id	sid	tid	token	lemma	pos
cord-265900-7lj4bfli	1	1	key	key	JJ
cord-265900-7lj4bfli	1	2	:	:	:
cord-265900-7lj4bfli	1	3	cord-265900	cord-265900	NNP
cord-265900-7lj4bfli	1	4	-	-	HYPH
cord-265900-7lj4bfli	1	5	7lj4bfli	7lj4bfli	JJ
cord-265900-7lj4bfli	1	6	authors	author	NNS
cord-265900-7lj4bfli	1	7	:	:	:
cord-265900-7lj4bfli	1	8	Luo	Luo	NNP
cord-265900-7lj4bfli	1	9	,	,	,
cord-265900-7lj4bfli	1	10	Honglin	Honglin	NNP
cord-265900-7lj4bfli	1	11	title	title	NN
cord-265900-7lj4bfli	1	12	:	:	:
cord-265900-7lj4bfli	1	13	Interplay	interplay	NN
cord-265900-7lj4bfli	1	14	between	between	IN
cord-265900-7lj4bfli	1	15	the	the	DT
cord-265900-7lj4bfli	1	16	virus	virus	NN
cord-265900-7lj4bfli	1	17	and	and	CC
cord-265900-7lj4bfli	1	18	the	the	DT
cord-265900-7lj4bfli	1	19	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	1	20	–	–	:
cord-265900-7lj4bfli	1	21	proteasome	proteasome	NN
cord-265900-7lj4bfli	1	22	system	system	NN
cord-265900-7lj4bfli	1	23	:	:	:
cord-265900-7lj4bfli	1	24	molecular	molecular	JJ
cord-265900-7lj4bfli	1	25	mechanism	mechanism	NN
cord-265900-7lj4bfli	1	26	of	of	IN
cord-265900-7lj4bfli	1	27	viral	viral	JJ
cord-265900-7lj4bfli	1	28	pathogenesis	pathogenesis	NN
cord-265900-7lj4bfli	1	29	date	date	NN
cord-265900-7lj4bfli	1	30	:	:	:
cord-265900-7lj4bfli	1	31	2015	2015	CD
cord-265900-7lj4bfli	1	32	-	-	HYPH
cord-265900-7lj4bfli	1	33	09	09	CD
cord-265900-7lj4bfli	1	34	-	-	SYM
cord-265900-7lj4bfli	1	35	29	29	CD
cord-265900-7lj4bfli	1	36	journal	journal	NN
cord-265900-7lj4bfli	1	37	:	:	:
cord-265900-7lj4bfli	2	1	Curr	Curr	NNP
cord-265900-7lj4bfli	2	2	Opin	Opin	NNP
cord-265900-7lj4bfli	3	1	Virol	Virol	NNP
cord-265900-7lj4bfli	3	2	DOI	doi	NN
cord-265900-7lj4bfli	3	3	:	:	:
cord-265900-7lj4bfli	4	1	10.1016	10.1016	CD
cord-265900-7lj4bfli	4	2	/	/	SYM
cord-265900-7lj4bfli	4	3	j.coviro.2015.09.005	j.coviro.2015.09.005	NNP
cord-265900-7lj4bfli	4	4	sha	sha	NN
cord-265900-7lj4bfli	4	5	:	:	:
cord-265900-7lj4bfli	4	6	5f6a0e160d0a1e1204419cc8047a2206a571b8cb	5f6a0e160d0a1e1204419cc8047a2206a571b8cb	NFP
cord-265900-7lj4bfli	4	7	doc_id	doc_id	NNP
cord-265900-7lj4bfli	4	8	:	:	:
cord-265900-7lj4bfli	4	9	265900	265900	CD
cord-265900-7lj4bfli	4	10	cord_uid	cord_uid	NNS
cord-265900-7lj4bfli	4	11	:	:	:
cord-265900-7lj4bfli	5	1	7lj4bfli	7lj4bfli	NNP
cord-265900-7lj4bfli	6	1	The	the	DT
cord-265900-7lj4bfli	6	2	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	6	3	–	–	:
cord-265900-7lj4bfli	6	4	proteasome	proteasome	NN
cord-265900-7lj4bfli	6	5	system	system	NN
cord-265900-7lj4bfli	6	6	(	(	-LRB-
cord-265900-7lj4bfli	6	7	UPS	UPS	NNP
cord-265900-7lj4bfli	6	8	)	)	-RRB-
cord-265900-7lj4bfli	6	9	plays	play	VBZ
cord-265900-7lj4bfli	6	10	a	a	DT
cord-265900-7lj4bfli	6	11	central	central	JJ
cord-265900-7lj4bfli	6	12	role	role	NN
cord-265900-7lj4bfli	6	13	in	in	IN
cord-265900-7lj4bfli	6	14	a	a	DT
cord-265900-7lj4bfli	6	15	wide	wide	JJ
cord-265900-7lj4bfli	6	16	range	range	NN
cord-265900-7lj4bfli	6	17	of	of	IN
cord-265900-7lj4bfli	6	18	fundamental	fundamental	JJ
cord-265900-7lj4bfli	6	19	cellular	cellular	JJ
cord-265900-7lj4bfli	6	20	functions	function	NNS
cord-265900-7lj4bfli	6	21	by	by	IN
cord-265900-7lj4bfli	6	22	ensuring	ensure	VBG
cord-265900-7lj4bfli	6	23	protein	protein	NN
cord-265900-7lj4bfli	6	24	quality	quality	NN
cord-265900-7lj4bfli	6	25	control	control	NN
cord-265900-7lj4bfli	6	26	and	and	CC
cord-265900-7lj4bfli	6	27	through	through	IN
cord-265900-7lj4bfli	6	28	maintaining	maintain	VBG
cord-265900-7lj4bfli	6	29	a	a	DT
cord-265900-7lj4bfli	6	30	critical	critical	JJ
cord-265900-7lj4bfli	6	31	level	level	NN
cord-265900-7lj4bfli	6	32	of	of	IN
cord-265900-7lj4bfli	6	33	important	important	JJ
cord-265900-7lj4bfli	6	34	regulatory	regulatory	JJ
cord-265900-7lj4bfli	6	35	proteins	protein	NNS
cord-265900-7lj4bfli	6	36	.	.	.
cord-265900-7lj4bfli	7	1	Viruses	virus	NNS
cord-265900-7lj4bfli	7	2	subvert	subvert	VBP
cord-265900-7lj4bfli	7	3	or	or	CC
cord-265900-7lj4bfli	7	4	manipulate	manipulate	VBP
cord-265900-7lj4bfli	7	5	this	this	DT
cord-265900-7lj4bfli	7	6	cellular	cellular	JJ
cord-265900-7lj4bfli	7	7	machinery	machinery	NN
cord-265900-7lj4bfli	7	8	to	to	TO
cord-265900-7lj4bfli	7	9	favor	favor	VB
cord-265900-7lj4bfli	7	10	viral	viral	JJ
cord-265900-7lj4bfli	7	11	propagation	propagation	NN
cord-265900-7lj4bfli	7	12	and	and	CC
cord-265900-7lj4bfli	7	13	to	to	TO
cord-265900-7lj4bfli	7	14	evade	evade	VB
cord-265900-7lj4bfli	7	15	host	host	NN
cord-265900-7lj4bfli	7	16	immune	immune	JJ
cord-265900-7lj4bfli	7	17	response	response	NN
cord-265900-7lj4bfli	7	18	.	.	.
cord-265900-7lj4bfli	8	1	The	the	DT
cord-265900-7lj4bfli	8	2	UPS	UPS	NNP
cord-265900-7lj4bfli	8	3	serves	serve	VBZ
cord-265900-7lj4bfli	8	4	as	as	IN
cord-265900-7lj4bfli	8	5	a	a	DT
cord-265900-7lj4bfli	8	6	double	double	RB
cord-265900-7lj4bfli	8	7	-	-	HYPH
cord-265900-7lj4bfli	8	8	edged	edged	JJ
cord-265900-7lj4bfli	8	9	sword	sword	NN
cord-265900-7lj4bfli	8	10	in	in	IN
cord-265900-7lj4bfli	8	11	viral	viral	JJ
cord-265900-7lj4bfli	8	12	pathogenesis	pathogenesis	NN
cord-265900-7lj4bfli	8	13	:	:	:
cord-265900-7lj4bfli	8	14	on	on	IN
cord-265900-7lj4bfli	8	15	the	the	DT
cord-265900-7lj4bfli	8	16	one	one	CD
cord-265900-7lj4bfli	8	17	hand	hand	NN
cord-265900-7lj4bfli	8	18	,	,	,
cord-265900-7lj4bfli	8	19	the	the	DT
cord-265900-7lj4bfli	8	20	UPS	UPS	NNP
cord-265900-7lj4bfli	8	21	is	be	VBZ
cord-265900-7lj4bfli	8	22	utilized	utilize	VBN
cord-265900-7lj4bfli	8	23	by	by	IN
cord-265900-7lj4bfli	8	24	many	many	JJ
cord-265900-7lj4bfli	8	25	viruses	virus	NNS
cord-265900-7lj4bfli	8	26	to	to	TO
cord-265900-7lj4bfli	8	27	maintain	maintain	VB
cord-265900-7lj4bfli	8	28	proper	proper	JJ
cord-265900-7lj4bfli	8	29	function	function	NN
cord-265900-7lj4bfli	8	30	and	and	CC
cord-265900-7lj4bfli	8	31	level	level	NN
cord-265900-7lj4bfli	8	32	of	of	IN
cord-265900-7lj4bfli	8	33	viral	viral	JJ
cord-265900-7lj4bfli	8	34	proteins	protein	NNS
cord-265900-7lj4bfli	8	35	;	;	:
cord-265900-7lj4bfli	8	36	while	while	IN
cord-265900-7lj4bfli	8	37	on	on	IN
cord-265900-7lj4bfli	8	38	the	the	DT
cord-265900-7lj4bfli	8	39	other	other	JJ
cord-265900-7lj4bfli	8	40	hand	hand	NN
cord-265900-7lj4bfli	8	41	,	,	,
cord-265900-7lj4bfli	8	42	the	the	DT
cord-265900-7lj4bfli	8	43	UPS	UPS	NNP
cord-265900-7lj4bfli	8	44	constitutes	constitute	VBZ
cord-265900-7lj4bfli	8	45	a	a	DT
cord-265900-7lj4bfli	8	46	host	host	NN
cord-265900-7lj4bfli	8	47	defense	defense	NN
cord-265900-7lj4bfli	8	48	mechanism	mechanism	NN
cord-265900-7lj4bfli	8	49	to	to	TO
cord-265900-7lj4bfli	8	50	eliminate	eliminate	VB
cord-265900-7lj4bfli	8	51	viral	viral	JJ
cord-265900-7lj4bfli	8	52	components	component	NNS
cord-265900-7lj4bfli	8	53	.	.	.
cord-265900-7lj4bfli	9	1	To	to	TO
cord-265900-7lj4bfli	9	2	combat	combat	VB
cord-265900-7lj4bfli	9	3	this	this	DT
cord-265900-7lj4bfli	9	4	host	host	NN
cord-265900-7lj4bfli	9	5	anti	anti	JJ
cord-265900-7lj4bfli	9	6	-	-	JJ
cord-265900-7lj4bfli	9	7	viral	viral	JJ
cord-265900-7lj4bfli	9	8	machinery	machinery	NN
cord-265900-7lj4bfli	9	9	,	,	,
cord-265900-7lj4bfli	9	10	viruses	virus	NNS
cord-265900-7lj4bfli	9	11	have	have	VBP
cord-265900-7lj4bfli	9	12	evolved	evolve	VBN
cord-265900-7lj4bfli	9	13	to	to	TO
cord-265900-7lj4bfli	9	14	employ	employ	VB
cord-265900-7lj4bfli	9	15	the	the	DT
cord-265900-7lj4bfli	9	16	UPS	up	NNS
cord-265900-7lj4bfli	9	17	to	to	TO
cord-265900-7lj4bfli	9	18	degrade	degrade	VB
cord-265900-7lj4bfli	9	19	or	or	CC
cord-265900-7lj4bfli	9	20	inactivate	inactivate	VB
cord-265900-7lj4bfli	9	21	cellular	cellular	JJ
cord-265900-7lj4bfli	9	22	proteins	protein	NNS
cord-265900-7lj4bfli	9	23	that	that	WDT
cord-265900-7lj4bfli	9	24	limit	limit	VBP
cord-265900-7lj4bfli	9	25	viral	viral	JJ
cord-265900-7lj4bfli	9	26	growth	growth	NN
cord-265900-7lj4bfli	9	27	.	.	.
cord-265900-7lj4bfli	10	1	This	this	DT
cord-265900-7lj4bfli	10	2	review	review	NN
cord-265900-7lj4bfli	10	3	will	will	MD
cord-265900-7lj4bfli	10	4	highlight	highlight	VB
cord-265900-7lj4bfli	10	5	our	-PRON-	PRP$
cord-265900-7lj4bfli	10	6	current	current	JJ
cord-265900-7lj4bfli	10	7	knowledge	knowledge	NN
cord-265900-7lj4bfli	10	8	pertaining	pertain	VBG
cord-265900-7lj4bfli	10	9	to	to	IN
cord-265900-7lj4bfli	10	10	the	the	DT
cord-265900-7lj4bfli	10	11	different	different	JJ
cord-265900-7lj4bfli	10	12	roles	role	NNS
cord-265900-7lj4bfli	10	13	for	for	IN
cord-265900-7lj4bfli	10	14	the	the	DT
cord-265900-7lj4bfli	10	15	UPS	up	NNS
cord-265900-7lj4bfli	10	16	in	in	IN
cord-265900-7lj4bfli	10	17	viral	viral	JJ
cord-265900-7lj4bfli	10	18	pathogenesis	pathogenesis	NN
cord-265900-7lj4bfli	10	19	.	.	.
cord-265900-7lj4bfli	11	1	Interplay	interplay	NN
cord-265900-7lj4bfli	11	2	between	between	IN
cord-265900-7lj4bfli	11	3	the	the	DT
cord-265900-7lj4bfli	11	4	virus	virus	NN
cord-265900-7lj4bfli	11	5	and	and	CC
cord-265900-7lj4bfli	11	6	the	the	DT
cord-265900-7lj4bfli	11	7	ubiquitinproteasome	ubiquitinproteasome	NN
cord-265900-7lj4bfli	11	8	system	system	NN
cord-265900-7lj4bfli	11	9	:	:	:
cord-265900-7lj4bfli	11	10	molecular	molecular	JJ
cord-265900-7lj4bfli	11	11	mechanism	mechanism	NN
cord-265900-7lj4bfli	11	12	of	of	IN
cord-265900-7lj4bfli	11	13	viral	viral	JJ
cord-265900-7lj4bfli	11	14	pathogenesis	pathogenesis	NN
cord-265900-7lj4bfli	12	1	Honglin	Honglin	NNP
cord-265900-7lj4bfli	12	2	Luo	Luo	NNP
cord-265900-7lj4bfli	12	3	1,2	1,2	CD
cord-265900-7lj4bfli	13	1	The	the	DT
cord-265900-7lj4bfli	13	2	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	13	3	-	-	HYPH
cord-265900-7lj4bfli	13	4	proteasome	proteasome	VBN
cord-265900-7lj4bfli	13	5	system	system	NN
cord-265900-7lj4bfli	13	6	(	(	-LRB-
cord-265900-7lj4bfli	13	7	UPS	UPS	NNP
cord-265900-7lj4bfli	13	8	)	)	-RRB-
cord-265900-7lj4bfli	13	9	plays	play	VBZ
cord-265900-7lj4bfli	13	10	a	a	DT
cord-265900-7lj4bfli	13	11	central	central	JJ
cord-265900-7lj4bfli	13	12	role	role	NN
cord-265900-7lj4bfli	13	13	in	in	IN
cord-265900-7lj4bfli	13	14	a	a	DT
cord-265900-7lj4bfli	13	15	wide	wide	JJ
cord-265900-7lj4bfli	13	16	range	range	NN
cord-265900-7lj4bfli	13	17	of	of	IN
cord-265900-7lj4bfli	13	18	fundamental	fundamental	JJ
cord-265900-7lj4bfli	13	19	cellular	cellular	JJ
cord-265900-7lj4bfli	13	20	functions	function	NNS
cord-265900-7lj4bfli	13	21	by	by	IN
cord-265900-7lj4bfli	13	22	ensuring	ensure	VBG
cord-265900-7lj4bfli	13	23	protein	protein	NN
cord-265900-7lj4bfli	13	24	quality	quality	NN
cord-265900-7lj4bfli	13	25	control	control	NN
cord-265900-7lj4bfli	13	26	and	and	CC
cord-265900-7lj4bfli	13	27	through	through	IN
cord-265900-7lj4bfli	13	28	maintaining	maintain	VBG
cord-265900-7lj4bfli	13	29	a	a	DT
cord-265900-7lj4bfli	13	30	critical	critical	JJ
cord-265900-7lj4bfli	13	31	level	level	NN
cord-265900-7lj4bfli	13	32	of	of	IN
cord-265900-7lj4bfli	13	33	important	important	JJ
cord-265900-7lj4bfli	13	34	regulatory	regulatory	JJ
cord-265900-7lj4bfli	13	35	proteins	protein	NNS
cord-265900-7lj4bfli	13	36	.	.	.
cord-265900-7lj4bfli	14	1	Viruses	virus	NNS
cord-265900-7lj4bfli	14	2	subvert	subvert	VBP
cord-265900-7lj4bfli	14	3	or	or	CC
cord-265900-7lj4bfli	14	4	manipulate	manipulate	VBP
cord-265900-7lj4bfli	14	5	this	this	DT
cord-265900-7lj4bfli	14	6	cellular	cellular	JJ
cord-265900-7lj4bfli	14	7	machinery	machinery	NN
cord-265900-7lj4bfli	14	8	to	to	TO
cord-265900-7lj4bfli	14	9	favor	favor	VB
cord-265900-7lj4bfli	14	10	viral	viral	JJ
cord-265900-7lj4bfli	14	11	propagation	propagation	NN
cord-265900-7lj4bfli	14	12	and	and	CC
cord-265900-7lj4bfli	14	13	to	to	TO
cord-265900-7lj4bfli	14	14	evade	evade	VB
cord-265900-7lj4bfli	14	15	host	host	NN
cord-265900-7lj4bfli	14	16	immune	immune	JJ
cord-265900-7lj4bfli	14	17	response	response	NN
cord-265900-7lj4bfli	14	18	.	.	.
cord-265900-7lj4bfli	15	1	The	the	DT
cord-265900-7lj4bfli	15	2	UPS	UPS	NNP
cord-265900-7lj4bfli	15	3	serves	serve	VBZ
cord-265900-7lj4bfli	15	4	as	as	IN
cord-265900-7lj4bfli	15	5	a	a	DT
cord-265900-7lj4bfli	15	6	double	double	RB
cord-265900-7lj4bfli	15	7	-	-	HYPH
cord-265900-7lj4bfli	15	8	edged	edged	JJ
cord-265900-7lj4bfli	15	9	sword	sword	NN
cord-265900-7lj4bfli	15	10	in	in	IN
cord-265900-7lj4bfli	15	11	viral	viral	JJ
cord-265900-7lj4bfli	15	12	pathogenesis	pathogenesis	NN
cord-265900-7lj4bfli	15	13	:	:	:
cord-265900-7lj4bfli	15	14	on	on	IN
cord-265900-7lj4bfli	15	15	the	the	DT
cord-265900-7lj4bfli	15	16	one	one	CD
cord-265900-7lj4bfli	15	17	hand	hand	NN
cord-265900-7lj4bfli	15	18	,	,	,
cord-265900-7lj4bfli	15	19	the	the	DT
cord-265900-7lj4bfli	15	20	UPS	UPS	NNP
cord-265900-7lj4bfli	15	21	is	be	VBZ
cord-265900-7lj4bfli	15	22	utilized	utilize	VBN
cord-265900-7lj4bfli	15	23	by	by	IN
cord-265900-7lj4bfli	15	24	many	many	JJ
cord-265900-7lj4bfli	15	25	viruses	virus	NNS
cord-265900-7lj4bfli	15	26	to	to	TO
cord-265900-7lj4bfli	15	27	maintain	maintain	VB
cord-265900-7lj4bfli	15	28	proper	proper	JJ
cord-265900-7lj4bfli	15	29	function	function	NN
cord-265900-7lj4bfli	15	30	and	and	CC
cord-265900-7lj4bfli	15	31	level	level	NN
cord-265900-7lj4bfli	15	32	of	of	IN
cord-265900-7lj4bfli	15	33	viral	viral	JJ
cord-265900-7lj4bfli	15	34	proteins	protein	NNS
cord-265900-7lj4bfli	15	35	;	;	:
cord-265900-7lj4bfli	15	36	while	while	IN
cord-265900-7lj4bfli	15	37	on	on	IN
cord-265900-7lj4bfli	15	38	the	the	DT
cord-265900-7lj4bfli	15	39	other	other	JJ
cord-265900-7lj4bfli	15	40	hand	hand	NN
cord-265900-7lj4bfli	15	41	,	,	,
cord-265900-7lj4bfli	15	42	the	the	DT
cord-265900-7lj4bfli	15	43	UPS	UPS	NNP
cord-265900-7lj4bfli	15	44	constitutes	constitute	VBZ
cord-265900-7lj4bfli	15	45	a	a	DT
cord-265900-7lj4bfli	15	46	host	host	NN
cord-265900-7lj4bfli	15	47	defense	defense	NN
cord-265900-7lj4bfli	15	48	mechanism	mechanism	NN
cord-265900-7lj4bfli	15	49	to	to	TO
cord-265900-7lj4bfli	15	50	eliminate	eliminate	VB
cord-265900-7lj4bfli	15	51	viral	viral	JJ
cord-265900-7lj4bfli	15	52	components	component	NNS
cord-265900-7lj4bfli	15	53	.	.	.
cord-265900-7lj4bfli	16	1	To	to	TO
cord-265900-7lj4bfli	16	2	combat	combat	VB
cord-265900-7lj4bfli	16	3	this	this	DT
cord-265900-7lj4bfli	16	4	host	host	NN
cord-265900-7lj4bfli	16	5	anti	anti	JJ
cord-265900-7lj4bfli	16	6	-	-	JJ
cord-265900-7lj4bfli	16	7	viral	viral	JJ
cord-265900-7lj4bfli	16	8	machinery	machinery	NN
cord-265900-7lj4bfli	16	9	,	,	,
cord-265900-7lj4bfli	16	10	viruses	virus	NNS
cord-265900-7lj4bfli	16	11	have	have	VBP
cord-265900-7lj4bfli	16	12	evolved	evolve	VBN
cord-265900-7lj4bfli	16	13	to	to	TO
cord-265900-7lj4bfli	16	14	employ	employ	VB
cord-265900-7lj4bfli	16	15	the	the	DT
cord-265900-7lj4bfli	16	16	UPS	up	NNS
cord-265900-7lj4bfli	16	17	to	to	TO
cord-265900-7lj4bfli	16	18	degrade	degrade	VB
cord-265900-7lj4bfli	16	19	or	or	CC
cord-265900-7lj4bfli	16	20	inactivate	inactivate	VB
cord-265900-7lj4bfli	16	21	cellular	cellular	JJ
cord-265900-7lj4bfli	16	22	proteins	protein	NNS
cord-265900-7lj4bfli	16	23	that	that	WDT
cord-265900-7lj4bfli	16	24	limit	limit	VBP
cord-265900-7lj4bfli	16	25	viral	viral	JJ
cord-265900-7lj4bfli	16	26	growth	growth	NN
cord-265900-7lj4bfli	16	27	.	.	.
cord-265900-7lj4bfli	17	1	This	this	DT
cord-265900-7lj4bfli	17	2	review	review	NN
cord-265900-7lj4bfli	17	3	will	will	MD
cord-265900-7lj4bfli	17	4	highlight	highlight	VB
cord-265900-7lj4bfli	17	5	our	-PRON-	PRP$
cord-265900-7lj4bfli	17	6	current	current	JJ
cord-265900-7lj4bfli	17	7	knowledge	knowledge	NN
cord-265900-7lj4bfli	17	8	pertaining	pertain	VBG
cord-265900-7lj4bfli	17	9	to	to	IN
cord-265900-7lj4bfli	17	10	the	the	DT
cord-265900-7lj4bfli	17	11	different	different	JJ
cord-265900-7lj4bfli	17	12	roles	role	NNS
cord-265900-7lj4bfli	17	13	for	for	IN
cord-265900-7lj4bfli	17	14	the	the	DT
cord-265900-7lj4bfli	17	15	UPS	up	NNS
cord-265900-7lj4bfli	17	16	in	in	IN
cord-265900-7lj4bfli	17	17	viral	viral	JJ
cord-265900-7lj4bfli	17	18	pathogenesis	pathogenesis	NN
cord-265900-7lj4bfli	17	19	.	.	.
cord-265900-7lj4bfli	18	1	Viruses	virus	NNS
cord-265900-7lj4bfli	18	2	have	have	VBP
cord-265900-7lj4bfli	18	3	evolved	evolve	VBN
cord-265900-7lj4bfli	18	4	to	to	TO
cord-265900-7lj4bfli	18	5	exploit	exploit	VB
cord-265900-7lj4bfli	18	6	the	the	DT
cord-265900-7lj4bfli	18	7	host	host	NN
cord-265900-7lj4bfli	18	8	cellular	cellular	JJ
cord-265900-7lj4bfli	18	9	machinery	machinery	NN
cord-265900-7lj4bfli	18	10	to	to	TO
cord-265900-7lj4bfli	18	11	establish	establish	VB
cord-265900-7lj4bfli	18	12	productive	productive	JJ
cord-265900-7lj4bfli	18	13	infection	infection	NN
cord-265900-7lj4bfli	18	14	.	.	.
cord-265900-7lj4bfli	19	1	In	in	IN
cord-265900-7lj4bfli	19	2	eukaryotic	eukaryotic	JJ
cord-265900-7lj4bfli	19	3	cells	cell	NNS
cord-265900-7lj4bfli	19	4	,	,	,
cord-265900-7lj4bfli	19	5	the	the	DT
cord-265900-7lj4bfli	19	6	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	19	7	-	-	HYPH
cord-265900-7lj4bfli	19	8	proteasome	proteasome	VBN
cord-265900-7lj4bfli	19	9	system	system	NN
cord-265900-7lj4bfli	19	10	(	(	-LRB-
cord-265900-7lj4bfli	19	11	UPS	UPS	NNP
cord-265900-7lj4bfli	19	12	)	)	-RRB-
cord-265900-7lj4bfli	19	13	is	be	VBZ
cord-265900-7lj4bfli	19	14	the	the	DT
cord-265900-7lj4bfli	19	15	major	major	JJ
cord-265900-7lj4bfli	19	16	intracellular	intracellular	JJ
cord-265900-7lj4bfli	19	17	pathway	pathway	NN
cord-265900-7lj4bfli	19	18	for	for	IN
cord-265900-7lj4bfli	19	19	degradation	degradation	NN
cord-265900-7lj4bfli	19	20	and	and	CC
cord-265900-7lj4bfli	19	21	functional	functional	JJ
cord-265900-7lj4bfli	19	22	modification	modification	NN
cord-265900-7lj4bfli	19	23	of	of	IN
cord-265900-7lj4bfli	19	24	cellular	cellular	JJ
cord-265900-7lj4bfli	19	25	proteins	protein	NNS
cord-265900-7lj4bfli	19	26	.	.	.
cord-265900-7lj4bfli	20	1	It	-PRON-	PRP
cord-265900-7lj4bfli	20	2	plays	play	VBZ
cord-265900-7lj4bfli	20	3	a	a	DT
cord-265900-7lj4bfli	20	4	key	key	JJ
cord-265900-7lj4bfli	20	5	role	role	NN
cord-265900-7lj4bfli	20	6	in	in	IN
cord-265900-7lj4bfli	20	7	the	the	DT
cord-265900-7lj4bfli	20	8	regulation	regulation	NN
cord-265900-7lj4bfli	20	9	of	of	IN
cord-265900-7lj4bfli	20	10	many	many	JJ
cord-265900-7lj4bfli	20	11	fundamental	fundamental	JJ
cord-265900-7lj4bfli	20	12	cellular	cellular	JJ
cord-265900-7lj4bfli	20	13	processes	process	NNS
cord-265900-7lj4bfli	20	14	,	,	,
cord-265900-7lj4bfli	20	15	including	include	VBG
cord-265900-7lj4bfli	20	16	apoptosis	apoptosis	NN
cord-265900-7lj4bfli	20	17	,	,	,
cord-265900-7lj4bfli	20	18	cell	cell	NN
cord-265900-7lj4bfli	20	19	cycle	cycle	NN
cord-265900-7lj4bfli	20	20	regulation	regulation	NN
cord-265900-7lj4bfli	20	21	,	,	,
cord-265900-7lj4bfli	20	22	signal	signal	NN
cord-265900-7lj4bfli	20	23	transduction	transduction	NN
cord-265900-7lj4bfli	20	24	,	,	,
cord-265900-7lj4bfli	20	25	antigen	antigen	NN
cord-265900-7lj4bfli	20	26	processing	processing	NN
cord-265900-7lj4bfli	20	27	,	,	,
cord-265900-7lj4bfli	20	28	and	and	CC
cord-265900-7lj4bfli	20	29	transcriptional	transcriptional	JJ
cord-265900-7lj4bfli	20	30	regulation	regulation	NN
cord-265900-7lj4bfli	20	31	[	[	-LRB-
cord-265900-7lj4bfli	20	32	1	1	CD
cord-265900-7lj4bfli	20	33	]	]	-RRB-
cord-265900-7lj4bfli	20	34	.	.	.
cord-265900-7lj4bfli	21	1	Ubiquitin	Ubiquitin	NNP
cord-265900-7lj4bfli	21	2	is	be	VBZ
cord-265900-7lj4bfli	21	3	a	a	DT
cord-265900-7lj4bfli	21	4	small	small	JJ
cord-265900-7lj4bfli	21	5	(	(	-LRB-
cord-265900-7lj4bfli	21	6	76	76	CD
cord-265900-7lj4bfli	21	7	amino	amino	JJ
cord-265900-7lj4bfli	21	8	acids	acid	NNS
cord-265900-7lj4bfli	21	9	)	)	-RRB-
cord-265900-7lj4bfli	21	10	and	and	CC
cord-265900-7lj4bfli	21	11	highly	highly	RB
cord-265900-7lj4bfli	21	12	conserved	conserved	JJ
cord-265900-7lj4bfli	21	13	protein	protein	NN
cord-265900-7lj4bfli	21	14	present	present	JJ
cord-265900-7lj4bfli	21	15	in	in	IN
cord-265900-7lj4bfli	21	16	almost	almost	RB
cord-265900-7lj4bfli	21	17	all	all	DT
cord-265900-7lj4bfli	21	18	eukaryotic	eukaryotic	JJ
cord-265900-7lj4bfli	21	19	cells	cell	NNS
cord-265900-7lj4bfli	21	20	.	.	.
cord-265900-7lj4bfli	22	1	For	for	IN
cord-265900-7lj4bfli	22	2	UPS	up	NNS
cord-265900-7lj4bfli	22	3	-	-	HYPH
cord-265900-7lj4bfli	22	4	mediated	mediate	VBN
cord-265900-7lj4bfli	22	5	proteolysis	proteolysis	NN
cord-265900-7lj4bfli	22	6	,	,	,
cord-265900-7lj4bfli	22	7	protein	protein	NN
cord-265900-7lj4bfli	22	8	substrates	substrate	NNS
cord-265900-7lj4bfli	22	9	are	be	VBP
cord-265900-7lj4bfli	22	10	first	first	RB
cord-265900-7lj4bfli	22	11	labeled	label	VBN
cord-265900-7lj4bfli	22	12	with	with	IN
cord-265900-7lj4bfli	22	13	ubiquitins	ubiquitin	NNS
cord-265900-7lj4bfli	22	14	(	(	-LRB-
cord-265900-7lj4bfli	22	15	a	a	DT
cord-265900-7lj4bfli	22	16	process	process	NN
cord-265900-7lj4bfli	22	17	called	call	VBN
cord-265900-7lj4bfli	22	18	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	22	19	)	)	-RRB-
cord-265900-7lj4bfli	22	20	,	,	,
cord-265900-7lj4bfli	22	21	and	and	CC
cord-265900-7lj4bfli	22	22	then	then	RB
cord-265900-7lj4bfli	22	23	recognized	recognize	VBD
cord-265900-7lj4bfli	22	24	and	and	CC
cord-265900-7lj4bfli	22	25	degraded	degrade	VBN
cord-265900-7lj4bfli	22	26	by	by	IN
cord-265900-7lj4bfli	22	27	the	the	DT
cord-265900-7lj4bfli	22	28	26S	26S	NNP
cord-265900-7lj4bfli	22	29	proteasome	proteasome	NN
cord-265900-7lj4bfli	22	30	[	[	-LRB-
cord-265900-7lj4bfli	22	31	1	1	CD
cord-265900-7lj4bfli	22	32	]	]	-RRB-
cord-265900-7lj4bfli	22	33	.	.	.
cord-265900-7lj4bfli	23	1	Ubiquitination	Ubiquitination	NNP
cord-265900-7lj4bfli	23	2	occurs	occur	VBZ
cord-265900-7lj4bfli	23	3	via	via	IN
cord-265900-7lj4bfli	23	4	a	a	DT
cord-265900-7lj4bfli	23	5	sequential	sequential	JJ
cord-265900-7lj4bfli	23	6	reaction	reaction	NN
cord-265900-7lj4bfli	23	7	mediated	mediate	VBN
cord-265900-7lj4bfli	23	8	by	by	IN
cord-265900-7lj4bfli	23	9	three	three	CD
cord-265900-7lj4bfli	23	10	enzymes	enzyme	NNS
cord-265900-7lj4bfli	23	11	,	,	,
cord-265900-7lj4bfli	23	12	i.e.	i.e.	FW
cord-265900-7lj4bfli	23	13	the	the	DT
cord-265900-7lj4bfli	23	14	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	23	15	-	-	HYPH
cord-265900-7lj4bfli	23	16	activating	activate	VBG
cord-265900-7lj4bfli	23	17	enzyme	enzyme	NN
cord-265900-7lj4bfli	23	18	(	(	-LRB-
cord-265900-7lj4bfli	23	19	E1	E1	NNP
cord-265900-7lj4bfli	23	20	)	)	-RRB-
cord-265900-7lj4bfli	23	21	,	,	,
cord-265900-7lj4bfli	23	22	the	the	DT
cord-265900-7lj4bfli	23	23	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	23	24	-	-	HYPH
cord-265900-7lj4bfli	23	25	conjugating	conjugate	VBG
cord-265900-7lj4bfli	23	26	enzyme	enzyme	NN
cord-265900-7lj4bfli	23	27	(	(	-LRB-
cord-265900-7lj4bfli	23	28	E2	E2	NNP
cord-265900-7lj4bfli	23	29	)	)	-RRB-
cord-265900-7lj4bfli	23	30	,	,	,
cord-265900-7lj4bfli	23	31	and	and	CC
cord-265900-7lj4bfli	23	32	the	the	DT
cord-265900-7lj4bfli	23	33	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	23	34	ligase	ligase	NN
cord-265900-7lj4bfli	23	35	(	(	-LRB-
cord-265900-7lj4bfli	23	36	E3	E3	NNP
cord-265900-7lj4bfli	23	37	)	)	-RRB-
cord-265900-7lj4bfli	23	38	.	.	.
cord-265900-7lj4bfli	24	1	The	the	DT
cord-265900-7lj4bfli	24	2	substrate	substrate	NN
cord-265900-7lj4bfli	24	3	specificity	specificity	NN
cord-265900-7lj4bfli	24	4	to	to	IN
cord-265900-7lj4bfli	24	5	the	the	DT
cord-265900-7lj4bfli	24	6	ubiquitin	ubiquitin	JJ
cord-265900-7lj4bfli	24	7	conjugation	conjugation	NN
cord-265900-7lj4bfli	24	8	system	system	NN
cord-265900-7lj4bfli	24	9	is	be	VBZ
cord-265900-7lj4bfli	24	10	determined	determine	VBN
cord-265900-7lj4bfli	24	11	by	by	IN
cord-265900-7lj4bfli	24	12	the	the	DT
cord-265900-7lj4bfli	24	13	E3	e3	NN
cord-265900-7lj4bfli	24	14	ligases	ligase	NNS
cord-265900-7lj4bfli	24	15	[	[	-LRB-
cord-265900-7lj4bfli	24	16	2	2	CD
cord-265900-7lj4bfli	24	17	]	]	-RRB-
cord-265900-7lj4bfli	24	18	.	.	.
cord-265900-7lj4bfli	25	1	After	after	IN
cord-265900-7lj4bfli	25	2	multiple	multiple	JJ
cord-265900-7lj4bfli	25	3	rounds	round	NNS
cord-265900-7lj4bfli	25	4	of	of	IN
cord-265900-7lj4bfli	25	5	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	25	6	,	,	,
cord-265900-7lj4bfli	25	7	a	a	DT
cord-265900-7lj4bfli	25	8	poly	poly	JJ
cord-265900-7lj4bfli	25	9	-	-	HYPH
cord-265900-7lj4bfli	25	10	ubiquitin	ubiquitin	JJ
cord-265900-7lj4bfli	25	11	chain	chain	NN
cord-265900-7lj4bfli	25	12	is	be	VBZ
cord-265900-7lj4bfli	25	13	formed	form	VBN
cord-265900-7lj4bfli	25	14	and	and	CC
cord-265900-7lj4bfli	25	15	serves	serve	VBZ
cord-265900-7lj4bfli	25	16	as	as	IN
cord-265900-7lj4bfli	25	17	a	a	DT
cord-265900-7lj4bfli	25	18	signal	signal	NN
cord-265900-7lj4bfli	25	19	for	for	IN
cord-265900-7lj4bfli	25	20	substrate	substrate	JJ
cord-265900-7lj4bfli	25	21	recognition	recognition	NN
cord-265900-7lj4bfli	25	22	and	and	CC
cord-265900-7lj4bfli	25	23	degradation	degradation	NN
cord-265900-7lj4bfli	25	24	by	by	IN
cord-265900-7lj4bfli	25	25	the	the	DT
cord-265900-7lj4bfli	25	26	26S	26S	NNP
cord-265900-7lj4bfli	25	27	proteasome	proteasome	NN
cord-265900-7lj4bfli	25	28	.	.	.
cord-265900-7lj4bfli	26	1	Ubiquitin	Ubiquitin	NNP
cord-265900-7lj4bfli	26	2	is	be	VBZ
cord-265900-7lj4bfli	26	3	then	then	RB
cord-265900-7lj4bfli	26	4	released	release	VBN
cord-265900-7lj4bfli	26	5	through	through	IN
cord-265900-7lj4bfli	26	6	the	the	DT
cord-265900-7lj4bfli	26	7	activities	activity	NNS
cord-265900-7lj4bfli	26	8	of	of	IN
cord-265900-7lj4bfli	26	9	deubiquitinating	deubiquitinating	NN
cord-265900-7lj4bfli	26	10	enzymes	enzyme	NNS
cord-265900-7lj4bfli	26	11	(	(	-LRB-
cord-265900-7lj4bfli	26	12	DUBs	dub	NNS
cord-265900-7lj4bfli	26	13	)	)	-RRB-
cord-265900-7lj4bfli	26	14	[	[	-LRB-
cord-265900-7lj4bfli	26	15	1	1	CD
cord-265900-7lj4bfli	26	16	,	,	,
cord-265900-7lj4bfli	26	17	2	2	CD
cord-265900-7lj4bfli	26	18	]	]	-RRB-
cord-265900-7lj4bfli	26	19	.	.	.
cord-265900-7lj4bfli	27	1	In	in	IN
cord-265900-7lj4bfli	27	2	addition	addition	NN
cord-265900-7lj4bfli	27	3	to	to	IN
cord-265900-7lj4bfli	27	4	ubiquitin	ubiquitin	JJ
cord-265900-7lj4bfli	27	5	-	-	HYPH
cord-265900-7lj4bfli	27	6	dependent	dependent	JJ
cord-265900-7lj4bfli	27	7	degradation	degradation	NN
cord-265900-7lj4bfli	27	8	,	,	,
cord-265900-7lj4bfli	27	9	some	some	DT
cord-265900-7lj4bfli	27	10	cellular	cellular	JJ
cord-265900-7lj4bfli	27	11	proteins	protein	NNS
cord-265900-7lj4bfli	27	12	can	can	MD
cord-265900-7lj4bfli	27	13	also	also	RB
cord-265900-7lj4bfli	27	14	be	be	VB
cord-265900-7lj4bfli	27	15	destroyed	destroy	VBN
cord-265900-7lj4bfli	27	16	by	by	IN
cord-265900-7lj4bfli	27	17	the	the	DT
cord-265900-7lj4bfli	27	18	proteasome	proteasome	NN
cord-265900-7lj4bfli	27	19	in	in	IN
cord-265900-7lj4bfli	27	20	a	a	DT
cord-265900-7lj4bfli	27	21	ubiquitin	ubiquitin	JJ
cord-265900-7lj4bfli	27	22	-	-	HYPH
cord-265900-7lj4bfli	27	23	independent	independent	JJ
cord-265900-7lj4bfli	27	24	manner	manner	NN
cord-265900-7lj4bfli	27	25	.	.	.
cord-265900-7lj4bfli	28	1	This	this	DT
cord-265900-7lj4bfli	28	2	process	process	NN
cord-265900-7lj4bfli	28	3	requires	require	VBZ
cord-265900-7lj4bfli	28	4	the	the	DT
cord-265900-7lj4bfli	28	5	function	function	NN
cord-265900-7lj4bfli	28	6	of	of	IN
cord-265900-7lj4bfli	28	7	proteasome	proteasome	NN
cord-265900-7lj4bfli	28	8	activator	activator	NN
cord-265900-7lj4bfli	28	9	28	28	CD
cord-265900-7lj4bfli	28	10	(	(	-LRB-
cord-265900-7lj4bfli	28	11	PA28	PA28	NNP
cord-265900-7lj4bfli	28	12	,	,	,
cord-265900-7lj4bfli	28	13	also	also	RB
cord-265900-7lj4bfli	28	14	known	know	VBN
cord-265900-7lj4bfli	28	15	at	at	IN
cord-265900-7lj4bfli	28	16	REG	REG	NNP
cord-265900-7lj4bfli	28	17	)	)	-RRB-
cord-265900-7lj4bfli	28	18	[	[	-LRB-
cord-265900-7lj4bfli	28	19	3	3	CD
cord-265900-7lj4bfli	28	20	]	]	-RRB-
cord-265900-7lj4bfli	28	21	.	.	.
cord-265900-7lj4bfli	29	1	Besides	besides	IN
cord-265900-7lj4bfli	29	2	the	the	DT
cord-265900-7lj4bfli	29	3	role	role	NN
cord-265900-7lj4bfli	29	4	of	of	IN
cord-265900-7lj4bfli	29	5	poly	poly	JJ
cord-265900-7lj4bfli	29	6	-	-	HYPH
cord-265900-7lj4bfli	29	7	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	29	8	(	(	-LRB-
cord-265900-7lj4bfli	29	9	most	most	RBS
cord-265900-7lj4bfli	29	10	commonly	commonly	RB
cord-265900-7lj4bfli	29	11	linked	link	VBN
cord-265900-7lj4bfli	29	12	with	with	IN
cord-265900-7lj4bfli	29	13	lysine	lysine	NN
cord-265900-7lj4bfli	29	14	48	48	CD
cord-265900-7lj4bfli	29	15	)	)	-RRB-
cord-265900-7lj4bfli	29	16	in	in	IN
cord-265900-7lj4bfli	29	17	proteasomal	proteasomal	JJ
cord-265900-7lj4bfli	29	18	degradation	degradation	NN
cord-265900-7lj4bfli	29	19	,	,	,
cord-265900-7lj4bfli	29	20	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	29	21	is	be	VBZ
cord-265900-7lj4bfli	29	22	also	also	RB
cord-265900-7lj4bfli	29	23	involved	involve	VBN
cord-265900-7lj4bfli	29	24	in	in	IN
cord-265900-7lj4bfli	29	25	regulating	regulate	VBG
cord-265900-7lj4bfli	29	26	protein	protein	NN
cord-265900-7lj4bfli	29	27	function	function	NN
cord-265900-7lj4bfli	29	28	without	without	IN
cord-265900-7lj4bfli	29	29	targeting	target	VBG
cord-265900-7lj4bfli	29	30	for	for	IN
cord-265900-7lj4bfli	29	31	degradation	degradation	NN
cord-265900-7lj4bfli	29	32	.	.	.
cord-265900-7lj4bfli	30	1	Mono	mono	NN
cord-265900-7lj4bfli	30	2	-	-	HYPH
cord-265900-7lj4bfli	30	3	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	30	4	or	or	CC
cord-265900-7lj4bfli	30	5	lysine	lysine	NN
cord-265900-7lj4bfli	30	6	63-linked	63-linked	CD
cord-265900-7lj4bfli	30	7	poly	poly	JJ
cord-265900-7lj4bfli	30	8	-	-	HYPH
cord-265900-7lj4bfli	30	9	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	30	10	has	have	VBZ
cord-265900-7lj4bfli	30	11	been	be	VBN
cord-265900-7lj4bfli	30	12	shown	show	VBN
cord-265900-7lj4bfli	30	13	to	to	TO
cord-265900-7lj4bfli	30	14	play	play	VB
cord-265900-7lj4bfli	30	15	key	key	JJ
cord-265900-7lj4bfli	30	16	roles	role	NNS
cord-265900-7lj4bfli	30	17	in	in	IN
cord-265900-7lj4bfli	30	18	a	a	DT
cord-265900-7lj4bfli	30	19	wide	wide	JJ
cord-265900-7lj4bfli	30	20	range	range	NN
cord-265900-7lj4bfli	30	21	of	of	IN
cord-265900-7lj4bfli	30	22	cellular	cellular	JJ
cord-265900-7lj4bfli	30	23	functions	function	NNS
cord-265900-7lj4bfli	30	24	,	,	,
cord-265900-7lj4bfli	30	25	including	include	VBG
cord-265900-7lj4bfli	30	26	protein	protein	NN
cord-265900-7lj4bfli	30	27	subcellular	subcellular	JJ
cord-265900-7lj4bfli	30	28	localization	localization	NN
cord-265900-7lj4bfli	30	29	,	,	,
cord-265900-7lj4bfli	30	30	transcription	transcription	NN
cord-265900-7lj4bfli	30	31	,	,	,
cord-265900-7lj4bfli	30	32	DNA	dna	NN
cord-265900-7lj4bfli	30	33	repair	repair	NN
cord-265900-7lj4bfli	30	34	,	,	,
cord-265900-7lj4bfli	30	35	and	and	CC
cord-265900-7lj4bfli	30	36	signal	signal	NN
cord-265900-7lj4bfli	30	37	transduction	transduction	NN
cord-265900-7lj4bfli	30	38	[	[	-LRB-
cord-265900-7lj4bfli	30	39	2	2	CD
cord-265900-7lj4bfli	30	40	,	,	,
cord-265900-7lj4bfli	30	41	4	4	CD
cord-265900-7lj4bfli	30	42	]	]	-RRB-
cord-265900-7lj4bfli	30	43	.	.	.
cord-265900-7lj4bfli	31	1	Apart	apart	RB
cord-265900-7lj4bfli	31	2	from	from	IN
cord-265900-7lj4bfli	31	3	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	31	4	,	,	,
cord-265900-7lj4bfli	31	5	target	target	NN
cord-265900-7lj4bfli	31	6	proteins	protein	NNS
cord-265900-7lj4bfli	31	7	can	can	MD
cord-265900-7lj4bfli	31	8	also	also	RB
cord-265900-7lj4bfli	31	9	be	be	VB
cord-265900-7lj4bfli	31	10	post	post	NN
cord-265900-7lj4bfli	31	11	-	-	JJ
cord-265900-7lj4bfli	31	12	translationally	translationally	RB
cord-265900-7lj4bfli	31	13	modified	modify	VBN
cord-265900-7lj4bfli	31	14	by	by	IN
cord-265900-7lj4bfli	31	15	several	several	JJ
cord-265900-7lj4bfli	31	16	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	31	17	-	-	HYPH
cord-265900-7lj4bfli	31	18	like	like	JJ
cord-265900-7lj4bfli	31	19	proteins	protein	NNS
cord-265900-7lj4bfli	31	20	,	,	,
cord-265900-7lj4bfli	31	21	such	such	JJ
cord-265900-7lj4bfli	31	22	as	as	IN
cord-265900-7lj4bfli	31	23	the	the	DT
cord-265900-7lj4bfli	31	24	small	small	JJ
cord-265900-7lj4bfli	31	25	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	31	26	-	-	HYPH
cord-265900-7lj4bfli	31	27	like	like	JJ
cord-265900-7lj4bfli	31	28	modifiers	modifier	NNS
cord-265900-7lj4bfli	31	29	(	(	-LRB-
cord-265900-7lj4bfli	31	30	SUMO	SUMO	NNP
cord-265900-7lj4bfli	31	31	,	,	,
cord-265900-7lj4bfli	32	1	four	four	CD
cord-265900-7lj4bfli	32	2	isoforms	isoform	NNS
cord-265900-7lj4bfli	32	3	are	be	VBP
cord-265900-7lj4bfli	32	4	identified	identify	VBN
cord-265900-7lj4bfli	32	5	in	in	IN
cord-265900-7lj4bfli	32	6	humans	human	NNS
cord-265900-7lj4bfli	32	7	,	,	,
cord-265900-7lj4bfli	32	8	SUMO1	SUMO1	NNP
cord-265900-7lj4bfli	32	9	,	,	,
cord-265900-7lj4bfli	32	10	SUMO2	sumo2	XX
cord-265900-7lj4bfli	32	11	,	,	,
cord-265900-7lj4bfli	32	12	SU	SU	NNP
cord-265900-7lj4bfli	32	13	-	-	HYPH
cord-265900-7lj4bfli	32	14	MO3	MO3	NNP
cord-265900-7lj4bfli	32	15	,	,	,
cord-265900-7lj4bfli	32	16	and	and	CC
cord-265900-7lj4bfli	32	17	SUMO4	SUMO4	NNP
cord-265900-7lj4bfli	32	18	)	)	-RRB-
cord-265900-7lj4bfli	33	1	[	[	-LRB-
cord-265900-7lj4bfli	33	2	5	5	CD
cord-265900-7lj4bfli	33	3	,	,	,
cord-265900-7lj4bfli	33	4	6	6	CD
cord-265900-7lj4bfli	33	5	]	]	-RRB-
cord-265900-7lj4bfli	33	6	and	and	CC
cord-265900-7lj4bfli	33	7	the	the	DT
cord-265900-7lj4bfli	33	8	interferon	interferon	NN
cord-265900-7lj4bfli	33	9	-	-	HYPH
cord-265900-7lj4bfli	33	10	stimulated	stimulate	VBN
cord-265900-7lj4bfli	33	11	gene	gene	NN
cord-265900-7lj4bfli	33	12	15	15	CD
cord-265900-7lj4bfli	33	13	(	(	-LRB-
cord-265900-7lj4bfli	33	14	ISG15	isg15	NN
cord-265900-7lj4bfli	33	15	)	)	-RRB-
cord-265900-7lj4bfli	33	16	[	[	-LRB-
cord-265900-7lj4bfli	33	17	7	7	CD
cord-265900-7lj4bfli	33	18	,	,	,
cord-265900-7lj4bfli	33	19	8	8	CD
cord-265900-7lj4bfli	33	20	]	]	-RRB-
cord-265900-7lj4bfli	33	21	.	.	.
cord-265900-7lj4bfli	34	1	Protein	protein	NN
cord-265900-7lj4bfli	34	2	modification	modification	NN
cord-265900-7lj4bfli	34	3	mediated	mediate	VBN
cord-265900-7lj4bfli	34	4	by	by	IN
cord-265900-7lj4bfli	34	5	SUMO	SUMO	NNP
cord-265900-7lj4bfli	34	6	and	and	CC
cord-265900-7lj4bfli	34	7	ISG15	ISG15	NNP
cord-265900-7lj4bfli	34	8	(	(	-LRB-
cord-265900-7lj4bfli	34	9	termed	term	VBN
cord-265900-7lj4bfli	34	10	sumoylation	sumoylation	NN
cord-265900-7lj4bfli	34	11	and	and	CC
cord-265900-7lj4bfli	34	12	ISGylation	isgylation	NN
cord-265900-7lj4bfli	34	13	,	,	,
cord-265900-7lj4bfli	34	14	respectively	respectively	RB
cord-265900-7lj4bfli	34	15	)	)	-RRB-
cord-265900-7lj4bfli	34	16	occurs	occur	VBZ
cord-265900-7lj4bfli	34	17	in	in	IN
cord-265900-7lj4bfli	34	18	a	a	DT
cord-265900-7lj4bfli	34	19	matter	matter	NN
cord-265900-7lj4bfli	34	20	similar	similar	JJ
cord-265900-7lj4bfli	34	21	to	to	IN
cord-265900-7lj4bfli	34	22	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	34	23	that	that	WDT
cord-265900-7lj4bfli	34	24	requires	require	VBZ
cord-265900-7lj4bfli	34	25	an	an	DT
cord-265900-7lj4bfli	34	26	enzymatic	enzymatic	JJ
cord-265900-7lj4bfli	34	27	cascade	cascade	NN
cord-265900-7lj4bfli	34	28	of	of	IN
cord-265900-7lj4bfli	34	29	E1	e1	NN
cord-265900-7lj4bfli	34	30	(	(	-LRB-
cord-265900-7lj4bfli	34	31	Aos1	Aos1	NNP
cord-265900-7lj4bfli	34	32	/	/	SYM
cord-265900-7lj4bfli	34	33	Uba2	Uba2	NNP
cord-265900-7lj4bfli	34	34	heterodimer	heterodimer	NN
cord-265900-7lj4bfli	34	35	for	for	IN
cord-265900-7lj4bfli	34	36	SUMO	SUMO	NNP
cord-265900-7lj4bfli	34	37	and	and	CC
cord-265900-7lj4bfli	34	38	UBE1L	ube1l	NN
cord-265900-7lj4bfli	34	39	for	for	IN
cord-265900-7lj4bfli	34	40	ISG15	isg15	NN
cord-265900-7lj4bfli	34	41	)	)	-RRB-
cord-265900-7lj4bfli	34	42	,	,	,
cord-265900-7lj4bfli	34	43	E2	E2	NNP
cord-265900-7lj4bfli	34	44	(	(	-LRB-
cord-265900-7lj4bfli	34	45	Ubc9	Ubc9	NNP
cord-265900-7lj4bfli	34	46	for	for	IN
cord-265900-7lj4bfli	34	47	SUMO	SUMO	NNP
cord-265900-7lj4bfli	34	48	;	;	:
cord-265900-7lj4bfli	34	49	UbcH8	UbcH8	NNP
cord-265900-7lj4bfli	34	50	and	and	CC
cord-265900-7lj4bfli	34	51	UbcH6	ubch6	CD
cord-265900-7lj4bfli	34	52	for	for	IN
cord-265900-7lj4bfli	34	53	ISG15	isg15	NN
cord-265900-7lj4bfli	34	54	)	)	-RRB-
cord-265900-7lj4bfli	34	55	,	,	,
cord-265900-7lj4bfli	34	56	and	and	CC
cord-265900-7lj4bfli	34	57	E3	E3	NNP
cord-265900-7lj4bfli	34	58	[	[	-LRB-
cord-265900-7lj4bfli	34	59	5	5	CD
cord-265900-7lj4bfli	34	60	]	]	-RRB-
cord-265900-7lj4bfli	34	61	[	[	-LRB-
cord-265900-7lj4bfli	34	62	6	6	CD
cord-265900-7lj4bfli	34	63	]	]	-RRB-
cord-265900-7lj4bfli	34	64	[	[	-LRB-
cord-265900-7lj4bfli	34	65	7	7	CD
cord-265900-7lj4bfli	34	66	]	]	-RRB-
cord-265900-7lj4bfli	34	67	[	[	-LRB-
cord-265900-7lj4bfli	34	68	8	8	CD
cord-265900-7lj4bfli	34	69	]	]	-RRB-
cord-265900-7lj4bfli	34	70	.	.	.
cord-265900-7lj4bfli	35	1	There	there	EX
cord-265900-7lj4bfli	35	2	are	be	VBP
cord-265900-7lj4bfli	35	3	currently	currently	RB
cord-265900-7lj4bfli	35	4	three	three	CD
cord-265900-7lj4bfli	35	5	identified	identify	VBN
cord-265900-7lj4bfli	35	6	SUMO	SUMO	NNP
cord-265900-7lj4bfli	35	7	E3s	e3s	NN
cord-265900-7lj4bfli	35	8	,	,	,
cord-265900-7lj4bfli	35	9	that	that	RB
cord-265900-7lj4bfli	35	10	is	is	RB
cord-265900-7lj4bfli	35	11	,	,	,
cord-265900-7lj4bfli	35	12	RanBP2	RanBP2	NNP
cord-265900-7lj4bfli	35	13	,	,	,
cord-265900-7lj4bfli	35	14	PIAS	PIAS	NNP
cord-265900-7lj4bfli	35	15	and	and	CC
cord-265900-7lj4bfli	35	16	the	the	DT
cord-265900-7lj4bfli	35	17	Polycomb	Polycomb	NNP
cord-265900-7lj4bfli	35	18	protein	protein	NN
cord-265900-7lj4bfli	35	19	Pc2	pc2	CD
cord-265900-7lj4bfli	35	20	[	[	-LRB-
cord-265900-7lj4bfli	35	21	5	5	CD
cord-265900-7lj4bfli	35	22	,	,	,
cord-265900-7lj4bfli	35	23	6	6	CD
cord-265900-7lj4bfli	35	24	]	]	-RRB-
cord-265900-7lj4bfli	35	25	and	and	CC
cord-265900-7lj4bfli	35	26	three	three	CD
cord-265900-7lj4bfli	35	27	known	know	VBN
cord-265900-7lj4bfli	35	28	ISG15	isg15	NN
cord-265900-7lj4bfli	35	29	E3s	e3s	NN
cord-265900-7lj4bfli	35	30	,	,	,
cord-265900-7lj4bfli	36	1	that	that	DT
cord-265900-7lj4bfli	36	2	is	is	RB
cord-265900-7lj4bfli	36	3	,	,	,
cord-265900-7lj4bfli	36	4	HERC5	HERC5	NNP
cord-265900-7lj4bfli	36	5	,	,	,
cord-265900-7lj4bfli	36	6	HHARI	HHARI	NNP
cord-265900-7lj4bfli	36	7	,	,	,
cord-265900-7lj4bfli	36	8	and	and	CC
cord-265900-7lj4bfli	36	9	TRIM25	TRIM25	NNP
cord-265900-7lj4bfli	36	10	[	[	-LRB-
cord-265900-7lj4bfli	36	11	7	7	CD
cord-265900-7lj4bfli	36	12	,	,	,
cord-265900-7lj4bfli	36	13	8	8	CD
cord-265900-7lj4bfli	36	14	]	]	-RRB-
cord-265900-7lj4bfli	36	15	.	.	.
cord-265900-7lj4bfli	37	1	These	these	DT
cord-265900-7lj4bfli	37	2	processes	process	NNS
cord-265900-7lj4bfli	37	3	can	can	MD
cord-265900-7lj4bfli	37	4	be	be	VB
cord-265900-7lj4bfli	37	5	reversed	reverse	VBN
cord-265900-7lj4bfli	37	6	via	via	IN
cord-265900-7lj4bfli	37	7	the	the	DT
cord-265900-7lj4bfli	37	8	action	action	NN
cord-265900-7lj4bfli	37	9	of	of	IN
cord-265900-7lj4bfli	37	10	de	de	NN
cord-265900-7lj4bfli	37	11	-	-	NN
cord-265900-7lj4bfli	37	12	sumoylating	sumoylating	NN
cord-265900-7lj4bfli	37	13	or	or	CC
cord-265900-7lj4bfli	37	14	de	de	JJ
cord-265900-7lj4bfli	37	15	-	-	JJ
cord-265900-7lj4bfli	37	16	ISGylating	isgylate	VBG
cord-265900-7lj4bfli	37	17	enzymes	enzyme	NNS
cord-265900-7lj4bfli	37	18	.	.	.
cord-265900-7lj4bfli	38	1	The	the	DT
cord-265900-7lj4bfli	38	2	sumoylation	sumoylation	NN
cord-265900-7lj4bfli	38	3	and	and	CC
cord-265900-7lj4bfli	38	4	ISGylation	isgylation	JJ
cord-265900-7lj4bfli	38	5	conjugation	conjugation	NN
cord-265900-7lj4bfli	38	6	systems	system	NNS
cord-265900-7lj4bfli	38	7	have	have	VBP
cord-265900-7lj4bfli	38	8	been	be	VBN
cord-265900-7lj4bfli	38	9	implicated	implicate	VBN
cord-265900-7lj4bfli	38	10	in	in	IN
cord-265900-7lj4bfli	38	11	the	the	DT
cord-265900-7lj4bfli	38	12	regulation	regulation	NN
cord-265900-7lj4bfli	38	13	of	of	IN
cord-265900-7lj4bfli	38	14	many	many	JJ
cord-265900-7lj4bfli	38	15	cellular	cellular	JJ
cord-265900-7lj4bfli	38	16	functions	function	NNS
cord-265900-7lj4bfli	38	17	,	,	,
cord-265900-7lj4bfli	38	18	including	include	VBG
cord-265900-7lj4bfli	38	19	transcriptional	transcriptional	JJ
cord-265900-7lj4bfli	38	20	regulation	regulation	NN
cord-265900-7lj4bfli	38	21	,	,	,
cord-265900-7lj4bfli	38	22	anti	anti	JJ
cord-265900-7lj4bfli	38	23	-	-	JJ
cord-265900-7lj4bfli	38	24	viral	viral	JJ
cord-265900-7lj4bfli	38	25	immune	immune	JJ
cord-265900-7lj4bfli	38	26	response	response	NN
cord-265900-7lj4bfli	38	27	,	,	,
cord-265900-7lj4bfli	38	28	signaling	signal	VBG
cord-265900-7lj4bfli	38	29	pathways	pathway	NNS
cord-265900-7lj4bfli	38	30	,	,	,
cord-265900-7lj4bfli	38	31	and	and	CC
cord-265900-7lj4bfli	38	32	vesicular	vesicular	JJ
cord-265900-7lj4bfli	38	33	trafficking	trafficking	NN
cord-265900-7lj4bfli	38	34	[	[	-LRB-
cord-265900-7lj4bfli	38	35	5	5	CD
cord-265900-7lj4bfli	38	36	]	]	-RRB-
cord-265900-7lj4bfli	38	37	[	[	-LRB-
cord-265900-7lj4bfli	38	38	6	6	CD
cord-265900-7lj4bfli	38	39	]	]	-RRB-
cord-265900-7lj4bfli	38	40	[	[	-LRB-
cord-265900-7lj4bfli	38	41	7	7	CD
cord-265900-7lj4bfli	38	42	]	]	-RRB-
cord-265900-7lj4bfli	38	43	[	[	-LRB-
cord-265900-7lj4bfli	38	44	8	8	CD
cord-265900-7lj4bfli	38	45	]	]	-RRB-
cord-265900-7lj4bfli	38	46	.	.	.
cord-265900-7lj4bfli	39	1	become	become	VBN
cord-265900-7lj4bfli	39	2	increasingly	increasingly	RB
cord-265900-7lj4bfli	39	3	evident	evident	JJ
cord-265900-7lj4bfli	39	4	that	that	IN
cord-265900-7lj4bfli	39	5	viruses	virus	NNS
cord-265900-7lj4bfli	39	6	interact	interact	VBP
cord-265900-7lj4bfli	39	7	with	with	IN
cord-265900-7lj4bfli	39	8	the	the	DT
cord-265900-7lj4bfli	39	9	UPS	up	NNS
cord-265900-7lj4bfli	39	10	at	at	IN
cord-265900-7lj4bfli	39	11	multiple	multiple	JJ
cord-265900-7lj4bfli	39	12	levels	level	NNS
cord-265900-7lj4bfli	39	13	.	.	.
cord-265900-7lj4bfli	40	1	They	-PRON-	PRP
cord-265900-7lj4bfli	40	2	can	can	MD
cord-265900-7lj4bfli	40	3	either	either	CC
cord-265900-7lj4bfli	40	4	directly	directly	RB
cord-265900-7lj4bfli	40	5	encode	encode	VB
cord-265900-7lj4bfli	40	6	proteins	protein	NNS
cord-265900-7lj4bfli	40	7	with	with	IN
cord-265900-7lj4bfli	40	8	E3-like	e3-like	NN
cord-265900-7lj4bfli	40	9	or	or	CC
cord-265900-7lj4bfli	40	10	DUB	dub	NN
cord-265900-7lj4bfli	40	11	-	-	HYPH
cord-265900-7lj4bfli	40	12	like	like	JJ
cord-265900-7lj4bfli	40	13	activities	activity	NNS
cord-265900-7lj4bfli	40	14	or	or	CC
cord-265900-7lj4bfli	40	15	modify	modify	VB
cord-265900-7lj4bfli	40	16	specific	specific	JJ
cord-265900-7lj4bfli	40	17	aspects	aspect	NNS
cord-265900-7lj4bfli	40	18	of	of	IN
cord-265900-7lj4bfli	40	19	the	the	DT
cord-265900-7lj4bfli	40	20	host	host	NN
cord-265900-7lj4bfli	40	21	UPS	UPS	NNP
cord-265900-7lj4bfli	40	22	function	function	NN
cord-265900-7lj4bfli	40	23	for	for	IN
cord-265900-7lj4bfli	40	24	their	-PRON-	PRP$
cord-265900-7lj4bfli	40	25	own	own	JJ
cord-265900-7lj4bfli	40	26	advantages	advantage	NNS
cord-265900-7lj4bfli	40	27	[	[	-LRB-
cord-265900-7lj4bfli	40	28	9	9	CD
cord-265900-7lj4bfli	40	29	]	]	-RRB-
cord-265900-7lj4bfli	40	30	[	[	-LRB-
cord-265900-7lj4bfli	40	31	10	10	CD
cord-265900-7lj4bfli	40	32	]	]	-RRB-
cord-265900-7lj4bfli	40	33	[	[	-LRB-
cord-265900-7lj4bfli	40	34	11	11	CD
cord-265900-7lj4bfli	40	35	]	]	-RRB-
cord-265900-7lj4bfli	40	36	.	.	.
cord-265900-7lj4bfli	41	1	The	the	DT
cord-265900-7lj4bfli	41	2	UPS	UPS	NNP
cord-265900-7lj4bfli	41	3	plays	play	VBZ
cord-265900-7lj4bfli	41	4	a	a	DT
cord-265900-7lj4bfli	41	5	dual	dual	JJ
cord-265900-7lj4bfli	41	6	role	role	NN
cord-265900-7lj4bfli	41	7	in	in	IN
cord-265900-7lj4bfli	41	8	viral	viral	JJ
cord-265900-7lj4bfli	41	9	pathogenesis	pathogenesis	NN
cord-265900-7lj4bfli	41	10	:	:	:
cord-265900-7lj4bfli	41	11	it	-PRON-	PRP
cord-265900-7lj4bfli	41	12	has	have	VBZ
cord-265900-7lj4bfli	41	13	both	both	CC
cord-265900-7lj4bfli	41	14	pro	pro	JJ
cord-265900-7lj4bfli	41	15	-	-	JJ
cord-265900-7lj4bfli	41	16	viral	viral	JJ
cord-265900-7lj4bfli	41	17	and	and	CC
cord-265900-7lj4bfli	41	18	anti	anti	JJ
cord-265900-7lj4bfli	41	19	-	-	JJ
cord-265900-7lj4bfli	41	20	viral	viral	JJ
cord-265900-7lj4bfli	41	21	effects	effect	NNS
cord-265900-7lj4bfli	41	22	[	[	-LRB-
cord-265900-7lj4bfli	41	23	9	9	CD
cord-265900-7lj4bfli	41	24	]	]	-RRB-
cord-265900-7lj4bfli	41	25	[	[	-LRB-
cord-265900-7lj4bfli	41	26	10	10	CD
cord-265900-7lj4bfli	41	27	]	]	-RRB-
cord-265900-7lj4bfli	41	28	[	[	-LRB-
cord-265900-7lj4bfli	41	29	11	11	CD
cord-265900-7lj4bfli	41	30	]	]	-RRB-
cord-265900-7lj4bfli	41	31	.	.	.
cord-265900-7lj4bfli	42	1	The	the	DT
cord-265900-7lj4bfli	42	2	UPS	up	NNS
cord-265900-7lj4bfli	42	3	can	can	MD
cord-265900-7lj4bfli	42	4	enhance	enhance	VB
cord-265900-7lj4bfli	42	5	the	the	DT
cord-265900-7lj4bfli	42	6	function	function	NN
cord-265900-7lj4bfli	42	7	of	of	IN
cord-265900-7lj4bfli	42	8	viral	viral	JJ
cord-265900-7lj4bfli	42	9	proteins	protein	NNS
cord-265900-7lj4bfli	42	10	via	via	IN
cord-265900-7lj4bfli	42	11	post	post	JJ
cord-265900-7lj4bfli	42	12	-	-	JJ
cord-265900-7lj4bfli	42	13	translational	translational	JJ
cord-265900-7lj4bfli	42	14	modification	modification	NN
cord-265900-7lj4bfli	42	15	mediated	mediate	VBN
cord-265900-7lj4bfli	42	16	by	by	IN
cord-265900-7lj4bfli	42	17	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	42	18	or	or	CC
cord-265900-7lj4bfli	42	19	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	42	20	-	-	HYPH
cord-265900-7lj4bfli	42	21	like	like	JJ
cord-265900-7lj4bfli	42	22	proteins	protein	NNS
cord-265900-7lj4bfli	42	23	.	.	.
cord-265900-7lj4bfli	43	1	It	-PRON-	PRP
cord-265900-7lj4bfli	43	2	can	can	MD
cord-265900-7lj4bfli	43	3	also	also	RB
cord-265900-7lj4bfli	43	4	facilitate	facilitate	VB
cord-265900-7lj4bfli	43	5	viral	viral	JJ
cord-265900-7lj4bfli	43	6	infection	infection	NN
cord-265900-7lj4bfli	43	7	through	through	IN
cord-265900-7lj4bfli	43	8	controlling	control	VBG
cord-265900-7lj4bfli	43	9	the	the	DT
cord-265900-7lj4bfli	43	10	stability	stability	NN
cord-265900-7lj4bfli	43	11	of	of	IN
cord-265900-7lj4bfli	43	12	both	both	DT
cord-265900-7lj4bfli	43	13	viral	viral	JJ
cord-265900-7lj4bfli	43	14	and	and	CC
cord-265900-7lj4bfli	43	15	cellular	cellular	JJ
cord-265900-7lj4bfli	43	16	proteins	protein	NNS
cord-265900-7lj4bfli	43	17	.	.	.
cord-265900-7lj4bfli	44	1	However	however	RB
cord-265900-7lj4bfli	44	2	,	,	,
cord-265900-7lj4bfli	44	3	on	on	IN
cord-265900-7lj4bfli	44	4	the	the	DT
cord-265900-7lj4bfli	44	5	other	other	JJ
cord-265900-7lj4bfli	44	6	hand	hand	NN
cord-265900-7lj4bfli	44	7	,	,	,
cord-265900-7lj4bfli	44	8	UPS	UPS	NNP
cord-265900-7lj4bfli	44	9	-	-	HYPH
cord-265900-7lj4bfli	44	10	mediated	mediate	VBN
cord-265900-7lj4bfli	44	11	viral	viral	JJ
cord-265900-7lj4bfli	44	12	protein	protein	NN
cord-265900-7lj4bfli	44	13	degradation	degradation	NN
cord-265900-7lj4bfli	44	14	may	may	MD
cord-265900-7lj4bfli	44	15	also	also	RB
cord-265900-7lj4bfli	44	16	constitute	constitute	VB
cord-265900-7lj4bfli	44	17	a	a	DT
cord-265900-7lj4bfli	44	18	host	host	NN
cord-265900-7lj4bfli	44	19	defense	defense	NN
cord-265900-7lj4bfli	44	20	process	process	NN
cord-265900-7lj4bfli	44	21	against	against	IN
cord-265900-7lj4bfli	44	22	viral	viral	JJ
cord-265900-7lj4bfli	44	23	infections	infection	NNS
cord-265900-7lj4bfli	44	24	.	.	.
cord-265900-7lj4bfli	45	1	Viruses	virus	NNS
cord-265900-7lj4bfli	45	2	have	have	VBP
cord-265900-7lj4bfli	45	3	developed	develop	VBN
cord-265900-7lj4bfli	45	4	sophisticated	sophisticated	JJ
cord-265900-7lj4bfli	45	5	mechanisms	mechanism	NNS
cord-265900-7lj4bfli	45	6	to	to	TO
cord-265900-7lj4bfli	45	7	counteract	counteract	VB
cord-265900-7lj4bfli	45	8	this	this	DT
cord-265900-7lj4bfli	45	9	anti	anti	JJ
cord-265900-7lj4bfli	45	10	-	-	JJ
cord-265900-7lj4bfli	45	11	viral	viral	JJ
cord-265900-7lj4bfli	45	12	immune	immune	JJ
cord-265900-7lj4bfli	45	13	response	response	NN
cord-265900-7lj4bfli	45	14	.	.	.
cord-265900-7lj4bfli	46	1	This	this	DT
cord-265900-7lj4bfli	46	2	review	review	NN
cord-265900-7lj4bfli	46	3	will	will	MD
cord-265900-7lj4bfli	46	4	focus	focus	VB
cord-265900-7lj4bfli	46	5	on	on	IN
cord-265900-7lj4bfli	46	6	how	how	WRB
cord-265900-7lj4bfli	46	7	viruses	virus	NNS
cord-265900-7lj4bfli	46	8	evolve	evolve	VBP
cord-265900-7lj4bfli	46	9	to	to	TO
cord-265900-7lj4bfli	46	10	interact	interact	VB
cord-265900-7lj4bfli	46	11	with	with	IN
cord-265900-7lj4bfli	46	12	the	the	DT
cord-265900-7lj4bfli	46	13	host	host	NN
cord-265900-7lj4bfli	46	14	UPS	UPS	NNP
cord-265900-7lj4bfli	46	15	to	to	TO
cord-265900-7lj4bfli	46	16	favor	favor	VB
cord-265900-7lj4bfli	46	17	their	-PRON-	PRP$
cord-265900-7lj4bfli	46	18	propagation	propagation	NN
cord-265900-7lj4bfli	46	19	,	,	,
cord-265900-7lj4bfli	46	20	to	to	TO
cord-265900-7lj4bfli	46	21	escape	escape	VB
cord-265900-7lj4bfli	46	22	host	host	NN
cord-265900-7lj4bfli	46	23	immune	immune	JJ
cord-265900-7lj4bfli	46	24	response	response	NN
cord-265900-7lj4bfli	46	25	,	,	,
cord-265900-7lj4bfli	46	26	and	and	CC
cord-265900-7lj4bfli	46	27	contribute	contribute	VB
cord-265900-7lj4bfli	46	28	to	to	IN
cord-265900-7lj4bfli	46	29	viral	viral	JJ
cord-265900-7lj4bfli	46	30	pathogenesis	pathogenesis	NN
cord-265900-7lj4bfli	46	31	.	.	.
cord-265900-7lj4bfli	47	1	Some	some	DT
cord-265900-7lj4bfli	47	2	cellular	cellular	JJ
cord-265900-7lj4bfli	47	3	proteins	protein	NNS
cord-265900-7lj4bfli	47	4	can	can	MD
cord-265900-7lj4bfli	47	5	function	function	VB
cord-265900-7lj4bfli	47	6	as	as	IN
cord-265900-7lj4bfli	47	7	restriction	restriction	NN
cord-265900-7lj4bfli	47	8	factors	factor	NNS
cord-265900-7lj4bfli	47	9	to	to	TO
cord-265900-7lj4bfli	47	10	limit	limit	VB
cord-265900-7lj4bfli	47	11	viral	viral	JJ
cord-265900-7lj4bfli	47	12	infection	infection	NN
cord-265900-7lj4bfli	47	13	by	by	IN
cord-265900-7lj4bfli	47	14	directly	directly	RB
cord-265900-7lj4bfli	47	15	inhibiting	inhibit	VBG
cord-265900-7lj4bfli	47	16	viral	viral	JJ
cord-265900-7lj4bfli	47	17	replication	replication	NN
cord-265900-7lj4bfli	47	18	or	or	CC
cord-265900-7lj4bfli	47	19	through	through	IN
cord-265900-7lj4bfli	47	20	controlling	control	VBG
cord-265900-7lj4bfli	47	21	the	the	DT
cord-265900-7lj4bfli	47	22	state	state	NN
cord-265900-7lj4bfli	47	23	of	of	IN
cord-265900-7lj4bfli	47	24	their	-PRON-	PRP$
cord-265900-7lj4bfli	47	25	infected	infect	VBN
cord-265900-7lj4bfli	47	26	cells	cell	NNS
cord-265900-7lj4bfli	47	27	,	,	,
cord-265900-7lj4bfli	47	28	in	in	IN
cord-265900-7lj4bfli	47	29	particular	particular	JJ
cord-265900-7lj4bfli	47	30	cell	cell	NN
cord-265900-7lj4bfli	47	31	survival	survival	NN
cord-265900-7lj4bfli	47	32	/	/	,
cord-265900-7lj4bfli	47	33	apoptosis	apoptosis	NN
cord-265900-7lj4bfli	47	34	and	and	CC
cord-265900-7lj4bfli	47	35	cell	cell	NN
cord-265900-7lj4bfli	47	36	cycle	cycle	NN
cord-265900-7lj4bfli	47	37	progression	progression	NN
cord-265900-7lj4bfli	47	38	.	.	.
cord-265900-7lj4bfli	48	1	For	for	IN
cord-265900-7lj4bfli	48	2	example	example	NN
cord-265900-7lj4bfli	48	3	,	,	,
cord-265900-7lj4bfli	48	4	the	the	DT
cord-265900-7lj4bfli	48	5	tumor	tumor	NN
cord-265900-7lj4bfli	48	6	suppressor	suppressor	NN
cord-265900-7lj4bfli	48	7	protein	protein	NN
cord-265900-7lj4bfli	48	8	p53	p53	NN
cord-265900-7lj4bfli	48	9	has	have	VBZ
cord-265900-7lj4bfli	48	10	been	be	VBN
cord-265900-7lj4bfli	48	11	shown	show	VBN
cord-265900-7lj4bfli	48	12	to	to	TO
cord-265900-7lj4bfli	48	13	block	block	VB
cord-265900-7lj4bfli	48	14	viral	viral	JJ
cord-265900-7lj4bfli	48	15	replication	replication	NN
cord-265900-7lj4bfli	48	16	by	by	IN
cord-265900-7lj4bfli	48	17	suppressing	suppress	VBG
cord-265900-7lj4bfli	48	18	viral	viral	JJ
cord-265900-7lj4bfli	48	19	gene	gene	NN
cord-265900-7lj4bfli	48	20	activation	activation	NN
cord-265900-7lj4bfli	48	21	and/or	and/or	CC
cord-265900-7lj4bfli	48	22	through	through	IN
cord-265900-7lj4bfli	48	23	promoting	promote	VBG
cord-265900-7lj4bfli	48	24	host	host	NN
cord-265900-7lj4bfli	48	25	cell	cell	NN
cord-265900-7lj4bfli	48	26	apoptosis	apoptosis	NN
cord-265900-7lj4bfli	48	27	[	[	-LRB-
cord-265900-7lj4bfli	48	28	12	12	CD
cord-265900-7lj4bfli	48	29	,	,	,
cord-265900-7lj4bfli	48	30	13	13	CD
cord-265900-7lj4bfli	48	31	]	]	-RRB-
cord-265900-7lj4bfli	48	32	.	.	.
cord-265900-7lj4bfli	49	1	Viruses	virus	NNS
cord-265900-7lj4bfli	49	2	can	can	MD
cord-265900-7lj4bfli	49	3	recruit	recruit	VB
cord-265900-7lj4bfli	49	4	the	the	DT
cord-265900-7lj4bfli	49	5	cellular	cellular	JJ
cord-265900-7lj4bfli	49	6	E3	e3	NN
cord-265900-7lj4bfli	49	7	ligases	ligase	NNS
cord-265900-7lj4bfli	49	8	to	to	TO
cord-265900-7lj4bfli	49	9	target	target	VB
cord-265900-7lj4bfli	49	10	anti	anti	JJ
cord-265900-7lj4bfli	49	11	-	-	JJ
cord-265900-7lj4bfli	49	12	viral	viral	JJ
cord-265900-7lj4bfli	49	13	proteins	protein	NNS
cord-265900-7lj4bfli	49	14	for	for	IN
cord-265900-7lj4bfli	49	15	degradation	degradation	NN
cord-265900-7lj4bfli	49	16	.	.	.
cord-265900-7lj4bfli	50	1	Several	several	JJ
cord-265900-7lj4bfli	50	2	proteins	protein	NNS
cord-265900-7lj4bfli	50	3	encoded	encode	VBN
cord-265900-7lj4bfli	50	4	by	by	IN
cord-265900-7lj4bfli	50	5	DNA	dna	NN
cord-265900-7lj4bfli	50	6	tumor	tumor	NN
cord-265900-7lj4bfli	50	7	viruses	virus	NNS
cord-265900-7lj4bfli	50	8	,	,	,
cord-265900-7lj4bfli	50	9	such	such	JJ
cord-265900-7lj4bfli	50	10	as	as	IN
cord-265900-7lj4bfli	50	11	the	the	DT
cord-265900-7lj4bfli	50	12	human	human	JJ
cord-265900-7lj4bfli	50	13	papillomavirus	papillomavirus	NN
cord-265900-7lj4bfli	50	14	(	(	-LRB-
cord-265900-7lj4bfli	50	15	HPV	HPV	NNP
cord-265900-7lj4bfli	50	16	)	)	-RRB-
cord-265900-7lj4bfli	50	17	E6	E6	NNP
cord-265900-7lj4bfli	50	18	and	and	CC
cord-265900-7lj4bfli	50	19	E7	E7	NNP
cord-265900-7lj4bfli	50	20	proteins	protein	NNS
cord-265900-7lj4bfli	50	21	[	[	-LRB-
cord-265900-7lj4bfli	50	22	14	14	CD
cord-265900-7lj4bfli	50	23	,	,	,
cord-265900-7lj4bfli	50	24	15	15	CD
cord-265900-7lj4bfli	50	25	]	]	-RRB-
cord-265900-7lj4bfli	50	26	and	and	CC
cord-265900-7lj4bfli	50	27	the	the	DT
cord-265900-7lj4bfli	50	28	adenovirus	adenovirus	NN
cord-265900-7lj4bfli	50	29	E1B55k	E1B55k	NNP
cord-265900-7lj4bfli	50	30	/	/	SYM
cord-265900-7lj4bfli	50	31	E4orf6	E4orf6	NNP
cord-265900-7lj4bfli	50	32	proteins	protein	NNS
cord-265900-7lj4bfli	50	33	[	[	-LRB-
cord-265900-7lj4bfli	50	34	16	16	CD
cord-265900-7lj4bfli	50	35	]	]	-RRB-
cord-265900-7lj4bfli	50	36	,	,	,
cord-265900-7lj4bfli	50	37	have	have	VBP
cord-265900-7lj4bfli	50	38	been	be	VBN
cord-265900-7lj4bfli	50	39	shown	show	VBN
cord-265900-7lj4bfli	50	40	to	to	TO
cord-265900-7lj4bfli	50	41	induce	induce	VB
cord-265900-7lj4bfli	50	42	the	the	DT
cord-265900-7lj4bfli	50	43	assembly	assembly	NN
cord-265900-7lj4bfli	50	44	of	of	IN
cord-265900-7lj4bfli	50	45	an	an	DT
cord-265900-7lj4bfli	50	46	E3	e3	NN
cord-265900-7lj4bfli	50	47	ligase	ligase	NN
cord-265900-7lj4bfli	50	48	complex	complex	NN
cord-265900-7lj4bfli	50	49	that	that	WDT
cord-265900-7lj4bfli	50	50	contains	contain	VBZ
cord-265900-7lj4bfli	50	51	both	both	DT
cord-265900-7lj4bfli	50	52	viral	viral	JJ
cord-265900-7lj4bfli	50	53	protein	protein	NN
cord-265900-7lj4bfli	50	54	and	and	CC
cord-265900-7lj4bfli	50	55	cellular	cellular	JJ
cord-265900-7lj4bfli	50	56	E3	e3	NN
cord-265900-7lj4bfli	50	57	to	to	TO
cord-265900-7lj4bfli	50	58	catalyze	catalyze	VB
cord-265900-7lj4bfli	50	59	the	the	DT
cord-265900-7lj4bfli	50	60	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	50	61	of	of	IN
cord-265900-7lj4bfli	50	62	p53	p53	NN
cord-265900-7lj4bfli	50	63	and	and	CC
cord-265900-7lj4bfli	50	64	subsequent	subsequent	JJ
cord-265900-7lj4bfli	50	65	degradation	degradation	NN
cord-265900-7lj4bfli	50	66	by	by	IN
cord-265900-7lj4bfli	50	67	the	the	DT
cord-265900-7lj4bfli	50	68	proteasome	proteasome	NN
cord-265900-7lj4bfli	50	69	.	.	.
cord-265900-7lj4bfli	51	1	For	for	IN
cord-265900-7lj4bfli	51	2	instance	instance	NN
cord-265900-7lj4bfli	51	3	,	,	,
cord-265900-7lj4bfli	51	4	the	the	DT
cord-265900-7lj4bfli	51	5	HPV	HPV	NNP
cord-265900-7lj4bfli	51	6	E6	e6	NN
cord-265900-7lj4bfli	51	7	protein	protein	NN
cord-265900-7lj4bfli	51	8	binds	bind	VBZ
cord-265900-7lj4bfli	51	9	to	to	IN
cord-265900-7lj4bfli	51	10	the	the	DT
cord-265900-7lj4bfli	51	11	cellular	cellular	JJ
cord-265900-7lj4bfli	51	12	E3	e3	NN
cord-265900-7lj4bfli	51	13	ligase	ligase	NN
cord-265900-7lj4bfli	51	14	E6-associated	e6-associate	VBN
cord-265900-7lj4bfli	51	15	protein	protein	NN
cord-265900-7lj4bfli	51	16	(	(	-LRB-
cord-265900-7lj4bfli	51	17	E6AP	e6ap	RB
cord-265900-7lj4bfli	51	18	)	)	-RRB-
cord-265900-7lj4bfli	51	19	to	to	TO
cord-265900-7lj4bfli	51	20	form	form	VB
cord-265900-7lj4bfli	51	21	an	an	DT
cord-265900-7lj4bfli	51	22	E3	e3	NN
cord-265900-7lj4bfli	51	23	complex	complex	NN
cord-265900-7lj4bfli	51	24	to	to	TO
cord-265900-7lj4bfli	51	25	mediate	mediate	VB
cord-265900-7lj4bfli	51	26	p53	p53	NN
cord-265900-7lj4bfli	51	27	degradation	degradation	NN
cord-265900-7lj4bfli	51	28	[	[	-LRB-
cord-265900-7lj4bfli	51	29	14	14	CD
cord-265900-7lj4bfli	51	30	]	]	-RRB-
cord-265900-7lj4bfli	51	31	.	.	.
cord-265900-7lj4bfli	52	1	In	in	IN
cord-265900-7lj4bfli	52	2	addition	addition	NN
cord-265900-7lj4bfli	52	3	to	to	IN
cord-265900-7lj4bfli	52	4	p53	p53	NN
cord-265900-7lj4bfli	52	5	,	,	,
cord-265900-7lj4bfli	52	6	the	the	DT
cord-265900-7lj4bfli	52	7	HPV	HPV	NNP
cord-265900-7lj4bfli	52	8	E7	E7	NNP
cord-265900-7lj4bfli	52	9	protein	protein	NN
cord-265900-7lj4bfli	52	10	also	also	RB
cord-265900-7lj4bfli	52	11	targets	target	VBZ
cord-265900-7lj4bfli	52	12	another	another	DT
cord-265900-7lj4bfli	52	13	tumor	tumor	NN
cord-265900-7lj4bfli	52	14	suppressor	suppressor	NN
cord-265900-7lj4bfli	52	15	protein	protein	NN
cord-265900-7lj4bfli	52	16	,	,	,
cord-265900-7lj4bfli	52	17	retinoblastoma	retinoblastoma	NN
cord-265900-7lj4bfli	52	18	protein	protein	NN
cord-265900-7lj4bfli	52	19	(	(	-LRB-
cord-265900-7lj4bfli	52	20	pRb	pRb	NNP
cord-265900-7lj4bfli	52	21	)	)	-RRB-
cord-265900-7lj4bfli	52	22	,	,	,
cord-265900-7lj4bfli	52	23	for	for	IN
cord-265900-7lj4bfli	52	24	proteasomal	proteasomal	JJ
cord-265900-7lj4bfli	52	25	degradation	degradation	NN
cord-265900-7lj4bfli	52	26	,	,	,
cord-265900-7lj4bfli	52	27	which	which	WDT
cord-265900-7lj4bfli	52	28	is	be	VBZ
cord-265900-7lj4bfli	52	29	mediated	mediate	VBN
cord-265900-7lj4bfli	52	30	through	through	IN
cord-265900-7lj4bfli	52	31	a	a	DT
cord-265900-7lj4bfli	52	32	cullin	cullin	NNP
cord-265900-7lj4bfli	52	33	E3	E3	NNP
cord-265900-7lj4bfli	52	34	complex	complex	NN
cord-265900-7lj4bfli	52	35	[	[	-LRB-
cord-265900-7lj4bfli	52	36	17	17	CD
cord-265900-7lj4bfli	52	37	]	]	-RRB-
cord-265900-7lj4bfli	52	38	.	.	.
cord-265900-7lj4bfli	53	1	Beside	beside	IN
cord-265900-7lj4bfli	53	2	ubiquitin	ubiquitin	JJ
cord-265900-7lj4bfli	53	3	conjugation	conjugation	NN
cord-265900-7lj4bfli	53	4	,	,	,
cord-265900-7lj4bfli	53	5	the	the	DT
cord-265900-7lj4bfli	53	6	expression	expression	NN
cord-265900-7lj4bfli	53	7	of	of	IN
cord-265900-7lj4bfli	53	8	p53	p53	NN
cord-265900-7lj4bfli	53	9	can	can	MD
cord-265900-7lj4bfli	53	10	also	also	RB
cord-265900-7lj4bfli	53	11	be	be	VB
cord-265900-7lj4bfli	53	12	regulated	regulate	VBN
cord-265900-7lj4bfli	53	13	at	at	IN
cord-265900-7lj4bfli	53	14	the	the	DT
cord-265900-7lj4bfli	53	15	levels	level	NNS
cord-265900-7lj4bfli	53	16	of	of	IN
cord-265900-7lj4bfli	53	17	deubiquitinating	deubiquitinating	NN
cord-265900-7lj4bfli	53	18	and	and	CC
cord-265900-7lj4bfli	53	19	proteasome	proteasome	NN
cord-265900-7lj4bfli	53	20	activity	activity	NN
cord-265900-7lj4bfli	53	21	.	.	.
cord-265900-7lj4bfli	54	1	It	-PRON-	PRP
cord-265900-7lj4bfli	54	2	was	be	VBD
cord-265900-7lj4bfli	54	3	shown	show	VBN
cord-265900-7lj4bfli	54	4	that	that	IN
cord-265900-7lj4bfli	54	5	the	the	DT
cord-265900-7lj4bfli	54	6	Epstein	Epstein	NNP
cord-265900-7lj4bfli	54	7	-	-	HYPH
cord-265900-7lj4bfli	54	8	Barr	Barr	NNP
cord-265900-7lj4bfli	54	9	nuclear	nuclear	JJ
cord-265900-7lj4bfli	54	10	antigen	antigen	NN
cord-265900-7lj4bfli	54	11	1	1	CD
cord-265900-7lj4bfli	54	12	interacts	interact	VBZ
cord-265900-7lj4bfli	54	13	with	with	IN
cord-265900-7lj4bfli	54	14	the	the	DT
cord-265900-7lj4bfli	54	15	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	54	16	-	-	HYPH
cord-265900-7lj4bfli	54	17	specific	specific	JJ
cord-265900-7lj4bfli	54	18	protease	protease	NN
cord-265900-7lj4bfli	54	19	7	7	CD
cord-265900-7lj4bfli	55	1	(	(	-LRB-
cord-265900-7lj4bfli	55	2	USP7	USP7	NNP
cord-265900-7lj4bfli	55	3	,	,	,
cord-265900-7lj4bfli	55	4	a	a	DT
cord-265900-7lj4bfli	55	5	cellular	cellular	JJ
cord-265900-7lj4bfli	55	6	DUB	dub	NN
cord-265900-7lj4bfli	55	7	)	)	-RRB-
cord-265900-7lj4bfli	55	8	to	to	TO
cord-265900-7lj4bfli	55	9	enhance	enhance	VB
cord-265900-7lj4bfli	55	10	p53	p53	NN
cord-265900-7lj4bfli	55	11	degradation	degradation	NN
cord-265900-7lj4bfli	55	12	,	,	,
cord-265900-7lj4bfli	55	13	presumably	presumably	RB
cord-265900-7lj4bfli	55	14	through	through	IN
cord-265900-7lj4bfli	55	15	inhibiting	inhibit	VBG
cord-265900-7lj4bfli	55	16	the	the	DT
cord-265900-7lj4bfli	55	17	activity	activity	NN
cord-265900-7lj4bfli	55	18	of	of	IN
cord-265900-7lj4bfli	55	19	USP7	USP7	NNP
cord-265900-7lj4bfli	55	20	and	and	CC
cord-265900-7lj4bfli	55	21	thereby	thereby	RB
cord-265900-7lj4bfli	55	22	preventing	prevent	VBG
cord-265900-7lj4bfli	55	23	p53	p53	NN
cord-265900-7lj4bfli	55	24	deubiquitination	deubiquitination	NN
cord-265900-7lj4bfli	55	25	[	[	-LRB-
cord-265900-7lj4bfli	55	26	18	18	CD
cord-265900-7lj4bfli	55	27	]	]	-RRB-
cord-265900-7lj4bfli	55	28	.	.	.
cord-265900-7lj4bfli	56	1	In	in	IN
cord-265900-7lj4bfli	56	2	the	the	DT
cord-265900-7lj4bfli	56	3	case	case	NN
cord-265900-7lj4bfli	56	4	of	of	IN
cord-265900-7lj4bfli	56	5	coxsackievirus	coxsackievirus	NNP
cord-265900-7lj4bfli	56	6	infection	infection	NN
cord-265900-7lj4bfli	56	7	,	,	,
cord-265900-7lj4bfli	56	8	it	-PRON-	PRP
cord-265900-7lj4bfli	56	9	was	be	VBD
cord-265900-7lj4bfli	56	10	found	find	VBN
cord-265900-7lj4bfli	56	11	that	that	IN
cord-265900-7lj4bfli	56	12	proteasome	proteasome	VBN
cord-265900-7lj4bfli	56	13	activator	activator	NN
cord-265900-7lj4bfli	56	14	PA28	PA28	NNP
cord-265900-7lj4bfli	56	15	g	g	NNP
cord-265900-7lj4bfli	56	16	is	be	VBZ
cord-265900-7lj4bfli	56	17	relocated	relocate	VBN
cord-265900-7lj4bfli	56	18	from	from	IN
cord-265900-7lj4bfli	56	19	the	the	DT
cord-265900-7lj4bfli	56	20	nucleus	nucleus	NN
cord-265900-7lj4bfli	56	21	to	to	IN
cord-265900-7lj4bfli	56	22	the	the	DT
cord-265900-7lj4bfli	56	23	cytoplasm	cytoplasm	NN
cord-265900-7lj4bfli	56	24	where	where	WRB
cord-265900-7lj4bfli	56	25	it	-PRON-	PRP
cord-265900-7lj4bfli	56	26	facilitates	facilitate	VBZ
cord-265900-7lj4bfli	56	27	the	the	DT
cord-265900-7lj4bfli	56	28	turnover	turnover	NN
cord-265900-7lj4bfli	56	29	of	of	IN
cord-265900-7lj4bfli	56	30	p53	p53	NN
cord-265900-7lj4bfli	56	31	through	through	IN
cord-265900-7lj4bfli	56	32	the	the	DT
cord-265900-7lj4bfli	56	33	proteasome	proteasome	NN
cord-265900-7lj4bfli	56	34	[	[	-LRB-
cord-265900-7lj4bfli	56	35	19	19	CD
cord-265900-7lj4bfli	56	36	]	]	-RRB-
cord-265900-7lj4bfli	56	37	.	.	.
cord-265900-7lj4bfli	57	1	Another	another	DT
cord-265900-7lj4bfli	57	2	example	example	NN
cord-265900-7lj4bfli	57	3	of	of	IN
cord-265900-7lj4bfli	57	4	viral	viral	JJ
cord-265900-7lj4bfli	57	5	manipulation	manipulation	NN
cord-265900-7lj4bfli	57	6	of	of	IN
cord-265900-7lj4bfli	57	7	the	the	DT
cord-265900-7lj4bfli	57	8	UPS	up	NNS
cord-265900-7lj4bfli	57	9	for	for	IN
cord-265900-7lj4bfli	57	10	cellular	cellular	JJ
cord-265900-7lj4bfli	57	11	protein	protein	NN
cord-265900-7lj4bfli	57	12	degradation	degradation	NN
cord-265900-7lj4bfli	57	13	is	be	VBZ
cord-265900-7lj4bfli	57	14	provided	provide	VBN
cord-265900-7lj4bfli	57	15	by	by	IN
cord-265900-7lj4bfli	57	16	lentivirus	lentivirus	NN
cord-265900-7lj4bfli	57	17	destruction	destruction	NN
cord-265900-7lj4bfli	57	18	of	of	IN
cord-265900-7lj4bfli	57	19	the	the	DT
cord-265900-7lj4bfli	57	20	SAMHD1	SAMHD1	NNS
cord-265900-7lj4bfli	57	21	(	(	-LRB-
cord-265900-7lj4bfli	57	22	sterile	sterile	JJ
cord-265900-7lj4bfli	57	23	alpha	alpha	NN
cord-265900-7lj4bfli	57	24	motif	motif	NN
cord-265900-7lj4bfli	57	25	domain	domain	NN
cord-265900-7lj4bfli	57	26	-	-	:
cord-265900-7lj4bfli	57	27	and	and	CC
cord-265900-7lj4bfli	57	28	histidine	histidine	NN
cord-265900-7lj4bfli	57	29	-	-	HYPH
cord-265900-7lj4bfli	57	30	aspartate	aspartate	NN
cord-265900-7lj4bfli	57	31	domain	domain	NN
cord-265900-7lj4bfli	57	32	-	-	HYPH
cord-265900-7lj4bfli	57	33	containing	contain	VBG
cord-265900-7lj4bfli	57	34	protein	protein	NN
cord-265900-7lj4bfli	57	35	1	1	CD
cord-265900-7lj4bfli	57	36	)	)	-RRB-
cord-265900-7lj4bfli	57	37	protein	protein	NN
cord-265900-7lj4bfli	57	38	.	.	.
cord-265900-7lj4bfli	58	1	SAMHD1	SAMHD1	NNPS
cord-265900-7lj4bfli	58	2	is	be	VBZ
cord-265900-7lj4bfli	58	3	a	a	DT
cord-265900-7lj4bfli	58	4	cellular	cellular	JJ
cord-265900-7lj4bfli	58	5	deoxynucleoside	deoxynucleoside	NN
cord-265900-7lj4bfli	58	6	(	(	-LRB-
cord-265900-7lj4bfli	58	7	dNTP	dNTP	NNP
cord-265900-7lj4bfli	58	8	)	)	-RRB-
cord-265900-7lj4bfli	58	9	triphosphohydrolase	triphosphohydrolase	NN
cord-265900-7lj4bfli	58	10	that	that	WDT
cord-265900-7lj4bfli	58	11	inhibits	inhibit	VBZ
cord-265900-7lj4bfli	58	12	human	human	JJ
cord-265900-7lj4bfli	58	13	immunodeficiency	immunodeficiency	NN
cord-265900-7lj4bfli	58	14	virus	virus	NN
cord-265900-7lj4bfli	58	15	(	(	-LRB-
cord-265900-7lj4bfli	58	16	HIV	HIV	NNP
cord-265900-7lj4bfli	58	17	)	)	-RRB-
cord-265900-7lj4bfli	58	18	infection	infection	NN
cord-265900-7lj4bfli	58	19	by	by	IN
cord-265900-7lj4bfli	58	20	suppressing	suppress	VBG
cord-265900-7lj4bfli	58	21	the	the	DT
cord-265900-7lj4bfli	58	22	activity	activity	NN
cord-265900-7lj4bfli	58	23	of	of	IN
cord-265900-7lj4bfli	58	24	reverse	reverse	JJ
cord-265900-7lj4bfli	58	25	transcriptase	transcriptase	NN
cord-265900-7lj4bfli	58	26	through	through	IN
cord-265900-7lj4bfli	58	27	depleting	deplete	VBG
cord-265900-7lj4bfli	58	28	cellular	cellular	JJ
cord-265900-7lj4bfli	58	29	dNTPs	dntps	CD
cord-265900-7lj4bfli	58	30	[	[	-LRB-
cord-265900-7lj4bfli	58	31	20	20	CD
cord-265900-7lj4bfli	58	32	]	]	-RRB-
cord-265900-7lj4bfli	58	33	.	.	.
cord-265900-7lj4bfli	59	1	It	-PRON-	PRP
cord-265900-7lj4bfli	59	2	has	have	VBZ
cord-265900-7lj4bfli	59	3	been	be	VBN
cord-265900-7lj4bfli	59	4	recently	recently	RB
cord-265900-7lj4bfli	59	5	demonstrated	demonstrate	VBN
cord-265900-7lj4bfli	59	6	that	that	IN
cord-265900-7lj4bfli	59	7	the	the	DT
cord-265900-7lj4bfli	59	8	viral	viral	JJ
cord-265900-7lj4bfli	59	9	protein	protein	NN
cord-265900-7lj4bfli	59	10	X	x	NN
cord-265900-7lj4bfli	59	11	encoded	encode	VBN
cord-265900-7lj4bfli	59	12	by	by	IN
cord-265900-7lj4bfli	59	13	HIV-2	HIV-2	NNP
cord-265900-7lj4bfli	59	14	and	and	CC
cord-265900-7lj4bfli	59	15	some	some	DT
cord-265900-7lj4bfli	59	16	simian	simian	JJ
cord-265900-7lj4bfli	59	17	immunodeficiency	immunodeficiency	NN
cord-265900-7lj4bfli	59	18	virus	virus	NN
cord-265900-7lj4bfli	59	19	redirects	redirect	VBZ
cord-265900-7lj4bfli	59	20	a	a	DT
cord-265900-7lj4bfli	59	21	cullin	cullin	NN
cord-265900-7lj4bfli	59	22	-	-	HYPH
cord-265900-7lj4bfli	59	23	RING	ring	NN
cord-265900-7lj4bfli	59	24	E3	e3	NN
cord-265900-7lj4bfli	59	25	ligase	ligase	NN
cord-265900-7lj4bfli	59	26	to	to	IN
cord-265900-7lj4bfli	59	27	SAMHD1	SAMHD1	NNS
cord-265900-7lj4bfli	59	28	to	to	TO
cord-265900-7lj4bfli	59	29	target	target	VB
cord-265900-7lj4bfli	59	30	it	-PRON-	PRP
cord-265900-7lj4bfli	59	31	for	for	IN
cord-265900-7lj4bfli	59	32	proteasomal	proteasomal	JJ
cord-265900-7lj4bfli	59	33	degradation	degradation	NN
cord-265900-7lj4bfli	59	34	in	in	IN
cord-265900-7lj4bfli	59	35	the	the	DT
cord-265900-7lj4bfli	59	36	nucleus	nucleus	NN
cord-265900-7lj4bfli	59	37	[	[	-LRB-
cord-265900-7lj4bfli	59	38	21	21	CD
cord-265900-7lj4bfli	59	39	]	]	-RRB-
cord-265900-7lj4bfli	59	40	.	.	.
cord-265900-7lj4bfli	60	1	A	a	DT
cord-265900-7lj4bfli	60	2	common	common	JJ
cord-265900-7lj4bfli	60	3	strategy	strategy	NN
cord-265900-7lj4bfli	60	4	for	for	IN
cord-265900-7lj4bfli	60	5	viral	viral	JJ
cord-265900-7lj4bfli	60	6	evasion	evasion	NN
cord-265900-7lj4bfli	60	7	of	of	IN
cord-265900-7lj4bfli	60	8	host	host	NN
cord-265900-7lj4bfli	60	9	immune	immune	JJ
cord-265900-7lj4bfli	60	10	surveillance	surveillance	NN
cord-265900-7lj4bfli	60	11	is	be	VBZ
cord-265900-7lj4bfli	60	12	to	to	TO
cord-265900-7lj4bfli	60	13	target	target	VB
cord-265900-7lj4bfli	60	14	host	host	NN
cord-265900-7lj4bfli	60	15	immune	immune	JJ
cord-265900-7lj4bfli	60	16	adaptor	adaptor	NN
cord-265900-7lj4bfli	60	17	and	and	CC
cord-265900-7lj4bfli	60	18	signaling	signal	VBG
cord-265900-7lj4bfli	60	19	molecules	molecule	NNS
cord-265900-7lj4bfli	60	20	(	(	-LRB-
cord-265900-7lj4bfli	60	21	e.g.	e.g.	IN
cord-265900-7lj4bfli	60	22	molecules	molecule	NNS
cord-265900-7lj4bfli	60	23	involved	involve	VBN
cord-265900-7lj4bfli	60	24	in	in	IN
cord-265900-7lj4bfli	60	25	type	type	NN
cord-265900-7lj4bfli	61	1	I	-PRON-	PRP
cord-265900-7lj4bfli	62	1	interferon	interferon	NNP
cord-265900-7lj4bfli	62	2	(	(	-LRB-
cord-265900-7lj4bfli	62	3	IFN	IFN	NNP
cord-265900-7lj4bfli	62	4	)	)	-RRB-
cord-265900-7lj4bfli	62	5	response	response	NN
cord-265900-7lj4bfli	62	6	and	and	CC
cord-265900-7lj4bfli	62	7	MHC	MHC	NNP
cord-265900-7lj4bfli	62	8	class	class	NN
cord-265900-7lj4bfli	62	9	I	-PRON-	PRP
cord-265900-7lj4bfli	62	10	antigen	antigen	NN
cord-265900-7lj4bfli	62	11	presentation	presentation	NN
cord-265900-7lj4bfli	62	12	)	)	-RRB-
cord-265900-7lj4bfli	62	13	for	for	IN
cord-265900-7lj4bfli	62	14	proteasomal	proteasomal	JJ
cord-265900-7lj4bfli	62	15	degradation	degradation	NN
cord-265900-7lj4bfli	62	16	or	or	CC
cord-265900-7lj4bfli	62	17	to	to	TO
cord-265900-7lj4bfli	62	18	prevent	prevent	VB
cord-265900-7lj4bfli	62	19	the	the	DT
cord-265900-7lj4bfli	62	20	destruction	destruction	NN
cord-265900-7lj4bfli	62	21	of	of	IN
cord-265900-7lj4bfli	62	22	immune	immune	NN
cord-265900-7lj4bfli	62	23	-	-	HYPH
cord-265900-7lj4bfli	62	24	related	relate	VBN
cord-265900-7lj4bfli	62	25	transcription	transcription	NN
cord-265900-7lj4bfli	62	26	factor	factor	NN
cord-265900-7lj4bfli	62	27	inhibitors	inhibitor	NNS
cord-265900-7lj4bfli	62	28	(	(	-LRB-
cord-265900-7lj4bfli	62	29	e.g.	e.g.	RB
cord-265900-7lj4bfli	62	30	IkBa	IkBa	NNP
cord-265900-7lj4bfli	62	31	,	,	,
cord-265900-7lj4bfli	62	32	an	an	DT
cord-265900-7lj4bfli	62	33	inhibitor	inhibitor	NN
cord-265900-7lj4bfli	62	34	of	of	IN
cord-265900-7lj4bfli	62	35	the	the	DT
cord-265900-7lj4bfli	62	36	nuclear	nuclear	JJ
cord-265900-7lj4bfli	62	37	factor	factor	NN
cord-265900-7lj4bfli	62	38	kappa	kappa	NN
cord-265900-7lj4bfli	62	39	B	B	NNP
cord-265900-7lj4bfli	62	40	(	(	-LRB-
cord-265900-7lj4bfli	62	41	NFkB	nfkb	UH
cord-265900-7lj4bfli	62	42	)	)	-RRB-
cord-265900-7lj4bfli	62	43	by	by	IN
cord-265900-7lj4bfli	62	44	sequestering	sequester	VBG
cord-265900-7lj4bfli	62	45	it	-PRON-	PRP
cord-265900-7lj4bfli	62	46	in	in	IN
cord-265900-7lj4bfli	62	47	the	the	DT
cord-265900-7lj4bfli	62	48	cytoplasm	cytoplasm	NN
cord-265900-7lj4bfli	62	49	)	)	-RRB-
cord-265900-7lj4bfli	62	50	.	.	.
cord-265900-7lj4bfli	63	1	Early	early	JJ
cord-265900-7lj4bfli	63	2	studies	study	NNS
cord-265900-7lj4bfli	63	3	have	have	VBP
cord-265900-7lj4bfli	63	4	revealed	reveal	VBN
cord-265900-7lj4bfli	63	5	that	that	IN
cord-265900-7lj4bfli	63	6	human	human	JJ
cord-265900-7lj4bfli	63	7	cytomegalovirus	cytomegalovirus	NN
cord-265900-7lj4bfli	63	8	(	(	-LRB-
cord-265900-7lj4bfli	63	9	HCMV)-encoded	hcmv)-encoded	CD
cord-265900-7lj4bfli	63	10	proteins	protein	NNS
cord-265900-7lj4bfli	63	11	,	,	,
cord-265900-7lj4bfli	63	12	US2	US2	NNP
cord-265900-7lj4bfli	63	13	and	and	CC
cord-265900-7lj4bfli	63	14	US11	US11	NNP
cord-265900-7lj4bfli	63	15	,	,	,
cord-265900-7lj4bfli	63	16	induce	induce	VB
cord-265900-7lj4bfli	63	17	the	the	DT
cord-265900-7lj4bfli	63	18	dislocation	dislocation	NN
cord-265900-7lj4bfli	63	19	of	of	IN
cord-265900-7lj4bfli	63	20	MHC	MHC	NNP
cord-265900-7lj4bfli	63	21	class	class	NN
cord-265900-7lj4bfli	63	22	I	-PRON-	PRP
cord-265900-7lj4bfli	63	23	from	from	IN
cord-265900-7lj4bfli	63	24	the	the	DT
cord-265900-7lj4bfli	63	25	endoplasmic	endoplasmic	NN
cord-265900-7lj4bfli	63	26	reticulum	reticulum	NN
cord-265900-7lj4bfli	63	27	to	to	IN
cord-265900-7lj4bfli	63	28	the	the	DT
cord-265900-7lj4bfli	63	29	cytosol	cytosol	NN
cord-265900-7lj4bfli	63	30	,	,	,
cord-265900-7lj4bfli	63	31	where	where	WRB
cord-265900-7lj4bfli	63	32	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	63	33	and	and	CC
cord-265900-7lj4bfli	63	34	proteasomal	proteasomal	JJ
cord-265900-7lj4bfli	63	35	degradation	degradation	NN
cord-265900-7lj4bfli	63	36	of	of	IN
cord-265900-7lj4bfli	63	37	MHC	MHC	NNP
cord-265900-7lj4bfli	63	38	molecules	molecule	NNS
cord-265900-7lj4bfli	63	39	take	take	VBP
cord-265900-7lj4bfli	63	40	place	place	NN
cord-265900-7lj4bfli	63	41	[	[	-LRB-
cord-265900-7lj4bfli	63	42	22	22	CD
cord-265900-7lj4bfli	63	43	,	,	,
cord-265900-7lj4bfli	63	44	23	23	CD
cord-265900-7lj4bfli	63	45	]	]	-RRB-
cord-265900-7lj4bfli	63	46	.	.	.
cord-265900-7lj4bfli	64	1	Recent	recent	JJ
cord-265900-7lj4bfli	64	2	work	work	NN
cord-265900-7lj4bfli	64	3	has	have	VBZ
cord-265900-7lj4bfli	64	4	identified	identify	VBN
cord-265900-7lj4bfli	64	5	additional	additional	JJ
cord-265900-7lj4bfli	64	6	cellular	cellular	JJ
cord-265900-7lj4bfli	64	7	targets	target	NNS
cord-265900-7lj4bfli	64	8	(	(	-LRB-
cord-265900-7lj4bfli	64	9	integrin	integrin	VB
cord-265900-7lj4bfli	64	10	a	a	DT
cord-265900-7lj4bfli	64	11	-	-	HYPH
cord-265900-7lj4bfli	64	12	chains	chain	NNS
cord-265900-7lj4bfli	64	13	,	,	,
cord-265900-7lj4bfli	64	14	CD112	CD112	NNP
cord-265900-7lj4bfli	64	15	,	,	,
cord-265900-7lj4bfli	64	16	interleukin-12	interleukin-12	NNP
cord-265900-7lj4bfli	64	17	,	,	,
cord-265900-7lj4bfli	64	18	PTPRJ	PTPRJ	NNP
cord-265900-7lj4bfli	64	19	(	(	-LRB-
cord-265900-7lj4bfli	64	20	protein	protein	NN
cord-265900-7lj4bfli	64	21	tyrosine	tyrosine	NN
cord-265900-7lj4bfli	64	22	phosphatase	phosphatase	NN
cord-265900-7lj4bfli	64	23	,	,	,
cord-265900-7lj4bfli	64	24	receptor	receptor	NN
cord-265900-7lj4bfli	64	25	type	type	NN
cord-265900-7lj4bfli	64	26	,	,	,
cord-265900-7lj4bfli	64	27	J	J	NNP
cord-265900-7lj4bfli	64	28	)	)	-RRB-
cord-265900-7lj4bfli	64	29	,	,	,
cord-265900-7lj4bfli	64	30	and	and	CC
cord-265900-7lj4bfli	64	31	thrombomodulin	thrombomodulin	NNP
cord-265900-7lj4bfli	64	32	)	)	-RRB-
cord-265900-7lj4bfli	64	33	for	for	IN
cord-265900-7lj4bfli	64	34	US2	US2	NNP
cord-265900-7lj4bfli	64	35	protein	protein	NN
cord-265900-7lj4bfli	64	36	,	,	,
cord-265900-7lj4bfli	64	37	which	which	WDT
cord-265900-7lj4bfli	64	38	are	be	VBP
cord-265900-7lj4bfli	64	39	ubiquitinated	ubiquitinate	VBN
cord-265900-7lj4bfli	64	40	and	and	CC
cord-265900-7lj4bfli	64	41	degraded	degrade	VBN
cord-265900-7lj4bfli	64	42	through	through	IN
cord-265900-7lj4bfli	64	43	the	the	DT
cord-265900-7lj4bfli	64	44	recruitment	recruitment	NN
cord-265900-7lj4bfli	64	45	of	of	IN
cord-265900-7lj4bfli	64	46	the	the	DT
cord-265900-7lj4bfli	64	47	cellular	cellular	JJ
cord-265900-7lj4bfli	64	48	E3	e3	NN
cord-265900-7lj4bfli	64	49	ligase	ligase	NN
cord-265900-7lj4bfli	64	50	(	(	-LRB-
cord-265900-7lj4bfli	64	51	TRC8	TRC8	NNP
cord-265900-7lj4bfli	64	52	)	)	-RRB-
cord-265900-7lj4bfli	64	53	[	[	-LRB-
cord-265900-7lj4bfli	64	54	24	24	CD
cord-265900-7lj4bfli	64	55	]	]	-RRB-
cord-265900-7lj4bfli	64	56	.	.	.
cord-265900-7lj4bfli	65	1	Together	together	RB
cord-265900-7lj4bfli	65	2	,	,	,
cord-265900-7lj4bfli	65	3	these	these	DT
cord-265900-7lj4bfli	65	4	studies	study	NNS
cord-265900-7lj4bfli	65	5	suggest	suggest	VBP
cord-265900-7lj4bfli	65	6	that	that	IN
cord-265900-7lj4bfli	65	7	US2	US2	NNP
cord-265900-7lj4bfli	65	8	acts	act	VBZ
cord-265900-7lj4bfli	65	9	as	as	IN
cord-265900-7lj4bfli	65	10	a	a	DT
cord-265900-7lj4bfli	65	11	degradation	degradation	NN
cord-265900-7lj4bfli	65	12	hub	hub	NN
cord-265900-7lj4bfli	65	13	modulating	modulate	VBG
cord-265900-7lj4bfli	65	14	multiple	multiple	JJ
cord-265900-7lj4bfli	65	15	host	host	NN
cord-265900-7lj4bfli	65	16	immune	immune	JJ
cord-265900-7lj4bfli	65	17	responses	response	NNS
cord-265900-7lj4bfli	65	18	to	to	IN
cord-265900-7lj4bfli	65	19	HCMV	HCMV	NNP
cord-265900-7lj4bfli	65	20	infection	infection	NN
cord-265900-7lj4bfli	65	21	.	.	.
cord-265900-7lj4bfli	66	1	In	in	IN
cord-265900-7lj4bfli	66	2	addition	addition	NN
cord-265900-7lj4bfli	66	3	to	to	IN
cord-265900-7lj4bfli	66	4	MHC	MHC	NNP
cord-265900-7lj4bfli	66	5	class	class	NN
cord-265900-7lj4bfli	66	6	I	i	NN
cord-265900-7lj4bfli	66	7	,	,	,
cord-265900-7lj4bfli	66	8	the	the	DT
cord-265900-7lj4bfli	66	9	Janus	Janus	NNP
cord-265900-7lj4bfli	66	10	kinase	kinase	NN
cord-265900-7lj4bfli	66	11	-	-	HYPH
cord-265900-7lj4bfli	66	12	signal	signal	NN
cord-265900-7lj4bfli	66	13	transducers	transducer	NNS
cord-265900-7lj4bfli	66	14	and	and	CC
cord-265900-7lj4bfli	66	15	activators	activator	NNS
cord-265900-7lj4bfli	66	16	of	of	IN
cord-265900-7lj4bfli	66	17	transcription	transcription	NN
cord-265900-7lj4bfli	66	18	(	(	-LRB-
cord-265900-7lj4bfli	66	19	JAK	JAK	NNP
cord-265900-7lj4bfli	66	20	/	/	SYM
cord-265900-7lj4bfli	66	21	STAT	STAT	NNP
cord-265900-7lj4bfli	66	22	)	)	-RRB-
cord-265900-7lj4bfli	66	23	and	and	CC
cord-265900-7lj4bfli	66	24	NFkB	NFkB	NNP
cord-265900-7lj4bfli	66	25	pathways	pathway	NNS
cord-265900-7lj4bfli	66	26	also	also	RB
cord-265900-7lj4bfli	66	27	play	play	VBP
cord-265900-7lj4bfli	66	28	critical	critical	JJ
cord-265900-7lj4bfli	66	29	roles	role	NNS
cord-265900-7lj4bfli	66	30	in	in	IN
cord-265900-7lj4bfli	66	31	host	host	JJ
cord-265900-7lj4bfli	66	32	anti	anti	JJ
cord-265900-7lj4bfli	66	33	-	-	JJ
cord-265900-7lj4bfli	66	34	viral	viral	JJ
cord-265900-7lj4bfli	66	35	defense	defense	NN
cord-265900-7lj4bfli	66	36	.	.	.
cord-265900-7lj4bfli	67	1	Viruses	virus	NNS
cord-265900-7lj4bfli	67	2	have	have	VBP
cord-265900-7lj4bfli	67	3	developed	develop	VBN
cord-265900-7lj4bfli	67	4	distinct	distinct	JJ
cord-265900-7lj4bfli	67	5	mechanisms	mechanism	NNS
cord-265900-7lj4bfli	67	6	to	to	TO
cord-265900-7lj4bfli	67	7	utilize	utilize	VB
cord-265900-7lj4bfli	67	8	the	the	DT
cord-265900-7lj4bfli	67	9	UPS	up	NNS
cord-265900-7lj4bfli	67	10	to	to	TO
cord-265900-7lj4bfli	67	11	dampen	dampen	VB
cord-265900-7lj4bfli	67	12	these	these	DT
cord-265900-7lj4bfli	67	13	host	host	NN
cord-265900-7lj4bfli	67	14	innate	innate	JJ
cord-265900-7lj4bfli	67	15	immune	immune	JJ
cord-265900-7lj4bfli	67	16	responses	response	NNS
cord-265900-7lj4bfli	67	17	.	.	.
cord-265900-7lj4bfli	68	1	One	one	CD
cord-265900-7lj4bfli	68	2	such	such	JJ
cord-265900-7lj4bfli	68	3	example	example	NN
cord-265900-7lj4bfli	68	4	is	be	VBZ
cord-265900-7lj4bfli	68	5	the	the	DT
cord-265900-7lj4bfli	68	6	V	V	NNP
cord-265900-7lj4bfli	68	7	protein	protein	NN
cord-265900-7lj4bfli	68	8	of	of	IN
cord-265900-7lj4bfli	68	9	paramyxoviruses	paramyxovirus	NNS
cord-265900-7lj4bfli	68	10	,	,	,
cord-265900-7lj4bfli	68	11	including	include	VBG
cord-265900-7lj4bfli	68	12	mumps	mumps	NN
cord-265900-7lj4bfli	68	13	virus	virus	NN
cord-265900-7lj4bfli	68	14	,	,	,
cord-265900-7lj4bfli	68	15	simian	simian	JJ
cord-265900-7lj4bfli	68	16	virus	virus	NN
cord-265900-7lj4bfli	68	17	5	5	CD
cord-265900-7lj4bfli	68	18	,	,	,
cord-265900-7lj4bfli	68	19	and	and	CC
cord-265900-7lj4bfli	68	20	parainfluenza	parainfluenza	NNP
cord-265900-7lj4bfli	68	21	virus	virus	NNP
cord-265900-7lj4bfli	68	22	type	type	NNP
cord-265900-7lj4bfli	68	23	2	2	CD
cord-265900-7lj4bfli	68	24	,	,	,
cord-265900-7lj4bfli	68	25	which	which	WDT
cord-265900-7lj4bfli	68	26	promotes	promote	VBZ
cord-265900-7lj4bfli	68	27	UPS	UPS	NNP
cord-265900-7lj4bfli	68	28	-	-	HYPH
cord-265900-7lj4bfli	68	29	dependent	dependent	JJ
cord-265900-7lj4bfli	68	30	STAT	stat	NN
cord-265900-7lj4bfli	68	31	degradation	degradation	NN
cord-265900-7lj4bfli	68	32	through	through	IN
cord-265900-7lj4bfli	68	33	co	co	NN
cord-265900-7lj4bfli	68	34	-	-	JJ
cord-265900-7lj4bfli	68	35	opting	opting	JJ
cord-265900-7lj4bfli	69	1	a	a	DT
cord-265900-7lj4bfli	69	2	host	host	NN
cord-265900-7lj4bfli	69	3	cellular	cellular	JJ
cord-265900-7lj4bfli	69	4	E3	e3	NN
cord-265900-7lj4bfli	69	5	ligase	ligase	NN
cord-265900-7lj4bfli	69	6	[	[	-LRB-
cord-265900-7lj4bfli	69	7	25	25	CD
cord-265900-7lj4bfli	69	8	]	]	-RRB-
cord-265900-7lj4bfli	69	9	[	[	-LRB-
cord-265900-7lj4bfli	69	10	26	26	CD
cord-265900-7lj4bfli	69	11	]	]	-RRB-
cord-265900-7lj4bfli	69	12	[	[	-LRB-
cord-265900-7lj4bfli	69	13	27	27	CD
cord-265900-7lj4bfli	69	14	]	]	-RRB-
cord-265900-7lj4bfli	69	15	.	.	.
cord-265900-7lj4bfli	70	1	Similarly	similarly	RB
cord-265900-7lj4bfli	70	2	,	,	,
cord-265900-7lj4bfli	70	3	the	the	DT
cord-265900-7lj4bfli	70	4	dengue	dengue	NN
cord-265900-7lj4bfli	70	5	virus	virus	NN
cord-265900-7lj4bfli	70	6	NS5	ns5	JJ
cord-265900-7lj4bfli	70	7	protein	protein	NN
cord-265900-7lj4bfli	70	8	was	be	VBD
cord-265900-7lj4bfli	70	9	also	also	RB
cord-265900-7lj4bfli	70	10	found	find	VBN
cord-265900-7lj4bfli	70	11	to	to	TO
cord-265900-7lj4bfli	70	12	stimulate	stimulate	VB
cord-265900-7lj4bfli	70	13	proteasomal	proteasomal	JJ
cord-265900-7lj4bfli	70	14	degradation	degradation	NN
cord-265900-7lj4bfli	70	15	of	of	IN
cord-265900-7lj4bfli	70	16	STAT2	STAT2	NNS
cord-265900-7lj4bfli	70	17	,	,	,
cord-265900-7lj4bfli	70	18	thus	thus	RB
cord-265900-7lj4bfli	70	19	blocking	block	VBG
cord-265900-7lj4bfli	70	20	type	type	NN
cord-265900-7lj4bfli	71	1	I	-PRON-	PRP
cord-265900-7lj4bfli	71	2	IFN	IFN	NNP
cord-265900-7lj4bfli	71	3	signaling	signal	VBG
cord-265900-7lj4bfli	71	4	[	[	-LRB-
cord-265900-7lj4bfli	71	5	28	28	CD
cord-265900-7lj4bfli	71	6	]	]	-RRB-
cord-265900-7lj4bfli	71	7	.	.	.
cord-265900-7lj4bfli	72	1	Moreover	moreover	RB
cord-265900-7lj4bfli	72	2	,	,	,
cord-265900-7lj4bfli	72	3	it	-PRON-	PRP
cord-265900-7lj4bfli	72	4	was	be	VBD
cord-265900-7lj4bfli	72	5	recently	recently	RB
cord-265900-7lj4bfli	72	6	reported	report	VBN
cord-265900-7lj4bfli	72	7	that	that	IN
cord-265900-7lj4bfli	72	8	the	the	DT
cord-265900-7lj4bfli	72	9	ORF61	ORF61	NNP
cord-265900-7lj4bfli	72	10	protein	protein	NN
cord-265900-7lj4bfli	72	11	encoded	encode	VBN
cord-265900-7lj4bfli	72	12	by	by	IN
cord-265900-7lj4bfli	72	13	simian	simian	JJ
cord-265900-7lj4bfli	72	14	varicella	varicella	NN
cord-265900-7lj4bfli	72	15	virus	virus	NN
cord-265900-7lj4bfli	72	16	and	and	CC
cord-265900-7lj4bfli	72	17	varicella	varicella	NN
cord-265900-7lj4bfli	72	18	zoster	zoster	NNP
cord-265900-7lj4bfli	72	19	virus	virus	NN
cord-265900-7lj4bfli	72	20	prevents	prevent	VBZ
cord-265900-7lj4bfli	72	21	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	72	22	and	and	CC
cord-265900-7lj4bfli	72	23	degradation	degradation	NN
cord-265900-7lj4bfli	72	24	of	of	IN
cord-265900-7lj4bfli	72	25	IkBa	IkBa	NNP
cord-265900-7lj4bfli	72	26	,	,	,
cord-265900-7lj4bfli	72	27	most	most	RBS
cord-265900-7lj4bfli	72	28	likely	likely	RB
cord-265900-7lj4bfli	72	29	through	through	IN
cord-265900-7lj4bfli	72	30	interacting	interact	VBG
cord-265900-7lj4bfli	72	31	with	with	IN
cord-265900-7lj4bfli	72	32	b	b	NN
cord-265900-7lj4bfli	72	33	-	-	HYPH
cord-265900-7lj4bfli	72	34	transducin	transducin	NN
cord-265900-7lj4bfli	72	35	repeat	repeat	NN
cord-265900-7lj4bfli	72	36	containing	contain	VBG
cord-265900-7lj4bfli	72	37	protein	protein	NN
cord-265900-7lj4bfli	72	38	,	,	,
cord-265900-7lj4bfli	72	39	a	a	DT
cord-265900-7lj4bfli	72	40	subunit	subunit	NN
cord-265900-7lj4bfli	72	41	of	of	IN
cord-265900-7lj4bfli	72	42	the	the	DT
cord-265900-7lj4bfli	72	43	Skp1-Cul1-F	Skp1-Cul1-F	NNP
cord-265900-7lj4bfli	72	44	-	-	HYPH
cord-265900-7lj4bfli	72	45	box	box	NN
cord-265900-7lj4bfli	72	46	(	(	-LRB-
cord-265900-7lj4bfli	72	47	SCF	SCF	NNP
cord-265900-7lj4bfli	72	48	)	)	-RRB-
cord-265900-7lj4bfli	72	49	E3	E3	NNP
cord-265900-7lj4bfli	72	50	complex	complex	NN
cord-265900-7lj4bfli	72	51	,	,	,
cord-265900-7lj4bfli	72	52	thereby	thereby	RB
cord-265900-7lj4bfli	72	53	suppressing	suppress	VBG
cord-265900-7lj4bfli	72	54	NFkB	nfkb	VB
cord-265900-7lj4bfli	72	55	-	-	HYPH
cord-265900-7lj4bfli	72	56	mediated	mediate	VBN
cord-265900-7lj4bfli	72	57	immune	immune	JJ
cord-265900-7lj4bfli	72	58	responses	response	NNS
cord-265900-7lj4bfli	72	59	[	[	-LRB-
cord-265900-7lj4bfli	72	60	29	29	CD
cord-265900-7lj4bfli	72	61	]	]	-RRB-
cord-265900-7lj4bfli	72	62	.	.	.
cord-265900-7lj4bfli	73	1	RNA	RNA	NNP
cord-265900-7lj4bfli	73	2	silencing	silencing	NN
cord-265900-7lj4bfli	73	3	is	be	VBZ
cord-265900-7lj4bfli	73	4	an	an	DT
cord-265900-7lj4bfli	73	5	important	important	JJ
cord-265900-7lj4bfli	73	6	host	host	NN
cord-265900-7lj4bfli	73	7	defense	defense	NN
cord-265900-7lj4bfli	73	8	mechanism	mechanism	NN
cord-265900-7lj4bfli	73	9	against	against	IN
cord-265900-7lj4bfli	73	10	viral	viral	JJ
cord-265900-7lj4bfli	73	11	infection	infection	NN
cord-265900-7lj4bfli	73	12	in	in	IN
cord-265900-7lj4bfli	73	13	plants	plant	NNS
cord-265900-7lj4bfli	73	14	[	[	-LRB-
cord-265900-7lj4bfli	73	15	30	30	CD
cord-265900-7lj4bfli	73	16	]	]	-RRB-
cord-265900-7lj4bfli	73	17	.	.	.
cord-265900-7lj4bfli	74	1	To	to	TO
cord-265900-7lj4bfli	74	2	combat	combat	VB
cord-265900-7lj4bfli	74	3	this	this	DT
cord-265900-7lj4bfli	74	4	anti	anti	JJ
cord-265900-7lj4bfli	74	5	-	-	JJ
cord-265900-7lj4bfli	74	6	viral	viral	JJ
cord-265900-7lj4bfli	74	7	immunity	immunity	NN
cord-265900-7lj4bfli	74	8	,	,	,
cord-265900-7lj4bfli	74	9	several	several	JJ
cord-265900-7lj4bfli	74	10	plant	plant	NN
cord-265900-7lj4bfli	74	11	viruses	virus	NNS
cord-265900-7lj4bfli	74	12	encode	encode	VBP
cord-265900-7lj4bfli	74	13	proteins	protein	NNS
cord-265900-7lj4bfli	74	14	to	to	TO
cord-265900-7lj4bfli	74	15	target	target	VB
cord-265900-7lj4bfli	74	16	key	key	JJ
cord-265900-7lj4bfli	74	17	components	component	NNS
cord-265900-7lj4bfli	74	18	of	of	IN
cord-265900-7lj4bfli	74	19	RNA	RNA	NNP
cord-265900-7lj4bfli	74	20	silencing	silencing	NN
cord-265900-7lj4bfli	74	21	,	,	,
cord-265900-7lj4bfli	74	22	such	such	JJ
cord-265900-7lj4bfli	74	23	as	as	IN
cord-265900-7lj4bfli	74	24	the	the	DT
cord-265900-7lj4bfli	74	25	ARGONAUTE1	argonaute1	NN
cord-265900-7lj4bfli	74	26	protein	protein	NN
cord-265900-7lj4bfli	74	27	[	[	-LRB-
cord-265900-7lj4bfli	74	28	31,32	31,32	CD
cord-265900-7lj4bfli	74	29	]	]	-RRB-
cord-265900-7lj4bfli	74	30	,	,	,
cord-265900-7lj4bfli	74	31	for	for	IN
cord-265900-7lj4bfli	74	32	proteasomal	proteasomal	JJ
cord-265900-7lj4bfli	74	33	degradation	degradation	NN
cord-265900-7lj4bfli	74	34	.	.	.
cord-265900-7lj4bfli	75	1	Together	together	RB
cord-265900-7lj4bfli	75	2	,	,	,
cord-265900-7lj4bfli	75	3	hijacking	hijack	VBG
cord-265900-7lj4bfli	75	4	the	the	DT
cord-265900-7lj4bfli	75	5	UPS	UPS	NNP
cord-265900-7lj4bfli	75	6	is	be	VBZ
cord-265900-7lj4bfli	75	7	a	a	DT
cord-265900-7lj4bfli	75	8	common	common	JJ
cord-265900-7lj4bfli	75	9	viral	viral	JJ
cord-265900-7lj4bfli	75	10	strategy	strategy	NN
cord-265900-7lj4bfli	75	11	to	to	TO
cord-265900-7lj4bfli	75	12	evade	evade	VB
cord-265900-7lj4bfli	75	13	host	host	NN
cord-265900-7lj4bfli	75	14	immune	immune	JJ
cord-265900-7lj4bfli	75	15	response	response	NN
cord-265900-7lj4bfli	75	16	.	.	.
cord-265900-7lj4bfli	76	1	In	in	IN
cord-265900-7lj4bfli	76	2	addition	addition	NN
cord-265900-7lj4bfli	76	3	to	to	IN
cord-265900-7lj4bfli	76	4	its	-PRON-	PRP$
cord-265900-7lj4bfli	76	5	pro	pro	JJ
cord-265900-7lj4bfli	76	6	-	-	JJ
cord-265900-7lj4bfli	76	7	viral	viral	JJ
cord-265900-7lj4bfli	76	8	function	function	NN
cord-265900-7lj4bfli	76	9	usurped	usurp	VBN
cord-265900-7lj4bfli	76	10	by	by	IN
cord-265900-7lj4bfli	76	11	viruses	virus	NNS
cord-265900-7lj4bfli	76	12	as	as	IN
cord-265900-7lj4bfli	76	13	discussed	discuss	VBN
cord-265900-7lj4bfli	76	14	above	above	RB
cord-265900-7lj4bfli	76	15	,	,	,
cord-265900-7lj4bfli	76	16	the	the	DT
cord-265900-7lj4bfli	76	17	UPS	UPS	NNP
cord-265900-7lj4bfli	76	18	-	-	HYPH
cord-265900-7lj4bfli	76	19	mediated	mediate	VBN
cord-265900-7lj4bfli	76	20	cellular	cellular	JJ
cord-265900-7lj4bfli	76	21	protein	protein	NN
cord-265900-7lj4bfli	76	22	degradation	degradation	NN
cord-265900-7lj4bfli	76	23	may	may	MD
cord-265900-7lj4bfli	76	24	also	also	RB
cord-265900-7lj4bfli	76	25	represent	represent	VB
cord-265900-7lj4bfli	76	26	a	a	DT
cord-265900-7lj4bfli	76	27	host	host	NN
cord-265900-7lj4bfli	76	28	defense	defense	NN
cord-265900-7lj4bfli	76	29	mechanism	mechanism	NN
cord-265900-7lj4bfli	76	30	against	against	IN
cord-265900-7lj4bfli	76	31	viral	viral	JJ
cord-265900-7lj4bfli	76	32	infection	infection	NN
cord-265900-7lj4bfli	76	33	.	.	.
cord-265900-7lj4bfli	77	1	For	for	IN
cord-265900-7lj4bfli	77	2	example	example	NN
cord-265900-7lj4bfli	77	3	,	,	,
cord-265900-7lj4bfli	77	4	the	the	DT
cord-265900-7lj4bfli	77	5	Rar1	Rar1	NNP
cord-265900-7lj4bfli	77	6	protein	protein	NN
cord-265900-7lj4bfli	77	7	,	,	,
cord-265900-7lj4bfli	77	8	a	a	DT
cord-265900-7lj4bfli	77	9	critical	critical	JJ
cord-265900-7lj4bfli	77	10	downstream	downstream	JJ
cord-265900-7lj4bfli	77	11	product	product	NN
cord-265900-7lj4bfli	77	12	of	of	IN
cord-265900-7lj4bfli	77	13	the	the	DT
cord-265900-7lj4bfli	77	14	N	n	CD
cord-265900-7lj4bfli	77	15	gene	gene	NN
cord-265900-7lj4bfli	77	16	of	of	IN
cord-265900-7lj4bfli	77	17	tobacco	tobacco	NN
cord-265900-7lj4bfli	77	18	,	,	,
cord-265900-7lj4bfli	77	19	was	be	VBD
cord-265900-7lj4bfli	77	20	shown	show	VBN
cord-265900-7lj4bfli	77	21	to	to	TO
cord-265900-7lj4bfli	77	22	interact	interact	VB
cord-265900-7lj4bfli	77	23	with	with	IN
cord-265900-7lj4bfli	77	24	SGT1	SGT1	NNP
cord-265900-7lj4bfli	77	25	,	,	,
cord-265900-7lj4bfli	77	26	a	a	DT
cord-265900-7lj4bfli	77	27	highly	highly	RB
cord-265900-7lj4bfli	77	28	conserved	conserved	JJ
cord-265900-7lj4bfli	77	29	component	component	NN
cord-265900-7lj4bfli	77	30	of	of	IN
cord-265900-7lj4bfli	77	31	SCF	SCF	NNP
cord-265900-7lj4bfli	77	32	E3	E3	NNP
cord-265900-7lj4bfli	77	33	complex	complex	NN
cord-265900-7lj4bfli	77	34	,	,	,
cord-265900-7lj4bfli	77	35	and	and	CC
cord-265900-7lj4bfli	77	36	COP9	COP9	NNP
cord-265900-7lj4bfli	77	37	signalosome	signalosome	NN
cord-265900-7lj4bfli	77	38	,	,	,
cord-265900-7lj4bfli	77	39	a	a	DT
cord-265900-7lj4bfli	77	40	multiprotein	multiprotein	NN
cord-265900-7lj4bfli	77	41	complex	complex	NN
cord-265900-7lj4bfli	77	42	involved	involve	VBN
cord-265900-7lj4bfli	77	43	in	in	IN
cord-265900-7lj4bfli	77	44	UPS	UPS	NNP
cord-265900-7lj4bfli	77	45	-	-	HYPH
cord-265900-7lj4bfli	77	46	mediated	mediate	VBN
cord-265900-7lj4bfli	77	47	protein	protein	NN
cord-265900-7lj4bfli	77	48	degradation	degradation	NN
cord-265900-7lj4bfli	77	49	[	[	-LRB-
cord-265900-7lj4bfli	77	50	33	33	CD
cord-265900-7lj4bfli	77	51	]	]	-RRB-
cord-265900-7lj4bfli	77	52	.	.	.
cord-265900-7lj4bfli	78	1	Inhibition	inhibition	NN
cord-265900-7lj4bfli	78	2	of	of	IN
cord-265900-7lj4bfli	78	3	SGT1	SGT1	NNP
cord-265900-7lj4bfli	78	4	and	and	CC
cord-265900-7lj4bfli	78	5	COP9	COP9	NNP
cord-265900-7lj4bfli	78	6	abolishes	abolish	VBZ
cord-265900-7lj4bfli	78	7	the	the	DT
cord-265900-7lj4bfli	78	8	N	n	CD
cord-265900-7lj4bfli	78	9	gene	gene	NN
cord-265900-7lj4bfli	78	10	-	-	HYPH
cord-265900-7lj4bfli	78	11	mediated	mediate	VBN
cord-265900-7lj4bfli	78	12	resistance	resistance	NN
cord-265900-7lj4bfli	78	13	to	to	IN
cord-265900-7lj4bfli	78	14	Tobacco	tobacco	NN
cord-265900-7lj4bfli	78	15	mosaic	mosaic	JJ
cord-265900-7lj4bfli	78	16	virus	virus	NN
cord-265900-7lj4bfli	78	17	,	,	,
cord-265900-7lj4bfli	78	18	suggesting	suggest	VBG
cord-265900-7lj4bfli	78	19	a	a	DT
cord-265900-7lj4bfli	78	20	key	key	JJ
cord-265900-7lj4bfli	78	21	role	role	NN
cord-265900-7lj4bfli	78	22	for	for	IN
cord-265900-7lj4bfli	78	23	the	the	DT
cord-265900-7lj4bfli	78	24	UPS	up	NNS
cord-265900-7lj4bfli	78	25	in	in	IN
cord-265900-7lj4bfli	78	26	the	the	DT
cord-265900-7lj4bfli	78	27	regulation	regulation	NN
cord-265900-7lj4bfli	78	28	of	of	IN
cord-265900-7lj4bfli	78	29	plant	plant	NN
cord-265900-7lj4bfli	78	30	innate	innate	JJ
cord-265900-7lj4bfli	78	31	immune	immune	JJ
cord-265900-7lj4bfli	78	32	response	response	NN
cord-265900-7lj4bfli	78	33	[	[	-LRB-
cord-265900-7lj4bfli	78	34	33	33	CD
cord-265900-7lj4bfli	78	35	,	,	,
cord-265900-7lj4bfli	78	36	34	34	CD
cord-265900-7lj4bfli	78	37	]	]	-RRB-
cord-265900-7lj4bfli	78	38	.	.	.
cord-265900-7lj4bfli	79	1	Further	further	JJ
cord-265900-7lj4bfli	79	2	study	study	NN
cord-265900-7lj4bfli	79	3	revealed	reveal	VBD
cord-265900-7lj4bfli	79	4	that	that	IN
cord-265900-7lj4bfli	79	5	this	this	DT
cord-265900-7lj4bfli	79	6	anti	anti	JJ
cord-265900-7lj4bfli	79	7	-	-	JJ
cord-265900-7lj4bfli	79	8	viral	viral	JJ
cord-265900-7lj4bfli	79	9	effect	effect	NN
cord-265900-7lj4bfli	79	10	can	can	MD
cord-265900-7lj4bfli	79	11	be	be	VB
cord-265900-7lj4bfli	79	12	counteracted	counteract	VBN
cord-265900-7lj4bfli	79	13	by	by	IN
cord-265900-7lj4bfli	79	14	geminivirus	geminivirus	NNP
cord-265900-7lj4bfli	79	15	-	-	HYPH
cord-265900-7lj4bfli	79	16	encoded	encode	VBN
cord-265900-7lj4bfli	79	17	C2	C2	NNP
cord-265900-7lj4bfli	79	18	protein	protein	NN
cord-265900-7lj4bfli	79	19	,	,	,
cord-265900-7lj4bfli	79	20	which	which	WDT
cord-265900-7lj4bfli	79	21	inhibits	inhibit	VBZ
cord-265900-7lj4bfli	79	22	SCF	scf	NN
cord-265900-7lj4bfli	79	23	activity	activity	NN
cord-265900-7lj4bfli	79	24	and	and	CC
cord-265900-7lj4bfli	79	25	interferes	interfere	VBZ
cord-265900-7lj4bfli	79	26	with	with	IN
cord-265900-7lj4bfli	79	27	the	the	DT
cord-265900-7lj4bfli	79	28	function	function	NN
cord-265900-7lj4bfli	79	29	of	of	IN
cord-265900-7lj4bfli	79	30	COP9	COP9	NNP
cord-265900-7lj4bfli	79	31	signalosome	signalosome	NN
cord-265900-7lj4bfli	79	32	[	[	-LRB-
cord-265900-7lj4bfli	79	33	35	35	CD
cord-265900-7lj4bfli	79	34	]	]	-RRB-
cord-265900-7lj4bfli	79	35	.	.	.
cord-265900-7lj4bfli	80	1	The	the	DT
cord-265900-7lj4bfli	80	2	UPS	UPS	NNP
cord-265900-7lj4bfli	80	3	serves	serve	VBZ
cord-265900-7lj4bfli	80	4	as	as	IN
cord-265900-7lj4bfli	80	5	either	either	CC
cord-265900-7lj4bfli	80	6	a	a	DT
cord-265900-7lj4bfli	80	7	pro	pro	JJ
cord-265900-7lj4bfli	80	8	-	-	JJ
cord-265900-7lj4bfli	80	9	viral	viral	JJ
cord-265900-7lj4bfli	80	10	or	or	CC
cord-265900-7lj4bfli	80	11	anti	anti	JJ
cord-265900-7lj4bfli	80	12	-	-	JJ
cord-265900-7lj4bfli	80	13	viral	viral	JJ
cord-265900-7lj4bfli	80	14	mechanism	mechanism	NN
cord-265900-7lj4bfli	80	15	in	in	IN
cord-265900-7lj4bfli	80	16	the	the	DT
cord-265900-7lj4bfli	80	17	context	context	NN
cord-265900-7lj4bfli	80	18	of	of	IN
cord-265900-7lj4bfli	80	19	controlling	control	VBG
cord-265900-7lj4bfli	80	20	the	the	DT
cord-265900-7lj4bfli	80	21	levels	level	NNS
cord-265900-7lj4bfli	80	22	of	of	IN
cord-265900-7lj4bfli	80	23	viral	viral	JJ
cord-265900-7lj4bfli	80	24	proteins	protein	NNS
cord-265900-7lj4bfli	80	25	.	.	.
cord-265900-7lj4bfli	81	1	Proper	proper	JJ
cord-265900-7lj4bfli	81	2	ratio	ratio	NN
cord-265900-7lj4bfli	81	3	of	of	IN
cord-265900-7lj4bfli	81	4	structural	structural	JJ
cord-265900-7lj4bfli	81	5	over	over	IN
cord-265900-7lj4bfli	81	6	non	non	JJ
cord-265900-7lj4bfli	81	7	-	-	JJ
cord-265900-7lj4bfli	81	8	structural	structural	JJ
cord-265900-7lj4bfli	81	9	viral	viral	JJ
cord-265900-7lj4bfli	81	10	proteins	protein	NNS
cord-265900-7lj4bfli	81	11	is	be	VBZ
cord-265900-7lj4bfli	81	12	critical	critical	JJ
cord-265900-7lj4bfli	81	13	for	for	IN
cord-265900-7lj4bfli	81	14	productive	productive	JJ
cord-265900-7lj4bfli	81	15	viral	viral	JJ
cord-265900-7lj4bfli	81	16	infection	infection	NN
cord-265900-7lj4bfli	81	17	[	[	-LRB-
cord-265900-7lj4bfli	81	18	36	36	CD
cord-265900-7lj4bfli	81	19	,	,	,
cord-265900-7lj4bfli	81	20	37	37	CD
cord-265900-7lj4bfli	81	21	]	]	-RRB-
cord-265900-7lj4bfli	81	22	.	.	.
cord-265900-7lj4bfli	82	1	Viruses	virus	NNS
cord-265900-7lj4bfli	82	2	have	have	VBP
cord-265900-7lj4bfli	82	3	employed	employ	VBN
cord-265900-7lj4bfli	82	4	the	the	DT
cord-265900-7lj4bfli	82	5	UPS	up	NNS
cord-265900-7lj4bfli	82	6	to	to	TO
cord-265900-7lj4bfli	82	7	keep	keep	VB
cord-265900-7lj4bfli	82	8	some	some	DT
cord-265900-7lj4bfli	82	9	viral	viral	JJ
cord-265900-7lj4bfli	82	10	proteins	protein	NNS
cord-265900-7lj4bfli	82	11	,	,	,
cord-265900-7lj4bfli	82	12	mostly	mostly	RB
cord-265900-7lj4bfli	82	13	non	non	JJ
cord-265900-7lj4bfli	82	14	-	-	JJ
cord-265900-7lj4bfli	82	15	structural	structural	JJ
cord-265900-7lj4bfli	82	16	proteins	protein	NNS
cord-265900-7lj4bfli	82	17	,	,	,
cord-265900-7lj4bfli	82	18	such	such	JJ
cord-265900-7lj4bfli	82	19	as	as	IN
cord-265900-7lj4bfli	82	20	RdRp	RdRp	NNP
cord-265900-7lj4bfli	82	21	that	that	WDT
cord-265900-7lj4bfli	82	22	has	have	VBZ
cord-265900-7lj4bfli	82	23	been	be	VBN
cord-265900-7lj4bfli	82	24	demonstrated	demonstrate	VBN
cord-265900-7lj4bfli	82	25	to	to	TO
cord-265900-7lj4bfli	82	26	interfere	interfere	VB
cord-265900-7lj4bfli	82	27	with	with	IN
cord-265900-7lj4bfli	82	28	viral	viral	JJ
cord-265900-7lj4bfli	82	29	packaging	packaging	NN
cord-265900-7lj4bfli	82	30	and	and	CC
cord-265900-7lj4bfli	82	31	even	even	RB
cord-265900-7lj4bfli	82	32	become	become	VBP
cord-265900-7lj4bfli	82	33	anti	anti	JJ
cord-265900-7lj4bfli	82	34	-	-	JJ
cord-265900-7lj4bfli	82	35	viral	viral	JJ
cord-265900-7lj4bfli	82	36	at	at	IN
cord-265900-7lj4bfli	82	37	high	high	JJ
cord-265900-7lj4bfli	82	38	amounts	amount	NNS
cord-265900-7lj4bfli	82	39	[	[	-LRB-
cord-265900-7lj4bfli	82	40	37,38	37,38	CD
cord-265900-7lj4bfli	82	41	]	]	-RRB-
cord-265900-7lj4bfli	82	42	,	,	,
cord-265900-7lj4bfli	82	43	at	at	IN
cord-265900-7lj4bfli	82	44	a	a	DT
cord-265900-7lj4bfli	82	45	relatively	relatively	RB
cord-265900-7lj4bfli	82	46	low	low	JJ
cord-265900-7lj4bfli	82	47	level	level	NN
cord-265900-7lj4bfli	82	48	.	.	.
cord-265900-7lj4bfli	83	1	Multiple	multiple	JJ
cord-265900-7lj4bfli	83	2	studies	study	NNS
cord-265900-7lj4bfli	83	3	have	have	VBP
cord-265900-7lj4bfli	83	4	shown	show	VBN
cord-265900-7lj4bfli	83	5	that	that	IN
cord-265900-7lj4bfli	83	6	the	the	DT
cord-265900-7lj4bfli	83	7	abundance	abundance	NN
cord-265900-7lj4bfli	83	8	of	of	IN
cord-265900-7lj4bfli	83	9	RdRp	RdRp	NNP
cord-265900-7lj4bfli	83	10	encoded	encode	VBN
cord-265900-7lj4bfli	83	11	by	by	IN
cord-265900-7lj4bfli	83	12	Turnip	Turnip	NNP
cord-265900-7lj4bfli	83	13	yellow	yellow	JJ
cord-265900-7lj4bfli	83	14	mosaic	mosaic	JJ
cord-265900-7lj4bfli	83	15	virus	virus	NN
cord-265900-7lj4bfli	83	16	[	[	-LRB-
cord-265900-7lj4bfli	83	17	39	39	CD
cord-265900-7lj4bfli	83	18	]	]	-RRB-
cord-265900-7lj4bfli	83	19	,	,	,
cord-265900-7lj4bfli	83	20	Sindbis	Sindbis	NNP
cord-265900-7lj4bfli	83	21	virus	virus	NN
cord-265900-7lj4bfli	83	22	[	[	-LRB-
cord-265900-7lj4bfli	83	23	40	40	CD
cord-265900-7lj4bfli	83	24	]	]	-RRB-
cord-265900-7lj4bfli	83	25	,	,	,
cord-265900-7lj4bfli	83	26	hepatitis	hepatitis	NN
cord-265900-7lj4bfli	83	27	C	C	NNP
cord-265900-7lj4bfli	83	28	virus	virus	NN
cord-265900-7lj4bfli	83	29	(	(	-LRB-
cord-265900-7lj4bfli	83	30	HCV	HCV	NNP
cord-265900-7lj4bfli	83	31	)	)	-RRB-
cord-265900-7lj4bfli	83	32	[	[	-LRB-
cord-265900-7lj4bfli	83	33	41	41	CD
cord-265900-7lj4bfli	83	34	]	]	-RRB-
cord-265900-7lj4bfli	83	35	,	,	,
cord-265900-7lj4bfli	83	36	and	and	CC
cord-265900-7lj4bfli	83	37	hepatitis	hepatitis	NNP
cord-265900-7lj4bfli	83	38	A	a	DT
cord-265900-7lj4bfli	83	39	virus	virus	NN
cord-265900-7lj4bfli	83	40	(	(	-LRB-
cord-265900-7lj4bfli	83	41	HAV	hav	VB
cord-265900-7lj4bfli	83	42	)	)	-RRB-
cord-265900-7lj4bfli	83	43	[	[	-LRB-
cord-265900-7lj4bfli	83	44	42	42	CD
cord-265900-7lj4bfli	83	45	]	]	-RRB-
cord-265900-7lj4bfli	83	46	is	be	VBZ
cord-265900-7lj4bfli	83	47	tightly	tightly	RB
cord-265900-7lj4bfli	83	48	controlled	control	VBN
cord-265900-7lj4bfli	83	49	via	via	IN
cord-265900-7lj4bfli	83	50	the	the	DT
cord-265900-7lj4bfli	83	51	UPS	UPS	NNP
cord-265900-7lj4bfli	83	52	.	.	.
cord-265900-7lj4bfli	84	1	Similarly	similarly	RB
cord-265900-7lj4bfli	84	2	,	,	,
cord-265900-7lj4bfli	84	3	previous	previous	JJ
cord-265900-7lj4bfli	84	4	reports	report	NNS
cord-265900-7lj4bfli	84	5	on	on	IN
cord-265900-7lj4bfli	84	6	picornavirus	picornavirus	NNP
cord-265900-7lj4bfli	84	7	have	have	VBP
cord-265900-7lj4bfli	84	8	revealed	reveal	VBN
cord-265900-7lj4bfli	84	9	that	that	IN
cord-265900-7lj4bfli	84	10	the	the	DT
cord-265900-7lj4bfli	84	11	3C	3C	NNP
cord-265900-7lj4bfli	84	12	protease	protease	NNP
cord-265900-7lj4bfli	84	13	of	of	IN
cord-265900-7lj4bfli	84	14	encephalomyocarditis	encephalomyocarditis	NNP
cord-265900-7lj4bfli	84	15	virus	virus	NN
cord-265900-7lj4bfli	84	16	and	and	CC
cord-265900-7lj4bfli	84	17	HAV	HAV	NNP
cord-265900-7lj4bfli	84	18	is	be	VBZ
cord-265900-7lj4bfli	84	19	rapidly	rapidly	RB
cord-265900-7lj4bfli	84	20	degraded	degrade	VBN
cord-265900-7lj4bfli	84	21	via	via	IN
cord-265900-7lj4bfli	84	22	the	the	DT
cord-265900-7lj4bfli	84	23	UPS	up	NNS
cord-265900-7lj4bfli	84	24	and	and	CC
cord-265900-7lj4bfli	84	25	present	present	JJ
cord-265900-7lj4bfli	84	26	in	in	IN
cord-265900-7lj4bfli	84	27	low	low	JJ
cord-265900-7lj4bfli	84	28	concentrations	concentration	NNS
cord-265900-7lj4bfli	84	29	in	in	IN
cord-265900-7lj4bfli	84	30	infected	infected	JJ
cord-265900-7lj4bfli	84	31	cells	cell	NNS
cord-265900-7lj4bfli	84	32	[	[	-LRB-
cord-265900-7lj4bfli	84	33	43	43	CD
cord-265900-7lj4bfli	84	34	]	]	-RRB-
cord-265900-7lj4bfli	84	35	[	[	-LRB-
cord-265900-7lj4bfli	84	36	44	44	CD
cord-265900-7lj4bfli	84	37	]	]	-RRB-
cord-265900-7lj4bfli	84	38	[	[	-LRB-
cord-265900-7lj4bfli	84	39	45	45	CD
cord-265900-7lj4bfli	84	40	]	]	-RRB-
cord-265900-7lj4bfli	84	41	.	.	.
cord-265900-7lj4bfli	85	1	Furthermore	furthermore	RB
cord-265900-7lj4bfli	85	2	,	,	,
cord-265900-7lj4bfli	85	3	HCV	HCV	NNP
cord-265900-7lj4bfli	85	4	-	-	HYPH
cord-265900-7lj4bfli	85	5	encoded	encode	VBN
cord-265900-7lj4bfli	85	6	proteases	protease	NNS
cord-265900-7lj4bfli	85	7	NS2/3	NS2/3	NNP
cord-265900-7lj4bfli	85	8	,	,	,
cord-265900-7lj4bfli	85	9	were	be	VBD
cord-265900-7lj4bfli	85	10	found	find	VBN
cord-265900-7lj4bfli	85	11	to	to	TO
cord-265900-7lj4bfli	85	12	be	be	VB
cord-265900-7lj4bfli	85	13	degraded	degrade	VBN
cord-265900-7lj4bfli	85	14	following	follow	VBG
cord-265900-7lj4bfli	85	15	viral	viral	JJ
cord-265900-7lj4bfli	85	16	infection	infection	NN
cord-265900-7lj4bfli	85	17	in	in	IN
cord-265900-7lj4bfli	85	18	a	a	DT
cord-265900-7lj4bfli	85	19	phosphorylationdependent	phosphorylationdependent	JJ
cord-265900-7lj4bfli	85	20	manner	manner	NN
cord-265900-7lj4bfli	85	21	mediated	mediate	VBN
cord-265900-7lj4bfli	85	22	by	by	IN
cord-265900-7lj4bfli	85	23	casein	casein	NN
cord-265900-7lj4bfli	85	24	kinase	kinase	NN
cord-265900-7lj4bfli	85	25	2	2	CD
cord-265900-7lj4bfli	85	26	[	[	-LRB-
cord-265900-7lj4bfli	85	27	46	46	CD
cord-265900-7lj4bfli	85	28	]	]	-RRB-
cord-265900-7lj4bfli	85	29	.	.	.
cord-265900-7lj4bfli	86	1	Another	another	DT
cord-265900-7lj4bfli	86	2	example	example	NN
cord-265900-7lj4bfli	86	3	of	of	IN
cord-265900-7lj4bfli	86	4	viral	viral	JJ
cord-265900-7lj4bfli	86	5	non	non	JJ
cord-265900-7lj4bfli	86	6	-	-	JJ
cord-265900-7lj4bfli	86	7	structural	structural	JJ
cord-265900-7lj4bfli	86	8	protein	protein	NN
cord-265900-7lj4bfli	86	9	degradation	degradation	NN
cord-265900-7lj4bfli	86	10	is	be	VBZ
cord-265900-7lj4bfli	86	11	provided	provide	VBN
cord-265900-7lj4bfli	86	12	by	by	IN
cord-265900-7lj4bfli	86	13	the	the	DT
cord-265900-7lj4bfli	86	14	HPV	HPV	NNP
cord-265900-7lj4bfli	86	15	E7	E7	NNP
cord-265900-7lj4bfli	86	16	,	,	,
cord-265900-7lj4bfli	86	17	which	which	WDT
cord-265900-7lj4bfli	86	18	is	be	VBZ
cord-265900-7lj4bfli	86	19	ubiquitinated	ubiquitinate	VBN
cord-265900-7lj4bfli	86	20	and	and	CC
cord-265900-7lj4bfli	86	21	degraded	degrade	VBN
cord-265900-7lj4bfli	86	22	through	through	IN
cord-265900-7lj4bfli	86	23	two	two	CD
cord-265900-7lj4bfli	86	24	independent	independent	JJ
cord-265900-7lj4bfli	86	25	pathways	pathway	NNS
cord-265900-7lj4bfli	86	26	[	[	-LRB-
cord-265900-7lj4bfli	86	27	47	47	CD
cord-265900-7lj4bfli	86	28	,	,	,
cord-265900-7lj4bfli	86	29	48	48	CD
cord-265900-7lj4bfli	86	30	]	]	-RRB-
cord-265900-7lj4bfli	86	31	.	.	.
cord-265900-7lj4bfli	87	1	One	one	PRP
cord-265900-7lj4bfli	87	2	involves	involve	VBZ
cord-265900-7lj4bfli	87	3	the	the	DT
cord-265900-7lj4bfli	87	4	IFN	IFN	NNP
cord-265900-7lj4bfli	87	5	-	-	HYPH
cord-265900-7lj4bfli	87	6	g	g	NN
cord-265900-7lj4bfli	87	7	-	-	HYPH
cord-265900-7lj4bfli	87	8	inducible	inducible	JJ
cord-265900-7lj4bfli	87	9	suppressor	suppressor	NN
cord-265900-7lj4bfli	87	10	of	of	IN
cord-265900-7lj4bfli	87	11	cytokine	cytokine	NN
cord-265900-7lj4bfli	87	12	signaling-1	signaling-1	NNP
cord-265900-7lj4bfli	87	13	(	(	-LRB-
cord-265900-7lj4bfli	87	14	SOCS1	SOCS1	NNP
cord-265900-7lj4bfli	87	15	)	)	-RRB-
cord-265900-7lj4bfli	87	16	,	,	,
cord-265900-7lj4bfli	87	17	a	a	DT
cord-265900-7lj4bfli	87	18	member	member	NN
cord-265900-7lj4bfli	87	19	of	of	IN
cord-265900-7lj4bfli	87	20	the	the	DT
cord-265900-7lj4bfli	87	21	STAT	stat	NN
cord-265900-7lj4bfli	87	22	signaling	signal	VBG
cord-265900-7lj4bfli	87	23	pathway	pathway	NN
cord-265900-7lj4bfli	87	24	,	,	,
cord-265900-7lj4bfli	87	25	and	and	CC
cord-265900-7lj4bfli	87	26	takes	take	VBZ
cord-265900-7lj4bfli	87	27	place	place	NN
cord-265900-7lj4bfli	87	28	in	in	IN
cord-265900-7lj4bfli	87	29	the	the	DT
cord-265900-7lj4bfli	87	30	cytoplasm	cytoplasm	NN
cord-265900-7lj4bfli	87	31	[	[	-LRB-
cord-265900-7lj4bfli	87	32	47	47	CD
cord-265900-7lj4bfli	87	33	]	]	-RRB-
cord-265900-7lj4bfli	87	34	.	.	.
cord-265900-7lj4bfli	88	1	The	the	DT
cord-265900-7lj4bfli	88	2	other	other	JJ
cord-265900-7lj4bfli	88	3	requires	require	VBZ
cord-265900-7lj4bfli	88	4	the	the	DT
cord-265900-7lj4bfli	88	5	SCF	SCF	NNP
cord-265900-7lj4bfli	88	6	E3	E3	NNP
cord-265900-7lj4bfli	88	7	complex	complex	NN
cord-265900-7lj4bfli	88	8	,	,	,
cord-265900-7lj4bfli	88	9	which	which	WDT
cord-265900-7lj4bfli	88	10	induces	induce	VBZ
cord-265900-7lj4bfli	88	11	E7	e7	NN
cord-265900-7lj4bfli	88	12	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	88	13	with	with	IN
cord-265900-7lj4bfli	88	14	the	the	DT
cord-265900-7lj4bfli	88	15	assistance	assistance	NN
cord-265900-7lj4bfli	88	16	of	of	IN
cord-265900-7lj4bfli	88	17	E2	E2	NNP
cord-265900-7lj4bfli	88	18	enzyme	enzyme	NN
cord-265900-7lj4bfli	88	19	UbcH7	UbcH7	NNP
cord-265900-7lj4bfli	88	20	and	and	CC
cord-265900-7lj4bfli	88	21	subsequent	subsequent	JJ
cord-265900-7lj4bfli	88	22	degradation	degradation	NN
cord-265900-7lj4bfli	88	23	in	in	IN
cord-265900-7lj4bfli	88	24	the	the	DT
cord-265900-7lj4bfli	88	25	nucleus	nucleus	NN
cord-265900-7lj4bfli	88	26	[	[	-LRB-
cord-265900-7lj4bfli	88	27	48	48	CD
cord-265900-7lj4bfli	88	28	]	]	-RRB-
cord-265900-7lj4bfli	88	29	.	.	.
cord-265900-7lj4bfli	89	1	In	in	IN
cord-265900-7lj4bfli	89	2	addition	addition	NN
cord-265900-7lj4bfli	89	3	to	to	IN
cord-265900-7lj4bfli	89	4	being	be	VBG
cord-265900-7lj4bfli	89	5	a	a	DT
cord-265900-7lj4bfli	89	6	viral	viral	JJ
cord-265900-7lj4bfli	89	7	strategy	strategy	NN
cord-265900-7lj4bfli	89	8	for	for	IN
cord-265900-7lj4bfli	89	9	its	-PRON-	PRP$
cord-265900-7lj4bfli	89	10	effective	effective	JJ
cord-265900-7lj4bfli	89	11	infection	infection	NN
cord-265900-7lj4bfli	89	12	,	,	,
cord-265900-7lj4bfli	89	13	it	-PRON-	PRP
cord-265900-7lj4bfli	89	14	is	be	VBZ
cord-265900-7lj4bfli	89	15	also	also	RB
cord-265900-7lj4bfli	89	16	conceivable	conceivable	JJ
cord-265900-7lj4bfli	89	17	that	that	IN
cord-265900-7lj4bfli	89	18	maintaining	maintain	VBG
cord-265900-7lj4bfli	89	19	a	a	DT
cord-265900-7lj4bfli	89	20	low	low	JJ
cord-265900-7lj4bfli	89	21	level	level	NN
cord-265900-7lj4bfli	89	22	of	of	IN
cord-265900-7lj4bfli	89	23	viral	viral	JJ
cord-265900-7lj4bfli	89	24	proteins	protein	NNS
cord-265900-7lj4bfli	89	25	represents	represent	VBZ
cord-265900-7lj4bfli	89	26	a	a	DT
cord-265900-7lj4bfli	89	27	viral	viral	JJ
cord-265900-7lj4bfli	89	28	mechanism	mechanism	NN
cord-265900-7lj4bfli	89	29	to	to	TO
cord-265900-7lj4bfli	89	30	evade	evade	VB
cord-265900-7lj4bfli	89	31	recognition	recognition	NN
cord-265900-7lj4bfli	89	32	by	by	IN
cord-265900-7lj4bfli	89	33	the	the	DT
cord-265900-7lj4bfli	89	34	host	host	NN
cord-265900-7lj4bfli	89	35	immune	immune	JJ
cord-265900-7lj4bfli	89	36	system	system	NN
cord-265900-7lj4bfli	89	37	.	.	.
cord-265900-7lj4bfli	90	1	Alternatively	alternatively	RB
cord-265900-7lj4bfli	90	2	,	,	,
cord-265900-7lj4bfli	90	3	degradation	degradation	NN
cord-265900-7lj4bfli	90	4	of	of	IN
cord-265900-7lj4bfli	90	5	viral	viral	JJ
cord-265900-7lj4bfli	90	6	proteins	protein	NNS
cord-265900-7lj4bfli	90	7	constitutes	constitute	VBZ
cord-265900-7lj4bfli	90	8	a	a	DT
cord-265900-7lj4bfli	90	9	host	host	NN
cord-265900-7lj4bfli	90	10	defense	defense	NN
cord-265900-7lj4bfli	90	11	mechanism	mechanism	NN
cord-265900-7lj4bfli	90	12	.	.	.
cord-265900-7lj4bfli	91	1	In	in	IN
cord-265900-7lj4bfli	91	2	the	the	DT
cord-265900-7lj4bfli	91	3	latter	latter	JJ
cord-265900-7lj4bfli	91	4	case	case	NN
cord-265900-7lj4bfli	91	5	,	,	,
cord-265900-7lj4bfli	91	6	some	some	DT
cord-265900-7lj4bfli	91	7	viral	viral	JJ
cord-265900-7lj4bfli	91	8	structural	structural	JJ
cord-265900-7lj4bfli	91	9	proteins	protein	NNS
cord-265900-7lj4bfli	91	10	are	be	VBP
cord-265900-7lj4bfli	91	11	demonstrated	demonstrate	VBN
cord-265900-7lj4bfli	91	12	to	to	TO
cord-265900-7lj4bfli	91	13	be	be	VB
cord-265900-7lj4bfli	91	14	the	the	DT
cord-265900-7lj4bfli	91	15	targets	target	NNS
cord-265900-7lj4bfli	91	16	of	of	IN
cord-265900-7lj4bfli	91	17	the	the	DT
cord-265900-7lj4bfli	91	18	UPS	UPS	NNPS
cord-265900-7lj4bfli	91	19	.	.	.
cord-265900-7lj4bfli	92	1	For	for	IN
cord-265900-7lj4bfli	92	2	example	example	NN
cord-265900-7lj4bfli	92	3	,	,	,
cord-265900-7lj4bfli	92	4	West	West	NNP
cord-265900-7lj4bfli	92	5	Nile	Nile	NNP
cord-265900-7lj4bfli	92	6	virus	virus	NN
cord-265900-7lj4bfli	92	7	capsid	capsid	NN
cord-265900-7lj4bfli	92	8	protein	protein	NN
cord-265900-7lj4bfli	92	9	is	be	VBZ
cord-265900-7lj4bfli	92	10	ubiquitinated	ubiquitinate	VBN
cord-265900-7lj4bfli	92	11	by	by	IN
cord-265900-7lj4bfli	92	12	the	the	DT
cord-265900-7lj4bfli	92	13	cellular	cellular	JJ
cord-265900-7lj4bfli	92	14	E3	e3	NN
cord-265900-7lj4bfli	92	15	ligase	ligase	NN
cord-265900-7lj4bfli	92	16	,	,	,
cord-265900-7lj4bfli	92	17	Makorin	Makorin	NNP
cord-265900-7lj4bfli	92	18	ring	ring	VBP
cord-265900-7lj4bfli	92	19	finger	finger	NN
cord-265900-7lj4bfli	92	20	protein	protein	NN
cord-265900-7lj4bfli	92	21	1	1	CD
cord-265900-7lj4bfli	92	22	,	,	,
cord-265900-7lj4bfli	92	23	followed	follow	VBN
cord-265900-7lj4bfli	92	24	by	by	IN
cord-265900-7lj4bfli	92	25	proteasomal	proteasomal	JJ
cord-265900-7lj4bfli	92	26	degradation	degradation	NN
cord-265900-7lj4bfli	92	27	[	[	-LRB-
cord-265900-7lj4bfli	92	28	49	49	CD
cord-265900-7lj4bfli	92	29	]	]	-RRB-
cord-265900-7lj4bfli	92	30	.	.	.
cord-265900-7lj4bfli	93	1	It	-PRON-	PRP
cord-265900-7lj4bfli	93	2	was	be	VBD
cord-265900-7lj4bfli	93	3	also	also	RB
cord-265900-7lj4bfli	93	4	shown	show	VBN
cord-265900-7lj4bfli	93	5	that	that	IN
cord-265900-7lj4bfli	93	6	the	the	DT
cord-265900-7lj4bfli	93	7	core	core	NN
cord-265900-7lj4bfli	93	8	protein	protein	NN
cord-265900-7lj4bfli	93	9	of	of	IN
cord-265900-7lj4bfli	93	10	HCV	HCV	NNP
cord-265900-7lj4bfli	93	11	is	be	VBZ
cord-265900-7lj4bfli	93	12	degraded	degrade	VBN
cord-265900-7lj4bfli	93	13	via	via	IN
cord-265900-7lj4bfli	93	14	proteasome	proteasome	NN
cord-265900-7lj4bfli	93	15	in	in	IN
cord-265900-7lj4bfli	93	16	both	both	DT
cord-265900-7lj4bfli	93	17	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	93	18	-	-	HYPH
cord-265900-7lj4bfli	93	19	dependent	dependent	JJ
cord-265900-7lj4bfli	93	20	through	through	IN
cord-265900-7lj4bfli	93	21	recruiting	recruit	VBG
cord-265900-7lj4bfli	93	22	E3	e3	NN
cord-265900-7lj4bfli	93	23	ligase	ligase	NN
cord-265900-7lj4bfli	93	24	E6AP	e6ap	NN
cord-265900-7lj4bfli	93	25	and	and	CC
cord-265900-7lj4bfli	93	26	-independent	-independent	JJ
cord-265900-7lj4bfli	93	27	manner	manner	NN
cord-265900-7lj4bfli	93	28	mediated	mediate	VBN
cord-265900-7lj4bfli	93	29	by	by	IN
cord-265900-7lj4bfli	93	30	proteasome	proteasome	VBN
cord-265900-7lj4bfli	93	31	activator	activator	NN
cord-265900-7lj4bfli	93	32	PA28	PA28	NNP
cord-265900-7lj4bfli	93	33	g	g	NNP
cord-265900-7lj4bfli	93	34	[	[	-LRB-
cord-265900-7lj4bfli	93	35	50	50	CD
cord-265900-7lj4bfli	93	36	]	]	-RRB-
cord-265900-7lj4bfli	93	37	.	.	.
cord-265900-7lj4bfli	94	1	The	the	DT
cord-265900-7lj4bfli	94	2	movement	movement	NN
cord-265900-7lj4bfli	94	3	proteins	protein	NNS
cord-265900-7lj4bfli	94	4	of	of	IN
cord-265900-7lj4bfli	94	5	several	several	JJ
cord-265900-7lj4bfli	94	6	plant	plant	NN
cord-265900-7lj4bfli	94	7	viruses	virus	NNS
cord-265900-7lj4bfli	94	8	are	be	VBP
cord-265900-7lj4bfli	94	9	also	also	RB
cord-265900-7lj4bfli	94	10	degraded	degrade	VBN
cord-265900-7lj4bfli	94	11	through	through	IN
cord-265900-7lj4bfli	94	12	the	the	DT
cord-265900-7lj4bfli	94	13	UPS	UPS	NNP
cord-265900-7lj4bfli	94	14	[	[	-LRB-
cord-265900-7lj4bfli	94	15	51	51	CD
cord-265900-7lj4bfli	94	16	,	,	,
cord-265900-7lj4bfli	94	17	52	52	CD
cord-265900-7lj4bfli	94	18	]	]	-RRB-
cord-265900-7lj4bfli	94	19	.	.	.
cord-265900-7lj4bfli	95	1	Moreover	moreover	RB
cord-265900-7lj4bfli	95	2	,	,	,
cord-265900-7lj4bfli	95	3	it	-PRON-	PRP
cord-265900-7lj4bfli	95	4	was	be	VBD
cord-265900-7lj4bfli	95	5	found	find	VBN
cord-265900-7lj4bfli	95	6	that	that	IN
cord-265900-7lj4bfli	95	7	the	the	DT
cord-265900-7lj4bfli	95	8	host	host	NN
cord-265900-7lj4bfli	95	9	protein	protein	NN
cord-265900-7lj4bfli	95	10	Rsp5p	rsp5p	NN
cord-265900-7lj4bfli	95	11	,	,	,
cord-265900-7lj4bfli	95	12	a	a	DT
cord-265900-7lj4bfli	95	13	member	member	NN
cord-265900-7lj4bfli	95	14	of	of	IN
cord-265900-7lj4bfli	95	15	the	the	DT
cord-265900-7lj4bfli	95	16	Nedd4	nedd4	JJ
cord-265900-7lj4bfli	95	17	(	(	-LRB-
cord-265900-7lj4bfli	95	18	neuronal	neuronal	JJ
cord-265900-7lj4bfli	95	19	precursor	precursor	NN
cord-265900-7lj4bfli	95	20	cell	cell	NN
cord-265900-7lj4bfli	95	21	-	-	:
cord-265900-7lj4bfli	95	22	expressed	express	VBN
cord-265900-7lj4bfli	95	23	developmentally	developmentally	RB
cord-265900-7lj4bfli	95	24	downregulated	downregulated	JJ
cord-265900-7lj4bfli	95	25	4	4	CD
cord-265900-7lj4bfli	95	26	)	)	-RRB-
cord-265900-7lj4bfli	95	27	family	family	NN
cord-265900-7lj4bfli	95	28	of	of	IN
cord-265900-7lj4bfli	95	29	E3	E3	NNP
cord-265900-7lj4bfli	95	30	ligases	ligase	NNS
cord-265900-7lj4bfli	95	31	,	,	,
cord-265900-7lj4bfli	95	32	binds	bind	VBZ
cord-265900-7lj4bfli	95	33	to	to	IN
cord-265900-7lj4bfli	95	34	the	the	DT
cord-265900-7lj4bfli	95	35	p92	p92	NN
cord-265900-7lj4bfli	95	36	replication	replication	NN
cord-265900-7lj4bfli	95	37	protein	protein	NN
cord-265900-7lj4bfli	95	38	of	of	IN
cord-265900-7lj4bfli	95	39	Tomato	Tomato	NNP
cord-265900-7lj4bfli	95	40	bushy	bushy	JJ
cord-265900-7lj4bfli	95	41	stunt	stunt	NN
cord-265900-7lj4bfli	95	42	virus	virus	NN
cord-265900-7lj4bfli	95	43	and	and	CC
cord-265900-7lj4bfli	95	44	promotes	promote	VBZ
cord-265900-7lj4bfli	95	45	its	-PRON-	PRP$
cord-265900-7lj4bfli	95	46	degradation	degradation	NN
cord-265900-7lj4bfli	95	47	and	and	CC
cord-265900-7lj4bfli	95	48	consequent	consequent	JJ
cord-265900-7lj4bfli	95	49	inhibition	inhibition	NN
cord-265900-7lj4bfli	95	50	of	of	IN
cord-265900-7lj4bfli	95	51	viral	viral	JJ
cord-265900-7lj4bfli	95	52	replication	replication	NN
cord-265900-7lj4bfli	95	53	[	[	-LRB-
cord-265900-7lj4bfli	95	54	53	53	CD
cord-265900-7lj4bfli	95	55	]	]	-RRB-
cord-265900-7lj4bfli	95	56	.	.	.
cord-265900-7lj4bfli	96	1	Thus	thus	RB
cord-265900-7lj4bfli	96	2	,	,	,
cord-265900-7lj4bfli	96	3	degradation	degradation	NN
cord-265900-7lj4bfli	96	4	of	of	IN
cord-265900-7lj4bfli	96	5	some	some	DT
cord-265900-7lj4bfli	96	6	viral	viral	JJ
cord-265900-7lj4bfli	96	7	proteins	protein	NNS
cord-265900-7lj4bfli	96	8	can	can	MD
cord-265900-7lj4bfli	96	9	also	also	RB
cord-265900-7lj4bfli	96	10	be	be	VB
cord-265900-7lj4bfli	96	11	a	a	DT
cord-265900-7lj4bfli	96	12	host	host	NN
cord-265900-7lj4bfli	96	13	anti	anti	JJ
cord-265900-7lj4bfli	96	14	-	-	JJ
cord-265900-7lj4bfli	96	15	viral	viral	JJ
cord-265900-7lj4bfli	96	16	defense	defense	NN
cord-265900-7lj4bfli	96	17	mechanism	mechanism	NN
cord-265900-7lj4bfli	96	18	.	.	.
cord-265900-7lj4bfli	97	1	Post	post	JJ
cord-265900-7lj4bfli	97	2	-	-	JJ
cord-265900-7lj4bfli	97	3	translational	translational	JJ
cord-265900-7lj4bfli	97	4	modification	modification	NN
cord-265900-7lj4bfli	97	5	of	of	IN
cord-265900-7lj4bfli	97	6	protein	protein	NN
cord-265900-7lj4bfli	97	7	with	with	IN
cord-265900-7lj4bfli	97	8	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	97	9	and	and	CC
cord-265900-7lj4bfli	97	10	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	97	11	-	-	HYPH
cord-265900-7lj4bfli	97	12	like	like	JJ
cord-265900-7lj4bfli	97	13	proteins	protein	NNS
cord-265900-7lj4bfli	97	14	constitutes	constitute	VBZ
cord-265900-7lj4bfli	97	15	an	an	DT
cord-265900-7lj4bfli	97	16	important	important	JJ
cord-265900-7lj4bfli	97	17	mechanism	mechanism	NN
cord-265900-7lj4bfli	97	18	to	to	TO
cord-265900-7lj4bfli	97	19	regulate	regulate	VB
cord-265900-7lj4bfli	97	20	viral	viral	JJ
cord-265900-7lj4bfli	97	21	protein	protein	NN
cord-265900-7lj4bfli	97	22	function	function	NN
cord-265900-7lj4bfli	97	23	.	.	.
cord-265900-7lj4bfli	98	1	Studies	study	NNS
cord-265900-7lj4bfli	98	2	from	from	IN
cord-265900-7lj4bfli	98	3	different	different	JJ
cord-265900-7lj4bfli	98	4	groups	group	NNS
cord-265900-7lj4bfli	98	5	have	have	VBP
cord-265900-7lj4bfli	98	6	shown	show	VBN
cord-265900-7lj4bfli	98	7	that	that	IN
cord-265900-7lj4bfli	98	8	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	98	9	of	of	IN
cord-265900-7lj4bfli	98	10	the	the	DT
cord-265900-7lj4bfli	98	11	Gag	Gag	NNP
cord-265900-7lj4bfli	98	12	protein	protein	NN
cord-265900-7lj4bfli	98	13	of	of	IN
cord-265900-7lj4bfli	98	14	retroviruses	retrovirus	NNS
cord-265900-7lj4bfli	98	15	is	be	VBZ
cord-265900-7lj4bfli	98	16	required	require	VBN
cord-265900-7lj4bfli	98	17	for	for	IN
cord-265900-7lj4bfli	98	18	its	-PRON-	PRP$
cord-265900-7lj4bfli	98	19	function	function	NN
cord-265900-7lj4bfli	98	20	in	in	IN
cord-265900-7lj4bfli	98	21	viral	viral	JJ
cord-265900-7lj4bfli	98	22	budding	budding	NN
cord-265900-7lj4bfli	98	23	and	and	CC
cord-265900-7lj4bfli	98	24	release	release	VB
cord-265900-7lj4bfli	98	25	[	[	-LRB-
cord-265900-7lj4bfli	98	26	54	54	CD
cord-265900-7lj4bfli	98	27	]	]	-RRB-
cord-265900-7lj4bfli	98	28	[	[	-LRB-
cord-265900-7lj4bfli	98	29	55	55	CD
cord-265900-7lj4bfli	98	30	]	]	-RRB-
cord-265900-7lj4bfli	98	31	[	[	-LRB-
cord-265900-7lj4bfli	98	32	56	56	CD
cord-265900-7lj4bfli	98	33	]	]	-RRB-
cord-265900-7lj4bfli	98	34	.	.	.
cord-265900-7lj4bfli	99	1	The	the	DT
cord-265900-7lj4bfli	99	2	late	late	JJ
cord-265900-7lj4bfli	99	3	budding	bud	VBG
cord-265900-7lj4bfli	99	4	domain	domain	NN
cord-265900-7lj4bfli	99	5	in	in	IN
cord-265900-7lj4bfli	99	6	the	the	DT
cord-265900-7lj4bfli	99	7	Gag	Gag	NNP
cord-265900-7lj4bfli	99	8	protein	protein	NN
cord-265900-7lj4bfli	99	9	carries	carry	VBZ
cord-265900-7lj4bfli	99	10	conserved	conserved	JJ
cord-265900-7lj4bfli	99	11	motifs	motif	NNS
cord-265900-7lj4bfli	99	12	,	,	,
cord-265900-7lj4bfli	99	13	such	such	JJ
cord-265900-7lj4bfli	99	14	as	as	IN
cord-265900-7lj4bfli	99	15	PPXY	PPXY	NNP
cord-265900-7lj4bfli	99	16	and	and	CC
cord-265900-7lj4bfli	99	17	PTAP	PTAP	NNP
cord-265900-7lj4bfli	99	18	,	,	,
cord-265900-7lj4bfli	99	19	that	that	WDT
cord-265900-7lj4bfli	99	20	recruit	recruit	VBP
cord-265900-7lj4bfli	99	21	host	host	NN
cord-265900-7lj4bfli	99	22	WW	WW	NNP
cord-265900-7lj4bfli	99	23	domain	domain	NN
cord-265900-7lj4bfli	99	24	-	-	HYPH
cord-265900-7lj4bfli	99	25	containing	contain	VBG
cord-265900-7lj4bfli	99	26	HECT	HECT	NNP
cord-265900-7lj4bfli	99	27	E3	E3	NNP
cord-265900-7lj4bfli	99	28	ligase	ligase	NN
cord-265900-7lj4bfli	99	29	,	,	,
cord-265900-7lj4bfli	99	30	Nedd4	nedd4	JJ
cord-265900-7lj4bfli	99	31	to	to	TO
cord-265900-7lj4bfli	99	32	catalyze	catalyze	VB
cord-265900-7lj4bfli	99	33	the	the	DT
cord-265900-7lj4bfli	99	34	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	99	35	of	of	IN
cord-265900-7lj4bfli	99	36	Gag	Gag	NNP
cord-265900-7lj4bfli	99	37	[	[	-LRB-
cord-265900-7lj4bfli	99	38	57	57	CD
cord-265900-7lj4bfli	99	39	,	,	,
cord-265900-7lj4bfli	99	40	58	58	CD
cord-265900-7lj4bfli	99	41	]	]	-RRB-
cord-265900-7lj4bfli	99	42	.	.	.
cord-265900-7lj4bfli	100	1	Other	other	JJ
cord-265900-7lj4bfli	100	2	than	than	IN
cord-265900-7lj4bfli	100	3	Nedd4	Nedd4	NNP
cord-265900-7lj4bfli	100	4	,	,	,
cord-265900-7lj4bfli	100	5	the	the	DT
cord-265900-7lj4bfli	100	6	tumor	tumor	NN
cord-265900-7lj4bfli	100	7	susceptibility	susceptibility	NN
cord-265900-7lj4bfli	100	8	gene	gene	NN
cord-265900-7lj4bfli	100	9	101	101	CD
cord-265900-7lj4bfli	100	10	(	(	-LRB-
cord-265900-7lj4bfli	100	11	Tsg101	Tsg101	NNP
cord-265900-7lj4bfli	100	12	)	)	-RRB-
cord-265900-7lj4bfli	100	13	,	,	,
cord-265900-7lj4bfli	100	14	also	also	RB
cord-265900-7lj4bfli	100	15	binds	bind	VBZ
cord-265900-7lj4bfli	100	16	to	to	IN
cord-265900-7lj4bfli	100	17	the	the	DT
cord-265900-7lj4bfli	100	18	consensus	consensus	NN
cord-265900-7lj4bfli	100	19	motif	motif	NN
cord-265900-7lj4bfli	100	20	in	in	IN
cord-265900-7lj4bfli	100	21	Gag	Gag	NNP
cord-265900-7lj4bfli	100	22	and	and	CC
cord-265900-7lj4bfli	100	23	such	such	JJ
cord-265900-7lj4bfli	100	24	interaction	interaction	NN
cord-265900-7lj4bfli	100	25	is	be	VBZ
cord-265900-7lj4bfli	100	26	required	require	VBN
cord-265900-7lj4bfli	100	27	for	for	IN
cord-265900-7lj4bfli	100	28	viral	viral	JJ
cord-265900-7lj4bfli	100	29	budding	budding	NN
cord-265900-7lj4bfli	100	30	and	and	CC
cord-265900-7lj4bfli	100	31	release	release	VB
cord-265900-7lj4bfli	100	32	[	[	-LRB-
cord-265900-7lj4bfli	100	33	59	59	CD
cord-265900-7lj4bfli	100	34	,	,	,
cord-265900-7lj4bfli	100	35	60	60	CD
cord-265900-7lj4bfli	100	36	]	]	-RRB-
cord-265900-7lj4bfli	100	37	.	.	.
cord-265900-7lj4bfli	101	1	Tsg101	Tsg101	NNP
cord-265900-7lj4bfli	101	2	is	be	VBZ
cord-265900-7lj4bfli	101	3	a	a	DT
cord-265900-7lj4bfli	101	4	protein	protein	NN
cord-265900-7lj4bfli	101	5	of	of	IN
cord-265900-7lj4bfli	101	6	the	the	DT
cord-265900-7lj4bfli	101	7	endosomal	endosomal	NNP
cord-265900-7lj4bfli	101	8	sorting	sort	VBG
cord-265900-7lj4bfli	101	9	complex	complex	NN
cord-265900-7lj4bfli	101	10	required	require	VBN
cord-265900-7lj4bfli	101	11	for	for	IN
cord-265900-7lj4bfli	102	1	transport	transport	NN
cord-265900-7lj4bfli	102	2	(	(	-LRB-
cord-265900-7lj4bfli	102	3	ESCRT	ESCRT	NNP
cord-265900-7lj4bfli	102	4	)	)	-RRB-
cord-265900-7lj4bfli	102	5	complex	complex	NN
cord-265900-7lj4bfli	102	6	and	and	CC
cord-265900-7lj4bfli	102	7	is	be	VBZ
cord-265900-7lj4bfli	102	8	involved	involve	VBN
cord-265900-7lj4bfli	102	9	in	in	IN
cord-265900-7lj4bfli	102	10	vacuolar	vacuolar	NNP
cord-265900-7lj4bfli	102	11	protein	protein	NN
cord-265900-7lj4bfli	102	12	sorting	sorting	NN
cord-265900-7lj4bfli	102	13	and	and	CC
cord-265900-7lj4bfli	102	14	biogenesis	biogenesis	NN
cord-265900-7lj4bfli	102	15	of	of	IN
cord-265900-7lj4bfli	102	16	multivesicular	multivesicular	NNP
cord-265900-7lj4bfli	102	17	body	body	NN
cord-265900-7lj4bfli	102	18	.	.	.
cord-265900-7lj4bfli	103	1	Similarly	similarly	RB
cord-265900-7lj4bfli	103	2	,	,	,
cord-265900-7lj4bfli	103	3	it	-PRON-	PRP
cord-265900-7lj4bfli	103	4	was	be	VBD
cord-265900-7lj4bfli	103	5	found	find	VBN
cord-265900-7lj4bfli	103	6	that	that	IN
cord-265900-7lj4bfli	103	7	the	the	DT
cord-265900-7lj4bfli	103	8	p33	p33	CD
cord-265900-7lj4bfli	103	9	replication	replication	NN
cord-265900-7lj4bfli	103	10	protein	protein	NN
cord-265900-7lj4bfli	103	11	of	of	IN
cord-265900-7lj4bfli	103	12	Tomato	Tomato	NNP
cord-265900-7lj4bfli	103	13	bushy	bushy	JJ
cord-265900-7lj4bfli	103	14	stunt	stunt	NN
cord-265900-7lj4bfli	103	15	virus	virus	NN
cord-265900-7lj4bfli	103	16	is	be	VBZ
cord-265900-7lj4bfli	103	17	ubiquitinated	ubiquitinate	VBN
cord-265900-7lj4bfli	103	18	and	and	CC
cord-265900-7lj4bfli	103	19	this	this	DT
cord-265900-7lj4bfli	103	20	modification	modification	NN
cord-265900-7lj4bfli	103	21	does	do	VBZ
cord-265900-7lj4bfli	103	22	not	not	RB
cord-265900-7lj4bfli	103	23	affect	affect	VB
cord-265900-7lj4bfli	103	24	its	-PRON-	PRP$
cord-265900-7lj4bfli	103	25	stability	stability	NN
cord-265900-7lj4bfli	103	26	,	,	,
cord-265900-7lj4bfli	103	27	but	but	CC
cord-265900-7lj4bfli	103	28	instead	instead	RB
cord-265900-7lj4bfli	103	29	enhances	enhance	VBZ
cord-265900-7lj4bfli	103	30	its	-PRON-	PRP$
cord-265900-7lj4bfli	103	31	interaction	interaction	NN
cord-265900-7lj4bfli	103	32	with	with	IN
cord-265900-7lj4bfli	103	33	ESCRT	ESCRT	NNP
cord-265900-7lj4bfli	103	34	proteins	protein	NNS
cord-265900-7lj4bfli	103	35	,	,	,
cord-265900-7lj4bfli	103	36	contributing	contribute	VBG
cord-265900-7lj4bfli	103	37	to	to	IN
cord-265900-7lj4bfli	103	38	effective	effective	JJ
cord-265900-7lj4bfli	103	39	viral	viral	JJ
cord-265900-7lj4bfli	103	40	replication	replication	NN
cord-265900-7lj4bfli	103	41	[	[	-LRB-
cord-265900-7lj4bfli	103	42	61	61	CD
cord-265900-7lj4bfli	103	43	,	,	,
cord-265900-7lj4bfli	103	44	62	62	CD
cord-265900-7lj4bfli	103	45	]	]	-RRB-
cord-265900-7lj4bfli	103	46	.	.	.
cord-265900-7lj4bfli	104	1	Moreover	moreover	RB
cord-265900-7lj4bfli	104	2	,	,	,
cord-265900-7lj4bfli	104	3	ubiquitination	ubiquitination	IN
cord-265900-7lj4bfli	104	4	of	of	IN
cord-265900-7lj4bfli	104	5	the	the	DT
cord-265900-7lj4bfli	104	6	HIV-1	HIV-1	NNP
cord-265900-7lj4bfli	104	7	Tat	Tat	NNP
cord-265900-7lj4bfli	104	8	protein	protein	NN
cord-265900-7lj4bfli	104	9	and	and	CC
cord-265900-7lj4bfli	104	10	the	the	DT
cord-265900-7lj4bfli	104	11	human	human	JJ
cord-265900-7lj4bfli	104	12	T	t	NN
cord-265900-7lj4bfli	104	13	-	-	HYPH
cord-265900-7lj4bfli	104	14	cell	cell	NN
cord-265900-7lj4bfli	104	15	leukemia	leukemia	NN
cord-265900-7lj4bfli	104	16	virus	virus	NN
cord-265900-7lj4bfli	104	17	type	type	NN
cord-265900-7lj4bfli	104	18	1	1	CD
cord-265900-7lj4bfli	104	19	Tax	tax	NN
cord-265900-7lj4bfli	104	20	protein	protein	NN
cord-265900-7lj4bfli	104	21	was	be	VBD
cord-265900-7lj4bfli	104	22	demonstrated	demonstrate	VBN
cord-265900-7lj4bfli	104	23	to	to	TO
cord-265900-7lj4bfli	104	24	enhance	enhance	VB
cord-265900-7lj4bfli	104	25	their	-PRON-	PRP$
cord-265900-7lj4bfli	104	26	transactivation	transactivation	NN
cord-265900-7lj4bfli	104	27	activities	activity	NNS
cord-265900-7lj4bfli	104	28	without	without	IN
cord-265900-7lj4bfli	104	29	targeting	target	VBG
cord-265900-7lj4bfli	104	30	them	-PRON-	PRP
cord-265900-7lj4bfli	104	31	for	for	IN
cord-265900-7lj4bfli	104	32	degradation	degradation	NN
cord-265900-7lj4bfli	104	33	[	[	-LRB-
cord-265900-7lj4bfli	104	34	63	63	CD
cord-265900-7lj4bfli	104	35	,	,	,
cord-265900-7lj4bfli	104	36	64	64	CD
cord-265900-7lj4bfli	104	37	]	]	-RRB-
cord-265900-7lj4bfli	104	38	.	.	.
cord-265900-7lj4bfli	105	1	The	the	DT
cord-265900-7lj4bfli	105	2	RNA	RNA	NNP
cord-265900-7lj4bfli	105	3	-	-	HYPH
cord-265900-7lj4bfli	105	4	dependent	dependent	JJ
cord-265900-7lj4bfli	105	5	RNA	RNA	NNP
cord-265900-7lj4bfli	105	6	polymerase	polymerase	NN
cord-265900-7lj4bfli	105	7	(	(	-LRB-
cord-265900-7lj4bfli	105	8	RdRp	RdRp	NNP
cord-265900-7lj4bfli	105	9	)	)	-RRB-
cord-265900-7lj4bfli	105	10	encoded	encode	VBN
cord-265900-7lj4bfli	105	11	by	by	IN
cord-265900-7lj4bfli	105	12	coxsackievirus	coxsackievirus	NNP
cord-265900-7lj4bfli	105	13	provides	provide	VBZ
cord-265900-7lj4bfli	105	14	another	another	DT
cord-265900-7lj4bfli	105	15	example	example	NN
cord-265900-7lj4bfli	105	16	of	of	IN
cord-265900-7lj4bfli	105	17	viral	viral	JJ
cord-265900-7lj4bfli	105	18	protein	protein	NN
cord-265900-7lj4bfli	105	19	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	105	20	and	and	CC
cord-265900-7lj4bfli	105	21	activation	activation	NN
cord-265900-7lj4bfli	105	22	during	during	IN
cord-265900-7lj4bfli	105	23	infection	infection	NN
cord-265900-7lj4bfli	105	24	[	[	-LRB-
cord-265900-7lj4bfli	105	25	65	65	CD
cord-265900-7lj4bfli	105	26	]	]	-RRB-
cord-265900-7lj4bfli	105	27	.	.	.
cord-265900-7lj4bfli	106	1	Finally	finally	RB
cord-265900-7lj4bfli	106	2	,	,	,
cord-265900-7lj4bfli	106	3	certain	certain	JJ
cord-265900-7lj4bfli	106	4	viral	viral	JJ
cord-265900-7lj4bfli	106	5	structural	structural	JJ
cord-265900-7lj4bfli	106	6	proteins	protein	NNS
cord-265900-7lj4bfli	106	7	,	,	,
cord-265900-7lj4bfli	106	8	such	such	JJ
cord-265900-7lj4bfli	106	9	as	as	IN
cord-265900-7lj4bfli	106	10	the	the	DT
cord-265900-7lj4bfli	106	11	envelope	envelope	NN
cord-265900-7lj4bfli	106	12	protein	protein	NN
cord-265900-7lj4bfli	106	13	of	of	IN
cord-265900-7lj4bfli	106	14	severe	severe	JJ
cord-265900-7lj4bfli	106	15	acute	acute	JJ
cord-265900-7lj4bfli	106	16	respiratory	respiratory	JJ
cord-265900-7lj4bfli	106	17	syndrome	syndrome	NN
cord-265900-7lj4bfli	106	18	coronavirus	coronavirus	NN
cord-265900-7lj4bfli	106	19	(	(	-LRB-
cord-265900-7lj4bfli	106	20	SARS	SARS	NNP
cord-265900-7lj4bfli	106	21	-	-	HYPH
cord-265900-7lj4bfli	106	22	CoV	CoV	NNP
cord-265900-7lj4bfli	106	23	)	)	-RRB-
cord-265900-7lj4bfli	106	24	[	[	-LRB-
cord-265900-7lj4bfli	106	25	66	66	CD
cord-265900-7lj4bfli	106	26	]	]	-RRB-
cord-265900-7lj4bfli	106	27	and	and	CC
cord-265900-7lj4bfli	106	28	structural	structural	JJ
cord-265900-7lj4bfli	106	29	proteins	protein	NNS
cord-265900-7lj4bfli	106	30	of	of	IN
cord-265900-7lj4bfli	106	31	several	several	JJ
cord-265900-7lj4bfli	106	32	plant	plant	NN
cord-265900-7lj4bfli	106	33	viruses	virus	NNS
cord-265900-7lj4bfli	106	34	[	[	-LRB-
cord-265900-7lj4bfli	106	35	67	67	CD
cord-265900-7lj4bfli	106	36	]	]	-RRB-
cord-265900-7lj4bfli	106	37	,	,	,
cord-265900-7lj4bfli	106	38	were	be	VBD
cord-265900-7lj4bfli	106	39	also	also	RB
cord-265900-7lj4bfli	106	40	found	find	VBN
cord-265900-7lj4bfli	106	41	to	to	TO
cord-265900-7lj4bfli	106	42	be	be	VB
cord-265900-7lj4bfli	106	43	ubiquitinated	ubiquitinate	VBN
cord-265900-7lj4bfli	106	44	although	although	IN
cord-265900-7lj4bfli	106	45	the	the	DT
cord-265900-7lj4bfli	106	46	functional	functional	JJ
cord-265900-7lj4bfli	106	47	consequence	consequence	NN
cord-265900-7lj4bfli	106	48	of	of	IN
cord-265900-7lj4bfli	106	49	such	such	JJ
cord-265900-7lj4bfli	106	50	modification	modification	NN
cord-265900-7lj4bfli	106	51	remains	remain	VBZ
cord-265900-7lj4bfli	106	52	elusive	elusive	JJ
cord-265900-7lj4bfli	106	53	.	.	.
cord-265900-7lj4bfli	107	1	Some	some	DT
cord-265900-7lj4bfli	107	2	viral	viral	JJ
cord-265900-7lj4bfli	107	3	functions	function	NNS
cord-265900-7lj4bfli	107	4	also	also	RB
cord-265900-7lj4bfli	107	5	require	require	VBP
cord-265900-7lj4bfli	107	6	SUMO	SUMO	NNP
cord-265900-7lj4bfli	107	7	modification	modification	NN
cord-265900-7lj4bfli	107	8	.	.	.
cord-265900-7lj4bfli	108	1	For	for	IN
cord-265900-7lj4bfli	108	2	example	example	NN
cord-265900-7lj4bfli	108	3	,	,	,
cord-265900-7lj4bfli	108	4	the	the	DT
cord-265900-7lj4bfli	108	5	immediate	immediate	JJ
cord-265900-7lj4bfli	108	6	-	-	HYPH
cord-265900-7lj4bfli	108	7	early	early	JJ
cord-265900-7lj4bfli	108	8	(	(	-LRB-
cord-265900-7lj4bfli	108	9	IE	IE	NNP
cord-265900-7lj4bfli	108	10	)	)	-RRB-
cord-265900-7lj4bfli	108	11	IE1	ie1	NN
cord-265900-7lj4bfli	108	12	and	and	CC
cord-265900-7lj4bfli	108	13	IE2	ie2	NN
cord-265900-7lj4bfli	108	14	proteins	protein	NNS
cord-265900-7lj4bfli	108	15	of	of	IN
cord-265900-7lj4bfli	108	16	HCMV	HCMV	NNP
cord-265900-7lj4bfli	108	17	are	be	VBP
cord-265900-7lj4bfli	108	18	covalently	covalently	RB
cord-265900-7lj4bfli	108	19	modified	modify	VBN
cord-265900-7lj4bfli	108	20	by	by	IN
cord-265900-7lj4bfli	108	21	SUMO	SUMO	NNP
cord-265900-7lj4bfli	108	22	following	follow	VBG
cord-265900-7lj4bfli	108	23	infection	infection	NN
cord-265900-7lj4bfli	108	24	[	[	-LRB-
cord-265900-7lj4bfli	108	25	68	68	CD
cord-265900-7lj4bfli	108	26	,	,	,
cord-265900-7lj4bfli	108	27	69	69	CD
cord-265900-7lj4bfli	108	28	]	]	-RRB-
cord-265900-7lj4bfli	108	29	.	.	.
cord-265900-7lj4bfli	109	1	Although	although	IN
cord-265900-7lj4bfli	109	2	the	the	DT
cord-265900-7lj4bfli	109	3	exact	exact	JJ
cord-265900-7lj4bfli	109	4	role	role	NN
cord-265900-7lj4bfli	109	5	of	of	IN
cord-265900-7lj4bfli	109	6	sumoylation	sumoylation	NN
cord-265900-7lj4bfli	109	7	in	in	IN
cord-265900-7lj4bfli	109	8	viral	viral	JJ
cord-265900-7lj4bfli	109	9	pathogenesis	pathogenesis	NN
cord-265900-7lj4bfli	109	10	is	be	VBZ
cord-265900-7lj4bfli	109	11	still	still	RB
cord-265900-7lj4bfli	109	12	unclear	unclear	JJ
cord-265900-7lj4bfli	109	13	,	,	,
cord-265900-7lj4bfli	109	14	sumoylation	sumoylation	NN
cord-265900-7lj4bfli	109	15	-	-	HYPH
cord-265900-7lj4bfli	109	16	resistant	resistant	JJ
cord-265900-7lj4bfli	109	17	mutant	mutant	NN
cord-265900-7lj4bfli	109	18	of	of	IN
cord-265900-7lj4bfli	109	19	HCMV	HCMV	NNP
cord-265900-7lj4bfli	109	20	IE1	IE1	NNP
cord-265900-7lj4bfli	109	21	was	be	VBD
cord-265900-7lj4bfli	109	22	found	find	VBN
cord-265900-7lj4bfli	109	23	to	to	TO
cord-265900-7lj4bfli	109	24	exhibit	exhibit	VB
cord-265900-7lj4bfli	109	25	attenuated	attenuated	JJ
cord-265900-7lj4bfli	109	26	viral	viral	JJ
cord-265900-7lj4bfli	109	27	growth	growth	NN
cord-265900-7lj4bfli	109	28	,	,	,
cord-265900-7lj4bfli	109	29	indicating	indicate	VBG
cord-265900-7lj4bfli	109	30	a	a	DT
cord-265900-7lj4bfli	109	31	role	role	NN
cord-265900-7lj4bfli	109	32	for	for	IN
cord-265900-7lj4bfli	109	33	SUMO	SUMO	NNP
cord-265900-7lj4bfli	109	34	modification	modification	NN
cord-265900-7lj4bfli	109	35	in	in	IN
cord-265900-7lj4bfli	109	36	regulating	regulate	VBG
cord-265900-7lj4bfli	109	37	viral	viral	JJ
cord-265900-7lj4bfli	109	38	protein	protein	NN
cord-265900-7lj4bfli	109	39	function	function	NN
cord-265900-7lj4bfli	109	40	and	and	CC
cord-265900-7lj4bfli	109	41	replication	replication	NN
cord-265900-7lj4bfli	109	42	[	[	-LRB-
cord-265900-7lj4bfli	109	43	70	70	CD
cord-265900-7lj4bfli	109	44	]	]	-RRB-
cord-265900-7lj4bfli	109	45	.	.	.
cord-265900-7lj4bfli	110	1	The	the	DT
cord-265900-7lj4bfli	110	2	adenoviral	adenoviral	NNP
cord-265900-7lj4bfli	110	3	E1B55k	E1B55k	NNP
cord-265900-7lj4bfli	110	4	protein	protein	NN
cord-265900-7lj4bfli	110	5	is	be	VBZ
cord-265900-7lj4bfli	110	6	another	another	DT
cord-265900-7lj4bfli	110	7	example	example	NN
cord-265900-7lj4bfli	110	8	of	of	IN
cord-265900-7lj4bfli	110	9	viral	viral	JJ
cord-265900-7lj4bfli	110	10	protein	protein	NN
cord-265900-7lj4bfli	110	11	modification	modification	NN
cord-265900-7lj4bfli	110	12	by	by	IN
cord-265900-7lj4bfli	110	13	SUMO	SUMO	NNP
cord-265900-7lj4bfli	110	14	and	and	CC
cord-265900-7lj4bfli	110	15	this	this	DT
cord-265900-7lj4bfli	110	16	modification	modification	NN
cord-265900-7lj4bfli	110	17	appears	appear	VBZ
cord-265900-7lj4bfli	110	18	to	to	TO
cord-265900-7lj4bfli	110	19	be	be	VB
cord-265900-7lj4bfli	110	20	required	require	VBN
cord-265900-7lj4bfli	110	21	for	for	IN
cord-265900-7lj4bfli	110	22	its	-PRON-	PRP$
cord-265900-7lj4bfli	110	23	function	function	NN
cord-265900-7lj4bfli	110	24	in	in	IN
cord-265900-7lj4bfli	110	25	modulating	modulate	VBG
cord-265900-7lj4bfli	110	26	cell	cell	NN
cord-265900-7lj4bfli	110	27	cycle	cycle	NN
cord-265900-7lj4bfli	110	28	progression	progression	NN
cord-265900-7lj4bfli	110	29	and	and	CC
cord-265900-7lj4bfli	110	30	apoptosis	apoptosis	NN
cord-265900-7lj4bfli	110	31	as	as	IN
cord-265900-7lj4bfli	110	32	a	a	DT
cord-265900-7lj4bfli	110	33	sumoylation	sumoylation	NN
cord-265900-7lj4bfli	110	34	-	-	HYPH
cord-265900-7lj4bfli	110	35	deficient	deficient	JJ
cord-265900-7lj4bfli	110	36	mutant	mutant	NN
cord-265900-7lj4bfli	110	37	of	of	IN
cord-265900-7lj4bfli	110	38	E1B55k	E1B55k	NNP
cord-265900-7lj4bfli	110	39	fails	fail	VBZ
cord-265900-7lj4bfli	110	40	to	to	TO
cord-265900-7lj4bfli	110	41	interact	interact	VB
cord-265900-7lj4bfli	110	42	with	with	IN
cord-265900-7lj4bfli	110	43	p53	p53	NN
cord-265900-7lj4bfli	110	44	and	and	CC
cord-265900-7lj4bfli	110	45	inhibit	inhibit	VB
cord-265900-7lj4bfli	110	46	p53-mediated	p53-mediate	VBN
cord-265900-7lj4bfli	110	47	transactivation	transactivation	NN
cord-265900-7lj4bfli	110	48	[	[	-LRB-
cord-265900-7lj4bfli	110	49	71	71	CD
cord-265900-7lj4bfli	110	50	,	,	,
cord-265900-7lj4bfli	110	51	72	72	CD
cord-265900-7lj4bfli	110	52	]	]	-RRB-
cord-265900-7lj4bfli	110	53	.	.	.
cord-265900-7lj4bfli	111	1	Furthermore	furthermore	RB
cord-265900-7lj4bfli	111	2	,	,	,
cord-265900-7lj4bfli	111	3	it	-PRON-	PRP
cord-265900-7lj4bfli	111	4	was	be	VBD
cord-265900-7lj4bfli	111	5	reported	report	VBN
cord-265900-7lj4bfli	111	6	that	that	IN
cord-265900-7lj4bfli	111	7	the	the	DT
cord-265900-7lj4bfli	111	8	papillomavirus	papillomavirus	NN
cord-265900-7lj4bfli	111	9	E1	e1	NN
cord-265900-7lj4bfli	111	10	protein	protein	NN
cord-265900-7lj4bfli	111	11	interacts	interact	VBZ
cord-265900-7lj4bfli	111	12	with	with	IN
cord-265900-7lj4bfli	111	13	SUMO	SUMO	NNP
cord-265900-7lj4bfli	111	14	E2	E2	NNP
cord-265900-7lj4bfli	111	15	enzyme	enzyme	NN
cord-265900-7lj4bfli	111	16	Ubc9	Ubc9	NNP
cord-265900-7lj4bfli	111	17	and	and	CC
cord-265900-7lj4bfli	111	18	E3	E3	NNP
cord-265900-7lj4bfli	111	19	enzyme	enzyme	NN
cord-265900-7lj4bfli	111	20	PIAS	PIAS	NNP
cord-265900-7lj4bfli	111	21	to	to	TO
cord-265900-7lj4bfli	111	22	support	support	VB
cord-265900-7lj4bfli	111	23	viral	viral	JJ
cord-265900-7lj4bfli	111	24	replication	replication	NN
cord-265900-7lj4bfli	111	25	and	and	CC
cord-265900-7lj4bfli	111	26	disruption	disruption	NN
cord-265900-7lj4bfli	111	27	of	of	IN
cord-265900-7lj4bfli	111	28	their	-PRON-	PRP$
cord-265900-7lj4bfli	111	29	association	association	NN
cord-265900-7lj4bfli	111	30	leads	lead	VBZ
cord-265900-7lj4bfli	111	31	to	to	IN
cord-265900-7lj4bfli	111	32	reduced	reduce	VBN
cord-265900-7lj4bfli	111	33	viral	viral	JJ
cord-265900-7lj4bfli	111	34	virulence	virulence	NN
cord-265900-7lj4bfli	111	35	[	[	-LRB-
cord-265900-7lj4bfli	111	36	73	73	CD
cord-265900-7lj4bfli	111	37	,	,	,
cord-265900-7lj4bfli	111	38	74	74	CD
cord-265900-7lj4bfli	111	39	]	]	-RRB-
cord-265900-7lj4bfli	111	40	.	.	.
cord-265900-7lj4bfli	112	1	Besides	besides	IN
cord-265900-7lj4bfli	112	2	animal	animal	NN
cord-265900-7lj4bfli	112	3	viruses	virus	NNS
cord-265900-7lj4bfli	112	4	,	,	,
cord-265900-7lj4bfli	112	5	viral	viral	JJ
cord-265900-7lj4bfli	112	6	protein	protein	NN
cord-265900-7lj4bfli	112	7	modification	modification	NN
cord-265900-7lj4bfli	112	8	by	by	IN
cord-265900-7lj4bfli	112	9	SU	SU	NNP
cord-265900-7lj4bfli	112	10	-	-	HYPH
cord-265900-7lj4bfli	112	11	MO	MO	NNP
cord-265900-7lj4bfli	112	12	was	be	VBD
cord-265900-7lj4bfli	112	13	also	also	RB
cord-265900-7lj4bfli	112	14	observed	observe	VBN
cord-265900-7lj4bfli	112	15	in	in	IN
cord-265900-7lj4bfli	112	16	plant	plant	NN
cord-265900-7lj4bfli	112	17	viruses	virus	NNS
cord-265900-7lj4bfli	112	18	.	.	.
cord-265900-7lj4bfli	113	1	It	-PRON-	PRP
cord-265900-7lj4bfli	113	2	was	be	VBD
cord-265900-7lj4bfli	113	3	found	find	VBN
cord-265900-7lj4bfli	113	4	that	that	IN
cord-265900-7lj4bfli	113	5	the	the	DT
cord-265900-7lj4bfli	113	6	RepAC1	RepAC1	NNP
cord-265900-7lj4bfli	113	7	/	/	SYM
cord-265900-7lj4bfli	113	8	Rep	Rep	NNP
cord-265900-7lj4bfli	113	9	protein	protein	NN
cord-265900-7lj4bfli	113	10	,	,	,
cord-265900-7lj4bfli	113	11	encoded	encode	VBN
cord-265900-7lj4bfli	113	12	by	by	IN
cord-265900-7lj4bfli	113	13	Tomato	Tomato	NNP
cord-265900-7lj4bfli	113	14	golden	golden	JJ
cord-265900-7lj4bfli	113	15	mosaic	mosaic	JJ
cord-265900-7lj4bfli	113	16	virus	virus	NN
cord-265900-7lj4bfli	113	17	and	and	CC
cord-265900-7lj4bfli	113	18	Tomato	Tomato	NNP
cord-265900-7lj4bfli	113	19	yellow	yellow	JJ
cord-265900-7lj4bfli	113	20	leaf	leaf	NN
cord-265900-7lj4bfli	113	21	curl	curl	NN
cord-265900-7lj4bfli	113	22	Sardinia	Sardinia	NNP
cord-265900-7lj4bfli	113	23	virus	virus	NN
cord-265900-7lj4bfli	113	24	,	,	,
cord-265900-7lj4bfli	113	25	binds	bind	VBZ
cord-265900-7lj4bfli	113	26	to	to	IN
cord-265900-7lj4bfli	113	27	SCE1	SCE1	NNP
cord-265900-7lj4bfli	113	28	(	(	-LRB-
cord-265900-7lj4bfli	113	29	SUMO	SUMO	NNP
cord-265900-7lj4bfli	113	30	-	-	HYPH
cord-265900-7lj4bfli	113	31	conjugating	conjugate	VBG
cord-265900-7lj4bfli	113	32	enzyme	enzyme	NN
cord-265900-7lj4bfli	113	33	)	)	-RRB-
cord-265900-7lj4bfli	113	34	,	,	,
cord-265900-7lj4bfli	113	35	a	a	DT
cord-265900-7lj4bfli	113	36	plant	plant	NN
cord-265900-7lj4bfli	113	37	homology	homology	NN
cord-265900-7lj4bfli	113	38	to	to	IN
cord-265900-7lj4bfli	113	39	Ubc9	Ubc9	NNP
cord-265900-7lj4bfli	113	40	,	,	,
cord-265900-7lj4bfli	113	41	and	and	CC
cord-265900-7lj4bfli	113	42	sumoylation	sumoylation	NN
cord-265900-7lj4bfli	113	43	plays	play	VBZ
cord-265900-7lj4bfli	113	44	an	an	DT
cord-265900-7lj4bfli	113	45	important	important	JJ
cord-265900-7lj4bfli	113	46	role	role	NN
cord-265900-7lj4bfli	113	47	in	in	IN
cord-265900-7lj4bfli	113	48	viral	viral	JJ
cord-265900-7lj4bfli	113	49	replication	replication	NN
cord-265900-7lj4bfli	113	50	[	[	-LRB-
cord-265900-7lj4bfli	113	51	75	75	CD
cord-265900-7lj4bfli	113	52	]	]	-RRB-
cord-265900-7lj4bfli	113	53	.	.	.
cord-265900-7lj4bfli	114	1	It	-PRON-	PRP
cord-265900-7lj4bfli	114	2	was	be	VBD
cord-265900-7lj4bfli	114	3	also	also	RB
cord-265900-7lj4bfli	114	4	demonstrated	demonstrate	VBN
cord-265900-7lj4bfli	114	5	that	that	IN
cord-265900-7lj4bfli	114	6	the	the	DT
cord-265900-7lj4bfli	114	7	RdRp	RdRp	NNP
cord-265900-7lj4bfli	114	8	of	of	IN
cord-265900-7lj4bfli	114	9	Turnip	Turnip	NNP
cord-265900-7lj4bfli	114	10	mosaic	mosaic	JJ
cord-265900-7lj4bfli	114	11	virus	virus	NN
cord-265900-7lj4bfli	114	12	undergoes	undergo	VBZ
cord-265900-7lj4bfli	114	13	SUMO	SUMO	NNP
cord-265900-7lj4bfli	114	14	modification	modification	NN
cord-265900-7lj4bfli	114	15	via	via	IN
cord-265900-7lj4bfli	114	16	its	-PRON-	PRP$
cord-265900-7lj4bfli	114	17	interaction	interaction	NN
cord-265900-7lj4bfli	114	18	with	with	IN
cord-265900-7lj4bfli	114	19	SCE1	SCE1	NNP
cord-265900-7lj4bfli	114	20	and	and	CC
cord-265900-7lj4bfli	114	21	such	such	JJ
cord-265900-7lj4bfli	114	22	modification	modification	NN
cord-265900-7lj4bfli	114	23	is	be	VBZ
cord-265900-7lj4bfli	114	24	required	require	VBN
cord-265900-7lj4bfli	114	25	for	for	IN
cord-265900-7lj4bfli	114	26	viral	viral	JJ
cord-265900-7lj4bfli	114	27	infection	infection	NN
cord-265900-7lj4bfli	114	28	[	[	-LRB-
cord-265900-7lj4bfli	114	29	76	76	CD
cord-265900-7lj4bfli	114	30	]	]	-RRB-
cord-265900-7lj4bfli	114	31	.	.	.
cord-265900-7lj4bfli	115	1	ISG15	ISG15	NNP
cord-265900-7lj4bfli	115	2	and	and	CC
cord-265900-7lj4bfli	115	3	the	the	DT
cord-265900-7lj4bfli	115	4	ISGylation	ISGylation	NNP
cord-265900-7lj4bfli	115	5	conjugation	conjugation	NN
cord-265900-7lj4bfli	115	6	system	system	NN
cord-265900-7lj4bfli	115	7	represent	represent	VBP
cord-265900-7lj4bfli	115	8	an	an	DT
cord-265900-7lj4bfli	115	9	important	important	JJ
cord-265900-7lj4bfli	115	10	host	host	NN
cord-265900-7lj4bfli	115	11	defense	defense	NN
cord-265900-7lj4bfli	115	12	mechanism	mechanism	NN
cord-265900-7lj4bfli	115	13	against	against	IN
cord-265900-7lj4bfli	115	14	infection	infection	NN
cord-265900-7lj4bfli	115	15	of	of	IN
cord-265900-7lj4bfli	115	16	a	a	DT
cord-265900-7lj4bfli	115	17	broad	broad	JJ
cord-265900-7lj4bfli	115	18	spectrum	spectrum	NN
cord-265900-7lj4bfli	115	19	of	of	IN
cord-265900-7lj4bfli	115	20	viruses	virus	NNS
cord-265900-7lj4bfli	115	21	,	,	,
cord-265900-7lj4bfli	115	22	including	include	VBG
cord-265900-7lj4bfli	115	23	Sindbis	Sindbis	NNP
cord-265900-7lj4bfli	115	24	virus	virus	NN
cord-265900-7lj4bfli	115	25	,	,	,
cord-265900-7lj4bfli	115	26	Viral	viral	JJ
cord-265900-7lj4bfli	115	27	interaction	interaction	NN
cord-265900-7lj4bfli	115	28	with	with	IN
cord-265900-7lj4bfli	115	29	the	the	DT
cord-265900-7lj4bfli	115	30	host	host	NN
cord-265900-7lj4bfli	115	31	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	115	32	-	-	HYPH
cord-265900-7lj4bfli	115	33	proteasome	proteasome	VBN
cord-265900-7lj4bfli	115	34	system	system	NN
cord-265900-7lj4bfli	115	35	(	(	-LRB-
cord-265900-7lj4bfli	115	36	UPS	UPS	NNP
cord-265900-7lj4bfli	115	37	)	)	-RRB-
cord-265900-7lj4bfli	115	38	:	:	:
cord-265900-7lj4bfli	115	39	pro	pro	JJ
cord-265900-7lj4bfli	115	40	-	-	JJ
cord-265900-7lj4bfli	115	41	viral	viral	JJ
cord-265900-7lj4bfli	115	42	and	and	CC
cord-265900-7lj4bfli	115	43	anti	anti	JJ
cord-265900-7lj4bfli	115	44	-	-	JJ
cord-265900-7lj4bfli	115	45	viral	viral	JJ
cord-265900-7lj4bfli	115	46	function	function	NN
cord-265900-7lj4bfli	115	47	of	of	IN
cord-265900-7lj4bfli	115	48	the	the	DT
cord-265900-7lj4bfli	115	49	UPS	up	NNS
cord-265900-7lj4bfli	115	50	in	in	IN
cord-265900-7lj4bfli	115	51	viral	viral	JJ
cord-265900-7lj4bfli	115	52	pathogenesis	pathogenesis	NN
cord-265900-7lj4bfli	115	53	.	.	.
cord-265900-7lj4bfli	116	1	The	the	DT
cord-265900-7lj4bfli	116	2	UPS	up	NNS
cord-265900-7lj4bfli	116	3	,	,	,
cord-265900-7lj4bfli	116	4	including	include	VBG
cord-265900-7lj4bfli	116	5	modification	modification	NN
cord-265900-7lj4bfli	116	6	of	of	IN
cord-265900-7lj4bfli	116	7	key	key	JJ
cord-265900-7lj4bfli	116	8	signaling	signal	VBG
cord-265900-7lj4bfli	116	9	molecules	molecule	NNS
cord-265900-7lj4bfli	116	10	involved	involve	VBN
cord-265900-7lj4bfli	116	11	in	in	IN
cord-265900-7lj4bfli	116	12	innate	innate	JJ
cord-265900-7lj4bfli	116	13	immunity	immunity	NN
cord-265900-7lj4bfli	116	14	by	by	IN
cord-265900-7lj4bfli	116	15	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	116	16	or	or	CC
cord-265900-7lj4bfli	116	17	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	116	18	-	-	HYPH
cord-265900-7lj4bfli	116	19	like	like	JJ
cord-265900-7lj4bfli	116	20	modifiers	modifier	NNS
cord-265900-7lj4bfli	116	21	(	(	-LRB-
cord-265900-7lj4bfli	116	22	e.g.	e.g.	JJ
cord-265900-7lj4bfli	116	23	SUMO	SUMO	NNP
cord-265900-7lj4bfli	116	24	and	and	CC
cord-265900-7lj4bfli	116	25	ISG15	ISG15	NNP
cord-265900-7lj4bfli	116	26	)	)	-RRB-
cord-265900-7lj4bfli	116	27	,	,	,
cord-265900-7lj4bfli	116	28	represents	represent	VBZ
cord-265900-7lj4bfli	116	29	an	an	DT
cord-265900-7lj4bfli	116	30	important	important	JJ
cord-265900-7lj4bfli	116	31	host	host	NN
cord-265900-7lj4bfli	116	32	anti	anti	JJ
cord-265900-7lj4bfli	116	33	-	-	JJ
cord-265900-7lj4bfli	116	34	viral	viral	JJ
cord-265900-7lj4bfli	116	35	defense	defense	NN
cord-265900-7lj4bfli	116	36	mechanism	mechanism	NN
cord-265900-7lj4bfli	116	37	.	.	.
cord-265900-7lj4bfli	117	1	Many	many	JJ
cord-265900-7lj4bfli	117	2	viruses	virus	NNS
cord-265900-7lj4bfli	117	3	have	have	VBP
cord-265900-7lj4bfli	117	4	evolved	evolve	VBN
cord-265900-7lj4bfli	117	5	to	to	TO
cord-265900-7lj4bfli	117	6	subvert	subvert	VB
cord-265900-7lj4bfli	117	7	or	or	CC
cord-265900-7lj4bfli	117	8	manipulate	manipulate	VB
cord-265900-7lj4bfli	117	9	this	this	DT
cord-265900-7lj4bfli	117	10	cellular	cellular	JJ
cord-265900-7lj4bfli	117	11	machinery	machinery	NN
cord-265900-7lj4bfli	117	12	to	to	TO
cord-265900-7lj4bfli	117	13	favor	favor	VB
cord-265900-7lj4bfli	117	14	their	-PRON-	PRP$
cord-265900-7lj4bfli	117	15	growth	growth	NN
cord-265900-7lj4bfli	117	16	and	and	CC
cord-265900-7lj4bfli	117	17	to	to	TO
cord-265900-7lj4bfli	117	18	escape	escape	VB
cord-265900-7lj4bfli	117	19	host	host	NN
cord-265900-7lj4bfli	117	20	immune	immune	JJ
cord-265900-7lj4bfli	117	21	response	response	NN
cord-265900-7lj4bfli	117	22	.	.	.
cord-265900-7lj4bfli	118	1	In	in	IN
cord-265900-7lj4bfli	118	2	some	some	DT
cord-265900-7lj4bfli	118	3	cases	case	NNS
cord-265900-7lj4bfli	118	4	,	,	,
cord-265900-7lj4bfli	118	5	viruses	virus	NNS
cord-265900-7lj4bfli	118	6	encode	encode	VBP
cord-265900-7lj4bfli	118	7	proteins	protein	NNS
cord-265900-7lj4bfli	118	8	with	with	IN
cord-265900-7lj4bfli	118	9	E3	e3	NN
cord-265900-7lj4bfli	118	10	activity	activity	NN
cord-265900-7lj4bfli	118	11	or	or	CC
cord-265900-7lj4bfli	118	12	even	even	RB
cord-265900-7lj4bfli	118	13	becoming	become	VBG
cord-265900-7lj4bfli	118	14	part	part	NN
cord-265900-7lj4bfli	118	15	of	of	IN
cord-265900-7lj4bfli	118	16	cellular	cellular	JJ
cord-265900-7lj4bfli	118	17	E3	e3	NN
cord-265900-7lj4bfli	118	18	complex	complex	NN
cord-265900-7lj4bfli	118	19	to	to	TO
cord-265900-7lj4bfli	118	20	degrade	degrade	VB
cord-265900-7lj4bfli	118	21	cellular	cellular	JJ
cord-265900-7lj4bfli	118	22	proteins	protein	NNS
cord-265900-7lj4bfli	118	23	(	(	-LRB-
cord-265900-7lj4bfli	118	24	e.g.	e.g.	JJ
cord-265900-7lj4bfli	118	25	p53	p53	NN
cord-265900-7lj4bfli	118	26	,	,	,
cord-265900-7lj4bfli	118	27	MHC	MHC	NNP
cord-265900-7lj4bfli	118	28	-	-	HYPH
cord-265900-7lj4bfli	118	29	I	I	NNP
cord-265900-7lj4bfli	118	30	,	,	,
cord-265900-7lj4bfli	118	31	SAMHD1	SAMHD1	NNS
cord-265900-7lj4bfli	118	32	,	,	,
cord-265900-7lj4bfli	118	33	ARGONAUTE1	argonaute1	XX
cord-265900-7lj4bfli	118	34	)	)	-RRB-
cord-265900-7lj4bfli	118	35	that	that	WDT
cord-265900-7lj4bfli	118	36	limit	limit	VBP
cord-265900-7lj4bfli	118	37	viral	viral	JJ
cord-265900-7lj4bfli	118	38	growth	growth	NN
cord-265900-7lj4bfli	118	39	(	(	-LRB-
cord-265900-7lj4bfli	118	40	blue	blue	JJ
cord-265900-7lj4bfli	118	41	arrow	arrow	NN
cord-265900-7lj4bfli	118	42	)	)	-RRB-
cord-265900-7lj4bfli	118	43	.	.	.
cord-265900-7lj4bfli	119	1	In	in	IN
cord-265900-7lj4bfli	119	2	others	other	NNS
cord-265900-7lj4bfli	119	3	they	-PRON-	PRP
cord-265900-7lj4bfli	119	4	generate	generate	VBP
cord-265900-7lj4bfli	119	5	proteins	protein	NNS
cord-265900-7lj4bfli	119	6	with	with	IN
cord-265900-7lj4bfli	119	7	de	de	JJ
cord-265900-7lj4bfli	119	8	-	-	JJ
cord-265900-7lj4bfli	119	9	ubiquitinating	ubiquitinating	JJ
cord-265900-7lj4bfli	119	10	or	or	CC
cord-265900-7lj4bfli	119	11	de	de	JJ
cord-265900-7lj4bfli	119	12	-	-	JJ
cord-265900-7lj4bfli	119	13	ubiquitinating	ubiquitinating	JJ
cord-265900-7lj4bfli	119	14	-	-	HYPH
cord-265900-7lj4bfli	119	15	like	like	JJ
cord-265900-7lj4bfli	119	16	activity	activity	NN
cord-265900-7lj4bfli	119	17	to	to	TO
cord-265900-7lj4bfli	119	18	interfere	interfere	VB
cord-265900-7lj4bfli	119	19	with	with	IN
cord-265900-7lj4bfli	119	20	the	the	DT
cord-265900-7lj4bfli	119	21	host	host	NN
cord-265900-7lj4bfli	119	22	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	119	23	or	or	CC
cord-265900-7lj4bfli	119	24	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	119	25	-	-	HYPH
cord-265900-7lj4bfli	119	26	like	like	JJ
cord-265900-7lj4bfli	119	27	(	(	-LRB-
cord-265900-7lj4bfli	119	28	e.g.	e.g.	JJ
cord-265900-7lj4bfli	119	29	SUMO	SUMO	NNP
cord-265900-7lj4bfli	119	30	and	and	CC
cord-265900-7lj4bfli	119	31	ISG15	isg15	NN
cord-265900-7lj4bfli	119	32	)	)	-RRB-
cord-265900-7lj4bfli	119	33	conjugation	conjugation	NN
cord-265900-7lj4bfli	119	34	system	system	NN
cord-265900-7lj4bfli	119	35	to	to	TO
cord-265900-7lj4bfli	119	36	combat	combat	VB
cord-265900-7lj4bfli	119	37	the	the	DT
cord-265900-7lj4bfli	119	38	host	host	NN
cord-265900-7lj4bfli	119	39	anti	anti	JJ
cord-265900-7lj4bfli	119	40	-	-	JJ
cord-265900-7lj4bfli	119	41	viral	viral	JJ
cord-265900-7lj4bfli	119	42	signaling	signal	VBG
cord-265900-7lj4bfli	119	43	pathways	pathway	NNS
cord-265900-7lj4bfli	119	44	(	(	-LRB-
cord-265900-7lj4bfli	119	45	red	red	JJ
cord-265900-7lj4bfli	119	46	lines	line	NNS
cord-265900-7lj4bfli	119	47	)	)	-RRB-
cord-265900-7lj4bfli	119	48	.	.	.
cord-265900-7lj4bfli	120	1	Viral	viral	JJ
cord-265900-7lj4bfli	120	2	protein	protein	NN
cord-265900-7lj4bfli	120	3	modification	modification	NN
cord-265900-7lj4bfli	120	4	by	by	IN
cord-265900-7lj4bfli	120	5	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	120	6	or	or	CC
cord-265900-7lj4bfli	120	7	SUMO	SUMO	NNP
cord-265900-7lj4bfli	120	8	is	be	VBZ
cord-265900-7lj4bfli	120	9	often	often	RB
cord-265900-7lj4bfli	120	10	associated	associate	VBN
cord-265900-7lj4bfli	120	11	with	with	IN
cord-265900-7lj4bfli	120	12	increased	increase	VBN
cord-265900-7lj4bfli	120	13	viral	viral	JJ
cord-265900-7lj4bfli	120	14	release	release	NN
cord-265900-7lj4bfli	120	15	and	and	CC
cord-265900-7lj4bfli	120	16	replication	replication	NN
cord-265900-7lj4bfli	120	17	,	,	,
cord-265900-7lj4bfli	120	18	whereas	whereas	IN
cord-265900-7lj4bfli	120	19	modification	modification	NN
cord-265900-7lj4bfli	120	20	by	by	IN
cord-265900-7lj4bfli	120	21	ISG15	isg15	NN
cord-265900-7lj4bfli	120	22	results	result	NNS
cord-265900-7lj4bfli	120	23	in	in	IN
cord-265900-7lj4bfli	120	24	reduced	reduce	VBN
cord-265900-7lj4bfli	120	25	viral	viral	JJ
cord-265900-7lj4bfli	120	26	protein	protein	NN
cord-265900-7lj4bfli	120	27	function	function	NN
cord-265900-7lj4bfli	120	28	.	.	.
cord-265900-7lj4bfli	121	1	Viral	viral	JJ
cord-265900-7lj4bfli	121	2	protein	protein	NN
cord-265900-7lj4bfli	121	3	degradation	degradation	NN
cord-265900-7lj4bfli	121	4	is	be	VBZ
cord-265900-7lj4bfli	121	5	either	either	CC
cord-265900-7lj4bfli	121	6	a	a	DT
cord-265900-7lj4bfli	121	7	reflection	reflection	NN
cord-265900-7lj4bfli	121	8	of	of	IN
cord-265900-7lj4bfli	121	9	viral	viral	JJ
cord-265900-7lj4bfli	121	10	clearance	clearance	NN
cord-265900-7lj4bfli	121	11	by	by	IN
cord-265900-7lj4bfli	121	12	host	host	NN
cord-265900-7lj4bfli	121	13	immune	immune	JJ
cord-265900-7lj4bfli	121	14	response	response	NN
cord-265900-7lj4bfli	121	15	or	or	CC
cord-265900-7lj4bfli	121	16	a	a	DT
cord-265900-7lj4bfli	121	17	viral	viral	JJ
cord-265900-7lj4bfli	121	18	strategy	strategy	NN
cord-265900-7lj4bfli	121	19	to	to	TO
cord-265900-7lj4bfli	121	20	maintain	maintain	VB
cord-265900-7lj4bfli	121	21	an	an	DT
cord-265900-7lj4bfli	121	22	optimal	optimal	JJ
cord-265900-7lj4bfli	121	23	level	level	NN
cord-265900-7lj4bfli	121	24	of	of	IN
cord-265900-7lj4bfli	121	25	viral	viral	JJ
cord-265900-7lj4bfli	121	26	protein	protein	NN
cord-265900-7lj4bfli	121	27	to	to	TO
cord-265900-7lj4bfli	121	28	ensure	ensure	VB
cord-265900-7lj4bfli	121	29	efficient	efficient	JJ
cord-265900-7lj4bfli	121	30	viral	viral	JJ
cord-265900-7lj4bfli	121	31	production	production	NN
cord-265900-7lj4bfli	121	32	.	.	.
cord-265900-7lj4bfli	122	1	Abbreviations	abbreviation	NNS
cord-265900-7lj4bfli	122	2	:	:	:
cord-265900-7lj4bfli	122	3	E1	E1	NNP
cord-265900-7lj4bfli	122	4	,	,	,
cord-265900-7lj4bfli	122	5	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	122	6	/	/	SYM
cord-265900-7lj4bfli	122	7	SUMO	SUMO	NNP
cord-265900-7lj4bfli	122	8	/	/	SYM
cord-265900-7lj4bfli	122	9	ISG15-activating	isg15-activating	NN
cord-265900-7lj4bfli	122	10	enzyme	enzyme	NN
cord-265900-7lj4bfli	122	11	;	;	:
cord-265900-7lj4bfli	122	12	E2	E2	NNP
cord-265900-7lj4bfli	122	13	,	,	,
cord-265900-7lj4bfli	122	14	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	122	15	/	/	SYM
cord-265900-7lj4bfli	122	16	SUMO	SUMO	NNP
cord-265900-7lj4bfli	122	17	/	/	SYM
cord-265900-7lj4bfli	122	18	ISG15-conjugating	isg15-conjugating	NN
cord-265900-7lj4bfli	122	19	enzyme	enzyme	NN
cord-265900-7lj4bfli	122	20	;	;	:
cord-265900-7lj4bfli	122	21	E3	E3	NNP
cord-265900-7lj4bfli	122	22	,	,	,
cord-265900-7lj4bfli	122	23	ubiquitin	ubiquitin	NNP
cord-265900-7lj4bfli	122	24	/	/	SYM
cord-265900-7lj4bfli	122	25	SUMO/	SUMO/	NNP
cord-265900-7lj4bfli	122	26	ISG15	isg15	NN
cord-265900-7lj4bfli	122	27	ligase	ligase	NN
cord-265900-7lj4bfli	122	28	;	;	.
cord-265900-7lj4bfli	123	1	ISG15	ISG15	NNP
cord-265900-7lj4bfli	123	2	,	,	,
cord-265900-7lj4bfli	123	3	interferon	interferon	NN
cord-265900-7lj4bfli	123	4	-	-	HYPH
cord-265900-7lj4bfli	123	5	stimulated	stimulate	VBN
cord-265900-7lj4bfli	123	6	gene	gene	NN
cord-265900-7lj4bfli	123	7	15	15	CD
cord-265900-7lj4bfli	123	8	;	;	:
cord-265900-7lj4bfli	123	9	MHC	MHC	NNP
cord-265900-7lj4bfli	123	10	-	-	HYPH
cord-265900-7lj4bfli	123	11	I	I	NNP
cord-265900-7lj4bfli	123	12	,	,	,
cord-265900-7lj4bfli	123	13	major	major	JJ
cord-265900-7lj4bfli	123	14	histocompatibility	histocompatibility	NN
cord-265900-7lj4bfli	123	15	;	;	:
cord-265900-7lj4bfli	123	16	SAMHD1	SAMHD1	NNS
cord-265900-7lj4bfli	123	17	,	,	,
cord-265900-7lj4bfli	123	18	sterile	sterile	JJ
cord-265900-7lj4bfli	123	19	alpha	alpha	NN
cord-265900-7lj4bfli	123	20	motif	motif	NN
cord-265900-7lj4bfli	123	21	domain	domain	NN
cord-265900-7lj4bfli	123	22	-	-	HYPH
cord-265900-7lj4bfli	123	23	containing	contain	VBG
cord-265900-7lj4bfli	123	24	protein	protein	NN
cord-265900-7lj4bfli	123	25	1	1	CD
cord-265900-7lj4bfli	123	26	and	and	CC
cord-265900-7lj4bfli	123	27	histidine	histidine	NN
cord-265900-7lj4bfli	123	28	-	-	HYPH
cord-265900-7lj4bfli	123	29	aspartate	aspartate	NN
cord-265900-7lj4bfli	123	30	domain	domain	NN
cord-265900-7lj4bfli	123	31	-	-	HYPH
cord-265900-7lj4bfli	123	32	containing	contain	VBG
cord-265900-7lj4bfli	123	33	protein	protein	NN
cord-265900-7lj4bfli	123	34	1	1	CD
cord-265900-7lj4bfli	123	35	;	;	:
cord-265900-7lj4bfli	123	36	INFa	INFa	NNP
cord-265900-7lj4bfli	123	37	/	/	SYM
cord-265900-7lj4bfli	123	38	b	b	NN
cord-265900-7lj4bfli	123	39	,	,	,
cord-265900-7lj4bfli	123	40	interferon	interferon	NN
cord-265900-7lj4bfli	123	41	-	-	HYPH
cord-265900-7lj4bfli	123	42	a	a	NN
cord-265900-7lj4bfli	123	43	/	/	SYM
cord-265900-7lj4bfli	123	44	b	b	NN
cord-265900-7lj4bfli	123	45	.	.	.
cord-265900-7lj4bfli	124	1	Viral	viral	JJ
cord-265900-7lj4bfli	124	2	interaction	interaction	NN
cord-265900-7lj4bfli	124	3	with	with	IN
cord-265900-7lj4bfli	124	4	the	the	DT
cord-265900-7lj4bfli	124	5	host	host	NN
cord-265900-7lj4bfli	124	6	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	124	7	-	-	HYPH
cord-265900-7lj4bfli	124	8	proteasome	proteasome	NN
cord-265900-7lj4bfli	124	9	system	system	NN
cord-265900-7lj4bfli	124	10	Luo	Luo	NNP
cord-265900-7lj4bfli	124	11	5	5	CD
cord-265900-7lj4bfli	124	12	Table	table	NN
cord-265900-7lj4bfli	124	13	1	1	CD
cord-265900-7lj4bfli	124	14	Interplay	interplay	NN
cord-265900-7lj4bfli	124	15	between	between	IN
cord-265900-7lj4bfli	124	16	the	the	DT
cord-265900-7lj4bfli	124	17	viruses	virus	NNS
cord-265900-7lj4bfli	124	18	and	and	CC
cord-265900-7lj4bfli	124	19	the	the	DT
cord-265900-7lj4bfli	124	20	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	124	21	-	-	HYPH
cord-265900-7lj4bfli	124	22	proteasome	proteasome	VBN
cord-265900-7lj4bfli	124	23	system	system	NN
cord-265900-7lj4bfli	124	24	[	[	-LRB-
cord-265900-7lj4bfli	124	25	77	77	CD
cord-265900-7lj4bfli	124	26	]	]	-RRB-
cord-265900-7lj4bfli	124	27	.	.	.
cord-265900-7lj4bfli	125	1	Expression	expression	NN
cord-265900-7lj4bfli	125	2	of	of	IN
cord-265900-7lj4bfli	125	3	ISG15	isg15	NN
cord-265900-7lj4bfli	125	4	is	be	VBZ
cord-265900-7lj4bfli	125	5	highly	highly	RB
cord-265900-7lj4bfli	125	6	inducible	inducible	JJ
cord-265900-7lj4bfli	125	7	by	by	IN
cord-265900-7lj4bfli	125	8	type	type	NN
cord-265900-7lj4bfli	126	1	I	-PRON-	PRP
cord-265900-7lj4bfli	126	2	IFN	IFN	NNP
cord-265900-7lj4bfli	126	3	upon	upon	IN
cord-265900-7lj4bfli	126	4	viral	viral	JJ
cord-265900-7lj4bfli	126	5	infection	infection	NN
cord-265900-7lj4bfli	126	6	[	[	-LRB-
cord-265900-7lj4bfli	126	7	7	7	CD
cord-265900-7lj4bfli	126	8	]	]	-RRB-
cord-265900-7lj4bfli	126	9	.	.	.
cord-265900-7lj4bfli	127	1	Animal	animal	NN
cord-265900-7lj4bfli	127	2	studies	study	NNS
cord-265900-7lj4bfli	127	3	have	have	VBP
cord-265900-7lj4bfli	127	4	shown	show	VBN
cord-265900-7lj4bfli	127	5	that	that	IN
cord-265900-7lj4bfli	127	6	mice	mouse	NNS
cord-265900-7lj4bfli	127	7	with	with	IN
cord-265900-7lj4bfli	127	8	ISG15	ISG15	NNP
cord-265900-7lj4bfli	127	9	À	à	NN
cord-265900-7lj4bfli	127	10	/	/	SYM
cord-265900-7lj4bfli	127	11	À	à	NN
cord-265900-7lj4bfli	127	12	or	or	CC
cord-265900-7lj4bfli	127	13	UBE1L	ube1l	IN
cord-265900-7lj4bfli	127	14	À	à	NN
cord-265900-7lj4bfli	127	15	/	/	SYM
cord-265900-7lj4bfli	127	16	À	à	NN
cord-265900-7lj4bfli	127	17	(	(	-LRB-
cord-265900-7lj4bfli	127	18	which	which	WDT
cord-265900-7lj4bfli	127	19	lack	lack	VBP
cord-265900-7lj4bfli	127	20	the	the	DT
cord-265900-7lj4bfli	127	21	ISG15	isg15	NN
cord-265900-7lj4bfli	127	22	conjugating	conjugate	VBG
cord-265900-7lj4bfli	127	23	enzyme	enzyme	NN
cord-265900-7lj4bfli	127	24	)	)	-RRB-
cord-265900-7lj4bfli	127	25	are	be	VBP
cord-265900-7lj4bfli	127	26	more	more	RBR
cord-265900-7lj4bfli	127	27	susceptible	susceptible	JJ
cord-265900-7lj4bfli	127	28	to	to	IN
cord-265900-7lj4bfli	127	29	various	various	JJ
cord-265900-7lj4bfli	127	30	viral	viral	JJ
cord-265900-7lj4bfli	127	31	infections	infection	NNS
cord-265900-7lj4bfli	127	32	and	and	CC
cord-265900-7lj4bfli	127	33	develop	develop	VB
cord-265900-7lj4bfli	127	34	more	more	RBR
cord-265900-7lj4bfli	127	35	severe	severe	JJ
cord-265900-7lj4bfli	127	36	tissue	tissue	NN
cord-265900-7lj4bfli	127	37	damage	damage	NN
cord-265900-7lj4bfli	127	38	[	[	-LRB-
cord-265900-7lj4bfli	127	39	78	78	CD
cord-265900-7lj4bfli	127	40	]	]	-RRB-
cord-265900-7lj4bfli	128	1	[	[	-LRB-
cord-265900-7lj4bfli	128	2	79	79	CD
cord-265900-7lj4bfli	128	3	]	]	-RRB-
cord-265900-7lj4bfli	128	4	[	[	-LRB-
cord-265900-7lj4bfli	128	5	80	80	CD
cord-265900-7lj4bfli	128	6	]	]	-RRB-
cord-265900-7lj4bfli	128	7	.	.	.
cord-265900-7lj4bfli	129	1	The	the	DT
cord-265900-7lj4bfli	129	2	mechanism	mechanism	NN
cord-265900-7lj4bfli	129	3	of	of	IN
cord-265900-7lj4bfli	129	4	the	the	DT
cord-265900-7lj4bfli	129	5	anti	anti	JJ
cord-265900-7lj4bfli	129	6	-	-	JJ
cord-265900-7lj4bfli	129	7	viral	viral	JJ
cord-265900-7lj4bfli	129	8	property	property	NN
cord-265900-7lj4bfli	129	9	of	of	IN
cord-265900-7lj4bfli	129	10	ISG15	ISG15	NNP
cord-265900-7lj4bfli	129	11	remains	remain	VBZ
cord-265900-7lj4bfli	129	12	largely	largely	RB
cord-265900-7lj4bfli	129	13	unclear	unclear	JJ
cord-265900-7lj4bfli	129	14	.	.	.
cord-265900-7lj4bfli	130	1	Recent	recent	JJ
cord-265900-7lj4bfli	130	2	studies	study	NNS
cord-265900-7lj4bfli	130	3	suggest	suggest	VBP
cord-265900-7lj4bfli	130	4	that	that	IN
cord-265900-7lj4bfli	130	5	it	-PRON-	PRP
cord-265900-7lj4bfli	130	6	involves	involve	VBZ
cord-265900-7lj4bfli	130	7	the	the	DT
cord-265900-7lj4bfli	130	8	protective	protective	JJ
cord-265900-7lj4bfli	130	9	function	function	NN
cord-265900-7lj4bfli	130	10	of	of	IN
cord-265900-7lj4bfli	130	11	unconjugated	unconjugated	JJ
cord-265900-7lj4bfli	130	12	ISG15	isg15	NN
cord-265900-7lj4bfli	130	13	against	against	IN
cord-265900-7lj4bfli	130	14	viral	viral	JJ
cord-265900-7lj4bfli	130	15	infection	infection	NN
cord-265900-7lj4bfli	130	16	and	and	CC
cord-265900-7lj4bfli	130	17	posttranslational	posttranslational	JJ
cord-265900-7lj4bfli	130	18	modification	modification	NN
cord-265900-7lj4bfli	130	19	of	of	IN
cord-265900-7lj4bfli	130	20	both	both	DT
cord-265900-7lj4bfli	130	21	host	host	NN
cord-265900-7lj4bfli	130	22	and	and	CC
cord-265900-7lj4bfli	130	23	viral	viral	JJ
cord-265900-7lj4bfli	130	24	proteins	protein	NNS
cord-265900-7lj4bfli	130	25	[	[	-LRB-
cord-265900-7lj4bfli	130	26	77	77	CD
cord-265900-7lj4bfli	130	27	]	]	-RRB-
cord-265900-7lj4bfli	130	28	.	.	.
cord-265900-7lj4bfli	131	1	It	-PRON-	PRP
cord-265900-7lj4bfli	131	2	has	have	VBZ
cord-265900-7lj4bfli	131	3	been	be	VBN
cord-265900-7lj4bfli	131	4	shown	show	VBN
cord-265900-7lj4bfli	131	5	that	that	DT
cord-265900-7lj4bfli	131	6	expression	expression	NN
cord-265900-7lj4bfli	131	7	of	of	IN
cord-265900-7lj4bfli	131	8	ISG15	isg15	NN
cord-265900-7lj4bfli	131	9	blocks	block	VBZ
cord-265900-7lj4bfli	131	10	the	the	DT
cord-265900-7lj4bfli	131	11	activity	activity	NN
cord-265900-7lj4bfli	131	12	of	of	IN
cord-265900-7lj4bfli	131	13	Nedd4	Nedd4	NNP
cord-265900-7lj4bfli	131	14	,	,	,
cord-265900-7lj4bfli	131	15	thereby	thereby	RB
cord-265900-7lj4bfli	131	16	inhibiting	inhibit	VBG
cord-265900-7lj4bfli	131	17	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	131	18	of	of	IN
cord-265900-7lj4bfli	131	19	HIV-1	HIV-1	NNP
cord-265900-7lj4bfli	131	20	Gag	Gag	NNP
cord-265900-7lj4bfli	131	21	and	and	CC
cord-265900-7lj4bfli	131	22	Tsg101	tsg101	DT
cord-265900-7lj4bfli	131	23	proteins	protein	NNS
cord-265900-7lj4bfli	131	24	and	and	CC
cord-265900-7lj4bfli	131	25	Ebola	Ebola	NNP
cord-265900-7lj4bfli	131	26	viral	viral	JJ
cord-265900-7lj4bfli	131	27	matrix	matrix	NN
cord-265900-7lj4bfli	131	28	proteins	protein	NNS
cord-265900-7lj4bfli	131	29	(	(	-LRB-
cord-265900-7lj4bfli	131	30	VP40	VP40	NNP
cord-265900-7lj4bfli	131	31	)	)	-RRB-
cord-265900-7lj4bfli	131	32	,	,	,
cord-265900-7lj4bfli	131	33	which	which	WDT
cord-265900-7lj4bfli	131	34	are	be	VBP
cord-265900-7lj4bfli	131	35	necessary	necessary	JJ
cord-265900-7lj4bfli	131	36	for	for	IN
cord-265900-7lj4bfli	131	37	viral	viral	JJ
cord-265900-7lj4bfli	131	38	budding/	budding/	CD
cord-265900-7lj4bfli	131	39	release	release	NN
cord-265900-7lj4bfli	131	40	[	[	-LRB-
cord-265900-7lj4bfli	131	41	81	81	CD
cord-265900-7lj4bfli	131	42	,	,	,
cord-265900-7lj4bfli	131	43	82	82	CD
cord-265900-7lj4bfli	131	44	]	]	-RRB-
cord-265900-7lj4bfli	131	45	.	.	.
cord-265900-7lj4bfli	132	1	Moreover	moreover	RB
cord-265900-7lj4bfli	132	2	,	,	,
cord-265900-7lj4bfli	132	3	viral	viral	JJ
cord-265900-7lj4bfli	132	4	protein	protein	NN
cord-265900-7lj4bfli	132	5	ISGylation	ISGylation	NNP
cord-265900-7lj4bfli	132	6	has	have	VBZ
cord-265900-7lj4bfli	132	7	been	be	VBN
cord-265900-7lj4bfli	132	8	revealed	reveal	VBN
cord-265900-7lj4bfli	132	9	to	to	TO
cord-265900-7lj4bfli	132	10	also	also	RB
cord-265900-7lj4bfli	132	11	contribute	contribute	VB
cord-265900-7lj4bfli	132	12	to	to	IN
cord-265900-7lj4bfli	132	13	the	the	DT
cord-265900-7lj4bfli	132	14	type	type	NN
cord-265900-7lj4bfli	132	15	I	-PRON-	PRP
cord-265900-7lj4bfli	132	16	IFN	IFN	NNP
cord-265900-7lj4bfli	132	17	-	-	HYPH
cord-265900-7lj4bfli	132	18	mediated	mediate	VBN
cord-265900-7lj4bfli	132	19	anti	anti	JJ
cord-265900-7lj4bfli	132	20	-	-	JJ
cord-265900-7lj4bfli	132	21	viral	viral	JJ
cord-265900-7lj4bfli	132	22	response	response	NN
cord-265900-7lj4bfli	132	23	.	.	.
cord-265900-7lj4bfli	133	1	Although	although	IN
cord-265900-7lj4bfli	133	2	the	the	DT
cord-265900-7lj4bfli	133	3	precise	precise	JJ
cord-265900-7lj4bfli	133	4	mechanisms	mechanism	NNS
cord-265900-7lj4bfli	133	5	remain	remain	VBP
cord-265900-7lj4bfli	133	6	to	to	TO
cord-265900-7lj4bfli	133	7	be	be	VB
cord-265900-7lj4bfli	133	8	established	establish	VBN
cord-265900-7lj4bfli	133	9	,	,	,
cord-265900-7lj4bfli	133	10	available	available	JJ
cord-265900-7lj4bfli	133	11	evidence	evidence	NN
cord-265900-7lj4bfli	133	12	supports	support	VBZ
cord-265900-7lj4bfli	133	13	a	a	DT
cord-265900-7lj4bfli	133	14	loss	loss	NN
cord-265900-7lj4bfli	133	15	-	-	HYPH
cord-265900-7lj4bfli	133	16	of	of	IN
cord-265900-7lj4bfli	133	17	-	-	HYPH
cord-265900-7lj4bfli	133	18	function	function	NN
cord-265900-7lj4bfli	133	19	mechanism	mechanism	NN
cord-265900-7lj4bfli	133	20	of	of	IN
cord-265900-7lj4bfli	133	21	ISG15	isg15	NN
cord-265900-7lj4bfli	133	22	modified	modify	VBN
cord-265900-7lj4bfli	133	23	viral	viral	JJ
cord-265900-7lj4bfli	133	24	proteins	protein	NNS
cord-265900-7lj4bfli	133	25	.	.	.
cord-265900-7lj4bfli	134	1	It	-PRON-	PRP
cord-265900-7lj4bfli	134	2	was	be	VBD
cord-265900-7lj4bfli	134	3	reported	report	VBN
cord-265900-7lj4bfli	134	4	that	that	IN
cord-265900-7lj4bfli	134	5	ISGylation	isgylation	NN
cord-265900-7lj4bfli	134	6	of	of	IN
cord-265900-7lj4bfli	134	7	the	the	DT
cord-265900-7lj4bfli	134	8	influenza	influenza	NN
cord-265900-7lj4bfli	134	9	A	a	DT
cord-265900-7lj4bfli	134	10	virus	virus	NN
cord-265900-7lj4bfli	134	11	NS1	ns1	CD
cord-265900-7lj4bfli	134	12	protein	protein	NN
cord-265900-7lj4bfli	134	13	via	via	IN
cord-265900-7lj4bfli	134	14	the	the	DT
cord-265900-7lj4bfli	134	15	function	function	NN
cord-265900-7lj4bfli	134	16	of	of	IN
cord-265900-7lj4bfli	134	17	the	the	DT
cord-265900-7lj4bfli	134	18	E3	e3	NN
cord-265900-7lj4bfli	134	19	ligase	ligase	NN
cord-265900-7lj4bfli	134	20	UERC5	uerc5	JJ
cord-265900-7lj4bfli	134	21	results	result	NNS
cord-265900-7lj4bfli	134	22	in	in	IN
cord-265900-7lj4bfli	134	23	impaired	impair	VBN
cord-265900-7lj4bfli	134	24	viral	viral	JJ
cord-265900-7lj4bfli	134	25	replication	replication	NN
cord-265900-7lj4bfli	134	26	[	[	-LRB-
cord-265900-7lj4bfli	134	27	83	83	CD
cord-265900-7lj4bfli	134	28	]	]	-RRB-
cord-265900-7lj4bfli	134	29	.	.	.
cord-265900-7lj4bfli	135	1	Similarly	similarly	RB
cord-265900-7lj4bfli	135	2	,	,	,
cord-265900-7lj4bfli	135	3	modification	modification	NN
cord-265900-7lj4bfli	135	4	of	of	IN
cord-265900-7lj4bfli	135	5	the	the	DT
cord-265900-7lj4bfli	135	6	HPV	HPV	NNP
cord-265900-7lj4bfli	135	7	L1	L1	NNP
cord-265900-7lj4bfli	135	8	capsid	capsid	NN
cord-265900-7lj4bfli	135	9	protein	protein	NN
cord-265900-7lj4bfli	135	10	by	by	IN
cord-265900-7lj4bfli	135	11	ISG15	ISG15	NNP
cord-265900-7lj4bfli	135	12	is	be	VBZ
cord-265900-7lj4bfli	135	13	linked	link	VBN
cord-265900-7lj4bfli	135	14	to	to	IN
cord-265900-7lj4bfli	135	15	decreased	decrease	VBN
cord-265900-7lj4bfli	135	16	viral	viral	JJ
cord-265900-7lj4bfli	135	17	production	production	NN
cord-265900-7lj4bfli	135	18	[	[	-LRB-
cord-265900-7lj4bfli	135	19	84	84	CD
cord-265900-7lj4bfli	135	20	]	]	-RRB-
cord-265900-7lj4bfli	135	21	.	.	.
cord-265900-7lj4bfli	136	1	In	in	IN
cord-265900-7lj4bfli	136	2	coxsackievirus	coxsackievirus	NNP
cord-265900-7lj4bfli	136	3	infection	infection	NN
cord-265900-7lj4bfli	136	4	,	,	,
cord-265900-7lj4bfli	136	5	it	-PRON-	PRP
cord-265900-7lj4bfli	136	6	was	be	VBD
cord-265900-7lj4bfli	136	7	found	find	VBN
cord-265900-7lj4bfli	136	8	that	that	IN
cord-265900-7lj4bfli	136	9	ISG15	ISG15	NNP
cord-265900-7lj4bfli	136	10	modification	modification	NN
cord-265900-7lj4bfli	136	11	of	of	IN
cord-265900-7lj4bfli	136	12	2A	2a	CD
cord-265900-7lj4bfli	136	13	protease	protease	NN
cord-265900-7lj4bfli	136	14	attenuates	attenuate	VBZ
cord-265900-7lj4bfli	136	15	its	-PRON-	PRP$
cord-265900-7lj4bfli	136	16	activity	activity	NN
cord-265900-7lj4bfli	136	17	in	in	IN
cord-265900-7lj4bfli	136	18	cleaving	cleave	VBG
cord-265900-7lj4bfli	136	19	host	host	NN
cord-265900-7lj4bfli	136	20	eukaryotic	eukaryotic	JJ
cord-265900-7lj4bfli	136	21	translation	translation	NN
cord-265900-7lj4bfli	136	22	initiation	initiation	NN
cord-265900-7lj4bfli	136	23	factor	factor	NN
cord-265900-7lj4bfli	136	24	4	4	CD
cord-265900-7lj4bfli	136	25	G	g	NN
cord-265900-7lj4bfli	136	26	,	,	,
cord-265900-7lj4bfli	136	27	thereby	thereby	RB
cord-265900-7lj4bfli	136	28	counteracting	counteract	VBG
cord-265900-7lj4bfli	136	29	host	host	NN
cord-265900-7lj4bfli	136	30	translation	translation	NN
cord-265900-7lj4bfli	136	31	shutoff	shutoff	NN
cord-265900-7lj4bfli	136	32	during	during	IN
cord-265900-7lj4bfli	136	33	viral	viral	JJ
cord-265900-7lj4bfli	136	34	infection	infection	NN
cord-265900-7lj4bfli	136	35	[	[	-LRB-
cord-265900-7lj4bfli	136	36	85	85	CD
cord-265900-7lj4bfli	136	37	]	]	-RRB-
cord-265900-7lj4bfli	136	38	.	.	.
cord-265900-7lj4bfli	137	1	In	in	IN
cord-265900-7lj4bfli	137	2	addition	addition	NN
cord-265900-7lj4bfli	137	3	to	to	IN
cord-265900-7lj4bfli	137	4	their	-PRON-	PRP$
cord-265900-7lj4bfli	137	5	role	role	NN
cord-265900-7lj4bfli	137	6	in	in	IN
cord-265900-7lj4bfli	137	7	regulating	regulate	VBG
cord-265900-7lj4bfli	137	8	viral	viral	JJ
cord-265900-7lj4bfli	137	9	protein	protein	NN
cord-265900-7lj4bfli	137	10	function	function	NN
cord-265900-7lj4bfli	137	11	,	,	,
cord-265900-7lj4bfli	137	12	modification	modification	NN
cord-265900-7lj4bfli	137	13	by	by	IN
cord-265900-7lj4bfli	137	14	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	137	15	and	and	CC
cord-265900-7lj4bfli	137	16	sumoylation	sumoylation	NN
cord-265900-7lj4bfli	137	17	has	have	VBZ
cord-265900-7lj4bfli	137	18	emerged	emerge	VBN
cord-265900-7lj4bfli	137	19	as	as	IN
cord-265900-7lj4bfli	137	20	a	a	DT
cord-265900-7lj4bfli	137	21	central	central	JJ
cord-265900-7lj4bfli	137	22	host	host	NN
cord-265900-7lj4bfli	137	23	anti	anti	JJ
cord-265900-7lj4bfli	137	24	-	-	JJ
cord-265900-7lj4bfli	137	25	viral	viral	JJ
cord-265900-7lj4bfli	137	26	mechanism	mechanism	NN
cord-265900-7lj4bfli	137	27	through	through	IN
cord-265900-7lj4bfli	137	28	modulating	modulate	VBG
cord-265900-7lj4bfli	137	29	the	the	DT
cord-265900-7lj4bfli	137	30	function	function	NN
cord-265900-7lj4bfli	137	31	of	of	IN
cord-265900-7lj4bfli	137	32	key	key	JJ
cord-265900-7lj4bfli	137	33	signaling	signal	VBG
cord-265900-7lj4bfli	137	34	molecules	molecule	NNS
cord-265900-7lj4bfli	137	35	involved	involve	VBN
cord-265900-7lj4bfli	137	36	in	in	IN
cord-265900-7lj4bfli	137	37	innate	innate	JJ
cord-265900-7lj4bfli	137	38	immunity	immunity	NN
cord-265900-7lj4bfli	137	39	,	,	,
cord-265900-7lj4bfli	137	40	such	such	PDT
cord-265900-7lj4bfli	137	41	the	the	DT
cord-265900-7lj4bfli	137	42	pattern	pattern	NN
cord-265900-7lj4bfli	137	43	recognition	recognition	NN
cord-265900-7lj4bfli	137	44	receptor	receptor	NN
cord-265900-7lj4bfli	137	45	signaling	signal	VBG
cord-265900-7lj4bfli	137	46	pathway	pathway	NN
cord-265900-7lj4bfli	137	47	and	and	CC
cord-265900-7lj4bfli	137	48	the	the	DT
cord-265900-7lj4bfli	137	49	NFkB	NFkB	NNP
cord-265900-7lj4bfli	137	50	pathway	pathway	NN
cord-265900-7lj4bfli	137	51	(	(	-LRB-
cord-265900-7lj4bfli	137	52	see	see	VB
cord-265900-7lj4bfli	137	53	reviews	review	NNS
cord-265900-7lj4bfli	137	54	[	[	-LRB-
cord-265900-7lj4bfli	137	55	86,87	86,87	CD
cord-265900-7lj4bfli	137	56	,	,	,
cord-265900-7lj4bfli	137	57	88	88	CD
cord-265900-7lj4bfli	137	58	]	]	-RRB-
cord-265900-7lj4bfli	137	59	for	for	IN
cord-265900-7lj4bfli	137	60	the	the	DT
cord-265900-7lj4bfli	137	61	details	detail	NNS
cord-265900-7lj4bfli	137	62	)	)	-RRB-
cord-265900-7lj4bfli	137	63	.	.	.
cord-265900-7lj4bfli	138	1	There	there	EX
cord-265900-7lj4bfli	138	2	is	be	VBZ
cord-265900-7lj4bfli	138	3	increasing	increase	VBG
cord-265900-7lj4bfli	138	4	evidence	evidence	NN
cord-265900-7lj4bfli	138	5	that	that	IN
cord-265900-7lj4bfli	138	6	viruses	virus	NNS
cord-265900-7lj4bfli	138	7	have	have	VBP
cord-265900-7lj4bfli	138	8	evolved	evolve	VBN
cord-265900-7lj4bfli	138	9	strategies	strategy	NNS
cord-265900-7lj4bfli	138	10	to	to	TO
cord-265900-7lj4bfli	138	11	block	block	VB
cord-265900-7lj4bfli	138	12	these	these	DT
cord-265900-7lj4bfli	138	13	processes	process	NNS
cord-265900-7lj4bfli	138	14	to	to	TO
cord-265900-7lj4bfli	138	15	evade	evade	VB
cord-265900-7lj4bfli	138	16	host	host	NN
cord-265900-7lj4bfli	138	17	innate	innate	JJ
cord-265900-7lj4bfli	138	18	immune	immune	JJ
cord-265900-7lj4bfli	138	19	responses	response	NNS
cord-265900-7lj4bfli	138	20	.	.	.
cord-265900-7lj4bfli	139	1	For	for	IN
cord-265900-7lj4bfli	139	2	example	example	NN
cord-265900-7lj4bfli	139	3	,	,	,
cord-265900-7lj4bfli	139	4	herpes	herpes	NNP
cord-265900-7lj4bfli	139	5	simplex	simplex	NNP
cord-265900-7lj4bfli	139	6	virus	virus	NN
cord-265900-7lj4bfli	139	7	1	1	CD
cord-265900-7lj4bfli	139	8	encodes	encode	VBZ
cord-265900-7lj4bfli	139	9	the	the	DT
cord-265900-7lj4bfli	139	10	largest	large	JJS
cord-265900-7lj4bfli	139	11	tegument	tegument	NN
cord-265900-7lj4bfli	139	12	protein	protein	NN
cord-265900-7lj4bfli	139	13	,	,	,
cord-265900-7lj4bfli	139	14	UL36	UL36	NNP
cord-265900-7lj4bfli	139	15	,	,	,
cord-265900-7lj4bfli	139	16	which	which	WDT
cord-265900-7lj4bfli	139	17	acts	act	VBZ
cord-265900-7lj4bfli	139	18	as	as	IN
cord-265900-7lj4bfli	139	19	a	a	DT
cord-265900-7lj4bfli	139	20	DUB	dub	NN
cord-265900-7lj4bfli	139	21	to	to	TO
cord-265900-7lj4bfli	139	22	remove	remove	VB
cord-265900-7lj4bfli	139	23	ubiquitin	ubiquitin	JJ
cord-265900-7lj4bfli	139	24	chains	chain	NNS
cord-265900-7lj4bfli	139	25	from	from	IN
cord-265900-7lj4bfli	139	26	TNF	TNF	NNP
cord-265900-7lj4bfli	139	27	receptor	receptor	NN
cord-265900-7lj4bfli	139	28	associated	associate	VBD
cord-265900-7lj4bfli	139	29	factor	factor	NN
cord-265900-7lj4bfli	139	30	3	3	CD
cord-265900-7lj4bfli	139	31	(	(	-LRB-
cord-265900-7lj4bfli	139	32	TRAF3	TRAF3	NNP
cord-265900-7lj4bfli	139	33	)	)	-RRB-
cord-265900-7lj4bfli	139	34	and	and	CC
cord-265900-7lj4bfli	139	35	consequently	consequently	RB
cord-265900-7lj4bfli	139	36	inhibits	inhibit	VBZ
cord-265900-7lj4bfli	139	37	IFN	IFN	NNP
cord-265900-7lj4bfli	139	38	-	-	HYPH
cord-265900-7lj4bfli	139	39	b	b	NN
cord-265900-7lj4bfli	139	40	signaling	signal	VBG
cord-265900-7lj4bfli	139	41	[	[	-LRB-
cord-265900-7lj4bfli	139	42	89	89	CD
cord-265900-7lj4bfli	139	43	]	]	-RRB-
cord-265900-7lj4bfli	139	44	.	.	.
cord-265900-7lj4bfli	140	1	Similarly	similarly	RB
cord-265900-7lj4bfli	140	2	,	,	,
cord-265900-7lj4bfli	140	3	the	the	DT
cord-265900-7lj4bfli	140	4	ORF64	ORF64	NNP
cord-265900-7lj4bfli	140	5	protein	protein	NN
cord-265900-7lj4bfli	140	6	encoded	encode	VBN
cord-265900-7lj4bfli	140	7	by	by	IN
cord-265900-7lj4bfli	140	8	Kaposi	Kaposi	NNP
cord-265900-7lj4bfli	140	9	's	's	POS
cord-265900-7lj4bfli	140	10	sarcoma	sarcoma	NN
cord-265900-7lj4bfli	140	11	-	-	HYPH
cord-265900-7lj4bfli	140	12	associated	associate	VBN
cord-265900-7lj4bfli	140	13	herpesvirus	herpesvirus	NN
cord-265900-7lj4bfli	140	14	hydrolyzes	hydrolyze	VBZ
cord-265900-7lj4bfli	140	15	ubiquitin	ubiquitin	VBG
cord-265900-7lj4bfli	140	16	chains	chain	NNS
cord-265900-7lj4bfli	140	17	from	from	IN
cord-265900-7lj4bfli	140	18	retinoic	retinoic	JJ
cord-265900-7lj4bfli	140	19	acid	acid	NN
cord-265900-7lj4bfli	140	20	inducible	inducible	JJ
cord-265900-7lj4bfli	140	21	gene	gene	NN
cord-265900-7lj4bfli	140	22	1	1	CD
cord-265900-7lj4bfli	141	1	(	(	-LRB-
cord-265900-7lj4bfli	141	2	RIG	rig	NN
cord-265900-7lj4bfli	141	3	-	-	HYPH
cord-265900-7lj4bfli	141	4	I	I	NNP
cord-265900-7lj4bfli	141	5	)	)	-RRB-
cord-265900-7lj4bfli	141	6	,	,	,
cord-265900-7lj4bfli	141	7	resulting	result	VBG
cord-265900-7lj4bfli	141	8	in	in	IN
cord-265900-7lj4bfli	141	9	decreased	decreased	JJ
cord-265900-7lj4bfli	141	10	production	production	NN
cord-265900-7lj4bfli	141	11	of	of	IN
cord-265900-7lj4bfli	141	12	IFN	IFN	NNP
cord-265900-7lj4bfli	141	13	[	[	-LRB-
cord-265900-7lj4bfli	141	14	90	90	CD
cord-265900-7lj4bfli	141	15	]	]	-RRB-
cord-265900-7lj4bfli	141	16	.	.	.
cord-265900-7lj4bfli	142	1	Besides	besides	IN
cord-265900-7lj4bfli	142	2	viral	viral	JJ
cord-265900-7lj4bfli	142	3	proteins	protein	NNS
cord-265900-7lj4bfli	142	4	,	,	,
cord-265900-7lj4bfli	142	5	a	a	DT
cord-265900-7lj4bfli	142	6	number	number	NN
cord-265900-7lj4bfli	142	7	of	of	IN
cord-265900-7lj4bfli	142	8	anti	anti	JJ
cord-265900-7lj4bfli	142	9	-	-	JJ
cord-265900-7lj4bfli	142	10	viral	viral	JJ
cord-265900-7lj4bfli	142	11	host	host	NN
cord-265900-7lj4bfli	142	12	proteins	protein	NNS
cord-265900-7lj4bfli	142	13	,	,	,
cord-265900-7lj4bfli	142	14	such	such	JJ
cord-265900-7lj4bfli	142	15	as	as	IN
cord-265900-7lj4bfli	142	16	interferon	interferon	NN
cord-265900-7lj4bfli	142	17	regulatory	regulatory	JJ
cord-265900-7lj4bfli	142	18	factor	factor	NN
cord-265900-7lj4bfli	142	19	3	3	CD
cord-265900-7lj4bfli	142	20	[	[	-LRB-
cord-265900-7lj4bfli	142	21	91	91	CD
cord-265900-7lj4bfli	142	22	]	]	-RRB-
cord-265900-7lj4bfli	142	23	,	,	,
cord-265900-7lj4bfli	142	24	RIG	rig	NN
cord-265900-7lj4bfli	142	25	-	-	:
cord-265900-7lj4bfli	142	26	I	i	NN
cord-265900-7lj4bfli	142	27	[	[	-LRB-
cord-265900-7lj4bfli	142	28	92	92	CD
cord-265900-7lj4bfli	142	29	]	]	-RRB-
cord-265900-7lj4bfli	142	30	,	,	,
cord-265900-7lj4bfli	142	31	and	and	CC
cord-265900-7lj4bfli	142	32	protein	protein	NN
cord-265900-7lj4bfli	142	33	kinase	kinase	NN
cord-265900-7lj4bfli	142	34	R	r	NN
cord-265900-7lj4bfli	142	35	[	[	-LRB-
cord-265900-7lj4bfli	142	36	93	93	CD
cord-265900-7lj4bfli	142	37	]	]	-RRB-
cord-265900-7lj4bfli	142	38	,	,	,
cord-265900-7lj4bfli	142	39	have	have	VBP
cord-265900-7lj4bfli	142	40	been	be	VBN
cord-265900-7lj4bfli	142	41	shown	show	VBN
cord-265900-7lj4bfli	142	42	to	to	TO
cord-265900-7lj4bfli	142	43	undergo	undergo	VB
cord-265900-7lj4bfli	142	44	ISGylation	ISGylation	NNP
cord-265900-7lj4bfli	142	45	,	,	,
cord-265900-7lj4bfli	142	46	resulting	result	VBG
cord-265900-7lj4bfli	142	47	in	in	IN
cord-265900-7lj4bfli	142	48	a	a	DT
cord-265900-7lj4bfli	142	49	gain	gain	NN
cord-265900-7lj4bfli	142	50	-	-	HYPH
cord-265900-7lj4bfli	142	51	of	of	IN
cord-265900-7lj4bfli	142	52	-	-	HYPH
cord-265900-7lj4bfli	142	53	function	function	NN
cord-265900-7lj4bfli	142	54	of	of	IN
cord-265900-7lj4bfli	142	55	these	these	DT
cord-265900-7lj4bfli	142	56	proteins	protein	NNS
cord-265900-7lj4bfli	142	57	and	and	CC
cord-265900-7lj4bfli	142	58	consequent	consequent	JJ
cord-265900-7lj4bfli	142	59	anti	anti	JJ
cord-265900-7lj4bfli	142	60	-	-	JJ
cord-265900-7lj4bfli	142	61	viral	viral	JJ
cord-265900-7lj4bfli	142	62	immune	immune	JJ
cord-265900-7lj4bfli	142	63	response	response	NN
cord-265900-7lj4bfli	142	64	.	.	.
cord-265900-7lj4bfli	143	1	To	to	TO
cord-265900-7lj4bfli	143	2	overcome	overcome	VB
cord-265900-7lj4bfli	143	3	host	host	NN
cord-265900-7lj4bfli	143	4	innate	innate	JJ
cord-265900-7lj4bfli	143	5	defense	defense	NN
cord-265900-7lj4bfli	143	6	,	,	,
cord-265900-7lj4bfli	143	7	viruses	virus	NNS
cord-265900-7lj4bfli	143	8	have	have	VBP
cord-265900-7lj4bfli	143	9	evolved	evolve	VBN
cord-265900-7lj4bfli	143	10	to	to	TO
cord-265900-7lj4bfli	143	11	interfere	interfere	VB
cord-265900-7lj4bfli	143	12	with	with	IN
cord-265900-7lj4bfli	143	13	the	the	DT
cord-265900-7lj4bfli	143	14	ISG15	ISG15	NNP
cord-265900-7lj4bfli	143	15	conjugation	conjugation	NN
cord-265900-7lj4bfli	143	16	system	system	NN
cord-265900-7lj4bfli	143	17	to	to	TO
cord-265900-7lj4bfli	143	18	antagonize	antagonize	VB
cord-265900-7lj4bfli	143	19	its	-PRON-	PRP$
cord-265900-7lj4bfli	143	20	anti	anti	JJ
cord-265900-7lj4bfli	143	21	-	-	JJ
cord-265900-7lj4bfli	143	22	viral	viral	JJ
cord-265900-7lj4bfli	143	23	activity	activity	NN
cord-265900-7lj4bfli	143	24	.	.	.
cord-265900-7lj4bfli	144	1	For	for	IN
cord-265900-7lj4bfli	144	2	instance	instance	NN
cord-265900-7lj4bfli	144	3	,	,	,
cord-265900-7lj4bfli	144	4	it	-PRON-	PRP
cord-265900-7lj4bfli	144	5	was	be	VBD
cord-265900-7lj4bfli	144	6	reported	report	VBN
cord-265900-7lj4bfli	144	7	that	that	IN
cord-265900-7lj4bfli	144	8	the	the	DT
cord-265900-7lj4bfli	144	9	influenza	influenza	NN
cord-265900-7lj4bfli	144	10	B	b	NN
cord-265900-7lj4bfli	144	11	virus	virus	NN
cord-265900-7lj4bfli	144	12	NS1	ns1	CD
cord-265900-7lj4bfli	144	13	[	[	-LRB-
cord-265900-7lj4bfli	144	14	94	94	CD
cord-265900-7lj4bfli	144	15	]	]	-RRB-
cord-265900-7lj4bfli	144	16	and	and	CC
cord-265900-7lj4bfli	144	17	vaccinia	vaccinia	NN
cord-265900-7lj4bfli	144	18	E3	e3	NN
cord-265900-7lj4bfli	144	19	protein	protein	NN
cord-265900-7lj4bfli	144	20	[	[	-LRB-
cord-265900-7lj4bfli	144	21	95	95	CD
cord-265900-7lj4bfli	144	22	]	]	-RRB-
cord-265900-7lj4bfli	144	23	interact	interact	VBP
cord-265900-7lj4bfli	144	24	with	with	IN
cord-265900-7lj4bfli	144	25	ISG15	ISG15	NNP
cord-265900-7lj4bfli	144	26	to	to	TO
cord-265900-7lj4bfli	144	27	prevent	prevent	VB
cord-265900-7lj4bfli	144	28	it	-PRON-	PRP
cord-265900-7lj4bfli	144	29	from	from	IN
cord-265900-7lj4bfli	144	30	binding	bind	VBG
cord-265900-7lj4bfli	144	31	to	to	IN
cord-265900-7lj4bfli	144	32	UBE1L	ube1l	NN
cord-265900-7lj4bfli	144	33	,	,	,
cord-265900-7lj4bfli	144	34	thus	thus	RB
cord-265900-7lj4bfli	144	35	inhibiting	inhibit	VBG
cord-265900-7lj4bfli	144	36	the	the	DT
cord-265900-7lj4bfli	144	37	formation	formation	NN
cord-265900-7lj4bfli	144	38	of	of	IN
cord-265900-7lj4bfli	144	39	ISG15	isg15	NN
cord-265900-7lj4bfli	144	40	conjugates	conjugate	NNS
cord-265900-7lj4bfli	144	41	.	.	.
cord-265900-7lj4bfli	145	1	Furthermore	furthermore	RB
cord-265900-7lj4bfli	145	2	,	,	,
cord-265900-7lj4bfli	145	3	some	some	DT
cord-265900-7lj4bfli	145	4	viruses	virus	NNS
cord-265900-7lj4bfli	145	5	can	can	MD
cord-265900-7lj4bfli	145	6	encode	encode	VB
cord-265900-7lj4bfli	145	7	their	-PRON-	PRP$
cord-265900-7lj4bfli	145	8	own	own	JJ
cord-265900-7lj4bfli	145	9	deISGylating	deisgylate	VBG
cord-265900-7lj4bfli	145	10	enzyme	enzyme	NN
cord-265900-7lj4bfli	145	11	to	to	TO
cord-265900-7lj4bfli	145	12	disrupt	disrupt	VB
cord-265900-7lj4bfli	145	13	ISG15	isg15	NN
cord-265900-7lj4bfli	145	14	conjugation	conjugation	NN
cord-265900-7lj4bfli	145	15	.	.	.
cord-265900-7lj4bfli	146	1	For	for	IN
cord-265900-7lj4bfli	146	2	example	example	NN
cord-265900-7lj4bfli	146	3	,	,	,
cord-265900-7lj4bfli	146	4	the	the	DT
cord-265900-7lj4bfli	146	5	papain	papain	NN
cord-265900-7lj4bfli	146	6	-	-	HYPH
cord-265900-7lj4bfli	146	7	like	like	JJ
cord-265900-7lj4bfli	146	8	protease	protease	NN
cord-265900-7lj4bfli	146	9	of	of	IN
cord-265900-7lj4bfli	146	10	SARS	SARS	NNP
cord-265900-7lj4bfli	146	11	-	-	HYPH
cord-265900-7lj4bfli	146	12	CoV	CoV	NNP
cord-265900-7lj4bfli	146	13	[	[	-LRB-
cord-265900-7lj4bfli	146	14	96	96	CD
cord-265900-7lj4bfli	146	15	]	]	-RRB-
cord-265900-7lj4bfli	146	16	and	and	CC
cord-265900-7lj4bfli	146	17	the	the	DT
cord-265900-7lj4bfli	146	18	ovarian	ovarian	JJ
cord-265900-7lj4bfli	146	19	tumor	tumor	NN
cord-265900-7lj4bfli	146	20	domain	domain	NN
cord-265900-7lj4bfli	146	21	-	-	HYPH
cord-265900-7lj4bfli	146	22	containing	contain	VBG
cord-265900-7lj4bfli	146	23	protease	protease	NN
cord-265900-7lj4bfli	146	24	of	of	IN
cord-265900-7lj4bfli	146	25	nairoviruses	nairoviruse	NNS
cord-265900-7lj4bfli	146	26	and	and	CC
cord-265900-7lj4bfli	146	27	arteriviruses	arteriviruse	NNS
cord-265900-7lj4bfli	146	28	[	[	-LRB-
cord-265900-7lj4bfli	146	29	97	97	CD
cord-265900-7lj4bfli	146	30	,	,	,
cord-265900-7lj4bfli	146	31	98	98	CD
cord-265900-7lj4bfli	146	32	]	]	-RRB-
cord-265900-7lj4bfli	146	33	possess	possess	VBP
cord-265900-7lj4bfli	146	34	both	both	DT
cord-265900-7lj4bfli	146	35	deISGylating	deisgylate	VBG
cord-265900-7lj4bfli	146	36	and	and	CC
cord-265900-7lj4bfli	146	37	deubiquitinating	deubiquitinating	NN
cord-265900-7lj4bfli	146	38	activity	activity	NN
cord-265900-7lj4bfli	146	39	that	that	WDT
cord-265900-7lj4bfli	146	40	counteracts	counteract	VBZ
cord-265900-7lj4bfli	146	41	the	the	DT
cord-265900-7lj4bfli	146	42	post	post	JJ
cord-265900-7lj4bfli	146	43	-	-	JJ
cord-265900-7lj4bfli	146	44	translational	translational	JJ
cord-265900-7lj4bfli	146	45	modification	modification	NN
cord-265900-7lj4bfli	146	46	of	of	IN
cord-265900-7lj4bfli	146	47	signaling	signal	VBG
cord-265900-7lj4bfli	146	48	molecules	molecule	NNS
cord-265900-7lj4bfli	146	49	involved	involve	VBN
cord-265900-7lj4bfli	146	50	in	in	IN
cord-265900-7lj4bfli	146	51	the	the	DT
cord-265900-7lj4bfli	146	52	innate	innate	JJ
cord-265900-7lj4bfli	146	53	immune	immune	JJ
cord-265900-7lj4bfli	146	54	response	response	NN
cord-265900-7lj4bfli	146	55	.	.	.
cord-265900-7lj4bfli	147	1	Growing	grow	VBG
cord-265900-7lj4bfli	147	2	evidence	evidence	NN
cord-265900-7lj4bfli	147	3	has	have	VBZ
cord-265900-7lj4bfli	147	4	indicated	indicate	VBN
cord-265900-7lj4bfli	147	5	a	a	DT
cord-265900-7lj4bfli	147	6	dual	dual	JJ
cord-265900-7lj4bfli	147	7	role	role	NN
cord-265900-7lj4bfli	147	8	for	for	IN
cord-265900-7lj4bfli	147	9	the	the	DT
cord-265900-7lj4bfli	147	10	UPS	up	NNS
cord-265900-7lj4bfli	147	11	in	in	IN
cord-265900-7lj4bfli	147	12	viral	viral	JJ
cord-265900-7lj4bfli	147	13	pathogenesis	pathogenesis	NN
cord-265900-7lj4bfli	147	14	(	(	-LRB-
cord-265900-7lj4bfli	147	15	summarized	summarize	VBN
cord-265900-7lj4bfli	147	16	in	in	IN
cord-265900-7lj4bfli	147	17	Figure	Figure	NNP
cord-265900-7lj4bfli	147	18	1	1	CD
cord-265900-7lj4bfli	147	19	and	and	CC
cord-265900-7lj4bfli	147	20	Table	Table	NNP
cord-265900-7lj4bfli	147	21	1	1	CD
cord-265900-7lj4bfli	147	22	)	)	-RRB-
cord-265900-7lj4bfli	147	23	.	.	.
cord-265900-7lj4bfli	148	1	The	the	DT
cord-265900-7lj4bfli	148	2	UPS	UPS	NNP
cord-265900-7lj4bfli	148	3	may	may	MD
cord-265900-7lj4bfli	148	4	represent	represent	VB
cord-265900-7lj4bfli	148	5	a	a	DT
cord-265900-7lj4bfli	148	6	host	host	NN
cord-265900-7lj4bfli	148	7	defense	defense	NN
cord-265900-7lj4bfli	148	8	mechanism	mechanism	NN
cord-265900-7lj4bfli	148	9	against	against	IN
cord-265900-7lj4bfli	148	10	viral	viral	JJ
cord-265900-7lj4bfli	148	11	infection	infection	NN
cord-265900-7lj4bfli	148	12	,	,	,
cord-265900-7lj4bfli	148	13	or	or	CC
cord-265900-7lj4bfli	148	14	they	-PRON-	PRP
cord-265900-7lj4bfli	148	15	may	may	MD
cord-265900-7lj4bfli	148	16	be	be	VB
cord-265900-7lj4bfli	148	17	hijacked	hijack	VBN
cord-265900-7lj4bfli	148	18	by	by	IN
cord-265900-7lj4bfli	148	19	the	the	DT
cord-265900-7lj4bfli	148	20	virus	virus	NN
cord-265900-7lj4bfli	148	21	to	to	TO
cord-265900-7lj4bfli	148	22	enhance	enhance	VB
cord-265900-7lj4bfli	148	23	its	-PRON-	PRP$
cord-265900-7lj4bfli	148	24	infectivity	infectivity	NN
cord-265900-7lj4bfli	148	25	.	.	.
cord-265900-7lj4bfli	149	1	Viral	viral	JJ
cord-265900-7lj4bfli	149	2	manipulation	manipulation	NN
cord-265900-7lj4bfli	149	3	of	of	IN
cord-265900-7lj4bfli	149	4	the	the	DT
cord-265900-7lj4bfli	149	5	UPS	UPS	NNP
cord-265900-7lj4bfli	149	6	has	have	VBZ
cord-265900-7lj4bfli	149	7	emerged	emerge	VBN
cord-265900-7lj4bfli	149	8	as	as	IN
cord-265900-7lj4bfli	149	9	a	a	DT
cord-265900-7lj4bfli	149	10	central	central	JJ
cord-265900-7lj4bfli	149	11	immune	immune	JJ
cord-265900-7lj4bfli	149	12	evasion	evasion	NN
cord-265900-7lj4bfli	149	13	mechanism	mechanism	NN
cord-265900-7lj4bfli	149	14	.	.	.
cord-265900-7lj4bfli	150	1	Viruses	virus	NNS
cord-265900-7lj4bfli	150	2	evolve	evolve	VBP
cord-265900-7lj4bfli	150	3	to	to	TO
cord-265900-7lj4bfli	150	4	inhibit	inhibit	VB
cord-265900-7lj4bfli	150	5	many	many	JJ
cord-265900-7lj4bfli	150	6	facets	facet	NNS
cord-265900-7lj4bfli	150	7	of	of	IN
cord-265900-7lj4bfli	150	8	the	the	DT
cord-265900-7lj4bfli	150	9	host	host	NN
cord-265900-7lj4bfli	150	10	anti	anti	JJ
cord-265900-7lj4bfli	150	11	-	-	JJ
cord-265900-7lj4bfli	150	12	viral	viral	JJ
cord-265900-7lj4bfli	150	13	immune	immune	JJ
cord-265900-7lj4bfli	150	14	response	response	NN
cord-265900-7lj4bfli	150	15	.	.	.
cord-265900-7lj4bfli	151	1	In	in	IN
cord-265900-7lj4bfli	151	2	some	some	DT
cord-265900-7lj4bfli	151	3	cases	case	NNS
cord-265900-7lj4bfli	151	4	,	,	,
cord-265900-7lj4bfli	151	5	viruses	virus	NNS
cord-265900-7lj4bfli	151	6	produce	produce	VBP
cord-265900-7lj4bfli	151	7	proteins	protein	NNS
cord-265900-7lj4bfli	151	8	to	to	TO
cord-265900-7lj4bfli	151	9	mimic	mimic	VB
cord-265900-7lj4bfli	151	10	the	the	DT
cord-265900-7lj4bfli	151	11	function	function	NN
cord-265900-7lj4bfli	151	12	of	of	IN
cord-265900-7lj4bfli	151	13	the	the	DT
cord-265900-7lj4bfli	151	14	UPS	up	NNS
cord-265900-7lj4bfli	151	15	or	or	CC
cord-265900-7lj4bfli	151	16	to	to	TO
cord-265900-7lj4bfli	151	17	redirect	redirect	VB
cord-265900-7lj4bfli	151	18	the	the	DT
cord-265900-7lj4bfli	151	19	cellular	cellular	JJ
cord-265900-7lj4bfli	151	20	E3	e3	NN
cord-265900-7lj4bfli	151	21	to	to	TO
cord-265900-7lj4bfli	151	22	allow	allow	VB
cord-265900-7lj4bfli	151	23	for	for	IN
cord-265900-7lj4bfli	151	24	targeted	target	VBN
cord-265900-7lj4bfli	151	25	degradation	degradation	NN
cord-265900-7lj4bfli	151	26	of	of	IN
cord-265900-7lj4bfli	151	27	cellular	cellular	JJ
cord-265900-7lj4bfli	151	28	factors	factor	NNS
cord-265900-7lj4bfli	151	29	or	or	CC
cord-265900-7lj4bfli	151	30	viral	viral	JJ
cord-265900-7lj4bfli	151	31	proteins	protein	NNS
cord-265900-7lj4bfli	151	32	that	that	WDT
cord-265900-7lj4bfli	151	33	might	may	MD
cord-265900-7lj4bfli	151	34	hinder	hinder	VB
cord-265900-7lj4bfli	151	35	viral	viral	JJ
cord-265900-7lj4bfli	151	36	replication	replication	NN
cord-265900-7lj4bfli	151	37	.	.	.
cord-265900-7lj4bfli	152	1	In	in	IN
cord-265900-7lj4bfli	152	2	others	other	NNS
cord-265900-7lj4bfli	152	3	cases	case	NNS
cord-265900-7lj4bfli	152	4	,	,	,
cord-265900-7lj4bfli	152	5	they	-PRON-	PRP
cord-265900-7lj4bfli	152	6	encode	encode	VBP
cord-265900-7lj4bfli	152	7	proteins	protein	NNS
cord-265900-7lj4bfli	152	8	to	to	TO
cord-265900-7lj4bfli	152	9	interfere	interfere	VB
cord-265900-7lj4bfli	152	10	with	with	IN
cord-265900-7lj4bfli	152	11	the	the	DT
cord-265900-7lj4bfli	152	12	host	host	NN
cord-265900-7lj4bfli	152	13	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	152	14	or	or	CC
cord-265900-7lj4bfli	152	15	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	152	16	-	-	HYPH
cord-265900-7lj4bfli	152	17	like	like	JJ
cord-265900-7lj4bfli	152	18	(	(	-LRB-
cord-265900-7lj4bfli	152	19	e.g.	e.g.	JJ
cord-265900-7lj4bfli	152	20	SUMO	SUMO	NNP
cord-265900-7lj4bfli	152	21	and	and	CC
cord-265900-7lj4bfli	152	22	ISG15	isg15	NN
cord-265900-7lj4bfli	152	23	)	)	-RRB-
cord-265900-7lj4bfli	152	24	conjugation	conjugation	NN
cord-265900-7lj4bfli	152	25	system	system	NN
cord-265900-7lj4bfli	152	26	to	to	TO
cord-265900-7lj4bfli	152	27	inactivate	inactivate	VB
cord-265900-7lj4bfli	152	28	the	the	DT
cord-265900-7lj4bfli	152	29	host	host	NN
cord-265900-7lj4bfli	152	30	anti	anti	JJ
cord-265900-7lj4bfli	152	31	-	-	JJ
cord-265900-7lj4bfli	152	32	viral	viral	JJ
cord-265900-7lj4bfli	152	33	signaling	signal	VBG
cord-265900-7lj4bfli	152	34	pathways	pathway	NNS
cord-265900-7lj4bfli	152	35	.	.	.
cord-265900-7lj4bfli	153	1	In	in	IN
cord-265900-7lj4bfli	153	2	many	many	JJ
cord-265900-7lj4bfli	153	3	cases	case	NNS
cord-265900-7lj4bfli	153	4	,	,	,
cord-265900-7lj4bfli	153	5	these	these	DT
cord-265900-7lj4bfli	153	6	mechanisms	mechanism	NNS
cord-265900-7lj4bfli	153	7	work	work	VBP
cord-265900-7lj4bfli	153	8	together	together	RB
cord-265900-7lj4bfli	153	9	to	to	TO
cord-265900-7lj4bfli	153	10	dynamically	dynamically	RB
cord-265900-7lj4bfli	153	11	modulate	modulate	VB
cord-265900-7lj4bfli	153	12	the	the	DT
cord-265900-7lj4bfli	153	13	function	function	NN
cord-265900-7lj4bfli	153	14	of	of	IN
cord-265900-7lj4bfli	153	15	the	the	DT
cord-265900-7lj4bfli	153	16	UPS	UPS	NNP
cord-265900-7lj4bfli	153	17	to	to	TO
cord-265900-7lj4bfli	153	18	gain	gain	VB
cord-265900-7lj4bfli	153	19	maximal	maximal	JJ
cord-265900-7lj4bfli	153	20	viral	viral	JJ
cord-265900-7lj4bfli	153	21	infection	infection	NN
cord-265900-7lj4bfli	153	22	.	.	.
cord-265900-7lj4bfli	154	1	A	a	DT
cord-265900-7lj4bfli	154	2	better	well	JJR
cord-265900-7lj4bfli	154	3	understanding	understanding	NN
cord-265900-7lj4bfli	154	4	of	of	IN
cord-265900-7lj4bfli	154	5	the	the	DT
cord-265900-7lj4bfli	154	6	complicated	complicated	JJ
cord-265900-7lj4bfli	154	7	interaction	interaction	NN
cord-265900-7lj4bfli	154	8	between	between	IN
cord-265900-7lj4bfli	154	9	the	the	DT
cord-265900-7lj4bfli	154	10	virus	virus	NN
cord-265900-7lj4bfli	154	11	and	and	CC
cord-265900-7lj4bfli	154	12	the	the	DT
cord-265900-7lj4bfli	154	13	host	host	NN
cord-265900-7lj4bfli	154	14	UPS	up	NNS
cord-265900-7lj4bfli	154	15	with	with	IN
cord-265900-7lj4bfli	154	16	further	further	JJ
cord-265900-7lj4bfli	154	17	identification	identification	NN
cord-265900-7lj4bfli	154	18	of	of	IN
cord-265900-7lj4bfli	154	19	the	the	DT
cord-265900-7lj4bfli	154	20	new	new	JJ
cord-265900-7lj4bfli	154	21	targets	target	NNS
cord-265900-7lj4bfli	154	22	for	for	IN
cord-265900-7lj4bfli	154	23	viral	viral	JJ
cord-265900-7lj4bfli	154	24	E3s	e3s	NN
cord-265900-7lj4bfli	154	25	or	or	CC
cord-265900-7lj4bfli	154	26	DUBs	dub	NNS
cord-265900-7lj4bfli	154	27	and	and	CC
cord-265900-7lj4bfli	154	28	careful	careful	JJ
cord-265900-7lj4bfli	154	29	characterization	characterization	NN
cord-265900-7lj4bfli	154	30	of	of	IN
cord-265900-7lj4bfli	154	31	the	the	DT
cord-265900-7lj4bfli	154	32	functional	functional	JJ
cord-265900-7lj4bfli	154	33	consequence	consequence	NN
cord-265900-7lj4bfli	154	34	of	of	IN
cord-265900-7lj4bfli	154	35	the	the	DT
cord-265900-7lj4bfli	154	36	ubiquitin	ubiquitin	JJ
cord-265900-7lj4bfli	154	37	modification	modification	NN
cord-265900-7lj4bfli	154	38	or	or	CC
cord-265900-7lj4bfli	154	39	degradation	degradation	NN
cord-265900-7lj4bfli	154	40	events	event	NNS
cord-265900-7lj4bfli	154	41	will	will	MD
cord-265900-7lj4bfli	154	42	provide	provide	VB
cord-265900-7lj4bfli	154	43	novel	novel	JJ
cord-265900-7lj4bfli	154	44	insights	insight	NNS
cord-265900-7lj4bfli	154	45	into	into	IN
cord-265900-7lj4bfli	154	46	the	the	DT
cord-265900-7lj4bfli	154	47	mechanism	mechanism	NN
cord-265900-7lj4bfli	154	48	of	of	IN
cord-265900-7lj4bfli	154	49	viral	viral	JJ
cord-265900-7lj4bfli	154	50	pathogenesis	pathogenesis	NN
cord-265900-7lj4bfli	154	51	,	,	,
cord-265900-7lj4bfli	154	52	facilitate	facilitate	VB
cord-265900-7lj4bfli	154	53	the	the	DT
cord-265900-7lj4bfli	154	54	discovery	discovery	NN
cord-265900-7lj4bfli	154	55	of	of	IN
cord-265900-7lj4bfli	154	56	new	new	JJ
cord-265900-7lj4bfli	154	57	immune	immune	JJ
cord-265900-7lj4bfli	154	58	modulators	modulator	NNS
cord-265900-7lj4bfli	154	59	,	,	,
cord-265900-7lj4bfli	154	60	and	and	CC
cord-265900-7lj4bfli	154	61	promote	promote	VB
cord-265900-7lj4bfli	154	62	the	the	DT
cord-265900-7lj4bfli	154	63	development	development	NN
cord-265900-7lj4bfli	154	64	of	of	IN
cord-265900-7lj4bfli	154	65	efficient	efficient	JJ
cord-265900-7lj4bfli	154	66	antiviral	antiviral	JJ
cord-265900-7lj4bfli	154	67	interventions	intervention	NNS
cord-265900-7lj4bfli	154	68	.	.	.
cord-265900-7lj4bfli	155	1	Nothing	nothing	NN
cord-265900-7lj4bfli	155	2	declared	declare	VBD
cord-265900-7lj4bfli	155	3	.	.	.
cord-265900-7lj4bfli	155	4	 	 	_SP
cord-265900-7lj4bfli	156	1	Themes	theme	NNS
cord-265900-7lj4bfli	156	2	and	and	CC
cord-265900-7lj4bfli	156	3	variations	variation	NNS
cord-265900-7lj4bfli	156	4	on	on	IN
cord-265900-7lj4bfli	156	5	ubiquitylation	ubiquitylation	NN
cord-265900-7lj4bfli	156	6	Ubiquitin	Ubiquitin	NNP
cord-265900-7lj4bfli	156	7	branches	branch	NNS
cord-265900-7lj4bfli	156	8	out	out	RP
cord-265900-7lj4bfli	156	9	Sumoylation	Sumoylation	NNP
cord-265900-7lj4bfli	156	10	:	:	:
cord-265900-7lj4bfli	156	11	a	a	DT
cord-265900-7lj4bfli	156	12	regulatory	regulatory	JJ
cord-265900-7lj4bfli	156	13	protein	protein	NN
cord-265900-7lj4bfli	156	14	modification	modification	NN
cord-265900-7lj4bfli	156	15	in	in	IN
cord-265900-7lj4bfli	156	16	health	health	NN
cord-265900-7lj4bfli	156	17	and	and	CC
cord-265900-7lj4bfli	156	18	disease	disease	NN
cord-265900-7lj4bfli	156	19	Concepts	concept	NNS
cord-265900-7lj4bfli	156	20	in	in	IN
cord-265900-7lj4bfli	156	21	sumoylation	sumoylation	NN
cord-265900-7lj4bfli	156	22	:	:	:
cord-265900-7lj4bfli	156	23	a	a	DT
cord-265900-7lj4bfli	156	24	decade	decade	NN
cord-265900-7lj4bfli	156	25	on	on	IN
cord-265900-7lj4bfli	156	26	Emerging	emerge	VBG
cord-265900-7lj4bfli	156	27	role	role	NN
cord-265900-7lj4bfli	156	28	of	of	IN
cord-265900-7lj4bfli	156	29	ISG15	isg15	NN
cord-265900-7lj4bfli	156	30	in	in	IN
cord-265900-7lj4bfli	156	31	antiviral	antiviral	JJ
cord-265900-7lj4bfli	156	32	immunity	immunity	NN
cord-265900-7lj4bfli	156	33	Interferon	Interferon	NNP
cord-265900-7lj4bfli	156	34	-	-	HYPH
cord-265900-7lj4bfli	156	35	stimulated	stimulate	VBN
cord-265900-7lj4bfli	156	36	gene	gene	NN
cord-265900-7lj4bfli	156	37	15	15	CD
cord-265900-7lj4bfli	156	38	and	and	CC
cord-265900-7lj4bfli	156	39	the	the	DT
cord-265900-7lj4bfli	156	40	protein	protein	NN
cord-265900-7lj4bfli	156	41	ISGylation	isgylation	NN
cord-265900-7lj4bfli	156	42	system	system	NN
cord-265900-7lj4bfli	156	43	Ubiquitin	Ubiquitin	NNP
cord-265900-7lj4bfli	156	44	and	and	CC
cord-265900-7lj4bfli	156	45	plant	plant	NN
cord-265900-7lj4bfli	156	46	viruses	virus	NNS
cord-265900-7lj4bfli	156	47	,	,	,
cord-265900-7lj4bfli	156	48	let	let	VB
cord-265900-7lj4bfli	156	49	's	-PRON-	PRP
cord-265900-7lj4bfli	156	50	play	play	VB
cord-265900-7lj4bfli	156	51	together	together	RB
cord-265900-7lj4bfli	156	52	The	the	DT
cord-265900-7lj4bfli	156	53	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	156	54	-	-	HYPH
cord-265900-7lj4bfli	156	55	proteasome	proteasome	VBN
cord-265900-7lj4bfli	156	56	pathway	pathway	NN
cord-265900-7lj4bfli	156	57	in	in	IN
cord-265900-7lj4bfli	156	58	viral	viral	JJ
cord-265900-7lj4bfli	156	59	infections	infection	NNS
cord-265900-7lj4bfli	156	60	Ubiquitination	Ubiquitination	NNP
cord-265900-7lj4bfli	156	61	,	,	,
cord-265900-7lj4bfli	156	62	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	156	63	-	-	HYPH
cord-265900-7lj4bfli	156	64	like	like	JJ
cord-265900-7lj4bfli	156	65	modifiers	modifier	NNS
cord-265900-7lj4bfli	156	66	,	,	,
cord-265900-7lj4bfli	156	67	and	and	CC
cord-265900-7lj4bfli	156	68	deubiquitination	deubiquitination	NN
cord-265900-7lj4bfli	156	69	in	in	IN
cord-265900-7lj4bfli	156	70	viral	viral	JJ
cord-265900-7lj4bfli	156	71	infection	infection	NN
cord-265900-7lj4bfli	157	1	The	the	DT
cord-265900-7lj4bfli	157	2	tumor	tumor	NN
cord-265900-7lj4bfli	157	3	suppressor	suppressor	NN
cord-265900-7lj4bfli	157	4	protein	protein	NN
cord-265900-7lj4bfli	157	5	p53	p53	NN
cord-265900-7lj4bfli	157	6	strongly	strongly	RB
cord-265900-7lj4bfli	157	7	alters	alter	VBZ
cord-265900-7lj4bfli	157	8	human	human	JJ
cord-265900-7lj4bfli	157	9	immunodeficiency	immunodeficiency	NN
cord-265900-7lj4bfli	157	10	virus	virus	NN
cord-265900-7lj4bfli	157	11	type	type	NN
cord-265900-7lj4bfli	157	12	1	1	CD
cord-265900-7lj4bfli	157	13	replication	replication	NN
cord-265900-7lj4bfli	157	14	Downregulation	Downregulation	NNP
cord-265900-7lj4bfli	157	15	of	of	IN
cord-265900-7lj4bfli	157	16	p53	p53	NN
cord-265900-7lj4bfli	157	17	by	by	IN
cord-265900-7lj4bfli	157	18	double	double	RB
cord-265900-7lj4bfli	157	19	-	-	HYPH
cord-265900-7lj4bfli	157	20	stranded	strand	VBN
cord-265900-7lj4bfli	157	21	RNA	RNA	NNP
cord-265900-7lj4bfli	157	22	modulates	modulate	VBZ
cord-265900-7lj4bfli	157	23	the	the	DT
cord-265900-7lj4bfli	157	24	antiviral	antiviral	JJ
cord-265900-7lj4bfli	157	25	response	response	NN
cord-265900-7lj4bfli	157	26	The	the	DT
cord-265900-7lj4bfli	157	27	HPV-16	HPV-16	NNP
cord-265900-7lj4bfli	157	28	E6	E6	NNP
cord-265900-7lj4bfli	157	29	and	and	CC
cord-265900-7lj4bfli	157	30	E6-AP	e6-ap	JJ
cord-265900-7lj4bfli	157	31	complex	complex	JJ
cord-265900-7lj4bfli	157	32	functions	function	NNS
cord-265900-7lj4bfli	157	33	as	as	IN
cord-265900-7lj4bfli	157	34	a	a	DT
cord-265900-7lj4bfli	157	35	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	157	36	-	-	HYPH
cord-265900-7lj4bfli	157	37	protein	protein	NN
cord-265900-7lj4bfli	157	38	ligase	ligase	NN
cord-265900-7lj4bfli	157	39	in	in	IN
cord-265900-7lj4bfli	157	40	the	the	DT
cord-265900-7lj4bfli	157	41	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	157	42	of	of	IN
cord-265900-7lj4bfli	157	43	p53	p53	NN
cord-265900-7lj4bfli	158	1	The	the	DT
cord-265900-7lj4bfli	158	2	E6	E6	NNP
cord-265900-7lj4bfli	158	3	oncoprotein	oncoprotein	NN
cord-265900-7lj4bfli	158	4	encoded	encode	VBN
cord-265900-7lj4bfli	158	5	by	by	IN
cord-265900-7lj4bfli	158	6	human	human	JJ
cord-265900-7lj4bfli	158	7	papillomavirus	papillomavirus	NN
cord-265900-7lj4bfli	158	8	types	type	NNS
cord-265900-7lj4bfli	158	9	16	16	CD
cord-265900-7lj4bfli	158	10	and	and	CC
cord-265900-7lj4bfli	158	11	18	18	CD
cord-265900-7lj4bfli	158	12	promotes	promote	VBZ
cord-265900-7lj4bfli	158	13	the	the	DT
cord-265900-7lj4bfli	158	14	degradation	degradation	NN
cord-265900-7lj4bfli	158	15	of	of	IN
cord-265900-7lj4bfli	158	16	p53	p53	NN
cord-265900-7lj4bfli	158	17	Degradation	degradation	NN
cord-265900-7lj4bfli	158	18	of	of	IN
cord-265900-7lj4bfli	158	19	p53	p53	NN
cord-265900-7lj4bfli	158	20	by	by	IN
cord-265900-7lj4bfli	159	1	adenovirus	adenovirus	NN
cord-265900-7lj4bfli	159	2	E4orf6	E4orf6	NNP
cord-265900-7lj4bfli	159	3	and	and	CC
cord-265900-7lj4bfli	159	4	E1B55	E1B55	NNP
cord-265900-7lj4bfli	159	5	K	k	NN
cord-265900-7lj4bfli	159	6	proteins	protein	NNS
cord-265900-7lj4bfli	159	7	occurs	occur	VBZ
cord-265900-7lj4bfli	159	8	via	via	IN
cord-265900-7lj4bfli	159	9	a	a	DT
cord-265900-7lj4bfli	159	10	novel	novel	JJ
cord-265900-7lj4bfli	159	11	mechanism	mechanism	NN
cord-265900-7lj4bfli	159	12	involving	involve	VBG
cord-265900-7lj4bfli	159	13	a	a	DT
cord-265900-7lj4bfli	159	14	Cullin	Cullin	NNP
cord-265900-7lj4bfli	159	15	-	-	HYPH
cord-265900-7lj4bfli	159	16	containing	contain	VBG
cord-265900-7lj4bfli	159	17	complex	complex	JJ
cord-265900-7lj4bfli	159	18	Transgenic	transgenic	JJ
cord-265900-7lj4bfli	159	19	expression	expression	NN
cord-265900-7lj4bfli	159	20	of	of	IN
cord-265900-7lj4bfli	159	21	the	the	DT
cord-265900-7lj4bfli	159	22	3D	3d	JJ
cord-265900-7lj4bfli	159	23	polymerase	polymerase	NN
cord-265900-7lj4bfli	159	24	inhibits	inhibit	VBZ
cord-265900-7lj4bfli	159	25	Theiler	Theiler	NNP
cord-265900-7lj4bfli	159	26	's	's	POS
cord-265900-7lj4bfli	159	27	virus	virus	NN
cord-265900-7lj4bfli	159	28	infection	infection	NN
cord-265900-7lj4bfli	159	29	and	and	CC
cord-265900-7lj4bfli	159	30	demyelination	demyelination	NN
cord-265900-7lj4bfli	160	1	The	the	DT
cord-265900-7lj4bfli	160	2	ubiquitinproteasome	ubiquitinproteasome	NN
cord-265900-7lj4bfli	160	3	system	system	NN
cord-265900-7lj4bfli	160	4	regulates	regulate	VBZ
cord-265900-7lj4bfli	160	5	the	the	DT
cord-265900-7lj4bfli	160	6	accumulation	accumulation	NN
cord-265900-7lj4bfli	160	7	of	of	IN
cord-265900-7lj4bfli	160	8	Turnip	Turnip	NNP
cord-265900-7lj4bfli	160	9	yellow	yellow	JJ
cord-265900-7lj4bfli	160	10	mosaic	mosaic	JJ
cord-265900-7lj4bfli	160	11	virus	virus	NN
cord-265900-7lj4bfli	160	12	RNA	rna	NN
cord-265900-7lj4bfli	160	13	-	-	HYPH
cord-265900-7lj4bfli	160	14	dependent	dependent	JJ
cord-265900-7lj4bfli	160	15	RNA	RNA	NNP
cord-265900-7lj4bfli	160	16	polymerase	polymerase	NN
cord-265900-7lj4bfli	160	17	during	during	IN
cord-265900-7lj4bfli	160	18	viral	viral	JJ
cord-265900-7lj4bfli	160	19	infection	infection	NN
cord-265900-7lj4bfli	160	20	Sindbis	Sindbis	NNP
cord-265900-7lj4bfli	160	21	virus	virus	NN
cord-265900-7lj4bfli	160	22	RNA	rna	NN
cord-265900-7lj4bfli	160	23	polymerase	polymerase	NN
cord-265900-7lj4bfli	160	24	is	be	VBZ
cord-265900-7lj4bfli	160	25	degraded	degrade	VBN
cord-265900-7lj4bfli	160	26	by	by	IN
cord-265900-7lj4bfli	160	27	the	the	DT
cord-265900-7lj4bfli	160	28	N	n	CD
cord-265900-7lj4bfli	160	29	-	-	HYPH
cord-265900-7lj4bfli	160	30	end	end	NN
cord-265900-7lj4bfli	160	31	rule	rule	NN
cord-265900-7lj4bfli	160	32	pathway	pathway	NN
cord-265900-7lj4bfli	160	33	Interaction	Interaction	NNP
cord-265900-7lj4bfli	160	34	with	with	IN
cord-265900-7lj4bfli	160	35	a	a	DT
cord-265900-7lj4bfli	160	36	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	160	37	-	-	HYPH
cord-265900-7lj4bfli	160	38	like	like	JJ
cord-265900-7lj4bfli	160	39	protein	protein	NN
cord-265900-7lj4bfli	160	40	enhances	enhance	VBZ
cord-265900-7lj4bfli	160	41	the	the	DT
cord-265900-7lj4bfli	160	42	ubiquitination	ubiquitination	NN
cord-265900-7lj4bfli	160	43	and	and	CC
cord-265900-7lj4bfli	160	44	degradation	degradation	NN
cord-265900-7lj4bfli	160	45	of	of	IN
cord-265900-7lj4bfli	160	46	hepatitis	hepatitis	NN
cord-265900-7lj4bfli	160	47	C	C	NNP
cord-265900-7lj4bfli	160	48	virus	virus	NN
cord-265900-7lj4bfli	160	49	RNAdependent	RNAdependent	NNP
cord-265900-7lj4bfli	160	50	RNA	RNA	NNP
cord-265900-7lj4bfli	161	1	polymerase	polymerase	NNP
cord-265900-7lj4bfli	161	2	Signals	Signals	NNPS
cord-265900-7lj4bfli	161	3	in	in	IN
cord-265900-7lj4bfli	161	4	hepatitis	hepatitis	NN
cord-265900-7lj4bfli	161	5	A	A	NNP
cord-265900-7lj4bfli	161	6	virus	virus	NN
cord-265900-7lj4bfli	161	7	P3	P3	NNP
cord-265900-7lj4bfli	161	8	region	region	NN
cord-265900-7lj4bfli	161	9	proteins	protein	NNS
cord-265900-7lj4bfli	161	10	recognized	recognize	VBN
cord-265900-7lj4bfli	161	11	by	by	IN
cord-265900-7lj4bfli	161	12	the	the	DT
cord-265900-7lj4bfli	161	13	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	161	14	-	-	HYPH
cord-265900-7lj4bfli	161	15	mediated	mediate	VBN
cord-265900-7lj4bfli	161	16	proteolytic	proteolytic	JJ
cord-265900-7lj4bfli	161	17	system	system	NN
cord-265900-7lj4bfli	161	18	Evaluation	Evaluation	NNP
cord-265900-7lj4bfli	161	19	of	of	IN
cord-265900-7lj4bfli	161	20	the	the	DT
cord-265900-7lj4bfli	161	21	susceptibility	susceptibility	NN
cord-265900-7lj4bfli	161	22	of	of	IN
cord-265900-7lj4bfli	161	23	the	the	DT
cord-265900-7lj4bfli	161	24	3C	3C	NNP
cord-265900-7lj4bfli	161	25	proteases	protease	NNS
cord-265900-7lj4bfli	161	26	of	of	IN
cord-265900-7lj4bfli	161	27	hepatitis	hepatitis	NNP
cord-265900-7lj4bfli	161	28	A	A	NNP
cord-265900-7lj4bfli	161	29	virus	virus	NN
cord-265900-7lj4bfli	161	30	and	and	CC
cord-265900-7lj4bfli	161	31	poliovirus	poliovirus	NN
cord-265900-7lj4bfli	161	32	to	to	IN
cord-265900-7lj4bfli	161	33	degradation	degradation	NN
cord-265900-7lj4bfli	161	34	by	by	IN
cord-265900-7lj4bfli	161	35	the	the	DT
cord-265900-7lj4bfli	161	36	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	161	37	-	-	HYPH
cord-265900-7lj4bfli	161	38	mediated	mediate	VBN
cord-265900-7lj4bfli	161	39	proteolytic	proteolytic	JJ
cord-265900-7lj4bfli	161	40	system	system	NN
cord-265900-7lj4bfli	161	41	Identification	identification	NN
cord-265900-7lj4bfli	161	42	and	and	CC
cord-265900-7lj4bfli	161	43	characterization	characterization	NN
cord-265900-7lj4bfli	161	44	of	of	IN
cord-265900-7lj4bfli	161	45	a	a	DT
cord-265900-7lj4bfli	161	46	protein	protein	NN
cord-265900-7lj4bfli	161	47	destruction	destruction	NN
cord-265900-7lj4bfli	161	48	signal	signal	NN
cord-265900-7lj4bfli	161	49	in	in	IN
cord-265900-7lj4bfli	161	50	the	the	DT
cord-265900-7lj4bfli	161	51	encephalomyocarditis	encephalomyocarditis	NNP
cord-265900-7lj4bfli	161	52	virus	virus	NN
cord-265900-7lj4bfli	161	53	3C	3C	NNP
cord-265900-7lj4bfli	161	54	protease	protease	NN
cord-265900-7lj4bfli	161	55	Kinetic	Kinetic	NNP
cord-265900-7lj4bfli	161	56	analysis	analysis	NN
cord-265900-7lj4bfli	161	57	of	of	IN
cord-265900-7lj4bfli	161	58	the	the	DT
cord-265900-7lj4bfli	161	59	conjugation	conjugation	NN
cord-265900-7lj4bfli	161	60	of	of	IN
cord-265900-7lj4bfli	161	61	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	161	62	to	to	IN
cord-265900-7lj4bfli	161	63	picornavirus	picornavirus	NNP
cord-265900-7lj4bfli	161	64	3C	3C	NNP
cord-265900-7lj4bfli	161	65	proteases	protease	NNS
cord-265900-7lj4bfli	161	66	catalyzed	catalyze	VBN
cord-265900-7lj4bfli	161	67	by	by	IN
cord-265900-7lj4bfli	161	68	the	the	DT
cord-265900-7lj4bfli	161	69	mammalian	mammalian	JJ
cord-265900-7lj4bfli	161	70	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	161	71	-	-	HYPH
cord-265900-7lj4bfli	161	72	protein	protein	NN
cord-265900-7lj4bfli	161	73	ligase	ligase	NN
cord-265900-7lj4bfli	161	74	E3alpha	e3alpha	NN
cord-265900-7lj4bfli	161	75	Hepatitis	hepatitis	NN
cord-265900-7lj4bfli	161	76	C	c	NN
cord-265900-7lj4bfli	161	77	:	:	:
cord-265900-7lj4bfli	162	1	virus	virus	NN
cord-265900-7lj4bfli	162	2	NS2	NS2	NNP
cord-265900-7lj4bfli	162	3	protein	protein	NN
cord-265900-7lj4bfli	162	4	is	be	VBZ
cord-265900-7lj4bfli	162	5	phosphorylated	phosphorylate	VBN
cord-265900-7lj4bfli	162	6	by	by	IN
cord-265900-7lj4bfli	162	7	the	the	DT
cord-265900-7lj4bfli	162	8	protein	protein	NN
cord-265900-7lj4bfli	162	9	kinase	kinase	NN
cord-265900-7lj4bfli	162	10	CK2	CK2	NNP
cord-265900-7lj4bfli	162	11	and	and	CC
cord-265900-7lj4bfli	162	12	targeted	target	VBN
cord-265900-7lj4bfli	162	13	for	for	IN
cord-265900-7lj4bfli	162	14	degradation	degradation	NN
cord-265900-7lj4bfli	162	15	to	to	IN
cord-265900-7lj4bfli	162	16	the	the	DT
cord-265900-7lj4bfli	162	17	proteasome	proteasome	NN
cord-265900-7lj4bfli	162	18	SOCS1	socs1	NN
cord-265900-7lj4bfli	162	19	[	[	-LRB-
cord-265900-7lj4bfli	162	20	corrected	correct	VBN
cord-265900-7lj4bfli	162	21	]	]	-RRB-
cord-265900-7lj4bfli	163	1	inhibits	inhibit	VBZ
cord-265900-7lj4bfli	163	2	HPV	hpv	NN
cord-265900-7lj4bfli	163	3	-	-	HYPH
cord-265900-7lj4bfli	163	4	E7-mediated	e7-mediate	VBN
cord-265900-7lj4bfli	163	5	transformation	transformation	NN
cord-265900-7lj4bfli	163	6	by	by	IN
cord-265900-7lj4bfli	163	7	inducing	induce	VBG
cord-265900-7lj4bfli	163	8	degradation	degradation	NN
cord-265900-7lj4bfli	163	9	of	of	IN
cord-265900-7lj4bfli	163	10	E7	E7	NNP
cord-265900-7lj4bfli	163	11	protein	protein	NN
cord-265900-7lj4bfli	164	1	The	the	DT
cord-265900-7lj4bfli	164	2	papillomavirus	papillomavirus	NN
cord-265900-7lj4bfli	164	3	E7	E7	NNP
cord-265900-7lj4bfli	164	4	oncoprotein	oncoprotein	NNP
cord-265900-7lj4bfli	164	5	is	be	VBZ
cord-265900-7lj4bfli	164	6	ubiquitinated	ubiquitinate	VBN
cord-265900-7lj4bfli	164	7	by	by	IN
cord-265900-7lj4bfli	164	8	UbcH7	UbcH7	NNP
cord-265900-7lj4bfli	164	9	and	and	CC
cord-265900-7lj4bfli	164	10	Cullin	Cullin	NNP
cord-265900-7lj4bfli	164	11	1-and	1-and	CD
cord-265900-7lj4bfli	165	1	Skp2-containing	Skp2-containing	NNP
cord-265900-7lj4bfli	165	2	E3	E3	NNP
cord-265900-7lj4bfli	165	3	ligase	ligase	NNP
cord-265900-7lj4bfli	166	1	MKRN1	MKRN1	NNP
cord-265900-7lj4bfli	166	2	induces	induce	VBZ
cord-265900-7lj4bfli	166	3	degradation	degradation	NN
cord-265900-7lj4bfli	166	4	of	of	IN
cord-265900-7lj4bfli	166	5	West	West	NNP
cord-265900-7lj4bfli	166	6	Nile	Nile	NNP
cord-265900-7lj4bfli	166	7	virus	virus	NN
cord-265900-7lj4bfli	166	8	capsid	capsid	NN
cord-265900-7lj4bfli	166	9	protein	protein	NN
cord-265900-7lj4bfli	166	10	by	by	IN
cord-265900-7lj4bfli	166	11	functioning	function	VBG
cord-265900-7lj4bfli	166	12	as	as	IN
cord-265900-7lj4bfli	167	1	an	an	DT
cord-265900-7lj4bfli	167	2	E3	e3	NN
cord-265900-7lj4bfli	167	3	ligase	ligase	NN
cord-265900-7lj4bfli	167	4	Proteasomal	Proteasomal	NNP
cord-265900-7lj4bfli	167	5	turnover	turnover	NN
cord-265900-7lj4bfli	167	6	of	of	IN
cord-265900-7lj4bfli	167	7	hepatitis	hepatitis	NN
cord-265900-7lj4bfli	167	8	C	C	NNP
cord-265900-7lj4bfli	167	9	virus	virus	NN
cord-265900-7lj4bfli	167	10	core	core	NN
cord-265900-7lj4bfli	167	11	protein	protein	NN
cord-265900-7lj4bfli	167	12	is	be	VBZ
cord-265900-7lj4bfli	167	13	regulated	regulate	VBN
cord-265900-7lj4bfli	167	14	by	by	IN
cord-265900-7lj4bfli	167	15	two	two	CD
cord-265900-7lj4bfli	167	16	distinct	distinct	JJ
cord-265900-7lj4bfli	167	17	mechanisms	mechanism	NNS
cord-265900-7lj4bfli	167	18	:	:	:
cord-265900-7lj4bfli	168	1	a	a	DT
cord-265900-7lj4bfli	168	2	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	168	3	-	-	HYPH
cord-265900-7lj4bfli	168	4	dependent	dependent	JJ
cord-265900-7lj4bfli	168	5	mechanism	mechanism	NN
cord-265900-7lj4bfli	168	6	and	and	CC
cord-265900-7lj4bfli	168	7	a	a	DT
cord-265900-7lj4bfli	168	8	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	168	9	-	-	HYPH
cord-265900-7lj4bfli	168	10	independent	independent	JJ
cord-265900-7lj4bfli	168	11	but	but	CC
cord-265900-7lj4bfli	168	12	PA28gamma	pa28gamma	JJ
cord-265900-7lj4bfli	168	13	-	-	HYPH
cord-265900-7lj4bfli	168	14	dependent	dependent	JJ
cord-265900-7lj4bfli	168	15	mechanism	mechanism	NN
cord-265900-7lj4bfli	168	16	Stability	stability	NN
cord-265900-7lj4bfli	168	17	in	in	IN
cord-265900-7lj4bfli	168	18	vitro	vitro	FW
cord-265900-7lj4bfli	168	19	of	of	IN
cord-265900-7lj4bfli	168	20	the	the	DT
cord-265900-7lj4bfli	168	21	69	69	CD
cord-265900-7lj4bfli	168	22	K	K	NNP
cord-265900-7lj4bfli	168	23	movement	movement	NN
cord-265900-7lj4bfli	168	24	protein	protein	NN
cord-265900-7lj4bfli	168	25	of	of	IN
cord-265900-7lj4bfli	168	26	Turnip	Turnip	NNP
cord-265900-7lj4bfli	168	27	yellow	yellow	JJ
cord-265900-7lj4bfli	168	28	mosaic	mosaic	JJ
cord-265900-7lj4bfli	168	29	virus	virus	NN
cord-265900-7lj4bfli	168	30	is	be	VBZ
cord-265900-7lj4bfli	168	31	regulated	regulate	VBN
cord-265900-7lj4bfli	168	32	by	by	IN
cord-265900-7lj4bfli	168	33	the	the	DT
cord-265900-7lj4bfli	168	34	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	168	35	-	-	HYPH
cord-265900-7lj4bfli	168	36	mediated	mediate	VBN
cord-265900-7lj4bfli	168	37	proteasome	proteasome	NN
cord-265900-7lj4bfli	168	38	pathway	pathway	NN
cord-265900-7lj4bfli	168	39	Degradation	degradation	NN
cord-265900-7lj4bfli	168	40	of	of	IN
cord-265900-7lj4bfli	168	41	tobacco	tobacco	NN
cord-265900-7lj4bfli	168	42	mosaic	mosaic	NNP
cord-265900-7lj4bfli	168	43	virus	virus	NN
cord-265900-7lj4bfli	168	44	movement	movement	NN
cord-265900-7lj4bfli	168	45	protein	protein	NN
cord-265900-7lj4bfli	168	46	by	by	IN
cord-265900-7lj4bfli	168	47	the	the	DT
cord-265900-7lj4bfli	168	48	26S	26S	NNP
cord-265900-7lj4bfli	168	49	proteasome	proteasome	NNP
cord-265900-7lj4bfli	169	1	The	the	DT
cord-265900-7lj4bfli	169	2	Nedd4-type	Nedd4-type	NNP
cord-265900-7lj4bfli	169	3	Rsp5p	rsp5p	NN
cord-265900-7lj4bfli	169	4	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	169	5	ligase	ligase	NN
cord-265900-7lj4bfli	169	6	inhibits	inhibit	VBZ
cord-265900-7lj4bfli	169	7	tombusvirus	tombusvirus	NN
cord-265900-7lj4bfli	169	8	replication	replication	NN
cord-265900-7lj4bfli	169	9	by	by	IN
cord-265900-7lj4bfli	169	10	regulating	regulate	VBG
cord-265900-7lj4bfli	169	11	degradation	degradation	NN
cord-265900-7lj4bfli	169	12	of	of	IN
cord-265900-7lj4bfli	169	13	the	the	DT
cord-265900-7lj4bfli	169	14	p92	p92	NN
cord-265900-7lj4bfli	169	15	replication	replication	NN
cord-265900-7lj4bfli	169	16	protein	protein	NN
cord-265900-7lj4bfli	169	17	and	and	CC
cord-265900-7lj4bfli	169	18	decreasing	decrease	VBG
cord-265900-7lj4bfli	169	19	the	the	DT
cord-265900-7lj4bfli	169	20	activity	activity	NN
cord-265900-7lj4bfli	169	21	of	of	IN
cord-265900-7lj4bfli	169	22	the	the	DT
cord-265900-7lj4bfli	169	23	tombusvirus	tombusvirus	NNP
cord-265900-7lj4bfli	169	24	replicase	replicase	NN
cord-265900-7lj4bfli	169	25	Ubiquitin	Ubiquitin	NNP
cord-265900-7lj4bfli	170	1	is	be	VBZ
cord-265900-7lj4bfli	170	2	part	part	NN
cord-265900-7lj4bfli	170	3	of	of	IN
cord-265900-7lj4bfli	170	4	the	the	DT
cord-265900-7lj4bfli	170	5	retrovirus	retrovirus	NN
cord-265900-7lj4bfli	170	6	budding	bud	VBG
cord-265900-7lj4bfli	170	7	machinery	machinery	NN
cord-265900-7lj4bfli	171	1	Proteasome	proteasome	NN
cord-265900-7lj4bfli	171	2	inhibition	inhibition	NN
cord-265900-7lj4bfli	171	3	interferes	interfere	VBZ
cord-265900-7lj4bfli	171	4	with	with	IN
cord-265900-7lj4bfli	171	5	gag	gag	NN
cord-265900-7lj4bfli	171	6	polyprotein	polyprotein	JJ
cord-265900-7lj4bfli	171	7	processing	processing	NN
cord-265900-7lj4bfli	171	8	,	,	,
cord-265900-7lj4bfli	171	9	release	release	NN
cord-265900-7lj4bfli	171	10	,	,	,
cord-265900-7lj4bfli	171	11	and	and	CC
cord-265900-7lj4bfli	171	12	maturation	maturation	NN
cord-265900-7lj4bfli	171	13	of	of	IN
cord-265900-7lj4bfli	171	14	HIV-1	HIV-1	NNP
cord-265900-7lj4bfli	171	15	and	and	CC
cord-265900-7lj4bfli	171	16	HIV-2	HIV-2	NNP
cord-265900-7lj4bfli	171	17	A	a	DT
cord-265900-7lj4bfli	171	18	role	role	NN
cord-265900-7lj4bfli	171	19	for	for	IN
cord-265900-7lj4bfli	171	20	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	171	21	ligase	ligase	NN
cord-265900-7lj4bfli	171	22	recruitment	recruitment	NN
cord-265900-7lj4bfli	171	23	in	in	IN
cord-265900-7lj4bfli	171	24	retrovirus	retrovirus	NN
cord-265900-7lj4bfli	171	25	release	release	NN
cord-265900-7lj4bfli	171	26	Sudol	Sudol	NNP
cord-265900-7lj4bfli	171	27	M	M	NNP
cord-265900-7lj4bfli	171	28	:	:	:
cord-265900-7lj4bfli	171	29	WW	WW	NNP
cord-265900-7lj4bfli	171	30	domains	domain	NNS
cord-265900-7lj4bfli	171	31	and	and	CC
cord-265900-7lj4bfli	171	32	retrovirus	retrovirus	NN
cord-265900-7lj4bfli	171	33	budding	bud	VBG
cord-265900-7lj4bfli	171	34	Proteins	protein	NNS
cord-265900-7lj4bfli	171	35	related	relate	VBN
cord-265900-7lj4bfli	171	36	to	to	IN
cord-265900-7lj4bfli	171	37	the	the	DT
cord-265900-7lj4bfli	171	38	Nedd4	nedd4	JJ
cord-265900-7lj4bfli	171	39	family	family	NN
cord-265900-7lj4bfli	171	40	of	of	IN
cord-265900-7lj4bfli	171	41	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	171	42	protein	protein	NN
cord-265900-7lj4bfli	171	43	ligases	ligase	NNS
cord-265900-7lj4bfli	171	44	interact	interact	VBP
cord-265900-7lj4bfli	171	45	with	with	IN
cord-265900-7lj4bfli	171	46	the	the	DT
cord-265900-7lj4bfli	171	47	L	L	NNP
cord-265900-7lj4bfli	171	48	domain	domain	NN
cord-265900-7lj4bfli	171	49	of	of	IN
cord-265900-7lj4bfli	171	50	Rous	rous	JJ
cord-265900-7lj4bfli	171	51	sarcoma	sarcoma	NN
cord-265900-7lj4bfli	171	52	virus	virus	NN
cord-265900-7lj4bfli	171	53	and	and	CC
cord-265900-7lj4bfli	171	54	are	be	VBP
cord-265900-7lj4bfli	171	55	required	require	VBN
cord-265900-7lj4bfli	171	56	for	for	IN
cord-265900-7lj4bfli	171	57	gag	gag	NN
cord-265900-7lj4bfli	171	58	budding	bud	VBG
cord-265900-7lj4bfli	171	59	from	from	IN
cord-265900-7lj4bfli	171	60	cells	cell	NNS
cord-265900-7lj4bfli	171	61	Overexpression	Overexpression	NNP
cord-265900-7lj4bfli	171	62	of	of	IN
cord-265900-7lj4bfli	171	63	the	the	DT
cord-265900-7lj4bfli	171	64	N	n	CD
cord-265900-7lj4bfli	171	65	-	-	HYPH
cord-265900-7lj4bfli	171	66	terminal	terminal	NN
cord-265900-7lj4bfli	171	67	domain	domain	NN
cord-265900-7lj4bfli	171	68	of	of	IN
cord-265900-7lj4bfli	171	69	TSG101	TSG101	NNP
cord-265900-7lj4bfli	171	70	inhibits	inhibit	VBZ
cord-265900-7lj4bfli	171	71	HIV-1	HIV-1	NNP
cord-265900-7lj4bfli	171	72	budding	bud	VBG
cord-265900-7lj4bfli	171	73	by	by	IN
cord-265900-7lj4bfli	171	74	blocking	block	VBG
cord-265900-7lj4bfli	171	75	late	late	JJ
cord-265900-7lj4bfli	171	76	domain	domain	NN
cord-265900-7lj4bfli	171	77	function	function	NN
cord-265900-7lj4bfli	172	1	Tsg101	Tsg101	NNP
cord-265900-7lj4bfli	172	2	and	and	CC
cord-265900-7lj4bfli	172	3	the	the	DT
cord-265900-7lj4bfli	172	4	vacuolar	vacuolar	NNP
cord-265900-7lj4bfli	172	5	protein	protein	NN
cord-265900-7lj4bfli	172	6	sorting	sort	VBG
cord-265900-7lj4bfli	172	7	pathway	pathway	NN
cord-265900-7lj4bfli	172	8	are	be	VBP
cord-265900-7lj4bfli	172	9	essential	essential	JJ
cord-265900-7lj4bfli	172	10	for	for	IN
cord-265900-7lj4bfli	172	11	HIV-1	HIV-1	NNP
cord-265900-7lj4bfli	172	12	budding	bud	VBG
cord-265900-7lj4bfli	172	13	Ubiquitination	Ubiquitination	NNP
cord-265900-7lj4bfli	172	14	of	of	IN
cord-265900-7lj4bfli	172	15	tombusvirus	tombusvirus	NNP
cord-265900-7lj4bfli	172	16	p33	p33	NNP
cord-265900-7lj4bfli	172	17	replication	replication	NN
cord-265900-7lj4bfli	172	18	protein	protein	NN
cord-265900-7lj4bfli	172	19	plays	play	VBZ
cord-265900-7lj4bfli	172	20	a	a	DT
cord-265900-7lj4bfli	172	21	role	role	NN
cord-265900-7lj4bfli	172	22	in	in	IN
cord-265900-7lj4bfli	172	23	virus	virus	NN
cord-265900-7lj4bfli	172	24	replication	replication	NN
cord-265900-7lj4bfli	172	25	and	and	CC
cord-265900-7lj4bfli	172	26	binding	bind	VBG
cord-265900-7lj4bfli	172	27	to	to	IN
cord-265900-7lj4bfli	172	28	the	the	DT
cord-265900-7lj4bfli	172	29	host	host	NN
cord-265900-7lj4bfli	172	30	Vps23p	Vps23p	NNP
cord-265900-7lj4bfli	172	31	ESCRT	ESCRT	NNP
cord-265900-7lj4bfli	172	32	protein	protein	NN
cord-265900-7lj4bfli	173	1	Cdc34p	cdc34p	DT
cord-265900-7lj4bfli	173	2	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	173	3	-	-	HYPH
cord-265900-7lj4bfli	173	4	conjugating	conjugate	VBG
cord-265900-7lj4bfli	173	5	enzyme	enzyme	NN
cord-265900-7lj4bfli	173	6	is	be	VBZ
cord-265900-7lj4bfli	173	7	a	a	DT
cord-265900-7lj4bfli	173	8	component	component	NN
cord-265900-7lj4bfli	173	9	of	of	IN
cord-265900-7lj4bfli	173	10	the	the	DT
cord-265900-7lj4bfli	173	11	tombusvirus	tombusvirus	NNP
cord-265900-7lj4bfli	173	12	replicase	replicase	NNP
cord-265900-7lj4bfli	173	13	complex	complex	NNP
cord-265900-7lj4bfli	173	14	and	and	CC
cord-265900-7lj4bfli	173	15	ubiquitinates	ubiquitinates	NNP
cord-265900-7lj4bfli	173	16	p33	p33	ADD
cord-265900-7lj4bfli	174	1	replication	replication	NN
cord-265900-7lj4bfli	174	2	protein	protein	NN
cord-265900-7lj4bfli	174	3	A	a	DT
cord-265900-7lj4bfli	174	4	non	non	JJ
cord-265900-7lj4bfli	174	5	-	-	JJ
cord-265900-7lj4bfli	174	6	proteolytic	proteolytic	JJ
cord-265900-7lj4bfli	174	7	role	role	NN
cord-265900-7lj4bfli	174	8	for	for	IN
cord-265900-7lj4bfli	174	9	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	174	10	in	in	IN
cord-265900-7lj4bfli	174	11	Tat	tat	NN
cord-265900-7lj4bfli	174	12	-	-	HYPH
cord-265900-7lj4bfli	174	13	mediated	mediate	VBN
cord-265900-7lj4bfli	174	14	transactivation	transactivation	NN
cord-265900-7lj4bfli	174	15	of	of	IN
cord-265900-7lj4bfli	174	16	the	the	DT
cord-265900-7lj4bfli	174	17	HIV-1	HIV-1	NNP
cord-265900-7lj4bfli	174	18	promoter	promoter	NN
cord-265900-7lj4bfli	174	19	Ubiquitination	Ubiquitination	NNP
cord-265900-7lj4bfli	174	20	of	of	IN
cord-265900-7lj4bfli	174	21	human	human	JJ
cord-265900-7lj4bfli	174	22	T	t	NN
cord-265900-7lj4bfli	174	23	-	-	HYPH
cord-265900-7lj4bfli	174	24	cell	cell	NN
cord-265900-7lj4bfli	174	25	leukemia	leukemia	NN
cord-265900-7lj4bfli	174	26	virus	virus	NN
cord-265900-7lj4bfli	174	27	type	type	NN
cord-265900-7lj4bfli	174	28	1	1	CD
cord-265900-7lj4bfli	174	29	tax	tax	NN
cord-265900-7lj4bfli	174	30	modulates	modulate	VBZ
cord-265900-7lj4bfli	174	31	its	-PRON-	PRP$
cord-265900-7lj4bfli	174	32	activity	activity	NN
cord-265900-7lj4bfli	175	1	Ubiquitination	Ubiquitination	NNP
cord-265900-7lj4bfli	175	2	is	be	VBZ
cord-265900-7lj4bfli	175	3	required	require	VBN
cord-265900-7lj4bfli	175	4	for	for	IN
cord-265900-7lj4bfli	175	5	effective	effective	JJ
cord-265900-7lj4bfli	175	6	replication	replication	NN
cord-265900-7lj4bfli	175	7	of	of	IN
cord-265900-7lj4bfli	175	8	coxsackievirus	coxsackievirus	NNP
cord-265900-7lj4bfli	175	9	B3	B3	NNP
cord-265900-7lj4bfli	176	1	The	the	DT
cord-265900-7lj4bfli	176	2	envelope	envelope	NN
cord-265900-7lj4bfli	176	3	protein	protein	NN
cord-265900-7lj4bfli	176	4	of	of	IN
cord-265900-7lj4bfli	176	5	severe	severe	JJ
cord-265900-7lj4bfli	176	6	acute	acute	JJ
cord-265900-7lj4bfli	176	7	respiratory	respiratory	JJ
cord-265900-7lj4bfli	176	8	syndrome	syndrome	NN
cord-265900-7lj4bfli	176	9	coronavirus	coronavirus	NN
cord-265900-7lj4bfli	176	10	interacts	interact	VBZ
cord-265900-7lj4bfli	176	11	with	with	IN
cord-265900-7lj4bfli	176	12	the	the	DT
cord-265900-7lj4bfli	176	13	non	non	JJ
cord-265900-7lj4bfli	176	14	-	-	JJ
cord-265900-7lj4bfli	176	15	structural	structural	JJ
cord-265900-7lj4bfli	176	16	protein	protein	NN
cord-265900-7lj4bfli	176	17	3	3	CD
cord-265900-7lj4bfli	176	18	and	and	CC
cord-265900-7lj4bfli	176	19	is	be	VBZ
cord-265900-7lj4bfli	176	20	ubiquitinated	ubiquitinate	VBN
cord-265900-7lj4bfli	176	21	Ubiquitinated	Ubiquitinated	NNP
cord-265900-7lj4bfli	176	22	conjugates	conjugate	NNS
cord-265900-7lj4bfli	176	23	are	be	VBP
cord-265900-7lj4bfli	176	24	found	find	VBN
cord-265900-7lj4bfli	176	25	in	in	IN
cord-265900-7lj4bfli	176	26	preparations	preparation	NNS
cord-265900-7lj4bfli	176	27	of	of	IN
cord-265900-7lj4bfli	176	28	several	several	JJ
cord-265900-7lj4bfli	176	29	plant	plant	NN
cord-265900-7lj4bfli	176	30	viruses	virus	NNS
cord-265900-7lj4bfli	176	31	Evaluation	Evaluation	NNP
cord-265900-7lj4bfli	176	32	of	of	IN
cord-265900-7lj4bfli	176	33	interactions	interaction	NNS
cord-265900-7lj4bfli	176	34	of	of	IN
cord-265900-7lj4bfli	176	35	human	human	JJ
cord-265900-7lj4bfli	176	36	cytomegalovirus	cytomegalovirus	NN
cord-265900-7lj4bfli	176	37	immediate	immediate	JJ
cord-265900-7lj4bfli	176	38	-	-	HYPH
cord-265900-7lj4bfli	176	39	early	early	JJ
cord-265900-7lj4bfli	176	40	IE2	ie2	JJ
cord-265900-7lj4bfli	176	41	regulatory	regulatory	JJ
cord-265900-7lj4bfli	176	42	protein	protein	NN
cord-265900-7lj4bfli	176	43	with	with	IN
cord-265900-7lj4bfli	176	44	small	small	JJ
cord-265900-7lj4bfli	176	45	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	176	46	-	-	HYPH
cord-265900-7lj4bfli	176	47	like	like	JJ
cord-265900-7lj4bfli	176	48	modifiers	modifier	NNS
cord-265900-7lj4bfli	176	49	and	and	CC
cord-265900-7lj4bfli	176	50	their	-PRON-	PRP$
cord-265900-7lj4bfli	176	51	conjugation	conjugation	NN
cord-265900-7lj4bfli	176	52	enzyme	enzyme	NN
cord-265900-7lj4bfli	176	53	Ubc9	Ubc9	NNP
cord-265900-7lj4bfli	176	54	SUMO-1	sumo-1	JJ
cord-265900-7lj4bfli	176	55	modification	modification	NN
cord-265900-7lj4bfli	176	56	of	of	IN
cord-265900-7lj4bfli	176	57	human	human	JJ
cord-265900-7lj4bfli	176	58	cytomegalovirus	cytomegalovirus	NNP
cord-265900-7lj4bfli	176	59	IE1	IE1	NNP
cord-265900-7lj4bfli	176	60	/	/	SYM
cord-265900-7lj4bfli	176	61	IE72	IE72	NNP
cord-265900-7lj4bfli	176	62	SUMOylation	sumoylation	NN
cord-265900-7lj4bfli	176	63	of	of	IN
cord-265900-7lj4bfli	176	64	the	the	DT
cord-265900-7lj4bfli	176	65	human	human	JJ
cord-265900-7lj4bfli	176	66	cytomegalovirus	cytomegalovirus	NNP
cord-265900-7lj4bfli	176	67	72-kilodalton	72-kilodalton	CD
cord-265900-7lj4bfli	176	68	IE1	IE1	NNP
cord-265900-7lj4bfli	176	69	protein	protein	NN
cord-265900-7lj4bfli	177	1	facilitates	facilitate	VBZ
cord-265900-7lj4bfli	177	2	expression	expression	NN
cord-265900-7lj4bfli	177	3	of	of	IN
cord-265900-7lj4bfli	177	4	the	the	DT
cord-265900-7lj4bfli	177	5	86-kilodalton	86-kilodalton	CD
cord-265900-7lj4bfli	177	6	IE2	ie2	NN
cord-265900-7lj4bfli	177	7	protein	protein	NN
cord-265900-7lj4bfli	177	8	and	and	CC
cord-265900-7lj4bfli	177	9	promotes	promote	VBZ
cord-265900-7lj4bfli	177	10	viral	viral	JJ
cord-265900-7lj4bfli	177	11	replication	replication	NN
cord-265900-7lj4bfli	177	12	SUMO-1	sumo-1	NN
cord-265900-7lj4bfli	177	13	modification	modification	NN
cord-265900-7lj4bfli	177	14	required	require	VBN
cord-265900-7lj4bfli	177	15	for	for	IN
cord-265900-7lj4bfli	177	16	transformation	transformation	NN
cord-265900-7lj4bfli	177	17	by	by	IN
cord-265900-7lj4bfli	177	18	adenovirus	adenovirus	NN
cord-265900-7lj4bfli	177	19	type	type	NN
cord-265900-7lj4bfli	177	20	5	5	CD
cord-265900-7lj4bfli	177	21	early	early	JJ
cord-265900-7lj4bfli	177	22	region	region	NN
cord-265900-7lj4bfli	177	23	1B	1b	CD
cord-265900-7lj4bfli	177	24	55-kDa	55-kda	CD
cord-265900-7lj4bfli	178	1	oncoprotein	oncoprotein	NNP
cord-265900-7lj4bfli	178	2	Cross	Cross	NNP
cord-265900-7lj4bfli	178	3	-	-	HYPH
cord-265900-7lj4bfli	178	4	talk	talk	NN
cord-265900-7lj4bfli	178	5	between	between	IN
cord-265900-7lj4bfli	178	6	phosphorylation	phosphorylation	NN
cord-265900-7lj4bfli	178	7	and	and	CC
cord-265900-7lj4bfli	178	8	SUMOylation	sumoylation	NN
cord-265900-7lj4bfli	178	9	regulates	regulate	VBZ
cord-265900-7lj4bfli	178	10	transforming	transform	VBG
cord-265900-7lj4bfli	178	11	activities	activity	NNS
cord-265900-7lj4bfli	178	12	of	of	IN
cord-265900-7lj4bfli	178	13	an	an	DT
cord-265900-7lj4bfli	178	14	adenoviral	adenoviral	JJ
cord-265900-7lj4bfli	178	15	oncoprotein	oncoprotein	FW
cord-265900-7lj4bfli	178	16	Bovine	bovine	JJ
cord-265900-7lj4bfli	178	17	papillomavirus	papillomavirus	NN
cord-265900-7lj4bfli	178	18	E1	e1	NN
cord-265900-7lj4bfli	178	19	protein	protein	NN
cord-265900-7lj4bfli	178	20	is	be	VBZ
cord-265900-7lj4bfli	178	21	sumoylated	sumoylate	VBN
cord-265900-7lj4bfli	178	22	by	by	IN
cord-265900-7lj4bfli	178	23	the	the	DT
cord-265900-7lj4bfli	178	24	host	host	NN
cord-265900-7lj4bfli	178	25	cell	cell	NN
cord-265900-7lj4bfli	179	1	Ubc9	Ubc9	NNP
cord-265900-7lj4bfli	179	2	protein	protein	NN
cord-265900-7lj4bfli	179	3	Proteins	protein	NNS
cord-265900-7lj4bfli	179	4	of	of	IN
cord-265900-7lj4bfli	179	5	the	the	DT
cord-265900-7lj4bfli	179	6	PIAS	PIAS	NNP
cord-265900-7lj4bfli	179	7	family	family	NN
cord-265900-7lj4bfli	179	8	enhance	enhance	VB
cord-265900-7lj4bfli	179	9	the	the	DT
cord-265900-7lj4bfli	179	10	sumoylation	sumoylation	NN
cord-265900-7lj4bfli	179	11	of	of	IN
cord-265900-7lj4bfli	179	12	the	the	DT
cord-265900-7lj4bfli	179	13	papillomavirus	papillomavirus	NN
cord-265900-7lj4bfli	179	14	E1	e1	NN
cord-265900-7lj4bfli	179	15	protein	protein	NN
cord-265900-7lj4bfli	179	16	Interaction	Interaction	NNP
cord-265900-7lj4bfli	179	17	between	between	IN
cord-265900-7lj4bfli	179	18	a	a	DT
cord-265900-7lj4bfli	179	19	geminivirus	geminivirus	NNP
cord-265900-7lj4bfli	179	20	replication	replication	NN
cord-265900-7lj4bfli	179	21	protein	protein	NN
cord-265900-7lj4bfli	179	22	and	and	CC
cord-265900-7lj4bfli	179	23	the	the	DT
cord-265900-7lj4bfli	179	24	plant	plant	NN
cord-265900-7lj4bfli	179	25	sumoylation	sumoylation	NN
cord-265900-7lj4bfli	179	26	system	system	NN
cord-265900-7lj4bfli	179	27	SCE1	SCE1	NNP
cord-265900-7lj4bfli	179	28	,	,	,
cord-265900-7lj4bfli	179	29	the	the	DT
cord-265900-7lj4bfli	179	30	SUMO	SUMO	NNP
cord-265900-7lj4bfli	179	31	-	-	HYPH
cord-265900-7lj4bfli	179	32	conjugating	conjugate	VBG
cord-265900-7lj4bfli	179	33	enzyme	enzyme	NN
cord-265900-7lj4bfli	179	34	in	in	IN
cord-265900-7lj4bfli	179	35	plants	plant	NNS
cord-265900-7lj4bfli	179	36	that	that	WDT
cord-265900-7lj4bfli	179	37	interacts	interact	VBZ
cord-265900-7lj4bfli	179	38	with	with	IN
cord-265900-7lj4bfli	179	39	NIb	NIb	NNS
cord-265900-7lj4bfli	179	40	,	,	,
cord-265900-7lj4bfli	179	41	the	the	DT
cord-265900-7lj4bfli	179	42	RNA	RNA	NNP
cord-265900-7lj4bfli	179	43	-	-	HYPH
cord-265900-7lj4bfli	179	44	dependent	dependent	JJ
cord-265900-7lj4bfli	179	45	RNA	RNA	NNP
cord-265900-7lj4bfli	179	46	polymerase	polymerase	NN
cord-265900-7lj4bfli	179	47	of	of	IN
cord-265900-7lj4bfli	179	48	Turnip	Turnip	NNP
cord-265900-7lj4bfli	179	49	mosaic	mosaic	JJ
cord-265900-7lj4bfli	179	50	virus	virus	NN
cord-265900-7lj4bfli	179	51	,	,	,
cord-265900-7lj4bfli	179	52	is	be	VBZ
cord-265900-7lj4bfli	179	53	required	require	VBN
cord-265900-7lj4bfli	179	54	for	for	IN
cord-265900-7lj4bfli	179	55	viral	viral	JJ
cord-265900-7lj4bfli	179	56	infection	infection	NN
cord-265900-7lj4bfli	179	57	This	this	DT
cord-265900-7lj4bfli	179	58	paper	paper	NN
cord-265900-7lj4bfli	179	59	demonstrated	demonstrate	VBD
cord-265900-7lj4bfli	179	60	that	that	IN
cord-265900-7lj4bfli	179	61	post	post	JJ
cord-265900-7lj4bfli	179	62	-	-	JJ
cord-265900-7lj4bfli	179	63	translational	translational	JJ
cord-265900-7lj4bfli	179	64	modification	modification	NN
cord-265900-7lj4bfli	179	65	of	of	IN
cord-265900-7lj4bfli	179	66	the	the	DT
cord-265900-7lj4bfli	179	67	RNAdependent	RNAdependent	NNP
cord-265900-7lj4bfli	179	68	RNA	RNA	NNP
cord-265900-7lj4bfli	179	69	polymerase	polymerase	NN
cord-265900-7lj4bfli	179	70	of	of	IN
cord-265900-7lj4bfli	179	71	turnip	turnip	NN
cord-265900-7lj4bfli	179	72	mosaic	mosaic	JJ
cord-265900-7lj4bfli	179	73	virus	virus	NN
cord-265900-7lj4bfli	179	74	by	by	IN
cord-265900-7lj4bfli	179	75	SUMO	SUMO	NNP
cord-265900-7lj4bfli	179	76	enhances	enhance	VBZ
cord-265900-7lj4bfli	179	77	viral	viral	JJ
cord-265900-7lj4bfli	179	78	infectivity	infectivity	NN
cord-265900-7lj4bfli	179	79	The	the	DT
cord-265900-7lj4bfli	179	80	antiviral	antiviral	JJ
cord-265900-7lj4bfli	179	81	activities	activity	NNS
cord-265900-7lj4bfli	179	82	of	of	IN
cord-265900-7lj4bfli	179	83	ISG15	isg15	NN
cord-265900-7lj4bfli	180	1	This	this	DT
cord-265900-7lj4bfli	180	2	review	review	NN
cord-265900-7lj4bfli	180	3	summarized	summarize	VBD
cord-265900-7lj4bfli	180	4	the	the	DT
cord-265900-7lj4bfli	180	5	functional	functional	JJ
cord-265900-7lj4bfli	180	6	role	role	NN
cord-265900-7lj4bfli	180	7	of	of	IN
cord-265900-7lj4bfli	180	8	the	the	DT
cord-265900-7lj4bfli	180	9	ISG15	isg15	NN
cord-265900-7lj4bfli	180	10	in	in	IN
cord-265900-7lj4bfli	180	11	regulating	regulate	VBG
cord-265900-7lj4bfli	180	12	immune	immune	JJ
cord-265900-7lj4bfli	180	13	response	response	NN
cord-265900-7lj4bfli	180	14	against	against	IN
cord-265900-7lj4bfli	180	15	viral	viral	JJ
cord-265900-7lj4bfli	180	16	infection	infection	NN
cord-265900-7lj4bfli	180	17	and	and	CC
cord-265900-7lj4bfli	180	18	discussed	discuss	VBD
cord-265900-7lj4bfli	180	19	the	the	DT
cord-265900-7lj4bfli	180	20	current	current	JJ
cord-265900-7lj4bfli	180	21	understanding	understanding	NN
cord-265900-7lj4bfli	180	22	of	of	IN
cord-265900-7lj4bfli	180	23	how	how	WRB
cord-265900-7lj4bfli	180	24	viruses	virus	NNS
cord-265900-7lj4bfli	180	25	have	have	VBP
cord-265900-7lj4bfli	180	26	evolved	evolve	VBN
cord-265900-7lj4bfli	180	27	to	to	TO
cord-265900-7lj4bfli	180	28	interfere	interfere	VB
cord-265900-7lj4bfli	180	29	with	with	IN
cord-265900-7lj4bfli	180	30	the	the	DT
cord-265900-7lj4bfli	180	31	ISG15	ISG15	NNP
cord-265900-7lj4bfli	180	32	pathway	pathway	NN
cord-265900-7lj4bfli	180	33	and	and	CC
cord-265900-7lj4bfli	180	34	the	the	DT
cord-265900-7lj4bfli	180	35	mechanisms	mechanism	NNS
cord-265900-7lj4bfli	180	36	involved	involve	VBD
cord-265900-7lj4bfli	180	37	Virgin	Virgin	NNP
cord-265900-7lj4bfli	180	38	HW	HW	NNP
cord-265900-7lj4bfli	180	39	:	:	:
cord-265900-7lj4bfli	181	1	ISG15	ISG15	NNP
cord-265900-7lj4bfli	181	2	Arg151	Arg151	.
cord-265900-7lj4bfli	182	1	and	and	CC
cord-265900-7lj4bfli	182	2	the	the	DT
cord-265900-7lj4bfli	182	3	ISG15-conjugating	isg15-conjugating	NN
cord-265900-7lj4bfli	182	4	enzyme	enzyme	NN
cord-265900-7lj4bfli	182	5	UbE1L	UbE1L	NNP
cord-265900-7lj4bfli	182	6	are	be	VBP
cord-265900-7lj4bfli	182	7	important	important	JJ
cord-265900-7lj4bfli	182	8	for	for	IN
cord-265900-7lj4bfli	182	9	innate	innate	JJ
cord-265900-7lj4bfli	182	10	immune	immune	JJ
cord-265900-7lj4bfli	182	11	control	control	NN
cord-265900-7lj4bfli	182	12	of	of	IN
cord-265900-7lj4bfli	182	13	Sindbis	Sindbis	NNP
cord-265900-7lj4bfli	182	14	virus	virus	NN
cord-265900-7lj4bfli	182	15	Mice	mouse	NNS
cord-265900-7lj4bfli	182	16	lacking	lack	VBG
cord-265900-7lj4bfli	182	17	the	the	DT
cord-265900-7lj4bfli	182	18	ISG15	ISG15	NNP
cord-265900-7lj4bfli	182	19	E1	e1	NN
cord-265900-7lj4bfli	182	20	enzyme	enzyme	NN
cord-265900-7lj4bfli	182	21	UbE1L	UbE1L	NNP
cord-265900-7lj4bfli	182	22	demonstrate	demonstrate	VB
cord-265900-7lj4bfli	182	23	increased	increase	VBN
cord-265900-7lj4bfli	182	24	susceptibility	susceptibility	NN
cord-265900-7lj4bfli	182	25	to	to	IN
cord-265900-7lj4bfli	182	26	both	both	DT
cord-265900-7lj4bfli	182	27	mouse	mouse	NN
cord-265900-7lj4bfli	182	28	-	-	HYPH
cord-265900-7lj4bfli	182	29	adapted	adapt	VBN
cord-265900-7lj4bfli	182	30	and	and	CC
cord-265900-7lj4bfli	182	31	non	non	JJ
cord-265900-7lj4bfli	182	32	-	-	JJ
cord-265900-7lj4bfli	182	33	mouse	mouse	NN
cord-265900-7lj4bfli	182	34	-	-	HYPH
cord-265900-7lj4bfli	182	35	adapted	adapt	VBN
cord-265900-7lj4bfli	182	36	influenza	influenza	NN
cord-265900-7lj4bfli	182	37	B	b	NN
cord-265900-7lj4bfli	182	38	virus	virus	NN
cord-265900-7lj4bfli	182	39	infection	infection	NN
cord-265900-7lj4bfli	182	40	IFNstimulated	ifnstimulate	VBN
cord-265900-7lj4bfli	182	41	gene	gene	NN
cord-265900-7lj4bfli	182	42	15	15	CD
cord-265900-7lj4bfli	182	43	functions	function	NNS
cord-265900-7lj4bfli	182	44	as	as	IN
cord-265900-7lj4bfli	182	45	a	a	DT
cord-265900-7lj4bfli	182	46	critical	critical	JJ
cord-265900-7lj4bfli	182	47	antiviral	antiviral	JJ
cord-265900-7lj4bfli	182	48	molecule	molecule	NN
cord-265900-7lj4bfli	182	49	against	against	IN
cord-265900-7lj4bfli	182	50	influenza	influenza	NN
cord-265900-7lj4bfli	182	51	,	,	,
cord-265900-7lj4bfli	182	52	herpes	herpe	NNS
cord-265900-7lj4bfli	182	53	,	,	,
cord-265900-7lj4bfli	182	54	and	and	CC
cord-265900-7lj4bfli	182	55	Sindbis	Sindbis	NNP
cord-265900-7lj4bfli	182	56	viruses	virus	NNS
cord-265900-7lj4bfli	183	1	Innate	innate	JJ
cord-265900-7lj4bfli	183	2	antiviral	antiviral	JJ
cord-265900-7lj4bfli	183	3	response	response	NN
cord-265900-7lj4bfli	183	4	targets	target	NNS
cord-265900-7lj4bfli	183	5	HIV-1	HIV-1	NNP
cord-265900-7lj4bfli	183	6	release	release	NN
cord-265900-7lj4bfli	183	7	by	by	IN
cord-265900-7lj4bfli	183	8	the	the	DT
cord-265900-7lj4bfli	183	9	induction	induction	NN
cord-265900-7lj4bfli	183	10	of	of	IN
cord-265900-7lj4bfli	183	11	ubiquitin	ubiquitin	JJ
cord-265900-7lj4bfli	183	12	-	-	HYPH
cord-265900-7lj4bfli	183	13	like	like	JJ
cord-265900-7lj4bfli	183	14	protein	protein	NN
cord-265900-7lj4bfli	184	1	ISG15	ISG15	NNP
cord-265900-7lj4bfli	184	2	ISG15	ISG15	NNP
cord-265900-7lj4bfli	184	3	inhibits	inhibit	VBZ
cord-265900-7lj4bfli	184	4	Ebola	Ebola	NNP
cord-265900-7lj4bfli	184	5	VP40	VP40	NNP
cord-265900-7lj4bfli	184	6	VLP	VLP	NNP
cord-265900-7lj4bfli	184	7	budding	bud	VBG
cord-265900-7lj4bfli	184	8	in	in	IN
cord-265900-7lj4bfli	184	9	an	an	DT
cord-265900-7lj4bfli	184	10	L	l	NN
cord-265900-7lj4bfli	184	11	-	-	HYPH
cord-265900-7lj4bfli	184	12	domain	domain	NN
cord-265900-7lj4bfli	184	13	-	-	HYPH
cord-265900-7lj4bfli	184	14	dependent	dependent	JJ
cord-265900-7lj4bfli	184	15	manner	manner	NN
cord-265900-7lj4bfli	184	16	by	by	IN
cord-265900-7lj4bfli	184	17	blocking	block	VBG
cord-265900-7lj4bfli	184	18	Nedd4	nedd4	JJ
cord-265900-7lj4bfli	184	19	ligase	ligase	NN
cord-265900-7lj4bfli	184	20	activity	activity	NN
cord-265900-7lj4bfli	184	21	ISG15	isg15	NN
cord-265900-7lj4bfli	184	22	conjugation	conjugation	NN
cord-265900-7lj4bfli	184	23	system	system	NN
cord-265900-7lj4bfli	184	24	targets	target	VBZ
cord-265900-7lj4bfli	184	25	the	the	DT
cord-265900-7lj4bfli	184	26	viral	viral	JJ
cord-265900-7lj4bfli	184	27	NS1	ns1	NN
cord-265900-7lj4bfli	184	28	protein	protein	NN
cord-265900-7lj4bfli	184	29	in	in	IN
cord-265900-7lj4bfli	184	30	influenza	influenza	NN
cord-265900-7lj4bfli	184	31	A	a	DT
cord-265900-7lj4bfli	184	32	virus	virus	NN
cord-265900-7lj4bfli	184	33	-	-	HYPH
cord-265900-7lj4bfli	184	34	infected	infect	VBN
cord-265900-7lj4bfli	184	35	cells	cell	NNS
cord-265900-7lj4bfli	185	1	The	the	DT
cord-265900-7lj4bfli	185	2	ISG15	ISG15	NNP
cord-265900-7lj4bfli	185	3	conjugation	conjugation	NN
cord-265900-7lj4bfli	185	4	system	system	NN
cord-265900-7lj4bfli	185	5	broadly	broadly	RB
cord-265900-7lj4bfli	185	6	targets	target	VBZ
cord-265900-7lj4bfli	185	7	newly	newly	RB
cord-265900-7lj4bfli	185	8	synthesized	synthesize	VBN
cord-265900-7lj4bfli	185	9	proteins	protein	NNS
cord-265900-7lj4bfli	185	10	:	:	:
cord-265900-7lj4bfli	185	11	implications	implication	NNS
cord-265900-7lj4bfli	185	12	for	for	IN
cord-265900-7lj4bfli	185	13	the	the	DT
cord-265900-7lj4bfli	185	14	antiviral	antiviral	JJ
cord-265900-7lj4bfli	185	15	function	function	NN
cord-265900-7lj4bfli	185	16	of	of	IN
cord-265900-7lj4bfli	185	17	ISG15	isg15	NN
cord-265900-7lj4bfli	186	1	Ubiquitinlike	Ubiquitinlike	NNP
cord-265900-7lj4bfli	186	2	protein	protein	NN
cord-265900-7lj4bfli	187	1	ISG15	ISG15	NNP
cord-265900-7lj4bfli	187	2	(	(	-LRB-
cord-265900-7lj4bfli	187	3	interferon	interferon	NN
cord-265900-7lj4bfli	187	4	-	-	HYPH
cord-265900-7lj4bfli	187	5	stimulated	stimulate	VBN
cord-265900-7lj4bfli	187	6	gene	gene	NN
cord-265900-7lj4bfli	187	7	of	of	IN
cord-265900-7lj4bfli	187	8	15	15	CD
cord-265900-7lj4bfli	187	9	kDa	kDa	NNP
cord-265900-7lj4bfli	187	10	)	)	-RRB-
cord-265900-7lj4bfli	187	11	in	in	IN
cord-265900-7lj4bfli	187	12	host	host	NN
cord-265900-7lj4bfli	187	13	defense	defense	NN
cord-265900-7lj4bfli	187	14	against	against	IN
cord-265900-7lj4bfli	187	15	heart	heart	NN
cord-265900-7lj4bfli	187	16	failure	failure	NN
cord-265900-7lj4bfli	187	17	in	in	IN
cord-265900-7lj4bfli	187	18	a	a	DT
cord-265900-7lj4bfli	187	19	mouse	mouse	NN
cord-265900-7lj4bfli	187	20	model	model	NN
cord-265900-7lj4bfli	187	21	of	of	IN
cord-265900-7lj4bfli	187	22	virus	virus	NN
cord-265900-7lj4bfli	187	23	-	-	HYPH
cord-265900-7lj4bfli	187	24	induced	induce	VBN
cord-265900-7lj4bfli	187	25	cardiomyopathy	cardiomyopathy	NN
cord-265900-7lj4bfli	187	26	This	this	DT
cord-265900-7lj4bfli	187	27	study	study	NN
cord-265900-7lj4bfli	187	28	demonstrated	demonstrate	VBD
cord-265900-7lj4bfli	187	29	that	that	IN
cord-265900-7lj4bfli	187	30	ISG15	ISG15	NNP
cord-265900-7lj4bfli	187	31	is	be	VBZ
cord-265900-7lj4bfli	187	32	induced	induce	VBN
cord-265900-7lj4bfli	187	33	in	in	IN
cord-265900-7lj4bfli	187	34	patients	patient	NNS
cord-265900-7lj4bfli	187	35	with	with	IN
cord-265900-7lj4bfli	187	36	viral	viral	JJ
cord-265900-7lj4bfli	187	37	cardiomyopathy	cardiomyopathy	NN
cord-265900-7lj4bfli	187	38	and	and	CC
cord-265900-7lj4bfli	187	39	mice	mouse	NNS
cord-265900-7lj4bfli	187	40	with	with	IN
cord-265900-7lj4bfli	187	41	ISG15	isg15	NN
cord-265900-7lj4bfli	187	42	knockout	knockout	NN
cord-265900-7lj4bfli	187	43	develop	develop	VB
cord-265900-7lj4bfli	187	44	severe	severe	JJ
cord-265900-7lj4bfli	187	45	myocarditis	myocarditis	NN
cord-265900-7lj4bfli	187	46	and	and	CC
cord-265900-7lj4bfli	187	47	have	have	VB
cord-265900-7lj4bfli	187	48	a	a	DT
cord-265900-7lj4bfli	187	49	significant	significant	JJ
cord-265900-7lj4bfli	187	50	increase	increase	NN
cord-265900-7lj4bfli	187	51	in	in	IN
cord-265900-7lj4bfli	187	52	viral	viral	JJ
cord-265900-7lj4bfli	187	53	titers	titer	NNS
cord-265900-7lj4bfli	187	54	and	and	CC
cord-265900-7lj4bfli	187	55	mortality	mortality	NN
cord-265900-7lj4bfli	187	56	Interplay	interplay	NN
cord-265900-7lj4bfli	187	57	between	between	IN
cord-265900-7lj4bfli	187	58	viruses	virus	NNS
cord-265900-7lj4bfli	187	59	and	and	CC
cord-265900-7lj4bfli	187	60	host	host	NN
cord-265900-7lj4bfli	187	61	sumoylation	sumoylation	NN
cord-265900-7lj4bfli	187	62	pathways	pathway	NNS
cord-265900-7lj4bfli	188	1	Viral	viral	JJ
cord-265900-7lj4bfli	188	2	evasion	evasion	NN
cord-265900-7lj4bfli	188	3	mechanisms	mechanism	NNS
cord-265900-7lj4bfli	188	4	of	of	IN
cord-265900-7lj4bfli	188	5	early	early	JJ
cord-265900-7lj4bfli	188	6	antiviral	antiviral	JJ
cord-265900-7lj4bfli	188	7	responses	response	NNS
cord-265900-7lj4bfli	188	8	involving	involve	VBG
cord-265900-7lj4bfli	188	9	regulation	regulation	NN
cord-265900-7lj4bfli	188	10	of	of	IN
cord-265900-7lj4bfli	188	11	ubiquitin	ubiquitin	JJ
cord-265900-7lj4bfli	188	12	pathways	pathway	NNS
cord-265900-7lj4bfli	189	1	This	this	DT
cord-265900-7lj4bfli	189	2	review	review	NN
cord-265900-7lj4bfli	189	3	discussed	discuss	VBD
cord-265900-7lj4bfli	189	4	the	the	DT
cord-265900-7lj4bfli	189	5	role	role	NN
cord-265900-7lj4bfli	189	6	of	of	IN
cord-265900-7lj4bfli	189	7	post	post	JJ
cord-265900-7lj4bfli	189	8	-	-	JJ
cord-265900-7lj4bfli	189	9	translational	translational	JJ
cord-265900-7lj4bfli	189	10	modification	modification	NN
cord-265900-7lj4bfli	189	11	by	by	IN
cord-265900-7lj4bfli	189	12	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	189	13	in	in	IN
cord-265900-7lj4bfli	189	14	regulating	regulate	VBG
cord-265900-7lj4bfli	189	15	the	the	DT
cord-265900-7lj4bfli	189	16	stability	stability	NN
cord-265900-7lj4bfli	189	17	,	,	,
cord-265900-7lj4bfli	189	18	activity	activity	NN
cord-265900-7lj4bfli	189	19	,	,	,
cord-265900-7lj4bfli	189	20	and	and	CC
cord-265900-7lj4bfli	189	21	subcellular	subcellular	JJ
cord-265900-7lj4bfli	189	22	localization	localization	NN
cord-265900-7lj4bfli	189	23	of	of	IN
cord-265900-7lj4bfli	189	24	key	key	JJ
cord-265900-7lj4bfli	189	25	signaling	signal	VBG
cord-265900-7lj4bfli	189	26	molecules	molecule	NNS
cord-265900-7lj4bfli	189	27	involved	involve	VBN
cord-265900-7lj4bfli	189	28	in	in	IN
cord-265900-7lj4bfli	189	29	the	the	DT
cord-265900-7lj4bfli	189	30	host	host	NN
cord-265900-7lj4bfli	189	31	anti	anti	JJ
cord-265900-7lj4bfli	189	32	-	-	JJ
cord-265900-7lj4bfli	189	33	viral	viral	JJ
cord-265900-7lj4bfli	189	34	immunity	immunity	NN
cord-265900-7lj4bfli	189	35	and	and	CC
cord-265900-7lj4bfli	189	36	how	how	WRB
cord-265900-7lj4bfli	189	37	viruses	virus	NNS
cord-265900-7lj4bfli	189	38	have	have	VBP
cord-265900-7lj4bfli	189	39	evolved	evolve	VBN
cord-265900-7lj4bfli	189	40	various	various	JJ
cord-265900-7lj4bfli	189	41	mechanisms	mechanism	NNS
cord-265900-7lj4bfli	189	42	to	to	TO
cord-265900-7lj4bfli	189	43	counteract	counteract	VB
cord-265900-7lj4bfli	189	44	these	these	DT
cord-265900-7lj4bfli	189	45	innate	innate	JJ
cord-265900-7lj4bfli	189	46	anti	anti	JJ
cord-265900-7lj4bfli	189	47	-	-	JJ
cord-265900-7lj4bfli	189	48	viral	viral	JJ
cord-265900-7lj4bfli	189	49	immune	immune	JJ
cord-265900-7lj4bfli	189	50	responses	response	NNS
cord-265900-7lj4bfli	189	51	Herpes	Herpes	NNP
cord-265900-7lj4bfli	189	52	simplex	simplex	NN
cord-265900-7lj4bfli	189	53	virus	virus	NN
cord-265900-7lj4bfli	189	54	1	1	CD
cord-265900-7lj4bfli	189	55	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	189	56	-	-	HYPH
cord-265900-7lj4bfli	189	57	specific	specific	JJ
cord-265900-7lj4bfli	189	58	protease	protease	NN
cord-265900-7lj4bfli	190	1	UL36	UL36	NNP
cord-265900-7lj4bfli	190	2	inhibits	inhibit	VBZ
cord-265900-7lj4bfli	190	3	beta	beta	NN
cord-265900-7lj4bfli	190	4	interferon	interferon	NN
cord-265900-7lj4bfli	190	5	production	production	NN
cord-265900-7lj4bfli	190	6	by	by	IN
cord-265900-7lj4bfli	190	7	deubiquitinating	deubiquitinate	VBG
cord-265900-7lj4bfli	191	1	TRAF3	TRAF3	NNP
cord-265900-7lj4bfli	192	1	This	this	DT
cord-265900-7lj4bfli	192	2	article	article	NN
cord-265900-7lj4bfli	192	3	showed	show	VBD
cord-265900-7lj4bfli	192	4	that	that	IN
cord-265900-7lj4bfli	192	5	the	the	DT
cord-265900-7lj4bfli	192	6	UL36	UL36	NNP
cord-265900-7lj4bfli	192	7	protein	protein	NN
cord-265900-7lj4bfli	192	8	of	of	IN
cord-265900-7lj4bfli	192	9	herpes	herpes	NNP
cord-265900-7lj4bfli	192	10	simplex	simplex	NNP
cord-265900-7lj4bfli	192	11	virus	virus	NN
cord-265900-7lj4bfli	192	12	1	1	CD
cord-265900-7lj4bfli	192	13	acts	act	VBZ
cord-265900-7lj4bfli	192	14	as	as	IN
cord-265900-7lj4bfli	192	15	a	a	DT
cord-265900-7lj4bfli	192	16	deubiquitinating	deubiquitinating	NN
cord-265900-7lj4bfli	192	17	enzyme	enzyme	NN
cord-265900-7lj4bfli	192	18	that	that	WDT
cord-265900-7lj4bfli	192	19	removes	remove	VBZ
cord-265900-7lj4bfli	192	20	polyubiquitin	polyubiquitin	NNP
cord-265900-7lj4bfli	192	21	chains	chain	NNS
cord-265900-7lj4bfli	192	22	on	on	IN
cord-265900-7lj4bfli	192	23	TRAF3	TRAF3	NNP
cord-265900-7lj4bfli	192	24	and	and	CC
cord-265900-7lj4bfli	192	25	consequently	consequently	RB
cord-265900-7lj4bfli	192	26	inhibits	inhibit	VBZ
cord-265900-7lj4bfli	192	27	IFN	IFN	NNP
cord-265900-7lj4bfli	192	28	-	-	HYPH
cord-265900-7lj4bfli	192	29	b	b	NN
cord-265900-7lj4bfli	192	30	production	production	NN
cord-265900-7lj4bfli	192	31	Inhibition	inhibition	NN
cord-265900-7lj4bfli	192	32	of	of	IN
cord-265900-7lj4bfli	192	33	RIG	rig	NN
cord-265900-7lj4bfli	193	1	-I	-i	RBS
cord-265900-7lj4bfli	193	2	-	-	HYPH
cord-265900-7lj4bfli	193	3	mediated	mediate	VBN
cord-265900-7lj4bfli	193	4	signaling	signaling	NN
cord-265900-7lj4bfli	193	5	by	by	IN
cord-265900-7lj4bfli	193	6	Kaposi	Kaposi	NNP
cord-265900-7lj4bfli	193	7	's	's	POS
cord-265900-7lj4bfli	193	8	sarcoma	sarcoma	NN
cord-265900-7lj4bfli	193	9	-	-	HYPH
cord-265900-7lj4bfli	193	10	associated	associate	VBN
cord-265900-7lj4bfli	193	11	herpesvirus	herpesvirus	NN
cord-265900-7lj4bfli	193	12	-	-	HYPH
cord-265900-7lj4bfli	193	13	encoded	encode	VBN
cord-265900-7lj4bfli	193	14	deubiquitinase	deubiquitinase	NN
cord-265900-7lj4bfli	193	15	ORF64	ORF64	VBD
cord-265900-7lj4bfli	193	16	Positive	positive	JJ
cord-265900-7lj4bfli	193	17	regulation	regulation	NN
cord-265900-7lj4bfli	193	18	of	of	IN
cord-265900-7lj4bfli	193	19	interferon	interferon	NN
cord-265900-7lj4bfli	193	20	regulatory	regulatory	JJ
cord-265900-7lj4bfli	193	21	factor	factor	NN
cord-265900-7lj4bfli	193	22	3	3	CD
cord-265900-7lj4bfli	193	23	activation	activation	NN
cord-265900-7lj4bfli	193	24	by	by	IN
cord-265900-7lj4bfli	193	25	Herc5	Herc5	NNP
cord-265900-7lj4bfli	194	1	via	via	IN
cord-265900-7lj4bfli	194	2	ISG15	ISG15	NNP
cord-265900-7lj4bfli	194	3	modification	modification	NN
cord-265900-7lj4bfli	195	1	Negative	negative	JJ
cord-265900-7lj4bfli	195	2	feedback	feedback	NN
cord-265900-7lj4bfli	195	3	regulation	regulation	NN
cord-265900-7lj4bfli	195	4	of	of	IN
cord-265900-7lj4bfli	195	5	RIG	rig	NN
cord-265900-7lj4bfli	195	6	-	-	HYPH
cord-265900-7lj4bfli	195	7	I	i	NN
cord-265900-7lj4bfli	195	8	-	-	HYPH
cord-265900-7lj4bfli	195	9	mediated	mediate	VBN
cord-265900-7lj4bfli	195	10	antiviral	antiviral	JJ
cord-265900-7lj4bfli	195	11	signaling	signaling	NN
cord-265900-7lj4bfli	195	12	by	by	IN
cord-265900-7lj4bfli	195	13	interferoninduced	interferoninduce	VBN
cord-265900-7lj4bfli	195	14	ISG15	ISG15	NNP
cord-265900-7lj4bfli	195	15	conjugation	conjugation	NN
cord-265900-7lj4bfli	195	16	Human	Human	NNP
cord-265900-7lj4bfli	195	17	ISG15	ISG15	NNP
cord-265900-7lj4bfli	195	18	conjugation	conjugation	NN
cord-265900-7lj4bfli	195	19	targets	target	NNS
cord-265900-7lj4bfli	195	20	both	both	CC
cord-265900-7lj4bfli	195	21	IFN	IFN	NNP
cord-265900-7lj4bfli	195	22	-	-	HYPH
cord-265900-7lj4bfli	195	23	induced	induce	VBN
cord-265900-7lj4bfli	195	24	and	and	CC
cord-265900-7lj4bfli	195	25	constitutively	constitutively	RB
cord-265900-7lj4bfli	195	26	expressed	express	VBD
cord-265900-7lj4bfli	195	27	proteins	protein	NNS
cord-265900-7lj4bfli	195	28	functioning	function	VBG
cord-265900-7lj4bfli	195	29	in	in	IN
cord-265900-7lj4bfli	195	30	diverse	diverse	JJ
cord-265900-7lj4bfli	195	31	cellular	cellular	JJ
cord-265900-7lj4bfli	195	32	pathways	pathway	NNS
cord-265900-7lj4bfli	196	1	Influenza	Influenza	NNP
cord-265900-7lj4bfli	196	2	B	B	NNP
cord-265900-7lj4bfli	196	3	virus	virus	NN
cord-265900-7lj4bfli	196	4	NS1	ns1	NN
cord-265900-7lj4bfli	196	5	protein	protein	NN
cord-265900-7lj4bfli	196	6	inhibits	inhibit	VBZ
cord-265900-7lj4bfli	196	7	conjugation	conjugation	NN
cord-265900-7lj4bfli	196	8	of	of	IN
cord-265900-7lj4bfli	196	9	the	the	DT
cord-265900-7lj4bfli	196	10	interferon	interferon	NN
cord-265900-7lj4bfli	196	11	(	(	-LRB-
cord-265900-7lj4bfli	196	12	IFN)-induced	ifn)-induce	VBN
cord-265900-7lj4bfli	196	13	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	196	14	-	-	HYPH
cord-265900-7lj4bfli	196	15	like	like	JJ
cord-265900-7lj4bfli	196	16	ISG15	ISG15	NNP
cord-265900-7lj4bfli	196	17	protein	protein	NN
cord-265900-7lj4bfli	196	18	Vaccinia	Vaccinia	NNP
cord-265900-7lj4bfli	196	19	virus	virus	NN
cord-265900-7lj4bfli	196	20	E3	e3	NN
cord-265900-7lj4bfli	196	21	protein	protein	NN
cord-265900-7lj4bfli	196	22	prevents	prevent	VBZ
cord-265900-7lj4bfli	196	23	the	the	DT
cord-265900-7lj4bfli	196	24	antiviral	antiviral	JJ
cord-265900-7lj4bfli	196	25	action	action	NN
cord-265900-7lj4bfli	196	26	of	of	IN
cord-265900-7lj4bfli	196	27	ISG15	ISG15	NNP
cord-265900-7lj4bfli	196	28	Structural	Structural	NNP
cord-265900-7lj4bfli	196	29	Basis	Basis	NNP
cord-265900-7lj4bfli	196	30	for	for	IN
cord-265900-7lj4bfli	196	31	the	the	DT
cord-265900-7lj4bfli	196	32	Ubiquitin	Ubiquitin	NNP
cord-265900-7lj4bfli	196	33	-	-	HYPH
cord-265900-7lj4bfli	196	34	Linkage	linkage	NN
cord-265900-7lj4bfli	196	35	Specificity	Specificity	NNP
cord-265900-7lj4bfli	196	36	and	and	CC
cord-265900-7lj4bfli	196	37	deISGylating	deisgylate	VBG
cord-265900-7lj4bfli	196	38	activity	activity	NN
cord-265900-7lj4bfli	196	39	of	of	IN
cord-265900-7lj4bfli	196	40	SARS	SARS	NNP
cord-265900-7lj4bfli	196	41	-	-	HYPH
cord-265900-7lj4bfli	196	42	CoV	CoV	NNP
cord-265900-7lj4bfli	196	43	papain	papain	NN
cord-265900-7lj4bfli	196	44	-	-	HYPH
cord-265900-7lj4bfli	196	45	like	like	JJ
cord-265900-7lj4bfli	196	46	protease	protease	NN
cord-265900-7lj4bfli	197	1	This	this	DT
cord-265900-7lj4bfli	197	2	study	study	NN
cord-265900-7lj4bfli	197	3	identified	identify	VBD
cord-265900-7lj4bfli	197	4	the	the	DT
cord-265900-7lj4bfli	197	5	key	key	JJ
cord-265900-7lj4bfli	197	6	sites	site	NNS
cord-265900-7lj4bfli	197	7	required	require	VBN
cord-265900-7lj4bfli	197	8	for	for	IN
cord-265900-7lj4bfli	197	9	the	the	DT
cord-265900-7lj4bfli	197	10	deubiquitinating	deubiquitinating	NN
cord-265900-7lj4bfli	197	11	and	and	CC
cord-265900-7lj4bfli	197	12	deISGylating	deisgylate	VBG
cord-265900-7lj4bfli	197	13	activities	activity	NNS
cord-265900-7lj4bfli	197	14	of	of	IN
cord-265900-7lj4bfli	197	15	the	the	DT
cord-265900-7lj4bfli	197	16	papain	papain	NN
cord-265900-7lj4bfli	197	17	-	-	HYPH
cord-265900-7lj4bfli	197	18	like	like	JJ
cord-265900-7lj4bfli	197	19	protease	protease	NN
cord-265900-7lj4bfli	197	20	of	of	IN
cord-265900-7lj4bfli	197	21	SARS	SARS	NNP
cord-265900-7lj4bfli	197	22	-	-	HYPH
cord-265900-7lj4bfli	197	23	CoV	CoV	NNP
cord-265900-7lj4bfli	197	24	Ovarian	ovarian	JJ
cord-265900-7lj4bfli	197	25	tumor	tumor	NN
cord-265900-7lj4bfli	197	26	domain	domain	NN
cord-265900-7lj4bfli	197	27	-	-	HYPH
cord-265900-7lj4bfli	197	28	containing	contain	VBG
cord-265900-7lj4bfli	197	29	viral	viral	JJ
cord-265900-7lj4bfli	197	30	proteases	protease	NNS
cord-265900-7lj4bfli	197	31	evade	evade	VBP
cord-265900-7lj4bfli	197	32	ubiquitin	ubiquitin	NN
cord-265900-7lj4bfli	197	33	-	-	:
cord-265900-7lj4bfli	197	34	and	and	CC
cord-265900-7lj4bfli	197	35	ISG15-dependent	isg15-dependent	CD
cord-265900-7lj4bfli	197	36	innate	innate	JJ
cord-265900-7lj4bfli	197	37	immune	immune	JJ
cord-265900-7lj4bfli	197	38	responses	response	NNS
cord-265900-7lj4bfli	198	1	Arterivirus	Arterivirus	NNP
cord-265900-7lj4bfli	198	2	and	and	CC
cord-265900-7lj4bfli	198	3	nairovirus	nairovirus	NNP
cord-265900-7lj4bfli	198	4	ovarian	ovarian	JJ
cord-265900-7lj4bfli	198	5	tumor	tumor	NN
cord-265900-7lj4bfli	198	6	domain	domain	NN
cord-265900-7lj4bfli	198	7	-	-	:
cord-265900-7lj4bfli	198	8	containing	contain	VBG
cord-265900-7lj4bfli	198	9	Deubiquitinases	Deubiquitinases	NNP
cord-265900-7lj4bfli	198	10	target	target	NN
cord-265900-7lj4bfli	198	11	activated	activate	VBN
cord-265900-7lj4bfli	198	12	RIG	rig	NN
cord-265900-7lj4bfli	198	13	-	-	:
cord-265900-7lj4bfli	198	14	I	i	NN
cord-265900-7lj4bfli	198	15	to	to	TO
cord-265900-7lj4bfli	198	16	control	control	VB
cord-265900-7lj4bfli	198	17	innate	innate	JJ
cord-265900-7lj4bfli	198	18	immune	immune	NN
cord-265900-7lj4bfli	198	19	signaling	signal	VBG
cord-265900-7lj4bfli	198	20	This	this	DT
cord-265900-7lj4bfli	198	21	work	work	NN
cord-265900-7lj4bfli	198	22	was	be	VBD
cord-265900-7lj4bfli	198	23	supported	support	VBN
cord-265900-7lj4bfli	198	24	by	by	IN
cord-265900-7lj4bfli	198	25	the	the	DT
cord-265900-7lj4bfli	198	26	Canadian	Canadian	NNP
cord-265900-7lj4bfli	198	27	Institutes	Institutes	NNPS
cord-265900-7lj4bfli	198	28	of	of	IN
cord-265900-7lj4bfli	198	29	Health	Health	NNP
cord-265900-7lj4bfli	198	30	Research	Research	NNP
cord-265900-7lj4bfli	198	31	(	(	-LRB-
cord-265900-7lj4bfli	198	32	CIHR	CIHR	NNP
cord-265900-7lj4bfli	198	33	,	,	,
cord-265900-7lj4bfli	198	34	MOP-119274	MOP-119274	NNP
cord-265900-7lj4bfli	198	35	,	,	,
cord-265900-7lj4bfli	198	36	and	and	CC
cord-265900-7lj4bfli	198	37	CCI-125685	CCI-125685	NNP
cord-265900-7lj4bfli	198	38	)	)	-RRB-
cord-265900-7lj4bfli	198	39	.	.	.