id sid tid token lemma pos cord-020235-stcrozdw 1 1 key key NNP cord-020235-stcrozdw 1 2 : : : cord-020235-stcrozdw 1 3 cord-020235-stcrozdw cord-020235-stcrozdw . cord-020235-stcrozdw 2 1 authors author NNS cord-020235-stcrozdw 2 2 : : : cord-020235-stcrozdw 3 1 nan nan NNP cord-020235-stcrozdw 3 2 title title NN cord-020235-stcrozdw 3 3 : : : cord-020235-stcrozdw 3 4 Abstracts abstract NNS cord-020235-stcrozdw 3 5 of of IN cord-020235-stcrozdw 3 6 Papers Papers NNPS cord-020235-stcrozdw 3 7 Presented present VBN cord-020235-stcrozdw 3 8 at at IN cord-020235-stcrozdw 3 9 the the DT cord-020235-stcrozdw 3 10 38th 38th JJ cord-020235-stcrozdw 3 11 Meeting Meeting NNP cord-020235-stcrozdw 3 12 of of IN cord-020235-stcrozdw 3 13 the the DT cord-020235-stcrozdw 3 14 Deutsche Deutsche NNP cord-020235-stcrozdw 3 15 Gesellschaft Gesellschaft NNP cord-020235-stcrozdw 3 16 für für IN cord-020235-stcrozdw 3 17 Hygiene Hygiene NNP cord-020235-stcrozdw 3 18 und und IN cord-020235-stcrozdw 3 19 Mikrobiologie Mikrobiologie NNP cord-020235-stcrozdw 3 20 , , , cord-020235-stcrozdw 3 21 Virology Virology NNP cord-020235-stcrozdw 3 22 Section Section NNP cord-020235-stcrozdw 3 23 , , , cord-020235-stcrozdw 3 24 Göttingen Göttingen NNP cord-020235-stcrozdw 3 25 , , , cord-020235-stcrozdw 3 26 5.–8.10.1981 5.–8.10.1981 CD cord-020235-stcrozdw 3 27 date date NN cord-020235-stcrozdw 3 28 : : : cord-020235-stcrozdw 3 29 2012 2012 CD cord-020235-stcrozdw 3 30 - - HYPH cord-020235-stcrozdw 3 31 03 03 CD cord-020235-stcrozdw 3 32 - - SYM cord-020235-stcrozdw 3 33 15 15 CD cord-020235-stcrozdw 3 34 journal journal NN cord-020235-stcrozdw 3 35 : : : cord-020235-stcrozdw 4 1 Zentralbl Zentralbl NNP cord-020235-stcrozdw 4 2 Bakteriol Bakteriol NNP cord-020235-stcrozdw 5 1 Mikrobiol Mikrobiol NNP cord-020235-stcrozdw 5 2 Hyg Hyg NNP cord-020235-stcrozdw 6 1 A a DT cord-020235-stcrozdw 6 2 DOI doi NN cord-020235-stcrozdw 6 3 : : : cord-020235-stcrozdw 6 4 10.1016 10.1016 CD cord-020235-stcrozdw 6 5 / / SYM cord-020235-stcrozdw 6 6 s0174 s0174 NNP cord-020235-stcrozdw 6 7 - - HYPH cord-020235-stcrozdw 6 8 3031(82)80128 3031(82)80128 NNP cord-020235-stcrozdw 6 9 - - HYPH cord-020235-stcrozdw 6 10 5 5 CD cord-020235-stcrozdw 6 11 sha sha NNP cord-020235-stcrozdw 6 12 : : : cord-020235-stcrozdw 7 1 3839333dfd958691ee5c18a3c0baaedd9658bfc3 3839333dfd958691ee5c18a3c0baaedd9658bfc3 CD cord-020235-stcrozdw 7 2 doc_id doc_id CD cord-020235-stcrozdw 7 3 : : : cord-020235-stcrozdw 7 4 20235 20235 CD cord-020235-stcrozdw 7 5 cord_uid cord_uid NNS cord-020235-stcrozdw 7 6 : : : cord-020235-stcrozdw 8 1 stcrozdw stcrozdw NNP cord-020235-stcrozdw 8 2 nan nan NNP cord-020235-stcrozdw 8 3 SCHAEFER SCHAEFER NNP cord-020235-stcrozdw 8 4 , , , cord-020235-stcrozdw 8 5 A. A. NNP cord-020235-stcrozdw 8 6 , , , cord-020235-stcrozdw 8 7 ZIBIRRE ZIBIRRE NNP cord-020235-stcrozdw 8 8 , , , cord-020235-stcrozdw 8 9 R. R. NNP cord-020235-stcrozdw 8 10 , , , cord-020235-stcrozdw 8 11 KABUS KABUS NNP cord-020235-stcrozdw 8 12 , , , cord-020235-stcrozdw 8 13 P. P. NNP cord-020235-stcrozdw 8 14 , , , cord-020235-stcrozdw 8 15 KOHNE KOHNE NNP cord-020235-stcrozdw 8 16 , , , cord-020235-stcrozdw 8 17 JUTTA JUTTA NNP cord-020235-stcrozdw 8 18 , , , cord-020235-stcrozdw 8 19 and and CC cord-020235-stcrozdw 8 20 KOCH KOCH NNP cord-020235-stcrozdw 8 21 . . . cord-020235-stcrozdw 9 1 G. G. NNP cord-020235-stcrozdw 9 2 Na Na NNP cord-020235-stcrozdw 10 1 + + UH cord-020235-stcrozdw 10 2 , , , cord-020235-stcrozdw 10 3 K k NN cord-020235-stcrozdw 10 4 + + CC cord-020235-stcrozdw 11 1 -ATPase -ATPase NNP cord-020235-stcrozdw 12 1 activity activity NN cord-020235-stcrozdw 12 2 was be VBD cord-020235-stcrozdw 12 3 studied study VBN cord-020235-stcrozdw 12 4 in in IN cord-020235-stcrozdw 12 5 a a DT cord-020235-stcrozdw 12 6 plasma plasma NN cord-020235-stcrozdw 12 7 membrane membrane NN cord-020235-stcrozdw 12 8 rich rich JJ cord-020235-stcrozdw 12 9 fraction fraction NN cord-020235-stcrozdw 12 10 isolated isolate VBN cord-020235-stcrozdw 12 11 from from IN cord-020235-stcrozdw 12 12 control control NN cord-020235-stcrozdw 12 13 and and CC cord-020235-stcrozdw 12 14 poliovirus poliovirus NN cord-020235-stcrozdw 12 15 infected infect VBN cord-020235-stcrozdw 12 16 He -PRON- PRP cord-020235-stcrozdw 12 17 La La NNP cord-020235-stcrozdw 12 18 cells cell NNS cord-020235-stcrozdw 12 19 and and CC cord-020235-stcrozdw 12 20 compared compare VBN cord-020235-stcrozdw 12 21 to to IN cord-020235-stcrozdw 12 22 membrane membrane NN cord-020235-stcrozdw 12 23 potential potential JJ cord-020235-stcrozdw 12 24 and and CC cord-020235-stcrozdw 12 25 amino amino NN cord-020235-stcrozdw 12 26 acid acid NN cord-020235-stcrozdw 12 27 uptake uptake NN cord-020235-stcrozdw 12 28 in in IN cord-020235-stcrozdw 12 29 parallel parallel JJ cord-020235-stcrozdw 12 30 cultures culture NNS cord-020235-stcrozdw 12 31 of of IN cord-020235-stcrozdw 12 32 intact intact JJ cord-020235-stcrozdw 12 33 cells cell NNS cord-020235-stcrozdw 12 34 . . . cord-020235-stcrozdw 13 1 Na Na NNP cord-020235-stcrozdw 13 2 + + CC cord-020235-stcrozdw 13 3 , , , cord-020235-stcrozdw 13 4 K K NNP cord-020235-stcrozdw 13 5 + + CC cord-020235-stcrozdw 13 6 -AT -AT . cord-020235-stcrozdw 14 1 Pase pase JJ cord-020235-stcrozdw 14 2 activity activity NN cord-020235-stcrozdw 14 3 in in IN cord-020235-stcrozdw 14 4 membranes membrane NNS cord-020235-stcrozdw 14 5 from from IN cord-020235-stcrozdw 14 6 infected infected JJ cord-020235-stcrozdw 14 7 HeLa HeLa NNP cord-020235-stcrozdw 14 8 cells cell NNS cord-020235-stcrozdw 14 9 increased increase VBD cord-020235-stcrozdw 14 10 relative relative JJ cord-020235-stcrozdw 14 11 to to IN cord-020235-stcrozdw 14 12 control control VB cord-020235-stcrozdw 14 13 with with IN cord-020235-stcrozdw 14 14 a a DT cord-020235-stcrozdw 14 15 maximum maximum NN cord-020235-stcrozdw 14 16 at at IN cord-020235-stcrozdw 14 17 90 90 CD cord-020235-stcrozdw 14 18 minutes minute NNS cord-020235-stcrozdw 14 19 post post NN cord-020235-stcrozdw 14 20 infection infection NN cord-020235-stcrozdw 14 21 ( ( -LRB- cord-020235-stcrozdw 14 22 + + SYM cord-020235-stcrozdw 14 23 30 30 CD cord-020235-stcrozdw 14 24 % % NN cord-020235-stcrozdw 14 25 ) ) -RRB- cord-020235-stcrozdw 14 26 and and CC cord-020235-stcrozdw 14 27 decreased decrease VBD cord-020235-stcrozdw 14 28 again again RB cord-020235-stcrozdw 14 29 ( ( -LRB- cord-020235-stcrozdw 14 30 180 180 CD cord-020235-stcrozdw 14 31 rnin rnin NN cord-020235-stcrozdw 14 32 . . . cord-020235-stcrozdw 15 1 : : : cord-020235-stcrozdw 15 2 -30 -30 CD cord-020235-stcrozdw 15 3 % % NN cord-020235-stcrozdw 15 4 ) ) -RRB- cord-020235-stcrozdw 15 5 . . . cord-020235-stcrozdw 16 1 Similar similar JJ cord-020235-stcrozdw 16 2 but but CC cord-020235-stcrozdw 16 3 slighter slight JJR cord-020235-stcrozdw 16 4 changes change NNS cord-020235-stcrozdw 16 5 were be VBD cord-020235-stcrozdw 16 6 observed observe VBN cord-020235-stcrozdw 16 7 in in IN cord-020235-stcrozdw 16 8 the the DT cord-020235-stcrozdw 16 9 membrane membrane NN cord-020235-stcrozdw 16 10 potential potential JJ cord-020235-stcrozdw 16 11 dependent dependent JJ cord-020235-stcrozdw 16 12 tetraphenylphosphonium tetraphenylphosphonium NN cord-020235-stcrozdw 16 13 ( ( -LRB- cord-020235-stcrozdw 16 14 T T NNP cord-020235-stcrozdw 16 15 PP+ PP+ NNP cord-020235-stcrozdw 16 16 ) ) -RRB- cord-020235-stcrozdw 16 17 uptake uptake NN cord-020235-stcrozdw 16 18 , , , cord-020235-stcrozdw 16 19 indicating indicate VBG cord-020235-stcrozdw 16 20 a a DT cord-020235-stcrozdw 16 21 correlation correlation NN cord-020235-stcrozdw 16 22 between between IN cord-020235-stcrozdw 16 23 membrane membrane NN cord-020235-stcrozdw 16 24 porential porential NN cord-020235-stcrozdw 16 25 in in IN cord-020235-stcrozdw 16 26 intact intact JJ cord-020235-stcrozdw 16 27 cells cell NNS cord-020235-stcrozdw 16 28 and and CC cord-020235-stcrozdw 16 29 our -PRON- PRP$ cord-020235-stcrozdw 16 30 measurment measurment NN cord-020235-stcrozdw 16 31 of of IN cord-020235-stcrozdw 16 32 plasma plasma NN cord-020235-stcrozdw 16 33 membrane membrane NN cord-020235-stcrozdw 16 34 Na Na NNP cord-020235-stcrozdw 16 35 + + CC cord-020235-stcrozdw 16 36 , , , cord-020235-stcrozdw 16 37 K K NNP cord-020235-stcrozdw 16 38 + + CC cord-020235-stcrozdw 16 39 -AT -AT . cord-020235-stcrozdw 17 1 Pase Pase NNP cord-020235-stcrozdw 17 2 . . . cord-020235-stcrozdw 18 1 At at IN cord-020235-stcrozdw 18 2 approximately approximately RB cord-020235-stcrozdw 18 3 1 1 CD cord-020235-stcrozdw 18 4 h h NN cord-020235-stcrozdw 18 5 post post NN cord-020235-stcrozdw 18 6 infection infection NN cord-020235-stcrozdw 18 7 we -PRON- PRP cord-020235-stcrozdw 18 8 observed observe VBD cord-020235-stcrozdw 18 9 a a DT cord-020235-stcrozdw 18 10 decrease decrease NN cord-020235-stcrozdw 18 11 in in IN cord-020235-stcrozdw 18 12 the the DT cord-020235-stcrozdw 18 13 uptake uptake NN cord-020235-stcrozdw 18 14 of of IN cord-020235-stcrozdw 18 15 amino amino NN cord-020235-stcrozdw 18 16 acid acid NN cord-020235-stcrozdw 18 17 ( ( -LRB- cord-020235-stcrozdw 18 18 methionine methionine NN cord-020235-stcrozdw 18 19 , , , cord-020235-stcrozdw 18 20 leucine leucine NN cord-020235-stcrozdw 18 21 ) ) -RRB- cord-020235-stcrozdw 18 22 in in IN cord-020235-stcrozdw 18 23 infected infected JJ cord-020235-stcrozdw 18 24 cells cell NNS cord-020235-stcrozdw 18 25 relative relative JJ cord-020235-stcrozdw 18 26 to to IN cord-020235-stcrozdw 18 27 controls control NNS cord-020235-stcrozdw 18 28 . . . cord-020235-stcrozdw 19 1 These these DT cord-020235-stcrozdw 19 2 results result NNS cord-020235-stcrozdw 19 3 suggest suggest VBP cord-020235-stcrozdw 19 4 that that IN cord-020235-stcrozdw 19 5 the the DT cord-020235-stcrozdw 19 6 decline decline NN cord-020235-stcrozdw 19 7 in in IN cord-020235-stcrozdw 19 8 amino amino NN cord-020235-stcrozdw 19 9 acid acid NN cord-020235-stcrozdw 19 10 upt upt NNP cord-020235-stcrozdw 19 11 ake ake NNP cord-020235-stcrozdw 19 12 is be VBZ cord-020235-stcrozdw 19 13 not not RB cord-020235-stcrozdw 19 14 mediated mediate VBN cord-020235-stcrozdw 19 15 by by IN cord-020235-stcrozdw 19 16 virus virus NN cord-020235-stcrozdw 19 17 - - HYPH cord-020235-stcrozdw 19 18 induced induce VBN cord-020235-stcrozdw 19 19 changes change NNS cord-020235-stcrozdw 19 20 in in IN cord-020235-stcrozdw 19 21 the the DT cord-020235-stcrozdw 19 22 Na Na NNP cord-020235-stcrozdw 19 23 + + CC cord-020235-stcrozdw 19 24 , , , cord-020235-stcrozdw 19 25 K k NN cord-020235-stcrozdw 19 26 + + CC cord-020235-stcrozdw 19 27 -ATPase -atpase NN cord-020235-stcrozdw 19 28 activity activity NN cord-020235-stcrozdw 19 29 or or CC cord-020235-stcrozdw 19 30 membrane membrane NN cord-020235-stcrozdw 19 31 potential potential NN cord-020235-stcrozdw 19 32 . . . cord-020235-stcrozdw 20 1 MPI MPI NNP cord-020235-stcrozdw 20 2 f. f. NN cord-020235-stcrozdw 20 3 Biochemic Biochemic NNP cord-020235-stcrozdw 20 4 , , , cord-020235-stcrozdw 20 5 Abt Abt NNP cord-020235-stcrozdw 20 6 . . . cord-020235-stcrozdw 21 1 Virologic Virologic NNP cord-020235-stcrozdw 21 2 , , , cord-020235-stcrozdw 21 3 Sequence sequence NN cord-020235-stcrozdw 21 4 Homology homology NN cord-020235-stcrozdw 21 5 in in IN cord-020235-stcrozdw 21 6 Different different JJ cord-020235-stcrozdw 21 7 Strains strain NNS cord-020235-stcrozdw 21 8 of of IN cord-020235-stcrozdw 21 9 FMDV FMDV NNP cord-020235-stcrozdw 21 10 and and CC cord-020235-stcrozdw 21 11 other other JJ cord-020235-stcrozdw 21 12 Picoma Picoma NNP cord-020235-stcrozdw 21 13 Viruses Viruses NNPS cord-020235-stcrozdw 21 14 MARQUARDT MARQUARDT NNP cord-020235-stcrozdw 21 15 , , , cord-020235-stcrozdw 22 1 O. O. NNP cord-020235-stcrozdw 22 2 Restriction Restriction NNP cord-020235-stcrozdw 22 3 enzyme enzyme NN cord-020235-stcrozdw 22 4 generated generate VBD cord-020235-stcrozdw 22 5 subgenomic subgenomic JJ cord-020235-stcrozdw 22 6 fragments fragment NNS cord-020235-stcrozdw 22 7 of of IN cord-020235-stcrozdw 22 8 cloned clone VBN cord-020235-stcrozdw 22 9 cDNA cdna NN cord-020235-stcrozdw 22 10 prepared prepare VBN cord-020235-stcrozdw 22 11 from from IN cord-020235-stcrozdw 22 12 RNA RNA NNP cord-020235-stcrozdw 22 13 of of IN cord-020235-stcrozdw 22 14 the the DT cord-020235-stcrozdw 22 15 strain strain NN cord-020235-stcrozdw 22 16 01 01 CD cord-020235-stcrozdw 22 17 K K NNP cord-020235-stcrozdw 22 18 of of IN cord-020235-stcrozdw 22 19 FMDV FMDV NNP cord-020235-stcrozdw 22 20 were be VBD cord-020235-stcrozdw 22 21 compared compare VBN cord-020235-stcrozdw 22 22 quantitatively quantitatively RB cord-020235-stcrozdw 22 23 for for IN cord-020235-stcrozdw 22 24 sequence sequence NN cord-020235-stcrozdw 22 25 complementarity complementarity NN cord-020235-stcrozdw 22 26 with with IN cord-020235-stcrozdw 22 27 radioactive radioactive JJ cord-020235-stcrozdw 22 28 RNA RNA NNP cord-020235-stcrozdw 22 29 from from IN cord-020235-stcrozdw 22 30 strains strain NNS cord-020235-stcrozdw 22 31 CObb cobb NN cord-020235-stcrozdw 22 32 and and CC cord-020235-stcrozdw 22 33 A2S a2s NN cord-020235-stcrozdw 22 34 or or CC cord-020235-stcrozdw 22 35 with with IN cord-020235-stcrozdw 22 36 RNA RNA NNP cord-020235-stcrozdw 22 37 from from IN cord-020235-stcrozdw 22 38 mengo mengo NNS cord-020235-stcrozdw 22 39 or or CC cord-020235-stcrozdw 22 40 polio polio NN cord-020235-stcrozdw 22 41 virus virus NN cord-020235-stcrozdw 22 42 in in IN cord-020235-stcrozdw 22 43 hybridization hybridization NN cord-020235-stcrozdw 22 44 experiments experiment NNS cord-020235-stcrozdw 22 45 by by IN cord-020235-stcrozdw 22 46 use use NN cord-020235-stcrozdw 22 47 of of IN cord-020235-stcrozdw 22 48 the the DT cord-020235-stcrozdw 22 49 Southern southern JJ cord-020235-stcrozdw 22 50 technique technique NN cord-020235-stcrozdw 22 51 . . . cord-020235-stcrozdw 23 1 Nucleic nucleic JJ cord-020235-stcrozdw 23 2 acid acid NN cord-020235-stcrozdw 23 3 sequences sequence NNS cord-020235-stcrozdw 23 4 neighbouring neighbour VBG cord-020235-stcrozdw 23 5 or or CC cord-020235-stcrozdw 23 6 including include VBG cord-020235-stcrozdw 23 7 the the DT cord-020235-stcrozdw 23 8 3 3 CD cord-020235-stcrozdw 23 9 ' ' NN cord-020235-stcrozdw 23 10 end end NN cord-020235-stcrozdw 23 11 of of IN cord-020235-stcrozdw 23 12 viral viral JJ cord-020235-stcrozdw 23 13 genomes genome NNS cord-020235-stcrozdw 23 14 are be VBP cord-020235-stcrozdw 23 15 demonstrated demonstrate VBN cord-020235-stcrozdw 23 16 to to TO cord-020235-stcrozdw 23 17 be be VB cord-020235-stcrozdw 23 18 80 80 CD cord-020235-stcrozdw 23 19 Ofo Ofo NNP cord-020235-stcrozdw 23 20 homologous homologous JJ cord-020235-stcrozdw 23 21 in in IN cord-020235-stcrozdw 23 22 FMDV FMDV NNP cord-020235-stcrozdw 23 23 . . . cord-020235-stcrozdw 24 1 In in IN cord-020235-stcrozdw 24 2 contrast contrast NN cord-020235-stcrozdw 24 3 , , , cord-020235-stcrozdw 24 4 sequences sequence NNS cord-020235-stcrozdw 24 5 coding code VBG cord-020235-stcrozdw 24 6 for for IN cord-020235-stcrozdw 24 7 the the DT cord-020235-stcrozdw 24 8 capsid capsid NN cord-020235-stcrozdw 24 9 proteins protein NNS cord-020235-stcrozdw 24 10 VPl VPl NNS cord-020235-stcrozdw 24 11 and and CC cord-020235-stcrozdw 24 12 VP3 VP3 NNP cord-020235-stcrozdw 24 13 were be VBD cord-020235-stcrozdw 24 14 remarkably remarkably RB cord-020235-stcrozdw 24 15 heterologous heterologous JJ cord-020235-stcrozdw 24 16 ( ( -LRB- cord-020235-stcrozdw 24 17 less less JJR cord-020235-stcrozdw 24 18 than than IN cord-020235-stcrozdw 24 19 20010 20010 CD cord-020235-stcrozdw 24 20 ) ) -RRB- cord-020235-stcrozdw 24 21 in in IN cord-020235-stcrozdw 24 22 FMDV FMDV NNP cord-020235-stcrozdw 24 23 . . . cord-020235-stcrozdw 25 1 Sequences sequence NNS cord-020235-stcrozdw 25 2 coding code VBG cord-020235-stcrozdw 25 3 for for IN cord-020235-stcrozdw 25 4 non non JJ cord-020235-stcrozdw 25 5 - - JJ cord-020235-stcrozdw 25 6 structural structural JJ cord-020235-stcrozdw 25 7 proteins protein NNS cord-020235-stcrozdw 25 8 showed show VBD cord-020235-stcrozdw 25 9 35 35 CD cord-020235-stcrozdw 25 10 - - SYM cord-020235-stcrozdw 25 11 50010 50010 CD cord-020235-stcrozdw 25 12 homology homology NN cord-020235-stcrozdw 25 13 . . . cord-020235-stcrozdw 26 1 Thus thus RB cord-020235-stcrozdw 26 2 no no DT cord-020235-stcrozdw 26 3 highly highly RB cord-020235-stcrozdw 26 4 conserved conserved JJ cord-020235-stcrozdw 26 5 coding coding NN cord-020235-stcrozdw 26 6 sequence sequence NN cord-020235-stcrozdw 26 7 was be VBD cord-020235-stcrozdw 26 8 detectable detectable JJ cord-020235-stcrozdw 26 9 in in IN cord-020235-stcrozdw 26 10 FMDV FMDV NNP cord-020235-stcrozdw 26 11 by by IN cord-020235-stcrozdw 26 12 this this DT cord-020235-stcrozdw 26 13 technique technique NN cord-020235-stcrozdw 26 14 . . . cord-020235-stcrozdw 27 1 No no DT cord-020235-stcrozdw 27 2 hybridization hybridization NN cord-020235-stcrozdw 27 3 could could MD cord-020235-stcrozdw 27 4 .be .be CD cord-020235-stcrozdw 27 5 detected detect VBN cord-020235-stcrozdw 27 6 between between IN cord-020235-stcrozdw 27 7 01 01 CD cord-020235-stcrozdw 27 8 K K NNP cord-020235-stcrozdw 27 9 specific specific JJ cord-020235-stcrozdw 27 10 DNA dna NN cord-020235-stcrozdw 27 11 and and CC cord-020235-stcrozdw 27 12 polio polio NN cord-020235-stcrozdw 27 13 RNA RNA NNP cord-020235-stcrozdw 27 14 , , , cord-020235-stcrozdw 27 15 while while IN cord-020235-stcrozdw 27 16 weak weak JJ cord-020235-stcrozdw 27 17 hybridization hybridization NN cord-020235-stcrozdw 27 18 was be VBD cord-020235-stcrozdw 27 19 observed observe VBN cord-020235-stcrozdw 27 20 with with IN cord-020235-stcrozdw 27 21 mengo mengo NNP cord-020235-stcrozdw 27 22 RNA RNA NNP cord-020235-stcrozdw 27 23 at at IN cord-020235-stcrozdw 27 24 areas area NNS cord-020235-stcrozdw 27 25 including include VBG cord-020235-stcrozdw 27 26 the the DT cord-020235-stcrozdw 27 27 3 3 CD cord-020235-stcrozdw 27 28 ' ' '' cord-020235-stcrozdw 27 29 end end NN cord-020235-stcrozdw 27 30 and and CC cord-020235-stcrozdw 27 31 with with IN cord-020235-stcrozdw 27 32 a a DT cord-020235-stcrozdw 27 33 part part NN cord-020235-stcrozdw 27 34 of of IN cord-020235-stcrozdw 27 35 the the DT cord-020235-stcrozdw 27 36 gene gene NN cord-020235-stcrozdw 27 37 for for IN cord-020235-stcrozdw 27 38 precursor precursor NN cord-020235-stcrozdw 27 39 protein protein NN cord-020235-stcrozdw 27 40 P52 P52 NNP cord-020235-stcrozdw 27 41 . . . cord-020235-stcrozdw 28 1 Abr Abr NNP cord-020235-stcrozdw 28 2 , , , cord-020235-stcrozdw 28 3 Molekularbiologie Molekularbiologie NNP cord-020235-stcrozdw 28 4 , , , cord-020235-stcrozdw 28 5 Physiol Physiol NNP cord-020235-stcrozdw 28 6 - - HYPH cord-020235-stcrozdw 28 7 Chern Chern NNP cord-020235-stcrozdw 28 8 . . . cord-020235-stcrozdw 29 1 Inst Inst NNP cord-020235-stcrozdw 29 2 . . . cord-020235-stcrozdw 30 1 , , , cord-020235-stcrozdw 30 2 Grindelallee Grindelallee NNP cord-020235-stcrozdw 30 3 117 117 CD cord-020235-stcrozdw 30 4 , , , cord-020235-stcrozdw 30 5 D-2000 d-2000 CD cord-020235-stcrozdw 31 1 Hamburg Hamburg NNP cord-020235-stcrozdw 31 2 13 13 CD cord-020235-stcrozdw 31 3 Modification Modification NNP cord-020235-stcrozdw 31 4 of of IN cord-020235-stcrozdw 31 5 Poliovirus Poliovirus NNP cord-020235-stcrozdw 31 6 Capsid Capsid NNP cord-020235-stcrozdw 31 7 Proteins Proteins NNP cord-020235-stcrozdw 31 8 SCHARLI SCHARLI NNP cord-020235-stcrozdw 31 9 , , , cord-020235-stcrozdw 31 10 CLAUDIA CLAUDIA NNP cord-020235-stcrozdw 31 11 and and CC cord-020235-stcrozdw 31 12 KOCH KOCH NNP cord-020235-stcrozdw 31 13 , , , cord-020235-stcrozdw 31 14 G. G. NNP cord-020235-stcrozdw 31 15 Poliovirus Poliovirus NNP cord-020235-stcrozdw 31 16 type type NN cord-020235-stcrozdw 31 17 1 1 CD cord-020235-stcrozdw 31 18 , , , cord-020235-stcrozdw 31 19 strain strain VB cord-020235-stcrozdw 31 20 Mohoney Mohoney NNP cord-020235-stcrozdw 31 21 contains contain VBZ cord-020235-stcrozdw 31 22 a a DT cord-020235-stcrozdw 31 23 protein protein NN cord-020235-stcrozdw 31 24 kinase kinase NN cord-020235-stcrozdw 31 25 activity activity NN cord-020235-stcrozdw 31 26 . . . cord-020235-stcrozdw 32 1 A a DT cord-020235-stcrozdw 32 2 highly highly RB cord-020235-stcrozdw 32 3 purified purify VBN cord-020235-stcrozdw 32 4 ( ( -LRB- cord-020235-stcrozdw 32 5 two two CD cord-020235-stcrozdw 32 6 cycles cycle NNS cord-020235-stcrozdw 32 7 of of IN cord-020235-stcrozdw 32 8 CsCI CsCI NNP cord-020235-stcrozdw 32 9 gradient gradient NN cord-020235-stcrozdw 32 10 centrifugation centrifugation NN cord-020235-stcrozdw 32 11 ) ) -RRB- cord-020235-stcrozdw 33 1 poliovirus poliovirus NN cord-020235-stcrozdw 33 2 preparation preparation NN cord-020235-stcrozdw 33 3 is be VBZ cord-020235-stcrozdw 33 4 able able JJ cord-020235-stcrozdw 33 5 to to TO cord-020235-stcrozdw 33 6 transfer transfer VB cord-020235-stcrozdw 33 7 the the DT cord-020235-stcrozdw 33 8 y y NNP cord-020235-stcrozdw 33 9 - - HYPH cord-020235-stcrozdw 33 10 phosphoryl phosphoryl NNP cord-020235-stcrozdw 33 11 - - HYPH cord-020235-stcrozdw 33 12 group group NN cord-020235-stcrozdw 33 13 of of IN cord-020235-stcrozdw 33 14 [ [ -LRB- cord-020235-stcrozdw 33 15 32P]_ATP 32P]_ATP NNS cord-020235-stcrozdw 33 16 to to TO cord-020235-stcrozdw 33 17 acid acid NN cord-020235-stcrozdw 33 18 precipitable precipitable JJ cord-020235-stcrozdw 33 19 material material NN cord-020235-stcrozdw 33 20 . . . cord-020235-stcrozdw 34 1 When when WRB cord-020235-stcrozdw 34 2 the the DT cord-020235-stcrozdw 34 3 reaction reaction NN cord-020235-stcrozdw 34 4 product product NN cord-020235-stcrozdw 34 5 is be VBZ cord-020235-stcrozdw 34 6 anal anal JJ cord-020235-stcrozdw 34 7 yzed yze VBN cord-020235-stcrozdw 34 8 by by IN cord-020235-stcrozdw 34 9 SDS SDS NNP cord-020235-stcrozdw 34 10 PAGE PAGE NNP cord-020235-stcrozdw 34 11 , , , cord-020235-stcrozdw 34 12 all all DT cord-020235-stcrozdw 34 13 structural structural JJ cord-020235-stcrozdw 34 14 proteins protein NNS cord-020235-stcrozdw 34 15 of of IN cord-020235-stcrozdw 34 16 polio polio NN cord-020235-stcrozdw 34 17 are be VBP cord-020235-stcrozdw 34 18 phoshorylated phoshorylate VBN cord-020235-stcrozdw 34 19 . . . cord-020235-stcrozdw 35 1 Most Most JJS cord-020235-stcrozdw 35 2 of of IN cord-020235-stcrozdw 35 3 the the DT cord-020235-stcrozdw 35 4 label label NN cord-020235-stcrozdw 35 5 is be VBZ cord-020235-stcrozdw 35 6 incorporated incorporate VBN cord-020235-stcrozdw 35 7 in in IN cord-020235-stcrozdw 35 8 the the DT cord-020235-stcrozdw 35 9 minor minor JJ cord-020235-stcrozdw 35 10 capsid capsid NN cord-020235-stcrozdw 35 11 protein protein NN cord-020235-stcrozdw 35 12 VPO VPO NNP cord-020235-stcrozdw 35 13 and and CC cord-020235-stcrozdw 35 14 to to IN cord-020235-stcrozdw 35 15 a a DT cord-020235-stcrozdw 35 16 lesser less JJR cord-020235-stcrozdw 35 17 extend extend NN cord-020235-stcrozdw 35 18 in in IN cord-020235-stcrozdw 35 19 VP1 vp1 NN cord-020235-stcrozdw 35 20 , , , cord-020235-stcrozdw 35 21 VP2 vp2 NN cord-020235-stcrozdw 35 22 and and CC cord-020235-stcrozdw 35 23 VP3 vp3 NN cord-020235-stcrozdw 35 24 . . . cord-020235-stcrozdw 36 1 Hepatitis Hepatitis NNP cord-020235-stcrozdw 36 2 A a DT cord-020235-stcrozdw 36 3 virus virus NN cord-020235-stcrozdw 36 4 ( ( -LRB- cord-020235-stcrozdw 36 5 HAV HAV NNP cord-020235-stcrozdw 36 6 ) ) -RRB- cord-020235-stcrozdw 36 7 was be VBD cord-020235-stcrozdw 36 8 isolated isolate VBN cord-020235-stcrozdw 36 9 directly directly RB cord-020235-stcrozdw 36 10 from from IN cord-020235-stcrozdw 36 11 human human JJ cord-020235-stcrozdw 36 12 stool stool NN cord-020235-stcrozdw 36 13 in in IN cord-020235-stcrozdw 36 14 diploid diploid JJ cord-020235-stcrozdw 36 15 human human JJ cord-020235-stcrozdw 36 16 fibroplasrs fibroplasrs NN cord-020235-stcrozdw 36 17 , , , cord-020235-stcrozdw 36 18 Viral viral JJ cord-020235-stcrozdw 36 19 antigen antigen NN cord-020235-stcrozdw 36 20 was be VBD cord-020235-stcrozdw 36 21 expressed express VBN cord-020235-stcrozdw 36 22 only only RB cord-020235-stcrozdw 36 23 after after IN cord-020235-stcrozdw 36 24 210 210 CD cord-020235-stcrozdw 36 25 days day NNS cord-020235-stcrozdw 36 26 of of IN cord-020235-stcrozdw 36 27 incubation incubation NN cord-020235-stcrozdw 36 28 of of IN cord-020235-stcrozdw 36 29 the the DT cord-020235-stcrozdw 36 30 infected infected JJ cord-020235-stcrozdw 36 31 cultures culture NNS cord-020235-stcrozdw 36 32 . . . cord-020235-stcrozdw 37 1 In in IN cord-020235-stcrozdw 37 2 contrast contrast NN cord-020235-stcrozdw 37 3 , , , cord-020235-stcrozdw 37 4 HAV HAV NNP cord-020235-stcrozdw 37 5 first first RB cord-020235-stcrozdw 37 6 adapted adapt VBN cord-020235-stcrozdw 37 7 to to IN cord-020235-stcrozdw 37 8 growth growth NN cord-020235-stcrozdw 37 9 in in IN cord-020235-stcrozdw 37 10 human human JJ cord-020235-stcrozdw 37 11 hepatocellular hepatocellular JJ cord-020235-stcrozdw 37 12 carcinoma carcinoma NN cord-020235-stcrozdw 37 13 cells cell NNS cord-020235-stcrozdw 37 14 caused cause VBD cord-020235-stcrozdw 37 15 antigen antigen NN cord-020235-stcrozdw 37 16 expression expression NN cord-020235-stcrozdw 37 17 in in IN cord-020235-stcrozdw 37 18 fibroplast fibroplast JJ cord-020235-stcrozdw 37 19 cultures culture NNS cord-020235-stcrozdw 37 20 already already RB cord-020235-stcrozdw 37 21 90 90 CD cord-020235-stcrozdw 37 22 days day NNS cord-020235-stcrozdw 37 23 after after IN cord-020235-stcrozdw 37 24 infection infection NN cord-020235-stcrozdw 37 25 . . . cord-020235-stcrozdw 38 1 During during IN cord-020235-stcrozdw 38 2 further further JJ cord-020235-stcrozdw 38 3 passage passage VB cord-020235-stcrozdw 38 4 the the DT cord-020235-stcrozdw 38 5 time time NN cord-020235-stcrozdw 38 6 of of IN cord-020235-stcrozdw 38 7 first first JJ cord-020235-stcrozdw 38 8 appearance appearance NN cord-020235-stcrozdw 38 9 of of IN cord-020235-stcrozdw 38 10 antigen antigen NN cord-020235-stcrozdw 38 11 in in IN cord-020235-stcrozdw 38 12 infected infected JJ cord-020235-stcrozdw 38 13 fibroblasts fibroblast NNS cord-020235-stcrozdw 38 14 decreased decrease VBD cord-020235-stcrozdw 38 15 to to IN cord-020235-stcrozdw 38 16 about about IN cord-020235-stcrozdw 38 17 14 14 CD cord-020235-stcrozdw 38 18 days day NNS cord-020235-stcrozdw 38 19 in in IN cord-020235-stcrozdw 38 20 both both DT cord-020235-stcrozdw 38 21 passage passage NN cord-020235-stcrozdw 38 22 series series NN cord-020235-stcrozdw 38 23 ( ( -LRB- cord-020235-stcrozdw 38 24 i. i. NNP cord-020235-stcrozdw 38 25 e. e. NNP cord-020235-stcrozdw 38 26 cultures culture NNS cord-020235-stcrozdw 38 27 inoculated inoculate VBN cord-020235-stcrozdw 38 28 with with IN cord-020235-stcrozdw 38 29 virus virus NN cord-020235-stcrozdw 38 30 recovered recover VBN cord-020235-stcrozdw 38 31 directly directly RB cord-020235-stcrozdw 38 32 from from IN cord-020235-stcrozdw 38 33 human human JJ cord-020235-stcrozdw 38 34 stool stool NN cord-020235-stcrozdw 38 35 or or CC cord-020235-stcrozdw 38 36 after after IN cord-020235-stcrozdw 38 37 adaption adaption NN cord-020235-stcrozdw 38 38 to to IN cord-020235-stcrozdw 38 39 human human JJ cord-020235-stcrozdw 38 40 hepatoma hepatoma NNP cord-020235-stcrozdw 38 41 cells cell NNS cord-020235-stcrozdw 38 42 ) ) -RRB- cord-020235-stcrozdw 38 43 . . . cord-020235-stcrozdw 39 1 Antigen Antigen NNP cord-020235-stcrozdw 39 2 was be VBD cord-020235-stcrozdw 39 3 predominantly predominantly RB cord-020235-stcrozdw 39 4 cell cell NN cord-020235-stcrozdw 39 5 - - HYPH cord-020235-stcrozdw 39 6 associated associate VBN cord-020235-stcrozdw 39 7 and and CC cord-020235-stcrozdw 39 8 was be VBD cord-020235-stcrozdw 39 9 shown show VBN cord-020235-stcrozdw 39 10 by by IN cord-020235-stcrozdw 39 11 immunofluorescence immunofluorescence NN cord-020235-stcrozdw 39 12 to to TO cord-020235-stcrozdw 39 13 be be VB cord-020235-stcrozdw 39 14 located locate VBN cord-020235-stcrozdw 39 15 exclusively exclusively RB cord-020235-stcrozdw 39 16 in in IN cord-020235-stcrozdw 39 17 the the DT cord-020235-stcrozdw 39 18 cytoplasm cytoplasm NN cord-020235-stcrozdw 39 19 . . . cord-020235-stcrozdw 40 1 -Biophysical -biophysical JJ cord-020235-stcrozdw 40 2 properties property NNS cord-020235-stcrozdw 40 3 of of IN cord-020235-stcrozdw 40 4 HAV HAV NNP cord-020235-stcrozdw 40 5 particles particle NNS cord-020235-stcrozdw 40 6 extracted extract VBN cord-020235-stcrozdw 40 7 from from IN cord-020235-stcrozdw 40 8 infected infected JJ cord-020235-stcrozdw 40 9 cells cell NNS cord-020235-stcrozdw 40 10 were be VBD cord-020235-stcrozdw 40 11 comparable comparable JJ cord-020235-stcrozdw 40 12 to to IN cord-020235-stcrozdw 40 13 those those DT cord-020235-stcrozdw 40 14 described describe VBN cord-020235-stcrozdw 40 15 for for IN cord-020235-stcrozdw 40 16 HAV HAV NNP cord-020235-stcrozdw 40 17 extracted extract VBN cord-020235-stcrozdw 40 18 from from IN cord-020235-stcrozdw 40 19 human human JJ cord-020235-stcrozdw 40 20 stool stool NN cord-020235-stcrozdw 40 21 . . . cord-020235-stcrozdw 41 1 Those those DT cord-020235-stcrozdw 41 2 findings finding NNS cord-020235-stcrozdw 41 3 are be VBP cord-020235-stcrozdw 41 4 of of IN cord-020235-stcrozdw 41 5 importance importance NN cord-020235-stcrozdw 41 6 for for IN cord-020235-stcrozdw 41 7 preparation preparation NN cord-020235-stcrozdw 41 8 of of IN cord-020235-stcrozdw 41 9 large large JJ cord-020235-stcrozdw 41 10 amounts amount NNS cord-020235-stcrozdw 41 11 of of IN cord-020235-stcrozdw 41 12 HAV hav NN cord-020235-stcrozdw 41 13 for for IN cord-020235-stcrozdw 41 14 vaccine vaccine NN cord-020235-stcrozdw 41 15 . . . cord-020235-stcrozdw 42 1 production production NN cord-020235-stcrozdw 42 2 . . . cord-020235-stcrozdw 43 1 Max Max NNP cord-020235-stcrozdw 43 2 von von NNP cord-020235-stcrozdw 43 3 Pettenkofer Pettenkofer NNP cord-020235-stcrozdw 43 4 - - HYPH cord-020235-stcrozdw 43 5 Inst Inst NNP cord-020235-stcrozdw 43 6 . . . cord-020235-stcrozdw 44 1 u. u. NNP cord-020235-stcrozdw 44 2 Inst Inst NNP cord-020235-stcrozdw 44 3 . . . cord-020235-stcrozdw 45 1 f. f. NNP cord-020235-stcrozdw 45 2 Biochemie Biochemie NNP cord-020235-stcrozdw 45 3 d. d. NNP cord-020235-stcrozdw 45 4 Univ Univ NNP cord-020235-stcrozdw 45 5 . . . cord-020235-stcrozdw 46 1 D-8000 D-8000 NNP cord-020235-stcrozdw 46 2 Miinchen Miinchen NNP cord-020235-stcrozdw 46 3 2 2 CD cord-020235-stcrozdw 46 4 Cloning cloning NN cord-020235-stcrozdw 46 5 of of IN cord-020235-stcrozdw 46 6 Hepatitis Hepatitis NNP cord-020235-stcrozdw 46 7 A A NNP cord-020235-stcrozdw 46 8 Virus Virus NNP cord-020235-stcrozdw 46 9 Genomes Genomes NNPS cord-020235-stcrozdw 46 10 HELM HELM NNP cord-020235-stcrozdw 46 11 , , , cord-020235-stcrozdw 46 12 K. K. NNP cord-020235-stcrozdw 46 13 VON VON NNP cord-020235-stcrozdw 46 14 DER DER NNP cord-020235-stcrozdw 46 15 , , , cord-020235-stcrozdw 46 16 WINNACKER WINNACKER NNP cord-020235-stcrozdw 46 17 , , , cord-020235-stcrozdw 46 18 E. E. NNP cord-020235-stcrozdw 46 19 L. L. NNP cord-020235-stcrozdw 46 20 , , , cord-020235-stcrozdw 46 21 and and CC cord-020235-stcrozdw 46 22 DEINHARDT DEINHARDT NNP cord-020235-stcrozdw 46 23 , , , cord-020235-stcrozdw 46 24 F. F. NNP cord-020235-stcrozdw 46 25 Subgenomic Subgenomic NNP cord-020235-stcrozdw 46 26 fragments fragment NNS cord-020235-stcrozdw 46 27 of of IN cord-020235-stcrozdw 46 28 the the DT cord-020235-stcrozdw 46 29 genomic genomic JJ cord-020235-stcrozdw 46 30 RNA RNA NNP cord-020235-stcrozdw 46 31 of of IN cord-020235-stcrozdw 46 32 hepatitis hepatitis NNP cord-020235-stcrozdw 46 33 A A NNP cord-020235-stcrozdw 46 34 virus virus NN cord-020235-stcrozdw 46 35 ( ( -LRB- cord-020235-stcrozdw 46 36 HAV hav VB cord-020235-stcrozdw 46 37 ) ) -RRB- cord-020235-stcrozdw 46 38 were be VBD cord-020235-stcrozdw 46 39 cloned clone VBN cord-020235-stcrozdw 46 40 via via IN cord-020235-stcrozdw 46 41 eDNA edna RB cord-020235-stcrozdw 46 42 into into IN cord-020235-stcrozdw 46 43 Pst Pst NNP cord-020235-stcrozdw 46 44 1 1 CD cord-020235-stcrozdw 46 45 site site NN cord-020235-stcrozdw 46 46 of of IN cord-020235-stcrozdw 46 47 pBR pBR VBN cord-020235-stcrozdw 46 48 322 322 CD cord-020235-stcrozdw 46 49 . . . cord-020235-stcrozdw 47 1 By by IN cord-020235-stcrozdw 47 2 restriction restriction NN cord-020235-stcrozdw 47 3 enzyme enzyme NN cord-020235-stcrozdw 47 4 pattern pattern NN cord-020235-stcrozdw 47 5 analysis analysis NN cord-020235-stcrozdw 47 6 and and CC cord-020235-stcrozdw 47 7 hybridization hybridization NN cord-020235-stcrozdw 47 8 of of IN cord-020235-stcrozdw 47 9 the the DT cord-020235-stcrozdw 47 10 cloned clone VBN cord-020235-stcrozdw 47 11 HAV HAV NNP cord-020235-stcrozdw 47 12 DNA DNA NNP cord-020235-stcrozdw 47 13 with with IN cord-020235-stcrozdw 47 14 selected select VBN cord-020235-stcrozdw 47 15 fragments fragment NNS cord-020235-stcrozdw 47 16 of of IN cord-020235-stcrozdw 47 17 the the DT cord-020235-stcrozdw 47 18 HA HA NNP cord-020235-stcrozdw 47 19 V V NNP cord-020235-stcrozdw 47 20 RNA RNA NNP cord-020235-stcrozdw 47 21 it -PRON- PRP cord-020235-stcrozdw 47 22 was be VBD cord-020235-stcrozdw 47 23 determined determine VBN cord-020235-stcrozdw 47 24 that that IN cord-020235-stcrozdw 47 25 the the DT cord-020235-stcrozdw 47 26 major major JJ cord-020235-stcrozdw 47 27 part part NN cord-020235-stcrozdw 47 28 of of IN cord-020235-stcrozdw 47 29 the the DT cord-020235-stcrozdw 47 30 cloned clone VBN cord-020235-stcrozdw 47 31 HAV HAV NNP cord-020235-stcrozdw 47 32 DNA dna NN cord-020235-stcrozdw 47 33 fragments fragment NNS cord-020235-stcrozdw 47 34 are be VBP cord-020235-stcrozdw 47 35 located locate VBN cord-020235-stcrozdw 47 36 at at IN cord-020235-stcrozdw 47 37 the the DT cord-020235-stcrozdw 47 38 3 3 CD cord-020235-stcrozdw 47 39 ' ' NN cord-020235-stcrozdw 47 40 end end NN cord-020235-stcrozdw 47 41 of of IN cord-020235-stcrozdw 47 42 the the DT cord-020235-stcrozdw 47 43 genome genome NN cord-020235-stcrozdw 47 44 but but CC cord-020235-stcrozdw 47 45 a a DT cord-020235-stcrozdw 47 46 few few JJ cord-020235-stcrozdw 47 47 clones clone NNS cord-020235-stcrozdw 47 48 are be VBP cord-020235-stcrozdw 47 49 distributed distribute VBN cord-020235-stcrozdw 47 50 over over IN cord-020235-stcrozdw 47 51 the the DT cord-020235-stcrozdw 47 52 entire entire JJ cord-020235-stcrozdw 47 53 genome genome NN cord-020235-stcrozdw 47 54 . . . cord-020235-stcrozdw 48 1 we -PRON- PRP cord-020235-stcrozdw 48 2 have have VBP cord-020235-stcrozdw 48 3 now now RB cord-020235-stcrozdw 48 4 identified identify VBN cord-020235-stcrozdw 48 5 subtype subtype NN cord-020235-stcrozdw 48 6 specific specific JJ cord-020235-stcrozdw 48 7 sites site NNS cord-020235-stcrozdw 48 8 in in IN cord-020235-stcrozdw 48 9 HBV HBV NNP cord-020235-stcrozdw 48 10 - - HYPH cord-020235-stcrozdw 48 11 restriction restriction NN cord-020235-stcrozdw 48 12 map map NN cord-020235-stcrozdw 48 13 s. s. NNP cord-020235-stcrozdw 49 1 The the DT cord-020235-stcrozdw 49 2 maps map NNS cord-020235-stcrozdw 49 3 were be VBD cord-020235-stcrozdw 49 4 aligned align VBN cord-020235-stcrozdw 49 5 to to IN cord-020235-stcrozdw 49 6 the the DT cord-020235-stcrozdw 49 7 Eco Eco NNP cord-020235-stcrozdw 49 8 RI RI NNP cord-020235-stcrozdw 49 9 site site NN cord-020235-stcrozdw 49 10 . . . cord-020235-stcrozdw 50 1 Only only RB cord-020235-stcrozdw 50 2 subtype subtype NN cord-020235-stcrozdw 50 3 ay ay UH cord-020235-stcrozdw 50 4 revealed reveal VBD cord-020235-stcrozdw 50 5 one one CD cord-020235-stcrozdw 50 6 subtype subtype NN cord-020235-stcrozdw 50 7 specific specific JJ cord-020235-stcrozdw 50 8 site site NN cord-020235-stcrozdw 50 9 of of IN cord-020235-stcrozdw 50 10 each each DT cord-020235-stcrozdw 50 11 XbaI XbaI NNPS cord-020235-stcrozdw 50 12 ( ( -LRB- cord-020235-stcrozdw 50 13 2000 2000 CD cord-020235-stcrozdw 50 14 BP BP NNP cord-020235-stcrozdw 50 15 ) ) -RRB- cord-020235-stcrozdw 50 16 , , , cord-020235-stcrozdw 50 17 H H NNP cord-020235-stcrozdw 50 18 inelI inelI NNP cord-020235-stcrozdw 50 19 ( ( -LRB- cord-020235-stcrozdw 50 20 2200 2200 CD cord-020235-stcrozdw 50 21 BP BP NNP cord-020235-stcrozdw 50 22 ) ) -RRB- cord-020235-stcrozdw 50 23 and and CC cord-020235-stcrozdw 50 24 Bam Bam NNP cord-020235-stcrozdw 50 25 HI HI NNP cord-020235-stcrozdw 50 26 ( ( -LRB- cord-020235-stcrozdw 50 27 2900 2900 CD cord-020235-stcrozdw 50 28 BP BP NNP cord-020235-stcrozdw 50 29 ) ) -RRB- cord-020235-stcrozdw 50 30 . . . cord-020235-stcrozdw 51 1 They -PRON- PRP cord-020235-stcrozdw 51 2 are be VBP cord-020235-stcrozdw 51 3 situ situ VBG cord-020235-stcrozdw 51 4 ated ate VBN cord-020235-stcrozdw 51 5 outside outside IN cord-020235-stcrozdw 51 6 the the DT cord-020235-stcrozdw 51 7 s s NN cord-020235-stcrozdw 51 8 - - HYPH cord-020235-stcrozdw 51 9 gene gene NN cord-020235-stcrozdw 51 10 . . . cord-020235-stcrozdw 52 1 Employing employ VBG cord-020235-stcrozdw 52 2 rhis rhis NNP cord-020235-stcrozdw 52 3 system system NN cord-020235-stcrozdw 52 4 the the DT cord-020235-stcrozdw 52 5 subty subty NNP cord-020235-stcrozdw 52 6 pes pes NNP cord-020235-stcrozdw 52 7 of of IN cord-020235-stcrozdw 52 8 three three CD cord-020235-stcrozdw 52 9 HBV HBV NNP cord-020235-stcrozdw 52 10 - - HYPH cord-020235-stcrozdw 52 11 ONA ONA NNP cord-020235-stcrozdw 52 12 sequences sequence NNS cord-020235-stcrozdw 52 13 that that WDT cord-020235-stcrozdw 52 14 ha ha UH cord-020235-stcrozdw 52 15 ve ve VBD cord-020235-stcrozdw 52 16 been be VBN cord-020235-stcrozdw 52 17 published publish VBN cord-020235-stcrozdw 52 18 so so RB cord-020235-stcrozdw 52 19 far far RB cord-020235-stcrozdw 52 20 , , , cord-020235-stcrozdw 52 21 could could MD cord-020235-stcrozdw 52 22 be be VB cord-020235-stcrozdw 52 23 determined determine VBN cord-020235-stcrozdw 52 24 . . . cord-020235-stcrozdw 53 1 Thereupon thereupon RB cord-020235-stcrozdw 53 2 the the DT cord-020235-stcrozdw 53 3 first first JJ cord-020235-stcrozdw 53 4 54 54 CD cord-020235-stcrozdw 53 5 triplets triplet NNS cord-020235-stcrozdw 53 6 of of IN cord-020235-stcrozdw 53 7 a a DT cord-020235-stcrozdw 53 8 HBV HBV NNP cord-020235-stcrozdw 53 9 ( ( -LRB- cord-020235-stcrozdw 53 10 ad)-DNA ad)-DNA NNP cord-020235-stcrozdw 53 11 sequence sequence NN cord-020235-stcrozdw 53 12 of of IN cord-020235-stcrozdw 53 13 the the DT cord-020235-stcrozdw 53 14 s s NN cord-020235-stcrozdw 53 15 - - HYPH cord-020235-stcrozdw 53 16 gene gene NN cord-020235-stcrozdw 53 17 could could MD cord-020235-stcrozdw 53 18 be be VB cord-020235-stcrozdw 53 19 com com NN cord-020235-stcrozdw 53 20 pared pare VBN cord-020235-stcrozdw 53 21 with with IN cord-020235-stcrozdw 53 22 pub pub NNP cord-020235-stcrozdw 53 23 lished lished NNP cord-020235-stcrozdw 53 24 data data NNP cord-020235-stcrozdw 53 25 . . . cord-020235-stcrozdw 54 1 Nucleotide nucleotide JJ cord-020235-stcrozdw 54 2 exchanges exchange NNS cord-020235-stcrozdw 54 3 in in IN cord-020235-stcrozdw 54 4 triplets triplet NNS cord-020235-stcrozdw 54 5 12 12 CD cord-020235-stcrozdw 54 6 and and CC cord-020235-stcrozdw 54 7 13 13 CD cord-020235-stcrozdw 54 8 did do VBD cord-020235-stcrozdw 54 9 not not RB cord-020235-stcrozdw 54 10 cau cau NNP cord-020235-stcrozdw 54 11 se se FW cord-020235-stcrozdw 54 12 an an DT cord-020235-stcrozdw 54 13 amino amino NN cord-020235-stcrozdw 54 14 - - HYPH cord-020235-stcrozdw 54 15 acid acid NN cord-020235-stcrozdw 54 16 ( ( -LRB- cord-020235-stcrozdw 54 17 aa)-exchange aa)-exchange NNP cord-020235-stcrozdw 54 18 , , , cord-020235-stcrozdw 54 19 bu bu NNP cord-020235-stcrozdw 54 20 t t NNP cord-020235-stcrozdw 54 21 cha cha NNP cord-020235-stcrozdw 54 22 nges nge NNS cord-020235-stcrozdw 54 23 in in IN cord-020235-stcrozdw 54 24 the the DT cord-020235-stcrozdw 54 25 triplets triplet NNS cord-020235-stcrozdw 54 26 45 45 CD cord-020235-stcrozdw 54 27 and and CC cord-020235-stcrozdw 54 28 46 46 CD cord-020235-stcrozdw 54 29 do do VBP cord-020235-stcrozdw 54 30 cause cause VB cord-020235-stcrozdw 54 31 such such JJ cord-020235-stcrozdw 54 32 exchange exchange NN cord-020235-stcrozdw 54 33 . . . cord-020235-stcrozdw 55 1 Thus thus RB cord-020235-stcrozdw 55 2 , , , cord-020235-stcrozdw 55 3 in in IN cord-020235-stcrozdw 55 4 subtype subtype NN cord-020235-stcrozdw 55 5 ay ay UH cord-020235-stcrozdw 55 6 , , , cord-020235-stcrozdw 55 7 aa aa NNP cord-020235-stcrozdw 55 8 45 45 CD cord-020235-stcrozdw 55 9 is be VBZ cord-020235-stcrozdw 55 10 thr thr NNP cord-020235-stcrozdw 55 11 , , , cord-020235-stcrozdw 55 12 and and CC cord-020235-stcrozdw 55 13 aa aa NNP cord-020235-stcrozdw 55 14 46 46 CD cord-020235-stcrozdw 55 15 is be VBZ cord-020235-stcrozdw 55 16 thr thr NNP cord-020235-stcrozdw 55 17 , , , cord-020235-stcrozdw 55 18 wh wh NNP cord-020235-stcrozdw 55 19 ile ile NNP cord-020235-stcrozdw 56 1 in in IN cord-020235-stcrozdw 56 2 subtype subtype NN cord-020235-stcrozdw 56 3 ad ad NN cord-020235-stcrozdw 56 4 , , , cord-020235-stcrozdw 56 5 aa aa NNP cord-020235-stcrozdw 56 6 45 45 CD cord-020235-stcrozdw 56 7 is be VBZ cord-020235-stcrozdw 56 8 ser ser NNP cord-020235-stcrozdw 56 9 and and CC cord-020235-stcrozdw 56 10 aa aa NNP cord-020235-stcrozdw 56 11 46 46 CD cord-020235-stcrozdw 56 12 is be VBZ cord-020235-stcrozdw 56 13 pro pro JJ cord-020235-stcrozdw 56 14 . . . cord-020235-stcrozdw 57 1 These these DT cord-020235-stcrozdw 57 2 exchanges exchange NNS cord-020235-stcrozdw 57 3 may may MD cord-020235-stcrozdw 57 4 produce produce VB cord-020235-stcrozdw 57 5 different different JJ cord-020235-stcrozdw 57 6 conf conf NN cord-020235-stcrozdw 57 7 ormation ormation NN cord-020235-stcrozdw 57 8 of of IN cord-020235-stcrozdw 57 9 th th XX cord-020235-stcrozdw 57 10 e e NN cord-020235-stcrozdw 57 11 peptides peptide NNS cord-020235-stcrozdw 57 12 . . . cord-020235-stcrozdw 58 1 Dept Dept NNP cord-020235-stcrozdw 58 2 . . . cord-020235-stcrozdw 59 1 M M NNP cord-020235-stcrozdw 59 2 ed ed NNP cord-020235-stcrozdw 59 3 . . . cord-020235-stcrozdw 60 1 Mic Mic NNP cord-020235-stcrozdw 60 2 robio robio NNP cord-020235-stcrozdw 60 3 l. l. NNP cord-020235-stcrozdw 60 4 , , , cord-020235-stcrozdw 60 5 Univ Univ NNP cord-020235-stcrozdw 60 6 . . NNP cord-020235-stcrozdw 60 7 0 0 NFP cord-020235-stcrozdw 61 1 -3400 -3400 : cord-020235-stcrozdw 62 1 Gottingen Gottingen NNP cord-020235-stcrozdw 62 2 Characterization characterization NN cord-020235-stcrozdw 62 3 of of IN cord-020235-stcrozdw 62 4 the the DT cord-020235-stcrozdw 62 5 Hepatitis Hepatitis NNP cord-020235-stcrozdw 62 6 B B NNP cord-020235-stcrozdw 62 7 Virus Virus NNP cord-020235-stcrozdw 62 8 ( ( -LRB- cord-020235-stcrozdw 62 9 HBV HBV NNP cord-020235-stcrozdw 62 10 ) ) -RRB- cord-020235-stcrozdw 63 1 Associated Associated NNP cord-020235-stcrozdw 63 2 Proteinkinase Proteinkinase NNP cord-020235-stcrozdw 63 3 GERLICH GERLICH NNP cord-020235-stcrozdw 63 4 , , , cord-020235-stcrozdw 63 5 W. W. NNP cord-020235-stcrozdw 63 6 H. H. NNP cord-020235-stcrozdw 63 7 Purified Purified NNP cord-020235-stcrozdw 63 8 HBV HBV NNP cord-020235-stcrozdw 63 9 - - HYPH cord-020235-stcrozdw 63 10 core core NN cord-020235-stcrozdw 63 11 preparations preparation NNS cord-020235-stcrozdw 63 12 were be VBD cord-020235-stcrozdw 63 13 shown show VBN cord-020235-stcrozdw 63 14 to to TO cord-020235-stcrozdw 63 15 contain contain VB cord-020235-stcrozdw 63 16 a a DT cord-020235-stcrozdw 63 17 pr pr NNP cord-020235-stcrozdw 63 18 ot ot NNP cord-020235-stcrozdw 63 19 eink eink NNP cord-020235-stcrozdw 63 20 inase inase NNP cord-020235-stcrozdw 63 21 which which WDT cord-020235-stcrozdw 63 22 phosphory phosphory NNP cord-020235-stcrozdw 63 23 lates late VBZ cord-020235-stcrozdw 63 24 the the DT cord-020235-stcrozdw 63 25 major major JJ cord-020235-stcrozdw 63 26 core core NN cord-020235-stcrozdw 63 27 protein protein NN cord-020235-stcrozdw 63 28 ( ( -LRB- cord-020235-stcrozdw 63 29 Albin Albin NNP cord-020235-stcrozdw 63 30 and and CC cord-020235-stcrozdw 63 31 Robinson Robinson NNP cord-020235-stcrozdw 63 32 , , , cord-020235-stcrozdw 63 33 1980 1980 CD cord-020235-stcrozdw 63 34 ) ) -RRB- cord-020235-stcrozdw 63 35 . . . cord-020235-stcrozdw 64 1 In in IN cord-020235-stcrozdw 64 2 this this DT cord-020235-stcrozdw 64 3 study study NN cord-020235-stcrozdw 64 4 it -PRON- PRP cord-020235-stcrozdw 64 5 was be VBD cord-020235-stcrozdw 64 6 found find VBN cord-020235-stcrozdw 64 7 th th XX cord-020235-stcrozdw 64 8 at at IN cord-020235-stcrozdw 64 9 th th XX cord-020235-stcrozdw 64 10 is be VBZ cord-020235-stcrozdw 64 11 enzyme enzyme JJ cord-020235-stcrozdw 64 12 copurifies copurifie NNS cord-020235-stcrozdw 64 13 with with IN cord-020235-stcrozdw 64 14 the the DT cord-020235-stcrozdw 64 15 light light NN cord-020235-stcrozdw 64 16 ( ( -LRB- cord-020235-stcrozdw 64 17 d d NN cord-020235-stcrozdw 64 18 = = SYM cord-020235-stcrozdw 64 19 1.31 1.31 CD cord-020235-stcrozdw 64 20 ) ) -RRB- cord-020235-stcrozdw 65 1 but but CC cord-020235-stcrozdw 65 2 not not RB cord-020235-stcrozdw 65 3 with with IN cord-020235-stcrozdw 65 4 the the DT cord-020235-stcrozdw 65 5 heavy heavy JJ cord-020235-stcrozdw 65 6 subfraction subfraction NN cord-020235-stcrozdw 65 7 ( ( -LRB- cord-020235-stcrozdw 65 8 d d NN cord-020235-stcrozdw 65 9 = = SYM cord-020235-stcrozdw 65 10 1.35 1.35 CD cord-020235-stcrozdw 65 11 ) ) -RRB- cord-020235-stcrozdw 65 12 of of IN cord-020235-stcrozdw 65 13 the the DT cord-020235-stcrozdw 65 14 core core NN cord-020235-stcrozdw 65 15 - - HYPH cord-020235-stcrozdw 65 16 particles particle NNS cord-020235-stcrozdw 65 17 . . . cord-020235-stcrozdw 66 1 The the DT cord-020235-stcrozdw 66 2 enzyme enzyme NN cord-020235-stcrozdw 66 3 has have VBZ cord-020235-stcrozdw 66 4 a a DT cord-020235-stcrozdw 66 5 high high JJ cord-020235-stcrozdw 66 6 affinity affinity NN cord-020235-stcrozdw 66 7 for for IN cord-020235-stcrozdw 66 8 ATP ATP NNP cord-020235-stcrozdw 66 9 and and CC cord-020235-stcrozdw 66 10 it -PRON- PRP cord-020235-stcrozdw 66 11 transfers transfer VBZ cord-020235-stcrozdw 66 12 approx approx NN cord-020235-stcrozdw 66 13 . . . cord-020235-stcrozdw 67 1 one one CD cord-020235-stcrozdw 67 2 ph ph NN cord-020235-stcrozdw 67 3 osphat osphat NNP cord-020235-stcrozdw 67 4 e e NN cord-020235-stcrozdw 67 5 per per IN cord-020235-stcrozdw 67 6 particle particle NN cord-020235-stcrozdw 67 7 within within IN cord-020235-stcrozdw 67 8 minutes minute NNS cord-020235-stcrozdw 67 9 . . . cord-020235-stcrozdw 68 1 The the DT cord-020235-stcrozdw 68 2 32P 32p CD cord-020235-stcrozdw 68 3 - - HYPH cord-020235-stcrozdw 68 4 phosphate phosphate NN cord-020235-stcrozdw 68 5 introd introd NN cord-020235-stcrozdw 68 6 uced uce VBN cord-020235-stcrozdw 68 7 in in IN cord-020235-stcrozdw 68 8 vitro vitro FW cord-020235-stcrozdw 68 9 can can MD cord-020235-stcrozdw 68 10 not not RB cord-020235-stcrozdw 68 11 be be VB cord-020235-stcrozdw 68 12 remove remove VB cord-020235-stcrozdw 68 13 d d NN cord-020235-stcrozdw 68 14 from from IN cord-020235-stcrozdw 68 15 core core NN cord-020235-stcrozdw 68 16 - - HYPH cord-020235-stcrozdw 68 17 particles particle NNS cord-020235-stcrozdw 68 18 by by IN cord-020235-stcrozdw 68 19 digestion digestion NN cord-020235-stcrozdw 68 20 with with IN cord-020235-stcrozdw 68 21 alkaline alkaline JJ cord-020235-stcrozdw 68 22 ph ph NNP cord-020235-stcrozdw 68 23 osph osph NNP cord-020235-stcrozdw 68 24 at at IN cord-020235-stcrozdw 68 25 ase ase NNP cord-020235-stcrozdw 68 26 . . . cord-020235-stcrozdw 69 1 After after IN cord-020235-stcrozdw 69 2 lysis lysis NN cord-020235-stcrozdw 69 3 of of IN cord-020235-stcrozdw 69 4 the the DT cord-020235-stcrozdw 69 5 cores core NNS cord-020235-stcrozdw 69 6 with with IN cord-020235-stcrozdw 69 7 SOS SOS NNP cord-020235-stcrozdw 69 8 the the DT cord-020235-stcrozdw 69 9 32p 32p NNS cord-020235-stcrozdw 69 10 can can MD cord-020235-stcrozdw 69 11 be be VB cord-020235-stcrozdw 69 12 cleaved cleave VBN cord-020235-stcrozdw 69 13 from from IN cord-020235-stcrozdw 69 14 rhe rhe JJ cord-020235-stcrozdw 69 15 protein protein NN cord-020235-stcrozdw 69 16 . . . cord-020235-stcrozdw 70 1 T T NNP cord-020235-stcrozdw 70 2 his -PRON- PRP$ cord-020235-stcrozdw 70 3 suggests suggest VBZ cord-020235-stcrozdw 70 4 th th XX cord-020235-stcrozdw 70 5 at at IN cord-020235-stcrozdw 70 6 th th XX cord-020235-stcrozdw 70 7 e e NN cord-020235-stcrozdw 70 8 enzyme enzyme NN cord-020235-stcrozdw 70 9 and and CC cord-020235-stcrozdw 70 10 its -PRON- PRP$ cord-020235-stcrozdw 70 11 ph ph NNP cord-020235-stcrozdw 70 12 osphate osphate NNP cord-020235-stcrozdw 70 13 acceptor acceptor NN cord-020235-stcrozdw 70 14 site site NN cord-020235-stcrozdw 70 15 are be VBP cord-020235-stcrozdw 70 16 located locate VBN cord-020235-stcrozdw 70 17 with with IN cord-020235-stcrozdw 70 18 in in IN cord-020235-stcrozdw 70 19 the the DT cord-020235-stcrozdw 70 20 pa pa NNP cord-020235-stcrozdw 70 21 rticle rticle NNP cord-020235-stcrozdw 70 22 . . . cord-020235-stcrozdw 71 1 After after IN cord-020235-stcrozdw 71 2 acid acid NN cord-020235-stcrozdw 71 3 hydrolysis hydrolysis NN cord-020235-stcrozdw 72 1 the the DT cord-020235-stcrozdw 72 2 incor incor NNP cord-020235-stcrozdw 72 3 porated porated NNP cord-020235-stcrozdw 73 1 3!P 3!P NNP cord-020235-stcrozdw 73 2 co co NNS cord-020235-stcrozdw 73 3 - - NN cord-020235-stcrozdw 73 4 migrates migrate NNS cord-020235-stcrozdw 74 1 with with IN cord-020235-stcrozdw 74 2 ph ph NNP cord-020235-stcrozdw 74 3 osph osph FW cord-020235-stcrozdw 74 4 oserin oserin NNP cord-020235-stcrozdw 74 5 but but CC cord-020235-stcrozdw 74 6 not not RB cord-020235-stcrozdw 74 7 with with IN cord-020235-stcrozdw 74 8 phosphor phosphor NN cord-020235-stcrozdw 74 9 hreonin hreonin NNP cord-020235-stcrozdw 74 10 or or CC cord-020235-stcrozdw 74 11 phos phos NNP cord-020235-stcrozdw 74 12 pho pho NNP cord-020235-stcrozdw 74 13 tryosin tryosin NNP cord-020235-stcrozdw 74 14 . . . cord-020235-stcrozdw 75 1 M M NNP cord-020235-stcrozdw 75 2 ax ax NNP cord-020235-stcrozdw 75 3 von von NNP cord-020235-stcrozdw 75 4 Petrenk Petrenk NNP cord-020235-stcrozdw 75 5 ofer ofer NNP cord-020235-stcrozdw 75 6 - - HYPH cord-020235-stcrozdw 75 7 Inst Inst NNP cord-020235-stcrozdw 75 8 . . . cord-020235-stcrozdw 76 1 , , , cord-020235-stcrozdw 76 2 Univ Univ NNP cord-020235-stcrozdw 76 3 . . NNP cord-020235-stcrozdw 76 4 0 0 CD cord-020235-stcrozdw 76 5 -8000 -8000 NN cord-020235-stcrozdw 76 6 Miin Miin NNP cord-020235-stcrozdw 76 7 chen chen NNP cord-020235-stcrozdw 76 8 2 2 CD cord-020235-stcrozdw 77 1 A a DT cord-020235-stcrozdw 77 2 Phosphokinase Phosphokinase NNP cord-020235-stcrozdw 77 3 Activity activity NN cord-020235-stcrozdw 78 1 Associated associate VBN cord-020235-stcrozdw 78 2 With with IN cord-020235-stcrozdw 78 3 the the DT cord-020235-stcrozdw 78 4 Hepatitis Hepatitis NNP cord-020235-stcrozdw 78 5 B B NNP cord-020235-stcrozdw 78 6 Virus Virus NNP cord-020235-stcrozdw 78 7 ( ( -LRB- cord-020235-stcrozdw 78 8 HBV HBV NNP cord-020235-stcrozdw 78 9 ) ) -RRB- cord-020235-stcrozdw 79 1 Core Core NNP cord-020235-stcrozdw 79 2 HELM HELM NNP cord-020235-stcrozdw 79 3 , , , cord-020235-stcrozdw 79 4 K. K. NNP cord-020235-stcrozdw 79 5 VON VON NNP cord-020235-stcrozdw 79 6 DER DER NNP cord-020235-stcrozdw 79 7 , , , cord-020235-stcrozdw 79 8 ROGGENDORF ROGGENDORF NNP cord-020235-stcrozdw 79 9 , , , cord-020235-stcrozdw 79 10 M. M. NNP cord-020235-stcrozdw 79 11 , , , cord-020235-stcrozdw 79 12 and and CC cord-020235-stcrozdw 79 13 SIEGERT SIEGERT NNP cord-020235-stcrozdw 79 14 , , , cord-020235-stcrozdw 79 15 W. W. NNP cord-020235-stcrozdw 79 16 Prepar Prepar NNP cord-020235-stcrozdw 79 17 ation ation NN cord-020235-stcrozdw 79 18 s s NN cord-020235-stcrozdw 79 19 of of IN cord-020235-stcrozdw 80 1 core core NN cord-020235-stcrozdw 80 2 antigen antigen NN cord-020235-stcrozdw 80 3 positive positive JJ cord-020235-stcrozdw 80 4 ( ( -LRB- cord-020235-stcrozdw 80 5 HBcAg hbcag CD cord-020235-stcrozdw 80 6 ) ) -RRB- cord-020235-stcrozdw 80 7 fractions fraction NNS cord-020235-stcrozdw 80 8 obta obta VBN cord-020235-stcrozdw 80 9 ined ine VBN cord-020235-stcrozdw 80 10 from from IN cord-020235-stcrozdw 80 11 HBV HBV NNP cord-020235-stcrozdw 81 1 positive positive JJ cord-020235-stcrozdw 81 2 hu hu NNP cord-020235-stcrozdw 81 3 man man NN cord-020235-stcrozdw 81 4 liver liver NN cord-020235-stcrozdw 81 5 tissue tissue NN cord-020235-stcrozdw 81 6 are be VBP cord-020235-stcrozdw 81 7 associated associate VBN cord-020235-stcrozdw 81 8 with with IN cord-020235-stcrozdw 81 9 a a DT cord-020235-stcrozdw 81 10 ph ph NNP cord-020235-stcrozdw 81 11 osphokinase osphokinase NNP cord-020235-stcrozdw 81 12 wh wh NNP cord-020235-stcrozdw 81 13 ich ich NNP cord-020235-stcrozdw 81 14 copurifies copurifies NNP cord-020235-stcrozdw 81 15 with with IN cord-020235-stcrozdw 81 16 the the DT cord-020235-stcrozdw 81 17 HBcAg hbcag CD cord-020235-stcrozdw 81 18 in in IN cord-020235-stcrozdw 81 19 CsCl CsCl NNP cord-020235-stcrozdw 81 20 density density NN cord-020235-stcrozdw 81 21 - - HYPH cord-020235-stcrozdw 81 22 and and CC cord-020235-stcrozdw 81 23 sucrose sucrose NN cord-020235-stcrozdw 81 24 velocity velocity NN cord-020235-stcrozdw 81 25 grad grad NN cord-020235-stcrozdw 81 26 ient ient NNP cord-020235-stcrozdw 81 27 centrifugations centrifugation NNS cord-020235-stcrozdw 81 28 . . . cord-020235-stcrozdw 82 1 The the DT cord-020235-stcrozdw 82 2 acceptor acceptor NN cord-020235-stcrozdw 82 3 protein protein NN cord-020235-stcrozdw 82 4 for for IN cord-020235-stcrozdw 82 5 this this DT cord-020235-stcrozdw 82 6 kina kina NNP cord-020235-stcrozdw 82 7 se se FW cord-020235-stcrozdw 82 8 is be VBZ cord-020235-stcrozdw 82 9 the the DT cord-020235-stcrozdw 82 10 19000 19000 CD cord-020235-stcrozdw 82 11 d d NN cord-020235-stcrozdw 82 12 HBcAg hbcag CD cord-020235-stcrozdw 82 13 protein protein NN cord-020235-stcrozdw 82 14 ; ; . cord-020235-stcrozdw 83 1 casein casein NNP cord-020235-stcrozdw 83 2 as as IN cord-020235-stcrozdw 83 3 an an DT cord-020235-stcrozdw 83 4 exogenous exogenous JJ cord-020235-stcrozdw 83 5 acceptor acceptor NN cord-020235-stcrozdw 83 6 is be VBZ cord-020235-stcrozdw 83 7 also also RB cord-020235-stcrozdw 83 8 phospho phospho NNP cord-020235-stcrozdw 83 9 rylate rylate NNP cord-020235-stcrozdw 83 10 d d NNP cord-020235-stcrozdw 83 11 to to IN cord-020235-stcrozdw 83 12 a a DT cord-020235-stcrozdw 83 13 minor minor JJ cord-020235-stcrozdw 83 14 extend extend NN cord-020235-stcrozdw 83 15 . . . cord-020235-stcrozdw 84 1 The the DT cord-020235-stcrozdw 84 2 ph ph NNP cord-020235-stcrozdw 84 3 osphorylated osphorylate VBN cord-020235-stcrozdw 84 4 amino amino NN cord-020235-stcrozdw 84 5 acid acid NN cord-020235-stcrozdw 84 6 is be VBZ cord-020235-stcrozdw 84 7 serine serine NN cord-020235-stcrozdw 84 8 or or CC cord-020235-stcrozdw 84 9 threonine threonine NN cord-020235-stcrozdw 84 10 and and CC cord-020235-stcrozdw 84 11 not not RB cord-020235-stcrozdw 84 12 tyrosi tyrosi NNP cord-020235-stcrozdw 84 13 ne ne NNP cord-020235-stcrozdw 84 14 , , , cord-020235-stcrozdw 84 15 as as IN cord-020235-stcrozdw 84 16 it -PRON- PRP cord-020235-stcrozdw 84 17 is be VBZ cord-020235-stcrozdw 84 18 frequently frequently RB cord-020235-stcrozdw 84 19 the the DT cord-020235-stcrozdw 84 20 case case NN cord-020235-stcrozdw 84 21 with with IN cord-020235-stcrozdw 84 22 tumor tumor NN cord-020235-stcrozdw 84 23 virus virus NN cord-020235-stcrozdw 84 24 specific specific JJ cord-020235-stcrozdw 84 25 prot prot FW cord-020235-stcrozdw 84 26 ein ein FW cord-020235-stcrozdw 84 27 kinases kinase NNS cord-020235-stcrozdw 84 28 . . . cord-020235-stcrozdw 85 1 Dept Dept NNP cord-020235-stcrozdw 85 2 . . . cord-020235-stcrozdw 86 1 Med Med NNP cord-020235-stcrozdw 86 2 . . . cord-020235-stcrozdw 86 3 Microbiol Microbiol NNP cord-020235-stcrozdw 86 4 . . NNP cord-020235-stcrozdw 86 5 , , , cord-020235-stcrozdw 86 6 Univ Univ NNP cord-020235-stcrozdw 86 7 . . NNP cord-020235-stcrozdw 86 8 0 0 NFP cord-020235-stcrozdw 87 1 -3400 -3400 : cord-020235-stcrozdw 88 1 Gott Gott NNP cord-020235-stcrozdw 88 2 ingen ingen NNP cord-020235-stcrozdw 88 3 Effect Effect NNP cord-020235-stcrozdw 88 4 of of IN cord-020235-stcrozdw 88 5 Glycosidases Glycosidases NNP cord-020235-stcrozdw 88 6 on on IN cord-020235-stcrozdw 88 7 the the DT cord-020235-stcrozdw 88 8 Proteins protein NNS cord-020235-stcrozdw 88 9 of of IN cord-020235-stcrozdw 88 10 Hepatitis Hepatitis NNP cord-020235-stcrozdw 88 11 B B NNP cord-020235-stcrozdw 88 12 Surface Surface NNP cord-020235-stcrozdw 88 13 Antigen Antigen NNP cord-020235-stcrozdw 88 14 ( ( -LRB- cord-020235-stcrozdw 88 15 HBsAg hbsag ADD cord-020235-stcrozdw 88 16 ) ) -RRB- cord-020235-stcrozdw 88 17 STIBBE STIBBE NNP cord-020235-stcrozdw 88 18 , , , cord-020235-stcrozdw 88 19 W. W. NNP cord-020235-stcrozdw 88 20 and and CC cord-020235-stcrozdw 88 21 GERLICH GERLICH NNP cord-020235-stcrozdw 88 22 , , , cord-020235-stcrozdw 88 23 W. W. NNP cord-020235-stcrozdw 88 24 H H NNP cord-020235-stcrozdw 88 25 . . . cord-020235-stcrozdw 89 1 The the DT cord-020235-stcrozdw 89 2 protein protein NN cord-020235-stcrozdw 89 3 composition composition NN cord-020235-stcrozdw 89 4 of of IN cord-020235-stcrozdw 89 5 purified purify VBN cord-020235-stcrozdw 89 6 HBsAg HBsAg NNP cord-020235-stcrozdw 89 7 was be VBD cord-020235-stcrozdw 89 8 stud stud NN cord-020235-stcrozdw 89 9 ied ie VBN cord-020235-stcrozdw 89 10 by by IN cord-020235-stcrozdw 89 11 SOS·gc1e1ectrophoresis sos·gc1e1ectrophoresis NN cord-020235-stcrozdw 89 12 and and CC cord-020235-stcrozdw 89 13 staining stain VBG cord-020235-stcrozdw 89 14 with with IN cord-020235-stcrozdw 89 15 silver silver NN cord-020235-stcrozdw 89 16 . . . cord-020235-stcrozdw 90 1 In in IN cord-020235-stcrozdw 90 2 additio additio NNP cord-020235-stcrozdw 90 3 n n NN cord-020235-stcrozdw 90 4 to to IN cord-020235-stcrozdw 90 5 P25 P25 NNP cord-020235-stcrozdw 90 6 and and CC cord-020235-stcrozdw 90 7 GP28 GP28 NNP cord-020235-stcrozdw 90 8 of of IN cord-020235-stcrozdw 90 9 HBsAg hbsag ADD cord-020235-stcrozdw 90 10 two two CD cord-020235-stcrozdw 90 11 furt furt NNP cord-020235-stcrozdw 90 12 her -PRON- PRP$ cord-020235-stcrozdw 90 13 proteins protein NNS cord-020235-stcrozdw 90 14 , , , cord-020235-stcrozdw 90 15 GP33 GP33 NNP cord-020235-stcrozdw 90 16 and and CC cord-020235-stcrozdw 90 17 GP36 GP36 NNP cord-020235-stcrozdw 90 18 , , , cord-020235-stcrozdw 90 19 were be VBD cord-020235-stcrozdw 90 20 found find VBN cord-020235-stcrozdw 90 21 consistently consistently RB cord-020235-stcrozdw 90 22 in in IN cord-020235-stcrozdw 90 23 preparations preparation NNS cord-020235-stcrozdw 90 24 from from IN cord-020235-stcrozdw 90 25 9 9 CD cord-020235-stcrozdw 90 26 different different JJ cord-020235-stcrozdw 90 27 blood blood NN cord-020235-stcrozdw 90 28 donors donor NNS cord-020235-stcrozdw 90 29 . . . cord-020235-stcrozdw 91 1 The the DT cord-020235-stcrozdw 91 2 glycoprotein glycoprotein NN cord-020235-stcrozdw 91 3 nature nature NN cord-020235-stcrozdw 91 4 of of IN cord-020235-stcrozdw 91 5 GP GP NNP cord-020235-stcrozdw 91 6 33 33 CD cord-020235-stcrozdw 91 7 and and CC cord-020235-stcrozdw 91 8 GP GP NNP cord-020235-stcrozdw 91 9 36 36 CD cord-020235-stcrozdw 91 10 was be VBD cord-020235-stcrozdw 91 11 shown show VBN cord-020235-stcrozdw 91 12 by by IN cord-020235-stcrozdw 91 13 the the DT cord-020235-stcrozdw 91 14 increase increase NN cord-020235-stcrozdw 91 15 of of IN cord-020235-stcrozdw 91 16 electrophoretic electrophoretic JJ cord-020235-stcrozdw 91 17 mobility mobility NN cord-020235-stcrozdw 91 18 after after IN cord-020235-stcrozdw 91 19 treatment treatment NN cord-020235-stcrozdw 91 20 with with IN cord-020235-stcrozdw 91 21 endoglycosidase endoglycosidase NNP cord-020235-stcrozdw 91 22 H H NNP cord-020235-stcrozdw 91 23 or or CC cord-020235-stcrozdw 91 24 neuraminidase neuraminidase NN cord-020235-stcrozdw 91 25 . . . cord-020235-stcrozdw 92 1 Immune immune JJ cord-020235-stcrozdw 92 2 precipitation precipitation NN cord-020235-stcrozdw 92 3 with with IN cord-020235-stcrozdw 92 4 anti anti JJ cord-020235-stcrozdw 92 5 - - JJ cord-020235-stcrozdw 92 6 HBs hb NNS cord-020235-stcrozdw 92 7 in in IN cord-020235-stcrozdw 92 8 RIPA RIPA NNP cord-020235-stcrozdw 92 9 - - HYPH cord-020235-stcrozdw 92 10 buffer buffer NN cord-020235-stcrozdw 92 11 confirmed confirm VBD cord-020235-stcrozdw 92 12 the the DT cord-020235-stcrozdw 92 13 specifity specifity NN cord-020235-stcrozdw 92 14 of of IN cord-020235-stcrozdw 92 15 the the DT cord-020235-stcrozdw 92 16 glycoproteins glycoprotein NNS cord-020235-stcrozdw 92 17 , , , cord-020235-stcrozdw 92 18 The the DT cord-020235-stcrozdw 92 19 change change NN cord-020235-stcrozdw 92 20 in in IN cord-020235-stcrozdw 92 21 apparent apparent JJ cord-020235-stcrozdw 92 22 mol mol NN cord-020235-stcrozdw 92 23 . . . cord-020235-stcrozdw 93 1 weight weight NN cord-020235-stcrozdw 93 2 after after IN cord-020235-stcrozdw 93 3 treatment treatment NN cord-020235-stcrozdw 93 4 with with IN cord-020235-stcrozdw 93 5 neuraminidase neuraminidase NN cord-020235-stcrozdw 93 6 was be VBD cord-020235-stcrozdw 93 7 larger large JJR cord-020235-stcrozdw 93 8 for for IN cord-020235-stcrozdw 93 9 GP36 GP36 NNP cord-020235-stcrozdw 93 10 ( ( -LRB- cord-020235-stcrozdw 93 11 900 900 CD cord-020235-stcrozdw 93 12 ) ) -RRB- cord-020235-stcrozdw 93 13 than than IN cord-020235-stcrozdw 93 14 for for IN cord-020235-stcrozdw 93 15 GP33 GP33 NNP cord-020235-stcrozdw 93 16 ( ( -LRB- cord-020235-stcrozdw 93 17 600 600 CD cord-020235-stcrozdw 93 18 ) ) -RRB- cord-020235-stcrozdw 93 19 or or CC cord-020235-stcrozdw 93 20 GP28 GP28 NNP cord-020235-stcrozdw 93 21 ( ( -LRB- cord-020235-stcrozdw 93 22 300 300 CD cord-020235-stcrozdw 93 23 ) ) -RRB- cord-020235-stcrozdw 93 24 . . . cord-020235-stcrozdw 94 1 The the DT cord-020235-stcrozdw 94 2 data datum NNS cord-020235-stcrozdw 94 3 suggest suggest VBP cord-020235-stcrozdw 94 4 that that IN cord-020235-stcrozdw 94 5 GP GP NNP cord-020235-stcrozdw 94 6 33 33 CD cord-020235-stcrozdw 94 7 and and CC cord-020235-stcrozdw 94 8 GP36 GP36 NNP cord-020235-stcrozdw 94 9 are be VBP cord-020235-stcrozdw 94 10 multiply multiply VB cord-020235-stcrozdw 94 11 glycosylated glycosylated JJ cord-020235-stcrozdw 94 12 proteins protein NNS cord-020235-stcrozdw 94 13 with with IN cord-020235-stcrozdw 94 14 N n CD cord-020235-stcrozdw 94 15 - - HYPH cord-020235-stcrozdw 94 16 glycosidic glycosidic NN cord-020235-stcrozdw 94 17 linked link VBN cord-020235-stcrozdw 94 18 carbohydrate carbohydrate NN cord-020235-stcrozdw 94 19 side side NN cord-020235-stcrozdw 94 20 chains chain NNS cord-020235-stcrozdw 94 21 of of IN cord-020235-stcrozdw 94 22 the the DT cord-020235-stcrozdw 94 23 mixed mixed JJ cord-020235-stcrozdw 94 24 type type NN cord-020235-stcrozdw 94 25 . . . cord-020235-stcrozdw 95 1 Inst Inst NNP cord-020235-stcrozdw 95 2 , , , cord-020235-stcrozdw 95 3 f. f. NN cord-020235-stcrozdw 95 4 Virologie Virologie NNP cord-020235-stcrozdw 95 5 , , , cord-020235-stcrozdw 95 6 Univ Univ NNP cord-020235-stcrozdw 95 7 . . NNP cord-020235-stcrozdw 95 8 , , , cord-020235-stcrozdw 96 1 HB HB NNP cord-020235-stcrozdw 96 2 s s POS cord-020235-stcrozdw 96 3 antigen antigen NN cord-020235-stcrozdw 96 4 screening screening NN cord-020235-stcrozdw 96 5 was be VBD cord-020235-stcrozdw 96 6 done do VBN cord-020235-stcrozdw 96 7 in in IN cord-020235-stcrozdw 96 8 the the DT cord-020235-stcrozdw 96 9 blood blood NN cord-020235-stcrozdw 96 10 samples sample NNS cord-020235-stcrozdw 96 11 of of IN cord-020235-stcrozdw 96 12 1,790 1,790 CD cord-020235-stcrozdw 96 13 pregnant pregnant JJ cord-020235-stcrozdw 96 14 women woman NNS cord-020235-stcrozdw 96 15 . . . cord-020235-stcrozdw 97 1 33 33 CD cord-020235-stcrozdw 97 2 blood blood NN cord-020235-stcrozdw 97 3 samples sample NNS cord-020235-stcrozdw 97 4 were be VBD cord-020235-stcrozdw 97 5 found find VBN cord-020235-stcrozdw 97 6 to to TO cord-020235-stcrozdw 97 7 be be VB cord-020235-stcrozdw 97 8 HB HB NNP cord-020235-stcrozdw 97 9 s s POS cord-020235-stcrozdw 97 10 antigen antigen NN cord-020235-stcrozdw 97 11 positive positive JJ cord-020235-stcrozdw 97 12 . . . cord-020235-stcrozdw 98 1 32 32 CD cord-020235-stcrozdw 98 2 women woman NNS cord-020235-stcrozdw 98 3 were be VBD cord-020235-stcrozdw 98 4 asymptomic asymptomic JJ cord-020235-stcrozdw 98 5 carriers carrier NNS cord-020235-stcrozdw 98 6 , , , cord-020235-stcrozdw 98 7 1 1 CD cord-020235-stcrozdw 98 8 woman woman NN cord-020235-stcrozdw 98 9 suffered suffer VBD cord-020235-stcrozdw 98 10 from from IN cord-020235-stcrozdw 98 11 chronic chronic JJ cord-020235-stcrozdw 98 12 hepatitis hepatitis NN cord-020235-stcrozdw 98 13 . . . cord-020235-stcrozdw 99 1 31 31 CD cord-020235-stcrozdw 99 2 children child NNS cord-020235-stcrozdw 99 3 have have VBP cord-020235-stcrozdw 99 4 been be VBN cord-020235-stcrozdw 99 5 born bear VBN cord-020235-stcrozdw 99 6 until until IN cord-020235-stcrozdw 99 7 now now RB cord-020235-stcrozdw 99 8 . . . cord-020235-stcrozdw 100 1 The the DT cord-020235-stcrozdw 100 2 examination examination NN cord-020235-stcrozdw 100 3 of of IN cord-020235-stcrozdw 100 4 cord cord NN cord-020235-stcrozdw 100 5 blood blood NN cord-020235-stcrozdw 100 6 showed show VBD cord-020235-stcrozdw 100 7 HB HB NNP cord-020235-stcrozdw 100 8 s s POS cord-020235-stcrozdw 100 9 antigen antigen NN cord-020235-stcrozdw 100 10 in in IN cord-020235-stcrozdw 100 11 6 6 CD cord-020235-stcrozdw 100 12 samples sample NNS cord-020235-stcrozdw 100 13 ; ; : cord-020235-stcrozdw 100 14 the the DT cord-020235-stcrozdw 100 15 venous venous JJ cord-020235-stcrozdw 100 16 blood blood NN cord-020235-stcrozdw 100 17 samples sample NNS cord-020235-stcrozdw 100 18 taken take VBN cord-020235-stcrozdw 100 19 thereupon thereupon RB cord-020235-stcrozdw 100 20 demonstrated demonstrate VBD cord-020235-stcrozdw 100 21 HB HB NNP cord-020235-stcrozdw 100 22 s s POS cord-020235-stcrozdw 100 23 antigen antigen NN cord-020235-stcrozdw 100 24 only only RB cord-020235-stcrozdw 100 25 in in IN cord-020235-stcrozdw 100 26 two two CD cord-020235-stcrozdw 100 27 samples sample NNS cord-020235-stcrozdw 100 28 . . . cord-020235-stcrozdw 101 1 The the DT cord-020235-stcrozdw 101 2 HB HB NNP cord-020235-stcrozdw 101 3 s s POS cord-020235-stcrozdw 101 4 antigen antigen NN cord-020235-stcrozdw 101 5 negative negative JJ cord-020235-stcrozdw 101 6 children child NNS cord-020235-stcrozdw 101 7 were be VBD cord-020235-stcrozdw 101 8 treated treat VBN cord-020235-stcrozdw 101 9 with with IN cord-020235-stcrozdw 101 10 HBIG HBIG NNP cord-020235-stcrozdw 101 11 . . . cord-020235-stcrozdw 102 1 The the DT cord-020235-stcrozdw 102 2 follow follow VB cord-020235-stcrozdw 102 3 - - HYPH cord-020235-stcrozdw 102 4 up up NN cord-020235-stcrozdw 102 5 examination examination NN cord-020235-stcrozdw 102 6 of of IN cord-020235-stcrozdw 102 7 the the DT cord-020235-stcrozdw 102 8 treated treat VBN cord-020235-stcrozdw 102 9 children child NNS cord-020235-stcrozdw 102 10 showed show VBD cord-020235-stcrozdw 102 11 no no DT cord-020235-stcrozdw 102 12 signs sign NNS cord-020235-stcrozdw 102 13 of of IN cord-020235-stcrozdw 102 14 infection infection NN cord-020235-stcrozdw 102 15 up up IN cord-020235-stcrozdw 102 16 to to IN cord-020235-stcrozdw 102 17 now now RB cord-020235-stcrozdw 102 18 . . . cord-020235-stcrozdw 103 1 -One -one JJ cord-020235-stcrozdw 103 2 child child NN cord-020235-stcrozdw 103 3 born bear VBN cord-020235-stcrozdw 103 4 to to IN cord-020235-stcrozdw 103 5 an an DT cord-020235-stcrozdw 103 6 HB HB NNP cord-020235-stcrozdw 103 7 e e NN cord-020235-stcrozdw 103 8 antigen antigen NN cord-020235-stcrozdw 103 9 positive positive JJ cord-020235-stcrozdw 103 10 mother mother NN cord-020235-stcrozdw 103 11 was be VBD cord-020235-stcrozdw 103 12 already already RB cord-020235-stcrozdw 103 13 infected infect VBN cord-020235-stcrozdw 103 14 at at IN cord-020235-stcrozdw 103 15 the the DT cord-020235-stcrozdw 103 16 time time NN cord-020235-stcrozdw 103 17 of of IN cord-020235-stcrozdw 103 18 birth birth NN cord-020235-stcrozdw 103 19 . . . cord-020235-stcrozdw 104 1 Another another DT cord-020235-stcrozdw 104 2 child child NN cord-020235-stcrozdw 104 3 born bear VBN cord-020235-stcrozdw 104 4 to to IN cord-020235-stcrozdw 104 5 an an DT cord-020235-stcrozdw 104 6 anti anti JJ cord-020235-stcrozdw 104 7 HB HB NNP cord-020235-stcrozdw 104 8 e e NN cord-020235-stcrozdw 104 9 positive positive JJ cord-020235-stcrozdw 104 10 mother mother NN cord-020235-stcrozdw 104 11 became become VBD cord-020235-stcrozdw 104 12 HBs HBs NNP cord-020235-stcrozdw 104 13 antigen antigen NNP cord-020235-stcrozdw 104 14 positive positive JJ cord-020235-stcrozdw 104 15 at at IN cord-020235-stcrozdw 104 16 the the DT cord-020235-stcrozdw 104 17 age age NN cord-020235-stcrozdw 104 18 of of IN cord-020235-stcrozdw 104 19 4 4 CD cord-020235-stcrozdw 104 20 months month NNS cord-020235-stcrozdw 104 21 . . . cord-020235-stcrozdw 105 1 Unfortunately unfortunately RB cord-020235-stcrozdw 105 2 , , , cord-020235-stcrozdw 105 3 this this DT cord-020235-stcrozdw 105 4 child child NN cord-020235-stcrozdw 105 5 had have VBD cord-020235-stcrozdw 105 6 not not RB cord-020235-stcrozdw 105 7 been be VBN cord-020235-stcrozdw 105 8 treated treat VBN cord-020235-stcrozdw 105 9 with with IN cord-020235-stcrozdw 105 10 HBIG HBIG NNP cord-020235-stcrozdw 105 11 at at IN cord-020235-stcrozdw 105 12 the the DT cord-020235-stcrozdw 105 13 time time NN cord-020235-stcrozdw 105 14 of of IN cord-020235-stcrozdw 105 15 birth birth NN cord-020235-stcrozdw 105 16 . . . cord-020235-stcrozdw 106 1 WILLERS WILLERS NNP cord-020235-stcrozdw 106 2 , , , cord-020235-stcrozdw 106 3 H. H. NNP cord-020235-stcrozdw 106 4 , , , cord-020235-stcrozdw 106 5 PONNATH PONNATH NNP cord-020235-stcrozdw 106 6 , , , cord-020235-stcrozdw 106 7 H. H. NNP cord-020235-stcrozdw 106 8 , , , cord-020235-stcrozdw 106 9 SIPOS SIPOS NNP cord-020235-stcrozdw 106 10 , , , cord-020235-stcrozdw 106 11 S. S. NNP cord-020235-stcrozdw 106 12 , , , cord-020235-stcrozdw 106 13 and and CC cord-020235-stcrozdw 106 14 MOLLER MOLLER NNP cord-020235-stcrozdw 106 15 , , , cord-020235-stcrozdw 106 16 R. R. NNP cord-020235-stcrozdw 106 17 Sera Sera NNP cord-020235-stcrozdw 106 18 of of IN cord-020235-stcrozdw 106 19 5,847 5,847 CD cord-020235-stcrozdw 106 20 pregnant pregnant JJ cord-020235-stcrozdw 106 21 women woman NNS cord-020235-stcrozdw 106 22 living live VBG cord-020235-stcrozdw 106 23 in in IN cord-020235-stcrozdw 106 24 the the DT cord-020235-stcrozdw 106 25 Hannover Hannover NNP cord-020235-stcrozdw 106 26 area area NN cord-020235-stcrozdw 106 27 were be VBD cord-020235-stcrozdw 106 28 investigated investigate VBN cord-020235-stcrozdw 106 29 for for IN cord-020235-stcrozdw 106 30 the the DT cord-020235-stcrozdw 106 31 presence presence NN cord-020235-stcrozdw 106 32 of of IN cord-020235-stcrozdw 106 33 HBsAg hbsag ADD cord-020235-stcrozdw 106 34 . . . cord-020235-stcrozdw 107 1 56 56 CD cord-020235-stcrozdw 107 2 healthy healthy JJ cord-020235-stcrozdw 107 3 HBsAg hbsag CD cord-020235-stcrozdw 107 4 carriers carrier NNS cord-020235-stcrozdw 107 5 were be VBD cord-020235-stcrozdw 107 6 found find VBN cord-020235-stcrozdw 107 7 : : : cord-020235-stcrozdw 107 8 17 17 CD cord-020235-stcrozdw 107 9 ( ( -LRB- cord-020235-stcrozdw 107 10 0.340/0 0.340/0 CD cord-020235-stcrozdw 107 11 ) ) -RRB- cord-020235-stcrozdw 107 12 among among IN cord-020235-stcrozdw 107 13 4,962 4,962 CD cord-020235-stcrozdw 107 14 women woman NNS cord-020235-stcrozdw 107 15 of of IN cord-020235-stcrozdw 107 16 German german JJ cord-020235-stcrozdw 107 17 origin origin NN cord-020235-stcrozdw 107 18 and and CC cord-020235-stcrozdw 107 19 39 39 CD cord-020235-stcrozdw 107 20 ( ( -LRB- cord-020235-stcrozdw 107 21 4.280/0 4.280/0 CD cord-020235-stcrozdw 107 22 ) ) -RRB- cord-020235-stcrozdw 107 23 among among IN cord-020235-stcrozdw 107 24 912 912 CD cord-020235-stcrozdw 107 25 foreign foreign JJ cord-020235-stcrozdw 107 26 - - HYPH cord-020235-stcrozdw 107 27 borne bear VBN cord-020235-stcrozdw 107 28 women woman NNS cord-020235-stcrozdw 107 29 from from IN cord-020235-stcrozdw 107 30 Southern southern JJ cord-020235-stcrozdw 107 31 European european JJ cord-020235-stcrozdw 107 32 and and CC cord-020235-stcrozdw 107 33 non non JJ cord-020235-stcrozdw 107 34 - - JJ cord-020235-stcrozdw 107 35 European european JJ cord-020235-stcrozdw 107 36 countries country NNS cord-020235-stcrozdw 107 37 . . . cord-020235-stcrozdw 108 1 10 10 CD cord-020235-stcrozdw 108 2 out out IN cord-020235-stcrozdw 108 3 of of IN cord-020235-stcrozdw 108 4 the the DT cord-020235-stcrozdw 108 5 56 56 CD cord-020235-stcrozdw 108 6 HBsAg hbsag CD cord-020235-stcrozdw 108 7 carriers carrier NNS cord-020235-stcrozdw 108 8 ( ( -LRB- cord-020235-stcrozdw 108 9 114,962 114,962 CD cord-020235-stcrozdw 108 10 German german JJ cord-020235-stcrozdw 108 11 women woman NNS cord-020235-stcrozdw 108 12 and and CC cord-020235-stcrozdw 108 13 9/912 9/912 CD cord-020235-stcrozdw 108 14 foreign foreign JJ cord-020235-stcrozdw 108 15 - - HYPH cord-020235-stcrozdw 108 16 borne bear VBN cord-020235-stcrozdw 108 17 women woman NNS cord-020235-stcrozdw 108 18 ) ) -RRB- cord-020235-stcrozdw 108 19 were be VBD cord-020235-stcrozdw 108 20 recognized recognize VBN cord-020235-stcrozdw 108 21 to to TO cord-020235-stcrozdw 108 22 be be VB cord-020235-stcrozdw 108 23 HBeAg hbeag CD cord-020235-stcrozdw 108 24 - - HYPH cord-020235-stcrozdw 108 25 positive positive JJ cord-020235-stcrozdw 108 26 . . . cord-020235-stcrozdw 109 1 -The -The : cord-020235-stcrozdw 109 2 risk risk NN cord-020235-stcrozdw 109 3 of of IN cord-020235-stcrozdw 109 4 perinatal perinatal JJ cord-020235-stcrozdw 109 5 transmission transmission NN cord-020235-stcrozdw 109 6 of of IN cord-020235-stcrozdw 109 7 hepatitis hepatitis NN cord-020235-stcrozdw 109 8 B B NNP cord-020235-stcrozdw 109 9 virus virus NN cord-020235-stcrozdw 109 10 in in IN cord-020235-stcrozdw 109 11 infants infant NNS cord-020235-stcrozdw 109 12 of of IN cord-020235-stcrozdw 109 13 HBeAg hbeag CD cord-020235-stcrozdw 109 14 - - HYPH cord-020235-stcrozdw 109 15 positive positive JJ cord-020235-stcrozdw 109 16 mothers mother NNS cord-020235-stcrozdw 109 17 is be VBZ cord-020235-stcrozdw 109 18 suggested suggest VBN cord-020235-stcrozdw 109 19 to to TO cord-020235-stcrozdw 109 20 be be VB cord-020235-stcrozdw 109 21 90 90 CD cord-020235-stcrozdw 109 22 % % NN cord-020235-stcrozdw 109 23 and and CC cord-020235-stcrozdw 109 24 of of IN cord-020235-stcrozdw 109 25 HBeAg hbeag CD cord-020235-stcrozdw 109 26 - - HYPH cord-020235-stcrozdw 109 27 negative negative JJ cord-020235-stcrozdw 109 28 mothers mother NNS cord-020235-stcrozdw 109 29 12 12 CD cord-020235-stcrozdw 109 30 0/0 0/0 CD cord-020235-stcrozdw 109 31 . . . cord-020235-stcrozdw 110 1 -Thus -Thus : cord-020235-stcrozdw 111 1 in in IN cord-020235-stcrozdw 111 2 the the DT cord-020235-stcrozdw 111 3 Hannover Hannover NNP cord-020235-stcrozdw 111 4 area area NN cord-020235-stcrozdw 111 5 6 6 CD cord-020235-stcrozdw 111 6 out out IN cord-020235-stcrozdw 111 7 of of IN cord-020235-stcrozdw 111 8 10,000 10,000 CD cord-020235-stcrozdw 111 9 infants infant NNS cord-020235-stcrozdw 111 10 born bear VBN cord-020235-stcrozdw 111 11 to to IN cord-020235-stcrozdw 111 12 German german JJ cord-020235-stcrozdw 111 13 mothers mother NNS cord-020235-stcrozdw 111 14 and and CC cord-020235-stcrozdw 111 15 129 129 CD cord-020235-stcrozdw 111 16 out out IN cord-020235-stcrozdw 111 17 of of IN cord-020235-stcrozdw 111 18 10,000 10,000 CD cord-020235-stcrozdw 111 19 infants infant NNS cord-020235-stcrozdw 111 20 born bear VBN cord-020235-stcrozdw 111 21 ro ro NNP cord-020235-stcrozdw 111 22 foreign foreign JJ cord-020235-stcrozdw 111 23 mothers mother NNS cord-020235-stcrozdw 111 24 become become VBP cord-020235-stcrozdw 111 25 HBsAg HBsAg NNP cord-020235-stcrozdw 111 26 carriers carrier NNS cord-020235-stcrozdw 111 27 due due JJ cord-020235-stcrozdw 111 28 to to IN cord-020235-stcrozdw 111 29 perinatal perinatal JJ cord-020235-stcrozdw 111 30 hepatitis hepatitis NN cord-020235-stcrozdw 111 31 B B NNP cord-020235-stcrozdw 111 32 virus virus NN cord-020235-stcrozdw 111 33 - - HYPH cord-020235-stcrozdw 111 34 infection infection NN cord-020235-stcrozdw 111 35 . . . cord-020235-stcrozdw 112 1 Max Max NNP cord-020235-stcrozdw 112 2 von von NNP cord-020235-stcrozdw 112 3 Pettenkofer Pettenkofer NNP cord-020235-stcrozdw 112 4 Insr Insr NNP cord-020235-stcrozdw 112 5 . . . cord-020235-stcrozdw 112 6 , , , cord-020235-stcrozdw 112 7 Univ Univ NNP cord-020235-stcrozdw 112 8 . . . cord-020235-stcrozdw 113 1 D-8000 D-8000 NNP cord-020235-stcrozdw 114 1 Munich Munich NNP cord-020235-stcrozdw 114 2 2 2 CD cord-020235-stcrozdw 114 3 A a DT cord-020235-stcrozdw 114 4 radioimmunoassay radioimmunoassay NN cord-020235-stcrozdw 114 5 for for IN cord-020235-stcrozdw 114 6 anti anti JJ cord-020235-stcrozdw 114 7 - - JJ cord-020235-stcrozdw 114 8 HBc hbc JJ cord-020235-stcrozdw 114 9 IgM IgM NNP cord-020235-stcrozdw 114 10 using use VBG cord-020235-stcrozdw 114 11 higher high JJR cord-020235-stcrozdw 114 12 concentration concentration NN cord-020235-stcrozdw 114 13 for for IN cord-020235-stcrozdw 114 14 the the DT cord-020235-stcrozdw 114 15 dilution dilution NN cord-020235-stcrozdw 114 16 of of IN cord-020235-stcrozdw 114 17 serum serum NN cord-020235-stcrozdw 114 18 ( ( -LRB- cord-020235-stcrozdw 114 19 5 5 CD cord-020235-stcrozdw 114 20 mg mg NNP cord-020235-stcrozdw 114 21 / / SYM cord-020235-stcrozdw 114 22 ml ml NN cord-020235-stcrozdw 114 23 ) ) -RRB- cord-020235-stcrozdw 115 1 and and CC cord-020235-stcrozdw 115 2 HBcAg hbcag CD cord-020235-stcrozdw 115 3 ( ( -LRB- cord-020235-stcrozdw 115 4 10 10 CD cord-020235-stcrozdw 115 5 mg mg NNP cord-020235-stcrozdw 115 6 / / SYM cord-020235-stcrozdw 115 7 ml ml NN cord-020235-stcrozdw 115 8 ) ) -RRB- cord-020235-stcrozdw 115 9 was be VBD cord-020235-stcrozdw 115 10 compared compare VBN cord-020235-stcrozdw 115 11 with with IN cord-020235-stcrozdw 115 12 an an DT cord-020235-stcrozdw 115 13 ELISA ELISA NNP cord-020235-stcrozdw 115 14 test test NN cord-020235-stcrozdw 115 15 ] ] -RRB- cord-020235-stcrozdw 115 16 . . . cord-020235-stcrozdw 116 1 din din NNP cord-020235-stcrozdw 116 2 . . . cord-020235-stcrozdw 117 1 Microb Microb NNP cord-020235-stcrozdw 117 2 iol iol NNP cord-020235-stcrozdw 117 3 . . . cord-020235-stcrozdw 118 1 13 13 CD cord-020235-stcrozdw 118 2 ( ( -LRB- cord-020235-stcrozdw 118 3 1981 1981 CD cord-020235-stcrozdw 118 4 ) ) -RRB- cord-020235-stcrozdw 118 5 , , , cord-020235-stcrozdw 118 6 618 618 CD cord-020235-stcrozdw 118 7 . . . cord-020235-stcrozdw 119 1 Onl Onl NNP cord-020235-stcrozdw 119 2 y y NNP cord-020235-stcrozdw 119 3 10 10 CD cord-020235-stcrozdw 119 4 of of IN cord-020235-stcrozdw 119 5 157 157 CD cord-020235-stcrozdw 119 6 ( ( -LRB- cord-020235-stcrozdw 119 7 6 6 CD cord-020235-stcrozdw 119 8 0 0 CD cord-020235-stcrozdw 119 9 /0 /0 . cord-020235-stcrozdw 119 10 ) ) -RRB- cord-020235-stcrozdw 120 1 HBsAg hbsag ADD cord-020235-stcrozdw 120 2 positive positive JJ cord-020235-stcrozdw 120 3 blood blood NN cord-020235-stcrozdw 120 4 don don NNP cord-020235-stcrozdw 120 5 ors or NNS cord-020235-stcrozdw 120 6 were be VBD cord-020235-stcrozdw 120 7 positive positive JJ cord-020235-stcrozdw 120 8 ( ( -LRB- cord-020235-stcrozdw 120 9 40 40 CD cord-020235-stcrozdw 120 10 in in IN cord-020235-stcrozdw 120 11 ELISA ELISA NNP cord-020235-stcrozdw 120 12 ) ) -RRB- cord-020235-stcrozdw 120 13 and and CC cord-020235-stcrozdw 121 1 no no DT cord-020235-stcrozdw 121 2 correl correl NN cord-020235-stcrozdw 121 3 ation ation NN cord-020235-stcrozdw 121 4 with with IN cord-020235-stcrozdw 121 5 the the DT cord-020235-stcrozdw 121 6 total total JJ cord-020235-stcrozdw 121 7 anti anti JJ cord-020235-stcrozdw 121 8 -HBc -hbc NN cord-020235-stcrozdw 121 9 titer titer NN cord-020235-stcrozdw 121 10 could could MD cord-020235-stcrozdw 121 11 be be VB cord-020235-stcrozdw 121 12 found find VBN cord-020235-stcrozdw 121 13 . . . cord-020235-stcrozdw 122 1 After after IN cord-020235-stcrozdw 122 2 fraction fraction NN cord-020235-stcrozdw 122 3 ation ation NN cord-020235-stcrozdw 122 4 of of IN cord-020235-stcrozdw 122 5 a a DT cord-020235-stcrozdw 122 6 serum serum NN cord-020235-stcrozdw 122 7 with with IN cord-020235-stcrozdw 122 8 discrepant discrepant JJ cord-020235-stcrozdw 122 9 results result NNS cord-020235-stcrozdw 122 10 a a DT cord-020235-stcrozdw 122 11 positi positi NNP cord-020235-stcrozdw 122 12 ve ve VBN cord-020235-stcrozdw 122 13 result result NN cord-020235-stcrozdw 122 14 was be VBD cord-020235-stcrozdw 122 15 found find VBN cord-020235-stcrozdw 122 16 in in IN cord-020235-stcrozdw 122 17 the the DT cord-020235-stcrozdw 122 18 ELISA ELISA NNP cord-020235-stcrozdw 122 19 only only RB cord-020235-stcrozdw 122 20 in in IN cord-020235-stcrozdw 122 21 the the DT cord-020235-stcrozdw 122 22 IgG igg NN cord-020235-stcrozdw 122 23 fractions fraction NNS cord-020235-stcrozdw 122 24 . . . cord-020235-stcrozdw 123 1 In in IN cord-020235-stcrozdw 123 2 a a DT cord-020235-stcrozdw 123 3 collaborative collaborative JJ cord-020235-stcrozdw 123 4 stu stu NNP cord-020235-stcrozdw 123 5 dy dy NNP cord-020235-stcrozdw 123 6 with with IN cord-020235-stcrozdw 123 7 A A NNP cord-020235-stcrozdw 123 8 / / SYM cord-020235-stcrozdw 123 9 torfer torfer NN cord-020235-stcrozdw 123 10 et et NNP cord-020235-stcrozdw 123 11 al al NNP cord-020235-stcrozdw 123 12 . . . cord-020235-stcrozdw 124 1 ( ( -LRB- cord-020235-stcrozdw 124 2 presented present VBN cord-020235-stcrozdw 124 3 also also RB cord-020235-stcrozdw 124 4 at at IN cord-020235-stcrozdw 124 5 Lisbo Lisbo NNP cord-020235-stcrozdw 124 6 n n NNP cord-020235-stcrozdw 124 7 , , , cord-020235-stcrozdw 124 8 EASL EASL NNP cord-020235-stcrozdw 124 9 1981 1981 CD cord-020235-stcrozdw 124 10 ( ( -LRB- cord-020235-stcrozdw 124 11 1981 1981 CD cord-020235-stcrozdw 124 12 ) ) -RRB- cord-020235-stcrozdw 124 13 , , , cord-020235-stcrozdw 124 14 who who WP cord-020235-stcrozdw 124 15 show show VBP cord-020235-stcrozdw 124 16 ed ed NNP cord-020235-stcrozdw 124 17 a a DT cord-020235-stcrozdw 124 18 10 10 CD cord-020235-stcrozdw 124 19 6 6 CD cord-020235-stcrozdw 124 20 fold fold JJ cord-020235-stcrozdw 124 21 reduction reduction NN cord-020235-stcrozdw 124 22 in in IN cord-020235-stcrozdw 124 23 hepatitis hepatitis NN cord-020235-stcrozdw 124 24 B B NNP cord-020235-stcrozdw 124 25 titer titer NN cord-020235-stcrozdw 124 26 by by IN cord-020235-stcrozdw 124 27 means mean NNS cord-020235-stcrozdw 124 28 of of IN cord-020235-stcrozdw 124 29 ! ! . cord-020235-stcrozdw 125 1 i i PRP cord-020235-stcrozdw 125 2 - - HYPH cord-020235-stcrozdw 125 3 PLlUV PLlUV NNP cord-020235-stcrozdw 125 4 treatme treatme NNP cord-020235-stcrozdw 125 5 nt nt RB cord-020235-stcrozdw 125 6 . . . cord-020235-stcrozdw 126 1 The the DT cord-020235-stcrozdw 126 2 effectiveness effectiveness NN cord-020235-stcrozdw 126 3 of of IN cord-020235-stcrozdw 126 4 the the DT cord-020235-stcrozdw 126 5 cold cold JJ cord-020235-stcrozdw 126 6 sterilization sterilization NN cord-020235-stcrozdw 126 7 procedure procedure NN cord-020235-stcrozdw 126 8 as as IN cord-020235-stcrozdw 126 9 regards regard VBZ cord-020235-stcrozdw 126 10 reducing reduce VBG cord-020235-stcrozdw 126 11 virus virus NN cord-020235-stcrozdw 126 12 infectivity infectivity NN cord-020235-stcrozdw 126 13 is be VBZ cord-020235-stcrozdw 126 14 considera considera JJ cord-020235-stcrozdw 126 15 bly bly RB cord-020235-stcrozdw 126 16 greater great JJR cord-020235-stcrozdw 126 17 than than IN cord-020235-stcrozdw 126 18 that that DT cord-020235-stcrozdw 126 19 of of IN cord-020235-stcrozdw 126 20 pasteurization pasteurization NN cord-020235-stcrozdw 126 21 ( ( -LRB- cord-020235-stcrozdw 126 22 10 10 CD cord-020235-stcrozdw 126 23 h h NN cord-020235-stcrozdw 126 24 60 60 CD cord-020235-stcrozdw 126 25 DC DC NNP cord-020235-stcrozdw 126 26 ) ) -RRB- cord-020235-stcrozdw 126 27 for for IN cord-020235-stcrozdw 126 28 which which WDT cord-020235-stcrozdw 126 29 Shikata Shikata NNP cord-020235-stcrozdw 126 30 et et NNP cord-020235-stcrozdw 126 31 al al NNP cord-020235-stcrozdw 126 32 . . . cord-020235-stcrozdw 127 1 ( ( -LRB- cord-020235-stcrozdw 127 2 1977 1977 CD cord-020235-stcrozdw 127 3 ) ) -RRB- cord-020235-stcrozdw 128 1 sho sho UH cord-020235-stcrozdw 128 2 we -PRON- PRP cord-020235-stcrozdw 129 1 d d NNP cord-020235-stcrozdw 129 2 a a DT cord-020235-stcrozdw 129 3 10 10 CD cord-020235-stcrozdw 129 4 4 4 CD cord-020235-stcrozdw 129 5 fold fold JJ cord-020235-stcrozdw 129 6 reduction reduction NN cord-020235-stcrozdw 129 7 of of IN cord-020235-stcrozdw 129 8 hep hep NN cord-020235-stcrozdw 129 9 atitis atitis NNP cord-020235-stcrozdw 129 10 B B NNP cord-020235-stcrozdw 129 11 virus virus NN cord-020235-stcrozdw 129 12 infectivity infectivity NN cord-020235-stcrozdw 129 13 . . . cord-020235-stcrozdw 130 1 It -PRON- PRP cord-020235-stcrozdw 130 2 has have VBZ cord-020235-stcrozdw 130 3 also also RB cord-020235-stcrozdw 130 4 been be VBN cord-020235-stcrozdw 130 5 found find VBN cord-020235-stcrozdw 130 6 that that IN cord-020235-stcrozdw 130 7 factor factor NN cord-020235-stcrozdw 130 8 IX IX NNP cord-020235-stcrozdw 130 9 conce conce NNP cord-020235-stcrozdw 130 10 ntrate ntrate NNP cord-020235-stcrozdw 130 11 and and CC cord-020235-stcrozdw 130 12 stab stab VB cord-020235-stcrozdw 130 13 ilized ilized JJ cord-020235-stcrozdw 130 14 serum serum NN cord-020235-stcrozdw 130 15 ( ( -LRB- cord-020235-stcrozdw 131 1 Biseko Biseko NNP cord-020235-stcrozdw 131 2 ® ® LS cord-020235-stcrozdw 131 3 ) ) -RRB- cord-020235-stcrozdw 131 4 der der NNP cord-020235-stcrozdw 131 5 ived ive VBD cord-020235-stcrozdw 131 6 from from IN cord-020235-stcrozdw 131 7 pooled pool VBN cord-020235-stcrozdw 131 8 . . . cord-020235-stcrozdw 132 1 cold cold JJ cord-020235-stcrozdw 132 2 - - HYPH cord-020235-stcrozdw 132 3 sterilization sterilization NN cord-020235-stcrozdw 132 4 hu hu NNP cord-020235-stcrozdw 132 5 man man NN cord-020235-stcrozdw 132 6 plasma plasma NN cord-020235-stcrozdw 132 7 transmitted transmit VBN cord-020235-stcrozdw 133 1 neither neither DT cord-020235-stcrozdw 133 2 hepatitis hepatitis NN cord-020235-stcrozdw 133 3 B B NNP cord-020235-stcrozdw 133 4 nor nor CC cord-020235-stcrozdw 133 5 hepatit hepatit NNP cord-020235-stcrozdw 133 6 is be VBZ cord-020235-stcrozdw 133 7 no no DT cord-020235-stcrozdw 133 8 n n NN cord-020235-stcrozdw 133 9 - - HYPH cord-020235-stcrozdw 133 10 A a NN cord-020235-stcrozdw 133 11 , , , cord-020235-stcrozdw 133 12 non non NN cord-020235-stcrozdw 133 13 - - NN cord-020235-stcrozdw 133 14 B b NN cord-020235-stcrozdw 133 15 in in IN cord-020235-stcrozdw 133 16 chimpa chimpa NNP cord-020235-stcrozdw 133 17 nzees nzee NNS cord-020235-stcrozdw 133 18 . . . cord-020235-stcrozdw 134 1 Max Max NNP cord-020235-stcrozdw 134 2 von von NNP cord-020235-stcrozdw 134 3 Pettenk Pettenk NNP cord-020235-stcrozdw 134 4 ofer ofer NNP cord-020235-stcrozdw 134 5 - - HYPH cord-020235-stcrozdw 134 6 Insr Insr NNP cord-020235-stcrozdw 134 7 . . . cord-020235-stcrozdw 135 1 , , , cord-020235-stcrozdw 135 2 0 0 CD cord-020235-stcrozdw 136 1 -8000 -8000 NNP cord-020235-stcrozdw 136 2 Miinchen Miinchen NNP cord-020235-stcrozdw 136 3 2 2 CD cord-020235-stcrozdw 136 4 Comparison comparison NN cord-020235-stcrozdw 136 5 of of IN cord-020235-stcrozdw 136 6 Different Different NNP cord-020235-stcrozdw 136 7 Evaluation Evaluation NNP cord-020235-stcrozdw 136 8 Systems Systems NNPS cord-020235-stcrozdw 136 9 for for IN cord-020235-stcrozdw 136 10 Determination determination NN cord-020235-stcrozdw 136 11 of of IN cord-020235-stcrozdw 136 12 Viral Viral NNP cord-020235-stcrozdw 136 13 Antibodie Antibodie NNP cord-020235-stcrozdw 136 14 s s POS cord-020235-stcrozdw 136 15 of of IN cord-020235-stcrozdw 136 16 the the DT cord-020235-stcrozdw 136 17 IgG IgG NNP cord-020235-stcrozdw 136 18 and and CC cord-020235-stcrozdw 136 19 IgM IgM NNP cord-020235-stcrozdw 136 20 Class Class NNP cord-020235-stcrozdw 136 21 in in IN cord-020235-stcrozdw 136 22 the the DT cord-020235-stcrozdw 136 23 Enzymeimmunoassay Enzymeimmunoassay NNP cord-020235-stcrozdw 136 24 R r NN cord-020235-stcrozdw 136 25 O o NN cord-020235-stcrozdw 136 26 G g NN cord-020235-stcrozdw 136 27 G g NN cord-020235-stcrozdw 136 28 ENDORF ENDORF NNP cord-020235-stcrozdw 136 29 , , , cord-020235-stcrozdw 136 30 M. M. NNP cord-020235-stcrozdw 136 31 , , , cord-020235-stcrozdw 136 32 ZACHOVAL ZACHOVAL NNP cord-020235-stcrozdw 136 33 , , , cord-020235-stcrozdw 136 34 R R NNP cord-020235-stcrozdw 136 35 . . NNP cord-020235-stcrozdw 136 36 , , , cord-020235-stcrozdw 136 37 ZOULEK ZOULEK NNP cord-020235-stcrozdw 136 38 , , , cord-020235-stcrozdw 136 39 G. G. NNP cord-020235-stcrozdw 136 40 , , , cord-020235-stcrozdw 136 41 a a DT cord-020235-stcrozdw 136 42 nd nd NNP cord-020235-stcrozdw 136 43 DEINHAROT DEINHAROT NNP cord-020235-stcrozdw 136 44 , , , cord-020235-stcrozdw 136 45 F. F. NNP cord-020235-stcrozdw 136 46 T t NN cord-020235-stcrozdw 137 1 he -PRON- PRP cord-020235-stcrozdw 137 2 enzymeimmunoassays enzymeimmunoassays RB cord-020235-stcrozdw 137 3 used use VBD cord-020235-stcrozdw 137 4 to to TO cord-020235-stcrozdw 137 5 demonstrate demonstrate VB cord-020235-stcrozdw 137 6 antibodies antibody NNS cord-020235-stcrozdw 137 7 of of IN cord-020235-stcrozdw 137 8 the the DT cord-020235-stcrozdw 137 9 IgG IgG NNP cord-020235-stcrozdw 137 10 and and CC cord-020235-stcrozdw 137 11 IgM IgM NNP cord-020235-stcrozdw 137 12 class class NNP cord-020235-stcrozdw 137 13 against against IN cord-020235-stcrozdw 137 14 viral viral JJ cord-020235-stcrozdw 137 15 antigens antigen NNS cord-020235-stcrozdw 137 16 reveal reveal VBP cord-020235-stcrozdw 137 17 a a DT cord-020235-stcrozdw 137 18 high high JJ cord-020235-stcrozdw 137 19 sensitivity sensitivity NN cord-020235-stcrozdw 137 20 . . . cord-020235-stcrozdw 138 1 At at IN cord-020235-stcrozdw 138 2 onset onset NN cord-020235-stcrozdw 138 3 of of IN cord-020235-stcrozdw 138 4 acute acute JJ cord-020235-stcrozdw 138 5 viral viral JJ cord-020235-stcrozdw 138 6 infections infection NNS cord-020235-stcrozdw 138 7 IgM IgM NNP cord-020235-stcrozdw 138 8 antibodies antibody NNS cord-020235-stcrozdw 138 9 can can MD cord-020235-stcrozdw 138 10 be be VB cord-020235-stcrozdw 138 11 demonstrated demonstrate VBN cord-020235-stcrozdw 138 12 up up RP cord-020235-stcrozdw 138 13 to to IN cord-020235-stcrozdw 138 14 serum serum NN cord-020235-stcrozdw 138 15 dilutions dilution NNS cord-020235-stcrozdw 138 16 of of IN cord-020235-stcrozdw 138 17 10 10 CD cord-020235-stcrozdw 138 18 - - SYM cord-020235-stcrozdw 138 19 7 7 CD cord-020235-stcrozdw 138 20 • • NN cord-020235-stcrozdw 139 1 Due due IN cord-020235-stcrozdw 139 2 to to IN cord-020235-stcrozdw 139 3 th th XX cord-020235-stcrozdw 139 4 is be VBZ cord-020235-stcrozdw 139 5 high high JJ cord-020235-stcrozdw 139 6 sensitivity sensitivity NN cord-020235-stcrozdw 139 7 , , , cord-020235-stcrozdw 139 8 the the DT cord-020235-stcrozdw 139 9 determin determin NN cord-020235-stcrozdw 139 10 ation ation NN cord-020235-stcrozdw 139 11 of of IN cord-020235-stcrozdw 139 12 antibody antibody NN cord-020235-stcrozdw 139 13 tite tite NNP cord-020235-stcrozdw 139 14 rs rs NN cord-020235-stcrozdw 139 15 is be VBZ cord-020235-stcrozdw 139 16 not not RB cord-020235-stcrozdw 139 17 accurate accurate JJ cord-020235-stcrozdw 139 18 and and CC cord-020235-stcrozdw 139 19 reproducible reproducible JJ cord-020235-stcrozdw 139 20 , , , cord-020235-stcrozdw 139 21 because because IN cord-020235-stcrozdw 139 22 titer titer NN cord-020235-stcrozdw 139 23 end end NN cord-020235-stcrozdw 139 24 points point NNS cord-020235-stcrozdw 139 25 are be VBP cord-020235-stcrozdw 139 26 determ determ NNP cord-020235-stcrozdw 139 27 ined ined NNP cord-020235-stcrozdw 139 28 as as IN cord-020235-stcrozdw 139 29 that that DT cord-020235-stcrozdw 139 30 dilution dilution NN cord-020235-stcrozdw 139 31 of of IN cord-020235-stcrozdw 139 32 sera sera NNP cord-020235-stcrozdw 139 33 giving give VBG cord-020235-stcrozdw 139 34 an an DT cord-020235-stcrozdw 139 35 0.0 0.0 CD cord-020235-stcrozdw 139 36 . . . cord-020235-stcrozdw 140 1 sample sample NN cord-020235-stcrozdw 140 2 / / SYM cord-020235-stcrozdw 140 3 O o UH cord-020235-stcrozdw 140 4 .O. .O. NFP cord-020235-stcrozdw 140 5 negative negative JJ cord-020235-stcrozdw 140 6 control control NN cord-020235-stcrozdw 140 7 equal equal JJ cord-020235-stcrozdw 140 8 or or CC cord-020235-stcrozdw 140 9 greater great JJR cord-020235-stcrozdw 140 10 than than IN cord-020235-stcrozdw 140 11 2.1 2.1 CD cord-020235-stcrozdw 140 12 . . . cord-020235-stcrozdw 141 1 -For -For . cord-020235-stcrozdw 142 1 the the DT cord-020235-stcrozdw 142 2 dete dete NNP cord-020235-stcrozdw 142 3 rmination rmination NN cord-020235-stcrozdw 142 4 of of IN cord-020235-stcrozdw 142 5 antibody antibody NN cord-020235-stcrozdw 142 6 con con FW cord-020235-stcrozdw 142 7 centr centr NN cord-020235-stcrozdw 142 8 ations ation NNS cord-020235-stcrozdw 143 1 an an DT cord-020235-stcrozdw 143 2 evaluation evaluation NN cord-020235-stcrozdw 143 3 method method NN cord-020235-stcrozdw 143 4 is be VBZ cord-020235-stcrozdw 143 5 proposed propose VBN cord-020235-stcrozdw 143 6 which which WDT cord-020235-stcrozdw 143 7 correlates correlate VBZ cord-020235-stcrozdw 143 8 , , , cord-020235-stcrozdw 144 1 the the DT cord-020235-stcrozdw 144 2 measured measure VBN cord-020235-stcrozdw 144 3 0 0 CD cord-020235-stcrozdw 144 4 .0 .0 NFP cord-020235-stcrozdw 144 5 . . . cord-020235-stcrozdw 145 1 of of IN cord-020235-stcrozdw 145 2 sera sera NNP cord-020235-stcrozdw 145 3 at at IN cord-020235-stcrozdw 145 4 one one CD cord-020235-stcrozdw 145 5 dilut dilut NNP cord-020235-stcrozdw 145 6 ion ion NN cord-020235-stcrozdw 145 7 step step NN cord-020235-stcrozdw 145 8 to to IN cord-020235-stcrozdw 145 9 the the DT cord-020235-stcrozdw 145 10 0 0 CD cord-020235-stcrozdw 145 11 .0 .0 NFP cord-020235-stcrozdw 145 12 . . . cord-020235-stcrozdw 146 1 of of IN cord-020235-stcrozdw 146 2 a a DT cord-020235-stcrozdw 146 3 reference reference NN cord-020235-stcrozdw 146 4 serum serum NN cord-020235-stcrozdw 146 5 which which WDT cord-020235-stcrozdw 146 6 is be VBZ cord-020235-stcrozdw 146 7 defined define VBN cord-020235-stcrozdw 146 8 arbitrarily arbitrarily RB cord-020235-stcrozdw 146 9 to to TO cord-020235-stcrozdw 146 10 contain contain VB cord-020235-stcrozdw 146 11 100 100 CD cord-020235-stcrozdw 146 12 anti anti JJ cord-020235-stcrozdw 146 13 body body NN cord-020235-stcrozdw 146 14 units unit NNS cord-020235-stcrozdw 146 15 . . . cord-020235-stcrozdw 147 1 Using use VBG cord-020235-stcrozdw 147 2 an an DT cord-020235-stcrozdw 147 3 ELISA ELISA NNP cord-020235-stcrozdw 147 4 for for IN cord-020235-stcrozdw 147 5 detection detection NN cord-020235-stcrozdw 147 6 of of IN cord-020235-stcrozdw 147 7 antibodies antibody NNS cord-020235-stcrozdw 147 8 to to IN cord-020235-stcrozdw 147 9 adenovirus adenovirus NN cord-020235-stcrozdw 147 10 , , , cord-020235-stcrozdw 147 11 a a DT cord-020235-stcrozdw 147 12 significant significant JJ cord-020235-stcrozdw 147 13 increase increase NN cord-020235-stcrozdw 147 14 in in IN cord-020235-stcrozdw 147 15 antibod antibod NNP cord-020235-stcrozdw 147 16 y y NNP cord-020235-stcrozdw 147 17 units unit NNS cord-020235-stcrozdw 147 18 of of IN cord-020235-stcrozdw 147 19 acute acute JJ cord-020235-stcrozdw 147 20 phase phase NN cord-020235-stcrozdw 147 21 sera sera NNP cord-020235-stcrozdw 147 22 over over IN cord-020235-stcrozdw 147 23 that that DT cord-020235-stcrozdw 147 24 of of IN cord-020235-stcrozdw 147 25 convalescent convalescent JJ cord-020235-stcrozdw 147 26 pha pha FW cord-020235-stcrozdw 147 27 se se FW cord-020235-stcrozdw 147 28 sera sera NNP cord-020235-stcrozdw 147 29 is be VBZ cord-020235-stcrozdw 147 30 observed observe VBN cord-020235-stcrozdw 147 31 . . . cord-020235-stcrozdw 148 1 Low low JJ cord-020235-stcrozdw 148 2 day day NN cord-020235-stcrozdw 148 3 to to IN cord-020235-stcrozdw 148 4 da da NNP cord-020235-stcrozdw 148 5 y y NNP cord-020235-stcrozdw 148 6 varia varia FW cord-020235-stcrozdw 148 7 tions tion NNS cord-020235-stcrozdw 148 8 are be VBP cord-020235-stcrozdw 148 9 seen see VBN cord-020235-stcrozdw 148 10 in in IN cord-020235-stcrozdw 148 11 tests test NNS cord-020235-stcrozdw 148 12 car car NN cord-020235-stcrozdw 148 13 ried rie VBD cord-020235-stcrozdw 148 14 out out RP cord-020235-stcrozdw 148 15 on on IN cord-020235-stcrozdw 148 16 different different JJ cord-020235-stcrozdw 148 17 days day NNS cord-020235-stcrozdw 148 18 . . . cord-020235-stcrozdw 149 1 In in IN cord-020235-stcrozdw 149 2 an an DT cord-020235-stcrozdw 149 3 ELISA ELISA NNP cord-020235-stcrozdw 149 4 which which WDT cord-020235-stcrozdw 149 5 is be VBZ cord-020235-stcrozdw 149 6 designed design VBN cord-020235-stcrozdw 149 7 to to TO cord-020235-stcrozdw 149 8 detect detect VB cord-020235-stcrozdw 149 9 anti anti JJ cord-020235-stcrozdw 149 10 bodies body NNS cord-020235-stcrozdw 149 11 to to TO cord-020235-stcrozdw 149 12 tick tick VB cord-020235-stcrozdw 149 13 - - HYPH cord-020235-stcrozdw 149 14 born bear VBN cord-020235-stcrozdw 149 15 e e NN cord-020235-stcrozdw 149 16 encephalitis encephalitis NN cord-020235-stcrozdw 149 17 virus virus NN cord-020235-stcrozdw 149 18 of of IN cord-020235-stcrozdw 149 19 th th XX cord-020235-stcrozdw 149 20 e e NN cord-020235-stcrozdw 149 21 IgM IgM NNP cord-020235-stcrozdw 149 22 class class NNP cord-020235-stcrozdw 149 23 , , , cord-020235-stcrozdw 149 24 the the DT cord-020235-stcrozdw 149 25 day day NN cord-020235-stcrozdw 149 26 to to IN cord-020235-stcrozdw 149 27 day day NN cord-020235-stcrozdw 149 28 variatio variatio NNP cord-020235-stcrozdw 149 29 n n NNP cord-020235-stcrozdw 149 30 using use VBG cord-020235-stcrozdw 149 31 antibody antibody NN cord-020235-stcrozdw 149 32 units unit NNS cord-020235-stcrozdw 149 33 was be VBD cord-020235-stcrozdw 149 34 significantly significantly RB cord-020235-stcrozdw 149 35 lower low JJR cord-020235-stcrozdw 149 36 th th XX cord-020235-stcrozdw 149 37 an an DT cord-020235-stcrozdw 149 38 using use VBG cord-020235-stcrozdw 149 39 PIN pin NN cord-020235-stcrozdw 149 40 ratios ratio NNS cord-020235-stcrozdw 149 41 . . . cord-020235-stcrozdw 150 1 Inst Inst NNP cord-020235-stcrozdw 150 2 . . . cord-020235-stcrozdw 151 1 f. f. NNP cord-020235-stcrozdw 151 2 Virolog Virolog NNP cord-020235-stcrozdw 152 1 ie ie NNP cord-020235-stcrozdw 153 1 , , , cord-020235-stcrozdw 153 2 jusrus jusrus NNP cord-020235-stcrozdw 153 3 - - HYPH cord-020235-stcrozdw 153 4 Liebi Liebi NNP cord-020235-stcrozdw 153 5 g g NNP cord-020235-stcrozdw 153 6 - - HYPH cord-020235-stcrozdw 153 7 Un Un NNP cord-020235-stcrozdw 153 8 iv iv NNP cord-020235-stcrozdw 153 9 . . . cord-020235-stcrozdw 154 1 , , , cord-020235-stcrozdw 154 2 0 0 CD cord-020235-stcrozdw 154 3 -6300 -6300 . cord-020235-stcrozdw 154 4 GieBen GieBen NNP cord-020235-stcrozdw 155 1 ; ; : cord-020235-stcrozdw 155 2 Max Max NNP cord-020235-stcrozdw 155 3 - - HYPH cord-020235-stcrozdw 155 4 Planck Planck NNP cord-020235-stcrozdw 155 5 - - HYPH cord-020235-stcrozdw 155 6 Insr Insr NNP cord-020235-stcrozdw 155 7 , , , cord-020235-stcrozdw 155 8 f. f. NNP cord-020235-stcrozdw 155 9 M M NNP cord-020235-stcrozdw 155 10 olekulare olekulare NN cord-020235-stcrozdw 155 11 Genet Genet NNP cord-020235-stcrozdw 155 12 ik ik NNP cord-020235-stcrozdw 155 13 , , , cord-020235-stcrozdw 155 14 D D NNP cord-020235-stcrozdw 155 15 -lOoo -lOoo : cord-020235-stcrozdw 155 16 Berlin Berlin NNP cord-020235-stcrozdw 155 17 Structure Structure NNP cord-020235-stcrozdw 155 18 and and CC cord-020235-stcrozdw 155 19 Function Function NNP cord-020235-stcrozdw 155 20 of of IN cord-020235-stcrozdw 155 21 the the DT cord-020235-stcrozdw 155 22 Core Core NNP cord-020235-stcrozdw 155 23 Protein Protein NNP cord-020235-stcrozdw 155 24 of of IN cord-020235-stcrozdw 155 25 Alphaviruses Alphaviruses NNP cord-020235-stcrozdw 155 26 BOEGE BOEGE NNP cord-020235-stcrozdw 155 27 , , , cord-020235-stcrozdw 155 28 ULRIKE ULRIKE NNP cord-020235-stcrozdw 155 29 and and CC cord-020235-stcrozdw 155 30 WITT WITT NNP cord-020235-stcrozdw 155 31 MAN MAN NNP cord-020235-stcrozdw 155 32 N N NNP cord-020235-stcrozdw 155 33 - - HYPH cord-020235-stcrozdw 155 34 LIEBOLD LIEBOLD NNP cord-020235-stcrozdw 155 35 , , , cord-020235-stcrozdw 155 36 BRIGITTE BRIGITTE NNP cord-020235-stcrozdw 155 37 The the DT cord-020235-stcrozdw 155 38 com com NN cord-020235-stcrozdw 155 39 plete plete NN cord-020235-stcrozdw 155 40 primary primary JJ cord-020235-stcrozdw 155 41 struc struc JJ cord-020235-stcrozdw 155 42 tures ture NNS cord-020235-stcrozdw 155 43 of of IN cord-020235-stcrozdw 155 44 the the DT cord-020235-stcrozdw 155 45 core core NN cord-020235-stcrozdw 155 46 proteins protein NNS cord-020235-stcrozdw 155 47 of of IN cord-020235-stcrozdw 155 48 Sindbis Sindbis NNP cord-020235-stcrozdw 155 49 and and CC cord-020235-stcrozdw 155 50 Semliki Semliki NNP cord-020235-stcrozdw 155 51 Forest Forest NNP cord-020235-stcrozdw 155 52 virus virus NN cord-020235-stcrozdw 155 53 have have VBP cord-020235-stcrozdw 155 54 been be VBN cord-020235-stcrozdw 155 55 established establish VBN cord-020235-stcrozdw 155 56 by by IN cord-020235-stcrozdw 155 57 pr pr NNP cord-020235-stcrozdw 155 58 ote ote NNP cord-020235-stcrozdw 155 59 inchemical inchemical JJ cord-020235-stcrozdw 155 60 methods method NNS cord-020235-stcrozdw 155 61 . . . cord-020235-stcrozdw 156 1 Both both DT cord-020235-stcrozdw 156 2 proteins protein NNS cord-020235-stcrozdw 156 3 contain contain VBP cord-020235-stcrozdw 156 4 clusters cluster NNS cord-020235-stcrozdw 156 5 of of IN cord-020235-stcrozdw 156 6 basic basic JJ cord-020235-stcrozdw 156 7 amino amino NN cord-020235-stcrozdw 156 8 acids acid NNS cord-020235-stcrozdw 156 9 and and CC cord-020235-stcrozdw 156 10 proline proline NN cord-020235-stcrozdw 156 11 in in RP cord-020235-stcrozdw 156 12 th th XX cord-020235-stcrozdw 156 13 e e NN cord-020235-stcrozdw 156 14 N n NN cord-020235-stcrozdw 156 15 - - HYPH cord-020235-stcrozdw 156 16 terminal terminal JJ cord-020235-stcrozdw 156 17 part part NN cord-020235-stcrozdw 156 18 , , , cord-020235-stcrozdw 156 19 suggesting suggest VBG cord-020235-stcrozdw 156 20 th th XX cord-020235-stcrozdw 156 21 at at IN cord-020235-stcrozdw 156 22 its -PRON- PRP$ cord-020235-stcrozdw 156 23 function function NN cord-020235-stcrozdw 156 24 is be VBZ cord-020235-stcrozdw 156 25 to to TO cord-020235-stcrozdw 156 26 bind bind VB cord-020235-stcrozdw 156 27 to to IN cord-020235-stcrozdw 156 28 the the DT cord-020235-stcrozdw 156 29 nucle nucle NNP cord-020235-stcrozdw 156 30 ic ic NNP cord-020235-stcrozdw 156 31 acid acid NNP cord-020235-stcrozdw 156 32 . . . cord-020235-stcrozdw 157 1 The the DT cord-020235-stcrozdw 157 2 C C NNP cord-020235-stcrozdw 157 3 - - HYPH cord-020235-stcrozdw 157 4 termi termi NNP cord-020235-stcrozdw 157 5 nal nal NNP cord-020235-stcrozdw 157 6 pa pa NNP cord-020235-stcrozdw 157 7 rts rts NNP cord-020235-stcrozdw 157 8 have have VBP cord-020235-stcrozdw 157 9 ext ext NNP cord-020235-stcrozdw 157 10 ensive ensive NNP cord-020235-stcrozdw 157 11 iden iden NNP cord-020235-stcrozdw 157 12 tical tical JJ cord-020235-stcrozdw 157 13 sequence sequence NN cord-020235-stcrozdw 157 14 regions region NNS cord-020235-stcrozdw 157 15 , , , cord-020235-stcrozdw 157 16 pr pr NNP cord-020235-stcrozdw 157 17 ob ob NNP cord-020235-stcrozdw 157 18 abl abl NNP cord-020235-stcrozdw 157 19 y y NNP cord-020235-stcrozdw 157 20 p p NNP cord-020235-stcrozdw 157 21 roviding rovide VBG cord-020235-stcrozdw 157 22 the the DT cord-020235-stcrozdw 157 23 recognition recognition NN cord-020235-stcrozdw 157 24 sites site NNS cord-020235-stcrozdw 157 25 for for IN cord-020235-stcrozdw 157 26 pr pr NNP cord-020235-stcrozdw 157 27 otein otein NNP cord-020235-stcrozdw 157 28 - - HYPH cord-020235-stcrozdw 157 29 protein protein NN cord-020235-stcrozdw 157 30 interactions interaction NNS cord-020235-stcrozdw 157 31 . . . cord-020235-stcrozdw 158 1 Both both DT cord-020235-stcrozdw 158 2 proteins protein NNS cord-020235-stcrozdw 158 3 contain contain VBP cord-020235-stcrozdw 158 4 within within IN cord-020235-stcrozdw 158 5 these these DT cord-020235-stcrozdw 158 6 highl highl NNP cord-020235-stcrozdw 158 7 y y NNP cord-020235-stcrozdw 158 8 conserved conserve VBD cord-020235-stcrozdw 158 9 portion portion NN cord-020235-stcrozdw 158 10 s s VBZ cord-020235-stcrozdw 158 11 the the DT cord-020235-stcrozdw 158 12 sequence sequence NN cord-020235-stcrozdw 159 1 Gly Gly NNP cord-020235-stcrozdw 159 2 - - HYPH cord-020235-stcrozdw 159 3 Asp Asp NNP cord-020235-stcrozdw 159 4 - - HYPH cord-020235-stcrozdw 159 5 Ser Ser NNP cord-020235-stcrozdw 159 6 - - HYPH cord-020235-stcrozdw 159 7 Gly Gly NNP cord-020235-stcrozdw 159 8 wh wh NNP cord-020235-stcrozdw 159 9 ich ich NNP cord-020235-stcrozdw 159 10 is be VBZ cord-020235-stcrozdw 159 11 typical typical JJ cord-020235-stcrozdw 159 12 for for IN cord-020235-stcrozdw 159 13 serine serine JJ cord-020235-stcrozdw 159 14 proteases protease NNS cord-020235-stcrozdw 159 15 and and CC cord-020235-stcrozdw 159 16 most most RBS cord-020235-stcrozdw 159 17 likely likely RB cord-020235-stcrozdw 159 18 is be VBZ cord-020235-stcrozdw 159 19 related relate VBN cord-020235-stcrozdw 159 20 to to IN cord-020235-stcrozdw 159 21 the the DT cord-020235-stcrozdw 159 22 cata cata NNP cord-020235-stcrozdw 159 23 lytic lytic JJ cord-020235-stcrozdw 159 24 function function NN cord-020235-stcrozdw 159 25 of of IN cord-020235-stcrozdw 159 26 the the DT cord-020235-stcrozdw 159 27 core core NN cord-020235-stcrozdw 159 28 prot prot NNP cord-020235-stcrozdw 159 29 ein ein NNP cord-020235-stcrozdw 159 30 as as IN cord-020235-stcrozdw 159 31 a a DT cord-020235-stcrozdw 159 32 protease protease NN cord-020235-stcrozdw 159 33 wh wh FW cord-020235-stcrozdw 159 34 en en FW cord-020235-stcrozdw 159 35 cleaving cleave VBG cord-020235-stcrozdw 159 36 its -PRON- PRP$ cord-020235-stcrozdw 159 37 own own JJ cord-020235-stcrozdw 159 38 peptide peptide NN cord-020235-stcrozdw 159 39 chai chai NN cord-020235-stcrozdw 159 40 n n CC cord-020235-stcrozdw 159 41 from from IN cord-020235-stcrozdw 159 42 the the DT cord-020235-stcrozdw 159 43 nascent nascent JJ cord-020235-stcrozdw 159 44 protein protein NN cord-020235-stcrozdw 159 45 precursor precursor NN cord-020235-stcrozdw 159 46 . . . cord-020235-stcrozdw 160 1 Experimental experimental JJ cord-020235-stcrozdw 160 2 studies study NNS cord-020235-stcrozdw 160 3 using use VBG cord-020235-stcrozdw 160 4 peptides peptide NNS cord-020235-stcrozdw 160 5 which which WDT cord-020235-stcrozdw 160 6 contain contain VBP cord-020235-stcrozdw 160 7 certai certai NNP cord-020235-stcrozdw 160 8 n n NN cord-020235-stcrozdw 160 9 sequence sequence NN cord-020235-stcrozdw 160 10 regions region NNS cord-020235-stcrozdw 160 11 will will MD cord-020235-stcrozdw 160 12 help help VB cord-020235-stcrozdw 160 13 to to TO cord-020235-stcrozdw 160 14 elucidate elucidate VB cord-020235-stcrozdw 160 15 the the DT cord-020235-stcrozdw 160 16 relationships relationship NNS cord-020235-stcrozdw 160 17 of of IN cord-020235-stcrozdw 160 18 struc struc NNP cord-020235-stcrozdw 160 19 ture ture NNP cord-020235-stcrozdw 160 20 and and CC cord-020235-stcrozdw 160 21 functions function NNS cord-020235-stcrozdw 160 22 . . . cord-020235-stcrozdw 161 1 An an DT cord-020235-stcrozdw 161 2 ac ac NN cord-020235-stcrozdw 161 3 ute ute NN cord-020235-stcrozdw 161 4 and and CC cord-020235-stcrozdw 161 5 a a DT cord-020235-stcrozdw 161 6 persistent persistent JJ cord-020235-stcrozdw 161 7 infectio infectio NNP cord-020235-stcrozdw 161 8 n n NNP cord-020235-stcrozdw 161 9 with with IN cord-020235-stcrozdw 161 10 Rab Rab NNP cord-020235-stcrozdw 161 11 ies ies NNP cord-020235-stcrozdw 161 12 virus virus NN cord-020235-stcrozdw 162 1 ( ( -LRB- cord-020235-stcrozdw 162 2 H H NNP cord-020235-stcrozdw 162 3 EP EP NNP cord-020235-stcrozdw 162 4 Flury Flury NNP cord-020235-stcrozdw 162 5 ) ) -RRB- cord-020235-stcrozdw 162 6 was be VBD cord-020235-stcrozdw 162 7 established establish VBN cord-020235-stcrozdw 162 8 in in IN cord-020235-stcrozdw 162 9 th th XX cord-020235-stcrozdw 162 10 e e NN cord-020235-stcrozdw 162 11 CN cn NN cord-020235-stcrozdw 162 12 S S NNP cord-020235-stcrozdw 162 13 - - HYPH cord-020235-stcrozdw 162 14 derive derive VBP cord-020235-stcrozdw 162 15 d d NN cord-020235-stcrozdw 162 16 cell cell NN cord-020235-stcrozdw 162 17 1ine 1ine CD cord-020235-stcrozdw 162 18 108-CC 108-cc CD cord-020235-stcrozdw 162 19 - - HYPH cord-020235-stcrozdw 162 20 I5 I5 NNP cord-020235-stcrozdw 162 21 ( ( -LRB- cord-020235-stcrozdw 162 22 NG NG NNP cord-020235-stcrozdw 162 23 108 108 CD cord-020235-stcrozdw 162 24 - - SYM cord-020235-stcrozdw 162 25 15 15 CD cord-020235-stcrozdw 162 26 ) ) -RRB- cord-020235-stcrozdw 162 27 . . . cord-020235-stcrozdw 163 1 These these DT cord-020235-stcrozdw 163 2 cells cell NNS cord-020235-stcrozdw 163 3 possess possess VBP cord-020235-stcrozdw 163 4 specific specific JJ cord-020235-stcrozdw 163 5 membrane membrane NN cord-020235-stcrozdw 163 6 recept recept NNP cord-020235-stcrozdw 163 7 ors ors NNP cord-020235-stcrozdw 163 8 to to IN cord-020235-stcrozdw 163 9 many many JJ cord-020235-stcrozdw 163 10 hormon hormon NN cord-020235-stcrozdw 163 11 es es NNP cord-020235-stcrozdw 163 12 and and CC cord-020235-stcrozdw 163 13 neurotran neurotran NNP cord-020235-stcrozdw 163 14 smitters smitters NNPS cord-020235-stcrozdw 163 15 including include VBG cord-020235-stcrozdw 163 16 opiate opiate NN cord-020235-stcrozdw 163 17 receptors receptor NNS cord-020235-stcrozdw 163 18 . . . cord-020235-stcrozdw 164 1 In in IN cord-020235-stcrozdw 164 2 both both DT cord-020235-stcrozdw 164 3 cases case NNS cord-020235-stcrozdw 164 4 we -PRON- PRP cord-020235-stcrozdw 164 5 found find VBD cord-020235-stcrozdw 164 6 increases increase NNS cord-020235-stcrozdw 164 7 in in IN cord-020235-stcrozdw 164 8 th th XX cord-020235-stcrozdw 164 9 e e NN cord-020235-stcrozdw 164 10 dissociation dissociation NN cord-020235-stcrozdw 164 11 constant constant NN cord-020235-stcrozdw 164 12 ( ( -LRB- cord-020235-stcrozdw 164 13 Kn Kn NNP cord-020235-stcrozdw 164 14 ) ) -RRB- cord-020235-stcrozdw 164 15 for for IN cord-020235-stcrozdw 164 16 the the DT cord-020235-stcrozdw 164 17 agonist agonist NN cord-020235-stcrozdw 164 18 3H 3H NNP cord-020235-stcrozdw 164 19 - - HYPH cord-020235-stcrozdw 164 20 etorp etorp NNP cord-020235-stcrozdw 164 21 hine hine NNP cord-020235-stcrozdw 164 22 as as IN cord-020235-stcrozdw 164 23 estimated estimate VBN cord-020235-stcrozdw 164 24 by by IN cord-020235-stcrozdw 164 25 Scatcha Scatcha NNP cord-020235-stcrozdw 164 26 rd rd NNP cord-020235-stcrozdw 164 27 plot plot NN cord-020235-stcrozdw 164 28 ana ana NNP cord-020235-stcrozdw 164 29 lysis lysis NN cord-020235-stcrozdw 164 30 . . . cord-020235-stcrozdw 165 1 H h NN cord-020235-stcrozdw 165 2 owe owe VBP cord-020235-stcrozdw 165 3 ver ver NN cord-020235-stcrozdw 165 4 , , , cord-020235-stcrozdw 165 5 in in IN cord-020235-stcrozdw 165 6 both both DT cord-020235-stcrozdw 165 7 cases case NNS cord-020235-stcrozdw 166 1 th th DT cord-020235-stcrozdw 166 2 ere ere NN cord-020235-stcrozdw 166 3 was be VBD cord-020235-stcrozdw 166 4 no no DT cord-020235-stcrozdw 166 5 change change NN cord-020235-stcrozdw 166 6 in in IN cord-020235-stcrozdw 166 7 th th XX cord-020235-stcrozdw 166 8 e e NN cord-020235-stcrozdw 167 1 nu nu NNP cord-020235-stcrozdw 167 2 mb mb NNP cord-020235-stcrozdw 167 3 er er UH cord-020235-stcrozdw 167 4 of of IN cord-020235-stcrozdw 167 5 op op NN cord-020235-stcrozdw 167 6 iat iat NNP cord-020235-stcrozdw 167 7 e e NN cord-020235-stcrozdw 167 8 receptors receptor NNS cord-020235-stcrozdw 167 9 per per IN cord-020235-stcrozdw 167 10 cell cell NN cord-020235-stcrozdw 167 11 compa compa NN cord-020235-stcrozdw 167 12 red red JJ cord-020235-stcrozdw 167 13 to to IN cord-020235-stcrozdw 167 14 uninfected uninfected JJ cord-020235-stcrozdw 167 15 cells cell NNS cord-020235-stcrozdw 167 16 . . . cord-020235-stcrozdw 168 1 These these DT cord-020235-stcrozdw 168 2 studies study NNS cord-020235-stcrozdw 168 3 complete complete VBP cord-020235-stcrozdw 168 4 our -PRON- PRP$ cord-020235-stcrozdw 168 5 previou previou NNP cord-020235-stcrozdw 168 6 s s NNP cord-020235-stcrozdw 168 7 published publish VBN cord-020235-stcrozdw 168 8 observations observation NNS cord-020235-stcrozdw 168 9 of of IN cord-020235-stcrozdw 168 10 the the DT cord-020235-stcrozdw 168 11 impai impai FW cord-020235-stcrozdw 168 12 rme rme NNP cord-020235-stcrozdw 168 13 nt nt RB cord-020235-stcrozdw 168 14 o o NN cord-020235-stcrozdw 168 15 f f NN cord-020235-stcrozdw 168 16 receptor receptor NN cord-020235-stcrozdw 168 17 func func NN cord-020235-stcrozdw 168 18 tions tion NNS cord-020235-stcrozdw 168 19 in in IN cord-020235-stcrozdw 168 20 rabies rabies NNP cord-020235-stcrozdw 168 21 virus virus NN cord-020235-stcrozdw 168 22 infe infe NNP cord-020235-stcrozdw 168 23 cted cte VBN cord-020235-stcrozdw 168 24 cells cell NNS cord-020235-stcrozdw 168 25 ( ( -LRB- cord-020235-stcrozdw 168 26 1 1 CD cord-020235-stcrozdw 168 27 ) ) -RRB- cord-020235-stcrozdw 168 28 . . . cord-020235-stcrozdw 169 1 ( ( -LRB- cord-020235-stcrozdw 169 2 1 1 LS cord-020235-stcrozdw 169 3 ) ) -RRB- cord-020235-stcrozdw 169 4 Kosch Kosch NNP cord-020235-stcrozdw 169 5 el el NNP cord-020235-stcrozdw 169 6 , , , cord-020235-stcrozdw 169 7 K. K. NNP cord-020235-stcrozdw 170 1 an an DT cord-020235-stcrozdw 170 2 d d XX cord-020235-stcrozdw 170 3 M. M. NNP cord-020235-stcrozdw 170 4 Halb Halb NNP cord-020235-stcrozdw 170 5 ach ach NN cord-020235-stcrozdw 170 6 : : : cord-020235-stcrozdw 170 7 J. J. NNP cord-020235-stcrozdw 170 8 Gen. Gen. NNP cord-020235-stcrozdw 170 9 Virol Virol NNP cord-020235-stcrozdw 170 10 . . . cord-020235-stcrozdw 170 11 42 42 CD cord-020235-stcrozdw 170 12 ( ( -LRB- cord-020235-stcrozdw 170 13 1979 1979 CD cord-020235-stcrozdw 170 14 ) ) -RRB- cord-020235-stcrozdw 170 15 , , , cord-020235-stcrozdw 170 16 627 627 CD cord-020235-stcrozdw 170 17 - - SYM cord-020235-stcrozdw 170 18 632 632 CD cord-020235-stcrozdw 170 19 . . . cord-020235-stcrozdw 171 1 Insr Insr NNP cord-020235-stcrozdw 171 2 , , , cord-020235-stcrozdw 171 3 f. f. NN cord-020235-stcrozdw 171 4 Virologic Virologic NNP cord-020235-stcrozdw 171 5 u. u. NNP cord-020235-stcrozdw 171 6 Immunobi Immunobi NNP cord-020235-stcrozdw 171 7 olo olo NNP cord-020235-stcrozdw 171 8 gie gie NNP cord-020235-stcrozdw 171 9 d. d. NNP cord-020235-stcrozdw 171 10 Univ Univ NNP cord-020235-stcrozdw 171 11 . . NNP cord-020235-stcrozdw 171 12 , , , cord-020235-stcrozdw 171 13 0 0 CD cord-020235-stcrozdw 171 14 - - SYM cord-020235-stcrozdw 171 15 8700 8700 CD cord-020235-stcrozdw 172 1 Wiirzburg Wiirzburg NNP cord-020235-stcrozdw 172 2 Effect Effect NNP cord-020235-stcrozdw 172 3 of of IN cord-020235-stcrozdw 172 4 Measles Measles NNP cord-020235-stcrozdw 172 5 ( ( -LRB- cord-020235-stcrozdw 172 6 SSPE SSPE NNP cord-020235-stcrozdw 172 7 ) ) -RRB- cord-020235-stcrozdw 173 1 Antiserum antiserum NN cord-020235-stcrozdw 173 2 on on IN cord-020235-stcrozdw 173 3 Viral Viral NNP cord-020235-stcrozdw 173 4 Surface Surface NNP cord-020235-stcrozdw 173 5 Proteins Proteins NNPS cord-020235-stcrozdw 173 6 and and CC cord-020235-stcrozdw 173 7 Hormone Hormone NNP cord-020235-stcrozdw 173 8 Receptor Receptor NNP cord-020235-stcrozdw 173 9 Activity Activity NNP cord-020235-stcrozdw 173 10 in in IN cord-020235-stcrozdw 173 11 C6 C6 NNP cord-020235-stcrozdw 173 12 / / SYM cord-020235-stcrozdw 173 13 SSPE SSPE NNP cord-020235-stcrozdw 173 14 Persistently persistently RB cord-020235-stcrozdw 174 1 Infected Infected NNP cord-020235-stcrozdw 174 2 Cells cell NNS cord-020235-stcrozdw 174 3 BARRETT BARRETT NNP cord-020235-stcrozdw 174 4 , , , cord-020235-stcrozdw 174 5 P. P. NNP cord-020235-stcrozdw 174 6 N. N. NNP cord-020235-stcrozdw 174 7 and and CC cord-020235-stcrozdw 174 8 KOSCHEL KOSCHEL NNP cord-020235-stcrozdw 174 9 , , , cord-020235-stcrozdw 175 1 K. K. NNP cord-020235-stcrozdw 176 1 It -PRON- PRP cord-020235-stcrozdw 176 2 has have VBZ cord-020235-stcrozdw 176 3 been be VBN cord-020235-stcrozdw 176 4 reported report VBN cord-020235-stcrozdw 177 1 ( ( -LRB- cord-020235-stcrozdw 177 2 1 1 LS cord-020235-stcrozdw 177 3 ) ) -RRB- cord-020235-stcrozdw 177 4 th th XX cord-020235-stcrozdw 177 5 at at IN cord-020235-stcrozdw 177 6 measles measles NNP cord-020235-stcrozdw 177 7 antis antis NNP cord-020235-stcrozdw 177 8 erum erum NNP cord-020235-stcrozdw 177 9 ca ca NNP cord-020235-stcrozdw 177 10 n n CC cord-020235-stcrozdw 177 11 modulate modulate VB cord-020235-stcrozdw 177 12 the the DT cord-020235-stcrozdw 177 13 expression expression NN cord-020235-stcrozdw 177 14 of of IN cord-020235-stcrozdw 177 15 certain certain JJ cord-020235-stcrozdw 177 16 viru viru NNP cord-020235-stcrozdw 177 17 s s POS cord-020235-stcrozdw 177 18 prot prot NNP cord-020235-stcrozdw 177 19 eins eins NNP cord-020235-stcrozdw 177 20 in in IN cord-020235-stcrozdw 177 21 acu acu NNP cord-020235-stcrozdw 177 22 tely tely NNP cord-020235-stcrozdw 177 23 measles measles NNP cord-020235-stcrozdw 177 24 infected infected JJ cord-020235-stcrozdw 177 25 cells cell NNS cord-020235-stcrozdw 177 26 . . . cord-020235-stcrozdw 178 1 We -PRON- PRP cord-020235-stcrozdw 178 2 have have VBP cord-020235-stcrozdw 178 3 exam exam NN cord-020235-stcrozdw 178 4 ined ined XX cord-020235-stcrozdw 178 5 th th XX cord-020235-stcrozdw 178 6 e e NN cord-020235-stcrozdw 178 7 effect effect NN cord-020235-stcrozdw 178 8 of of IN cord-020235-stcrozdw 178 9 measles measle NNS cord-020235-stcrozdw 178 10 ( ( -LRB- cord-020235-stcrozdw 178 11 SSPE SSPE NNP cord-020235-stcrozdw 178 12 ) ) -RRB- cord-020235-stcrozdw 178 13 antiserum antiserum NN cord-020235-stcrozdw 178 14 on on IN cord-020235-stcrozdw 178 15 the the DT cord-020235-stcrozdw 178 16 exp exp NNP cord-020235-stcrozdw 178 17 ressio ressio NNP cord-020235-stcrozdw 178 18 n n NNP cord-020235-stcrozdw 178 19 of of IN cord-020235-stcrozdw 178 20 vira vira NNP cord-020235-stcrozdw 178 21 l l NNP cord-020235-stcrozdw 178 22 surface surface NN cord-020235-stcrozdw 178 23 proteins protein NNS cord-020235-stcrozdw 178 24 in in IN cord-020235-stcrozdw 178 25 C6ISSPE C6ISSPE NNP cord-020235-stcrozdw 178 26 infected infected JJ cord-020235-stcrozdw 178 27 cells cell NNS cord-020235-stcrozdw 178 28 . . . cord-020235-stcrozdw 179 1 We -PRON- PRP cord-020235-stcrozdw 179 2 have have VBP cord-020235-stcrozdw 179 3 shown show VBN cord-020235-stcrozdw 179 4 an an DT cord-020235-stcrozdw 179 5 over over IN cord-020235-stcrozdw 179 6 50 50 CD cord-020235-stcrozdw 179 7 % % NN cord-020235-stcrozdw 179 8 redu redu NN cord-020235-stcrozdw 179 9 ction ction NN cord-020235-stcrozdw 179 10 in in IN cord-020235-stcrozdw 179 11 the the DT cord-020235-stcrozdw 179 12 am am NNP cord-020235-stcrozdw 179 13 ount ount NN cord-020235-stcrozdw 179 14 of of IN cord-020235-stcrozdw 179 15 viral viral JJ cord-020235-stcrozdw 179 16 antigen antigen NN cord-020235-stcrozdw 179 17 present present JJ cord-020235-stcrozdw 179 18 on on IN cord-020235-stcrozdw 179 19 the the DT cord-020235-stcrozdw 179 20 memb memb NNP cord-020235-stcrozdw 179 21 ranes rane NNS cord-020235-stcrozdw 179 22 of of IN cord-020235-stcrozdw 179 23 these these DT cord-020235-stcrozdw 179 24 cells cell NNS cord-020235-stcrozdw 179 25 following follow VBG cord-020235-stcrozdw 179 26 incuba incuba NNP cord-020235-stcrozdw 179 27 tion tion NN cord-020235-stcrozdw 179 28 with with IN cord-020235-stcrozdw 179 29 SSPE SSPE NNP cord-020235-stcrozdw 179 30 antiserum antiserum NN cord-020235-stcrozdw 179 31 . . . cord-020235-stcrozdw 180 1 This this DT cord-020235-stcrozdw 180 2 was be VBD cord-020235-stcrozdw 180 3 demon demon NN cord-020235-stcrozdw 180 4 - - , cord-020235-stcrozdw 180 5 strated strate VBN cord-020235-stcrozdw 180 6 both both CC cord-020235-stcrozdw 180 7 by by IN cord-020235-stcrozdw 180 8 immunofluorescence immunofluorescence NN cord-020235-stcrozdw 180 9 and and CC cord-020235-stcrozdw 180 10 rad rad NNP cord-020235-stcrozdw 180 11 ioimmunoassay ioimmunoassay NNP cord-020235-stcrozdw 180 12 . . . cord-020235-stcrozdw 181 1 However however RB cord-020235-stcrozdw 181 2 this this DT cord-020235-stcrozdw 181 3 loss loss NN cord-020235-stcrozdw 181 4 of of IN cord-020235-stcrozdw 181 5 antigen antigen NN cord-020235-stcrozdw 181 6 had have VBD cord-020235-stcrozdw 181 7 no no DT cord-020235-stcrozdw 181 8 effect effect NN cord-020235-stcrozdw 181 9 on on IN cord-020235-stcrozdw 181 10 memb memb NNP cord-020235-stcrozdw 181 11 rane rane NNP cord-020235-stcrozdw 181 12 receptor receptor NNP cord-020235-stcrozdw 181 13 linked link VBD cord-020235-stcrozdw 181 14 cAMP camp NN cord-020235-stcrozdw 181 15 synthesis synthesis NN cord-020235-stcrozdw 181 16 . . . cord-020235-stcrozdw 182 1 This this DT cord-020235-stcrozdw 182 2 is be VBZ cord-020235-stcrozdw 182 3 discussed discuss VBN cord-020235-stcrozdw 182 4 with with IN cord-020235-stcrozdw 182 5 respect respect NN cord-020235-stcrozdw 182 6 to to IN cord-020235-stcrozdw 182 7 the the DT cord-020235-stcrozdw 182 8 effect effect NN cord-020235-stcrozdw 182 9 of of IN cord-020235-stcrozdw 182 10 virus virus NN cord-020235-stcrozdw 182 11 antigen antigen NN cord-020235-stcrozdw 182 12 insertion insertion NN cord-020235-stcrozdw 182 13 in in IN cord-020235-stcrozdw 182 14 cell cell NN cord-020235-stcrozdw 182 15 membranes membrane NNS cord-020235-stcrozdw 182 16 on on IN cord-020235-stcrozdw 182 17 specialised specialised JJ cord-020235-stcrozdw 182 18 membrane membrane NN cord-020235-stcrozdw 182 19 bound bind VBN cord-020235-stcrozdw 182 20 functions function NNS cord-020235-stcrozdw 182 21 . . . cord-020235-stcrozdw 183 1 ( ( -LRB- cord-020235-stcrozdw 183 2 1 1 LS cord-020235-stcrozdw 183 3 ) ) -RRB- cord-020235-stcrozdw 183 4 We -PRON- PRP cord-020235-stcrozdw 183 5 have have VBP cord-020235-stcrozdw 183 6 analyzed analyze VBN cord-020235-stcrozdw 183 7 the the DT cord-020235-stcrozdw 183 8 effect effect NN cord-020235-stcrozdw 183 9 of of IN cord-020235-stcrozdw 183 10 phosphorylation phosphorylation NN cord-020235-stcrozdw 183 11 and and CC cord-020235-stcrozdw 183 12 dephosphorylation dephosphorylation NN cord-020235-stcrozdw 183 13 on on IN cord-020235-stcrozdw 183 14 the the DT cord-020235-stcrozdw 183 15 structure structure NN cord-020235-stcrozdw 183 16 and and CC cord-020235-stcrozdw 183 17 DNA dna NN cord-020235-stcrozdw 183 18 binding binding NN cord-020235-stcrozdw 183 19 of of IN cord-020235-stcrozdw 183 20 D2-T D2-T `` cord-020235-stcrozdw 183 21 antigen antigen NN cord-020235-stcrozdw 183 22 . . . cord-020235-stcrozdw 184 1 On on IN cord-020235-stcrozdw 184 2 non non JJ cord-020235-stcrozdw 184 3 - - JJ cord-020235-stcrozdw 184 4 denaturing denaturing JJ cord-020235-stcrozdw 184 5 pore pore NN cord-020235-stcrozdw 184 6 - - HYPH cord-020235-stcrozdw 184 7 gradient gradient NN cord-020235-stcrozdw 184 8 gels gel NNS cord-020235-stcrozdw 184 9 the the DT cord-020235-stcrozdw 184 10 purified purify VBN cord-020235-stcrozdw 184 11 protein protein NN cord-020235-stcrozdw 184 12 migrated migrate VBD cord-020235-stcrozdw 184 13 with with IN cord-020235-stcrozdw 184 14 an an DT cord-020235-stcrozdw 184 15 apparent apparent JJ cord-020235-stcrozdw 184 16 size size NN cord-020235-stcrozdw 184 17 of of IN cord-020235-stcrozdw 184 18 135,000 135,000 CD cord-020235-stcrozdw 184 19 daltons dalton NNS cord-020235-stcrozdw 184 20 , , , cord-020235-stcrozdw 184 21 In in IN cord-020235-stcrozdw 184 22 vitro vitro FW cord-020235-stcrozdw 184 23 phosphorylation phosphorylation NN cord-020235-stcrozdw 184 24 by by IN cord-020235-stcrozdw 184 25 the the DT cord-020235-stcrozdw 184 26 protein protein NN cord-020235-stcrozdw 184 27 kinase kinase NN cord-020235-stcrozdw 184 28 associated associate VBN cord-020235-stcrozdw 184 29 with with IN cord-020235-stcrozdw 184 30 the the DT cord-020235-stcrozdw 184 31 purified purify VBN cord-020235-stcrozdw 184 32 protein protein NN cord-020235-stcrozdw 184 33 resulted result VBD cord-020235-stcrozdw 184 34 in in IN cord-020235-stcrozdw 184 35 a a DT cord-020235-stcrozdw 184 36 shift shift NN cord-020235-stcrozdw 184 37 of of IN cord-020235-stcrozdw 184 38 most most JJS cord-020235-stcrozdw 184 39 of of IN cord-020235-stcrozdw 184 40 the the DT cord-020235-stcrozdw 184 41 protein protein NN cord-020235-stcrozdw 184 42 to to IN cord-020235-stcrozdw 184 43 a a DT cord-020235-stcrozdw 184 44 size size NN cord-020235-stcrozdw 184 45 of of IN cord-020235-stcrozdw 184 46 740,000 740,000 CD cord-020235-stcrozdw 184 47 daltons dalton NNS cord-020235-stcrozdw 184 48 , , , cord-020235-stcrozdw 184 49 and and CC cord-020235-stcrozdw 184 50 it -PRON- PRP cord-020235-stcrozdw 184 51 was be VBD cord-020235-stcrozdw 184 52 this this DT cord-020235-stcrozdw 184 53 form form NN cord-020235-stcrozdw 184 54 that that WDT cord-020235-stcrozdw 184 55 contained contain VBD cord-020235-stcrozdw 184 56 most most JJS cord-020235-stcrozdw 184 57 of of IN cord-020235-stcrozdw 184 58 the the DT cord-020235-stcrozdw 184 59 phosphate phosphate NN cord-020235-stcrozdw 184 60 incorporated incorporate VBN cord-020235-stcrozdw 184 61 . . . cord-020235-stcrozdw 185 1 This this DT cord-020235-stcrozdw 185 2 aggregation aggregation NN cord-020235-stcrozdw 185 3 was be VBD cord-020235-stcrozdw 185 4 completely completely RB cord-020235-stcrozdw 185 5 reversible reversible JJ cord-020235-stcrozdw 185 6 by by IN cord-020235-stcrozdw 185 7 treatment treatment NN cord-020235-stcrozdw 185 8 of of IN cord-020235-stcrozdw 185 9 phosphorylated phosphorylated JJ cord-020235-stcrozdw 185 10 D2-T D2-T NNP cord-020235-stcrozdw 185 11 antigen antigen NN cord-020235-stcrozdw 185 12 with with IN cord-020235-stcrozdw 185 13 alkaline alkaline JJ cord-020235-stcrozdw 185 14 phosphatase phosphatase NN cord-020235-stcrozdw 185 15 . . . cord-020235-stcrozdw 186 1 Partial partial JJ cord-020235-stcrozdw 186 2 tryptic tryptic JJ cord-020235-stcrozdw 186 3 digestion digestion NN cord-020235-stcrozdw 186 4 indicated indicate VBD cord-020235-stcrozdw 186 5 that that IN cord-020235-stcrozdw 186 6 phosphorylation phosphorylation NN cord-020235-stcrozdw 186 7 of of IN cord-020235-stcrozdw 186 8 sites site NNS cord-020235-stcrozdw 186 9 in in IN cord-020235-stcrozdw 186 10 the the DT cord-020235-stcrozdw 186 11 Nvrerminal nvrerminal JJ cord-020235-stcrozdw 186 12 part part NN cord-020235-stcrozdw 186 13 of of IN cord-020235-stcrozdw 186 14 the the DT cord-020235-stcrozdw 186 15 protein protein NN cord-020235-stcrozdw 186 16 is be VBZ cord-020235-stcrozdw 186 17 responsible responsible JJ cord-020235-stcrozdw 186 18 for for IN cord-020235-stcrozdw 186 19 the the DT cord-020235-stcrozdw 186 20 observed observed JJ cord-020235-stcrozdw 186 21 aggregation aggregation NN cord-020235-stcrozdw 186 22 . . . cord-020235-stcrozdw 187 1 -As -As : cord-020235-stcrozdw 187 2 show show NN cord-020235-stcrozdw 187 3 n n NNP cord-020235-stcrozdw 187 4 by by IN cord-020235-stcrozdw 187 5 protein protein NN cord-020235-stcrozdw 187 6 blotting blot VBG cord-020235-stcrozdw 187 7 onto onto IN cord-020235-stcrozdw 187 8 nitrocellulose nitrocellulose VBG cord-020235-stcrozdw 187 9 filters filter NNS cord-020235-stcrozdw 187 10 predominantly predominantly RB cord-020235-stcrozdw 187 11 the the DT cord-020235-stcrozdw 187 12 740,000 740,000 CD cord-020235-stcrozdw 187 13 dalton dalton NNP cord-020235-stcrozdw 187 14 form form NN cord-020235-stcrozdw 187 15 bound bind VBN cord-020235-stcrozdw 187 16 to to IN cord-020235-stcrozdw 187 17 SV40 SV40 NNP cord-020235-stcrozdw 187 18 DNA DNA NNP cord-020235-stcrozdw 187 19 . . . cord-020235-stcrozdw 188 1 However however RB cord-020235-stcrozdw 188 2 , , , cord-020235-stcrozdw 188 3 onl onl NNP cord-020235-stcrozdw 188 4 y y NNP cord-020235-stcrozdw 188 5 a a DT cord-020235-stcrozdw 188 6 fraction fraction NN cord-020235-stcrozdw 188 7 of of IN cord-020235-stcrozdw 188 8 the the DT cord-020235-stcrozdw 188 9 in in FW cord-020235-stcrozdw 188 10 vitro vitro FW cord-020235-stcrozdw 188 11 phosphorylated phosphorylated JJ cord-020235-stcrozdw 188 12 protein protein NN cord-020235-stcrozdw 188 13 did do VBD cord-020235-stcrozdw 188 14 bind bind VB cord-020235-stcrozdw 188 15 to to IN cord-020235-stcrozdw 188 16 DNA DNA NNP cord-020235-stcrozdw 188 17 , , , cord-020235-stcrozdw 188 18 suggesting suggest VBG cord-020235-stcrozdw 188 19 that that IN cord-020235-stcrozdw 188 20 aggregation aggregation NN cord-020235-stcrozdw 188 21 alone alone RB cord-020235-stcrozdw 188 22 is be VBZ cord-020235-stcrozdw 188 23 not not RB cord-020235-stcrozdw 188 24 sufficient sufficient JJ cord-020235-stcrozdw 188 25 for for IN cord-020235-stcrozdw 188 26 DNA dna NN cord-020235-stcrozdw 188 27 bind bind VBP cord-020235-stcrozdw 188 28 ing ing NN cord-020235-stcrozdw 188 29 . . . cord-020235-stcrozdw 189 1 Subclasses subclass NNS cord-020235-stcrozdw 189 2 of of IN cord-020235-stcrozdw 189 3 SV40 SV40 NNP cord-020235-stcrozdw 189 4 large large JJ cord-020235-stcrozdw 189 5 T t NN cord-020235-stcrozdw 189 6 antigen antigen NN cord-020235-stcrozdw 189 7 were be VBD cord-020235-stcrozdw 189 8 separated separate VBN cord-020235-stcrozdw 189 9 by by IN cord-020235-stcrozdw 189 10 zone zone NN cord-020235-stcrozdw 189 11 velocity velocity NN cord-020235-stcrozdw 189 12 sedimentation sedimentation NN cord-020235-stcrozdw 189 13 . . . cord-020235-stcrozdw 190 1 Three three CD cord-020235-stcrozdw 190 2 major major JJ cord-020235-stcrozdw 190 3 forms form NNS cord-020235-stcrozdw 190 4 , , , cord-020235-stcrozdw 190 5 which which WDT cord-020235-stcrozdw 190 6 sedirnented sedirnente VBD cord-020235-stcrozdw 190 7 at at IN cord-020235-stcrozdw 190 8 about about RB cord-020235-stcrozdw 190 9 5 5 CD cord-020235-stcrozdw 190 10 - - HYPH cord-020235-stcrozdw 190 11 6S 6S NNP cord-020235-stcrozdw 190 12 , , , cord-020235-stcrozdw 190 13 14 14 CD cord-020235-stcrozdw 190 14 - - SYM cord-020235-stcrozdw 190 15 16S 16s CD cord-020235-stcrozdw 190 16 and and CC cord-020235-stcrozdw 190 17 23 23 CD cord-020235-stcrozdw 190 18 - - SYM cord-020235-stcrozdw 190 19 255 255 CD cord-020235-stcrozdw 190 20 , , , cord-020235-stcrozdw 190 21 have have VBP cord-020235-stcrozdw 190 22 been be VBN cord-020235-stcrozdw 190 23 shown show VBN cord-020235-stcrozdw 190 24 to to TO cord-020235-stcrozdw 190 25 differ differ VB cord-020235-stcrozdw 190 26 biologically biologically RB cord-020235-stcrozdw 190 27 and and CC cord-020235-stcrozdw 190 28 biochemically biochemically RB cord-020235-stcrozdw 190 29 ( ( -LRB- cord-020235-stcrozdw 190 30 1 1 CD cord-020235-stcrozdw 190 31 ) ) -RRB- cord-020235-stcrozdw 190 32 . . . cord-020235-stcrozdw 191 1 Each each DT cord-020235-stcrozdw 191 2 subclass subclass NN cord-020235-stcrozdw 191 3 was be VBD cord-020235-stcrozdw 191 4 tested test VBN cord-020235-stcrozdw 191 5 for for IN cord-020235-stcrozdw 191 6 specific specific JJ cord-020235-stcrozdw 191 7 binding binding NN cord-020235-stcrozdw 191 8 to to IN cord-020235-stcrozdw 191 9 restriction restriction NN cord-020235-stcrozdw 191 10 fragments fragment NNS cord-020235-stcrozdw 191 11 of of IN cord-020235-stcrozdw 191 12 SV40 SV40 NNP cord-020235-stcrozdw 191 13 DNA DNA NNP cord-020235-stcrozdw 191 14 using use VBG cord-020235-stcrozdw 191 15 an an DT cord-020235-stcrozdw 191 16 immunoprecipitation immunoprecipitation NN cord-020235-stcrozdw 191 17 assay assay NN cord-020235-stcrozdw 191 18 . . . cord-020235-stcrozdw 192 1 -All -All : cord-020235-stcrozdw 193 1 three three CD cord-020235-stcrozdw 193 2 forms form NNS cord-020235-stcrozdw 193 3 of of IN cord-020235-stcrozdw 193 4 T T NNP cord-020235-stcrozdw 193 5 antigen antigen NN cord-020235-stcrozdw 193 6 bound bind VBN cord-020235-stcrozdw 193 7 specifically specifically RB cord-020235-stcrozdw 193 8 to to IN cord-020235-stcrozdw 193 9 a a DT cord-020235-stcrozdw 193 10 restriction restriction NN cord-020235-stcrozdw 193 11 fragment fragment NN cord-020235-stcrozdw 193 12 containing contain VBG cord-020235-stcrozdw 193 13 the the DT cord-020235-stcrozdw 193 14 SV40 SV40 NNP cord-020235-stcrozdw 193 15 origin origin NN cord-020235-stcrozdw 193 16 of of IN cord-020235-stcrozdw 193 17 replication replication NN cord-020235-stcrozdw 193 18 . . . cord-020235-stcrozdw 194 1 However however RB cord-020235-stcrozdw 194 2 , , , cord-020235-stcrozdw 194 3 the the DT cord-020235-stcrozdw 194 4 5 5 CD cord-020235-stcrozdw 194 5 - - HYPH cord-020235-stcrozdw 194 6 6S 6S NNP cord-020235-stcrozdw 194 7 form form NN cord-020235-stcrozdw 194 8 bound bind VBN cord-020235-stcrozdw 194 9 more more JJR cord-020235-stcrozdw 194 10 origin origin NN cord-020235-stcrozdw 194 11 fragment fragment NN cord-020235-stcrozdw 194 12 per per IN cord-020235-stcrozdw 194 13 unit unit NN cord-020235-stcrozdw 194 14 T t CD cord-020235-stcrozdw 194 15 antigen antigen NN cord-020235-stcrozdw 194 16 than than IN cord-020235-stcrozdw 194 17 the the DT cord-020235-stcrozdw 194 18 other other JJ cord-020235-stcrozdw 194 19 forms form NNS cord-020235-stcrozdw 194 20 . . . cord-020235-stcrozdw 195 1 The the DT cord-020235-stcrozdw 195 2 5 5 CD cord-020235-stcrozdw 195 3 - - HYPH cord-020235-stcrozdw 195 4 6S 6s JJ cord-020235-stcrozdw 195 5 form form NN cord-020235-stcrozdw 195 6 bound bind VBN cord-020235-stcrozdw 195 7 equally equally RB cord-020235-stcrozdw 195 8 well well RB cord-020235-stcrozdw 195 9 to to IN cord-020235-stcrozdw 195 10 origin origin NN cord-020235-stcrozdw 195 11 DNA dna NN cord-020235-stcrozdw 195 12 in in IN cord-020235-stcrozdw 195 13 the the DT cord-020235-stcrozdw 195 14 presence presence NN cord-020235-stcrozdw 195 15 and and CC cord-020235-stcrozdw 195 16 absence absence NN cord-020235-stcrozdw 195 17 of of IN cord-020235-stcrozdw 195 18 excess excess JJ cord-020235-stcrozdw 195 19 cellul cellul NN cord-020235-stcrozdw 195 20 ar ar NNP cord-020235-stcrozdw 195 21 DNA DNA NNP cord-020235-stcrozdw 195 22 , , , cord-020235-stcrozdw 195 23 whereas whereas IN cord-020235-stcrozdw 195 24 the the DT cord-020235-stcrozdw 195 25 binding binding NN cord-020235-stcrozdw 195 26 of of IN cord-020235-stcrozdw 195 27 the the DT cord-020235-stcrozdw 195 28 14 14 CD cord-020235-stcrozdw 195 29 - - HYPH cord-020235-stcrozdw 195 30 16S 16s CD cord-020235-stcrozdw 195 31 form form NN cord-020235-stcrozdw 195 32 was be VBD cord-020235-stcrozdw 195 33 reduced reduce VBN cord-020235-stcrozdw 195 34 in in IN cord-020235-stcrozdw 195 35 the the DT cord-020235-stcrozdw 195 36 presence presence NN cord-020235-stcrozdw 195 37 of of IN cord-020235-stcrozdw 195 38 cellular cellular JJ cord-020235-stcrozdw 195 39 DNA dna NN cord-020235-stcrozdw 195 40 . . . cord-020235-stcrozdw 196 1 All all DT cord-020235-stcrozdw 196 2 forms form NNS cord-020235-stcrozdw 196 3 of of IN cord-020235-stcrozdw 196 4 T T NNP cord-020235-stcrozdw 196 5 antigen antigen NN cord-020235-stcrozdw 196 6 from from IN cord-020235-stcrozdw 196 7 SV40-transformed SV40-transformed NNP cord-020235-stcrozdw 196 8 SV80 SV80 NNP cord-020235-stcrozdw 196 9 cells cell NNS cord-020235-stcrozdw 196 10 bound bind VBN cord-020235-stcrozdw 196 11 much much RB cord-020235-stcrozdw 196 12 less less JJR cord-020235-stcrozdw 196 13 origin origin NN cord-020235-stcrozdw 196 14 DNA dna NN cord-020235-stcrozdw 196 15 than than IN cord-020235-stcrozdw 196 16 that that DT cord-020235-stcrozdw 196 17 from from IN cord-020235-stcrozdw 196 18 infected infected JJ cord-020235-stcrozdw 196 19 cells cell NNS cord-020235-stcrozdw 196 20 . . . cord-020235-stcrozdw 197 1 ( ( -LRB- cord-020235-stcrozdw 197 2 1 1 LS cord-020235-stcrozdw 197 3 ) ) -RRB- cord-020235-stcrozdw 197 4 Fanning Fanning NNP cord-020235-stcrozdw 197 5 , , , cord-020235-stcrozdw 197 6 Nowak Nowak NNP cord-020235-stcrozdw 197 7 , , , cord-020235-stcrozdw 197 8 Burger Burger NNP cord-020235-stcrozdw 197 9 : : : cord-020235-stcrozdw 197 10 J. J. NNP cord-020235-stcrozdw 197 11 Virol37 Virol37 NNP cord-020235-stcrozdw 197 12 ( ( -LRB- cord-020235-stcrozdw 197 13 1981 1981 CD cord-020235-stcrozdw 197 14 ) ) -RRB- cord-020235-stcrozdw 198 1 Wart wart NN cord-020235-stcrozdw 198 2 scrapings scraping NNS cord-020235-stcrozdw 198 3 from from IN cord-020235-stcrozdw 198 4 several several JJ cord-020235-stcrozdw 198 5 small small JJ cord-020235-stcrozdw 198 6 skin skin NN cord-020235-stcrozdw 198 7 regions region NNS cord-020235-stcrozdw 198 8 of of IN cord-020235-stcrozdw 198 9 an an DT cord-020235-stcrozdw 198 10 Epidermodysplasia Epidermodysplasia NNP cord-020235-stcrozdw 198 11 verruciformis verruciformis NN cord-020235-stcrozdw 198 12 patient patient NN cord-020235-stcrozdw 198 13 were be VBD cord-020235-stcrozdw 198 14 tested test VBN cord-020235-stcrozdw 198 15 for for IN cord-020235-stcrozdw 198 16 papilomavirus papilomavirus NNP cord-020235-stcrozdw 198 17 - - HYPH cord-020235-stcrozdw 198 18 specific specific JJ cord-020235-stcrozdw 198 19 sequences sequence NNS cord-020235-stcrozdw 198 20 by by IN cord-020235-stcrozdw 198 21 means mean NNS cord-020235-stcrozdw 198 22 of of IN cord-020235-stcrozdw 198 23 a a DT cord-020235-stcrozdw 198 24 32P 32p CD cord-020235-stcrozdw 198 25 - - HYPH cord-020235-stcrozdw 198 26 labelled label VBN cord-020235-stcrozdw 198 27 HPV8 HPV8 NNP cord-020235-stcrozdw 198 28 DNA dna NN cord-020235-stcrozdw 198 29 . . . cord-020235-stcrozdw 199 1 Uncleaved uncleaved JJ cord-020235-stcrozdw 199 2 wart wart NN cord-020235-stcrozdw 199 3 DNA DNA NNP cord-020235-stcrozdw 199 4 contained contain VBD cord-020235-stcrozdw 199 5 uniforme uniforme NNP cord-020235-stcrozdw 199 6 full full JJ cord-020235-stcrozdw 199 7 length length NN cord-020235-stcrozdw 199 8 HPV hpv NN cord-020235-stcrozdw 199 9 genomes genome NNS cord-020235-stcrozdw 199 10 . . . cord-020235-stcrozdw 200 1 Cleavage cleavage NN cord-020235-stcrozdw 200 2 with with IN cord-020235-stcrozdw 200 3 Bam Bam NNP cord-020235-stcrozdw 200 4 HI HI NNP cord-020235-stcrozdw 200 5 revealed reveal VBD cord-020235-stcrozdw 200 6 six six CD cord-020235-stcrozdw 200 7 different different JJ cord-020235-stcrozdw 200 8 patterns pattern NNS cord-020235-stcrozdw 200 9 and and CC cord-020235-stcrozdw 200 10 a a DT cord-020235-stcrozdw 200 11 surprising surprising JJ cord-020235-stcrozdw 200 12 heterogeneity heterogeneity NN cord-020235-stcrozdw 200 13 even even RB cord-020235-stcrozdw 200 14 within within IN cord-020235-stcrozdw 200 15 small small JJ cord-020235-stcrozdw 200 16 biopsies biopsy NNS cord-020235-stcrozdw 200 17 . . . cord-020235-stcrozdw 201 1 At at RB cord-020235-stcrozdw 201 2 least least RBS cord-020235-stcrozdw 201 3 two two CD cord-020235-stcrozdw 201 4 virus virus NN cord-020235-stcrozdw 201 5 types type NNS cord-020235-stcrozdw 201 6 showed show VBD cord-020235-stcrozdw 201 7 only only RB cord-020235-stcrozdw 201 8 limited limited JJ cord-020235-stcrozdw 201 9 cross cross NN cord-020235-stcrozdw 201 10 - - NN cord-020235-stcrozdw 201 11 hybridization hybridization NN cord-020235-stcrozdw 201 12 with with IN cord-020235-stcrozdw 201 13 HPV HPV NNP cord-020235-stcrozdw 201 14 8a 8a NN cord-020235-stcrozdw 201 15 . . . cord-020235-stcrozdw 202 1 One one CD cord-020235-stcrozdw 202 2 of of IN cord-020235-stcrozdw 202 3 these these DT cord-020235-stcrozdw 202 4 closely closely RB cord-020235-stcrozdw 202 5 resembles resemble VBZ cord-020235-stcrozdw 202 6 HPV HPV NNP cord-020235-stcrozdw 202 7 5b 5b NN cord-020235-stcrozdw 202 8 ( ( -LRB- cord-020235-stcrozdw 202 9 Bam Bam NNP cord-020235-stcrozdw 202 10 HI HI NNP cord-020235-stcrozdw 202 11 fragments fragment NNS cord-020235-stcrozdw 202 12 2,9 2,9 CD cord-020235-stcrozdw 202 13 and and CC cord-020235-stcrozdw 202 14 2,1 2,1 CD cord-020235-stcrozdw 203 1 ; ; : cord-020235-stcrozdw 203 2 Eco eco JJ cord-020235-stcrozdw 203 3 RI RI NNP cord-020235-stcrozdw 203 4 fragments fragment NNS cord-020235-stcrozdw 203 5 3,6 3,6 CD cord-020235-stcrozdw 203 6 and and CC cord-020235-stcrozdw 203 7 1,1 1,1 CD cord-020235-stcrozdw 203 8 ) ) -RRB- cord-020235-stcrozdw 203 9 . . . cord-020235-stcrozdw 204 1 Hind Hind NNP cord-020235-stcrozdw 204 2 II ii CD cord-020235-stcrozdw 204 3 fragments fragment NNS cord-020235-stcrozdw 205 1 A a NN cord-020235-stcrozdw 205 2 and and CC cord-020235-stcrozdw 205 3 C c NN cord-020235-stcrozdw 205 4 of of IN cord-020235-stcrozdw 205 5 his -PRON- PRP$ cord-020235-stcrozdw 205 6 virus virus NN cord-020235-stcrozdw 205 7 perfectly perfectly RB cord-020235-stcrozdw 205 8 hybridize hybridize VBP cord-020235-stcrozdw 205 9 with with IN cord-020235-stcrozdw 205 10 HPV hpv NN cord-020235-stcrozdw 205 11 8a 8a NN cord-020235-stcrozdw 205 12 ; ; : cord-020235-stcrozdw 205 13 B b NN cord-020235-stcrozdw 205 14 , , , cord-020235-stcrozdw 205 15 D d NN cord-020235-stcrozdw 205 16 and and CC cord-020235-stcrozdw 205 17 6 6 CD cord-020235-stcrozdw 205 18 anneal anneal NN cord-020235-stcrozdw 206 1 only only RB cord-020235-stcrozdw 206 2 partially partially RB cord-020235-stcrozdw 206 3 and and CC cord-020235-stcrozdw 206 4 F F NNP cord-020235-stcrozdw 206 5 , , , cord-020235-stcrozdw 206 6 G G NNP cord-020235-stcrozdw 206 7 show show VBP cord-020235-stcrozdw 206 8 no no DT cord-020235-stcrozdw 206 9 detectable detectable JJ cord-020235-stcrozdw 206 10 hybridization hybridization NN cord-020235-stcrozdw 206 11 . . . cord-020235-stcrozdw 207 1 The the DT cord-020235-stcrozdw 207 2 DNAs dna NNS cord-020235-stcrozdw 207 3 of of IN cord-020235-stcrozdw 207 4 four four CD cord-020235-stcrozdw 207 5 subtypes subtype NNS cord-020235-stcrozdw 207 6 were be VBD cord-020235-stcrozdw 207 7 partially partially RB cord-020235-stcrozdw 207 8 characterized characterize VBN cord-020235-stcrozdw 207 9 and and CC cord-020235-stcrozdw 207 10 mapped map VBN cord-020235-stcrozdw 207 11 . . . cord-020235-stcrozdw 208 1 Only only RB cord-020235-stcrozdw 208 2 DNA DNA NNP cord-020235-stcrozdw 208 3 of of IN cord-020235-stcrozdw 208 4 the the DT cord-020235-stcrozdw 208 5 HPV HPV NNP cord-020235-stcrozdw 208 6 5b 5b NN cord-020235-stcrozdw 208 7 - - HYPH cord-020235-stcrozdw 208 8 like like JJ cord-020235-stcrozdw 208 9 virus virus NN cord-020235-stcrozdw 208 10 was be VBD cord-020235-stcrozdw 208 11 detected detect VBN cord-020235-stcrozdw 208 12 in in IN cord-020235-stcrozdw 208 13 a a DT cord-020235-stcrozdw 208 14 probe probe NN cord-020235-stcrozdw 208 15 from from IN cord-020235-stcrozdw 208 16 the the DT cord-020235-stcrozdw 208 17 center center NN cord-020235-stcrozdw 208 18 of of IN cord-020235-stcrozdw 208 19 a a DT cord-020235-stcrozdw 208 20 carcinoma carcinoma NN cord-020235-stcrozdw 208 21 at at IN cord-020235-stcrozdw 208 22 the the DT cord-020235-stcrozdw 208 23 patient patient NN cord-020235-stcrozdw 208 24 's 's POS cord-020235-stcrozdw 208 25 forehead forehead NN cord-020235-stcrozdw 208 26 . . . cord-020235-stcrozdw 209 1 This this DT cord-020235-stcrozdw 209 2 DNA dna NN cord-020235-stcrozdw 209 3 persists persist VBZ cord-020235-stcrozdw 209 4 extrachromosomally extrachromosomally RB cord-020235-stcrozdw 209 5 with with IN cord-020235-stcrozdw 209 6 more more JJR cord-020235-stcrozdw 209 7 than than IN cord-020235-stcrozdw 209 8 100 100 CD cord-020235-stcrozdw 209 9 genome genome NN cord-020235-stcrozdw 209 10 equivalents equivalent NNS cord-020235-stcrozdw 209 11 per per IN cord-020235-stcrozdw 209 12 cell cell NN cord-020235-stcrozdw 209 13 . . . cord-020235-stcrozdw 210 1 Inst Inst NNP cord-020235-stcrozdw 210 2 , , , cord-020235-stcrozdw 210 3 f. f. NN cord-020235-stcrozdw 210 4 Virologie Virologie NNP cord-020235-stcrozdw 210 5 , , , cord-020235-stcrozdw 210 6 Zentrum Zentrum NNP cord-020235-stcrozdw 210 7 Hygiene Hygiene NNP cord-020235-stcrozdw 210 8 , , , cord-020235-stcrozdw 210 9 Univ Univ NNP cord-020235-stcrozdw 210 10 . . NNP cord-020235-stcrozdw 210 11 , , , cord-020235-stcrozdw 210 12 Hermann Hermann NNP cord-020235-stcrozdw 210 13 - - HYPH cord-020235-stcrozdw 210 14 Herder Herder NNP cord-020235-stcrozdw 210 15 - - HYPH cord-020235-stcrozdw 210 16 Str Str NNP cord-020235-stcrozdw 210 17 . . . cord-020235-stcrozdw 211 1 11 11 CD cord-020235-stcrozdw 211 2 , , , cord-020235-stcrozdw 211 3 D-7800 d-7800 CD cord-020235-stcrozdw 211 4 Freiburg Freiburg NNP cord-020235-stcrozdw 211 5 Gene Gene NNP cord-020235-stcrozdw 211 6 Expression Expression NNP cord-020235-stcrozdw 211 7 of of IN cord-020235-stcrozdw 211 8 Papillomaviruses Papillomaviruses NNP cord-020235-stcrozdw 211 9 in in IN cord-020235-stcrozdw 211 10 Hamster Hamster NNP cord-020235-stcrozdw 211 11 Tumors tumor NNS cord-020235-stcrozdw 211 12 FREESE FREESE NNP cord-020235-stcrozdw 211 13 , , , cord-020235-stcrozdw 211 14 U. U. NNP cord-020235-stcrozdw 211 15 K.,SCHULTE K.,SCHULTE NNP cord-020235-stcrozdw 211 16 , , , cord-020235-stcrozdw 211 17 P. P. NNP cord-020235-stcrozdw 211 18 , , , cord-020235-stcrozdw 211 19 and and CC cord-020235-stcrozdw 211 20 PFISTER PFISTER NNP cord-020235-stcrozdw 211 21 , , , cord-020235-stcrozdw 211 22 H. H. NNP cord-020235-stcrozdw 211 23 BPV BPV NNP cord-020235-stcrozdw 211 24 1 1 CD cord-020235-stcrozdw 211 25 includes include VBZ cord-020235-stcrozdw 211 26 fibrosarcomas fibrosarcomas NNP cord-020235-stcrozdw 211 27 in in IN cord-020235-stcrozdw 211 28 hamsters hamster NNS cord-020235-stcrozdw 211 29 . . . cord-020235-stcrozdw 212 1 The the DT cord-020235-stcrozdw 212 2 tumors tumor NNS cord-020235-stcrozdw 212 3 contain contain VBP cord-020235-stcrozdw 212 4 large large JJ cord-020235-stcrozdw 212 5 amounts amount NNS cord-020235-stcrozdw 212 6 of of IN cord-020235-stcrozdw 212 7 complete complete JJ cord-020235-stcrozdw 212 8 virus virus NN cord-020235-stcrozdw 212 9 genomes genome NNS cord-020235-stcrozdw 212 10 which which WDT cord-020235-stcrozdw 212 11 persist persist VBP cord-020235-stcrozdw 212 12 extrachromosomally extrachromosomally RB cord-020235-stcrozdw 212 13 but but CC cord-020235-stcrozdw 212 14 there there EX cord-020235-stcrozdw 212 15 is be VBZ cord-020235-stcrozdw 212 16 no no DT cord-020235-stcrozdw 212 17 evidence evidence NN cord-020235-stcrozdw 212 18 for for IN cord-020235-stcrozdw 212 19 capsid capsid NN cord-020235-stcrozdw 212 20 protein protein NN cord-020235-stcrozdw 212 21 synthesis synthesis NN cord-020235-stcrozdw 212 22 or or CC cord-020235-stcrozdw 212 23 virus virus NN cord-020235-stcrozdw 212 24 particle particle NN cord-020235-stcrozdw 212 25 production production NN cord-020235-stcrozdw 212 26 . . . cord-020235-stcrozdw 213 1 We -PRON- PRP cord-020235-stcrozdw 213 2 used use VBD cord-020235-stcrozdw 213 3 this this DT cord-020235-stcrozdw 213 4 system system NN cord-020235-stcrozdw 213 5 to to TO cord-020235-stcrozdw 213 6 study study VB cord-020235-stcrozdw 213 7 early early JJ cord-020235-stcrozdw 213 8 viral viral JJ cord-020235-stcrozdw 213 9 gene gene NN cord-020235-stcrozdw 213 10 expression expression NN cord-020235-stcrozdw 213 11 . . . cord-020235-stcrozdw 214 1 RNA RNA NNP cord-020235-stcrozdw 214 2 from from IN cord-020235-stcrozdw 214 3 the the DT cord-020235-stcrozdw 214 4 tumors tumor NNS cord-020235-stcrozdw 214 5 contained contain VBD cord-020235-stcrozdw 214 6 a a DT cord-020235-stcrozdw 214 7 single single JJ cord-020235-stcrozdw 214 8 virus virus NN cord-020235-stcrozdw 214 9 - - HYPH cord-020235-stcrozdw 214 10 specific specific JJ cord-020235-stcrozdw 214 11 RNA RNA NNP cord-020235-stcrozdw 214 12 with with IN cord-020235-stcrozdw 214 13 about about IN cord-020235-stcrozdw 214 14 1300 1300 CD cord-020235-stcrozdw 214 15 nucleotides nucleotide NNS cord-020235-stcrozdw 214 16 which which WDT cord-020235-stcrozdw 214 17 was be VBD cord-020235-stcrozdw 214 18 shown show VBN cord-020235-stcrozdw 214 19 to to TO cord-020235-stcrozdw 214 20 be be VB cord-020235-stcrozdw 214 21 polyadenylated polyadenylate VBN cord-020235-stcrozdw 214 22 by by IN cord-020235-stcrozdw 214 23 affinity affinity NN cord-020235-stcrozdw 214 24 chromatography chromatography NN cord-020235-stcrozdw 214 25 on on IN cord-020235-stcrozdw 214 26 poly poly NNP cord-020235-stcrozdw 214 27 - - HYPH cord-020235-stcrozdw 214 28 Uesepharose Uesepharose NNP cord-020235-stcrozdw 214 29 . . . cord-020235-stcrozdw 215 1 The the DT cord-020235-stcrozdw 215 2 transcribed transcribe VBN cord-020235-stcrozdw 215 3 DNA dna NN cord-020235-stcrozdw 215 4 region region NN cord-020235-stcrozdw 215 5 of of IN cord-020235-stcrozdw 215 6 BPV BPV NNP cord-020235-stcrozdw 215 7 1 1 CD cord-020235-stcrozdw 215 8 was be VBD cord-020235-stcrozdw 215 9 mapped map VBN cord-020235-stcrozdw 215 10 within within IN cord-020235-stcrozdw 215 11 the the DT cord-020235-stcrozdw 215 12 two two CD cord-020235-stcrozdw 215 13 Hpa Hpa NNP cord-020235-stcrozdw 215 14 II II NNP cord-020235-stcrozdw 215 15 fragments fragment NNS cord-020235-stcrozdw 215 16 , , , cord-020235-stcrozdw 215 17 which which WDT cord-020235-stcrozdw 215 18 are be VBP cord-020235-stcrozdw 215 19 next next JJ cord-020235-stcrozdw 215 20 to to IN cord-020235-stcrozdw 215 21 the the DT cord-020235-stcrozdw 215 22 Bam Bam NNP cord-020235-stcrozdw 215 23 HI HI NNP cord-020235-stcrozdw 215 24 cleavage cleavage NN cord-020235-stcrozdw 215 25 site site NN cord-020235-stcrozdw 215 26 within within IN cord-020235-stcrozdw 215 27 the the DT cord-020235-stcrozdw 215 28 1.4 1.4 CD cord-020235-stcrozdw 215 29 X x SYM cord-020235-stcrozdw 215 30 10 10 CD cord-020235-stcrozdw 215 31 6 6 CD cord-020235-stcrozdw 215 32 d d NN cord-020235-stcrozdw 215 33 Bam Bam NNP cord-020235-stcrozdw 215 34 HIIEco hiieco JJ cord-020235-stcrozdw 215 35 RI RI NNP cord-020235-stcrozdw 215 36 fragment fragment NN cord-020235-stcrozdw 215 37 . . . cord-020235-stcrozdw 216 1 Cross cross NN cord-020235-stcrozdw 216 2 - - NN cord-020235-stcrozdw 216 3 hybridization hybridization JJ cord-020235-stcrozdw 216 4 studies study NNS cord-020235-stcrozdw 216 5 under under IN cord-020235-stcrozdw 216 6 low low JJ cord-020235-stcrozdw 216 7 stringency stringency NN cord-020235-stcrozdw 216 8 revealed reveal VBD cord-020235-stcrozdw 216 9 some some DT cord-020235-stcrozdw 216 10 sequence sequence NN cord-020235-stcrozdw 216 11 relationship relationship NN cord-020235-stcrozdw 216 12 of of IN cord-020235-stcrozdw 216 13 HPV HPV NNP cord-020235-stcrozdw 216 14 1 1 CD cord-020235-stcrozdw 216 15 and and CC cord-020235-stcrozdw 216 16 HPV HPV NNP cord-020235-stcrozdw 216 17 4 4 CD cord-020235-stcrozdw 216 18 DNA dna NN cord-020235-stcrozdw 216 19 to to IN cord-020235-stcrozdw 216 20 the the DT cord-020235-stcrozdw 216 21 transcribed transcribe VBN cord-020235-stcrozdw 216 22 region region NN cord-020235-stcrozdw 216 23 of of IN cord-020235-stcrozdw 216 24 BPV BPV NNP cord-020235-stcrozdw 216 25 1 1 CD cord-020235-stcrozdw 216 26 . . . cord-020235-stcrozdw 217 1 Inst Inst NNP cord-020235-stcrozdw 217 2 . . . cord-020235-stcrozdw 218 1 of of IN cord-020235-stcrozdw 218 2 Genetics Genetics NNP cord-020235-stcrozdw 218 3 , , , cord-020235-stcrozdw 218 4 Univ Univ NNP cord-020235-stcrozdw 218 5 . . NNP cord-020235-stcrozdw 218 6 , , , cord-020235-stcrozdw 218 7 D-5000 D-5000 NNP cord-020235-stcrozdw 219 1 Cologne Cologne NNP cord-020235-stcrozdw 219 2 The the DT cord-020235-stcrozdw 219 3 Adenovirus Adenovirus NNP cord-020235-stcrozdw 219 4 Type Type NNP cord-020235-stcrozdw 219 5 12-Mouse 12-mouse CD cord-020235-stcrozdw 219 6 Cell cell NN cord-020235-stcrozdw 219 7 System system NN cord-020235-stcrozdw 219 8 : : : cord-020235-stcrozdw 219 9 Permissivity Permissivity NNP cord-020235-stcrozdw 219 10 and and CC cord-020235-stcrozdw 219 11 Analysis Analysis NNP cord-020235-stcrozdw 219 12 of of IN cord-020235-stcrozdw 219 13 Viral Viral NNP cord-020235-stcrozdw 219 14 DNA DNA NNP cord-020235-stcrozdw 219 15 in in IN cord-020235-stcrozdw 219 16 Tumor tumor NN cord-020235-stcrozdw 219 17 Cells cell NNS cord-020235-stcrozdw 219 18 STARZINSKI starzinski NN cord-020235-stcrozdw 219 19 - - HYPH cord-020235-stcrozdw 219 20 POWITZ POWITZ NNP cord-020235-stcrozdw 219 21 , , , cord-020235-stcrozdw 219 22 A. A. NNP cord-020235-stcrozdw 219 23 , , , cord-020235-stcrozdw 219 24 SCHULZ SCHULZ NNP cord-020235-stcrozdw 219 25 , , , cord-020235-stcrozdw 219 26 M. M. NNP cord-020235-stcrozdw 219 27 , , , cord-020235-stcrozdw 219 28 and and CC cord-020235-stcrozdw 219 29 DOERFLER DOERFLER NNP cord-020235-stcrozdw 219 30 , , , cord-020235-stcrozdw 219 31 W. W. NNP cord-020235-stcrozdw 219 32 Interactions Interactions NNPS cord-020235-stcrozdw 219 33 between between IN cord-020235-stcrozdw 219 34 viruses virus NNS cord-020235-stcrozdw 219 35 and and CC cord-020235-stcrozdw 219 36 eucaryotic eucaryotic JJ cord-020235-stcrozdw 219 37 cells cell NNS cord-020235-stcrozdw 219 38 can can MD cord-020235-stcrozdw 219 39 be be VB cord-020235-stcrozdw 219 40 studied study VBN cord-020235-stcrozdw 219 41 in in IN cord-020235-stcrozdw 219 42 a a DT cord-020235-stcrozdw 219 43 genetically genetically RB cord-020235-stcrozdw 219 44 well well RB cord-020235-stcrozdw 219 45 defined define VBN cord-020235-stcrozdw 219 46 system system NN cord-020235-stcrozdw 219 47 like like IN cord-020235-stcrozdw 219 48 the the DT cord-020235-stcrozdw 219 49 mouse mouse NN cord-020235-stcrozdw 219 50 system system NN cord-020235-stcrozdw 219 51 . . . cord-020235-stcrozdw 220 1 We -PRON- PRP cord-020235-stcrozdw 220 2 have have VBP cord-020235-stcrozdw 220 3 investigated investigate VBN cord-020235-stcrozdw 220 4 whether whether IN cord-020235-stcrozdw 220 5 Ad ad NN cord-020235-stcrozdw 220 6 12 12 CD cord-020235-stcrozdw 220 7 DNA dna NN cord-020235-stcrozdw 220 8 is be VBZ cord-020235-stcrozdw 220 9 able able JJ cord-020235-stcrozdw 220 10 to to TO cord-020235-stcrozdw 220 11 replicate replicate VB cord-020235-stcrozdw 220 12 in in IN cord-020235-stcrozdw 220 13 primary primary JJ cord-020235-stcrozdw 220 14 mouse mouse NN cord-020235-stcrozdw 220 15 kidney kidney NN cord-020235-stcrozdw 220 16 cells cell NNS cord-020235-stcrozdw 220 17 or or CC cord-020235-stcrozdw 220 18 in in IN cord-020235-stcrozdw 220 19 the the DT cord-020235-stcrozdw 220 20 mouse mouse NN cord-020235-stcrozdw 220 21 cell cell NN cord-020235-stcrozdw 220 22 line line NN cord-020235-stcrozdw 220 23 L929 l929 JJ cord-020235-stcrozdw 220 24 . . . cord-020235-stcrozdw 221 1 It -PRON- PRP cord-020235-stcrozdw 221 2 was be VBD cord-020235-stcrozdw 221 3 shown show VBN cord-020235-stcrozdw 221 4 by by IN cord-020235-stcrozdw 221 5 Southern southern JJ cord-020235-stcrozdw 221 6 blot blot NN cord-020235-stcrozdw 221 7 experiments experiment NNS cord-020235-stcrozdw 221 8 that that WDT cord-020235-stcrozdw 221 9 Ad12 Ad12 NNP cord-020235-stcrozdw 221 10 DNA DNA NNP cord-020235-stcrozdw 221 11 was be VBD cord-020235-stcrozdw 221 12 not not RB cord-020235-stcrozdw 221 13 able able JJ cord-020235-stcrozdw 221 14 to to TO cord-020235-stcrozdw 221 15 replicate replicate VB cord-020235-stcrozdw 221 16 in in IN cord-020235-stcrozdw 221 17 L929 L929 NNP cord-020235-stcrozdw 221 18 cells cell NNS cord-020235-stcrozdw 221 19 , , , cord-020235-stcrozdw 221 20 w w NNP cord-020235-stcrozdw 221 21 hereas hereas NNP cord-020235-stcrozdw 221 22 in in IN cord-020235-stcrozdw 221 23 prima prima FW cord-020235-stcrozdw 221 24 ry ry NNP cord-020235-stcrozdw 221 25 mouse mouse NNP cord-020235-stcrozdw 221 26 kidne kidne NNP cord-020235-stcrozdw 221 27 y y NNP cord-020235-stcrozdw 221 28 cells cell NNS cord-020235-stcrozdw 221 29 of of IN cord-020235-stcrozdw 221 30 ( ( -LRB- cord-020235-stcrozdw 221 31 BALB BALB NNP cord-020235-stcrozdw 221 32 / / SYM cord-020235-stcrozdw 221 33 c c NN cord-020235-stcrozdw 221 34 X X NNP cord-020235-stcrozdw 221 35 CS7 CS7 NNP cord-020235-stcrozdw 221 36 / / SYM cord-020235-stcrozdw 221 37 B16 B16 NNP cord-020235-stcrozdw 221 38 ) ) -RRB- cord-020235-stcrozdw 221 39 Fl Fl NNP cord-020235-stcrozdw 221 40 origin origin NN cord-020235-stcrozdw 221 41 , , , cord-020235-stcrozdw 221 42 viral viral JJ cord-020235-stcrozdw 221 43 DNA DNA NNP cord-020235-stcrozdw 221 44 repl repl NNP cord-020235-stcrozdw 221 45 icated icate VBD cord-020235-stcrozdw 221 46 . . . cord-020235-stcrozdw 222 1 Moreover moreover RB cord-020235-stcrozdw 222 2 , , , cord-020235-stcrozdw 222 3 we -PRON- PRP cord-020235-stcrozdw 222 4 subcutaneously subcutaneously RB cord-020235-stcrozdw 222 5 injected inject VBD cord-020235-stcrozdw 222 6 Ad12 Ad12 NNP cord-020235-stcrozdw 222 7 into into IN cord-020235-stcrozdw 222 8 mice mouse NNS cord-020235-stcrozdw 222 9 of of IN cord-020235-stcrozdw 222 10 various various JJ cord-020235-stcrozdw 222 11 genetic genetic JJ cord-020235-stcrozdw 222 12 origins origin NNS cord-020235-stcrozdw 222 13 . . . cord-020235-stcrozdw 223 1 In in IN cord-020235-stcrozdw 223 2 ab ab NNP cord-020235-stcrozdw 223 3 out out RB cord-020235-stcrozdw 223 4 100 100 CD cord-020235-stcrozdw 223 5 mice mouse NNS cord-020235-stcrozdw 223 6 injected inject VBN cord-020235-stcrozdw 223 7 , , , cord-020235-stcrozdw 223 8 one one CD cord-020235-stcrozdw 223 9 rumor rumor NN cord-020235-stcrozdw 223 10 emerged emerge VBD cord-020235-stcrozdw 223 11 in in IN cord-020235-stcrozdw 223 12 a a DT cord-020235-stcrozdw 223 13 BALBlc BALBlc NNP cord-020235-stcrozdw 223 14 mouse mouse NN cord-020235-stcrozdw 223 15 almost almost RB cord-020235-stcrozdw 223 16 8 8 CD cord-020235-stcrozdw 223 17 months month NNS cord-020235-stcrozdw 223 18 after after IN cord-020235-stcrozdw 223 19 injection injection NN cord-020235-stcrozdw 223 20 . . . cord-020235-stcrozdw 224 1 Restriction restriction NN cord-020235-stcrozdw 224 2 pattern pattern NN cord-020235-stcrozdw 224 3 anal anal JJ cord-020235-stcrozdw 224 4 ysis ysis NN cord-020235-stcrozdw 224 5 of of IN cord-020235-stcrozdw 224 6 the the DT cord-020235-stcrozdw 224 7 rumor rumor NN cord-020235-stcrozdw 224 8 or or CC cord-020235-stcrozdw 224 9 DNA DNA NNP cord-020235-stcrozdw 224 10 indicated indicate VBD cord-020235-stcrozdw 224 11 that that IN cord-020235-stcrozdw 224 12 abou abou NNP cord-020235-stcrozdw 224 13 t t NNP cord-020235-stcrozdw 224 14 2 2 CD cord-020235-stcrozdw 224 15 - - SYM cord-020235-stcrozdw 224 16 3 3 CD cord-020235-stcrozdw 224 17 copies copy NNS cord-020235-stcrozdw 224 18 of of IN cord-020235-stcrozdw 224 19 Ad12 Ad12 NNP cord-020235-stcrozdw 224 20 DN DN NNP cord-020235-stcrozdw 224 21 A A NNP cord-020235-stcrozdw 224 22 were be VBD cord-020235-stcrozdw 224 23 integrated integrate VBN cord-020235-stcrozdw 224 24 and and CC cord-020235-stcrozdw 224 25 covalently covalently RB cord-020235-stcrozdw 224 26 bound bind VBN cord-020235-stcrozdw 224 27 to to IN cord-020235-stcrozdw 224 28 cellular cellular JJ cord-020235-stcrozdw 224 29 DNA dna NN cord-020235-stcrozdw 224 30 . . . cord-020235-stcrozdw 225 1 With with IN cord-020235-stcrozdw 225 2 th th XX cord-020235-stcrozdw 225 3 e e NN cord-020235-stcrozdw 225 4 techniques technique NNS cord-020235-stcrozdw 225 5 available available JJ cord-020235-stcrozdw 225 6 no no DT cord-020235-stcrozdw 225 7 deletion deletion NN cord-020235-stcrozdw 225 8 or or CC cord-020235-stcrozdw 225 9 rearrangement rearrangement NN cord-020235-stcrozdw 225 10 of of IN cord-020235-stcrozdw 225 11 viral viral JJ cord-020235-stcrozdw 225 12 DNA dna NN cord-020235-stcrozdw 225 13 could could MD cord-020235-stcrozdw 225 14 be be VB cord-020235-stcrozdw 225 15 found find VBN cord-020235-stcrozdw 225 16 . . . cord-020235-stcrozdw 226 1 T T NNP cord-020235-stcrozdw 226 2 he -PRON- PRP cord-020235-stcrozdw 226 3 sites site NNS cord-020235-stcrozdw 226 4 of of IN cord-020235-stcrozdw 226 5 jun jun NNP cord-020235-stcrozdw 226 6 ction ction NNP cord-020235-stcrozdw 226 7 betw betw NNP cord-020235-stcrozdw 226 8 een een NNP cord-020235-stcrozdw 226 9 viral viral JJ cord-020235-stcrozdw 226 10 and and CC cord-020235-stcrozdw 226 11 cellular cellular JJ cord-020235-stcrozdw 226 12 DNA dna NN cord-020235-stcrozdw 226 13 will will MD cord-020235-stcrozdw 226 14 now now RB cord-020235-stcrozdw 226 15 be be VB cord-020235-stcrozdw 226 16 cloned clone VBN cord-020235-stcrozdw 226 17 and and CC cord-020235-stcrozdw 226 18 sequenced sequence VBN cord-020235-stcrozdw 226 19 . . . cord-020235-stcrozdw 227 1 Inst Inst NNP cord-020235-stcrozdw 227 2 , , , cord-020235-stcrozdw 227 3 of of IN cord-020235-stcrozdw 227 4 Genetics Genetics NNP cord-020235-stcrozdw 227 5 , , , cord-020235-stcrozdw 227 6 Univ Univ NNP cord-020235-stcrozdw 227 7 . . NNP cord-020235-stcrozdw 227 8 , , , cord-020235-stcrozdw 227 9 0 0 CD cord-020235-stcrozdw 227 10 - - SYM cord-020235-stcrozdw 227 11 5000 5000 CD cord-020235-stcrozdw 227 12 Co Co NNP cord-020235-stcrozdw 227 13 logne logne NNP cord-020235-stcrozdw 227 14 Virus Virus NNP cord-020235-stcrozdw 227 15 - - HYPH cord-020235-stcrozdw 227 16 Cell cell NN cord-020235-stcrozdw 227 17 DNA dna NN cord-020235-stcrozdw 227 18 Recombinants recombinant NNS cord-020235-stcrozdw 227 19 in in IN cord-020235-stcrozdw 227 20 Human Human NNP cord-020235-stcrozdw 227 21 Cells Cells NNPS cord-020235-stcrozdw 227 22 Lytically lytically RB cord-020235-stcrozdw 227 23 Infected infect VBN cord-020235-stcrozdw 227 24 by by IN cord-020235-stcrozdw 227 25 Ad2 ad2 NN cord-020235-stcrozdw 227 26 NEUMANN NEUMANN NNP cord-020235-stcrozdw 227 27 , , , cord-020235-stcrozdw 227 28 R. R. NNP cord-020235-stcrozdw 227 29 , , , cord-020235-stcrozdw 227 30 WEYER WEYER NNP cord-020235-stcrozdw 227 31 , , , cord-020235-stcrozdw 227 32 U. U. NNP cord-020235-stcrozdw 227 33 , , , cord-020235-stcrozdw 227 34 and and CC cord-020235-stcrozdw 227 35 DOERFLER DOERFLER NNP cord-020235-stcrozdw 227 36 , , , cord-020235-stcrozdw 228 1 W. W. NNP cord-020235-stcrozdw 228 2 There there EX cord-020235-stcrozdw 228 3 is be VBZ cord-020235-stcrozdw 228 4 ample ample JJ cord-020235-stcrozdw 228 5 evidence evidence NN cord-020235-stcrozdw 228 6 for for IN cord-020235-stcrozdw 228 7 the the DT cord-020235-stcrozdw 228 8 notion notion NN cord-020235-stcrozdw 228 9 that that IN cord-020235-stcrozdw 228 10 virus virus NN cord-020235-stcrozdw 228 11 - - HYPH cord-020235-stcrozdw 228 12 cell cell NN cord-020235-stcrozdw 228 13 DNA dna NN cord-020235-stcrozdw 228 14 recombinants recombinant NNS cord-020235-stcrozdw 228 15 are be VBP cord-020235-stcrozdw 228 16 formed form VBN cord-020235-stcrozdw 228 17 in in IN cord-020235-stcrozdw 228 18 human human JJ cord-020235-stcrozdw 228 19 cells cell NNS cord-020235-stcrozdw 228 20 productively productively RB cord-020235-stcrozdw 228 21 infected infect VBN cord-020235-stcrozdw 228 22 with with IN cord-020235-stcrozdw 228 23 adenovirus adenovirus NN cord-020235-stcrozdw 228 24 type type NN cord-020235-stcrozdw 228 25 2 2 CD cord-020235-stcrozdw 228 26 ( ( -LRB- cord-020235-stcrozdw 228 27 Ad2 ad2 NN cord-020235-stcrozdw 228 28 ) ) -RRB- cord-020235-stcrozdw 228 29 . . . cord-020235-stcrozdw 229 1 These these DT cord-020235-stcrozdw 229 2 high high JJ cord-020235-stcrozdw 229 3 molecular molecular JJ cord-020235-stcrozdw 229 4 weight weight NN cord-020235-stcrozdw 229 5 forms form NNS cord-020235-stcrozdw 229 6 were be VBD cord-020235-stcrozdw 229 7 detected detect VBN cord-020235-stcrozdw 229 8 at at IN cord-020235-stcrozdw 229 9 1 1 CD cord-020235-stcrozdw 229 10 - - SYM cord-020235-stcrozdw 229 11 2 2 CD cord-020235-stcrozdw 229 12 h h NN cord-020235-stcrozdw 229 13 postinfection postinfection NN cord-020235-stcrozdw 229 14 and and CC cord-020235-stcrozdw 229 15 were be VBD cord-020235-stcrozdw 229 16 generated generate VBN cord-020235-stcrozdw 229 17 at at IN cord-020235-stcrozdw 229 18 high high JJ cord-020235-stcrozdw 229 19 frequency frequency NN cord-020235-stcrozdw 229 20 , , , cord-020235-stcrozdw 229 21 A a DT cord-020235-stcrozdw 229 22 limited limited JJ cord-020235-stcrozdw 229 23 set set NN cord-020235-stcrozdw 229 24 of of IN cord-020235-stcrozdw 229 25 rather rather RB cord-020235-stcrozdw 229 26 specific specific JJ cord-020235-stcrozdw 229 27 recombinants recombinant NNS cord-020235-stcrozdw 229 28 was be VBD cord-020235-stcrozdw 229 29 produced produce VBN cord-020235-stcrozdw 229 30 ( ( -LRB- cord-020235-stcrozdw 229 31 Neumann Neumann NNP cord-020235-stcrozdw 229 32 and and CC cord-020235-stcrozdw 229 33 Doerfler Doerfler NNP cord-020235-stcrozdw 229 34 , , , cord-020235-stcrozdw 229 35 J. J. NNP cord-020235-stcrozdw 229 36 Virol Virol NNP cord-020235-stcrozdw 229 37 . . . cord-020235-stcrozdw 230 1 ( ( -LRB- cord-020235-stcrozdw 230 2 1981 1981 CD cord-020235-stcrozdw 230 3 ) ) -RRB- cord-020235-stcrozdw 230 4 887 887 CD cord-020235-stcrozdw 230 5 suggesting suggest VBG cord-020235-stcrozdw 230 6 th th XX cord-020235-stcrozdw 230 7 at at IN cord-020235-stcrozdw 230 8 recomb recomb NN cord-020235-stcrozdw 230 9 ination ination NN cord-020235-stcrozdw 230 10 exhibited exhibit VBD cord-020235-stcrozdw 230 11 a a DT cord-020235-stcrozdw 230 12 cert cert NN cord-020235-stcrozdw 230 13 ain ain NNP cord-020235-stcrozdw 230 14 specificity specificity NN cord-020235-stcrozdw 230 15 . . . cord-020235-stcrozdw 231 1 We -PRON- PRP cord-020235-stcrozdw 231 2 now now RB cord-020235-stcrozdw 231 3 succeeded succeed VBD cord-020235-stcrozdw 231 4 in in IN cord-020235-stcrozdw 231 5 molecularly molecularly RB cord-020235-stcrozdw 231 6 cloning clone VBG cord-020235-stcrozdw 231 7 DNA dna NN cord-020235-stcrozdw 231 8 frag frag NN cord-020235-stcrozdw 231 9 ments ment NNS cord-020235-stcrozdw 231 10 excised excise VBN cord-020235-stcrozdw 231 11 from from IN cord-020235-stcrozdw 231 12 the the DT cord-020235-stcrozdw 231 13 high high JJ cord-020235-stcrozdw 231 14 mole mole NN cord-020235-stcrozdw 231 15 cular cular JJ cord-020235-stcrozdw 231 16 weight weight NN cord-020235-stcrozdw 231 17 DN DN NNP cord-020235-stcrozdw 231 18 A A NNP cord-020235-stcrozdw 231 19 of of IN cord-020235-stcrozdw 231 20 Ad2-infected Ad2-infected NNP cord-020235-stcrozdw 231 21 hum hum VBP cord-020235-stcrozdw 231 22 an an DT cord-020235-stcrozdw 231 23 cells cell NNS cord-020235-stcrozdw 231 24 by by IN cord-020235-stcrozdw 231 25 th th XX cord-020235-stcrozdw 231 26 e e NN cord-020235-stcrozdw 231 27 restri restri NNP cord-020235-stcrozdw 231 28 ction ction NN cord-020235-stcrozdw 231 29 endonuclease endonuclease NNP cord-020235-stcrozdw 231 30 EcoRI EcoRI NNP cord-020235-stcrozdw 231 31 in in IN cord-020235-stcrozdw 231 32 AgtWES agtwe NNS cord-020235-stcrozdw 231 33 . . . cord-020235-stcrozdw 231 34 AB AB NNP cord-020235-stcrozdw 231 35 or or CC cord-020235-stcrozdw 231 36 in in IN cord-020235-stcrozdw 231 37 ACharon ACharon NNP cord-020235-stcrozdw 231 38 4B. 4b. CD cord-020235-stcrozdw 232 1 Some some DT cord-020235-stcrozdw 232 2 of of IN cord-020235-stcrozdw 232 3 these these DT cord-020235-stcrozdw 232 4 clon clon NN cord-020235-stcrozdw 232 5 ed ed NN cord-020235-stcrozdw 232 6 frag frag NN cord-020235-stcrozdw 232 7 ments ment NNS cord-020235-stcrozdw 232 8 had have VBD cord-020235-stcrozdw 232 9 sequence sequence NN cord-020235-stcrozdw 232 10 ho ho NN cord-020235-stcrozdw 232 11 mology mology NN cord-020235-stcrozdw 232 12 to to IN cord-020235-stcrozdw 232 13 both both CC cord-020235-stcrozdw 232 14 viral viral JJ cord-020235-stcrozdw 232 15 and and CC cord-020235-stcrozdw 232 16 cellular cellular JJ cord-020235-stcrozdw 232 17 D d NN cord-020235-stcrozdw 232 18 NA na NN cord-020235-stcrozdw 232 19 . . . cord-020235-stcrozdw 233 1 Th th JJ cord-020235-stcrozdw 233 2 is be VBZ cord-020235-stcrozdw 233 3 result result NN cord-020235-stcrozdw 233 4 provided provide VBN cord-020235-stcrozdw 233 5 proof proof NN cord-020235-stcrozdw 233 6 fo fo IN cord-020235-stcrozdw 233 7 r r NN cord-020235-stcrozdw 233 8 the the DT cord-020235-stcrozdw 233 9 occurrence occurrence NN cord-020235-stcrozdw 233 10 of of IN cord-020235-stcrozdw 233 11 virus virus NN cord-020235-stcrozdw 233 12 - - HYPH cord-020235-stcrozdw 233 13 cell cell NN cord-020235-stcrozdw 233 14 DNA dna NN cord-020235-stcrozdw 233 15 recombi recombi NN cord-020235-stcrozdw 233 16 na na IN cord-020235-stcrozdw 233 17 nts nt NNS cord-020235-stcrozdw 233 18 . . . cord-020235-stcrozdw 234 1 Inst Inst NNP cord-020235-stcrozdw 234 2 , , , cord-020235-stcrozdw 234 3 of of IN cord-020235-stcrozdw 234 4 Genetics Genetics NNP cord-020235-stcrozdw 234 5 , , , cord-020235-stcrozdw 234 6 Univ Univ NNP cord-020235-stcrozdw 234 7 . . NNP cord-020235-stcrozdw 234 8 , , , cord-020235-stcrozdw 234 9 0 0 CD cord-020235-stcrozdw 234 10 - - SYM cord-020235-stcrozdw 234 11 5000 5000 CD cord-020235-stcrozdw 234 12 Cologne Cologne NNP cord-020235-stcrozdw 234 13 Unmethylated Unmethylated NNP cord-020235-stcrozdw 234 14 DNA DNA NNP cord-020235-stcrozdw 234 15 Sequences Sequences NNPS cord-020235-stcrozdw 234 16 in in IN cord-020235-stcrozdw 234 17 the the DT cord-020235-stcrozdw 234 18 Promoter Promoter NNP cord-020235-stcrozdw 234 19 Regions Regions NNPS cord-020235-stcrozdw 234 20 of of IN cord-020235-stcrozdw 234 21 Integrated Integrated NNP cord-020235-stcrozdw 234 22 Adenovirus Adenovirus NNP cord-020235-stcrozdw 234 23 Genes Genes NNPS cord-020235-stcrozdw 234 24 Correlate correlate VBP cord-020235-stcrozdw 234 25 with with IN cord-020235-stcrozdw 234 26 Gene Gene NNP cord-020235-stcrozdw 234 27 Expression Expression NNP cord-020235-stcrozdw 234 28 KRUCZEK KRUCZEK NNP cord-020235-stcrozdw 234 29 , , , cord-020235-stcrozdw 234 30 1 1 CD cord-020235-stcrozdw 234 31 . . . cord-020235-stcrozdw 235 1 and and CC cord-020235-stcrozdw 235 2 DOERFLER DOERFLER NNP cord-020235-stcrozdw 235 3 , , , cord-020235-stcrozdw 235 4 W. W. NNP cord-020235-stcrozdw 235 5 An an DT cord-020235-stcrozdw 235 6 inverse inverse JJ cord-020235-stcrozdw 235 7 correlation correlation NN cord-020235-stcrozdw 235 8 was be VBD cord-020235-stcrozdw 235 9 established establish VBN cord-020235-stcrozdw 235 10 between between IN cord-020235-stcrozdw 235 11 the the DT cord-020235-stcrozdw 235 12 levels level NNS cord-020235-stcrozdw 235 13 of of IN cord-020235-stcrozdw 235 14 DN DN NNP cord-020235-stcrozdw 235 15 A A NNP cord-020235-stcrozdw 235 16 met meet VBD cord-020235-stcrozdw 235 17 hylation hylation NN cord-020235-stcrozdw 235 18 at at IN cord-020235-stcrozdw 235 19 5'-CCG 5'-ccg CD cord-020235-stcrozdw 235 20 G-3 G-3 NNP cord-020235-stcrozdw 235 21 ' ' POS cord-020235-stcrozdw 235 22 sites site NNS cord-020235-stcrozdw 235 23 in in IN cord-020235-stcrozdw 235 24 specific specific JJ cord-020235-stcrozdw 235 25 segments segment NNS cord-020235-stcrozdw 235 26 of of IN cord-020235-stcrozdw 235 27 integrated integrate VBN cord-020235-stcrozdw 235 28 adenovirus adenovirus NN cord-020235-stcrozdw 235 29 DNA dna NN cord-020235-stcrozdw 235 30 and and CC cord-020235-stcrozdw 235 31 the the DT cord-020235-stcrozdw 235 32 extent extent NN cord-020235-stcrozdw 235 33 to to IN cord-020235-stcrozdw 235 34 wh wh XX cord-020235-stcrozdw 235 35 ich ich NNP cord-020235-stcrozdw 235 36 the the DT cord-020235-stcrozdw 235 37 se se FW cord-020235-stcrozdw 235 38 segments segment NNS cord-020235-stcrozdw 235 39 were be VBD cord-020235-stcrozdw 235 40 expressed express VBN cord-020235-stcrozdw 235 41 ( ( -LRB- cord-020235-stcrozdw 235 42 Sutt Sutt NNP cord-020235-stcrozdw 235 43 er er UH cord-020235-stcrozdw 235 44 and and CC cord-020235-stcrozdw 235 45 Doerfler Doerfler NNP cord-020235-stcrozdw 235 46 , , , cord-020235-stcrozdw 235 47 PNAS PNAS NNP cord-020235-stcrozdw 235 48 77 77 CD cord-020235-stcrozdw 235 49 ( ( -LRB- cord-020235-stcrozdw 235 50 1980 1980 CD cord-020235-stcrozdw 235 51 ) ) -RRB- cord-020235-stcrozdw 235 52 253 253 CD cord-020235-stcrozdw 235 53 . . . cord-020235-stcrozdw 236 1 Similar similar JJ cord-020235-stcrozdw 236 2 correlatio correlatio NN cord-020235-stcrozdw 236 3 ns ns XX cord-020235-stcrozdw 236 4 were be VBD cord-020235-stcrozdw 236 5 reported report VBN cord-020235-stcrozdw 236 6 in in IN cord-020235-stcrozdw 236 7 other other JJ cord-020235-stcrozdw 236 8 viral viral JJ cord-020235-stcrozdw 236 9 and and CC cord-020235-stcrozdw 236 10 non non JJ cord-020235-stcrozdw 236 11 - - JJ cord-020235-stcrozdw 236 12 viral viral JJ cord-020235-stcrozdw 236 13 systems system NNS cord-020235-stcrozdw 236 14 . . . cord-020235-stcrozdw 237 1 More more RBR cord-020235-stcrozdw 237 2 recently recently RB cord-020235-stcrozdw 237 3 , , , cord-020235-stcrozdw 237 4 the the DT cord-020235-stcrozdw 237 5 results result NNS cord-020235-stcrozdw 237 6 of of IN cord-020235-stcrozdw 237 7 in in FW cord-020235-stcrozdw 237 8 vitro vitro FW cord-020235-stcrozdw 237 9 experiments experiment NNS cord-020235-stcrozdw 237 10 prov prov NNP cord-020235-stcrozdw 237 11 ided ided NNP cord-020235-stcrozdw 237 12 direct direct JJ cord-020235-stcrozdw 237 13 evidence evidence NN cord-020235-stcrozdw 237 14 for for IN cord-020235-stcrozdw 237 15 the the DT cord-020235-stcrozdw 237 16 notion notion NN cord-020235-stcrozdw 237 17 th th XX cord-020235-stcrozdw 237 18 at at IN cord-020235-stcrozdw 237 19 DNA dna NN cord-020235-stcrozdw 237 20 methylation methylation NN cord-020235-stcrozdw 237 21 at at IN cord-020235-stcrozdw 237 22 specific specific JJ cord-020235-stcrozdw 237 23 sites site NNS cord-020235-stcrozdw 237 24 led lead VBN cord-020235-stcrozdw 237 25 to to IN cord-020235-stcrozdw 237 26 gene gene NN cord-020235-stcrozdw 237 27 inactivation inactivation NN cord-020235-stcrozdw 237 28 ( ( -LRB- cord-020235-stcrozdw 237 29 Vardimon Vardimon NNP cord-020235-stcrozdw 237 30 et et NNP cord-020235-stcrozdw 237 31 al al NNP cord-020235-stcrozdw 237 32 . . NNP cord-020235-stcrozdw 237 33 , , , cord-020235-stcrozdw 237 34 PNAS PNAS NNP cord-020235-stcrozdw 237 35 , , , cord-020235-stcrozdw 237 36 in in IN cord-020235-stcrozdw 237 37 press press NN cord-020235-stcrozdw 237 38 ) ) -RRB- cord-020235-stcrozdw 237 39 . . . cord-020235-stcrozdw 238 1 -In -In . cord-020235-stcrozdw 239 1 the the DT cord-020235-stcrozdw 239 2 present present JJ cord-020235-stcrozdw 239 3 stud stud NN cord-020235-stcrozdw 240 1 y y NNP cord-020235-stcrozdw 240 2 a a DT cord-020235-stcrozdw 240 3 detai detai NN cord-020235-stcrozdw 240 4 led lead VBN cord-020235-stcrozdw 240 5 methylation methylation NN cord-020235-stcrozdw 240 6 map map NN cord-020235-stcrozdw 240 7 at at IN cord-020235-stcrozdw 241 1 5'-CC 5'-cc CD cord-020235-stcrozdw 241 2 GG-3 GG-3 NNP cord-020235-stcrozdw 241 3 ' ' '' cord-020235-stcrozdw 241 4 ( ( -LRB- cord-020235-stcrozdw 241 5 H h NN cord-020235-stcrozdw 241 6 paIIlM paiilm RB cord-020235-stcrozdw 241 7 spI spI NNP cord-020235-stcrozdw 241 8 ) ) -RRB- cord-020235-stcrozdw 241 9 sites site NNS cord-020235-stcrozdw 241 10 in in IN cord-020235-stcrozdw 241 11 the the DT cord-020235-stcrozdw 241 12 expressed express VBN cord-020235-stcrozdw 241 13 early early JJ cord-020235-stcrozdw 241 14 and and CC cord-020235-stcrozdw 241 15 the the DT cord-020235-stcrozdw 241 16 silent silent JJ cord-020235-stcrozdw 241 17 late late JJ cord-020235-stcrozdw 241 18 genes gene NNS cord-020235-stcrozdw 241 19 of of IN cord-020235-stcrozdw 241 20 Ad12 Ad12 NNP cord-020235-stcrozdw 241 21 DN DN NNP cord-020235-stcrozdw 241 22 A A NNP cord-020235-stcrozdw 241 23 was be VBD cord-020235-stcrozdw 241 24 determined determine VBN cord-020235-stcrozdw 241 25 in in IN cord-020235-stcrozdw 241 26 three three CD cord-020235-stcrozdw 241 27 Adl2-tr adl2-tr CD cord-020235-stcrozdw 241 28 ansformed ansforme VBN cord-020235-stcrozdw 241 29 hamster hamster NN cord-020235-stcrozdw 241 30 cell cell NN cord-020235-stcrozdw 241 31 lines line NNS cord-020235-stcrozdw 241 32 . . . cord-020235-stcrozdw 242 1 The the DT cord-020235-stcrozdw 242 2 early early JJ cord-020235-stcrozdw 242 3 region region NN cord-020235-stcrozdw 242 4 s s NN cord-020235-stcrozdw 242 5 of of IN cord-020235-stcrozdw 242 6 inte inte NNP cord-020235-stcrozdw 242 7 grated grate VBN cord-020235-stcrozdw 242 8 Ad12 Ad12 NNP cord-020235-stcrozdw 242 9 DNA DNA NNP cord-020235-stcrozdw 242 10 were be VBD cord-020235-stcrozdw 242 11 unmethylated unmethylate VBN cord-020235-stcrozdw 242 12 ; ; : cord-020235-stcrozdw 242 13 in in IN cord-020235-stcrozdw 242 14 particular particular JJ cord-020235-stcrozdw 242 15 their -PRON- PRP$ cord-020235-stcrozdw 242 16 promot promot NN cord-020235-stcrozdw 242 17 er er UH cord-020235-stcrozdw 242 18 regions region NNS cord-020235-stcrozdw 242 19 were be VBD cord-020235-stcrozdw 242 20 unrnethylated unrnethylate VBN cord-020235-stcrozdw 242 21 ar ar NNP cord-020235-stcrozdw 243 1 the the DT cord-020235-stcrozdw 243 2 Hpall Hpall NNP cord-020235-stcrozdw 243 3 sites site NNS cord-020235-stcrozdw 243 4 in in IN cord-020235-stcrozdw 243 5 all all DT cord-020235-stcrozdw 243 6 three three CD cord-020235-stcrozdw 243 7 lines line NNS cord-020235-stcrozdw 243 8 investigated investigate VBN cord-020235-stcrozdw 243 9 . . . cord-020235-stcrozdw 244 1 T T NNP cord-020235-stcrozdw 244 2 he -PRON- PRP cord-020235-stcrozdw 244 3 late late RB cord-020235-stcrozdw 244 4 regio regio NNP cord-020235-stcrozdw 244 5 ns ns IN cord-020235-stcrozdw 244 6 including include VBG cord-020235-stcrozdw 244 7 the the DT cord-020235-stcrozdw 244 8 promot promot NNP cord-020235-stcrozdw 244 9 er er UH cord-020235-stcrozdw 244 10 sites site NNS cord-020235-stcrozdw 244 11 were be VBD cord-020235-stcrozdw 244 12 completely completely RB cord-020235-stcrozdw 244 13 meth meth JJ cord-020235-stcrozdw 244 14 ylated ylated JJ cord-020235-stcrozdw 244 15 . . . cord-020235-stcrozdw 245 1 GAHLMANN GAHLMANN NNP cord-020235-stcrozdw 245 2 , , , cord-020235-stcrozdw 245 3 R. R. NNP cord-020235-stcrozdw 245 4 , , , cord-020235-stcrozdw 245 5 DEURING DEURING NNP cord-020235-stcrozdw 245 6 , , , cord-020235-stcrozdw 245 7 R. R. NNP cord-020235-stcrozdw 245 8 , , , cord-020235-stcrozdw 245 9 STABEL STABEL NNP cord-020235-stcrozdw 245 10 , , , cord-020235-stcrozdw 245 11 S. S. NNP cord-020235-stcrozdw 245 12 , , , cord-020235-stcrozdw 245 13 WINTERHOFF WINTERHOFF NNP cord-020235-stcrozdw 245 14 , , , cord-020235-stcrozdw 245 15 U. U. NNP cord-020235-stcrozdw 245 16 VARDIMON,1 VARDIMON,1 NNS cord-020235-stcrozdw 245 17 . . . cord-020235-stcrozdw 246 1 , , , cord-020235-stcrozdw 246 2 and and CC cord-020235-stcrozdw 246 3 DOERFLER DOERFLER NNP cord-020235-stcrozdw 246 4 , , , cord-020235-stcrozdw 246 5 W. W. NNP cord-020235-stcrozdw 247 1 The the DT cord-020235-stcrozdw 247 2 sites site NNS cord-020235-stcrozdw 247 3 of of IN cord-020235-stcrozdw 247 4 junction junction NN cord-020235-stcrozdw 247 5 between between IN cord-020235-stcrozdw 247 6 viral viral JJ cord-020235-stcrozdw 247 7 and and CC cord-020235-stcrozdw 247 8 cellular cellular JJ cord-020235-stcrozdw 247 9 DNA dna NN cord-020235-stcrozdw 247 10 were be VBD cord-020235-stcrozdw 247 11 sequenced sequence VBN cord-020235-stcrozdw 247 12 to to TO cord-020235-stcrozdw 247 13 investigate investigate VB cord-020235-stcrozdw 247 14 two two CD cord-020235-stcrozdw 247 15 problems problem NNS cord-020235-stcrozdw 247 16 : : : cord-020235-stcrozdw 247 17 1 1 CD cord-020235-stcrozdw 247 18 . . . cord-020235-stcrozdw 248 1 Are be VBP cord-020235-stcrozdw 248 2 the the DT cord-020235-stcrozdw 248 3 sites site NNS cord-020235-stcrozdw 248 4 of of IN cord-020235-stcrozdw 248 5 insertion insertion NN cord-020235-stcrozdw 248 6 of of IN cord-020235-stcrozdw 248 7 viral viral JJ cord-020235-stcrozdw 248 8 DNA dna NN cord-020235-stcrozdw 248 9 specific specific JJ cord-020235-stcrozdw 248 10 ? ? . cord-020235-stcrozdw 248 11 2 2 CD cord-020235-stcrozdw 248 12 . . . cord-020235-stcrozdw 249 1 What what WDT cord-020235-stcrozdw 249 2 type type NN cord-020235-stcrozdw 249 3 of of IN cord-020235-stcrozdw 249 4 recombinatorial recombinatorial JJ cord-020235-stcrozdw 249 5 events event NNS cord-020235-stcrozdw 249 6 occur occur VBP cord-020235-stcrozdw 249 7 in in IN cord-020235-stcrozdw 249 8 viral viral JJ cord-020235-stcrozdw 249 9 DNA dna NN cord-020235-stcrozdw 249 10 integration integration NN cord-020235-stcrozdw 249 11 ? ? . cord-020235-stcrozdw 250 1 We -PRON- PRP cord-020235-stcrozdw 250 2 have have VBP cord-020235-stcrozdw 250 3 studied study VBN cord-020235-stcrozdw 250 4 junction junction NN cord-020235-stcrozdw 250 5 sites site NNS cord-020235-stcrozdw 250 6 from from IN cord-020235-stcrozdw 250 7 the the DT cord-020235-stcrozdw 250 8 Ad2-transformed Ad2-transformed NNP cord-020235-stcrozdw 250 9 hamster hamster NN cord-020235-stcrozdw 250 10 line line NN cord-020235-stcrozdw 250 11 HES HES NNP cord-020235-stcrozdw 250 12 , , , cord-020235-stcrozdw 250 13 and and CC cord-020235-stcrozdw 250 14 from from IN cord-020235-stcrozdw 250 15 the the DT cord-020235-stcrozdw 250 16 Ad12-induced Ad12-induced NNP cord-020235-stcrozdw 250 17 hamster hamster NN cord-020235-stcrozdw 250 18 tumor tumor NN cord-020235-stcrozdw 250 19 lines line NNS cord-020235-stcrozdw 250 20 CLACI CLACI NNP cord-020235-stcrozdw 250 21 and and CC cord-020235-stcrozdw 250 22 CLAC3 CLAC3 NNP cord-020235-stcrozdw 250 23 . . . cord-020235-stcrozdw 251 1 The the DT cord-020235-stcrozdw 251 2 virus virus NN cord-020235-stcrozdw 251 3 - - HYPH cord-020235-stcrozdw 251 4 cell cell NN cord-020235-stcrozdw 251 5 DNA dna NN cord-020235-stcrozdw 251 6 junctions junction NNS cord-020235-stcrozdw 251 7 were be VBD cord-020235-stcrozdw 251 8 cloned clone VBN cord-020235-stcrozdw 251 9 in in IN cord-020235-stcrozdw 251 10 the the DT cord-020235-stcrozdw 251 11 DNA dna NN cord-020235-stcrozdw 251 12 of of IN cord-020235-stcrozdw 251 13 bacteriophage bacteriophage NN cord-020235-stcrozdw 251 14 2gt 2gt CD cord-020235-stcrozdw 251 15 · · NFP cord-020235-stcrozdw 252 1 J.B. J.B. NNP cord-020235-stcrozdw 252 2 Appropriate appropriate JJ cord-020235-stcrozdw 252 3 restriction restriction NN cord-020235-stcrozdw 252 4 fragments fragment NNS cord-020235-stcrozdw 252 5 were be VBD cord-020235-stcrozdw 252 6 sequenced sequence VBN cord-020235-stcrozdw 252 7 by by IN cord-020235-stcrozdw 252 8 the the DT cord-020235-stcrozdw 252 9 Maxam Maxam NNP cord-020235-stcrozdw 252 10 - - HYPH cord-020235-stcrozdw 252 11 Gilbert Gilbert NNP cord-020235-stcrozdw 252 12 technique technique NN cord-020235-stcrozdw 252 13 . . . cord-020235-stcrozdw 253 1 There there EX cord-020235-stcrozdw 253 2 was be VBD cord-020235-stcrozdw 253 3 no no DT cord-020235-stcrozdw 253 4 direct direct JJ cord-020235-stcrozdw 253 5 sequence sequence NN cord-020235-stcrozdw 253 6 identity identity NN cord-020235-stcrozdw 253 7 apparent apparent JJ cord-020235-stcrozdw 253 8 at at IN cord-020235-stcrozdw 253 9 the the DT cord-020235-stcrozdw 253 10 viral viral JJ cord-020235-stcrozdw 253 11 and and CC cord-020235-stcrozdw 253 12 cellular cellular JJ cord-020235-stcrozdw 253 13 junction junction NN cord-020235-stcrozdw 253 14 sequences sequence NNS cord-020235-stcrozdw 253 15 . . . cord-020235-stcrozdw 254 1 Deletions deletion NNS cord-020235-stcrozdw 254 2 at at IN cord-020235-stcrozdw 254 3 the the DT cord-020235-stcrozdw 254 4 termini terminus NNS cord-020235-stcrozdw 254 5 of of IN cord-020235-stcrozdw 254 6 the the DT cord-020235-stcrozdw 254 7 viral viral JJ cord-020235-stcrozdw 254 8 genome genome NN cord-020235-stcrozdw 254 9 were be VBD cord-020235-stcrozdw 254 10 seen see VBN cord-020235-stcrozdw 254 11 involving involve VBG cord-020235-stcrozdw 254 12 5 5 CD cord-020235-stcrozdw 254 13 ( ( -LRB- cord-020235-stcrozdw 254 14 HE5 HE5 NNP cord-020235-stcrozdw 254 15 ) ) -RRB- cord-020235-stcrozdw 254 16 , , , cord-020235-stcrozdw 254 17 45 45 CD cord-020235-stcrozdw 254 18 ( ( -LRB- cord-020235-stcrozdw 254 19 CLAC3 CLAC3 NNP cord-020235-stcrozdw 254 20 ) ) -RRB- cord-020235-stcrozdw 254 21 or or CC cord-020235-stcrozdw 254 22 174 174 CD cord-020235-stcrozdw 254 23 ( ( -LRB- cord-020235-stcrozdw 254 24 CLACl CLACl NNS cord-020235-stcrozdw 254 25 ) ) -RRB- cord-020235-stcrozdw 254 26 nucleotides nucleotide NNS cord-020235-stcrozdw 254 27 . . . cord-020235-stcrozdw 255 1 Peculiar peculiar JJ cord-020235-stcrozdw 255 2 patch patch NN cord-020235-stcrozdw 255 3 type type NN cord-020235-stcrozdw 255 4 homologies homology NNS cord-020235-stcrozdw 255 5 between between IN cord-020235-stcrozdw 255 6 the the DT cord-020235-stcrozdw 255 7 cellular cellular JJ cord-020235-stcrozdw 255 8 and and CC cord-020235-stcrozdw 255 9 viral viral JJ cord-020235-stcrozdw 255 10 sequence sequence NN cord-020235-stcrozdw 255 11 adjacent adjacent JJ cord-020235-stcrozdw 255 12 to to IN cord-020235-stcrozdw 255 13 the the DT cord-020235-stcrozdw 255 14 site site NN cord-020235-stcrozdw 255 15 of of IN cord-020235-stcrozdw 255 16 junction junction NN cord-020235-stcrozdw 255 17 and and CC cord-020235-stcrozdw 255 18 also also RB cord-020235-stcrozdw 255 19 in in IN cord-020235-stcrozdw 255 20 remote remote JJ cord-020235-stcrozdw 255 21 areas area NNS cord-020235-stcrozdw 255 22 were be VBD cord-020235-stcrozdw 255 23 observed observe VBN cord-020235-stcrozdw 255 24 . . . cord-020235-stcrozdw 256 1 These these DT cord-020235-stcrozdw 256 2 patches patch NNS cord-020235-stcrozdw 256 3 may may MD cord-020235-stcrozdw 256 4 have have VB cord-020235-stcrozdw 256 5 an an DT cord-020235-stcrozdw 256 6 important important JJ cord-020235-stcrozdw 256 7 function function NN cord-020235-stcrozdw 256 8 in in IN cord-020235-stcrozdw 256 9 integrational integrational NNP cord-020235-stcrozdw 256 10 recombination recombination NN cord-020235-stcrozdw 256 11 . . . cord-020235-stcrozdw 257 1 BUTTNER BUTTNER NNP cord-020235-stcrozdw 257 2 , , , cord-020235-stcrozdw 257 3 W. W. NNP cord-020235-stcrozdw 257 4 , , , cord-020235-stcrozdw 257 5 VERES VERES NNP cord-020235-stcrozdw 257 6 - - HYPH cord-020235-stcrozdw 257 7 MaLNAR MaLNAR NNP cord-020235-stcrozdw 257 8 , , , cord-020235-stcrozdw 257 9 S. S. NNP cord-020235-stcrozdw 257 10 , , , cord-020235-stcrozdw 257 11 and and CC cord-020235-stcrozdw 257 12 BLOCK BLOCK NNP cord-020235-stcrozdw 257 13 , , , cord-020235-stcrozdw 257 14 J. J. NNP cord-020235-stcrozdw 258 1 As as IN cord-020235-stcrozdw 258 2 a a DT cord-020235-stcrozdw 258 3 first first JJ cord-020235-stcrozdw 258 4 step step NN cord-020235-stcrozdw 258 5 to to TO cord-020235-stcrozdw 258 6 understand understand VB cord-020235-stcrozdw 258 7 the the DT cord-020235-stcrozdw 258 8 relationship relationship NN cord-020235-stcrozdw 258 9 between between IN cord-020235-stcrozdw 258 10 structure structure NN cord-020235-stcrozdw 258 11 and and CC cord-020235-stcrozdw 258 12 function function NN cord-020235-stcrozdw 258 13 of of IN cord-020235-stcrozdw 258 14 the the DT cord-020235-stcrozdw 258 15 adenovirus adenovirus NN cord-020235-stcrozdw 258 16 type type NN cord-020235-stcrozdw 258 17 2 2 CD cord-020235-stcrozdw 258 18 DNA dna NN cord-020235-stcrozdw 258 19 binding binding NN cord-020235-stcrozdw 258 20 protein protein NN cord-020235-stcrozdw 258 21 ( ( -LRB- cord-020235-stcrozdw 258 22 Ad2 ad2 CD cord-020235-stcrozdw 258 23 DBP DBP NNP cord-020235-stcrozdw 258 24 ) ) -RRB- cord-020235-stcrozdw 258 25 we -PRON- PRP cord-020235-stcrozdw 258 26 have have VBP cord-020235-stcrozdw 258 27 begun begin VBN cord-020235-stcrozdw 258 28 to to TO cord-020235-stcrozdw 258 29 determine determine VB cord-020235-stcrozdw 258 30 the the DT cord-020235-stcrozdw 258 31 primary primary JJ cord-020235-stcrozdw 258 32 structure structure NN cord-020235-stcrozdw 258 33 of of IN cord-020235-stcrozdw 258 34 the the DT cord-020235-stcrozdw 258 35 DBP dbp NN cord-020235-stcrozdw 258 36 gene gene NN cord-020235-stcrozdw 258 37 . . . cord-020235-stcrozdw 259 1 The the DT cord-020235-stcrozdw 259 2 isolation isolation NN cord-020235-stcrozdw 259 3 and and CC cord-020235-stcrozdw 259 4 characterization characterization NN cord-020235-stcrozdw 259 5 of of IN cord-020235-stcrozdw 259 6 Tupaia Tupaia NNP cord-020235-stcrozdw 259 7 adenovirus adenovirus NN cord-020235-stcrozdw 259 8 ( ( -LRB- cord-020235-stcrozdw 259 9 TAV TAV NNP cord-020235-stcrozdw 259 10 ) ) -RRB- cord-020235-stcrozdw 259 11 has have VBZ cord-020235-stcrozdw 259 12 been be VBN cord-020235-stcrozdw 259 13 reported report VBN cord-020235-stcrozdw 259 14 . . . cord-020235-stcrozdw 260 1 In in IN cord-020235-stcrozdw 260 2 order order NN cord-020235-stcrozdw 260 3 to to TO cord-020235-stcrozdw 260 4 construct construct VB cord-020235-stcrozdw 260 5 a a DT cord-020235-stcrozdw 260 6 genetic genetic JJ cord-020235-stcrozdw 260 7 map map NN cord-020235-stcrozdw 260 8 of of IN cord-020235-stcrozdw 260 9 the the DT cord-020235-stcrozdw 260 10 TAV TAV NNP cord-020235-stcrozdw 260 11 genome genome VBP cord-020235-stcrozdw 260 12 the the DT cord-020235-stcrozdw 260 13 use use NN cord-020235-stcrozdw 260 14 of of IN cord-020235-stcrozdw 260 15 temperature temperature NN cord-020235-stcrozdw 260 16 - - HYPH cord-020235-stcrozdw 260 17 sensitive sensitive JJ cord-020235-stcrozdw 260 18 mutants mutant NNS cord-020235-stcrozdw 260 19 ( ( -LRB- cord-020235-stcrozdw 260 20 ts ts NNP cord-020235-stcrozdw 260 21 ) ) -RRB- cord-020235-stcrozdw 260 22 of of IN cord-020235-stcrozdw 260 23 TAV TAV NNP cord-020235-stcrozdw 260 24 was be VBD cord-020235-stcrozdw 260 25 necessary necessary JJ cord-020235-stcrozdw 260 26 . . . cord-020235-stcrozdw 261 1 -A -A : cord-020235-stcrozdw 261 2 variety variety NN cord-020235-stcrozdw 261 3 of of IN cord-020235-stcrozdw 261 4 ts ts JJ cord-020235-stcrozdw 261 5 mutants mutant NNS cord-020235-stcrozdw 261 6 of of IN cord-020235-stcrozdw 261 7 T T NNP cord-020235-stcrozdw 261 8 AV av NN cord-020235-stcrozdw 261 9 , , , cord-020235-stcrozdw 261 10 which which WDT cord-020235-stcrozdw 261 11 were be VBD cord-020235-stcrozdw 261 12 generated generate VBN cord-020235-stcrozdw 261 13 by by IN cord-020235-stcrozdw 261 14 treatment treatment NN cord-020235-stcrozdw 261 15 of of IN cord-020235-stcrozdw 261 16 T T NNP cord-020235-stcrozdw 261 17 AV av NN cord-020235-stcrozdw 261 18 virions virion NNS cord-020235-stcrozdw 261 19 ( ( -LRB- cord-020235-stcrozdw 261 20 1 1 CD cord-020235-stcrozdw 261 21 X x CD cord-020235-stcrozdw 261 22 10 10 CD cord-020235-stcrozdw 261 23 10 10 CD cord-020235-stcrozdw 261 24 pfu pfu NN cord-020235-stcrozdw 261 25 ) ) -RRB- cord-020235-stcrozdw 261 26 with with IN cord-020235-stcrozdw 261 27 hydroxylamine hydroxylamine CD cord-020235-stcrozdw 261 28 , , , cord-020235-stcrozdw 261 29 were be VBD cord-020235-stcrozdw 261 30 isolated isolate VBN cord-020235-stcrozdw 261 31 and and CC cord-020235-stcrozdw 261 32 preliminary preliminary JJ cord-020235-stcrozdw 261 33 characterized characterize VBN cord-020235-stcrozdw 261 34 . . . cord-020235-stcrozdw 262 1 Six six CD cord-020235-stcrozdw 262 2 of of IN cord-020235-stcrozdw 262 3 these these DT cord-020235-stcrozdw 262 4 mutants mutant NNS cord-020235-stcrozdw 262 5 its -PRON- PRP$ cord-020235-stcrozdw 262 6 : : : cord-020235-stcrozdw 262 7 1 1 CD cord-020235-stcrozdw 262 8 , , , cord-020235-stcrozdw 262 9 4 4 CD cord-020235-stcrozdw 262 10 , , , cord-020235-stcrozdw 262 11 11 11 CD cord-020235-stcrozdw 262 12 , , , cord-020235-stcrozdw 262 13 12 12 CD cord-020235-stcrozdw 262 14 , , , cord-020235-stcrozdw 262 15 13 13 CD cord-020235-stcrozdw 262 16 , , , cord-020235-stcrozdw 262 17 and and CC cord-020235-stcrozdw 262 18 54 54 CD cord-020235-stcrozdw 262 19 ) ) -RRB- cord-020235-stcrozdw 262 20 did do VBD cord-020235-stcrozdw 262 21 not not RB cord-020235-stcrozdw 262 22 replicate replicate VB cord-020235-stcrozdw 262 23 in in IN cord-020235-stcrozdw 262 24 Tupaia tupaia JJ cord-020235-stcrozdw 262 25 embryonic embryonic JJ cord-020235-stcrozdw 262 26 kidney kidney NN cord-020235-stcrozdw 262 27 cells cell NNS cord-020235-stcrozdw 262 28 at at IN cord-020235-stcrozdw 262 29 39.5 39.5 CD cord-020235-stcrozdw 262 30 DC DC NNP cord-020235-stcrozdw 262 31 , , , cord-020235-stcrozdw 262 32 but but CC cord-020235-stcrozdw 262 33 did do VBD cord-020235-stcrozdw 262 34 replicate replicate VB cord-020235-stcrozdw 262 35 well well RB cord-020235-stcrozdw 262 36 at at IN cord-020235-stcrozdw 262 37 32 32 CD cord-020235-stcrozdw 262 38 ° ° NN cord-020235-stcrozdw 262 39 C c NN cord-020235-stcrozdw 262 40 . . . cord-020235-stcrozdw 263 1 The the DT cord-020235-stcrozdw 263 2 characterization characterization NN cord-020235-stcrozdw 263 3 of of IN cord-020235-stcrozdw 263 4 these these DT cord-020235-stcrozdw 263 5 mutants mutant NNS cord-020235-stcrozdw 263 6 was be VBD cord-020235-stcrozdw 263 7 carried carry VBN cord-020235-stcrozdw 263 8 out out RP cord-020235-stcrozdw 263 9 using use VBG cord-020235-stcrozdw 263 10 complementation complementation NN cord-020235-stcrozdw 263 11 tests test NNS cord-020235-stcrozdw 263 12 , , , cord-020235-stcrozdw 263 13 host host NN cord-020235-stcrozdw 263 14 range range NN cord-020235-stcrozdw 263 15 studies study NNS cord-020235-stcrozdw 263 16 and and CC cord-020235-stcrozdw 263 17 DNA DNA NNP cord-020235-stcrozdw 263 18 anal anal JJ cord-020235-stcrozdw 263 19 ysis ysis NN cord-020235-stcrozdw 263 20 using use VBG cord-020235-stcrozdw 263 21 different different JJ cord-020235-stcrozdw 263 22 restriction restriction NN cord-020235-stcrozdw 263 23 enzymes enzyme NNS cord-020235-stcrozdw 263 24 . . . cord-020235-stcrozdw 264 1 According accord VBG cord-020235-stcrozdw 264 2 to to IN cord-020235-stcrozdw 264 3 complementation complementation NN cord-020235-stcrozdw 264 4 analysis analysis NN cord-020235-stcrozdw 264 5 four four CD cord-020235-stcrozdw 264 6 groups group NNS cord-020235-stcrozdw 264 7 were be VBD cord-020235-stcrozdw 264 8 determined determine VBN cord-020235-stcrozdw 264 9 : : : cord-020235-stcrozdw 264 10 group group NN cord-020235-stcrozdw 264 11 I I NNP cord-020235-stcrozdw 264 12 = = SYM cord-020235-stcrozdw 264 13 ts ts NNP cord-020235-stcrozdw 264 14 1 1 CD cord-020235-stcrozdw 264 15 , , , cord-020235-stcrozdw 264 16 group group NN cord-020235-stcrozdw 264 17 II II NNP cord-020235-stcrozdw 264 18 = = SYM cord-020235-stcrozdw 264 19 ts ts NNP cord-020235-stcrozdw 264 20 12 12 CD cord-020235-stcrozdw 264 21 , , , cord-020235-stcrozdw 264 22 group group NN cord-020235-stcrozdw 264 23 III III NNP cord-020235-stcrozdw 264 24 = = SYM cord-020235-stcrozdw 264 25 ts ts NNP cord-020235-stcrozdw 264 26 13 13 CD cord-020235-stcrozdw 264 27 , , , cord-020235-stcrozdw 264 28 and and CC cord-020235-stcrozdw 264 29 group group NN cord-020235-stcrozdw 264 30 IV IV NNP cord-020235-stcrozdw 264 31 = = SYM cord-020235-stcrozdw 264 32 ts ts NNP cord-020235-stcrozdw 264 33 4 4 CD cord-020235-stcrozdw 264 34 , , , cord-020235-stcrozdw 264 35 11 11 CD cord-020235-stcrozdw 264 36 , , , cord-020235-stcrozdw 264 37 and and CC cord-020235-stcrozdw 264 38 54 54 CD cord-020235-stcrozdw 264 39 . . . cord-020235-stcrozdw 265 1 The the DT cord-020235-stcrozdw 265 2 host host NN cord-020235-stcrozdw 265 3 rage rage NN cord-020235-stcrozdw 265 4 study study NN cord-020235-stcrozdw 265 5 revealed reveal VBD cord-020235-stcrozdw 265 6 that that IN cord-020235-stcrozdw 265 7 ts ts NNP cord-020235-stcrozdw 265 8 1 1 CD cord-020235-stcrozdw 265 9 and and CC cord-020235-stcrozdw 265 10 54 54 CD cord-020235-stcrozdw 265 11 also also RB cord-020235-stcrozdw 265 12 had have VBD cord-020235-stcrozdw 265 13 properties property NNS cord-020235-stcrozdw 265 14 of of IN cord-020235-stcrozdw 265 15 host host NN cord-020235-stcrozdw 265 16 range range NN cord-020235-stcrozdw 265 17 mutants mutant NNS cord-020235-stcrozdw 265 18 . . . cord-020235-stcrozdw 266 1 These these DT cord-020235-stcrozdw 266 2 mutants mutant NNS cord-020235-stcrozdw 266 3 did do VBD cord-020235-stcrozdw 266 4 not not RB cord-020235-stcrozdw 266 5 replicate replicate VB cord-020235-stcrozdw 266 6 in in IN cord-020235-stcrozdw 266 7 Tupaia Tupaia NNP cord-020235-stcrozdw 266 8 bab bab NNP cord-020235-stcrozdw 266 9 y y NNP cord-020235-stcrozdw 266 10 fibroblasts fibroblast NNS cord-020235-stcrozdw 266 11 in in IN cord-020235-stcrozdw 266 12 contrast contrast NN cord-020235-stcrozdw 266 13 to to IN cord-020235-stcrozdw 266 14 wild wild JJ cord-020235-stcrozdw 266 15 - - HYPH cord-020235-stcrozdw 266 16 type type NN cord-020235-stcrozdw 266 17 virus virus NN cord-020235-stcrozdw 266 18 . . . cord-020235-stcrozdw 267 1 Genome genome NN cord-020235-stcrozdw 267 2 analysis analysis NN cord-020235-stcrozdw 267 3 of of IN cord-020235-stcrozdw 267 4 these these DT cord-020235-stcrozdw 267 5 mutants mutant NNS cord-020235-stcrozdw 267 6 revealed reveal VBD cord-020235-stcrozdw 267 7 that that IN cord-020235-stcrozdw 267 8 the the DT cord-020235-stcrozdw 267 9 mutated mutated JJ cord-020235-stcrozdw 267 10 region region NN cord-020235-stcrozdw 267 11 is be VBZ cord-020235-stcrozdw 267 12 located locate VBN cord-020235-stcrozdw 267 13 between between IN cord-020235-stcrozdw 267 14 69.9 69.9 CD cord-020235-stcrozdw 267 15 to to IN cord-020235-stcrozdw 267 16 74.5 74.5 CD cord-020235-stcrozdw 267 17 map map NN cord-020235-stcrozdw 267 18 units unit NNS cord-020235-stcrozdw 267 19 . . . cord-020235-stcrozdw 268 1 In in IN cord-020235-stcrozdw 268 2 addition addition NN cord-020235-stcrozdw 268 3 , , , cord-020235-stcrozdw 268 4 in in IN cord-020235-stcrozdw 268 5 ts ts NNP cord-020235-stcrozdw 268 6 1 1 CD cord-020235-stcrozdw 268 7 and and CC cord-020235-stcrozdw 268 8 54 54 CD cord-020235-stcrozdw 268 9 mutants mutant NNS cord-020235-stcrozdw 268 10 a a DT cord-020235-stcrozdw 268 11 deletion deletion NN cord-020235-stcrozdw 268 12 from from IN cord-020235-stcrozdw 268 13 0.77 0.77 CD cord-020235-stcrozdw 268 14 Kb Kb NNP cord-020235-stcrozdw 268 15 to to IN cord-020235-stcrozdw 268 16 1.39 1.39 CD cord-020235-stcrozdw 268 17 Kb Kb NNP cord-020235-stcrozdw 268 18 ( ( -LRB- cord-020235-stcrozdw 268 19 map map NNP cord-020235-stcrozdw 268 20 unit unit NN cord-020235-stcrozdw 268 21 76.5 76.5 CD cord-020235-stcrozdw 268 22 to to IN cord-020235-stcrozdw 268 23 100 100 CD cord-020235-stcrozdw 268 24 ) ) -RRB- cord-020235-stcrozdw 268 25 was be VBD cord-020235-stcrozdw 268 26 detected detect VBN cord-020235-stcrozdw 268 27 . . . cord-020235-stcrozdw 269 1 Interaction interaction NN cord-020235-stcrozdw 269 2 of of IN cord-020235-stcrozdw 269 3 Viral Viral NNP cord-020235-stcrozdw 269 4 Substructures Substructures NNPS cord-020235-stcrozdw 269 5 with with IN cord-020235-stcrozdw 269 6 Serum Serum NNP cord-020235-stcrozdw 269 7 and and CC cord-020235-stcrozdw 269 8 Serumcomponents Serumcomponents NNP cord-020235-stcrozdw 269 9 resp resp NNP cord-020235-stcrozdw 269 10 . . . cord-020235-stcrozdw 270 1 During during IN cord-020235-stcrozdw 270 2 the the DT cord-020235-stcrozdw 270 3 final final JJ cord-020235-stcrozdw 270 4 stage stage NN cord-020235-stcrozdw 270 5 in in IN cord-020235-stcrozdw 270 6 the the DT cord-020235-stcrozdw 270 7 course course NN cord-020235-stcrozdw 270 8 of of IN cord-020235-stcrozdw 270 9 many many JJ cord-020235-stcrozdw 270 10 viral viral JJ cord-020235-stcrozdw 270 11 infections infection NNS cord-020235-stcrozdw 270 12 complete complete JJ cord-020235-stcrozdw 270 13 virus virus NN cord-020235-stcrozdw 270 14 particles particle NNS cord-020235-stcrozdw 270 15 as as RB cord-020235-stcrozdw 270 16 well well RB cord-020235-stcrozdw 270 17 as as IN cord-020235-stcrozdw 270 18 viral viral JJ cord-020235-stcrozdw 270 19 substructures substructure NNS cord-020235-stcrozdw 270 20 enter enter VBP cord-020235-stcrozdw 270 21 the the DT cord-020235-stcrozdw 270 22 intercellular intercellular JJ cord-020235-stcrozdw 270 23 space space NN cord-020235-stcrozdw 270 24 , , , cord-020235-stcrozdw 270 25 e. e. NNP cord-020235-stcrozdw 270 26 g. g. NNP cord-020235-stcrozdw 270 27 HBsAG HBsAG NNP cord-020235-stcrozdw 270 28 , , , cord-020235-stcrozdw 270 29 HBcAG HBcAG NNP cord-020235-stcrozdw 270 30 in in IN cord-020235-stcrozdw 270 31 hepatitis hepatitis NN cord-020235-stcrozdw 270 32 B B NNP cord-020235-stcrozdw 270 33 virus virus NN cord-020235-stcrozdw 270 34 infections infection NNS cord-020235-stcrozdw 270 35 . . . cord-020235-stcrozdw 271 1 The the DT cord-020235-stcrozdw 271 2 present present JJ cord-020235-stcrozdw 271 3 study study NN cord-020235-stcrozdw 271 4 deals deal NNS cord-020235-stcrozdw 271 5 on on IN cord-020235-stcrozdw 271 6 the the DT cord-020235-stcrozdw 271 7 interaction interaction NN cord-020235-stcrozdw 271 8 of of IN cord-020235-stcrozdw 271 9 the the DT cord-020235-stcrozdw 271 10 potentially potentially RB cord-020235-stcrozdw 271 11 infectious infectious JJ cord-020235-stcrozdw 271 12 adenovirus adenovirus NN cord-020235-stcrozdw 271 13 cores core NNS cord-020235-stcrozdw 271 14 with with IN cord-020235-stcrozdw 271 15 DNA dna NN cord-020235-stcrozdw 271 16 - - HYPH cord-020235-stcrozdw 271 17 specific specific JJ cord-020235-stcrozdw 271 18 antibodies antibody NNS cord-020235-stcrozdw 271 19 and and CC cord-020235-stcrozdw 271 20 immunoglobulin immunoglobulin NN cord-020235-stcrozdw 271 21 solutions solution NNS cord-020235-stcrozdw 271 22 which which WDT cord-020235-stcrozdw 271 23 had have VBD cord-020235-stcrozdw 271 24 been be VBN cord-020235-stcrozdw 271 25 absorbed absorb VBN cord-020235-stcrozdw 271 26 by by IN cord-020235-stcrozdw 271 27 DNA dna NN cord-020235-stcrozdw 271 28 - - HYPH cord-020235-stcrozdw 271 29 antigens antigen NNS cord-020235-stcrozdw 271 30 . . . cord-020235-stcrozdw 272 1 Cores core NNS cord-020235-stcrozdw 272 2 were be VBD cord-020235-stcrozdw 272 3 prepared prepare VBN cord-020235-stcrozdw 272 4 by by IN cord-020235-stcrozdw 272 5 sarcosyl sarcosyl JJ cord-020235-stcrozdw 272 6 treatment treatment NN cord-020235-stcrozdw 272 7 of of IN cord-020235-stcrozdw 272 8 purified purify VBN cord-020235-stcrozdw 272 9 adenovirus adenovirus NN cord-020235-stcrozdw 272 10 typ typ NNP cord-020235-stcrozdw 272 11 5 5 CD cord-020235-stcrozdw 272 12 . . . cord-020235-stcrozdw 273 1 By by IN cord-020235-stcrozdw 273 2 electron electron NN cord-020235-stcrozdw 273 3 microscopy microscopy NN cord-020235-stcrozdw 273 4 immunocomplexes immunocomplexe NNS cord-020235-stcrozdw 273 5 could could MD cord-020235-stcrozdw 273 6 be be VB cord-020235-stcrozdw 273 7 demonstrated demonstrate VBN cord-020235-stcrozdw 273 8 which which WDT cord-020235-stcrozdw 273 9 are be VBP cord-020235-stcrozdw 273 10 composed compose VBN cord-020235-stcrozdw 273 11 of of IN cord-020235-stcrozdw 273 12 several several JJ cord-020235-stcrozdw 273 13 individual individual JJ cord-020235-stcrozdw 273 14 core core NN cord-020235-stcrozdw 273 15 units unit NNS cord-020235-stcrozdw 273 16 . . . cord-020235-stcrozdw 274 1 By by IN cord-020235-stcrozdw 274 2 buoyant buoyant JJ cord-020235-stcrozdw 274 3 density density NN cord-020235-stcrozdw 274 4 centrifugation centrifugation NN cord-020235-stcrozdw 274 5 in in IN cord-020235-stcrozdw 274 6 metrizamide metrizamide NN cord-020235-stcrozdw 274 7 gradients gradient NNS cord-020235-stcrozdw 274 8 a a DT cord-020235-stcrozdw 274 9 drastic drastic JJ cord-020235-stcrozdw 274 10 rise rise NN cord-020235-stcrozdw 274 11 in in IN cord-020235-stcrozdw 274 12 the the DT cord-020235-stcrozdw 274 13 density density NN cord-020235-stcrozdw 274 14 of of IN cord-020235-stcrozdw 274 15 cores core NNS cord-020235-stcrozdw 274 16 could could MD cord-020235-stcrozdw 274 17 be be VB cord-020235-stcrozdw 274 18 shown show VBN cord-020235-stcrozdw 274 19 too too RB cord-020235-stcrozdw 274 20 . . . cord-020235-stcrozdw 275 1 With with IN cord-020235-stcrozdw 275 2 immunoglobulin immunoglobulin NN cord-020235-stcrozdw 275 3 solutions solution NNS cord-020235-stcrozdw 275 4 , , , cord-020235-stcrozdw 275 5 absorbed absorb VBN cord-020235-stcrozdw 275 6 with with IN cord-020235-stcrozdw 275 7 native native JJ cord-020235-stcrozdw 275 8 as as RB cord-020235-stcrozdw 275 9 well well RB cord-020235-stcrozdw 275 10 as as IN cord-020235-stcrozdw 275 11 with with IN cord-020235-stcrozdw 275 12 denatured denature VBN cord-020235-stcrozdw 275 13 DNA dna NN cord-020235-stcrozdw 275 14 , , , cord-020235-stcrozdw 275 15 so so RB cord-020235-stcrozdw 275 16 far far RB cord-020235-stcrozdw 275 17 no no DT cord-020235-stcrozdw 275 18 complexes complex NNS cord-020235-stcrozdw 275 19 could could MD cord-020235-stcrozdw 275 20 be be VB cord-020235-stcrozdw 275 21 assessed assess VBN cord-020235-stcrozdw 275 22 . . . cord-020235-stcrozdw 276 1 A a DT cord-020235-stcrozdw 276 2 cell cell NN cord-020235-stcrozdw 276 3 line line NN cord-020235-stcrozdw 276 4 designated designate VBN cord-020235-stcrozdw 276 5 SBL SBL NNP cord-020235-stcrozdw 276 6 - - HYPH cord-020235-stcrozdw 276 7 H12578 H12578 NNP cord-020235-stcrozdw 276 8 and and CC cord-020235-stcrozdw 276 9 several several JJ cord-020235-stcrozdw 276 10 cell cell NN cord-020235-stcrozdw 276 11 clones clone NNS cord-020235-stcrozdw 276 12 were be VBD cord-020235-stcrozdw 276 13 established establish VBN cord-020235-stcrozdw 276 14 from from IN cord-020235-stcrozdw 276 15 skin skin NN cord-020235-stcrozdw 276 16 tumours tumour NNS cord-020235-stcrozdw 276 17 of of IN cord-020235-stcrozdw 276 18 the the DT cord-020235-stcrozdw 276 19 sporadic sporadic JJ cord-020235-stcrozdw 276 20 leukosis leukosis NN cord-020235-stcrozdw 276 21 form form NN cord-020235-stcrozdw 276 22 . . . cord-020235-stcrozdw 277 1 The the DT cord-020235-stcrozdw 277 2 cells cell NNS cord-020235-stcrozdw 277 3 were be VBD cord-020235-stcrozdw 277 4 proved prove VBN cord-020235-stcrozdw 277 5 to to TO cord-020235-stcrozdw 277 6 be be VB cord-020235-stcrozdw 277 7 free free JJ cord-020235-stcrozdw 277 8 of of IN cord-020235-stcrozdw 277 9 bovine bovine JJ cord-020235-stcrozdw 277 10 leukemia leukemia NN cord-020235-stcrozdw 277 11 ( ( -LRB- cord-020235-stcrozdw 277 12 BLV BLV NNP cord-020235-stcrozdw 277 13 ) ) -RRB- cord-020235-stcrozdw 277 14 , , , cord-020235-stcrozdw 277 15 and and CC cord-020235-stcrozdw 277 16 some some DT cord-020235-stcrozdw 277 17 other other JJ cord-020235-stcrozdw 277 18 bovine bovine JJ cord-020235-stcrozdw 277 19 viruses virus NNS cord-020235-stcrozdw 277 20 . . . cord-020235-stcrozdw 278 1 By by IN cord-020235-stcrozdw 278 2 indirect indirect JJ cord-020235-stcrozdw 278 3 immunofluorescence immunofluorescence NN cord-020235-stcrozdw 278 4 macroschizonts macroschizont NNS cord-020235-stcrozdw 278 5 of of IN cord-020235-stcrozdw 278 6 a a DT cord-020235-stcrozdw 278 7 Theileria Theileria NNP cord-020235-stcrozdw 278 8 species specie NNS cord-020235-stcrozdw 278 9 were be VBD cord-020235-stcrozdw 278 10 seen see VBN cord-020235-stcrozdw 278 11 in in IN cord-020235-stcrozdw 278 12 the the DT cord-020235-stcrozdw 278 13 cytoplasm cytoplasm NN cord-020235-stcrozdw 278 14 . . . cord-020235-stcrozdw 279 1 The the DT cord-020235-stcrozdw 279 2 cells cell NNS cord-020235-stcrozdw 279 3 originated originate VBD cord-020235-stcrozdw 279 4 from from IN cord-020235-stcrozdw 279 5 a a DT cord-020235-stcrozdw 279 6 BLVantibody BLVantibody NNP cord-020235-stcrozdw 279 7 negative negative JJ cord-020235-stcrozdw 279 8 animal animal NN cord-020235-stcrozdw 279 9 and and CC cord-020235-stcrozdw 279 10 carried carry VBD cord-020235-stcrozdw 279 11 a a DT cord-020235-stcrozdw 279 12 female female JJ cord-020235-stcrozdw 279 13 karyotype karyotype NN cord-020235-stcrozdw 279 14 with with IN cord-020235-stcrozdw 279 15 some some DT cord-020235-stcrozdw 279 16 morphological morphological JJ cord-020235-stcrozdw 279 17 aberrations aberration NNS cord-020235-stcrozdw 279 18 . . . cord-020235-stcrozdw 280 1 Evidence evidence NN cord-020235-stcrozdw 280 2 for for IN cord-020235-stcrozdw 280 3 a a DT cord-020235-stcrozdw 280 4 possible possible JJ cord-020235-stcrozdw 280 5 T T NNP cord-020235-stcrozdw 280 6 cell cell NN cord-020235-stcrozdw 280 7 origin origin NN cord-020235-stcrozdw 280 8 of of IN cord-020235-stcrozdw 280 9 SBL SBL NNP cord-020235-stcrozdw 280 10 - - HYPH cord-020235-stcrozdw 280 11 H12578 H12578 NNP cord-020235-stcrozdw 280 12 cells cell NNS cord-020235-stcrozdw 280 13 was be VBD cord-020235-stcrozdw 280 14 obtained obtain VBN cord-020235-stcrozdw 280 15 . . . cord-020235-stcrozdw 281 1 After after IN cord-020235-stcrozdw 281 2 inoculation inoculation NN cord-020235-stcrozdw 281 3 of of IN cord-020235-stcrozdw 281 4 8 8 CD cord-020235-stcrozdw 281 5 X x NN cord-020235-stcrozdw 281 6 lOa lOa NNS cord-020235-stcrozdw 281 7 cells cell NNS cord-020235-stcrozdw 281 8 into into IN cord-020235-stcrozdw 281 9 ' ' `` cord-020235-stcrozdw 281 10 nude nude JJ cord-020235-stcrozdw 281 11 mice mouse NNS cord-020235-stcrozdw 281 12 ' ' POS cord-020235-stcrozdw 281 13 transplantable transplantable JJ cord-020235-stcrozdw 281 14 SBL SBL NNP cord-020235-stcrozdw 281 15 - - HYPH cord-020235-stcrozdw 281 16 H12578 H12578 NNP cord-020235-stcrozdw 281 17 tumours tumour NNS cord-020235-stcrozdw 281 18 developed develop VBD cord-020235-stcrozdw 281 19 . . . cord-020235-stcrozdw 282 1 By by IN cord-020235-stcrozdw 282 2 incorporarion incorporarion NN cord-020235-stcrozdw 282 3 of of IN cord-020235-stcrozdw 282 4 3H 3H NNP cord-020235-stcrozdw 282 5 - - HYPH cord-020235-stcrozdw 282 6 uridine uridine NN cord-020235-stcrozdw 282 7 and and CC cord-020235-stcrozdw 282 8 electron electron NN cord-020235-stcrozdw 282 9 microscopy microscopy NNS cord-020235-stcrozdw 282 10 , , , cord-020235-stcrozdw 282 11 the the DT cord-020235-stcrozdw 282 12 production production NN cord-020235-stcrozdw 282 13 of of IN cord-020235-stcrozdw 282 14 retrovirus retrovirus NN cord-020235-stcrozdw 282 15 particles particle NNS cord-020235-stcrozdw 282 16 by by IN cord-020235-stcrozdw 282 17 the the DT cord-020235-stcrozdw 282 18 cultured cultured JJ cord-020235-stcrozdw 282 19 cells cell NNS cord-020235-stcrozdw 282 20 was be VBD cord-020235-stcrozdw 282 21 detected detect VBN cord-020235-stcrozdw 282 22 . . . cord-020235-stcrozdw 283 1 In in IN cord-020235-stcrozdw 283 2 the the DT cord-020235-stcrozdw 283 3 simultaneous simultaneous JJ cord-020235-stcrozdw 283 4 detection detection NN cord-020235-stcrozdw 283 5 test test NN cord-020235-stcrozdw 283 6 a a DT cord-020235-stcrozdw 283 7 highmolecular highmolecular NNP cord-020235-stcrozdw 283 8 weight weight NN cord-020235-stcrozdw 283 9 RNA RNA NNP cord-020235-stcrozdw 283 10 co co NN cord-020235-stcrozdw 283 11 - - NN cord-020235-stcrozdw 283 12 migrating migrate VBG cord-020235-stcrozdw 283 13 with with IN cord-020235-stcrozdw 283 14 FeLV FeLV NNP cord-020235-stcrozdw 283 15 70 70 CD cord-020235-stcrozdw 284 1 S S NNP cord-020235-stcrozdw 284 2 RNA RNA NNP cord-020235-stcrozdw 284 3 was be VBD cord-020235-stcrozdw 284 4 demonstrated demonstrate VBN cord-020235-stcrozdw 284 5 . . . cord-020235-stcrozdw 285 1 No no DT cord-020235-stcrozdw 285 2 antigenic antigenic JJ cord-020235-stcrozdw 285 3 or or CC cord-020235-stcrozdw 285 4 genetic genetic JJ cord-020235-stcrozdw 285 5 relationship relationship NN cord-020235-stcrozdw 285 6 between between IN cord-020235-stcrozdw 285 7 th th XX cord-020235-stcrozdw 285 8 e e NN cord-020235-stcrozdw 285 9 skin skin NN cord-020235-stcrozdw 285 10 tumour tumour NN cord-020235-stcrozdw 285 11 virus virus NN cord-020235-stcrozdw 285 12 isolate isolate VBP cord-020235-stcrozdw 285 13 and and CC cord-020235-stcrozdw 285 14 BLV BLV NNP cord-020235-stcrozdw 285 15 or or CC cord-020235-stcrozdw 285 16 other other JJ cord-020235-stcrozdw 285 17 major major JJ cord-020235-stcrozdw 285 18 mammalian mammalian JJ cord-020235-stcrozdw 285 19 retrov retrov NN cord-020235-stcrozdw 285 20 iruses iruses NNP cord-020235-stcrozdw 285 21 has have VBZ cord-020235-stcrozdw 285 22 been be VBN cord-020235-stcrozdw 285 23 found find VBN cord-020235-stcrozdw 285 24 . . . cord-020235-stcrozdw 286 1 -(Supported -(supporte VBN cord-020235-stcrozdw 286 2 by by IN cord-020235-stcrozdw 286 3 Stiftung Stiftung NNP cord-020235-stcrozdw 286 4 Volkswagenwerk Volkswagenwerk NNP cord-020235-stcrozdw 286 5 ) ) -RRB- cord-020235-stcrozdw 286 6 . . . cord-020235-stcrozdw 287 1 Abt Abt NNP cord-020235-stcrozdw 287 2 . . . cord-020235-stcrozdw 288 1 f. f. NNP cord-020235-stcrozdw 288 2 Pathologie Pathologie NNP cord-020235-stcrozdw 288 3 , , , cord-020235-stcrozdw 288 4 Gesellschafl Gesellschafl NNP cord-020235-stcrozdw 288 5 : : : cord-020235-stcrozdw 288 6 f. f. NNP cord-020235-stcrozdw 288 7 Strahlen Strahlen NNP cord-020235-stcrozdw 288 8 - - HYPH cord-020235-stcrozdw 288 9 u u NNP cord-020235-stcrozdw 288 10 . . . cord-020235-stcrozdw 289 1 Umweldorschung Umweldorschung NNP cord-020235-stcrozdw 289 2 , , , cord-020235-stcrozdw 290 1 D-8042 D-8042 NNP cord-020235-stcrozdw 291 1 Neuherberg Neuherberg NNP cord-020235-stcrozdw 291 2 Insectpathogenic Insectpathogenic NNP cord-020235-stcrozdw 291 3 Baculoviruses Baculoviruses NNPS cord-020235-stcrozdw 291 4 : : : cord-020235-stcrozdw 291 5 Studies study NNS cord-020235-stcrozdw 291 6 of of IN cord-020235-stcrozdw 291 7 the the DT cord-020235-stcrozdw 291 8 Activation Activation NNP cord-020235-stcrozdw 291 9 of of IN cord-020235-stcrozdw 291 10 Endogenous Endogenous NNP cord-020235-stcrozdw 291 11 C c NN cord-020235-stcrozdw 291 12 - - HYPH cord-020235-stcrozdw 291 13 type type NN cord-020235-stcrozdw 291 14 Retroviruses retrovirus NNS cord-020235-stcrozdw 291 15 in in IN cord-020235-stcrozdw 291 16 Mammalian mammalian JJ cord-020235-stcrozdw 291 17 Cell Cell NNP cord-020235-stcrozdw 291 18 Cultures Cultures NNPS cord-020235-stcrozdw 291 19 SCHMIDT SCHMIDT NNP cord-020235-stcrozdw 291 20 , , , cord-020235-stcrozdw 291 21 J. J. NNP cord-020235-stcrozdw 291 22 and and CC cord-020235-stcrozdw 291 23 ERFLE ERFLE NNP cord-020235-stcrozdw 291 24 , , , cord-020235-stcrozdw 291 25 V. V. NNP cord-020235-stcrozdw 291 26 Activation Activation NNP cord-020235-stcrozdw 291 27 of of IN cord-020235-stcrozdw 291 28 endogenous endogenous JJ cord-020235-stcrozdw 291 29 C c NN cord-020235-stcrozdw 291 30 - - HYPH cord-020235-stcrozdw 291 31 type type NN cord-020235-stcrozdw 291 32 retroviruses retrovirus NNS cord-020235-stcrozdw 291 33 by by IN cord-020235-stcrozdw 291 34 Baculoviruses Baculoviruses NNPS cord-020235-stcrozdw 291 35 was be VBD cord-020235-stcrozdw 291 36 studied study VBN cord-020235-stcrozdw 291 37 in in IN cord-020235-stcrozdw 291 38 " " `` cord-020235-stcrozdw 291 39 in in FW cord-020235-stcrozdw 291 40 vitro vitro FW cord-020235-stcrozdw 291 41 " " '' cord-020235-stcrozdw 291 42 cell cell NN cord-020235-stcrozdw 291 43 culture culture NN cord-020235-stcrozdw 291 44 systems system NNS cord-020235-stcrozdw 291 45 of of IN cord-020235-stcrozdw 291 46 four four CD cord-020235-stcrozdw 291 47 mammalian mammalian JJ cord-020235-stcrozdw 291 48 species specie NNS cord-020235-stcrozdw 291 49 : : : cord-020235-stcrozdw 291 50 mouse mouse NN cord-020235-stcrozdw 291 51 , , , cord-020235-stcrozdw 291 52 rat rat NN cord-020235-stcrozdw 291 53 , , , cord-020235-stcrozdw 291 54 monkey monkey NN cord-020235-stcrozdw 291 55 and and CC cord-020235-stcrozdw 291 56 man man NN cord-020235-stcrozdw 291 57 . . . cord-020235-stcrozdw 292 1 Cells cell NNS cord-020235-stcrozdw 292 2 were be VBD cord-020235-stcrozdw 292 3 treated treat VBN cord-020235-stcrozdw 292 4 with with IN cord-020235-stcrozdw 292 5 Baculoviruses Baculoviruses NNP cord-020235-stcrozdw 292 6 ( ( -LRB- cord-020235-stcrozdw 292 7 from from IN cord-020235-stcrozdw 292 8 larvae larva NNS cord-020235-stcrozdw 292 9 and and CC cord-020235-stcrozdw 292 10 insect insect NN cord-020235-stcrozdw 292 11 cell cell NN cord-020235-stcrozdw 292 12 cultures culture NNS cord-020235-stcrozdw 292 13 ) ) -RRB- cord-020235-stcrozdw 292 14 , , , cord-020235-stcrozdw 292 15 Baculovirus Baculovirus NNP cord-020235-stcrozdw 292 16 - - HYPH cord-020235-stcrozdw 292 17 DNA DNA NNP cord-020235-stcrozdw 292 18 , , , cord-020235-stcrozdw 292 19 C c NN cord-020235-stcrozdw 292 20 - - HYPH cord-020235-stcrozdw 292 21 rype rype NN cord-020235-stcrozdw 292 22 retrovirus retrovirus NN cord-020235-stcrozdw 292 23 - - HYPH cord-020235-stcrozdw 292 24 activating activate VBG cord-020235-stcrozdw 292 25 chemicals chemical NNS cord-020235-stcrozdw 292 26 and and CC cord-020235-stcrozdw 292 27 chemical chemical NN cord-020235-stcrozdw 292 28 insecticides insecticide NNS cord-020235-stcrozdw 292 29 alone alone RB cord-020235-stcrozdw 292 30 and and CC cord-020235-stcrozdw 292 31 in in IN cord-020235-stcrozdw 292 32 combination combination NN cord-020235-stcrozdw 292 33 . . . cord-020235-stcrozdw 293 1 The the DT cord-020235-stcrozdw 293 2 activation activation NN cord-020235-stcrozdw 293 3 of of IN cord-020235-stcrozdw 293 4 retroviral retroviral JJ cord-020235-stcrozdw 293 5 genomes genome NNS cord-020235-stcrozdw 293 6 was be VBD cord-020235-stcrozdw 293 7 tested test VBN cord-020235-stcrozdw 293 8 by by IN cord-020235-stcrozdw 293 9 the the DT cord-020235-stcrozdw 293 10 determination determination NN cord-020235-stcrozdw 293 11 of of IN cord-020235-stcrozdw 293 12 reverse reverse JJ cord-020235-stcrozdw 293 13 transcriptase transcriptase NN cord-020235-stcrozdw 293 14 activiry activiry NN cord-020235-stcrozdw 293 15 in in IN cord-020235-stcrozdw 293 16 concentrated concentrated JJ cord-020235-stcrozdw 293 17 cell cell NN cord-020235-stcrozdw 293 18 culture culture NN cord-020235-stcrozdw 293 19 supernatants supernatant NNS cord-020235-stcrozdw 293 20 and and CC cord-020235-stcrozdw 293 21 by by IN cord-020235-stcrozdw 293 22 the the DT cord-020235-stcrozdw 293 23 demonstration demonstration NN cord-020235-stcrozdw 293 24 of of IN cord-020235-stcrozdw 293 25 the the DT cord-020235-stcrozdw 293 26 intracellular intracellular JJ cord-020235-stcrozdw 293 27 localisation localisation NN cord-020235-stcrozdw 293 28 of of IN cord-020235-stcrozdw 293 29 retrovirus retrovirus NN cord-020235-stcrozdw 293 30 structural structural JJ cord-020235-stcrozdw 293 31 protein protein NN cord-020235-stcrozdw 293 32 p30 p30 NNP cord-020235-stcrozdw 293 33 applying apply VBG cord-020235-stcrozdw 293 34 the the DT cord-020235-stcrozdw 293 35 indirect indirect JJ cord-020235-stcrozdw 293 36 immunoperoxydase immunoperoxydase NN cord-020235-stcrozdw 293 37 technique technique NN cord-020235-stcrozdw 293 38 . . . cord-020235-stcrozdw 294 1 -C -C : cord-020235-stcrozdw 294 2 - - HYPH cord-020235-stcrozdw 294 3 type type NN cord-020235-stcrozdw 294 4 retroviruses retrovirus NNS cord-020235-stcrozdw 294 5 were be VBD cord-020235-stcrozdw 294 6 activated activate VBN cord-020235-stcrozdw 294 7 in in IN cord-020235-stcrozdw 294 8 mouse mouse NN cord-020235-stcrozdw 294 9 cells cell NNS cord-020235-stcrozdw 294 10 only only RB cord-020235-stcrozdw 294 11 by by IN cord-020235-stcrozdw 294 12 the the DT cord-020235-stcrozdw 294 13 halogenated halogenate VBN cord-020235-stcrozdw 294 14 pyrimidine pyrimidine NN cord-020235-stcrozdw 294 15 analogue analogue NNP cord-020235-stcrozdw 294 16 iododeoxyuridine iododeoxyuridine NNP cord-020235-stcrozdw 294 17 . . . cord-020235-stcrozdw 295 1 In in IN cord-020235-stcrozdw 295 2 Baculovirus Baculovirus NNP cord-020235-stcrozdw 295 3 - - HYPH cord-020235-stcrozdw 295 4 treated treat VBN cord-020235-stcrozdw 295 5 cell cell NN cord-020235-stcrozdw 295 6 cultures culture NNS cord-020235-stcrozdw 295 7 no no DT cord-020235-stcrozdw 295 8 C c NN cord-020235-stcrozdw 295 9 - - HYPH cord-020235-stcrozdw 295 10 type type NN cord-020235-stcrozdw 295 11 retrovirus retrovirus NN cord-020235-stcrozdw 295 12 activation activation NN cord-020235-stcrozdw 295 13 was be VBD cord-020235-stcrozdw 295 14 detectable detectable JJ cord-020235-stcrozdw 295 15 . . . cord-020235-stcrozdw 296 1 In in IN cord-020235-stcrozdw 296 2 simultaneous simultaneous JJ cord-020235-stcrozdw 296 3 treatments treatment NNS cord-020235-stcrozdw 296 4 of of IN cord-020235-stcrozdw 296 5 the the DT cord-020235-stcrozdw 296 6 cells cell NNS cord-020235-stcrozdw 296 7 with with IN cord-020235-stcrozdw 296 8 Baculoviruses Baculoviruses NNPS cord-020235-stcrozdw 296 9 and and CC cord-020235-stcrozdw 296 10 chemicals chemical NNS cord-020235-stcrozdw 296 11 no no DT cord-020235-stcrozdw 296 12 potentiating potentiate VBG cord-020235-stcrozdw 296 13 effects effect NNS cord-020235-stcrozdw 296 14 could could MD cord-020235-stcrozdw 296 15 be be VB cord-020235-stcrozdw 296 16 detected detect VBN cord-020235-stcrozdw 296 17 . . . cord-020235-stcrozdw 297 1 Virions Virions NNP cord-020235-stcrozdw 297 2 of of IN cord-020235-stcrozdw 297 3 Baculoviruses Baculoviruses NNP cord-020235-stcrozdw 297 4 in in IN cord-020235-stcrozdw 297 5 mammalian mammalian JJ cord-020235-stcrozdw 297 6 cell cell NN cord-020235-stcrozdw 297 7 cultures culture NNS cord-020235-stcrozdw 297 8 showed show VBD cord-020235-stcrozdw 297 9 unaltered unaltered JJ cord-020235-stcrozdw 297 10 morphology morphology NN cord-020235-stcrozdw 297 11 and and CC cord-020235-stcrozdw 297 12 upon upon IN cord-020235-stcrozdw 297 13 reisolation reisolation NN cord-020235-stcrozdw 297 14 their -PRON- PRP$ cord-020235-stcrozdw 297 15 infectivity infectivity NN cord-020235-stcrozdw 297 16 in in IN cord-020235-stcrozdw 297 17 homologous homologous JJ cord-020235-stcrozdw 297 18 insect insect NN cord-020235-stcrozdw 297 19 cell cell NN cord-020235-stcrozdw 297 20 cultures culture NNS cord-020235-stcrozdw 297 21 was be VBD cord-020235-stcrozdw 297 22 lowered lower VBN cord-020235-stcrozdw 297 23 by by IN cord-020235-stcrozdw 297 24 approximately approximately RB cord-020235-stcrozdw 297 25 one one CD cord-020235-stcrozdw 297 26 log log NN cord-020235-stcrozdw 297 27 . . . cord-020235-stcrozdw 298 1 No no DT cord-020235-stcrozdw 298 2 influence influence NN cord-020235-stcrozdw 298 3 upon upon IN cord-020235-stcrozdw 298 4 growth growth NN cord-020235-stcrozdw 298 5 or or CC cord-020235-stcrozdw 298 6 morphology morphology NN cord-020235-stcrozdw 298 7 of of IN cord-020235-stcrozdw 298 8 the the DT cord-020235-stcrozdw 298 9 cells cell NNS cord-020235-stcrozdw 298 10 could could MD cord-020235-stcrozdw 298 11 be be VB cord-020235-stcrozdw 298 12 observed observe VBN cord-020235-stcrozdw 298 13 . . . cord-020235-stcrozdw 299 1 The the DT cord-020235-stcrozdw 299 2 gene gene NN cord-020235-stcrozdw 299 3 products product NNS cord-020235-stcrozdw 299 4 of of IN cord-020235-stcrozdw 299 5 replication replication NN cord-020235-stcrozdw 299 6 - - HYPH cord-020235-stcrozdw 299 7 defective defective JJ cord-020235-stcrozdw 299 8 oncornaviruses oncornaviruse NNS cord-020235-stcrozdw 299 9 are be VBP cord-020235-stcrozdw 299 10 high high JJ cord-020235-stcrozdw 299 11 molecular molecular JJ cord-020235-stcrozdw 299 12 weight weight NN cord-020235-stcrozdw 299 13 proteins protein NNS cord-020235-stcrozdw 299 14 which which WDT cord-020235-stcrozdw 299 15 comprise comprise VBP cord-020235-stcrozdw 299 16 a a DT cord-020235-stcrozdw 299 17 gag gag NN cord-020235-stcrozdw 299 18 related relate VBN cord-020235-stcrozdw 299 19 and and CC cord-020235-stcrozdw 299 20 one one CD cord-020235-stcrozdw 299 21 gene gene NN cord-020235-stcrozdw 299 22 product product NN cord-020235-stcrozdw 299 23 . . . cord-020235-stcrozdw 300 1 They -PRON- PRP cord-020235-stcrozdw 300 2 are be VBP cord-020235-stcrozdw 300 3 probably probably RB cord-020235-stcrozdw 300 4 not not RB cord-020235-stcrozdw 300 5 cleaved cleave VBN cord-020235-stcrozdw 300 6 because because IN cord-020235-stcrozdw 300 7 the the DT cord-020235-stcrozdw 300 8 p15 p15 NN cord-020235-stcrozdw 300 9 protease protease NN cord-020235-stcrozdw 300 10 gene gene NN cord-020235-stcrozdw 300 11 is be VBZ cord-020235-stcrozdw 300 12 lacking lack VBG cord-020235-stcrozdw 300 13 . . . cord-020235-stcrozdw 301 1 In in IN cord-020235-stcrozdw 301 2 vitro vitro FW cord-020235-stcrozdw 301 3 , , , cord-020235-stcrozdw 301 4 however however RB cord-020235-stcrozdw 301 5 , , , cord-020235-stcrozdw 301 6 the the DT cord-020235-stcrozdw 301 7 gag gag NN cord-020235-stcrozdw 301 8 - - HYPH cord-020235-stcrozdw 301 9 specific specific JJ cord-020235-stcrozdw 301 10 peptide peptide NN cord-020235-stcrozdw 301 11 sequences sequence NNS cord-020235-stcrozdw 301 12 are be VBP cord-020235-stcrozdw 301 13 cleaved cleave VBN cord-020235-stcrozdw 301 14 off off RP cord-020235-stcrozdw 301 15 upon upon IN cord-020235-stcrozdw 301 16 addition addition NN cord-020235-stcrozdw 301 17 of of IN cord-020235-stcrozdw 301 18 the the DT cord-020235-stcrozdw 301 19 purified purify VBN cord-020235-stcrozdw 301 20 viral viral JJ cord-020235-stcrozdw 301 21 piS pi NNS cord-020235-stcrozdw 301 22 protease protease NN cord-020235-stcrozdw 301 23 ; ; : cord-020235-stcrozdw 301 24 in in IN cord-020235-stcrozdw 301 25 the the DT cord-020235-stcrozdw 301 26 case case NN cord-020235-stcrozdw 301 27 of of IN cord-020235-stcrozdw 301 28 the the DT cord-020235-stcrozdw 301 29 replication replication NN cord-020235-stcrozdw 301 30 - - HYPH cord-020235-stcrozdw 301 31 defective defective JJ cord-020235-stcrozdw 301 32 , , , cord-020235-stcrozdw 301 33 transforming transform VBG cord-020235-stcrozdw 301 34 avian avian JJ cord-020235-stcrozdw 301 35 sarcoma sarcoma NN cord-020235-stcrozdw 301 36 virus virus NN cord-020235-stcrozdw 301 37 PRC PRC NNP cord-020235-stcrozdw 301 38 II II NNP cord-020235-stcrozdw 301 39 the the DT cord-020235-stcrozdw 301 40 cleaved cleaved JJ cord-020235-stcrozdw 301 41 nongag nongag NNP cord-020235-stcrozdw 301 42 part part NN cord-020235-stcrozdw 301 43 has have VBZ cord-020235-stcrozdw 301 44 a a DT cord-020235-stcrozdw 301 45 ryrosine ryrosine JJ cord-020235-stcrozdw 301 46 - - HYPH cord-020235-stcrozdw 301 47 phosphorylaring phosphorylaring NN cord-020235-stcrozdw 301 48 kinase kinase NN cord-020235-stcrozdw 301 49 activity activity NN cord-020235-stcrozdw 301 50 similar similar JJ cord-020235-stcrozdw 301 51 to to IN cord-020235-stcrozdw 301 52 that that DT cord-020235-stcrozdw 301 53 described describe VBN cord-020235-stcrozdw 301 54 for for IN cord-020235-stcrozdw 301 55 the the DT cord-020235-stcrozdw 301 56 RSV RSV NNP cord-020235-stcrozdw 301 57 src src NNP cord-020235-stcrozdw 301 58 - - HYPH cord-020235-stcrozdw 301 59 gene gene NNP cord-020235-stcrozdw 301 60 product product NN cord-020235-stcrozdw 301 61 pp60 pp60 NNP cord-020235-stcrozdw 301 62 src src NNP cord-020235-stcrozdw 301 63 . . . cord-020235-stcrozdw 302 1 Processing processing NN cord-020235-stcrozdw 302 2 of of IN cord-020235-stcrozdw 302 3 Pr92 Pr92 NNP cord-020235-stcrozdw 302 4 gp gp NNP cord-020235-stcrozdw 302 5 , , , cord-020235-stcrozdw 302 6 the the DT cord-020235-stcrozdw 302 7 Precursor Precursor NNP cord-020235-stcrozdw 302 8 to to IN cord-020235-stcrozdw 302 9 the the DT cord-020235-stcrozdw 302 10 Viral Viral NNP cord-020235-stcrozdw 302 11 Glycoproteins Glycoproteins NNPS cord-020235-stcrozdw 302 12 of of IN cord-020235-stcrozdw 302 13 Rous Rous NNP cord-020235-stcrozdw 302 14 Sarcoma Sarcoma NNP cord-020235-stcrozdw 302 15 Virus Virus NNP cord-020235-stcrozdw 302 16 BOSCH BOSCH NNP cord-020235-stcrozdw 302 17 , , , cord-020235-stcrozdw 302 18 V. V. NNP cord-020235-stcrozdw 302 19 , , , cord-020235-stcrozdw 302 20 SCHWARZ SCHWARZ NNP cord-020235-stcrozdw 302 21 , , , cord-020235-stcrozdw 302 22 R. R. NNP cord-020235-stcrozdw 302 23 T. T. NNP cord-020235-stcrozdw 302 24 , , , cord-020235-stcrozdw 302 25 ZIEMIECKI ZIEMIECKI NNP cord-020235-stcrozdw 302 26 , , , cord-020235-stcrozdw 302 27 A. a. NN cord-020235-stcrozdw 302 28 , , , cord-020235-stcrozdw 302 29 and and CC cord-020235-stcrozdw 302 30 FRIIS FRIIS NNP cord-020235-stcrozdw 302 31 , , , cord-020235-stcrozdw 302 32 R. R. NNP cord-020235-stcrozdw 302 33 R. R. NNP cord-020235-stcrozdw 303 1 The the DT cord-020235-stcrozdw 303 2 viral viral JJ cord-020235-stcrozdw 303 3 glycoproteins glycoprotein NNS cord-020235-stcrozdw 303 4 of of IN cord-020235-stcrozdw 303 5 Rous rous JJ cord-020235-stcrozdw 303 6 sarcoma sarcoma NN cord-020235-stcrozdw 303 7 virus virus NN cord-020235-stcrozdw 303 8 gp85 gp85 NNP cord-020235-stcrozdw 303 9 and and CC cord-020235-stcrozdw 303 10 gp35 gp35 NNP cord-020235-stcrozdw 303 11 are be VBP cord-020235-stcrozdw 303 12 synthesized synthesize VBN cord-020235-stcrozdw 303 13 via via IN cord-020235-stcrozdw 303 14 a a DT cord-020235-stcrozdw 303 15 precursor precursor NN cord-020235-stcrozdw 303 16 polyprotein polyprotein NNP cord-020235-stcrozdw 303 17 Pr92 Pr92 NNP cord-020235-stcrozdw 303 18 " " '' cord-020235-stcrozdw 303 19 . . . cord-020235-stcrozdw 304 1 This this DT cord-020235-stcrozdw 304 2 precursor precursor NN cord-020235-stcrozdw 304 3 is be VBZ cord-020235-stcrozdw 304 4 already already RB cord-020235-stcrozdw 304 5 glycosylated glycosylate VBN cord-020235-stcrozdw 304 6 and and CC cord-020235-stcrozdw 304 7 contains contain VBZ cord-020235-stcrozdw 304 8 the the DT cord-020235-stcrozdw 304 9 polypeptides polypeptide NNS cord-020235-stcrozdw 304 10 of of IN cord-020235-stcrozdw 304 11 both both CC cord-020235-stcrozdw 304 12 gp85 gp85 NNP cord-020235-stcrozdw 304 13 and and CC cord-020235-stcrozdw 304 14 gp35 gp35 NNP cord-020235-stcrozdw 304 15 . . . cord-020235-stcrozdw 305 1 We -PRON- PRP cord-020235-stcrozdw 305 2 have have VBP cord-020235-stcrozdw 305 3 studied study VBN cord-020235-stcrozdw 305 4 the the DT cord-020235-stcrozdw 305 5 nature nature NN cord-020235-stcrozdw 305 6 and and CC cord-020235-stcrozdw 305 7 site site NN cord-020235-stcrozdw 305 8 of of IN cord-020235-stcrozdw 305 9 processing processing NN cord-020235-stcrozdw 305 10 of of IN cord-020235-stcrozdw 305 11 Pr92'~to Pr92'~to NNP cord-020235-stcrozdw 305 12 mature mature JJ cord-020235-stcrozdw 305 13 disulfide disulfide RB cord-020235-stcrozdw 305 14 - - HYPH cord-020235-stcrozdw 305 15 linked link VBN cord-020235-stcrozdw 305 16 gp85 gp85 NNP cord-020235-stcrozdw 305 17 and and CC cord-020235-stcrozdw 305 18 gp35 gp35 NNP cord-020235-stcrozdw 305 19 ( ( -LRB- cord-020235-stcrozdw 305 20 VGP VGP NNP cord-020235-stcrozdw 305 21 ) ) -RRB- cord-020235-stcrozdw 305 22 . . . cord-020235-stcrozdw 306 1 We -PRON- PRP cord-020235-stcrozdw 306 2 could could MD cord-020235-stcrozdw 306 3 show show VB cord-020235-stcrozdw 306 4 that that IN cord-020235-stcrozdw 306 5 in in IN cord-020235-stcrozdw 306 6 addition addition NN cord-020235-stcrozdw 306 7 to to IN cord-020235-stcrozdw 306 8 proteolytic proteolytic JJ cord-020235-stcrozdw 306 9 cleavage cleavage NN cord-020235-stcrozdw 306 10 , , , cord-020235-stcrozdw 306 11 processing processing NN cord-020235-stcrozdw 306 12 involves involve VBZ cord-020235-stcrozdw 306 13 conversion conversion NN cord-020235-stcrozdw 306 14 of of IN cord-020235-stcrozdw 306 15 the the DT cord-020235-stcrozdw 306 16 high high JJ cord-020235-stcrozdw 306 17 - - HYPH cord-020235-stcrozdw 306 18 mannose mannose NN cord-020235-stcrozdw 306 19 oligosac oligosac NN cord-020235-stcrozdw 306 20 - - HYPH cord-020235-stcrozdw 306 21 charides charide NNS cord-020235-stcrozdw 306 22 found find VBN cord-020235-stcrozdw 306 23 in in IN cord-020235-stcrozdw 306 24 Pr92 Pr92 NNP cord-020235-stcrozdw 306 25 ' ' POS cord-020235-stcrozdw 306 26 " " '' cord-020235-stcrozdw 306 27 to to IN cord-020235-stcrozdw 306 28 the the DT cord-020235-stcrozdw 306 29 complex complex JJ cord-020235-stcrozdw 306 30 , , , cord-020235-stcrozdw 306 31 sialidated sialidated JJ cord-020235-stcrozdw 306 32 oligosaccharides oligosaccharide NNS cord-020235-stcrozdw 306 33 found find VBN cord-020235-stcrozdw 306 34 in in IN cord-020235-stcrozdw 306 35 VGP VGP NNP cord-020235-stcrozdw 306 36 . . . cord-020235-stcrozdw 307 1 Experiments experiment NNS cord-020235-stcrozdw 307 2 pertaining pertain VBG cord-020235-stcrozdw 307 3 to to IN cord-020235-stcrozdw 307 4 the the DT cord-020235-stcrozdw 307 5 site site NN cord-020235-stcrozdw 307 6 of of IN cord-020235-stcrozdw 307 7 processing processing NN cord-020235-stcrozdw 307 8 indicate indicate VBP cord-020235-stcrozdw 307 9 that that IN cord-020235-stcrozdw 307 10 processing processing NN cord-020235-stcrozdw 307 11 does do VBZ cord-020235-stcrozdw 307 12 not not RB cord-020235-stcrozdw 307 13 occur occur VB cord-020235-stcrozdw 307 14 extracellularly extracellularly RB cord-020235-stcrozdw 307 15 as as IN cord-020235-stcrozdw 307 16 has have VBZ cord-020235-stcrozdw 307 17 been be VBN cord-020235-stcrozdw 307 18 proposed propose VBN cord-020235-stcrozdw 307 19 by by IN cord-020235-stcrozdw 307 20 others other NNS cord-020235-stcrozdw 307 21 iKlemenz iKlemenz NNP cord-020235-stcrozdw 307 22 and and CC cord-020235-stcrozdw 307 23 Diggelmann Diggelmann NNP cord-020235-stcrozdw 307 24 , , , cord-020235-stcrozdw 307 25 J. J. NNP cord-020235-stcrozdw 307 26 Virol Virol NNP cord-020235-stcrozdw 307 27 . . . cord-020235-stcrozdw 308 1 29 29 CD cord-020235-stcrozdw 308 2 ( ( -LRB- cord-020235-stcrozdw 308 3 1979 1979 CD cord-020235-stcrozdw 308 4 ) ) -RRB- cord-020235-stcrozdw 309 1 285 285 CD cord-020235-stcrozdw 309 2 - - SYM cord-020235-stcrozdw 309 3 292 292 CD cord-020235-stcrozdw 309 4 . . . cord-020235-stcrozdw 310 1 We -PRON- PRP cord-020235-stcrozdw 310 2 have have VBP cord-020235-stcrozdw 310 3 determined determine VBN cord-020235-stcrozdw 310 4 that that IN cord-020235-stcrozdw 310 5 the the DT cord-020235-stcrozdw 310 6 small small JJ cord-020235-stcrozdw 310 7 amount amount NN cord-020235-stcrozdw 310 8 of of IN cord-020235-stcrozdw 310 9 mature mature JJ cord-020235-stcrozdw 310 10 VGP VGP NNP cord-020235-stcrozdw 310 11 found find VBD cord-020235-stcrozdw 310 12 in in IN cord-020235-stcrozdw 310 13 infected infected JJ cord-020235-stcrozdw 310 14 cell cell NN cord-020235-stcrozdw 310 15 lysates lysate NNS cord-020235-stcrozdw 310 16 is be VBZ cord-020235-stcrozdw 310 17 localized localize VBN cord-020235-stcrozdw 310 18 chiefly chiefly RB cord-020235-stcrozdw 310 19 within within IN cord-020235-stcrozdw 310 20 the the DT cord-020235-stcrozdw 310 21 cell cell NN cord-020235-stcrozdw 310 22 , , , cord-020235-stcrozdw 310 23 not not RB cord-020235-stcrozdw 310 24 at at IN cord-020235-stcrozdw 310 25 the the DT cord-020235-stcrozdw 310 26 cell cell NN cord-020235-stcrozdw 310 27 surface surface NN cord-020235-stcrozdw 310 28 . . . cord-020235-stcrozdw 311 1 We -PRON- PRP cord-020235-stcrozdw 311 2 favour favour VBP cord-020235-stcrozdw 311 3 the the DT cord-020235-stcrozdw 311 4 view view NN cord-020235-stcrozdw 311 5 that that IN cord-020235-stcrozdw 311 6 further further JJ cord-020235-stcrozdw 311 7 glycosylation glycosylation NN cord-020235-stcrozdw 311 8 and and CC cord-020235-stcrozdw 311 9 proteolytic proteolytic JJ cord-020235-stcrozdw 311 10 cleavage cleavage NN cord-020235-stcrozdw 311 11 occur occur VBP cord-020235-stcrozdw 311 12 concomitantly concomitantly RB cord-020235-stcrozdw 311 13 on on IN cord-020235-stcrozdw 311 14 smooth smooth JJ cord-020235-stcrozdw 311 15 membranes membrane NNS cord-020235-stcrozdw 311 16 within within IN cord-020235-stcrozdw 311 17 the the DT cord-020235-stcrozdw 311 18 cell cell NN cord-020235-stcrozdw 311 19 and and CC cord-020235-stcrozdw 311 20 that that DT cord-020235-stcrozdw 311 21 subsequent subsequent JJ cord-020235-stcrozdw 311 22 to to IN cord-020235-stcrozdw 311 23 this this DT cord-020235-stcrozdw 311 24 , , , cord-020235-stcrozdw 311 25 export export NN cord-020235-stcrozdw 311 26 in in IN cord-020235-stcrozdw 311 27 virus virus NN cord-020235-stcrozdw 311 28 is be VBZ cord-020235-stcrozdw 311 29 rapid rapid JJ cord-020235-stcrozdw 311 30 . . . cord-020235-stcrozdw 312 1 1 1 LS cord-020235-stcrozdw 313 1 Paul Paul NNP cord-020235-stcrozdw 313 2 - - HYPH cord-020235-stcrozdw 313 3 Ehrlich Ehrlich NNP cord-020235-stcrozdw 313 4 - - HYPH cord-020235-stcrozdw 313 5 Inst Inst NNP cord-020235-stcrozdw 313 6 . . . cord-020235-stcrozdw 314 1 , , , cord-020235-stcrozdw 314 2 D-6000 d-6000 CD cord-020235-stcrozdw 314 3 Frankfurt Frankfurt NNP cord-020235-stcrozdw 314 4 ; ; : cord-020235-stcrozdw 314 5 2 2 CD cord-020235-stcrozdw 314 6 lnst lnst NN cord-020235-stcrozdw 314 7 . . . cord-020235-stcrozdw 315 1 f. f. NNP cord-020235-stcrozdw 315 2 Virologie Virologie NNP cord-020235-stcrozdw 315 3 , , , cord-020235-stcrozdw 315 4 Univ Univ NNP cord-020235-stcrozdw 315 5 . . NNP cord-020235-stcrozdw 315 6 , , , cord-020235-stcrozdw 316 1 D·6300 D·6300 NNP cord-020235-stcrozdw 316 2 Giefen Giefen NNP cord-020235-stcrozdw 316 3 , , , cord-020235-stcrozdw 316 4 3 3 CD cord-020235-stcrozdw 316 5 A a DT cord-020235-stcrozdw 316 6 protein protein NN cord-020235-stcrozdw 316 7 of of IN cord-020235-stcrozdw 316 8 a a DT cord-020235-stcrozdw 316 9 molecular molecular JJ cord-020235-stcrozdw 316 10 weight weight NN cord-020235-stcrozdw 316 11 of of IN cord-020235-stcrozdw 316 12 about about IN cord-020235-stcrozdw 316 13 38.000 38.000 CD cord-020235-stcrozdw 316 14 d d NN cord-020235-stcrozdw 316 15 has have VBZ cord-020235-stcrozdw 316 16 been be VBN cord-020235-stcrozdw 316 17 found find VBN cord-020235-stcrozdw 316 18 to to TO cord-020235-stcrozdw 316 19 be be VB cord-020235-stcrozdw 316 20 phosphorylated phosphorylate VBN cord-020235-stcrozdw 316 21 1 1 CD cord-020235-stcrozdw 316 22 h h NN cord-020235-stcrozdw 316 23 after after IN cord-020235-stcrozdw 316 24 the the DT cord-020235-stcrozdw 316 25 onset onset NN cord-020235-stcrozdw 316 26 of of IN cord-020235-stcrozdw 316 27 cell cell NN cord-020235-stcrozdw 316 28 transformation transformation NN cord-020235-stcrozdw 316 29 by by IN cord-020235-stcrozdw 316 30 Rous rous JJ cord-020235-stcrozdw 316 31 sarcoma sarcoma NN cord-020235-stcrozdw 316 32 virus virus NN cord-020235-stcrozdw 316 33 ( ( -LRB- cord-020235-stcrozdw 316 34 RSV RSV NNP cord-020235-stcrozdw 316 35 ) ) -RRB- cord-020235-stcrozdw 316 36 . . . cord-020235-stcrozdw 317 1 It -PRON- PRP cord-020235-stcrozdw 317 2 is be VBZ cord-020235-stcrozdw 317 3 assumed assume VBN cord-020235-stcrozdw 317 4 to to TO cord-020235-stcrozdw 317 5 be be VB cord-020235-stcrozdw 317 6 a a DT cord-020235-stcrozdw 317 7 physiological physiological JJ cord-020235-stcrozdw 317 8 target target NN cord-020235-stcrozdw 317 9 of of IN cord-020235-stcrozdw 317 10 the the DT cord-020235-stcrozdw 317 11 pp60 pp60 NNP cord-020235-stcrozdw 317 12 ' ' POS cord-020235-stcrozdw 317 13 " " `` cord-020235-stcrozdw 317 14 kinase kinase NN cord-020235-stcrozdw 317 15 , , , cord-020235-stcrozdw 317 16 since since IN cord-020235-stcrozdw 317 17 , , , cord-020235-stcrozdw 317 18 apart apart RB cord-020235-stcrozdw 317 19 from from IN cord-020235-stcrozdw 317 20 being be VBG cord-020235-stcrozdw 317 21 phosphorylated phosphorylate VBN cord-020235-stcrozdw 317 22 in in IN cord-020235-stcrozdw 317 23 the the DT cord-020235-stcrozdw 317 24 transformed transformed JJ cord-020235-stcrozdw 317 25 cell cell NN cord-020235-stcrozdw 317 26 , , , cord-020235-stcrozdw 317 27 it -PRON- PRP cord-020235-stcrozdw 317 28 can can MD cord-020235-stcrozdw 317 29 be be VB cord-020235-stcrozdw 317 30 phosphorylated phosphorylate VBN cord-020235-stcrozdw 317 31 in in IN cord-020235-stcrozdw 317 32 vitro vitro FW cord-020235-stcrozdw 317 33 by by IN cord-020235-stcrozdw 317 34 the the DT cord-020235-stcrozdw 317 35 pp60 pp60 NNP cord-020235-stcrozdw 317 36 " " '' cord-020235-stcrozdw 318 1 · · NFP cord-020235-stcrozdw 318 2 kinase kinase NN cord-020235-stcrozdw 318 3 in in IN cord-020235-stcrozdw 318 4 tyrosine tyrosine NN cord-020235-stcrozdw 318 5 ( ( -LRB- cord-020235-stcrozdw 318 6 1 1 CD cord-020235-stcrozdw 318 7 , , , cord-020235-stcrozdw 318 8 2 2 CD cord-020235-stcrozdw 318 9 ) ) -RRB- cord-020235-stcrozdw 318 10 . . . cord-020235-stcrozdw 319 1 -Using -use VBG cord-020235-stcrozdw 319 2 6 6 CD cord-020235-stcrozdw 319 3 different different JJ cord-020235-stcrozdw 319 4 chromatographic chromatographic JJ cord-020235-stcrozdw 319 5 procedures procedure NNS cord-020235-stcrozdw 319 6 ( ( -LRB- cord-020235-stcrozdw 319 7 chromatography chromatography NN cord-020235-stcrozdw 319 8 on on IN cord-020235-stcrozdw 319 9 DEAE DEAE NNP cord-020235-stcrozdw 319 10 - - HYPH cord-020235-stcrozdw 319 11 Sephacel Sephacel NNP cord-020235-stcrozdw 319 12 , , , cord-020235-stcrozdw 319 13 poly poly NNP cord-020235-stcrozdw 319 14 ( ( -LRB- cord-020235-stcrozdw 319 15 A)-Sepharose A)-Sepharose NNP cord-020235-stcrozdw 319 16 , , , cord-020235-stcrozdw 319 17 Blue Blue NNP cord-020235-stcrozdw 319 18 Sepharose Sepharose NNP cord-020235-stcrozdw 319 19 , , , cord-020235-stcrozdw 319 20 and and CC cord-020235-stcrozdw 319 21 hydroxylapatite hydroxylapatite NN cord-020235-stcrozdw 319 22 , , , cord-020235-stcrozdw 319 23 isoelectric isoelectric JJ cord-020235-stcrozdw 319 24 focusing focus VBG cord-020235-stcrozdw 319 25 and and CC cord-020235-stcrozdw 319 26 gel gel NN cord-020235-stcrozdw 319 27 filtration filtration NN cord-020235-stcrozdw 319 28 ) ) -RRB- cord-020235-stcrozdw 320 1 the the DT cord-020235-stcrozdw 320 2 38,000 38,000 CD cord-020235-stcrozdw 320 3 d d NN cord-020235-stcrozdw 320 4 protein protein NN cord-020235-stcrozdw 320 5 could could MD cord-020235-stcrozdw 320 6 not not RB cord-020235-stcrozdw 320 7 be be VB cord-020235-stcrozdw 320 8 separated separate VBN cord-020235-stcrozdw 320 9 from from IN cord-020235-stcrozdw 320 10 cytosolic cytosolic JJ cord-020235-stcrozdw 320 11 malic malic JJ cord-020235-stcrozdw 320 12 dehydrogenase dehydrogenase NN cord-020235-stcrozdw 320 13 activity activity NN cord-020235-stcrozdw 320 14 ( ( -LRB- cord-020235-stcrozdw 320 15 c c NNP cord-020235-stcrozdw 320 16 - - HYPH cord-020235-stcrozdw 320 17 M M NNP cord-020235-stcrozdw 320 18 DH DH NNP cord-020235-stcrozdw 320 19 ) ) -RRB- cord-020235-stcrozdw 320 20 . . . cord-020235-stcrozdw 321 1 Antiserum Antiserum NNP cord-020235-stcrozdw 321 2 against against IN cord-020235-stcrozdw 321 3 the the DT cord-020235-stcrozdw 321 4 38,000 38,000 CD cord-020235-stcrozdw 321 5 d d NN cord-020235-stcrozdw 321 6 protein protein NN cord-020235-stcrozdw 321 7 inhibited inhibit VBN cord-020235-stcrozdw 321 8 c c NNP cord-020235-stcrozdw 321 9 - - HYPH cord-020235-stcrozdw 321 10 MDH MDH NNP cord-020235-stcrozdw 321 11 . . . cord-020235-stcrozdw 322 1 The the DT cord-020235-stcrozdw 322 2 Transformation transformation NN cord-020235-stcrozdw 322 3 - - HYPH cord-020235-stcrozdw 322 4 specific specific JJ cord-020235-stcrozdw 322 5 Protein Protein NNP cord-020235-stcrozdw 322 6 " " '' cord-020235-stcrozdw 322 7 v v NNP cord-020235-stcrozdw 322 8 - - HYPH cord-020235-stcrozdw 322 9 myc myc NNP cord-020235-stcrozdw 322 10 " " '' cord-020235-stcrozdw 322 11 of of IN cord-020235-stcrozdw 322 12 the the DT cord-020235-stcrozdw 322 13 Acute acute JJ cord-020235-stcrozdw 322 14 Avian Avian NNP cord-020235-stcrozdw 322 15 Leukemia Leukemia NNP cord-020235-stcrozdw 322 16 Virus Virus NNP cord-020235-stcrozdw 322 17 MC29 MC29 NNP cord-020235-stcrozdw 322 18 DONNER DONNER NNP cord-020235-stcrozdw 322 19 , , , cord-020235-stcrozdw 322 20 P. P. NNP cord-020235-stcrozdw 322 21 , , , cord-020235-stcrozdw 322 22 GREISER GREISER NNP cord-020235-stcrozdw 322 23 - - HYPH cord-020235-stcrozdw 322 24 WILKE WILKE NNP cord-020235-stcrozdw 322 25 , , , cord-020235-stcrozdw 322 26 IRENE IRENE NNP cord-020235-stcrozdw 322 27 , , , cord-020235-stcrozdw 322 28 and and CC cord-020235-stcrozdw 322 29 MOELLING MOELLING NNP cord-020235-stcrozdw 322 30 , , , cord-020235-stcrozdw 322 31 KARIN KARIN NNP cord-020235-stcrozdw 322 32 Avian avian JJ cord-020235-stcrozdw 322 33 acute acute JJ cord-020235-stcrozdw 322 34 leukemia leukemia NN cord-020235-stcrozdw 322 35 viruses virus NNS cord-020235-stcrozdw 322 36 transform transform VBP cord-020235-stcrozdw 322 37 cells cell NNS cord-020235-stcrozdw 322 38 through through IN cord-020235-stcrozdw 322 39 a a DT cord-020235-stcrozdw 322 40 virus virus NN cord-020235-stcrozdw 322 41 - - HYPH cord-020235-stcrozdw 322 42 coded code VBN cord-020235-stcrozdw 322 43 oncogene oncogene NN cord-020235-stcrozdw 322 44 . . . cord-020235-stcrozdw 323 1 In in IN cord-020235-stcrozdw 323 2 the the DT cord-020235-stcrozdw 323 3 case case NN cord-020235-stcrozdw 323 4 of of IN cord-020235-stcrozdw 323 5 the the DT cord-020235-stcrozdw 323 6 rnyelocytornatosis rnyelocytornatosis NN cord-020235-stcrozdw 323 7 virus virus NN cord-020235-stcrozdw 323 8 , , , cord-020235-stcrozdw 323 9 MC29 MC29 NNP cord-020235-stcrozdw 323 10 , , , cord-020235-stcrozdw 323 11 which which WDT cord-020235-stcrozdw 323 12 transforms transform VBZ cord-020235-stcrozdw 323 13 fibroblasts fibroblast NNS cord-020235-stcrozdw 323 14 as as RB cord-020235-stcrozdw 323 15 well well RB cord-020235-stcrozdw 323 16 as as IN cord-020235-stcrozdw 323 17 bone bone NN cord-020235-stcrozdw 323 18 marrow marrow NN cord-020235-stcrozdw 323 19 cells cell NNS cord-020235-stcrozdw 323 20 in in IN cord-020235-stcrozdw 323 21 vitro vitro FW cord-020235-stcrozdw 323 22 , , , cord-020235-stcrozdw 323 23 this this DT cord-020235-stcrozdw 323 24 oncogene oncogene NN cord-020235-stcrozdw 323 25 is be VBZ cord-020235-stcrozdw 323 26 fused fuse VBN cord-020235-stcrozdw 323 27 to to IN cord-020235-stcrozdw 323 28 a a DT cord-020235-stcrozdw 323 29 viral viral JJ cord-020235-stcrozdw 323 30 structural structural JJ cord-020235-stcrozdw 323 31 component component NN cord-020235-stcrozdw 323 32 , , , cord-020235-stcrozdw 323 33 p19 p19 NN cord-020235-stcrozdw 323 34 . . . cord-020235-stcrozdw 324 1 The the DT cord-020235-stcrozdw 324 2 fusion fusion NN cord-020235-stcrozdw 324 3 protein protein NN cord-020235-stcrozdw 324 4 , , , cord-020235-stcrozdw 324 5 v v NN cord-020235-stcrozdw 324 6 - - NN cord-020235-stcrozdw 324 7 rnyc rnyc NNP cord-020235-stcrozdw 324 8 , , , cord-020235-stcrozdw 324 9 was be VBD cord-020235-stcrozdw 324 10 characterized characterize VBN cord-020235-stcrozdw 324 11 by by IN cord-020235-stcrozdw 324 12 using use VBG cord-020235-stcrozdw 324 13 monoclonal monoclonal JJ cord-020235-stcrozdw 324 14 antibodies antibody NNS cord-020235-stcrozdw 324 15 against against IN cord-020235-stcrozdw 324 16 p19 p19 NN cord-020235-stcrozdw 324 17 . . . cord-020235-stcrozdw 325 1 MC29 MC29 NNP cord-020235-stcrozdw 325 2 transformed transform VBD cord-020235-stcrozdw 325 3 quail quail NN cord-020235-stcrozdw 325 4 fibroblasts fibroblast NNS cord-020235-stcrozdw 325 5 which which WDT cord-020235-stcrozdw 325 6 do do VBP cord-020235-stcrozdw 325 7 not not RB cord-020235-stcrozdw 325 8 produce produce VB cord-020235-stcrozdw 325 9 any any DT cord-020235-stcrozdw 325 10 virus virus NN cord-020235-stcrozdw 325 11 , , , cord-020235-stcrozdw 325 12 MC29-Q8 MC29-Q8 NNP cord-020235-stcrozdw 325 13 , , , cord-020235-stcrozdw 325 14 were be VBD cord-020235-stcrozdw 325 15 analyzed analyze VBN cord-020235-stcrozdw 325 16 b b NNP cord-020235-stcrozdw 325 17 y y NNP cord-020235-stcrozdw 325 18 immunofluorescence immunofluorescence NN cord-020235-stcrozdw 325 19 . . . cord-020235-stcrozdw 326 1 A a DT cord-020235-stcrozdw 326 2 nuclear nuclear JJ cord-020235-stcrozdw 326 3 fluorescence fluorescence NN cord-020235-stcrozdw 326 4 was be VBD cord-020235-stcrozdw 326 5 observed observe VBN cord-020235-stcrozdw 326 6 which which WDT cord-020235-stcrozdw 326 7 was be VBD cord-020235-stcrozdw 326 8 not not RB cord-020235-stcrozdw 326 9 detected detect VBN cord-020235-stcrozdw 326 10 in in IN cord-020235-stcrozdw 326 11 normal normal JJ cord-020235-stcrozdw 326 12 cells cell NNS cord-020235-stcrozdw 326 13 or or CC cord-020235-stcrozdw 326 14 virus virus NN cord-020235-stcrozdw 326 15 - - HYPH cord-020235-stcrozdw 326 16 producing produce VBG cord-020235-stcrozdw 326 17 cells cell NNS cord-020235-stcrozdw 326 18 . . . cord-020235-stcrozdw 327 1 The the DT cord-020235-stcrozdw 327 2 monoclonal monoclonal JJ cord-020235-stcrozdw 327 3 antibodies antibody NNS cord-020235-stcrozdw 327 4 were be VBD cord-020235-stcrozdw 327 5 used use VBN cord-020235-stcrozdw 327 6 to to TO cord-020235-stcrozdw 327 7 purify purify VB cord-020235-stcrozdw 327 8 the the DT cord-020235-stcrozdw 327 9 v v NNP cord-020235-stcrozdw 327 10 - - HYPH cord-020235-stcrozdw 327 11 myc myc NNP cord-020235-stcrozdw 327 12 protein protein NN cord-020235-stcrozdw 327 13 by by IN cord-020235-stcrozdw 327 14 immuno immuno JJ cord-020235-stcrozdw 327 15 - - JJ cord-020235-stcrozdw 327 16 affinity affinity JJ cord-020235-stcrozdw 327 17 chromatography chromatography NN cord-020235-stcrozdw 327 18 . . . cord-020235-stcrozdw 328 1 The the DT cord-020235-stcrozdw 328 2 purification purification NN cord-020235-stcrozdw 328 3 achieved achieve VBN cord-020235-stcrozdw 328 4 by by IN cord-020235-stcrozdw 328 5 this this DT cord-020235-stcrozdw 328 6 single single JJ cord-020235-stcrozdw 328 7 - - HYPH cord-020235-stcrozdw 328 8 step step NN cord-020235-stcrozdw 328 9 purification purification NN cord-020235-stcrozdw 328 10 was be VBD cord-020235-stcrozdw 328 11 3,500 3,500 CD cord-020235-stcrozdw 328 12 fold fold NN cord-020235-stcrozdw 328 13 . . . cord-020235-stcrozdw 329 1 The the DT cord-020235-stcrozdw 329 2 eluted eluted JJ cord-020235-stcrozdw 329 3 protein protein NN cord-020235-stcrozdw 329 4 was be VBD cord-020235-stcrozdw 329 5 precipitable precipitable JJ cord-020235-stcrozdw 329 6 by by IN cord-020235-stcrozdw 329 7 anti anti JJ cord-020235-stcrozdw 329 8 - - JJ cord-020235-stcrozdw 329 9 sera sera JJ cord-020235-stcrozdw 329 10 and and CC cord-020235-stcrozdw 329 11 will will MD cord-020235-stcrozdw 329 12 be be VB cord-020235-stcrozdw 329 13 further further RB cord-020235-stcrozdw 329 14 characterized characterize VBN cord-020235-stcrozdw 329 15 for for IN cord-020235-stcrozdw 329 16 its -PRON- PRP$ cord-020235-stcrozdw 329 17 biological biological JJ cord-020235-stcrozdw 329 18 properties property NNS cord-020235-stcrozdw 329 19 . . . cord-020235-stcrozdw 330 1 Med Med NNP cord-020235-stcrozdw 330 2 . . . cord-020235-stcrozdw 331 1 Poliklinik Poliklinik NNP cord-020235-stcrozdw 331 2 , , , cord-020235-stcrozdw 331 3 Univ Univ NNP cord-020235-stcrozdw 331 4 . . NNP cord-020235-stcrozdw 331 5 , , , cord-020235-stcrozdw 332 1 D-8000 D-8000 NNP cord-020235-stcrozdw 333 1 Miinchen Miinchen NNP cord-020235-stcrozdw 333 2 ; ; : cord-020235-stcrozdw 333 3 Abr Abr NNP cord-020235-stcrozdw 333 4 , , , cord-020235-stcrozdw 333 5 f. f. NNP cord-020235-stcrozdw 333 6 Pathologie Pathologie NNP cord-020235-stcrozdw 333 7 d. d. NNP cord-020235-stcrozdw 333 8 GSF GSF NNP cord-020235-stcrozdw 333 9 , , , cord-020235-stcrozdw 333 10 Neuherberg Neuherberg NNP cord-020235-stcrozdw 333 11 Biochemical Biochemical NNP cord-020235-stcrozdw 333 12 Characterization characterization NN cord-020235-stcrozdw 333 13 of of IN cord-020235-stcrozdw 333 14 Antigens Antigens NNPS cord-020235-stcrozdw 333 15 in in IN cord-020235-stcrozdw 333 16 Human Human NNP cord-020235-stcrozdw 333 17 Leukemic Leukemic NNP cord-020235-stcrozdw 333 18 Sera Sera NNP cord-020235-stcrozdw 333 19 that that IN cord-020235-stcrozdw 333 20 Crossreact Crossreact NNP cord-020235-stcrozdw 333 21 with with IN cord-020235-stcrozdw 333 22 SiSV SiSV NNP cord-020235-stcrozdw 333 23 p30 p30 NNP cord-020235-stcrozdw 333 24 and and CC cord-020235-stcrozdw 333 25 BAEVp30 BAEVp30 NNP cord-020235-stcrozdw 333 26 LEIB LEIB NNP cord-020235-stcrozdw 333 27 , , , cord-020235-stcrozdw 333 28 c. c. NN cord-020235-stcrozdw 333 29 , , , cord-020235-stcrozdw 333 30 SCHETTERS SCHETTERS NNP cord-020235-stcrozdw 333 31 , , , cord-020235-stcrozdw 333 32 H. H. NNP cord-020235-stcrozdw 333 33 , , , cord-020235-stcrozdw 333 34 ERFLE ERFLE NNP cord-020235-stcrozdw 333 35 , , , cord-020235-stcrozdw 333 36 V. V. NNP cord-020235-stcrozdw 333 37 , , , cord-020235-stcrozdw 333 38 and and CC cord-020235-stcrozdw 333 39 HEHLMANN HEHLMANN NNP cord-020235-stcrozdw 333 40 , , , cord-020235-stcrozdw 334 1 R. R. NNP cord-020235-stcrozdw 334 2 Antigens Antigens NNP cord-020235-stcrozdw 334 3 crossreacting crossreacte VBG cord-020235-stcrozdw 334 4 with with IN cord-020235-stcrozdw 334 5 the the DT cord-020235-stcrozdw 334 6 core core NN cord-020235-stcrozdw 334 7 proteins protein NNS cord-020235-stcrozdw 334 8 p30 p30 NN cord-020235-stcrozdw 334 9 of of IN cord-020235-stcrozdw 334 10 baboon baboon NN cord-020235-stcrozdw 334 11 endogenous endogenous JJ cord-020235-stcrozdw 334 12 virus virus NN cord-020235-stcrozdw 334 13 ( ( -LRB- cord-020235-stcrozdw 334 14 BaEV BaEV NNP cord-020235-stcrozdw 334 15 ) ) -RRB- cord-020235-stcrozdw 334 16 and/or and/or CC cord-020235-stcrozdw 334 17 of of IN cord-020235-stcrozdw 334 18 simian simian JJ cord-020235-stcrozdw 334 19 sarcoma sarcoma NN cord-020235-stcrozdw 334 20 associated associate VBN cord-020235-stcrozdw 334 21 virus virus NN cord-020235-stcrozdw 334 22 ( ( -LRB- cord-020235-stcrozdw 334 23 SiSV SiSV NNP cord-020235-stcrozdw 334 24 ) ) -RRB- cord-020235-stcrozdw 334 25 have have VBP cord-020235-stcrozdw 334 26 been be VBN cord-020235-stcrozdw 334 27 isolated isolate VBN cord-020235-stcrozdw 334 28 from from IN cord-020235-stcrozdw 334 29 human human JJ cord-020235-stcrozdw 334 30 leukemic leukemic JJ cord-020235-stcrozdw 334 31 sera sera NNP cord-020235-stcrozdw 334 32 by by IN cord-020235-stcrozdw 334 33 immunoaffinity immunoaffinity NN cord-020235-stcrozdw 334 34 chromatography chromatography NN cord-020235-stcrozdw 334 35 . . . cord-020235-stcrozdw 335 1 The the DT cord-020235-stcrozdw 335 2 antigens antigen NNS cord-020235-stcrozdw 335 3 have have VBP cord-020235-stcrozdw 335 4 an an DT cord-020235-stcrozdw 335 5 apparent apparent JJ cord-020235-stcrozdw 335 6 molecular molecular JJ cord-020235-stcrozdw 335 7 weight weight NN cord-020235-stcrozdw 335 8 of of IN cord-020235-stcrozdw 335 9 70,000 70,000 CD cord-020235-stcrozdw 335 10 in in IN cord-020235-stcrozdw 335 11 SDS SDS NNP cord-020235-stcrozdw 335 12 - - HYPH cord-020235-stcrozdw 335 13 polyacrylamide polyacrylamide NN cord-020235-stcrozdw 335 14 gel gel NN cord-020235-stcrozdw 335 15 electrophoresis electrophoresis NN cord-020235-stcrozdw 335 16 . . . cord-020235-stcrozdw 336 1 Peptide peptide NN cord-020235-stcrozdw 336 2 maps map NNS cord-020235-stcrozdw 336 3 performed perform VBN cord-020235-stcrozdw 336 4 with with IN cord-020235-stcrozdw 336 5 the the DT cord-020235-stcrozdw 336 6 antigens antigen NNS cord-020235-stcrozdw 336 7 from from IN cord-020235-stcrozdw 336 8 two two CD cord-020235-stcrozdw 336 9 different different JJ cord-020235-stcrozdw 336 10 leukemic leukemic JJ cord-020235-stcrozdw 336 11 sera sera NNP cord-020235-stcrozdw 336 12 show show VBP cord-020235-stcrozdw 336 13 that that IN cord-020235-stcrozdw 336 14 the the DT cord-020235-stcrozdw 336 15 two two CD cord-020235-stcrozdw 336 16 antigens antigen NNS cord-020235-stcrozdw 336 17 are be VBP cord-020235-stcrozdw 336 18 identical identical JJ cord-020235-stcrozdw 336 19 . . . cord-020235-stcrozdw 337 1 Peptide peptide NN cord-020235-stcrozdw 337 2 analyses analysis NNS cord-020235-stcrozdw 337 3 of of IN cord-020235-stcrozdw 337 4 SiSV SiSV NNP cord-020235-stcrozdw 337 5 p30 p30 NNP cord-020235-stcrozdw 337 6 and and CC cord-020235-stcrozdw 337 7 of of IN cord-020235-stcrozdw 337 8 BaEV BaEV NNP cord-020235-stcrozdw 337 9 p30 p30 NNP cord-020235-stcrozdw 337 10 and and CC cord-020235-stcrozdw 337 11 simultaneous simultaneous JJ cord-020235-stcrozdw 337 12 mapping mapping NN cord-020235-stcrozdw 337 13 of of IN cord-020235-stcrozdw 337 14 p30 p30 NNP cord-020235-stcrozdw 337 15 proteins protein NNS cord-020235-stcrozdw 337 16 mixed mix VBN cord-020235-stcrozdw 337 17 with with IN cord-020235-stcrozdw 337 18 human human JJ cord-020235-stcrozdw 337 19 antigens antigen NNS cord-020235-stcrozdw 337 20 show show VBP cord-020235-stcrozdw 337 21 that that IN cord-020235-stcrozdw 337 22 11 11 CD cord-020235-stcrozdw 337 23 out out IN cord-020235-stcrozdw 337 24 of of IN cord-020235-stcrozdw 337 25 21 21 CD cord-020235-stcrozdw 337 26 major major JJ cord-020235-stcrozdw 337 27 peptides peptide NNS cord-020235-stcrozdw 337 28 of of IN cord-020235-stcrozdw 337 29 SiSV SiSV NNP cord-020235-stcrozdw 337 30 p30 p30 NNP cord-020235-stcrozdw 337 31 and and CC cord-020235-stcrozdw 337 32 10 10 CD cord-020235-stcrozdw 337 33 out out IN cord-020235-stcrozdw 337 34 of of IN cord-020235-stcrozdw 337 35 20 20 CD cord-020235-stcrozdw 337 36 major major JJ cord-020235-stcrozdw 337 37 peptides peptide NNS cord-020235-stcrozdw 337 38 of of IN cord-020235-stcrozdw 337 39 BaEV BaEV NNP cord-020235-stcrozdw 337 40 p30 p30 NNP cord-020235-stcrozdw 337 41 have have VBP cord-020235-stcrozdw 337 42 identical identical JJ cord-020235-stcrozdw 337 43 mobility mobility NN cord-020235-stcrozdw 337 44 with with IN cord-020235-stcrozdw 337 45 peptides peptide NNS cord-020235-stcrozdw 337 46 of of IN cord-020235-stcrozdw 337 47 the the DT cord-020235-stcrozdw 337 48 human human JJ cord-020235-stcrozdw 337 49 antigens antigen NNS cord-020235-stcrozdw 337 50 . . . cord-020235-stcrozdw 338 1 Human human JJ cord-020235-stcrozdw 338 2 serum serum NN cord-020235-stcrozdw 338 3 albumin albumin NN cord-020235-stcrozdw 338 4 , , , cord-020235-stcrozdw 338 5 transferrin transferrin NN cord-020235-stcrozdw 338 6 , , , cord-020235-stcrozdw 338 7 fibrinogen fibrinogen NN cord-020235-stcrozdw 338 8 , , , cord-020235-stcrozdw 338 9 IgG IgG NNP cord-020235-stcrozdw 338 10 and and CC cord-020235-stcrozdw 338 11 IgM IgM NNP cord-020235-stcrozdw 338 12 share share VBP cord-020235-stcrozdw 338 13 clearly clearly RB cord-020235-stcrozdw 338 14 less less JJR cord-020235-stcrozdw 338 15 peptides peptide NNS cord-020235-stcrozdw 338 16 of of IN cord-020235-stcrozdw 338 17 identical identical JJ cord-020235-stcrozdw 338 18 mobility mobility NN cord-020235-stcrozdw 338 19 with with IN cord-020235-stcrozdw 338 20 the the DT cord-020235-stcrozdw 338 21 human human JJ cord-020235-stcrozdw 338 22 antigens antigen NNS cord-020235-stcrozdw 338 23 . . . cord-020235-stcrozdw 339 1 The the DT cord-020235-stcrozdw 339 2 isoglycoproteins isoglycoprotein NNS cord-020235-stcrozdw 339 3 gp69 gp69 NNPS cord-020235-stcrozdw 339 4 and and CC cord-020235-stcrozdw 339 5 gp71 gp71 NNP cord-020235-stcrozdw 339 6 were be VBD cord-020235-stcrozdw 339 7 purified purify VBN cord-020235-stcrozdw 339 8 from from IN cord-020235-stcrozdw 339 9 F F NNP cord-020235-stcrozdw 339 10 - - HYPH cord-020235-stcrozdw 339 11 MuLV MuLV NNP cord-020235-stcrozdw 339 12 particles particle NNS cord-020235-stcrozdw 339 13 ( ( -LRB- cord-020235-stcrozdw 339 14 propagated propagate VBN cord-020235-stcrozdw 339 15 in in IN cord-020235-stcrozdw 339 16 Eveline Eveline NNP cord-020235-stcrozdw 339 17 cells cell NNS cord-020235-stcrozdw 339 18 ) ) -RRB- cord-020235-stcrozdw 339 19 by by IN cord-020235-stcrozdw 339 20 solubilization solubilization NNP cord-020235-stcrozdw 339 21 ( ( -LRB- cord-020235-stcrozdw 339 22 freezing freeze VBG cord-020235-stcrozdw 339 23 and and CC cord-020235-stcrozdw 339 24 thawing thawing NN cord-020235-stcrozdw 339 25 ) ) -RRB- cord-020235-stcrozdw 339 26 , , , cord-020235-stcrozdw 339 27 ion ion NN cord-020235-stcrozdw 339 28 exchange exchange NN cord-020235-stcrozdw 339 29 chromatography chromatography NN cord-020235-stcrozdw 339 30 ( ( -LRB- cord-020235-stcrozdw 339 31 phosphocellulose phosphocellulose NNP cord-020235-stcrozdw 339 32 ) ) -RRB- cord-020235-stcrozdw 339 33 and and CC cord-020235-stcrozdw 339 34 preparative preparative JJ cord-020235-stcrozdw 339 35 SDS sds NN cord-020235-stcrozdw 339 36 - - HYPH cord-020235-stcrozdw 339 37 PAGE PAGE NNP cord-020235-stcrozdw 339 38 . . . cord-020235-stcrozdw 340 1 Prior prior RB cord-020235-stcrozdw 340 2 to to IN cord-020235-stcrozdw 340 3 amino amino NN cord-020235-stcrozdw 340 4 acid acid NN cord-020235-stcrozdw 340 5 and and CC cord-020235-stcrozdw 340 6 NH NH NNP cord-020235-stcrozdw 340 7 2-terminal 2-terminal CD cord-020235-stcrozdw 340 8 amino amino NN cord-020235-stcrozdw 340 9 acid acid NN cord-020235-stcrozdw 340 10 sequence sequence NN cord-020235-stcrozdw 340 11 analysis analysis NN cord-020235-stcrozdw 340 12 , , , cord-020235-stcrozdw 340 13 the the DT cord-020235-stcrozdw 340 14 purified purify VBN cord-020235-stcrozdw 340 15 glycoproteins glycoprotein NNS cord-020235-stcrozdw 340 16 were be VBD cord-020235-stcrozdw 340 17 subjected subject VBN cord-020235-stcrozdw 340 18 to to IN cord-020235-stcrozdw 340 19 high high JJ cord-020235-stcrozdw 340 20 performance performance NN cord-020235-stcrozdw 340 21 liquid liquid NN cord-020235-stcrozdw 340 22 chromatography chromatography NN cord-020235-stcrozdw 340 23 ( ( -LRB- cord-020235-stcrozdw 340 24 HPLC HPLC NNP cord-020235-stcrozdw 340 25 ) ) -RRB- cord-020235-stcrozdw 340 26 to to TO cord-020235-stcrozdw 340 27 remove remove VB cord-020235-stcrozdw 340 28 contaminants contaminant NNS cord-020235-stcrozdw 340 29 . . . cord-020235-stcrozdw 341 1 -The -The NNP cord-020235-stcrozdw 341 2 NH NH NNP cord-020235-stcrozdw 341 3 2-terminal 2-terminal CD cord-020235-stcrozdw 341 4 amino amino NN cord-020235-stcrozdw 341 5 acid acid NN cord-020235-stcrozdw 341 6 sequences sequence NNS cord-020235-stcrozdw 341 7 ( ( -LRB- cord-020235-stcrozdw 341 8 23 23 CD cord-020235-stcrozdw 341 9 residues residue NNS cord-020235-stcrozdw 341 10 ) ) -RRB- cord-020235-stcrozdw 341 11 of of IN cord-020235-stcrozdw 341 12 gp71 gp71 NNP cord-020235-stcrozdw 341 13 and and CC cord-020235-stcrozdw 341 14 gp69 gp69 NNPS cord-020235-stcrozdw 341 15 were be VBD cord-020235-stcrozdw 341 16 found find VBN cord-020235-stcrozdw 341 17 to to TO cord-020235-stcrozdw 341 18 be be VB cord-020235-stcrozdw 341 19 different different JJ cord-020235-stcrozdw 341 20 ( ( -LRB- cord-020235-stcrozdw 341 21 in in IN cord-020235-stcrozdw 341 22 10 10 CD cord-020235-stcrozdw 341 23 positions position NNS cord-020235-stcrozdw 341 24 ) ) -RRB- cord-020235-stcrozdw 341 25 but but CC cord-020235-stcrozdw 341 26 highly highly RB cord-020235-stcrozdw 341 27 related related JJ cord-020235-stcrozdw 341 28 . . . cord-020235-stcrozdw 342 1 F F NNP cord-020235-stcrozdw 342 2 - - HYPH cord-020235-stcrozdw 342 3 MuLV MuLV NNP cord-020235-stcrozdw 342 4 gp69 gp69 NNPS cord-020235-stcrozdw 342 5 shows show VBZ cord-020235-stcrozdw 342 6 410f0 410f0 CD cord-020235-stcrozdw 342 7 homology homology NN cord-020235-stcrozdw 342 8 to to IN cord-020235-stcrozdw 342 9 gp71 gp71 NNP cord-020235-stcrozdw 342 10 but but CC cord-020235-stcrozdw 342 11 lacks lack VBZ cord-020235-stcrozdw 342 12 the the DT cord-020235-stcrozdw 342 13 potential potential JJ cord-020235-stcrozdw 342 14 glycosylation glycosylation NN cord-020235-stcrozdw 342 15 site site NN cord-020235-stcrozdw 342 16 ( ( -LRB- cord-020235-stcrozdw 342 17 sequon sequon NNP cord-020235-stcrozdw 342 18 ) ) -RRB- cord-020235-stcrozdw 342 19 at at IN cord-020235-stcrozdw 342 20 position position NN cord-020235-stcrozdw 342 21 12 12 CD cord-020235-stcrozdw 342 22 in in IN cord-020235-stcrozdw 342 23 both both DT cord-020235-stcrozdw 342 24 F F NNP cord-020235-stcrozdw 342 25 - - HYPH cord-020235-stcrozdw 342 26 MuLV MuLV NNP cord-020235-stcrozdw 342 27 gp71 gp71 NNP cord-020235-stcrozdw 342 28 and and CC cord-020235-stcrozdw 342 29 R R NNP cord-020235-stcrozdw 342 30 - - HYPH cord-020235-stcrozdw 342 31 MuLV mulv JJ cord-020235-stcrozdw 342 32 gp70 gp70 NN cord-020235-stcrozdw 342 33 . . . cord-020235-stcrozdw 343 1 et et NNP cord-020235-stcrozdw 343 2 al al NNP cord-020235-stcrozdw 343 3 . . NNP cord-020235-stcrozdw 343 4 , , , cord-020235-stcrozdw 343 5 1980 1980 CD cord-020235-stcrozdw 343 6 ) ) -RRB- cord-020235-stcrozdw 343 7 . . . cord-020235-stcrozdw 344 1 In in IN cord-020235-stcrozdw 344 2 our -PRON- PRP$ cord-020235-stcrozdw 344 3 laborato laborato NN cord-020235-stcrozdw 344 4 ry ry NN cord-020235-stcrozdw 344 5 99 99 CD cord-020235-stcrozdw 344 6 breast breast NN cord-020235-stcrozdw 344 7 can can MD cord-020235-stcrozdw 344 8 cers cers NNP cord-020235-stcrozdw 344 9 , , , cord-020235-stcrozdw 344 10 60 60 CD cord-020235-stcrozdw 344 11 normal normal JJ cord-020235-stcrozdw 344 12 breast breast NN cord-020235-stcrozdw 344 13 tissues tissue NNS cord-020235-stcrozdw 344 14 , , , cord-020235-stcrozdw 344 15 44 44 CD cord-020235-stcrozdw 344 16 benign benign JJ cord-020235-stcrozdw 344 17 breast breast NN cord-020235-stcrozdw 344 18 lesions lesion NNS cord-020235-stcrozdw 344 19 and and CC cord-020235-stcrozdw 344 20 10 10 CD cord-020235-stcrozdw 344 21 other other JJ cord-020235-stcrozdw 344 22 carcin carcin NNS cord-020235-stcrozdw 344 23 om om NN cord-020235-stcrozdw 344 24 as as IN cord-020235-stcrozdw 344 25 from from IN cord-020235-stcrozdw 344 26 south south JJ cord-020235-stcrozdw 344 27 german german JJ cord-020235-stcrozdw 344 28 patients patient NNS cord-020235-stcrozdw 344 29 were be VBD cord-020235-stcrozdw 344 30 tested test VBN cord-020235-stcrozdw 344 31 for for IN cord-020235-stcrozdw 344 32 crossrea crossrea NNP cord-020235-stcrozdw 344 33 ctivit ctivit NNP cord-020235-stcrozdw 345 1 y y NNP cord-020235-stcrozdw 345 2 w w NNP cord-020235-stcrozdw 345 3 ith ith NNP cord-020235-stcrozdw 345 4 MMTV MMTV NNP cord-020235-stcrozdw 345 5 - - HYPH cord-020235-stcrozdw 345 6 gp52 gp52 NNP cord-020235-stcrozdw 345 7 . . . cord-020235-stcrozdw 346 1 The the DT cord-020235-stcrozdw 346 2 tests test NNS cord-020235-stcrozdw 346 3 were be VBD cord-020235-stcrozdw 346 4 done do VBN cord-020235-stcrozdw 346 5 by by IN cord-020235-stcrozdw 346 6 indirect indirect JJ cord-020235-stcrozdw 346 7 immunoperoxidase immunoperoxidase NN cord-020235-stcrozdw 346 8 staining stain VBG cord-020235-stcrozdw 346 9 on on IN cord-020235-stcrozdw 346 10 paraffin paraffin NN cord-020235-stcrozdw 346 11 - - HYPH cord-020235-stcrozdw 346 12 sections section NNS cord-020235-stcrozdw 346 13 using use VBG cord-020235-stcrozdw 346 14 antise antise NN cord-020235-stcrozdw 346 15 ra ra NNP cord-020235-stcrozdw 346 16 against against IN cord-020235-stcrozdw 346 17 gp52 gp52 NNP cord-020235-stcrozdw 346 18 prov prov NNP cord-020235-stcrozdw 346 19 ided ided NNP cord-020235-stcrozdw 346 20 by by IN cord-020235-stcrozdw 346 21 Dr. Dr. NNP cord-020235-stcrozdw 346 22 Spiegelman Spiegelman NNP cord-020235-stcrozdw 346 23 , , , cord-020235-stcrozdw 346 24 N. N. NNP cord-020235-stcrozdw 346 25 Y. Y. NNP cord-020235-stcrozdw 346 26 Specificity Specificity NNP cord-020235-stcrozdw 346 27 of of IN cord-020235-stcrozdw 346 28 positive positive JJ cord-020235-stcrozdw 346 29 reactions reaction NNS cord-020235-stcrozdw 347 1 wa wa NNP cord-020235-stcrozdw 347 2 s s NNP cord-020235-stcrozdw 347 3 controlled control VBN cord-020235-stcrozdw 347 4 by by IN cord-020235-stcrozdw 347 5 preabsorption preabsorption NN cord-020235-stcrozdw 347 6 with with IN cord-020235-stcrozdw 347 7 purified purify VBN cord-020235-stcrozdw 347 8 MMTV MMTV NNP cord-020235-stcrozdw 347 9 - - HYPH cord-020235-stcrozdw 347 10 gp52 gp52 NNP cord-020235-stcrozdw 347 11 . . . cord-020235-stcrozdw 348 1 86 86 CD cord-020235-stcrozdw 348 2 breast breast NN cord-020235-stcrozdw 348 3 cancers cancer NNS cord-020235-stcrozdw 348 4 ( ( -LRB- cord-020235-stcrozdw 348 5 87 87 CD cord-020235-stcrozdw 348 6 0 0 CD cord-020235-stcrozdw 348 7 /0 /0 . cord-020235-stcrozdw 348 8 ) ) -RRB- cord-020235-stcrozdw 348 9 and and CC cord-020235-stcrozdw 348 10 13 13 CD cord-020235-stcrozdw 348 11 benign benign JJ cord-020235-stcrozdw 348 12 breast breast NN cord-020235-stcrozdw 348 13 lesions lesion NNS cord-020235-stcrozdw 348 14 ( ( -LRB- cord-020235-stcrozdw 348 15 30 30 CD cord-020235-stcrozdw 348 16 0 0 CD cord-020235-stcrozdw 348 17 /0 /0 . cord-020235-stcrozdw 348 18 ) ) -RRB- cord-020235-stcrozdw 348 19 gave give VBD cord-020235-stcrozdw 348 20 positive positive JJ cord-020235-stcrozdw 348 21 reactions reaction NNS cord-020235-stcrozdw 348 22 , , , cord-020235-stcrozdw 348 23 whereas whereas IN cord-020235-stcrozdw 348 24 normal normal JJ cord-020235-stcrozdw 348 25 bre bre NNP cord-020235-stcrozdw 348 26 ast ast NN cord-020235-stcrozdw 348 27 tissue tissue NN cord-020235-stcrozdw 348 28 and and CC cord-020235-stcrozdw 348 29 other other JJ cord-020235-stcrozdw 348 30 carcinomas carcinoma NNS cord-020235-stcrozdw 348 31 were be VBD cord-020235-stcrozdw 348 32 negative negative JJ cord-020235-stcrozdw 348 33 . . . cord-020235-stcrozdw 349 1 -The -the DT cord-020235-stcrozdw 349 2 test test NN cord-020235-stcrozdw 349 3 might may MD cord-020235-stcrozdw 349 4 be be VB cord-020235-stcrozdw 349 5 an an DT cord-020235-stcrozdw 349 6 additional additional JJ cord-020235-stcrozdw 349 7 useful useful JJ cord-020235-stcrozdw 349 8 diagnostic diagnostic NN cord-020235-stcrozdw 349 9 too too RB cord-020235-stcrozdw 349 10 l l NN cord-020235-stcrozdw 349 11 for for IN cord-020235-stcrozdw 349 12 the the DT cord-020235-stcrozdw 349 13 earl earl NNP cord-020235-stcrozdw 349 14 y y NNP cord-020235-stcrozdw 349 15 detection detection NN cord-020235-stcrozdw 349 16 of of IN cord-020235-stcrozdw 349 17 micrometastases micrometastase NNS cord-020235-stcrozdw 349 18 , , , cord-020235-stcrozdw 349 19 for for IN cord-020235-stcrozdw 349 20 the the DT cord-020235-stcrozdw 349 21 assignment assignment NN cord-020235-stcrozdw 349 22 of of IN cord-020235-stcrozdw 349 23 metastases metastasis NNS cord-020235-stcrozdw 349 24 from from IN cord-020235-stcrozdw 349 25 unknown unknown JJ cord-020235-stcrozdw 349 26 pr pr FW cord-020235-stcrozdw 349 27 imary imary JJ cord-020235-stcrozdw 349 28 tumors tumor NNS cord-020235-stcrozdw 349 29 and and CC cord-020235-stcrozdw 349 30 in in IN cord-020235-stcrozdw 349 31 doubtful doubtful JJ cord-020235-stcrozdw 349 32 cases case NNS cord-020235-stcrozdw 349 33 of of IN cord-020235-stcrozdw 349 34 breast breast NN cord-020235-stcrozdw 349 35 cancer cancer NN cord-020235-stcrozdw 349 36 . . . cord-020235-stcrozdw 350 1 It -PRON- PRP cord-020235-stcrozdw 350 2 can can MD cord-020235-stcrozdw 350 3 possibly possibly RB cord-020235-stcrozdw 350 4 serve serve VB cord-020235-stcrozdw 350 5 as as IN cord-020235-stcrozdw 350 6 an an DT cord-020235-stcrozdw 350 7 add add NN cord-020235-stcrozdw 350 8 itional itional JJ cord-020235-stcrozdw 350 9 criterion criterion NN cord-020235-stcrozdw 350 10 for for IN cord-020235-stcrozdw 350 11 the the DT cord-020235-stcrozdw 350 12 classification classification NN cord-020235-stcrozdw 350 13 of of IN cord-020235-stcrozdw 350 14 mastopath mastopath NNP cord-020235-stcrozdw 350 15 ies ies NNP cord-020235-stcrozdw 350 16 . . . cord-020235-stcrozdw 351 1 Viruses virus NNS cord-020235-stcrozdw 351 2 wer wer VBP cord-020235-stcrozdw 351 3 e e XX cord-020235-stcrozdw 351 4 found find VBN cord-020235-stcrozdw 351 5 in in IN cord-020235-stcrozdw 351 6 3,691 3,691 CD cord-020235-stcrozdw 351 7 patients patient NNS cord-020235-stcrozdw 351 8 . . . cord-020235-stcrozdw 352 1 Nearly nearly RB cord-020235-stcrozdw 352 2 all all DT cord-020235-stcrozdw 352 3 illnesses illness NNS cord-020235-stcrozdw 352 4 were be VBD cord-020235-stcrozdw 352 5 caused cause VBN cord-020235-stcrozdw 352 6 by by IN cord-020235-stcrozdw 352 7 mumps mumps NN cord-020235-stcrozdw 352 8 - - : cord-020235-stcrozdw 352 9 and and CC cord-020235-stcrozdw 352 10 entero entero NNP cord-020235-stcrozdw 352 11 - - HYPH cord-020235-stcrozdw 352 12 viruses virus NNS cord-020235-stcrozdw 352 13 , , , cord-020235-stcrozdw 352 14 Other other JJ cord-020235-stcrozdw 352 15 viru viru NNP cord-020235-stcrozdw 352 16 ses ses NNP cord-020235-stcrozdw 352 17 were be VBD cord-020235-stcrozdw 352 18 found find VBN cord-020235-stcrozdw 352 19 in in IN cord-020235-stcrozdw 352 20 less less JJR cord-020235-stcrozdw 352 21 than than IN cord-020235-stcrozdw 352 22 5 5 CD cord-020235-stcrozdw 352 23 % % NN cord-020235-stcrozdw 352 24 of of IN cord-020235-stcrozdw 352 25 all all DT cord-020235-stcrozdw 352 26 cases case NNS cord-020235-stcrozdw 352 27 . . . cord-020235-stcrozdw 353 1 The the DT cord-020235-stcrozdw 353 2 mumpsmeningitides mumpsmeningitide NNS cord-020235-stcrozdw 353 3 were be VBD cord-020235-stcrozdw 353 4 ascertained ascertain VBN cord-020235-stcrozdw 353 5 constantly constantly RB cord-020235-stcrozdw 353 6 over over IN cord-020235-stcrozdw 353 7 all all PDT cord-020235-stcrozdw 353 8 these these DT cord-020235-stcrozdw 353 9 year year NN cord-020235-stcrozdw 354 1 s. s. NNP cord-020235-stcrozdw 355 1 In in IN cord-020235-stcrozdw 355 2 1967 1967 CD cord-020235-stcrozdw 356 1 In in IN cord-020235-stcrozdw 356 2 , , , cord-020235-stcrozdw 356 3 1974 1974 CD cord-020235-stcrozdw 357 1 In in IN cord-020235-stcrozdw 357 2 and and CC cord-020235-stcrozdw 357 3 1980 1980 CD cord-020235-stcrozdw 357 4 an an DT cord-020235-stcrozdw 357 5 increased increase VBN cord-020235-stcrozdw 357 6 incide incide NN cord-020235-stcrozdw 357 7 nce nce NNP cord-020235-stcrozdw 357 8 of of IN cord-020235-stcrozdw 357 9 meningitides meningitide NNS cord-020235-stcrozdw 357 10 caused cause VBN cord-020235-stcrozdw 357 11 by by IN cord-020235-stcrozdw 357 12 Echo echo NN cord-020235-stcrozdw 357 13 - - HYPH cord-020235-stcrozdw 357 14 virus virus NN cord-020235-stcrozdw 357 15 type type NN cord-020235-stcrozdw 357 16 30 30 CD cord-020235-stcrozdw 357 17 wa wa NNP cord-020235-stcrozdw 357 18 s s NNP cord-020235-stcrozdw 357 19 seen see VBN cord-020235-stcrozdw 357 20 . . . cord-020235-stcrozdw 358 1 -There -There NNP cord-020235-stcrozdw 358 2 was be VBD cord-020235-stcrozdw 358 3 no no DT cord-020235-stcrozdw 358 4 seaso seaso NN cord-020235-stcrozdw 358 5 na na NNP cord-020235-stcrozdw 358 6 l l NNP cord-020235-stcrozdw 358 7 dep dep NNP cord-020235-stcrozdw 358 8 endence endence NN cord-020235-stcrozdw 358 9 on on IN cord-020235-stcrozdw 358 10 the the DT cord-020235-stcrozdw 358 11 occurrence occurrence NN cord-020235-stcrozdw 358 12 of of IN cord-020235-stcrozdw 358 13 mumps mumps NN cord-020235-stcrozdw 358 14 virus virus NN cord-020235-stcrozdw 358 15 meningitides meningitide NNS cord-020235-stcrozdw 358 16 . . . cord-020235-stcrozdw 359 1 Meningitides Meningitides NNP cord-020235-stcrozdw 359 2 , , , cord-020235-stcrozdw 359 3 caused cause VBN cord-020235-stcrozdw 359 4 by by IN cord-020235-stcrozdw 359 5 ent ent NNP cord-020235-stcrozdw 359 6 ero ero NNP cord-020235-stcrozdw 359 7 - - HYPH cord-020235-stcrozdw 359 8 viruses virus NNS cord-020235-stcrozdw 359 9 was be VBD cord-020235-stcrozdw 359 10 found find VBN cord-020235-stcrozdw 359 11 mor mor CC cord-020235-stcrozdw 359 12 e e XX cord-020235-stcrozdw 359 13 often often RB cord-020235-stcrozdw 359 14 in in IN cord-020235-stcrozdw 359 15 the the DT cord-020235-stcrozdw 359 16 autumn autumn NN cord-020235-stcrozdw 359 17 . . . cord-020235-stcrozdw 360 1 Male male JJ cord-020235-stcrozdw 360 2 patients patient NNS cord-020235-stcrozdw 360 3 fell fall VBD cord-020235-stcrozdw 360 4 ill ill RB cord-020235-stcrozdw 360 5 twice twice RB cord-020235-stcrozdw 360 6 as as IN cord-020235-stcrozdw 360 7 ofte ofte NNP cord-020235-stcrozdw 360 8 n n NNP cord-020235-stcrozdw 360 9 as as IN cord-020235-stcrozdw 360 10 female female JJ cord-020235-stcrozdw 360 11 patients patient NNS cord-020235-stcrozdw 360 12 . . . cord-020235-stcrozdw 361 1 Mumps mumps NN cord-020235-stcrozdw 361 2 - - HYPH cord-020235-stcrozdw 361 3 meningitides meningitide NNS cord-020235-stcrozdw 361 4 were be VBD cord-020235-stcrozdw 361 5 rarel rarel NNP cord-020235-stcrozdw 361 6 y y NNP cord-020235-stcrozdw 361 7 found find VBD cord-020235-stcrozdw 361 8 in in IN cord-020235-stcrozdw 361 9 the the DT cord-020235-stcrozdw 361 10 first first JJ cord-020235-stcrozdw 361 11 year year NN cord-020235-stcrozdw 361 12 of of IN cord-020235-stcrozdw 361 13 life life NN cord-020235-stcrozdw 361 14 . . . cord-020235-stcrozdw 362 1 In in IN cord-020235-stcrozdw 362 2 contras contras NNP cord-020235-stcrozdw 362 3 t t NNP cord-020235-stcrozdw 362 4 , , , cord-020235-stcrozdw 362 5 enterovirus enterovirus NN cord-020235-stcrozdw 362 6 meningitides meningitide NNS cord-020235-stcrozdw 362 7 could could MD cord-020235-stcrozdw 362 8 be be VB cord-020235-stcrozdw 362 9 dete dete NNP cord-020235-stcrozdw 362 10 cted cte VBN cord-020235-stcrozdw 362 11 during during IN cord-020235-stcrozdw 362 12 the the DT cord-020235-stcrozdw 362 13 first first JJ cord-020235-stcrozdw 362 14 year year NN cord-020235-stcrozdw 362 15 and and CC cord-020235-stcrozdw 362 16 caused cause VBD cord-020235-stcrozdw 362 17 men man NNS cord-020235-stcrozdw 362 18 ingitides ingitide NNS cord-020235-stcrozdw 362 19 to to IN cord-020235-stcrozdw 362 20 age age NN cord-020235-stcrozdw 362 21 of of IN cord-020235-stcrozdw 362 22 14 14 CD cord-020235-stcrozdw 362 23 . . . cord-020235-stcrozdw 363 1 Virus virus NN cord-020235-stcrozdw 363 2 meningitides meningitide NNS cord-020235-stcrozdw 363 3 among among IN cord-020235-stcrozdw 363 4 adults adult NNS cord-020235-stcrozdw 363 5 were be VBD cord-020235-stcrozdw 363 6 rarel rarel NNP cord-020235-stcrozdw 363 7 y y NNP cord-020235-stcrozdw 363 8 found find VBD cord-020235-stcrozdw 363 9 . . . cord-020235-stcrozdw 364 1 We -PRON- PRP cord-020235-stcrozdw 364 2 suspected suspect VBD cord-020235-stcrozdw 364 3 that that IN cord-020235-stcrozdw 364 4 a a DT cord-020235-stcrozdw 364 5 number number NN cord-020235-stcrozdw 364 6 of of IN cord-020235-stcrozdw 364 7 peripheral peripheral JJ cord-020235-stcrozdw 364 8 facial facial JJ cord-020235-stcrozdw 364 9 pareses parese NNS cord-020235-stcrozdw 364 10 ( ( -LRB- cord-020235-stcrozdw 364 11 P.F.P. P.F.P. NNP cord-020235-stcrozdw 364 12 ) ) -RRB- cord-020235-stcrozdw 364 13 considered consider VBD cord-020235-stcrozdw 364 14 " " `` cord-020235-stcrozdw 364 15 idiopathic idiopathic JJ cord-020235-stcrozdw 364 16 " " '' cord-020235-stcrozdw 364 17 might may MD cord-020235-stcrozdw 364 18 , , , cord-020235-stcrozdw 364 19 in in IN cord-020235-stcrozdw 364 20 fact fact NN cord-020235-stcrozdw 364 21 , , , cord-020235-stcrozdw 364 22 have have VB cord-020235-stcrozdw 364 23 a a DT cord-020235-stcrozdw 364 24 viral viral JJ cord-020235-stcrozdw 364 25 aetiology aetiology NN cord-020235-stcrozdw 364 26 . . . cord-020235-stcrozdw 365 1 71 71 CD cord-020235-stcrozdw 365 2 patients patient NNS cord-020235-stcrozdw 365 3 of of IN cord-020235-stcrozdw 365 4 the the DT cord-020235-stcrozdw 365 5 Cologne Cologne NNP cord-020235-stcrozdw 365 6 University University NNP cord-020235-stcrozdw 365 7 E.N.T. E.N.T. NNP cord-020235-stcrozdw 365 8 Clinic Clinic NNP cord-020235-stcrozdw 365 9 with with IN cord-020235-stcrozdw 365 10 so so RB cord-020235-stcrozdw 365 11 - - HYPH cord-020235-stcrozdw 365 12 called call VBN cord-020235-stcrozdw 365 13 idiopathic idiopathic JJ cord-020235-stcrozdw 365 14 P.F.P. P.F.P. NNP cord-020235-stcrozdw 365 15 were be VBD cord-020235-stcrozdw 365 16 examined examine VBN cord-020235-stcrozdw 365 17 under under IN cord-020235-stcrozdw 365 18 the the DT cord-020235-stcrozdw 365 19 aspect aspect NN cord-020235-stcrozdw 365 20 of of IN cord-020235-stcrozdw 365 21 a a DT cord-020235-stcrozdw 365 22 viral viral JJ cord-020235-stcrozdw 365 23 aetiology aetiology NN cord-020235-stcrozdw 365 24 . . . cord-020235-stcrozdw 366 1 In in IN cord-020235-stcrozdw 366 2 32 32 CD cord-020235-stcrozdw 366 3 cases case NNS cord-020235-stcrozdw 366 4 conditions condition NNS cord-020235-stcrozdw 366 5 for for IN cord-020235-stcrozdw 366 6 virological virological JJ cord-020235-stcrozdw 366 7 investigations investigation NNS cord-020235-stcrozdw 366 8 were be VBD cord-020235-stcrozdw 366 9 optimal optimal JJ cord-020235-stcrozdw 366 10 ( ( -LRB- cord-020235-stcrozdw 366 11 paired pair VBN cord-020235-stcrozdw 366 12 sera sera NNP cord-020235-stcrozdw 366 13 , , , cord-020235-stcrozdw 366 14 first first JJ cord-020235-stcrozdw 366 15 serum serum NN cord-020235-stcrozdw 366 16 within within IN cord-020235-stcrozdw 366 17 the the DT cord-020235-stcrozdw 366 18 first first JJ cord-020235-stcrozdw 366 19 week week NN cord-020235-stcrozdw 366 20 after after IN cord-020235-stcrozdw 366 21 onset onset NN cord-020235-stcrozdw 366 22 of of IN cord-020235-stcrozdw 366 23 disease disease NN cord-020235-stcrozdw 366 24 ) ) -RRB- cord-020235-stcrozdw 366 25 . . . cord-020235-stcrozdw 367 1 In in IN cord-020235-stcrozdw 367 2 10 10 CD cord-020235-stcrozdw 367 3 of of IN cord-020235-stcrozdw 367 4 these these DT cord-020235-stcrozdw 367 5 32 32 CD cord-020235-stcrozdw 367 6 cases case NNS cord-020235-stcrozdw 367 7 a a DT cord-020235-stcrozdw 367 8 viral viral JJ cord-020235-stcrozdw 367 9 infection infection NN cord-020235-stcrozdw 367 10 could could MD cord-020235-stcrozdw 367 11 be be VB cord-020235-stcrozdw 367 12 proven prove VBN cord-020235-stcrozdw 367 13 ( ( -LRB- cord-020235-stcrozdw 367 14 varicella varicella NN cord-020235-stcrozdw 367 15 zoster zoster NNP cord-020235-stcrozdw 367 16 virus virus NN cord-020235-stcrozdw 367 17 : : : cord-020235-stcrozdw 367 18 7 7 CD cord-020235-stcrozdw 367 19 , , , cord-020235-stcrozdw 367 20 herpes herpes NN cord-020235-stcrozdw 367 21 simplex simplex NNP cord-020235-stcrozdw 367 22 virus virus NN cord-020235-stcrozdw 367 23 : : : cord-020235-stcrozdw 367 24 2 2 CD cord-020235-stcrozdw 367 25 , , , cord-020235-stcrozdw 367 26 coxsackie coxsackie NNP cord-020235-stcrozdw 367 27 B B NNP cord-020235-stcrozdw 367 28 4 4 CD cord-020235-stcrozdw 367 29 : : SYM cord-020235-stcrozdw 367 30 1 1 CD cord-020235-stcrozdw 367 31 ) ) -RRB- cord-020235-stcrozdw 367 32 . . . cord-020235-stcrozdw 368 1 In in IN cord-020235-stcrozdw 368 2 5 5 CD cord-020235-stcrozdw 368 3 of of IN cord-020235-stcrozdw 368 4 7 7 CD cord-020235-stcrozdw 368 5 VZV VZV NNP cord-020235-stcrozdw 368 6 cases case NNS cord-020235-stcrozdw 368 7 minimal minimal JJ cord-020235-stcrozdw 368 8 zoster zoster NN cord-020235-stcrozdw 368 9 lesions lesion NNS cord-020235-stcrozdw 368 10 were be VBD cord-020235-stcrozdw 368 11 observed observe VBN cord-020235-stcrozdw 368 12 , , , cord-020235-stcrozdw 368 13 4 4 CD cord-020235-stcrozdw 368 14 facial facial NN cord-020235-stcrozdw 368 15 and and CC cord-020235-stcrozdw 368 16 1 1 CD cord-020235-stcrozdw 368 17 thoracic thoracic NN cord-020235-stcrozdw 368 18 . . . cord-020235-stcrozdw 369 1 Among among IN cord-020235-stcrozdw 369 2 the the DT cord-020235-stcrozdw 369 3 39 39 CD cord-020235-stcrozdw 369 4 oth oth NNS cord-020235-stcrozdw 369 5 er er UH cord-020235-stcrozdw 369 6 patients patient NNS cord-020235-stcrozdw 369 7 ( ( -LRB- cord-020235-stcrozdw 369 8 with with IN cord-020235-stcrozdw 369 9 late late JJ cord-020235-stcrozdw 369 10 sera sera NNP cord-020235-stcrozdw 369 11 ) ) -RRB- cord-020235-stcrozdw 369 12 no no DT cord-020235-stcrozdw 369 13 viral viral JJ cord-020235-stcrozdw 369 14 infection infection NN cord-020235-stcrozdw 369 15 could could MD cord-020235-stcrozdw 369 16 be be VB cord-020235-stcrozdw 369 17 proven prove VBN cord-020235-stcrozdw 369 18 . . . cord-020235-stcrozdw 370 1 In in IN cord-020235-stcrozdw 370 2 conclusion conclusion NN cord-020235-stcrozdw 370 3 , , , cord-020235-stcrozdw 370 4 by by IN cord-020235-stcrozdw 370 5 means mean NNS cord-020235-stcrozdw 370 6 of of IN cord-020235-stcrozdw 370 7 alert alert JJ cord-020235-stcrozdw 370 8 clinical clinical JJ cord-020235-stcrozdw 370 9 and and CC cord-020235-stcrozdw 370 10 virological virological JJ cord-020235-stcrozdw 370 11 examinat examinat NNP cord-020235-stcrozdw 370 12 ions ion NNS cord-020235-stcrozdw 370 13 , , , cord-020235-stcrozdw 370 14 a a DT cord-020235-stcrozdw 370 15 considerable considerable JJ cord-020235-stcrozdw 370 16 fract fract NN cord-020235-stcrozdw 370 17 ion ion NN cord-020235-stcrozdw 370 18 of of IN cord-020235-stcrozdw 370 19 idiopathic idiopathic JJ cord-020235-stcrozdw 370 20 P.F.P. P.F.P. NNP cord-020235-stcrozdw 370 21 could could MD cord-020235-stcrozdw 370 22 be be VB cord-020235-stcrozdw 370 23 associated associate VBN cord-020235-stcrozdw 370 24 with with IN cord-020235-stcrozdw 370 25 a a DT cord-020235-stcrozdw 370 26 virus virus NN cord-020235-stcrozdw 370 27 infection infection NN cord-020235-stcrozdw 370 28 . . . cord-020235-stcrozdw 371 1 152 152 CD cord-020235-stcrozdw 371 2 neonates neonate NNS cord-020235-stcrozdw 371 3 were be VBD cord-020235-stcrozdw 371 4 screened screen VBN cord-020235-stcrozdw 371 5 from from IN cord-020235-stcrozdw 371 6 the the DT cord-020235-stcrozdw 371 7 delivery delivery NN cord-020235-stcrozdw 371 8 to to IN cord-020235-stcrozdw 371 9 the the DT cord-020235-stcrozdw 371 10 time time NN cord-020235-stcrozdw 371 11 of of IN cord-020235-stcrozdw 371 12 discharge discharge NN cord-020235-stcrozdw 371 13 for for IN cord-020235-stcrozdw 371 14 rotavirus rotavirus JJ cord-020235-stcrozdw 371 15 infections infection NNS cord-020235-stcrozdw 371 16 . . . cord-020235-stcrozdw 372 1 Daily daily JJ cord-020235-stcrozdw 372 2 faecal faecal JJ cord-020235-stcrozdw 372 3 specimens specimen NNS cord-020235-stcrozdw 372 4 were be VBD cord-020235-stcrozdw 372 5 examined examine VBN cord-020235-stcrozdw 372 6 by by IN cord-020235-stcrozdw 372 7 an an DT cord-020235-stcrozdw 372 8 enzyme enzyme NN cord-020235-stcrozdw 372 9 - - HYPH cord-020235-stcrozdw 372 10 linked link VBN cord-020235-stcrozdw 372 11 immunosorbent immunosorbent JJ cord-020235-stcrozdw 372 12 assay assay NN cord-020235-stcrozdw 372 13 ( ( -LRB- cord-020235-stcrozdw 372 14 ELISA ELISA NNP cord-020235-stcrozdw 372 15 ) ) -RRB- cord-020235-stcrozdw 372 16 and and CC cord-020235-stcrozdw 372 17 a a DT cord-020235-stcrozdw 372 18 subgroup subgroup NN cord-020235-stcrozdw 372 19 of of IN cord-020235-stcrozdw 372 20 positive positive JJ cord-020235-stcrozdw 372 21 specimens specimen NNS cord-020235-stcrozdw 372 22 were be VBD cord-020235-stcrozdw 372 23 also also RB cord-020235-stcrozdw 372 24 tested test VBN cord-020235-stcrozdw 372 25 by by IN cord-020235-stcrozdw 372 26 a a DT cord-020235-stcrozdw 372 27 negative negative JJ cord-020235-stcrozdw 372 28 staining stain VBG cord-020235-stcrozdw 372 29 electromicro electromicro NNP cord-020235-stcrozdw 372 30 scopic scopic NNP cord-020235-stcrozdw 372 31 method method NN cord-020235-stcrozdw 372 32 . . . cord-020235-stcrozdw 373 1 -22 -22 IN cord-020235-stcrozdw 373 2 babies baby NNS cord-020235-stcrozdw 373 3 ( ( -LRB- cord-020235-stcrozdw 373 4 14.5 14.5 CD cord-020235-stcrozdw 373 5 0/0 0/0 NFP cord-020235-stcrozdw 373 6 ) ) -RRB- cord-020235-stcrozdw 373 7 were be VBD cord-020235-stcrozdw 373 8 found find VBN cord-020235-stcrozdw 373 9 to to TO cord-020235-stcrozdw 373 10 excrete excrete VB cord-020235-stcrozdw 373 11 rotavirus rotavirus NN cord-020235-stcrozdw 373 12 . . . cord-020235-stcrozdw 374 1 20 20 CD cord-020235-stcrozdw 374 2 of of IN cord-020235-stcrozdw 374 3 them -PRON- PRP cord-020235-stcrozdw 374 4 were be VBD cord-020235-stcrozdw 374 5 asymptomatic asymptomatic JJ cord-020235-stcrozdw 374 6 infected infect VBN cord-020235-stcrozdw 374 7 and and CC cord-020235-stcrozdw 374 8 2 2 CD cord-020235-stcrozdw 374 9 showed show VBD cord-020235-stcrozdw 374 10 mild mild JJ cord-020235-stcrozdw 374 11 gastrointestinal gastrointestinal JJ cord-020235-stcrozdw 374 12 symptoms symptom NNS cord-020235-stcrozdw 374 13 . . . cord-020235-stcrozdw 375 1 With with IN cord-020235-stcrozdw 375 2 one one CD cord-020235-stcrozdw 375 3 exception exception NN cord-020235-stcrozdw 375 4 viruses virus NNS cord-020235-stcrozdw 375 5 were be VBD cord-020235-stcrozdw 375 6 not not RB cord-020235-stcrozdw 375 7 detected detect VBN cord-020235-stcrozdw 375 8 in in IN cord-020235-stcrozdw 375 9 babies baby NNS cord-020235-stcrozdw 376 1 less less JJR cord-020235-stcrozdw 376 2 than than IN cord-020235-stcrozdw 376 3 24 24 CD cord-020235-stcrozdw 376 4 h h NN cord-020235-stcrozdw 376 5 old old JJ cord-020235-stcrozdw 376 6 , , , cord-020235-stcrozdw 376 7 but but CC cord-020235-stcrozdw 376 8 10.9 10.9 CD cord-020235-stcrozdw 376 9 % % NN cord-020235-stcrozdw 376 10 of of IN cord-020235-stcrozdw 376 11 them -PRON- PRP cord-020235-stcrozdw 376 12 excreted excrete VBD cord-020235-stcrozdw 376 13 virus virus NN cord-020235-stcrozdw 376 14 during during IN cord-020235-stcrozdw 376 15 the the DT cord-020235-stcrozdw 376 16 second second JJ cord-020235-stcrozdw 376 17 day day NN cord-020235-stcrozdw 376 18 of of IN cord-020235-stcrozdw 376 19 life life NN cord-020235-stcrozdw 376 20 and and CC cord-020235-stcrozdw 376 21 after after IN cord-020235-stcrozdw 376 22 10 10 CD cord-020235-stcrozdw 376 23 days day NNS cord-020235-stcrozdw 376 24 30 30 CD cord-020235-stcrozdw 376 25 % % NN cord-020235-stcrozdw 376 26 of of IN cord-020235-stcrozdw 376 27 the the DT cord-020235-stcrozdw 376 28 neonates neonate NNS cord-020235-stcrozdw 376 29 were be VBD cord-020235-stcrozdw 376 30 positive positive JJ cord-020235-stcrozdw 376 31 for for IN cord-020235-stcrozdw 376 32 rotavirus rotavirus NN cord-020235-stcrozdw 376 33 . . . cord-020235-stcrozdw 377 1 -Excretion -Excretion NNP cord-020235-stcrozdw 377 2 persisted persist VBD cord-020235-stcrozdw 377 3 for for IN cord-020235-stcrozdw 377 4 1 1 CD cord-020235-stcrozdw 377 5 to to TO cord-020235-stcrozdw 377 6 5 5 CD cord-020235-stcrozdw 377 7 days day NNS cord-020235-stcrozdw 377 8 . . . cord-020235-stcrozdw 378 1 According accord VBG cord-020235-stcrozdw 378 2 to to IN cord-020235-stcrozdw 378 3 our -PRON- PRP$ cord-020235-stcrozdw 378 4 study study NN cord-020235-stcrozdw 378 5 most most JJS cord-020235-stcrozdw 378 6 babies baby NNS cord-020235-stcrozdw 378 7 ( ( -LRB- cord-020235-stcrozdw 378 8 40 40 CD cord-020235-stcrozdw 378 9 0 0 CD cord-020235-stcrozdw 378 10 /0 /0 . cord-020235-stcrozdw 378 11 ) ) -RRB- cord-020235-stcrozdw 378 12 excreted excrete VBD cord-020235-stcrozdw 378 13 roravirus roravirus NN cord-020235-stcrozdw 378 14 for for IN cord-020235-stcrozdw 378 15 3 3 CD cord-020235-stcrozdw 378 16 days day NNS cord-020235-stcrozdw 378 17 . . . cord-020235-stcrozdw 379 1 -A -A . cord-020235-stcrozdw 380 1 great great JJ cord-020235-stcrozdw 380 2 number number NN cord-020235-stcrozdw 380 3 of of IN cord-020235-stcrozdw 380 4 the the DT cord-020235-stcrozdw 380 5 stools stool NNS cord-020235-stcrozdw 380 6 ( ( -LRB- cord-020235-stcrozdw 380 7 29 29 CD cord-020235-stcrozdw 380 8 % % NN cord-020235-stcrozdw 380 9 ) ) -RRB- cord-020235-stcrozdw 380 10 from from IN cord-020235-stcrozdw 380 11 the the DT cord-020235-stcrozdw 380 12 first first JJ cord-020235-stcrozdw 380 13 da da NNP cord-020235-stcrozdw 380 14 y y NNP cord-020235-stcrozdw 380 15 which which WDT cord-020235-stcrozdw 380 16 were be VBD cord-020235-stcrozdw 380 17 tested test VBN cord-020235-stcrozdw 380 18 by by IN cord-020235-stcrozdw 380 19 ELISA ELISA NNP cord-020235-stcrozdw 380 20 were be VBD cord-020235-stcrozdw 380 21 found find VBN cord-020235-stcrozdw 380 22 to to TO cord-020235-stcrozdw 380 23 have have VB cord-020235-stcrozdw 380 24 nonspecific nonspecific JJ cord-020235-stcrozdw 380 25 activity activity NN cord-020235-stcrozdw 380 26 in in IN cord-020235-stcrozdw 380 27 the the DT cord-020235-stcrozdw 380 28 absence absence NN cord-020235-stcrozdw 380 29 of of IN cord-020235-stcrozdw 380 30 rotaviral rotaviral JJ cord-020235-stcrozdw 380 31 antigen antigen NN cord-020235-stcrozdw 380 32 . . . cord-020235-stcrozdw 381 1 Theref Theref NNP cord-020235-stcrozdw 381 2 ore ore NN cord-020235-stcrozdw 381 3 such such JJ cord-020235-stcrozdw 381 4 stool stool NN cord-020235-stcrozdw 381 5 specimens specimen NNS cord-020235-stcrozdw 381 6 should should MD cord-020235-stcrozdw 381 7 only only RB cord-020235-stcrozdw 381 8 be be VB cord-020235-stcrozdw 381 9 examined examine VBN cord-020235-stcrozdw 381 10 by by IN cord-020235-stcrozdw 381 11 electron electron NN cord-020235-stcrozdw 381 12 microscopy microscopy NN cord-020235-stcrozdw 381 13 . . . cord-020235-stcrozdw 382 1 The the DT cord-020235-stcrozdw 382 2 single single JJ cord-020235-stcrozdw 382 3 radial radial JJ cord-020235-stcrozdw 382 4 hemolysis hemolysis NN cord-020235-stcrozdw 382 5 test test NN cord-020235-stcrozdw 382 6 ( ( -LRB- cord-020235-stcrozdw 382 7 SRH SRH NNP cord-020235-stcrozdw 382 8 - - HYPH cord-020235-stcrozdw 382 9 test test NN cord-020235-stcrozdw 382 10 = = SYM cord-020235-stcrozdw 382 11 hemolysis hemolysis NN cord-020235-stcrozdw 382 12 - - HYPH cord-020235-stcrozdw 382 13 in in IN cord-020235-stcrozdw 382 14 - - HYPH cord-020235-stcrozdw 382 15 gel gel NN cord-020235-stcrozdw 382 16 test test NN cord-020235-stcrozdw 382 17 ) ) -RRB- cord-020235-stcrozdw 382 18 is be VBZ cord-020235-stcrozdw 382 19 a a DT cord-020235-stcrozdw 382 20 suitable suitable JJ cord-020235-stcrozdw 382 21 technique technique NN cord-020235-stcrozdw 382 22 for for IN cord-020235-stcrozdw 382 23 detection detection NN cord-020235-stcrozdw 382 24 of of IN cord-020235-stcrozdw 382 25 rubella rubella NN cord-020235-stcrozdw 382 26 and and CC cord-020235-stcrozdw 382 27 influenza influenza NN cord-020235-stcrozdw 382 28 antibodies antibody NNS cord-020235-stcrozdw 382 29 in in IN cord-020235-stcrozdw 382 30 a a DT cord-020235-stcrozdw 382 31 large large JJ cord-020235-stcrozdw 382 32 number number NN cord-020235-stcrozdw 382 33 of of IN cord-020235-stcrozdw 382 34 sera sera NNP cord-020235-stcrozdw 382 35 . . . cord-020235-stcrozdw 383 1 In in IN cord-020235-stcrozdw 383 2 our -PRON- PRP$ cord-020235-stcrozdw 383 3 stud stud NN cord-020235-stcrozdw 383 4 y y NN cord-020235-stcrozdw 383 5 we -PRON- PRP cord-020235-stcrozdw 383 6 looked look VBD cord-020235-stcrozdw 383 7 for for IN cord-020235-stcrozdw 383 8 the the DT cord-020235-stcrozdw 383 9 effect effect NN cord-020235-stcrozdw 383 10 of of IN cord-020235-stcrozdw 383 11 att att NNP cord-020235-stcrozdw 383 12 achment achment NNP cord-020235-stcrozdw 383 13 of of IN cord-020235-stcrozdw 383 14 the the DT cord-020235-stcrozdw 383 15 viral viral JJ cord-020235-stcrozdw 383 16 antigens antigen NNS cord-020235-stcrozdw 383 17 to to IN cord-020235-stcrozdw 383 18 the the DT cord-020235-stcrozdw 383 19 erythrocytes erythrocyte NNS cord-020235-stcrozdw 383 20 by by IN cord-020235-stcrozdw 383 21 different different JJ cord-020235-stcrozdw 383 22 coupling coupling NN cord-020235-stcrozdw 383 23 reagent reagent NN cord-020235-stcrozdw 383 24 s. s. NNP cord-020235-stcrozdw 383 25 Chrom Chrom NNP cord-020235-stcrozdw 383 26 ic ic NN cord-020235-stcrozdw 383 27 chloride chloride NN cord-020235-stcrozdw 383 28 , , , cord-020235-stcrozdw 383 29 cyanogen cyanogen NN cord-020235-stcrozdw 383 30 chloride chloride NN cord-020235-stcrozdw 383 31 , , , cord-020235-stcrozdw 383 32 glutaraldehyd glutaraldehyd NNP cord-020235-stcrozdw 383 33 and and CC cord-020235-stcrozdw 383 34 tetraazotized tetraazotize VBD cord-020235-stcrozdw 383 35 -0 -0 NNP cord-020235-stcrozdw 383 36 -dianisid -dianisid HYPH cord-020235-stcrozdw 383 37 ine ine NNP cord-020235-stcrozdw 383 38 ( ( -LRB- cord-020235-stcrozdw 383 39 TOD TOD NNP cord-020235-stcrozdw 383 40 ) ) -RRB- cord-020235-stcrozdw 383 41 were be VBD cord-020235-stcrozdw 383 42 used use VBN cord-020235-stcrozdw 383 43 for for IN cord-020235-stcrozdw 383 44 the the DT cord-020235-stcrozdw 383 45 sensitization sensitization NN cord-020235-stcrozdw 383 46 of of IN cord-020235-stcrozdw 383 47 the the DT cord-020235-stcrozdw 383 48 erythrocytes erythrocyte NNS cord-020235-stcrozdw 383 49 . . . cord-020235-stcrozdw 384 1 -In -In . cord-020235-stcrozdw 385 1 the the DT cord-020235-stcrozdw 385 2 rubella rubella NN cord-020235-stcrozdw 385 3 SRH SRH NNP cord-020235-stcrozdw 385 4 - - HYPH cord-020235-stcrozdw 385 5 test test VBP cord-020235-stcrozdw 385 6 no no DT cord-020235-stcrozdw 385 7 improvement improvement NN cord-020235-stcrozdw 385 8 on on IN cord-020235-stcrozdw 385 9 regard regard NN cord-020235-stcrozdw 385 10 to to IN cord-020235-stcrozdw 385 11 sensitivity sensitivity NN cord-020235-stcrozdw 385 12 of of IN cord-020235-stcrozdw 385 13 the the DT cord-020235-stcrozdw 385 14 test test NN cord-020235-stcrozdw 385 15 was be VBD cord-020235-stcrozdw 385 16 seen see VBN cord-020235-stcrozdw 385 17 . . . cord-020235-stcrozdw 386 1 Moreover moreover RB cord-020235-stcrozdw 386 2 it -PRON- PRP cord-020235-stcrozdw 386 3 is be VBZ cord-020235-stcrozdw 386 4 not not RB cord-020235-stcrozdw 386 5 possible possible JJ cord-020235-stcrozdw 386 6 to to TO cord-020235-stcrozdw 386 7 detect detect VB cord-020235-stcrozdw 386 8 IgM IgM NNP cord-020235-stcrozdw 386 9 specific specific JJ cord-020235-stcrozdw 386 10 antibodies antibody NNS cord-020235-stcrozdw 386 11 after after IN cord-020235-stcrozdw 386 12 different different JJ cord-020235-stcrozdw 386 13 kinds kind NNS cord-020235-stcrozdw 386 14 of of IN cord-020235-stcrozdw 386 15 attachment attachment NN cord-020235-stcrozdw 386 16 in in IN cord-020235-stcrozdw 386 17 the the DT cord-020235-stcrozdw 386 18 SRH SRH NNP cord-020235-stcrozdw 386 19 - - HYPH cord-020235-stcrozdw 386 20 test test NN cord-020235-stcrozdw 386 21 . . . cord-020235-stcrozdw 387 1 -In -In . cord-020235-stcrozdw 388 1 the the DT cord-020235-stcrozdw 388 2 influenza influenza NN cord-020235-stcrozdw 388 3 SRH SRH NNP cord-020235-stcrozdw 388 4 - - HYPH cord-020235-stcrozdw 388 5 test test NN cord-020235-stcrozdw 388 6 with with IN cord-020235-stcrozdw 388 7 allantoic allantoic NNP cord-020235-stcrozdw 388 8 fluid fluid NN cord-020235-stcrozdw 388 9 of of IN cord-020235-stcrozdw 388 10 eggs egg NNS cord-020235-stcrozdw 388 11 infected infect VBN cord-020235-stcrozdw 388 12 with with IN cord-020235-stcrozdw 388 13 H h NN cord-020235-stcrozdw 388 14 3N2 3n2 CD cord-020235-stcrozdw 388 15 virus virus NN cord-020235-stcrozdw 389 1 it -PRON- PRP cord-020235-stcrozdw 389 2 was be VBD cord-020235-stcrozdw 389 3 possible possible JJ cord-020235-stcrozdw 389 4 to to TO cord-020235-stcrozdw 389 5 increase increase VB cord-020235-stcrozdw 389 6 the the DT cord-020235-stcrozdw 389 7 sensitivity sensitivity NN cord-020235-stcrozdw 389 8 with with IN cord-020235-stcrozdw 389 9 TOD TOD NNP cord-020235-stcrozdw 389 10 , , , cord-020235-stcrozdw 389 11 chromic chromic JJ cord-020235-stcrozdw 389 12 chloride chloride NN cord-020235-stcrozdw 389 13 and and CC cord-020235-stcrozdw 389 14 potassium potassium NN cord-020235-stcrozdw 389 15 periodate periodate NN cord-020235-stcrozdw 389 16 . . . cord-020235-stcrozdw 390 1 If if IN cord-020235-stcrozdw 390 2 tween tween NN cord-020235-stcrozdw 390 3 - - HYPH cord-020235-stcrozdw 390 4 ether ether NN cord-020235-stcrozdw 390 5 treated treat VBN cord-020235-stcrozdw 390 6 hemagglutinin hemagglutinin NN cord-020235-stcrozdw 390 7 was be VBD cord-020235-stcrozdw 390 8 used use VBN cord-020235-stcrozdw 390 9 only only RB cord-020235-stcrozdw 390 10 after after IN cord-020235-stcrozdw 390 11 sensitization sensitization NN cord-020235-stcrozdw 390 12 with with IN cord-020235-stcrozdw 390 13 TOD TOD NNP cord-020235-stcrozdw 390 14 , , , cord-020235-stcrozdw 390 15 chromic chromic JJ cord-020235-stcrozdw 390 16 chloride chloride NN cord-020235-stcrozdw 390 17 and and CC cord-020235-stcrozdw 390 18 periodate periodate JJ cord-020235-stcrozdw 390 19 hemolytic hemolytic JJ cord-020235-stcrozdw 390 20 zones zone NNS cord-020235-stcrozdw 390 21 were be VBD cord-020235-stcrozdw 390 22 detectable detectable JJ cord-020235-stcrozdw 390 23 . . . cord-020235-stcrozdw 391 1 Univ.-KinderkIinik Univ.-KinderkIinik NNP cord-020235-stcrozdw 391 2 , , , cord-020235-stcrozdw 391 3 Mathildenstr Mathildenstr NNP cord-020235-stcrozdw 391 4 . . . cord-020235-stcrozdw 392 1 1 1 CD cord-020235-stcrozdw 392 2 , , , cord-020235-stcrozdw 392 3 D-7800 d-7800 JJ cord-020235-stcrozdw 392 4 Freiburg Freiburg NNP cord-020235-stcrozdw 392 5 RNA RNA NNP cord-020235-stcrozdw 392 6 - - HYPH cord-020235-stcrozdw 392 7 Electropherotyping Electropherotyping NNP cord-020235-stcrozdw 392 8 of of IN cord-020235-stcrozdw 392 9 Human Human NNP cord-020235-stcrozdw 392 10 Rotaviruses Rotaviruses NNP cord-020235-stcrozdw 392 11 1978 1978 CD cord-020235-stcrozdw 392 12 . . . cord-020235-stcrozdw 393 1 and and CC cord-020235-stcrozdw 393 2 PASTOR PASTOR NNP cord-020235-stcrozdw 393 3 , , , cord-020235-stcrozdw 393 4 S. S. NNP cord-020235-stcrozdw 393 5 Rotaviruses Rotaviruses NNP cord-020235-stcrozdw 393 6 contain contain VBP cord-020235-stcrozdw 393 7 a a DT cord-020235-stcrozdw 393 8 double double RB cord-020235-stcrozdw 393 9 - - HYPH cord-020235-stcrozdw 393 10 stranded strand VBN cord-020235-stcrozdw 393 11 ribonucleic ribonucleic NN cord-020235-stcrozdw 393 12 acid acid NN cord-020235-stcrozdw 393 13 genome genome NN cord-020235-stcrozdw 393 14 consisting consist VBG cord-020235-stcrozdw 393 15 of of IN cord-020235-stcrozdw 393 16 11 11 CD cord-020235-stcrozdw 393 17 segments segment NNS cord-020235-stcrozdw 393 18 . . . cord-020235-stcrozdw 394 1 This this DT cord-020235-stcrozdw 394 2 can can MD cord-020235-stcrozdw 394 3 easily easily RB cord-020235-stcrozdw 394 4 be be VB cord-020235-stcrozdw 394 5 extracted extract VBN cord-020235-stcrozdw 394 6 from from IN cord-020235-stcrozdw 394 7 crude crude JJ cord-020235-stcrozdw 394 8 stool stool NN cord-020235-stcrozdw 394 9 suspension suspension NN cord-020235-stcrozdw 394 10 ( ( -LRB- cord-020235-stcrozdw 394 11 method method NN cord-020235-stcrozdw 394 12 by by IN cord-020235-stcrozdw 394 13 Rodger Rodger NNP cord-020235-stcrozdw 394 14 et et NNP cord-020235-stcrozdw 394 15 al al NNP cord-020235-stcrozdw 394 16 . . NNP cord-020235-stcrozdw 394 17 , , , cord-020235-stcrozdw 394 18 J. J. NNP cord-020235-stcrozdw 394 19 Clin Clin NNP cord-020235-stcrozdw 394 20 . . . cord-020235-stcrozdw 394 21 Microbial microbial JJ cord-020235-stcrozdw 394 22 . . . cord-020235-stcrozdw 394 23 1981 1981 CD cord-020235-stcrozdw 394 24 ) ) -RRB- cord-020235-stcrozdw 394 25 . . . cord-020235-stcrozdw 395 1 55 55 CD cord-020235-stcrozdw 395 2 out out IN cord-020235-stcrozdw 395 3 of of IN cord-020235-stcrozdw 395 4 210 210 CD cord-020235-stcrozdw 395 5 Rota Rota NNP cord-020235-stcrozdw 395 6 antigen antigen NN cord-020235-stcrozdw 395 7 positive positive JJ cord-020235-stcrozdw 395 8 samples sample NNS cord-020235-stcrozdw 395 9 contained contain VBD cord-020235-stcrozdw 395 10 sufficient sufficient JJ cord-020235-stcrozdw 395 11 RNA RNA NNP cord-020235-stcrozdw 395 12 to to TO cord-020235-stcrozdw 395 13 produce produce VB cord-020235-stcrozdw 395 14 a a DT cord-020235-stcrozdw 395 15 satisfying satisfying JJ cord-020235-stcrozdw 395 16 pattern pattern NN cord-020235-stcrozdw 395 17 in in IN cord-020235-stcrozdw 395 18 the the DT cord-020235-stcrozdw 395 19 SDS sds NN cord-020235-stcrozdw 395 20 - - HYPH cord-020235-stcrozdw 395 21 acrylamide acrylamide NN cord-020235-stcrozdw 395 22 - - HYPH cord-020235-stcrozdw 395 23 electrophoresis electrophoresis NN cord-020235-stcrozdw 395 24 . . . cord-020235-stcrozdw 396 1 We -PRON- PRP cord-020235-stcrozdw 396 2 demonstrate demonstrate VBP cord-020235-stcrozdw 396 3 six six CD cord-020235-stcrozdw 396 4 electropherotypes electropherotype NNS cord-020235-stcrozdw 396 5 with with IN cord-020235-stcrozdw 396 6 differences difference NNS cord-020235-stcrozdw 396 7 in in IN cord-020235-stcrozdw 396 8 the the DT cord-020235-stcrozdw 396 9 relative relative JJ cord-020235-stcrozdw 396 10 mobility mobility NN cord-020235-stcrozdw 396 11 of of IN cord-020235-stcrozdw 396 12 segments segment NNS cord-020235-stcrozdw 396 13 2 2 CD cord-020235-stcrozdw 396 14 , , , cord-020235-stcrozdw 396 15 3 3 CD cord-020235-stcrozdw 396 16 , , , cord-020235-stcrozdw 396 17 4 4 CD cord-020235-stcrozdw 396 18 , , , cord-020235-stcrozdw 396 19 5 5 CD cord-020235-stcrozdw 396 20 , , , cord-020235-stcrozdw 396 21 7 7 CD cord-020235-stcrozdw 396 22 , , , cord-020235-stcrozdw 396 23 8 8 CD cord-020235-stcrozdw 396 24 , , , cord-020235-stcrozdw 396 25 9 9 CD cord-020235-stcrozdw 396 26 , , , cord-020235-stcrozdw 396 27 11 11 CD cord-020235-stcrozdw 396 28 . . . cord-020235-stcrozdw 397 1 Of of IN cord-020235-stcrozdw 397 2 these these DT cord-020235-stcrozdw 397 3 diarrhea diarrhea NN cord-020235-stcrozdw 397 4 producing produce VBG cord-020235-stcrozdw 397 5 strains strain NNS cord-020235-stcrozdw 397 6 at at IN cord-020235-stcrozdw 397 7 least least JJS cord-020235-stcrozdw 397 8 two two CD cord-020235-stcrozdw 397 9 different different JJ cord-020235-stcrozdw 397 10 electropherotypes electropherotype NNS cord-020235-stcrozdw 397 11 were be VBD cord-020235-stcrozdw 397 12 found find VBN cord-020235-stcrozdw 397 13 during during IN cord-020235-stcrozdw 397 14 every every DT cord-020235-stcrozdw 397 15 outbreak outbreak NN cord-020235-stcrozdw 397 16 of of IN cord-020235-stcrozdw 397 17 Rotavirus rotavirus JJ cord-020235-stcrozdw 397 18 gastroenteritis gastroenteritis NN cord-020235-stcrozdw 397 19 . . . cord-020235-stcrozdw 398 1 Our -PRON- PRP$ cord-020235-stcrozdw 398 2 findings finding NNS cord-020235-stcrozdw 398 3 are be VBP cord-020235-stcrozdw 398 4 in in IN cord-020235-stcrozdw 398 5 good good JJ cord-020235-stcrozdw 398 6 agreement agreement NN cord-020235-stcrozdw 398 7 with with IN cord-020235-stcrozdw 398 8 the the DT cord-020235-stcrozdw 398 9 results result NNS cord-020235-stcrozdw 398 10 reported report VBN cord-020235-stcrozdw 398 11 by by IN cord-020235-stcrozdw 398 12 Rodger Rodger NNP cord-020235-stcrozdw 398 13 ) ) -RRB- cord-020235-stcrozdw 398 14 , , , cord-020235-stcrozdw 398 15 Espejo Espejo NNP cord-020235-stcrozdw 398 16 et et NNP cord-020235-stcrozdw 398 17 al al NNP cord-020235-stcrozdw 398 18 . . . cord-020235-stcrozdw 399 1 ( ( -LRB- cord-020235-stcrozdw 399 2 1980 1980 CD cord-020235-stcrozdw 399 3 ) ) -RRB- cord-020235-stcrozdw 399 4 , , . cord-020235-stcrozdw 400 1 and and CC cord-020235-stcrozdw 400 2 Kalica Kalica NNP cord-020235-stcrozdw 400 3 et et NNP cord-020235-stcrozdw 400 4 al al NNP cord-020235-stcrozdw 400 5 . . . cord-020235-stcrozdw 401 1 ( ( -LRB- cord-020235-stcrozdw 401 2 1978 1978 CD cord-020235-stcrozdw 401 3 , , , cord-020235-stcrozdw 401 4 1976 1976 CD cord-020235-stcrozdw 401 5 . . . cord-020235-stcrozdw 402 1 The the DT cord-020235-stcrozdw 402 2 so so RB cord-020235-stcrozdw 402 3 - - HYPH cord-020235-stcrozdw 402 4 called call VBN cord-020235-stcrozdw 402 5 M M NNP cord-020235-stcrozdw 402 6 - - HYPH cord-020235-stcrozdw 402 7 type type NN cord-020235-stcrozdw 402 8 of of IN cord-020235-stcrozdw 402 9 EMC EMC NNP cord-020235-stcrozdw 402 10 virus virus NN cord-020235-stcrozdw 402 11 is be VBZ cord-020235-stcrozdw 402 12 capable capable JJ cord-020235-stcrozdw 402 13 of of IN cord-020235-stcrozdw 402 14 inducing induce VBG cord-020235-stcrozdw 402 15 diabetes diabetes NN cord-020235-stcrozdw 402 16 mellitus mellitus NN cord-020235-stcrozdw 402 17 in in IN cord-020235-stcrozdw 402 18 mice mouse NNS cord-020235-stcrozdw 402 19 by by IN cord-020235-stcrozdw 402 20 a a DT cord-020235-stcrozdw 402 21 selective selective JJ cord-020235-stcrozdw 402 22 B b NN cord-020235-stcrozdw 402 23 cell cell NN cord-020235-stcrozdw 402 24 damage damage NN cord-020235-stcrozdw 402 25 . . . cord-020235-stcrozdw 403 1 The the DT cord-020235-stcrozdw 403 2 M M NNP cord-020235-stcrozdw 403 3 - - HYPH cord-020235-stcrozdw 403 4 EMC EMC NNP cord-020235-stcrozdw 403 5 strain strain NN cord-020235-stcrozdw 403 6 used use VBN cord-020235-stcrozdw 403 7 in in IN cord-020235-stcrozdw 403 8 our -PRON- PRP$ cord-020235-stcrozdw 403 9 laboratory laboratory NN cord-020235-stcrozdw 403 10 has have VBZ cord-020235-stcrozdw 403 11 partially partially RB cord-020235-stcrozdw 403 12 lost lose VBN cord-020235-stcrozdw 403 13 this this DT cord-020235-stcrozdw 403 14 capacity capacity NN cord-020235-stcrozdw 403 15 . . . cord-020235-stcrozdw 404 1 We -PRON- PRP cord-020235-stcrozdw 404 2 attempted attempt VBD cord-020235-stcrozdw 404 3 to to TO cord-020235-stcrozdw 404 4 reisolate reisolate VB cord-020235-stcrozdw 404 5 a a DT cord-020235-stcrozdw 404 6 diabetogenic diabetogenic NNP cord-020235-stcrozdw 404 7 variant variant NN cord-020235-stcrozdw 404 8 and and CC cord-020235-stcrozdw 404 9 to to TO cord-020235-stcrozdw 404 10 elucidate elucidate VB cord-020235-stcrozdw 404 11 the the DT cord-020235-stcrozdw 404 12 causes cause NNS cord-020235-stcrozdw 404 13 of of IN cord-020235-stcrozdw 404 14 the the DT cord-020235-stcrozdw 404 15 change change NN cord-020235-stcrozdw 404 16 . . . cord-020235-stcrozdw 405 1 Seven seven CD cord-020235-stcrozdw 405 2 serial serial JJ cord-020235-stcrozdw 405 3 heart heart NN cord-020235-stcrozdw 405 4 passages passage NNS cord-020235-stcrozdw 405 5 in in IN cord-020235-stcrozdw 405 6 mice mouse NNS cord-020235-stcrozdw 405 7 did do VBD cord-020235-stcrozdw 405 8 not not RB cord-020235-stcrozdw 405 9 enrich enrich VB cord-020235-stcrozdw 405 10 such such PDT cord-020235-stcrozdw 405 11 a a DT cord-020235-stcrozdw 405 12 variant variant NN cord-020235-stcrozdw 405 13 . . . cord-020235-stcrozdw 406 1 Cloning clone VBG cord-020235-stcrozdw 406 2 of of IN cord-020235-stcrozdw 406 3 the the DT cord-020235-stcrozdw 406 4 virus virus NN cord-020235-stcrozdw 406 5 stock stock NN cord-020235-stcrozdw 406 6 yielded yield VBD cord-020235-stcrozdw 406 7 one one CD cord-020235-stcrozdw 406 8 clone clone NN cord-020235-stcrozdw 406 9 diabetogenic diabetogenic NNP cord-020235-stcrozdw 406 10 in in IN cord-020235-stcrozdw 406 11 two two CD cord-020235-stcrozdw 406 12 of of IN cord-020235-stcrozdw 406 13 ten ten CD cord-020235-stcrozdw 406 14 animals animal NNS cord-020235-stcrozdw 406 15 ( ( -LRB- cord-020235-stcrozdw 406 16 5 5 CD cord-020235-stcrozdw 406 17 clones clone NNS cord-020235-stcrozdw 406 18 tested test VBN cord-020235-stcrozdw 406 19 so so RB cord-020235-stcrozdw 406 20 far far RB cord-020235-stcrozdw 406 21 ) ) -RRB- cord-020235-stcrozdw 406 22 , , , cord-020235-stcrozdw 406 23 -In -In . cord-020235-stcrozdw 407 1 a a DT cord-020235-stcrozdw 407 2 different different JJ cord-020235-stcrozdw 407 3 substrain substrain NN cord-020235-stcrozdw 407 4 of of IN cord-020235-stcrozdw 407 5 M M NNP cord-020235-stcrozdw 407 6 - - HYPH cord-020235-stcrozdw 407 7 ECM ECM NNP cord-020235-stcrozdw 407 8 virus virus NN cord-020235-stcrozdw 407 9 ( ( -LRB- cord-020235-stcrozdw 407 10 the the DT cord-020235-stcrozdw 407 11 highly highly RB cord-020235-stcrozdw 407 12 diabetogenic diabetogenic NNP cord-020235-stcrozdw 407 13 Dvariant Dvariant NNP cord-020235-stcrozdw 407 14 , , , cord-020235-stcrozdw 407 15 obtained obtain VBN cord-020235-stcrozdw 407 16 from from IN cord-020235-stcrozdw 407 17 Dr. Dr. NNP cord-020235-stcrozdw 407 18 Petersen Petersen NNP cord-020235-stcrozdw 407 19 ) ) -RRB- cord-020235-stcrozdw 408 1 we -PRON- PRP cord-020235-stcrozdw 408 2 found find VBD cord-020235-stcrozdw 408 3 both both DT cord-020235-stcrozdw 408 4 diabetogenic diabetogenic JJ cord-020235-stcrozdw 408 5 and and CC cord-020235-stcrozdw 408 6 non non JJ cord-020235-stcrozdw 408 7 - - JJ cord-020235-stcrozdw 408 8 diabetogenic diabetogenic JJ cord-020235-stcrozdw 408 9 clones clone NNS cord-020235-stcrozdw 408 10 . . . cord-020235-stcrozdw 409 1 Incidence incidence NN cord-020235-stcrozdw 409 2 and and CC cord-020235-stcrozdw 409 3 severity severity NN cord-020235-stcrozdw 409 4 of of IN cord-020235-stcrozdw 409 5 diabetes diabetes NN cord-020235-stcrozdw 409 6 has have VBZ cord-020235-stcrozdw 409 7 been be VBN cord-020235-stcrozdw 409 8 shown show VBN cord-020235-stcrozdw 409 9 to to TO cord-020235-stcrozdw 409 10 be be VB cord-020235-stcrozdw 409 11 age age NN cord-020235-stcrozdw 409 12 - - HYPH cord-020235-stcrozdw 409 13 related relate VBN cord-020235-stcrozdw 409 14 . . . cord-020235-stcrozdw 410 1 T T NNP cord-020235-stcrozdw 410 2 his -PRON- PRP$ cord-020235-stcrozdw 410 3 safety safety NN cord-020235-stcrozdw 410 4 study study NN cord-020235-stcrozdw 410 5 was be VBD cord-020235-stcrozdw 410 6 to to TO cord-020235-stcrozdw 410 7 demonstrate demonstrate VB cord-020235-stcrozdw 410 8 whether whether IN cord-020235-stcrozdw 410 9 or or CC cord-020235-stcrozdw 410 10 not not RB cord-020235-stcrozdw 410 11 granulosis granulosis NNP cord-020235-stcrozdw 410 12 virus virus NN cord-020235-stcrozdw 410 13 ( ( -LRB- cord-020235-stcrozdw 410 14 GV GV NNP cord-020235-stcrozdw 410 15 ) ) -RRB- cord-020235-stcrozdw 410 16 of of IN cord-020235-stcrozdw 410 17 Laspeyresia Laspeyresia NNP cord-020235-stcrozdw 410 18 pomonella pomonella NNP cord-020235-stcrozdw 410 19 can can MD cord-020235-stcrozdw 410 20 rep rep VB cord-020235-stcrozdw 410 21 licate licate NNP cord-020235-stcrozdw 410 22 in in IN cord-020235-stcrozdw 410 23 vertebrates vertebrate NNS cord-020235-stcrozdw 410 24 . . . cord-020235-stcrozdw 411 1 After after IN cord-020235-stcrozdw 411 2 feeding feed VBG cord-020235-stcrozdw 411 3 GV GV NNP cord-020235-stcrozdw 411 4 to to IN cord-020235-stcrozdw 411 5 NMRI NMRI NNP cord-020235-stcrozdw 411 6 - - HYPH cord-020235-stcrozdw 411 7 mice mouse NNS cord-020235-stcrozdw 411 8 , , , cord-020235-stcrozdw 411 9 no no DT cord-020235-stcrozdw 411 10 virus virus NN cord-020235-stcrozdw 411 11 induced induce VBN cord-020235-stcrozdw 411 12 antibodies antibody NNS cord-020235-stcrozdw 411 13 could could MD cord-020235-stcrozdw 411 14 be be VB cord-020235-stcrozdw 411 15 detected detect VBN cord-020235-stcrozdw 411 16 within within IN cord-020235-stcrozdw 411 17 eighty eighty CD cord-020235-stcrozdw 411 18 days day NNS cord-020235-stcrozdw 411 19 by by IN cord-020235-stcrozdw 411 20 radioimmunoassay radioimmunoassay JJ cord-020235-stcrozdw 411 21 ( ( -LRB- cord-020235-stcrozdw 411 22 RIA RIA NNP cord-020235-stcrozdw 411 23 ) ) -RRB- cord-020235-stcrozdw 411 24 and and CC cord-020235-stcrozdw 411 25 no no DT cord-020235-stcrozdw 411 26 vertical vertical JJ cord-020235-stcrozdw 411 27 virus virus NN cord-020235-stcrozdw 411 28 transmission transmission NN cord-020235-stcrozdw 411 29 was be VBD cord-020235-stcrozdw 411 30 observed observe VBN cord-020235-stcrozdw 411 31 . . . cord-020235-stcrozdw 412 1 GV GV NNP cord-020235-stcrozdw 412 2 did do VBD cord-020235-stcrozdw 412 3 not not RB cord-020235-stcrozdw 412 4 replicate replicate VB cord-020235-stcrozdw 412 5 in in IN cord-020235-stcrozdw 412 6 mice mouse NNS cord-020235-stcrozdw 412 7 . . . cord-020235-stcrozdw 413 1 Human Human NNP cord-020235-stcrozdw 413 2 sera sera NNP cord-020235-stcrozdw 413 3 , , , cord-020235-stcrozdw 413 4 as as RB cord-020235-stcrozdw 413 5 well well RB cord-020235-stcrozdw 413 6 as as IN cord-020235-stcrozdw 413 7 sera sera NNP cord-020235-stcrozdw 413 8 from from IN cord-020235-stcrozdw 413 9 horses horse NNS cord-020235-stcrozdw 413 10 , , , cord-020235-stcrozdw 413 11 cattle cattle NNS cord-020235-stcrozdw 413 12 , , , cord-020235-stcrozdw 413 13 sheep sheep NNS cord-020235-stcrozdw 413 14 and and CC cord-020235-stcrozdw 413 15 swine swine NN cord-020235-stcrozdw 413 16 reacted react VBD cord-020235-stcrozdw 413 17 with with IN cord-020235-stcrozdw 413 18 GV GV NNP cord-020235-stcrozdw 413 19 in in IN cord-020235-stcrozdw 413 20 the the DT cord-020235-stcrozdw 413 21 RIA RIA NNP cord-020235-stcrozdw 413 22 . . . cord-020235-stcrozdw 414 1 By by IN cord-020235-stcrozdw 414 2 characterization characterization NN cord-020235-stcrozdw 414 3 the the DT cord-020235-stcrozdw 414 4 positive positive JJ cord-020235-stcrozdw 414 5 reacting react VBG cord-020235-stcrozdw 414 6 human human JJ cord-020235-stcrozdw 414 7 immunoglobulin immunoglobulin NN cord-020235-stcrozdw 414 8 c1ass(es c1ass(es NNP cord-020235-stcrozdw 414 9 ) ) -RRB- cord-020235-stcrozdw 414 10 , , , cord-020235-stcrozdw 414 11 IgG IgG NNP cord-020235-stcrozdw 414 12 showed show VBD cord-020235-stcrozdw 414 13 the the DT cord-020235-stcrozdw 414 14 strongest strong JJS cord-020235-stcrozdw 414 15 positive positive JJ cord-020235-stcrozdw 414 16 reaction reaction NN cord-020235-stcrozdw 414 17 , , , cord-020235-stcrozdw 414 18 less less RBR cord-020235-stcrozdw 414 19 positive positive JJ cord-020235-stcrozdw 414 20 reactions reaction NNS cord-020235-stcrozdw 414 21 were be VBD cord-020235-stcrozdw 414 22 shown show VBN cord-020235-stcrozdw 414 23 by by IN cord-020235-stcrozdw 414 24 IgE IgE NNP cord-020235-stcrozdw 414 25 and and CC cord-020235-stcrozdw 414 26 IgM IgM NNP cord-020235-stcrozdw 414 27 and and CC cord-020235-stcrozdw 414 28 no no DT cord-020235-stcrozdw 414 29 reaction reaction NN cord-020235-stcrozdw 414 30 by by IN cord-020235-stcrozdw 414 31 IgA IgA NNP cord-020235-stcrozdw 414 32 and and CC cord-020235-stcrozdw 414 33 IgD. IgD. NNP cord-020235-stcrozdw 415 1 By by IN cord-020235-stcrozdw 415 2 concentrating concentrate VBG cord-020235-stcrozdw 415 3 the the DT cord-020235-stcrozdw 415 4 immunoglobulins immunoglobulin NNS cord-020235-stcrozdw 415 5 of of IN cord-020235-stcrozdw 415 6 the the DT cord-020235-stcrozdw 415 7 negative negative JJ cord-020235-stcrozdw 415 8 reacting react VBG cord-020235-stcrozdw 415 9 sera sera NNP cord-020235-stcrozdw 415 10 to to IN cord-020235-stcrozdw 415 11 250 250 CD cord-020235-stcrozdw 415 12 pg pg NNP cord-020235-stcrozdw 415 13 IgG IgG NNP cord-020235-stcrozdw 415 14 / / SYM cord-020235-stcrozdw 415 15 ml ml XX cord-020235-stcrozdw 415 16 , , , cord-020235-stcrozdw 415 17 all all DT cord-020235-stcrozdw 415 18 sera sera NNP cord-020235-stcrozdw 415 19 could could MD cord-020235-stcrozdw 415 20 be be VB cord-020235-stcrozdw 415 21 recognized recognize VBN cord-020235-stcrozdw 415 22 as as IN cord-020235-stcrozdw 415 23 positive positive JJ cord-020235-stcrozdw 415 24 . . . cord-020235-stcrozdw 416 1 Thus thus RB cord-020235-stcrozdw 416 2 a a DT cord-020235-stcrozdw 416 3 non non JJ cord-020235-stcrozdw 416 4 - - JJ cord-020235-stcrozdw 416 5 immunological immunological JJ cord-020235-stcrozdw 416 6 reaction reaction NN cord-020235-stcrozdw 416 7 has have VBZ cord-020235-stcrozdw 416 8 been be VBN cord-020235-stcrozdw 416 9 suggested suggest VBN cord-020235-stcrozdw 416 10 . . . cord-020235-stcrozdw 417 1 Infection infection NN cord-020235-stcrozdw 417 2 of of IN cord-020235-stcrozdw 417 3 human human JJ cord-020235-stcrozdw 417 4 fibroblasts fibroblast NNS cord-020235-stcrozdw 417 5 with with IN cord-020235-stcrozdw 417 6 cytomegalovirus cytomegalovirus NNP cord-020235-stcrozdw 417 7 induces induce VBZ cord-020235-stcrozdw 417 8 typical typical JJ cord-020235-stcrozdw 417 9 cytopathic cytopathic JJ cord-020235-stcrozdw 417 10 alterations alteration NNS cord-020235-stcrozdw 417 11 . . . cord-020235-stcrozdw 418 1 Cell cell NN cord-020235-stcrozdw 418 2 rounding round VBG cord-020235-stcrozdw 418 3 within within IN cord-020235-stcrozdw 418 4 5 5 CD cord-020235-stcrozdw 418 5 - - SYM cord-020235-stcrozdw 418 6 6 6 CD cord-020235-stcrozdw 418 7 h h NN cord-020235-stcrozdw 418 8 postinfection postinfection NN cord-020235-stcrozdw 418 9 ( ( -LRB- cord-020235-stcrozdw 418 10 p.i p.i NNP cord-020235-stcrozdw 418 11 . . NNP cord-020235-stcrozdw 418 12 ) ) -RRB- cord-020235-stcrozdw 418 13 is be VBZ cord-020235-stcrozdw 418 14 followed follow VBN cord-020235-stcrozdw 418 15 by by IN cord-020235-stcrozdw 418 16 an an DT cord-020235-stcrozdw 418 17 increase increase NN cord-020235-stcrozdw 418 18 in in IN cord-020235-stcrozdw 418 19 cell cell NN cord-020235-stcrozdw 418 20 size size NN cord-020235-stcrozdw 418 21 , , , cord-020235-stcrozdw 418 22 appearance appearance NN cord-020235-stcrozdw 418 23 of of IN cord-020235-stcrozdw 418 24 cytoplasmic cytoplasmic JJ cord-020235-stcrozdw 418 25 and and CC cord-020235-stcrozdw 418 26 nuclear nuclear JJ cord-020235-stcrozdw 418 27 inclusions inclusion NNS cord-020235-stcrozdw 418 28 and and CC cord-020235-stcrozdw 418 29 a a DT cord-020235-stcrozdw 418 30 morphological morphological JJ cord-020235-stcrozdw 418 31 change change NN cord-020235-stcrozdw 418 32 to to IN cord-020235-stcrozdw 418 33 an an DT cord-020235-stcrozdw 418 34 epitheloid epitheloid NNP cord-020235-stcrozdw 418 35 cell cell NN cord-020235-stcrozdw 418 36 shape shape NN cord-020235-stcrozdw 418 37 by by IN cord-020235-stcrozdw 418 38 48 48 CD cord-020235-stcrozdw 418 39 h h NN cord-020235-stcrozdw 418 40 p.i p.i NNP cord-020235-stcrozdw 418 41 . . . cord-020235-stcrozdw 419 1 In in IN cord-020235-stcrozdw 419 2 order order NN cord-020235-stcrozdw 419 3 to to TO cord-020235-stcrozdw 419 4 elucidate elucidate VB cord-020235-stcrozdw 419 5 the the DT cord-020235-stcrozdw 419 6 participation participation NN cord-020235-stcrozdw 419 7 of of IN cord-020235-stcrozdw 419 8 the the DT cord-020235-stcrozdw 419 9 cytoskeleton cytoskeleton NN cord-020235-stcrozdw 419 10 in in IN cord-020235-stcrozdw 419 11 this this DT cord-020235-stcrozdw 419 12 alteration alteration NN cord-020235-stcrozdw 419 13 of of IN cord-020235-stcrozdw 419 14 cell cell NN cord-020235-stcrozdw 419 15 morphology morphology NN cord-020235-stcrozdw 419 16 experiments experiment NNS cord-020235-stcrozdw 419 17 were be VBD cord-020235-stcrozdw 419 18 initiated initiate VBN cord-020235-stcrozdw 419 19 in in IN cord-020235-stcrozdw 419 20 serum serum NN cord-020235-stcrozdw 419 21 - - HYPH cord-020235-stcrozdw 419 22 starved starve VBN cord-020235-stcrozdw 419 23 human human JJ cord-020235-stcrozdw 419 24 fibroblasts fibroblast NNS cord-020235-stcrozdw 419 25 to to TO cord-020235-stcrozdw 419 26 visualize visualize VB cord-020235-stcrozdw 419 27 changes change NNS cord-020235-stcrozdw 419 28 in in IN cord-020235-stcrozdw 419 29 actin actin NN cord-020235-stcrozdw 419 30 arrangement arrangement NN cord-020235-stcrozdw 419 31 by by IN cord-020235-stcrozdw 419 32 indirect indirect JJ cord-020235-stcrozdw 419 33 immunofluorescence immunofluorescence NN cord-020235-stcrozdw 419 34 . . . cord-020235-stcrozdw 420 1 A a DT cord-020235-stcrozdw 420 2 early early JJ cord-020235-stcrozdw 420 3 as as IN cord-020235-stcrozdw 420 4 3 3 CD cord-020235-stcrozdw 420 5 h h NN cord-020235-stcrozdw 420 6 p.i p.i NNP cord-020235-stcrozdw 420 7 . . . cord-020235-stcrozdw 420 8 cytoplasmic cytoplasmic JJ cord-020235-stcrozdw 420 9 microfilamenrs microfilamenrs NNP cord-020235-stcrozdw 420 10 had have VBD cord-020235-stcrozdw 420 11 shortened shorten VBN cord-020235-stcrozdw 420 12 and and CC cord-020235-stcrozdw 420 13 were be VBD cord-020235-stcrozdw 420 14 rearranged rearrange VBN cord-020235-stcrozdw 420 15 to to IN cord-020235-stcrozdw 420 16 a a DT cord-020235-stcrozdw 420 17 more more RBR cord-020235-stcrozdw 420 18 irregular irregular JJ cord-020235-stcrozdw 420 19 pattern pattern NN cord-020235-stcrozdw 420 20 . . . cord-020235-stcrozdw 421 1 At at IN cord-020235-stcrozdw 421 2 12 12 CD cord-020235-stcrozdw 421 3 h h NN cord-020235-stcrozdw 421 4 p.i p.i NNP cord-020235-stcrozdw 421 5 . . NNP cord-020235-stcrozdw 421 6 actin actin NN cord-020235-stcrozdw 421 7 fibers fiber NNS cord-020235-stcrozdw 421 8 were be VBD cord-020235-stcrozdw 421 9 absent absent JJ cord-020235-stcrozdw 421 10 from from IN cord-020235-stcrozdw 421 11 rounded rounded JJ cord-020235-stcrozdw 421 12 cells cell NNS cord-020235-stcrozdw 421 13 . . . cord-020235-stcrozdw 422 1 The the DT cord-020235-stcrozdw 422 2 same same JJ cord-020235-stcrozdw 422 3 was be VBD cord-020235-stcrozdw 422 4 observed observe VBN cord-020235-stcrozdw 422 5 in in IN cord-020235-stcrozdw 422 6 epitheloid epitheloid NNP cord-020235-stcrozdw 422 7 cells cell NNS cord-020235-stcrozdw 422 8 at at IN cord-020235-stcrozdw 422 9 48 48 CD cord-020235-stcrozdw 422 10 h h NN cord-020235-stcrozdw 422 11 p.i p.i NNP cord-020235-stcrozdw 422 12 . . . cord-020235-stcrozdw 422 13 Cultivation cultivation NN cord-020235-stcrozdw 422 14 of of IN cord-020235-stcrozdw 422 15 infected infected JJ cord-020235-stcrozdw 422 16 cells cell NNS cord-020235-stcrozdw 422 17 with with IN cord-020235-stcrozdw 422 18 phosphonoacetic phosphonoacetic JJ cord-020235-stcrozdw 422 19 acid acid NN cord-020235-stcrozdw 422 20 resulted result VBD cord-020235-stcrozdw 422 21 in in IN cord-020235-stcrozdw 422 22 a a DT cord-020235-stcrozdw 422 23 partial partial JJ cord-020235-stcrozdw 422 24 preservation preservation NN cord-020235-stcrozdw 422 25 of of IN cord-020235-stcrozdw 422 26 the the DT cord-020235-stcrozdw 422 27 normal normal JJ cord-020235-stcrozdw 422 28 actin actin NN cord-020235-stcrozdw 422 29 fiber fiber NN cord-020235-stcrozdw 422 30 distribution distribution NN cord-020235-stcrozdw 422 31 . . . cord-020235-stcrozdw 423 1 In in IN cord-020235-stcrozdw 423 2 contrast contrast NN cord-020235-stcrozdw 423 3 , , , cord-020235-stcrozdw 423 4 infected infected JJ cord-020235-stcrozdw 423 5 cells cell NNS cord-020235-stcrozdw 423 6 did do VBD cord-020235-stcrozdw 423 7 not not RB cord-020235-stcrozdw 423 8 exhibit exhibit VB cord-020235-stcrozdw 423 9 major major JJ cord-020235-stcrozdw 423 10 changes change NNS cord-020235-stcrozdw 423 11 in in IN cord-020235-stcrozdw 423 12 actin actin NN cord-020235-stcrozdw 423 13 synthesis synthesis NN cord-020235-stcrozdw 423 14 as as IN cord-020235-stcrozdw 423 15 estimated estimate VBN cord-020235-stcrozdw 423 16 from from IN cord-020235-stcrozdw 423 17 the the DT cord-020235-stcrozdw 423 18 specific specific JJ cord-020235-stcrozdw 423 19 radioactivity radioactivity NN cord-020235-stcrozdw 423 20 of of IN cord-020235-stcrozdw 423 21 cytoplasmic cytoplasmic JJ cord-020235-stcrozdw 423 22 actin actin NN cord-020235-stcrozdw 423 23 isolated isolate VBN cord-020235-stcrozdw 423 24 from from IN cord-020235-stcrozdw 423 25 3H 3h CD cord-020235-stcrozdw 423 26 - - HYPH cord-020235-stcrozdw 423 27 leucine leucine NN cord-020235-stcrozdw 423 28 pulse pulse NN cord-020235-stcrozdw 423 29 labelled label VBN cord-020235-stcrozdw 423 30 infected infected JJ cord-020235-stcrozdw 423 31 cells cell NNS cord-020235-stcrozdw 423 32 by by IN cord-020235-stcrozdw 423 33 DNAase DNAase NNP cord-020235-stcrozdw 423 34 I I NNP cord-020235-stcrozdw 423 35 - - HYPH cord-020235-stcrozdw 423 36 Sepharose Sepharose NNP cord-020235-stcrozdw 423 37 affinity affinity NN cord-020235-stcrozdw 423 38 chromatography chromatography NN cord-020235-stcrozdw 423 39 and and CC cord-020235-stcrozdw 423 40 SDSpolyacrylamide sdspolyacrylamide NN cord-020235-stcrozdw 423 41 electrophoresis electrophoresis NN cord-020235-stcrozdw 423 42 with with IN cord-020235-stcrozdw 423 43 fluorography fluorography NN cord-020235-stcrozdw 423 44 . . . cord-020235-stcrozdw 424 1 Chicken chicken NN cord-020235-stcrozdw 424 2 erythrocytes erythrocyte NNS cord-020235-stcrozdw 424 3 were be VBD cord-020235-stcrozdw 424 4 coated coat VBN cord-020235-stcrozdw 424 5 with with IN cord-020235-stcrozdw 424 6 glycine glycine NN cord-020235-stcrozdw 424 7 - - HYPH cord-020235-stcrozdw 424 8 extracted extract VBN cord-020235-stcrozdw 424 9 CMV CMV NNP cord-020235-stcrozdw 424 10 antigen antigen NN cord-020235-stcrozdw 424 11 and and CC cord-020235-stcrozdw 424 12 negative negative JJ cord-020235-stcrozdw 424 13 control control NN cord-020235-stcrozdw 424 14 antigen antigen NN cord-020235-stcrozdw 424 15 by by IN cord-020235-stcrozdw 424 16 treatment treatment NN cord-020235-stcrozdw 424 17 with with IN cord-020235-stcrozdw 424 18 formaldehyde formaldehyde NN cord-020235-stcrozdw 424 19 and and CC cord-020235-stcrozdw 424 20 CrCl CrCl NNP cord-020235-stcrozdw 424 21 s s NNP cord-020235-stcrozdw 424 22 and and CC cord-020235-stcrozdw 424 23 were be VBD cord-020235-stcrozdw 424 24 used use VBN cord-020235-stcrozdw 424 25 for for IN cord-020235-stcrozdw 424 26 detection detection NN cord-020235-stcrozdw 424 27 of of IN cord-020235-stcrozdw 424 28 CMV CMV NNP cord-020235-stcrozdw 424 29 specific specific JJ cord-020235-stcrozdw 424 30 serum serum NN cord-020235-stcrozdw 424 31 antibodies antibody NNS cord-020235-stcrozdw 424 32 in in IN cord-020235-stcrozdw 424 33 PHA PHA NNP cord-020235-stcrozdw 424 34 tests test NNS cord-020235-stcrozdw 424 35 . . . cord-020235-stcrozdw 425 1 Their -PRON- PRP$ cord-020235-stcrozdw 425 2 sensitivity sensitivity NN cord-020235-stcrozdw 425 3 was be VBD cord-020235-stcrozdw 425 4 proven prove VBN cord-020235-stcrozdw 425 5 to to TO cord-020235-stcrozdw 425 6 be be VB cord-020235-stcrozdw 425 7 in in IN cord-020235-stcrozdw 425 8 good good JJ cord-020235-stcrozdw 425 9 agreement agreement NN cord-020235-stcrozdw 425 10 and and CC cord-020235-stcrozdw 425 11 their -PRON- PRP$ cord-020235-stcrozdw 425 12 specificity specificity NN cord-020235-stcrozdw 425 13 superior superior JJ cord-020235-stcrozdw 425 14 to to IN cord-020235-stcrozdw 425 15 results result NNS cord-020235-stcrozdw 425 16 seen see VBN cord-020235-stcrozdw 425 17 in in IN cord-020235-stcrozdw 425 18 CFT CFT NNP cord-020235-stcrozdw 425 19 . . . cord-020235-stcrozdw 426 1 IgM IgM NNP cord-020235-stcrozdw 426 2 - - HYPH cord-020235-stcrozdw 426 3 specific specific JJ cord-020235-stcrozdw 426 4 CMV CMV NNP cord-020235-stcrozdw 426 5 antibody antibody NN cord-020235-stcrozdw 426 6 detection detection NN cord-020235-stcrozdw 426 7 was be VBD cord-020235-stcrozdw 426 8 performed perform VBN cord-020235-stcrozdw 426 9 either either CC cord-020235-stcrozdw 426 10 after after IN cord-020235-stcrozdw 426 11 a a DT cord-020235-stcrozdw 426 12 simple simple JJ cord-020235-stcrozdw 426 13 and and CC cord-020235-stcrozdw 426 14 rapid rapid JJ cord-020235-stcrozdw 426 15 DEAE DEAE NNP cord-020235-stcrozdw 426 16 - - HYPH cord-020235-stcrozdw 426 17 cellulose cellulose NN cord-020235-stcrozdw 426 18 exchange exchange NN cord-020235-stcrozdw 426 19 chromatography chromatography NN cord-020235-stcrozdw 426 20 of of IN cord-020235-stcrozdw 426 21 serum serum NN cord-020235-stcrozdw 426 22 samples sample NNS cord-020235-stcrozdw 426 23 or or CC cord-020235-stcrozdw 426 24 by by IN cord-020235-stcrozdw 426 25 IgG IgG NNP cord-020235-stcrozdw 426 26 immunoprecipitation immunoprecipitation NN cord-020235-stcrozdw 426 27 combined combine VBN cord-020235-stcrozdw 426 28 with with IN cord-020235-stcrozdw 426 29 ME ME NNP cord-020235-stcrozdw 426 30 - - HYPH cord-020235-stcrozdw 426 31 reduction reduction NN cord-020235-stcrozdw 426 32 controls control NNS cord-020235-stcrozdw 426 33 . . . cord-020235-stcrozdw 427 1 The the DT cord-020235-stcrozdw 427 2 main main JJ cord-020235-stcrozdw 427 3 advantage advantage NN cord-020235-stcrozdw 427 4 of of IN cord-020235-stcrozdw 427 5 the the DT cord-020235-stcrozdw 427 6 modified modify VBN cord-020235-stcrozdw 427 7 CMV CMV NNP cord-020235-stcrozdw 427 8 - - HYPH cord-020235-stcrozdw 427 9 PHAT PHAT NNP cord-020235-stcrozdw 427 10 was be VBD cord-020235-stcrozdw 427 11 seen see VBN cord-020235-stcrozdw 427 12 in in IN cord-020235-stcrozdw 427 13 the the DT cord-020235-stcrozdw 427 14 stability stability NN cord-020235-stcrozdw 427 15 of of IN cord-020235-stcrozdw 427 16 sensitized sensitize VBN cord-020235-stcrozdw 427 17 erythrocytes erythrocyte NNS cord-020235-stcrozdw 427 18 , , , cord-020235-stcrozdw 427 19 which which WDT cord-020235-stcrozdw 427 20 can can MD cord-020235-stcrozdw 427 21 be be VB cord-020235-stcrozdw 427 22 lyophilized lyophilize VBN cord-020235-stcrozdw 427 23 . . . cord-020235-stcrozdw 428 1 LANVERS LANVERS NNP cord-020235-stcrozdw 428 2 , , , cord-020235-stcrozdw 428 3 A. A. NNP cord-020235-stcrozdw 428 4 , , , cord-020235-stcrozdw 428 5 MERTENS MERTENS NNP cord-020235-stcrozdw 428 6 , , , cord-020235-stcrozdw 428 7 TH TH NNP cord-020235-stcrozdw 428 8 . . NNP cord-020235-stcrozdw 428 9 , , , cord-020235-stcrozdw 428 10 and and CC cord-020235-stcrozdw 428 11 EGGERS EGGERS NNP cord-020235-stcrozdw 428 12 , , , cord-020235-stcrozdw 428 13 H. H. NNP cord-020235-stcrozdw 428 14 J. J. NNP cord-020235-stcrozdw 429 1 There there EX cord-020235-stcrozdw 429 2 are be VBP cord-020235-stcrozdw 429 3 reports report NNS cord-020235-stcrozdw 429 4 that that IN cord-020235-stcrozdw 429 5 herpes herpes NNP cord-020235-stcrozdw 429 6 simplex simplex NNP cord-020235-stcrozdw 429 7 virus virus NN cord-020235-stcrozdw 429 8 ( ( -LRB- cord-020235-stcrozdw 429 9 HSV HSV NNP cord-020235-stcrozdw 429 10 ) ) -RRB- cord-020235-stcrozdw 429 11 could could MD cord-020235-stcrozdw 429 12 be be VB cord-020235-stcrozdw 429 13 isolated isolate VBN cord-020235-stcrozdw 429 14 from from IN cord-020235-stcrozdw 429 15 the the DT cord-020235-stcrozdw 429 16 genitourinary genitourinary JJ cord-020235-stcrozdw 429 17 tract tract NN cord-020235-stcrozdw 429 18 of of IN cord-020235-stcrozdw 429 19 up up IN cord-020235-stcrozdw 429 20 to to TO cord-020235-stcrozdw 429 21 15 15 CD cord-020235-stcrozdw 429 22 Ofo Ofo NNP cord-020235-stcrozdw 429 23 of of IN cord-020235-stcrozdw 429 24 males male NNS cord-020235-stcrozdw 429 25 without without IN cord-020235-stcrozdw 429 26 manifest manifest NN cord-020235-stcrozdw 429 27 herpes herpes NN cord-020235-stcrozdw 429 28 . . . cord-020235-stcrozdw 430 1 In in IN cord-020235-stcrozdw 430 2 order order NN cord-020235-stcrozdw 430 3 to to TO cord-020235-stcrozdw 430 4 confirm confirm VB cord-020235-stcrozdw 430 5 these these DT cord-020235-stcrozdw 430 6 results result NNS cord-020235-stcrozdw 430 7 we -PRON- PRP cord-020235-stcrozdw 430 8 first first RB cord-020235-stcrozdw 430 9 wanted want VBD cord-020235-stcrozdw 430 10 to to TO cord-020235-stcrozdw 430 11 establish establish VB cord-020235-stcrozdw 430 12 a a DT cord-020235-stcrozdw 430 13 method method NN cord-020235-stcrozdw 430 14 for for IN cord-020235-stcrozdw 430 15 typing type VBG cord-020235-stcrozdw 430 16 possible possible JJ cord-020235-stcrozdw 430 17 HSV HSV NNP cord-020235-stcrozdw 430 18 isolates isolate NNS cord-020235-stcrozdw 430 19 . . . cord-020235-stcrozdw 431 1 We -PRON- PRP cord-020235-stcrozdw 431 2 used use VBD cord-020235-stcrozdw 431 3 3 3 CD cord-020235-stcrozdw 431 4 published publish VBN cord-020235-stcrozdw 431 5 methods method NNS cord-020235-stcrozdw 431 6 : : : cord-020235-stcrozdw 431 7 a a DT cord-020235-stcrozdw 431 8 plaque plaque NN cord-020235-stcrozdw 431 9 test test NN cord-020235-stcrozdw 431 10 in in IN cord-020235-stcrozdw 431 11 chick chick NN cord-020235-stcrozdw 431 12 embryo embryo NN cord-020235-stcrozdw 431 13 cells cell NNS cord-020235-stcrozdw 431 14 , , , cord-020235-stcrozdw 431 15 a a DT cord-020235-stcrozdw 431 16 neutralisation neutralisation NN cord-020235-stcrozdw 431 17 test test NN cord-020235-stcrozdw 431 18 , , , cord-020235-stcrozdw 431 19 and and CC cord-020235-stcrozdw 431 20 the the DT cord-020235-stcrozdw 431 21 analysis analysis NN cord-020235-stcrozdw 431 22 of of IN cord-020235-stcrozdw 431 23 the the DT cord-020235-stcrozdw 431 24 early early JJ cord-020235-stcrozdw 431 25 HSV HSV NNP cord-020235-stcrozdw 431 26 - - HYPH cord-020235-stcrozdw 431 27 proteins protein NNS cord-020235-stcrozdw 431 28 ( ( -LRB- cord-020235-stcrozdw 431 29 SDS SDS NNP cord-020235-stcrozdw 431 30 - - HYPH cord-020235-stcrozdw 431 31 PAGE PAGE NNP cord-020235-stcrozdw 431 32 ) ) -RRB- cord-020235-stcrozdw 431 33 . . . cord-020235-stcrozdw 432 1 All all DT cord-020235-stcrozdw 432 2 3 3 CD cord-020235-stcrozdw 432 3 methods method NNS cord-020235-stcrozdw 432 4 yielded yield VBD cord-020235-stcrozdw 432 5 identical identical JJ cord-020235-stcrozdw 432 6 results result NNS cord-020235-stcrozdw 432 7 . . . cord-020235-stcrozdw 433 1 We -PRON- PRP cord-020235-stcrozdw 433 2 then then RB cord-020235-stcrozdw 433 3 tried try VBD cord-020235-stcrozdw 433 4 to to TO cord-020235-stcrozdw 433 5 isolate isolate VB cord-020235-stcrozdw 433 6 HSV HSV NNP cord-020235-stcrozdw 433 7 from from IN cord-020235-stcrozdw 433 8 192 192 CD cord-020235-stcrozdw 433 9 materials material NNS cord-020235-stcrozdw 433 10 of of IN cord-020235-stcrozdw 433 11 181 181 CD cord-020235-stcrozdw 433 12 asymptomatic asymptomatic JJ cord-020235-stcrozdw 433 13 males male NNS cord-020235-stcrozdw 433 14 ( ( -LRB- cord-020235-stcrozdw 433 15 89 89 CD cord-020235-stcrozdw 433 16 urethral urethral JJ cord-020235-stcrozdw 433 17 swabs swab NNS cord-020235-stcrozdw 433 18 , , , cord-020235-stcrozdw 433 19 55 55 CD cord-020235-stcrozdw 433 20 seminal seminal JJ cord-020235-stcrozdw 433 21 fluids fluid NNS cord-020235-stcrozdw 433 22 , , , cord-020235-stcrozdw 433 23 48 48 CD cord-020235-stcrozdw 433 24 fresh fresh JJ cord-020235-stcrozdw 433 25 tissue tissue NN cord-020235-stcrozdw 433 26 probes probe NNS cord-020235-stcrozdw 433 27 ) ) -RRB- cord-020235-stcrozdw 433 28 . . . cord-020235-stcrozdw 434 1 All all DT cord-020235-stcrozdw 434 2 materials material NNS cord-020235-stcrozdw 434 3 were be VBD cord-020235-stcrozdw 434 4 immediately immediately RB cord-020235-stcrozdw 434 5 inoculated inoculate VBN cord-020235-stcrozdw 434 6 into into IN cord-020235-stcrozdw 434 7 tube tube NN cord-020235-stcrozdw 434 8 cultures culture NNS cord-020235-stcrozdw 434 9 of of IN cord-020235-stcrozdw 434 10 two two CD cord-020235-stcrozdw 434 11 cell cell NN cord-020235-stcrozdw 434 12 lines line NNS cord-020235-stcrozdw 434 13 shown show VBN cord-020235-stcrozdw 434 14 to to TO cord-020235-stcrozdw 434 15 be be VB cord-020235-stcrozdw 434 16 highly highly RB cord-020235-stcrozdw 434 17 HSV HSV NNP cord-020235-stcrozdw 434 18 - - HYPH cord-020235-stcrozdw 434 19 susceptible susceptible JJ cord-020235-stcrozdw 434 20 . . . cord-020235-stcrozdw 435 1 Additionally additionally RB cord-020235-stcrozdw 435 2 , , , cord-020235-stcrozdw 435 3 the the DT cord-020235-stcrozdw 435 4 tissue tissue NN cord-020235-stcrozdw 435 5 probes probe NNS cord-020235-stcrozdw 435 6 were be VBD cord-020235-stcrozdw 435 7 co co JJ cord-020235-stcrozdw 435 8 - - VBN cord-020235-stcrozdw 435 9 cultivated cultivate VBN cord-020235-stcrozdw 435 10 with with IN cord-020235-stcrozdw 435 11 permissive permissive JJ cord-020235-stcrozdw 435 12 cells cell NNS cord-020235-stcrozdw 435 13 . . . cord-020235-stcrozdw 436 1 We -PRON- PRP cord-020235-stcrozdw 436 2 also also RB cord-020235-stcrozdw 436 3 induced induce VBD cord-020235-stcrozdw 436 4 cell cell NN cord-020235-stcrozdw 436 5 fusion fusion NN cord-020235-stcrozdw 436 6 ( ( -LRB- cord-020235-stcrozdw 436 7 PEG PEG NNP cord-020235-stcrozdw 436 8 ) ) -RRB- cord-020235-stcrozdw 436 9 in in IN cord-020235-stcrozdw 436 10 such such JJ cord-020235-stcrozdw 436 11 cocultures coculture NNS cord-020235-stcrozdw 436 12 . . . cord-020235-stcrozdw 437 1 Despite despite IN cord-020235-stcrozdw 437 2 all all DT cord-020235-stcrozdw 437 3 efforts effort NNS cord-020235-stcrozdw 437 4 we -PRON- PRP cord-020235-stcrozdw 437 5 did do VBD cord-020235-stcrozdw 437 6 not not RB cord-020235-stcrozdw 437 7 isolate isolate VB cord-020235-stcrozdw 437 8 any any DT cord-020235-stcrozdw 437 9 virus virus NN cord-020235-stcrozdw 437 10 from from IN cord-020235-stcrozdw 437 11 all all PDT cord-020235-stcrozdw 437 12 these these DT cord-020235-stcrozdw 437 13 materials material NNS cord-020235-stcrozdw 437 14 . . . cord-020235-stcrozdw 438 1 For for IN cord-020235-stcrozdw 438 2 an an DT cord-020235-stcrozdw 438 3 experimental experimental JJ cord-020235-stcrozdw 438 4 approach approach NN cord-020235-stcrozdw 438 5 to to TO cord-020235-stcrozdw 438 6 answer answer VB cord-020235-stcrozdw 438 7 the the DT cord-020235-stcrozdw 438 8 question question NN cord-020235-stcrozdw 438 9 as as IN cord-020235-stcrozdw 438 10 to to IN cord-020235-stcrozdw 438 11 which which WDT cord-020235-stcrozdw 438 12 viral viral JJ cord-020235-stcrozdw 438 13 genes gene NNS cord-020235-stcrozdw 438 14 may may MD cord-020235-stcrozdw 438 15 control control VB cord-020235-stcrozdw 438 16 pathogenesis pathogenesis NN cord-020235-stcrozdw 438 17 after after IN cord-020235-stcrozdw 438 18 peripheral peripheral JJ cord-020235-stcrozdw 438 19 infection infection NN cord-020235-stcrozdw 438 20 of of IN cord-020235-stcrozdw 438 21 inbred inbred JJ cord-020235-stcrozdw 438 22 mice mouse NNS cord-020235-stcrozdw 438 23 with with IN cord-020235-stcrozdw 438 24 HSV HSV NNP cord-020235-stcrozdw 438 25 , , , cord-020235-stcrozdw 438 26 we -PRON- PRP cord-020235-stcrozdw 438 27 have have VBP cord-020235-stcrozdw 438 28 isolated isolate VBN cord-020235-stcrozdw 438 29 a a DT cord-020235-stcrozdw 438 30 variant variant JJ cord-020235-stcrozdw 438 31 strain strain NN cord-020235-stcrozdw 438 32 ( ( -LRB- cord-020235-stcrozdw 438 33 ANG ang NN cord-020235-stcrozdw 438 34 - - HYPH cord-020235-stcrozdw 438 35 path path NN cord-020235-stcrozdw 438 36 ) ) -RRB- cord-020235-stcrozdw 438 37 that that WDT cord-020235-stcrozdw 438 38 proved prove VBD cord-020235-stcrozdw 438 39 highly highly RB cord-020235-stcrozdw 438 40 neuropathogenic neuropathogenic JJ cord-020235-stcrozdw 438 41 both both DT cord-020235-stcrozdw 438 42 upon upon IN cord-020235-stcrozdw 438 43 i.p i.p NNP cord-020235-stcrozdw 438 44 . . NNP cord-020235-stcrozdw 438 45 -or -or : cord-020235-stcrozdw 438 46 intravaginal intravaginal JJ cord-020235-stcrozdw 438 47 infection infection NN cord-020235-stcrozdw 438 48 from from IN cord-020235-stcrozdw 438 49 the the DT cord-020235-stcrozdw 438 50 apathogenic apathogenic NNP cord-020235-stcrozdw 438 51 strain strain NN cord-020235-stcrozdw 438 52 HSV-1 HSV-1 NNP cord-020235-stcrozdw 438 53 ANG ANG NNP cord-020235-stcrozdw 438 54 . . . cord-020235-stcrozdw 439 1 Two two CD cord-020235-stcrozdw 439 2 alterations alteration NNS cord-020235-stcrozdw 439 3 of of IN cord-020235-stcrozdw 439 4 the the DT cord-020235-stcrozdw 439 5 ANG ANG NNP cord-020235-stcrozdw 439 6 genome genome NN cord-020235-stcrozdw 439 7 have have VBP cord-020235-stcrozdw 439 8 been be VBN cord-020235-stcrozdw 439 9 detected detect VBN cord-020235-stcrozdw 439 10 by by IN cord-020235-stcrozdw 439 11 restriction restriction NN cord-020235-stcrozdw 439 12 enzyme enzyme NN cord-020235-stcrozdw 439 13 analysis analysis NN cord-020235-stcrozdw 439 14 : : : cord-020235-stcrozdw 439 15 the the DT cord-020235-stcrozdw 439 16 loss loss NN cord-020235-stcrozdw 439 17 of of IN cord-020235-stcrozdw 439 18 the the DT cord-020235-stcrozdw 439 19 amplifiable amplifiable JJ cord-020235-stcrozdw 439 20 500 500 CD cord-020235-stcrozdw 439 21 b.p b.p NNP cord-020235-stcrozdw 439 22 . . NNP cord-020235-stcrozdw 439 23 nucleotide nucleotide JJ cord-020235-stcrozdw 439 24 sequence sequence NN cord-020235-stcrozdw 439 25 typical typical JJ cord-020235-stcrozdw 439 26 for for IN cord-020235-stcrozdw 439 27 ANG ANG NNP cord-020235-stcrozdw 439 28 and and CC cord-020235-stcrozdw 439 29 a a DT cord-020235-stcrozdw 439 30 400 400 CD cord-020235-stcrozdw 439 31 b.p b.p NNP cord-020235-stcrozdw 439 32 , , , cord-020235-stcrozdw 439 33 deletion deletion NN cord-020235-stcrozdw 439 34 approximately approximately RB cord-020235-stcrozdw 439 35 at at IN cord-020235-stcrozdw 439 36 the the DT cord-020235-stcrozdw 439 37 position position NN cord-020235-stcrozdw 439 38 mapped map VBN cord-020235-stcrozdw 439 39 for for IN cord-020235-stcrozdw 439 40 the the DT cord-020235-stcrozdw 439 41 structural structural JJ cord-020235-stcrozdw 439 42 viral viral JJ cord-020235-stcrozdw 439 43 glyco glyco NNP cord-020235-stcrozdw 439 44 - - HYPH cord-020235-stcrozdw 439 45 protein protein NN cord-020235-stcrozdw 439 46 D. D. NNP cord-020235-stcrozdw 440 1 Despite despite IN cord-020235-stcrozdw 440 2 the the DT cord-020235-stcrozdw 440 3 induction induction NN cord-020235-stcrozdw 440 4 of of IN cord-020235-stcrozdw 440 5 interferon interferon NN cord-020235-stcrozdw 440 6 and and CC cord-020235-stcrozdw 440 7 NK nk NN cord-020235-stcrozdw 440 8 - - HYPH cord-020235-stcrozdw 440 9 cells cell NNS cord-020235-stcrozdw 440 10 both both DT cord-020235-stcrozdw 440 11 variants variant NNS cord-020235-stcrozdw 440 12 multiply multiply VBP cord-020235-stcrozdw 440 13 to to IN cord-020235-stcrozdw 440 14 a a DT cord-020235-stcrozdw 440 15 similar similar JJ cord-020235-stcrozdw 440 16 extent extent NN cord-020235-stcrozdw 440 17 , , , cord-020235-stcrozdw 440 18 probably probably RB cord-020235-stcrozdw 440 19 in in IN cord-020235-stcrozdw 440 20 the the DT cord-020235-stcrozdw 440 21 same same JJ cord-020235-stcrozdw 440 22 target target NN cord-020235-stcrozdw 440 23 cells cell NNS cord-020235-stcrozdw 440 24 of of IN cord-020235-stcrozdw 440 25 the the DT cord-020235-stcrozdw 440 26 peritoneum peritoneum NN cord-020235-stcrozdw 440 27 . . . cord-020235-stcrozdw 441 1 The the DT cord-020235-stcrozdw 441 2 spread spread NN cord-020235-stcrozdw 441 3 from from IN cord-020235-stcrozdw 441 4 the the DT cord-020235-stcrozdw 441 5 peritoneum peritoneum NN cord-020235-stcrozdw 441 6 , , , cord-020235-stcrozdw 441 7 spleen spleen NN cord-020235-stcrozdw 441 8 , , , cord-020235-stcrozdw 441 9 liver liver NN cord-020235-stcrozdw 441 10 , , , cord-020235-stcrozdw 441 11 thymus thymus NN cord-020235-stcrozdw 441 12 and and CC cord-020235-stcrozdw 441 13 local local JJ cord-020235-stcrozdw 441 14 lymph lymph NN cord-020235-stcrozdw 441 15 nodes node NNS cord-020235-stcrozdw 441 16 to to IN cord-020235-stcrozdw 441 17 the the DT cord-020235-stcrozdw 441 18 eNS ens NN cord-020235-stcrozdw 441 19 seems seem VBZ cord-020235-stcrozdw 441 20 , , , cord-020235-stcrozdw 441 21 however however RB cord-020235-stcrozdw 441 22 , , , cord-020235-stcrozdw 441 23 to to TO cord-020235-stcrozdw 441 24 be be VB cord-020235-stcrozdw 441 25 controlled control VBN cord-020235-stcrozdw 441 26 by by IN cord-020235-stcrozdw 441 27 the the DT cord-020235-stcrozdw 441 28 action action NN cord-020235-stcrozdw 441 29 of of IN cord-020235-stcrozdw 441 30 gene gene NN cord-020235-stcrozdw 441 31 products product NNS cord-020235-stcrozdw 441 32 coded code VBN cord-020235-stcrozdw 441 33 for for IN cord-020235-stcrozdw 441 34 in in IN cord-020235-stcrozdw 441 35 only only RB cord-020235-stcrozdw 441 36 one one CD cord-020235-stcrozdw 441 37 of of IN cord-020235-stcrozdw 441 38 the the DT cord-020235-stcrozdw 441 39 variants variant NNS cord-020235-stcrozdw 441 40 . . . cord-020235-stcrozdw 442 1 Div Div NNP cord-020235-stcrozdw 442 2 , , , cord-020235-stcrozdw 442 3 of of IN cord-020235-stcrozdw 442 4 expo expo NNP cord-020235-stcrozdw 442 5 Virology Virology NNP cord-020235-stcrozdw 442 6 , , , cord-020235-stcrozdw 442 7 Insr Insr NNP cord-020235-stcrozdw 442 8 , , , cord-020235-stcrozdw 442 9 for for IN cord-020235-stcrozdw 442 10 Med Med NNP cord-020235-stcrozdw 442 11 . . . cord-020235-stcrozdw 443 1 Microbiology Microbiology NNP cord-020235-stcrozdw 443 2 , , , cord-020235-stcrozdw 443 3 Univ Univ NNP cord-020235-stcrozdw 443 4 . . NNP cord-020235-stcrozdw 443 5 , , , cord-020235-stcrozdw 444 1 D-6500 d-6500 LS cord-020235-stcrozdw 445 1 Mainz Mainz NNP cord-020235-stcrozdw 445 2 KNOBLICH KNOBLICH NNP cord-020235-stcrozdw 445 3 , , , cord-020235-stcrozdw 445 4 A. A. NNP cord-020235-stcrozdw 445 5 , , , cord-020235-stcrozdw 445 6 FRIEDRICH FRIEDRICH NNP cord-020235-stcrozdw 445 7 , , , cord-020235-stcrozdw 445 8 D. D. NNP cord-020235-stcrozdw 445 9 , , , cord-020235-stcrozdw 445 10 GOERTZ GOERTZ NNP cord-020235-stcrozdw 445 11 , , , cord-020235-stcrozdw 445 12 ] ] -RRB- cord-020235-stcrozdw 445 13 . . . cord-020235-stcrozdw 446 1 , , , cord-020235-stcrozdw 446 2 and and CC cord-020235-stcrozdw 446 3 FALKE FALKE NNP cord-020235-stcrozdw 446 4 , , , cord-020235-stcrozdw 446 5 D. D. NNP cord-020235-stcrozdw 446 6 Herpesviruses Herpesviruses NNP cord-020235-stcrozdw 446 7 are be VBP cord-020235-stcrozdw 446 8 known know VBN cord-020235-stcrozdw 446 9 to to TO cord-020235-stcrozdw 446 10 cause cause VB cord-020235-stcrozdw 446 11 infections infection NNS cord-020235-stcrozdw 446 12 in in IN cord-020235-stcrozdw 446 13 men man NNS cord-020235-stcrozdw 446 14 and and CC cord-020235-stcrozdw 446 15 animals animal NNS cord-020235-stcrozdw 446 16 . . . cord-020235-stcrozdw 447 1 Strong strong JJ cord-020235-stcrozdw 447 2 differences difference NNS cord-020235-stcrozdw 447 3 in in IN cord-020235-stcrozdw 447 4 resistance resistance NN cord-020235-stcrozdw 447 5 to to IN cord-020235-stcrozdw 447 6 Herpes Herpes NNP cord-020235-stcrozdw 447 7 simplex simplex NN cord-020235-stcrozdw 447 8 virus virus NN cord-020235-stcrozdw 447 9 ( ( -LRB- cord-020235-stcrozdw 447 10 HSV-1 hsv-1 NN cord-020235-stcrozdw 447 11 ) ) -RRB- cord-020235-stcrozdw 447 12 are be VBP cord-020235-stcrozdw 447 13 noted note VBN cord-020235-stcrozdw 447 14 among among IN cord-020235-stcrozdw 447 15 mice mouse NNS cord-020235-stcrozdw 447 16 of of IN cord-020235-stcrozdw 447 17 various various JJ cord-020235-stcrozdw 447 18 strains strain NNS cord-020235-stcrozdw 447 19 . . . cord-020235-stcrozdw 448 1 Anti anti JJ cord-020235-stcrozdw 448 2 - - JJ cord-020235-stcrozdw 448 3 HSV hsv JJ cord-020235-stcrozdw 448 4 - - HYPH cord-020235-stcrozdw 448 5 activity activity NN cord-020235-stcrozdw 448 6 of of IN cord-020235-stcrozdw 448 7 T T NNP cord-020235-stcrozdw 448 8 - - HYPH cord-020235-stcrozdw 448 9 Iymphocytes Iymphocytes NNP cord-020235-stcrozdw 448 10 , , , cord-020235-stcrozdw 448 11 macrophages macrophage NNS cord-020235-stcrozdw 448 12 and and CC cord-020235-stcrozdw 448 13 NK NK NNP cord-020235-stcrozdw 448 14 cells cell NNS cord-020235-stcrozdw 448 15 has have VBZ cord-020235-stcrozdw 448 16 been be VBN cord-020235-stcrozdw 448 17 demonstrated demonstrate VBN cord-020235-stcrozdw 448 18 in in IN cord-020235-stcrozdw 448 19 the the DT cord-020235-stcrozdw 448 20 last last JJ cord-020235-stcrozdw 448 21 years year NNS cord-020235-stcrozdw 448 22 . . . cord-020235-stcrozdw 449 1 Our -PRON- PRP$ cord-020235-stcrozdw 449 2 interest interest NN cord-020235-stcrozdw 449 3 was be VBD cord-020235-stcrozdw 449 4 focused focus VBN cord-020235-stcrozdw 449 5 on on IN cord-020235-stcrozdw 449 6 neutralizing neutralize VBG cord-020235-stcrozdw 449 7 antibodies antibody NNS cord-020235-stcrozdw 449 8 in in IN cord-020235-stcrozdw 449 9 primary primary JJ cord-020235-stcrozdw 449 10 HSV-1 HSV-1 NNP cord-020235-stcrozdw 449 11 Abstracts abstract NNS cord-020235-stcrozdw 449 12 of of IN cord-020235-stcrozdw 449 13 the the DT cord-020235-stcrozdw 449 14 38 38 CD cord-020235-stcrozdw 449 15 th th NNP cord-020235-stcrozdw 449 16 Meeting Meeting NNP cord-020235-stcrozdw 449 17 of of IN cord-020235-stcrozdw 449 18 the the DT cord-020235-stcrozdw 449 19 OGHM OGHM NNP cord-020235-stcrozdw 449 20 infections infection NNS cord-020235-stcrozdw 449 21 of of IN cord-020235-stcrozdw 449 22 mice mouse NNS cord-020235-stcrozdw 449 23 . . . cord-020235-stcrozdw 450 1 Antibodies antibody NNS cord-020235-stcrozdw 450 2 become become VBP cord-020235-stcrozdw 450 3 detectable detectable JJ cord-020235-stcrozdw 450 4 by by IN cord-020235-stcrozdw 450 5 day day NN cord-020235-stcrozdw 450 6 5 5 CD cord-020235-stcrozdw 450 7 after after IN cord-020235-stcrozdw 450 8 infection infection NN cord-020235-stcrozdw 450 9 and and CC cord-020235-stcrozdw 450 10 reach reach VB cord-020235-stcrozdw 450 11 a a DT cord-020235-stcrozdw 450 12 plateau plateau NN cord-020235-stcrozdw 450 13 level level NN cord-020235-stcrozdw 450 14 at at IN cord-020235-stcrozdw 450 15 day day NN cord-020235-stcrozdw 450 16 21 21 CD cord-020235-stcrozdw 450 17 , , , cord-020235-stcrozdw 450 18 the the DT cord-020235-stcrozdw 450 19 day day NN cord-020235-stcrozdw 450 20 we -PRON- PRP cord-020235-stcrozdw 450 21 chose choose VBD cord-020235-stcrozdw 450 22 to to TO cord-020235-stcrozdw 450 23 test test VB cord-020235-stcrozdw 450 24 the the DT cord-020235-stcrozdw 450 25 sera sera NNP cord-020235-stcrozdw 450 26 . . . cord-020235-stcrozdw 451 1 Comparison comparison NN cord-020235-stcrozdw 451 2 of of IN cord-020235-stcrozdw 451 3 antibody antibody NN cord-020235-stcrozdw 451 4 titers titer NNS cord-020235-stcrozdw 451 5 in in IN cord-020235-stcrozdw 451 6 18 18 CD cord-020235-stcrozdw 451 7 strains strain NNS cord-020235-stcrozdw 451 8 of of IN cord-020235-stcrozdw 451 9 mice mouse NNS cord-020235-stcrozdw 451 10 revealed reveal VBD cord-020235-stcrozdw 451 11 titers titer NNS cord-020235-stcrozdw 451 12 always always RB cord-020235-stcrozdw 451 13 to to TO cord-020235-stcrozdw 451 14 be be VB cord-020235-stcrozdw 451 15 higher high JJR cord-020235-stcrozdw 451 16 in in IN cord-020235-stcrozdw 451 17 female female JJ cord-020235-stcrozdw 451 18 mice mouse NNS cord-020235-stcrozdw 451 19 , , , cord-020235-stcrozdw 451 20 whereas whereas IN cord-020235-stcrozdw 451 21 no no DT cord-020235-stcrozdw 451 22 clear clear JJ cord-020235-stcrozdw 451 23 influence influence NN cord-020235-stcrozdw 451 24 of of IN cord-020235-stcrozdw 451 25 either either DT cord-020235-stcrozdw 451 26 H-2-haplotype H-2-haplotype NNP cord-020235-stcrozdw 451 27 or or CC cord-020235-stcrozdw 451 28 background background NN cord-020235-stcrozdw 451 29 genome genome NN cord-020235-stcrozdw 451 30 could could MD cord-020235-stcrozdw 451 31 be be VB cord-020235-stcrozdw 451 32 detected detect VBN cord-020235-stcrozdw 451 33 . . . cord-020235-stcrozdw 452 1 Sexual sexual JJ cord-020235-stcrozdw 452 2 steroids steroid NNS cord-020235-stcrozdw 452 3 produced produce VBN cord-020235-stcrozdw 452 4 in in IN cord-020235-stcrozdw 452 5 ovaries ovary NNS cord-020235-stcrozdw 452 6 and and CC cord-020235-stcrozdw 452 7 testes testis NNS cord-020235-stcrozdw 452 8 were be VBD cord-020235-stcrozdw 452 9 identified identify VBN cord-020235-stcrozdw 452 10 to to TO cord-020235-stcrozdw 452 11 exert exert VB cord-020235-stcrozdw 452 12 influence influence NN cord-020235-stcrozdw 452 13 on on IN cord-020235-stcrozdw 452 14 antibody antibody NN cord-020235-stcrozdw 452 15 formation formation NN cord-020235-stcrozdw 452 16 by by IN cord-020235-stcrozdw 452 17 castration castration NN cord-020235-stcrozdw 452 18 experiments experiment NNS cord-020235-stcrozdw 452 19 . . . cord-020235-stcrozdw 453 1 Treatment treatment NN cord-020235-stcrozdw 453 2 of of IN cord-020235-stcrozdw 453 3 mice mouse NNS cord-020235-stcrozdw 453 4 with with IN cord-020235-stcrozdw 453 5 silica silica NN cord-020235-stcrozdw 453 6 once once RB cord-020235-stcrozdw 453 7 between between IN cord-020235-stcrozdw 453 8 day day NN cord-020235-stcrozdw 453 9 1 1 CD cord-020235-stcrozdw 453 10 before before RB cord-020235-stcrozdw 453 11 and and CC cord-020235-stcrozdw 453 12 day day NN cord-020235-stcrozdw 453 13 12 12 CD cord-020235-stcrozdw 453 14 after after IN cord-020235-stcrozdw 453 15 infection infection NN cord-020235-stcrozdw 453 16 resulted result VBD cord-020235-stcrozdw 453 17 in in IN cord-020235-stcrozdw 453 18 a a DT cord-020235-stcrozdw 453 19 strong strong JJ cord-020235-stcrozdw 453 20 increase increase NN cord-020235-stcrozdw 453 21 of of IN cord-020235-stcrozdw 453 22 antibody antibody NN cord-020235-stcrozdw 453 23 titers titer NNS cord-020235-stcrozdw 453 24 both both DT cord-020235-stcrozdw 453 25 in in IN cord-020235-stcrozdw 453 26 females female NNS cord-020235-stcrozdw 453 27 and and CC cord-020235-stcrozdw 453 28 males male NNS cord-020235-stcrozdw 453 29 at at IN cord-020235-stcrozdw 453 30 the the DT cord-020235-stcrozdw 453 31 same same JJ cord-020235-stcrozdw 453 32 time time NN cord-020235-stcrozdw 453 33 abolishing abolish VBG cord-020235-stcrozdw 453 34 the the DT cord-020235-stcrozdw 453 35 difference difference NN cord-020235-stcrozdw 453 36 in in IN cord-020235-stcrozdw 453 37 antibody antibody NN cord-020235-stcrozdw 453 38 titers titer NNS cord-020235-stcrozdw 453 39 between between IN cord-020235-stcrozdw 453 40 the the DT cord-020235-stcrozdw 453 41 sexes sex NNS cord-020235-stcrozdw 453 42 . . . cord-020235-stcrozdw 454 1 Silica silica NN cord-020235-stcrozdw 454 2 could could MD cord-020235-stcrozdw 454 3 enhance enhance VB cord-020235-stcrozdw 454 4 antibody antibody NN cord-020235-stcrozdw 454 5 levels level NNS cord-020235-stcrozdw 454 6 also also RB cord-020235-stcrozdw 454 7 after after IN cord-020235-stcrozdw 454 8 immunisation immunisation NN cord-020235-stcrozdw 454 9 of of IN cord-020235-stcrozdw 454 10 mice mouse NNS cord-020235-stcrozdw 454 11 with with IN cord-020235-stcrozdw 454 12 a a DT cord-020235-stcrozdw 454 13 formol formol JJ cord-020235-stcrozdw 454 14 - - HYPH cord-020235-stcrozdw 454 15 inactivated inactivate VBN cord-020235-stcrozdw 454 16 HSV HSV NNP cord-020235-stcrozdw 454 17 - - HYPH cord-020235-stcrozdw 454 18 vaccine vaccine NN cord-020235-stcrozdw 454 19 . . . cord-020235-stcrozdw 455 1 Bestatin Bestatin NNP cord-020235-stcrozdw 455 2 is be VBZ cord-020235-stcrozdw 455 3 a a DT cord-020235-stcrozdw 455 4 small small JJ cord-020235-stcrozdw 455 5 peptide peptide NN cord-020235-stcrozdw 455 6 known know VBN cord-020235-stcrozdw 455 7 - - : cord-020235-stcrozdw 455 8 selectively selectively RB cord-020235-stcrozdw 455 9 to to TO cord-020235-stcrozdw 455 10 stimulate stimulate VB cord-020235-stcrozdw 455 11 DNA dna NN cord-020235-stcrozdw 455 12 metabolism metabolism NN cord-020235-stcrozdw 455 13 in in IN cord-020235-stcrozdw 455 14 T t NN cord-020235-stcrozdw 455 15 - - HYPH cord-020235-stcrozdw 455 16 lymphocytes lymphocyte NNS cord-020235-stcrozdw 455 17 and and CC cord-020235-stcrozdw 455 18 to to TO cord-020235-stcrozdw 455 19 enhance enhance VB cord-020235-stcrozdw 455 20 HSV HSV NNP cord-020235-stcrozdw 455 21 - - HYPH cord-020235-stcrozdw 455 22 antibody antibody NN cord-020235-stcrozdw 455 23 -titers -titer VBZ cord-020235-stcrozdw 455 24 maximally maximally RB cord-020235-stcrozdw 455 25 when when WRB cord-020235-stcrozdw 455 26 given give VBN cord-020235-stcrozdw 455 27 at at IN cord-020235-stcrozdw 455 28 day day NN cord-020235-stcrozdw 455 29 5 5 CD cord-020235-stcrozdw 455 30 after after IN cord-020235-stcrozdw 455 31 infection infection NN cord-020235-stcrozdw 455 32 . . . cord-020235-stcrozdw 456 1 After after IN cord-020235-stcrozdw 456 2 pretreatment pretreatment NN cord-020235-stcrozdw 456 3 of of IN cord-020235-stcrozdw 456 4 mice mouse NNS cord-020235-stcrozdw 456 5 with with IN cord-020235-stcrozdw 456 6 silica silica NN cord-020235-stcrozdw 456 7 the the DT cord-020235-stcrozdw 456 8 antibody antibody NN cord-020235-stcrozdw 456 9 augmenting augment VBG cord-020235-stcrozdw 456 10 effect effect NN cord-020235-stcrozdw 456 11 is be VBZ cord-020235-stcrozdw 456 12 already already RB cord-020235-stcrozdw 456 13 achieved achieve VBN cord-020235-stcrozdw 456 14 at at IN cord-020235-stcrozdw 456 15 day day NN cord-020235-stcrozdw 456 16 1 1 CD cord-020235-stcrozdw 456 17 after after IN cord-020235-stcrozdw 456 18 infection infection NN cord-020235-stcrozdw 456 19 . . . cord-020235-stcrozdw 457 1 In in IN cord-020235-stcrozdw 457 2 secondary secondary JJ cord-020235-stcrozdw 457 3 HSV HSV NNP cord-020235-stcrozdw 457 4 - - HYPH cord-020235-stcrozdw 457 5 l l NN cord-020235-stcrozdw 457 6 infection infection NN cord-020235-stcrozdw 457 7 Bestatin Bestatin NNP cord-020235-stcrozdw 457 8 acts act VBZ cord-020235-stcrozdw 457 9 best good JJS cord-020235-stcrozdw 457 10 1 1 CD cord-020235-stcrozdw 457 11 day day NN cord-020235-stcrozdw 457 12 after after IN cord-020235-stcrozdw 457 13 infection infection NN cord-020235-stcrozdw 457 14 , , , cord-020235-stcrozdw 457 15 too too RB cord-020235-stcrozdw 457 16 . . . cord-020235-stcrozdw 458 1 Insr Insr NNP cord-020235-stcrozdw 458 2 . . . cord-020235-stcrozdw 459 1 f. f. NNP cord-020235-stcrozdw 459 2 Med Med NNP cord-020235-stcrozdw 459 3 . . . cord-020235-stcrozdw 460 1 Virologie Virologie NNP cord-020235-stcrozdw 460 2 d. d. NNP cord-020235-stcrozdw 460 3 Univ Univ NNP cord-020235-stcrozdw 460 4 . . . cord-020235-stcrozdw 461 1 , , , cord-020235-stcrozdw 461 2 0 0 CD cord-020235-stcrozdw 461 3 - - : cord-020235-stcrozdw 461 4 6900 6900 CD cord-020235-stcrozdw 461 5 Heidelberg Heidelberg NNP cord-020235-stcrozdw 461 6 Induction Induction NNP cord-020235-stcrozdw 461 7 and and CC cord-020235-stcrozdw 461 8 Characterization Characterization NNP cord-020235-stcrozdw 461 9 of of IN cord-020235-stcrozdw 461 10 Herpes Herpes NNP cord-020235-stcrozdw 461 11 Simplex Simplex NNP cord-020235-stcrozdw 461 12 Virus Virus NNP cord-020235-stcrozdw 461 13 Reisolates Reisolates NNP cord-020235-stcrozdw 461 14 , , , cord-020235-stcrozdw 461 15 Isolated isolate VBN cord-020235-stcrozdw 461 16 after after IN cord-020235-stcrozdw 461 17 Intertypic Intertypic NNP cord-020235-stcrozdw 461 18 Superinfection Superinfection NNP cord-020235-stcrozdw 461 19 of of IN cord-020235-stcrozdw 461 20 Latent Latent NNP cord-020235-stcrozdw 461 21 Infected Infected NNP cord-020235-stcrozdw 461 22 Tupaias Tupaias NNP cord-020235-stcrozdw 461 23 DARAI DARAI NNP cord-020235-stcrozdw 461 24 , , , cord-020235-stcrozdw 461 25 G. G. NNP cord-020235-stcrozdw 461 26 and and CC cord-020235-stcrozdw 461 27 SCHOLZ SCHOLZ NNP cord-020235-stcrozdw 461 28 , , , cord-020235-stcrozdw 461 29 J. J. NNP cord-020235-stcrozdw 462 1 The the DT cord-020235-stcrozdw 462 2 susceptibility susceptibility NN cord-020235-stcrozdw 462 3 of of IN cord-020235-stcrozdw 462 4 juvenile juvenile NN cord-020235-stcrozdw 462 5 and and CC cord-020235-stcrozdw 462 6 adult adult NN cord-020235-stcrozdw 462 7 Tupaias Tupaias NNP cord-020235-stcrozdw 462 8 to to IN cord-020235-stcrozdw 462 9 Herpes Herpes NNP cord-020235-stcrozdw 462 10 simplex simplex NN cord-020235-stcrozdw 462 11 virus virus NN cord-020235-stcrozdw 462 12 type type NN cord-020235-stcrozdw 462 13 1 1 CD cord-020235-stcrozdw 462 14 and and CC cord-020235-stcrozdw 462 15 2 2 CD cord-020235-stcrozdw 462 16 had have VBD cord-020235-stcrozdw 462 17 been be VBN cord-020235-stcrozdw 462 18 reported report VBN cord-020235-stcrozdw 462 19 . . . cord-020235-stcrozdw 463 1 The the DT cord-020235-stcrozdw 463 2 intertypic intertypic JJ cord-020235-stcrozdw 463 3 recombination recombination NN cord-020235-stcrozdw 463 4 of of IN cord-020235-stcrozdw 463 5 herpes herpes NNP cord-020235-stcrozdw 463 6 simplex simplex NN cord-020235-stcrozdw 463 7 virus virus NN cord-020235-stcrozdw 463 8 using use VBG cord-020235-stcrozdw 463 9 temperature temperature NN cord-020235-stcrozdw 463 10 - - HYPH cord-020235-stcrozdw 463 11 sensitive sensitive JJ cord-020235-stcrozdw 463 12 mutants mutant NNS cord-020235-stcrozdw 463 13 of of IN cord-020235-stcrozdw 463 14 HSV HSV NNP cord-020235-stcrozdw 463 15 - - HYPH cord-020235-stcrozdw 463 16 l l NN cord-020235-stcrozdw 463 17 and and CC cord-020235-stcrozdw 463 18 2 2 CD cord-020235-stcrozdw 463 19 and and CC cord-020235-stcrozdw 463 20 superinfection superinfection NN cord-020235-stcrozdw 463 21 with with IN cord-020235-stcrozdw 463 22 wild wild JJ cord-020235-stcrozdw 463 23 - - HYPH cord-020235-stcrozdw 463 24 type type NN cord-020235-stcrozdw 463 25 HSV HSV NNP cord-020235-stcrozdw 463 26 - - HYPH cord-020235-stcrozdw 463 27 l l NN cord-020235-stcrozdw 463 28 and and CC cord-020235-stcrozdw 463 29 2 2 CD cord-020235-stcrozdw 463 30 was be VBD cord-020235-stcrozdw 463 31 studied study VBN cord-020235-stcrozdw 463 32 . . . cord-020235-stcrozdw 464 1 It -PRON- PRP cord-020235-stcrozdw 464 2 was be VBD cord-020235-stcrozdw 464 3 found find VBN cord-020235-stcrozdw 464 4 that that IN cord-020235-stcrozdw 464 5 animals animal NNS cord-020235-stcrozdw 464 6 survived survive VBD cord-020235-stcrozdw 464 7 an an DT cord-020235-stcrozdw 464 8 infection infection NN cord-020235-stcrozdw 464 9 of of IN cord-020235-stcrozdw 464 10 1 1 CD cord-020235-stcrozdw 464 11 X x CD cord-020235-stcrozdw 464 12 10 10 CD cord-020235-stcrozdw 464 13 7 7 CD cord-020235-stcrozdw 464 14 to to IN cord-020235-stcrozdw 464 15 1 1 CD cord-020235-stcrozdw 464 16 X x NN cord-020235-stcrozdw 464 17 l()8 l()8 NNP cord-020235-stcrozdw 464 18 pfu pfu NN cord-020235-stcrozdw 464 19 of of IN cord-020235-stcrozdw 464 20 rs rs NN cord-020235-stcrozdw 464 21 mutants mutant NNS cord-020235-stcrozdw 464 22 of of IN cord-020235-stcrozdw 464 23 HSV HSV NNP cord-020235-stcrozdw 464 24 - - HYPH cord-020235-stcrozdw 464 25 l l NN cord-020235-stcrozdw 464 26 and and CC cord-020235-stcrozdw 464 27 /or /or . cord-020235-stcrozdw 464 28 2 2 LS cord-020235-stcrozdw 464 29 which which WDT cord-020235-stcrozdw 464 30 were be VBD cord-020235-stcrozdw 464 31 inoculated inoculate VBN cord-020235-stcrozdw 464 32 intravenously intravenously RB cord-020235-stcrozdw 464 33 ( ( -LRB- cord-020235-stcrozdw 464 34 L0 L0 NNP cord-020235-stcrozdw 464 35 50 50 CD cord-020235-stcrozdw 464 36 for for IN cord-020235-stcrozdw 464 37 HSV HSV NNP cord-020235-stcrozdw 464 38 - - HYPH cord-020235-stcrozdw 464 39 l l NN cord-020235-stcrozdw 464 40 = = SYM cord-020235-stcrozdw 464 41 10 10 CD cord-020235-stcrozdw 464 42 - - SYM cord-020235-stcrozdw 464 43 3 3 CD cord-020235-stcrozdw 464 44 • • NNP cord-020235-stcrozdw 464 45 75 75 CD cord-020235-stcrozdw 464 46 and and CC cord-020235-stcrozdw 464 47 for for IN cord-020235-stcrozdw 464 48 HSV-2 HSV-2 NNS cord-020235-stcrozdw 464 49 = = SYM cord-020235-stcrozdw 464 50 10 10 CD cord-020235-stcrozdw 464 51 - - SYM cord-020235-stcrozdw 464 52 2 2 CD cord-020235-stcrozdw 464 53 • • CD cord-020235-stcrozdw 464 54 25 25 CD cord-020235-stcrozdw 464 55 ) ) -RRB- cord-020235-stcrozdw 464 56 . . . cord-020235-stcrozdw 465 1 The the DT cord-020235-stcrozdw 465 2 inoculated inoculate VBN cord-020235-stcrozdw 465 3 animals animal NNS cord-020235-stcrozdw 465 4 were be VBD cord-020235-stcrozdw 465 5 protected protect VBN cord-020235-stcrozdw 465 6 against against IN cord-020235-stcrozdw 465 7 a a DT cord-020235-stcrozdw 465 8 superinfection superinfection NN cord-020235-stcrozdw 465 9 of of IN cord-020235-stcrozdw 465 10 HSV HSV NNP cord-020235-stcrozdw 465 11 - - HYPH cord-020235-stcrozdw 465 12 l l NN cord-020235-stcrozdw 465 13 or or CC cord-020235-stcrozdw 465 14 2 2 CD cord-020235-stcrozdw 465 15 ( ( -LRB- cord-020235-stcrozdw 465 16 5.0 5.0 CD cord-020235-stcrozdw 465 17 X x SYM cord-020235-stcrozdw 465 18 10 10 CD cord-020235-stcrozdw 465 19 6 6 CD cord-020235-stcrozdw 465 20 pfu pfu NN cord-020235-stcrozdw 465 21 / / SYM cord-020235-stcrozdw 465 22 animals animal NNS cord-020235-stcrozdw 465 23 ) ) -RRB- cord-020235-stcrozdw 465 24 . . . cord-020235-stcrozdw 466 1 The the DT cord-020235-stcrozdw 466 2 state state NN cord-020235-stcrozdw 466 3 of of IN cord-020235-stcrozdw 466 4 viral viral JJ cord-020235-stcrozdw 466 5 latency latency NN cord-020235-stcrozdw 466 6 in in IN cord-020235-stcrozdw 466 7 surviving survive VBG cord-020235-stcrozdw 466 8 animals animal NNS cord-020235-stcrozdw 466 9 was be VBD cord-020235-stcrozdw 466 10 investigated investigate VBN cord-020235-stcrozdw 466 11 . . . cord-020235-stcrozdw 467 1 It -PRON- PRP cord-020235-stcrozdw 467 2 was be VBD cord-020235-stcrozdw 467 3 found find VBN cord-020235-stcrozdw 467 4 that that IN cord-020235-stcrozdw 467 5 infectious infectious JJ cord-020235-stcrozdw 467 6 virus virus NN cord-020235-stcrozdw 467 7 was be VBD cord-020235-stcrozdw 467 8 recovered recover VBN cord-020235-stcrozdw 467 9 from from IN cord-020235-stcrozdw 467 10 ganglia ganglion NNS cord-020235-stcrozdw 467 11 of of IN cord-020235-stcrozdw 467 12 those those DT cord-020235-stcrozdw 467 13 animals animal NNS cord-020235-stcrozdw 467 14 which which WDT cord-020235-stcrozdw 467 15 had have VBD cord-020235-stcrozdw 467 16 initially initially RB cord-020235-stcrozdw 467 17 been be VBN cord-020235-stcrozdw 467 18 infected infect VBN cord-020235-stcrozdw 467 19 with with IN cord-020235-stcrozdw 467 20 wild wild JJ cord-020235-stcrozdw 467 21 - - HYPH cord-020235-stcrozdw 467 22 type type NN cord-020235-stcrozdw 467 23 HSV HSV NNP cord-020235-stcrozdw 467 24 - - HYPH cord-020235-stcrozdw 467 25 l l NN cord-020235-stcrozdw 467 26 or or CC cord-020235-stcrozdw 467 27 2 2 CD cord-020235-stcrozdw 467 28 and and CC cord-020235-stcrozdw 467 29 /or /or . cord-020235-stcrozdw 467 30 superinfected superinfect VBN cord-020235-stcrozdw 467 31 with with IN cord-020235-stcrozdw 467 32 wild wild JJ cord-020235-stcrozdw 467 33 - - HYPH cord-020235-stcrozdw 467 34 type type NN cord-020235-stcrozdw 467 35 viruses virus NNS cord-020235-stcrozdw 467 36 . . . cord-020235-stcrozdw 468 1 In in IN cord-020235-stcrozdw 468 2 contrast contrast NN cord-020235-stcrozdw 468 3 , , , cord-020235-stcrozdw 468 4 the the DT cord-020235-stcrozdw 468 5 infectious infectious JJ cord-020235-stcrozdw 468 6 viruses virus NNS cord-020235-stcrozdw 468 7 were be VBD cord-020235-stcrozdw 468 8 recovered recover VBN cord-020235-stcrozdw 468 9 only only RB cord-020235-stcrozdw 468 10 from from IN cord-020235-stcrozdw 468 11 spleens spleen NNS cord-020235-stcrozdw 468 12 of of IN cord-020235-stcrozdw 468 13 those those DT cord-020235-stcrozdw 468 14 animals animal NNS cord-020235-stcrozdw 468 15 which which WDT cord-020235-stcrozdw 468 16 had have VBD cord-020235-stcrozdw 468 17 initially initially RB cord-020235-stcrozdw 468 18 been be VBN cord-020235-stcrozdw 468 19 infected infect VBN cord-020235-stcrozdw 468 20 with with IN cord-020235-stcrozdw 468 21 ts ts JJ cord-020235-stcrozdw 468 22 mutants mutant NNS cord-020235-stcrozdw 468 23 of of IN cord-020235-stcrozdw 468 24 HSV HSV NNP cord-020235-stcrozdw 468 25 - - HYPH cord-020235-stcrozdw 468 26 l l NN cord-020235-stcrozdw 468 27 or or CC cord-020235-stcrozdw 468 28 2 2 CD cord-020235-stcrozdw 468 29 and and CC cord-020235-stcrozdw 468 30 superinfected superinfect VBN cord-020235-stcrozdw 468 31 with with IN cord-020235-stcrozdw 469 1 wild wild JJ cord-020235-stcrozdw 469 2 - - HYPH cord-020235-stcrozdw 469 3 type type NN cord-020235-stcrozdw 469 4 HSV-2 HSV-2 NNPS cord-020235-stcrozdw 469 5 and and CC cord-020235-stcrozdw 469 6 /or /or . cord-020235-stcrozdw 469 7 1 1 CD cord-020235-stcrozdw 469 8 . . . cord-020235-stcrozdw 470 1 It -PRON- PRP cord-020235-stcrozdw 470 2 was be VBD cord-020235-stcrozdw 470 3 found find VBN cord-020235-stcrozdw 470 4 that that IN cord-020235-stcrozdw 470 5 recovered recover VBD cord-020235-stcrozdw 470 6 viruses virus NNS cord-020235-stcrozdw 470 7 from from IN cord-020235-stcrozdw 470 8 the the DT cord-020235-stcrozdw 470 9 spleen spleen NNS cord-020235-stcrozdw 470 10 of of IN cord-020235-stcrozdw 470 11 the the DT cord-020235-stcrozdw 470 12 animals animal NNS cord-020235-stcrozdw 470 13 lost lose VBD cord-020235-stcrozdw 470 14 their -PRON- PRP$ cord-020235-stcrozdw 470 15 pathogenicity pathogenicity NN cord-020235-stcrozdw 470 16 and and CC cord-020235-stcrozdw 470 17 their -PRON- PRP$ cord-020235-stcrozdw 470 18 natural natural JJ cord-020235-stcrozdw 470 19 tissue tissue NN cord-020235-stcrozdw 470 20 tropism tropism NN cord-020235-stcrozdw 470 21 . . . cord-020235-stcrozdw 471 1 Significant significant JJ cord-020235-stcrozdw 471 2 changes change NNS cord-020235-stcrozdw 471 3 in in IN cord-020235-stcrozdw 471 4 the the DT cord-020235-stcrozdw 471 5 genome genome NN cord-020235-stcrozdw 471 6 of of IN cord-020235-stcrozdw 471 7 the the DT cord-020235-stcrozdw 471 8 recovered recover VBN cord-020235-stcrozdw 471 9 viruses virus NNS cord-020235-stcrozdw 471 10 from from IN cord-020235-stcrozdw 471 11 the the DT cord-020235-stcrozdw 471 12 spleen spleen NNS cord-020235-stcrozdw 471 13 were be VBD cord-020235-stcrozdw 471 14 detected detect VBN cord-020235-stcrozdw 471 15 . . . cord-020235-stcrozdw 472 1 Recombination recombination NN cord-020235-stcrozdw 472 2 between between IN cord-020235-stcrozdw 472 3 ts ts JJ cord-020235-stcrozdw 472 4 mutants mutant NNS cord-020235-stcrozdw 472 5 of of IN cord-020235-stcrozdw 472 6 HSV HSV NNP cord-020235-stcrozdw 472 7 - - HYPH cord-020235-stcrozdw 472 8 l l NN cord-020235-stcrozdw 472 9 and and CC cord-020235-stcrozdw 472 10 2 2 CD cord-020235-stcrozdw 472 11 and and CC cord-020235-stcrozdw 472 12 challenged challenge VBD cord-020235-stcrozdw 472 13 wild wild JJ cord-020235-stcrozdw 472 14 - - HYPH cord-020235-stcrozdw 472 15 type type NN cord-020235-stcrozdw 472 16 viruses virus NNS cord-020235-stcrozdw 472 17 was be VBD cord-020235-stcrozdw 472 18 observed observe VBN cord-020235-stcrozdw 472 19 . . . cord-020235-stcrozdw 473 1 Thus thus RB cord-020235-stcrozdw 473 2 , , , cord-020235-stcrozdw 473 3 the the DT cord-020235-stcrozdw 473 4 pathogenicity pathogenicity NN cord-020235-stcrozdw 473 5 and and CC cord-020235-stcrozdw 473 6 genomic genomic JJ cord-020235-stcrozdw 473 7 properties property NNS cord-020235-stcrozdw 473 8 of of IN cord-020235-stcrozdw 473 9 recovered recover VBN cord-020235-stcrozdw 473 10 viruses virus NNS cord-020235-stcrozdw 473 11 were be VBD cord-020235-stcrozdw 473 12 altered alter VBN cord-020235-stcrozdw 473 13 . . . cord-020235-stcrozdw 474 1 This this DT cord-020235-stcrozdw 474 2 observation observation NN cord-020235-stcrozdw 474 3 is be VBZ cord-020235-stcrozdw 474 4 the the DT cord-020235-stcrozdw 474 5 first first JJ cord-020235-stcrozdw 474 6 description description NN cord-020235-stcrozdw 474 7 of of IN cord-020235-stcrozdw 474 8 generation generation NN cord-020235-stcrozdw 474 9 of of IN cord-020235-stcrozdw 474 10 inrerrypic inrerrypic JJ cord-020235-stcrozdw 474 11 recombinants recombinant NNS cord-020235-stcrozdw 474 12 of of IN cord-020235-stcrozdw 474 13 HSV HSV NNP cord-020235-stcrozdw 474 14 - - HYPH cord-020235-stcrozdw 474 15 l l NN cord-020235-stcrozdw 474 16 and and CC cord-020235-stcrozdw 474 17 2 2 CD cord-020235-stcrozdw 474 18 in in IN cord-020235-stcrozdw 474 19 in in IN cord-020235-stcrozdw 474 20 vivo vivo NN cord-020235-stcrozdw 474 21 . . . cord-020235-stcrozdw 475 1 Oiv Oiv NNP cord-020235-stcrozdw 475 2 . . . cord-020235-stcrozdw 475 3 of of IN cord-020235-stcrozdw 475 4 expo expo NNP cord-020235-stcrozdw 475 5 Virology Virology NNP cord-020235-stcrozdw 475 6 , , , cord-020235-stcrozdw 475 7 Inst Inst NNP cord-020235-stcrozdw 475 8 . . . cord-020235-stcrozdw 475 9 for for IN cord-020235-stcrozdw 475 10 Med Med NNP cord-020235-stcrozdw 475 11 . . . cord-020235-stcrozdw 475 12 Microbiology Microbiology NNP cord-020235-stcrozdw 475 13 , , , cord-020235-stcrozdw 475 14 Univ Univ NNP cord-020235-stcrozdw 475 15 . . NNP cord-020235-stcrozdw 475 16 , , , cord-020235-stcrozdw 475 17 0 0 CD cord-020235-stcrozdw 475 18 - - SYM cord-020235-stcrozdw 475 19 6500 6500 CD cord-020235-stcrozdw 475 20 Mainz Mainz NNP cord-020235-stcrozdw 475 21 The The NNP cord-020235-stcrozdw 475 22 Functions Functions NNPS cord-020235-stcrozdw 475 23 of of IN cord-020235-stcrozdw 475 24 the the DT cord-020235-stcrozdw 475 25 HSV HSV NNP cord-020235-stcrozdw 475 26 - - HYPH cord-020235-stcrozdw 475 27 Coded code VBN cord-020235-stcrozdw 475 28 dPyK dPyK NNP cord-020235-stcrozdw 475 29 - - HYPH cord-020235-stcrozdw 475 30 Complex Complex NNP cord-020235-stcrozdw 475 31 Enzyme Enzyme NNP cord-020235-stcrozdw 475 32 LABENZ LABENZ NNP cord-020235-stcrozdw 475 33 , , , cord-020235-stcrozdw 475 34 j. j. NNP cord-020235-stcrozdw 475 35 , , , cord-020235-stcrozdw 475 36 BRAUER BRAUER NNP cord-020235-stcrozdw 475 37 , , , cord-020235-stcrozdw 475 38 D. D. NNP cord-020235-stcrozdw 475 39 , , , cord-020235-stcrozdw 475 40 MOLLER MOLLER NNP cord-020235-stcrozdw 475 41 , , , cord-020235-stcrozdw 475 42 W. W. NNP cord-020235-stcrozdw 475 43 E. E. NNP cord-020235-stcrozdw 475 44 G. G. NNP cord-020235-stcrozdw 475 45 , , , cord-020235-stcrozdw 475 46 and and CC cord-020235-stcrozdw 475 47 FALKE FALKE NNP cord-020235-stcrozdw 475 48 , , , cord-020235-stcrozdw 475 49 D. D. NNP cord-020235-stcrozdw 475 50 Analysing analyse VBG cord-020235-stcrozdw 475 51 the the DT cord-020235-stcrozdw 475 52 phosphorylating phosphorylate VBG cord-020235-stcrozdw 475 53 capacity capacity NN cord-020235-stcrozdw 475 54 of of IN cord-020235-stcrozdw 475 55 the the DT cord-020235-stcrozdw 475 56 HSV HSV NNP cord-020235-stcrozdw 475 57 - - HYPH cord-020235-stcrozdw 475 58 coded code VBN cord-020235-stcrozdw 475 59 dPyK dpyk NN cord-020235-stcrozdw 475 60 of of IN cord-020235-stcrozdw 475 61 HSV HSV NNP cord-020235-stcrozdw 475 62 - - HYPH cord-020235-stcrozdw 475 63 l l NN cord-020235-stcrozdw 475 64 and and CC cord-020235-stcrozdw 475 65 2 2 CD cord-020235-stcrozdw 475 66 by by IN cord-020235-stcrozdw 475 67 glycerol glycerol NN cord-020235-stcrozdw 475 68 gradient gradient NN cord-020235-stcrozdw 475 69 centrifugation centrifugation NN cord-020235-stcrozdw 476 1 we -PRON- PRP cord-020235-stcrozdw 476 2 detected detect VBD cord-020235-stcrozdw 476 3 each each DT cord-020235-stcrozdw 476 4 three three CD cord-020235-stcrozdw 476 5 peaks peak NNS cord-020235-stcrozdw 476 6 differing differ VBG cord-020235-stcrozdw 476 7 in in IN cord-020235-stcrozdw 476 8 molecular molecular JJ cord-020235-stcrozdw 476 9 weights weight NNS cord-020235-stcrozdw 476 10 using use VBG cord-020235-stcrozdw 476 11 ATP ATP NNP cord-020235-stcrozdw 476 12 , , , cord-020235-stcrozdw 476 13 AOP AOP NNP cord-020235-stcrozdw 476 14 or or CC cord-020235-stcrozdw 476 15 AMP AMP NNP cord-020235-stcrozdw 476 16 as as IN cord-020235-stcrozdw 476 17 phosphate phosphate NN cord-020235-stcrozdw 476 18 donors donor NNS cord-020235-stcrozdw 476 19 . . . cord-020235-stcrozdw 477 1 Also also RB cord-020235-stcrozdw 477 2 by by IN cord-020235-stcrozdw 477 3 PAGE page NN cord-020235-stcrozdw 477 4 peaks peak NNS cord-020235-stcrozdw 477 5 with with IN cord-020235-stcrozdw 477 6 differ differ NNS cord-020235-stcrozdw 477 7 - - : cord-020235-stcrozdw 477 8 ing e VBG cord-020235-stcrozdw 477 9 Rj Rj NNP cord-020235-stcrozdw 477 10 - - HYPH cord-020235-stcrozdw 477 11 values value NNS cord-020235-stcrozdw 477 12 could could MD cord-020235-stcrozdw 477 13 be be VB cord-020235-stcrozdw 477 14 seen see VBN cord-020235-stcrozdw 477 15 . . . cord-020235-stcrozdw 478 1 Indeed indeed RB cord-020235-stcrozdw 478 2 , , , cord-020235-stcrozdw 478 3 32P_AMP 32P_AMP NNS cord-020235-stcrozdw 478 4 and and CC cord-020235-stcrozdw 478 5 32P_ADP 32p_adp CD cord-020235-stcrozdw 478 6 were be VBD cord-020235-stcrozdw 478 7 used use VBN cord-020235-stcrozdw 478 8 for for IN cord-020235-stcrozdw 478 9 phosphorylation phosphorylation NN cord-020235-stcrozdw 478 10 of of IN cord-020235-stcrozdw 478 11 dThd dThd NNS cord-020235-stcrozdw 478 12 . . . cord-020235-stcrozdw 479 1 The the DT cord-020235-stcrozdw 479 2 AMP AMP NNP cord-020235-stcrozdw 479 3 - - HYPH cord-020235-stcrozdw 479 4 dependent dependent JJ cord-020235-stcrozdw 479 5 activiry activiry NN cord-020235-stcrozdw 479 6 could could MD cord-020235-stcrozdw 479 7 be be VB cord-020235-stcrozdw 479 8 purified purify VBN cord-020235-stcrozdw 479 9 BOO BOO NNP cord-020235-stcrozdw 479 10 - - HYPH cord-020235-stcrozdw 479 11 fold fold NN cord-020235-stcrozdw 479 12 . . . cord-020235-stcrozdw 480 1 Two two CD cord-020235-stcrozdw 480 2 antisera antisera NN cord-020235-stcrozdw 480 3 against against IN cord-020235-stcrozdw 480 4 HSV HSV NNP cord-020235-stcrozdw 480 5 - - HYPH cord-020235-stcrozdw 480 6 coded code VBN cord-020235-stcrozdw 480 7 PdyK PdyK NNP cord-020235-stcrozdw 480 8 neutralized neutralize VBD cord-020235-stcrozdw 480 9 all all DT cord-020235-stcrozdw 480 10 three three CD cord-020235-stcrozdw 480 11 activities activity NNS cord-020235-stcrozdw 480 12 . . . cord-020235-stcrozdw 481 1 The the DT cord-020235-stcrozdw 481 2 TK TK NNP cord-020235-stcrozdw 481 3 - - HYPH cord-020235-stcrozdw 481 4 mutant mutant JJ cord-020235-stcrozdw 481 5 MDK MDK NNP cord-020235-stcrozdw 481 6 ( ( -LRB- cord-020235-stcrozdw 481 7 B2006 B2006 NNP cord-020235-stcrozdw 481 8 ) ) -RRB- cord-020235-stcrozdw 481 9 did do VBD cord-020235-stcrozdw 481 10 not not RB cord-020235-stcrozdw 481 11 induce induce VB cord-020235-stcrozdw 481 12 in'I'Kr in'I'Kr NNP cord-020235-stcrozdw 481 13 cells cell NNS cord-020235-stcrozdw 482 1 the the DT cord-020235-stcrozdw 482 2 respective respective JJ cord-020235-stcrozdw 482 3 activities activity NNS cord-020235-stcrozdw 482 4 , , , cord-020235-stcrozdw 482 5 only only RB cord-020235-stcrozdw 482 6 the the DT cord-020235-stcrozdw 482 7 3 3 CD cord-020235-stcrozdw 482 8 cellular cellular JJ cord-020235-stcrozdw 482 9 TK TK NNP cord-020235-stcrozdw 482 10 's 's POS cord-020235-stcrozdw 482 11 were be VBD cord-020235-stcrozdw 482 12 detected detect VBN cord-020235-stcrozdw 482 13 and and CC cord-020235-stcrozdw 482 14 identified identify VBN cord-020235-stcrozdw 482 15 by by IN cord-020235-stcrozdw 482 16 their -PRON- PRP$ cord-020235-stcrozdw 482 17 Rj Rj NNP cord-020235-stcrozdw 482 18 - - HYPH cord-020235-stcrozdw 482 19 values value NNS cord-020235-stcrozdw 482 20 . . . cord-020235-stcrozdw 483 1 Further further JJ cord-020235-stcrozdw 483 2 experiments experiment NNS cord-020235-stcrozdw 483 3 have have VBP cord-020235-stcrozdw 483 4 shown show VBN cord-020235-stcrozdw 483 5 that that IN cord-020235-stcrozdw 483 6 only only RB cord-020235-stcrozdw 483 7 the the DT cord-020235-stcrozdw 483 8 HSV HSV NNP cord-020235-stcrozdw 483 9 - - HYPH cord-020235-stcrozdw 483 10 l l NN cord-020235-stcrozdw 483 11 - - HYPH cord-020235-stcrozdw 483 12 dPyK dPyK NNP cord-020235-stcrozdw 483 13 has have VBZ cord-020235-stcrozdw 483 14 thymidylate thymidylate NN cord-020235-stcrozdw 483 15 kinase kinase NN cord-020235-stcrozdw 483 16 activity activity NN cord-020235-stcrozdw 483 17 , , , cord-020235-stcrozdw 483 18 but but CC cord-020235-stcrozdw 483 19 not not RB cord-020235-stcrozdw 483 20 that that DT cord-020235-stcrozdw 483 21 of of IN cord-020235-stcrozdw 483 22 HSV-2 HSV-2 NNP cord-020235-stcrozdw 483 23 . . . cord-020235-stcrozdw 484 1 The the DT cord-020235-stcrozdw 484 2 HSV HSV NNP cord-020235-stcrozdw 484 3 - - HYPH cord-020235-stcrozdw 484 4 l l NN cord-020235-stcrozdw 484 5 thymidylate thymidylate NN cord-020235-stcrozdw 484 6 kinase kinase NN cord-020235-stcrozdw 484 7 activity activity NN cord-020235-stcrozdw 484 8 could could MD cord-020235-stcrozdw 484 9 be be VB cord-020235-stcrozdw 484 10 neutralized neutralize VBN cord-020235-stcrozdw 484 11 by by IN cord-020235-stcrozdw 484 12 a a DT cord-020235-stcrozdw 484 13 TK TK NNP cord-020235-stcrozdw 484 14 - - HYPH cord-020235-stcrozdw 484 15 antiserum antiserum NN cord-020235-stcrozdw 484 16 . . . cord-020235-stcrozdw 485 1 -The -The : cord-020235-stcrozdw 485 2 pH ph NN cord-020235-stcrozdw 485 3 - - JJ cord-020235-stcrozdw 485 4 optimum optimum JJ cord-020235-stcrozdw 485 5 , , , cord-020235-stcrozdw 485 6 sensitivity sensitivity NN cord-020235-stcrozdw 485 7 to to IN cord-020235-stcrozdw 485 8 Mg Mg NNP cord-020235-stcrozdw 485 9 ' ' POS cord-020235-stcrozdw 485 10 " " '' cord-020235-stcrozdw 485 11 , , , cord-020235-stcrozdw 485 12 Fe Fe NNP cord-020235-stcrozdw 485 13 ' ' '' cord-020235-stcrozdw 485 14 " " '' cord-020235-stcrozdw 485 15 , , , cord-020235-stcrozdw 485 16 Zn Zn NNP cord-020235-stcrozdw 485 17 ' ' '' cord-020235-stcrozdw 485 18 " " '' cord-020235-stcrozdw 485 19 , , , cord-020235-stcrozdw 485 20 Co Co NNP cord-020235-stcrozdw 485 21 " " '' cord-020235-stcrozdw 485 22 and and CC cord-020235-stcrozdw 485 23 Mri Mri NNP cord-020235-stcrozdw 485 24 ' ' POS cord-020235-stcrozdw 485 25 " " `` cord-020235-stcrozdw 485 26 ions ion NNS cord-020235-stcrozdw 485 27 differed differ VBD cord-020235-stcrozdw 485 28 . . . cord-020235-stcrozdw 486 1 The the DT cord-020235-stcrozdw 486 2 susceptibility susceptibility NN cord-020235-stcrozdw 486 3 to to IN cord-020235-stcrozdw 486 4 thiol thiol NN cord-020235-stcrozdw 486 5 reagents reagent NNS cord-020235-stcrozdw 486 6 was be VBD cord-020235-stcrozdw 486 7 different different JJ cord-020235-stcrozdw 486 8 , , , cord-020235-stcrozdw 486 9 the the DT cord-020235-stcrozdw 486 10 AMP amp NN cord-020235-stcrozdw 486 11 - - HYPH cord-020235-stcrozdw 486 12 dependent dependent JJ cord-020235-stcrozdw 486 13 activity activity NN cord-020235-stcrozdw 486 14 proved prove VBD cord-020235-stcrozdw 486 15 to to TO cord-020235-stcrozdw 486 16 be be VB cord-020235-stcrozdw 486 17 susceptible susceptible JJ cord-020235-stcrozdw 486 18 to to IN cord-020235-stcrozdw 486 19 phenanthroline phenanthroline NN cord-020235-stcrozdw 486 20 . . . cord-020235-stcrozdw 487 1 Also also RB cord-020235-stcrozdw 487 2 the the DT cord-020235-stcrozdw 487 3 K K NNP cord-020235-stcrozdw 487 4 m m NNP cord-020235-stcrozdw 487 5 and and CC cord-020235-stcrozdw 487 6 Vrnax Vrnax NNP cord-020235-stcrozdw 487 7 - - HYPH cord-020235-stcrozdw 487 8 values value NNS cord-020235-stcrozdw 487 9 were be VBD cord-020235-stcrozdw 487 10 detected detect VBN cord-020235-stcrozdw 487 11 . . . cord-020235-stcrozdw 488 1 A a DT cord-020235-stcrozdw 488 2 diagram diagram NN cord-020235-stcrozdw 488 3 summarizes summarize VBZ cord-020235-stcrozdw 488 4 the the DT cord-020235-stcrozdw 488 5 biochemical biochemical JJ cord-020235-stcrozdw 488 6 function function NN cord-020235-stcrozdw 488 7 of of IN cord-020235-stcrozdw 488 8 the the DT cord-020235-stcrozdw 488 9 HSV HSV NNP cord-020235-stcrozdw 488 10 - - HYPH cord-020235-stcrozdw 488 11 coded code VBN cord-020235-stcrozdw 488 12 dPyK dpyk NN cord-020235-stcrozdw 488 13 - - NN cord-020235-stcrozdw 488 14 complex complex JJ cord-020235-stcrozdw 488 15 . . . cord-020235-stcrozdw 489 1 Finally finally RB cord-020235-stcrozdw 489 2 there there EX cord-020235-stcrozdw 489 3 is be VBZ cord-020235-stcrozdw 489 4 some some DT cord-020235-stcrozdw 489 5 indication indication NN cord-020235-stcrozdw 489 6 that that IN cord-020235-stcrozdw 489 7 the the DT cord-020235-stcrozdw 489 8 enzyme enzyme NN cord-020235-stcrozdw 489 9 phosphorylates phosphorylate VBZ cord-020235-stcrozdw 489 10 Ado Ado NNP cord-020235-stcrozdw 489 11 by by IN cord-020235-stcrozdw 489 12 using use VBG cord-020235-stcrozdw 489 13 dTMP dTMP NNP cord-020235-stcrozdw 489 14 or or CC cord-020235-stcrozdw 489 15 ATP ATP NNP cord-020235-stcrozdw 489 16 as as IN cord-020235-stcrozdw 489 17 a a DT cord-020235-stcrozdw 489 18 phosphate phosphate NN cord-020235-stcrozdw 489 19 donor donor NN cord-020235-stcrozdw 489 20 . . . cord-020235-stcrozdw 490 1 The the DT cord-020235-stcrozdw 490 2 importance importance NN cord-020235-stcrozdw 490 3 of of IN cord-020235-stcrozdw 490 4 the the DT cord-020235-stcrozdw 490 5 enzyme enzyme NN cord-020235-stcrozdw 490 6 complex complex NN cord-020235-stcrozdw 490 7 in in IN cord-020235-stcrozdw 490 8 HSV HSV NNP cord-020235-stcrozdw 490 9 - - HYPH cord-020235-stcrozdw 490 10 infected infect VBN cord-020235-stcrozdw 490 11 cells cell NNS cord-020235-stcrozdw 490 12 is be VBZ cord-020235-stcrozdw 490 13 discussed discuss VBN cord-020235-stcrozdw 490 14 . . . cord-020235-stcrozdw 491 1 DKFZ DKFZ NNP cord-020235-stcrozdw 491 2 , , , cord-020235-stcrozdw 491 3 Inst Inst NNP cord-020235-stcrozdw 491 4 . . . cord-020235-stcrozdw 492 1 f. f. NNP cord-020235-stcrozdw 492 2 Virusforschung Virusforschung NNP cord-020235-stcrozdw 492 3 , , , cord-020235-stcrozdw 492 4 1 1 CD cord-020235-stcrozdw 492 5 m m NNP cord-020235-stcrozdw 492 6 Neuenheimer Neuenheimer NNP cord-020235-stcrozdw 492 7 Feld Feld NNP cord-020235-stcrozdw 492 8 280 280 CD cord-020235-stcrozdw 492 9 , , , cord-020235-stcrozdw 492 10 Deletion deletion NN cord-020235-stcrozdw 492 11 of of IN cord-020235-stcrozdw 492 12 N n CD cord-020235-stcrozdw 492 13 uc1eotide uc1eotide NN cord-020235-stcrozdw 492 14 - - : cord-020235-stcrozdw 492 15 Sequences sequence NNS cord-020235-stcrozdw 492 16 in in IN cord-020235-stcrozdw 492 17 Cloned clone VBN cord-020235-stcrozdw 492 18 HSV-1 hsv-1 NN cord-020235-stcrozdw 492 19 Fragments fragment NNS cord-020235-stcrozdw 492 20 during during IN cord-020235-stcrozdw 492 21 Propagation Propagation NNP cord-020235-stcrozdw 492 22 in in IN cord-020235-stcrozdw 492 23 the the DT cord-020235-stcrozdw 492 24 rec rec NN cord-020235-stcrozdw 492 25 A A NNP cord-020235-stcrozdw 492 26 E. E. NNP cord-020235-stcrozdw 492 27 coli coli NNS cord-020235-stcrozdw 492 28 , , , cord-020235-stcrozdw 492 29 HB HB NNP cord-020235-stcrozdw 492 30 101 101 CD cord-020235-stcrozdw 492 31 GRAY GRAY NNP cord-020235-stcrozdw 492 32 , , , cord-020235-stcrozdw 492 33 C. C. NNP cord-020235-stcrozdw 492 34 P. P. NNP cord-020235-stcrozdw 492 35 , , , cord-020235-stcrozdw 492 36 JELLINGHAUS JELLINGHAUS NNP cord-020235-stcrozdw 492 37 , , , cord-020235-stcrozdw 492 38 U. U. NNP cord-020235-stcrozdw 492 39 , , , cord-020235-stcrozdw 492 40 and and CC cord-020235-stcrozdw 492 41 KAERNER KAERNER NNP cord-020235-stcrozdw 492 42 , , , cord-020235-stcrozdw 492 43 H. H. NNP cord-020235-stcrozdw 492 44 C. C. NNP cord-020235-stcrozdw 492 45 Passage Passage NNP cord-020235-stcrozdw 492 46 of of IN cord-020235-stcrozdw 492 47 HSV HSV NNP cord-020235-stcrozdw 492 48 at at IN cord-020235-stcrozdw 492 49 high high JJ cord-020235-stcrozdw 492 50 MOl MOl NNP cord-020235-stcrozdw 492 51 results result NNS cord-020235-stcrozdw 492 52 in in IN cord-020235-stcrozdw 492 53 the the DT cord-020235-stcrozdw 492 54 generation generation NN cord-020235-stcrozdw 492 55 of of IN cord-020235-stcrozdw 492 56 defective defective JJ cord-020235-stcrozdw 492 57 genomes genome NNS cord-020235-stcrozdw 492 58 which which WDT cord-020235-stcrozdw 492 59 are be VBP cord-020235-stcrozdw 492 60 of of IN cord-020235-stcrozdw 492 61 full full JJ cord-020235-stcrozdw 492 62 length length NN cord-020235-stcrozdw 492 63 , , , cord-020235-stcrozdw 492 64 consisting consist VBG cord-020235-stcrozdw 492 65 of of IN cord-020235-stcrozdw 492 66 a a DT cord-020235-stcrozdw 492 67 relatively relatively RB cord-020235-stcrozdw 492 68 short short JJ cord-020235-stcrozdw 492 69 region region NN cord-020235-stcrozdw 492 70 of of IN cord-020235-stcrozdw 492 71 the the DT cord-020235-stcrozdw 492 72 wild wild JJ cord-020235-stcrozdw 492 73 type type NN cord-020235-stcrozdw 492 74 genome genome NN cord-020235-stcrozdw 492 75 that that WDT cord-020235-stcrozdw 492 76 is be VBZ cord-020235-stcrozdw 492 77 repeated repeat VBN cord-020235-stcrozdw 492 78 . . . cord-020235-stcrozdw 493 1 They -PRON- PRP cord-020235-stcrozdw 493 2 are be VBP cord-020235-stcrozdw 493 3 packaged package VBN cord-020235-stcrozdw 493 4 into into IN cord-020235-stcrozdw 493 5 mature mature JJ cord-020235-stcrozdw 493 6 virus virus NN cord-020235-stcrozdw 493 7 particles particle NNS cord-020235-stcrozdw 493 8 and and CC cord-020235-stcrozdw 493 9 thus thus RB cord-020235-stcrozdw 493 10 leave leave VB cord-020235-stcrozdw 493 11 the the DT cord-020235-stcrozdw 493 12 cell cell NN cord-020235-stcrozdw 493 13 in in IN cord-020235-stcrozdw 493 14 a a DT cord-020235-stcrozdw 493 15 state state NN cord-020235-stcrozdw 493 16 that that WDT cord-020235-stcrozdw 493 17 is be VBZ cord-020235-stcrozdw 493 18 capable capable JJ cord-020235-stcrozdw 493 19 of of IN cord-020235-stcrozdw 493 20 entering enter VBG cord-020235-stcrozdw 493 21 a a DT cord-020235-stcrozdw 493 22 new new JJ cord-020235-stcrozdw 493 23 host host NN cord-020235-stcrozdw 493 24 . . . cord-020235-stcrozdw 494 1 Such such JJ cord-020235-stcrozdw 494 2 defective defective JJ cord-020235-stcrozdw 494 3 molecules molecule NNS cord-020235-stcrozdw 494 4 are be VBP cord-020235-stcrozdw 494 5 of of IN cord-020235-stcrozdw 494 6 interest interest NN cord-020235-stcrozdw 494 7 as as IN cord-020235-stcrozdw 494 8 they -PRON- PRP cord-020235-stcrozdw 494 9 represent represent VBP cord-020235-stcrozdw 494 10 a a DT cord-020235-stcrozdw 494 11 simpler simple JJR cord-020235-stcrozdw 494 12 model model NN cord-020235-stcrozdw 494 13 in in IN cord-020235-stcrozdw 494 14 which which WDT cord-020235-stcrozdw 494 15 to to TO cord-020235-stcrozdw 494 16 study study VB cord-020235-stcrozdw 494 17 replication replication NN cord-020235-stcrozdw 494 18 , , , cord-020235-stcrozdw 494 19 recombination recombination NN cord-020235-stcrozdw 494 20 and and CC cord-020235-stcrozdw 494 21 packaging packaging NN cord-020235-stcrozdw 494 22 of of IN cord-020235-stcrozdw 494 23 HSV HSV NNP cord-020235-stcrozdw 494 24 . . . cord-020235-stcrozdw 495 1 -Such -Such . cord-020235-stcrozdw 496 1 a a DT cord-020235-stcrozdw 496 2 defective defective JJ cord-020235-stcrozdw 496 3 molecule molecule NN cord-020235-stcrozdw 496 4 arising arise VBG cord-020235-stcrozdw 496 5 from from IN cord-020235-stcrozdw 496 6 the the DT cord-020235-stcrozdw 496 7 serial serial JJ cord-020235-stcrozdw 496 8 passage passage NN cord-020235-stcrozdw 496 9 of of IN cord-020235-stcrozdw 496 10 HSVtype HSVtype NNP cord-020235-stcrozdw 496 11 l l NNP cord-020235-stcrozdw 496 12 - - HYPH cord-020235-stcrozdw 496 13 ANG ANG NNP cord-020235-stcrozdw 496 14 has have VBZ cord-020235-stcrozdw 496 15 been be VBN cord-020235-stcrozdw 496 16 mapped map VBN cord-020235-stcrozdw 496 17 , , , cord-020235-stcrozdw 496 18 and and CC cord-020235-stcrozdw 496 19 restriction restriction NN cord-020235-stcrozdw 496 20 fragments fragment NNS cord-020235-stcrozdw 496 21 have have VBP cord-020235-stcrozdw 496 22 been be VBN cord-020235-stcrozdw 496 23 cloned clone VBN cord-020235-stcrozdw 496 24 into into IN cord-020235-stcrozdw 496 25 pBR pbr RB cord-020235-stcrozdw 496 26 322 322 CD cord-020235-stcrozdw 496 27 using use VBG cord-020235-stcrozdw 496 28 the the DT cord-020235-stcrozdw 496 29 rec rec NNP cord-020235-stcrozdw 496 30 A A NNP cord-020235-stcrozdw 496 31 - - HYPH cord-020235-stcrozdw 496 32 E.coH E.coH NNP cord-020235-stcrozdw 496 33 , , , cord-020235-stcrozdw 496 34 HB HB NNP cord-020235-stcrozdw 496 35 101 101 CD cord-020235-stcrozdw 496 36 , , , cord-020235-stcrozdw 496 37 as as IN cord-020235-stcrozdw 496 38 host host NN cord-020235-stcrozdw 496 39 . . . cord-020235-stcrozdw 497 1 -All -All : cord-020235-stcrozdw 498 1 the the DT cord-020235-stcrozdw 498 2 resulting result VBG cord-020235-stcrozdw 498 3 clones clone NNS cord-020235-stcrozdw 498 4 were be VBD cord-020235-stcrozdw 498 5 found find VBN cord-020235-stcrozdw 498 6 to to TO cord-020235-stcrozdw 498 7 be be VB cord-020235-stcrozdw 498 8 unstable unstable JJ cord-020235-stcrozdw 498 9 and and CC cord-020235-stcrozdw 498 10 to to TO cord-020235-stcrozdw 498 11 contain contain VB cord-020235-stcrozdw 498 12 deletions deletion NNS cord-020235-stcrozdw 498 13 , , , cord-020235-stcrozdw 498 14 one one CD cord-020235-stcrozdw 498 15 of of IN cord-020235-stcrozdw 498 16 which which WDT cord-020235-stcrozdw 498 17 has have VBZ cord-020235-stcrozdw 498 18 been be VBN cord-020235-stcrozdw 498 19 characterised characterise VBN cord-020235-stcrozdw 498 20 in in IN cord-020235-stcrozdw 498 21 more more JJR cord-020235-stcrozdw 498 22 detail detail NN cord-020235-stcrozdw 498 23 . . . cord-020235-stcrozdw 499 1 The the DT cord-020235-stcrozdw 499 2 isolation isolation NN cord-020235-stcrozdw 499 3 and and CC cord-020235-stcrozdw 499 4 characterization characterization NN cord-020235-stcrozdw 499 5 of of IN cord-020235-stcrozdw 499 6 Tupaia Tupaia NNP cord-020235-stcrozdw 499 7 Herpesviruses Herpesviruses NNP cord-020235-stcrozdw 499 8 ( ( -LRB- cord-020235-stcrozdw 499 9 THY THY NNP cord-020235-stcrozdw 499 10 1 1 CD cord-020235-stcrozdw 499 11 to to IN cord-020235-stcrozdw 499 12 4 4 CD cord-020235-stcrozdw 499 13 ) ) -RRB- cord-020235-stcrozdw 499 14 has have VBZ cord-020235-stcrozdw 499 15 been be VBN cord-020235-stcrozdw 499 16 reported report VBN cord-020235-stcrozdw 499 17 . . . cord-020235-stcrozdw 500 1 The the DT cord-020235-stcrozdw 500 2 analysis analysis NN cord-020235-stcrozdw 500 3 of of IN cord-020235-stcrozdw 500 4 DNA dna NN cord-020235-stcrozdw 500 5 of of IN cord-020235-stcrozdw 500 6 these these DT cord-020235-stcrozdw 500 7 viruses virus NNS cord-020235-stcrozdw 500 8 showed show VBD cord-020235-stcrozdw 500 9 the the DT cord-020235-stcrozdw 500 10 absence absence NN cord-020235-stcrozdw 500 11 of of IN cord-020235-stcrozdw 500 12 submolar submolar JJ cord-020235-stcrozdw 500 13 DNA dna NN cord-020235-stcrozdw 500 14 fragments fragment NNS cord-020235-stcrozdw 500 15 , , , cord-020235-stcrozdw 500 16 when when WRB cord-020235-stcrozdw 500 17 the the DT cord-020235-stcrozdw 500 18 DNA dna NN cord-020235-stcrozdw 500 19 was be VBD cord-020235-stcrozdw 500 20 cleaved cleave VBN cord-020235-stcrozdw 500 21 with with IN cord-020235-stcrozdw 500 22 different different JJ cord-020235-stcrozdw 500 23 restriction restriction NN cord-020235-stcrozdw 500 24 enzymes enzyme NNS cord-020235-stcrozdw 500 25 , , , cord-020235-stcrozdw 500 26 as as RB cord-020235-stcrozdw 500 27 well well RB cord-020235-stcrozdw 500 28 as as IN cord-020235-stcrozdw 500 29 of of IN cord-020235-stcrozdw 500 30 a a DT cord-020235-stcrozdw 500 31 stem stem NN cord-020235-stcrozdw 500 32 loop loop NN cord-020235-stcrozdw 500 33 structure structure NN cord-020235-stcrozdw 500 34 , , , cord-020235-stcrozdw 500 35 when when WRB cord-020235-stcrozdw 500 36 analysed analyse VBN cord-020235-stcrozdw 500 37 by by IN cord-020235-stcrozdw 500 38 electron electron NN cord-020235-stcrozdw 500 39 microscopy microscopy NN cord-020235-stcrozdw 500 40 . . . cord-020235-stcrozdw 501 1 With with IN cord-020235-stcrozdw 501 2 respect respect NN cord-020235-stcrozdw 501 3 to to IN cord-020235-stcrozdw 501 4 this this DT cord-020235-stcrozdw 501 5 genomic genomic JJ cord-020235-stcrozdw 501 6 structure structure NN cord-020235-stcrozdw 502 1 it -PRON- PRP cord-020235-stcrozdw 502 2 was be VBD cord-020235-stcrozdw 502 3 of of IN cord-020235-stcrozdw 502 4 interest interest NN cord-020235-stcrozdw 502 5 to to TO cord-020235-stcrozdw 502 6 study study VB cord-020235-stcrozdw 502 7 he -PRON- PRP cord-020235-stcrozdw 502 8 recombination recombination NN cord-020235-stcrozdw 502 9 events event NNS cord-020235-stcrozdw 502 10 between between IN cord-020235-stcrozdw 502 11 THV thv NN cord-020235-stcrozdw 502 12 1 1 CD cord-020235-stcrozdw 502 13 to to IN cord-020235-stcrozdw 502 14 4 4 CD cord-020235-stcrozdw 502 15 . . . cord-020235-stcrozdw 503 1 Recombinants recombinant NNS cord-020235-stcrozdw 503 2 were be VBD cord-020235-stcrozdw 503 3 generated generate VBN cord-020235-stcrozdw 503 4 between between IN cord-020235-stcrozdw 503 5 these these DT cord-020235-stcrozdw 503 6 viruses virus NNS cord-020235-stcrozdw 503 7 using use VBG cord-020235-stcrozdw 503 8 a a DT cord-020235-stcrozdw 503 9 co co NN cord-020235-stcrozdw 503 10 - - NN cord-020235-stcrozdw 503 11 infection infection JJ cord-020235-stcrozdw 503 12 technique technique NN cord-020235-stcrozdw 503 13 in in IN cord-020235-stcrozdw 503 14 vitro vitro FW cord-020235-stcrozdw 503 15 on on IN cord-020235-stcrozdw 503 16 Tupaia Tupaia NNP cord-020235-stcrozdw 503 17 fibroblasts fibroblast NNS cord-020235-stcrozdw 503 18 . . . cord-020235-stcrozdw 504 1 Recombinants recombinant NNS cord-020235-stcrozdw 504 2 were be VBD cord-020235-stcrozdw 504 3 selected select VBN cord-020235-stcrozdw 504 4 after after IN cord-020235-stcrozdw 504 5 the the DT cord-020235-stcrozdw 504 6 stocks stock NNS cord-020235-stcrozdw 504 7 of of IN cord-020235-stcrozdw 504 8 new new JJ cord-020235-stcrozdw 504 9 progency progency NN cord-020235-stcrozdw 504 10 virus virus NN cord-020235-stcrozdw 504 11 were be VBD cord-020235-stcrozdw 504 12 treated treat VBN cord-020235-stcrozdw 504 13 with with IN cord-020235-stcrozdw 504 14 specific specific JJ cord-020235-stcrozdw 504 15 antiserum antiserum NN cord-020235-stcrozdw 504 16 against against IN cord-020235-stcrozdw 504 17 each each DT cord-020235-stcrozdw 504 18 parental parental JJ cord-020235-stcrozdw 504 19 virus virus NN cord-020235-stcrozdw 504 20 . . . cord-020235-stcrozdw 505 1 Different different JJ cord-020235-stcrozdw 505 2 recombinants recombinant NNS cord-020235-stcrozdw 505 3 were be VBD cord-020235-stcrozdw 505 4 isolated isolate VBN cord-020235-stcrozdw 505 5 , , , cord-020235-stcrozdw 505 6 plaque plaque NN cord-020235-stcrozdw 505 7 - - HYPH cord-020235-stcrozdw 505 8 purified purify VBN cord-020235-stcrozdw 505 9 and and CC cord-020235-stcrozdw 505 10 characterized characterize VBN cord-020235-stcrozdw 505 11 . . . cord-020235-stcrozdw 506 1 Results result NNS cord-020235-stcrozdw 506 2 for for IN cord-020235-stcrozdw 506 3 one one CD cord-020235-stcrozdw 506 4 recombinant recombinant JJ cord-020235-stcrozdw 506 5 THV THV NNP cord-020235-stcrozdw 506 6 - - HYPH cord-020235-stcrozdw 506 7 R-26 R-26 NNP cord-020235-stcrozdw 506 8 between between IN cord-020235-stcrozdw 506 9 THV-2 THV-2 NNP cord-020235-stcrozdw 506 10 and and CC cord-020235-stcrozdw 506 11 3 3 CD cord-020235-stcrozdw 506 12 were be VBD cord-020235-stcrozdw 506 13 as as IN cord-020235-stcrozdw 506 14 follows follow VBZ cord-020235-stcrozdw 506 15 : : : cord-020235-stcrozdw 507 1 ( ( -LRB- cord-020235-stcrozdw 507 2 i i NN cord-020235-stcrozdw 507 3 ) ) -RRB- cord-020235-stcrozdw 508 1 The the DT cord-020235-stcrozdw 508 2 in in FW cord-020235-stcrozdw 508 3 vitro vitro FW cord-020235-stcrozdw 508 4 host host NN cord-020235-stcrozdw 508 5 range range NN cord-020235-stcrozdw 508 6 and and CC cord-020235-stcrozdw 508 7 the the DT cord-020235-stcrozdw 508 8 in in IN cord-020235-stcrozdw 508 9 vivo vivo NN cord-020235-stcrozdw 508 10 pathogenicity pathogenicity NN cord-020235-stcrozdw 508 11 in in IN cord-020235-stcrozdw 508 12 juvenile juvenile JJ cord-020235-stcrozdw 508 13 Tupaia Tupaia NNP cord-020235-stcrozdw 508 14 was be VBD cord-020235-stcrozdw 508 15 altered alter VBN cord-020235-stcrozdw 508 16 compared compare VBN cord-020235-stcrozdw 508 17 to to IN cord-020235-stcrozdw 508 18 parental parental JJ cord-020235-stcrozdw 508 19 viruses virus NNS cord-020235-stcrozdw 508 20 . . . cord-020235-stcrozdw 509 1 Phosphorylation phosphorylation NN cord-020235-stcrozdw 509 2 of of IN cord-020235-stcrozdw 509 3 proteins protein NNS cord-020235-stcrozdw 509 4 is be VBZ cord-020235-stcrozdw 509 5 a a DT cord-020235-stcrozdw 509 6 posttranslational posttranslational JJ cord-020235-stcrozdw 509 7 modification modification NN cord-020235-stcrozdw 509 8 which which WDT cord-020235-stcrozdw 509 9 is be VBZ cord-020235-stcrozdw 509 10 regulatory regulatory JJ cord-020235-stcrozdw 509 11 for for IN cord-020235-stcrozdw 509 12 the the DT cord-020235-stcrozdw 509 13 activity activity NN cord-020235-stcrozdw 509 14 of of IN cord-020235-stcrozdw 509 15 several several JJ cord-020235-stcrozdw 509 16 enzymes enzyme NNS cord-020235-stcrozdw 509 17 . . . cord-020235-stcrozdw 510 1 Most Most JJS cord-020235-stcrozdw 510 2 animal animal NN cord-020235-stcrozdw 510 3 viruses virus NNS cord-020235-stcrozdw 510 4 code code NN cord-020235-stcrozdw 510 5 for for IN cord-020235-stcrozdw 510 6 phosphoproreins phosphoprorein NNS cord-020235-stcrozdw 510 7 and and CC cord-020235-stcrozdw 510 8 the the DT cord-020235-stcrozdw 510 9 degree degree NN cord-020235-stcrozdw 510 10 of of IN cord-020235-stcrozdw 510 11 their -PRON- PRP$ cord-020235-stcrozdw 510 12 phosphorylation phosphorylation NN cord-020235-stcrozdw 510 13 is be VBZ cord-020235-stcrozdw 510 14 thought think VBN cord-020235-stcrozdw 510 15 to to TO cord-020235-stcrozdw 510 16 be be VB cord-020235-stcrozdw 510 17 a a DT cord-020235-stcrozdw 510 18 controlling control VBG cord-020235-stcrozdw 510 19 factor factor NN cord-020235-stcrozdw 510 20 during during IN cord-020235-stcrozdw 510 21 viral viral JJ cord-020235-stcrozdw 510 22 macromolecular macromolecular JJ cord-020235-stcrozdw 510 23 synthesis synthesis NN cord-020235-stcrozdw 510 24 . . . cord-020235-stcrozdw 511 1 Recent recent JJ cord-020235-stcrozdw 511 2 studies study NNS cord-020235-stcrozdw 511 3 on on IN cord-020235-stcrozdw 511 4 protein protein NN cord-020235-stcrozdw 511 5 kinases kinase NNS cord-020235-stcrozdw 511 6 from from IN cord-020235-stcrozdw 511 7 a a DT cord-020235-stcrozdw 511 8 number number NN cord-020235-stcrozdw 511 9 of of IN cord-020235-stcrozdw 511 10 tumor tumor NN cord-020235-stcrozdw 511 11 viruses virus NNS cord-020235-stcrozdw 511 12 have have VBP cord-020235-stcrozdw 511 13 raised raise VBN cord-020235-stcrozdw 511 14 the the DT cord-020235-stcrozdw 511 15 possibility possibility NN cord-020235-stcrozdw 511 16 that that IN cord-020235-stcrozdw 511 17 the the DT cord-020235-stcrozdw 511 18 phosphorylation phosphorylation NN cord-020235-stcrozdw 511 19 of of IN cord-020235-stcrozdw 511 20 cell cell NN cord-020235-stcrozdw 511 21 proteins protein NNS cord-020235-stcrozdw 511 22 is be VBZ cord-020235-stcrozdw 511 23 involved involve VBN cord-020235-stcrozdw 511 24 in in IN cord-020235-stcrozdw 511 25 the the DT cord-020235-stcrozdw 511 26 processes process NNS cord-020235-stcrozdw 511 27 leading lead VBG cord-020235-stcrozdw 511 28 to to IN cord-020235-stcrozdw 511 29 cell cell NN cord-020235-stcrozdw 511 30 transformation transformation NN cord-020235-stcrozdw 511 31 . . . cord-020235-stcrozdw 512 1 -Incubation -incubation NN cord-020235-stcrozdw 512 2 of of IN cord-020235-stcrozdw 513 1 purified purify VBN cord-020235-stcrozdw 513 2 tree tree NN cord-020235-stcrozdw 513 3 shrew shrew NN cord-020235-stcrozdw 513 4 ( ( -LRB- cord-020235-stcrozdw 513 5 Tupaia Tupaia NNP cord-020235-stcrozdw 513 6 ) ) -RRB- cord-020235-stcrozdw 513 7 herpesvirus herpesvirus NN cord-020235-stcrozdw 513 8 ( ( -LRB- cord-020235-stcrozdw 513 9 THV thv NN cord-020235-stcrozdw 513 10 ) ) -RRB- cord-020235-stcrozdw 513 11 particles particle NNS cord-020235-stcrozdw 513 12 with with IN cord-020235-stcrozdw 513 13 y.32p y.32p NNP cord-020235-stcrozdw 513 14 ATP ATP NNP cord-020235-stcrozdw 513 15 resulted result VBD cord-020235-stcrozdw 513 16 in in IN cord-020235-stcrozdw 513 17 the the DT cord-020235-stcrozdw 513 18 incorporation incorporation NN cord-020235-stcrozdw 513 19 of of IN cord-020235-stcrozdw 513 20 32p 32p CD cord-020235-stcrozdw 513 21 labelled label VBN cord-020235-stcrozdw 513 22 phosphate phosphate NN cord-020235-stcrozdw 513 23 into into IN cord-020235-stcrozdw 513 24 proteins protein NNS cord-020235-stcrozdw 513 25 . . . cord-020235-stcrozdw 514 1 A a DT cord-020235-stcrozdw 514 2 nonionic nonionic JJ cord-020235-stcrozdw 514 3 detergent detergent NN cord-020235-stcrozdw 514 4 such such JJ cord-020235-stcrozdw 514 5 as as IN cord-020235-stcrozdw 514 6 NP-40 NP-40 NNP cord-020235-stcrozdw 514 7 was be VBD cord-020235-stcrozdw 514 8 necessary necessary JJ cord-020235-stcrozdw 514 9 for for IN cord-020235-stcrozdw 514 10 the the DT cord-020235-stcrozdw 514 11 detection detection NN cord-020235-stcrozdw 514 12 of of IN cord-020235-stcrozdw 514 13 protein protein NN cord-020235-stcrozdw 514 14 kinase kinase NN cord-020235-stcrozdw 514 15 activity activity NN cord-020235-stcrozdw 514 16 . . . cord-020235-stcrozdw 515 1 The the DT cord-020235-stcrozdw 515 2 incorporation incorporation NN cord-020235-stcrozdw 515 3 of of IN cord-020235-stcrozdw 515 4 32phosphate 32phosphate CD cord-020235-stcrozdw 515 5 was be VBD cord-020235-stcrozdw 515 6 proportional proportional JJ cord-020235-stcrozdw 515 7 to to IN cord-020235-stcrozdw 515 8 the the DT cord-020235-stcrozdw 515 9 quantity quantity NN cord-020235-stcrozdw 515 10 of of IN cord-020235-stcrozdw 515 11 TH TH NNP cord-020235-stcrozdw 515 12 viral viral JJ cord-020235-stcrozdw 515 13 proteins protein NNS cord-020235-stcrozdw 515 14 , , , cord-020235-stcrozdw 515 15 indicating indicate VBG cord-020235-stcrozdw 515 16 that that IN cord-020235-stcrozdw 515 17 the the DT cord-020235-stcrozdw 515 18 viral viral JJ cord-020235-stcrozdw 515 19 proteins protein NNS cord-020235-stcrozdw 515 20 can can MD cord-020235-stcrozdw 515 21 serve serve VB cord-020235-stcrozdw 515 22 as as IN cord-020235-stcrozdw 515 23 substrates substrate NNS cord-020235-stcrozdw 515 24 for for IN cord-020235-stcrozdw 515 25 the the DT cord-020235-stcrozdw 515 26 viral viral JJ cord-020235-stcrozdw 515 27 enzyme enzyme NN cord-020235-stcrozdw 515 28 . . . cord-020235-stcrozdw 516 1 a a DT cord-020235-stcrozdw 516 2 _ _ NNP cord-020235-stcrozdw 516 3 32p 32p CD cord-020235-stcrozdw 516 4 dATP datp NN cord-020235-stcrozdw 516 5 or or CC cord-020235-stcrozdw 516 6 a a DT cord-020235-stcrozdw 516 7 _ _ NN cord-020235-stcrozdw 516 8 32P 32p CD cord-020235-stcrozdw 516 9 ATP ATP NNP cord-020235-stcrozdw 516 10 did do VBD cord-020235-stcrozdw 516 11 not not RB cord-020235-stcrozdw 516 12 function function VB cord-020235-stcrozdw 516 13 as as IN cord-020235-stcrozdw 516 14 phosphate phosphate NN cord-020235-stcrozdw 516 15 donors donor NNS cord-020235-stcrozdw 516 16 . . . cord-020235-stcrozdw 517 1 A a DT cord-020235-stcrozdw 517 2 divalent divalent JJ cord-020235-stcrozdw 517 3 cation cation NN cord-020235-stcrozdw 517 4 such such JJ cord-020235-stcrozdw 517 5 as as IN cord-020235-stcrozdw 517 6 Mg2 mg2 CD cord-020235-stcrozdw 517 7 + + CC cord-020235-stcrozdw 517 8 or or CC cord-020235-stcrozdw 517 9 Mn Mn NNP cord-020235-stcrozdw 517 10 ' ' '' cord-020235-stcrozdw 517 11 " " `` cord-020235-stcrozdw 517 12 is be VBZ cord-020235-stcrozdw 517 13 essential essential JJ cord-020235-stcrozdw 517 14 for for IN cord-020235-stcrozdw 517 15 the the DT cord-020235-stcrozdw 517 16 enzymatic enzymatic JJ cord-020235-stcrozdw 517 17 activity activity NN cord-020235-stcrozdw 517 18 . . . cord-020235-stcrozdw 518 1 A a DT cord-020235-stcrozdw 518 2 product product NN cord-020235-stcrozdw 518 3 analysis analysis NN cord-020235-stcrozdw 518 4 revealed reveal VBD cord-020235-stcrozdw 518 5 that that IN cord-020235-stcrozdw 518 6 six six CD cord-020235-stcrozdw 518 7 viral viral JJ cord-020235-stcrozdw 518 8 polypeptides polypeptide NNS cord-020235-stcrozdw 518 9 are be VBP cord-020235-stcrozdw 518 10 phosphorylated phosphorylate VBN cord-020235-stcrozdw 518 11 . . . cord-020235-stcrozdw 519 1 The the DT cord-020235-stcrozdw 519 2 predominant predominant JJ cord-020235-stcrozdw 519 3 sites site NNS cord-020235-stcrozdw 519 4 of of IN cord-020235-stcrozdw 519 5 phosphorylation phosphorylation NN cord-020235-stcrozdw 519 6 are be VBP cord-020235-stcrozdw 519 7 the the DT cord-020235-stcrozdw 519 8 ( ( -LRB- cord-020235-stcrozdw 519 9 f f NNP cord-020235-stcrozdw 519 10 - - HYPH cord-020235-stcrozdw 519 11 OH OH NNP cord-020235-stcrozdw 519 12 groups group NNS cord-020235-stcrozdw 519 13 of of IN cord-020235-stcrozdw 519 14 serine serine NN cord-020235-stcrozdw 519 15 and and CC cord-020235-stcrozdw 519 16 threonine threonine NN cord-020235-stcrozdw 519 17 . . . cord-020235-stcrozdw 520 1 In in IN cord-020235-stcrozdw 520 2 1972 1972 CD cord-020235-stcrozdw 520 3 a a DT cord-020235-stcrozdw 520 4 herpesvirus herpesvirus NN cord-020235-stcrozdw 520 5 was be VBD cord-020235-stcrozdw 520 6 isolated isolate VBN cord-020235-stcrozdw 520 7 from from IN cord-020235-stcrozdw 520 8 young young JJ cord-020235-stcrozdw 520 9 goats goat NNS cord-020235-stcrozdw 520 10 with with IN cord-020235-stcrozdw 520 11 a a DT cord-020235-stcrozdw 520 12 severe severe JJ cord-020235-stcrozdw 520 13 generalized generalize VBN cord-020235-stcrozdw 520 14 infection infection NN cord-020235-stcrozdw 520 15 in in IN cord-020235-stcrozdw 520 16 California California NNP cord-020235-stcrozdw 520 17 . . . cord-020235-stcrozdw 521 1 This this DT cord-020235-stcrozdw 521 2 isolate isolate NN cord-020235-stcrozdw 521 3 has have VBZ cord-020235-stcrozdw 521 4 been be VBN cord-020235-stcrozdw 521 5 characterized characterize VBN cord-020235-stcrozdw 521 6 in in IN cord-020235-stcrozdw 521 7 some some DT cord-020235-stcrozdw 521 8 detail detail NN cord-020235-stcrozdw 521 9 and and CC cord-020235-stcrozdw 521 10 named name VBN cord-020235-stcrozdw 521 11 caprine caprine NN cord-020235-stcrozdw 521 12 herpesvirus herpesvirus NNP cord-020235-stcrozdw 521 13 1 1 CD cord-020235-stcrozdw 521 14 . . . cord-020235-stcrozdw 522 1 Recently recently RB cord-020235-stcrozdw 522 2 a a DT cord-020235-stcrozdw 522 3 herpesvirus herpesvirus NN cord-020235-stcrozdw 522 4 was be VBD cord-020235-stcrozdw 522 5 isolated isolate VBN cord-020235-stcrozdw 522 6 in in IN cord-020235-stcrozdw 522 7 Switzerland Switzerland NNP cord-020235-stcrozdw 522 8 from from IN cord-020235-stcrozdw 522 9 goats goat NNS cord-020235-stcrozdw 522 10 with with IN cord-020235-stcrozdw 522 11 a a DT cord-020235-stcrozdw 522 12 similar similar JJ cord-020235-stcrozdw 522 13 infection infection NN cord-020235-stcrozdw 522 14 . . . cord-020235-stcrozdw 523 1 We -PRON- PRP cord-020235-stcrozdw 523 2 report report VBP cord-020235-stcrozdw 523 3 a a DT cord-020235-stcrozdw 523 4 further further JJ cord-020235-stcrozdw 523 5 characterization characterization NN cord-020235-stcrozdw 523 6 of of IN cord-020235-stcrozdw 523 7 both both DT cord-020235-stcrozdw 523 8 isolates isolate NNS cord-020235-stcrozdw 523 9 and and CC cord-020235-stcrozdw 523 10 propose propose VB cord-020235-stcrozdw 523 11 their -PRON- PRP$ cord-020235-stcrozdw 523 12 classification classification NN cord-020235-stcrozdw 523 13 as as IN cord-020235-stcrozdw 523 14 Bovid Bovid NNP cord-020235-stcrozdw 523 15 Herpesvirus Herpesvirus NNP cord-020235-stcrozdw 523 16 6 6 CD cord-020235-stcrozdw 523 17 ( ( -LRB- cord-020235-stcrozdw 523 18 BHV-6 BHV-6 NNP cord-020235-stcrozdw 523 19 ) ) -RRB- cord-020235-stcrozdw 523 20 . . . cord-020235-stcrozdw 524 1 -BHV-6 -BHV-6 NNP cord-020235-stcrozdw 524 2 multiplies multiply VBZ cord-020235-stcrozdw 524 3 rapidly rapidly RB cord-020235-stcrozdw 524 4 and and CC cord-020235-stcrozdw 524 5 shows show VBZ cord-020235-stcrozdw 524 6 a a DT cord-020235-stcrozdw 524 7 broad broad JJ cord-020235-stcrozdw 524 8 hostcell hostcell JJ cord-020235-stcrozdw 524 9 range range NN cord-020235-stcrozdw 524 10 . . . cord-020235-stcrozdw 525 1 Crossneutralization Crossneutralization NNP cord-020235-stcrozdw 525 2 onl onl NNP cord-020235-stcrozdw 525 3 y y NNP cord-020235-stcrozdw 525 4 could could MD cord-020235-stcrozdw 525 5 be be VB cord-020235-stcrozdw 525 6 observed observe VBN cord-020235-stcrozdw 525 7 with with IN cord-020235-stcrozdw 525 8 BHV-1 BHV-1 NNP cord-020235-stcrozdw 525 9 ( ( -LRB- cord-020235-stcrozdw 525 10 IBR IBR NNP cord-020235-stcrozdw 525 11 / / SYM cord-020235-stcrozdw 525 12 IPV IPV NNP cord-020235-stcrozdw 525 13 - - HYPH cord-020235-stcrozdw 525 14 Virus Virus NNP cord-020235-stcrozdw 525 15 ) ) -RRB- cord-020235-stcrozdw 525 16 , , , cord-020235-stcrozdw 525 17 in in IN cord-020235-stcrozdw 525 18 a a DT cord-020235-stcrozdw 525 19 one one CD cord-020235-stcrozdw 525 20 way way NN cord-020235-stcrozdw 525 21 reaction reaction NN cord-020235-stcrozdw 525 22 . . . cord-020235-stcrozdw 526 1 In in IN cord-020235-stcrozdw 526 2 gel gel NN cord-020235-stcrozdw 526 3 immunoelectrophoresis immunoelectrophoresis NN cord-020235-stcrozdw 526 4 the the DT cord-020235-stcrozdw 526 5 serologic serologic NNP cord-020235-stcrozdw 526 6 relationship relationship NN cord-020235-stcrozdw 526 7 envolved envolve VBD cord-020235-stcrozdw 526 8 the the DT cord-020235-stcrozdw 526 9 major major JJ cord-020235-stcrozdw 526 10 antigenic antigenic JJ cord-020235-stcrozdw 526 11 components component NNS cord-020235-stcrozdw 526 12 of of IN cord-020235-stcrozdw 526 13 BHV-1 BHV-1 NNP cord-020235-stcrozdw 526 14 . . . cord-020235-stcrozdw 527 1 We -PRON- PRP cord-020235-stcrozdw 527 2 have have VBP cord-020235-stcrozdw 527 3 evaluated evaluate VBN cord-020235-stcrozdw 527 4 two two CD cord-020235-stcrozdw 527 5 methods method NNS cord-020235-stcrozdw 527 6 for for IN cord-020235-stcrozdw 527 7 the the DT cord-020235-stcrozdw 527 8 analysis analysis NN cord-020235-stcrozdw 527 9 of of IN cord-020235-stcrozdw 527 10 antibodies antibody NNS cord-020235-stcrozdw 527 11 directed direct VBN cord-020235-stcrozdw 527 12 against against IN cord-020235-stcrozdw 527 13 EBVspecified EBVspecified NNP cord-020235-stcrozdw 527 14 proteins protein NNS cord-020235-stcrozdw 527 15 : : : cord-020235-stcrozdw 527 16 1 1 CD cord-020235-stcrozdw 527 17 . . . cord-020235-stcrozdw 528 1 Indirect indirect JJ cord-020235-stcrozdw 528 2 immunoprecipitation immunoprecipitation NN cord-020235-stcrozdw 528 3 ( ( -LRB- cord-020235-stcrozdw 528 4 IP IP NNP cord-020235-stcrozdw 528 5 ) ) -RRB- cord-020235-stcrozdw 528 6 and and CC cord-020235-stcrozdw 528 7 2 2 CD cord-020235-stcrozdw 528 8 . . . cord-020235-stcrozdw 529 1 Radioimmunoassay Radioimmunoassay NNP cord-020235-stcrozdw 529 2 of of IN cord-020235-stcrozdw 529 3 electroblots electroblot NNS cord-020235-stcrozdw 529 4 of of IN cord-020235-stcrozdw 529 5 SDS SDS NNP cord-020235-stcrozdw 529 6 PAGE PAGE NNP cord-020235-stcrozdw 529 7 separated separate VBD cord-020235-stcrozdw 529 8 EBV EBV NNP cord-020235-stcrozdw 529 9 - - HYPH cord-020235-stcrozdw 529 10 specified specify VBN cord-020235-stcrozdw 529 11 proteins protein NNS cord-020235-stcrozdw 529 12 ( ( -LRB- cord-020235-stcrozdw 529 13 RIAB RIAB NNP cord-020235-stcrozdw 529 14 ) ) -RRB- cord-020235-stcrozdw 529 15 . . . cord-020235-stcrozdw 530 1 Using use VBG cord-020235-stcrozdw 530 2 IP ip NN cord-020235-stcrozdw 530 3 we -PRON- PRP cord-020235-stcrozdw 530 4 have have VBP cord-020235-stcrozdw 530 5 identified identify VBN cord-020235-stcrozdw 530 6 20 20 CD cord-020235-stcrozdw 530 7 proteins protein NNS cord-020235-stcrozdw 530 8 against against IN cord-020235-stcrozdw 530 9 which which WDT cord-020235-stcrozdw 530 10 antibodies antibody NNS cord-020235-stcrozdw 530 11 are be VBP cord-020235-stcrozdw 530 12 made make VBN cord-020235-stcrozdw 530 13 during during IN cord-020235-stcrozdw 530 14 infection infection NN cord-020235-stcrozdw 530 15 , , , cord-020235-stcrozdw 530 16 some some DT cord-020235-stcrozdw 530 17 of of IN cord-020235-stcrozdw 530 18 these these DT cord-020235-stcrozdw 530 19 proteins protein NNS cord-020235-stcrozdw 530 20 have have VBP cord-020235-stcrozdw 530 21 also also RB cord-020235-stcrozdw 530 22 been be VBN cord-020235-stcrozdw 530 23 found find VBN cord-020235-stcrozdw 530 24 using use VBG cord-020235-stcrozdw 530 25 the the DT cord-020235-stcrozdw 530 26 latter latter JJ cord-020235-stcrozdw 530 27 technique technique NN cord-020235-stcrozdw 530 28 . . . cord-020235-stcrozdw 531 1 Many many JJ cord-020235-stcrozdw 531 2 of of IN cord-020235-stcrozdw 531 3 the the DT cord-020235-stcrozdw 531 4 proteins protein NNS cord-020235-stcrozdw 531 5 are be VBP cord-020235-stcrozdw 531 6 only only RB cord-020235-stcrozdw 531 7 reactive reactive JJ cord-020235-stcrozdw 531 8 with with IN cord-020235-stcrozdw 531 9 EA'VCA+ EA'VCA+ NNP cord-020235-stcrozdw 531 10 sera sera NNP cord-020235-stcrozdw 531 11 and and CC cord-020235-stcrozdw 531 12 not not RB cord-020235-stcrozdw 531 13 ractive ractive VB cord-020235-stcrozdw 531 14 with with IN cord-020235-stcrozdw 531 15 EA EA NNP cord-020235-stcrozdw 531 16 - - HYPH cord-020235-stcrozdw 531 17 VCA VCA NNP cord-020235-stcrozdw 531 18 + + CC cord-020235-stcrozdw 531 19 sera sera NNP cord-020235-stcrozdw 531 20 and and CC cord-020235-stcrozdw 531 21 may may MD cord-020235-stcrozdw 531 22 therefore therefore RB cord-020235-stcrozdw 531 23 be be VB cord-020235-stcrozdw 531 24 candidates candidate NNS cord-020235-stcrozdw 531 25 for for IN cord-020235-stcrozdw 531 26 the the DT cord-020235-stcrozdw 531 27 EA EA NNP cord-020235-stcrozdw 531 28 specifying specify VBG cord-020235-stcrozdw 531 29 proteins protein NNS cord-020235-stcrozdw 531 30 . . . cord-020235-stcrozdw 532 1 It -PRON- PRP cord-020235-stcrozdw 532 2 seems seem VBZ cord-020235-stcrozdw 532 3 likely likely JJ cord-020235-stcrozdw 532 4 that that IN cord-020235-stcrozdw 532 5 the the DT cord-020235-stcrozdw 532 6 failure failure NN cord-020235-stcrozdw 532 7 to to TO cord-020235-stcrozdw 532 8 identify identify VB cord-020235-stcrozdw 532 9 all all DT cord-020235-stcrozdw 532 10 proteins protein NNS cord-020235-stcrozdw 532 11 using use VBG cord-020235-stcrozdw 532 12 the the DT cord-020235-stcrozdw 532 13 RIAB RIAB NNP cord-020235-stcrozdw 532 14 technique technique NN cord-020235-stcrozdw 532 15 is be VBZ cord-020235-stcrozdw 532 16 probably probably RB cord-020235-stcrozdw 532 17 due due JJ cord-020235-stcrozdw 532 18 to to IN cord-020235-stcrozdw 532 19 the the DT cord-020235-stcrozdw 532 20 strong strong JJ cord-020235-stcrozdw 532 21 denaturating denaturating NN cord-020235-stcrozdw 532 22 conditions condition NNS cord-020235-stcrozdw 532 23 used use VBN cord-020235-stcrozdw 532 24 during during IN cord-020235-stcrozdw 532 25 the the DT cord-020235-stcrozdw 532 26 SDS SDS NNP cord-020235-stcrozdw 532 27 PAGE PAGE NNP cord-020235-stcrozdw 532 28 step step NN cord-020235-stcrozdw 532 29 . . . cord-020235-stcrozdw 533 1 Only only RB cord-020235-stcrozdw 533 2 those those DT cord-020235-stcrozdw 533 3 antibodies antibody NNS cord-020235-stcrozdw 533 4 directed direct VBN cord-020235-stcrozdw 533 5 towards towards IN cord-020235-stcrozdw 533 6 the the DT cord-020235-stcrozdw 533 7 primary primary JJ cord-020235-stcrozdw 533 8 sequence sequence NN cord-020235-stcrozdw 533 9 of of IN cord-020235-stcrozdw 533 10 the the DT cord-020235-stcrozdw 533 11 protein protein NN cord-020235-stcrozdw 533 12 will will MD cord-020235-stcrozdw 533 13 react react VB cord-020235-stcrozdw 533 14 with with IN cord-020235-stcrozdw 533 15 the the DT cord-020235-stcrozdw 533 16 blotted blot VBN cord-020235-stcrozdw 533 17 proteins protein NNS cord-020235-stcrozdw 533 18 , , , cord-020235-stcrozdw 533 19 whereas whereas IN cord-020235-stcrozdw 533 20 with with IN cord-020235-stcrozdw 533 21 IP ip NN cord-020235-stcrozdw 533 22 analysis analysis NN cord-020235-stcrozdw 533 23 the the DT cord-020235-stcrozdw 533 24 native native JJ cord-020235-stcrozdw 533 25 proteins protein NNS cord-020235-stcrozdw 533 26 are be VBP cord-020235-stcrozdw 533 27 available available JJ cord-020235-stcrozdw 533 28 for for IN cord-020235-stcrozdw 533 29 interaction interaction NN cord-020235-stcrozdw 533 30 with with IN cord-020235-stcrozdw 533 31 the the DT cord-020235-stcrozdw 533 32 sera sera NNP cord-020235-stcrozdw 533 33 . . . cord-020235-stcrozdw 534 1 Previousl Previousl NNP cord-020235-stcrozdw 534 2 y y NNP cord-020235-stcrozdw 535 1 we -PRON- PRP cord-020235-stcrozdw 535 2 demonstrated demonstrate VBD cord-020235-stcrozdw 535 3 that that IN cord-020235-stcrozdw 535 4 the the DT cord-020235-stcrozdw 535 5 synthesis synthesis NN cord-020235-stcrozdw 535 6 of of IN cord-020235-stcrozdw 535 7 EBV EBV NNP cord-020235-stcrozdw 535 8 - - HYPH cord-020235-stcrozdw 535 9 induced induce VBN cord-020235-stcrozdw 535 10 proteins protein NNS cord-020235-stcrozdw 535 11 in in IN cord-020235-stcrozdw 535 12 superinfected superinfect VBN cord-020235-stcrozdw 535 13 Raji Raji NNP cord-020235-stcrozdw 535 14 cells cell NNS cord-020235-stcrozdw 535 15 ( ( -LRB- cord-020235-stcrozdw 535 16 Raji Raji NNP cord-020235-stcrozdw 535 17 51 51 CD cord-020235-stcrozdw 535 18 ) ) -RRB- cord-020235-stcrozdw 535 19 could could MD cord-020235-stcrozdw 535 20 be be VB cord-020235-stcrozdw 535 21 divided divide VBN cord-020235-stcrozdw 535 22 into into IN cord-020235-stcrozdw 535 23 3 3 CD cord-020235-stcrozdw 535 24 phases phase NNS cord-020235-stcrozdw 535 25 : : : cord-020235-stcrozdw 535 26 Primary primary JJ cord-020235-stcrozdw 535 27 , , , cord-020235-stcrozdw 535 28 secondary secondary JJ cord-020235-stcrozdw 535 29 and and CC cord-020235-stcrozdw 535 30 tertiary tertiary JJ cord-020235-stcrozdw 535 31 ( ( -LRB- cord-020235-stcrozdw 535 32 Bay Bay NNP cord-020235-stcrozdw 535 33 - - HYPH cord-020235-stcrozdw 535 34 liss liss NNP cord-020235-stcrozdw 535 35 and and CC cord-020235-stcrozdw 535 36 Wolf Wolf NNP cord-020235-stcrozdw 535 37 , , , cord-020235-stcrozdw 535 38 J. J. NNP cord-020235-stcrozdw 535 39 Gen. Gen. NNP cord-020235-stcrozdw 535 40 Virol Virol NNP cord-020235-stcrozdw 535 41 . . NNP cord-020235-stcrozdw 535 42 , , , cord-020235-stcrozdw 535 43 1981 1981 CD cord-020235-stcrozdw 535 44 , , , cord-020235-stcrozdw 535 45 in in IN cord-020235-stcrozdw 535 46 press press NN cord-020235-stcrozdw 535 47 ) ) -RRB- cord-020235-stcrozdw 535 48 . . . cord-020235-stcrozdw 536 1 Recent recent JJ cord-020235-stcrozdw 536 2 experiments experiment NNS cord-020235-stcrozdw 536 3 show show VBP cord-020235-stcrozdw 536 4 that that IN cord-020235-stcrozdw 536 5 incubation incubation NN cord-020235-stcrozdw 536 6 of of IN cord-020235-stcrozdw 536 7 Raji Raji NNP cord-020235-stcrozdw 536 8 SI SI NNP cord-020235-stcrozdw 536 9 in in IN cord-020235-stcrozdw 536 10 the the DT cord-020235-stcrozdw 536 11 presence presence NN cord-020235-stcrozdw 536 12 of of IN cord-020235-stcrozdw 536 13 canavanine canavanine NNP cord-020235-stcrozdw 536 14 and and CC cord-020235-stcrozdw 536 15 the the DT cord-020235-stcrozdw 536 16 absence absence NN cord-020235-stcrozdw 536 17 of of IN cord-020235-stcrozdw 536 18 arginine arginine NN cord-020235-stcrozdw 536 19 allows allow VBZ cord-020235-stcrozdw 536 20 only only RB cord-020235-stcrozdw 536 21 a a DT cord-020235-stcrozdw 536 22 limited limited JJ cord-020235-stcrozdw 536 23 expression expression NN cord-020235-stcrozdw 536 24 of of IN cord-020235-stcrozdw 536 25 the the DT cord-020235-stcrozdw 536 26 viral viral JJ cord-020235-stcrozdw 536 27 genome genome NN cord-020235-stcrozdw 536 28 . . . cord-020235-stcrozdw 537 1 If if IN cord-020235-stcrozdw 537 2 the the DT cord-020235-stcrozdw 537 3 cells cell NNS cord-020235-stcrozdw 537 4 are be VBP cord-020235-stcrozdw 537 5 released release VBN cord-020235-stcrozdw 537 6 from from IN cord-020235-stcrozdw 537 7 a a DT cord-020235-stcrozdw 537 8 canavanine canavanine NN cord-020235-stcrozdw 537 9 block block NN cord-020235-stcrozdw 537 10 ( ( -LRB- cord-020235-stcrozdw 537 11 applied apply VBN cord-020235-stcrozdw 537 12 from from IN cord-020235-stcrozdw 537 13 0 0 CD cord-020235-stcrozdw 537 14 to to IN cord-020235-stcrozdw 537 15 8 8 CD cord-020235-stcrozdw 537 16 h h NN cord-020235-stcrozdw 537 17 post post NN cord-020235-stcrozdw 537 18 infection infection NN cord-020235-stcrozdw 537 19 ) ) -RRB- cord-020235-stcrozdw 537 20 then then RB cord-020235-stcrozdw 537 21 between between IN cord-020235-stcrozdw 537 22 2 2 CD cord-020235-stcrozdw 537 23 and and CC cord-020235-stcrozdw 537 24 4 4 CD cord-020235-stcrozdw 537 25 h h NNP cord-020235-stcrozdw 537 26 later later RBR cord-020235-stcrozdw 537 27 several several JJ cord-020235-stcrozdw 537 28 new new JJ cord-020235-stcrozdw 537 29 proteins protein NNS cord-020235-stcrozdw 537 30 are be VBP cord-020235-stcrozdw 537 31 synthesized synthesize VBN cord-020235-stcrozdw 537 32 , , , cord-020235-stcrozdw 537 33 however however RB cord-020235-stcrozdw 537 34 , , , cord-020235-stcrozdw 537 35 if if IN cord-020235-stcrozdw 537 36 m m NNP cord-020235-stcrozdw 537 37 - - HYPH cord-020235-stcrozdw 537 38 RNA RNA NNP cord-020235-stcrozdw 537 39 synthesis synthesis NN cord-020235-stcrozdw 537 40 is be VBZ cord-020235-stcrozdw 537 41 inhibited inhibit VBN cord-020235-stcrozdw 537 42 ( ( -LRB- cord-020235-stcrozdw 537 43 with with IN cord-020235-stcrozdw 537 44 actinomycin actinomycin NNS cord-020235-stcrozdw 537 45 D D NNP cord-020235-stcrozdw 537 46 ) ) -RRB- cord-020235-stcrozdw 537 47 after after IN cord-020235-stcrozdw 537 48 removal removal NN cord-020235-stcrozdw 537 49 of of IN cord-020235-stcrozdw 537 50 the the DT cord-020235-stcrozdw 537 51 canavanine canavanine NN cord-020235-stcrozdw 538 1 then then RB cord-020235-stcrozdw 538 2 these these DT cord-020235-stcrozdw 538 3 new new JJ cord-020235-stcrozdw 538 4 proteins protein NNS cord-020235-stcrozdw 538 5 fail fail VBP cord-020235-stcrozdw 538 6 to to TO cord-020235-stcrozdw 538 7 appear appear VB cord-020235-stcrozdw 538 8 . . . cord-020235-stcrozdw 539 1 Amongst amongst IN cord-020235-stcrozdw 539 2 these these DT cord-020235-stcrozdw 539 3 proteins protein NNS cord-020235-stcrozdw 539 4 are be VBP cord-020235-stcrozdw 539 5 members member NNS cord-020235-stcrozdw 539 6 of of IN cord-020235-stcrozdw 539 7 the the DT cord-020235-stcrozdw 539 8 EBV EBV NNP cord-020235-stcrozdw 539 9 - - HYPH cord-020235-stcrozdw 539 10 specified specify VBN cord-020235-stcrozdw 539 11 early early JJ cord-020235-stcrozdw 539 12 antigen antigen NN cord-020235-stcrozdw 539 13 complex complex NN cord-020235-stcrozdw 539 14 ( ( -LRB- cord-020235-stcrozdw 539 15 EA EA NNP cord-020235-stcrozdw 539 16 ) ) -RRB- cord-020235-stcrozdw 539 17 . . . cord-020235-stcrozdw 540 1 These these DT cord-020235-stcrozdw 540 2 results result NNS cord-020235-stcrozdw 540 3 indicate indicate VBP cord-020235-stcrozdw 540 4 that that IN cord-020235-stcrozdw 540 5 an an DT cord-020235-stcrozdw 540 6 arginine arginine NN cord-020235-stcrozdw 540 7 - - HYPH cord-020235-stcrozdw 540 8 containing contain VBG cord-020235-stcrozdw 540 9 protein protein NN cord-020235-stcrozdw 540 10 is be VBZ cord-020235-stcrozdw 540 11 synthesized synthesize VBN cord-020235-stcrozdw 540 12 soon soon RB cord-020235-stcrozdw 540 13 after after IN cord-020235-stcrozdw 540 14 infection infection NN cord-020235-stcrozdw 540 15 and and CC cord-020235-stcrozdw 540 16 that that IN cord-020235-stcrozdw 540 17 this this DT cord-020235-stcrozdw 540 18 protein protein NN cord-020235-stcrozdw 540 19 is be VBZ cord-020235-stcrozdw 540 20 required require VBN cord-020235-stcrozdw 540 21 in in IN cord-020235-stcrozdw 540 22 an an DT cord-020235-stcrozdw 540 23 active active JJ cord-020235-stcrozdw 540 24 form form NN cord-020235-stcrozdw 540 25 in in IN cord-020235-stcrozdw 540 26 order order NN cord-020235-stcrozdw 540 27 to to TO cord-020235-stcrozdw 540 28 synthesize synthesize VB cord-020235-stcrozdw 540 29 m m NNP cord-020235-stcrozdw 540 30 - - NNP cord-020235-stcrozdw 540 31 RNA RNA NNP cord-020235-stcrozdw 540 32 for for IN cord-020235-stcrozdw 540 33 the the DT cord-020235-stcrozdw 540 34 secondary secondary JJ cord-020235-stcrozdw 540 35 group group NN cord-020235-stcrozdw 540 36 of of IN cord-020235-stcrozdw 540 37 proteins protein NNS cord-020235-stcrozdw 540 38 . . . cord-020235-stcrozdw 541 1 Amongst amongst IN cord-020235-stcrozdw 541 2 these these DT cord-020235-stcrozdw 541 3 proteins protein NNS cord-020235-stcrozdw 541 4 are be VBP cord-020235-stcrozdw 541 5 the the DT cord-020235-stcrozdw 541 6 major major JJ cord-020235-stcrozdw 541 7 components component NNS cord-020235-stcrozdw 541 8 of of IN cord-020235-stcrozdw 541 9 the the DT cord-020235-stcrozdw 541 10 early early JJ cord-020235-stcrozdw 541 11 antigen antigen NN cord-020235-stcrozdw 541 12 ( ( -LRB- cord-020235-stcrozdw 541 13 EA EA NNP cord-020235-stcrozdw 541 14 ) ) -RRB- cord-020235-stcrozdw 541 15 complex complex NN cord-020235-stcrozdw 541 16 . . . cord-020235-stcrozdw 542 1 Max Max NNP cord-020235-stcrozdw 542 2 von von NNP cord-020235-stcrozdw 542 3 Pettenkofer Pettenkofer NNP cord-020235-stcrozdw 542 4 Inst Inst NNP cord-020235-stcrozdw 542 5 . . . cord-020235-stcrozdw 543 1 , , , cord-020235-stcrozdw 543 2 Univ Univ NNP cord-020235-stcrozdw 543 3 . . NNP cord-020235-stcrozdw 543 4 , , , cord-020235-stcrozdw 543 5 D-8000 d-8000 CD cord-020235-stcrozdw 543 6 Miinchen Miinchen NNP cord-020235-stcrozdw 543 7 2 2 CD cord-020235-stcrozdw 543 8 ; ; : cord-020235-stcrozdw 543 9 ENT ENT NNP cord-020235-stcrozdw 543 10 - - HYPH cord-020235-stcrozdw 543 11 Klinik Klinik NNP cord-020235-stcrozdw 543 12 , , , cord-020235-stcrozdw 543 13 Univ Univ NNP cord-020235-stcrozdw 543 14 . . . cord-020235-stcrozdw 544 1 , , , cord-020235-stcrozdw 544 2 D-8700 d-8700 VB cord-020235-stcrozdw 544 3 Wiirzburg Wiirzburg NNP cord-020235-stcrozdw 544 4 ; ; : cord-020235-stcrozdw 544 5 Dept Dept NNP cord-020235-stcrozdw 544 6 . . . cord-020235-stcrozdw 544 7 Tumor tumor NN cord-020235-stcrozdw 544 8 Virology Virology NNP cord-020235-stcrozdw 544 9 , , , cord-020235-stcrozdw 544 10 Chinese chinese JJ cord-020235-stcrozdw 544 11 Acad Acad NNP cord-020235-stcrozdw 544 12 . . . cord-020235-stcrozdw 545 1 Med Med NNP cord-020235-stcrozdw 545 2 . . . cord-020235-stcrozdw 546 1 Sci Sci NNP cord-020235-stcrozdw 546 2 . . . cord-020235-stcrozdw 547 1 , , , cord-020235-stcrozdw 547 2 Beijing Beijing NNP cord-020235-stcrozdw 547 3 , , , cord-020235-stcrozdw 547 4 China China NNP cord-020235-stcrozdw 547 5 SEIBL SEIBL NNP cord-020235-stcrozdw 547 6 , , , cord-020235-stcrozdw 547 7 R. R. NNP cord-020235-stcrozdw 547 8 , , , cord-020235-stcrozdw 547 9 RICHTER RICHTER NNP cord-020235-stcrozdw 547 10 , , , cord-020235-stcrozdw 547 11 W. W. NNP cord-020235-stcrozdw 547 12 , , , cord-020235-stcrozdw 547 13 ZENG ZENG NNP cord-020235-stcrozdw 547 14 , , , cord-020235-stcrozdw 547 15 Y. Y. NNP cord-020235-stcrozdw 547 16 , , , cord-020235-stcrozdw 547 17 GU GU NNP cord-020235-stcrozdw 547 18 , , , cord-020235-stcrozdw 547 19 S.-Y. S.-Y. NNP cord-020235-stcrozdw 547 20 , , , cord-020235-stcrozdw 547 21 and and CC cord-020235-stcrozdw 547 22 WOLF WOLF NNP cord-020235-stcrozdw 547 23 , , , cord-020235-stcrozdw 547 24 H. H. NNP cord-020235-stcrozdw 547 25 Antibody Antibody NNP cord-020235-stcrozdw 547 26 titers titer NNS cord-020235-stcrozdw 547 27 of of IN cord-020235-stcrozdw 547 28 IgA IgA NNP cord-020235-stcrozdw 547 29 antivirus antivirus NNP cord-020235-stcrozdw 547 30 capsid capsid NN cord-020235-stcrozdw 547 31 antigen antigen NNP cord-020235-stcrozdw 547 32 ( ( -LRB- cord-020235-stcrozdw 547 33 VCA VCA NNP cord-020235-stcrozdw 547 34 ) ) -RRB- cord-020235-stcrozdw 547 35 can can MD cord-020235-stcrozdw 547 36 be be VB cord-020235-stcrozdw 547 37 used use VBN cord-020235-stcrozdw 547 38 for for IN cord-020235-stcrozdw 547 39 screening screen VBG cord-020235-stcrozdw 547 40 early early JJ cord-020235-stcrozdw 547 41 tumor tumor NN cord-020235-stcrozdw 547 42 cases case NNS cord-020235-stcrozdw 547 43 , , , cord-020235-stcrozdw 547 44 confirming confirm VBG cord-020235-stcrozdw 547 45 histological histological JJ cord-020235-stcrozdw 547 46 diagnoses diagnosis NNS cord-020235-stcrozdw 547 47 and and CC cord-020235-stcrozdw 547 48 longtime longtime JJ cord-020235-stcrozdw 547 49 surveillance surveillance NN cord-020235-stcrozdw 547 50 of of IN cord-020235-stcrozdw 547 51 therapy therapy NN cord-020235-stcrozdw 547 52 . . . cord-020235-stcrozdw 548 1 However however RB cord-020235-stcrozdw 548 2 , , , cord-020235-stcrozdw 548 3 in in IN cord-020235-stcrozdw 548 4 high high JJ cord-020235-stcrozdw 548 5 risk risk NN cord-020235-stcrozdw 548 6 areas area NNS cord-020235-stcrozdw 548 7 ( ( -LRB- cord-020235-stcrozdw 548 8 S. S. NNP cord-020235-stcrozdw 548 9 China China NNP cord-020235-stcrozdw 548 10 , , , cord-020235-stcrozdw 548 11 incidence incidence NN cord-020235-stcrozdw 548 12 of of IN cord-020235-stcrozdw 548 13 NPC NPC NNP cord-020235-stcrozdw 548 14 : : : cord-020235-stcrozdw 548 15 20/10 20/10 CD cord-020235-stcrozdw 548 16 5 5 CD cord-020235-stcrozdw 548 17 ) ) -RRB- cord-020235-stcrozdw 548 18 2 2 CD cord-020235-stcrozdw 548 19 % % NN cord-020235-stcrozdw 548 20 of of IN cord-020235-stcrozdw 548 21 the the DT cord-020235-stcrozdw 548 22 population population NN cord-020235-stcrozdw 548 23 have have VBP cord-020235-stcrozdw 548 24 IgA IgA NNP cord-020235-stcrozdw 548 25 anti anti NNP cord-020235-stcrozdw 548 26 VCA VCA NNP cord-020235-stcrozdw 548 27 antibody antibody NN cord-020235-stcrozdw 548 28 indicating indicate VBG cord-020235-stcrozdw 548 29 a a DT cord-020235-stcrozdw 548 30 need need NN cord-020235-stcrozdw 548 31 for for IN cord-020235-stcrozdw 548 32 methods method NNS cord-020235-stcrozdw 548 33 which which WDT cord-020235-stcrozdw 548 34 allow allow VBP cord-020235-stcrozdw 548 35 monitoring monitoring NN cord-020235-stcrozdw 548 36 of of IN cord-020235-stcrozdw 548 37 additional additional JJ cord-020235-stcrozdw 548 38 parameters parameter NNS cord-020235-stcrozdw 548 39 for for IN cord-020235-stcrozdw 548 40 deciding decide VBG cord-020235-stcrozdw 548 41 on on IN cord-020235-stcrozdw 548 42 the the DT cord-020235-stcrozdw 548 43 need need NN cord-020235-stcrozdw 548 44 for for IN cord-020235-stcrozdw 548 45 therapy therapy NN cord-020235-stcrozdw 548 46 . . . cord-020235-stcrozdw 549 1 The the DT cord-020235-stcrozdw 549 2 same same JJ cord-020235-stcrozdw 549 3 need need NN cord-020235-stcrozdw 549 4 exists exist VBZ cord-020235-stcrozdw 549 5 in in IN cord-020235-stcrozdw 549 6 case case NN cord-020235-stcrozdw 549 7 of of IN cord-020235-stcrozdw 549 8 long long JJ cord-020235-stcrozdw 549 9 term term NN cord-020235-stcrozdw 549 10 ( ( -LRB- cord-020235-stcrozdw 549 11 1 1 CD cord-020235-stcrozdw 549 12 - - SYM cord-020235-stcrozdw 549 13 2 2 CD cord-020235-stcrozdw 549 14 years year NNS cord-020235-stcrozdw 549 15 ) ) -RRB- cord-020235-stcrozdw 549 16 survivors survivor NNS cord-020235-stcrozdw 549 17 of of IN cord-020235-stcrozdw 549 18 NPC NPC NNP cord-020235-stcrozdw 549 19 with with IN cord-020235-stcrozdw 549 20 constant constant JJ cord-020235-stcrozdw 549 21 IgA IgA NNP cord-020235-stcrozdw 549 22 anti anti NNP cord-020235-stcrozdw 549 23 VCA VCA NNP cord-020235-stcrozdw 549 24 titers titer NNS cord-020235-stcrozdw 549 25 . . . cord-020235-stcrozdw 550 1 -We -We : cord-020235-stcrozdw 550 2 have have VBP cord-020235-stcrozdw 550 3 developed develop VBN cord-020235-stcrozdw 550 4 a a DT cord-020235-stcrozdw 550 5 system system NN cord-020235-stcrozdw 550 6 to to TO cord-020235-stcrozdw 550 7 collect collect VB cord-020235-stcrozdw 550 8 cell cell NN cord-020235-stcrozdw 550 9 specimens specimen NNS cord-020235-stcrozdw 550 10 by by IN cord-020235-stcrozdw 550 11 application application NN cord-020235-stcrozdw 550 12 of of IN cord-020235-stcrozdw 550 13 buffer buffer NN cord-020235-stcrozdw 550 14 to to IN cord-020235-stcrozdw 550 15 the the DT cord-020235-stcrozdw 550 16 tumor tumor NN cord-020235-stcrozdw 550 17 site site NN cord-020235-stcrozdw 550 18 and and CC cord-020235-stcrozdw 550 19 collection collection NN cord-020235-stcrozdw 550 20 of of IN cord-020235-stcrozdw 550 21 cells cell NNS cord-020235-stcrozdw 550 22 directly directly RB cord-020235-stcrozdw 550 23 on on IN cord-020235-stcrozdw 550 24 to to IN cord-020235-stcrozdw 550 25 nitrocellulose nitrocellulose NN cord-020235-stcrozdw 550 26 filters filter NNS cord-020235-stcrozdw 550 27 . . . cord-020235-stcrozdw 551 1 These these DT cord-020235-stcrozdw 551 2 cells cell NNS cord-020235-stcrozdw 551 3 can can MD cord-020235-stcrozdw 551 4 be be VB cord-020235-stcrozdw 551 5 examined examine VBN cord-020235-stcrozdw 551 6 cytologically cytologically RB cord-020235-stcrozdw 551 7 or or CC cord-020235-stcrozdw 551 8 for for IN cord-020235-stcrozdw 551 9 EBV EBV NNP cord-020235-stcrozdw 551 10 DNA DNA NNP cord-020235-stcrozdw 551 11 in in IN cord-020235-stcrozdw 551 12 nucleic nucleic JJ cord-020235-stcrozdw 551 13 acid acid NN cord-020235-stcrozdw 551 14 hybridization hybridization NN cord-020235-stcrozdw 551 15 . . . cord-020235-stcrozdw 552 1 For for IN cord-020235-stcrozdw 552 2 the the DT cord-020235-stcrozdw 552 3 latter latter JJ cord-020235-stcrozdw 552 4 tests test VBZ cord-020235-stcrozdw 552 5 a a DT cord-020235-stcrozdw 552 6 modification modification NN cord-020235-stcrozdw 552 7 of of IN cord-020235-stcrozdw 552 8 the the DT cord-020235-stcrozdw 552 9 Grunstein Grunstein NNP cord-020235-stcrozdw 552 10 Hogness Hogness NNP cord-020235-stcrozdw 552 11 colony colony NN cord-020235-stcrozdw 552 12 hybridization hybridization NN cord-020235-stcrozdw 552 13 test test NN cord-020235-stcrozdw 552 14 and and CC cord-020235-stcrozdw 552 15 cloned clone VBD cord-020235-stcrozdw 552 16 EBV EBV NNP cord-020235-stcrozdw 552 17 DNA DNA NNP cord-020235-stcrozdw 552 18 have have VBP cord-020235-stcrozdw 552 19 been be VBN cord-020235-stcrozdw 552 20 used use VBN cord-020235-stcrozdw 552 21 . . . cord-020235-stcrozdw 553 1 In in IN cord-020235-stcrozdw 553 2 reconstruction reconstruction NN cord-020235-stcrozdw 553 3 experiments experiment NNS cord-020235-stcrozdw 553 4 25 25 CD cord-020235-stcrozdw 553 5 virus virus NN cord-020235-stcrozdw 553 6 - - HYPH cord-020235-stcrozdw 553 7 producing produce VBG cord-020235-stcrozdw 553 8 cells cell NNS cord-020235-stcrozdw 553 9 could could MD cord-020235-stcrozdw 553 10 be be VB cord-020235-stcrozdw 553 11 detected detect VBN cord-020235-stcrozdw 553 12 . . . cord-020235-stcrozdw 554 1 Inst Inst NNP cord-020235-stcrozdw 554 2 . . . cord-020235-stcrozdw 555 1 f. f. NNP cord-020235-stcrozdw 555 2 klin klin NNP cord-020235-stcrozdw 555 3 . . . cord-020235-stcrozdw 556 1 Virologie Virologie NNP cord-020235-stcrozdw 556 2 , , , cord-020235-stcrozdw 556 3 Univ Univ NNP cord-020235-stcrozdw 556 4 . . NNP cord-020235-stcrozdw 556 5 , , , cord-020235-stcrozdw 556 6 D-8520 D-8520 NNS cord-020235-stcrozdw 556 7 Erlangen Erlangen NNP cord-020235-stcrozdw 556 8 - - HYPH cord-020235-stcrozdw 556 9 Niimberg Niimberg NNP cord-020235-stcrozdw 556 10 KEIL KEIL NNP cord-020235-stcrozdw 556 11 , , , cord-020235-stcrozdw 556 12 G. G. NNP cord-020235-stcrozdw 556 13 and and CC cord-020235-stcrozdw 556 14 FLECKENSTEIN FLECKENSTEIN NNP cord-020235-stcrozdw 556 15 , , , cord-020235-stcrozdw 556 16 B. B. NNP cord-020235-stcrozdw 557 1 After after IN cord-020235-stcrozdw 557 2 infection infection NN cord-020235-stcrozdw 557 3 of of IN cord-020235-stcrozdw 557 4 permissive permissive JJ cord-020235-stcrozdw 557 5 cell cell NN cord-020235-stcrozdw 557 6 cultures culture NNS cord-020235-stcrozdw 557 7 with with IN cord-020235-stcrozdw 557 8 overlapping overlap VBG cord-020235-stcrozdw 557 9 restriction restriction NN cord-020235-stcrozdw 557 10 - - HYPH cord-020235-stcrozdw 557 11 fragments fragment NNS cord-020235-stcrozdw 557 12 of of IN cord-020235-stcrozdw 557 13 viral viral JJ cord-020235-stcrozdw 557 14 DNA dna NN cord-020235-stcrozdw 557 15 derived derive VBN cord-020235-stcrozdw 557 16 from from IN cord-020235-stcrozdw 557 17 different different JJ cord-020235-stcrozdw 557 18 strains strain NNS cord-020235-stcrozdw 557 19 of of IN cord-020235-stcrozdw 557 20 Herpesvirus Herpesvirus NNP cord-020235-stcrozdw 557 21 saimiri saimiri NNP cord-020235-stcrozdw 557 22 ( ( -LRB- cord-020235-stcrozdw 557 23 H. H. NNP cord-020235-stcrozdw 557 24 saimiri saimiri NNP cord-020235-stcrozdw 557 25 ) ) -RRB- cord-020235-stcrozdw 558 1 a a DT cord-020235-stcrozdw 558 2 number number NN cord-020235-stcrozdw 558 3 of of IN cord-020235-stcrozdw 558 4 recombinants recombinant NNS cord-020235-stcrozdw 558 5 could could MD cord-020235-stcrozdw 558 6 be be VB cord-020235-stcrozdw 558 7 isolated isolate VBN cord-020235-stcrozdw 558 8 . . . cord-020235-stcrozdw 559 1 The the DT cord-020235-stcrozdw 559 2 analysis analysis NN cord-020235-stcrozdw 559 3 of of IN cord-020235-stcrozdw 559 4 the the DT cord-020235-stcrozdw 559 5 viral viral JJ cord-020235-stcrozdw 559 6 proteins protein NNS cord-020235-stcrozdw 559 7 of of IN cord-020235-stcrozdw 559 8 the the DT cord-020235-stcrozdw 559 9 wt wt NN cord-020235-stcrozdw 559 10 - - HYPH cord-020235-stcrozdw 559 11 strains strain NNS cord-020235-stcrozdw 559 12 11 11 CD cord-020235-stcrozdw 559 13 , , , cord-020235-stcrozdw 559 14 OMI OMI NNP cord-020235-stcrozdw 559 15 and and CC cord-020235-stcrozdw 559 16 S295C S295C NNP cord-020235-stcrozdw 559 17 led lead VBD cord-020235-stcrozdw 559 18 to to IN cord-020235-stcrozdw 559 19 the the DT cord-020235-stcrozdw 559 20 identification identification NN cord-020235-stcrozdw 559 21 of of IN cord-020235-stcrozdw 559 22 four four CD cord-020235-stcrozdw 559 23 proteins protein NNS cord-020235-stcrozdw 559 24 that that WDT cord-020235-stcrozdw 559 25 differed differ VBD cord-020235-stcrozdw 559 26 within within IN cord-020235-stcrozdw 559 27 these these DT cord-020235-stcrozdw 559 28 strains strain NNS cord-020235-stcrozdw 559 29 with with IN cord-020235-stcrozdw 559 30 respect respect NN cord-020235-stcrozdw 559 31 to to IN cord-020235-stcrozdw 559 32 molecular molecular JJ cord-020235-stcrozdw 559 33 weight weight NN cord-020235-stcrozdw 559 34 . . . cord-020235-stcrozdw 560 1 We -PRON- PRP cord-020235-stcrozdw 560 2 are be VBP cord-020235-stcrozdw 560 3 able able JJ cord-020235-stcrozdw 560 4 to to TO cord-020235-stcrozdw 560 5 localize localize VB cord-020235-stcrozdw 560 6 these these DT cord-020235-stcrozdw 560 7 proteins protein NNS cord-020235-stcrozdw 560 8 in in IN cord-020235-stcrozdw 560 9 the the DT cord-020235-stcrozdw 560 10 internal internal JJ cord-020235-stcrozdw 560 11 region region NN cord-020235-stcrozdw 560 12 of of IN cord-020235-stcrozdw 560 13 the the DT cord-020235-stcrozdw 560 14 M M NNP cord-020235-stcrozdw 560 15 - - HYPH cord-020235-stcrozdw 560 16 DNA DNA NNP cord-020235-stcrozdw 560 17 by by IN cord-020235-stcrozdw 560 18 comparing compare VBG cord-020235-stcrozdw 560 19 the the DT cord-020235-stcrozdw 560 20 protein protein NN cord-020235-stcrozdw 560 21 patterns pattern NNS cord-020235-stcrozdw 560 22 of of IN cord-020235-stcrozdw 560 23 recombinant recombinant JJ cord-020235-stcrozdw 560 24 and and CC cord-020235-stcrozdw 560 25 parent parent NN cord-020235-stcrozdw 560 26 strains strain NNS cord-020235-stcrozdw 560 27 . . . cord-020235-stcrozdw 561 1 The the DT cord-020235-stcrozdw 561 2 exact exact JJ cord-020235-stcrozdw 561 3 localization localization NN cord-020235-stcrozdw 561 4 was be VBD cord-020235-stcrozdw 561 5 so so RB cord-020235-stcrozdw 561 6 far far RB cord-020235-stcrozdw 561 7 not not RB cord-020235-stcrozdw 561 8 possible possible JJ cord-020235-stcrozdw 561 9 because because IN cord-020235-stcrozdw 561 10 the the DT cord-020235-stcrozdw 561 11 recombination recombination NN cord-020235-stcrozdw 561 12 events event NNS cord-020235-stcrozdw 561 13 occured occur VBD cord-020235-stcrozdw 561 14 mainly mainly RB cord-020235-stcrozdw 561 15 in in IN cord-020235-stcrozdw 561 16 regions region NNS cord-020235-stcrozdw 561 17 near near IN cord-020235-stcrozdw 561 18 the the DT cord-020235-stcrozdw 561 19 ends end NNS cord-020235-stcrozdw 561 20 of of IN cord-020235-stcrozdw 561 21 the the DT cord-020235-stcrozdw 561 22 L L NNP cord-020235-stcrozdw 561 23 - - HYPH cord-020235-stcrozdw 561 24 DNA DNA NNP cord-020235-stcrozdw 561 25 . . . cord-020235-stcrozdw 562 1 -Furthermore -furthermore NN cord-020235-stcrozdw 562 2 recombinants recombinant NNS cord-020235-stcrozdw 562 3 were be VBD cord-020235-stcrozdw 562 4 constructed construct VBN cord-020235-stcrozdw 562 5 to to TO cord-020235-stcrozdw 562 6 identify identify VB cord-020235-stcrozdw 562 7 the the DT cord-020235-stcrozdw 562 8 genomic genomic JJ cord-020235-stcrozdw 562 9 region region NN cord-020235-stcrozdw 562 10 responsible responsible JJ cord-020235-stcrozdw 562 11 for for IN cord-020235-stcrozdw 562 12 oncogenicity oncogenicity NN cord-020235-stcrozdw 562 13 . . . cord-020235-stcrozdw 563 1 The the DT cord-020235-stcrozdw 563 2 wt wt NN cord-020235-stcrozdw 563 3 - - HYPH cord-020235-stcrozdw 563 4 strains strain NNS cord-020235-stcrozdw 563 5 of of IN cord-020235-stcrozdw 563 6 H. H. NNP cord-020235-stcrozdw 563 7 saimiri saimiri NNS cord-020235-stcrozdw 563 8 are be VBP cord-020235-stcrozdw 563 9 oncogenic oncogenic JJ cord-020235-stcrozdw 563 10 while while IN cord-020235-stcrozdw 563 11 attenuated attenuated JJ cord-020235-stcrozdw 563 12 strain strain NN cord-020235-stcrozdw 563 13 11-att 11-att CD cord-020235-stcrozdw 563 14 , , , cord-020235-stcrozdw 563 15 that that WDT cord-020235-stcrozdw 563 16 was be VBD cord-020235-stcrozdw 563 17 obtained obtain VBN cord-020235-stcrozdw 563 18 from from IN cord-020235-stcrozdw 563 19 strain strain NN cord-020235-stcrozdw 563 20 11 11 CD cord-020235-stcrozdw 563 21 has have VBZ cord-020235-stcrozdw 563 22 lost lose VBN cord-020235-stcrozdw 563 23 this this DT cord-020235-stcrozdw 563 24 property property NN cord-020235-stcrozdw 563 25 . . . cord-020235-stcrozdw 564 1 This this DT cord-020235-stcrozdw 564 2 may may MD cord-020235-stcrozdw 564 3 be be VB cord-020235-stcrozdw 564 4 due due JJ cord-020235-stcrozdw 564 5 to to IN cord-020235-stcrozdw 564 6 a a DT cord-020235-stcrozdw 564 7 deletion deletion NN cord-020235-stcrozdw 564 8 of of IN cord-020235-stcrozdw 564 9 1,1 1,1 CD cord-020235-stcrozdw 564 10 md md NNP cord-020235-stcrozdw 564 11 at at IN cord-020235-stcrozdw 564 12 the the DT cord-020235-stcrozdw 564 13 left left JJ cord-020235-stcrozdw 564 14 end end NN cord-020235-stcrozdw 564 15 of of IN cord-020235-stcrozdw 564 16 the the DT cord-020235-stcrozdw 564 17 L l NN cord-020235-stcrozdw 564 18 - - HYPH cord-020235-stcrozdw 564 19 DNA DNA NNP cord-020235-stcrozdw 564 20 . . . cord-020235-stcrozdw 565 1 Recombinants recombinant NNS cord-020235-stcrozdw 565 2 between between IN cord-020235-stcrozdw 565 3 this this DT cord-020235-stcrozdw 565 4 attenuated attenuated JJ cord-020235-stcrozdw 565 5 strain strain NN cord-020235-stcrozdw 565 6 and and CC cord-020235-stcrozdw 565 7 wt wt NN cord-020235-stcrozdw 565 8 - - HYPH cord-020235-stcrozdw 565 9 strains strain NNS cord-020235-stcrozdw 565 10 were be VBD cord-020235-stcrozdw 565 11 constructed construct VBN cord-020235-stcrozdw 565 12 . . . cord-020235-stcrozdw 566 1 The the DT cord-020235-stcrozdw 566 2 test test NN cord-020235-stcrozdw 566 3 for for IN cord-020235-stcrozdw 566 4 oncogenicity oncogenicity NN cord-020235-stcrozdw 566 5 in in IN cord-020235-stcrozdw 566 6 vivo vivo NN cord-020235-stcrozdw 566 7 is be VBZ cord-020235-stcrozdw 566 8 in in IN cord-020235-stcrozdw 566 9 progress progress NN cord-020235-stcrozdw 566 10 . . . cord-020235-stcrozdw 567 1 The the DT cord-020235-stcrozdw 567 2 T T NNP cord-020235-stcrozdw 567 3 - - HYPH cord-020235-stcrozdw 567 4 Iymphoid Iymphoid NNP cord-020235-stcrozdw 567 5 cells cell NNS cord-020235-stcrozdw 567 6 can can MD cord-020235-stcrozdw 567 7 contain contain VB cord-020235-stcrozdw 567 8 up up IN cord-020235-stcrozdw 567 9 to to TO cord-020235-stcrozdw 567 10 300 300 CD cord-020235-stcrozdw 567 11 genome genome NN cord-020235-stcrozdw 567 12 copies copy NNS cord-020235-stcrozdw 567 13 per per IN cord-020235-stcrozdw 567 14 cell cell NN cord-020235-stcrozdw 567 15 as as IN cord-020235-stcrozdw 567 16 episomes episome NNS cord-020235-stcrozdw 567 17 . . . cord-020235-stcrozdw 568 1 We -PRON- PRP cord-020235-stcrozdw 568 2 have have VBP cord-020235-stcrozdw 568 3 begun begin VBN cord-020235-stcrozdw 568 4 to to TO cord-020235-stcrozdw 568 5 study study VB cord-020235-stcrozdw 568 6 translation translation NN cord-020235-stcrozdw 568 7 and and CC cord-020235-stcrozdw 568 8 transcription transcription NN cord-020235-stcrozdw 568 9 in in IN cord-020235-stcrozdw 568 10 transformed transformed JJ cord-020235-stcrozdw 568 11 cells cell NNS cord-020235-stcrozdw 568 12 in in IN cord-020235-stcrozdw 568 13 comparison comparison NN cord-020235-stcrozdw 568 14 to to TO cord-020235-stcrozdw 568 15 lytically lytically RB cord-020235-stcrozdw 568 16 infected infect VBN cord-020235-stcrozdw 568 17 OMK OMK NNP cord-020235-stcrozdw 568 18 - - HYPH cord-020235-stcrozdw 568 19 cells cell NNS cord-020235-stcrozdw 568 20 . . . cord-020235-stcrozdw 569 1 About about RB cord-020235-stcrozdw 569 2 25 25 CD cord-020235-stcrozdw 569 3 new new JJ cord-020235-stcrozdw 569 4 proteins protein NNS cord-020235-stcrozdw 569 5 can can MD cord-020235-stcrozdw 569 6 be be VB cord-020235-stcrozdw 569 7 detected detect VBN cord-020235-stcrozdw 569 8 in in IN cord-020235-stcrozdw 569 9 lyrically lyrically RB cord-020235-stcrozdw 569 10 infected infect VBN cord-020235-stcrozdw 569 11 cells cell NNS cord-020235-stcrozdw 569 12 having have VBG cord-020235-stcrozdw 569 13 apparent apparent JJ cord-020235-stcrozdw 569 14 molecular molecular JJ cord-020235-stcrozdw 569 15 weights weight NNS cord-020235-stcrozdw 569 16 between between IN cord-020235-stcrozdw 569 17 12 12 CD cord-020235-stcrozdw 569 18 - - SYM cord-020235-stcrozdw 569 19 200 200 CD cord-020235-stcrozdw 569 20 kd kd NNS cord-020235-stcrozdw 569 21 . . . cord-020235-stcrozdw 570 1 -At -At . cord-020235-stcrozdw 571 1 early early JJ cord-020235-stcrozdw 571 2 and and CC cord-020235-stcrozdw 571 3 late late JJ cord-020235-stcrozdw 571 4 stages stage NNS cord-020235-stcrozdw 571 5 of of IN cord-020235-stcrozdw 571 6 infection infection NN cord-020235-stcrozdw 572 1 the the DT cord-020235-stcrozdw 572 2 right right JJ cord-020235-stcrozdw 572 3 part part NN cord-020235-stcrozdw 572 4 of of IN cord-020235-stcrozdw 572 5 the the DT cord-020235-stcrozdw 572 6 genome genome NN cord-020235-stcrozdw 572 7 is be VBZ cord-020235-stcrozdw 572 8 preferentially preferentially RB cord-020235-stcrozdw 572 9 transcribed transcribe VBN cord-020235-stcrozdw 572 10 and and CC cord-020235-stcrozdw 572 11 each each DT cord-020235-stcrozdw 572 12 DNA dna NN cord-020235-stcrozdw 572 13 - - HYPH cord-020235-stcrozdw 572 14 fragment fragment NN cord-020235-stcrozdw 572 15 encodes encode VBZ cord-020235-stcrozdw 572 16 a a DT cord-020235-stcrozdw 572 17 series series NN cord-020235-stcrozdw 572 18 of of IN cord-020235-stcrozdw 572 19 specific specific JJ cord-020235-stcrozdw 572 20 RNAs rna NNS cord-020235-stcrozdw 572 21 . . . cord-020235-stcrozdw 573 1 -In -In : cord-020235-stcrozdw 573 2 contrast contrast NN cord-020235-stcrozdw 573 3 , , , cord-020235-stcrozdw 573 4 we -PRON- PRP cord-020235-stcrozdw 573 5 do do VBP cord-020235-stcrozdw 573 6 not not RB cord-020235-stcrozdw 573 7 find find VB cord-020235-stcrozdw 573 8 any any DT cord-020235-stcrozdw 573 9 virus virus NN cord-020235-stcrozdw 573 10 - - HYPH cord-020235-stcrozdw 573 11 specific specific JJ cord-020235-stcrozdw 573 12 proteins protein NNS cord-020235-stcrozdw 573 13 in in IN cord-020235-stcrozdw 573 14 the the DT cord-020235-stcrozdw 573 15 transformed transformed JJ cord-020235-stcrozdw 573 16 cells cell NNS cord-020235-stcrozdw 573 17 after after IN cord-020235-stcrozdw 573 18 labeling label VBG cord-020235-stcrozdw 573 19 with with IN cord-020235-stcrozdw 573 20 3sS 3ss CD cord-020235-stcrozdw 573 21 - - HYPH cord-020235-stcrozdw 573 22 methionine methionine NN cord-020235-stcrozdw 573 23 and and CC cord-020235-stcrozdw 573 24 subsequent subsequent JJ cord-020235-stcrozdw 573 25 immunoprecipitation immunoprecipitation NN cord-020235-stcrozdw 573 26 . . . cord-020235-stcrozdw 574 1 Preliminary preliminary JJ cord-020235-stcrozdw 574 2 results result NNS cord-020235-stcrozdw 574 3 may may MD cord-020235-stcrozdw 574 4 suggest suggest VB cord-020235-stcrozdw 574 5 that that IN cord-020235-stcrozdw 574 6 the the DT cord-020235-stcrozdw 574 7 only only JJ cord-020235-stcrozdw 574 8 virus virus NN cord-020235-stcrozdw 574 9 - - HYPH cord-020235-stcrozdw 574 10 specific specific JJ cord-020235-stcrozdw 574 11 RNA RNA NNP cord-020235-stcrozdw 574 12 found find VBN cord-020235-stcrozdw 574 13 in in IN cord-020235-stcrozdw 574 14 the the DT cord-020235-stcrozdw 574 15 transformed transformed JJ cord-020235-stcrozdw 574 16 cells cell NNS cord-020235-stcrozdw 574 17 are be VBP cord-020235-stcrozdw 574 18 small small JJ cord-020235-stcrozdw 574 19 RNAs rna NNS cord-020235-stcrozdw 574 20 with with IN cord-020235-stcrozdw 574 21 molecular molecular JJ cord-020235-stcrozdw 574 22 weights weight NNS cord-020235-stcrozdw 574 23 of of IN cord-020235-stcrozdw 574 24 about about RB cord-020235-stcrozdw 574 25 0.13 0.13 CD cord-020235-stcrozdw 574 26 kb kb NNP cord-020235-stcrozdw 574 27 . . . cord-020235-stcrozdw 575 1 -A -A : cord-020235-stcrozdw 575 2 more more RBR cord-020235-stcrozdw 575 3 detailed detailed JJ cord-020235-stcrozdw 575 4 analysis analysis NN cord-020235-stcrozdw 575 5 has have VBZ cord-020235-stcrozdw 575 6 to to TO cord-020235-stcrozdw 575 7 be be VB cord-020235-stcrozdw 575 8 performed perform VBN cord-020235-stcrozdw 575 9 in in IN cord-020235-stcrozdw 575 10 order order NN cord-020235-stcrozdw 575 11 to to TO cord-020235-stcrozdw 575 12 confirm confirm VB cord-020235-stcrozdw 575 13 these these DT cord-020235-stcrozdw 575 14 hybridization hybridization NN cord-020235-stcrozdw 575 15 data datum NNS cord-020235-stcrozdw 575 16 . . . cord-020235-stcrozdw 576 1 Max Max NNP cord-020235-stcrozdw 576 2 von von NNP cord-020235-stcrozdw 576 3 Pettenkofer Pettenkofer NNP cord-020235-stcrozdw 576 4 Inst Inst NNP cord-020235-stcrozdw 576 5 . . . cord-020235-stcrozdw 577 1 , , , cord-020235-stcrozdw 577 2 D-8000 D-8000 NNP cord-020235-stcrozdw 577 3 Mi.inchen Mi.inchen NNP cord-020235-stcrozdw 577 4 2 2 CD cord-020235-stcrozdw 577 5 Characterization characterization NN cord-020235-stcrozdw 577 6 of of IN cord-020235-stcrozdw 577 7 Herpesvirus Herpesvirus NNP cord-020235-stcrozdw 577 8 saimiri saimiri NNP cord-020235-stcrozdw 577 9 Glycoproteins Glycoproteins NNP cord-020235-stcrozdw 577 10 MODROW MODROW NNP cord-020235-stcrozdw 577 11 , , , cord-020235-stcrozdw 577 12 S. S. NNP cord-020235-stcrozdw 577 13 and and CC cord-020235-stcrozdw 577 14 WOLF WOLF NNP cord-020235-stcrozdw 577 15 , , , cord-020235-stcrozdw 577 16 H. H. NNP cord-020235-stcrozdw 578 1 For for IN cord-020235-stcrozdw 578 2 the the DT cord-020235-stcrozdw 578 3 identification identification NN cord-020235-stcrozdw 578 4 of of IN cord-020235-stcrozdw 578 5 Herpesvirus Herpesvirus NNP cord-020235-stcrozdw 578 6 saimiri saimiri IN cord-020235-stcrozdw 578 7 glycoproteins glycoprotein NNS cord-020235-stcrozdw 578 8 we -PRON- PRP cord-020235-stcrozdw 578 9 seperated seperate VBD cord-020235-stcrozdw 578 10 H. H. NNP cord-020235-stcrozdw 578 11 saimiri saimiri NNP cord-020235-stcrozdw 578 12 11 11 CD cord-020235-stcrozdw 578 13 induced induce VBN cord-020235-stcrozdw 578 14 cell cell NN cord-020235-stcrozdw 578 15 proteins protein NNS cord-020235-stcrozdw 578 16 on on IN cord-020235-stcrozdw 578 17 SDS sds NN cord-020235-stcrozdw 578 18 - - HYPH cord-020235-stcrozdw 578 19 polyacrylamide polyacrylamide NN cord-020235-stcrozdw 578 20 gels gel NNS cord-020235-stcrozdw 578 21 and and CC cord-020235-stcrozdw 578 22 transfered transfer VBD cord-020235-stcrozdw 578 23 the the DT cord-020235-stcrozdw 578 24 polypeptides polypeptide NNS cord-020235-stcrozdw 578 25 by by IN cord-020235-stcrozdw 578 26 elec elec JJ cord-020235-stcrozdw 578 27 - - HYPH cord-020235-stcrozdw 578 28 trophoretic trophoretic JJ cord-020235-stcrozdw 578 29 blotting blotting NN cord-020235-stcrozdw 578 30 ( ( -LRB- cord-020235-stcrozdw 578 31 2 2 CD cord-020235-stcrozdw 578 32 h h NN cord-020235-stcrozdw 578 33 , , , cord-020235-stcrozdw 578 34 3,7 3,7 NNP cord-020235-stcrozdw 578 35 mA mA NNP cord-020235-stcrozdw 578 36 / / SYM cord-020235-stcrozdw 578 37 cm cm NNP cord-020235-stcrozdw 578 38 2 2 CD cord-020235-stcrozdw 578 39 ) ) -RRB- cord-020235-stcrozdw 578 40 to to IN cord-020235-stcrozdw 578 41 nitrocellulose nitrocellulose NN cord-020235-stcrozdw 578 42 paper paper NN cord-020235-stcrozdw 578 43 using use VBG cord-020235-stcrozdw 578 44 carbon carbon NN cord-020235-stcrozdw 578 45 electrodes electrode NNS cord-020235-stcrozdw 578 46 and and CC cord-020235-stcrozdw 578 47 buffer buffer VB cord-020235-stcrozdw 578 48 soaked soak VBN cord-020235-stcrozdw 578 49 sponge sponge NN cord-020235-stcrozdw 578 50 to to TO cord-020235-stcrozdw 578 51 cover cover VB cord-020235-stcrozdw 578 52 the the DT cord-020235-stcrozdw 578 53 gel gel NN cord-020235-stcrozdw 578 54 / / SYM cord-020235-stcrozdw 578 55 filter filter NN cord-020235-stcrozdw 578 56 layer layer NN cord-020235-stcrozdw 578 57 . . . cord-020235-stcrozdw 579 1 Lectins Lectins NNP cord-020235-stcrozdw 579 2 , , , cord-020235-stcrozdw 579 3 which which WDT cord-020235-stcrozdw 579 4 are be VBP cord-020235-stcrozdw 579 5 known know VBN cord-020235-stcrozdw 579 6 to to TO cord-020235-stcrozdw 579 7 bind bind VB cord-020235-stcrozdw 579 8 very very RB cord-020235-stcrozdw 579 9 specifically specifically RB cord-020235-stcrozdw 579 10 to to IN cord-020235-stcrozdw 579 11 certain certain JJ cord-020235-stcrozdw 579 12 sugar sugar NN cord-020235-stcrozdw 579 13 residues residue NNS cord-020235-stcrozdw 579 14 ( ( -LRB- cord-020235-stcrozdw 579 15 Concanavalin Concanavalin NNP cord-020235-stcrozdw 579 16 A A NNP cord-020235-stcrozdw 579 17 to to IN cord-020235-stcrozdw 579 18 D d NN cord-020235-stcrozdw 579 19 - - HYPH cord-020235-stcrozdw 579 20 glucose glucose NN cord-020235-stcrozdw 579 21 and and CC cord-020235-stcrozdw 579 22 D d NN cord-020235-stcrozdw 579 23 - - HYPH cord-020235-stcrozdw 579 24 mannose mannose JJ cord-020235-stcrozdw 579 25 derivates derivate NNS cord-020235-stcrozdw 579 26 , , , cord-020235-stcrozdw 579 27 Soy soy NN cord-020235-stcrozdw 579 28 bean bean NN cord-020235-stcrozdw 579 29 agglutinin agglutinin NNS cord-020235-stcrozdw 579 30 to to IN cord-020235-stcrozdw 579 31 N N NNP cord-020235-stcrozdw 579 32 - - HYPH cord-020235-stcrozdw 579 33 acetyl acetyl NN cord-020235-stcrozdw 579 34 - - HYPH cord-020235-stcrozdw 579 35 D d NN cord-020235-stcrozdw 579 36 - - HYPH cord-020235-stcrozdw 579 37 galactosamine galactosamine NN cord-020235-stcrozdw 579 38 and and CC cord-020235-stcrozdw 579 39 D d NN cord-020235-stcrozdw 579 40 - - HYPH cord-020235-stcrozdw 579 41 galactose galactose NN cord-020235-stcrozdw 579 42 , , , cord-020235-stcrozdw 579 43 Dolichos Dolichos NNP cord-020235-stcrozdw 579 44 biflorus biflorus NNP cord-020235-stcrozdw 579 45 agglutinin agglutinin NNS cord-020235-stcrozdw 579 46 to to IN cord-020235-stcrozdw 579 47 N N NNP cord-020235-stcrozdw 579 48 - - HYPH cord-020235-stcrozdw 579 49 acetyl acetyl NN cord-020235-stcrozdw 579 50 - - HYPH cord-020235-stcrozdw 579 51 D d NN cord-020235-stcrozdw 579 52 - - HYPH cord-020235-stcrozdw 579 53 galactosamine galactosamine NN cord-020235-stcrozdw 579 54 , , , cord-020235-stcrozdw 579 55 Ulex Ulex NNP cord-020235-stcrozdw 579 56 europaeus europaeus NN cord-020235-stcrozdw 579 57 agglutinin agglutinin VBZ cord-020235-stcrozdw 579 58 to to IN cord-020235-stcrozdw 579 59 L L NNP cord-020235-stcrozdw 579 60 - - HYPH cord-020235-stcrozdw 579 61 fucose fucose NNP cord-020235-stcrozdw 579 62 ) ) -RRB- cord-020235-stcrozdw 579 63 were be VBD cord-020235-stcrozdw 579 64 iodinated iodinate VBN cord-020235-stcrozdw 579 65 using use VBG cord-020235-stcrozdw 579 66 the the DT cord-020235-stcrozdw 579 67 NEN NEN NNP cord-020235-stcrozdw 579 68 - - HYPH cord-020235-stcrozdw 579 69 Iactoperoxidase Iactoperoxidase NNP cord-020235-stcrozdw 579 70 system system NN cord-020235-stcrozdw 579 71 . . . cord-020235-stcrozdw 580 1 The the DT cord-020235-stcrozdw 580 2 glycoproteins glycoprotein NNS cord-020235-stcrozdw 580 3 bound bind VBN cord-020235-stcrozdw 580 4 to to IN cord-020235-stcrozdw 580 5 the the DT cord-020235-stcrozdw 580 6 nitrocellulose nitrocellulose NN cord-020235-stcrozdw 580 7 sheets sheet NNS cord-020235-stcrozdw 580 8 were be VBD cord-020235-stcrozdw 580 9 detected detect VBN cord-020235-stcrozdw 580 10 by by IN cord-020235-stcrozdw 580 11 incubation incubation NN cord-020235-stcrozdw 580 12 with with IN cord-020235-stcrozdw 580 13 the the DT cord-020235-stcrozdw 580 14 1Z5J 1z5j CD cord-020235-stcrozdw 580 15 - - HYPH cord-020235-stcrozdw 580 16 labelled label VBN cord-020235-stcrozdw 580 17 lectins lectin NNS cord-020235-stcrozdw 580 18 . . . cord-020235-stcrozdw 581 1 By by IN cord-020235-stcrozdw 581 2 this this DT cord-020235-stcrozdw 581 3 , , , cord-020235-stcrozdw 581 4 eight eight CD cord-020235-stcrozdw 581 5 viral viral JJ cord-020235-stcrozdw 581 6 glycoproteins glycoprotein NNS cord-020235-stcrozdw 581 7 could could MD cord-020235-stcrozdw 581 8 be be VB cord-020235-stcrozdw 581 9 identified identify VBN cord-020235-stcrozdw 581 10 , , , cord-020235-stcrozdw 581 11 two two CD cord-020235-stcrozdw 581 12 of of IN cord-020235-stcrozdw 581 13 them -PRON- PRP cord-020235-stcrozdw 581 14 were be VBD cord-020235-stcrozdw 581 15 synthesized synthesize VBN cord-020235-stcrozdw 581 16 in in IN cord-020235-stcrozdw 581 17 the the DT cord-020235-stcrozdw 581 18 presence presence NN cord-020235-stcrozdw 581 19 of of IN cord-020235-stcrozdw 581 20 canavanine canavanine NNP cord-020235-stcrozdw 581 21 , , , cord-020235-stcrozdw 581 22 and and CC cord-020235-stcrozdw 581 23 characterized characterize VBD cord-020235-stcrozdw 581 24 according accord VBG cord-020235-stcrozdw 581 25 to to IN cord-020235-stcrozdw 581 26 the the DT cord-020235-stcrozdw 581 27 type type NN cord-020235-stcrozdw 581 28 of of IN cord-020235-stcrozdw 581 29 glycosylation glycosylation NN cord-020235-stcrozdw 581 30 . . . cord-020235-stcrozdw 582 1 Lymphocystis Lymphocystis NNP cord-020235-stcrozdw 582 2 disease disease NN cord-020235-stcrozdw 582 3 ( ( -LRB- cord-020235-stcrozdw 582 4 LD LD NNP cord-020235-stcrozdw 582 5 ) ) -RRB- cord-020235-stcrozdw 582 6 is be VBZ cord-020235-stcrozdw 582 7 a a DT cord-020235-stcrozdw 582 8 virus virus NN cord-020235-stcrozdw 582 9 disease disease NN cord-020235-stcrozdw 582 10 of of IN cord-020235-stcrozdw 582 11 marine marine JJ cord-020235-stcrozdw 582 12 fish fish NN cord-020235-stcrozdw 582 13 with with IN cord-020235-stcrozdw 582 14 an an DT cord-020235-stcrozdw 582 15 almost almost RB cord-020235-stcrozdw 582 16 world world NN cord-020235-stcrozdw 582 17 - - HYPH cord-020235-stcrozdw 582 18 wide wide JJ cord-020235-stcrozdw 582 19 geographical geographical JJ cord-020235-stcrozdw 582 20 distribution distribution NN cord-020235-stcrozdw 582 21 . . . cord-020235-stcrozdw 583 1 This this DT cord-020235-stcrozdw 583 2 disease disease NN cord-020235-stcrozdw 583 3 is be VBZ cord-020235-stcrozdw 583 4 characterised characterise VBN cord-020235-stcrozdw 583 5 by by IN cord-020235-stcrozdw 583 6 papilloma papilloma NN cord-020235-stcrozdw 583 7 - - HYPH cord-020235-stcrozdw 583 8 like like JJ cord-020235-stcrozdw 583 9 tumour tumour NN cord-020235-stcrozdw 583 10 lesions lesion NNS cord-020235-stcrozdw 583 11 . . . cord-020235-stcrozdw 584 1 Lymphocystis Lymphocystis NNP cord-020235-stcrozdw 584 2 disease disease NN cord-020235-stcrozdw 584 3 virus virus NN cord-020235-stcrozdw 584 4 ( ( -LRB- cord-020235-stcrozdw 584 5 FDLV FDLV NNP cord-020235-stcrozdw 584 6 ) ) -RRB- cord-020235-stcrozdw 584 7 has have VBZ cord-020235-stcrozdw 584 8 been be VBN cord-020235-stcrozdw 584 9 tentatively tentatively RB cord-020235-stcrozdw 584 10 classified classify VBN cord-020235-stcrozdw 584 11 as as IN cord-020235-stcrozdw 584 12 belonging belong VBG cord-020235-stcrozdw 584 13 to to IN cord-020235-stcrozdw 584 14 the the DT cord-020235-stcrozdw 584 15 family family NN cord-020235-stcrozdw 584 16 of of IN cord-020235-stcrozdw 584 17 Iridoviridae Iridoviridae NNP cord-020235-stcrozdw 584 18 . . . cord-020235-stcrozdw 585 1 This this DT cord-020235-stcrozdw 585 2 report report NN cord-020235-stcrozdw 585 3 describes describe VBZ cord-020235-stcrozdw 585 4 the the DT cord-020235-stcrozdw 585 5 anatomy anatomy NN cord-020235-stcrozdw 585 6 of of IN cord-020235-stcrozdw 585 7 FDLV FDLV NNP cord-020235-stcrozdw 585 8 : : : cord-020235-stcrozdw 586 1 The the DT cord-020235-stcrozdw 586 2 FDLV FDLV NNP cord-020235-stcrozdw 586 3 virions virion NNS cord-020235-stcrozdw 586 4 were be VBD cord-020235-stcrozdw 586 5 isolated isolate VBN cord-020235-stcrozdw 586 6 from from IN cord-020235-stcrozdw 586 7 a a DT cord-020235-stcrozdw 586 8 total total NN cord-020235-stcrozdw 586 9 of of IN cord-020235-stcrozdw 586 10 22 22 CD cord-020235-stcrozdw 586 11 fish fish NN cord-020235-stcrozdw 586 12 with with IN cord-020235-stcrozdw 586 13 LD LD NNP cord-020235-stcrozdw 586 14 lesions lesion NNS cord-020235-stcrozdw 586 15 , , , cord-020235-stcrozdw 586 16 caught catch VBN cord-020235-stcrozdw 586 17 near near IN cord-020235-stcrozdw 586 18 the the DT cord-020235-stcrozdw 586 19 Doggerbank Doggerbank NNP cord-020235-stcrozdw 586 20 , , , cord-020235-stcrozdw 586 21 including include VBG cord-020235-stcrozdw 586 22 12 12 CD cord-020235-stcrozdw 586 23 flounders flounder NNS cord-020235-stcrozdw 586 24 , , , cord-020235-stcrozdw 586 25 6 6 CD cord-020235-stcrozdw 586 26 dabs dab NNS cord-020235-stcrozdw 586 27 , , , cord-020235-stcrozdw 586 28 and and CC cord-020235-stcrozdw 586 29 4 4 CD cord-020235-stcrozdw 586 30 plaice plaice NN cord-020235-stcrozdw 586 31 , , , cord-020235-stcrozdw 586 32 which which WDT cord-020235-stcrozdw 586 33 were be VBD cord-020235-stcrozdw 586 34 analysed analyse VBN cord-020235-stcrozdw 586 35 individually individually RB cord-020235-stcrozdw 586 36 . . . cord-020235-stcrozdw 587 1 The the DT cord-020235-stcrozdw 587 2 purity purity NN cord-020235-stcrozdw 587 3 of of IN cord-020235-stcrozdw 587 4 the the DT cord-020235-stcrozdw 587 5 virus virus NN cord-020235-stcrozdw 587 6 preparations preparation NNS cord-020235-stcrozdw 587 7 was be VBD cord-020235-stcrozdw 587 8 examined examine VBN cord-020235-stcrozdw 587 9 by by IN cord-020235-stcrozdw 587 10 a a DT cord-020235-stcrozdw 587 11 negative negative JJ cord-020235-stcrozdw 587 12 - - HYPH cord-020235-stcrozdw 587 13 staining stain VBG cord-020235-stcrozdw 587 14 technique technique NN cord-020235-stcrozdw 587 15 and and CC cord-020235-stcrozdw 587 16 the the DT cord-020235-stcrozdw 587 17 virion virion NN cord-020235-stcrozdw 587 18 diameters diameter NNS cord-020235-stcrozdw 587 19 were be VBD cord-020235-stcrozdw 587 20 determined determine VBN cord-020235-stcrozdw 587 21 : : : cord-020235-stcrozdw 587 22 flounder flounder VB cord-020235-stcrozdw 587 23 227.5 227.5 CD cord-020235-stcrozdw 587 24 ± ± CD cord-020235-stcrozdw 587 25 12.5 12.5 CD cord-020235-stcrozdw 587 26 nm nm NN cord-020235-stcrozdw 587 27 , , , cord-020235-stcrozdw 587 28 LDV LDV NNP cord-020235-stcrozdw 587 29 - - HYPH cord-020235-stcrozdw 587 30 plaice plaice NN cord-020235-stcrozdw 587 31 198.8 198.8 CD cord-020235-stcrozdw 587 32 ± ± CD cord-020235-stcrozdw 587 33 12.9 12.9 CD cord-020235-stcrozdw 587 34 nm nm NN cord-020235-stcrozdw 587 35 , , , cord-020235-stcrozdw 587 36 and and CC cord-020235-stcrozdw 587 37 LDV LDV NNP cord-020235-stcrozdw 587 38 - - HYPH cord-020235-stcrozdw 587 39 dab dab NNP cord-020235-stcrozdw 587 40 200.5 200.5 CD cord-020235-stcrozdw 587 41 ± ± CD cord-020235-stcrozdw 587 42 12 12 CD cord-020235-stcrozdw 587 43 nm nm NN cord-020235-stcrozdw 587 44 . . . cord-020235-stcrozdw 588 1 DNAs dna NNS cord-020235-stcrozdw 588 2 of of IN cord-020235-stcrozdw 588 3 these these DT cord-020235-stcrozdw 588 4 different different JJ cord-020235-stcrozdw 588 5 LDV LDV NNP cord-020235-stcrozdw 588 6 isolates isolate NNS cord-020235-stcrozdw 588 7 were be VBD cord-020235-stcrozdw 588 8 cleaved cleave VBN cord-020235-stcrozdw 588 9 with with IN cord-020235-stcrozdw 588 10 different different JJ cord-020235-stcrozdw 588 11 restriction restriction NN cord-020235-stcrozdw 588 12 endonucleases endonuclease NNS cord-020235-stcrozdw 588 13 and and CC cord-020235-stcrozdw 588 14 the the DT cord-020235-stcrozdw 588 15 resulting result VBG cord-020235-stcrozdw 588 16 DNA dna NN cord-020235-stcrozdw 588 17 fragments fragment NNS cord-020235-stcrozdw 588 18 were be VBD cord-020235-stcrozdw 588 19 separated separate VBN cord-020235-stcrozdw 588 20 electrophoretically electrophoretically RB cord-020235-stcrozdw 588 21 on on IN cord-020235-stcrozdw 588 22 agarose agarose JJ cord-020235-stcrozdw 588 23 slab slab NN cord-020235-stcrozdw 588 24 gels gel NNS cord-020235-stcrozdw 588 25 . . . cord-020235-stcrozdw 589 1 The the DT cord-020235-stcrozdw 589 2 fragment fragment NN cord-020235-stcrozdw 589 3 patterns pattern NNS cord-020235-stcrozdw 589 4 demonstrate demonstrate VBP cord-020235-stcrozdw 589 5 that that IN cord-020235-stcrozdw 589 6 LDV LDV NNP cord-020235-stcrozdw 589 7 DNA DNA NNP cord-020235-stcrozdw 589 8 of of IN cord-020235-stcrozdw 589 9 flonders flonder NNS cord-020235-stcrozdw 589 10 and and CC cord-020235-stcrozdw 589 11 of of IN cord-020235-stcrozdw 589 12 plaice plaice NN cord-020235-stcrozdw 589 13 are be VBP cord-020235-stcrozdw 589 14 indistinguishable indistinguishable JJ cord-020235-stcrozdw 589 15 , , , cord-020235-stcrozdw 589 16 but but CC cord-020235-stcrozdw 589 17 clearly clearly RB cord-020235-stcrozdw 589 18 different different JJ cord-020235-stcrozdw 589 19 from from IN cord-020235-stcrozdw 589 20 those those DT cord-020235-stcrozdw 589 21 of of IN cord-020235-stcrozdw 589 22 dab dab NN cord-020235-stcrozdw 589 23 . . . cord-020235-stcrozdw 590 1 The the DT cord-020235-stcrozdw 590 2 determination determination NN cord-020235-stcrozdw 590 3 of of IN cord-020235-stcrozdw 590 4 the the DT cord-020235-stcrozdw 590 5 molecular molecular JJ cord-020235-stcrozdw 590 6 weights weight NNS cord-020235-stcrozdw 590 7 of of IN cord-020235-stcrozdw 590 8 FDLV FDLV NNP cord-020235-stcrozdw 590 9 DNAs dna NNS cord-020235-stcrozdw 590 10 using use VBG cord-020235-stcrozdw 590 11 contour contour NN cord-020235-stcrozdw 590 12 length length NN cord-020235-stcrozdw 590 13 measurements measurement NNS cord-020235-stcrozdw 590 14 by by IN cord-020235-stcrozdw 590 15 electron electron NN cord-020235-stcrozdw 590 16 microscopy microscopy NNS cord-020235-stcrozdw 590 17 resulted result VBN cord-020235-stcrozdw 590 18 in in IN cord-020235-stcrozdw 590 19 a a DT cord-020235-stcrozdw 590 20 value value NN cord-020235-stcrozdw 590 21 ranging range VBG cord-020235-stcrozdw 590 22 from from IN cord-020235-stcrozdw 590 23 60 60 CD cord-020235-stcrozdw 590 24 to to TO cord-020235-stcrozdw 590 25 150 150 CD cord-020235-stcrozdw 590 26 X x NN cord-020235-stcrozdw 590 27 10 10 CD cord-020235-stcrozdw 590 28 6 6 CD cord-020235-stcrozdw 590 29 daltons dalton NNS cord-020235-stcrozdw 590 30 . . . cord-020235-stcrozdw 591 1 In in IN cord-020235-stcrozdw 591 2 contrast contrast NN cord-020235-stcrozdw 591 3 the the DT cord-020235-stcrozdw 591 4 molecular molecular JJ cord-020235-stcrozdw 591 5 weight weight NN cord-020235-stcrozdw 591 6 estimations estimation NNS cord-020235-stcrozdw 591 7 by by IN cord-020235-stcrozdw 591 8 restriction restriction NN cord-020235-stcrozdw 591 9 enzyme enzyme NN cord-020235-stcrozdw 591 10 analysis analysis NN cord-020235-stcrozdw 591 11 resulted result VBD cord-020235-stcrozdw 591 12 in in IN cord-020235-stcrozdw 591 13 lower low JJR cord-020235-stcrozdw 591 14 values value NNS cord-020235-stcrozdw 591 15 ranging range VBG cord-020235-stcrozdw 591 16 from from IN cord-020235-stcrozdw 591 17 60 60 CD cord-020235-stcrozdw 591 18 to to TO cord-020235-stcrozdw 591 19 90 90 CD cord-020235-stcrozdw 591 20 X x NN cord-020235-stcrozdw 591 21 10 10 CD cord-020235-stcrozdw 591 22 6 6 CD cord-020235-stcrozdw 591 23 daltons dalton NNS cord-020235-stcrozdw 591 24 . . . cord-020235-stcrozdw 592 1 This this DT cord-020235-stcrozdw 592 2 discrepancy discrepancy NN cord-020235-stcrozdw 592 3 is be VBZ cord-020235-stcrozdw 592 4 probably probably RB cord-020235-stcrozdw 592 5 due due JJ cord-020235-stcrozdw 592 6 to to IN cord-020235-stcrozdw 592 7 a a DT cord-020235-stcrozdw 592 8 restricted restrict VBN cord-020235-stcrozdw 592 9 , , , cord-020235-stcrozdw 592 10 permutated permutated JJ cord-020235-stcrozdw 592 11 structure structure NN cord-020235-stcrozdw 592 12 of of IN cord-020235-stcrozdw 592 13 the the DT cord-020235-stcrozdw 592 14 LDV LDV NNP cord-020235-stcrozdw 592 15 genome genome NN cord-020235-stcrozdw 592 16 similar similar JJ cord-020235-stcrozdw 592 17 to to IN cord-020235-stcrozdw 592 18 the the DT cord-020235-stcrozdw 592 19 genome genome NN cord-020235-stcrozdw 592 20 of of IN cord-020235-stcrozdw 592 21 frog frog NN cord-020235-stcrozdw 592 22 virus virus NN cord-020235-stcrozdw 592 23 3 3 CD cord-020235-stcrozdw 592 24 as as IN cord-020235-stcrozdw 592 25 reported report VBN cord-020235-stcrozdw 592 26 by by IN cord-020235-stcrozdw 592 27 Granoff Granoff NNP cord-020235-stcrozdw 592 28 . . . cord-020235-stcrozdw 593 1 The the DT cord-020235-stcrozdw 593 2 structure structure NN cord-020235-stcrozdw 593 3 of of IN cord-020235-stcrozdw 593 4 FLDV FLDV NNP cord-020235-stcrozdw 593 5 constituents constituent NNS cord-020235-stcrozdw 593 6 and and CC cord-020235-stcrozdw 593 7 its -PRON- PRP$ cord-020235-stcrozdw 593 8 interaction interaction NN cord-020235-stcrozdw 593 9 with with IN cord-020235-stcrozdw 593 10 host host NN cord-020235-stcrozdw 593 11 cells cell NNS cord-020235-stcrozdw 593 12 remains remain VBZ cord-020235-stcrozdw 593 13 obscure obscure JJ cord-020235-stcrozdw 593 14 . . . cord-020235-stcrozdw 594 1 In in IN cord-020235-stcrozdw 594 2 an an DT cord-020235-stcrozdw 594 3 effort effort NN cord-020235-stcrozdw 594 4 to to TO cord-020235-stcrozdw 594 5 clarify clarify VB cord-020235-stcrozdw 594 6 the the DT cord-020235-stcrozdw 594 7 viral viral JJ cord-020235-stcrozdw 594 8 components component NNS cord-020235-stcrozdw 594 9 and and CC cord-020235-stcrozdw 594 10 their -PRON- PRP$ cord-020235-stcrozdw 594 11 functions function NNS cord-020235-stcrozdw 594 12 we -PRON- PRP cord-020235-stcrozdw 594 13 have have VBP cord-020235-stcrozdw 594 14 studied study VBN cord-020235-stcrozdw 594 15 the the DT cord-020235-stcrozdw 594 16 proteins protein NNS cord-020235-stcrozdw 594 17 and and CC cord-020235-stcrozdw 594 18 purified purify VBN cord-020235-stcrozdw 594 19 FLDV FLDV NNP cord-020235-stcrozdw 594 20 and and CC cord-020235-stcrozdw 594 21 searched search VBD cord-020235-stcrozdw 594 22 for for IN cord-020235-stcrozdw 594 23 virion virion NN cord-020235-stcrozdw 594 24 - - HYPH cord-020235-stcrozdw 594 25 associated associate VBN cord-020235-stcrozdw 594 26 enzymes enzyme NNS cord-020235-stcrozdw 594 27 . . . cord-020235-stcrozdw 595 1 -At -At : cord-020235-stcrozdw 595 2 least least JJS cord-020235-stcrozdw 595 3 33 33 CD cord-020235-stcrozdw 595 4 distinct distinct JJ cord-020235-stcrozdw 595 5 viral viral JJ cord-020235-stcrozdw 595 6 polypeptides polypeptide NNS cord-020235-stcrozdw 595 7 were be VBD cord-020235-stcrozdw 595 8 detected detect VBN cord-020235-stcrozdw 595 9 by by IN cord-020235-stcrozdw 595 10 polyacrylamide polyacrylamide NN cord-020235-stcrozdw 595 11 gel gel NN cord-020235-stcrozdw 595 12 electrophoresis electrophoresis NN cord-020235-stcrozdw 595 13 under under IN cord-020235-stcrozdw 595 14 denaturing denaturing JJ cord-020235-stcrozdw 595 15 conditions condition NNS cord-020235-stcrozdw 595 16 . . . cord-020235-stcrozdw 596 1 The the DT cord-020235-stcrozdw 596 2 polypeptide polypeptide NN cord-020235-stcrozdw 596 3 patterns pattern NNS cord-020235-stcrozdw 596 4 are be VBP cord-020235-stcrozdw 596 5 remarkably remarkably RB cord-020235-stcrozdw 596 6 specific specific JJ cord-020235-stcrozdw 596 7 for for IN cord-020235-stcrozdw 596 8 a a DT cord-020235-stcrozdw 596 9 given give VBN cord-020235-stcrozdw 596 10 fish fish NN cord-020235-stcrozdw 596 11 species specie NNS cord-020235-stcrozdw 596 12 ( ( -LRB- cord-020235-stcrozdw 596 13 flounder flounder NN cord-020235-stcrozdw 596 14 , , , cord-020235-stcrozdw 596 15 plaice plaice NN cord-020235-stcrozdw 596 16 , , , cord-020235-stcrozdw 596 17 and and CC cord-020235-stcrozdw 596 18 dab dab NN cord-020235-stcrozdw 596 19 ) ) -RRB- cord-020235-stcrozdw 596 20 although although IN cord-020235-stcrozdw 596 21 some some DT cord-020235-stcrozdw 596 22 heterogeneity heterogeneity NN cord-020235-stcrozdw 596 23 was be VBD cord-020235-stcrozdw 596 24 found find VBN cord-020235-stcrozdw 596 25 when when WRB cord-020235-stcrozdw 596 26 proteins protein NNS cord-020235-stcrozdw 596 27 of of IN cord-020235-stcrozdw 596 28 individual individual JJ cord-020235-stcrozdw 596 29 fish fish NN cord-020235-stcrozdw 596 30 of of IN cord-020235-stcrozdw 596 31 the the DT cord-020235-stcrozdw 596 32 same same JJ cord-020235-stcrozdw 596 33 species specie NNS cord-020235-stcrozdw 596 34 were be VBD cord-020235-stcrozdw 596 35 analysed analyse VBN cord-020235-stcrozdw 596 36 . . . cord-020235-stcrozdw 597 1 -It -It : cord-020235-stcrozdw 597 2 was be VBD cord-020235-stcrozdw 597 3 found find VBN cord-020235-stcrozdw 597 4 that that IN cord-020235-stcrozdw 597 5 a a DT cord-020235-stcrozdw 597 6 nucleoside nucleoside NN cord-020235-stcrozdw 597 7 triphosphate triphosphate NN cord-020235-stcrozdw 597 8 phosphohydrolase phosphohydrolase NN cord-020235-stcrozdw 597 9 activity activity NN cord-020235-stcrozdw 597 10 is be VBZ cord-020235-stcrozdw 597 11 closely closely RB cord-020235-stcrozdw 597 12 associated associate VBN cord-020235-stcrozdw 597 13 with with IN cord-020235-stcrozdw 597 14 FLDV FLDV NNP cord-020235-stcrozdw 597 15 particles particle NNS cord-020235-stcrozdw 597 16 . . . cord-020235-stcrozdw 598 1 This this DT cord-020235-stcrozdw 598 2 activity activity NN cord-020235-stcrozdw 598 3 hydrolyses hydrolyse VBZ cord-020235-stcrozdw 598 4 ATP ATP NNP cord-020235-stcrozdw 598 5 with with IN cord-020235-stcrozdw 598 6 a a DT cord-020235-stcrozdw 598 7 high high JJ cord-020235-stcrozdw 598 8 preference preference NN cord-020235-stcrozdw 598 9 . . . cord-020235-stcrozdw 599 1 The the DT cord-020235-stcrozdw 599 2 reaction reaction NN cord-020235-stcrozdw 599 3 requires require VBZ cord-020235-stcrozdw 599 4 a a DT cord-020235-stcrozdw 599 5 non non JJ cord-020235-stcrozdw 599 6 - - JJ cord-020235-stcrozdw 599 7 ionic ionic JJ cord-020235-stcrozdw 599 8 detergent detergent NN cord-020235-stcrozdw 599 9 and and CC cord-020235-stcrozdw 599 10 a a DT cord-020235-stcrozdw 599 11 divalent divalent JJ cord-020235-stcrozdw 599 12 cation cation NN cord-020235-stcrozdw 599 13 , , , cord-020235-stcrozdw 599 14 such such JJ cord-020235-stcrozdw 599 15 as as IN cord-020235-stcrozdw 599 16 Mg2 mg2 CD cord-020235-stcrozdw 599 17 + + CC cord-020235-stcrozdw 599 18 . . . cord-020235-stcrozdw 600 1 Reaction reaction NN cord-020235-stcrozdw 600 2 rates rate NNS cord-020235-stcrozdw 600 3 and and CC cord-020235-stcrozdw 600 4 substrate substrate NN cord-020235-stcrozdw 600 5 specifities specifitie NNS cord-020235-stcrozdw 600 6 were be VBD cord-020235-stcrozdw 600 7 determined determine VBN cord-020235-stcrozdw 600 8 . . . cord-020235-stcrozdw 601 1 The the DT cord-020235-stcrozdw 601 2 products product NNS cord-020235-stcrozdw 601 3 of of IN cord-020235-stcrozdw 601 4 the the DT cord-020235-stcrozdw 601 5 reaction reaction NN cord-020235-stcrozdw 601 6 are be VBP cord-020235-stcrozdw 601 7 nucleosides nucleoside NNS cord-020235-stcrozdw 601 8 disphophares disphophare NNS cord-020235-stcrozdw 601 9 and and CC cord-020235-stcrozdw 601 10 inorganic inorganic JJ cord-020235-stcrozdw 601 11 phosphate phosphate NN cord-020235-stcrozdw 601 12 . . . cord-020235-stcrozdw 602 1 Characterization characterization NN cord-020235-stcrozdw 602 2 of of IN cord-020235-stcrozdw 602 3 a a DT cord-020235-stcrozdw 602 4 Poxvirus Poxvirus NNP cord-020235-stcrozdw 602 5 Isolated Isolated NNP cord-020235-stcrozdw 602 6 from from IN cord-020235-stcrozdw 602 7 White White NNP cord-020235-stcrozdw 602 8 Rhinoceros Rhinoceros NNP cord-020235-stcrozdw 602 9 ( ( -LRB- cord-020235-stcrozdw 602 10 Ceratotherium Ceratotherium NNP cord-020235-stcrozdw 602 11 s. s. NNP cord-020235-stcrozdw 602 12 simum simum NNP cord-020235-stcrozdw 602 13 ) ) -RRB- cord-020235-stcrozdw 602 14 PILASKI PILASKI NNP cord-020235-stcrozdw 602 15 , , , cord-020235-stcrozdw 602 16 ] ] -RRB- cord-020235-stcrozdw 602 17 . . . cord-020235-stcrozdw 603 1 , , , cord-020235-stcrozdw 603 2 SCHALLER SCHALLER NNP cord-020235-stcrozdw 603 3 , , , cord-020235-stcrozdw 603 4 K. K. NNP cord-020235-stcrozdw 603 5 , , , cord-020235-stcrozdw 603 6 OLBERDING OLBERDING NNP cord-020235-stcrozdw 603 7 , , , cord-020235-stcrozdw 603 8 P. P. NNP cord-020235-stcrozdw 603 9 , , , cord-020235-stcrozdw 603 10 and and CC cord-020235-stcrozdw 603 11 FINKE FINKE NNP cord-020235-stcrozdw 603 12 , , , cord-020235-stcrozdw 603 13 HANNELORE HANNELORE NNP cord-020235-stcrozdw 604 1 In in IN cord-020235-stcrozdw 604 2 September September NNP cord-020235-stcrozdw 604 3 1977 1977 CD cord-020235-stcrozdw 604 4 an an DT cord-020235-stcrozdw 604 5 outbreak outbreak NN cord-020235-stcrozdw 604 6 of of IN cord-020235-stcrozdw 604 7 poxdisease poxdisease NN cord-020235-stcrozdw 604 8 occurred occur VBD cord-020235-stcrozdw 604 9 in in IN cord-020235-stcrozdw 604 10 White White NNP cord-020235-stcrozdw 604 11 Rhinoceroses Rhinoceroses NNPS cord-020235-stcrozdw 604 12 ( ( -LRB- cord-020235-stcrozdw 604 13 Ceratotherium Ceratotherium NNP cord-020235-stcrozdw 604 14 s. s. NNP cord-020235-stcrozdw 604 15 simum simum NNP cord-020235-stcrozdw 604 16 ) ) -RRB- cord-020235-stcrozdw 604 17 in in IN cord-020235-stcrozdw 604 18 the the DT cord-020235-stcrozdw 604 19 Munster Munster NNP cord-020235-stcrozdw 604 20 zoo zoo NN cord-020235-stcrozdw 604 21 . . . cord-020235-stcrozdw 605 1 At at IN cord-020235-stcrozdw 605 2 the the DT cord-020235-stcrozdw 605 3 same same JJ cord-020235-stcrozdw 605 4 time time NN cord-020235-stcrozdw 605 5 a a DT cord-020235-stcrozdw 605 6 similar similar JJ cord-020235-stcrozdw 605 7 outbreak outbreak NN cord-020235-stcrozdw 605 8 was be VBD cord-020235-stcrozdw 605 9 observed observe VBN cord-020235-stcrozdw 605 10 in in IN cord-020235-stcrozdw 605 11 elephants elephant NNS cord-020235-stcrozdw 605 12 ( ( -LRB- cord-020235-stcrozdw 605 13 Elephas Elephas NNP cord-020235-stcrozdw 605 14 maximus maximus NNP cord-020235-stcrozdw 605 15 , , , cord-020235-stcrozdw 605 16 Loxodonta Loxodonta NNP cord-020235-stcrozdw 605 17 africana africana NN cord-020235-stcrozdw 605 18 ) ) -RRB- cord-020235-stcrozdw 605 19 of of IN cord-020235-stcrozdw 605 20 the the DT cord-020235-stcrozdw 605 21 zoo zoo NN cord-020235-stcrozdw 605 22 in in IN cord-020235-stcrozdw 605 23 Frankfurt Frankfurt NNP cord-020235-stcrozdw 605 24 ( ( -LRB- cord-020235-stcrozdw 605 25 airline airline NN cord-020235-stcrozdw 605 26 distance distance NN cord-020235-stcrozdw 605 27 about about RB cord-020235-stcrozdw 605 28 230 230 CD cord-020235-stcrozdw 605 29 km km NNS cord-020235-stcrozdw 605 30 ) ) -RRB- cord-020235-stcrozdw 605 31 . . . cord-020235-stcrozdw 606 1 In in IN cord-020235-stcrozdw 606 2 both both DT cord-020235-stcrozdw 606 3 cases case NNS cord-020235-stcrozdw 606 4 Orthopoxvirus Orthopoxvirus NNP cord-020235-stcrozdw 606 5 strains strain NNS cord-020235-stcrozdw 606 6 could could MD cord-020235-stcrozdw 606 7 be be VB cord-020235-stcrozdw 606 8 isolated isolate VBN cord-020235-stcrozdw 606 9 which which WDT cord-020235-stcrozdw 606 10 were be VBD cord-020235-stcrozdw 606 11 similar similar JJ cord-020235-stcrozdw 606 12 but but CC cord-020235-stcrozdw 606 13 not not RB cord-020235-stcrozdw 606 14 identical identical JJ cord-020235-stcrozdw 606 15 in in IN cord-020235-stcrozdw 606 16 their -PRON- PRP$ cord-020235-stcrozdw 606 17 biological biological JJ cord-020235-stcrozdw 606 18 properties property NNS cord-020235-stcrozdw 606 19 ( ( -LRB- cord-020235-stcrozdw 606 20 small small JJ cord-020235-stcrozdw 606 21 efflorescences efflorescence NNS cord-020235-stcrozdw 606 22 on on IN cord-020235-stcrozdw 606 23 the the DT cord-020235-stcrozdw 606 24 CAM cam NN cord-020235-stcrozdw 606 25 with with IN cord-020235-stcrozdw 606 26 hemorrhagic hemorrhagic JJ cord-020235-stcrozdw 606 27 center center NN cord-020235-stcrozdw 606 28 , , , cord-020235-stcrozdw 606 29 inclusion inclusion NN cord-020235-stcrozdw 606 30 bodies body NNS cord-020235-stcrozdw 606 31 of of IN cord-020235-stcrozdw 606 32 type type NN cord-020235-stcrozdw 606 33 A a NN cord-020235-stcrozdw 606 34 V+ v+ ADD cord-020235-stcrozdw 606 35 , , , cord-020235-stcrozdw 606 36 high high JJ cord-020235-stcrozdw 606 37 pathogenicity pathogenicity NN cord-020235-stcrozdw 606 38 for for IN cord-020235-stcrozdw 606 39 rabbit rabbit NN cord-020235-stcrozdw 606 40 skin skin NN cord-020235-stcrozdw 606 41 , , , cord-020235-stcrozdw 606 42 characteristic characteristic JJ cord-020235-stcrozdw 606 43 skin skin NN cord-020235-stcrozdw 606 44 lesions lesion NNS cord-020235-stcrozdw 606 45 in in IN cord-020235-stcrozdw 606 46 adult adult NN cord-020235-stcrozdw 606 47 mice mouse NNS cord-020235-stcrozdw 606 48 ) ) -RRB- cord-020235-stcrozdw 606 49 and and CC cord-020235-stcrozdw 606 50 their -PRON- PRP$ cord-020235-stcrozdw 606 51 DNA dna NN cord-020235-stcrozdw 606 52 restriction restriction NN cord-020235-stcrozdw 606 53 patterns pattern NNS cord-020235-stcrozdw 606 54 ( ( -LRB- cord-020235-stcrozdw 606 55 Xho Xho NNP cord-020235-stcrozdw 606 56 I I NNP cord-020235-stcrozdw 606 57 , , , cord-020235-stcrozdw 606 58 Eco Eco NNP cord-020235-stcrozdw 606 59 R r NN cord-020235-stcrozdw 606 60 I i NN cord-020235-stcrozdw 606 61 , , , cord-020235-stcrozdw 606 62 Hin Hin NNP cord-020235-stcrozdw 606 63 d d NNP cord-020235-stcrozdw 606 64 III III NNP cord-020235-stcrozdw 606 65 ) ) -RRB- cord-020235-stcrozdw 606 66 . . . cord-020235-stcrozdw 607 1 Both both DT cord-020235-stcrozdw 607 2 virus virus NN cord-020235-stcrozdw 607 3 strains strain NNS cord-020235-stcrozdw 607 4 were be VBD cord-020235-stcrozdw 607 5 incorporated incorporate VBN cord-020235-stcrozdw 607 6 into into IN cord-020235-stcrozdw 607 7 the the DT cord-020235-stcrozdw 607 8 group group NN cord-020235-stcrozdw 607 9 of of IN cord-020235-stcrozdw 607 10 " " `` cord-020235-stcrozdw 607 11 cowpoxlike cowpoxlike JJ cord-020235-stcrozdw 607 12 viruses virus NNS cord-020235-stcrozdw 607 13 " " '' cord-020235-stcrozdw 607 14 ( ( -LRB- cord-020235-stcrozdw 607 15 Baxby Baxby NNP cord-020235-stcrozdw 607 16 and and CC cord-020235-stcrozdw 607 17 Ghaboosi Ghaboosi NNP cord-020235-stcrozdw 607 18 , , , cord-020235-stcrozdw 607 19 1977 1977 CD cord-020235-stcrozdw 607 20 ) ) -RRB- cord-020235-stcrozdw 607 21 . . . cord-020235-stcrozdw 608 1 The the DT cord-020235-stcrozdw 608 2 results result NNS cord-020235-stcrozdw 608 3 indicate indicate VBP cord-020235-stcrozdw 608 4 that that IN cord-020235-stcrozdw 608 5 both both DT cord-020235-stcrozdw 608 6 outbreaks outbreak NNS cord-020235-stcrozdw 608 7 had have VBD cord-020235-stcrozdw 608 8 occurred occur VBN cord-020235-stcrozdw 608 9 independently independently RB cord-020235-stcrozdw 608 10 from from IN cord-020235-stcrozdw 608 11 each each DT cord-020235-stcrozdw 608 12 other other JJ cord-020235-stcrozdw 608 13 . . . cord-020235-stcrozdw 609 1 Characterization characterization NN cord-020235-stcrozdw 609 2 of of IN cord-020235-stcrozdw 609 3 a a DT cord-020235-stcrozdw 609 4 37 37 CD cord-020235-stcrozdw 609 5 K K NNP cord-020235-stcrozdw 609 6 Protein Protein NNP cord-020235-stcrozdw 609 7 Specifically specifically RB cord-020235-stcrozdw 609 8 Associated associate VBN cord-020235-stcrozdw 609 9 with with IN cord-020235-stcrozdw 609 10 Released release VBN cord-020235-stcrozdw 609 11 Extracellular Extracellular NNP cord-020235-stcrozdw 609 12 Vaccinia Vaccinia NNP cord-020235-stcrozdw 609 13 Particles Particles NNP cord-020235-stcrozdw 609 14 HILLER HILLER NNP cord-020235-stcrozdw 609 15 G. G. NNP cord-020235-stcrozdw 609 16 and and CC cord-020235-stcrozdw 609 17 AULBACH AULBACH NNP cord-020235-stcrozdw 609 18 , , , cord-020235-stcrozdw 609 19 H. H. NNP cord-020235-stcrozdw 609 20 Infectious infectious JJ cord-020235-stcrozdw 609 21 vaccinia vaccinia NN cord-020235-stcrozdw 609 22 virus virus NN cord-020235-stcrozdw 609 23 can can MD cord-020235-stcrozdw 609 24 be be VB cord-020235-stcrozdw 609 25 isolated isolate VBN cord-020235-stcrozdw 609 26 from from IN cord-020235-stcrozdw 609 27 infected infected JJ cord-020235-stcrozdw 609 28 cells cell NNS cord-020235-stcrozdw 609 29 after after IN cord-020235-stcrozdw 609 30 experimentally experimentally RB cord-020235-stcrozdw 609 31 induced induce VBN cord-020235-stcrozdw 609 32 lysis lysis NN cord-020235-stcrozdw 609 33 ( ( -LRB- cord-020235-stcrozdw 609 34 intracellular intracellular JJ cord-020235-stcrozdw 609 35 virus virus NN cord-020235-stcrozdw 609 36 ) ) -RRB- cord-020235-stcrozdw 609 37 or or CC cord-020235-stcrozdw 609 38 from from IN cord-020235-stcrozdw 609 39 the the DT cord-020235-stcrozdw 609 40 growth growth NN cord-020235-stcrozdw 609 41 medium medium NN cord-020235-stcrozdw 609 42 of of IN cord-020235-stcrozdw 609 43 infected infected JJ cord-020235-stcrozdw 609 44 cultures culture NNS cord-020235-stcrozdw 609 45 ( ( -LRB- cord-020235-stcrozdw 609 46 extracellular extracellular JJ cord-020235-stcrozdw 609 47 virus virus NN cord-020235-stcrozdw 609 48 ) ) -RRB- cord-020235-stcrozdw 609 49 . . . cord-020235-stcrozdw 610 1 We -PRON- PRP cord-020235-stcrozdw 610 2 have have VBP cord-020235-stcrozdw 610 3 characterized characterize VBN cord-020235-stcrozdw 610 4 a a DT cord-020235-stcrozdw 610 5 37 37 CD cord-020235-stcrozdw 610 6 K K NNP cord-020235-stcrozdw 610 7 protein protein NN cord-020235-stcrozdw 610 8 only only RB cord-020235-stcrozdw 610 9 present present JJ cord-020235-stcrozdw 610 10 on on IN cord-020235-stcrozdw 610 11 extracellular extracellular JJ cord-020235-stcrozdw 610 12 particles particle NNS cord-020235-stcrozdw 610 13 by by IN cord-020235-stcrozdw 610 14 its -PRON- PRP$ cord-020235-stcrozdw 610 15 amino amino NN cord-020235-stcrozdw 610 16 acid acid NN cord-020235-stcrozdw 610 17 composition composition NN cord-020235-stcrozdw 610 18 and and CC cord-020235-stcrozdw 610 19 its -PRON- PRP$ cord-020235-stcrozdw 610 20 behaviour behaviour NN cord-020235-stcrozdw 610 21 on on IN cord-020235-stcrozdw 610 22 isoelectric isoelectric JJ cord-020235-stcrozdw 610 23 focusing focus VBG cord-020235-stcrozdw 610 24 . . . cord-020235-stcrozdw 611 1 In in IN cord-020235-stcrozdw 611 2 addition addition NN cord-020235-stcrozdw 611 3 we -PRON- PRP cord-020235-stcrozdw 611 4 have have VBP cord-020235-stcrozdw 611 5 used use VBN cord-020235-stcrozdw 611 6 a a DT cord-020235-stcrozdw 611 7 37K 37k JJ cord-020235-stcrozdw 611 8 - - HYPH cord-020235-stcrozdw 611 9 specific specific JJ cord-020235-stcrozdw 611 10 antiserum antiserum NN cord-020235-stcrozdw 611 11 to to TO cord-020235-stcrozdw 611 12 detect detect VB cord-020235-stcrozdw 611 13 its -PRON- PRP$ cord-020235-stcrozdw 611 14 distribution distribution NN cord-020235-stcrozdw 611 15 within within IN cord-020235-stcrozdw 611 16 infected infected JJ cord-020235-stcrozdw 611 17 cells cell NNS cord-020235-stcrozdw 611 18 . . . cord-020235-stcrozdw 612 1 -37 -37 NNP cord-020235-stcrozdw 613 1 K K NNP cord-020235-stcrozdw 613 2 protein protein NN cord-020235-stcrozdw 613 3 is be VBZ cord-020235-stcrozdw 613 4 a a DT cord-020235-stcrozdw 613 5 late late JJ cord-020235-stcrozdw 613 6 viral viral JJ cord-020235-stcrozdw 613 7 protein protein NN cord-020235-stcrozdw 613 8 appearing appear VBG cord-020235-stcrozdw 613 9 5 5 CD cord-020235-stcrozdw 613 10 - - SYM cord-020235-stcrozdw 613 11 6 6 CD cord-020235-stcrozdw 613 12 h h NN cord-020235-stcrozdw 613 13 p.i p.i NNP cord-020235-stcrozdw 613 14 . . . cord-020235-stcrozdw 614 1 It -PRON- PRP cord-020235-stcrozdw 614 2 is be VBZ cord-020235-stcrozdw 614 3 predominantly predominantly RB cord-020235-stcrozdw 614 4 found find VBN cord-020235-stcrozdw 614 5 associated associate VBN cord-020235-stcrozdw 614 6 with with IN cord-020235-stcrozdw 614 7 the the DT cord-020235-stcrozdw 614 8 cellular cellular JJ cord-020235-stcrozdw 614 9 Golgi Golgi NNP cord-020235-stcrozdw 614 10 complex complex NN cord-020235-stcrozdw 614 11 but but CC cord-020235-stcrozdw 614 12 never never RB cord-020235-stcrozdw 614 13 with with IN cord-020235-stcrozdw 614 14 structures structure NNS cord-020235-stcrozdw 614 15 representing represent VBG cord-020235-stcrozdw 614 16 pox pox NN cord-020235-stcrozdw 614 17 virus virus NN cord-020235-stcrozdw 614 18 " " '' cord-020235-stcrozdw 614 19 factories factory NNS cord-020235-stcrozdw 614 20 " " '' cord-020235-stcrozdw 614 21 . . . cord-020235-stcrozdw 615 1 Later later RB cord-020235-stcrozdw 615 2 in in IN cord-020235-stcrozdw 615 3 infection infection NN cord-020235-stcrozdw 615 4 37 37 CD cord-020235-stcrozdw 615 5 K K NNP cord-020235-stcrozdw 615 6 protein protein NN cord-020235-stcrozdw 615 7 is be VBZ cord-020235-stcrozdw 615 8 incorporated incorporate VBN cord-020235-stcrozdw 615 9 into into IN cord-020235-stcrozdw 615 10 single single JJ cord-020235-stcrozdw 615 11 viral viral JJ cord-020235-stcrozdw 615 12 particles particle NNS cord-020235-stcrozdw 615 13 preferentially preferentially RB cord-020235-stcrozdw 615 14 found find VBN cord-020235-stcrozdw 615 15 in in IN cord-020235-stcrozdw 615 16 the the DT cord-020235-stcrozdw 615 17 cell cell NN cord-020235-stcrozdw 615 18 periphery periphery NN cord-020235-stcrozdw 615 19 . . . cord-020235-stcrozdw 616 1 Upon upon IN cord-020235-stcrozdw 616 2 electron electron NN cord-020235-stcrozdw 616 3 microscopy microscopy NN cord-020235-stcrozdw 616 4 approximately approximately RB cord-020235-stcrozdw 616 5 3040 3040 CD cord-020235-stcrozdw 616 6 % % NN cord-020235-stcrozdw 616 7 of of IN cord-020235-stcrozdw 616 8 morphologically morphologically RB cord-020235-stcrozdw 616 9 mature mature JJ cord-020235-stcrozdw 616 10 virions virion NNS cord-020235-stcrozdw 616 11 inside inside IN cord-020235-stcrozdw 616 12 the the DT cord-020235-stcrozdw 616 13 cell cell NN cord-020235-stcrozdw 616 14 are be VBP cord-020235-stcrozdw 616 15 enwrapped enwrap VBN cord-020235-stcrozdw 616 16 by by IN cord-020235-stcrozdw 616 17 a a DT cord-020235-stcrozdw 616 18 double double JJ cord-020235-stcrozdw 616 19 - - HYPH cord-020235-stcrozdw 616 20 membranate membranate JJ cord-020235-stcrozdw 616 21 vesicular vesicular JJ cord-020235-stcrozdw 616 22 structure structure NN cord-020235-stcrozdw 616 23 . . . cord-020235-stcrozdw 617 1 Thus thus RB cord-020235-stcrozdw 617 2 37 37 CD cord-020235-stcrozdw 617 3 K k NN cord-020235-stcrozdw 617 4 viral viral JJ cord-020235-stcrozdw 617 5 protein protein NN cord-020235-stcrozdw 617 6 is be VBZ cord-020235-stcrozdw 617 7 probably probably RB cord-020235-stcrozdw 617 8 a a DT cord-020235-stcrozdw 617 9 component component NN cord-020235-stcrozdw 617 10 of of IN cord-020235-stcrozdw 617 11 this this DT cord-020235-stcrozdw 617 12 vesicular vesicular JJ cord-020235-stcrozdw 617 13 structure structure NN cord-020235-stcrozdw 617 14 and and CC cord-020235-stcrozdw 617 15 only only RB cord-020235-stcrozdw 617 16 vesiculated vesiculated JJ cord-020235-stcrozdw 617 17 virions virion NNS cord-020235-stcrozdw 617 18 can can MD cord-020235-stcrozdw 617 19 be be VB cord-020235-stcrozdw 617 20 released release VBN cord-020235-stcrozdw 617 21 by by IN cord-020235-stcrozdw 617 22 the the DT cord-020235-stcrozdw 617 23 cell cell NN cord-020235-stcrozdw 617 24 before before IN cord-020235-stcrozdw 617 25 lysis lysis NN cord-020235-stcrozdw 617 26 occurs occur VBZ cord-020235-stcrozdw 617 27 . . . cord-020235-stcrozdw 618 1 Epidemiology epidemiology NN cord-020235-stcrozdw 618 2 of of IN cord-020235-stcrozdw 618 3 Influenza Influenza NNP cord-020235-stcrozdw 618 4 in in IN cord-020235-stcrozdw 618 5 Lower Lower NNP cord-020235-stcrozdw 618 6 Saxony Saxony NNP cord-020235-stcrozdw 618 7 WILLERS WILLERS NNP cord-020235-stcrozdw 618 8 , , , cord-020235-stcrozdw 618 9 H. H. NNP cord-020235-stcrozdw 618 10 and and CC cord-020235-stcrozdw 618 11 HOPKEN HOPKEN NNP cord-020235-stcrozdw 618 12 , , , cord-020235-stcrozdw 618 13 W. W. NNP cord-020235-stcrozdw 619 1 The the DT cord-020235-stcrozdw 619 2 influenza influenza NN cord-020235-stcrozdw 619 3 surveillance surveillance NN cord-020235-stcrozdw 619 4 in in IN cord-020235-stcrozdw 619 5 Lower Lower NNP cord-020235-stcrozdw 619 6 Saxony Saxony NNP cord-020235-stcrozdw 619 7 is be VBZ cord-020235-stcrozdw 619 8 mainly mainly RB cord-020235-stcrozdw 619 9 based base VBN cord-020235-stcrozdw 619 10 on on IN cord-020235-stcrozdw 619 11 laboratory laboratory NN cord-020235-stcrozdw 619 12 investigations investigation NNS cord-020235-stcrozdw 619 13 especially especially RB cord-020235-stcrozdw 619 14 on on IN cord-020235-stcrozdw 619 15 the the DT cord-020235-stcrozdw 619 16 attempts attempt NNS cord-020235-stcrozdw 619 17 to to TO cord-020235-stcrozdw 619 18 isolate isolate VB cord-020235-stcrozdw 619 19 influenza influenza NN cord-020235-stcrozdw 619 20 viruses virus NNS cord-020235-stcrozdw 619 21 throughout throughout IN cord-020235-stcrozdw 619 22 the the DT cord-020235-stcrozdw 619 23 year year NN cord-020235-stcrozdw 619 24 . . . cord-020235-stcrozdw 620 1 -In -In : cord-020235-stcrozdw 620 2 the the DT cord-020235-stcrozdw 620 3 winter winter NN cord-020235-stcrozdw 620 4 1977 1977 CD cord-020235-stcrozdw 620 5 - - SYM cord-020235-stcrozdw 620 6 78 78 CD cord-020235-stcrozdw 620 7 and and CC cord-020235-stcrozdw 620 8 in in IN cord-020235-stcrozdw 620 9 the the DT cord-020235-stcrozdw 620 10 winter winter NN cord-020235-stcrozdw 620 11 1980 1980 CD cord-020235-stcrozdw 620 12 - - SYM cord-020235-stcrozdw 620 13 81 81 CD cord-020235-stcrozdw 620 14 the the DT cord-020235-stcrozdw 620 15 two two CD cord-020235-stcrozdw 620 16 influenza influenza NN cord-020235-stcrozdw 620 17 subtypes subtype NNS cord-020235-stcrozdw 620 18 H3N2 H3N2 NNP cord-020235-stcrozdw 620 19 and and CC cord-020235-stcrozdw 620 20 HINI HINI NNP cord-020235-stcrozdw 620 21 circulated circulate VBD cord-020235-stcrozdw 620 22 at at IN cord-020235-stcrozdw 620 23 the the DT cord-020235-stcrozdw 620 24 same same JJ cord-020235-stcrozdw 620 25 time time NN cord-020235-stcrozdw 620 26 . . . cord-020235-stcrozdw 621 1 The the DT cord-020235-stcrozdw 621 2 H3N2 H3N2 NNP cord-020235-stcrozdw 621 3 subtype subtype NN cord-020235-stcrozdw 621 4 affected affect VBN cord-020235-stcrozdw 621 5 during during IN cord-020235-stcrozdw 621 6 the the DT cord-020235-stcrozdw 621 7 last last JJ cord-020235-stcrozdw 621 8 years year NNS cord-020235-stcrozdw 621 9 persons person NNS cord-020235-stcrozdw 621 10 of of IN cord-020235-stcrozdw 621 11 all all DT cord-020235-stcrozdw 621 12 age age NN cord-020235-stcrozdw 621 13 - - HYPH cord-020235-stcrozdw 621 14 groups group NNS cord-020235-stcrozdw 621 15 whereas whereas IN cord-020235-stcrozdw 621 16 the the DT cord-020235-stcrozdw 621 17 HINI HINI NNP cord-020235-stcrozdw 621 18 subtype subtype NN cord-020235-stcrozdw 621 19 affected affect VBD cord-020235-stcrozdw 621 20 only only RB cord-020235-stcrozdw 621 21 persons person NNS cord-020235-stcrozdw 621 22 younger young JJR cord-020235-stcrozdw 621 23 than than IN cord-020235-stcrozdw 621 24 30 30 CD cord-020235-stcrozdw 621 25 years year NNS cord-020235-stcrozdw 621 26 . . . cord-020235-stcrozdw 622 1 -In -In . cord-020235-stcrozdw 623 1 the the DT cord-020235-stcrozdw 623 2 winter winter NN cord-020235-stcrozdw 623 3 1978 1978 CD cord-020235-stcrozdw 623 4 - - SYM cord-020235-stcrozdw 623 5 79 79 CD cord-020235-stcrozdw 623 6 influenza influenza NN cord-020235-stcrozdw 623 7 B b NN cord-020235-stcrozdw 623 8 was be VBD cord-020235-stcrozdw 623 9 found find VBN cord-020235-stcrozdw 623 10 in in IN cord-020235-stcrozdw 623 11 an an DT cord-020235-stcrozdw 623 12 epidemiological epidemiological JJ cord-020235-stcrozdw 623 13 extent extent NN cord-020235-stcrozdw 623 14 . . . cord-020235-stcrozdw 624 1 The the DT cord-020235-stcrozdw 624 2 disease disease NN cord-020235-stcrozdw 624 3 caused cause VBD cord-020235-stcrozdw 624 4 outbreaks outbreak NNS cord-020235-stcrozdw 624 5 mostly mostly RB cord-020235-stcrozdw 624 6 in in IN cord-020235-stcrozdw 624 7 schools school NNS cord-020235-stcrozdw 624 8 and and CC cord-020235-stcrozdw 624 9 kindergartens kindergarten NNS cord-020235-stcrozdw 624 10 but but CC cord-020235-stcrozdw 624 11 also also RB cord-020235-stcrozdw 624 12 affected affect VBD cord-020235-stcrozdw 624 13 adults adult NNS cord-020235-stcrozdw 624 14 . . . cord-020235-stcrozdw 625 1 -In -In : cord-020235-stcrozdw 625 2 1980 1980 CD cord-020235-stcrozdw 625 3 - - SYM cord-020235-stcrozdw 625 4 81 81 CD cord-020235-stcrozdw 625 5 from from IN cord-020235-stcrozdw 625 6 mid mid NNP cord-020235-stcrozdw 625 7 - - NNP cord-020235-stcrozdw 625 8 January January NNP cord-020235-stcrozdw 625 9 to to IN cord-020235-stcrozdw 625 10 mid mid NNP cord-020235-stcrozdw 625 11 - - NNP cord-020235-stcrozdw 625 12 February February NNP cord-020235-stcrozdw 625 13 scattered scatter VBN cord-020235-stcrozdw 625 14 outbreaks outbreak NNS cord-020235-stcrozdw 625 15 were be VBD cord-020235-stcrozdw 625 16 caused cause VBN cord-020235-stcrozdw 625 17 by by IN cord-020235-stcrozdw 625 18 the the DT cord-020235-stcrozdw 625 19 A A NNP cord-020235-stcrozdw 625 20 subtype subtype NN cord-020235-stcrozdw 625 21 HINl hinl NN cord-020235-stcrozdw 625 22 , , , cord-020235-stcrozdw 625 23 which which WDT cord-020235-stcrozdw 625 24 particularly particularly RB cord-020235-stcrozdw 625 25 affected affect VBD cord-020235-stcrozdw 625 26 schoolchildren schoolchildren NNS cord-020235-stcrozdw 625 27 contrarily contrarily RB cord-020235-stcrozdw 625 28 to to IN cord-020235-stcrozdw 625 29 1978 1978 CD cord-020235-stcrozdw 625 30 where where WRB cord-020235-stcrozdw 625 31 the the DT cord-020235-stcrozdw 625 32 HINI HINI NNP cord-020235-stcrozdw 625 33 subtype subtype NN cord-020235-stcrozdw 625 34 mostly mostly RB cord-020235-stcrozdw 625 35 infected infect VBN cord-020235-stcrozdw 625 36 young young JJ cord-020235-stcrozdw 625 37 adults adult NNS cord-020235-stcrozdw 625 38 . . . cord-020235-stcrozdw 626 1 Influenza influenza NN cord-020235-stcrozdw 626 2 of of IN cord-020235-stcrozdw 626 3 the the DT cord-020235-stcrozdw 626 4 H3N2 H3N2 NNP cord-020235-stcrozdw 626 5 subtype subtype NN cord-020235-stcrozdw 626 6 circulated circulate VBN cord-020235-stcrozdw 626 7 from from IN cord-020235-stcrozdw 626 8 January January NNP cord-020235-stcrozdw 626 9 to to IN cord-020235-stcrozdw 626 10 March March NNP cord-020235-stcrozdw 626 11 . . . cord-020235-stcrozdw 627 1 Inst Inst NNP cord-020235-stcrozdw 627 2 . . . cord-020235-stcrozdw 628 1 f. f. NNP cord-020235-stcrozdw 628 2 med med NNP cord-020235-stcrozdw 628 3 . . . cord-020235-stcrozdw 629 1 Mikrobiologie Mikrobiologie NNP cord-020235-stcrozdw 629 2 . . . cord-020235-stcrozdw 630 1 Abr Abr NNP cord-020235-stcrozdw 630 2 , , , cord-020235-stcrozdw 630 3 Virologie Virologie NNP cord-020235-stcrozdw 630 4 d. d. NNP cord-020235-stcrozdw 630 5 TU TU NNP cord-020235-stcrozdw 630 6 , , , cord-020235-stcrozdw 630 7 Biedersteiner Biedersteiner NNP cord-020235-stcrozdw 630 8 Str Str NNP cord-020235-stcrozdw 630 9 . . NNP cord-020235-stcrozdw 630 10 29 29 CD cord-020235-stcrozdw 630 11 , , , cord-020235-stcrozdw 630 12 Antibodies Antibodies NNPS cord-020235-stcrozdw 630 13 against against IN cord-020235-stcrozdw 630 14 Influenza Influenza NNP cord-020235-stcrozdw 630 15 C C NNP cord-020235-stcrozdw 630 16 Virus Virus NNP cord-020235-stcrozdw 630 17 in in IN cord-020235-stcrozdw 630 18 the the DT cord-020235-stcrozdw 630 19 Population Population NNP cord-020235-stcrozdw 630 20 of of IN cord-020235-stcrozdw 630 21 Germany Germany NNP cord-020235-stcrozdw 630 22 , , , cord-020235-stcrozdw 630 23 Kenia Kenia NNP cord-020235-stcrozdw 630 24 and and CC cord-020235-stcrozdw 630 25 Australia Australia NNP cord-020235-stcrozdw 630 26 PFEIL PFEIL NNP cord-020235-stcrozdw 630 27 - - HYPH cord-020235-stcrozdw 630 28 PUTZIEN PUTZIEN NNP cord-020235-stcrozdw 630 29 , , , cord-020235-stcrozdw 630 30 C. C. NNP cord-020235-stcrozdw 630 31 and and CC cord-020235-stcrozdw 630 32 MEIER MEIER NNP cord-020235-stcrozdw 630 33 - - HYPH cord-020235-stcrozdw 630 34 EWERT EWERT NNP cord-020235-stcrozdw 630 35 , , , cord-020235-stcrozdw 630 36 H. h. NN cord-020235-stcrozdw 631 1 Over over IN cord-020235-stcrozdw 631 2 one one CD cord-020235-stcrozdw 631 3 hundred hundred CD cord-020235-stcrozdw 631 4 human human NN cord-020235-stcrozdw 631 5 sera sera NNP cord-020235-stcrozdw 631 6 from from IN cord-020235-stcrozdw 631 7 each each DT cord-020235-stcrozdw 631 8 of of IN cord-020235-stcrozdw 631 9 the the DT cord-020235-stcrozdw 631 10 three three CD cord-020235-stcrozdw 631 11 countries country NNS cord-020235-stcrozdw 631 12 Germany Germany NNP cord-020235-stcrozdw 632 1 , , , cord-020235-stcrozdw 632 2 Kenia Kenia NNP cord-020235-stcrozdw 632 3 and and CC cord-020235-stcrozdw 632 4 Australia Australia NNP cord-020235-stcrozdw 632 5 were be VBD cord-020235-stcrozdw 632 6 tested test VBN cord-020235-stcrozdw 632 7 for for IN cord-020235-stcrozdw 632 8 antibodies antibody NNS cord-020235-stcrozdw 632 9 against against IN cord-020235-stcrozdw 632 10 influenza influenza NN cord-020235-stcrozdw 632 11 C C NNP cord-020235-stcrozdw 632 12 virus virus NN cord-020235-stcrozdw 632 13 , , , cord-020235-stcrozdw 632 14 using use VBG cord-020235-stcrozdw 632 15 the the DT cord-020235-stcrozdw 632 16 conventional conventional JJ cord-020235-stcrozdw 632 17 hemagglutination hemagglutination NN cord-020235-stcrozdw 632 18 inhibition inhibition NN cord-020235-stcrozdw 632 19 test test NN cord-020235-stcrozdw 632 20 ( ( -LRB- cord-020235-stcrozdw 632 21 HI HI NNP cord-020235-stcrozdw 632 22 ) ) -RRB- cord-020235-stcrozdw 632 23 . . . cord-020235-stcrozdw 633 1 The the DT cord-020235-stcrozdw 633 2 rate rate NN cord-020235-stcrozdw 633 3 of of IN cord-020235-stcrozdw 633 4 positive positive JJ cord-020235-stcrozdw 633 5 sera sera NNP cord-020235-stcrozdw 633 6 , , , cord-020235-stcrozdw 633 7 showing show VBG cord-020235-stcrozdw 633 8 a a DT cord-020235-stcrozdw 633 9 HI HI NNP cord-020235-stcrozdw 633 10 titer titer NN cord-020235-stcrozdw 633 11 8 8 CD cord-020235-stcrozdw 633 12 amounted amount VBD cord-020235-stcrozdw 633 13 to to IN cord-020235-stcrozdw 633 14 59 59 CD cord-020235-stcrozdw 633 15 Ofo Ofo NNP cord-020235-stcrozdw 633 16 for for IN cord-020235-stcrozdw 633 17 Germany Germany NNP cord-020235-stcrozdw 633 18 , , , cord-020235-stcrozdw 633 19 93 93 CD cord-020235-stcrozdw 633 20 Ofo Ofo NNP cord-020235-stcrozdw 633 21 for for IN cord-020235-stcrozdw 633 22 Kenia Kenia NNP cord-020235-stcrozdw 633 23 and and CC cord-020235-stcrozdw 633 24 96 96 CD cord-020235-stcrozdw 633 25 Ofo Ofo NNP cord-020235-stcrozdw 633 26 for for IN cord-020235-stcrozdw 633 27 Australia Australia NNP cord-020235-stcrozdw 633 28 . . . cord-020235-stcrozdw 634 1 In in IN cord-020235-stcrozdw 634 2 the the DT cord-020235-stcrozdw 634 3 age age NN cord-020235-stcrozdw 634 4 group group NN cord-020235-stcrozdw 634 5 up up IN cord-020235-stcrozdw 634 6 to to TO cord-020235-stcrozdw 634 7 5 5 CD cord-020235-stcrozdw 634 8 years year NNS cord-020235-stcrozdw 634 9 , , , cord-020235-stcrozdw 634 10 34 34 CD cord-020235-stcrozdw 634 11 Ofo Ofo NNP cord-020235-stcrozdw 634 12 of of IN cord-020235-stcrozdw 634 13 German german JJ cord-020235-stcrozdw 634 14 and and CC cord-020235-stcrozdw 634 15 94 94 CD cord-020235-stcrozdw 634 16 Ofo Ofo NNP cord-020235-stcrozdw 634 17 of of IN cord-020235-stcrozdw 634 18 kenian kenian NNP cord-020235-stcrozdw 634 19 sera sera NNP cord-020235-stcrozdw 634 20 had have VBD cord-020235-stcrozdw 634 21 already already RB cord-020235-stcrozdw 634 22 antibody antibody NN cord-020235-stcrozdw 634 23 titers titer NNS cord-020235-stcrozdw 634 24 against against IN cord-020235-stcrozdw 634 25 influenza influenza NN cord-020235-stcrozdw 634 26 C C NNP cord-020235-stcrozdw 634 27 virus virus NN cord-020235-stcrozdw 634 28 . . . cord-020235-stcrozdw 635 1 The the DT cord-020235-stcrozdw 635 2 australian australian JJ cord-020235-stcrozdw 635 3 sera sera NNP cord-020235-stcrozdw 635 4 were be VBD cord-020235-stcrozdw 635 5 tested test VBN cord-020235-stcrozdw 635 6 for for IN cord-020235-stcrozdw 635 7 the the DT cord-020235-stcrozdw 635 8 age age NN cord-020235-stcrozdw 635 9 group group NN cord-020235-stcrozdw 635 10 of of IN cord-020235-stcrozdw 635 11 16 16 CD cord-020235-stcrozdw 635 12 - - SYM cord-020235-stcrozdw 635 13 25 25 CD cord-020235-stcrozdw 635 14 years year NNS cord-020235-stcrozdw 635 15 and and CC cord-020235-stcrozdw 635 16 showed show VBD cord-020235-stcrozdw 635 17 95 95 CD cord-020235-stcrozdw 635 18 Ofo Ofo NNP cord-020235-stcrozdw 635 19 seropositivity seropositivity NN cord-020235-stcrozdw 635 20 . . . cord-020235-stcrozdw 636 1 The the DT cord-020235-stcrozdw 636 2 results result NNS cord-020235-stcrozdw 636 3 show show VBP cord-020235-stcrozdw 636 4 that that IN cord-020235-stcrozdw 636 5 influenza influenza NN cord-020235-stcrozdw 636 6 C c NN cord-020235-stcrozdw 636 7 virus virus NN cord-020235-stcrozdw 636 8 is be VBZ cord-020235-stcrozdw 636 9 circulating circulate VBG cord-020235-stcrozdw 636 10 to to IN cord-020235-stcrozdw 636 11 a a DT cord-020235-stcrozdw 636 12 higher high JJR cord-020235-stcrozdw 636 13 extend extend NN cord-020235-stcrozdw 636 14 in in IN cord-020235-stcrozdw 636 15 the the DT cord-020235-stcrozdw 636 16 populations population NNS cord-020235-stcrozdw 636 17 of of IN cord-020235-stcrozdw 636 18 countries country NNS cord-020235-stcrozdw 636 19 with with IN cord-020235-stcrozdw 636 20 subtropical subtropical JJ cord-020235-stcrozdw 636 21 climate climate NN cord-020235-stcrozdw 636 22 , , , cord-020235-stcrozdw 636 23 as as IN cord-020235-stcrozdw 636 24 compared compare VBN cord-020235-stcrozdw 636 25 to to IN cord-020235-stcrozdw 636 26 the the DT cord-020235-stcrozdw 636 27 more more RBR cord-020235-stcrozdw 636 28 temperate temperate JJ cord-020235-stcrozdw 636 29 middle middle JJ cord-020235-stcrozdw 636 30 european european JJ cord-020235-stcrozdw 636 31 zones zone NNS cord-020235-stcrozdw 636 32 . . . cord-020235-stcrozdw 637 1 Inst Inst NNP cord-020235-stcrozdw 637 2 , , , cord-020235-stcrozdw 637 3 f. f. NN cord-020235-stcrozdw 637 4 Virologie Virologie NNP cord-020235-stcrozdw 637 5 , , , cord-020235-stcrozdw 637 6 justus justus NNP cord-020235-stcrozdw 637 7 - - HYPH cord-020235-stcrozdw 637 8 Liebig Liebig NNP cord-020235-stcrozdw 637 9 - - HYPH cord-020235-stcrozdw 637 10 Univ Univ NNP cord-020235-stcrozdw 637 11 . . . cord-020235-stcrozdw 638 1 , , , cord-020235-stcrozdw 638 2 D-6300 d-6300 CD cord-020235-stcrozdw 639 1 Giessen Giessen NNP cord-020235-stcrozdw 640 1 The the DT cord-020235-stcrozdw 640 2 Proteolytic Proteolytic NNP cord-020235-stcrozdw 640 3 Activation Activation NNP cord-020235-stcrozdw 640 4 of of IN cord-020235-stcrozdw 640 5 Influenza Influenza NNP cord-020235-stcrozdw 640 6 Hemagglutinin Hemagglutinin NNP cord-020235-stcrozdw 640 7 , , , cord-020235-stcrozdw 640 8 Structure Structure NNP cord-020235-stcrozdw 640 9 of of IN cord-020235-stcrozdw 640 10 the the DT cord-020235-stcrozdw 640 11 Cleavage Cleavage NNP cord-020235-stcrozdw 640 12 Site Site NNP cord-020235-stcrozdw 640 13 and and CC cord-020235-stcrozdw 640 14 the the DT cord-020235-stcrozdw 640 15 Mechanism Mechanism NNP cord-020235-stcrozdw 640 16 of of IN cord-020235-stcrozdw 640 17 Cleavage Cleavage NNP cord-020235-stcrozdw 640 18 GARTEN GARTEN NNP cord-020235-stcrozdw 640 19 , , , cord-020235-stcrozdw 640 20 W. W. NNP cord-020235-stcrozdw 640 21 and and CC cord-020235-stcrozdw 640 22 BOSCH BOSCH NNP cord-020235-stcrozdw 640 23 , , , cord-020235-stcrozdw 640 24 F. F. NNP cord-020235-stcrozdw 640 25 X. X. NNP cord-020235-stcrozdw 641 1 The the DT cord-020235-stcrozdw 641 2 hemagglutinin hemagglutinin NN cord-020235-stcrozdw 641 3 precursor precursor NN cord-020235-stcrozdw 641 4 HA HA NNP cord-020235-stcrozdw 641 5 is be VBZ cord-020235-stcrozdw 641 6 posttranslationally posttranslationally RB cord-020235-stcrozdw 641 7 cleaved cleave VBN cord-020235-stcrozdw 641 8 by by IN cord-020235-stcrozdw 641 9 proteases protease NNS cord-020235-stcrozdw 641 10 to to IN cord-020235-stcrozdw 641 11 the the DT cord-020235-stcrozdw 641 12 complex complex JJ cord-020235-stcrozdw 641 13 H h NN cord-020235-stcrozdw 641 14 I i NN cord-020235-stcrozdw 641 15 , , , cord-020235-stcrozdw 641 16 2 2 CD cord-020235-stcrozdw 641 17 ' ' '' cord-020235-stcrozdw 642 1 In in IN cord-020235-stcrozdw 642 2 vitro vitro FW cord-020235-stcrozdw 642 3 cleavage cleavage NN cord-020235-stcrozdw 642 4 of of IN cord-020235-stcrozdw 642 5 HA HA NNP cord-020235-stcrozdw 642 6 by by IN cord-020235-stcrozdw 642 7 trypsin trypsin NN cord-020235-stcrozdw 642 8 and and CC cord-020235-stcrozdw 642 9 trysin trysin NNS cord-020235-stcrozdw 642 10 - - HYPH cord-020235-stcrozdw 642 11 like like JJ cord-020235-stcrozdw 642 12 proteases protease NNS cord-020235-stcrozdw 642 13 yields yield NNS cord-020235-stcrozdw 642 14 infectious infectious JJ cord-020235-stcrozdw 642 15 virus virus NN cord-020235-stcrozdw 642 16 . . . cord-020235-stcrozdw 643 1 Cleavage cleavage NN cord-020235-stcrozdw 643 2 by by IN cord-020235-stcrozdw 643 3 thermo thermo NNP cord-020235-stcrozdw 643 4 lysin lysin NNP cord-020235-stcrozdw 643 5 or or CC cord-020235-stcrozdw 643 6 chymotrypsin chymotrypsin NNP cord-020235-stcrozdw 643 7 yields yield VBZ cord-020235-stcrozdw 643 8 non non JJ cord-020235-stcrozdw 643 9 - - JJ cord-020235-stcrozdw 643 10 infectious infectious JJ cord-020235-stcrozdw 643 11 virus virus NN cord-020235-stcrozdw 643 12 . . . cord-020235-stcrozdw 644 1 We -PRON- PRP cord-020235-stcrozdw 644 2 have have VBP cord-020235-stcrozdw 644 3 analyzed analyze VBN cord-020235-stcrozdw 644 4 the the DT cord-020235-stcrozdw 644 5 cleavage cleavage NN cord-020235-stcrozdw 644 6 sites site NNS cord-020235-stcrozdw 644 7 of of IN cord-020235-stcrozdw 644 8 HI HI NNP cord-020235-stcrozdw 644 9 , , , cord-020235-stcrozdw 644 10 H3 H3 NNP cord-020235-stcrozdw 644 11 and and CC cord-020235-stcrozdw 644 12 HlO hlo NN cord-020235-stcrozdw 644 13 hemagglutinins hemagglutinins NNP cord-020235-stcrozdw 644 14 . . . cord-020235-stcrozdw 645 1 The the DT cord-020235-stcrozdw 645 2 amino amino NN cord-020235-stcrozdw 645 3 acid acid NN cord-020235-stcrozdw 645 4 sequences sequence NNS cord-020235-stcrozdw 645 5 at at IN cord-020235-stcrozdw 645 6 the the DT cord-020235-stcrozdw 645 7 cleavage cleavage NN cord-020235-stcrozdw 645 8 site site NN cord-020235-stcrozdw 645 9 , , , cord-020235-stcrozdw 645 10 i. i. NNP cord-020235-stcrozdw 645 11 e. e. NNP cord-020235-stcrozdw 645 12 C C NNP cord-020235-stcrozdw 645 13 - - HYPH cord-020235-stcrozdw 645 14 terminus terminus NN cord-020235-stcrozdw 645 15 of of IN cord-020235-stcrozdw 645 16 HAl hal JJ cord-020235-stcrozdw 645 17 and and CC cord-020235-stcrozdw 645 18 the the DT cord-020235-stcrozdw 645 19 N n NN cord-020235-stcrozdw 645 20 - - HYPH cord-020235-stcrozdw 645 21 terminus terminus NN cord-020235-stcrozdw 645 22 of of IN cord-020235-stcrozdw 645 23 HA HA NNP cord-020235-stcrozdw 645 24 2 2 CD cord-020235-stcrozdw 645 25 are be VBP cord-020235-stcrozdw 645 26 identical identical JJ cord-020235-stcrozdw 645 27 when when WRB cord-020235-stcrozdw 645 28 virus virus NN cord-020235-stcrozdw 645 29 is be VBZ cord-020235-stcrozdw 645 30 activated activate VBN cord-020235-stcrozdw 645 31 in in IN cord-020235-stcrozdw 645 32 vivo vivo NN cord-020235-stcrozdw 645 33 and and CC cord-020235-stcrozdw 645 34 in in IN cord-020235-stcrozdw 645 35 vitro vitro FW cord-020235-stcrozdw 645 36 . . . cord-020235-stcrozdw 646 1 Under under IN cord-020235-stcrozdw 646 2 both both DT cord-020235-stcrozdw 646 3 conditions condition NNS cord-020235-stcrozdw 646 4 , , , cord-020235-stcrozdw 646 5 an an DT cord-020235-stcrozdw 646 6 arginine arginine NN cord-020235-stcrozdw 646 7 residue residue NN cord-020235-stcrozdw 646 8 connecting connect VBG cord-020235-stcrozdw 646 9 HAl HAl NNP cord-020235-stcrozdw 646 10 and and CC cord-020235-stcrozdw 646 11 HA HA NNP cord-020235-stcrozdw 646 12 2 2 CD cord-020235-stcrozdw 646 13 in in IN cord-020235-stcrozdw 646 14 the the DT cord-020235-stcrozdw 646 15 precursor precursor NN cord-020235-stcrozdw 646 16 is be VBZ cord-020235-stcrozdw 646 17 eliminated eliminate VBN cord-020235-stcrozdw 646 18 . . . cord-020235-stcrozdw 647 1 The the DT cord-020235-stcrozdw 647 2 elimination elimination NN cord-020235-stcrozdw 647 3 of of IN cord-020235-stcrozdw 647 4 argmme argmme JJ cord-020235-stcrozdw 647 5 results result NNS cord-020235-stcrozdw 647 6 in in IN cord-020235-stcrozdw 647 7 a a DT cord-020235-stcrozdw 647 8 shift shift NN cord-020235-stcrozdw 647 9 of of IN cord-020235-stcrozdw 647 10 the the DT cord-020235-stcrozdw 647 11 isoelectric isoelectric JJ cord-020235-stcrozdw 647 12 point point NN cord-020235-stcrozdw 647 13 of of IN cord-020235-stcrozdw 647 14 the the DT cord-020235-stcrozdw 647 15 hemagglutinin hemagglutinin NN cord-020235-stcrozdw 647 16 as as IN cord-020235-stcrozdw 647 17 demonstrated demonstrate VBN cord-020235-stcrozdw 647 18 by by IN cord-020235-stcrozdw 647 19 isoelectric isoelectric JJ cord-020235-stcrozdw 647 20 focusing focus VBG cord-020235-stcrozdw 647 21 . . . cord-020235-stcrozdw 648 1 Non non JJ cord-020235-stcrozdw 648 2 - - JJ cord-020235-stcrozdw 648 3 activating activate VBG cord-020235-stcrozdw 648 4 enzymes enzyme NNS cord-020235-stcrozdw 648 5 cleave cleave VBP cord-020235-stcrozdw 648 6 only only RB cord-020235-stcrozdw 648 7 one one CD cord-020235-stcrozdw 648 8 peptide peptide NN cord-020235-stcrozdw 648 9 bond bond NN cord-020235-stcrozdw 648 10 in in IN cord-020235-stcrozdw 648 11 the the DT cord-020235-stcrozdw 648 12 HA HA NNP cord-020235-stcrozdw 648 13 2-Nterminal 2-nterminal CD cord-020235-stcrozdw 648 14 region region NN cord-020235-stcrozdw 648 15 of of IN cord-020235-stcrozdw 648 16 activated activate VBN cord-020235-stcrozdw 648 17 HA HA NNP cord-020235-stcrozdw 648 18 and and CC cord-020235-stcrozdw 648 19 thus thus RB cord-020235-stcrozdw 648 20 do do VBP cord-020235-stcrozdw 648 21 not not RB cord-020235-stcrozdw 648 22 affect affect VB cord-020235-stcrozdw 648 23 the the DT cord-020235-stcrozdw 648 24 isoelectric isoelectric JJ cord-020235-stcrozdw 648 25 point point NN cord-020235-stcrozdw 648 26 . . . cord-020235-stcrozdw 649 1 We -PRON- PRP cord-020235-stcrozdw 649 2 have have VBP cord-020235-stcrozdw 649 3 also also RB cord-020235-stcrozdw 649 4 analyzed analyze VBN cord-020235-stcrozdw 649 5 the the DT cord-020235-stcrozdw 649 6 cleavage cleavage NN cord-020235-stcrozdw 649 7 site site NN cord-020235-stcrozdw 649 8 of of IN cord-020235-stcrozdw 649 9 the the DT cord-020235-stcrozdw 649 10 hemagglutinin hemagglutinin NN cord-020235-stcrozdw 649 11 of of IN cord-020235-stcrozdw 649 12 fowl fowl NN cord-020235-stcrozdw 649 13 plaque plaque NN cord-020235-stcrozdw 649 14 virus virus NN cord-020235-stcrozdw 649 15 ( ( -LRB- cord-020235-stcrozdw 649 16 H7 H7 NNP cord-020235-stcrozdw 649 17 ) ) -RRB- cord-020235-stcrozdw 649 18 . . . cord-020235-stcrozdw 650 1 A a DT cord-020235-stcrozdw 650 2 connecting connect VBG cord-020235-stcrozdw 650 3 peptide peptide NN cord-020235-stcrozdw 650 4 containing contain VBG cord-020235-stcrozdw 650 5 several several JJ cord-020235-stcrozdw 650 6 basic basic JJ cord-020235-stcrozdw 650 7 amino amino NN cord-020235-stcrozdw 650 8 acids acid NNS cord-020235-stcrozdw 650 9 is be VBZ cord-020235-stcrozdw 650 10 eliminated eliminate VBN cord-020235-stcrozdw 650 11 . . . cord-020235-stcrozdw 651 1 -The -The NNP cord-020235-stcrozdw 651 2 data datum NNS cord-020235-stcrozdw 651 3 show show VBP cord-020235-stcrozdw 651 4 that that IN cord-020235-stcrozdw 651 5 activation activation NN cord-020235-stcrozdw 651 6 of of IN cord-020235-stcrozdw 651 7 the the DT cord-020235-stcrozdw 651 8 influenza influenza NN cord-020235-stcrozdw 651 9 hemagglutinin hemagglutinin NNP cord-020235-stcrozdw 651 10 involves involve VBZ cord-020235-stcrozdw 651 11 the the DT cord-020235-stcrozdw 651 12 action action NN cord-020235-stcrozdw 651 13 of of IN cord-020235-stcrozdw 651 14 a a DT cord-020235-stcrozdw 651 15 cellular cellular JJ cord-020235-stcrozdw 651 16 protease protease NN cord-020235-stcrozdw 651 17 with with IN cord-020235-stcrozdw 651 18 trypsin trypsin NN cord-020235-stcrozdw 651 19 - - HYPH cord-020235-stcrozdw 651 20 like like JJ cord-020235-stcrozdw 651 21 specificity specificity NN cord-020235-stcrozdw 651 22 followed follow VBN cord-020235-stcrozdw 651 23 by by IN cord-020235-stcrozdw 651 24 the the DT cord-020235-stcrozdw 651 25 action action NN cord-020235-stcrozdw 651 26 of of IN cord-020235-stcrozdw 651 27 an an DT cord-020235-stcrozdw 651 28 exopeptidase exopeptidase NN cord-020235-stcrozdw 651 29 of of IN cord-020235-stcrozdw 651 30 the the DT cord-020235-stcrozdw 651 31 carboxy carboxy JJ cord-020235-stcrozdw 651 32 - - HYPH cord-020235-stcrozdw 651 33 peptidase peptidase NN cord-020235-stcrozdw 651 34 B b NN cord-020235-stcrozdw 651 35 - - HYPH cord-020235-stcrozdw 651 36 type type NN cord-020235-stcrozdw 651 37 . . . cord-020235-stcrozdw 652 1 The the DT cord-020235-stcrozdw 652 2 latter latter JJ cord-020235-stcrozdw 652 3 enzyme enzyme NN cord-020235-stcrozdw 652 4 activity activity NN cord-020235-stcrozdw 652 5 is be VBZ cord-020235-stcrozdw 652 6 associated associate VBN cord-020235-stcrozdw 652 7 with with IN cord-020235-stcrozdw 652 8 purified purify VBN cord-020235-stcrozdw 652 9 virus virus NN cord-020235-stcrozdw 652 10 and and CC cord-020235-stcrozdw 652 11 can can MD cord-020235-stcrozdw 652 12 be be VB cord-020235-stcrozdw 652 13 analyzed analyze VBN cord-020235-stcrozdw 652 14 by by IN cord-020235-stcrozdw 652 15 an an DT cord-020235-stcrozdw 652 16 assay assay NN cord-020235-stcrozdw 652 17 employing employ VBG cord-020235-stcrozdw 652 18 peptides peptide NNS cord-020235-stcrozdw 652 19 bearing bear VBG cord-020235-stcrozdw 652 20 3H 3h NN cord-020235-stcrozdw 652 21 - - HYPH cord-020235-stcrozdw 652 22 arginine arginine NN cord-020235-stcrozdw 652 23 at at IN cord-020235-stcrozdw 652 24 the the DT cord-020235-stcrozdw 652 25 C C NNP cord-020235-stcrozdw 652 26 - - HYPH cord-020235-stcrozdw 652 27 terminus terminus NN cord-020235-stcrozdw 652 28 . . . cord-020235-stcrozdw 653 1 The the DT cord-020235-stcrozdw 653 2 carbohydrates carbohydrate NNS cord-020235-stcrozdw 653 3 of of IN cord-020235-stcrozdw 653 4 the the DT cord-020235-stcrozdw 653 5 glycoproteins glycoprotein NNS cord-020235-stcrozdw 653 6 of of IN cord-020235-stcrozdw 653 7 21 21 CD cord-020235-stcrozdw 653 8 influenza influenza NN cord-020235-stcrozdw 653 9 A a DT cord-020235-stcrozdw 653 10 strains strain NNS cord-020235-stcrozdw 653 11 containing contain VBG cord-020235-stcrozdw 653 12 hemagglutinin hemagglutinin NN cord-020235-stcrozdw 653 13 and and CC cord-020235-stcrozdw 653 14 neuraminidase neuraminidase NN cord-020235-stcrozdw 653 15 of of IN cord-020235-stcrozdw 653 16 all all DT cord-020235-stcrozdw 653 17 serotypes serotype NNS cord-020235-stcrozdw 653 18 known know VBN cord-020235-stcrozdw 653 19 to to IN cord-020235-stcrozdw 653 20 date date NN cord-020235-stcrozdw 653 21 have have VBP cord-020235-stcrozdw 653 22 been be VBN cord-020235-stcrozdw 653 23 compared compare VBN cord-020235-stcrozdw 653 24 by by IN cord-020235-stcrozdw 653 25 analysis analysis NN cord-020235-stcrozdw 653 26 of of IN cord-020235-stcrozdw 653 27 glycopeptides glycopeptides NNP cord-020235-stcrozdw 653 28 labeled label VBN cord-020235-stcrozdw 653 29 with with IN cord-020235-stcrozdw 653 30 radioactive radioactive JJ cord-020235-stcrozdw 653 31 sugars sugar NNS cord-020235-stcrozdw 653 32 . . . cord-020235-stcrozdw 654 1 Analysis analysis NN cord-020235-stcrozdw 654 2 of of IN cord-020235-stcrozdw 654 3 incompletely incompletely RB cord-020235-stcrozdw 654 4 glycosylated glycosylate VBN cord-020235-stcrozdw 654 5 glycoproteins glycoprotein NNS cord-020235-stcrozdw 654 6 synthesized synthesize VBN cord-020235-stcrozdw 654 7 in in IN cord-020235-stcrozdw 654 8 the the DT cord-020235-stcrozdw 654 9 presence presence NN cord-020235-stcrozdw 654 10 of of IN cord-020235-stcrozdw 654 11 glycosylation glycosylation NN cord-020235-stcrozdw 654 12 inhibitors inhibitor NNS cord-020235-stcrozdw 654 13 allowed allow VBD cord-020235-stcrozdw 654 14 the the DT cord-020235-stcrozdw 654 15 determination determination NN cord-020235-stcrozdw 654 16 of of IN cord-020235-stcrozdw 654 17 the the DT cord-020235-stcrozdw 654 18 number number NN cord-020235-stcrozdw 654 19 of of IN cord-020235-stcrozdw 654 20 oligosaccharide oligosaccharide NN cord-020235-stcrozdw 654 21 side side NN cord-020235-stcrozdw 654 22 chains chain NNS cord-020235-stcrozdw 654 23 on on IN cord-020235-stcrozdw 654 24 HA HA NNP cord-020235-stcrozdw 654 25 2 2 CD cord-020235-stcrozdw 654 26 • • NN cord-020235-stcrozdw 655 1 With with IN cord-020235-stcrozdw 655 2 all all DT cord-020235-stcrozdw 655 3 strains strain NNS cord-020235-stcrozdw 655 4 , , , cord-020235-stcrozdw 655 5 the the DT cord-020235-stcrozdw 655 6 neuraminidase neuraminidase NN cord-020235-stcrozdw 655 7 contains contain VBZ cord-020235-stcrozdw 655 8 side side NN cord-020235-stcrozdw 655 9 chains chain NNS cord-020235-stcrozdw 655 10 of of IN cord-020235-stcrozdw 655 11 both both CC cord-020235-stcrozdw 655 12 the the DT cord-020235-stcrozdw 655 13 complex complex JJ cord-020235-stcrozdw 655 14 type type NN cord-020235-stcrozdw 655 15 I -PRON- PRP cord-020235-stcrozdw 655 16 and and CC cord-020235-stcrozdw 655 17 the the DT cord-020235-stcrozdw 655 18 mannose mannose NN cord-020235-stcrozdw 655 19 - - HYPH cord-020235-stcrozdw 655 20 rich rich JJ cord-020235-stcrozdw 655 21 type type NN cord-020235-stcrozdw 655 22 II II NNP cord-020235-stcrozdw 655 23 . . . cord-020235-stcrozdw 656 1 There there EX cord-020235-stcrozdw 656 2 are be VBP cord-020235-stcrozdw 656 3 distinct distinct JJ cord-020235-stcrozdw 656 4 quantitative quantitative JJ cord-020235-stcrozdw 656 5 and and CC cord-020235-stcrozdw 656 6 qualitative qualitative JJ cord-020235-stcrozdw 656 7 differences difference NNS cord-020235-stcrozdw 656 8 between between IN cord-020235-stcrozdw 656 9 the the DT cord-020235-stcrozdw 656 10 strains strain NNS cord-020235-stcrozdw 656 11 in in IN cord-020235-stcrozdw 656 12 the the DT cord-020235-stcrozdw 656 13 distribution distribution NN cord-020235-stcrozdw 656 14 of of IN cord-020235-stcrozdw 656 15 type type NN cord-020235-stcrozdw 656 16 I -PRON- PRP cord-020235-stcrozdw 656 17 and and CC cord-020235-stcrozdw 656 18 type type NN cord-020235-stcrozdw 656 19 II II NNP cord-020235-stcrozdw 656 20 side side NN cord-020235-stcrozdw 656 21 chains chain NNS cord-020235-stcrozdw 656 22 on on IN cord-020235-stcrozdw 656 23 the the DT cord-020235-stcrozdw 656 24 hemagglutinin hemagglutinin NN cord-020235-stcrozdw 656 25 fragments fragment NNS cord-020235-stcrozdw 656 26 HAl hal VBP cord-020235-stcrozdw 656 27 and and CC cord-020235-stcrozdw 656 28 HA HA NNP cord-020235-stcrozdw 656 29 2 2 CD cord-020235-stcrozdw 657 1 • • NNP cord-020235-stcrozdw 658 1 The the DT cord-020235-stcrozdw 658 2 majority majority NN cord-020235-stcrozdw 658 3 of of IN cord-020235-stcrozdw 658 4 the the DT cord-020235-stcrozdw 658 5 hemagglutinin hemagglutinin NN cord-020235-stcrozdw 658 6 oligosaccharides oligosaccharide NNS cord-020235-stcrozdw 658 7 is be VBZ cord-020235-stcrozdw 658 8 located locate VBN cord-020235-stcrozdw 658 9 on on IN cord-020235-stcrozdw 658 10 HAl HAl NNS cord-020235-stcrozdw 658 11 ' ' '' cord-020235-stcrozdw 658 12 These these DT cord-020235-stcrozdw 658 13 side side NN cord-020235-stcrozdw 658 14 chains chain NNS cord-020235-stcrozdw 658 15 are be VBP cord-020235-stcrozdw 658 16 usually usually RB cord-020235-stcrozdw 658 17 of of IN cord-020235-stcrozdw 658 18 type type NN cord-020235-stcrozdw 658 19 1 1 CD cord-020235-stcrozdw 658 20 . . . cord-020235-stcrozdw 659 1 Only only RB cord-020235-stcrozdw 659 2 the the DT cord-020235-stcrozdw 659 3 hem hem NNP cord-020235-stcrozdw 659 4 agglutinins agglutinin NNS cord-020235-stcrozdw 659 5 of of IN cord-020235-stcrozdw 659 6 serotype serotype NN cord-020235-stcrozdw 659 7 H3 H3 NNP cord-020235-stcrozdw 659 8 have have VBP cord-020235-stcrozdw 659 9 , , , cord-020235-stcrozdw 659 10 in in IN cord-020235-stcrozdw 659 11 addition addition NN cord-020235-stcrozdw 659 12 , , , cord-020235-stcrozdw 659 13 a a DT cord-020235-stcrozdw 659 14 substantial substantial JJ cord-020235-stcrozdw 659 15 amount amount NN cord-020235-stcrozdw 659 16 of of IN cord-020235-stcrozdw 659 17 type type NN cord-020235-stcrozdw 659 18 II II NNP cord-020235-stcrozdw 659 19 side side NN cord-020235-stcrozdw 659 20 chains chain NNS cord-020235-stcrozdw 659 21 on on IN cord-020235-stcrozdw 659 22 HAl HAl NNPS cord-020235-stcrozdw 659 23 ' ' POS cord-020235-stcrozdw 659 24 Most Most JJS cord-020235-stcrozdw 659 25 strains strain NNS cord-020235-stcrozdw 659 26 have have VBP cord-020235-stcrozdw 659 27 on on IN cord-020235-stcrozdw 659 28 HA HA NNP cord-020235-stcrozdw 659 29 2 2 CD cord-020235-stcrozdw 659 30 a a DT cord-020235-stcrozdw 659 31 single single JJ cord-020235-stcrozdw 659 32 side side NN cord-020235-stcrozdw 659 33 chain chain NN cord-020235-stcrozdw 659 34 which which WDT cord-020235-stcrozdw 659 35 is be VBZ cord-020235-stcrozdw 659 36 usually usually RB cord-020235-stcrozdw 659 37 of of IN cord-020235-stcrozdw 659 38 type type NN cord-020235-stcrozdw 659 39 I. i. NN cord-020235-stcrozdw 659 40 With with IN cord-020235-stcrozdw 659 41 serotype serotype NN cord-020235-stcrozdw 659 42 HS HS NNP cord-020235-stcrozdw 659 43 this this DT cord-020235-stcrozdw 659 44 side side NN cord-020235-stcrozdw 659 45 chain chain NN cord-020235-stcrozdw 659 46 is be VBZ cord-020235-stcrozdw 659 47 free free JJ cord-020235-stcrozdw 659 48 of of IN cord-020235-stcrozdw 659 49 fucose fucose NNP cord-020235-stcrozdw 659 50 , , , cord-020235-stcrozdw 659 51 and and CC cord-020235-stcrozdw 659 52 with with IN cord-020235-stcrozdw 659 53 serotype serotype NN cord-020235-stcrozdw 659 54 H8 H8 NNP cord-020235-stcrozdw 659 55 it -PRON- PRP cord-020235-stcrozdw 659 56 appears appear VBZ cord-020235-stcrozdw 659 57 to to TO cord-020235-stcrozdw 659 58 be be VB cord-020235-stcrozdw 659 59 missing miss VBG cord-020235-stcrozdw 659 60 completely completely RB cord-020235-stcrozdw 659 61 . . . cord-020235-stcrozdw 660 1 Serotypes Serotypes NNP cord-020235-stcrozdw 660 2 H7 H7 NNP cord-020235-stcrozdw 660 3 and and CC cord-020235-stcrozdw 660 4 H10 H10 NNP cord-020235-stcrozdw 660 5 have have VBP cord-020235-stcrozdw 660 6 , , , cord-020235-stcrozdw 660 7 in in IN cord-020235-stcrozdw 660 8 addition addition NN cord-020235-stcrozdw 660 9 to to IN cord-020235-stcrozdw 660 10 the the DT cord-020235-stcrozdw 660 11 type type NN cord-020235-stcrozdw 660 12 I -PRON- PRP cord-020235-stcrozdw 660 13 , , , cord-020235-stcrozdw 660 14 a a DT cord-020235-stcrozdw 660 15 type type NN cord-020235-stcrozdw 660 16 II II NNP cord-020235-stcrozdw 660 17 side side NN cord-020235-stcrozdw 660 18 chain chain NN cord-020235-stcrozdw 660 19 on on IN cord-020235-stcrozdw 660 20 HA HA NNP cord-020235-stcrozdw 660 21 2 2 CD cord-020235-stcrozdw 661 1 • • NNP cord-020235-stcrozdw 662 1 These these DT cord-020235-stcrozdw 662 2 observations observation NNS cord-020235-stcrozdw 662 3 strengthen strengthen VBP cord-020235-stcrozdw 662 4 the the DT cord-020235-stcrozdw 662 5 concept concept NN cord-020235-stcrozdw 662 6 that that IN cord-020235-stcrozdw 662 7 the the DT cord-020235-stcrozdw 662 8 primary primary JJ cord-020235-stcrozdw 662 9 structure structure NN cord-020235-stcrozdw 662 10 of of IN cord-020235-stcrozdw 662 11 the the DT cord-020235-stcrozdw 662 12 polypeptide polypeptide NN cord-020235-stcrozdw 662 13 chain chain NN cord-020235-stcrozdw 662 14 is be VBZ cord-020235-stcrozdw 662 15 an an DT cord-020235-stcrozdw 662 16 important important JJ cord-020235-stcrozdw 662 17 determinant determinant NN cord-020235-stcrozdw 662 18 for for IN cord-020235-stcrozdw 662 19 the the DT cord-020235-stcrozdw 662 20 carbohydrate carbohydrate NN cord-020235-stcrozdw 662 21 moiety moiety NN cord-020235-stcrozdw 662 22 of of IN cord-020235-stcrozdw 662 23 the the DT cord-020235-stcrozdw 662 24 hemagglutinin hemagglutinin NN cord-020235-stcrozdw 662 25 . . . cord-020235-stcrozdw 663 1 Inst Inst NNP cord-020235-stcrozdw 663 2 . . . cord-020235-stcrozdw 664 1 f. f. NNP cord-020235-stcrozdw 664 2 Virologie Virologie NNP cord-020235-stcrozdw 664 3 , , , cord-020235-stcrozdw 664 4 ] ] -RRB- cord-020235-stcrozdw 664 5 ustus ustus NNP cord-020235-stcrozdw 664 6 - - HYPH cord-020235-stcrozdw 664 7 Liebig Liebig NNP cord-020235-stcrozdw 664 8 - - HYPH cord-020235-stcrozdw 664 9 Univ Univ NNP cord-020235-stcrozdw 664 10 . . . cord-020235-stcrozdw 665 1 , , , cord-020235-stcrozdw 665 2 D-6300 d-6300 CD cord-020235-stcrozdw 665 3 Giessen Giessen NNP cord-020235-stcrozdw 665 4 Acylation Acylation NNP cord-020235-stcrozdw 665 5 of of IN cord-020235-stcrozdw 665 6 Viral Viral NNP cord-020235-stcrozdw 665 7 Glycoproteins Glycoproteins NNP cord-020235-stcrozdw 665 8 SCHMIDT SCHMIDT NNP cord-020235-stcrozdw 665 9 , , , cord-020235-stcrozdw 665 10 M. M. NNP cord-020235-stcrozdw 665 11 F. F. NNP cord-020235-stcrozdw 665 12 G. G. NNP cord-020235-stcrozdw 665 13 Covalent Covalent NNP cord-020235-stcrozdw 665 14 binding binding NN cord-020235-stcrozdw 665 15 of of IN cord-020235-stcrozdw 665 16 fatty fatty JJ cord-020235-stcrozdw 665 17 acids acid NNS cord-020235-stcrozdw 665 18 to to IN cord-020235-stcrozdw 665 19 viral viral JJ cord-020235-stcrozdw 665 20 glycoproteins glycoprotein NNS cord-020235-stcrozdw 665 21 was be VBD cord-020235-stcrozdw 665 22 first first RB cord-020235-stcrozdw 665 23 detected detect VBN cord-020235-stcrozdw 665 24 with with IN cord-020235-stcrozdw 665 25 Sindbis Sindbis NNP cord-020235-stcrozdw 665 26 virus virus NN cord-020235-stcrozdw 665 27 and and CC cord-020235-stcrozdw 665 28 vesicular vesicular JJ cord-020235-stcrozdw 665 29 stomatitis stomatitis NN cord-020235-stcrozdw 665 30 virus virus NN cord-020235-stcrozdw 665 31 ( ( -LRB- cord-020235-stcrozdw 665 32 1 1 CD cord-020235-stcrozdw 665 33 , , , cord-020235-stcrozdw 665 34 2 2 CD cord-020235-stcrozdw 665 35 ) ) -RRB- cord-020235-stcrozdw 665 36 . . . cord-020235-stcrozdw 666 1 Studies study NNS cord-020235-stcrozdw 666 2 on on IN cord-020235-stcrozdw 666 3 acylation acylation NN cord-020235-stcrozdw 666 4 in in IN cord-020235-stcrozdw 666 5 other other JJ cord-020235-stcrozdw 666 6 enveloped envelop VBN cord-020235-stcrozdw 666 7 viruses virus NNS cord-020235-stcrozdw 666 8 revealed reveal VBD cord-020235-stcrozdw 666 9 that that IN cord-020235-stcrozdw 666 10 covalent covalent JJ cord-020235-stcrozdw 666 11 addition addition NN cord-020235-stcrozdw 666 12 of of IN cord-020235-stcrozdw 666 13 fatty fatty JJ cord-020235-stcrozdw 666 14 acid acid NN cord-020235-stcrozdw 666 15 to to IN cord-020235-stcrozdw 666 16 spike spike NN cord-020235-stcrozdw 666 17 glycoproteins glycoprotein NNS cord-020235-stcrozdw 666 18 is be VBZ cord-020235-stcrozdw 666 19 a a DT cord-020235-stcrozdw 666 20 more more RBR cord-020235-stcrozdw 666 21 general general JJ cord-020235-stcrozdw 666 22 feature feature NN cord-020235-stcrozdw 666 23 . . . cord-020235-stcrozdw 667 1 While while IN cord-020235-stcrozdw 667 2 in in IN cord-020235-stcrozdw 667 3 Sindbis Sindbis NNP cord-020235-stcrozdw 667 4 and and CC cord-020235-stcrozdw 667 5 in in IN cord-020235-stcrozdw 667 6 Semliki Semliki NNP cord-020235-stcrozdw 667 7 Forest Forest NNP cord-020235-stcrozdw 667 8 virus virus NN cord-020235-stcrozdw 667 9 both both DT cord-020235-stcrozdw 667 10 species specie NNS cord-020235-stcrozdw 667 11 of of IN cord-020235-stcrozdw 667 12 spike spike NN cord-020235-stcrozdw 667 13 glycoprotein glycoprotein NN cord-020235-stcrozdw 667 14 ( ( -LRB- cord-020235-stcrozdw 667 15 El El NNP cord-020235-stcrozdw 667 16 and and CC cord-020235-stcrozdw 667 17 E2 E2 NNP cord-020235-stcrozdw 667 18 ) ) -RRB- cord-020235-stcrozdw 667 19 carry carry VBP cord-020235-stcrozdw 667 20 fatty fatty JJ cord-020235-stcrozdw 667 21 acid acid NN cord-020235-stcrozdw 667 22 chains chain NNS cord-020235-stcrozdw 667 23 , , , cord-020235-stcrozdw 667 24 acylation acylation NN cord-020235-stcrozdw 667 25 with with IN cord-020235-stcrozdw 667 26 the the DT cord-020235-stcrozdw 667 27 other other JJ cord-020235-stcrozdw 667 28 viruses virus NNS cord-020235-stcrozdw 667 29 studied study VBD cord-020235-stcrozdw 667 30 ( ( -LRB- cord-020235-stcrozdw 667 31 corona- corona- JJ cord-020235-stcrozdw 667 32 , , , cord-020235-stcrozdw 667 33 influenza influenza NN cord-020235-stcrozdw 667 34 A A NNP cord-020235-stcrozdw 667 35 - - : cord-020235-stcrozdw 667 36 and and CC cord-020235-stcrozdw 667 37 paramyxovirus paramyxovirus JJ cord-020235-stcrozdw 667 38 family family NN cord-020235-stcrozdw 667 39 ) ) -RRB- cord-020235-stcrozdw 667 40 seems seem VBZ cord-020235-stcrozdw 667 41 restricted restricted JJ cord-020235-stcrozdw 667 42 to to IN cord-020235-stcrozdw 667 43 those those DT cord-020235-stcrozdw 667 44 glycoproteins glycoprotein NNS cord-020235-stcrozdw 667 45 that that WDT cord-020235-stcrozdw 667 46 are be VBP cord-020235-stcrozdw 667 47 known know VBN cord-020235-stcrozdw 667 48 to to TO cord-020235-stcrozdw 667 49 carry carry VB cord-020235-stcrozdw 667 50 fusion fusion NN cord-020235-stcrozdw 667 51 activity activity NN cord-020235-stcrozdw 667 52 . . . cord-020235-stcrozdw 668 1 This this DT cord-020235-stcrozdw 668 2 new new JJ cord-020235-stcrozdw 668 3 type type NN cord-020235-stcrozdw 668 4 of of IN cord-020235-stcrozdw 668 5 modification modification NN cord-020235-stcrozdw 668 6 of of IN cord-020235-stcrozdw 668 7 viral viral JJ cord-020235-stcrozdw 668 8 glycoproteins glycoprotein NNS cord-020235-stcrozdw 668 9 occurs occur VBZ cord-020235-stcrozdw 668 10 in in IN cord-020235-stcrozdw 668 11 a a DT cord-020235-stcrozdw 668 12 wide wide JJ cord-020235-stcrozdw 668 13 variety variety NN cord-020235-stcrozdw 668 14 of of IN cord-020235-stcrozdw 668 15 host host NN cord-020235-stcrozdw 668 16 cells cell NNS cord-020235-stcrozdw 668 17 including include VBG cord-020235-stcrozdw 668 18 those those DT cord-020235-stcrozdw 668 19 of of IN cord-020235-stcrozdw 668 20 human human JJ cord-020235-stcrozdw 668 21 , , , cord-020235-stcrozdw 668 22 bovine bovine JJ cord-020235-stcrozdw 668 23 , , , cord-020235-stcrozdw 668 24 mouse mouse NN cord-020235-stcrozdw 668 25 , , , cord-020235-stcrozdw 668 26 hamster hamster NN cord-020235-stcrozdw 668 27 , , , cord-020235-stcrozdw 668 28 avian avian JJ cord-020235-stcrozdw 668 29 and and CC cord-020235-stcrozdw 668 30 insect insect NN cord-020235-stcrozdw 668 31 origin origin NN cord-020235-stcrozdw 668 32 ( ( -LRB- cord-020235-stcrozdw 668 33 3 3 CD cord-020235-stcrozdw 668 34 ) ) -RRB- cord-020235-stcrozdw 668 35 . . . cord-020235-stcrozdw 669 1 -With -with XX cord-020235-stcrozdw 670 1 the the DT cord-020235-stcrozdw 670 2 aid aid NN cord-020235-stcrozdw 670 3 of of IN cord-020235-stcrozdw 670 4 controlled control VBN cord-020235-stcrozdw 670 5 digestion digestion NN cord-020235-stcrozdw 670 6 of of IN cord-020235-stcrozdw 670 7 3H 3h CD cord-020235-stcrozdw 670 8 - - HYPH cord-020235-stcrozdw 670 9 palmitic palmitic JJ cord-020235-stcrozdw 670 10 acid acid NN cord-020235-stcrozdw 670 11 labelled label VBN cord-020235-stcrozdw 670 12 virus virus NN cord-020235-stcrozdw 670 13 particles particle NNS cord-020235-stcrozdw 670 14 and and CC cord-020235-stcrozdw 670 15 by by IN cord-020235-stcrozdw 670 16 the the DT cord-020235-stcrozdw 670 17 analysis analysis NN cord-020235-stcrozdw 670 18 of of IN cord-020235-stcrozdw 670 19 cyanogen cyanogen NN cord-020235-stcrozdw 670 20 bromide bromide NN cord-020235-stcrozdw 670 21 fragments fragment NNS cord-020235-stcrozdw 670 22 of of IN cord-020235-stcrozdw 670 23 fatty fatty JJ cord-020235-stcrozdw 670 24 acid acid NN cord-020235-stcrozdw 670 25 labelled label VBN cord-020235-stcrozdw 670 26 glycoprotein glycoprotein NN cord-020235-stcrozdw 671 1 the the DT cord-020235-stcrozdw 671 2 fatty fatty JJ cord-020235-stcrozdw 671 3 acid acid NN cord-020235-stcrozdw 671 4 bind bind VBP cord-020235-stcrozdw 671 5 ing ing DT cord-020235-stcrozdw 671 6 site site NN cord-020235-stcrozdw 671 7 in in IN cord-020235-stcrozdw 671 8 influenza influenza NN cord-020235-stcrozdw 671 9 hemagglutinin hemagglutinin NNS cord-020235-stcrozdw 671 10 ( ( -LRB- cord-020235-stcrozdw 671 11 HAt HAt NNP cord-020235-stcrozdw 671 12 ) ) -RRB- cord-020235-stcrozdw 671 13 , , , cord-020235-stcrozdw 671 14 VSV VSV NNP cord-020235-stcrozdw 671 15 G G NNP cord-020235-stcrozdw 671 16 - - HYPH cord-020235-stcrozdw 671 17 protein protein NN cord-020235-stcrozdw 671 18 and and CC cord-020235-stcrozdw 671 19 Sindbis Sindbis NNP cord-020235-stcrozdw 671 20 virus virus NN cord-020235-stcrozdw 671 21 E1 e1 NN cord-020235-stcrozdw 671 22 and and CC cord-020235-stcrozdw 671 23 E2 E2 NNP cord-020235-stcrozdw 671 24 could could MD cord-020235-stcrozdw 671 25 be be VB cord-020235-stcrozdw 671 26 located locate VBN cord-020235-stcrozdw 671 27 to to IN cord-020235-stcrozdw 671 28 the the DT cord-020235-stcrozdw 671 29 membrane membrane NN cord-020235-stcrozdw 671 30 spanning span VBG cord-020235-stcrozdw 671 31 portion portion NN cord-020235-stcrozdw 671 32 of of IN cord-020235-stcrozdw 671 33 the the DT cord-020235-stcrozdw 671 34 respective respective JJ cord-020235-stcrozdw 671 35 proteins protein NNS cord-020235-stcrozdw 671 36 ( ( -LRB- cord-020235-stcrozdw 671 37 3 3 CD cord-020235-stcrozdw 671 38 ) ) -RRB- cord-020235-stcrozdw 671 39 . . . cord-020235-stcrozdw 672 1 Heinrich Heinrich NNP cord-020235-stcrozdw 672 2 - - HYPH cord-020235-stcrozdw 672 3 Pette Pette NNP cord-020235-stcrozdw 672 4 - - HYPH cord-020235-stcrozdw 672 5 Institut Institut NNP cord-020235-stcrozdw 672 6 f. f. NN cord-020235-stcrozdw 672 7 Exp Exp NNP cord-020235-stcrozdw 672 8 . . . cord-020235-stcrozdw 673 1 Virologie Virologie NNP cord-020235-stcrozdw 674 1 u. u. NNP cord-020235-stcrozdw 674 2 Immunologie Immunologie NNP cord-020235-stcrozdw 675 1 an an DT cord-020235-stcrozdw 675 2 d. d. NNP cord-020235-stcrozdw 675 3 Univ Univ NNP cord-020235-stcrozdw 675 4 . . . cord-020235-stcrozdw 676 1 , , , cord-020235-stcrozdw 676 2 Martinistr Martinistr NNP cord-020235-stcrozdw 676 3 . . . cord-020235-stcrozdw 677 1 52 52 CD cord-020235-stcrozdw 677 2 , , , cord-020235-stcrozdw 677 3 D-2000 d-2000 CD cord-020235-stcrozdw 678 1 Hamburg Hamburg NNP cord-020235-stcrozdw 678 2 20 20 CD cord-020235-stcrozdw 678 3 _SP cord-020235-stcrozdw 678 4 MANNWEILER MANNWEILER NNP cord-020235-stcrozdw 678 5 , , , cord-020235-stcrozdw 678 6 K. K. NNP cord-020235-stcrozdw 678 7 , , , cord-020235-stcrozdw 678 8 BOHN BOHN NNP cord-020235-stcrozdw 678 9 , , , cord-020235-stcrozdw 678 10 W. W. NNP cord-020235-stcrozdw 678 11 , , , cord-020235-stcrozdw 678 12 RUTTER RUTTER NNP cord-020235-stcrozdw 678 13 , , , cord-020235-stcrozdw 678 14 G. G. NNP cord-020235-stcrozdw 678 15 , , , cord-020235-stcrozdw 678 16 and and CC cord-020235-stcrozdw 678 17 HOHENBERG HOHENBERG NNP cord-020235-stcrozdw 678 18 , , , cord-020235-stcrozdw 678 19 H. H. NNP cord-020235-stcrozdw 679 1 In in IN cord-020235-stcrozdw 679 2 replica replica RB cord-020235-stcrozdw 679 3 - - HYPH cord-020235-stcrozdw 679 4 immunocytochemical immunocytochemical JJ cord-020235-stcrozdw 679 5 ( ( -LRB- cord-020235-stcrozdw 679 6 RIC RIC NNP cord-020235-stcrozdw 679 7 ) ) -RRB- cord-020235-stcrozdw 679 8 -and -and . cord-020235-stcrozdw 679 9 ultrathin ultrathin JJ cord-020235-stcrozdw 679 10 section section NN cord-020235-stcrozdw 679 11 ( ( -LRB- cord-020235-stcrozdw 679 12 US US NNP cord-020235-stcrozdw 679 13 ) ) -RRB- cord-020235-stcrozdw 679 14 preparations preparation NNS cord-020235-stcrozdw 679 15 the the DT cord-020235-stcrozdw 679 16 ultrastructures ultrastructure NNS cord-020235-stcrozdw 679 17 of of IN cord-020235-stcrozdw 679 18 the the DT cord-020235-stcrozdw 679 19 specific specific JJ cord-020235-stcrozdw 679 20 alterations alteration NNS cord-020235-stcrozdw 679 21 and and CC cord-020235-stcrozdw 679 22 of of IN cord-020235-stcrozdw 679 23 virus virus NN cord-020235-stcrozdw 679 24 antigens antigen NNS cord-020235-stcrozdw 679 25 , , , cord-020235-stcrozdw 679 26 which which WDT cord-020235-stcrozdw 679 27 appear appear VBP cord-020235-stcrozdw 679 28 at at IN cord-020235-stcrozdw 679 29 the the DT cord-020235-stcrozdw 679 30 plasma plasma NN cord-020235-stcrozdw 679 31 membrane membrane NN cord-020235-stcrozdw 679 32 of of IN cord-020235-stcrozdw 679 33 He He NNP cord-020235-stcrozdw 679 34 La La NNP cord-020235-stcrozdw 679 35 cell cell NN cord-020235-stcrozdw 679 36 coverslip coverslip NN cord-020235-stcrozdw 679 37 cultures culture NNS cord-020235-stcrozdw 679 38 after after IN cord-020235-stcrozdw 679 39 infection infection NN cord-020235-stcrozdw 679 40 with with IN cord-020235-stcrozdw 679 41 an an DT cord-020235-stcrozdw 679 42 adapted adapt VBN cord-020235-stcrozdw 679 43 measles measles NN cord-020235-stcrozdw 679 44 virus virus NN cord-020235-stcrozdw 679 45 strain strain NN cord-020235-stcrozdw 679 46 were be VBD cord-020235-stcrozdw 679 47 investigated investigate VBN cord-020235-stcrozdw 679 48 . . . cord-020235-stcrozdw 680 1 As as IN cord-020235-stcrozdw 680 2 immunomarker immunomarker NNP cord-020235-stcrozdw 680 3 protein protein NN cord-020235-stcrozdw 680 4 A A NNP cord-020235-stcrozdw 680 5 - - HYPH cord-020235-stcrozdw 680 6 coated coated JJ cord-020235-stcrozdw 680 7 gold gold NN cord-020235-stcrozdw 680 8 particles particle NNS cord-020235-stcrozdw 680 9 were be VBD cord-020235-stcrozdw 680 10 used use VBN cord-020235-stcrozdw 680 11 ( ( -LRB- cord-020235-stcrozdw 680 12 1 1 CD cord-020235-stcrozdw 680 13 ) ) -RRB- cord-020235-stcrozdw 680 14 . . . cord-020235-stcrozdw 681 1 This this DT cord-020235-stcrozdw 681 2 method method NN cord-020235-stcrozdw 681 3 is be VBZ cord-020235-stcrozdw 681 4 sufficiently sufficiently RB cord-020235-stcrozdw 681 5 sensitive sensitive JJ cord-020235-stcrozdw 681 6 to to TO cord-020235-stcrozdw 681 7 enable enable VB cord-020235-stcrozdw 681 8 labeling labeling NN cord-020235-stcrozdw 681 9 of of IN cord-020235-stcrozdw 681 10 even even RB cord-020235-stcrozdw 681 11 small small JJ cord-020235-stcrozdw 681 12 altered alter VBN cord-020235-stcrozdw 681 13 areas area NNS cord-020235-stcrozdw 681 14 of of IN cord-020235-stcrozdw 681 15 the the DT cord-020235-stcrozdw 681 16 plasma plasma NN cord-020235-stcrozdw 681 17 membrane membrane NN cord-020235-stcrozdw 681 18 ( ( -LRB- cord-020235-stcrozdw 681 19 70 70 CD cord-020235-stcrozdw 681 20 - - SYM cord-020235-stcrozdw 681 21 100 100 CD cord-020235-stcrozdw 681 22 nm nm NN cord-020235-stcrozdw 681 23 Cb Cb NNP cord-020235-stcrozdw 681 24 ) ) -RRB- cord-020235-stcrozdw 681 25 . . . cord-020235-stcrozdw 682 1 Due due IN cord-020235-stcrozdw 682 2 to to IN cord-020235-stcrozdw 682 3 the the DT cord-020235-stcrozdw 682 4 high high JJ cord-020235-stcrozdw 682 5 atomic atomic JJ cord-020235-stcrozdw 682 6 number number NN cord-020235-stcrozdw 682 7 contrast contrast NN cord-020235-stcrozdw 682 8 in in IN cord-020235-stcrozdw 682 9 the the DT cord-020235-stcrozdw 682 10 TEM tem NN cord-020235-stcrozdw 682 11 and and CC cord-020235-stcrozdw 682 12 the the DT cord-020235-stcrozdw 682 13 small small JJ cord-020235-stcrozdw 682 14 size size NN cord-020235-stcrozdw 682 15 of of IN cord-020235-stcrozdw 682 16 the the DT cord-020235-stcrozdw 682 17 marker marker NN cord-020235-stcrozdw 682 18 ( ( -LRB- cord-020235-stcrozdw 682 19 - - : cord-020235-stcrozdw 682 20 < < XX cord-020235-stcrozdw 682 21 : : : cord-020235-stcrozdw 682 22 : : : cord-020235-stcrozdw 682 23 10 10 CD cord-020235-stcrozdw 682 24 nm nm NN cord-020235-stcrozdw 682 25 ) ) -RRB- cord-020235-stcrozdw 683 1 the the DT cord-020235-stcrozdw 683 2 ultrastructure ultrastructure NN cord-020235-stcrozdw 683 3 of of IN cord-020235-stcrozdw 683 4 characteristic characteristic JJ cord-020235-stcrozdw 683 5 alterations alteration NNS cord-020235-stcrozdw 683 6 morphologically morphologically RB cord-020235-stcrozdw 683 7 still still RB cord-020235-stcrozdw 683 8 remains remain VBZ cord-020235-stcrozdw 683 9 visible visible JJ cord-020235-stcrozdw 683 10 with with IN cord-020235-stcrozdw 683 11 ease ease NN cord-020235-stcrozdw 683 12 in in IN cord-020235-stcrozdw 683 13 a a DT cord-020235-stcrozdw 683 14 three three CD cord-020235-stcrozdw 683 15 - - HYPH cord-020235-stcrozdw 683 16 dimensional dimensional JJ cord-020235-stcrozdw 683 17 aspect aspect NN cord-020235-stcrozdw 683 18 . . . cord-020235-stcrozdw 684 1 Data datum NNS cord-020235-stcrozdw 684 2 obtained obtain VBN cord-020235-stcrozdw 684 3 by by IN cord-020235-stcrozdw 684 4 RIC RIC NNP cord-020235-stcrozdw 684 5 and and CC cord-020235-stcrozdw 684 6 US US NNP cord-020235-stcrozdw 684 7 preparations preparation NNS cord-020235-stcrozdw 684 8 after after IN cord-020235-stcrozdw 684 9 labeling label VBG cord-020235-stcrozdw 684 10 with with IN cord-020235-stcrozdw 684 11 antimeasles antimeasles NNP cord-020235-stcrozdw 684 12 immune immune JJ cord-020235-stcrozdw 684 13 serum serum NN cord-020235-stcrozdw 684 14 or or CC cord-020235-stcrozdw 684 15 with with IN cord-020235-stcrozdw 684 16 monoclonal monoclonal JJ cord-020235-stcrozdw 684 17 antibodies antibody NNS cord-020235-stcrozdw 684 18 against against IN cord-020235-stcrozdw 684 19 HA HA NNP cord-020235-stcrozdw 684 20 ( ( -LRB- cord-020235-stcrozdw 684 21 2 2 LS cord-020235-stcrozdw 684 22 ) ) -RRB- cord-020235-stcrozdw 684 23 are be VBP cord-020235-stcrozdw 684 24 demonstrated demonstrate VBN cord-020235-stcrozdw 684 25 , , , cord-020235-stcrozdw 684 26 compared compare VBN cord-020235-stcrozdw 684 27 and and CC cord-020235-stcrozdw 684 28 discussed discuss VBN cord-020235-stcrozdw 684 29 . . . cord-020235-stcrozdw 685 1 BOHN BOHN NNP cord-020235-stcrozdw 685 2 , , , cord-020235-stcrozdw 685 3 W. W. NNP cord-020235-stcrozdw 685 4 , , , cord-020235-stcrozdw 685 5 RUTTER RUTTER NNP cord-020235-stcrozdw 685 6 , , , cord-020235-stcrozdw 685 7 G. G. NNP cord-020235-stcrozdw 685 8 , , , cord-020235-stcrozdw 685 9 and and CC cord-020235-stcrozdw 685 10 MANNWEILER MANNWEILER NNP cord-020235-stcrozdw 685 11 , , , cord-020235-stcrozdw 685 12 K. K. NNP cord-020235-stcrozdw 686 1 By by IN cord-020235-stcrozdw 686 2 use use NN cord-020235-stcrozdw 686 3 of of IN cord-020235-stcrozdw 686 4 the the DT cord-020235-stcrozdw 686 5 mouse mouse NN cord-020235-stcrozdw 686 6 hybridoma hybridoma NN cord-020235-stcrozdw 686 7 technique technique NN cord-020235-stcrozdw 686 8 , , , cord-020235-stcrozdw 686 9 monoclonal monoclonal JJ cord-020235-stcrozdw 686 10 antibodies antibody NNS cord-020235-stcrozdw 686 11 were be VBD cord-020235-stcrozdw 686 12 obtained obtain VBN cord-020235-stcrozdw 686 13 with with IN cord-020235-stcrozdw 686 14 specificity specificity NN cord-020235-stcrozdw 686 15 for for IN cord-020235-stcrozdw 686 16 the the DT cord-020235-stcrozdw 686 17 HA HA NNP cord-020235-stcrozdw 686 18 ( ( -LRB- cord-020235-stcrozdw 686 19 79 79 CD cord-020235-stcrozdw 686 20 K K NNP cord-020235-stcrozdw 686 21 ) ) -RRB- cord-020235-stcrozdw 686 22 , , , cord-020235-stcrozdw 686 23 P p NN cord-020235-stcrozdw 686 24 ( ( -LRB- cord-020235-stcrozdw 686 25 72 72 CD cord-020235-stcrozdw 686 26 K K NNP cord-020235-stcrozdw 686 27 ) ) -RRB- cord-020235-stcrozdw 686 28 and and CC cord-020235-stcrozdw 686 29 M M NNP cord-020235-stcrozdw 686 30 ( ( -LRB- cord-020235-stcrozdw 686 31 36 36 CD cord-020235-stcrozdw 686 32 K k NN cord-020235-stcrozdw 686 33 ) ) -RRB- cord-020235-stcrozdw 686 34 polypeptides polypeptide NNS cord-020235-stcrozdw 686 35 of of IN cord-020235-stcrozdw 686 36 measles measle NNS cord-020235-stcrozdw 686 37 virus virus NN cord-020235-stcrozdw 686 38 . . . cord-020235-stcrozdw 687 1 Balblc Balblc NNP cord-020235-stcrozdw 687 2 mice mouse NNS cord-020235-stcrozdw 687 3 were be VBD cord-020235-stcrozdw 687 4 immunized immunize VBN cord-020235-stcrozdw 687 5 with with IN cord-020235-stcrozdw 687 6 native native JJ cord-020235-stcrozdw 687 7 measles measle NNS cord-020235-stcrozdw 687 8 virus virus NN cord-020235-stcrozdw 687 9 and and CC cord-020235-stcrozdw 687 10 measles measles NN cord-020235-stcrozdw 687 11 virus virus NN cord-020235-stcrozdw 687 12 treated treat VBN cord-020235-stcrozdw 687 13 with with IN cord-020235-stcrozdw 687 14 detergents detergent NNS cord-020235-stcrozdw 687 15 and and CC cord-020235-stcrozdw 687 16 heat heat NN cord-020235-stcrozdw 687 17 . . . cord-020235-stcrozdw 688 1 Clones clone NNS cord-020235-stcrozdw 688 2 obtained obtain VBN cord-020235-stcrozdw 688 3 after after IN cord-020235-stcrozdw 688 4 immunization immunization NN cord-020235-stcrozdw 688 5 of of IN cord-020235-stcrozdw 688 6 mice mouse NNS cord-020235-stcrozdw 688 7 with with IN cord-020235-stcrozdw 688 8 native native JJ cord-020235-stcrozdw 688 9 measles measle NNS cord-020235-stcrozdw 688 10 virus virus NN cord-020235-stcrozdw 689 1 showed show VBD cord-020235-stcrozdw 689 2 specificity specificity NN cord-020235-stcrozdw 689 3 for for IN cord-020235-stcrozdw 689 4 the the DT cord-020235-stcrozdw 689 5 HA HA NNP cord-020235-stcrozdw 689 6 polypeptide polypeptide NN cord-020235-stcrozdw 689 7 only only RB cord-020235-stcrozdw 689 8 . . . cord-020235-stcrozdw 690 1 After after IN cord-020235-stcrozdw 690 2 immunization immunization NN cord-020235-stcrozdw 690 3 with with IN cord-020235-stcrozdw 690 4 measles measle NNS cord-020235-stcrozdw 690 5 virus virus NN cord-020235-stcrozdw 690 6 , , , cord-020235-stcrozdw 690 7 treated treat VBN cord-020235-stcrozdw 690 8 with with IN cord-020235-stcrozdw 690 9 1 1 CD cord-020235-stcrozdw 690 10 0/0 0/0 CD cord-020235-stcrozdw 690 11 sodium sodium NN cord-020235-stcrozdw 690 12 sarkosyl sarkosyl NN cord-020235-stcrozdw 690 13 sulfate sulfate NN cord-020235-stcrozdw 690 14 ( ( -LRB- cord-020235-stcrozdw 690 15 SSS SSS NNP cord-020235-stcrozdw 690 16 ) ) -RRB- cord-020235-stcrozdw 690 17 at at IN cord-020235-stcrozdw 690 18 20 20 CD cord-020235-stcrozdw 690 19 ° ° NN cord-020235-stcrozdw 690 20 C C NNP cord-020235-stcrozdw 690 21 a a DT cord-020235-stcrozdw 690 22 clone clone NN cord-020235-stcrozdw 690 23 was be VBD cord-020235-stcrozdw 690 24 obtained obtain VBN cord-020235-stcrozdw 690 25 producing produce VBG cord-020235-stcrozdw 690 26 antibodies antibody NNS cord-020235-stcrozdw 690 27 to to IN cord-020235-stcrozdw 690 28 the the DT cord-020235-stcrozdw 690 29 M M NNP cord-020235-stcrozdw 690 30 polypeptide polypeptide NN cord-020235-stcrozdw 690 31 . . . cord-020235-stcrozdw 691 1 Heating heating NN cord-020235-stcrozdw 691 2 of of IN cord-020235-stcrozdw 691 3 measles measle NNS cord-020235-stcrozdw 691 4 virus virus NN cord-020235-stcrozdw 691 5 in in IN cord-020235-stcrozdw 691 6 the the DT cord-020235-stcrozdw 691 7 presence presence NN cord-020235-stcrozdw 691 8 of of IN cord-020235-stcrozdw 691 9 1 1 CD cord-020235-stcrozdw 691 10 0/0 0/0 CD cord-020235-stcrozdw 691 11 SDS sds NN cord-020235-stcrozdw 691 12 under under IN cord-020235-stcrozdw 691 13 reducing reduce VBG cord-020235-stcrozdw 691 14 conditions condition NNS cord-020235-stcrozdw 691 15 elicited elicit VBD cord-020235-stcrozdw 691 16 a a DT cord-020235-stcrozdw 691 17 selective selective JJ cord-020235-stcrozdw 691 18 immune immune JJ cord-020235-stcrozdw 691 19 response response NN cord-020235-stcrozdw 691 20 to to IN cord-020235-stcrozdw 691 21 the the DT cord-020235-stcrozdw 691 22 P P NNP cord-020235-stcrozdw 691 23 and and CC cord-020235-stcrozdw 691 24 NP NP NNP cord-020235-stcrozdw 691 25 polypeptides polypeptide NNS cord-020235-stcrozdw 691 26 . . . cord-020235-stcrozdw 692 1 Thus thus RB cord-020235-stcrozdw 692 2 , , , cord-020235-stcrozdw 692 3 clones clone NNS cord-020235-stcrozdw 692 4 producing produce VBG cord-020235-stcrozdw 692 5 antibodies antibody NNS cord-020235-stcrozdw 692 6 to to IN cord-020235-stcrozdw 692 7 the the DT cord-020235-stcrozdw 692 8 P p NN cord-020235-stcrozdw 692 9 polypeptides polypeptide NNS cord-020235-stcrozdw 692 10 were be VBD cord-020235-stcrozdw 692 11 isolated isolate VBN cord-020235-stcrozdw 692 12 . . . cord-020235-stcrozdw 693 1 contains contain VBZ cord-020235-stcrozdw 693 2 a a DT cord-020235-stcrozdw 693 3 50s 50 NNS cord-020235-stcrozdw 693 4 RNA RNA NNP cord-020235-stcrozdw 693 5 , , , cord-020235-stcrozdw 693 6 but but CC cord-020235-stcrozdw 693 7 it -PRON- PRP cord-020235-stcrozdw 693 8 does do VBZ cord-020235-stcrozdw 693 9 not not RB cord-020235-stcrozdw 693 10 show show VB cord-020235-stcrozdw 693 11 any any DT cord-020235-stcrozdw 693 12 infectivity infectivity NN cord-020235-stcrozdw 693 13 even even RB cord-020235-stcrozdw 693 14 after after IN cord-020235-stcrozdw 693 15 trypsin trypsin NN cord-020235-stcrozdw 693 16 treatment treatment NN cord-020235-stcrozdw 693 17 . . . cord-020235-stcrozdw 694 1 An an DT cord-020235-stcrozdw 694 2 activation activation NN cord-020235-stcrozdw 694 3 of of IN cord-020235-stcrozdw 694 4 the the DT cord-020235-stcrozdw 694 5 6/94 6/94 CD cord-020235-stcrozdw 694 6 cl cl NNP cord-020235-stcrozdw 694 7 virus virus NN cord-020235-stcrozdw 694 8 can can MD cord-020235-stcrozdw 694 9 be be VB cord-020235-stcrozdw 694 10 obtained obtain VBN cord-020235-stcrozdw 694 11 by by IN cord-020235-stcrozdw 694 12 i i NN cord-020235-stcrozdw 694 13 ) ) -RRB- cord-020235-stcrozdw 694 14 cocultivation cocultivation NN cord-020235-stcrozdw 694 15 of of IN cord-020235-stcrozdw 694 16 the the DT cord-020235-stcrozdw 694 17 CL CL NNP cord-020235-stcrozdw 694 18 - - HYPH cord-020235-stcrozdw 694 19 E-8 E-8 NNP cord-020235-stcrozdw 694 20 cells cell NNS cord-020235-stcrozdw 694 21 with with IN cord-020235-stcrozdw 694 22 standard standard JJ cord-020235-stcrozdw 694 23 cells cell NNS cord-020235-stcrozdw 695 1 ( ( -LRB- cord-020235-stcrozdw 695 2 e. e. NNP cord-020235-stcrozdw 695 3 g. g. NNP cord-020235-stcrozdw 695 4 BHK-21 BHK-21 NNP cord-020235-stcrozdw 695 5 ) ) -RRB- cord-020235-stcrozdw 695 6 and and CC cord-020235-stcrozdw 695 7 ii ii LS cord-020235-stcrozdw 695 8 ) ) -RRB- cord-020235-stcrozdw 696 1 serial serial JJ cord-020235-stcrozdw 696 2 passaging passaging NN cord-020235-stcrozdw 696 3 of of IN cord-020235-stcrozdw 696 4 the the DT cord-020235-stcrozdw 696 5 6/94 6/94 CD cord-020235-stcrozdw 696 6 cl cl NNP cord-020235-stcrozdw 696 7 virus virus NN cord-020235-stcrozdw 696 8 in in IN cord-020235-stcrozdw 696 9 several several JJ cord-020235-stcrozdw 696 10 cell cell NN cord-020235-stcrozdw 696 11 lines line NNS cord-020235-stcrozdw 697 1 ( ( -LRB- cord-020235-stcrozdw 697 2 e. e. NNP cord-020235-stcrozdw 697 3 g. g. NNP cord-020235-stcrozdw 697 4 BSC-1 BSC-1 NNP cord-020235-stcrozdw 697 5 ) ) -RRB- cord-020235-stcrozdw 697 6 . . . cord-020235-stcrozdw 698 1 Infectious infectious JJ cord-020235-stcrozdw 698 2 6/94 6/94 CD cord-020235-stcrozdw 698 3 cl cl NNP cord-020235-stcrozdw 698 4 virus virus NN cord-020235-stcrozdw 698 5 can can MD cord-020235-stcrozdw 698 6 be be VB cord-020235-stcrozdw 698 7 detected detect VBN cord-020235-stcrozdw 698 8 in in IN cord-020235-stcrozdw 698 9 the the DT cord-020235-stcrozdw 698 10 cell cell NN cord-020235-stcrozdw 698 11 supernatant supernatant JJ cord-020235-stcrozdw 698 12 after after IN cord-020235-stcrozdw 698 13 a a DT cord-020235-stcrozdw 698 14 period period NN cord-020235-stcrozdw 698 15 of of IN cord-020235-stcrozdw 698 16 5 5 CD cord-020235-stcrozdw 698 17 - - SYM cord-020235-stcrozdw 698 18 10 10 CD cord-020235-stcrozdw 698 19 days day NNS cord-020235-stcrozdw 698 20 and and CC cord-020235-stcrozdw 698 21 25 25 CD cord-020235-stcrozdw 698 22 - - SYM cord-020235-stcrozdw 698 23 30 30 CD cord-020235-stcrozdw 698 24 days day NNS cord-020235-stcrozdw 698 25 respectively respectively RB cord-020235-stcrozdw 698 26 . . . cord-020235-stcrozdw 699 1 This this DT cord-020235-stcrozdw 699 2 virus virus NN cord-020235-stcrozdw 699 3 can can MD cord-020235-stcrozdw 699 4 not not RB cord-020235-stcrozdw 699 5 be be VB cord-020235-stcrozdw 699 6 propagated propagate VBN cord-020235-stcrozdw 699 7 in in IN cord-020235-stcrozdw 699 8 chicken chicken NN cord-020235-stcrozdw 699 9 eggs egg NNS cord-020235-stcrozdw 699 10 , , , cord-020235-stcrozdw 699 11 but but CC cord-020235-stcrozdw 699 12 it -PRON- PRP cord-020235-stcrozdw 699 13 can can MD cord-020235-stcrozdw 699 14 replicate replicate VB cord-020235-stcrozdw 699 15 in in IN cord-020235-stcrozdw 699 16 serial serial JJ cord-020235-stcrozdw 699 17 cell cell NN cord-020235-stcrozdw 699 18 cultures culture NNS cord-020235-stcrozdw 699 19 without without IN cord-020235-stcrozdw 699 20 trypsin trypsin NN cord-020235-stcrozdw 699 21 treatment treatment NN cord-020235-stcrozdw 699 22 ; ; : cord-020235-stcrozdw 699 23 moreover moreover RB cord-020235-stcrozdw 699 24 trypsin trypsin NN cord-020235-stcrozdw 699 25 treatment treatment NN cord-020235-stcrozdw 699 26 does do VBZ cord-020235-stcrozdw 699 27 not not RB cord-020235-stcrozdw 699 28 influence influence VB cord-020235-stcrozdw 699 29 the the DT cord-020235-stcrozdw 699 30 viral viral JJ cord-020235-stcrozdw 699 31 replicaiton replicaiton NN cord-020235-stcrozdw 699 32 . . . cord-020235-stcrozdw 700 1 In in IN cord-020235-stcrozdw 700 2 comparison comparison NN cord-020235-stcrozdw 700 3 6/94 6/94 CD cord-020235-stcrozdw 700 4 virus virus NN cord-020235-stcrozdw 700 5 released release VBN cord-020235-stcrozdw 700 6 from from IN cord-020235-stcrozdw 700 7 an an DT cord-020235-stcrozdw 700 8 in in IN cord-020235-stcrozdw 700 9 - - HYPH cord-020235-stcrozdw 700 10 vitro vitro FW cord-020235-stcrozdw 700 11 generated generate VBD cord-020235-stcrozdw 700 12 persistent persistent JJ cord-020235-stcrozdw 700 13 infection infection NN cord-020235-stcrozdw 700 14 ( ( -LRB- cord-020235-stcrozdw 700 15 BSC-1 bsc-1 NN cord-020235-stcrozdw 700 16 cells cell NNS cord-020235-stcrozdw 700 17 infected infect VBN cord-020235-stcrozdw 700 18 with with IN cord-020235-stcrozdw 700 19 egggrown egggrown NN cord-020235-stcrozdw 700 20 6/94 6/94 CD cord-020235-stcrozdw 700 21 standard standard JJ cord-020235-stcrozdw 700 22 virus virus NN cord-020235-stcrozdw 700 23 ) ) -RRB- cord-020235-stcrozdw 700 24 can can MD cord-020235-stcrozdw 700 25 be be VB cord-020235-stcrozdw 700 26 propagated propagate VBN cord-020235-stcrozdw 700 27 in in IN cord-020235-stcrozdw 700 28 chicken chicken NN cord-020235-stcrozdw 700 29 eggs egg NNS cord-020235-stcrozdw 700 30 . . . cord-020235-stcrozdw 701 1 This this DT cord-020235-stcrozdw 701 2 virus virus NN cord-020235-stcrozdw 701 3 termed term VBD cord-020235-stcrozdw 701 4 6/94 6/94 CD cord-020235-stcrozdw 701 5 pi pi NN cord-020235-stcrozdw 701 6 virus virus NN cord-020235-stcrozdw 701 7 also also RB cord-020235-stcrozdw 701 8 can can MD cord-020235-stcrozdw 701 9 grow grow VB cord-020235-stcrozdw 701 10 on on IN cord-020235-stcrozdw 701 11 serial serial JJ cord-020235-stcrozdw 701 12 cell cell NN cord-020235-stcrozdw 701 13 passages passage NNS cord-020235-stcrozdw 701 14 without without IN cord-020235-stcrozdw 701 15 trypsin trypsin NN cord-020235-stcrozdw 701 16 treatment treatment NN cord-020235-stcrozdw 701 17 , , , cord-020235-stcrozdw 701 18 whereas whereas IN cord-020235-stcrozdw 701 19 the the DT cord-020235-stcrozdw 701 20 serial serial JJ cord-020235-stcrozdw 701 21 replication replication NN cord-020235-stcrozdw 701 22 of of IN cord-020235-stcrozdw 701 23 6/94 6/94 CD cord-020235-stcrozdw 701 24 standard standard JJ cord-020235-stcrozdw 701 25 virus virus NN cord-020235-stcrozdw 701 26 on on IN cord-020235-stcrozdw 701 27 cell cell NN cord-020235-stcrozdw 701 28 cultures culture NNS cord-020235-stcrozdw 701 29 depends depend VBZ cord-020235-stcrozdw 701 30 on on IN cord-020235-stcrozdw 701 31 the the DT cord-020235-stcrozdw 701 32 trypsin trypsin NN cord-020235-stcrozdw 701 33 - - HYPH cord-020235-stcrozdw 701 34 activation activation NN cord-020235-stcrozdw 701 35 . . . cord-020235-stcrozdw 702 1 Inst Inst NNP cord-020235-stcrozdw 702 2 , , , cord-020235-stcrozdw 702 3 f. f. NN cord-020235-stcrozdw 702 4 Virologie Virologie NNP cord-020235-stcrozdw 702 5 u. u. NNP cord-020235-stcrozdw 702 6 Immunbiologie Immunbiologie NNP cord-020235-stcrozdw 702 7 , , , cord-020235-stcrozdw 702 8 Versbacher Versbacher NNP cord-020235-stcrozdw 702 9 Str Str NNP cord-020235-stcrozdw 702 10 . . . cord-020235-stcrozdw 703 1 7 7 CD cord-020235-stcrozdw 703 2 , , , cord-020235-stcrozdw 703 3 D-8700 d-8700 ADD cord-020235-stcrozdw 704 1 Wiirzburg Wiirzburg NNP cord-020235-stcrozdw 704 2 MONZEL MONZEL NNP cord-020235-stcrozdw 704 3 , , , cord-020235-stcrozdw 704 4 P. P. NNP cord-020235-stcrozdw 704 5 and and CC cord-020235-stcrozdw 704 6 KOSCHEL KOSCHEL NNP cord-020235-stcrozdw 704 7 , , , cord-020235-stcrozdw 705 1 K. K. NNP cord-020235-stcrozdw 706 1 The the DT cord-020235-stcrozdw 706 2 paramyxvviruses paramyxvviruse NNS cord-020235-stcrozdw 706 3 measles measle NNS cord-020235-stcrozdw 706 4 ( ( -LRB- cord-020235-stcrozdw 706 5 SSPE SSPE NNP cord-020235-stcrozdw 706 6 ) ) -RRB- cord-020235-stcrozdw 706 7 virus virus NN cord-020235-stcrozdw 706 8 and and CC cord-020235-stcrozdw 706 9 canine canine JJ cord-020235-stcrozdw 706 10 distemper distemper NN cord-020235-stcrozdw 706 11 virus virus NN cord-020235-stcrozdw 706 12 ( ( -LRB- cord-020235-stcrozdw 706 13 CDV CDV NNP cord-020235-stcrozdw 706 14 ) ) -RRB- cord-020235-stcrozdw 706 15 cause cause VB cord-020235-stcrozdw 706 16 an an DT cord-020235-stcrozdw 706 17 impairment impairment NN cord-020235-stcrozdw 706 18 of of IN cord-020235-stcrozdw 706 19 the the DT cord-020235-stcrozdw 706 20 catecholamine catecholamine NN cord-020235-stcrozdw 706 21 induced induced NN cord-020235-stcrozdw 706 22 p p NN cord-020235-stcrozdw 706 23 - - HYPH cord-020235-stcrozdw 706 24 adrenergic adrenergic NN cord-020235-stcrozdw 706 25 receptor receptor NN cord-020235-stcrozdw 707 1 dependent dependent JJ cord-020235-stcrozdw 707 2 c c NNP cord-020235-stcrozdw 707 3 - - HYPH cord-020235-stcrozdw 707 4 AMP amp NN cord-020235-stcrozdw 707 5 generation generation NN cord-020235-stcrozdw 707 6 in in IN cord-020235-stcrozdw 707 7 persistently persistently RB cord-020235-stcrozdw 707 8 infected infect VBN cord-020235-stcrozdw 707 9 C6 C6 NNP cord-020235-stcrozdw 707 10 rat rat NN cord-020235-stcrozdw 707 11 glioma glioma NN cord-020235-stcrozdw 707 12 cells cell NNS cord-020235-stcrozdw 707 13 . . . cord-020235-stcrozdw 708 1 In in IN cord-020235-stcrozdw 708 2 CDV CDV NNP cord-020235-stcrozdw 708 3 persistently persistently RB cord-020235-stcrozdw 708 4 infected infect VBD cord-020235-stcrozdw 708 5 C6 c6 NN cord-020235-stcrozdw 708 6 cells cell NNS cord-020235-stcrozdw 708 7 the the DT cord-020235-stcrozdw 708 8 number number NN cord-020235-stcrozdw 708 9 of of IN cord-020235-stcrozdw 708 10 receptors receptor NNS cord-020235-stcrozdw 708 11 is be VBZ cord-020235-stcrozdw 708 12 greatly greatly RB cord-020235-stcrozdw 708 13 reduced reduce VBN cord-020235-stcrozdw 708 14 . . . cord-020235-stcrozdw 709 1 Hirata Hirata NNP cord-020235-stcrozdw 709 2 and and CC cord-020235-stcrozdw 709 3 Axelrod Axelrod NNP cord-020235-stcrozdw 709 4 have have VBP cord-020235-stcrozdw 709 5 shown show VBN cord-020235-stcrozdw 709 6 that that IN cord-020235-stcrozdw 709 7 the the DT cord-020235-stcrozdw 709 8 number number NN cord-020235-stcrozdw 709 9 of of IN cord-020235-stcrozdw 709 10 Ii Ii NNP cord-020235-stcrozdw 709 11 - - HYPH cord-020235-stcrozdw 709 12 adrenergic adrenergic JJ cord-020235-stcrozdw 709 13 receptors receptor NNS cord-020235-stcrozdw 709 14 could could MD cord-020235-stcrozdw 709 15 be be VB cord-020235-stcrozdw 709 16 regulated regulate VBN cord-020235-stcrozdw 709 17 by by IN cord-020235-stcrozdw 709 18 methylation methylation NN cord-020235-stcrozdw 709 19 of of IN cord-020235-stcrozdw 709 20 phosphatidyl phosphatidyl NNP cord-020235-stcrozdw 709 21 ethanolamine ethanolamine NNP cord-020235-stcrozdw 709 22 ( ( -LRB- cord-020235-stcrozdw 709 23 PE PE NNP cord-020235-stcrozdw 709 24 ) ) -RRB- cord-020235-stcrozdw 709 25 resulting result VBG cord-020235-stcrozdw 709 26 in in IN cord-020235-stcrozdw 709 27 lecithin lecithin NN cord-020235-stcrozdw 709 28 synthesis synthesis NN cord-020235-stcrozdw 709 29 ( ( -LRB- cord-020235-stcrozdw 709 30 1 1 CD cord-020235-stcrozdw 709 31 ) ) -RRB- cord-020235-stcrozdw 709 32 . . . cord-020235-stcrozdw 710 1 We -PRON- PRP cord-020235-stcrozdw 710 2 have have VBP cord-020235-stcrozdw 710 3 therefore therefore RB cord-020235-stcrozdw 710 4 studied study VBN cord-020235-stcrozdw 710 5 the the DT cord-020235-stcrozdw 710 6 methylation methylation NN cord-020235-stcrozdw 710 7 of of IN cord-020235-stcrozdw 710 8 PE PE NNP cord-020235-stcrozdw 710 9 in in IN cord-020235-stcrozdw 710 10 persistently persistently RB cord-020235-stcrozdw 710 11 infected infect VBN cord-020235-stcrozdw 710 12 cells cell NNS cord-020235-stcrozdw 710 13 by by IN cord-020235-stcrozdw 710 14 the the DT cord-020235-stcrozdw 710 15 incorporation incorporation NN cord-020235-stcrozdw 710 16 of of IN cord-020235-stcrozdw 710 17 ( ( -LRB- cord-020235-stcrozdw 710 18 3H 3h NN cord-020235-stcrozdw 710 19 ) ) -RRB- cord-020235-stcrozdw 710 20 methyl methyl NN cord-020235-stcrozdw 710 21 groups group NNS cord-020235-stcrozdw 710 22 from from IN cord-020235-stcrozdw 710 23 ( ( -LRB- cord-020235-stcrozdw 710 24 3H 3H NNP cord-020235-stcrozdw 710 25 - - : cord-020235-stcrozdw 710 26 methyl)-Methionine methyl)-Methionine NNP cord-020235-stcrozdw 710 27 into into IN cord-020235-stcrozdw 710 28 PE PE NNP cord-020235-stcrozdw 710 29 . . . cord-020235-stcrozdw 711 1 In in IN cord-020235-stcrozdw 711 2 both both DT cord-020235-stcrozdw 711 3 infected infected JJ cord-020235-stcrozdw 711 4 systems system NNS cord-020235-stcrozdw 711 5 , , , cord-020235-stcrozdw 711 6 C6 C6 NNP cord-020235-stcrozdw 711 7 / / SYM cord-020235-stcrozdw 711 8 SSPE SSPE NNP cord-020235-stcrozdw 711 9 and and CC cord-020235-stcrozdw 711 10 C6 C6 NNP cord-020235-stcrozdw 711 11 / / SYM cord-020235-stcrozdw 711 12 CDV CDV NNP cord-020235-stcrozdw 711 13 , , , cord-020235-stcrozdw 711 14 we -PRON- PRP cord-020235-stcrozdw 711 15 observed observe VBD cord-020235-stcrozdw 711 16 a a DT cord-020235-stcrozdw 711 17 total total JJ cord-020235-stcrozdw 711 18 loss loss NN cord-020235-stcrozdw 711 19 of of IN cord-020235-stcrozdw 711 20 catecholamine catecholamine NN cord-020235-stcrozdw 711 21 stimulated stimulate VBN cord-020235-stcrozdw 711 22 p p NN cord-020235-stcrozdw 711 23 - - HYPH cord-020235-stcrozdw 711 24 adrenergic adrenergic NN cord-020235-stcrozdw 711 25 receptor receptor NN cord-020235-stcrozdw 711 26 dependent dependent JJ cord-020235-stcrozdw 711 27 methylation methylation NN cord-020235-stcrozdw 711 28 whereas whereas IN cord-020235-stcrozdw 711 29 the the DT cord-020235-stcrozdw 711 30 p p NN cord-020235-stcrozdw 711 31 - - HYPH cord-020235-stcrozdw 711 32 receptor receptor NN cord-020235-stcrozdw 711 33 independent independent JJ cord-020235-stcrozdw 711 34 methylation methylation NN cord-020235-stcrozdw 711 35 of of IN cord-020235-stcrozdw 711 36 phospholipids phospholipid NNS cord-020235-stcrozdw 711 37 is be VBZ cord-020235-stcrozdw 711 38 unchanged unchanged JJ cord-020235-stcrozdw 711 39 . . . cord-020235-stcrozdw 712 1 Inst Inst NNP cord-020235-stcrozdw 712 2 . . . cord-020235-stcrozdw 713 1 f. f. NNP cord-020235-stcrozdw 713 2 Med Med NNP cord-020235-stcrozdw 713 3 . . . cord-020235-stcrozdw 714 1 Virologie Virologie NNP cord-020235-stcrozdw 714 2 d. d. NNP cord-020235-stcrozdw 714 3 Univ Univ NNP cord-020235-stcrozdw 714 4 . . . cord-020235-stcrozdw 715 1 , , , cord-020235-stcrozdw 715 2 D-6900 D-6900 VBD cord-020235-stcrozdw 715 3 Heidelberg Heidelberg NNP cord-020235-stcrozdw 715 4 ; ; : cord-020235-stcrozdw 715 5 t t NNP cord-020235-stcrozdw 715 6 Robert Robert NNP cord-020235-stcrozdw 715 7 - - HYPH cord-020235-stcrozdw 715 8 Koch Koch NNP cord-020235-stcrozdw 715 9 - - HYPH cord-020235-stcrozdw 715 10 Institut Institut NNP cord-020235-stcrozdw 715 11 , , , cord-020235-stcrozdw 715 12 D-1000 d-1000 CD cord-020235-stcrozdw 715 13 Berlin Berlin NNP cord-020235-stcrozdw 715 14 65 65 CD cord-020235-stcrozdw 715 15 ; ; : cord-020235-stcrozdw 715 16 2 2 CD cord-020235-stcrozdw 715 17 Inst Inst NNP cord-020235-stcrozdw 715 18 . . . cord-020235-stcrozdw 716 1 f. f. NNP cord-020235-stcrozdw 716 2 Virusforschung Virusforschung NNP cord-020235-stcrozdw 716 3 , , , cord-020235-stcrozdw 716 4 DKFZ DKFZ NNP cord-020235-stcrozdw 716 5 , , , cord-020235-stcrozdw 716 6 D-6900 D-6900 VBD cord-020235-stcrozdw 716 7 Heidelberg Heidelberg NNP cord-020235-stcrozdw 716 8 KURZ KURZ NNP cord-020235-stcrozdw 716 9 , , , cord-020235-stcrozdw 716 10 W. W. NNP cord-020235-stcrozdw 716 11 , , , cord-020235-stcrozdw 716 12 GELDERBLOM GELDERBLOM NNP cord-020235-stcrozdw 716 13 , , , cord-020235-stcrozdw 716 14 H.t H.t NNP cord-020235-stcrozdw 716 15 , , , cord-020235-stcrozdw 716 16 FLOGEL FLOGEL NNP cord-020235-stcrozdw 716 17 , , , cord-020235-stcrozdw 716 18 R. R. NNP cord-020235-stcrozdw 716 19 M.2 M.2 NNP cord-020235-stcrozdw 716 20 , , , cord-020235-stcrozdw 716 21 and and CC cord-020235-stcrozdw 716 22 DARAI DARAI NNP cord-020235-stcrozdw 716 23 , , , cord-020235-stcrozdw 717 1 G. G. NNP cord-020235-stcrozdw 717 2 A A NNP cord-020235-stcrozdw 717 3 paramyxovirus paramyxovirus NN cord-020235-stcrozdw 717 4 was be VBD cord-020235-stcrozdw 717 5 isolated isolate VBN cord-020235-stcrozdw 717 6 from from IN cord-020235-stcrozdw 717 7 a a DT cord-020235-stcrozdw 717 8 kidney kidney NN cord-020235-stcrozdw 717 9 biopsy biopsy NN cord-020235-stcrozdw 717 10 of of IN cord-020235-stcrozdw 717 11 a a DT cord-020235-stcrozdw 717 12 Tupaia Tupaia NNPS cord-020235-stcrozdw 717 13 ( ( -LRB- cord-020235-stcrozdw 717 14 three three CD cord-020235-stcrozdw 717 15 shrew shrew NN cord-020235-stcrozdw 717 16 ) ) -RRB- cord-020235-stcrozdw 717 17 and and CC cord-020235-stcrozdw 717 18 termed term VBN cord-020235-stcrozdw 717 19 ( ( -LRB- cord-020235-stcrozdw 717 20 TPV TPV NNP cord-020235-stcrozdw 717 21 ) ) -RRB- cord-020235-stcrozdw 717 22 . . . cord-020235-stcrozdw 718 1 The the DT cord-020235-stcrozdw 718 2 detailed detailed JJ cord-020235-stcrozdw 718 3 host host NN cord-020235-stcrozdw 718 4 range range NN cord-020235-stcrozdw 718 5 study study NN cord-020235-stcrozdw 718 6 revealed reveal VBD cord-020235-stcrozdw 718 7 that that IN cord-020235-stcrozdw 718 8 only only RB cord-020235-stcrozdw 718 9 Tupaia Tupaia NNP cord-020235-stcrozdw 718 10 embryonic embryonic JJ cord-020235-stcrozdw 718 11 fibroblasts fibroblast NNS cord-020235-stcrozdw 718 12 and and CC cord-020235-stcrozdw 718 13 Tupaia Tupaia NNP cord-020235-stcrozdw 718 14 kidney kidney NN cord-020235-stcrozdw 718 15 cells cell NNS cord-020235-stcrozdw 718 16 are be VBP cord-020235-stcrozdw 718 17 the the DT cord-020235-stcrozdw 718 18 cells cell NNS cord-020235-stcrozdw 718 19 of of IN cord-020235-stcrozdw 718 20 choice choice NN cord-020235-stcrozdw 718 21 for for IN cord-020235-stcrozdw 718 22 the the DT cord-020235-stcrozdw 718 23 efficient efficient JJ cord-020235-stcrozdw 718 24 propagation propagation NN cord-020235-stcrozdw 718 25 of of IN cord-020235-stcrozdw 718 26 TPV TPV NNP cord-020235-stcrozdw 718 27 . . . cord-020235-stcrozdw 719 1 TPV TPV NNP cord-020235-stcrozdw 719 2 can can MD cord-020235-stcrozdw 719 3 be be VB cord-020235-stcrozdw 719 4 plaque plaque NN cord-020235-stcrozdw 719 5 - - HYPH cord-020235-stcrozdw 719 6 assayed assay VBN cord-020235-stcrozdw 719 7 on on IN cord-020235-stcrozdw 719 8 Tupaia tupaia JJ cord-020235-stcrozdw 719 9 embryonic embryonic JJ cord-020235-stcrozdw 719 10 fibroblasts fibroblast NNS cord-020235-stcrozdw 719 11 and and CC cord-020235-stcrozdw 719 12 this this DT cord-020235-stcrozdw 719 13 cell cell NN cord-020235-stcrozdw 719 14 line line NN cord-020235-stcrozdw 719 15 was be VBD cord-020235-stcrozdw 719 16 used use VBN cord-020235-stcrozdw 719 17 for for IN cord-020235-stcrozdw 719 18 the the DT cord-020235-stcrozdw 719 19 continued continued JJ cord-020235-stcrozdw 719 20 propagation propagation NN cord-020235-stcrozdw 719 21 of of IN cord-020235-stcrozdw 719 22 TPV TPV NNP cord-020235-stcrozdw 719 23 . . . cord-020235-stcrozdw 720 1 Electron electron NN cord-020235-stcrozdw 720 2 microscopy microscopy NN cord-020235-stcrozdw 720 3 of of IN cord-020235-stcrozdw 720 4 purified purify VBN cord-020235-stcrozdw 720 5 TPV TPV NNP cord-020235-stcrozdw 720 6 revealed reveal VBD cord-020235-stcrozdw 720 7 the the DT cord-020235-stcrozdw 720 8 presence presence NN cord-020235-stcrozdw 720 9 of of IN cord-020235-stcrozdw 720 10 typical typical JJ cord-020235-stcrozdw 720 11 paramyxovirus paramyxovirus JJ cord-020235-stcrozdw 720 12 particles particle NNS cord-020235-stcrozdw 720 13 . . . cord-020235-stcrozdw 721 1 -The -The : cord-020235-stcrozdw 721 2 hemagglutination hemagglutination NN cord-020235-stcrozdw 721 3 test test NN cord-020235-stcrozdw 721 4 was be VBD cord-020235-stcrozdw 721 5 performed perform VBN cord-020235-stcrozdw 721 6 with with IN cord-020235-stcrozdw 721 7 erythrocytes erythrocyte NNS cord-020235-stcrozdw 721 8 with with IN cord-020235-stcrozdw 721 9 a a DT cord-020235-stcrozdw 721 10 variety variety NN cord-020235-stcrozdw 721 11 of of IN cord-020235-stcrozdw 721 12 different different JJ cord-020235-stcrozdw 721 13 species specie NNS cord-020235-stcrozdw 721 14 . . . cord-020235-stcrozdw 722 1 It -PRON- PRP cord-020235-stcrozdw 722 2 was be VBD cord-020235-stcrozdw 722 3 found find VBN cord-020235-stcrozdw 722 4 that that IN cord-020235-stcrozdw 722 5 guinea guinea NN cord-020235-stcrozdw 722 6 pig pig NN cord-020235-stcrozdw 722 7 erythrocytes erythrocyte NNS cord-020235-stcrozdw 722 8 were be VBD cord-020235-stcrozdw 722 9 agglutinated agglutinate VBN cord-020235-stcrozdw 722 10 with with IN cord-020235-stcrozdw 722 11 TPV TPV NNP cord-020235-stcrozdw 722 12 . . . cord-020235-stcrozdw 723 1 The the DT cord-020235-stcrozdw 723 2 buoyant buoyant JJ cord-020235-stcrozdw 723 3 density density NN cord-020235-stcrozdw 723 4 of of IN cord-020235-stcrozdw 723 5 purified purify VBN cord-020235-stcrozdw 723 6 virions virion NNS cord-020235-stcrozdw 723 7 was be VBD cord-020235-stcrozdw 723 8 determined determine VBN cord-020235-stcrozdw 723 9 in in IN cord-020235-stcrozdw 723 10 sucrose sucrose NN cord-020235-stcrozdw 723 11 gradient gradient NN cord-020235-stcrozdw 723 12 and and CC cord-020235-stcrozdw 723 13 found find VBD cord-020235-stcrozdw 723 14 to to TO cord-020235-stcrozdw 723 15 be be VB cord-020235-stcrozdw 723 16 1.19 1.19 CD cord-020235-stcrozdw 723 17 g g NN cord-020235-stcrozdw 723 18 X x NN cord-020235-stcrozdw 723 19 ml ml NN cord-020235-stcrozdw 723 20 " " '' cord-020235-stcrozdw 723 21 , , , cord-020235-stcrozdw 723 22 -The -The : cord-020235-stcrozdw 723 23 biological biological JJ cord-020235-stcrozdw 723 24 chara chara NN cord-020235-stcrozdw 723 25 cterization cterization NN cord-020235-stcrozdw 723 26 of of IN cord-020235-stcrozdw 723 27 TPV TPV NNP cord-020235-stcrozdw 723 28 which which WDT cord-020235-stcrozdw 723 29 was be VBD cord-020235-stcrozdw 723 30 perfo perfo NNP cord-020235-stcrozdw 723 31 rmed rme VBN cord-020235-stcrozdw 723 32 by by IN cord-020235-stcrozdw 723 33 host host NN cord-020235-stcrozdw 723 34 range range NN cord-020235-stcrozdw 723 35 study study NN cord-020235-stcrozdw 723 36 in in IN cord-020235-stcrozdw 723 37 vivo vivo NNP cord-020235-stcrozdw 723 38 revealed reveal VBD cord-020235-stcrozdw 723 39 that that IN cord-020235-stcrozdw 723 40 TPV TPV NNP cord-020235-stcrozdw 723 41 is be VBZ cord-020235-stcrozdw 723 42 highly highly RB cord-020235-stcrozdw 723 43 pathogenic pathogenic JJ cord-020235-stcrozdw 723 44 for for IN cord-020235-stcrozdw 723 45 new new JJ cord-020235-stcrozdw 723 46 born bear VBN cord-020235-stcrozdw 723 47 mice mouse NNS cord-020235-stcrozdw 723 48 and and CC cord-020235-stcrozdw 723 49 hamsters hamster NNS cord-020235-stcrozdw 723 50 . . . cord-020235-stcrozdw 724 1 -The -The : cord-020235-stcrozdw 724 2 characterization characterization NN cord-020235-stcrozdw 724 3 of of IN cord-020235-stcrozdw 724 4 viral viral JJ cord-020235-stcrozdw 724 5 RNA RNA NNP cord-020235-stcrozdw 724 6 and and CC cord-020235-stcrozdw 724 7 proteins protein NNS cord-020235-stcrozdw 724 8 of of IN cord-020235-stcrozdw 724 9 th th DT cord-020235-stcrozdw 724 10 is be VBZ cord-020235-stcrozdw 724 11 new new JJ cord-020235-stcrozdw 724 12 member member NN cord-020235-stcrozdw 724 13 of of IN cord-020235-stcrozdw 724 14 paramyxo paramyxo NNP cord-020235-stcrozdw 724 15 viridae viridae NNP cord-020235-stcrozdw 724 16 is be VBZ cord-020235-stcrozdw 724 17 now now RB cord-020235-stcrozdw 724 18 in in IN cord-020235-stcrozdw 724 19 progress progress NN cord-020235-stcrozdw 724 20 . . . cord-020235-stcrozdw 725 1 Coronaviruses coronaviruse NNS cord-020235-stcrozdw 725 2 contain contain VBP cord-020235-stcrozdw 725 3 two two CD cord-020235-stcrozdw 725 4 glycoprotein glycoprotein NN cord-020235-stcrozdw 725 5 species species NN cord-020235-stcrozdw 725 6 £ £ $ cord-020235-stcrozdw 725 7 2 2 CD cord-020235-stcrozdw 725 8 ( ( -LRB- cord-020235-stcrozdw 725 9 180 180 CD cord-020235-stcrozdw 725 10 K K NNP cord-020235-stcrozdw 725 11 ) ) -RRB- cord-020235-stcrozdw 725 12 and and CC cord-020235-stcrozdw 725 13 £ £ $ cord-020235-stcrozdw 725 14 1 1 CD cord-020235-stcrozdw 725 15 ( ( -LRB- cord-020235-stcrozdw 725 16 23 23 CD cord-020235-stcrozdw 725 17 K K NNP cord-020235-stcrozdw 725 18 ) ) -RRB- cord-020235-stcrozdw 725 19 which which WDT cord-020235-stcrozdw 725 20 are be VBP cord-020235-stcrozdw 725 21 both both DT cord-020235-stcrozdw 725 22 synthesized synthesize VBN cord-020235-stcrozdw 725 23 in in IN cord-020235-stcrozdw 725 24 the the DT cord-020235-stcrozdw 725 25 R£R r£r NN cord-020235-stcrozdw 725 26 of of IN cord-020235-stcrozdw 725 27 the the DT cord-020235-stcrozdw 725 28 infected infected JJ cord-020235-stcrozdw 725 29 host host NN cord-020235-stcrozdw 725 30 cell cell NN cord-020235-stcrozdw 725 31 . . . cord-020235-stcrozdw 726 1 Glycosylation glycosylation NN cord-020235-stcrozdw 726 2 of of IN cord-020235-stcrozdw 726 3 £ £ $ cord-020235-stcrozdw 726 4 2 2 CD cord-020235-stcrozdw 726 5 is be VBZ cord-020235-stcrozdw 726 6 initiated initiate VBN cord-020235-stcrozdw 726 7 at at IN cord-020235-stcrozdw 726 8 the the DT cord-020235-stcrozdw 726 9 cotranslational cotranslational JJ cord-020235-stcrozdw 726 10 level level NN cord-020235-stcrozdw 726 11 and and CC cord-020235-stcrozdw 726 12 it -PRON- PRP cord-020235-stcrozdw 726 13 can can MD cord-020235-stcrozdw 726 14 be be VB cord-020235-stcrozdw 726 15 inhibited inhibit VBN cord-020235-stcrozdw 726 16 by by IN cord-020235-stcrozdw 726 17 2-deoxyglucose 2-deoxyglucose CD cord-020235-stcrozdw 726 18 and and CC cord-020235-stcrozdw 726 19 tunicamycin tunicamycin NNS cord-020235-stcrozdw 726 20 indicating indicate VBG cord-020235-stcrozdw 726 21 the the DT cord-020235-stcrozdw 726 22 presence presence NN cord-020235-stcrozdw 726 23 of of IN cord-020235-stcrozdw 726 24 N n CD cord-020235-stcrozdw 726 25 - - HYPH cord-020235-stcrozdw 726 26 glycosidic glycosidic NNP cord-020235-stcrozdw 726 27 carbohydra carbohydra NNS cord-020235-stcrozdw 726 28 te te NNP cord-020235-stcrozdw 726 29 protein protein NN cord-020235-stcrozdw 726 30 linkages linkage NNS cord-020235-stcrozdw 726 31 . . . cord-020235-stcrozdw 727 1 Particles particle NNS cord-020235-stcrozdw 727 2 formed form VBN cord-020235-stcrozdw 727 3 in in IN cord-020235-stcrozdw 727 4 the the DT cord-020235-stcrozdw 727 5 presen presen NNP cord-020235-stcrozdw 727 6 ce ce NNP cord-020235-stcrozdw 727 7 of of IN cord-020235-stcrozdw 727 8 these these DT cord-020235-stcrozdw 727 9 inh inh NNP cord-020235-stcrozdw 727 10 ibit ibit NNP cord-020235-stcrozdw 727 11 ors or NNS cord-020235-stcrozdw 727 12 are be VBP cord-020235-stcrozdw 727 13 non non AFX cord-020235-stcrozdw 727 14 infectious infectious JJ cord-020235-stcrozdw 727 15 and and CC cord-020235-stcrozdw 727 16 lack lack NN cord-020235-stcrozdw 727 17 detect detect VB cord-020235-stcrozdw 727 18 able able JJ cord-020235-stcrozdw 727 19 amounts amount NNS cord-020235-stcrozdw 727 20 of of IN cord-020235-stcrozdw 727 21 £ £ $ cord-020235-stcrozdw 727 22 2 2 CD cord-020235-stcrozdw 727 23 . . . cord-020235-stcrozdw 728 1 -Cell -Cell NFP cord-020235-stcrozdw 729 1 fractionation fractionation NN cord-020235-stcrozdw 729 2 experiments experiment NNS cord-020235-stcrozdw 729 3 show show VBP cord-020235-stcrozdw 729 4 that that IN cord-020235-stcrozdw 729 5 glycosylation glycosylation NN cord-020235-stcrozdw 729 6 of of IN cord-020235-stcrozdw 729 7 glycoprotein glycoprotein NN cord-020235-stcrozdw 729 8 £ £ $ cord-020235-stcrozdw 729 9 1 1 CD cord-020235-stcrozdw 729 10 occur occur VBP cord-020235-stcrozdw 729 11 s s PRP cord-020235-stcrozdw 729 12 posttranslationally posttranslationally RB cord-020235-stcrozdw 729 13 in in IN cord-020235-stcrozdw 729 14 smooth smooth JJ cord-020235-stcrozdw 729 15 memb memb NNP cord-020235-stcrozdw 729 16 ranes rane NNS cord-020235-stcrozdw 729 17 . . . cord-020235-stcrozdw 730 1 The the DT cord-020235-stcrozdw 730 2 carb carb NN cord-020235-stcrozdw 730 3 ohydrate ohydrate NN cord-020235-stcrozdw 730 4 protein protein NN cord-020235-stcrozdw 730 5 linkages linkage NNS cord-020235-stcrozdw 730 6 in in IN cord-020235-stcrozdw 730 7 £ £ $ cord-020235-stcrozdw 730 8 1 1 CD cord-020235-stcrozdw 730 9 are be VBP cord-020235-stcrozdw 730 10 susceptible susceptible JJ cord-020235-stcrozdw 730 11 to to IN cord-020235-stcrozdw 730 12 mild mild JJ cord-020235-stcrozdw 730 13 alkaline alkaline JJ cord-020235-stcrozdw 730 14 reductive reductive JJ cord-020235-stcrozdw 730 15 conditions condition NNS cord-020235-stcrozdw 730 16 and and CC cord-020235-stcrozdw 730 17 N n CD cord-020235-stcrozdw 730 18 - - HYPH cord-020235-stcrozdw 730 19 acetylgalactosamine acetylgalactosamine NNP cord-020235-stcrozdw 730 20 was be VBD cord-020235-stcrozdw 730 21 determined determine VBN cord-020235-stcrozdw 730 22 to to TO cord-020235-stcrozdw 730 23 be be VB cord-020235-stcrozdw 730 24 the the DT cord-020235-stcrozdw 730 25 reduc reduc NN cord-020235-stcrozdw 730 26 ing e VBG cord-020235-stcrozdw 730 27 sugar sugar NN cord-020235-stcrozdw 730 28 of of IN cord-020235-stcrozdw 730 29 the the DT cord-020235-stcrozdw 730 30 released release VBN cord-020235-stcrozdw 730 31 oligo oligo NN cord-020235-stcrozdw 730 32 saccharides saccharide NNS cord-020235-stcrozdw 730 33 . . . cord-020235-stcrozdw 731 1 This this DT cord-020235-stcrozdw 731 2 together together RB cord-020235-stcrozdw 731 3 with with IN cord-020235-stcrozdw 731 4 the the DT cord-020235-stcrozdw 731 5 finding finding NN cord-020235-stcrozdw 731 6 that that DT cord-020235-stcrozdw 731 7 glycosylation glycosylation NN cord-020235-stcrozdw 731 8 of of IN cord-020235-stcrozdw 731 9 £ £ $ cord-020235-stcrozdw 731 10 1 1 CD cord-020235-stcrozdw 731 11 is be VBZ cord-020235-stcrozdw 731 12 not not RB cord-020235-stcrozdw 731 13 sensitive sensitive JJ cord-020235-stcrozdw 731 14 to to IN cord-020235-stcrozdw 731 15 inhibito inhibito FW cord-020235-stcrozdw 731 16 rs rs NNP cord-020235-stcrozdw 731 17 of of IN cord-020235-stcrozdw 731 18 N n NN cord-020235-stcrozdw 731 19 - - HYPH cord-020235-stcrozdw 731 20 glycosylation glycosylation NN cord-020235-stcrozdw 731 21 suggests suggest VBZ cord-020235-stcrozdw 731 22 that that IN cord-020235-stcrozdw 731 23 glycoprotein glycoprotein NN cord-020235-stcrozdw 731 24 in in IN cord-020235-stcrozdw 731 25 £ £ $ cord-020235-stcrozdw 731 26 1 1 CD cord-020235-stcrozdw 731 27 of of IN cord-020235-stcrozdw 731 28 coronaviruses coronaviruse NNS cord-020235-stcrozdw 731 29 is be VBZ cord-020235-stcrozdw 731 30 the the DT cord-020235-stcrozdw 731 31 first first JJ cord-020235-stcrozdw 731 32 structural structural JJ cord-020235-stcrozdw 731 33 virus virus NN cord-020235-stcrozdw 731 34 glycoprotein glycoprotein NN cord-020235-stcrozdw 731 35 containing contain VBG cord-020235-stcrozdw 731 36 O o UH cord-020235-stcrozdw 731 37 - - HYPH cord-020235-stcrozdw 731 38 glycosidic glycosidic JJ cord-020235-stcrozdw 731 39 side side NN cord-020235-stcrozdw 731 40 chains chain NNS cord-020235-stcrozdw 731 41 exclusively exclusively RB cord-020235-stcrozdw 731 42 . . . cord-020235-stcrozdw 732 1 Insr Insr NNP cord-020235-stcrozdw 732 2 , , , cord-020235-stcrozdw 732 3 £ £ NN cord-020235-stcrozdw 732 4 . . . cord-020235-stcrozdw 733 1 Virologie Virologie NNP cord-020235-stcrozdw 733 2 , , , cord-020235-stcrozdw 733 3 jusrus jusrus NNP cord-020235-stcrozdw 733 4 - - HYPH cord-020235-stcrozdw 733 5 Liebig Liebig NNP cord-020235-stcrozdw 733 6 - - HYPH cord-020235-stcrozdw 733 7 Univ Univ NNP cord-020235-stcrozdw 733 8 . . . cord-020235-stcrozdw 734 1 , , , cord-020235-stcrozdw 734 2 D-6300 d-6300 CD cord-020235-stcrozdw 734 3 Giessen Giessen NNP cord-020235-stcrozdw 734 4 Target Target NNP cord-020235-stcrozdw 734 5 Cells cell NNS cord-020235-stcrozdw 734 6 of of IN cord-020235-stcrozdw 734 7 Infectious Infectious NNP cord-020235-stcrozdw 734 8 Bursal Bursal NNP cord-020235-stcrozdw 734 9 Disease Disease NNP cord-020235-stcrozdw 734 10 Virus Virus NNP cord-020235-stcrozdw 734 11 ( ( -LRB- cord-020235-stcrozdw 734 12 IBDV IBDV NNP cord-020235-stcrozdw 734 13 ) ) -RRB- cord-020235-stcrozdw 734 14 of of IN cord-020235-stcrozdw 734 15 Chickens Chickens NNP cord-020235-stcrozdw 734 16 MOLLER MOLLER NNP cord-020235-stcrozdw 734 17 , , , cord-020235-stcrozdw 734 18 H. H. NNP cord-020235-stcrozdw 734 19 and and CC cord-020235-stcrozdw 734 20 BECHT BECHT NNP cord-020235-stcrozdw 734 21 , , , cord-020235-stcrozdw 734 22 H. H. NNP cord-020235-stcrozdw 734 23 Infectious infectious JJ cord-020235-stcrozdw 734 24 bursal bursal NN cord-020235-stcrozdw 734 25 disease disease NN cord-020235-stcrozdw 734 26 virus virus NN cord-020235-stcrozdw 734 27 ( ( -LRB- cord-020235-stcrozdw 734 28 IBDV IBDV NNP cord-020235-stcrozdw 734 29 ) ) -RRB- cord-020235-stcrozdw 734 30 , , , cord-020235-stcrozdw 734 31 the the DT cord-020235-stcrozdw 734 32 causative causative JJ cord-020235-stcrozdw 734 33 agent agent NN cord-020235-stcrozdw 734 34 of of IN cord-020235-stcrozdw 734 35 a a DT cord-020235-stcrozdw 734 36 highl highl NNP cord-020235-stcrozdw 734 37 y y NNP cord-020235-stcrozdw 734 38 contagious contagious JJ cord-020235-stcrozdw 734 39 disease disease NN cord-020235-stcrozdw 734 40 of of IN cord-020235-stcrozdw 734 41 young young JJ cord-020235-stcrozdw 734 42 chickens chicken NNS cord-020235-stcrozdw 734 43 result result VBP cord-020235-stcrozdw 734 44 ing e VBG cord-020235-stcrozdw 734 45 in in IN cord-020235-stcrozdw 734 46 severe severe JJ cord-020235-stcrozdw 734 47 necrotic necrotic JJ cord-020235-stcrozdw 734 48 lesions lesion NNS cord-020235-stcrozdw 734 49 in in IN cord-020235-stcrozdw 734 50 the the DT cord-020235-stcrozdw 734 51 bur bur NN cord-020235-stcrozdw 734 52 sa sa NN cord-020235-stcrozdw 734 53 of of IN cord-020235-stcrozdw 734 54 Fabricius Fabricius NNP cord-020235-stcrozdw 734 55 ( ( -LRB- cord-020235-stcrozdw 734 56 Gumboro Gumboro NNP cord-020235-stcrozdw 734 57 disease disease NN cord-020235-stcrozdw 734 58 ) ) -RRB- cord-020235-stcrozdw 734 59 , , , cord-020235-stcrozdw 734 60 is be VBZ cord-020235-stcrozdw 734 61 a a DT cord-020235-stcrozdw 734 62 non non JJ cord-020235-stcrozdw 734 63 - - JJ cord-020235-stcrozdw 734 64 enveloped enveloped JJ cord-020235-stcrozdw 734 65 icosahedral icosahedral JJ cord-020235-stcrozdw 734 66 particle particle NN cord-020235-stcrozdw 734 67 with with IN cord-020235-stcrozdw 734 68 a a DT cord-020235-stcrozdw 734 69 diameter diameter NN cord-020235-stcrozdw 734 70 of of IN cord-020235-stcrozdw 734 71 about about RB cord-020235-stcrozdw 734 72 60 60 CD cord-020235-stcrozdw 734 73 nm nm NN cord-020235-stcrozdw 734 74 . . . cord-020235-stcrozdw 735 1 Its -PRON- PRP$ cord-020235-stcrozdw 735 2 genome genome NN cord-020235-stcrozdw 735 3 con con NN cord-020235-stcrozdw 735 4 sists sist NNS cord-020235-stcrozdw 735 5 of of IN cord-020235-stcrozdw 735 6 2 2 CD cord-020235-stcrozdw 735 7 segments segment NNS cord-020235-stcrozdw 735 8 of of IN cord-020235-stcrozdw 735 9 double double RB cord-020235-stcrozdw 735 10 - - HYPH cord-020235-stcrozdw 735 11 stranded strand VBN cord-020235-stcrozdw 735 12 RNA RNA NNP cord-020235-stcrozdw 735 13 with with IN cord-020235-stcrozdw 735 14 mol mol NNP cord-020235-stcrozdw 735 15 ecular ecular NNP cord-020235-stcrozdw 735 16 weight weight NNP cord-020235-stcrozdw 735 17 s s NNP cord-020235-stcrozdw 735 18 of of IN cord-020235-stcrozdw 735 19 2.2 2.2 CD cord-020235-stcrozdw 735 20 X x SYM cord-020235-stcrozdw 735 21 10 10 CD cord-020235-stcrozdw 735 22 · · NFP cord-020235-stcrozdw 735 23 and and CC cord-020235-stcrozdw 735 24 2.5 2.5 CD cord-020235-stcrozdw 735 25 X X NNS cord-020235-stcrozdw 735 26 10 10 CD cord-020235-stcrozdw 735 27 · · NFP cord-020235-stcrozdw 735 28 daltons dalton NNS cord-020235-stcrozdw 735 29 . . . cord-020235-stcrozdw 736 1 Th th JJ cord-020235-stcrozdw 736 2 e e NN cord-020235-stcrozdw 736 3 virion virion NN cord-020235-stcrozdw 736 4 is be VBZ cord-020235-stcrozdw 736 5 composed compose VBN cord-020235-stcrozdw 736 6 of of IN cord-020235-stcrozdw 736 7 5 5 CD cord-020235-stcrozdw 736 8 structural structural JJ cord-020235-stcrozdw 736 9 pol pol NN cord-020235-stcrozdw 736 10 ypeptides ypeptides NNP cord-020235-stcrozdw 736 11 with with IN cord-020235-stcrozdw 736 12 mole mole NNP cord-020235-stcrozdw 736 13 cular cular NNP cord-020235-stcrozdw 736 14 weights weight NNS cord-020235-stcrozdw 736 15 of of IN cord-020235-stcrozdw 736 16 90 90 CD cord-020235-stcrozdw 736 17 kd kd NNS cord-020235-stcrozdw 736 18 , , , cord-020235-stcrozdw 736 19 48 48 CD cord-020235-stcrozdw 736 20 kd kd NNS cord-020235-stcrozdw 736 21 . . . cord-020235-stcrozdw 737 1 40 40 CD cord-020235-stcrozdw 737 2 kd kd NNP cord-020235-stcrozdw 737 3 , , , cord-020235-stcrozdw 737 4 32 32 CD cord-020235-stcrozdw 737 5 kd kd NNS cord-020235-stcrozdw 737 6 and and CC cord-020235-stcrozdw 737 7 28 28 CD cord-020235-stcrozdw 737 8 kd kd NNS cord-020235-stcrozdw 737 9 . . . cord-020235-stcrozdw 738 1 The the DT cord-020235-stcrozdw 738 2 40 40 CD cord-020235-stcrozdw 738 3 kd kd NNP cord-020235-stcrozdw 738 4 pol pol NNP cord-020235-stcrozdw 738 5 ypeptide ypeptide NNP cord-020235-stcrozdw 738 6 , , , cord-020235-stcrozdw 738 7 one one CD cord-020235-stcrozdw 738 8 of of IN cord-020235-stcrozdw 738 9 the the DT cord-020235-stcrozdw 738 10 two two CD cord-020235-stcrozdw 738 11 main main JJ cord-020235-stcrozdw 738 12 structural structural JJ cord-020235-stcrozdw 738 13 proteins protein NNS cord-020235-stcrozdw 738 14 , , , cord-020235-stcrozdw 738 15 is be VBZ cord-020235-stcrozdw 738 16 derived derive VBN cord-020235-stcrozdw 738 17 from from IN cord-020235-stcrozdw 738 18 the the DT cord-020235-stcrozdw 738 19 48 48 CD cord-020235-stcrozdw 738 20 kd kd NNP cord-020235-stcrozdw 738 21 pol pol NNP cord-020235-stcrozdw 738 22 ypeptide ypeptide NNP cord-020235-stcrozdw 738 23 , , , cord-020235-stcrozdw 738 24 perh perh NNP cord-020235-stcrozdw 738 25 aps aps NNP cord-020235-stcrozdw 738 26 by by IN cord-020235-stcrozdw 738 27 proteolytic proteolytic JJ cord-020235-stcrozdw 738 28 modification modification NN cord-020235-stcrozdw 738 29 ( ( -LRB- cord-020235-stcrozdw 738 30 1 1 CD cord-020235-stcrozdw 738 31 ) ) -RRB- cord-020235-stcrozdw 738 32 . . . cord-020235-stcrozdw 739 1 With with IN cord-020235-stcrozdw 739 2 immunofluorescence immunofluorescence NN cord-020235-stcrozdw 739 3 and and CC cord-020235-stcrozdw 739 4 " " `` cord-020235-stcrozdw 739 5 i i PRP cord-020235-stcrozdw 739 6 nfectious nfectious NNP cord-020235-stcrozdw 739 7 center center NNP cord-020235-stcrozdw 739 8 assays assay NNS cord-020235-stcrozdw 739 9 " " `` cord-020235-stcrozdw 739 10 we -PRON- PRP cord-020235-stcrozdw 739 11 were be VBD cord-020235-stcrozdw 739 12 able able JJ cord-020235-stcrozdw 739 13 to to TO cord-020235-stcrozdw 739 14 show show VB cord-020235-stcrozdw 739 15 th th XX cord-020235-stcrozdw 739 16 at at IN cord-020235-stcrozdw 739 17 1 1 CD cord-020235-stcrozdw 739 18 . . . cord-020235-stcrozdw 740 1 after after IN cord-020235-stcrozdw 740 2 infection infection NN cord-020235-stcrozdw 740 3 of of IN cord-020235-stcrozdw 740 4 isolated isolated JJ cord-020235-stcrozdw 740 5 lymphoid lymphoid JJ cord-020235-stcrozdw 740 6 cells cell NNS cord-020235-stcrozdw 740 7 in in IN cord-020235-stcrozdw 740 8 vitro vitro FW cord-020235-stcrozdw 740 9 only only RB cord-020235-stcrozdw 740 10 20 20 CD cord-020235-stcrozdw 740 11 Ofo Ofo NNP cord-020235-stcrozdw 740 12 of of IN cord-020235-stcrozdw 740 13 bur bur NNP cord-020235-stcrozdw 740 14 sa sa NNP cord-020235-stcrozdw 740 15 cells cell NNS cord-020235-stcrozdw 740 16 , , , cord-020235-stcrozdw 740 17 2 2 CD cord-020235-stcrozdw 740 18 % % NN cord-020235-stcrozdw 740 19 of of IN cord-020235-stcrozdw 740 20 thymus thymus NN cord-020235-stcrozdw 740 21 cells cell NNS cord-020235-stcrozdw 740 22 and and CC cord-020235-stcrozdw 740 23 5 5 CD cord-020235-stcrozdw 740 24 Ofo Ofo NNP cord-020235-stcrozdw 740 25 of of IN cord-020235-stcrozdw 740 26 spleen spleen NN cord-020235-stcrozdw 740 27 cells cell NNS cord-020235-stcrozdw 740 28 produce produce VBP cord-020235-stcrozdw 740 29 infective infective JJ cord-020235-stcrozdw 740 30 virus virus NN cord-020235-stcrozdw 740 31 ( ( -LRB- cord-020235-stcrozdw 740 32 i i PRP cord-020235-stcrozdw 740 33 , , , cord-020235-stcrozdw 740 34 e. e. NNP cord-020235-stcrozdw 740 35 plaques plaque NNS cord-020235-stcrozdw 740 36 in in IN cord-020235-stcrozdw 740 37 infectious infectious JJ cord-020235-stcrozdw 740 38 center center NN cord-020235-stcrozdw 740 39 assays assay NNS cord-020235-stcrozdw 740 40 ) ) -RRB- cord-020235-stcrozdw 741 1 alth alth NNP cord-020235-stcrozdw 741 2 ough ough NNP cord-020235-stcrozdw 742 1 the the DT cord-020235-stcrozdw 742 2 donor donor NN cord-020235-stcrozdw 742 3 chickens chicken NNS cord-020235-stcrozdw 742 4 were be VBD cord-020235-stcrozdw 742 5 in in IN cord-020235-stcrozdw 742 6 the the DT cord-020235-stcrozdw 742 7 most most RBS cord-020235-stcrozdw 742 8 susceptible susceptible JJ cord-020235-stcrozdw 742 9 age age NN cord-020235-stcrozdw 742 10 of of IN cord-020235-stcrozdw 742 11 4 4 CD cord-020235-stcrozdw 742 12 to to TO cord-020235-stcrozdw 742 13 5 5 CD cord-020235-stcrozdw 742 14 weeks week NNS cord-020235-stcrozdw 742 15 . . . cord-020235-stcrozdw 743 1 2 2 LS cord-020235-stcrozdw 743 2 . . . cord-020235-stcrozdw 744 1 the the DT cord-020235-stcrozdw 744 2 number number NN cord-020235-stcrozdw 744 3 of of IN cord-020235-stcrozdw 744 4 virus virus NN cord-020235-stcrozdw 744 5 producing produce VBG cord-020235-stcrozdw 744 6 cells cell NNS cord-020235-stcrozdw 744 7 is be VBZ cord-020235-stcrozdw 744 8 not not RB cord-020235-stcrozdw 744 9 cor cor NN cord-020235-stcrozdw 744 10 related relate VBN cord-020235-stcrozdw 744 11 with with IN cord-020235-stcrozdw 744 12 the the DT cord-020235-stcrozdw 744 13 appe appe NNP cord-020235-stcrozdw 744 14 arance arance NN cord-020235-stcrozdw 744 15 of of IN cord-020235-stcrozdw 744 16 slgM slgm VB cord-020235-stcrozdw 744 17 or or CC cord-020235-stcrozdw 744 18 sIgG. sigg. CD cord-020235-stcrozdw 744 19 3 3 CD cord-020235-stcrozdw 744 20 . . . cord-020235-stcrozdw 745 1 virus virus NN cord-020235-stcrozdw 745 2 yields yield NNS cord-020235-stcrozdw 745 3 seem seem VBP cord-020235-stcrozdw 745 4 to to TO cord-020235-stcrozdw 745 5 be be VB cord-020235-stcrozdw 745 6 influenced influence VBN cord-020235-stcrozdw 745 7 by by IN cord-020235-stcrozdw 745 8 the the DT cord-020235-stcrozdw 745 9 cell cell NN cord-020235-stcrozdw 745 10 cycle cycle NN cord-020235-stcrozdw 745 11 : : : cord-020235-stcrozdw 745 12 the the DT cord-020235-stcrozdw 745 13 number number NN cord-020235-stcrozdw 745 14 of of IN cord-020235-stcrozdw 745 15 chick chick NNP cord-020235-stcrozdw 745 16 emb emb NNP cord-020235-stcrozdw 745 17 ryo ryo NNP cord-020235-stcrozdw 745 18 fibro fibro NNP cord-020235-stcrozdw 745 19 blasts blast VBZ cord-020235-stcrozdw 745 20 producing produce VBG cord-020235-stcrozdw 745 21 plaques plaque NNS cord-020235-stcrozdw 745 22 in in IN cord-020235-stcrozdw 745 23 " " `` cord-020235-stcrozdw 745 24 infectious infectious JJ cord-020235-stcrozdw 745 25 center center NN cord-020235-stcrozdw 745 26 assays assay NNS cord-020235-stcrozdw 745 27 " " '' cord-020235-stcrozdw 745 28 is be VBZ cord-020235-stcrozdw 745 29 increased increase VBN cord-020235-stcrozdw 745 30 after after IN cord-020235-stcrozdw 745 31 synchro synchro NNP cord-020235-stcrozdw 745 32 nisa nisa NNP cord-020235-stcrozdw 745 33 tion tion NNP cord-020235-stcrozdw 745 34 of of IN cord-020235-stcrozdw 745 35 the the DT cord-020235-stcrozdw 745 36 cells cell NNS cord-020235-stcrozdw 745 37 before before IN cord-020235-stcrozdw 745 38 infection infection NN cord-020235-stcrozdw 745 39 . . . cord-020235-stcrozdw 746 1 4 4 LS cord-020235-stcrozdw 746 2 . . . cord-020235-stcrozdw 746 3 cells cell NNS cord-020235-stcrozdw 746 4 that that WDT cord-020235-stcrozdw 746 5 produce produce VBP cord-020235-stcrozdw 746 6 infective infective JJ cord-020235-stcrozdw 746 7 virus virus NN cord-020235-stcrozdw 746 8 show show VB cord-020235-stcrozdw 746 9 an an DT cord-020235-stcrozdw 746 10 increased increase VBN cord-020235-stcrozdw 746 11 uptake uptake NN cord-020235-stcrozdw 746 12 of of IN cord-020235-stcrozdw 746 13 3H 3h CD cord-020235-stcrozdw 746 14 - - HYPH cord-020235-stcrozdw 746 15 thymidine thymidine NN cord-020235-stcrozdw 746 16 . . . cord-020235-stcrozdw 747 1 5 5 LS cord-020235-stcrozdw 747 2 . . . cord-020235-stcrozdw 748 1 isolated isolate VBN cord-020235-stcrozdw 748 2 lymphoid lymphoid JJ cord-020235-stcrozdw 748 3 cells cell NNS cord-020235-stcrozdw 748 4 from from IN cord-020235-stcrozdw 748 5 thymus thymus NN cord-020235-stcrozdw 748 6 or or CC cord-020235-stcrozdw 748 7 spleen spleen NN cord-020235-stcrozdw 748 8 as as RB cord-020235-stcrozdw 748 9 well well RB cord-020235-stcrozdw 748 10 as as IN cord-020235-stcrozdw 748 11 blood blood NN cord-020235-stcrozdw 748 12 lymphocytes lymphocyte NNS cord-020235-stcrozdw 748 13 can can MD cord-020235-stcrozdw 748 14 be be VB cord-020235-stcrozdw 748 15 stimulated stimulate VBN cord-020235-stcrozdw 748 16 by by IN cord-020235-stcrozdw 748 17 mitogens mitogen NNS cord-020235-stcrozdw 748 18 to to TO cord-020235-stcrozdw 748 19 produce produce VB cord-020235-stcrozdw 748 20 higher high JJR cord-020235-stcrozdw 748 21 virus virus NN cord-020235-stcrozdw 748 22 yields yield NNS cord-020235-stcrozdw 748 23 . . . cord-020235-stcrozdw 749 1 infection infection NN cord-020235-stcrozdw 749 2 of of IN cord-020235-stcrozdw 749 3 Borna Borna NNP cord-020235-stcrozdw 749 4 virus virus NN cord-020235-stcrozdw 749 5 without without IN cord-020235-stcrozdw 749 6 any any DT cord-020235-stcrozdw 749 7 influence influence NN cord-020235-stcrozdw 749 8 of of IN cord-020235-stcrozdw 749 9 the the DT cord-020235-stcrozdw 749 10 immunoresponse immunoresponse NN cord-020235-stcrozdw 749 11 . . . cord-020235-stcrozdw 750 1 The the DT cord-020235-stcrozdw 750 2 antigens antigen NNS cord-020235-stcrozdw 750 3 first first RB cord-020235-stcrozdw 750 4 appeared appear VBD cord-020235-stcrozdw 750 5 in in IN cord-020235-stcrozdw 750 6 the the DT cord-020235-stcrozdw 750 7 nucleus nucleus NN cord-020235-stcrozdw 750 8 of of IN cord-020235-stcrozdw 750 9 neurons neuron NNS cord-020235-stcrozdw 750 10 and and CC cord-020235-stcrozdw 750 11 sometimes sometimes RB cord-020235-stcrozdw 750 12 fibroblasts fibroblast NNS cord-020235-stcrozdw 750 13 , , , cord-020235-stcrozdw 750 14 then then RB cord-020235-stcrozdw 750 15 filled fill VBD cord-020235-stcrozdw 750 16 the the DT cord-020235-stcrozdw 750 17 cytoplasm cytoplasm NN cord-020235-stcrozdw 750 18 , , , cord-020235-stcrozdw 750 19 most most RBS cord-020235-stcrozdw 750 20 brilliantly brilliantly RB cord-020235-stcrozdw 750 21 7 7 CD cord-020235-stcrozdw 750 22 days day NNS cord-020235-stcrozdw 750 23 post post NN cord-020235-stcrozdw 750 24 infection infection NN cord-020235-stcrozdw 750 25 . . . cord-020235-stcrozdw 751 1 Thereafter thereafter RB cord-020235-stcrozdw 751 2 they -PRON- PRP cord-020235-stcrozdw 751 3 disappeared disappear VBD cord-020235-stcrozdw 751 4 from from IN cord-020235-stcrozdw 751 5 the the DT cord-020235-stcrozdw 751 6 cytoplasm cytoplasm NN cord-020235-stcrozdw 751 7 , , , cord-020235-stcrozdw 751 8 but but CC cord-020235-stcrozdw 751 9 remained remain VBD cord-020235-stcrozdw 751 10 persistently persistently RB cord-020235-stcrozdw 751 11 only only RB cord-020235-stcrozdw 751 12 in in IN cord-020235-stcrozdw 751 13 the the DT cord-020235-stcrozdw 751 14 nucleus nucleus NN cord-020235-stcrozdw 751 15 in in IN cord-020235-stcrozdw 751 16 point point NN cord-020235-stcrozdw 751 17 shape shape NN cord-020235-stcrozdw 751 18 . . . cord-020235-stcrozdw 752 1 No no DT cord-020235-stcrozdw 752 2 morphological morphological JJ cord-020235-stcrozdw 752 3 changes change NNS cord-020235-stcrozdw 752 4 were be VBD cord-020235-stcrozdw 752 5 seen see VBN cord-020235-stcrozdw 752 6 in in IN cord-020235-stcrozdw 752 7 the the DT cord-020235-stcrozdw 752 8 infected infected JJ cord-020235-stcrozdw 752 9 cells cell NNS cord-020235-stcrozdw 752 10 during during IN cord-020235-stcrozdw 752 11 60 60 CD cord-020235-stcrozdw 752 12 days day NNS cord-020235-stcrozdw 752 13 post post NN cord-020235-stcrozdw 752 14 infection infection NN cord-020235-stcrozdw 752 15 . . . cord-020235-stcrozdw 753 1 We -PRON- PRP cord-020235-stcrozdw 753 2 can can MD cord-020235-stcrozdw 753 3 say say VB cord-020235-stcrozdw 753 4 that that IN cord-020235-stcrozdw 753 5 the the DT cord-020235-stcrozdw 753 6 virus virus NN cord-020235-stcrozdw 753 7 does do VBZ cord-020235-stcrozdw 753 8 not not RB cord-020235-stcrozdw 753 9 kill kill VB cord-020235-stcrozdw 753 10 the the DT cord-020235-stcrozdw 753 11 cell cell NN cord-020235-stcrozdw 753 12 . . . cord-020235-stcrozdw 754 1 For for IN cord-020235-stcrozdw 754 2 the the DT cord-020235-stcrozdw 754 3 destruction destruction NN cord-020235-stcrozdw 754 4 of of IN cord-020235-stcrozdw 754 5 nerve nerve NN cord-020235-stcrozdw 754 6 cells cell NNS cord-020235-stcrozdw 754 7 in in IN cord-020235-stcrozdw 754 8 in in IN cord-020235-stcrozdw 754 9 vivo vivo NN cord-020235-stcrozdw 754 10 conditions condition NNS cord-020235-stcrozdw 754 11 it -PRON- PRP cord-020235-stcrozdw 754 12 can can MD cord-020235-stcrozdw 754 13 be be VB cord-020235-stcrozdw 754 14 pointed point VBN cord-020235-stcrozdw 754 15 to to IN cord-020235-stcrozdw 754 16 the the DT cord-020235-stcrozdw 754 17 importance importance NN cord-020235-stcrozdw 754 18 of of IN cord-020235-stcrozdw 754 19 the the DT cord-020235-stcrozdw 754 20 immunological immunological JJ cord-020235-stcrozdw 754 21 events event NNS cord-020235-stcrozdw 754 22 , , , cord-020235-stcrozdw 754 23 which which WDT cord-020235-stcrozdw 754 24 might may MD cord-020235-stcrozdw 754 25 cause cause VB cord-020235-stcrozdw 754 26 the the DT cord-020235-stcrozdw 754 27 clinical clinical JJ cord-020235-stcrozdw 754 28 pictures picture NNS cord-020235-stcrozdw 754 29 . . . cord-020235-stcrozdw 755 1 Abr Abr NNP cord-020235-stcrozdw 755 2 , , , cord-020235-stcrozdw 755 3 Molekularbiologie Molekularbiologie NNP cord-020235-stcrozdw 755 4 , , , cord-020235-stcrozdw 755 5 Physiol.-Chem Physiol.-Chem NNP cord-020235-stcrozdw 755 6 . . . cord-020235-stcrozdw 756 1 lnst lnst NNP cord-020235-stcrozdw 756 2 . . NNP cord-020235-stcrozdw 756 3 , , , cord-020235-stcrozdw 756 4 Grindelallee Grindelallee NNP cord-020235-stcrozdw 756 5 117 117 CD cord-020235-stcrozdw 756 6 , , , cord-020235-stcrozdw 756 7 D-2000 d-2000 CD cord-020235-stcrozdw 756 8 Hamburg Hamburg NNP cord-020235-stcrozdw 756 9 13 13 CD cord-020235-stcrozdw 756 10 ; ; : cord-020235-stcrozdw 756 11 Heinrich Heinrich NNP cord-020235-stcrozdw 756 12 Pette Pette NNP cord-020235-stcrozdw 756 13 - - HYPH cord-020235-stcrozdw 756 14 Inst Inst NNP cord-020235-stcrozdw 756 15 . . . cord-020235-stcrozdw 757 1 , , , cord-020235-stcrozdw 757 2 Martinistr Martinistr NNP cord-020235-stcrozdw 757 3 . . . cord-020235-stcrozdw 758 1 52 52 CD cord-020235-stcrozdw 758 2 , , , cord-020235-stcrozdw 758 3 D-2000 d-2000 CD cord-020235-stcrozdw 759 1 Hamburg Hamburg NNP cord-020235-stcrozdw 759 2 20 20 CD cord-020235-stcrozdw 759 3 Large large JJ cord-020235-stcrozdw 759 4 Scale scale NN cord-020235-stcrozdw 759 5 Production production NN cord-020235-stcrozdw 759 6 of of IN cord-020235-stcrozdw 759 7 Biologically biologically RB cord-020235-stcrozdw 759 8 Active active JJ cord-020235-stcrozdw 759 9 VSV VSV NNP cord-020235-stcrozdw 759 10 in in IN cord-020235-stcrozdw 759 11 EAT EAT NNP cord-020235-stcrozdw 759 12 - - HYPH cord-020235-stcrozdw 759 13 Cells cell NNS cord-020235-stcrozdw 759 14 MACK MACK NNP cord-020235-stcrozdw 759 15 , , , cord-020235-stcrozdw 759 16 D. D. NNP cord-020235-stcrozdw 759 17 , , , cord-020235-stcrozdw 759 18 KRUPPA KRUPPA NNP cord-020235-stcrozdw 759 19 , , , cord-020235-stcrozdw 759 20 J. J. NNP cord-020235-stcrozdw 759 21 , , , cord-020235-stcrozdw 759 22 and and CC cord-020235-stcrozdw 759 23 BREINDL BREINDL NNP cord-020235-stcrozdw 759 24 , , , cord-020235-stcrozdw 760 1 M.I M.I NNP cord-020235-stcrozdw 760 2 Ehrlich Ehrlich NNP cord-020235-stcrozdw 760 3 ascites ascites NN cord-020235-stcrozdw 760 4 tumor tumor NN cord-020235-stcrozdw 760 5 cells cell NNS cord-020235-stcrozdw 760 6 maintained maintain VBN cord-020235-stcrozdw 760 7 in in IN cord-020235-stcrozdw 760 8 mice mouse NNS cord-020235-stcrozdw 760 9 were be VBD cord-020235-stcrozdw 760 10 used use VBN cord-020235-stcrozdw 760 11 to to TO cord-020235-stcrozdw 760 12 prepare prepare VB cord-020235-stcrozdw 760 13 milligram milligram JJ cord-020235-stcrozdw 760 14 quantities quantity NNS cord-020235-stcrozdw 760 15 of of IN cord-020235-stcrozdw 760 16 biologically biologically RB cord-020235-stcrozdw 760 17 active active JJ cord-020235-stcrozdw 760 18 VSV VSV NNP cord-020235-stcrozdw 760 19 . . . cord-020235-stcrozdw 761 1 At at IN cord-020235-stcrozdw 761 2 the the DT cord-020235-stcrozdw 761 3 6th 6th JJ cord-020235-stcrozdw 761 4 day day NN cord-020235-stcrozdw 761 5 after after IN cord-020235-stcrozdw 761 6 passage passage NN cord-020235-stcrozdw 761 7 when when WRB cord-020235-stcrozdw 761 8 the the DT cord-020235-stcrozdw 761 9 cell cell NN cord-020235-stcrozdw 761 10 number number NN cord-020235-stcrozdw 761 11 reached reach VBD cord-020235-stcrozdw 761 12 approx approx NN cord-020235-stcrozdw 761 13 . . . cord-020235-stcrozdw 761 14 7 7 CD cord-020235-stcrozdw 761 15 X x CD cord-020235-stcrozdw 761 16 10 10 CD cord-020235-stcrozdw 761 17 8 8 CD cord-020235-stcrozdw 761 18 cells cell NNS cord-020235-stcrozdw 761 19 / / SYM cord-020235-stcrozdw 761 20 mouse mouse NN cord-020235-stcrozdw 761 21 , , , cord-020235-stcrozdw 761 22 mice mouse NNS cord-020235-stcrozdw 761 23 were be VBD cord-020235-stcrozdw 761 24 infected infect VBN cord-020235-stcrozdw 761 25 by by IN cord-020235-stcrozdw 761 26 intraperitoneal intraperitoneal JJ cord-020235-stcrozdw 761 27 injection injection NN cord-020235-stcrozdw 761 28 of of IN cord-020235-stcrozdw 761 29 appropriate appropriate JJ cord-020235-stcrozdw 761 30 concentrations concentration NNS cord-020235-stcrozdw 761 31 of of IN cord-020235-stcrozdw 761 32 VSV VSV NNP cord-020235-stcrozdw 761 33 . . . cord-020235-stcrozdw 762 1 Ascites Ascites NNPS cord-020235-stcrozdw 762 2 fluid fluid NN cord-020235-stcrozdw 762 3 was be VBD cord-020235-stcrozdw 762 4 harvested harvest VBN cord-020235-stcrozdw 762 5 after after IN cord-020235-stcrozdw 762 6 20 20 CD cord-020235-stcrozdw 762 7 h. h. NNP cord-020235-stcrozdw 762 8 Virus Virus NNP cord-020235-stcrozdw 762 9 production production NN cord-020235-stcrozdw 762 10 was be VBD cord-020235-stcrozdw 762 11 exponential exponential JJ cord-020235-stcrozdw 762 12 for for IN cord-020235-stcrozdw 762 13 at at RB cord-020235-stcrozdw 762 14 least least RBS cord-020235-stcrozdw 762 15 16 16 CD cord-020235-stcrozdw 762 16 h h NN cord-020235-stcrozdw 762 17 and and CC cord-020235-stcrozdw 762 18 continued continue VBD cord-020235-stcrozdw 762 19 for for IN cord-020235-stcrozdw 762 20 at at RB cord-020235-stcrozdw 762 21 least least RBS cord-020235-stcrozdw 762 22 20 20 CD cord-020235-stcrozdw 762 23 h h NN cord-020235-stcrozdw 762 24 p.i p.i NNP cord-020235-stcrozdw 762 25 . . . cord-020235-stcrozdw 763 1 -Approximately -approximately RB cord-020235-stcrozdw 763 2 3 3 CD cord-020235-stcrozdw 763 3 - - SYM cord-020235-stcrozdw 763 4 4 4 CD cord-020235-stcrozdw 763 5 mg mg NN cord-020235-stcrozdw 763 6 of of IN cord-020235-stcrozdw 763 7 viral viral JJ cord-020235-stcrozdw 763 8 protein protein NN cord-020235-stcrozdw 763 9 / / SYM cord-020235-stcrozdw 763 10 mouse mouse NN cord-020235-stcrozdw 763 11 and and CC cord-020235-stcrozdw 763 12 2 2 CD cord-020235-stcrozdw 763 13 X x NN cord-020235-stcrozdw 763 14 1011 1011 CD cord-020235-stcrozdw 763 15 PFUlmouse pfulmouse NN cord-020235-stcrozdw 763 16 were be VBD cord-020235-stcrozdw 763 17 routinely routinely RB cord-020235-stcrozdw 763 18 obtained obtain VBN cord-020235-stcrozdw 763 19 . . . cord-020235-stcrozdw 764 1 The the DT cord-020235-stcrozdw 764 2 specific specific JJ cord-020235-stcrozdw 764 3 infectivity infectivity NN cord-020235-stcrozdw 764 4 of of IN cord-020235-stcrozdw 764 5 VSV VSV NNP cord-020235-stcrozdw 764 6 isolated isolate VBN cord-020235-stcrozdw 764 7 from from IN cord-020235-stcrozdw 764 8 EAT eat NN cord-020235-stcrozdw 764 9 - - HYPH cord-020235-stcrozdw 764 10 cells cell NNS cord-020235-stcrozdw 764 11 reached reach VBD cord-020235-stcrozdw 764 12 nearly nearly RB cord-020235-stcrozdw 764 13 1.5 1.5 CD cord-020235-stcrozdw 764 14 X X NNS cord-020235-stcrozdw 764 15 10 10 CD cord-020235-stcrozdw 764 16 8 8 CD cord-020235-stcrozdw 764 17 PFUI PFUI NNP cord-020235-stcrozdw 764 18 , , , cord-020235-stcrozdw 764 19 ug ug NNP cord-020235-stcrozdw 764 20 protein protein NN cord-020235-stcrozdw 764 21 . . . cord-020235-stcrozdw 765 1 The the DT cord-020235-stcrozdw 765 2 endogenous endogenous JJ cord-020235-stcrozdw 765 3 transcriptase transcriptase NN cord-020235-stcrozdw 765 4 activity activity NN cord-020235-stcrozdw 765 5 of of IN cord-020235-stcrozdw 765 6 VSV VSV NNP cord-020235-stcrozdw 765 7 produced produce VBD cord-020235-stcrozdw 765 8 in in IN cord-020235-stcrozdw 765 9 EAT EAT NNP cord-020235-stcrozdw 765 10 , , , cord-020235-stcrozdw 765 11 BHK BHK NNP cord-020235-stcrozdw 765 12 , , , cord-020235-stcrozdw 765 13 and and CC cord-020235-stcrozdw 765 14 HeLa HeLa NNP cord-020235-stcrozdw 765 15 cells cell NNS cord-020235-stcrozdw 765 16 showed show VBD cord-020235-stcrozdw 765 17 no no DT cord-020235-stcrozdw 765 18 significant significant JJ cord-020235-stcrozdw 765 19 differences difference NNS cord-020235-stcrozdw 765 20 . . . cord-020235-stcrozdw 766 1 Large large JJ cord-020235-stcrozdw 766 2 amounts amount NNS cord-020235-stcrozdw 766 3 of of IN cord-020235-stcrozdw 766 4 biologically biologically RB cord-020235-stcrozdw 766 5 active active JJ cord-020235-stcrozdw 766 6 VSV VSV NNP cord-020235-stcrozdw 766 7 may may MD cord-020235-stcrozdw 766 8 be be VB cord-020235-stcrozdw 766 9 produced produce VBN cord-020235-stcrozdw 766 10 rapidly rapidly RB cord-020235-stcrozdw 766 11 and and CC cord-020235-stcrozdw 766 12 much much RB cord-020235-stcrozdw 766 13 less less RBR cord-020235-stcrozdw 766 14 costly costly JJ cord-020235-stcrozdw 766 15 with with IN cord-020235-stcrozdw 766 16 the the DT cord-020235-stcrozdw 766 17 described describe VBN cord-020235-stcrozdw 766 18 procedure procedure NN cord-020235-stcrozdw 766 19 than than IN cord-020235-stcrozdw 766 20 using use VBG cord-020235-stcrozdw 766 21 tissue tissue NN cord-020235-stcrozdw 766 22 culture culture NN cord-020235-stcrozdw 766 23 cells cell NNS cord-020235-stcrozdw 766 24 . . . cord-020235-stcrozdw 767 1 It -PRON- PRP cord-020235-stcrozdw 767 2 should should MD cord-020235-stcrozdw 767 3 be be VB cord-020235-stcrozdw 767 4 possible possible JJ cord-020235-stcrozdw 767 5 to to TO cord-020235-stcrozdw 767 6 adapt adapt VB cord-020235-stcrozdw 767 7 the the DT cord-020235-stcrozdw 767 8 procedure procedure NN cord-020235-stcrozdw 767 9 for for IN cord-020235-stcrozdw 767 10 the the DT cord-020235-stcrozdw 767 11 production production NN cord-020235-stcrozdw 767 12 of of IN cord-020235-stcrozdw 767 13 other other JJ cord-020235-stcrozdw 767 14 viruses virus NNS cord-020235-stcrozdw 767 15 . . . cord-020235-stcrozdw 768 1 Lonza Lonza NNP cord-020235-stcrozdw 768 2 A.G. A.G. NNP cord-020235-stcrozdw 768 3 , , , cord-020235-stcrozdw 768 4 CH-4000 CH-4000 NNP cord-020235-stcrozdw 768 5 Basel Basel NNP cord-020235-stcrozdw 768 6 , , , cord-020235-stcrozdw 768 7 Schweiz Schweiz NNP cord-020235-stcrozdw 769 1 The the DT cord-020235-stcrozdw 769 2 Quantitative Quantitative NNP cord-020235-stcrozdw 769 3 Determination determination NN cord-020235-stcrozdw 769 4 of of IN cord-020235-stcrozdw 769 5 Bardac-22 bardac-22 NN cord-020235-stcrozdw 769 6 , , , cord-020235-stcrozdw 769 7 Formaldehyde Formaldehyde NNP cord-020235-stcrozdw 769 8 , , , cord-020235-stcrozdw 769 9 Glyoxal Glyoxal NNP cord-020235-stcrozdw 769 10 and and CC cord-020235-stcrozdw 769 11 Glutardialdehyde Glutardialdehyde NNP cord-020235-stcrozdw 769 12 in in IN cord-020235-stcrozdw 769 13 Disinfectants Disinfectants NNP cord-020235-stcrozdw 769 14 WEINREIS WEINREIS NNP cord-020235-stcrozdw 769 15 , , , cord-020235-stcrozdw 769 16 P. P. NNP cord-020235-stcrozdw 769 17 and and CC cord-020235-stcrozdw 769 18 GOLLER GOLLER NNP cord-020235-stcrozdw 769 19 , , , cord-020235-stcrozdw 770 1 S. S. NNP cord-020235-stcrozdw 770 2 Several several JJ cord-020235-stcrozdw 770 3 institutes institute NNS cord-020235-stcrozdw 770 4 of of IN cord-020235-stcrozdw 770 5 hygiene hygiene NN cord-020235-stcrozdw 770 6 have have VBP cord-020235-stcrozdw 770 7 been be VBN cord-020235-stcrozdw 770 8 provided provide VBN cord-020235-stcrozdw 770 9 with with IN cord-020235-stcrozdw 770 10 two two CD cord-020235-stcrozdw 770 11 disinfected disinfect VBN cord-020235-stcrozdw 770 12 formulations formulation NNS cord-020235-stcrozdw 770 13 , , , cord-020235-stcrozdw 770 14 A a NN cord-020235-stcrozdw 770 15 and and CC cord-020235-stcrozdw 770 16 B b NN cord-020235-stcrozdw 770 17 , , , cord-020235-stcrozdw 770 18 with with IN cord-020235-stcrozdw 770 19 the the DT cord-020235-stcrozdw 770 20 intention intention NN cord-020235-stcrozdw 770 21 to to TO cord-020235-stcrozdw 770 22 analyse analyse VB cord-020235-stcrozdw 770 23 these these DT cord-020235-stcrozdw 770 24 mixtures mixture NNS cord-020235-stcrozdw 770 25 , , , cord-020235-stcrozdw 770 26 containing contain VBG cord-020235-stcrozdw 770 27 different different JJ cord-020235-stcrozdw 770 28 amounts amount NNS cord-020235-stcrozdw 770 29 of of IN cord-020235-stcrozdw 770 30 quaternary quaternary JJ cord-020235-stcrozdw 770 31 ammonium ammonium NN cord-020235-stcrozdw 770 32 compounds compound NNS cord-020235-stcrozdw 770 33 , , , cord-020235-stcrozdw 770 34 formaldehyde formaldehyde NN cord-020235-stcrozdw 770 35 , , , cord-020235-stcrozdw 770 36 glyoxal glyoxal NNP cord-020235-stcrozdw 770 37 and and CC cord-020235-stcrozdw 770 38 glutardialdehyde glutardialdehyde NNP cord-020235-stcrozdw 770 39 , , , cord-020235-stcrozdw 770 40 -The -The : cord-020235-stcrozdw 770 41 quantitative quantitative JJ cord-020235-stcrozdw 770 42 analysis analysis NN cord-020235-stcrozdw 770 43 of of IN cord-020235-stcrozdw 770 44 the the DT cord-020235-stcrozdw 770 45 components component NNS cord-020235-stcrozdw 770 46 of of IN cord-020235-stcrozdw 770 47 the the DT cord-020235-stcrozdw 770 48 two two CD cord-020235-stcrozdw 770 49 mixtures mixture NNS cord-020235-stcrozdw 770 50 depends depend VBZ cord-020235-stcrozdw 770 51 on on IN cord-020235-stcrozdw 770 52 well well RB cord-020235-stcrozdw 770 53 known know VBN cord-020235-stcrozdw 770 54 volumetric volumetric NN cord-020235-stcrozdw 770 55 and and CC cord-020235-stcrozdw 770 56 spectrophotometric spectrophotometric JJ cord-020235-stcrozdw 770 57 methods method NNS cord-020235-stcrozdw 770 58 . . . cord-020235-stcrozdw 771 1 -The -The : cord-020235-stcrozdw 771 2 results result NNS cord-020235-stcrozdw 771 3 of of IN cord-020235-stcrozdw 771 4 this this DT cord-020235-stcrozdw 771 5 analysis analysis NN cord-020235-stcrozdw 771 6 have have VBP cord-020235-stcrozdw 771 7 shown show VBN cord-020235-stcrozdw 771 8 that that IN cord-020235-stcrozdw 771 9 it -PRON- PRP cord-020235-stcrozdw 771 10 is be VBZ cord-020235-stcrozdw 771 11 possible possible JJ cord-020235-stcrozdw 771 12 to to TO cord-020235-stcrozdw 771 13 use use VB cord-020235-stcrozdw 771 14 the the DT cord-020235-stcrozdw 771 15 described describe VBN cord-020235-stcrozdw 771 16 procedure procedure NN cord-020235-stcrozdw 771 17 for for IN cord-020235-stcrozdw 771 18 routine routine JJ cord-020235-stcrozdw 771 19 check check NN cord-020235-stcrozdw 771 20 ups up NNS cord-020235-stcrozdw 771 21 of of IN cord-020235-stcrozdw 771 22 disinfectants disinfectant NNS cord-020235-stcrozdw 771 23 without without IN cord-020235-stcrozdw 771 24 using use VBG cord-020235-stcrozdw 771 25 microbiological microbiological JJ cord-020235-stcrozdw 771 26 tests test NNS cord-020235-stcrozdw 771 27 . . . cord-020235-stcrozdw 772 1 Proc proc VB cord-020235-stcrozdw 772 2 . . . cord-020235-stcrozdw 773 1 nat nat NNP cord-020235-stcrozdw 773 2 . . . cord-020235-stcrozdw 774 1 Acad Acad NNP cord-020235-stcrozdw 774 2 . . . cord-020235-stcrozdw 775 1 Sci Sci NNP cord-020235-stcrozdw 775 2 Virolog Virolog NNP cord-020235-stcrozdw 775 3 y y NNP cord-020235-stcrozdw 775 4 ( ( -LRB- cord-020235-stcrozdw 775 5 1982 1982 CD cord-020235-stcrozdw 775 6 ) ) -RRB- cord-020235-stcrozdw 776 1 Previous previous JJ cord-020235-stcrozdw 776 2 studies study NNS cord-020235-stcrozdw 776 3 have have VBP cord-020235-stcrozdw 776 4 shown show VBN cord-020235-stcrozdw 776 5 , , , cord-020235-stcrozdw 776 6 that that IN cord-020235-stcrozdw 776 7 mouse mouse NN cord-020235-stcrozdw 776 8 - - HYPH cord-020235-stcrozdw 776 9 neurovirulent neurovirulent NN cord-020235-stcrozdw 776 10 recombinants recombinant NNS cord-020235-stcrozdw 776 11 can can MD cord-020235-stcrozdw 776 12 be be VB cord-020235-stcrozdw 776 13 obtained obtain VBN cord-020235-stcrozdw 776 14 from from IN cord-020235-stcrozdw 776 15 mixtures mixture NNS cord-020235-stcrozdw 776 16 of of IN cord-020235-stcrozdw 776 17 avirulent avirulent NN cord-020235-stcrozdw 776 18 influenza influenza NN cord-020235-stcrozdw 776 19 A A NNP cord-020235-stcrozdw 776 20 - - HYPH cord-020235-stcrozdw 776 21 viruses virus NNS cord-020235-stcrozdw 776 22 provided provide VBD cord-020235-stcrozdw 776 23 one one CD cord-020235-stcrozdw 776 24 of of IN cord-020235-stcrozdw 776 25 the the DT cord-020235-stcrozdw 776 26 parents parent NNS cord-020235-stcrozdw 776 27 had have VBD cord-020235-stcrozdw 776 28 previously previously RB cord-020235-stcrozdw 776 29 been be VBN cord-020235-stcrozdw 776 30 adapted adapt VBN cord-020235-stcrozdw 776 31 to to IN cord-020235-stcrozdw 776 32 that that DT cord-020235-stcrozdw 776 33 host host NN cord-020235-stcrozdw 776 34 . . . cord-020235-stcrozdw 777 1 This this DT cord-020235-stcrozdw 777 2 study study NN cord-020235-stcrozdw 777 3 shows show VBZ cord-020235-stcrozdw 777 4 that that IN cord-020235-stcrozdw 777 5 prior prior JJ cord-020235-stcrozdw 777 6 adaptation adaptation NN cord-020235-stcrozdw 777 7 of of IN cord-020235-stcrozdw 777 8 parental parental JJ cord-020235-stcrozdw 777 9 strains strain NNS cord-020235-stcrozdw 777 10 is be VBZ cord-020235-stcrozdw 777 11 not not RB cord-020235-stcrozdw 777 12 necessary necessary JJ cord-020235-stcrozdw 777 13 and and CC cord-020235-stcrozdw 777 14 that that DT cord-020235-stcrozdw 777 15 generation generation NN cord-020235-stcrozdw 777 16 of of IN cord-020235-stcrozdw 777 17 neurovirulent neurovirulent NN cord-020235-stcrozdw 777 18 recombinants recombinant NNS cord-020235-stcrozdw 777 19 is be VBZ cord-020235-stcrozdw 777 20 frequent frequent JJ cord-020235-stcrozdw 777 21 . . . cord-020235-stcrozdw 778 1 The the DT cord-020235-stcrozdw 778 2 gene gene NN cord-020235-stcrozdw 778 3 constellation constellation NN cord-020235-stcrozdw 778 4 for for IN cord-020235-stcrozdw 778 5 neurovirulence neurovirulence NNP cord-020235-stcrozdw 778 6 was be VBD cord-020235-stcrozdw 778 7 predictible predictible JJ cord-020235-stcrozdw 778 8 for for IN cord-020235-stcrozdw 778 9 recombinants recombinant NNS cord-020235-stcrozdw 778 10 derived derive VBN cord-020235-stcrozdw 778 11 from from IN cord-020235-stcrozdw 778 12 a a DT cord-020235-stcrozdw 778 13 particular particular JJ cord-020235-stcrozdw 778 14 pair pair NN cord-020235-stcrozdw 778 15 of of IN cord-020235-stcrozdw 778 16 parental parental JJ cord-020235-stcrozdw 778 17 strains strain NNS cord-020235-stcrozdw 778 18 In in IN cord-020235-stcrozdw 778 19 influenza influenza NN cord-020235-stcrozdw 778 20 C c NN cord-020235-stcrozdw 778 21 virus virus NN cord-020235-stcrozdw 778 22 -infected -infecte VBD cord-020235-stcrozdw 778 23 cells cell NNS cord-020235-stcrozdw 778 24 a a DT cord-020235-stcrozdw 778 25 virus virus NN cord-020235-stcrozdw 778 26 - - HYPH cord-020235-stcrozdw 778 27 specific specific JJ cord-020235-stcrozdw 778 28 protein protein NN cord-020235-stcrozdw 778 29 of of IN cord-020235-stcrozdw 778 30 a a DT cord-020235-stcrozdw 778 31 molecular molecular JJ cord-020235-stcrozdw 778 32 weight weight NN cord-020235-stcrozdw 778 33 of of IN cord-020235-stcrozdw 778 34 65,000 65,000 CD cord-020235-stcrozdw 778 35 Dalton Dalton NNP cord-020235-stcrozdw 778 36 can can MD cord-020235-stcrozdw 778 37 be be VB cord-020235-stcrozdw 778 38 detected detect VBN cord-020235-stcrozdw 778 39 when when WRB cord-020235-stcrozdw 778 40 glycosylation glycosylation NN cord-020235-stcrozdw 778 41 is be VBZ cord-020235-stcrozdw 778 42 inhibited inhibit VBN cord-020235-stcrozdw 778 43 by by IN cord-020235-stcrozdw 778 44 Tunicamycin Tunicamycin NNP cord-020235-stcrozdw 778 45 . . . cord-020235-stcrozdw 779 1 Since since IN cord-020235-stcrozdw 779 2 this this DT cord-020235-stcrozdw 779 3 protein protein NN cord-020235-stcrozdw 779 4 can can MD cord-020235-stcrozdw 779 5 not not RB cord-020235-stcrozdw 779 6 be be VB cord-020235-stcrozdw 779 7 found find VBN cord-020235-stcrozdw 779 8 in in IN cord-020235-stcrozdw 779 9 untreated untreated JJ cord-020235-stcrozdw 779 10 control control NN cord-020235-stcrozdw 779 11 cells cell NNS cord-020235-stcrozdw 779 12 , , , cord-020235-stcrozdw 779 13 it -PRON- PRP cord-020235-stcrozdw 779 14 probably probably RB cord-020235-stcrozdw 779 15 constitutes constitute VBZ cord-020235-stcrozdw 779 16 the the DT cord-020235-stcrozdw 779 17 unglycosylated unglycosylated JJ cord-020235-stcrozdw 779 18 precursor precursor NN cord-020235-stcrozdw 779 19 of of IN cord-020235-stcrozdw 779 20 the the DT cord-020235-stcrozdw 779 21 viral viral JJ cord-020235-stcrozdw 779 22 glycoprotein glycoprotein NN cord-020235-stcrozdw 779 23 gp gp NN cord-020235-stcrozdw 779 24 88 88 CD cord-020235-stcrozdw 779 25 Since since IN cord-020235-stcrozdw 779 26 the the DT cord-020235-stcrozdw 779 27 petide petide NN cord-020235-stcrozdw 779 28 pattern pattern NN cord-020235-stcrozdw 779 29 is be VBZ cord-020235-stcrozdw 779 30 identical identical JJ cord-020235-stcrozdw 779 31 for for IN cord-020235-stcrozdw 779 32 the the DT cord-020235-stcrozdw 779 33 doublet doublet NN cord-020235-stcrozdw 779 34 bands band NNS cord-020235-stcrozdw 779 35 , , , cord-020235-stcrozdw 779 36 it -PRON- PRP cord-020235-stcrozdw 779 37 remains remain VBZ cord-020235-stcrozdw 779 38 to to TO cord-020235-stcrozdw 779 39 be be VB cord-020235-stcrozdw 779 40 established establish VBN cord-020235-stcrozdw 779 41 whether whether IN cord-020235-stcrozdw 779 42 this this DT cord-020235-stcrozdw 779 43 reflects reflect VBZ cord-020235-stcrozdw 779 44 a a DT cord-020235-stcrozdw 779 45 differential differential JJ cord-020235-stcrozdw 779 46 glycosylation glycosylation NN cord-020235-stcrozdw 779 47 or or CC cord-020235-stcrozdw 779 48 dissimilar dissimilar JJ cord-020235-stcrozdw 779 49 proteolytic proteolytic JJ cord-020235-stcrozdw 779 50 cleavage cleavage NN cord-020235-stcrozdw 779 51 sites site NNS cord-020235-stcrozdw 779 52 . . . cord-020235-stcrozdw 780 1 The the DT cord-020235-stcrozdw 780 2 coding code VBG cord-020235-stcrozdw 780 3 capacity capacity NN cord-020235-stcrozdw 780 4 of of IN cord-020235-stcrozdw 780 5 the the DT cord-020235-stcrozdw 780 6 viral viral JJ cord-020235-stcrozdw 780 7 genome genome NN cord-020235-stcrozdw 780 8 RNA rna NN cord-020235-stcrozdw 780 9 - - HYPH cord-020235-stcrozdw 780 10 segment segment NN cord-020235-stcrozdw 781 1 No no DT cord-020235-stcrozdw 781 2 Abstracts abstract NNS cord-020235-stcrozdw 781 3 of of IN cord-020235-stcrozdw 781 4 the the DT cord-020235-stcrozdw 781 5 38th 38th JJ cord-020235-stcrozdw 781 6 Meeting Meeting NNP cord-020235-stcrozdw 781 7 of of IN cord-020235-stcrozdw 781 8 the the DT cord-020235-stcrozdw 781 9 OGHM OGHM NNP cord-020235-stcrozdw 781 10 1 1 CD cord-020235-stcrozdw 781 11 Augenklinik Augenklinik NNP cord-020235-stcrozdw 781 12 d. d. NNP cord-020235-stcrozdw 781 13 justus justus NNP cord-020235-stcrozdw 781 14 - - HYPH cord-020235-stcrozdw 781 15 Liebig Liebig NNP cord-020235-stcrozdw 781 16 - - HYPH cord-020235-stcrozdw 781 17 Univ Univ NNP cord-020235-stcrozdw 781 18 . . . cord-020235-stcrozdw 782 1 , , , cord-020235-stcrozdw 782 2 0 0 CD cord-020235-stcrozdw 782 3 - - HYPH cord-020235-stcrozdw 782 4 6300 6300 CD cord-020235-stcrozdw 782 5 Giessen Giessen NNP cord-020235-stcrozdw 782 6 ; ; : cord-020235-stcrozdw 782 7 2 2 CD cord-020235-stcrozdw 782 8 Inst Inst NNP cord-020235-stcrozdw 782 9 . . . cord-020235-stcrozdw 782 10 f. f. NN cord-020235-stcrozdw 782 11 Neuropathologie Neuropathologie NNP cord-020235-stcrozdw 782 12 u. u. NNP cord-020235-stcrozdw 782 13 Virologie Virologie NNP cord-020235-stcrozdw 782 14 , , , cord-020235-stcrozdw 782 15 Freie Freie NNP cord-020235-stcrozdw 782 16 Univ Univ NNP cord-020235-stcrozdw 782 17 . . NNP cord-020235-stcrozdw 782 18 , , , cord-020235-stcrozdw 782 19 0 0 CD cord-020235-stcrozdw 782 20 - - SYM cord-020235-stcrozdw 782 21 1000 1000 CD cord-020235-stcrozdw 782 22 Berlin Berlin NNP cord-020235-stcrozdw 782 23 Retino Retino NNP cord-020235-stcrozdw 782 24 - - HYPH cord-020235-stcrozdw 782 25 Cerebral Cerebral NNP cord-020235-stcrozdw 782 26 Manifestation Manifestation NNP cord-020235-stcrozdw 782 27 of of IN cord-020235-stcrozdw 782 28 Experimental Experimental NNP cord-020235-stcrozdw 782 29 Borna Borna NNP cord-020235-stcrozdw 782 30 Disease Disease NNP cord-020235-stcrozdw 782 31 In in IN cord-020235-stcrozdw 782 32 Rhesus Rhesus NNP cord-020235-stcrozdw 782 33 Monkeys Monkeys NNP cord-020235-stcrozdw 782 34 KREY KREY NNP cord-020235-stcrozdw 782 35 , , , cord-020235-stcrozdw 782 36 H.t H.t NNP cord-020235-stcrozdw 782 37 , , , cord-020235-stcrozdw 782 38 ROGGENDORF ROGGENDORF NNP cord-020235-stcrozdw 782 39 , , , cord-020235-stcrozdw 782 40 W.2 W.2 NNP cord-020235-stcrozdw 782 41 , , , cord-020235-stcrozdw 782 42 and and CC cord-020235-stcrozdw 782 43 LUDWIG LUDWIG NNP cord-020235-stcrozdw 782 44 , , , cord-020235-stcrozdw 782 45 H.3 h.3 NN cord-020235-stcrozdw 782 46 Inflammation inflammation NN cord-020235-stcrozdw 782 47 of of IN cord-020235-stcrozdw 782 48 the the DT cord-020235-stcrozdw 782 49 uveal uveal JJ cord-020235-stcrozdw 782 50 tract tract NN cord-020235-stcrozdw 782 51 , , , cord-020235-stcrozdw 782 52 the the DT cord-020235-stcrozdw 782 53 retina retina NN cord-020235-stcrozdw 782 54 meninges meninge NNS cord-020235-stcrozdw 782 55 and and CC cord-020235-stcrozdw 782 56 brain brain NN cord-020235-stcrozdw 782 57 represent represent VBP cord-020235-stcrozdw 782 58 uveo uveo NN cord-020235-stcrozdw 782 59 - - HYPH cord-020235-stcrozdw 782 60 meningoencephalitic meningoencephalitic JJ cord-020235-stcrozdw 782 61 syndromes syndrome NNS cord-020235-stcrozdw 782 62 of of IN cord-020235-stcrozdw 782 63 unknown unknown JJ cord-020235-stcrozdw 782 64 origin origin NN cord-020235-stcrozdw 782 65 . . . cord-020235-stcrozdw 783 1 One one CD cord-020235-stcrozdw 783 2 of of IN cord-020235-stcrozdw 783 3 these these DT cord-020235-stcrozdw 783 4 , , , cord-020235-stcrozdw 783 5 the the DT cord-020235-stcrozdw 783 6 Vogt Vogt NNP cord-020235-stcrozdw 783 7 - - HYPH cord-020235-stcrozdw 783 8 Koyanagi Koyanagi NNP cord-020235-stcrozdw 783 9 - - HYPH cord-020235-stcrozdw 783 10 Harada Harada NNP cord-020235-stcrozdw 783 11 syndrome syndrome NN cord-020235-stcrozdw 783 12 is be VBZ cord-020235-stcrozdw 783 13 primarily primarily RB cord-020235-stcrozdw 783 14 manifested manifest VBN cord-020235-stcrozdw 783 15 by by IN cord-020235-stcrozdw 783 16 inflammation inflammation NN cord-020235-stcrozdw 783 17 of of IN cord-020235-stcrozdw 783 18 the the DT cord-020235-stcrozdw 783 19 retinal retinal JJ cord-020235-stcrozdw 783 20 pigment pigment NN cord-020235-stcrozdw 783 21 epithelium epithelium NN cord-020235-stcrozdw 783 22 , , , cord-020235-stcrozdw 783 23 the the DT cord-020235-stcrozdw 783 24 uveal uveal JJ cord-020235-stcrozdw 783 25 tract tract NN cord-020235-stcrozdw 783 26 and and CC cord-020235-stcrozdw 783 27 meninges meninge NNS cord-020235-stcrozdw 783 28 . . . cord-020235-stcrozdw 784 1 Severe severe JJ cord-020235-stcrozdw 784 2 visual visual JJ cord-020235-stcrozdw 784 3 and and CC cord-020235-stcrozdw 784 4 neurological neurological JJ cord-020235-stcrozdw 784 5 impairment impairment NN cord-020235-stcrozdw 784 6 can can MD cord-020235-stcrozdw 784 7 occur occur VB cord-020235-stcrozdw 784 8 . . . cord-020235-stcrozdw 785 1 In in IN cord-020235-stcrozdw 785 2 our -PRON- PRP$ cord-020235-stcrozdw 785 3 experimental experimental JJ cord-020235-stcrozdw 785 4 studies study NNS cord-020235-stcrozdw 785 5 14 14 CD cord-020235-stcrozdw 785 6 rhesus rhesu NNS cord-020235-stcrozdw 785 7 monkeys monkey NNS cord-020235-stcrozdw 785 8 were be VBD cord-020235-stcrozdw 785 9 experimentally experimentally RB cord-020235-stcrozdw 785 10 infected infect VBN cord-020235-stcrozdw 785 11 with with IN cord-020235-stcrozdw 785 12 Borna Borna NNP cord-020235-stcrozdw 785 13 disease disease NN cord-020235-stcrozdw 785 14 virus virus NN cord-020235-stcrozdw 785 15 . . . cord-020235-stcrozdw 786 1 After after IN cord-020235-stcrozdw 786 2 a a DT cord-020235-stcrozdw 786 3 4 4 CD cord-020235-stcrozdw 786 4 - - SYM cord-020235-stcrozdw 786 5 7 7 CD cord-020235-stcrozdw 786 6 week week NN cord-020235-stcrozdw 786 7 incubation incubation NN cord-020235-stcrozdw 786 8 period period NN cord-020235-stcrozdw 786 9 a a DT cord-020235-stcrozdw 786 10 progressive progressive JJ cord-020235-stcrozdw 786 11 retino retino JJ cord-020235-stcrozdw 786 12 - - HYPH cord-020235-stcrozdw 786 13 cerebral cerebral JJ cord-020235-stcrozdw 786 14 syndrome syndrome NN cord-020235-stcrozdw 786 15 was be VBD cord-020235-stcrozdw 786 16 observed observe VBN cord-020235-stcrozdw 786 17 . . . cord-020235-stcrozdw 787 1 Focal focal JJ cord-020235-stcrozdw 787 2 inflammatory inflammatory JJ cord-020235-stcrozdw 787 3 lesions lesion NNS cord-020235-stcrozdw 787 4 in in IN cord-020235-stcrozdw 787 5 the the DT cord-020235-stcrozdw 787 6 retinal retinal JJ cord-020235-stcrozdw 787 7 pigmentepithelium pigmentepithelium NN cord-020235-stcrozdw 787 8 and and CC cord-020235-stcrozdw 787 9 the the DT cord-020235-stcrozdw 787 10 uveal uveal JJ cord-020235-stcrozdw 787 11 tract tract NN cord-020235-stcrozdw 787 12 were be VBD cord-020235-stcrozdw 787 13 accompanied accompany VBN cord-020235-stcrozdw 787 14 by by IN cord-020235-stcrozdw 787 15 encephalitic encephalitic JJ cord-020235-stcrozdw 787 16 and and CC cord-020235-stcrozdw 787 17 meningeal meningeal JJ cord-020235-stcrozdw 787 18 infiltrates infiltrate NNS cord-020235-stcrozdw 787 19 . . . cord-020235-stcrozdw 788 1 Infectious infectious JJ cord-020235-stcrozdw 788 2 virus virus NN cord-020235-stcrozdw 788 3 could could MD cord-020235-stcrozdw 788 4 be be VB cord-020235-stcrozdw 788 5 demonstrated demonstrate VBN cord-020235-stcrozdw 788 6 in in IN cord-020235-stcrozdw 788 7 the the DT cord-020235-stcrozdw 788 8 retina retina NN cord-020235-stcrozdw 788 9 and and CC cord-020235-stcrozdw 788 10 in in IN cord-020235-stcrozdw 788 11 the the DT cord-020235-stcrozdw 788 12 brain brain NN cord-020235-stcrozdw 788 13 . . . cord-020235-stcrozdw 789 1 Experimental Experimental NNP cord-020235-stcrozdw 789 2 Borna Borna NNP cord-020235-stcrozdw 789 3 disease disease NN cord-020235-stcrozdw 789 4 can can MD cord-020235-stcrozdw 789 5 serve serve VB cord-020235-stcrozdw 789 6 as as IN cord-020235-stcrozdw 789 7 an an DT cord-020235-stcrozdw 789 8 appropriate appropriate JJ cord-020235-stcrozdw 789 9 model model NN cord-020235-stcrozdw 789 10 for for IN cord-020235-stcrozdw 789 11 uveo uveo NN cord-020235-stcrozdw 789 12 - - HYPH cord-020235-stcrozdw 789 13 meningo meningo NN cord-020235-stcrozdw 789 14 - - HYPH cord-020235-stcrozdw 789 15 encephalitic encephalitic JJ cord-020235-stcrozdw 789 16 syndromes syndrome NNS cord-020235-stcrozdw 789 17 in in IN cord-020235-stcrozdw 789 18 men man NNS cord-020235-stcrozdw 789 19 . . . cord-020235-stcrozdw 790 1 Borna Borna NNP cord-020235-stcrozdw 790 2 Disease Disease NNP cord-020235-stcrozdw 790 3 ( ( -LRB- cord-020235-stcrozdw 790 4 BO BO NNP cord-020235-stcrozdw 790 5 ) ) -RRB- cord-020235-stcrozdw 790 6 virus virus NN cord-020235-stcrozdw 790 7 induced induce VBN cord-020235-stcrozdw 790 8 encephalitis encephalitis RB cord-020235-stcrozdw 790 9 in in IN cord-020235-stcrozdw 790 10 horses horse NNS cord-020235-stcrozdw 790 11 , , , cord-020235-stcrozdw 790 12 sheep sheep NNS cord-020235-stcrozdw 790 13 , , , cord-020235-stcrozdw 790 14 rodents rodent NNS cord-020235-stcrozdw 790 15 and and CC cord-020235-stcrozdw 790 16 primates primate NNS cord-020235-stcrozdw 790 17 shows show VBZ cord-020235-stcrozdw 790 18 similarities similarity NNS cord-020235-stcrozdw 790 19 in in IN cord-020235-stcrozdw 790 20 many many JJ cord-020235-stcrozdw 790 21 aspects aspect NNS cord-020235-stcrozdw 790 22 with with IN cord-020235-stcrozdw 790 23 other other JJ cord-020235-stcrozdw 790 24 so so RB cord-020235-stcrozdw 790 25 - - HYPH cord-020235-stcrozdw 790 26 called call VBN cord-020235-stcrozdw 790 27 slow slow JJ cord-020235-stcrozdw 790 28 virus virus NN cord-020235-stcrozdw 790 29 diseases disease NNS cord-020235-stcrozdw 790 30 . . . cord-020235-stcrozdw 791 1 The the DT cord-020235-stcrozdw 791 2 EEG EEG NNP cord-020235-stcrozdw 791 3 has have VBZ cord-020235-stcrozdw 791 4 shown show VBN cord-020235-stcrozdw 791 5 to to TO cord-020235-stcrozdw 791 6 be be VB cord-020235-stcrozdw 791 7 a a DT cord-020235-stcrozdw 791 8 specific specific JJ cord-020235-stcrozdw 791 9 tool tool NN cord-020235-stcrozdw 791 10 in in IN cord-020235-stcrozdw 791 11 studying study VBG cord-020235-stcrozdw 791 12 encephalitides encephalitis NNS cord-020235-stcrozdw 791 13 of of IN cord-020235-stcrozdw 791 14 different different JJ cord-020235-stcrozdw 791 15 types type NNS cord-020235-stcrozdw 791 16 in in IN cord-020235-stcrozdw 791 17 man man NN cord-020235-stcrozdw 791 18 . . . cord-020235-stcrozdw 792 1 This this DT cord-020235-stcrozdw 792 2 is be VBZ cord-020235-stcrozdw 792 3 a a DT cord-020235-stcrozdw 792 4 report report NN cord-020235-stcrozdw 792 5 on on IN cord-020235-stcrozdw 792 6 the the DT cord-020235-stcrozdw 792 7 EEG EEG NNP cord-020235-stcrozdw 792 8 of of IN cord-020235-stcrozdw 792 9 the the DT cord-020235-stcrozdw 792 10 BO BO NNP cord-020235-stcrozdw 792 11 virus virus NN cord-020235-stcrozdw 792 12 specific specific JJ cord-020235-stcrozdw 792 13 encephalitis encephalitis RB cord-020235-stcrozdw 792 14 . . . cord-020235-stcrozdw 793 1 Twenty twenty CD cord-020235-stcrozdw 793 2 - - HYPH cord-020235-stcrozdw 793 3 eight eight CD cord-020235-stcrozdw 793 4 rabbits rabbit NNS cord-020235-stcrozdw 793 5 inoculated inoculate VBN cord-020235-stcrozdw 793 6 by by IN cord-020235-stcrozdw 793 7 different different JJ cord-020235-stcrozdw 793 8 routes route NNS cord-020235-stcrozdw 793 9 and and CC cord-020235-stcrozdw 793 10 with with IN cord-020235-stcrozdw 793 11 different different JJ cord-020235-stcrozdw 793 12 virus virus NN cord-020235-stcrozdw 793 13 preparations preparation NNS cord-020235-stcrozdw 793 14 were be VBD cord-020235-stcrozdw 793 15 screened screen VBN cord-020235-stcrozdw 793 16 for for IN cord-020235-stcrozdw 793 17 EEG EEG NNP cord-020235-stcrozdw 793 18 changes change NNS cord-020235-stcrozdw 793 19 . . . cord-020235-stcrozdw 794 1 The the DT cord-020235-stcrozdw 794 2 basic basic JJ cord-020235-stcrozdw 794 3 frequency frequency NN cord-020235-stcrozdw 794 4 was be VBD cord-020235-stcrozdw 794 5 measured measure VBN cord-020235-stcrozdw 794 6 optically optically RB cord-020235-stcrozdw 794 7 and and CC cord-020235-stcrozdw 794 8 an an DT cord-020235-stcrozdw 794 9 analysis analysis NN cord-020235-stcrozdw 794 10 of of IN cord-020235-stcrozdw 794 11 the the DT cord-020235-stcrozdw 794 12 EEG EEG NNP cord-020235-stcrozdw 794 13 was be VBD cord-020235-stcrozdw 794 14 performed perform VBN cord-020235-stcrozdw 794 15 . . . cord-020235-stcrozdw 795 1 The the DT cord-020235-stcrozdw 795 2 following follow VBG cord-020235-stcrozdw 795 3 conclusions conclusion NNS cord-020235-stcrozdw 795 4 were be VBD cord-020235-stcrozdw 795 5 made make VBN cord-020235-stcrozdw 795 6 : : : cord-020235-stcrozdw 795 7 1 1 LS cord-020235-stcrozdw 795 8 . . . cord-020235-stcrozdw 796 1 A a DT cord-020235-stcrozdw 796 2 significant significant JJ cord-020235-stcrozdw 796 3 slowing slowing NN cord-020235-stcrozdw 796 4 down down RP cord-020235-stcrozdw 796 5 of of IN cord-020235-stcrozdw 796 6 the the DT cord-020235-stcrozdw 796 7 basic basic JJ cord-020235-stcrozdw 796 8 frequency frequency NN cord-020235-stcrozdw 796 9 was be VBD cord-020235-stcrozdw 796 10 observed observe VBN cord-020235-stcrozdw 796 11 in in IN cord-020235-stcrozdw 796 12 the the DT cord-020235-stcrozdw 796 13 EEGs eeg NNS cord-020235-stcrozdw 796 14 of of IN cord-020235-stcrozdw 796 15 BO BO NNP cord-020235-stcrozdw 796 16 virus virus NN cord-020235-stcrozdw 796 17 infected infect VBN cord-020235-stcrozdw 796 18 rabbits rabbit NNS cord-020235-stcrozdw 796 19 . . . cord-020235-stcrozdw 797 1 2 2 LS cord-020235-stcrozdw 797 2 . . . cord-020235-stcrozdw 798 1 Spikes spike NNS cord-020235-stcrozdw 798 2 and and CC cord-020235-stcrozdw 798 3 spike spike NN cord-020235-stcrozdw 798 4 - - HYPH cord-020235-stcrozdw 798 5 waves wave NNS cord-020235-stcrozdw 798 6 were be VBD cord-020235-stcrozdw 798 7 present present JJ cord-020235-stcrozdw 798 8 rather rather RB cord-020235-stcrozdw 798 9 regularly regularly RB cord-020235-stcrozdw 798 10 and and CC cord-020235-stcrozdw 798 11 correlated correlate VBN cord-020235-stcrozdw 798 12 with with IN cord-020235-stcrozdw 798 13 epileptic epileptic JJ cord-020235-stcrozdw 798 14 seizures seizure NNS cord-020235-stcrozdw 798 15 at at IN cord-020235-stcrozdw 798 16 the the DT cord-020235-stcrozdw 798 17 end end NN cord-020235-stcrozdw 798 18 of of IN cord-020235-stcrozdw 798 19 the the DT cord-020235-stcrozdw 798 20 disease disease NN cord-020235-stcrozdw 798 21 when when WRB cord-020235-stcrozdw 798 22 they -PRON- PRP cord-020235-stcrozdw 798 23 appeared appear VBD cord-020235-stcrozdw 798 24 rhythmically rhythmically RB cord-020235-stcrozdw 798 25 in in IN cord-020235-stcrozdw 798 26 intervalls intervall NNS cord-020235-stcrozdw 798 27 of of IN cord-020235-stcrozdw 798 28 twenty twenty CD cord-020235-stcrozdw 798 29 seconds second NNS cord-020235-stcrozdw 798 30 . . . cord-020235-stcrozdw 799 1 Rademakercomplexes Rademakercomplexes NNP cord-020235-stcrozdw 799 2 appeared appear VBD cord-020235-stcrozdw 799 3 from from IN cord-020235-stcrozdw 799 4 the the DT cord-020235-stcrozdw 799 5 third third JJ cord-020235-stcrozdw 799 6 week week NN cord-020235-stcrozdw 799 7 on on IN cord-020235-stcrozdw 799 8 . . . cord-020235-stcrozdw 800 1 Virological virological JJ cord-020235-stcrozdw 800 2 and and CC cord-020235-stcrozdw 800 3 serological serological JJ cord-020235-stcrozdw 800 4 data datum NNS cord-020235-stcrozdw 800 5 collected collect VBN cord-020235-stcrozdw 800 6 from from IN cord-020235-stcrozdw 800 7 all all DT cord-020235-stcrozdw 800 8 animals animal NNS cord-020235-stcrozdw 800 9 demonstrated demonstrate VBD cord-020235-stcrozdw 800 10 a a DT cord-020235-stcrozdw 800 11 strong strong JJ cord-020235-stcrozdw 800 12 correlation correlation NN cord-020235-stcrozdw 800 13 of of IN cord-020235-stcrozdw 800 14 BO BO NNP cord-020235-stcrozdw 800 15 virus virus NN cord-020235-stcrozdw 800 16 specific specific JJ cord-020235-stcrozdw 800 17 reactions reaction NNS cord-020235-stcrozdw 800 18 with with IN cord-020235-stcrozdw 800 19 the the DT cord-020235-stcrozdw 800 20 EEG EEG NNP cord-020235-stcrozdw 800 21 alterations alteration NNS cord-020235-stcrozdw 800 22 . . . cord-020235-stcrozdw 801 1 The the DT cord-020235-stcrozdw 801 2 patterns pattern NNS cord-020235-stcrozdw 801 3 of of IN cord-020235-stcrozdw 801 4 EEG EEG NNP cord-020235-stcrozdw 801 5 changes change NNS cord-020235-stcrozdw 801 6 are be VBP cord-020235-stcrozdw 801 7 reminiscent reminiscent JJ cord-020235-stcrozdw 801 8 of of IN cord-020235-stcrozdw 801 9 those those DT cord-020235-stcrozdw 801 10 in in IN cord-020235-stcrozdw 801 11 SSPE SSPE NNP cord-020235-stcrozdw 801 12 . . . cord-020235-stcrozdw 802 1 EEG EEG NNP cord-020235-stcrozdw 802 2 features feature VBZ cord-020235-stcrozdw 802 3 in in IN cord-020235-stcrozdw 802 4 this this DT cord-020235-stcrozdw 802 5 kind kind NN cord-020235-stcrozdw 802 6 of of IN cord-020235-stcrozdw 802 7 slow slow JJ cord-020235-stcrozdw 802 8 virus virus NN cord-020235-stcrozdw 802 9 diseases disease NNS cord-020235-stcrozdw 802 10 may may MD cord-020235-stcrozdw 802 11 have have VB cord-020235-stcrozdw 802 12 rather rather RB cord-020235-stcrozdw 802 13 similar similar JJ cord-020235-stcrozdw 802 14 characteristics characteristic NNS cord-020235-stcrozdw 802 15 which which WDT cord-020235-stcrozdw 802 16 could could MD cord-020235-stcrozdw 802 17 suggest suggest VB cord-020235-stcrozdw 802 18 that that IN cord-020235-stcrozdw 802 19 they -PRON- PRP cord-020235-stcrozdw 802 20 may may MD cord-020235-stcrozdw 802 21 underlie underlie VB cord-020235-stcrozdw 802 22 common common JJ cord-020235-stcrozdw 802 23 pathophysiological pathophysiological JJ cord-020235-stcrozdw 802 24 mechanism mechanism NN cord-020235-stcrozdw 802 25 . . . cord-020235-stcrozdw 803 1 We -PRON- PRP cord-020235-stcrozdw 803 2 established establish VBD cord-020235-stcrozdw 803 3 the the DT cord-020235-stcrozdw 803 4 primary primary JJ cord-020235-stcrozdw 803 5 cultures culture NNS cord-020235-stcrozdw 803 6 of of IN cord-020235-stcrozdw 803 7 neural neural JJ cord-020235-stcrozdw 803 8 retina retina NN cord-020235-stcrozdw 803 9 and and CC cord-020235-stcrozdw 803 10 pigment pigment NN cord-020235-stcrozdw 803 11 epithelium epithelium NN cord-020235-stcrozdw 803 12 of of IN cord-020235-stcrozdw 803 13 rabbit rabbit NN cord-020235-stcrozdw 803 14 and and CC cord-020235-stcrozdw 803 15 of of IN cord-020235-stcrozdw 803 16 the the DT cord-020235-stcrozdw 803 17 brain brain NN cord-020235-stcrozdw 803 18 of of IN cord-020235-stcrozdw 803 19 chicken chicken NN cord-020235-stcrozdw 803 20 embryo embryo NN cord-020235-stcrozdw 803 21 to to TO cord-020235-stcrozdw 803 22 study study VB cord-020235-stcrozdw 803 23 the the DT cord-020235-stcrozdw 803 24 sensitivity sensitivity NN cord-020235-stcrozdw 803 25 of of IN cord-020235-stcrozdw 803 26 each each DT cord-020235-stcrozdw 803 27 kind kind NN cord-020235-stcrozdw 803 28 of of IN cord-020235-stcrozdw 803 29 cells cell NNS cord-020235-stcrozdw 803 30 to to IN cord-020235-stcrozdw 803 31 the the DT