id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-332632-u2ud0vmq	Lussi, Carmela	What can pestiviral endonucleases teach us about innate immunotolerance?	2016-03-17		.txt	text/plain	8703	394	44	In particular, the unique extension of 'self' to include the viral genome by degrading immunostimulatory viral RNA by E(rns) is reminiscent of various host nucleases that are important to prevent inappropriate IFN activation by the host's own nucleic acids in autoimmune diseases such as Aicardi-Goutières syndrome or systemic lupus erythematosus. Thus, the survival strategy of BVDV consists of being non-cytopathogenic and producing less dsRNA than its cp counterpart, and expressing the IFN antagonists N pro as the first protein in order to reduce or even avoid IFN production in infected cells and E rns to degrade immunostimulatory viral RNA before they might activate the host's PRRs. Notably, both pestiviral IFN antagonists are not only required to constantly maintain innate immunotolerance during persistent infections, but they also play an important role in acute infections [25] .	./cache/cord-332632-u2ud0vmq.txt	./txt/cord-332632-u2ud0vmq.txt