306921-3afgpunj	326	25	188	188	CD
cord-306921-3afgpunj	326	26	]	]	-RRB-
cord-306921-3afgpunj	326	27	,	,	,
cord-306921-3afgpunj	326	28	apigenin	apigenin	JJ
cord-306921-3afgpunj	326	29	antiviral	antiviral	JJ
cord-306921-3afgpunj	326	30	effects	effect	NNS
cord-306921-3afgpunj	326	31	on	on	IN
cord-306921-3afgpunj	326	32	a	a	DT
cord-306921-3afgpunj	326	33	number	number	NN
cord-306921-3afgpunj	326	34	of	of	IN
cord-306921-3afgpunj	326	35	viruses	virus	NNS
cord-306921-3afgpunj	326	36	such	such	JJ
cord-306921-3afgpunj	326	37	as	as	IN
cord-306921-3afgpunj	326	38	African	african	JJ
cord-306921-3afgpunj	326	39	swine	swine	NN
cord-306921-3afgpunj	326	40	fever	fever	NN
cord-306921-3afgpunj	326	41	virus	virus	NN
cord-306921-3afgpunj	326	42	(	(	-LRB-
cord-306921-3afgpunj	326	43	ASFV	ASFV	NNP
cord-306921-3afgpunj	326	44	)	)	-RRB-
cord-306921-3afgpunj	326	45	,	,	,
cord-306921-3afgpunj	326	46	hepatitis	hepatitis	NN
cord-306921-3afgpunj	326	47	C	C	NNP
cord-306921-3afgpunj	326	48	virus	virus	NN
cord-306921-3afgpunj	326	49	[	[	-LRB-
cord-306921-3afgpunj	326	50	189	189	CD
cord-306921-3afgpunj	326	51	,	,	,
cord-306921-3afgpunj	326	52	190	190	CD
cord-306921-3afgpunj	326	53	]	]	-RRB-
cord-306921-3afgpunj	326	54	.	.	.
cord-306921-3afgpunj	327	1	Apigenin	Apigenin	NNS
cord-306921-3afgpunj	327	2	have	have	VBP
cord-306921-3afgpunj	327	3	also	also	RB
cord-306921-3afgpunj	327	4	shown	show	VBN
cord-306921-3afgpunj	327	5	antiviral	antiviral	JJ
cord-306921-3afgpunj	327	6	activity	activity	NN
cord-306921-3afgpunj	327	7	against	against	IN
cord-306921-3afgpunj	327	8	EV	EV	NNP
cord-306921-3afgpunj	327	9	-	-	HYPH
cord-306921-3afgpunj	327	10	A71	A71	NNP
cord-306921-3afgpunj	327	11	virus	virus	NN
cord-306921-3afgpunj	327	12	by	by	IN
cord-306921-3afgpunj	327	13	inhibiting	inhibit	VBG
cord-306921-3afgpunj	327	14	viral	viral	JJ
cord-306921-3afgpunj	327	15	IRES	ires	JJ
cord-306921-3afgpunj	327	16	dependent	dependent	JJ
cord-306921-3afgpunj	327	17	translation	translation	NN
cord-306921-3afgpunj	327	18	[	[	-LRB-
cord-306921-3afgpunj	327	19	191	191	CD
cord-306921-3afgpunj	327	20	]	]	-RRB-
cord-306921-3afgpunj	327	21	[	[	-LRB-
cord-306921-3afgpunj	327	22	192	192	CD
cord-306921-3afgpunj	327	23	]	]	-RRB-
cord-306921-3afgpunj	327	24	[	[	-LRB-
cord-306921-3afgpunj	327	25	193	193	CD
cord-306921-3afgpunj	327	26	]	]	-RRB-
cord-306921-3afgpunj	327	27	.	.	.
cord-306921-3afgpunj	328	1	A	a	DT
cord-306921-3afgpunj	328	2	recent	recent	JJ
cord-306921-3afgpunj	328	3	screen	screen	NN
cord-306921-3afgpunj	328	4	of	of	IN
cord-306921-3afgpunj	328	5	flavonoid	flavonoid	NN
cord-306921-3afgpunj	328	6	library	library	NN
cord-306921-3afgpunj	328	7	identified	identify	VBD
cord-306921-3afgpunj	328	8	ST077124	ST077124	NNP
cord-306921-3afgpunj	328	9	and	and	CC
cord-306921-3afgpunj	328	10	ST024734	ST024734	NNS
cord-306921-3afgpunj	328	11	as	as	IN
cord-306921-3afgpunj	328	12	lead	lead	JJ
cord-306921-3afgpunj	328	13	antiviral	antiviral	JJ
cord-306921-3afgpunj	328	14	compounds	compound	NNS
cord-306921-3afgpunj	328	15	against	against	IN
cord-306921-3afgpunj	328	16	EV	EV	NNP
cord-306921-3afgpunj	328	17	-	-	HYPH
cord-306921-3afgpunj	328	18	A71	A71	NNP
cord-306921-3afgpunj	328	19	,	,	,
cord-306921-3afgpunj	328	20	CV	CV	NNP
cord-306921-3afgpunj	328	21	-	-	HYPH
cord-306921-3afgpunj	328	22	A6	A6	NNP
cord-306921-3afgpunj	328	23	and	and	CC
cord-306921-3afgpunj	328	24	CV	CV	NNP
cord-306921-3afgpunj	328	25	-	-	HYPH
cord-306921-3afgpunj	328	26	A16	a16	NN
cord-306921-3afgpunj	328	27	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	328	28	[	[	-LRB-
cord-306921-3afgpunj	328	29	194	194	CD
cord-306921-3afgpunj	328	30	]	]	-RRB-
cord-306921-3afgpunj	328	31	.	.	.
cord-306921-3afgpunj	329	1	All	all	PDT
cord-306921-3afgpunj	329	2	these	these	DT
cord-306921-3afgpunj	329	3	concerted	concerted	JJ
cord-306921-3afgpunj	329	4	efforts	effort	NNS
cord-306921-3afgpunj	329	5	towards	towards	IN
cord-306921-3afgpunj	329	6	identifying	identify	VBG
cord-306921-3afgpunj	329	7	antivirals	antiviral	NNS
cord-306921-3afgpunj	329	8	against	against	IN
cord-306921-3afgpunj	329	9	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	329	10	and	and	CC
cord-306921-3afgpunj	329	11	other	other	JJ
cord-306921-3afgpunj	329	12	viral	viral	JJ
cord-306921-3afgpunj	329	13	infections	infection	NNS
cord-306921-3afgpunj	329	14	needs	need	VBZ
cord-306921-3afgpunj	329	15	a	a	DT
cord-306921-3afgpunj	329	16	follow	follow	NN
cord-306921-3afgpunj	329	17	-	-	HYPH
cord-306921-3afgpunj	329	18	up	up	NN
cord-306921-3afgpunj	329	19	and	and	CC
cord-306921-3afgpunj	329	20	validation	validation	NN
cord-306921-3afgpunj	329	21	in	in	IN
cord-306921-3afgpunj	329	22	animal	animal	NN
cord-306921-3afgpunj	329	23	models	model	NNS
cord-306921-3afgpunj	329	24	.	.	.
cord-306921-3afgpunj	330	1	The	the	DT
cord-306921-3afgpunj	330	2	good	good	JJ
cord-306921-3afgpunj	330	3	news	news	NN
cord-306921-3afgpunj	330	4	is	be	VBZ
cord-306921-3afgpunj	330	5	that	that	IN
cord-306921-3afgpunj	330	6	most	most	JJS
cord-306921-3afgpunj	330	7	of	of	IN
cord-306921-3afgpunj	330	8	the	the	DT
cord-306921-3afgpunj	330	9	already	already	RB
cord-306921-3afgpunj	330	10	identified	identify	VBN
cord-306921-3afgpunj	330	11	compounds	compound	NNS
cord-306921-3afgpunj	330	12	have	have	VBP
cord-306921-3afgpunj	330	13	shown	show	VBN
cord-306921-3afgpunj	330	14	no	no	DT
cord-306921-3afgpunj	330	15	cytotoxicity	cytotoxicity	NN
cord-306921-3afgpunj	330	16	in	in	IN
cord-306921-3afgpunj	330	17	cells	cell	NNS
cord-306921-3afgpunj	330	18	;	;	:
cord-306921-3afgpunj	330	19	thus	thus	RB
cord-306921-3afgpunj	330	20	,	,	,
cord-306921-3afgpunj	330	21	may	may	MD
cord-306921-3afgpunj	330	22	not	not	RB
cord-306921-3afgpunj	330	23	have	have	VB
cord-306921-3afgpunj	330	24	toxic	toxic	JJ
cord-306921-3afgpunj	330	25	effects	effect	NNS
cord-306921-3afgpunj	330	26	in	in	IN
cord-306921-3afgpunj	330	27	animal	animal	NN
cord-306921-3afgpunj	330	28	models	model	NNS
cord-306921-3afgpunj	330	29	.	.	.
cord-306921-3afgpunj	331	1	The	the	DT
cord-306921-3afgpunj	331	2	efficacy	efficacy	NN
cord-306921-3afgpunj	331	3	of	of	IN
cord-306921-3afgpunj	331	4	most	most	JJS
cord-306921-3afgpunj	331	5	of	of	IN
cord-306921-3afgpunj	331	6	the	the	DT
cord-306921-3afgpunj	331	7	identified	identify	VBN
cord-306921-3afgpunj	331	8	compounds	compound	NNS
cord-306921-3afgpunj	331	9	have	have	VBP
cord-306921-3afgpunj	331	10	only	only	RB
cord-306921-3afgpunj	331	11	been	be	VBN
cord-306921-3afgpunj	331	12	elucidated	elucidate	VBN
cord-306921-3afgpunj	331	13	in	in	IN
cord-306921-3afgpunj	331	14	vitro	vitro	FW
cord-306921-3afgpunj	332	1	thus	thus	RB
cord-306921-3afgpunj	332	2	there	there	EX
cord-306921-3afgpunj	332	3	is	be	VBZ
cord-306921-3afgpunj	332	4	need	need	NN
cord-306921-3afgpunj	332	5	for	for	IN
cord-306921-3afgpunj	332	6	further	further	JJ
cord-306921-3afgpunj	332	7	studies	study	NNS
cord-306921-3afgpunj	332	8	to	to	TO
cord-306921-3afgpunj	332	9	identify	identify	VB
cord-306921-3afgpunj	332	10	their	-PRON-	PRP$
cord-306921-3afgpunj	332	11	effects	effect	NNS
cord-306921-3afgpunj	332	12	in	in	IN
cord-306921-3afgpunj	332	13	vitro	vitro	FW
cord-306921-3afgpunj	332	14	.	.	.
cord-306921-3afgpunj	333	1	Little	little	JJ
cord-306921-3afgpunj	333	2	success	success	NN
cord-306921-3afgpunj	333	3	has	have	VBZ
cord-306921-3afgpunj	333	4	been	be	VBN
cord-306921-3afgpunj	333	5	achieved	achieve	VBN
cord-306921-3afgpunj	333	6	in	in	IN
cord-306921-3afgpunj	333	7	terms	term	NNS
cord-306921-3afgpunj	333	8	of	of	IN
cord-306921-3afgpunj	333	9	antiviral	antiviral	JJ
cord-306921-3afgpunj	333	10	therapy	therapy	NN
cord-306921-3afgpunj	333	11	against	against	IN
cord-306921-3afgpunj	333	12	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	333	13	.	.	.
cord-306921-3afgpunj	334	1	Given	give	VBN
cord-306921-3afgpunj	334	2	that	that	DT
cord-306921-3afgpunj	334	3	drug	drug	NN
cord-306921-3afgpunj	334	4	discovery	discovery	NN
cord-306921-3afgpunj	334	5	process	process	NN
cord-306921-3afgpunj	334	6	is	be	VBZ
cord-306921-3afgpunj	334	7	an	an	DT
cord-306921-3afgpunj	334	8	expensive	expensive	JJ
cord-306921-3afgpunj	334	9	and	and	CC
cord-306921-3afgpunj	334	10	time	time	NN
cord-306921-3afgpunj	334	11	-	-	HYPH
cord-306921-3afgpunj	334	12	consuming	consume	VBG
cord-306921-3afgpunj	334	13	venture	venture	NN
cord-306921-3afgpunj	334	14	,	,	,
cord-306921-3afgpunj	334	15	most	most	JJS
cord-306921-3afgpunj	334	16	researchers	researcher	NNS
cord-306921-3afgpunj	334	17	have	have	VBP
cord-306921-3afgpunj	334	18	relied	rely	VBN
cord-306921-3afgpunj	334	19	on	on	IN
cord-306921-3afgpunj	334	20	the	the	DT
cord-306921-3afgpunj	334	21	FDA	FDA	NNP
cord-306921-3afgpunj	334	22	approved	approve	VBD
cord-306921-3afgpunj	334	23	drugs	drug	NNS
cord-306921-3afgpunj	334	24	or	or	CC
cord-306921-3afgpunj	334	25	drugs	drug	NNS
cord-306921-3afgpunj	334	26	that	that	WDT
cord-306921-3afgpunj	334	27	are	be	VBP
cord-306921-3afgpunj	334	28	already	already	RB
cord-306921-3afgpunj	334	29	in	in	IN
cord-306921-3afgpunj	334	30	use	use	NN
cord-306921-3afgpunj	334	31	for	for	IN
cord-306921-3afgpunj	334	32	possible	possible	JJ
cord-306921-3afgpunj	334	33	repurposing	repurposing	NN
cord-306921-3afgpunj	334	34	.	.	.
cord-306921-3afgpunj	335	1	Not	not	RB
cord-306921-3afgpunj	335	2	much	much	JJ
cord-306921-3afgpunj	335	3	success	success	NN
cord-306921-3afgpunj	335	4	on	on	IN
cord-306921-3afgpunj	335	5	drug	drug	NN
cord-306921-3afgpunj	335	6	therapy	therapy	NN
cord-306921-3afgpunj	335	7	has	have	VBZ
cord-306921-3afgpunj	335	8	been	be	VBN
cord-306921-3afgpunj	335	9	recorded	record	VBN
cord-306921-3afgpunj	335	10	in	in	IN
cord-306921-3afgpunj	335	11	viral	viral	JJ
cord-306921-3afgpunj	335	12	infections	infection	NNS
cord-306921-3afgpunj	335	13	due	due	JJ
cord-306921-3afgpunj	335	14	to	to	IN
cord-306921-3afgpunj	335	15	the	the	DT
cord-306921-3afgpunj	335	16	high	high	JJ
cord-306921-3afgpunj	335	17	mutation	mutation	NN
cord-306921-3afgpunj	335	18	rates	rate	NNS
cord-306921-3afgpunj	335	19	observed	observe	VBN
cord-306921-3afgpunj	335	20	during	during	IN
cord-306921-3afgpunj	335	21	viral	viral	JJ
cord-306921-3afgpunj	335	22	replication	replication	NN
cord-306921-3afgpunj	335	23	.	.	.
cord-306921-3afgpunj	336	1	Combination	combination	NN
cord-306921-3afgpunj	336	2	therapy	therapy	NN
cord-306921-3afgpunj	336	3	of	of	IN
cord-306921-3afgpunj	336	4	the	the	DT
cord-306921-3afgpunj	336	5	drugs	drug	NNS
cord-306921-3afgpunj	336	6	with	with	IN
cord-306921-3afgpunj	336	7	different	different	JJ
cord-306921-3afgpunj	336	8	mode	mode	NN
cord-306921-3afgpunj	336	9	of	of	IN
cord-306921-3afgpunj	336	10	actions	action	NNS
cord-306921-3afgpunj	337	1	EV	ev	NN
cord-306921-3afgpunj	337	2	-	-	HYPH
cord-306921-3afgpunj	337	3	A71-VP1	A71-VP1	NNS
cord-306921-3afgpunj	337	4	and	and	CC
cord-306921-3afgpunj	337	5	2C	2c	NN
cord-306921-3afgpunj	337	6	proteins	protein	NNS
cord-306921-3afgpunj	337	7	induce	induce	VBP
cord-306921-3afgpunj	337	8	autophagy	autophagy	NN
cord-306921-3afgpunj	337	9	through	through	IN
cord-306921-3afgpunj	337	10	localization	localization	NN
cord-306921-3afgpunj	337	11	with	with	IN
cord-306921-3afgpunj	337	12	LC3	LC3	NNP
cord-306921-3afgpunj	337	13	and	and	CC
cord-306921-3afgpunj	337	14	MPR	MPR	NNP
cord-306921-3afgpunj	337	15	Enhanced	Enhanced	NNP
cord-306921-3afgpunj	337	16	EV	EV	NNP
cord-306921-3afgpunj	337	17	-	-	HYPH
cord-306921-3afgpunj	337	18	A71	A71	NNP
cord-306921-3afgpunj	337	19	replication	replication	NN
cord-306921-3afgpunj	337	20	through	through	IN
cord-306921-3afgpunj	337	21	formation	formation	NN
cord-306921-3afgpunj	337	22	of	of	IN
cord-306921-3afgpunj	337	23	amphisome	amphisome	NNP
cord-306921-3afgpunj	337	24	[	[	-LRB-
cord-306921-3afgpunj	337	25	163	163	CD
cord-306921-3afgpunj	337	26	,	,	,
cord-306921-3afgpunj	337	27	164	164	CD
cord-306921-3afgpunj	337	28	]	]	-RRB-
cord-306921-3afgpunj	337	29	EV	EV	NNP
cord-306921-3afgpunj	337	30	-	-	HYPH
cord-306921-3afgpunj	337	31	A71	A71	NNP
cord-306921-3afgpunj	337	32	2	2	CD
cord-306921-3afgpunj	337	33	BC	BC	NNP
cord-306921-3afgpunj	337	34	protein	protein	NN
cord-306921-3afgpunj	337	35	interacts	interact	VBZ
cord-306921-3afgpunj	337	36	with	with	IN
cord-306921-3afgpunj	337	37	SNARE	snare	NN
cord-306921-3afgpunj	337	38	,	,	,
cord-306921-3afgpunj	337	39	STX17	STX17	NNP
cord-306921-3afgpunj	337	40	,	,	,
cord-306921-3afgpunj	337	41	SNAP29	SNAP29	NNP
cord-306921-3afgpunj	337	42	and	and	CC
cord-306921-3afgpunj	337	43	LC3B	lc3b	NN
cord-306921-3afgpunj	337	44	proteins	protein	NNS
cord-306921-3afgpunj	337	45	leading	lead	VBG
cord-306921-3afgpunj	337	46	to	to	IN
cord-306921-3afgpunj	337	47	formation	formation	NN
cord-306921-3afgpunj	337	48	of	of	IN
cord-306921-3afgpunj	337	49	autolysosome	autolysosome	NN
cord-306921-3afgpunj	337	50	in	in	IN
cord-306921-3afgpunj	337	51	RD	RD	NNP
cord-306921-3afgpunj	337	52	cells	cell	NNS
cord-306921-3afgpunj	338	1	Enhanced	enhanced	JJ
cord-306921-3afgpunj	338	2	viral	viral	JJ
cord-306921-3afgpunj	338	3	replication	replication	NN
cord-306921-3afgpunj	338	4	[	[	-LRB-
cord-306921-3afgpunj	338	5	165	165	CD
cord-306921-3afgpunj	338	6	]	]	-RRB-
cord-306921-3afgpunj	338	7	EV	EV	NNP
cord-306921-3afgpunj	338	8	-	-	HYPH
cord-306921-3afgpunj	338	9	D68	D68	NNP
cord-306921-3afgpunj	338	10	can	can	MD
cord-306921-3afgpunj	338	11	disrupt	disrupt	VB
cord-306921-3afgpunj	338	12	autophagy	autophagy	NN
cord-306921-3afgpunj	338	13	process	process	NN
cord-306921-3afgpunj	338	14	downstream	downstream	RB
cord-306921-3afgpunj	338	15	Promotes	promote	VBZ
cord-306921-3afgpunj	338	16	viral	viral	JJ
cord-306921-3afgpunj	338	17	replication	replication	NN
cord-306921-3afgpunj	338	18	and	and	CC
cord-306921-3afgpunj	338	19	egress	egress	NN
cord-306921-3afgpunj	338	20	from	from	IN
cord-306921-3afgpunj	338	21	infected	infected	JJ
cord-306921-3afgpunj	338	22	cells	cell	NNS
cord-306921-3afgpunj	338	23	;	;	:
cord-306921-3afgpunj	338	24	promoting	promote	VBG
cord-306921-3afgpunj	338	25	viral	viral	JJ
cord-306921-3afgpunj	338	26	infection	infection	NN
cord-306921-3afgpunj	338	27	within	within	IN
cord-306921-3afgpunj	338	28	the	the	DT
cord-306921-3afgpunj	338	29	cells	cell	NNS
cord-306921-3afgpunj	338	30	[	[	-LRB-
cord-306921-3afgpunj	338	31	166	166	CD
cord-306921-3afgpunj	338	32	]	]	-RRB-
cord-306921-3afgpunj	338	33	CV	cv	NN
cord-306921-3afgpunj	338	34	-	-	HYPH
cord-306921-3afgpunj	338	35	B3	b3	NN
cord-306921-3afgpunj	338	36	viral	viral	JJ
cord-306921-3afgpunj	338	37	protein	protein	NN
cord-306921-3afgpunj	338	38	3C	3C	NNP
cord-306921-3afgpunj	338	39	targets	target	VBZ
cord-306921-3afgpunj	338	40	cleavage	cleavage	NN
cord-306921-3afgpunj	338	41	of	of	IN
cord-306921-3afgpunj	338	42	SNARE	snare	NN
cord-306921-3afgpunj	338	43	and	and	CC
cord-306921-3afgpunj	338	44	PLEKHM1	plekhm1	NN
cord-306921-3afgpunj	338	45	proteins	protein	NNS
cord-306921-3afgpunj	338	46	Impairs	impair	VBZ
cord-306921-3afgpunj	338	47	establishment	establishment	NN
cord-306921-3afgpunj	338	48	of	of	IN
cord-306921-3afgpunj	338	49	SNARE	snare	NN
cord-306921-3afgpunj	338	50	complexes	complex	NNS
cord-306921-3afgpunj	338	51	thus	thus	RB
cord-306921-3afgpunj	338	52	providing	provide	VBG
cord-306921-3afgpunj	338	53	conducive	conducive	JJ
cord-306921-3afgpunj	338	54	environment	environment	NN
cord-306921-3afgpunj	338	55	for	for	IN
cord-306921-3afgpunj	338	56	viral	viral	JJ
cord-306921-3afgpunj	338	57	replication	replication	NN
cord-306921-3afgpunj	338	58	[	[	-LRB-
cord-306921-3afgpunj	338	59	170	170	CD
cord-306921-3afgpunj	338	60	]	]	-RRB-
cord-306921-3afgpunj	338	61	CV	cv	NN
cord-306921-3afgpunj	338	62	-	-	HYPH
cord-306921-3afgpunj	338	63	B3	b3	NN
cord-306921-3afgpunj	338	64	viral	viral	JJ
cord-306921-3afgpunj	338	65	2A	2a	CD
cord-306921-3afgpunj	338	66	protease	protease	NN
cord-306921-3afgpunj	338	67	cleaves	cleave	VBZ
cord-306921-3afgpunj	338	68	SQSTM1	SQSTM1	NNP
cord-306921-3afgpunj	338	69	/	/	SYM
cord-306921-3afgpunj	338	70	p62	p62	NN
cord-306921-3afgpunj	338	71	a	a	DT
cord-306921-3afgpunj	338	72	known	know	VBN
cord-306921-3afgpunj	338	73	intermediary	intermediary	NN
cord-306921-3afgpunj	338	74	of	of	IN
cord-306921-3afgpunj	338	75	selective	selective	JJ
cord-306921-3afgpunj	338	76	autophagy	autophagy	NN
cord-306921-3afgpunj	338	77	degradation	degradation	NN
cord-306921-3afgpunj	338	78	of	of	IN
cord-306921-3afgpunj	338	79	ubiquitinated	ubiquitinated	JJ
cord-306921-3afgpunj	338	80	proteins	protein	NNS
cord-306921-3afgpunj	338	81	Impairs	impair	VBZ
cord-306921-3afgpunj	339	1	NF	NF	NNP
cord-306921-3afgpunj	339	2	-	-	HYPH
cord-306921-3afgpunj	339	3	kB	kB	NNP
cord-306921-3afgpunj	339	4	signaling	signaling	NN
cord-306921-3afgpunj	339	5	and	and	CC
cord-306921-3afgpunj	339	6	disrupts	disrupt	VBZ
cord-306921-3afgpunj	339	7	selective	selective	JJ
cord-306921-3afgpunj	339	8	autophagy	autophagy	NN
cord-306921-3afgpunj	339	9	in	in	IN
cord-306921-3afgpunj	339	10	infected	infected	JJ
cord-306921-3afgpunj	339	11	cells	cell	NNS
cord-306921-3afgpunj	339	12	to	to	TO
cord-306921-3afgpunj	339	13	establish	establish	VB
cord-306921-3afgpunj	339	14	an	an	DT
cord-306921-3afgpunj	339	15	efficient	efficient	JJ
cord-306921-3afgpunj	339	16	viral	viral	JJ
cord-306921-3afgpunj	339	17	replication	replication	NN
cord-306921-3afgpunj	339	18	/	/	SYM
cord-306921-3afgpunj	339	19	infection	infection	NN
cord-306921-3afgpunj	339	20	[	[	-LRB-
cord-306921-3afgpunj	339	21	173	173	CD
cord-306921-3afgpunj	339	22	]	]	-RRB-
cord-306921-3afgpunj	339	23	CV	cv	NN
cord-306921-3afgpunj	339	24	-	-	HYPH
cord-306921-3afgpunj	339	25	B3	b3	NN
cord-306921-3afgpunj	339	26	interacts	interact	VBZ
cord-306921-3afgpunj	339	27	with	with	IN
cord-306921-3afgpunj	339	28	CALCOCO2	CALCOCO2	NNS
cord-306921-3afgpunj	339	29	and	and	CC
cord-306921-3afgpunj	339	30	SQSTM1	SQSTM1	NNP
cord-306921-3afgpunj	339	31	Targets	target	NNS
cord-306921-3afgpunj	339	32	autophagy	autophagy	NN
cord-306921-3afgpunj	339	33	receptors	receptor	NNS
cord-306921-3afgpunj	339	34	;	;	:
cord-306921-3afgpunj	339	35	targets	target	NNS
cord-306921-3afgpunj	339	36	mitochondrial	mitochondrial	JJ
cord-306921-3afgpunj	339	37	antiviral	antiviral	JJ
cord-306921-3afgpunj	339	38	signaling	signal	VBG
cord-306921-3afgpunj	339	39	protein	protein	NN
cord-306921-3afgpunj	339	40	for	for	IN
cord-306921-3afgpunj	339	41	degradation	degradation	NN
cord-306921-3afgpunj	339	42	thus	thus	RB
cord-306921-3afgpunj	339	43	blocking	block	VBG
cord-306921-3afgpunj	339	44	establishment	establishment	NN
cord-306921-3afgpunj	339	45	of	of	IN
cord-306921-3afgpunj	339	46	antiviral	antiviral	JJ
cord-306921-3afgpunj	339	47	state	state	NN
cord-306921-3afgpunj	339	48	in	in	IN
cord-306921-3afgpunj	339	49	the	the	DT
cord-306921-3afgpunj	339	50	infected	infected	JJ
cord-306921-3afgpunj	339	51	cells	cell	NNS
cord-306921-3afgpunj	339	52	[	[	-LRB-
cord-306921-3afgpunj	339	53	177	177	CD
cord-306921-3afgpunj	339	54	]	]	-RRB-
cord-306921-3afgpunj	339	55	targeting	target	VBG
cord-306921-3afgpunj	339	56	different	different	JJ
cord-306921-3afgpunj	339	57	stages	stage	NNS
cord-306921-3afgpunj	339	58	of	of	IN
cord-306921-3afgpunj	339	59	viral	viral	JJ
cord-306921-3afgpunj	339	60	infections	infection	NNS
cord-306921-3afgpunj	339	61	would	would	MD
cord-306921-3afgpunj	339	62	be	be	VB
cord-306921-3afgpunj	339	63	an	an	DT
cord-306921-3afgpunj	339	64	alternative	alternative	NN
cord-306921-3afgpunj	339	65	in	in	IN
cord-306921-3afgpunj	339	66	targeting	target	VBG
cord-306921-3afgpunj	339	67	different	different	JJ
cord-306921-3afgpunj	339	68	stages	stage	NNS
cord-306921-3afgpunj	339	69	of	of	IN
cord-306921-3afgpunj	339	70	the	the	DT
cord-306921-3afgpunj	339	71	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	339	72	infection	infection	NN
cord-306921-3afgpunj	339	73	cycle	cycle	NN
cord-306921-3afgpunj	339	74	.	.	.
cord-306921-3afgpunj	340	1	This	this	DT
cord-306921-3afgpunj	340	2	will	will	MD
cord-306921-3afgpunj	340	3	only	only	RB
cord-306921-3afgpunj	340	4	be	be	VB
cord-306921-3afgpunj	340	5	achieved	achieve	VBN
cord-306921-3afgpunj	340	6	with	with	IN
cord-306921-3afgpunj	340	7	a	a	DT
cord-306921-3afgpunj	340	8	complete	complete	JJ
cord-306921-3afgpunj	340	9	map	map	NN
cord-306921-3afgpunj	340	10	out	out	IN
cord-306921-3afgpunj	340	11	of	of	IN
cord-306921-3afgpunj	340	12	the	the	DT
cord-306921-3afgpunj	340	13	human	human	JJ
cord-306921-3afgpunj	340	14	host	host	NN
cord-306921-3afgpunj	340	15	factors	factor	NNS
cord-306921-3afgpunj	340	16	hijacked	hijack	VBN
cord-306921-3afgpunj	340	17	by	by	IN
cord-306921-3afgpunj	340	18	these	these	DT
cord-306921-3afgpunj	340	19	viruses	virus	NNS
cord-306921-3afgpunj	340	20	during	during	IN
cord-306921-3afgpunj	340	21	infections	infection	NNS
cord-306921-3afgpunj	340	22	.	.	.
cord-306921-3afgpunj	341	1	Thus	thus	RB
cord-306921-3afgpunj	341	2	,	,	,
cord-306921-3afgpunj	341	3	there	there	EX
cord-306921-3afgpunj	341	4	is	be	VBZ
cord-306921-3afgpunj	341	5	need	need	NN
cord-306921-3afgpunj	341	6	for	for	IN
cord-306921-3afgpunj	341	7	continued	continued	JJ
cord-306921-3afgpunj	341	8	elucidation	elucidation	NN
cord-306921-3afgpunj	341	9	of	of	IN
cord-306921-3afgpunj	341	10	molecular	molecular	JJ
cord-306921-3afgpunj	341	11	mechanisms	mechanism	NNS
cord-306921-3afgpunj	341	12	of	of	IN
cord-306921-3afgpunj	341	13	the	the	DT
cord-306921-3afgpunj	341	14	already	already	RB
cord-306921-3afgpunj	341	15	postulated	postulate	VBN
cord-306921-3afgpunj	341	16	viral	viral	JJ
cord-306921-3afgpunj	341	17	targets	target	NNS
cord-306921-3afgpunj	341	18	as	as	RB
cord-306921-3afgpunj	341	19	well	well	RB
cord-306921-3afgpunj	341	20	as	as	IN
cord-306921-3afgpunj	341	21	identifying	identify	VBG
cord-306921-3afgpunj	341	22	other	other	JJ
cord-306921-3afgpunj	341	23	underlying	underlying	JJ
cord-306921-3afgpunj	341	24	factors	factor	NNS
cord-306921-3afgpunj	341	25	and	and	CC
cord-306921-3afgpunj	341	26	process	process	NN
cord-306921-3afgpunj	341	27	.	.	.
cord-306921-3afgpunj	342	1	Vaccines	vaccine	NNS
cord-306921-3afgpunj	342	2	have	have	VBP
cord-306921-3afgpunj	342	3	shown	show	VBN
cord-306921-3afgpunj	342	4	much	much	JJ
cord-306921-3afgpunj	342	5	success	success	NN
cord-306921-3afgpunj	342	6	against	against	IN
cord-306921-3afgpunj	342	7	viral	viral	JJ
cord-306921-3afgpunj	342	8	infections	infection	NNS
cord-306921-3afgpunj	342	9	and	and	CC
cord-306921-3afgpunj	342	10	the	the	DT
cord-306921-3afgpunj	342	11	success	success	NN
cord-306921-3afgpunj	342	12	story	story	NN
cord-306921-3afgpunj	342	13	of	of	IN
cord-306921-3afgpunj	342	14	vaccination	vaccination	NN
cord-306921-3afgpunj	342	15	against	against	IN
cord-306921-3afgpunj	342	16	poliovirus	poliovirus	NN
cord-306921-3afgpunj	342	17	infection	infection	NN
cord-306921-3afgpunj	342	18	in	in	IN
cord-306921-3afgpunj	342	19	the	the	DT
cord-306921-3afgpunj	342	20	world	world	NN
cord-306921-3afgpunj	342	21	which	which	WDT
cord-306921-3afgpunj	342	22	is	be	VBZ
cord-306921-3afgpunj	342	23	a	a	DT
cord-306921-3afgpunj	342	24	picornavirus	picornavirus	NN
cord-306921-3afgpunj	342	25	;	;	:
cord-306921-3afgpunj	342	26	points	point	NNS
cord-306921-3afgpunj	342	27	for	for	IN
cord-306921-3afgpunj	342	28	the	the	DT
cord-306921-3afgpunj	342	29	need	need	NN
cord-306921-3afgpunj	342	30	of	of	IN
cord-306921-3afgpunj	342	31	continued	continue	VBN
cord-306921-3afgpunj	342	32	studies	study	NNS
cord-306921-3afgpunj	342	33	towards	towards	IN
cord-306921-3afgpunj	342	34	identifying	identify	VBG
cord-306921-3afgpunj	342	35	vaccine	vaccine	NN
cord-306921-3afgpunj	342	36	candidates	candidate	NNS
cord-306921-3afgpunj	342	37	against	against	IN
cord-306921-3afgpunj	342	38	the	the	DT
cord-306921-3afgpunj	342	39	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	342	40	infections	infection	NNS
cord-306921-3afgpunj	342	41	.	.	.
cord-306921-3afgpunj	343	1	With	with	IN
cord-306921-3afgpunj	343	2	outbreaks	outbreak	NNS
cord-306921-3afgpunj	343	3	of	of	IN
cord-306921-3afgpunj	343	4	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	343	5	being	be	VBG
cord-306921-3afgpunj	343	6	recorded	record	VBN
cord-306921-3afgpunj	343	7	in	in	IN
cord-306921-3afgpunj	343	8	different	different	JJ
cord-306921-3afgpunj	343	9	parts	part	NNS
cord-306921-3afgpunj	343	10	of	of	IN
cord-306921-3afgpunj	343	11	the	the	DT
cord-306921-3afgpunj	343	12	world	world	NN
cord-306921-3afgpunj	343	13	,	,	,
cord-306921-3afgpunj	343	14	if	if	IN
cord-306921-3afgpunj	343	15	not	not	RB
cord-306921-3afgpunj	343	16	checked	check	VBN
cord-306921-3afgpunj	343	17	they	-PRON-	PRP
cord-306921-3afgpunj	343	18	might	may	MD
cord-306921-3afgpunj	343	19	have	have	VB
cord-306921-3afgpunj	343	20	a	a	DT
cord-306921-3afgpunj	343	21	potential	potential	JJ
cord-306921-3afgpunj	343	22	threat	threat	NN
cord-306921-3afgpunj	343	23	to	to	IN
cord-306921-3afgpunj	343	24	the	the	DT
cord-306921-3afgpunj	343	25	global	global	JJ
cord-306921-3afgpunj	343	26	health	health	NN
cord-306921-3afgpunj	343	27	;	;	:
cord-306921-3afgpunj	343	28	just	just	RB
cord-306921-3afgpunj	343	29	soon	soon	RB
cord-306921-3afgpunj	343	30	after	after	IN
cord-306921-3afgpunj	343	31	near	near	JJ
cord-306921-3afgpunj	343	32	-	-	HYPH
cord-306921-3afgpunj	343	33	eradication	eradication	NN
cord-306921-3afgpunj	343	34	of	of	IN
cord-306921-3afgpunj	343	35	poliovirus	poliovirus	NN
cord-306921-3afgpunj	343	36	infection	infection	NN
cord-306921-3afgpunj	343	37	.	.	.
cord-306921-3afgpunj	344	1	The	the	DT
cord-306921-3afgpunj	344	2	emergence	emergence	NN
cord-306921-3afgpunj	344	3	of	of	IN
cord-306921-3afgpunj	344	4	outbreaks	outbreak	NNS
cord-306921-3afgpunj	344	5	of	of	IN
cord-306921-3afgpunj	344	6	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	344	7	infections	infection	NNS
cord-306921-3afgpunj	344	8	in	in	IN
cord-306921-3afgpunj	344	9	different	different	JJ
cord-306921-3afgpunj	344	10	parts	part	NNS
cord-306921-3afgpunj	344	11	of	of	IN
cord-306921-3afgpunj	344	12	the	the	DT
cord-306921-3afgpunj	344	13	world	world	NN
cord-306921-3afgpunj	344	14	point	point	NN
cord-306921-3afgpunj	344	15	to	to	IN
cord-306921-3afgpunj	344	16	the	the	DT
cord-306921-3afgpunj	344	17	need	need	NN
cord-306921-3afgpunj	344	18	of	of	IN
cord-306921-3afgpunj	344	19	mapping	mapping	NN
cord-306921-3afgpunj	344	20	all	all	PDT
cord-306921-3afgpunj	344	21	the	the	DT
cord-306921-3afgpunj	344	22	host	host	NN
cord-306921-3afgpunj	344	23	factors	factor	NNS
cord-306921-3afgpunj	344	24	involved	involve	VBN
cord-306921-3afgpunj	344	25	in	in	IN
cord-306921-3afgpunj	344	26	the	the	DT
cord-306921-3afgpunj	344	27	infection	infection	NN
cord-306921-3afgpunj	344	28	paradigm	paradigm	NN
cord-306921-3afgpunj	344	29	.	.	.
cord-306921-3afgpunj	345	1	Given	give	VBN
cord-306921-3afgpunj	345	2	that	that	IN
cord-306921-3afgpunj	345	3	viruses	virus	NNS
cord-306921-3afgpunj	345	4	need	need	VBP
cord-306921-3afgpunj	345	5	host	host	NN
cord-306921-3afgpunj	345	6	factors	factor	NNS
cord-306921-3afgpunj	345	7	in	in	IN
cord-306921-3afgpunj	345	8	every	every	DT
cord-306921-3afgpunj	345	9	step	step	NN
cord-306921-3afgpunj	345	10	of	of	IN
cord-306921-3afgpunj	345	11	their	-PRON-	PRP$
cord-306921-3afgpunj	345	12	infection	infection	NN
cord-306921-3afgpunj	345	13	from	from	IN
cord-306921-3afgpunj	345	14	attachment	attachment	NN
cord-306921-3afgpunj	345	15	,	,	,
cord-306921-3afgpunj	345	16	entry	entry	NN
cord-306921-3afgpunj	345	17	,	,	,
cord-306921-3afgpunj	345	18	replication	replication	NN
cord-306921-3afgpunj	345	19	,	,	,
cord-306921-3afgpunj	345	20	virion	virion	NN
cord-306921-3afgpunj	345	21	assembly	assembly	NN
cord-306921-3afgpunj	345	22	and	and	CC
cord-306921-3afgpunj	345	23	eventual	eventual	JJ
cord-306921-3afgpunj	345	24	entry	entry	NN
cord-306921-3afgpunj	345	25	,	,	,
cord-306921-3afgpunj	345	26	there	there	EX
cord-306921-3afgpunj	345	27	is	be	VBZ
cord-306921-3afgpunj	345	28	need	need	NN
cord-306921-3afgpunj	345	29	to	to	TO
cord-306921-3afgpunj	345	30	elucidate	elucidate	VB
cord-306921-3afgpunj	345	31	all	all	PDT
cord-306921-3afgpunj	345	32	the	the	DT
cord-306921-3afgpunj	345	33	host	host	NN
cord-306921-3afgpunj	345	34	factors	factor	NNS
cord-306921-3afgpunj	345	35	involved	involve	VBN
cord-306921-3afgpunj	345	36	for	for	IN
cord-306921-3afgpunj	345	37	an	an	DT
cord-306921-3afgpunj	345	38	improved	improved	JJ
cord-306921-3afgpunj	345	39	understanding	understanding	NN
cord-306921-3afgpunj	345	40	of	of	IN
cord-306921-3afgpunj	345	41	the	the	DT
cord-306921-3afgpunj	345	42	molecular	molecular	JJ
cord-306921-3afgpunj	345	43	dynamics	dynamic	NNS
cord-306921-3afgpunj	345	44	of	of	IN
cord-306921-3afgpunj	345	45	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	345	46	infections	infection	NNS
cord-306921-3afgpunj	345	47	.	.	.
cord-306921-3afgpunj	346	1	This	this	DT
cord-306921-3afgpunj	346	2	will	will	MD
cord-306921-3afgpunj	346	3	be	be	VB
cord-306921-3afgpunj	346	4	a	a	DT
cord-306921-3afgpunj	346	5	big	big	JJ
cord-306921-3afgpunj	346	6	boost	boost	NN
cord-306921-3afgpunj	346	7	towards	towards	IN
cord-306921-3afgpunj	346	8	the	the	DT
cord-306921-3afgpunj	346	9	long	long	JJ
cord-306921-3afgpunj	346	10	overdue	overdue	JJ
cord-306921-3afgpunj	346	11	antiviral	antiviral	JJ
cord-306921-3afgpunj	346	12	and	and	CC
cord-306921-3afgpunj	346	13	vaccine	vaccine	NN
cord-306921-3afgpunj	346	14	development	development	NN
cord-306921-3afgpunj	346	15	against	against	IN
cord-306921-3afgpunj	346	16	these	these	DT
cord-306921-3afgpunj	346	17	epidemiologically	epidemiologically	RB
cord-306921-3afgpunj	346	18	important	important	JJ
cord-306921-3afgpunj	346	19	viruses	virus	NNS
cord-306921-3afgpunj	346	20	.	.	.
cord-306921-3afgpunj	347	1	There	there	EX
cord-306921-3afgpunj	347	2	is	be	VBZ
cord-306921-3afgpunj	347	3	much	much	JJ
cord-306921-3afgpunj	347	4	to	to	TO
cord-306921-3afgpunj	347	5	be	be	VB
cord-306921-3afgpunj	347	6	elucidated	elucidate	VBN
cord-306921-3afgpunj	347	7	on	on	IN
cord-306921-3afgpunj	347	8	the	the	DT
cord-306921-3afgpunj	347	9	formation	formation	NN
cord-306921-3afgpunj	347	10	of	of	IN
cord-306921-3afgpunj	347	11	NPEV	NPEV	NNP
cord-306921-3afgpunj	347	12	replication	replication	NN
cord-306921-3afgpunj	347	13	complex	complex	JJ
cord-306921-3afgpunj	347	14	formation	formation	NN
cord-306921-3afgpunj	347	15	as	as	IN
cord-306921-3afgpunj	347	16	the	the	DT
cord-306921-3afgpunj	347	17	existing	exist	VBG
cord-306921-3afgpunj	347	18	mechanisms	mechanism	NNS
cord-306921-3afgpunj	347	19	do	do	VBP
cord-306921-3afgpunj	347	20	not	not	RB
cord-306921-3afgpunj	347	21	wholly	wholly	RB
cord-306921-3afgpunj	347	22	explain	explain	VB
cord-306921-3afgpunj	347	23	the	the	DT
cord-306921-3afgpunj	347	24	processes	process	NNS
cord-306921-3afgpunj	347	25	and	and	CC
cord-306921-3afgpunj	347	26	steps	step	NNS
cord-306921-3afgpunj	347	27	involved	involve	VBN
cord-306921-3afgpunj	347	28	in	in	IN
cord-306921-3afgpunj	347	29	this	this	DT
cord-306921-3afgpunj	347	30	important	important	JJ
cord-306921-3afgpunj	347	31	process	process	NN
cord-306921-3afgpunj	347	32	during	during	IN
cord-306921-3afgpunj	347	33	viral	viral	JJ
cord-306921-3afgpunj	347	34	replication	replication	NN
cord-306921-3afgpunj	347	35	.	.	.
cord-306921-3afgpunj	348	1	The	the	DT
cord-306921-3afgpunj	348	2	nuclear	nuclear	JJ
cord-306921-3afgpunj	348	3	host	host	NN
cord-306921-3afgpunj	348	4	factors	factor	NNS
cord-306921-3afgpunj	348	5	involved	involve	VBN
cord-306921-3afgpunj	348	6	in	in	IN
cord-306921-3afgpunj	348	7	the	the	DT
cord-306921-3afgpunj	348	8	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	348	9	replication	replication	NN
cord-306921-3afgpunj	348	10	also	also	RB
cord-306921-3afgpunj	348	11	needs	need	VBZ
cord-306921-3afgpunj	348	12	to	to	TO
cord-306921-3afgpunj	348	13	be	be	VB
cord-306921-3afgpunj	348	14	fully	fully	RB
cord-306921-3afgpunj	348	15	described	describe	VBN
cord-306921-3afgpunj	348	16	as	as	IN
cord-306921-3afgpunj	348	17	this	this	DT
cord-306921-3afgpunj	348	18	is	be	VBZ
cord-306921-3afgpunj	348	19	a	a	DT
cord-306921-3afgpunj	348	20	vital	vital	JJ
cord-306921-3afgpunj	348	21	step	step	NN
cord-306921-3afgpunj	348	22	in	in	IN
cord-306921-3afgpunj	348	23	maintaining	maintain	VBG
cord-306921-3afgpunj	348	24	viral	viral	JJ
cord-306921-3afgpunj	348	25	replication	replication	NN
cord-306921-3afgpunj	348	26	and	and	CC
cord-306921-3afgpunj	348	27	eventual	eventual	JJ
cord-306921-3afgpunj	348	28	life	life	NN
cord-306921-3afgpunj	348	29	cycle	cycle	NN
cord-306921-3afgpunj	348	30	.	.	.
cord-306921-3afgpunj	349	1	Viral	viral	JJ
cord-306921-3afgpunj	349	2	entry	entry	NN
cord-306921-3afgpunj	349	3	studies	study	NNS
cord-306921-3afgpunj	349	4	need	need	VBP
cord-306921-3afgpunj	349	5	to	to	TO
cord-306921-3afgpunj	349	6	be	be	VB
cord-306921-3afgpunj	349	7	carried	carry	VBN
cord-306921-3afgpunj	349	8	out	out	RP
cord-306921-3afgpunj	349	9	as	as	IN
cord-306921-3afgpunj	349	10	the	the	DT
cord-306921-3afgpunj	349	11	known	know	VBN
cord-306921-3afgpunj	349	12	receptors	receptor	NNS
cord-306921-3afgpunj	349	13	and	and	CC
cord-306921-3afgpunj	349	14	viral	viral	JJ
cord-306921-3afgpunj	349	15	entry	entry	NN
cord-306921-3afgpunj	349	16	requirements	requirement	NNS
cord-306921-3afgpunj	349	17	do	do	VBP
cord-306921-3afgpunj	349	18	not	not	RB
cord-306921-3afgpunj	349	19	fully	fully	RB
cord-306921-3afgpunj	349	20	explain	explain	VB
cord-306921-3afgpunj	349	21	the	the	DT
cord-306921-3afgpunj	349	22	myriad	myriad	NN
cord-306921-3afgpunj	349	23	of	of	IN
cord-306921-3afgpunj	349	24	disease	disease	NN
cord-306921-3afgpunj	349	25	features	feature	NNS
cord-306921-3afgpunj	349	26	observed	observe	VBN
cord-306921-3afgpunj	349	27	during	during	IN
cord-306921-3afgpunj	349	28	viral	viral	JJ
cord-306921-3afgpunj	349	29	infections	infection	NNS
cord-306921-3afgpunj	349	30	.	.	.
cord-306921-3afgpunj	350	1	The	the	DT
cord-306921-3afgpunj	350	2	role	role	NN
cord-306921-3afgpunj	350	3	of	of	IN
cord-306921-3afgpunj	350	4	cellular	cellular	JJ
cord-306921-3afgpunj	350	5	processes	process	NNS
cord-306921-3afgpunj	350	6	such	such	JJ
cord-306921-3afgpunj	350	7	as	as	IN
cord-306921-3afgpunj	350	8	autophagy	autophagy	NN
cord-306921-3afgpunj	350	9	,	,	,
cord-306921-3afgpunj	350	10	apoptosis	apoptosis	NN
cord-306921-3afgpunj	350	11	,	,	,
cord-306921-3afgpunj	350	12	necroptosis	necroptosis	NNP
cord-306921-3afgpunj	350	13	,	,	,
cord-306921-3afgpunj	350	14	pyroptosis	pyroptosis	NNP
cord-306921-3afgpunj	350	15	as	as	RB
cord-306921-3afgpunj	350	16	well	well	RB
cord-306921-3afgpunj	350	17	as	as	IN
cord-306921-3afgpunj	350	18	posttranslational	posttranslational	JJ
cord-306921-3afgpunj	350	19	modifications	modification	NNS
cord-306921-3afgpunj	350	20	in	in	IN
cord-306921-3afgpunj	350	21	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	350	22	infections	infection	NNS
cord-306921-3afgpunj	350	23	also	also	RB
cord-306921-3afgpunj	350	24	needs	need	VBZ
cord-306921-3afgpunj	350	25	to	to	TO
cord-306921-3afgpunj	350	26	be	be	VB
cord-306921-3afgpunj	350	27	fully	fully	RB
cord-306921-3afgpunj	350	28	elucidated	elucidate	VBN
cord-306921-3afgpunj	350	29	.	.	.
cord-306921-3afgpunj	351	1	This	this	DT
cord-306921-3afgpunj	351	2	will	will	MD
cord-306921-3afgpunj	351	3	be	be	VB
cord-306921-3afgpunj	351	4	specifically	specifically	RB
cord-306921-3afgpunj	351	5	important	important	JJ
cord-306921-3afgpunj	351	6	in	in	IN
cord-306921-3afgpunj	351	7	explaining	explain	VBG
cord-306921-3afgpunj	351	8	the	the	DT
cord-306921-3afgpunj	351	9	little	little	RB
cord-306921-3afgpunj	351	10	-	-	HYPH
cord-306921-3afgpunj	351	11	known	know	VBN
cord-306921-3afgpunj	351	12	stages	stage	NNS
cord-306921-3afgpunj	351	13	of	of	IN
cord-306921-3afgpunj	351	14	viral	viral	JJ
cord-306921-3afgpunj	351	15	infections	infection	NNS
cord-306921-3afgpunj	351	16	such	such	JJ
cord-306921-3afgpunj	351	17	as	as	IN
cord-306921-3afgpunj	351	18	non	non	JJ
cord-306921-3afgpunj	351	19	-	-	JJ
cord-306921-3afgpunj	351	20	lytic	lytic	JJ
cord-306921-3afgpunj	351	21	egress	egress	NN
cord-306921-3afgpunj	351	22	for	for	IN
cord-306921-3afgpunj	351	23	continuous	continuous	JJ
cord-306921-3afgpunj	351	24	viral	viral	JJ
cord-306921-3afgpunj	351	25	cycle	cycle	NN
cord-306921-3afgpunj	351	26	within	within	IN
cord-306921-3afgpunj	351	27	the	the	DT
cord-306921-3afgpunj	351	28	host	host	NN
cord-306921-3afgpunj	351	29	.	.	.
cord-306921-3afgpunj	352	1	The	the	DT
cord-306921-3afgpunj	352	2	paucity	paucity	NN
cord-306921-3afgpunj	352	3	of	of	IN
cord-306921-3afgpunj	352	4	information	information	NN
cord-306921-3afgpunj	352	5	on	on	IN
cord-306921-3afgpunj	352	6	the	the	DT
cord-306921-3afgpunj	352	7	infection	infection	NN
cord-306921-3afgpunj	352	8	dynamics	dynamic	NNS
cord-306921-3afgpunj	352	9	of	of	IN
cord-306921-3afgpunj	352	10	these	these	DT
cord-306921-3afgpunj	352	11	viruses	virus	NNS
cord-306921-3afgpunj	352	12	calls	call	VBZ
cord-306921-3afgpunj	352	13	for	for	IN
cord-306921-3afgpunj	352	14	concerted	concerted	JJ
cord-306921-3afgpunj	352	15	efforts	effort	NNS
cord-306921-3afgpunj	352	16	to	to	TO
cord-306921-3afgpunj	352	17	elucidate	elucidate	VB
cord-306921-3afgpunj	352	18	the	the	DT
cord-306921-3afgpunj	352	19	viral	viral	JJ
cord-306921-3afgpunj	352	20	-	-	HYPH
cord-306921-3afgpunj	352	21	human	human	JJ
cord-306921-3afgpunj	352	22	cell	cell	NN
cord-306921-3afgpunj	352	23	interactions	interaction	NNS
cord-306921-3afgpunj	352	24	.	.	.
cord-306921-3afgpunj	353	1	There	there	EX
cord-306921-3afgpunj	353	2	is	be	VBZ
cord-306921-3afgpunj	353	3	still	still	RB
cord-306921-3afgpunj	353	4	a	a	DT
cord-306921-3afgpunj	353	5	lot	lot	NN
cord-306921-3afgpunj	353	6	to	to	TO
cord-306921-3afgpunj	353	7	be	be	VB
cord-306921-3afgpunj	353	8	investigated	investigate	VBN
cord-306921-3afgpunj	353	9	to	to	TO
cord-306921-3afgpunj	353	10	fill	fill	VB
cord-306921-3afgpunj	353	11	the	the	DT
cord-306921-3afgpunj	353	12	gaps	gap	NNS
cord-306921-3afgpunj	353	13	that	that	WDT
cord-306921-3afgpunj	353	14	exist	exist	VBP
cord-306921-3afgpunj	353	15	on	on	IN
cord-306921-3afgpunj	353	16	the	the	DT
cord-306921-3afgpunj	353	17	life	life	NN
cord-306921-3afgpunj	353	18	cycle	cycle	NN
cord-306921-3afgpunj	353	19	of	of	IN
cord-306921-3afgpunj	353	20	non	non	JJ
cord-306921-3afgpunj	353	21	-	-	JJ
cord-306921-3afgpunj	353	22	polio	polio	JJ
cord-306921-3afgpunj	353	23	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	353	24	.	.	.
cord-306921-3afgpunj	354	1	With	with	IN
cord-306921-3afgpunj	354	2	new	new	JJ
cord-306921-3afgpunj	354	3	cases	case	NNS
cord-306921-3afgpunj	354	4	emerging	emerge	VBG
cord-306921-3afgpunj	354	5	in	in	IN
cord-306921-3afgpunj	354	6	different	different	JJ
cord-306921-3afgpunj	354	7	parts	part	NNS
cord-306921-3afgpunj	354	8	of	of	IN
cord-306921-3afgpunj	354	9	the	the	DT
cord-306921-3afgpunj	354	10	world	world	NN
cord-306921-3afgpunj	354	11	,	,	,
cord-306921-3afgpunj	354	12	it	-PRON-	PRP
cord-306921-3afgpunj	354	13	is	be	VBZ
cord-306921-3afgpunj	354	14	just	just	RB
cord-306921-3afgpunj	354	15	a	a	DT
cord-306921-3afgpunj	354	16	matter	matter	NN
cord-306921-3afgpunj	354	17	of	of	IN
cord-306921-3afgpunj	354	18	time	time	NN
cord-306921-3afgpunj	354	19	before	before	IN
cord-306921-3afgpunj	354	20	we	-PRON-	PRP
cord-306921-3afgpunj	354	21	have	have	VBP
cord-306921-3afgpunj	354	22	a	a	DT
cord-306921-3afgpunj	354	23	global	global	JJ
cord-306921-3afgpunj	354	24	outbreak	outbreak	NN
cord-306921-3afgpunj	354	25	of	of	IN
cord-306921-3afgpunj	354	26	non	non	JJ
cord-306921-3afgpunj	354	27	-	-	JJ
cord-306921-3afgpunj	354	28	poliovirus	poliovirus	JJ
cord-306921-3afgpunj	354	29	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	354	30	infections	infection	NNS
cord-306921-3afgpunj	354	31	in	in	IN
cord-306921-3afgpunj	354	32	different	different	JJ
cord-306921-3afgpunj	354	33	parts	part	NNS
cord-306921-3afgpunj	354	34	of	of	IN
cord-306921-3afgpunj	354	35	the	the	DT
cord-306921-3afgpunj	354	36	world	world	NN
cord-306921-3afgpunj	354	37	.	.	.
cord-306921-3afgpunj	355	1	There	there	EX
cord-306921-3afgpunj	355	2	is	be	VBZ
cord-306921-3afgpunj	355	3	also	also	RB
cord-306921-3afgpunj	355	4	an	an	DT
cord-306921-3afgpunj	355	5	urgent	urgent	JJ
cord-306921-3afgpunj	355	6	need	need	NN
cord-306921-3afgpunj	355	7	for	for	IN
cord-306921-3afgpunj	355	8	further	further	JJ
cord-306921-3afgpunj	355	9	studies	study	NNS
cord-306921-3afgpunj	355	10	especially	especially	RB
cord-306921-3afgpunj	355	11	in	in	IN
cord-306921-3afgpunj	355	12	the	the	DT
cord-306921-3afgpunj	355	13	field	field	NN
cord-306921-3afgpunj	355	14	of	of	IN
cord-306921-3afgpunj	355	15	vaccine	vaccine	NN
cord-306921-3afgpunj	355	16	developments	development	NNS
cord-306921-3afgpunj	355	17	as	as	RB
cord-306921-3afgpunj	355	18	well	well	RB
cord-306921-3afgpunj	355	19	as	as	IN
cord-306921-3afgpunj	355	20	antiviral	antiviral	JJ
cord-306921-3afgpunj	355	21	therapy	therapy	NN
cord-306921-3afgpunj	355	22	against	against	IN
cord-306921-3afgpunj	355	23	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	355	24	.	.	.
cord-306921-3afgpunj	356	1	We	-PRON-	PRP
cord-306921-3afgpunj	356	2	would	would	MD
cord-306921-3afgpunj	356	3	like	like	VB
cord-306921-3afgpunj	356	4	to	to	TO
cord-306921-3afgpunj	356	5	thank	thank	VB
cord-306921-3afgpunj	356	6	the	the	DT
cord-306921-3afgpunj	356	7	authors	author	NNS
cord-306921-3afgpunj	356	8	'	'	POS
cord-306921-3afgpunj	356	9	whose	whose	WP$
cord-306921-3afgpunj	356	10	work	work	NN
cord-306921-3afgpunj	356	11	has	have	VBZ
cord-306921-3afgpunj	356	12	been	be	VBN
cord-306921-3afgpunj	356	13	reviewed	review	VBN
cord-306921-3afgpunj	356	14	and	and	CC
cord-306921-3afgpunj	356	15	cited	cite	VBN
cord-306921-3afgpunj	356	16	in	in	IN
cord-306921-3afgpunj	356	17	this	this	DT
cord-306921-3afgpunj	356	18	paper	paper	NN
cord-306921-3afgpunj	356	19	as	as	RB
cord-306921-3afgpunj	356	20	well	well	RB
cord-306921-3afgpunj	356	21	the	the	DT
cord-306921-3afgpunj	356	22	funding	funding	NN
cord-306921-3afgpunj	356	23	organizations	organization	NNS
cord-306921-3afgpunj	356	24	that	that	WDT
cord-306921-3afgpunj	356	25	funded	fund	VBD
cord-306921-3afgpunj	356	26	the	the	DT
cord-306921-3afgpunj	356	27	primary	primary	JJ
cord-306921-3afgpunj	356	28	research	research	NN
cord-306921-3afgpunj	356	29	.	.	.
cord-306921-3afgpunj	357	1	Authors	author	NNS
cord-306921-3afgpunj	357	2	'	'	POS
cord-306921-3afgpunj	357	3	contributions	contribution	NNS
cord-306921-3afgpunj	357	4	COO	COO	NNP
cord-306921-3afgpunj	357	5	conducted	conduct	VBD
cord-306921-3afgpunj	357	6	literature	literature	NN
cord-306921-3afgpunj	357	7	research	research	NN
cord-306921-3afgpunj	357	8	and	and	CC
cord-306921-3afgpunj	357	9	wrote	write	VBD
cord-306921-3afgpunj	357	10	the	the	DT
cord-306921-3afgpunj	357	11	draft	draft	NN
cord-306921-3afgpunj	357	12	manuscript	manuscript	NN
cord-306921-3afgpunj	357	13	,	,	,
cord-306921-3afgpunj	357	14	JC	JC	NNP
cord-306921-3afgpunj	357	15	provided	provide	VBD
cord-306921-3afgpunj	357	16	editorial	editorial	JJ
cord-306921-3afgpunj	357	17	input	input	NN
cord-306921-3afgpunj	357	18	and	and	CC
cord-306921-3afgpunj	357	19	revision	revision	NN
cord-306921-3afgpunj	357	20	for	for	IN
cord-306921-3afgpunj	357	21	the	the	DT
cord-306921-3afgpunj	357	22	final	final	JJ
cord-306921-3afgpunj	357	23	version	version	NN
cord-306921-3afgpunj	357	24	.	.	.
cord-306921-3afgpunj	358	1	Both	both	DT
cord-306921-3afgpunj	358	2	authors	author	NNS
cord-306921-3afgpunj	358	3	read	read	VBP
cord-306921-3afgpunj	358	4	and	and	CC
cord-306921-3afgpunj	358	5	approved	approve	VBD
cord-306921-3afgpunj	358	6	the	the	DT
cord-306921-3afgpunj	358	7	final	final	JJ
cord-306921-3afgpunj	358	8	manuscript	manuscript	NN
cord-306921-3afgpunj	358	9	.	.	.
cord-306921-3afgpunj	359	1	Agency	Agency	NNP
cord-306921-3afgpunj	359	2	for	for	IN
cord-306921-3afgpunj	359	3	Science	Science	NNP
cord-306921-3afgpunj	359	4	,	,	,
cord-306921-3afgpunj	359	5	Technology	Technology	NNP
cord-306921-3afgpunj	359	6	and	and	CC
cord-306921-3afgpunj	359	7	Research	Research	NNP
cord-306921-3afgpunj	359	8	-	-	HYPH
cord-306921-3afgpunj	359	9	Singapore	Singapore	NNP
cord-306921-3afgpunj	359	10	International	International	NNP
cord-306921-3afgpunj	359	11	Graduate	Graduate	NNP
cord-306921-3afgpunj	359	12	Award	Award	NNP
cord-306921-3afgpunj	359	13	(	(	-LRB-
cord-306921-3afgpunj	359	14	A*STAR	A*STAR	NNP
cord-306921-3afgpunj	359	15	-	-	HYPH
cord-306921-3afgpunj	359	16	SINGA	SINGA	NNP
cord-306921-3afgpunj	359	17	)	)	-RRB-
cord-306921-3afgpunj	359	18	.	.	.
cord-306921-3afgpunj	360	1	Some	some	DT
cord-306921-3afgpunj	360	2	of	of	IN
cord-306921-3afgpunj	360	3	the	the	DT
cord-306921-3afgpunj	360	4	work	work	NN
cord-306921-3afgpunj	360	5	reviewed	review	VBN
cord-306921-3afgpunj	360	6	and	and	CC
cord-306921-3afgpunj	360	7	cited	cite	VBN
cord-306921-3afgpunj	360	8	in	in	IN
cord-306921-3afgpunj	360	9	this	this	DT
cord-306921-3afgpunj	360	10	paper	paper	NN
cord-306921-3afgpunj	360	11	was	be	VBD
cord-306921-3afgpunj	360	12	funded	fund	VBN
cord-306921-3afgpunj	360	13	by	by	IN
cord-306921-3afgpunj	360	14	different	different	JJ
cord-306921-3afgpunj	360	15	funding	funding	NN
cord-306921-3afgpunj	360	16	agencies	agency	NNS
cord-306921-3afgpunj	360	17	.	.	.
cord-306921-3afgpunj	361	1	Availability	availability	NN
cord-306921-3afgpunj	361	2	of	of	IN
cord-306921-3afgpunj	361	3	data	datum	NNS
cord-306921-3afgpunj	361	4	and	and	CC
cord-306921-3afgpunj	361	5	materials	material	NNS
cord-306921-3afgpunj	361	6	Not	not	RB
cord-306921-3afgpunj	361	7	applicable	applicable	JJ
cord-306921-3afgpunj	361	8	.	.	.
cord-306921-3afgpunj	362	1	DTriP	DTriP	NNP
cord-306921-3afgpunj	362	2	EV	EV	NNP
cord-306921-3afgpunj	362	3	-	-	HYPH
cord-306921-3afgpunj	362	4	A71	A71	NNP
cord-306921-3afgpunj	362	5	Blocks	Blocks	NNP
cord-306921-3afgpunj	362	6	viral	viral	JJ
cord-306921-3afgpunj	362	7	replication	replication	NN
cord-306921-3afgpunj	362	8	by	by	IN
cord-306921-3afgpunj	362	9	targeting	target	VBG
cord-306921-3afgpunj	362	10	the	the	DT
cord-306921-3afgpunj	362	11	RNA	RNA	NNP
cord-306921-3afgpunj	362	12	dependent	dependent	JJ
cord-306921-3afgpunj	362	13	RNA	RNA	NNP
cord-306921-3afgpunj	362	14	polymerase	polymerase	NN
cord-306921-3afgpunj	362	15	.	.	.
cord-306921-3afgpunj	363	1	[	[	-LRB-
cord-306921-3afgpunj	363	2	195	195	CD
cord-306921-3afgpunj	363	3	]	]	-RRB-
cord-306921-3afgpunj	364	1	Ribavirin	Ribavirin	NNP
cord-306921-3afgpunj	364	2	EV	EV	NNP
cord-306921-3afgpunj	364	3	-	-	HYPH
cord-306921-3afgpunj	364	4	A71	A71	NNP
cord-306921-3afgpunj	364	5	General	General	NNP
cord-306921-3afgpunj	364	6	reduction	reduction	NN
cord-306921-3afgpunj	364	7	of	of	IN
cord-306921-3afgpunj	364	8	the	the	DT
cord-306921-3afgpunj	364	9	viral	viral	JJ
cord-306921-3afgpunj	364	10	yield	yield	NN
cord-306921-3afgpunj	364	11	[	[	-LRB-
cord-306921-3afgpunj	364	12	179	179	CD
cord-306921-3afgpunj	364	13	]	]	-RRB-
cord-306921-3afgpunj	365	1	Quercetin	Quercetin	NNP
cord-306921-3afgpunj	365	2	EV	EV	NNP
cord-306921-3afgpunj	365	3	-	-	HYPH
cord-306921-3afgpunj	365	4	A71	A71	NNP
cord-306921-3afgpunj	365	5	Inhibits	inhibit	VBZ
cord-306921-3afgpunj	365	6	virus	virus	NN
cord-306921-3afgpunj	365	7	attachment	attachment	NN
cord-306921-3afgpunj	365	8	,	,	,
cord-306921-3afgpunj	365	9	adsorption	adsorption	NN
cord-306921-3afgpunj	365	10	and	and	CC
cord-306921-3afgpunj	365	11	the	the	DT
cord-306921-3afgpunj	365	12	viral	viral	JJ
cord-306921-3afgpunj	365	13	3C	3c	NN
cord-306921-3afgpunj	365	14	protease	protease	NN
cord-306921-3afgpunj	365	15	[	[	-LRB-
cord-306921-3afgpunj	365	16	180	180	CD
cord-306921-3afgpunj	365	17	]	]	-RRB-
cord-306921-3afgpunj	366	1	Rupintrivir	Rupintrivir	NNP
cord-306921-3afgpunj	366	2	EV	EV	NNP
cord-306921-3afgpunj	366	3	-	-	HYPH
cord-306921-3afgpunj	366	4	A71	A71	NNP
cord-306921-3afgpunj	366	5	,	,	,
cord-306921-3afgpunj	366	6	CV	CV	NNP
cord-306921-3afgpunj	366	7	-	-	HYPH
cord-306921-3afgpunj	366	8	A16	A16	NNP
cord-306921-3afgpunj	366	9	,	,	,
cord-306921-3afgpunj	366	10	HRV	HRV	NNP
cord-306921-3afgpunj	366	11	Binds	bind	VBZ
cord-306921-3afgpunj	366	12	and	and	CC
cord-306921-3afgpunj	366	13	inhibits	inhibit	VBZ
cord-306921-3afgpunj	366	14	viral	viral	JJ
cord-306921-3afgpunj	366	15	3C	3c	NN
cord-306921-3afgpunj	366	16	protease	protease	NN
cord-306921-3afgpunj	366	17	activity	activity	NN
cord-306921-3afgpunj	366	18	[	[	-LRB-
cord-306921-3afgpunj	366	19	196	196	CD
cord-306921-3afgpunj	366	20	]	]	-RRB-
cord-306921-3afgpunj	367	1	[	[	-LRB-
cord-306921-3afgpunj	367	2	197	197	CD
cord-306921-3afgpunj	367	3	]	]	-RRB-
cord-306921-3afgpunj	368	1	[	[	-LRB-
cord-306921-3afgpunj	368	2	198	198	CD
cord-306921-3afgpunj	368	3	]	]	-RRB-
cord-306921-3afgpunj	369	1	Fluoxetine	Fluoxetine	NNP
cord-306921-3afgpunj	369	2	CV	CV	NNP
cord-306921-3afgpunj	369	3	-	-	HYPH
cord-306921-3afgpunj	369	4	B3	B3	NNP
cord-306921-3afgpunj	369	5	Reduces	reduce	VBZ
cord-306921-3afgpunj	369	6	synthesis	synthesis	NN
cord-306921-3afgpunj	369	7	of	of	IN
cord-306921-3afgpunj	369	8	viral	viral	JJ
cord-306921-3afgpunj	369	9	RNA	RNA	NNP
cord-306921-3afgpunj	369	10	and	and	CC
cord-306921-3afgpunj	369	11	protein	protein	NN
cord-306921-3afgpunj	369	12	[	[	-LRB-
cord-306921-3afgpunj	369	13	199	199	CD
cord-306921-3afgpunj	369	14	]	]	-RRB-
cord-306921-3afgpunj	370	1	Dibucaine	Dibucaine	NNP
cord-306921-3afgpunj	370	2	CV	cv	NN
cord-306921-3afgpunj	370	3	-	-	HYPH
cord-306921-3afgpunj	370	4	B3	b3	NN
cord-306921-3afgpunj	370	5	,	,	,
cord-306921-3afgpunj	370	6	EV	EV	NNP
cord-306921-3afgpunj	370	7	-	-	HYPH
cord-306921-3afgpunj	370	8	D68	D68	NNP
cord-306921-3afgpunj	370	9	,	,	,
cord-306921-3afgpunj	370	10	RNA	RNA	NNP
cord-306921-3afgpunj	370	11	replication	replication	NN
cord-306921-3afgpunj	370	12	stage	stage	NN
cord-306921-3afgpunj	370	13	;	;	:
cord-306921-3afgpunj	370	14	may	may	MD
cord-306921-3afgpunj	370	15	be	be	VB
cord-306921-3afgpunj	370	16	targeting	target	VBG
cord-306921-3afgpunj	370	17	CV	cv	NN
cord-306921-3afgpunj	370	18	-	-	HYPH
cord-306921-3afgpunj	370	19	B3	B3	NNP
cord-306921-3afgpunj	370	20	viral	viral	JJ
cord-306921-3afgpunj	370	21	2C	2c	NN
cord-306921-3afgpunj	370	22	protease	protease	NN
cord-306921-3afgpunj	370	23	[	[	-LRB-
cord-306921-3afgpunj	370	24	184	184	CD
cord-306921-3afgpunj	370	25	]	]	-RRB-
cord-306921-3afgpunj	370	26	Formoterol	Formoterol	NNP
cord-306921-3afgpunj	370	27	CV	CV	NNP
cord-306921-3afgpunj	370	28	-	-	HYPH
cord-306921-3afgpunj	370	29	B3	B3	NNP
cord-306921-3afgpunj	370	30	,	,	,
cord-306921-3afgpunj	370	31	EV	EV	NNP
cord-306921-3afgpunj	370	32	-	-	HYPH
cord-306921-3afgpunj	370	33	D68	D68	NNP
cord-306921-3afgpunj	370	34	,	,	,
cord-306921-3afgpunj	370	35	EV	EV	NNP
cord-306921-3afgpunj	370	36	-	-	HYPH
cord-306921-3afgpunj	370	37	A71	A71	NNP
cord-306921-3afgpunj	370	38	,	,	,
cord-306921-3afgpunj	370	39	RV	RV	NNP
cord-306921-3afgpunj	370	40	-	-	HYPH
cord-306921-3afgpunj	370	41	A2	A2	NNP
cord-306921-3afgpunj	370	42	,	,	,
cord-306921-3afgpunj	371	1	RV	rv	NN
cord-306921-3afgpunj	371	2	-	-	HYPH
cord-306921-3afgpunj	371	3	B14	B14	NNP
cord-306921-3afgpunj	371	4	Likely	likely	RB
cord-306921-3afgpunj	371	5	inhibit	inhibit	VBP
cord-306921-3afgpunj	371	6	RV-14	RV-14	NNP
cord-306921-3afgpunj	371	7	by	by	IN
cord-306921-3afgpunj	371	8	reducing	reduce	VBG
cord-306921-3afgpunj	371	9	ICAM-1	icam-1	NN
cord-306921-3afgpunj	371	10	levels	level	NNS
cord-306921-3afgpunj	371	11	or	or	CC
cord-306921-3afgpunj	371	12	acidic	acidic	JJ
cord-306921-3afgpunj	371	13	endosomes	endosome	NNS
cord-306921-3afgpunj	371	14	.	.	.
cord-306921-3afgpunj	372	1	[	[	-LRB-
cord-306921-3afgpunj	372	2	184	184	CD
cord-306921-3afgpunj	372	3	,	,	,
cord-306921-3afgpunj	372	4	200	200	CD
cord-306921-3afgpunj	372	5	]	]	-RRB-
cord-306921-3afgpunj	372	6	Pirlindole	Pirlindole	NNP
cord-306921-3afgpunj	372	7	EV	EV	NNP
cord-306921-3afgpunj	372	8	-	-	HYPH
cord-306921-3afgpunj	372	9	D68	D68	NNP
cord-306921-3afgpunj	372	10	and	and	CC
cord-306921-3afgpunj	372	11	CV	CV	NNP
cord-306921-3afgpunj	372	12	-	-	HYPH
cord-306921-3afgpunj	372	13	B3	B3	NNP
cord-306921-3afgpunj	372	14	RNA	RNA	NNP
cord-306921-3afgpunj	372	15	replication	replication	NN
cord-306921-3afgpunj	372	16	stage	stage	NN
cord-306921-3afgpunj	372	17	;	;	:
cord-306921-3afgpunj	372	18	may	may	MD
cord-306921-3afgpunj	372	19	be	be	VB
cord-306921-3afgpunj	372	20	targeting	target	VBG
cord-306921-3afgpunj	372	21	CV	cv	NN
cord-306921-3afgpunj	372	22	-	-	HYPH
cord-306921-3afgpunj	372	23	B3	B3	NNP
cord-306921-3afgpunj	372	24	viral	viral	JJ
cord-306921-3afgpunj	372	25	2C	2c	NN
cord-306921-3afgpunj	372	26	protease	protease	NN
cord-306921-3afgpunj	372	27	Budesonide	Budesonide	NNP
cord-306921-3afgpunj	372	28	RV-14	RV-14	NNP
cord-306921-3afgpunj	372	29	[	[	-LRB-
cord-306921-3afgpunj	372	30	200	200	CD
cord-306921-3afgpunj	372	31	]	]	-RRB-
cord-306921-3afgpunj	372	32	Zuclopenthixol	Zuclopenthixol	NNP
cord-306921-3afgpunj	372	33	EV	EV	NNP
cord-306921-3afgpunj	372	34	-	-	HYPH
cord-306921-3afgpunj	372	35	D68	D68	NNP
cord-306921-3afgpunj	372	36	and	and	CC
cord-306921-3afgpunj	372	37	CV	CV	NNP
cord-306921-3afgpunj	372	38	-	-	HYPH
cord-306921-3afgpunj	372	39	B3	B3	NNP
cord-306921-3afgpunj	372	40	RNA	RNA	NNP
cord-306921-3afgpunj	372	41	replication	replication	NN
cord-306921-3afgpunj	372	42	stage	stage	NN
cord-306921-3afgpunj	372	43	;	;	:
cord-306921-3afgpunj	372	44	may	may	MD
cord-306921-3afgpunj	372	45	be	be	VB
cord-306921-3afgpunj	372	46	targeting	target	VBG
cord-306921-3afgpunj	372	47	CV	cv	NN
cord-306921-3afgpunj	372	48	-	-	HYPH
cord-306921-3afgpunj	372	49	B3	B3	NNP
cord-306921-3afgpunj	372	50	viral	viral	JJ
cord-306921-3afgpunj	372	51	2C	2c	NN
cord-306921-3afgpunj	372	52	protease	protease	NN
cord-306921-3afgpunj	372	53	[	[	-LRB-
cord-306921-3afgpunj	372	54	184	184	CD
cord-306921-3afgpunj	372	55	]	]	-RRB-
cord-306921-3afgpunj	373	1	Apigenin	Apigenin	NNP
cord-306921-3afgpunj	373	2	EV	EV	NNP
cord-306921-3afgpunj	373	3	-	-	HYPH
cord-306921-3afgpunj	373	4	A71	A71	NNP
cord-306921-3afgpunj	374	1	Targeting	target	VBG
cord-306921-3afgpunj	374	2	viral	viral	JJ
cord-306921-3afgpunj	374	3	IRES	IRES	NNP
cord-306921-3afgpunj	374	4	thereby	thereby	RB
cord-306921-3afgpunj	374	5	inhibiting	inhibit	VBG
cord-306921-3afgpunj	374	6	viral	viral	JJ
cord-306921-3afgpunj	374	7	translation	translation	NN
cord-306921-3afgpunj	374	8	process	process	NN
cord-306921-3afgpunj	374	9	[	[	-LRB-
cord-306921-3afgpunj	374	10	191	191	CD
cord-306921-3afgpunj	374	11	]	]	-RRB-
cord-306921-3afgpunj	374	12	[	[	-LRB-
cord-306921-3afgpunj	374	13	192	192	CD
cord-306921-3afgpunj	374	14	]	]	-RRB-
cord-306921-3afgpunj	374	15	[	[	-LRB-
cord-306921-3afgpunj	374	16	193	193	CD
cord-306921-3afgpunj	374	17	]	]	-RRB-
cord-306921-3afgpunj	374	18	 	 	_SP
cord-306921-3afgpunj	374	19	ICTV	ICTV	NNP
cord-306921-3afgpunj	374	20	virus	virus	NN
cord-306921-3afgpunj	374	21	taxonomy	taxonomy	NN
cord-306921-3afgpunj	374	22	profile	profile	NN
cord-306921-3afgpunj	374	23	:	:	:
cord-306921-3afgpunj	374	24	Picornaviridae	Picornaviridae	NNP
cord-306921-3afgpunj	374	25	Enteroviruses	Enteroviruses	NNP
cord-306921-3afgpunj	374	26	as	as	IN
cord-306921-3afgpunj	374	27	agents	agent	NNS
cord-306921-3afgpunj	374	28	of	of	IN
cord-306921-3afgpunj	374	29	emerging	emerge	VBG
cord-306921-3afgpunj	374	30	infectious	infectious	JJ
cord-306921-3afgpunj	374	31	diseases	disease	NNS
cord-306921-3afgpunj	375	1	An	an	DT
cord-306921-3afgpunj	375	2	apparently	apparently	RB
cord-306921-3afgpunj	375	3	new	new	JJ
cord-306921-3afgpunj	375	4	enterovirus	enterovirus	NN
cord-306921-3afgpunj	375	5	isolated	isolate	VBN
cord-306921-3afgpunj	375	6	from	from	IN
cord-306921-3afgpunj	375	7	patients	patient	NNS
cord-306921-3afgpunj	375	8	with	with	IN
cord-306921-3afgpunj	375	9	disease	disease	NN
cord-306921-3afgpunj	375	10	of	of	IN
cord-306921-3afgpunj	375	11	the	the	DT
cord-306921-3afgpunj	375	12	central	central	JJ
cord-306921-3afgpunj	375	13	nervous	nervous	JJ
cord-306921-3afgpunj	375	14	system	system	NN
cord-306921-3afgpunj	375	15	Fatal	fatal	JJ
cord-306921-3afgpunj	375	16	enterovirus	enterovirus	NN
cord-306921-3afgpunj	375	17	71	71	CD
cord-306921-3afgpunj	375	18	encephalomyelitis	encephalomyelitis	NN
cord-306921-3afgpunj	375	19	Bulbar	Bulbar	NNP
cord-306921-3afgpunj	375	20	poliomyelitis	poliomyelitis	NN
cord-306921-3afgpunj	375	21	:	:	:
cord-306921-3afgpunj	376	1	MR	MR	NNP
cord-306921-3afgpunj	376	2	findings	finding	NNS
cord-306921-3afgpunj	376	3	with	with	IN
cord-306921-3afgpunj	376	4	pathologic	pathologic	JJ
cord-306921-3afgpunj	376	5	correlation	correlation	NN
cord-306921-3afgpunj	376	6	Neurologic	neurologic	JJ
cord-306921-3afgpunj	376	7	complications	complication	NNS
cord-306921-3afgpunj	376	8	in	in	IN
cord-306921-3afgpunj	376	9	children	child	NNS
cord-306921-3afgpunj	376	10	with	with	IN
cord-306921-3afgpunj	376	11	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	376	12	71	71	CD
cord-306921-3afgpunj	376	13	infection	infection	NN
cord-306921-3afgpunj	376	14	MR	MR	NNP
cord-306921-3afgpunj	376	15	imaging	image	VBG
cord-306921-3afgpunj	376	16	findings	finding	NNS
cord-306921-3afgpunj	376	17	of	of	IN
cord-306921-3afgpunj	376	18	enteroviral	enteroviral	NNP
cord-306921-3afgpunj	376	19	encephaloymelitis	encephaloymelitis	NNP
cord-306921-3afgpunj	376	20	:	:	:
cord-306921-3afgpunj	376	21	an	an	DT
cord-306921-3afgpunj	376	22	outbreak	outbreak	NN
cord-306921-3afgpunj	376	23	in	in	IN
cord-306921-3afgpunj	376	24	Taiwan	Taiwan	NNP
cord-306921-3afgpunj	376	25	Fatal	fatal	JJ
cord-306921-3afgpunj	376	26	rhabdomyolysis	rhabdomyolysis	NN
cord-306921-3afgpunj	376	27	and	and	CC
cord-306921-3afgpunj	376	28	renal	renal	JJ
cord-306921-3afgpunj	376	29	failure	failure	NN
cord-306921-3afgpunj	376	30	associated	associate	VBN
cord-306921-3afgpunj	376	31	with	with	IN
cord-306921-3afgpunj	376	32	hand	hand	NN
cord-306921-3afgpunj	376	33	,	,	,
cord-306921-3afgpunj	376	34	foot	foot	NN
cord-306921-3afgpunj	376	35	and	and	CC
cord-306921-3afgpunj	376	36	mouth	mouth	NN
cord-306921-3afgpunj	376	37	disease	disease	NN
cord-306921-3afgpunj	376	38	Nephrotic	nephrotic	JJ
cord-306921-3afgpunj	376	39	syndrome	syndrome	NN
cord-306921-3afgpunj	376	40	in	in	IN
cord-306921-3afgpunj	376	41	hand	hand	NN
cord-306921-3afgpunj	376	42	,	,	,
cord-306921-3afgpunj	376	43	foot	foot	NN
cord-306921-3afgpunj	376	44	and	and	CC
cord-306921-3afgpunj	376	45	mouth	mouth	NN
cord-306921-3afgpunj	376	46	disease	disease	NN
cord-306921-3afgpunj	376	47	caused	cause	VBN
cord-306921-3afgpunj	376	48	by	by	IN
cord-306921-3afgpunj	376	49	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	376	50	A16	A16	NNP
cord-306921-3afgpunj	377	1	:	:	:
cord-306921-3afgpunj	377	2	a	a	DT
cord-306921-3afgpunj	377	3	case	case	NN
cord-306921-3afgpunj	377	4	report	report	NN
cord-306921-3afgpunj	377	5	Acute	acute	JJ
cord-306921-3afgpunj	377	6	kidney	kidney	NN
cord-306921-3afgpunj	377	7	injury	injury	NN
cord-306921-3afgpunj	377	8	secondary	secondary	JJ
cord-306921-3afgpunj	377	9	to	to	IN
cord-306921-3afgpunj	377	10	severe	severe	JJ
cord-306921-3afgpunj	377	11	hand	hand	NN
cord-306921-3afgpunj	377	12	,	,	,
cord-306921-3afgpunj	377	13	foot	foot	NN
cord-306921-3afgpunj	377	14	and	and	CC
cord-306921-3afgpunj	377	15	mouth	mouth	NN
cord-306921-3afgpunj	377	16	disease	disease	NN
cord-306921-3afgpunj	377	17	caused	cause	VBN
cord-306921-3afgpunj	377	18	by	by	IN
cord-306921-3afgpunj	377	19	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	377	20	-	-	HYPH
cord-306921-3afgpunj	377	21	A71	A71	NNP
cord-306921-3afgpunj	377	22	:	:	:
cord-306921-3afgpunj	377	23	hypertension	hypertension	NN
cord-306921-3afgpunj	377	24	is	be	VBZ
cord-306921-3afgpunj	377	25	a	a	DT
cord-306921-3afgpunj	377	26	common	common	JJ
cord-306921-3afgpunj	377	27	Seroepidemiology	Seroepidemiology	NNP
cord-306921-3afgpunj	377	28	of	of	IN
cord-306921-3afgpunj	377	29	human	human	JJ
cord-306921-3afgpunj	377	30	enterovirus	enterovirus	NN
cord-306921-3afgpunj	377	31	71	71	CD
cord-306921-3afgpunj	377	32	Hand	Hand	NNP
cord-306921-3afgpunj	377	33	,	,	,
cord-306921-3afgpunj	377	34	foot	foot	NN
cord-306921-3afgpunj	377	35	,	,	,
cord-306921-3afgpunj	377	36	and	and	CC
cord-306921-3afgpunj	377	37	mouth	mouth	NN
cord-306921-3afgpunj	377	38	disease	disease	NN
cord-306921-3afgpunj	377	39	in	in	IN
cord-306921-3afgpunj	377	40	China	China	NNP
cord-306921-3afgpunj	377	41	,	,	,
cord-306921-3afgpunj	377	42	2008	2008	CD
cord-306921-3afgpunj	377	43	-	-	SYM
cord-306921-3afgpunj	377	44	12	12	CD
cord-306921-3afgpunj	377	45	:	:	:
cord-306921-3afgpunj	377	46	an	an	DT
cord-306921-3afgpunj	377	47	epidemiological	epidemiological	JJ
cord-306921-3afgpunj	377	48	study	study	NN
cord-306921-3afgpunj	377	49	Notes	note	NNS
cord-306921-3afgpunj	377	50	from	from	IN
cord-306921-3afgpunj	377	51	the	the	DT
cord-306921-3afgpunj	377	52	Field	field	NN
cord-306921-3afgpunj	377	53	:	:	:
cord-306921-3afgpunj	377	54	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	377	55	A71	A71	NNP
cord-306921-3afgpunj	377	56	neurologic	neurologic	JJ
cord-306921-3afgpunj	377	57	disease	disease	NN
cord-306921-3afgpunj	377	58	in	in	IN
cord-306921-3afgpunj	377	59	children	child	NNS
cord-306921-3afgpunj	378	1	-Colorado	-Colorado	.
cord-306921-3afgpunj	379	1	Cyclical	cyclical	JJ
cord-306921-3afgpunj	379	2	patterns	pattern	NNS
cord-306921-3afgpunj	379	3	of	of	IN
cord-306921-3afgpunj	379	4	hand	hand	NN
cord-306921-3afgpunj	379	5	,	,	,
cord-306921-3afgpunj	379	6	foot	foot	NN
cord-306921-3afgpunj	379	7	and	and	CC
cord-306921-3afgpunj	379	8	mouth	mouth	NN
cord-306921-3afgpunj	379	9	disease	disease	NN
cord-306921-3afgpunj	379	10	caused	cause	VBN
cord-306921-3afgpunj	379	11	by	by	IN
cord-306921-3afgpunj	379	12	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	379	13	A71	A71	NNP
cord-306921-3afgpunj	379	14	in	in	IN
cord-306921-3afgpunj	379	15	Malaysia	Malaysia	NNP
cord-306921-3afgpunj	380	1	The	the	DT
cord-306921-3afgpunj	380	2	seasonality	seasonality	NN
cord-306921-3afgpunj	380	3	of	of	IN
cord-306921-3afgpunj	380	4	nonpolio	nonpolio	NNP
cord-306921-3afgpunj	380	5	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	380	6	in	in	IN
cord-306921-3afgpunj	380	7	the	the	DT
cord-306921-3afgpunj	380	8	United	United	NNP
cord-306921-3afgpunj	380	9	States	States	NNP
cord-306921-3afgpunj	380	10	:	:	:
cord-306921-3afgpunj	380	11	patterns	pattern	NNS
cord-306921-3afgpunj	380	12	and	and	CC
cord-306921-3afgpunj	380	13	drivers	driver	NNS
cord-306921-3afgpunj	380	14	Severity	severity	NN
cord-306921-3afgpunj	380	15	and	and	CC
cord-306921-3afgpunj	380	16	burden	burden	NN
cord-306921-3afgpunj	380	17	of	of	IN
cord-306921-3afgpunj	380	18	hand	hand	NN
cord-306921-3afgpunj	380	19	,	,	,
cord-306921-3afgpunj	380	20	foot	foot	NN
cord-306921-3afgpunj	380	21	and	and	CC
cord-306921-3afgpunj	380	22	mouth	mouth	NN
cord-306921-3afgpunj	380	23	disease	disease	NN
cord-306921-3afgpunj	380	24	in	in	IN
cord-306921-3afgpunj	380	25	Asia	Asia	NNP
cord-306921-3afgpunj	380	26	:	:	:
cord-306921-3afgpunj	380	27	a	a	DT
cord-306921-3afgpunj	380	28	modelling	modelling	NN
cord-306921-3afgpunj	380	29	study	study	NN
cord-306921-3afgpunj	380	30	Identification	identification	NN
cord-306921-3afgpunj	380	31	and	and	CC
cord-306921-3afgpunj	380	32	molecular	molecular	JJ
cord-306921-3afgpunj	380	33	characterization	characterization	NN
cord-306921-3afgpunj	380	34	of	of	IN
cord-306921-3afgpunj	380	35	non	non	JJ
cord-306921-3afgpunj	380	36	-	-	JJ
cord-306921-3afgpunj	380	37	polio	polio	JJ
cord-306921-3afgpunj	380	38	enteroviruses	enterovirus	NNS
cord-306921-3afgpunj	380	39	from	from	IN
cord-306921-3afgpunj	380	40	children	child	NNS
cord-306921-3afgpunj	380	41	with	with	IN
cord-306921-3afgpunj	380	42	acute	acute	JJ
cord-306921-3afgpunj	380	43	flaccid	flaccid	JJ
cord-306921-3afgpunj	380	44	paralysis	paralysis	NN
cord-306921-3afgpunj	380	45	in	in	IN
cord-306921-3afgpunj	380	46	West	West	NNP
cord-306921-3afgpunj	380	47	Africa	Africa	NNP
cord-306921-3afgpunj	381	1	A	a	DT
cord-306921-3afgpunj	381	2	virus	virus	NN
cord-306921-3afgpunj	381	3	recovered	recover	VBN
cord-306921-3afgpunj	381	4	from	from	IN
cord-306921-3afgpunj	381	5	the	the	DT
cord-306921-3afgpunj	381	6	feces	fece	NNS
cord-306921-3afgpunj	381	7	of	of	IN
cord-306921-3afgpunj	381	8	poliomyelitis	poliomyelitis	NN
cord-306921-3afgpunj	381	9	patients	patient	NNS
cord-306921-3afgpunj	381	10	pathogenic	pathogenic	JJ
cord-306921-3afgpunj	381	11	for	for	IN
cord-306921-3afgpunj	381	12	suckling	suckle	VBG
cord-306921-3afgpunj	381	13	mice	mouse	NNS
cord-306921-3afgpunj	381	14	Characterization	characterization	NN
cord-306921-3afgpunj	381	15	of	of	IN
cord-306921-3afgpunj	381	16	genome	genome	NN
cord-306921-3afgpunj	381	17	sequences	sequence	NNS
cord-306921-3afgpunj	381	18	and	and	CC
cord-306921-3afgpunj	381	19	clinical	clinical	JJ
cord-306921-3afgpunj	381	20	features	feature	NNS
cord-306921-3afgpunj	381	21	of	of	IN
cord-306921-3afgpunj	381	22	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	381	23	A6	A6	NNP
cord-306921-3afgpunj	381	24	strains	strain	NNS
cord-306921-3afgpunj	381	25	collected	collect	VBN
cord-306921-3afgpunj	381	26	in	in	IN
cord-306921-3afgpunj	381	27	Hyogo	Hyogo	NNP
cord-306921-3afgpunj	381	28	,	,	,
cord-306921-3afgpunj	381	29	Japan	Japan	NNP
cord-306921-3afgpunj	381	30	in	in	IN
cord-306921-3afgpunj	381	31	1999	1999	CD
cord-306921-3afgpunj	381	32	-	-	SYM
cord-306921-3afgpunj	381	33	2013	2013	CD
cord-306921-3afgpunj	381	34	Emerging	Emerging	NNP
cord-306921-3afgpunj	381	35	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	381	36	A6	A6	NNP
cord-306921-3afgpunj	381	37	causing	cause	VBG
cord-306921-3afgpunj	381	38	hand	hand	NN
cord-306921-3afgpunj	381	39	,	,	,
cord-306921-3afgpunj	381	40	foot	foot	NN
cord-306921-3afgpunj	381	41	and	and	CC
cord-306921-3afgpunj	381	42	mouth	mouth	NN
cord-306921-3afgpunj	381	43	disease	disease	NN
cord-306921-3afgpunj	381	44	Hand	Hand	NNP
cord-306921-3afgpunj	381	45	,	,	,
cord-306921-3afgpunj	381	46	foot	foot	NN
cord-306921-3afgpunj	381	47	,	,	,
cord-306921-3afgpunj	381	48	and	and	CC
cord-306921-3afgpunj	381	49	mouth	mouth	NN
cord-306921-3afgpunj	381	50	disease	disease	NN
cord-306921-3afgpunj	381	51	outbreak	outbreak	NN
cord-306921-3afgpunj	381	52	and	and	CC
cord-306921-3afgpunj	381	53	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	381	54	A6	A6	NNP
cord-306921-3afgpunj	381	55	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	381	56	A6	A6	NNP
cord-306921-3afgpunj	381	57	and	and	CC
cord-306921-3afgpunj	381	58	hand	hand	NN
cord-306921-3afgpunj	381	59	,	,	,
cord-306921-3afgpunj	381	60	foot	foot	NN
cord-306921-3afgpunj	381	61	,	,	,
cord-306921-3afgpunj	381	62	and	and	CC
cord-306921-3afgpunj	381	63	mouth	mouth	NN
cord-306921-3afgpunj	381	64	disease	disease	NN
cord-306921-3afgpunj	382	1	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	382	2	A6	A6	NNP
cord-306921-3afgpunj	382	3	:	:	:
cord-306921-3afgpunj	382	4	a	a	DT
cord-306921-3afgpunj	382	5	new	new	JJ
cord-306921-3afgpunj	382	6	emerging	emerge	VBG
cord-306921-3afgpunj	382	7	pathogen	pathogen	NN
cord-306921-3afgpunj	382	8	causing	cause	VBG
cord-306921-3afgpunj	382	9	hand	hand	NN
cord-306921-3afgpunj	382	10	,	,	,
cord-306921-3afgpunj	382	11	foot	foot	NN
cord-306921-3afgpunj	382	12	and	and	CC
cord-306921-3afgpunj	382	13	mouth	mouth	NN
cord-306921-3afgpunj	382	14	disease	disease	NN
cord-306921-3afgpunj	382	15	outbreaks	outbreak	NNS
cord-306921-3afgpunj	382	16	worldwide	worldwide	RB
cord-306921-3afgpunj	382	17	Epidemics	epidemic	NNS
cord-306921-3afgpunj	382	18	and	and	CC
cord-306921-3afgpunj	382	19	aetiology	aetiology	NN
cord-306921-3afgpunj	382	20	of	of	IN
cord-306921-3afgpunj	382	21	hand	hand	NN
cord-306921-3afgpunj	382	22	Outbreak	outbreak	NN
cord-306921-3afgpunj	382	23	of	of	IN
cord-306921-3afgpunj	382	24	hand	hand	NN
cord-306921-3afgpunj	382	25	,	,	,
cord-306921-3afgpunj	382	26	foot	foot	NN
cord-306921-3afgpunj	382	27	and	and	CC
cord-306921-3afgpunj	382	28	mouth	mouth	NN
cord-306921-3afgpunj	382	29	disease	disease	NNP
cord-306921-3afgpunj	382	30	/	/	SYM
cord-306921-3afgpunj	382	31	herpangina	herpangina	NNP
cord-306921-3afgpunj	382	32	associated	associate	VBN
cord-306921-3afgpunj	382	33	with	with	IN
cord-306921-3afgpunj	382	34	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	382	35	A6	A6	NNP
cord-306921-3afgpunj	382	36	and	and	CC
cord-306921-3afgpunj	382	37	A10	A10	NNP
cord-306921-3afgpunj	382	38	infections	infection	NNS
cord-306921-3afgpunj	382	39	in	in	IN
cord-306921-3afgpunj	382	40	2010	2010	CD
cord-306921-3afgpunj	382	41	,	,	,
cord-306921-3afgpunj	382	42	France	France	NNP
cord-306921-3afgpunj	382	43	:	:	:
cord-306921-3afgpunj	382	44	a	a	DT
cord-306921-3afgpunj	382	45	large	large	JJ
cord-306921-3afgpunj	382	46	citywide	citywide	JJ
cord-306921-3afgpunj	382	47	,	,	,
cord-306921-3afgpunj	382	48	prospective	prospective	JJ
cord-306921-3afgpunj	382	49	observational	observational	JJ
cord-306921-3afgpunj	382	50	study	study	NN
cord-306921-3afgpunj	382	51	Characterization	characterization	NN
cord-306921-3afgpunj	382	52	of	of	IN
cord-306921-3afgpunj	382	53	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	382	54	A6-and	A6-and	NNP
cord-306921-3afgpunj	382	55	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	382	56	71-Associated	71-Associated	NNP
cord-306921-3afgpunj	382	57	Hand	Hand	NNP
cord-306921-3afgpunj	382	58	Foot	Foot	NNP
cord-306921-3afgpunj	382	59	and	and	CC
cord-306921-3afgpunj	382	60	Mouth	Mouth	NNP
cord-306921-3afgpunj	382	61	Disease	Disease	NNP
cord-306921-3afgpunj	382	62	in	in	IN
cord-306921-3afgpunj	382	63	Beijing	Beijing	NNP
cord-306921-3afgpunj	382	64	,	,	,
cord-306921-3afgpunj	382	65	China	China	NNP
cord-306921-3afgpunj	382	66	Recombinant	Recombinant	NNP
cord-306921-3afgpunj	382	67	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	382	68	A2	A2	NNP
cord-306921-3afgpunj	382	69	and	and	CC
cord-306921-3afgpunj	382	70	deaths	death	NNS
cord-306921-3afgpunj	382	71	of	of	IN
cord-306921-3afgpunj	382	72	children	child	NNS
cord-306921-3afgpunj	382	73	Emergence	Emergence	NNP
cord-306921-3afgpunj	382	74	,	,	,
cord-306921-3afgpunj	382	75	circulation	circulation	NN
cord-306921-3afgpunj	382	76	,	,	,
cord-306921-3afgpunj	382	77	and	and	CC
cord-306921-3afgpunj	382	78	spatiotemporal	spatiotemporal	JJ
cord-306921-3afgpunj	382	79	phylogenetic	phylogenetic	JJ
cord-306921-3afgpunj	382	80	analysis	analysis	NN
cord-306921-3afgpunj	382	81	of	of	IN
cord-306921-3afgpunj	382	82	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	382	83	a6-and	a6-and	NNP
cord-306921-3afgpunj	382	84	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	382	85	a10-associated	a10-associate	VBD
cord-306921-3afgpunj	382	86	hand	hand	NN
cord-306921-3afgpunj	382	87	,	,	,
cord-306921-3afgpunj	382	88	foot	foot	NN
cord-306921-3afgpunj	382	89	,	,	,
cord-306921-3afgpunj	382	90	and	and	CC
cord-306921-3afgpunj	382	91	mouth	mouth	NN
cord-306921-3afgpunj	382	92	disease	disease	NN
cord-306921-3afgpunj	382	93	infections	infection	NNS
cord-306921-3afgpunj	382	94	from	from	IN
cord-306921-3afgpunj	382	95	Circulation	Circulation	NNP
cord-306921-3afgpunj	382	96	of	of	IN
cord-306921-3afgpunj	382	97	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	382	98	A10	A10	NNP
cord-306921-3afgpunj	382	99	and	and	CC
cord-306921-3afgpunj	382	100	A6	A6	NNP
cord-306921-3afgpunj	382	101	in	in	IN
cord-306921-3afgpunj	382	102	hand	hand	NN
cord-306921-3afgpunj	382	103	-	-	HYPH
cord-306921-3afgpunj	382	104	foot	foot	NN
cord-306921-3afgpunj	382	105	-	-	HYPH
cord-306921-3afgpunj	382	106	mouth	mouth	NN
cord-306921-3afgpunj	382	107	disease	disease	NN
cord-306921-3afgpunj	382	108	in	in	IN
cord-306921-3afgpunj	382	109	China	China	NNP
cord-306921-3afgpunj	382	110	Emerging	Emerging	NNP
cord-306921-3afgpunj	382	111	enteroviruses	enteroviruses	XX
cord-306921-3afgpunj	382	112	causing	cause	VBG
cord-306921-3afgpunj	383	1	hand	hand	NN
cord-306921-3afgpunj	383	2	,	,	,
cord-306921-3afgpunj	383	3	foot	foot	NN
cord-306921-3afgpunj	383	4	and	and	CC
cord-306921-3afgpunj	383	5	mouth	mouth	NN
cord-306921-3afgpunj	383	6	disease	disease	NN
cord-306921-3afgpunj	383	7	Complete	Complete	NNP
cord-306921-3afgpunj	383	8	genome	genome	NN
cord-306921-3afgpunj	383	9	analysis	analysis	NN
cord-306921-3afgpunj	383	10	of	of	IN
cord-306921-3afgpunj	383	11	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	383	12	A2	A2	NNP
cord-306921-3afgpunj	383	13	,	,	,
cord-306921-3afgpunj	384	1	A4	A4	NNP
cord-306921-3afgpunj	384	2	,	,	,
cord-306921-3afgpunj	384	3	A5	A5	NNP
cord-306921-3afgpunj	384	4	,	,	,
cord-306921-3afgpunj	384	5	and	and	CC
cord-306921-3afgpunj	384	6	A10	A10	NNP
cord-306921-3afgpunj	384	7	strains	strain	NNS
cord-306921-3afgpunj	384	8	isolated	isolate	VBN
cord-306921-3afgpunj	384	9	from	from	IN
cord-306921-3afgpunj	384	10	hand	hand	NN
cord-306921-3afgpunj	384	11	,	,	,
cord-306921-3afgpunj	384	12	foot	foot	NN
cord-306921-3afgpunj	384	13	,	,	,
cord-306921-3afgpunj	384	14	and	and	CC
cord-306921-3afgpunj	384	15	mouth	mouth	NN
cord-306921-3afgpunj	384	16	disease	disease	NN
cord-306921-3afgpunj	384	17	patients	patient	NNS
cord-306921-3afgpunj	384	18	in	in	IN
cord-306921-3afgpunj	384	19	China	China	NNP
cord-306921-3afgpunj	384	20	revealing	reveal	VBG
cord-306921-3afgpunj	384	21	frequent	frequent	JJ
cord-306921-3afgpunj	384	22	recombination	recombination	NN
cord-306921-3afgpunj	384	23	of	of	IN
cord-306921-3afgpunj	384	24	human	human	JJ
cord-306921-3afgpunj	384	25	enterovirus	enterovirus	NN
cord-306921-3afgpunj	384	26	A	a	DT
cord-306921-3afgpunj	384	27	A	a	DT
cord-306921-3afgpunj	384	28	probable	probable	JJ
cord-306921-3afgpunj	384	29	new	new	JJ
cord-306921-3afgpunj	384	30	human	human	JJ
cord-306921-3afgpunj	384	31	picornavirus	picornavirus	NN
cord-306921-3afgpunj	384	32	associated	associate	VBN
cord-306921-3afgpunj	384	33	with	with	IN
cord-306921-3afgpunj	384	34	respiratory	respiratory	JJ
cord-306921-3afgpunj	384	35	disease1	disease1	NN
cord-306921-3afgpunj	384	36	Acute	acute	JJ
cord-306921-3afgpunj	384	37	flaccid	flaccid	JJ
cord-306921-3afgpunj	384	38	myelitis	myelitis	NN
cord-306921-3afgpunj	384	39	associated	associate	VBN
cord-306921-3afgpunj	384	40	with	with	IN
cord-306921-3afgpunj	384	41	enterovirus	enterovirus	NN
cord-306921-3afgpunj	384	42	D68	D68	NNP
cord-306921-3afgpunj	384	43	infection	infection	NN
cord-306921-3afgpunj	384	44	Severe	severe	JJ
cord-306921-3afgpunj	384	45	respiratory	respiratory	JJ
cord-306921-3afgpunj	384	46	illness	illness	NN
cord-306921-3afgpunj	384	47	associated	associate	VBN
cord-306921-3afgpunj	384	48	with	with	IN
cord-306921-3afgpunj	384	49	a	a	DT
cord-306921-3afgpunj	384	50	nationwide	nationwide	JJ
cord-306921-3afgpunj	384	51	outbreak	outbreak	NN
cord-306921-3afgpunj	384	52	of	of	IN
cord-306921-3afgpunj	384	53	enterovirus	enterovirus	NN
cord-306921-3afgpunj	384	54	D68	D68	NNP
cord-306921-3afgpunj	384	55	in	in	IN
cord-306921-3afgpunj	384	56	the	the	DT
cord-306921-3afgpunj	384	57	USA	USA	NNP
cord-306921-3afgpunj	384	58	(	(	-LRB-
cord-306921-3afgpunj	384	59	2014	2014	CD
cord-306921-3afgpunj	384	60	)	)	-RRB-
cord-306921-3afgpunj	385	1	:	:	:
cord-306921-3afgpunj	385	2	a	a	DT
cord-306921-3afgpunj	385	3	descriptive	descriptive	JJ
cord-306921-3afgpunj	385	4	epidemiological	epidemiological	JJ
cord-306921-3afgpunj	385	5	investigation	investigation	NN
cord-306921-3afgpunj	385	6	Pediatric	pediatric	JJ
cord-306921-3afgpunj	385	7	acute	acute	JJ
cord-306921-3afgpunj	385	8	flaccid	flaccid	JJ
cord-306921-3afgpunj	385	9	paralysis	paralysis	NN
cord-306921-3afgpunj	385	10	:	:	:
cord-306921-3afgpunj	386	1	Enterovirus	enterovirus	NN
cord-306921-3afgpunj	386	2	D68-associated	D68-associated	NNP
cord-306921-3afgpunj	386	3	anterior	anterior	NNP
cord-306921-3afgpunj	386	4	myelitis	myelitis	NNP
cord-306921-3afgpunj	387	1	The	the	DT
cord-306921-3afgpunj	387	2	association	association	NN
cord-306921-3afgpunj	387	3	between	between	IN
cord-306921-3afgpunj	387	4	acute	acute	JJ
cord-306921-3afgpunj	387	5	flaccid	flaccid	JJ
cord-306921-3afgpunj	387	6	myelitis	myelitis	NN
cord-306921-3afgpunj	387	7	(	(	-LRB-
cord-306921-3afgpunj	387	8	AFM	AFM	NNP
cord-306921-3afgpunj	387	9	)	)	-RRB-
cord-306921-3afgpunj	387	10	and	and	CC
cord-306921-3afgpunj	387	11	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	387	12	D68	D68	NNP
cord-306921-3afgpunj	387	13	(	(	-LRB-
cord-306921-3afgpunj	387	14	EV	EV	NNP
cord-306921-3afgpunj	387	15	-	-	HYPH
cord-306921-3afgpunj	387	16	D68	D68	NNP
cord-306921-3afgpunj	387	17	)	)	-RRB-
cord-306921-3afgpunj	388	1	-what	-what	WP
cord-306921-3afgpunj	388	2	is	be	VBZ
cord-306921-3afgpunj	388	3	the	the	DT
cord-306921-3afgpunj	388	4	evidence	evidence	NN
cord-306921-3afgpunj	388	5	for	for	IN
cord-306921-3afgpunj	388	6	causation	causation	NN
cord-306921-3afgpunj	388	7	?	?	.
cord-306921-3afgpunj	389	1	Eurosurveillance	Eurosurveillance	NNP
cord-306921-3afgpunj	389	2	Contemporary	contemporary	JJ
cord-306921-3afgpunj	389	3	circulating	circulate	VBG
cord-306921-3afgpunj	389	4	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	389	5	D68	D68	NNP
cord-306921-3afgpunj	389	6	strains	strain	NNS
cord-306921-3afgpunj	389	7	have	have	VBP
cord-306921-3afgpunj	389	8	acquired	acquire	VBN
cord-306921-3afgpunj	389	9	the	the	DT
cord-306921-3afgpunj	389	10	capacity	capacity	NN
cord-306921-3afgpunj	389	11	for	for	IN
cord-306921-3afgpunj	389	12	viral	viral	JJ
cord-306921-3afgpunj	389	13	entry	entry	NN
cord-306921-3afgpunj	389	14	and	and	CC
cord-306921-3afgpunj	389	15	replication	replication	NN
cord-306921-3afgpunj	389	16	in	in	IN
cord-306921-3afgpunj	389	17	human	human	JJ
cord-306921-3afgpunj	389	18	neuronal	neuronal	JJ
cord-306921-3afgpunj	389	19	cells	cell	NNS
cord-306921-3afgpunj	389	20	Molecular	molecular	JJ
cord-306921-3afgpunj	389	21	diversity	diversity	NN
cord-306921-3afgpunj	389	22	and	and	CC
cord-306921-3afgpunj	389	23	biennial	biennial	JJ
cord-306921-3afgpunj	389	24	circulation	circulation	NN
cord-306921-3afgpunj	389	25	of	of	IN
cord-306921-3afgpunj	389	26	enterovirus	enterovirus	NN
cord-306921-3afgpunj	389	27	D68	D68	NNP
cord-306921-3afgpunj	389	28	:	:	:
cord-306921-3afgpunj	389	29	a	a	DT
cord-306921-3afgpunj	389	30	systematic	systematic	JJ
cord-306921-3afgpunj	389	31	screening	screening	NN
cord-306921-3afgpunj	389	32	study	study	NN
cord-306921-3afgpunj	389	33	in	in	IN
cord-306921-3afgpunj	389	34	Lyon	Lyon	NNP
cord-306921-3afgpunj	389	35	A	a	DT
cord-306921-3afgpunj	389	36	mouse	mouse	NN
cord-306921-3afgpunj	389	37	model	model	NN
cord-306921-3afgpunj	389	38	of	of	IN
cord-306921-3afgpunj	389	39	paralytic	paralytic	JJ
cord-306921-3afgpunj	389	40	myelitis	myelitis	NN
cord-306921-3afgpunj	389	41	caused	cause	VBN
cord-306921-3afgpunj	389	42	by	by	IN
cord-306921-3afgpunj	389	43	enterovirus	enterovirus	NN
cord-306921-3afgpunj	389	44	D68	D68	NNP
cord-306921-3afgpunj	390	1	The	the	DT
cord-306921-3afgpunj	390	2	essential	essential	JJ
cord-306921-3afgpunj	390	3	role	role	NN
cord-306921-3afgpunj	390	4	of	of	IN
cord-306921-3afgpunj	390	5	Clathrinmediated	clathrinmediate	VBN
cord-306921-3afgpunj	390	6	endocytosis	endocytosis	NN
cord-306921-3afgpunj	390	7	in	in	IN
cord-306921-3afgpunj	390	8	the	the	DT
cord-306921-3afgpunj	390	9	infectious	infectious	JJ
cord-306921-3afgpunj	390	10	entry	entry	NN
cord-306921-3afgpunj	390	11	of	of	IN
cord-306921-3afgpunj	390	12	human	human	JJ
cord-306921-3afgpunj	390	13	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	390	14	71	71	CD
cord-306921-3afgpunj	390	15	Human	Human	NNP
cord-306921-3afgpunj	390	16	SCARB2-mediated	SCARB2-mediated	NNP
cord-306921-3afgpunj	390	17	entry	entry	NN
cord-306921-3afgpunj	390	18	and	and	CC
cord-306921-3afgpunj	390	19	endocytosis	endocytosis	NN
cord-306921-3afgpunj	390	20	of	of	IN
cord-306921-3afgpunj	390	21	EV71	EV71	NNP
cord-306921-3afgpunj	390	22	Enhanced	Enhanced	NNP
cord-306921-3afgpunj	390	23	human	human	JJ
cord-306921-3afgpunj	390	24	enterovirus	enterovirus	NN
cord-306921-3afgpunj	390	25	71	71	CD
cord-306921-3afgpunj	390	26	infection	infection	NN
cord-306921-3afgpunj	390	27	by	by	IN
cord-306921-3afgpunj	390	28	endocytosis	endocytosis	NN
cord-306921-3afgpunj	390	29	inhibitors	inhibitor	NNS
cord-306921-3afgpunj	390	30	reveals	reveal	VBZ
cord-306921-3afgpunj	390	31	multiple	multiple	JJ
cord-306921-3afgpunj	390	32	entry	entry	NN
cord-306921-3afgpunj	390	33	pathways	pathway	NNS
cord-306921-3afgpunj	390	34	by	by	IN
cord-306921-3afgpunj	390	35	enterovirus	enterovirus	NN
cord-306921-3afgpunj	390	36	causing	cause	VBG
cord-306921-3afgpunj	390	37	hand	hand	NN
cord-306921-3afgpunj	390	38	-	-	HYPH
cord-306921-3afgpunj	390	39	foot	foot	NN
cord-306921-3afgpunj	390	40	-	-	HYPH
cord-306921-3afgpunj	390	41	and	and	CC
cord-306921-3afgpunj	390	42	-	-	HYPH
cord-306921-3afgpunj	390	43	mouth	mouth	NN
cord-306921-3afgpunj	390	44	diseases	disease	NNS
cord-306921-3afgpunj	391	1	The	the	DT
cord-306921-3afgpunj	391	2	major	major	JJ
cord-306921-3afgpunj	391	3	human	human	JJ
cord-306921-3afgpunj	391	4	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	391	5	receptor	receptor	NN
cord-306921-3afgpunj	391	6	is	be	VBZ
cord-306921-3afgpunj	391	7	ICAM-1	ICAM-1	NNP
cord-306921-3afgpunj	391	8	Cellular	cellular	JJ
cord-306921-3afgpunj	391	9	receptor	receptor	NN
cord-306921-3afgpunj	391	10	for	for	IN
cord-306921-3afgpunj	391	11	poliovirus	poliovirus	NN
cord-306921-3afgpunj	391	12	:	:	:
cord-306921-3afgpunj	392	1	molecular	molecular	JJ
cord-306921-3afgpunj	392	2	cloning	cloning	NN
cord-306921-3afgpunj	392	3	,	,	,
cord-306921-3afgpunj	392	4	nucleotide	nucleotide	JJ
cord-306921-3afgpunj	392	5	sequence	sequence	NN
cord-306921-3afgpunj	392	6	,	,	,
cord-306921-3afgpunj	392	7	and	and	CC
cord-306921-3afgpunj	392	8	expression	expression	NN
cord-306921-3afgpunj	392	9	of	of	IN
cord-306921-3afgpunj	392	10	a	a	DT
cord-306921-3afgpunj	392	11	new	new	JJ
cord-306921-3afgpunj	392	12	member	member	NN
cord-306921-3afgpunj	392	13	of	of	IN
cord-306921-3afgpunj	392	14	the	the	DT
cord-306921-3afgpunj	392	15	immunoglobulin	immunoglobulin	NN
cord-306921-3afgpunj	392	16	superfamily	superfamily	NN
cord-306921-3afgpunj	392	17	Scavenger	Scavenger	NNP
cord-306921-3afgpunj	392	18	receptor	receptor	NN
cord-306921-3afgpunj	392	19	B2	b2	NN
cord-306921-3afgpunj	392	20	is	be	VBZ
cord-306921-3afgpunj	392	21	a	a	DT
cord-306921-3afgpunj	392	22	cellular	cellular	JJ
cord-306921-3afgpunj	392	23	receptor	receptor	NN
cord-306921-3afgpunj	392	24	for	for	IN
cord-306921-3afgpunj	392	25	enterovirus	enterovirus	NN
cord-306921-3afgpunj	392	26	71	71	CD
cord-306921-3afgpunj	392	27	LIMP-2	LIMP-2	NNP
cord-306921-3afgpunj	392	28	is	be	VBZ
cord-306921-3afgpunj	392	29	a	a	DT
cord-306921-3afgpunj	392	30	receptor	receptor	NN
cord-306921-3afgpunj	392	31	for	for	IN
cord-306921-3afgpunj	392	32	lysosomal	lysosomal	JJ
cord-306921-3afgpunj	392	33	Mannose-6-phosphate	mannose-6-phosphate	NN
cord-306921-3afgpunj	392	34	-	-	HYPH
cord-306921-3afgpunj	392	35	independent	independent	JJ
cord-306921-3afgpunj	392	36	targeting	targeting	NN
cord-306921-3afgpunj	392	37	of	of	IN
cord-306921-3afgpunj	392	38	β	β	NNP
cord-306921-3afgpunj	392	39	-	-	HYPH
cord-306921-3afgpunj	392	40	Glucocerebrosidase	Glucocerebrosidase	NNP
cord-306921-3afgpunj	392	41	Cellular	Cellular	NNP
cord-306921-3afgpunj	392	42	receptors	receptor	NNS
cord-306921-3afgpunj	392	43	for	for	IN
cord-306921-3afgpunj	392	44	human	human	JJ
cord-306921-3afgpunj	392	45	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	392	46	species	specie	NNS
cord-306921-3afgpunj	392	47	a	a	DT
cord-306921-3afgpunj	392	48	Molecular	Molecular	NNP
cord-306921-3afgpunj	392	49	mechanism	mechanism	NN
cord-306921-3afgpunj	392	50	of	of	IN
cord-306921-3afgpunj	392	51	SCARB2-mediated	SCARB2-mediated	NNP
cord-306921-3afgpunj	392	52	attachment	attachment	NN
cord-306921-3afgpunj	392	53	and	and	CC
cord-306921-3afgpunj	392	54	uncoating	uncoating	NN
cord-306921-3afgpunj	392	55	of	of	IN
cord-306921-3afgpunj	392	56	EV71	EV71	NNP
cord-306921-3afgpunj	392	57	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	392	58	71	71	CD
cord-306921-3afgpunj	392	59	binding	binding	NN
cord-306921-3afgpunj	392	60	to	to	IN
cord-306921-3afgpunj	392	61	PSGL-1	PSGL-1	NNP
cord-306921-3afgpunj	392	62	on	on	IN
cord-306921-3afgpunj	392	63	leukocytes	leukocyte	NNS
cord-306921-3afgpunj	392	64	:	:	:
cord-306921-3afgpunj	392	65	VP1	vp1	NN
cord-306921-3afgpunj	392	66	-	-	HYPH
cord-306921-3afgpunj	392	67	145	145	CD
cord-306921-3afgpunj	392	68	acts	act	NNS
cord-306921-3afgpunj	392	69	as	as	IN
cord-306921-3afgpunj	392	70	a	a	DT
cord-306921-3afgpunj	392	71	molecular	molecular	JJ
cord-306921-3afgpunj	392	72	switch	switch	NN
cord-306921-3afgpunj	392	73	to	to	TO
cord-306921-3afgpunj	392	74	control	control	VB
cord-306921-3afgpunj	392	75	receptor	receptor	NN
cord-306921-3afgpunj	392	76	interaction	interaction	NN
cord-306921-3afgpunj	393	1	Human	Human	NNP
cord-306921-3afgpunj	393	2	P	P	NNP
cord-306921-3afgpunj	393	3	-	-	HYPH
cord-306921-3afgpunj	393	4	selectin	selectin	NNP
cord-306921-3afgpunj	393	5	glycoprotein	glycoprotein	NN
cord-306921-3afgpunj	393	6	ligand-1	ligand-1	NNP
cord-306921-3afgpunj	393	7	is	be	VBZ
cord-306921-3afgpunj	393	8	a	a	DT
cord-306921-3afgpunj	393	9	functional	functional	JJ
cord-306921-3afgpunj	393	10	receptor	receptor	NN
cord-306921-3afgpunj	393	11	for	for	IN
cord-306921-3afgpunj	393	12	enterovirus	enterovirus	NN
cord-306921-3afgpunj	393	13	71	71	CD
cord-306921-3afgpunj	393	14	Selectins	Selectins	NNPS
cord-306921-3afgpunj	393	15	in	in	IN
cord-306921-3afgpunj	393	16	T	t	NN
cord-306921-3afgpunj	393	17	-	-	HYPH
cord-306921-3afgpunj	393	18	cell	cell	NN
cord-306921-3afgpunj	393	19	recruitment	recruitment	NN
cord-306921-3afgpunj	393	20	to	to	IN
cord-306921-3afgpunj	393	21	non	non	JJ
cord-306921-3afgpunj	393	22	-	-	JJ
cord-306921-3afgpunj	393	23	lymphoid	lymphoid	JJ
cord-306921-3afgpunj	393	24	tissues	tissue	NNS
cord-306921-3afgpunj	393	25	and	and	CC
cord-306921-3afgpunj	393	26	sites	site	NNS
cord-306921-3afgpunj	393	27	of	of	IN
cord-306921-3afgpunj	393	28	inflammation	inflammation	NN
cord-306921-3afgpunj	393	29	Functional	functional	JJ
cord-306921-3afgpunj	393	30	comparison	comparison	NN
cord-306921-3afgpunj	393	31	of	of	IN
cord-306921-3afgpunj	393	32	SCARB2	SCARB2	NNS
cord-306921-3afgpunj	393	33	and	and	CC
cord-306921-3afgpunj	393	34	PSGL1	PSGL1	NNP
cord-306921-3afgpunj	393	35	as	as	IN
cord-306921-3afgpunj	393	36	receptors	receptor	NNS
cord-306921-3afgpunj	393	37	for	for	IN
cord-306921-3afgpunj	393	38	enterovirus	enterovirus	NN
cord-306921-3afgpunj	393	39	71	71	CD
cord-306921-3afgpunj	393	40	Sialylated	Sialylated	NNP
cord-306921-3afgpunj	393	41	glycans	glycan	NNS
cord-306921-3afgpunj	393	42	as	as	IN
cord-306921-3afgpunj	393	43	receptor	receptor	NN
cord-306921-3afgpunj	393	44	and	and	CC
cord-306921-3afgpunj	393	45	inhibitor	inhibitor	NN
cord-306921-3afgpunj	393	46	of	of	IN
cord-306921-3afgpunj	393	47	enterovirus	enterovirus	NN
cord-306921-3afgpunj	393	48	71	71	CD
cord-306921-3afgpunj	393	49	infection	infection	NN
cord-306921-3afgpunj	393	50	to	to	IN
cord-306921-3afgpunj	393	51	DLD-1	dld-1	JJ
cord-306921-3afgpunj	393	52	intestinal	intestinal	JJ
cord-306921-3afgpunj	393	53	cells	cell	NNS
cord-306921-3afgpunj	393	54	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	393	55	71	71	CD
cord-306921-3afgpunj	393	56	uses	use	VBZ
cord-306921-3afgpunj	393	57	cell	cell	NN
cord-306921-3afgpunj	393	58	surface	surface	NN
cord-306921-3afgpunj	393	59	heparan	heparan	NN
cord-306921-3afgpunj	393	60	sulfate	sulfate	NN
cord-306921-3afgpunj	393	61	glycosaminoglycan	glycosaminoglycan	NN
cord-306921-3afgpunj	393	62	as	as	IN
cord-306921-3afgpunj	393	63	an	an	DT
cord-306921-3afgpunj	393	64	attachment	attachment	NN
cord-306921-3afgpunj	393	65	receptor	receptor	NN
cord-306921-3afgpunj	393	66	A	a	DT
cord-306921-3afgpunj	393	67	VP1	vp1	NN
cord-306921-3afgpunj	393	68	mutation	mutation	NN
cord-306921-3afgpunj	393	69	acquired	acquire	VBN
cord-306921-3afgpunj	393	70	during	during	IN
cord-306921-3afgpunj	393	71	an	an	DT
cord-306921-3afgpunj	393	72	enterovirus	enterovirus	NN
cord-306921-3afgpunj	393	73	71	71	CD
cord-306921-3afgpunj	393	74	disseminated	disseminate	VBN
cord-306921-3afgpunj	393	75	infection	infection	NN
cord-306921-3afgpunj	393	76	confers	confer	VBZ
cord-306921-3afgpunj	393	77	heparan	heparan	NN
cord-306921-3afgpunj	393	78	sulfate	sulfate	NN
cord-306921-3afgpunj	393	79	binding	bind	VBG
cord-306921-3afgpunj	393	80	ability	ability	NN
cord-306921-3afgpunj	393	81	and	and	CC
cord-306921-3afgpunj	393	82	modulates	modulate	VBZ
cord-306921-3afgpunj	394	1	ex	ex	FW
cord-306921-3afgpunj	394	2	vivo	vivo	NN
cord-306921-3afgpunj	394	3	tropism	tropism	NN
cord-306921-3afgpunj	394	4	Annexin	Annexin	NNP
cord-306921-3afgpunj	394	5	II	II	NNP
cord-306921-3afgpunj	394	6	binds	bind	VBZ
cord-306921-3afgpunj	394	7	to	to	IN
cord-306921-3afgpunj	394	8	capsid	capsid	NN
cord-306921-3afgpunj	394	9	protein	protein	NN
cord-306921-3afgpunj	394	10	VP1	vp1	NN
cord-306921-3afgpunj	394	11	of	of	IN
cord-306921-3afgpunj	394	12	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	394	13	71	71	CD
cord-306921-3afgpunj	394	14	and	and	CC
cord-306921-3afgpunj	394	15	enhances	enhance	VBZ
cord-306921-3afgpunj	394	16	viral	viral	JJ
cord-306921-3afgpunj	394	17	infectivity	infectivity	NN
cord-306921-3afgpunj	394	18	Cell	cell	NN
cord-306921-3afgpunj	394	19	surface	surface	NN
cord-306921-3afgpunj	394	20	vimentin	vimentin	NN
cord-306921-3afgpunj	394	21	is	be	VBZ
cord-306921-3afgpunj	394	22	an	an	DT
cord-306921-3afgpunj	394	23	attachment	attachment	NN
cord-306921-3afgpunj	394	24	receptor	receptor	NN
cord-306921-3afgpunj	394	25	for	for	IN
cord-306921-3afgpunj	394	26	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	394	27	71	71	CD
cord-306921-3afgpunj	394	28	Cell	Cell	NNP
cord-306921-3afgpunj	394	29	surface	surface	NN
cord-306921-3afgpunj	394	30	nucleolin	nucleolin	NN
cord-306921-3afgpunj	394	31	facilitates	facilitate	VBZ
cord-306921-3afgpunj	394	32	enterovirus	enterovirus	NN
cord-306921-3afgpunj	394	33	71	71	CD
cord-306921-3afgpunj	394	34	binding	binding	NN
cord-306921-3afgpunj	394	35	and	and	CC
cord-306921-3afgpunj	394	36	infection	infection	NN
cord-306921-3afgpunj	395	1	Prohibitin	Prohibitin	NNP
cord-306921-3afgpunj	395	2	plays	play	VBZ
cord-306921-3afgpunj	395	3	a	a	DT
cord-306921-3afgpunj	395	4	critical	critical	JJ
cord-306921-3afgpunj	395	5	role	role	NN
cord-306921-3afgpunj	395	6	in	in	IN
cord-306921-3afgpunj	395	7	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	395	8	71	71	CD
cord-306921-3afgpunj	395	9	neuropathogenesis	neuropathogenesis	NNP
cord-306921-3afgpunj	395	10	Fibronectin	Fibronectin	NNP
cord-306921-3afgpunj	395	11	facilitates	facilitate	VBZ
cord-306921-3afgpunj	395	12	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	395	13	71	71	CD
cord-306921-3afgpunj	395	14	infection	infection	NN
cord-306921-3afgpunj	395	15	by	by	IN
cord-306921-3afgpunj	395	16	mediating	mediate	VBG
cord-306921-3afgpunj	395	17	viral	viral	JJ
cord-306921-3afgpunj	395	18	entry	entry	NN
cord-306921-3afgpunj	396	1	Human	human	JJ
cord-306921-3afgpunj	396	2	tryptophanyl	tryptophanyl	NNP
cord-306921-3afgpunj	396	3	-	-	HYPH
cord-306921-3afgpunj	396	4	tRNA	tRNA	NNP
cord-306921-3afgpunj	396	5	synthetase	synthetase	NN
cord-306921-3afgpunj	396	6	is	be	VBZ
cord-306921-3afgpunj	396	7	an	an	DT
cord-306921-3afgpunj	396	8	IFN	IFN	NNP
cord-306921-3afgpunj	396	9	-	-	HYPH
cord-306921-3afgpunj	396	10	γ	γ	NN
cord-306921-3afgpunj	396	11	-	-	HYPH
cord-306921-3afgpunj	396	12	inducible	inducible	JJ
cord-306921-3afgpunj	396	13	entry	entry	NN
cord-306921-3afgpunj	396	14	factor	factor	NN
cord-306921-3afgpunj	396	15	for	for	IN
cord-306921-3afgpunj	396	16	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	396	17	Not	not	RB
cord-306921-3afgpunj	396	18	your	-PRON-	PRP$
cord-306921-3afgpunj	396	19	usual	usual	JJ
cord-306921-3afgpunj	396	20	tRNA	trna	NN
cord-306921-3afgpunj	396	21	synthetase	synthetase	NN
cord-306921-3afgpunj	396	22	:	:	:
cord-306921-3afgpunj	396	23	hWARS	hWARS	NNP
cord-306921-3afgpunj	396	24	serves	serve	VBZ
cord-306921-3afgpunj	396	25	as	as	IN
cord-306921-3afgpunj	396	26	an	an	DT
cord-306921-3afgpunj	396	27	enterovirus	enterovirus	NN
cord-306921-3afgpunj	396	28	entry	entry	NN
cord-306921-3afgpunj	396	29	factor	factor	NN
cord-306921-3afgpunj	397	1	ICAM-5	icam-5	RB
cord-306921-3afgpunj	397	2	/	/	SYM
cord-306921-3afgpunj	397	3	Telencephalin	Telencephalin	NNP
cord-306921-3afgpunj	397	4	is	be	VBZ
cord-306921-3afgpunj	397	5	a	a	DT
cord-306921-3afgpunj	397	6	functional	functional	JJ
cord-306921-3afgpunj	397	7	entry	entry	NN
cord-306921-3afgpunj	397	8	receptor	receptor	NN
cord-306921-3afgpunj	397	9	for	for	IN
cord-306921-3afgpunj	397	10	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	397	11	D68	D68	NNP
cord-306921-3afgpunj	397	12	Sialic	Sialic	NNP
cord-306921-3afgpunj	397	13	aciddependent	aciddependent	NN
cord-306921-3afgpunj	397	14	cell	cell	NN
cord-306921-3afgpunj	397	15	entry	entry	NN
cord-306921-3afgpunj	397	16	of	of	IN
cord-306921-3afgpunj	397	17	human	human	JJ
cord-306921-3afgpunj	397	18	enterovirus	enterovirus	NN
cord-306921-3afgpunj	397	19	D68	D68	NNP
cord-306921-3afgpunj	398	1	The	the	DT
cord-306921-3afgpunj	398	2	murine	murine	JJ
cord-306921-3afgpunj	398	3	CAR	car	NN
cord-306921-3afgpunj	398	4	homolog	homolog	NN
cord-306921-3afgpunj	398	5	is	be	VBZ
cord-306921-3afgpunj	398	6	a	a	DT
cord-306921-3afgpunj	398	7	receptor	receptor	NN
cord-306921-3afgpunj	398	8	for	for	IN
cord-306921-3afgpunj	398	9	coxsackie	coxsackie	NNP
cord-306921-3afgpunj	398	10	B	B	NNP
cord-306921-3afgpunj	398	11	viruses	virus	NNS
cord-306921-3afgpunj	398	12	and	and	CC
cord-306921-3afgpunj	398	13	adenoviruses	adenovirus	NNS
cord-306921-3afgpunj	399	1	The	the	DT
cord-306921-3afgpunj	399	2	coxsackievirus	coxsackievirus	NN
cord-306921-3afgpunj	399	3	-	-	HYPH
cord-306921-3afgpunj	399	4	adenovirus	adenovirus	NN
cord-306921-3afgpunj	399	5	receptor	receptor	NN
cord-306921-3afgpunj	399	6	protein	protein	NN
cord-306921-3afgpunj	399	7	can	can	MD
cord-306921-3afgpunj	399	8	function	function	VB
cord-306921-3afgpunj	399	9	as	as	IN
cord-306921-3afgpunj	399	10	a	a	DT
cord-306921-3afgpunj	399	11	cellular	cellular	JJ
cord-306921-3afgpunj	399	12	attachment	attachment	NN
cord-306921-3afgpunj	399	13	protein	protein	NN
cord-306921-3afgpunj	399	14	for	for	IN
cord-306921-3afgpunj	399	15	adenovirus	adenovirus	NN
cord-306921-3afgpunj	399	16	serotypes	serotype	NNS
cord-306921-3afgpunj	399	17	from	from	IN
cord-306921-3afgpunj	399	18	subgroups	subgroup	NNS
cord-306921-3afgpunj	400	1	A	a	DT
cord-306921-3afgpunj	400	2	Role	role	NN
cord-306921-3afgpunj	400	3	of	of	IN
cord-306921-3afgpunj	400	4	enhanced	enhance	VBN
cord-306921-3afgpunj	400	5	receptor	receptor	NN
cord-306921-3afgpunj	400	6	engagement	engagement	NN
cord-306921-3afgpunj	400	7	in	in	IN
cord-306921-3afgpunj	400	8	the	the	DT
cord-306921-3afgpunj	400	9	evolution	evolution	NN
cord-306921-3afgpunj	400	10	of	of	IN
cord-306921-3afgpunj	400	11	a	a	DT
cord-306921-3afgpunj	400	12	pandemic	pandemic	JJ
cord-306921-3afgpunj	400	13	acute	acute	JJ
cord-306921-3afgpunj	400	14	hemorrhagic	hemorrhagic	JJ
cord-306921-3afgpunj	400	15	conjunctivitis	conjunctivitis	NN
cord-306921-3afgpunj	400	16	virus	virus	NN
cord-306921-3afgpunj	400	17	Members	member	NNS
cord-306921-3afgpunj	400	18	of	of	IN
cord-306921-3afgpunj	400	19	the	the	DT
cord-306921-3afgpunj	400	20	low	low	JJ
cord-306921-3afgpunj	400	21	density	density	NN
cord-306921-3afgpunj	400	22	lipoprotein	lipoprotein	NN
cord-306921-3afgpunj	400	23	receptor	receptor	NN
cord-306921-3afgpunj	400	24	family	family	NN
cord-306921-3afgpunj	400	25	mediate	mediate	VB
cord-306921-3afgpunj	400	26	cell	cell	NN
cord-306921-3afgpunj	400	27	entry	entry	NN
cord-306921-3afgpunj	400	28	of	of	IN
cord-306921-3afgpunj	400	29	a	a	DT
cord-306921-3afgpunj	400	30	minor	minor	JJ
cord-306921-3afgpunj	400	31	-	-	HYPH
cord-306921-3afgpunj	400	32	group	group	NN
cord-306921-3afgpunj	400	33	common	common	JJ
cord-306921-3afgpunj	400	34	cold	cold	JJ
cord-306921-3afgpunj	400	35	virus	virus	NN
cord-306921-3afgpunj	400	36	Avian	avian	JJ
cord-306921-3afgpunj	400	37	homologs	homolog	NNS
cord-306921-3afgpunj	400	38	of	of	IN
cord-306921-3afgpunj	400	39	the	the	DT
cord-306921-3afgpunj	400	40	mammalian	mammalian	JJ
cord-306921-3afgpunj	400	41	low	low	JJ
cord-306921-3afgpunj	400	42	-	-	HYPH
cord-306921-3afgpunj	400	43	density	density	NN
cord-306921-3afgpunj	400	44	lipoprotein	lipoprotein	NN
cord-306921-3afgpunj	400	45	receptor	receptor	NN
cord-306921-3afgpunj	400	46	family	family	NN
cord-306921-3afgpunj	400	47	bind	bind	VB
cord-306921-3afgpunj	401	1	minor	minor	JJ
cord-306921-3afgpunj	401	2	receptor	receptor	NN
cord-306921-3afgpunj	401	3	group	group	NN
cord-306921-3afgpunj	401	4	human	human	JJ
cord-306921-3afgpunj	401	5	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	401	6	Mouse	Mouse	NNP
cord-306921-3afgpunj	401	7	cells	cell	NNS
cord-306921-3afgpunj	401	8	expressing	express	VBG
cord-306921-3afgpunj	401	9	human	human	JJ
cord-306921-3afgpunj	401	10	intercellular	intercellular	JJ
cord-306921-3afgpunj	401	11	adhesion	adhesion	NN
cord-306921-3afgpunj	401	12	molecule-1	molecule-1	NNP
cord-306921-3afgpunj	401	13	are	be	VBP
cord-306921-3afgpunj	401	14	susceptible	susceptible	JJ
cord-306921-3afgpunj	401	15	to	to	IN
cord-306921-3afgpunj	401	16	infection	infection	NN
cord-306921-3afgpunj	401	17	by	by	IN
cord-306921-3afgpunj	401	18	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	401	19	A21	A21	NNP
cord-306921-3afgpunj	401	20	KREMEN1	KREMEN1	NNP
cord-306921-3afgpunj	402	1	Is	be	VBZ
cord-306921-3afgpunj	402	2	a	a	DT
cord-306921-3afgpunj	402	3	Host	Host	NNP
cord-306921-3afgpunj	402	4	Entry	Entry	NNP
cord-306921-3afgpunj	402	5	Receptor	Receptor	NNP
cord-306921-3afgpunj	402	6	for	for	IN
cord-306921-3afgpunj	402	7	a	a	DT
cord-306921-3afgpunj	402	8	Major	Major	NNP
cord-306921-3afgpunj	402	9	Group	Group	NNP
cord-306921-3afgpunj	402	10	of	of	IN
cord-306921-3afgpunj	402	11	Enteroviruses	Enteroviruses	NNP
cord-306921-3afgpunj	402	12	Cadherin	Cadherin	NNP
cord-306921-3afgpunj	402	13	-	-	HYPH
cord-306921-3afgpunj	402	14	related	relate	VBN
cord-306921-3afgpunj	402	15	family	family	NN
cord-306921-3afgpunj	402	16	member	member	NN
cord-306921-3afgpunj	402	17	3	3	CD
cord-306921-3afgpunj	402	18	,	,	,
cord-306921-3afgpunj	402	19	a	a	DT
cord-306921-3afgpunj	402	20	childhood	childhood	NN
cord-306921-3afgpunj	402	21	asthma	asthma	NN
cord-306921-3afgpunj	402	22	susceptibility	susceptibility	NN
cord-306921-3afgpunj	402	23	gene	gene	NN
cord-306921-3afgpunj	402	24	product	product	NN
cord-306921-3afgpunj	402	25	,	,	,
cord-306921-3afgpunj	402	26	mediates	mediate	VBZ
cord-306921-3afgpunj	402	27	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	402	28	C	c	NN
cord-306921-3afgpunj	402	29	binding	binding	NN
cord-306921-3afgpunj	402	30	and	and	CC
cord-306921-3afgpunj	402	31	replication	replication	NN
cord-306921-3afgpunj	403	1	The	the	DT
cord-306921-3afgpunj	403	2	major	major	JJ
cord-306921-3afgpunj	403	3	and	and	CC
cord-306921-3afgpunj	403	4	minor	minor	JJ
cord-306921-3afgpunj	403	5	group	group	NN
cord-306921-3afgpunj	403	6	receptor	receptor	NN
cord-306921-3afgpunj	403	7	families	family	NNS
cord-306921-3afgpunj	403	8	contain	contain	VBP
cord-306921-3afgpunj	403	9	all	all	DT
cord-306921-3afgpunj	403	10	but	but	IN
cord-306921-3afgpunj	403	11	one	one	CD
cord-306921-3afgpunj	403	12	human	human	JJ
cord-306921-3afgpunj	403	13	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	403	14	serotype	serotype	NN
cord-306921-3afgpunj	403	15	Decayaccelerating	Decayaccelerating	NNP
cord-306921-3afgpunj	403	16	factor	factor	NN
cord-306921-3afgpunj	403	17	(	(	-LRB-
cord-306921-3afgpunj	403	18	CD55	CD55	NNP
cord-306921-3afgpunj	403	19	)	)	-RRB-
cord-306921-3afgpunj	403	20	,	,	,
cord-306921-3afgpunj	403	21	a	a	DT
cord-306921-3afgpunj	403	22	glycosylphosphatidylinositol	glycosylphosphatidylinositol	NN
cord-306921-3afgpunj	403	23	-	-	HYPH
cord-306921-3afgpunj	403	24	anchored	anchor	VBN
cord-306921-3afgpunj	403	25	complement	complement	NN
cord-306921-3afgpunj	403	26	regulatory	regulatory	JJ
cord-306921-3afgpunj	403	27	protein	protein	NN
cord-306921-3afgpunj	403	28	,	,	,
cord-306921-3afgpunj	403	29	is	be	VBZ
cord-306921-3afgpunj	403	30	a	a	DT
cord-306921-3afgpunj	403	31	receptor	receptor	NN
cord-306921-3afgpunj	403	32	for	for	IN
cord-306921-3afgpunj	403	33	several	several	JJ
cord-306921-3afgpunj	403	34	echoviruses	echovirus	NNS
cord-306921-3afgpunj	403	35	Interaction	Interaction	NNP
cord-306921-3afgpunj	403	36	with	with	IN
cord-306921-3afgpunj	403	37	decay	decay	NN
cord-306921-3afgpunj	403	38	-	-	HYPH
cord-306921-3afgpunj	403	39	accelerating	accelerate	VBG
cord-306921-3afgpunj	403	40	factor	factor	NN
cord-306921-3afgpunj	403	41	facilitates	facilitate	VBZ
cord-306921-3afgpunj	403	42	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	403	43	B	B	NNP
cord-306921-3afgpunj	403	44	infection	infection	NN
cord-306921-3afgpunj	403	45	of	of	IN
cord-306921-3afgpunj	403	46	polarized	polarized	JJ
cord-306921-3afgpunj	403	47	epithelial	epithelial	JJ
cord-306921-3afgpunj	403	48	cells	cell	NNS
cord-306921-3afgpunj	403	49	Characterization	characterization	NN
cord-306921-3afgpunj	403	50	of	of	IN
cord-306921-3afgpunj	403	51	echoviruses	echovirus	NNS
cord-306921-3afgpunj	403	52	that	that	WDT
cord-306921-3afgpunj	403	53	bind	bind	VBP
cord-306921-3afgpunj	403	54	decay	decay	NN
cord-306921-3afgpunj	403	55	accelerating	accelerate	VBG
cord-306921-3afgpunj	403	56	factor	factor	NN
cord-306921-3afgpunj	403	57	(	(	-LRB-
cord-306921-3afgpunj	403	58	CD55	CD55	NNP
cord-306921-3afgpunj	403	59	)	)	-RRB-
cord-306921-3afgpunj	403	60	:	:	:
cord-306921-3afgpunj	403	61	evidence	evidence	NN
cord-306921-3afgpunj	403	62	that	that	IN
cord-306921-3afgpunj	403	63	some	some	DT
cord-306921-3afgpunj	403	64	haemagglutinating	haemagglutinating	NN
cord-306921-3afgpunj	403	65	strains	strain	NNS
cord-306921-3afgpunj	403	66	use	use	VBP
cord-306921-3afgpunj	403	67	more	more	JJR
cord-306921-3afgpunj	403	68	than	than	IN
cord-306921-3afgpunj	403	69	one	one	CD
cord-306921-3afgpunj	403	70	cellular	cellular	JJ
cord-306921-3afgpunj	403	71	receptor	receptor	NN
cord-306921-3afgpunj	403	72	Tyrosine	Tyrosine	NNP
cord-306921-3afgpunj	403	73	Sulfation	Sulfation	NNP
cord-306921-3afgpunj	403	74	of	of	IN
cord-306921-3afgpunj	403	75	the	the	DT
cord-306921-3afgpunj	403	76	amino	amino	NN
cord-306921-3afgpunj	403	77	terminus	terminus	NN
cord-306921-3afgpunj	403	78	of	of	IN
cord-306921-3afgpunj	403	79	PSGL-1	PSGL-1	NNP
cord-306921-3afgpunj	403	80	is	be	VBZ
cord-306921-3afgpunj	403	81	critical	critical	JJ
cord-306921-3afgpunj	403	82	for	for	IN
cord-306921-3afgpunj	403	83	Enterovirus	enterovirus	NN
cord-306921-3afgpunj	403	84	71	71	CD
cord-306921-3afgpunj	403	85	infection	infection	NN
cord-306921-3afgpunj	404	1	A	a	DT
cord-306921-3afgpunj	404	2	genome	genome	NN
cord-306921-3afgpunj	404	3	-	-	HYPH
cord-306921-3afgpunj	404	4	wide	wide	JJ
cord-306921-3afgpunj	404	5	RNAi	RNAi	NNS
cord-306921-3afgpunj	404	6	screening	screening	NN
cord-306921-3afgpunj	404	7	method	method	NN
cord-306921-3afgpunj	404	8	to	to	TO
cord-306921-3afgpunj	404	9	discover	discover	VB
cord-306921-3afgpunj	404	10	novel	novel	JJ
cord-306921-3afgpunj	404	11	genes	gene	NNS
cord-306921-3afgpunj	404	12	involved	involve	VBN
cord-306921-3afgpunj	404	13	in	in	IN
cord-306921-3afgpunj	404	14	virus	virus	NN
cord-306921-3afgpunj	404	15	infection	infection	NN
cord-306921-3afgpunj	404	16	Human	human	JJ
cord-306921-3afgpunj	404	17	genome	genome	NN
cord-306921-3afgpunj	404	18	-	-	HYPH
cord-306921-3afgpunj	404	19	wide	wide	JJ
cord-306921-3afgpunj	404	20	RNAi	RNAi	NNS
cord-306921-3afgpunj	404	21	screen	screen	NN
cord-306921-3afgpunj	404	22	reveals	reveal	VBZ
cord-306921-3afgpunj	404	23	host	host	NN
cord-306921-3afgpunj	404	24	factors	factor	NNS
cord-306921-3afgpunj	404	25	required	require	VBN
cord-306921-3afgpunj	404	26	for	for	IN
cord-306921-3afgpunj	404	27	enterovirus	enterovirus	NN
cord-306921-3afgpunj	404	28	71	71	CD
cord-306921-3afgpunj	404	29	replication	replication	NN
cord-306921-3afgpunj	404	30	Valosin	Valosin	NNP
cord-306921-3afgpunj	404	31	-	-	HYPH
cord-306921-3afgpunj	404	32	containing	contain	VBG
cord-306921-3afgpunj	404	33	protein	protein	NN
cord-306921-3afgpunj	404	34	(	(	-LRB-
cord-306921-3afgpunj	404	35	VCP	VCP	NNP
cord-306921-3afgpunj	404	36	/	/	SYM
cord-306921-3afgpunj	404	37	p97	p97	CD
cord-306921-3afgpunj	404	38	)	)	-RRB-
cord-306921-3afgpunj	404	39	is	be	VBZ
cord-306921-3afgpunj	404	40	required	require	VBN
cord-306921-3afgpunj	404	41	for	for	IN
cord-306921-3afgpunj	404	42	poliovirus	poliovirus	NN
cord-306921-3afgpunj	404	43	replication	replication	NN
cord-306921-3afgpunj	404	44	and	and	CC
cord-306921-3afgpunj	404	45	is	be	VBZ
cord-306921-3afgpunj	404	46	involved	involve	VBN
cord-306921-3afgpunj	404	47	in	in	IN
cord-306921-3afgpunj	404	48	cellular	cellular	JJ
cord-306921-3afgpunj	404	49	protein	protein	NN
cord-306921-3afgpunj	404	50	secretion	secretion	NN
cord-306921-3afgpunj	404	51	pathway	pathway	NN
cord-306921-3afgpunj	404	52	in	in	IN
cord-306921-3afgpunj	404	53	poliovirus	poliovirus	NN
cord-306921-3afgpunj	404	54	infection	infection	NN
cord-306921-3afgpunj	404	55	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	404	56	71	71	CD
cord-306921-3afgpunj	404	57	protease	protease	NN
cord-306921-3afgpunj	404	58	2Apro	2Apro	NNP
cord-306921-3afgpunj	404	59	and	and	CC
cord-306921-3afgpunj	404	60	3Cpro	3Cpro	NNP
cord-306921-3afgpunj	404	61	differentially	differentially	RB
cord-306921-3afgpunj	404	62	inhibit	inhibit	VB
cord-306921-3afgpunj	404	63	the	the	DT
cord-306921-3afgpunj	404	64	cellular	cellular	JJ
cord-306921-3afgpunj	404	65	endoplasmic	endoplasmic	NN
cord-306921-3afgpunj	404	66	reticulum	reticulum	NN
cord-306921-3afgpunj	404	67	-	-	HYPH
cord-306921-3afgpunj	404	68	associated	associate	VBN
cord-306921-3afgpunj	404	69	degradation	degradation	NN
cord-306921-3afgpunj	404	70	(	(	-LRB-
cord-306921-3afgpunj	404	71	ERAD	ERAD	NNP
cord-306921-3afgpunj	404	72	)	)	-RRB-
cord-306921-3afgpunj	404	73	pathway	pathway	NN
cord-306921-3afgpunj	404	74	via	via	IN
cord-306921-3afgpunj	404	75	distinct	distinct	JJ
cord-306921-3afgpunj	404	76	mechanisms	mechanism	NNS
cord-306921-3afgpunj	404	77	,	,	,
cord-306921-3afgpunj	404	78	and	and	CC
cord-306921-3afgpunj	404	79	enterovirus	enterovirus	NN
cord-306921-3afgpunj	404	80	71	71	CD
cord-306921-3afgpunj	404	81	hijacks	hijack	VBZ
cord-306921-3afgpunj	404	82	ERAD	ERAD	NNP
cord-306921-3afgpunj	404	83	component	component	NN
cord-306921-3afgpunj	404	84	p97	p97	CD
cord-306921-3afgpunj	404	85	to	to	TO
cord-306921-3afgpunj	404	86	promote	promote	VB
cord-306921-3afgpunj	404	87	its	-PRON-	PRP$
cord-306921-3afgpunj	404	88	replication	replication	NN
cord-306921-3afgpunj	404	89	Cellular	Cellular	NNP
cord-306921-3afgpunj	404	90	N	N	NNP
cord-306921-3afgpunj	404	91	-	-	HYPH
cord-306921-3afgpunj	404	92	myristoyltransferases	myristoyltransferase	NNS
cord-306921-3afgpunj	404	93	play	play	VBP
cord-306921-3afgpunj	404	94	a	a	DT
cord-306921-3afgpunj	404	95	crucial	crucial	JJ
cord-306921-3afgpunj	404	96	picornavirus	picornavirus	NN
cord-306921-3afgpunj	404	97	genus	genus	NN
cord-306921-3afgpunj	404	98	-	-	HYPH
cord-306921-3afgpunj	404	99	specific	specific	JJ
cord-306921-3afgpunj	404	100	role	role	NN
cord-306921-3afgpunj	404	101	in	in	IN
cord-306921-3afgpunj	404	102	viral	viral	JJ
cord-306921-3afgpunj	404	103	assembly	assembly	NN
cord-306921-3afgpunj	404	104	,	,	,
cord-306921-3afgpunj	404	105	virion	virion	NN
cord-306921-3afgpunj	404	106	maturation	maturation	NN
cord-306921-3afgpunj	404	107	,	,	,
cord-306921-3afgpunj	404	108	and	and	CC
cord-306921-3afgpunj	404	109	infectivity	infectivity	NN
cord-306921-3afgpunj	404	110	Inhibition	inhibition	NN
cord-306921-3afgpunj	404	111	of	of	IN
cord-306921-3afgpunj	404	112	enterovirus	enterovirus	NN
cord-306921-3afgpunj	404	113	VP4	vp4	JJ
cord-306921-3afgpunj	404	114	myristoylation	myristoylation	NN
cord-306921-3afgpunj	404	115	is	be	VBZ
cord-306921-3afgpunj	404	116	a	a	DT
cord-306921-3afgpunj	404	117	potential	potential	JJ
cord-306921-3afgpunj	404	118	antiviral	antiviral	JJ
cord-306921-3afgpunj	404	119	strategy	strategy	NN
cord-306921-3afgpunj	404	120	for	for	IN
cord-306921-3afgpunj	404	121	hand	hand	NN
cord-306921-3afgpunj	404	122	,	,	,
cord-306921-3afgpunj	404	123	foot	foot	NN
cord-306921-3afgpunj	404	124	and	and	CC
cord-306921-3afgpunj	404	125	mouth	mouth	NN
cord-306921-3afgpunj	404	126	disease	disease	NN
cord-306921-3afgpunj	405	1	How	how	WRB
cord-306921-3afgpunj	405	2	RNA	RNA	NNP
cord-306921-3afgpunj	405	3	viruses	virus	NNS
cord-306921-3afgpunj	405	4	maintain	maintain	VBP
cord-306921-3afgpunj	405	5	their	-PRON-	PRP$
cord-306921-3afgpunj	405	6	genome	genome	NN
cord-306921-3afgpunj	405	7	integrity	integrity	NN
cord-306921-3afgpunj	405	8	Fat(al	Fat(al	NNP
cord-306921-3afgpunj	405	9	)	)	-RRB-
cord-306921-3afgpunj	405	10	attraction	attraction	NN
cord-306921-3afgpunj	405	11	:	:	:
cord-306921-3afgpunj	406	1	picornaviruses	picornaviruses	NNP
cord-306921-3afgpunj	406	2	usurp	usurp	VBP
cord-306921-3afgpunj	406	3	lipid	lipid	NN
cord-306921-3afgpunj	406	4	transfer	transfer	NN
cord-306921-3afgpunj	406	5	at	at	IN
cord-306921-3afgpunj	406	6	membrane	membrane	NN
cord-306921-3afgpunj	406	7	contact	contact	NN
cord-306921-3afgpunj	406	8	sites	site	NNS
cord-306921-3afgpunj	406	9	to	to	TO
cord-306921-3afgpunj	406	10	create	create	VB
cord-306921-3afgpunj	406	11	replication	replication	NN
cord-306921-3afgpunj	406	12	organelles	organelle	NNS
cord-306921-3afgpunj	407	1	Hepatitis	Hepatitis	NNP
cord-306921-3afgpunj	407	2	C	C	NNP
cord-306921-3afgpunj	407	3	virus	virus	NN
cord-306921-3afgpunj	407	4	replication	replication	NN
cord-306921-3afgpunj	407	5	depends	depend	VBZ
cord-306921-3afgpunj	407	6	on	on	IN
cord-306921-3afgpunj	407	7	endosomal	endosomal	NNP
cord-306921-3afgpunj	407	8	cholesterol	cholesterol	NN
cord-306921-3afgpunj	407	9	homeostasis	homeostasis	NN
cord-306921-3afgpunj	407	10	Viral	viral	JJ
cord-306921-3afgpunj	407	11	reorganization	reorganization	NN
cord-306921-3afgpunj	407	12	of	of	IN
cord-306921-3afgpunj	407	13	the	the	DT
cord-306921-3afgpunj	407	14	secretory	secretory	JJ
cord-306921-3afgpunj	407	15	pathway	pathway	NN
cord-306921-3afgpunj	407	16	generates	generate	VBZ
cord-306921-3afgpunj	407	17	distinct	distinct	JJ
cord-306921-3afgpunj	407	18	organelles	organelle	NNS
cord-306921-3afgpunj	407	19	for	for	IN
cord-306921-3afgpunj	407	20	RNA	rna	NN
cord-306921-3afgpunj	407	21	replication	replication	NN
cord-306921-3afgpunj	407	22	ARF1	ARF1	NNP
cord-306921-3afgpunj	407	23	and	and	CC
cord-306921-3afgpunj	407	24	GBF1	GBF1	NNP
cord-306921-3afgpunj	407	25	generate	generate	VB
cord-306921-3afgpunj	407	26	a	a	DT
cord-306921-3afgpunj	407	27	PI4P	PI4P	VBN
cord-306921-3afgpunj	407	28	-	-	HYPH
cord-306921-3afgpunj	407	29	enriched	enrich	VBN
cord-306921-3afgpunj	407	30	environment	environment	NN
cord-306921-3afgpunj	407	31	supportive	supportive	JJ
cord-306921-3afgpunj	407	32	of	of	IN
cord-306921-3afgpunj	407	33	hepatitis	hepatitis	NNP
cord-306921-3afgpunj	407	34	C	C	NNP
cord-306921-3afgpunj	407	35	virus	virus	NN
cord-306921-3afgpunj	407	36	replication	replication	NN
cord-306921-3afgpunj	407	37	Recruitment	Recruitment	NNP
cord-306921-3afgpunj	407	38	of	of	IN
cord-306921-3afgpunj	407	39	PI4KIII	PI4KIII	NNP
cord-306921-3afgpunj	407	40	to	to	IN
cord-306921-3afgpunj	407	41	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	407	42	B3	b3	NN
cord-306921-3afgpunj	407	43	replication	replication	NN
cord-306921-3afgpunj	407	44	organelles	organelle	NNS
cord-306921-3afgpunj	407	45	is	be	VBZ
cord-306921-3afgpunj	407	46	independent	independent	JJ
cord-306921-3afgpunj	407	47	of	of	IN
cord-306921-3afgpunj	407	48	ACBD3	acbd3	NN
cord-306921-3afgpunj	407	49	,	,	,
cord-306921-3afgpunj	407	50	GBF1	GBF1	NNP
cord-306921-3afgpunj	407	51	,	,	,
cord-306921-3afgpunj	407	52	and	and	CC
cord-306921-3afgpunj	407	53	Arf1	Arf1	NNP
cord-306921-3afgpunj	407	54	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	407	55	3A	3a	NN
cord-306921-3afgpunj	407	56	facilitates	facilitate	VBZ
cord-306921-3afgpunj	407	57	viral	viral	JJ
cord-306921-3afgpunj	407	58	replication	replication	NN
cord-306921-3afgpunj	407	59	by	by	IN
cord-306921-3afgpunj	407	60	promoting	promote	VBG
cord-306921-3afgpunj	407	61	PI4KB	PI4KB	NNP
cord-306921-3afgpunj	407	62	-	-	HYPH
cord-306921-3afgpunj	407	63	ACBD3	acbd3	NN
cord-306921-3afgpunj	407	64	interaction	interaction	NN
cord-306921-3afgpunj	407	65	Hijacking	hijacking	NN
cord-306921-3afgpunj	407	66	of	of	IN
cord-306921-3afgpunj	407	67	multiple	multiple	JJ
cord-306921-3afgpunj	407	68	phospholipid	phospholipid	NN
cord-306921-3afgpunj	407	69	biosynthetic	biosynthetic	JJ
cord-306921-3afgpunj	407	70	pathways	pathway	NNS
cord-306921-3afgpunj	407	71	and	and	CC
cord-306921-3afgpunj	407	72	induction	induction	NN
cord-306921-3afgpunj	407	73	of	of	IN
cord-306921-3afgpunj	407	74	membrane	membrane	NN
cord-306921-3afgpunj	407	75	biogenesis	biogenesis	NN
cord-306921-3afgpunj	407	76	by	by	IN
cord-306921-3afgpunj	407	77	a	a	DT
cord-306921-3afgpunj	407	78	picornaviral	picornaviral	JJ
cord-306921-3afgpunj	407	79	3CD	3CD	NNP
cord-306921-3afgpunj	407	80	protein	protein	NN
cord-306921-3afgpunj	408	1	The	the	DT
cord-306921-3afgpunj	408	2	origin	origin	NN
cord-306921-3afgpunj	408	3	,	,	,
cord-306921-3afgpunj	408	4	dynamic	dynamic	JJ
cord-306921-3afgpunj	408	5	morphology	morphology	NN
cord-306921-3afgpunj	408	6	,	,	,
cord-306921-3afgpunj	408	7	and	and	CC
cord-306921-3afgpunj	408	8	PI4P	pi4p	JJ
cord-306921-3afgpunj	408	9	-	-	JJ
cord-306921-3afgpunj	408	10	independent	independent	JJ
cord-306921-3afgpunj	408	11	formation	formation	NN
cord-306921-3afgpunj	408	12	of	of	IN
cord-306921-3afgpunj	408	13	Encephalomyocarditis	Encephalomyocarditis	NNP
cord-306921-3afgpunj	408	14	virus	virus	NN
cord-306921-3afgpunj	408	15	replication	replication	NN
cord-306921-3afgpunj	408	16	organelles	organelle	NNS
cord-306921-3afgpunj	408	17	Escaping	escape	VBG
cord-306921-3afgpunj	408	18	host	host	NN
cord-306921-3afgpunj	408	19	factor	factor	NN
cord-306921-3afgpunj	409	1	PI4	PI4	NNP
cord-306921-3afgpunj	409	2	KB	KB	NNP
cord-306921-3afgpunj	409	3	inhibition	inhibition	NN
cord-306921-3afgpunj	409	4	:	:	:
cord-306921-3afgpunj	409	5	Enterovirus	enterovirus	NN
cord-306921-3afgpunj	409	6	genomic	genomic	JJ
cord-306921-3afgpunj	409	7	RNA	rna	NN
cord-306921-3afgpunj	409	8	replication	replication	NN
cord-306921-3afgpunj	409	9	in	in	IN
cord-306921-3afgpunj	409	10	the	the	DT
cord-306921-3afgpunj	409	11	absence	absence	NN
cord-306921-3afgpunj	409	12	of	of	IN
cord-306921-3afgpunj	409	13	replication	replication	NN
cord-306921-3afgpunj	409	14	organelles	organelle	NNS
cord-306921-3afgpunj	410	1	A	a	DT
cord-306921-3afgpunj	410	2	novel	novel	NN
cord-306921-3afgpunj	410	3	,	,	,
cord-306921-3afgpunj	410	4	broad	broad	JJ
cord-306921-3afgpunj	410	5	-	-	HYPH
cord-306921-3afgpunj	410	6	Spectrum	Spectrum	NNP
cord-306921-3afgpunj	410	7	inhibitor	inhibitor	NN
cord-306921-3afgpunj	410	8	of	of	IN
cord-306921-3afgpunj	410	9	Enterovirus	enterovirus	NN
cord-306921-3afgpunj	410	10	replication	replication	NN
cord-306921-3afgpunj	410	11	that	that	WDT
cord-306921-3afgpunj	410	12	targets	target	VBZ
cord-306921-3afgpunj	410	13	host	host	NN
cord-306921-3afgpunj	410	14	cell	cell	NN
cord-306921-3afgpunj	410	15	factor	factor	NN
cord-306921-3afgpunj	410	16	phosphatidylinositol	phosphatidylinositol	JJ
cord-306921-3afgpunj	410	17	4-kinase	4-kinase	CD
cord-306921-3afgpunj	410	18	IIIβ	IIIβ	NNS
cord-306921-3afgpunj	410	19	Host	Host	NNP
cord-306921-3afgpunj	410	20	lipidome	lipidome	NN
cord-306921-3afgpunj	410	21	analysis	analysis	NN
cord-306921-3afgpunj	410	22	during	during	IN
cord-306921-3afgpunj	410	23	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	410	24	replication	replication	NN
cord-306921-3afgpunj	410	25	in	in	IN
cord-306921-3afgpunj	410	26	HBECs	HBECs	NNP
cord-306921-3afgpunj	410	27	identifies	identify	VBZ
cord-306921-3afgpunj	410	28	potential	potential	JJ
cord-306921-3afgpunj	410	29	therapeutic	therapeutic	JJ
cord-306921-3afgpunj	410	30	targets	target	NNS
cord-306921-3afgpunj	410	31	Nucleo	nucleo	JJ
cord-306921-3afgpunj	410	32	-	-	HYPH
cord-306921-3afgpunj	410	33	cytoplasmic	cytoplasmic	JJ
cord-306921-3afgpunj	410	34	distribution	distribution	NN
cord-306921-3afgpunj	410	35	of	of	IN
cord-306921-3afgpunj	410	36	human	human	JJ
cord-306921-3afgpunj	410	37	hnRNP	hnrnp	NN
cord-306921-3afgpunj	410	38	proteins	protein	NNS
cord-306921-3afgpunj	410	39	:	:	:
cord-306921-3afgpunj	410	40	a	a	DT
cord-306921-3afgpunj	410	41	search	search	NN
cord-306921-3afgpunj	410	42	for	for	IN
cord-306921-3afgpunj	410	43	the	the	DT
cord-306921-3afgpunj	410	44	targeting	target	VBG
cord-306921-3afgpunj	410	45	domains	domain	NNS
cord-306921-3afgpunj	410	46	in	in	IN
cord-306921-3afgpunj	410	47	hnRNP	hnrnp	NN
cord-306921-3afgpunj	411	1	A1	A1	NNP
cord-306921-3afgpunj	411	2	A	a	DT
cord-306921-3afgpunj	411	3	nuclear	nuclear	JJ
cord-306921-3afgpunj	411	4	localization	localization	NN
cord-306921-3afgpunj	411	5	domain	domain	NN
cord-306921-3afgpunj	411	6	in	in	IN
cord-306921-3afgpunj	411	7	the	the	DT
cord-306921-3afgpunj	411	8	hnRNP	hnRNP	NNP
cord-306921-3afgpunj	411	9	A1	a1	NN
cord-306921-3afgpunj	411	10	protein	protein	NN
cord-306921-3afgpunj	411	11	hnRNP	hnrnp	DT
cord-306921-3afgpunj	411	12	A1	A1	NNP
cord-306921-3afgpunj	411	13	interacts	interact	VBZ
cord-306921-3afgpunj	411	14	with	with	IN
cord-306921-3afgpunj	411	15	the	the	DT
cord-306921-3afgpunj	411	16	5′	5′	CD
cord-306921-3afgpunj	411	17	untranslated	untranslated	JJ
cord-306921-3afgpunj	411	18	regions	region	NNS
cord-306921-3afgpunj	411	19	of	of	IN
cord-306921-3afgpunj	411	20	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	411	21	71	71	CD
cord-306921-3afgpunj	411	22	and	and	CC
cord-306921-3afgpunj	411	23	Sindbis	Sindbis	NNP
cord-306921-3afgpunj	411	24	virus	virus	NN
cord-306921-3afgpunj	411	25	RNA	RNA	NNP
cord-306921-3afgpunj	411	26	and	and	CC
cord-306921-3afgpunj	411	27	is	be	VBZ
cord-306921-3afgpunj	411	28	required	require	VBN
cord-306921-3afgpunj	411	29	for	for	IN
cord-306921-3afgpunj	411	30	viral	viral	JJ
cord-306921-3afgpunj	411	31	replication	replication	NN
cord-306921-3afgpunj	411	32	High	high	JJ
cord-306921-3afgpunj	411	33	-	-	HYPH
cord-306921-3afgpunj	411	34	affinity	affinity	NN
cord-306921-3afgpunj	411	35	interaction	interaction	NN
cord-306921-3afgpunj	411	36	of	of	IN
cord-306921-3afgpunj	411	37	hnRNP	hnrnp	DT
cord-306921-3afgpunj	411	38	A1	A1	NNP
cord-306921-3afgpunj	411	39	with	with	IN
cord-306921-3afgpunj	411	40	conserved	conserve	VBN
cord-306921-3afgpunj	411	41	RNA	RNA	NNP
cord-306921-3afgpunj	411	42	structural	structural	JJ
cord-306921-3afgpunj	411	43	elements	element	NNS
cord-306921-3afgpunj	411	44	is	be	VBZ
cord-306921-3afgpunj	411	45	required	require	VBN
cord-306921-3afgpunj	411	46	for	for	IN
cord-306921-3afgpunj	411	47	translation	translation	NN
cord-306921-3afgpunj	411	48	and	and	CC
cord-306921-3afgpunj	411	49	replication	replication	NN
cord-306921-3afgpunj	411	50	of	of	IN
cord-306921-3afgpunj	411	51	enterovirus	enterovirus	NN
cord-306921-3afgpunj	411	52	71	71	CD
cord-306921-3afgpunj	412	1	HnRNP	HnRNP	NNP
cord-306921-3afgpunj	412	2	A1	A1	NNP
cord-306921-3afgpunj	412	3	alters	alter	VBZ
cord-306921-3afgpunj	412	4	the	the	DT
cord-306921-3afgpunj	412	5	structure	structure	NN
cord-306921-3afgpunj	412	6	of	of	IN
cord-306921-3afgpunj	412	7	a	a	DT
cord-306921-3afgpunj	412	8	conserved	conserve	VBN
cord-306921-3afgpunj	412	9	Enterovirus	enterovirus	NN
cord-306921-3afgpunj	412	10	IRES	IRES	NNP
cord-306921-3afgpunj	412	11	domain	domain	NN
cord-306921-3afgpunj	412	12	to	to	TO
cord-306921-3afgpunj	412	13	stimulate	stimulate	VB
cord-306921-3afgpunj	412	14	viral	viral	JJ
cord-306921-3afgpunj	412	15	translation	translation	NN
cord-306921-3afgpunj	413	1	A	a	DT
cord-306921-3afgpunj	413	2	peptide	peptide	NN
cord-306921-3afgpunj	413	3	from	from	IN
cord-306921-3afgpunj	413	4	autoantigen	autoantigen	NNP
cord-306921-3afgpunj	413	5	La	La	NNP
cord-306921-3afgpunj	413	6	blocks	block	VBZ
cord-306921-3afgpunj	413	7	poliovirus	poliovirus	NN
cord-306921-3afgpunj	413	8	and	and	CC
cord-306921-3afgpunj	413	9	hepatitis	hepatitis	NN
cord-306921-3afgpunj	413	10	C	C	NNP
cord-306921-3afgpunj	413	11	virus	virus	NN
cord-306921-3afgpunj	413	12	cap	cap	NN
cord-306921-3afgpunj	413	13	-	-	HYPH
cord-306921-3afgpunj	413	14	independent	independent	JJ
cord-306921-3afgpunj	413	15	translation	translation	NN
cord-306921-3afgpunj	413	16	and	and	CC
cord-306921-3afgpunj	413	17	reveals	reveal	VBZ
cord-306921-3afgpunj	413	18	a	a	DT
cord-306921-3afgpunj	413	19	single	single	JJ
cord-306921-3afgpunj	413	20	tyrosine	tyrosine	NN
cord-306921-3afgpunj	413	21	critical	critical	JJ
cord-306921-3afgpunj	413	22	for	for	IN
cord-306921-3afgpunj	413	23	La	La	NNP
cord-306921-3afgpunj	413	24	RNA	RNA	NNP
cord-306921-3afgpunj	413	25	binding	binding	NN
cord-306921-3afgpunj	413	26	and	and	CC
cord-306921-3afgpunj	413	27	translation	translation	NN
cord-306921-3afgpunj	413	28	stimulation	stimulation	NN
cord-306921-3afgpunj	414	1	The	the	DT
cord-306921-3afgpunj	414	2	interaction	interaction	NN
cord-306921-3afgpunj	414	3	between	between	IN
cord-306921-3afgpunj	414	4	human	human	JJ
cord-306921-3afgpunj	414	5	Cytomegalovirus	Cytomegalovirus	NNP
cord-306921-3afgpunj	414	6	immediate	immediate	JJ
cord-306921-3afgpunj	414	7	-	-	HYPH
cord-306921-3afgpunj	414	8	early	early	JJ
cord-306921-3afgpunj	414	9	gene	gene	NN
cord-306921-3afgpunj	414	10	2	2	CD
cord-306921-3afgpunj	414	11	(	(	-LRB-
cord-306921-3afgpunj	414	12	IE2	IE2	NNP
cord-306921-3afgpunj	414	13	)	)	-RRB-
cord-306921-3afgpunj	414	14	protein	protein	NN
cord-306921-3afgpunj	414	15	and	and	CC
cord-306921-3afgpunj	414	16	heterogeneous	heterogeneous	JJ
cord-306921-3afgpunj	414	17	ribonucleoprotein	ribonucleoprotein	NN
cord-306921-3afgpunj	414	18	A1	A1	NNP
cord-306921-3afgpunj	414	19	Y	Y	NNP
cord-306921-3afgpunj	414	20	box	box	NN
cord-306921-3afgpunj	414	21	-	-	HYPH
cord-306921-3afgpunj	414	22	binding	bind	VBG
cord-306921-3afgpunj	414	23	protein-1	protein-1	NNP
cord-306921-3afgpunj	414	24	binds	bind	VBZ
cord-306921-3afgpunj	414	25	to	to	IN
cord-306921-3afgpunj	414	26	the	the	DT
cord-306921-3afgpunj	414	27	dengue	dengue	NN
cord-306921-3afgpunj	414	28	virus	virus	NN
cord-306921-3afgpunj	414	29	3′-untranslated	3′-untranslated	CD
cord-306921-3afgpunj	414	30	region	region	NN
cord-306921-3afgpunj	414	31	and	and	CC
cord-306921-3afgpunj	414	32	mediates	mediate	VBZ
cord-306921-3afgpunj	414	33	antiviral	antiviral	JJ
cord-306921-3afgpunj	414	34	effects	effect	NNS
cord-306921-3afgpunj	414	35	Identification	identification	NN
cord-306921-3afgpunj	414	36	of	of	IN
cord-306921-3afgpunj	414	37	an	an	DT
cord-306921-3afgpunj	414	38	hnRNP	hnrnp	NN
cord-306921-3afgpunj	415	1	A1-dependent	a1-dependent	IN
cord-306921-3afgpunj	415	2	splicing	splicing	NN
cord-306921-3afgpunj	415	3	silencer	silencer	NN
cord-306921-3afgpunj	415	4	in	in	IN
cord-306921-3afgpunj	415	5	the	the	DT
cord-306921-3afgpunj	415	6	human	human	JJ
cord-306921-3afgpunj	415	7	papillomavirus	papillomavirus	NN
cord-306921-3afgpunj	415	8	type	type	NN
cord-306921-3afgpunj	415	9	16	16	CD
cord-306921-3afgpunj	415	10	L1	L1	NNP
cord-306921-3afgpunj	415	11	coding	code	VBG
cord-306921-3afgpunj	415	12	region	region	NN
cord-306921-3afgpunj	415	13	that	that	WDT
cord-306921-3afgpunj	415	14	prevents	prevent	VBZ
cord-306921-3afgpunj	415	15	premature	premature	JJ
cord-306921-3afgpunj	415	16	expression	expression	NN
cord-306921-3afgpunj	415	17	of	of	IN
cord-306921-3afgpunj	415	18	the	the	DT
cord-306921-3afgpunj	415	19	late	late	JJ
cord-306921-3afgpunj	415	20	L1	L1	NNP
cord-306921-3afgpunj	415	21	gene	gene	NN
cord-306921-3afgpunj	415	22	Far	far	RB
cord-306921-3afgpunj	415	23	upstream	upstream	JJ
cord-306921-3afgpunj	415	24	element	element	NN
cord-306921-3afgpunj	415	25	binding	bind	VBG
cord-306921-3afgpunj	415	26	protein	protein	NN
cord-306921-3afgpunj	415	27	2	2	CD
cord-306921-3afgpunj	415	28	interacts	interact	VBZ
cord-306921-3afgpunj	415	29	with	with	IN
cord-306921-3afgpunj	415	30	enterovirus	enterovirus	NN
cord-306921-3afgpunj	415	31	71	71	CD
cord-306921-3afgpunj	415	32	internal	internal	JJ
cord-306921-3afgpunj	415	33	ribosomal	ribosomal	NN
cord-306921-3afgpunj	415	34	entry	entry	NN
cord-306921-3afgpunj	415	35	site	site	NN
cord-306921-3afgpunj	415	36	and	and	CC
cord-306921-3afgpunj	415	37	negatively	negatively	RB
cord-306921-3afgpunj	415	38	regulates	regulate	VBZ
cord-306921-3afgpunj	415	39	viral	viral	JJ
cord-306921-3afgpunj	415	40	translation	translation	NN
cord-306921-3afgpunj	416	1	Enterovirus	enterovirus	NN
cord-306921-3afgpunj	416	2	71	71	CD
cord-306921-3afgpunj	416	3	infection	infection	NN
cord-306921-3afgpunj	416	4	cleaves	cleave	VBZ
cord-306921-3afgpunj	416	5	a	a	DT
cord-306921-3afgpunj	416	6	negative	negative	JJ
cord-306921-3afgpunj	416	7	regulator	regulator	NN
cord-306921-3afgpunj	416	8	for	for	IN
cord-306921-3afgpunj	416	9	viral	viral	JJ
cord-306921-3afgpunj	416	10	internal	internal	JJ
cord-306921-3afgpunj	416	11	ribosomal	ribosomal	JJ
cord-306921-3afgpunj	416	12	entry	entry	NN
cord-306921-3afgpunj	416	13	sitedriven	sitedriven	NNP
cord-306921-3afgpunj	416	14	translation	translation	NN
cord-306921-3afgpunj	416	15	Far	far	RB
cord-306921-3afgpunj	416	16	upstream	upstream	JJ
cord-306921-3afgpunj	416	17	element	element	NN
cord-306921-3afgpunj	416	18	binding	bind	VBG
cord-306921-3afgpunj	416	19	protein	protein	NN
cord-306921-3afgpunj	416	20	1	1	CD
cord-306921-3afgpunj	417	1	binds	bind	VBZ
cord-306921-3afgpunj	417	2	the	the	DT
cord-306921-3afgpunj	417	3	internal	internal	JJ
cord-306921-3afgpunj	417	4	ribosomal	ribosomal	JJ
cord-306921-3afgpunj	417	5	entry	entry	NN
cord-306921-3afgpunj	417	6	site	site	NN
cord-306921-3afgpunj	417	7	of	of	IN
cord-306921-3afgpunj	417	8	enterovirus	enterovirus	NN
cord-306921-3afgpunj	417	9	71	71	CD
cord-306921-3afgpunj	417	10	and	and	CC
cord-306921-3afgpunj	417	11	enhances	enhance	VBZ
cord-306921-3afgpunj	417	12	viral	viral	JJ
cord-306921-3afgpunj	417	13	translation	translation	NN
cord-306921-3afgpunj	417	14	and	and	CC
cord-306921-3afgpunj	417	15	viral	viral	JJ
cord-306921-3afgpunj	417	16	growth	growth	NN
cord-306921-3afgpunj	418	1	Nuclear	nuclear	JJ
cord-306921-3afgpunj	418	2	protein	protein	NN
cord-306921-3afgpunj	419	1	Sam68	Sam68	NNP
cord-306921-3afgpunj	419	2	interacts	interact	VBZ
cord-306921-3afgpunj	419	3	with	with	IN
cord-306921-3afgpunj	419	4	the	the	DT
cord-306921-3afgpunj	419	5	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	419	6	71	71	CD
cord-306921-3afgpunj	419	7	internal	internal	JJ
cord-306921-3afgpunj	419	8	ribosome	ribosome	NN
cord-306921-3afgpunj	419	9	entry	entry	NN
cord-306921-3afgpunj	419	10	site	site	NN
cord-306921-3afgpunj	419	11	and	and	CC
cord-306921-3afgpunj	419	12	positively	positively	RB
cord-306921-3afgpunj	419	13	regulates	regulate	VBZ
cord-306921-3afgpunj	419	14	viral	viral	JJ
cord-306921-3afgpunj	419	15	protein	protein	NN
cord-306921-3afgpunj	419	16	translation	translation	NN
cord-306921-3afgpunj	419	17	Cytoplasmic	Cytoplasmic	NNP
cord-306921-3afgpunj	419	18	redistribution	redistribution	NN
cord-306921-3afgpunj	419	19	and	and	CC
cord-306921-3afgpunj	419	20	cleavage	cleavage	NN
cord-306921-3afgpunj	419	21	of	of	IN
cord-306921-3afgpunj	419	22	AUF1	AUF1	NNP
cord-306921-3afgpunj	419	23	during	during	IN
cord-306921-3afgpunj	419	24	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	419	25	infection	infection	NN
cord-306921-3afgpunj	419	26	enhance	enhance	VBP
cord-306921-3afgpunj	419	27	the	the	DT
cord-306921-3afgpunj	419	28	stability	stability	NN
cord-306921-3afgpunj	419	29	of	of	IN
cord-306921-3afgpunj	419	30	its	-PRON-	PRP$
cord-306921-3afgpunj	419	31	viral	viral	JJ
cord-306921-3afgpunj	419	32	genome	genome	NN
cord-306921-3afgpunj	419	33	Cellular	Cellular	NNP
cord-306921-3afgpunj	419	34	mRNA	mRNA	NNP
cord-306921-3afgpunj	419	35	decay	decay	NN
cord-306921-3afgpunj	419	36	protein	protein	NN
cord-306921-3afgpunj	419	37	AUF1	AUF1	NNP
cord-306921-3afgpunj	419	38	negatively	negatively	RB
cord-306921-3afgpunj	419	39	regulates	regulate	VBZ
cord-306921-3afgpunj	419	40	Enterovirus	enterovirus	NN
cord-306921-3afgpunj	419	41	and	and	CC
cord-306921-3afgpunj	419	42	human	human	JJ
cord-306921-3afgpunj	419	43	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	419	44	infections	infection	NNS
cord-306921-3afgpunj	419	45	Picornavirus	Picornavirus	NNP
cord-306921-3afgpunj	419	46	modification	modification	NN
cord-306921-3afgpunj	419	47	of	of	IN
cord-306921-3afgpunj	419	48	a	a	DT
cord-306921-3afgpunj	419	49	host	host	NN
cord-306921-3afgpunj	419	50	mRNA	mrna	NN
cord-306921-3afgpunj	419	51	decay	decay	NN
cord-306921-3afgpunj	419	52	protein	protein	NN
cord-306921-3afgpunj	419	53	Differential	differential	JJ
cord-306921-3afgpunj	419	54	restriction	restriction	NN
cord-306921-3afgpunj	419	55	patterns	pattern	NNS
cord-306921-3afgpunj	419	56	of	of	IN
cord-306921-3afgpunj	419	57	mRNA	mrna	NN
cord-306921-3afgpunj	419	58	decay	decay	NN
cord-306921-3afgpunj	419	59	factor	factor	NN
cord-306921-3afgpunj	419	60	AUF1	AUF1	NNP
cord-306921-3afgpunj	419	61	during	during	IN
cord-306921-3afgpunj	419	62	picornavirus	picornavirus	NNP
cord-306921-3afgpunj	419	63	infections	infection	NNS
cord-306921-3afgpunj	419	64	mRNA	mRNA	NNP
cord-306921-3afgpunj	419	65	decay	decay	NN
cord-306921-3afgpunj	419	66	factor	factor	NN
cord-306921-3afgpunj	420	1	AUF1	AUF1	NNP
cord-306921-3afgpunj	420	2	binds	bind	VBZ
cord-306921-3afgpunj	420	3	the	the	DT
cord-306921-3afgpunj	420	4	internal	internal	JJ
cord-306921-3afgpunj	420	5	ribosomal	ribosomal	JJ
cord-306921-3afgpunj	420	6	entry	entry	NN
cord-306921-3afgpunj	420	7	site	site	NN
cord-306921-3afgpunj	420	8	of	of	IN
cord-306921-3afgpunj	420	9	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	420	10	71	71	CD
cord-306921-3afgpunj	420	11	and	and	CC
cord-306921-3afgpunj	420	12	inhibits	inhibit	VBZ
cord-306921-3afgpunj	420	13	virus	virus	NN
cord-306921-3afgpunj	420	14	replication	replication	NN
cord-306921-3afgpunj	421	1	The	the	DT
cord-306921-3afgpunj	421	2	role	role	NN
cord-306921-3afgpunj	421	3	of	of	IN
cord-306921-3afgpunj	421	4	misshapen	misshapen	JJ
cord-306921-3afgpunj	421	5	NCK	NCK	NNP
cord-306921-3afgpunj	421	6	-	-	HYPH
cord-306921-3afgpunj	421	7	related	relate	VBN
cord-306921-3afgpunj	421	8	kinase	kinase	NN
cord-306921-3afgpunj	421	9	(	(	-LRB-
cord-306921-3afgpunj	421	10	MINK	MINK	NNP
cord-306921-3afgpunj	421	11	)	)	-RRB-
cord-306921-3afgpunj	421	12	,	,	,
cord-306921-3afgpunj	421	13	a	a	DT
cord-306921-3afgpunj	421	14	novel	novel	JJ
cord-306921-3afgpunj	421	15	Ste20	Ste20	NNP
cord-306921-3afgpunj	421	16	family	family	NN
cord-306921-3afgpunj	421	17	kinase	kinase	NN
cord-306921-3afgpunj	421	18	,	,	,
cord-306921-3afgpunj	421	19	in	in	IN
cord-306921-3afgpunj	421	20	the	the	DT
cord-306921-3afgpunj	421	21	IRES	IRES	NNP
cord-306921-3afgpunj	421	22	-	-	HYPH
cord-306921-3afgpunj	421	23	mediated	mediate	VBN
cord-306921-3afgpunj	421	24	protein	protein	NN
cord-306921-3afgpunj	421	25	translation	translation	NN
cord-306921-3afgpunj	421	26	of	of	IN
cord-306921-3afgpunj	421	27	human	human	JJ
cord-306921-3afgpunj	421	28	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	421	29	71	71	CD
cord-306921-3afgpunj	421	30	Functional	functional	JJ
cord-306921-3afgpunj	421	31	interaction	interaction	NN
cord-306921-3afgpunj	421	32	of	of	IN
cord-306921-3afgpunj	421	33	heterogeneous	heterogeneous	JJ
cord-306921-3afgpunj	421	34	nuclear	nuclear	JJ
cord-306921-3afgpunj	421	35	ribonucleoprotein	ribonucleoprotein	NN
cord-306921-3afgpunj	421	36	C	C	NNP
cord-306921-3afgpunj	421	37	with	with	IN
cord-306921-3afgpunj	421	38	poliovirus	poliovirus	NN
cord-306921-3afgpunj	421	39	RNA	RNA	NNP
cord-306921-3afgpunj	421	40	synthesis	synthesis	NN
cord-306921-3afgpunj	421	41	initiation	initiation	NN
cord-306921-3afgpunj	421	42	complexes	complex	NNS
cord-306921-3afgpunj	421	43	Translation	Translation	NNP
cord-306921-3afgpunj	421	44	of	of	IN
cord-306921-3afgpunj	421	45	polioviral	polioviral	NNP
cord-306921-3afgpunj	421	46	mRNA	mRNA	NNP
cord-306921-3afgpunj	421	47	is	be	VBZ
cord-306921-3afgpunj	421	48	inhibited	inhibit	VBN
cord-306921-3afgpunj	421	49	by	by	IN
cord-306921-3afgpunj	421	50	cleavage	cleavage	NN
cord-306921-3afgpunj	421	51	of	of	IN
cord-306921-3afgpunj	421	52	polypyrimidine	polypyrimidine	JJ
cord-306921-3afgpunj	421	53	tract	tract	NN
cord-306921-3afgpunj	421	54	-	-	HYPH
cord-306921-3afgpunj	421	55	binding	bind	VBG
cord-306921-3afgpunj	421	56	proteins	protein	NNS
cord-306921-3afgpunj	421	57	executed	execute	VBN
cord-306921-3afgpunj	421	58	by	by	IN
cord-306921-3afgpunj	421	59	polioviral	polioviral	NNP
cord-306921-3afgpunj	421	60	3C(pro	3c(pro	CD
cord-306921-3afgpunj	421	61	)	)	-RRB-
cord-306921-3afgpunj	421	62	Cell	cell	NN
cord-306921-3afgpunj	421	63	-	-	HYPH
cord-306921-3afgpunj	421	64	type	type	NN
cord-306921-3afgpunj	421	65	-	-	HYPH
cord-306921-3afgpunj	421	66	specific	specific	JJ
cord-306921-3afgpunj	421	67	repression	repression	NN
cord-306921-3afgpunj	421	68	of	of	IN
cord-306921-3afgpunj	421	69	internal	internal	JJ
cord-306921-3afgpunj	421	70	ribosome	ribosome	NN
cord-306921-3afgpunj	421	71	entry	entry	NN
cord-306921-3afgpunj	421	72	site	site	NN
cord-306921-3afgpunj	421	73	activity	activity	NN
cord-306921-3afgpunj	421	74	by	by	IN
cord-306921-3afgpunj	421	75	double	double	RB
cord-306921-3afgpunj	421	76	-	-	HYPH
cord-306921-3afgpunj	421	77	stranded	strand	VBN
cord-306921-3afgpunj	421	78	RNA	rna	NN
cord-306921-3afgpunj	421	79	-	-	HYPH
cord-306921-3afgpunj	421	80	binding	bind	VBG
cord-306921-3afgpunj	421	81	protein	protein	NN
cord-306921-3afgpunj	421	82	76	76	CD
cord-306921-3afgpunj	422	1	The	the	DT
cord-306921-3afgpunj	422	2	double	double	RB
cord-306921-3afgpunj	422	3	-	-	HYPH
cord-306921-3afgpunj	422	4	stranded	stranded	JJ
cord-306921-3afgpunj	422	5	RNA	RNA	NNP
cord-306921-3afgpunj	422	6	binding	bind	VBG
cord-306921-3afgpunj	422	7	protein	protein	NN
cord-306921-3afgpunj	422	8	76	76	CD
cord-306921-3afgpunj	422	9	:	:	:
cord-306921-3afgpunj	423	1	NF45	NF45	NNP
cord-306921-3afgpunj	423	2	heterodimer	heterodimer	NN
cord-306921-3afgpunj	423	3	inhibits	inhibit	VBZ
cord-306921-3afgpunj	423	4	translation	translation	NN
cord-306921-3afgpunj	423	5	initiation	initiation	NN
cord-306921-3afgpunj	423	6	at	at	IN
cord-306921-3afgpunj	423	7	the	the	DT
cord-306921-3afgpunj	423	8	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	423	9	type	type	NN
cord-306921-3afgpunj	423	10	2	2	CD
cord-306921-3afgpunj	423	11	internal	internal	JJ
cord-306921-3afgpunj	423	12	ribosome	ribosome	NN
cord-306921-3afgpunj	423	13	entry	entry	NN
cord-306921-3afgpunj	423	14	site	site	NN
cord-306921-3afgpunj	423	15	Identification	identification	NN
cord-306921-3afgpunj	423	16	of	of	IN
cord-306921-3afgpunj	423	17	cellular	cellular	JJ
cord-306921-3afgpunj	423	18	proteins	protein	NNS
cord-306921-3afgpunj	423	19	enhancing	enhance	VBG
cord-306921-3afgpunj	423	20	activities	activity	NNS
cord-306921-3afgpunj	423	21	of	of	IN
cord-306921-3afgpunj	423	22	internal	internal	JJ
cord-306921-3afgpunj	423	23	ribosomal	ribosomal	JJ
cord-306921-3afgpunj	423	24	entry	entry	NN
cord-306921-3afgpunj	423	25	sites	site	NNS
cord-306921-3afgpunj	423	26	by	by	IN
cord-306921-3afgpunj	423	27	competition	competition	NN
cord-306921-3afgpunj	423	28	with	with	IN
cord-306921-3afgpunj	423	29	oligodeoxynucleotides	oligodeoxynucleotides	NNP
cord-306921-3afgpunj	423	30	Pathologic	pathologic	JJ
cord-306921-3afgpunj	423	31	studies	study	NNS
cord-306921-3afgpunj	423	32	of	of	IN
cord-306921-3afgpunj	423	33	fatal	fatal	JJ
cord-306921-3afgpunj	423	34	cases	case	NNS
cord-306921-3afgpunj	423	35	in	in	IN
cord-306921-3afgpunj	423	36	outbreak	outbreak	NN
cord-306921-3afgpunj	423	37	of	of	IN
cord-306921-3afgpunj	423	38	hand	hand	NN
cord-306921-3afgpunj	423	39	,	,	,
cord-306921-3afgpunj	423	40	foot	foot	NN
cord-306921-3afgpunj	423	41	,	,	,
cord-306921-3afgpunj	423	42	and	and	CC
cord-306921-3afgpunj	423	43	mouth	mouth	NN
cord-306921-3afgpunj	423	44	disease	disease	NN
cord-306921-3afgpunj	424	1	Apoptosis	apoptosis	NN
cord-306921-3afgpunj	424	2	,	,	,
cord-306921-3afgpunj	424	3	pyroptosis	pyroptosis	NN
cord-306921-3afgpunj	424	4	,	,	,
cord-306921-3afgpunj	424	5	and	and	CC
cord-306921-3afgpunj	424	6	necrosis	necrosis	NN
cord-306921-3afgpunj	424	7	:	:	:
cord-306921-3afgpunj	424	8	mechanistic	mechanistic	JJ
cord-306921-3afgpunj	424	9	description	description	NN
cord-306921-3afgpunj	424	10	of	of	IN
cord-306921-3afgpunj	424	11	dead	dead	JJ
cord-306921-3afgpunj	424	12	and	and	CC
cord-306921-3afgpunj	424	13	dying	die	VBG
cord-306921-3afgpunj	424	14	eukaryotic	eukaryotic	JJ
cord-306921-3afgpunj	424	15	cells	cell	NNS
cord-306921-3afgpunj	424	16	Herpes	Herpes	NNP
cord-306921-3afgpunj	424	17	simplex	simplex	NN
cord-306921-3afgpunj	424	18	virus	virus	NN
cord-306921-3afgpunj	424	19	1	1	CD
cord-306921-3afgpunj	424	20	(	(	-LRB-
cord-306921-3afgpunj	424	21	HSV-1	HSV-1	NNP
cord-306921-3afgpunj	424	22	)	)	-RRB-
cord-306921-3afgpunj	424	23	and	and	CC
cord-306921-3afgpunj	425	1	HSV-2	HSV-2	NNS
cord-306921-3afgpunj	425	2	mediate	mediate	VB
cord-306921-3afgpunj	425	3	species	species	NN
cord-306921-3afgpunj	425	4	-	-	HYPH
cord-306921-3afgpunj	425	5	specific	specific	JJ
cord-306921-3afgpunj	425	6	modulations	modulation	NNS
cord-306921-3afgpunj	425	7	of	of	IN
cord-306921-3afgpunj	425	8	programmed	programmed	JJ
cord-306921-3afgpunj	425	9	necrosis	necrosis	NN
cord-306921-3afgpunj	425	10	through	through	IN
cord-306921-3afgpunj	425	11	the	the	DT
cord-306921-3afgpunj	425	12	viral	viral	JJ
cord-306921-3afgpunj	425	13	ribonucleotide	ribonucleotide	NN
cord-306921-3afgpunj	425	14	reductase	reductase	NN
cord-306921-3afgpunj	425	15	large	large	JJ
cord-306921-3afgpunj	425	16	subunit	subunit	NN
cord-306921-3afgpunj	425	17	R1	R1	NNP
cord-306921-3afgpunj	425	18	RIP1	RIP1	NNP
cord-306921-3afgpunj	425	19	/	/	SYM
cord-306921-3afgpunj	425	20	RIP3	RIP3	NNS
cord-306921-3afgpunj	425	21	binding	bind	VBG
cord-306921-3afgpunj	425	22	to	to	IN
cord-306921-3afgpunj	425	23	HSV-1	HSV-1	NNP
cord-306921-3afgpunj	425	24	ICP6	ICP6	NNP
cord-306921-3afgpunj	426	1	initiates	initiate	VBZ
cord-306921-3afgpunj	426	2	necroptosis	necroptosis	NNP
cord-306921-3afgpunj	426	3	to	to	TO
cord-306921-3afgpunj	426	4	restrict	restrict	VB
cord-306921-3afgpunj	426	5	virus	virus	NN
cord-306921-3afgpunj	426	6	propagation	propagation	NN
cord-306921-3afgpunj	426	7	in	in	IN
cord-306921-3afgpunj	426	8	mice	mouse	NNS
cord-306921-3afgpunj	427	1	Speciesindependent	Speciesindependent	NNP
cord-306921-3afgpunj	427	2	contribution	contribution	NN
cord-306921-3afgpunj	427	3	of	of	IN
cord-306921-3afgpunj	427	4	ZBP1	ZBP1	NNP
cord-306921-3afgpunj	427	5	/	/	SYM
cord-306921-3afgpunj	427	6	DAI	DAI	NNP
cord-306921-3afgpunj	427	7	/	/	SYM
cord-306921-3afgpunj	427	8	DLM-1-triggered	dlm-1-triggere	VBN
cord-306921-3afgpunj	427	9	necroptosis	necroptosis	NNP
cord-306921-3afgpunj	427	10	in	in	IN
cord-306921-3afgpunj	427	11	host	host	NN
cord-306921-3afgpunj	427	12	defense	defense	NN
cord-306921-3afgpunj	427	13	against	against	IN
cord-306921-3afgpunj	427	14	HSV1	HSV1	NNP
cord-306921-3afgpunj	427	15	IL-1β	IL-1β	NNP
cord-306921-3afgpunj	427	16	signaling	signaling	NN
cord-306921-3afgpunj	427	17	promotes	promote	VBZ
cord-306921-3afgpunj	427	18	CNS	CNS	NNP
cord-306921-3afgpunj	427	19	-	-	HYPH
cord-306921-3afgpunj	427	20	intrinsic	intrinsic	JJ
cord-306921-3afgpunj	427	21	immune	immune	JJ
cord-306921-3afgpunj	427	22	control	control	NN
cord-306921-3afgpunj	427	23	of	of	IN
cord-306921-3afgpunj	427	24	West	West	NNP
cord-306921-3afgpunj	427	25	Nile	Nile	NNP
cord-306921-3afgpunj	427	26	virus	virus	NN
cord-306921-3afgpunj	427	27	infection	infection	NN
cord-306921-3afgpunj	427	28	Caspase-1-dependent	Caspase-1-dependent	NNP
cord-306921-3afgpunj	427	29	pore	pore	NN
cord-306921-3afgpunj	427	30	formation	formation	NN
cord-306921-3afgpunj	427	31	during	during	IN
cord-306921-3afgpunj	427	32	pyroptosis	pyroptosis	NNP
cord-306921-3afgpunj	427	33	leads	lead	VBZ
cord-306921-3afgpunj	427	34	to	to	IN
cord-306921-3afgpunj	427	35	osmotic	osmotic	JJ
cord-306921-3afgpunj	427	36	lysis	lysis	NN
cord-306921-3afgpunj	427	37	of	of	IN
cord-306921-3afgpunj	427	38	infected	infected	JJ
cord-306921-3afgpunj	427	39	host	host	NN
cord-306921-3afgpunj	427	40	macrophages	macrophage	VBZ
cord-306921-3afgpunj	427	41	Subversion	Subversion	NNP
cord-306921-3afgpunj	427	42	of	of	IN
cord-306921-3afgpunj	427	43	inflammasome	inflammasome	NN
cord-306921-3afgpunj	427	44	activation	activation	NN
cord-306921-3afgpunj	427	45	and	and	CC
cord-306921-3afgpunj	427	46	pyroptosis	pyroptosis	NN
cord-306921-3afgpunj	427	47	by	by	IN
cord-306921-3afgpunj	427	48	pathogenic	pathogenic	JJ
cord-306921-3afgpunj	427	49	bacteria	bacteria	NNS
cord-306921-3afgpunj	427	50	Pyroptosis	Pyroptosis	NNP
cord-306921-3afgpunj	427	51	induced	induce	VBN
cord-306921-3afgpunj	427	52	by	by	IN
cord-306921-3afgpunj	427	53	enterovirus	enterovirus	NN
cord-306921-3afgpunj	427	54	A71	A71	NNP
cord-306921-3afgpunj	427	55	infection	infection	NN
cord-306921-3afgpunj	427	56	in	in	IN
cord-306921-3afgpunj	427	57	cultured	cultured	JJ
cord-306921-3afgpunj	427	58	human	human	JJ
cord-306921-3afgpunj	427	59	neuroblastoma	neuroblastoma	NN
cord-306921-3afgpunj	427	60	cells	cell	NNS
cord-306921-3afgpunj	427	61	AIM2	AIM2	NNP
cord-306921-3afgpunj	427	62	Inflammasome	Inflammasome	NNP
cord-306921-3afgpunj	427	63	-	-	HYPH
cord-306921-3afgpunj	427	64	mediated	mediate	VBN
cord-306921-3afgpunj	427	65	Pyroptosis	Pyroptosis	NNP
cord-306921-3afgpunj	427	66	in	in	IN
cord-306921-3afgpunj	427	67	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	427	68	A71-infected	A71-infected	NNP
cord-306921-3afgpunj	427	69	neuronal	neuronal	JJ
cord-306921-3afgpunj	427	70	cells	cell	NNS
cord-306921-3afgpunj	427	71	restricts	restrict	VBZ
cord-306921-3afgpunj	428	1	viral	viral	JJ
cord-306921-3afgpunj	428	2	replication	replication	NN
cord-306921-3afgpunj	428	3	RSAD2	RSAD2	NNPS
cord-306921-3afgpunj	428	4	and	and	CC
cord-306921-3afgpunj	428	5	AIM2	AIM2	NNPS
cord-306921-3afgpunj	428	6	modulate	modulate	VBP
cord-306921-3afgpunj	428	7	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	428	8	A16	A16	NNP
cord-306921-3afgpunj	428	9	and	and	CC
cord-306921-3afgpunj	428	10	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	428	11	A71	A71	NNP
cord-306921-3afgpunj	428	12	replication	replication	NN
cord-306921-3afgpunj	428	13	in	in	IN
cord-306921-3afgpunj	428	14	neuronal	neuronal	JJ
cord-306921-3afgpunj	428	15	cells	cell	NNS
cord-306921-3afgpunj	428	16	in	in	IN
cord-306921-3afgpunj	428	17	different	different	JJ
cord-306921-3afgpunj	428	18	ways	way	NNS
cord-306921-3afgpunj	428	19	that	that	WDT
cord-306921-3afgpunj	428	20	may	may	MD
cord-306921-3afgpunj	428	21	be	be	VB
cord-306921-3afgpunj	428	22	associated	associate	VBN
cord-306921-3afgpunj	428	23	with	with	IN
cord-306921-3afgpunj	428	24	their	-PRON-	PRP$
cord-306921-3afgpunj	428	25	5′	5′	CD
cord-306921-3afgpunj	428	26	nontranslated	nontranslate	VBN
cord-306921-3afgpunj	428	27	regions	region	NNS
cord-306921-3afgpunj	429	1	Encephalomyocarditis	encephalomyocarditis	NN
cord-306921-3afgpunj	429	2	virus	virus	NN
cord-306921-3afgpunj	429	3	Viroporin	Viroporin	NNP
cord-306921-3afgpunj	429	4	2B	2B	NNP
cord-306921-3afgpunj	429	5	activates	activate	VBZ
cord-306921-3afgpunj	429	6	NLRP3	nlrp3	XX
cord-306921-3afgpunj	430	1	Inflammasome	Inflammasome	NNP
cord-306921-3afgpunj	430	2	Rhinovirus	Rhinovirus	NNP
cord-306921-3afgpunj	430	3	-	-	HYPH
cord-306921-3afgpunj	430	4	induced	induce	VBN
cord-306921-3afgpunj	430	5	calcium	calcium	NN
cord-306921-3afgpunj	430	6	flux	flux	NN
cord-306921-3afgpunj	430	7	triggers	trigger	VBZ
cord-306921-3afgpunj	431	1	NLRP3	NLRP3	NNP
cord-306921-3afgpunj	431	2	and	and	CC
cord-306921-3afgpunj	431	3	NLRC5	nlrc5	NN
cord-306921-3afgpunj	432	1	activation	activation	NN
cord-306921-3afgpunj	432	2	in	in	IN
cord-306921-3afgpunj	432	3	bronchial	bronchial	JJ
cord-306921-3afgpunj	432	4	cells	cell	NNS
cord-306921-3afgpunj	432	5	Immune	immune	NN
cord-306921-3afgpunj	432	6	-	-	HYPH
cord-306921-3afgpunj	432	7	complexed	complexed	JJ
cord-306921-3afgpunj	432	8	adenovirus	adenovirus	NN
cord-306921-3afgpunj	432	9	induce	induce	VBP
cord-306921-3afgpunj	432	10	AIM2-mediated	AIM2-mediated	NNP
cord-306921-3afgpunj	432	11	Pyroptosis	Pyroptosis	NNP
cord-306921-3afgpunj	432	12	in	in	IN
cord-306921-3afgpunj	432	13	human	human	JJ
cord-306921-3afgpunj	432	14	dendritic	dendritic	JJ
cord-306921-3afgpunj	432	15	cells	cell	NNS
cord-306921-3afgpunj	433	1	SV40	SV40	NNP
cord-306921-3afgpunj	434	1	large	large	JJ
cord-306921-3afgpunj	434	2	tumor	tumor	NN
cord-306921-3afgpunj	434	3	antigen	antigen	NN
cord-306921-3afgpunj	434	4	forms	form	VBZ
cord-306921-3afgpunj	434	5	a	a	DT
cord-306921-3afgpunj	434	6	specific	specific	JJ
cord-306921-3afgpunj	434	7	complex	complex	NN
cord-306921-3afgpunj	434	8	with	with	IN
cord-306921-3afgpunj	434	9	the	the	DT
cord-306921-3afgpunj	434	10	product	product	NN
cord-306921-3afgpunj	434	11	of	of	IN
cord-306921-3afgpunj	434	12	the	the	DT
cord-306921-3afgpunj	434	13	retinoblastoma	retinoblastoma	NN
cord-306921-3afgpunj	434	14	susceptibility	susceptibility	NNP
cord-306921-3afgpunj	434	15	gene	gene	NNP
cord-306921-3afgpunj	434	16	Association	Association	NNP
cord-306921-3afgpunj	434	17	of	of	IN
cord-306921-3afgpunj	434	18	human	human	JJ
cord-306921-3afgpunj	434	19	papillomavirus	papillomavirus	NN
cord-306921-3afgpunj	434	20	types	type	NNS
cord-306921-3afgpunj	435	1	16	16	CD
cord-306921-3afgpunj	435	2	and	and	CC
cord-306921-3afgpunj	435	3	18	18	CD
cord-306921-3afgpunj	435	4	E6	e6	NN
cord-306921-3afgpunj	435	5	proteins	protein	NNS
cord-306921-3afgpunj	435	6	with	with	IN
cord-306921-3afgpunj	435	7	p53	p53	NN
cord-306921-3afgpunj	435	8	Herpesvirus	Herpesvirus	NNP
cord-306921-3afgpunj	435	9	lytic	lytic	JJ
cord-306921-3afgpunj	435	10	replication	replication	NN
cord-306921-3afgpunj	435	11	and	and	CC
cord-306921-3afgpunj	435	12	the	the	DT
cord-306921-3afgpunj	435	13	cell	cell	NN
cord-306921-3afgpunj	435	14	cycle	cycle	NN
cord-306921-3afgpunj	435	15	:	:	:
cord-306921-3afgpunj	436	1	arresting	arrest	VBG
cord-306921-3afgpunj	436	2	new	new	JJ
cord-306921-3afgpunj	436	3	developments	development	NNS
cord-306921-3afgpunj	436	4	Cell	Cell	NNP
cord-306921-3afgpunj	436	5	cycle	cycle	NN
cord-306921-3afgpunj	436	6	arrest	arrest	NN
cord-306921-3afgpunj	436	7	and	and	CC
cord-306921-3afgpunj	436	8	apoptosis	apoptosis	NN
cord-306921-3afgpunj	436	9	induced	induce	VBN
cord-306921-3afgpunj	436	10	by	by	IN
cord-306921-3afgpunj	436	11	the	the	DT
cord-306921-3afgpunj	436	12	coronavirus	coronavirus	NN
cord-306921-3afgpunj	436	13	infectious	infectious	JJ
cord-306921-3afgpunj	436	14	bronchitis	bronchitis	NN
cord-306921-3afgpunj	436	15	virus	virus	NN
cord-306921-3afgpunj	436	16	in	in	IN
cord-306921-3afgpunj	436	17	the	the	DT
cord-306921-3afgpunj	436	18	absence	absence	NN
cord-306921-3afgpunj	436	19	of	of	IN
cord-306921-3afgpunj	436	20	p53	p53	NN
cord-306921-3afgpunj	436	21	Cell	cell	NN
cord-306921-3afgpunj	436	22	cycle	cycle	NN
cord-306921-3afgpunj	436	23	perturbations	perturbation	NNS
cord-306921-3afgpunj	436	24	induced	induce	VBN
cord-306921-3afgpunj	436	25	by	by	IN
cord-306921-3afgpunj	436	26	infection	infection	NN
cord-306921-3afgpunj	436	27	with	with	IN
cord-306921-3afgpunj	436	28	the	the	DT
cord-306921-3afgpunj	436	29	coronavirus	coronavirus	NN
cord-306921-3afgpunj	436	30	infectious	infectious	JJ
cord-306921-3afgpunj	436	31	bronchitis	bronchitis	NN
cord-306921-3afgpunj	436	32	virus	virus	NN
cord-306921-3afgpunj	436	33	and	and	CC
cord-306921-3afgpunj	436	34	their	-PRON-	PRP$
cord-306921-3afgpunj	436	35	effect	effect	NN
cord-306921-3afgpunj	436	36	on	on	IN
cord-306921-3afgpunj	436	37	virus	virus	NN
cord-306921-3afgpunj	436	38	replication	replication	NN
cord-306921-3afgpunj	436	39	Influenza	influenza	NN
cord-306921-3afgpunj	437	1	a	a	DT
cord-306921-3afgpunj	437	2	virus	virus	NN
cord-306921-3afgpunj	437	3	replication	replication	NN
cord-306921-3afgpunj	437	4	induces	induce	VBZ
cord-306921-3afgpunj	437	5	cell	cell	NN
cord-306921-3afgpunj	437	6	cycle	cycle	NN
cord-306921-3afgpunj	437	7	arrest	arrest	NN
cord-306921-3afgpunj	437	8	in	in	IN
cord-306921-3afgpunj	437	9	G0	G0	NNP
cord-306921-3afgpunj	437	10	/	/	SYM
cord-306921-3afgpunj	437	11	G1	G1	NNP
cord-306921-3afgpunj	437	12	phase	phase	NN
cord-306921-3afgpunj	437	13	Human	human	JJ
cord-306921-3afgpunj	437	14	immunodeficiency	immunodeficiency	NN
cord-306921-3afgpunj	437	15	virus	virus	NN
cord-306921-3afgpunj	437	16	type	type	NN
cord-306921-3afgpunj	437	17	1	1	CD
cord-306921-3afgpunj	437	18	viral	viral	JJ
cord-306921-3afgpunj	437	19	protein	protein	NN
cord-306921-3afgpunj	437	20	R	r	NN
cord-306921-3afgpunj	437	21	(	(	-LRB-
cord-306921-3afgpunj	437	22	Vpr	Vpr	NNP
cord-306921-3afgpunj	437	23	)	)	-RRB-
cord-306921-3afgpunj	437	24	arrests	arrest	NNS
cord-306921-3afgpunj	437	25	cells	cell	NNS
cord-306921-3afgpunj	437	26	in	in	IN
cord-306921-3afgpunj	437	27	the	the	DT
cord-306921-3afgpunj	437	28	G2	G2	NNP
cord-306921-3afgpunj	437	29	phase	phase	NN
cord-306921-3afgpunj	437	30	of	of	IN
cord-306921-3afgpunj	437	31	the	the	DT
cord-306921-3afgpunj	437	32	cell	cell	NN
cord-306921-3afgpunj	437	33	cycle	cycle	NN
cord-306921-3afgpunj	437	34	by	by	IN
cord-306921-3afgpunj	437	35	inhibiting	inhibit	VBG
cord-306921-3afgpunj	438	1	p34cdc2	p34cdc2	DT
cord-306921-3afgpunj	438	2	activity	activity	NN
cord-306921-3afgpunj	438	3	HIV-1	HIV-1	NNP
cord-306921-3afgpunj	438	4	Vpr	Vpr	NNP
cord-306921-3afgpunj	438	5	increases	increase	VBZ
cord-306921-3afgpunj	438	6	viral	viral	JJ
cord-306921-3afgpunj	438	7	expression	expression	NN
cord-306921-3afgpunj	438	8	by	by	IN
cord-306921-3afgpunj	438	9	manipulation	manipulation	NN
cord-306921-3afgpunj	438	10	of	of	IN
cord-306921-3afgpunj	438	11	the	the	DT
cord-306921-3afgpunj	438	12	cell	cell	NN
cord-306921-3afgpunj	438	13	cycle	cycle	NN
cord-306921-3afgpunj	438	14	:	:	:
cord-306921-3afgpunj	438	15	a	a	DT
cord-306921-3afgpunj	438	16	mechanism	mechanism	NN
cord-306921-3afgpunj	438	17	for	for	IN
cord-306921-3afgpunj	438	18	selection	selection	NN
cord-306921-3afgpunj	438	19	of	of	IN
cord-306921-3afgpunj	438	20	Vpr	Vpr	NNP
cord-306921-3afgpunj	438	21	in	in	IN
cord-306921-3afgpunj	438	22	vivo	vivo	NN
cord-306921-3afgpunj	438	23	Murine	murine	JJ
cord-306921-3afgpunj	438	24	coronavirus	coronavirus	NN
cord-306921-3afgpunj	438	25	replication	replication	NN
cord-306921-3afgpunj	438	26	induces	induce	VBZ
cord-306921-3afgpunj	438	27	cell	cell	NN
cord-306921-3afgpunj	438	28	cycle	cycle	NN
cord-306921-3afgpunj	438	29	arrest	arrest	NN
cord-306921-3afgpunj	438	30	in	in	IN
cord-306921-3afgpunj	438	31	G0	G0	NNP
cord-306921-3afgpunj	438	32	/	/	SYM
cord-306921-3afgpunj	438	33	G1	G1	NNP
cord-306921-3afgpunj	438	34	phase	phase	NN
cord-306921-3afgpunj	438	35	G0	G0	NNP
cord-306921-3afgpunj	438	36	/	/	SYM
cord-306921-3afgpunj	438	37	G1	G1	NNP
cord-306921-3afgpunj	438	38	arrest	arrest	NN
cord-306921-3afgpunj	438	39	and	and	CC
cord-306921-3afgpunj	438	40	apoptosis	apoptosis	NN
cord-306921-3afgpunj	438	41	induced	induce	VBN
cord-306921-3afgpunj	438	42	by	by	IN
cord-306921-3afgpunj	438	43	SARS	SARS	NNP
cord-306921-3afgpunj	438	44	-	-	HYPH
cord-306921-3afgpunj	438	45	CoV	CoV	NNP
cord-306921-3afgpunj	438	46	3b	3b	NNP
cord-306921-3afgpunj	438	47	protein	protein	NN
cord-306921-3afgpunj	438	48	in	in	IN
cord-306921-3afgpunj	438	49	transfected	transfecte	VBN
cord-306921-3afgpunj	438	50	cells	cell	NNS
cord-306921-3afgpunj	439	1	SARS	SARS	NNP
cord-306921-3afgpunj	439	2	coronavirus	coronavirus	NNP
cord-306921-3afgpunj	440	1	7a	7a	NN
cord-306921-3afgpunj	440	2	protein	protein	NN
cord-306921-3afgpunj	440	3	blocks	block	VBZ
cord-306921-3afgpunj	440	4	cell	cell	NN
cord-306921-3afgpunj	440	5	cycle	cycle	NN
cord-306921-3afgpunj	440	6	progression	progression	NN
cord-306921-3afgpunj	440	7	at	at	IN
cord-306921-3afgpunj	440	8	G0	G0	NNP
cord-306921-3afgpunj	440	9	/	/	SYM
cord-306921-3afgpunj	440	10	G1	G1	NNP
cord-306921-3afgpunj	440	11	phase	phase	NN
cord-306921-3afgpunj	440	12	via	via	IN
cord-306921-3afgpunj	440	13	the	the	DT
cord-306921-3afgpunj	440	14	cyclin	cyclin	NN
cord-306921-3afgpunj	440	15	D3	D3	NNP
cord-306921-3afgpunj	440	16	/	/	SYM
cord-306921-3afgpunj	440	17	pRb	prb	NN
cord-306921-3afgpunj	440	18	pathway	pathway	NN
cord-306921-3afgpunj	440	19	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	440	20	71	71	CD
cord-306921-3afgpunj	440	21	mediates	mediate	VBZ
cord-306921-3afgpunj	440	22	cell	cell	NN
cord-306921-3afgpunj	440	23	cycle	cycle	NN
cord-306921-3afgpunj	440	24	arrest	arrest	NN
cord-306921-3afgpunj	440	25	in	in	IN
cord-306921-3afgpunj	440	26	S	S	NNP
cord-306921-3afgpunj	440	27	phase	phase	NN
cord-306921-3afgpunj	440	28	through	through	IN
cord-306921-3afgpunj	440	29	non	non	JJ
cord-306921-3afgpunj	440	30	-	-	JJ
cord-306921-3afgpunj	440	31	structural	structural	JJ
cord-306921-3afgpunj	440	32	protein	protein	NN
cord-306921-3afgpunj	440	33	3D	3D	NNP
cord-306921-3afgpunj	440	34	Human	Human	NNP
cord-306921-3afgpunj	440	35	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	440	36	68	68	CD
cord-306921-3afgpunj	440	37	interferes	interfere	VBZ
cord-306921-3afgpunj	440	38	with	with	IN
cord-306921-3afgpunj	440	39	the	the	DT
cord-306921-3afgpunj	440	40	host	host	NN
cord-306921-3afgpunj	440	41	cell	cell	NN
cord-306921-3afgpunj	440	42	cycle	cycle	NN
cord-306921-3afgpunj	440	43	to	to	TO
cord-306921-3afgpunj	440	44	facilitate	facilitate	VB
cord-306921-3afgpunj	440	45	viral	viral	JJ
cord-306921-3afgpunj	440	46	production	production	NN
cord-306921-3afgpunj	440	47	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	440	48	A6	A6	NNP
cord-306921-3afgpunj	440	49	induces	induce	VBZ
cord-306921-3afgpunj	440	50	cell	cell	NN
cord-306921-3afgpunj	440	51	cycle	cycle	NN
cord-306921-3afgpunj	440	52	arrest	arrest	NN
cord-306921-3afgpunj	440	53	in	in	IN
cord-306921-3afgpunj	440	54	G0	G0	NNP
cord-306921-3afgpunj	440	55	/	/	SYM
cord-306921-3afgpunj	440	56	G1	G1	NNP
cord-306921-3afgpunj	440	57	phase	phase	NN
cord-306921-3afgpunj	440	58	for	for	IN
cord-306921-3afgpunj	440	59	viral	viral	JJ
cord-306921-3afgpunj	440	60	production	production	NN
cord-306921-3afgpunj	440	61	Remodeling	remodel	VBG
cord-306921-3afgpunj	440	62	the	the	DT
cord-306921-3afgpunj	440	63	endoplasmic	endoplasmic	NN
cord-306921-3afgpunj	440	64	reticulum	reticulum	NN
cord-306921-3afgpunj	440	65	by	by	IN
cord-306921-3afgpunj	440	66	poliovirus	poliovirus	NN
cord-306921-3afgpunj	440	67	infection	infection	NN
cord-306921-3afgpunj	440	68	and	and	CC
cord-306921-3afgpunj	440	69	by	by	IN
cord-306921-3afgpunj	440	70	individual	individual	JJ
cord-306921-3afgpunj	440	71	viral	viral	JJ
cord-306921-3afgpunj	440	72	proteins	protein	NNS
cord-306921-3afgpunj	440	73	:	:	:
cord-306921-3afgpunj	440	74	an	an	DT
cord-306921-3afgpunj	440	75	autophagy	autophagy	NN
cord-306921-3afgpunj	440	76	-	-	HYPH
cord-306921-3afgpunj	440	77	like	like	JJ
cord-306921-3afgpunj	440	78	origin	origin	NN
cord-306921-3afgpunj	440	79	for	for	IN
cord-306921-3afgpunj	440	80	virus	virus	NN
cord-306921-3afgpunj	440	81	-	-	HYPH
cord-306921-3afgpunj	440	82	induced	induce	VBN
cord-306921-3afgpunj	440	83	vesicles	vesicle	NNS
cord-306921-3afgpunj	441	1	Pancreatic	pancreatic	JJ
cord-306921-3afgpunj	441	2	acinar	acinar	JJ
cord-306921-3afgpunj	441	3	cell	cell	NN
cord-306921-3afgpunj	441	4	-	-	HYPH
cord-306921-3afgpunj	441	5	specific	specific	JJ
cord-306921-3afgpunj	441	6	autophagy	autophagy	NN
cord-306921-3afgpunj	441	7	disruption	disruption	NN
cord-306921-3afgpunj	441	8	reduces	reduce	VBZ
cord-306921-3afgpunj	441	9	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	441	10	replication	replication	NN
cord-306921-3afgpunj	441	11	and	and	CC
cord-306921-3afgpunj	441	12	pathogenesis	pathogenesis	NN
cord-306921-3afgpunj	441	13	in	in	IN
cord-306921-3afgpunj	441	14	vivo	vivo	NN
cord-306921-3afgpunj	441	15	Subversion	subversion	NN
cord-306921-3afgpunj	441	16	of	of	IN
cord-306921-3afgpunj	441	17	cellular	cellular	JJ
cord-306921-3afgpunj	441	18	Autophagosomal	Autophagosomal	NNP
cord-306921-3afgpunj	441	19	machinery	machinery	NN
cord-306921-3afgpunj	441	20	by	by	IN
cord-306921-3afgpunj	441	21	RNA	RNA	NNP
cord-306921-3afgpunj	441	22	viruses	virus	NNS
cord-306921-3afgpunj	441	23	Membrane	membrane	NN
cord-306921-3afgpunj	441	24	rearrangement	rearrangement	NN
cord-306921-3afgpunj	441	25	and	and	CC
cord-306921-3afgpunj	441	26	vesicle	vesicle	NN
cord-306921-3afgpunj	441	27	induction	induction	NN
cord-306921-3afgpunj	441	28	by	by	IN
cord-306921-3afgpunj	441	29	recombinant	recombinant	JJ
cord-306921-3afgpunj	441	30	poliovirus	poliovirus	NN
cord-306921-3afgpunj	441	31	2C	2c	NN
cord-306921-3afgpunj	441	32	and	and	CC
cord-306921-3afgpunj	441	33	2BC	2BC	NNP
cord-306921-3afgpunj	441	34	in	in	IN
cord-306921-3afgpunj	441	35	human	human	JJ
cord-306921-3afgpunj	441	36	cells	cell	NNS
cord-306921-3afgpunj	442	1	Cellular	cellular	JJ
cord-306921-3afgpunj	442	2	origin	origin	NN
cord-306921-3afgpunj	442	3	and	and	CC
cord-306921-3afgpunj	442	4	ultrastructure	ultrastructure	NN
cord-306921-3afgpunj	442	5	of	of	IN
cord-306921-3afgpunj	442	6	membranes	membrane	NNS
cord-306921-3afgpunj	442	7	induced	induce	VBN
cord-306921-3afgpunj	442	8	during	during	IN
cord-306921-3afgpunj	442	9	poliovirus	poliovirus	NN
cord-306921-3afgpunj	442	10	infection	infection	NN
cord-306921-3afgpunj	443	1	Autophagosome	Autophagosome	NNP
cord-306921-3afgpunj	443	2	supports	support	VBZ
cord-306921-3afgpunj	443	3	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	443	4	B3	b3	NN
cord-306921-3afgpunj	443	5	replication	replication	NN
cord-306921-3afgpunj	443	6	in	in	IN
cord-306921-3afgpunj	443	7	host	host	NN
cord-306921-3afgpunj	443	8	cells	cell	NNS
cord-306921-3afgpunj	444	1	BPIFB6	BPIFB6	NNP
cord-306921-3afgpunj	444	2	regulates	regulate	VBZ
cord-306921-3afgpunj	444	3	secretory	secretory	JJ
cord-306921-3afgpunj	444	4	pathway	pathway	NN
cord-306921-3afgpunj	444	5	trafficking	trafficking	NN
cord-306921-3afgpunj	444	6	and	and	CC
cord-306921-3afgpunj	444	7	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	444	8	replication	replication	NN
cord-306921-3afgpunj	444	9	BPIFB3	bpifb3	WDT
cord-306921-3afgpunj	444	10	regulates	regulate	VBZ
cord-306921-3afgpunj	444	11	autophagy	autophagy	NN
cord-306921-3afgpunj	444	12	and	and	CC
cord-306921-3afgpunj	444	13	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	444	14	B	B	NNP
cord-306921-3afgpunj	444	15	replication	replication	NN
cord-306921-3afgpunj	444	16	through	through	IN
cord-306921-3afgpunj	444	17	a	a	DT
cord-306921-3afgpunj	444	18	noncanonical	noncanonical	JJ
cord-306921-3afgpunj	444	19	pathway	pathway	NN
cord-306921-3afgpunj	444	20	independent	independent	JJ
cord-306921-3afgpunj	444	21	of	of	IN
cord-306921-3afgpunj	444	22	the	the	DT
cord-306921-3afgpunj	444	23	Core	Core	NNP
cord-306921-3afgpunj	444	24	initiation	initiation	NN
cord-306921-3afgpunj	444	25	machinery	machinery	NN
cord-306921-3afgpunj	445	1	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	445	2	B3	b3	NN
cord-306921-3afgpunj	445	3	induces	induce	VBZ
cord-306921-3afgpunj	445	4	the	the	DT
cord-306921-3afgpunj	445	5	formation	formation	NN
cord-306921-3afgpunj	445	6	of	of	IN
cord-306921-3afgpunj	445	7	autophagosomes	autophagosomes	NNP
cord-306921-3afgpunj	445	8	in	in	IN
cord-306921-3afgpunj	445	9	cardiac	cardiac	JJ
cord-306921-3afgpunj	445	10	fibroblasts	fibroblast	NNS
cord-306921-3afgpunj	445	11	both	both	DT
cord-306921-3afgpunj	445	12	in	in	IN
cord-306921-3afgpunj	445	13	vitro	vitro	FW
cord-306921-3afgpunj	445	14	and	and	CC
cord-306921-3afgpunj	445	15	in	in	IN
cord-306921-3afgpunj	445	16	vivo	vivo	NNP
cord-306921-3afgpunj	445	17	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	445	18	B	B	NNP
cord-306921-3afgpunj	445	19	exits	exit	VBZ
cord-306921-3afgpunj	445	20	the	the	DT
cord-306921-3afgpunj	445	21	host	host	NN
cord-306921-3afgpunj	445	22	cell	cell	NN
cord-306921-3afgpunj	445	23	in	in	IN
cord-306921-3afgpunj	445	24	shed	shed	NN
cord-306921-3afgpunj	445	25	microvesicles	microvesicle	NNS
cord-306921-3afgpunj	445	26	displaying	display	VBG
cord-306921-3afgpunj	445	27	Autophagosomal	Autophagosomal	NNP
cord-306921-3afgpunj	445	28	markers	marker	NNS
cord-306921-3afgpunj	446	1	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	446	2	B	B	NNP
cord-306921-3afgpunj	446	3	escapes	escape	VBZ
cord-306921-3afgpunj	446	4	the	the	DT
cord-306921-3afgpunj	446	5	infected	infected	JJ
cord-306921-3afgpunj	446	6	cell	cell	NN
cord-306921-3afgpunj	446	7	in	in	IN
cord-306921-3afgpunj	446	8	ejected	eject	VBN
cord-306921-3afgpunj	446	9	Mitophagosomes	Mitophagosomes	NNP
cord-306921-3afgpunj	446	10	Hepatitis	Hepatitis	NNP
cord-306921-3afgpunj	446	11	C	C	NNP
cord-306921-3afgpunj	446	12	virus	virus	NN
cord-306921-3afgpunj	446	13	triggers	trigger	VBZ
cord-306921-3afgpunj	446	14	mitochondrial	mitochondrial	JJ
cord-306921-3afgpunj	446	15	fission	fission	NN
cord-306921-3afgpunj	446	16	and	and	CC
cord-306921-3afgpunj	446	17	attenuates	attenuate	VBZ
cord-306921-3afgpunj	446	18	apoptosis	apoptosis	NN
cord-306921-3afgpunj	446	19	to	to	TO
cord-306921-3afgpunj	446	20	promote	promote	VB
cord-306921-3afgpunj	446	21	viral	viral	JJ
cord-306921-3afgpunj	446	22	persistence	persistence	NN
cord-306921-3afgpunj	446	23	Enterovirus	enterovirus	NN
cord-306921-3afgpunj	446	24	71-induced	71-induced	CD
cord-306921-3afgpunj	446	25	autophagy	autophagy	NN
cord-306921-3afgpunj	446	26	increases	increase	VBZ
cord-306921-3afgpunj	446	27	viral	viral	JJ
cord-306921-3afgpunj	446	28	replication	replication	NN
cord-306921-3afgpunj	446	29	and	and	CC
cord-306921-3afgpunj	446	30	pathogenesis	pathogenesis	NN
cord-306921-3afgpunj	446	31	in	in	IN
cord-306921-3afgpunj	446	32	a	a	DT
cord-306921-3afgpunj	446	33	suckling	suckle	VBG
cord-306921-3afgpunj	446	34	mouse	mouse	NN
cord-306921-3afgpunj	446	35	model	model	NN
cord-306921-3afgpunj	446	36	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	446	37	71-induced	71-induced	CD
cord-306921-3afgpunj	446	38	autophagy	autophagy	NN
cord-306921-3afgpunj	446	39	detected	detect	VBN
cord-306921-3afgpunj	446	40	in	in	IN
cord-306921-3afgpunj	446	41	vitro	vitro	FW
cord-306921-3afgpunj	446	42	and	and	CC
cord-306921-3afgpunj	447	1	in	in	IN
cord-306921-3afgpunj	447	2	vivo	vivo	NNP
cord-306921-3afgpunj	447	3	promotes	promote	VBZ
cord-306921-3afgpunj	447	4	viral	viral	JJ
cord-306921-3afgpunj	447	5	replication	replication	NN
cord-306921-3afgpunj	447	6	2BC	2bc	NN
cord-306921-3afgpunj	447	7	nonstructural	nonstructural	JJ
cord-306921-3afgpunj	447	8	protein	protein	NN
cord-306921-3afgpunj	447	9	of	of	IN
cord-306921-3afgpunj	447	10	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	447	11	A71	A71	NNP
cord-306921-3afgpunj	447	12	interacts	interact	VBZ
cord-306921-3afgpunj	447	13	with	with	IN
cord-306921-3afgpunj	447	14	SNARE	snare	NN
cord-306921-3afgpunj	447	15	proteins	protein	NNS
cord-306921-3afgpunj	447	16	to	to	TO
cord-306921-3afgpunj	447	17	trigger	trigger	VB
cord-306921-3afgpunj	447	18	autolysosome	autolysosome	NNP
cord-306921-3afgpunj	447	19	formation	formation	NN
cord-306921-3afgpunj	448	1	Enteroviruses	Enteroviruses	NNP
cord-306921-3afgpunj	448	2	remodel	remodel	VBP
cord-306921-3afgpunj	449	1	Autophagic	Autophagic	NNP
cord-306921-3afgpunj	449	2	trafficking	traffic	VBG
cord-306921-3afgpunj	449	3	through	through	IN
cord-306921-3afgpunj	449	4	regulation	regulation	NN
cord-306921-3afgpunj	449	5	of	of	IN
cord-306921-3afgpunj	449	6	host	host	NN
cord-306921-3afgpunj	449	7	SNARE	snare	VB
cord-306921-3afgpunj	449	8	proteins	protein	NNS
cord-306921-3afgpunj	449	9	to	to	TO
cord-306921-3afgpunj	449	10	promote	promote	VB
cord-306921-3afgpunj	449	11	virus	virus	NN
cord-306921-3afgpunj	449	12	replication	replication	NN
cord-306921-3afgpunj	449	13	and	and	CC
cord-306921-3afgpunj	449	14	cell	cell	NN
cord-306921-3afgpunj	449	15	exit	exit	NN
cord-306921-3afgpunj	450	1	The	the	DT
cord-306921-3afgpunj	450	2	autophagic	autophagic	NN
cord-306921-3afgpunj	450	3	machinery	machinery	NN
cord-306921-3afgpunj	450	4	in	in	IN
cord-306921-3afgpunj	450	5	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	450	6	infection	infection	NN
cord-306921-3afgpunj	450	7	Enterovirus	enterovirus	NN
cord-306921-3afgpunj	450	8	transmission	transmission	NN
cord-306921-3afgpunj	450	9	by	by	IN
cord-306921-3afgpunj	450	10	secretory	secretory	JJ
cord-306921-3afgpunj	450	11	autophagy	autophagy	NN
cord-306921-3afgpunj	450	12	SNAP	snap	VB
cord-306921-3afgpunj	450	13	!	!	.
cord-306921-3afgpunj	451	1	How	how	WRB
cord-306921-3afgpunj	451	2	enteroviruses	enteroviruses	NNP
cord-306921-3afgpunj	451	3	redirect	redirect	VBP
cord-306921-3afgpunj	451	4	autophagic	autophagic	NN
cord-306921-3afgpunj	451	5	traffic	traffic	NN
cord-306921-3afgpunj	451	6	away	away	RB
cord-306921-3afgpunj	451	7	from	from	IN
cord-306921-3afgpunj	451	8	degradation	degradation	NN
cord-306921-3afgpunj	452	1	Enteroviral	enteroviral	JJ
cord-306921-3afgpunj	452	2	infection	infection	NN
cord-306921-3afgpunj	452	3	inhibits	inhibit	VBZ
cord-306921-3afgpunj	452	4	Autophagic	Autophagic	NNP
cord-306921-3afgpunj	452	5	flux	flux	NN
cord-306921-3afgpunj	452	6	via	via	IN
cord-306921-3afgpunj	452	7	disruption	disruption	NN
cord-306921-3afgpunj	452	8	of	of	IN
cord-306921-3afgpunj	452	9	the	the	DT
cord-306921-3afgpunj	452	10	SNARE	snare	NN
cord-306921-3afgpunj	452	11	complex	complex	NN
cord-306921-3afgpunj	452	12	to	to	TO
cord-306921-3afgpunj	452	13	enhance	enhance	VB
cord-306921-3afgpunj	452	14	viral	viral	JJ
cord-306921-3afgpunj	452	15	replication	replication	NN
cord-306921-3afgpunj	453	1	The	the	DT
cord-306921-3afgpunj	453	2	exoribonuclease	exoribonuclease	NN
cord-306921-3afgpunj	454	1	Xrn1	Xrn1	NNP
cord-306921-3afgpunj	454	2	is	be	VBZ
cord-306921-3afgpunj	454	3	a	a	DT
cord-306921-3afgpunj	454	4	post	post	JJ
cord-306921-3afgpunj	454	5	-	-	JJ
cord-306921-3afgpunj	454	6	transcriptional	transcriptional	JJ
cord-306921-3afgpunj	454	7	negative	negative	JJ
cord-306921-3afgpunj	454	8	regulator	regulator	NN
cord-306921-3afgpunj	454	9	of	of	IN
cord-306921-3afgpunj	454	10	autophagy	autophagy	NN
cord-306921-3afgpunj	455	1	Poliovirus	Poliovirus	NNP
cord-306921-3afgpunj	455	2	induces	induce	VBZ
cord-306921-3afgpunj	455	3	autophagic	autophagic	NNP
cord-306921-3afgpunj	455	4	signaling	signal	VBG
cord-306921-3afgpunj	455	5	independent	independent	JJ
cord-306921-3afgpunj	455	6	of	of	IN
cord-306921-3afgpunj	455	7	the	the	DT
cord-306921-3afgpunj	455	8	ULK1	ULK1	NNP
cord-306921-3afgpunj	455	9	complex	complex	NN
cord-306921-3afgpunj	455	10	Cleavage	cleavage	NN
cord-306921-3afgpunj	455	11	of	of	IN
cord-306921-3afgpunj	455	12	sequestosome	sequestosome	NNP
cord-306921-3afgpunj	455	13	1	1	CD
cord-306921-3afgpunj	455	14	/	/	SYM
cord-306921-3afgpunj	455	15	p62	p62	NN
cord-306921-3afgpunj	455	16	by	by	IN
cord-306921-3afgpunj	455	17	an	an	DT
cord-306921-3afgpunj	455	18	enteroviral	enteroviral	JJ
cord-306921-3afgpunj	455	19	protease	protease	NN
cord-306921-3afgpunj	455	20	results	result	NNS
cord-306921-3afgpunj	455	21	in	in	IN
cord-306921-3afgpunj	455	22	disrupted	disrupt	VBN
cord-306921-3afgpunj	455	23	selective	selective	JJ
cord-306921-3afgpunj	455	24	autophagy	autophagy	NN
cord-306921-3afgpunj	455	25	and	and	CC
cord-306921-3afgpunj	455	26	impaired	impair	VBN
cord-306921-3afgpunj	455	27	NFKB	NFKB	NNP
cord-306921-3afgpunj	455	28	signaling	signal	VBG
cord-306921-3afgpunj	455	29	Selective	selective	JJ
cord-306921-3afgpunj	455	30	autophagy	autophagy	NN
cord-306921-3afgpunj	455	31	regulates	regulate	VBZ
cord-306921-3afgpunj	455	32	various	various	JJ
cord-306921-3afgpunj	455	33	cellular	cellular	JJ
cord-306921-3afgpunj	455	34	functions	function	NNS
cord-306921-3afgpunj	455	35	Selective	selective	JJ
cord-306921-3afgpunj	455	36	degradation	degradation	NN
cord-306921-3afgpunj	455	37	of	of	IN
cord-306921-3afgpunj	455	38	p62	p62	NN
cord-306921-3afgpunj	455	39	by	by	IN
cord-306921-3afgpunj	455	40	autophagy	autophagy	NN
cord-306921-3afgpunj	455	41	Selective	selective	JJ
cord-306921-3afgpunj	455	42	autophagy	autophagy	NN
cord-306921-3afgpunj	455	43	mediated	mediate	VBN
cord-306921-3afgpunj	455	44	by	by	IN
cord-306921-3afgpunj	455	45	autophagic	autophagic	NNP
cord-306921-3afgpunj	455	46	adapter	adapter	NN
cord-306921-3afgpunj	455	47	proteins	protein	NNS
cord-306921-3afgpunj	456	1	CALCOCO2	CALCOCO2	''
cord-306921-3afgpunj	457	1	/NDP52	/NDP52	NFP
cord-306921-3afgpunj	457	2	and	and	CC
cord-306921-3afgpunj	457	3	SQSTM1	SQSTM1	NNP
cord-306921-3afgpunj	457	4	/	/	SYM
cord-306921-3afgpunj	457	5	p62	p62	NN
cord-306921-3afgpunj	458	1	differentially	differentially	RB
cord-306921-3afgpunj	458	2	regulate	regulate	VB
cord-306921-3afgpunj	458	3	coxsackievirus	coxsackievirus	NNP
cord-306921-3afgpunj	458	4	B3	b3	NN
cord-306921-3afgpunj	458	5	propagation	propagation	NN
cord-306921-3afgpunj	458	6	.	.	.
cord-306921-3afgpunj	459	1	Cell	cell	NN
cord-306921-3afgpunj	459	2	death	death	NN
cord-306921-3afgpunj	459	3	differ	differ	VBP
cord-306921-3afgpunj	459	4	Viral	viral	JJ
cord-306921-3afgpunj	459	5	strategies	strategy	NNS
cord-306921-3afgpunj	459	6	for	for	IN
cord-306921-3afgpunj	459	7	triggering	trigger	VBG
cord-306921-3afgpunj	459	8	and	and	CC
cord-306921-3afgpunj	459	9	manipulating	manipulate	VBG
cord-306921-3afgpunj	459	10	mitophagy	mitophagy	NNS
cord-306921-3afgpunj	460	1	Ribavirin	ribavirin	RB
cord-306921-3afgpunj	460	2	reduces	reduce	VBZ
cord-306921-3afgpunj	460	3	mortality	mortality	NN
cord-306921-3afgpunj	460	4	in	in	IN
cord-306921-3afgpunj	460	5	Enterovirus	enterovirus	NN
cord-306921-3afgpunj	460	6	71-infected	71-infected	CD
cord-306921-3afgpunj	460	7	mice	mouse	NNS
cord-306921-3afgpunj	460	8	by	by	IN
cord-306921-3afgpunj	460	9	decreasing	decrease	VBG
cord-306921-3afgpunj	460	10	viral	viral	JJ
cord-306921-3afgpunj	460	11	replication	replication	NN
cord-306921-3afgpunj	460	12	Inhibition	inhibition	NN
cord-306921-3afgpunj	460	13	of	of	IN
cord-306921-3afgpunj	460	14	enterovirus	enterovirus	NN
cord-306921-3afgpunj	460	15	71	71	CD
cord-306921-3afgpunj	460	16	replication	replication	NN
cord-306921-3afgpunj	460	17	and	and	CC
cord-306921-3afgpunj	460	18	viral	viral	JJ
cord-306921-3afgpunj	460	19	3C	3c	NN
cord-306921-3afgpunj	460	20	protease	protease	NN
cord-306921-3afgpunj	460	21	by	by	IN
cord-306921-3afgpunj	460	22	quercetin	quercetin	NNP
cord-306921-3afgpunj	460	23	Design	design	NN
cord-306921-3afgpunj	460	24	,	,	,
cord-306921-3afgpunj	460	25	synthesis	synthesis	NN
cord-306921-3afgpunj	460	26	,	,	,
cord-306921-3afgpunj	460	27	and	and	CC
cord-306921-3afgpunj	460	28	structure	structure	NN
cord-306921-3afgpunj	460	29	-	-	HYPH
cord-306921-3afgpunj	460	30	activity	activity	NN
cord-306921-3afgpunj	460	31	relationships	relationship	NNS
cord-306921-3afgpunj	460	32	of	of	IN
cord-306921-3afgpunj	460	33	pyrazolo[3,4-d]pyrimidines	pyrazolo[3,4-d]pyrimidines	NNPS
cord-306921-3afgpunj	460	34	:	:	:
cord-306921-3afgpunj	460	35	a	a	DT
cord-306921-3afgpunj	460	36	novel	novel	JJ
cord-306921-3afgpunj	460	37	class	class	NN
cord-306921-3afgpunj	460	38	of	of	IN
cord-306921-3afgpunj	460	39	potent	potent	JJ
cord-306921-3afgpunj	460	40	enterovirus	enterovirus	NN
cord-306921-3afgpunj	460	41	inhibitors	inhibitor	NNS
cord-306921-3afgpunj	461	1	Andrographolide	Andrographolide	NNP
cord-306921-3afgpunj	461	2	prevents	prevent	VBZ
cord-306921-3afgpunj	461	3	EV	EV	NNP
cord-306921-3afgpunj	461	4	-	-	HYPH
cord-306921-3afgpunj	461	5	D68	D68	NNP
cord-306921-3afgpunj	461	6	replication	replication	NN
cord-306921-3afgpunj	461	7	by	by	IN
cord-306921-3afgpunj	461	8	inhibiting	inhibit	VBG
cord-306921-3afgpunj	461	9	the	the	DT
cord-306921-3afgpunj	461	10	acidification	acidification	NN
cord-306921-3afgpunj	461	11	of	of	IN
cord-306921-3afgpunj	461	12	viruscontaining	viruscontaine	VBG
cord-306921-3afgpunj	461	13	endocytic	endocytic	JJ
cord-306921-3afgpunj	461	14	vesicles	vesicle	NNS
cord-306921-3afgpunj	462	1	In	in	IN
cord-306921-3afgpunj	462	2	vitro	vitro	FW
cord-306921-3afgpunj	462	3	assessment	assessment	NN
cord-306921-3afgpunj	462	4	of	of	IN
cord-306921-3afgpunj	462	5	combinations	combination	NNS
cord-306921-3afgpunj	462	6	of	of	IN
cord-306921-3afgpunj	462	7	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	462	8	inhibitors	inhibitor	NNS
cord-306921-3afgpunj	462	9	against	against	IN
cord-306921-3afgpunj	462	10	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	462	11	71	71	CD
cord-306921-3afgpunj	462	12	Screening	screening	NN
cord-306921-3afgpunj	462	13	of	of	IN
cord-306921-3afgpunj	462	14	a	a	DT
cord-306921-3afgpunj	462	15	library	library	NN
cord-306921-3afgpunj	462	16	of	of	IN
cord-306921-3afgpunj	462	17	FDA	FDA	NNP
cord-306921-3afgpunj	462	18	-	-	HYPH
cord-306921-3afgpunj	462	19	approved	approve	VBN
cord-306921-3afgpunj	462	20	drugs	drug	NNS
cord-306921-3afgpunj	462	21	identifies	identify	VBZ
cord-306921-3afgpunj	462	22	several	several	JJ
cord-306921-3afgpunj	462	23	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	462	24	replication	replication	NN
cord-306921-3afgpunj	462	25	inhibitors	inhibitor	NNS
cord-306921-3afgpunj	462	26	that	that	WDT
cord-306921-3afgpunj	462	27	target	target	VBP
cord-306921-3afgpunj	462	28	viral	viral	JJ
cord-306921-3afgpunj	462	29	protein	protein	NN
cord-306921-3afgpunj	462	30	2C	2C	NNP
cord-306921-3afgpunj	462	31	Flavonoids	Flavonoids	NNP
cord-306921-3afgpunj	462	32	:	:	:
cord-306921-3afgpunj	462	33	promising	promise	VBG
cord-306921-3afgpunj	462	34	natural	natural	JJ
cord-306921-3afgpunj	462	35	compounds	compound	NNS
cord-306921-3afgpunj	462	36	against	against	IN
cord-306921-3afgpunj	462	37	viral	viral	JJ
cord-306921-3afgpunj	462	38	infections	infection	NNS
cord-306921-3afgpunj	462	39	Chemistry	chemistry	NN
cord-306921-3afgpunj	462	40	and	and	CC
cord-306921-3afgpunj	462	41	biological	biological	JJ
cord-306921-3afgpunj	462	42	activities	activity	NNS
cord-306921-3afgpunj	462	43	of	of	IN
cord-306921-3afgpunj	462	44	flavonoids	flavonoid	NNS
cord-306921-3afgpunj	462	45	:	:	:
cord-306921-3afgpunj	462	46	an	an	DT
cord-306921-3afgpunj	462	47	overview	overview	NN
cord-306921-3afgpunj	462	48	The	the	DT
cord-306921-3afgpunj	462	49	flavonoid	flavonoid	NN
cord-306921-3afgpunj	462	50	Isoquercitrin	Isoquercitrin	NNP
cord-306921-3afgpunj	462	51	precludes	preclude	VBZ
cord-306921-3afgpunj	462	52	initiation	initiation	NN
cord-306921-3afgpunj	462	53	of	of	IN
cord-306921-3afgpunj	462	54	Zika	Zika	NNP
cord-306921-3afgpunj	462	55	virus	virus	NN
cord-306921-3afgpunj	462	56	infection	infection	NN
cord-306921-3afgpunj	462	57	in	in	IN
cord-306921-3afgpunj	462	58	human	human	JJ
cord-306921-3afgpunj	462	59	cells	cell	NNS
cord-306921-3afgpunj	462	60	Antiviral	antiviral	JJ
cord-306921-3afgpunj	462	61	activity	activity	NN
cord-306921-3afgpunj	462	62	of	of	IN
cord-306921-3afgpunj	462	63	selected	select	VBN
cord-306921-3afgpunj	462	64	flavonoids	flavonoid	NNS
cord-306921-3afgpunj	462	65	against	against	IN
cord-306921-3afgpunj	462	66	chikungunya	chikungunya	NN
cord-306921-3afgpunj	462	67	virus	virus	NN
cord-306921-3afgpunj	463	1	The	the	DT
cord-306921-3afgpunj	463	2	flavonoid	flavonoid	NN
cord-306921-3afgpunj	463	3	apigenin	apigenin	NN
cord-306921-3afgpunj	463	4	inhibits	inhibit	VBZ
cord-306921-3afgpunj	463	5	hepatitis	hepatitis	NNP
cord-306921-3afgpunj	463	6	C	C	NNP
cord-306921-3afgpunj	463	7	virus	virus	NN
cord-306921-3afgpunj	463	8	replication	replication	NN
cord-306921-3afgpunj	463	9	by	by	IN
cord-306921-3afgpunj	463	10	decreasing	decrease	VBG
cord-306921-3afgpunj	463	11	mature	mature	JJ
cord-306921-3afgpunj	463	12	microRNA122	microrna122	ADD
cord-306921-3afgpunj	463	13	levels	level	NNS
cord-306921-3afgpunj	464	1	Apigenin	Apigenin	NNP
cord-306921-3afgpunj	464	2	inhibits	inhibit	VBZ
cord-306921-3afgpunj	464	3	African	african	JJ
cord-306921-3afgpunj	464	4	swine	swine	NN
cord-306921-3afgpunj	464	5	fever	fever	NN
cord-306921-3afgpunj	464	6	virus	virus	NN
cord-306921-3afgpunj	464	7	infection	infection	NN
cord-306921-3afgpunj	465	1	in	in	IN
cord-306921-3afgpunj	465	2	vitro	vitro	FW
cord-306921-3afgpunj	466	1	Apigenin	Apigenin	NNP
cord-306921-3afgpunj	466	2	inhibits	inhibit	VBZ
cord-306921-3afgpunj	466	3	Enterovirus-71	enterovirus-71	NN
cord-306921-3afgpunj	466	4	infection	infection	NN
cord-306921-3afgpunj	466	5	by	by	IN
cord-306921-3afgpunj	466	6	disrupting	disrupt	VBG
cord-306921-3afgpunj	466	7	viral	viral	JJ
cord-306921-3afgpunj	466	8	RNA	RNA	NNP
cord-306921-3afgpunj	466	9	association	association	NN
cord-306921-3afgpunj	466	10	with	with	IN
cord-306921-3afgpunj	466	11	transacting	transact	VBG
cord-306921-3afgpunj	466	12	factors	factor	NNS
cord-306921-3afgpunj	467	1	Apigenin	Apigenin	NNP
cord-306921-3afgpunj	467	2	inhibits	inhibit	VBZ
cord-306921-3afgpunj	467	3	enterovirus	enterovirus	NN
cord-306921-3afgpunj	467	4	71	71	CD
cord-306921-3afgpunj	467	5	replication	replication	NN
cord-306921-3afgpunj	467	6	through	through	IN
cord-306921-3afgpunj	467	7	suppressing	suppress	VBG
cord-306921-3afgpunj	467	8	viral	viral	JJ
cord-306921-3afgpunj	467	9	IRES	ires	JJ
cord-306921-3afgpunj	467	10	activity	activity	NN
cord-306921-3afgpunj	467	11	and	and	CC
cord-306921-3afgpunj	467	12	modulating	modulate	VBG
cord-306921-3afgpunj	467	13	cellular	cellular	JJ
cord-306921-3afgpunj	467	14	JNK	JNK	NNP
cord-306921-3afgpunj	467	15	pathway	pathway	NN
cord-306921-3afgpunj	467	16	Apigenin	Apigenin	NNP
cord-306921-3afgpunj	467	17	restricts	restrict	VBZ
cord-306921-3afgpunj	467	18	FMDV	FMDV	NNP
cord-306921-3afgpunj	467	19	infection	infection	NN
cord-306921-3afgpunj	467	20	and	and	CC
cord-306921-3afgpunj	467	21	inhibits	inhibit	VBZ
cord-306921-3afgpunj	467	22	viral	viral	JJ
cord-306921-3afgpunj	467	23	IRES	IRES	NNP
cord-306921-3afgpunj	467	24	driven	drive	VBN
cord-306921-3afgpunj	467	25	translational	translational	JJ
cord-306921-3afgpunj	467	26	activity	activity	NN
cord-306921-3afgpunj	467	27	A	a	DT
cord-306921-3afgpunj	467	28	flavonoid	flavonoid	NN
cord-306921-3afgpunj	467	29	compound	compound	NN
cord-306921-3afgpunj	467	30	library	library	NN
cord-306921-3afgpunj	467	31	screen	screen	NN
cord-306921-3afgpunj	467	32	revealed	reveal	VBD
cord-306921-3afgpunj	467	33	potent	potent	JJ
cord-306921-3afgpunj	467	34	antiviral	antiviral	JJ
cord-306921-3afgpunj	467	35	activity	activity	NN
cord-306921-3afgpunj	467	36	of	of	IN
cord-306921-3afgpunj	467	37	plant	plant	NN
cord-306921-3afgpunj	467	38	-	-	HYPH
cord-306921-3afgpunj	467	39	derived	derive	VBN
cord-306921-3afgpunj	467	40	flavonoids	flavonoid	NNS
cord-306921-3afgpunj	467	41	on	on	IN
cord-306921-3afgpunj	467	42	human	human	JJ
cord-306921-3afgpunj	467	43	enterovirus	enterovirus	NN
cord-306921-3afgpunj	467	44	A71	A71	NNP
cord-306921-3afgpunj	467	45	replication	replication	NN
cord-306921-3afgpunj	467	46	Novel	Novel	NNP
cord-306921-3afgpunj	467	47	antiviral	antiviral	JJ
cord-306921-3afgpunj	467	48	agent	agent	NN
cord-306921-3afgpunj	467	49	DTriP-22	DTriP-22	NNP
cord-306921-3afgpunj	467	50	targets	target	VBZ
cord-306921-3afgpunj	467	51	RNA	RNA	NNP
cord-306921-3afgpunj	467	52	-	-	HYPH
cord-306921-3afgpunj	467	53	dependent	dependent	JJ
cord-306921-3afgpunj	467	54	RNA	RNA	NNP
cord-306921-3afgpunj	467	55	polymerase	polymerase	NN
cord-306921-3afgpunj	467	56	of	of	IN
cord-306921-3afgpunj	467	57	enterovirus	enterovirus	NN
cord-306921-3afgpunj	467	58	71	71	CD
cord-306921-3afgpunj	467	59	Enterovirus	Enterovirus	NNP
cord-306921-3afgpunj	467	60	71	71	CD
cord-306921-3afgpunj	467	61	and	and	CC
cord-306921-3afgpunj	467	62	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	467	63	A16	A16	NNP
cord-306921-3afgpunj	467	64	3C	3c	NN
cord-306921-3afgpunj	467	65	proteases	protease	NNS
cord-306921-3afgpunj	467	66	:	:	:
cord-306921-3afgpunj	467	67	binding	bind	VBG
cord-306921-3afgpunj	467	68	to	to	IN
cord-306921-3afgpunj	467	69	Rupintrivir	Rupintrivir	NNP
cord-306921-3afgpunj	467	70	and	and	CC
cord-306921-3afgpunj	467	71	their	-PRON-	PRP$
cord-306921-3afgpunj	467	72	substrates	substrate	NNS
cord-306921-3afgpunj	467	73	and	and	CC
cord-306921-3afgpunj	467	74	anti	anti	JJ
cord-306921-3afgpunj	467	75	-	-	JJ
cord-306921-3afgpunj	467	76	hand	hand	JJ
cord-306921-3afgpunj	467	77	,	,	,
cord-306921-3afgpunj	467	78	foot	foot	NN
cord-306921-3afgpunj	467	79	,	,	,
cord-306921-3afgpunj	467	80	and	and	CC
cord-306921-3afgpunj	467	81	mouth	mouth	NN
cord-306921-3afgpunj	467	82	disease	disease	NNP
cord-306921-3afgpunj	467	83	virus	virus	NN
cord-306921-3afgpunj	467	84	drug	drug	NN
cord-306921-3afgpunj	467	85	design	design	NN
cord-306921-3afgpunj	468	1	In	in	IN
cord-306921-3afgpunj	468	2	vitro	vitro	FW
cord-306921-3afgpunj	468	3	antiviral	antiviral	JJ
cord-306921-3afgpunj	468	4	activity	activity	NN
cord-306921-3afgpunj	468	5	of	of	IN
cord-306921-3afgpunj	468	6	AG7088	ag7088	NN
cord-306921-3afgpunj	468	7	,	,	,
cord-306921-3afgpunj	468	8	a	a	DT
cord-306921-3afgpunj	468	9	potent	potent	JJ
cord-306921-3afgpunj	468	10	inhibitor	inhibitor	NN
cord-306921-3afgpunj	468	11	of	of	IN
cord-306921-3afgpunj	468	12	human	human	JJ
cord-306921-3afgpunj	468	13	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	468	14	3C	3C	NNP
cord-306921-3afgpunj	468	15	protease	protease	NN
cord-306921-3afgpunj	468	16	Multiple	multiple	JJ
cord-306921-3afgpunj	468	17	classes	class	NNS
cord-306921-3afgpunj	468	18	of	of	IN
cord-306921-3afgpunj	468	19	antiviral	antiviral	JJ
cord-306921-3afgpunj	468	20	agents	agent	NNS
cord-306921-3afgpunj	468	21	exhibit	exhibit	VBP
cord-306921-3afgpunj	468	22	in	in	IN
cord-306921-3afgpunj	468	23	vitro	vitro	FW
cord-306921-3afgpunj	468	24	activity	activity	NN
cord-306921-3afgpunj	468	25	against	against	IN
cord-306921-3afgpunj	468	26	human	human	JJ
cord-306921-3afgpunj	468	27	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	468	28	type	type	NN
cord-306921-3afgpunj	468	29	C	C	NNP
cord-306921-3afgpunj	468	30	Fluoxetine	Fluoxetine	NNP
cord-306921-3afgpunj	468	31	is	be	VBZ
cord-306921-3afgpunj	468	32	a	a	DT
cord-306921-3afgpunj	468	33	potent	potent	JJ
cord-306921-3afgpunj	468	34	inhibitor	inhibitor	NN
cord-306921-3afgpunj	468	35	of	of	IN
cord-306921-3afgpunj	468	36	Coxsackievirus	Coxsackievirus	NNP
cord-306921-3afgpunj	468	37	replication	replication	NN
cord-306921-3afgpunj	468	38	Formoterol	Formoterol	NNP
cord-306921-3afgpunj	468	39	and	and	CC
cord-306921-3afgpunj	468	40	budesonide	budesonide	NNP
cord-306921-3afgpunj	468	41	inhibit	inhibit	VBP
cord-306921-3afgpunj	468	42	rhinovirus	rhinovirus	NN
cord-306921-3afgpunj	468	43	infection	infection	NN
cord-306921-3afgpunj	468	44	and	and	CC
cord-306921-3afgpunj	468	45	cytokine	cytokine	NN
cord-306921-3afgpunj	468	46	production	production	NN
cord-306921-3afgpunj	468	47	in	in	IN
cord-306921-3afgpunj	468	48	primary	primary	JJ
cord-306921-3afgpunj	468	49	cultures	culture	NNS
cord-306921-3afgpunj	468	50	of	of	IN
cord-306921-3afgpunj	468	51	human	human	JJ
cord-306921-3afgpunj	468	52	tracheal	tracheal	NN
cord-306921-3afgpunj	468	53	epithelial	epithelial	JJ
cord-306921-3afgpunj	468	54	cells	cell	NNS
cord-306921-3afgpunj	469	1	Publisher	publisher	NN
cord-306921-3afgpunj	469	2	's	's	POS
cord-306921-3afgpunj	469	3	Note	Note	NNP
cord-306921-3afgpunj	469	4	Springer	Springer	NNP
cord-306921-3afgpunj	469	5	Nature	Nature	NNP
cord-306921-3afgpunj	469	6	remains	remain	VBZ
cord-306921-3afgpunj	469	7	neutral	neutral	JJ
cord-306921-3afgpunj	469	8	with	with	IN
cord-306921-3afgpunj	469	9	regard	regard	NN
cord-306921-3afgpunj	469	10	to	to	IN
cord-306921-3afgpunj	469	11	jurisdictional	jurisdictional	JJ
cord-306921-3afgpunj	469	12	claims	claim	NNS
cord-306921-3afgpunj	469	13	in	in	IN
cord-306921-3afgpunj	469	14	published	publish	VBN
cord-306921-3afgpunj	469	15	maps	map	NNS
cord-306921-3afgpunj	469	16	and	and	CC
cord-306921-3afgpunj	469	17	institutional	institutional	JJ
cord-306921-3afgpunj	469	18	affiliations	affiliation	NNS
cord-306921-3afgpunj	470	1	The	the	DT
cord-306921-3afgpunj	470	2	authors	author	NNS
cord-306921-3afgpunj	470	3	declare	declare	VBP
cord-306921-3afgpunj	470	4	that	that	IN
cord-306921-3afgpunj	470	5	they	-PRON-	PRP
cord-306921-3afgpunj	470	6	have	have	VBP
cord-306921-3afgpunj	470	7	no	no	DT
cord-306921-3afgpunj	470	8	competing	compete	VBG
cord-306921-3afgpunj	470	9	interests	interest	NNS
cord-306921-3afgpunj	470	10	.	.	.
cord-306921-3afgpunj	471	1	Received	receive	VBN
cord-306921-3afgpunj	471	2	:	:	:
cord-306921-3afgpunj	471	3	20	20	CD
cord-306921-3afgpunj	471	4	April	April	NNP
cord-306921-3afgpunj	471	5	2019	2019	CD
cord-306921-3afgpunj	472	1	Accepted	accept	VBN
cord-306921-3afgpunj	472	2	:	:	:
cord-306921-3afgpunj	472	3	11	11	CD
cord-306921-3afgpunj	472	4	June	June	NNP
cord-306921-3afgpunj	472	5	2019	2019	CD