id author title date pages extension mime words sentences flesch summary cache txt cord-355913-fhvt1ht1 Burrell, Christopher J. Virus Replication 2016-11-11 .txt text/plain 9861 405 42 Little is known about what determines whether a given picornavirus positive-sense RNA molecule will be directed (1) to a replication complex (a structure bound to smooth endoplasmic reticulum), where it serves as template for transcription by RNA-dependent RNA polymerase into negative-sense RNA, or (2) to a ribosome, where it serves as mRNA for translation into protein, or (3) to a procapsid, with which it associates to form a virion. In the case of positive-sense single-stranded RNA viruses, the incoming RNA genome can bind directly to ribosomes and be translated in full or in part without the need for any prior transcription; all other forms of incoming viral RNA must first be transcribed to produce mRNA, in order to begin the process of expression of the infecting viral genome. ./cache/cord-355913-fhvt1ht1.txt ./txt/cord-355913-fhvt1ht1.txt