id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-330684-3hxau5vt	Richard, A	Caspase cleavage of viral proteins, another way for viruses to make the best of apoptosis	2012-03-08		.txt	text/plain	4749	259	43	Several unrelated viruses have been described to take advantage of apoptosis induction by expressing proteins targeted by caspases, the key effectors of apoptotic cell death. Based on the well-described case of AMDV, we can In some cases, apoptosis induction by the host cell leads to exactly what is expected, namely viral attenuation, but surprisingly with the help of viral protein cleavages. However H-1PV is able to activate caspases in non-transformed cells, leading to the cleavage of NS1, a non-structural protein (NS) notably involved in viral DNA replication and gene expression by transactivating P38 promoter, which controls the synthesis of capsid proteins. In HRT18jap1 cells, the infection causes apoptosis but is not productive, suggesting that caspase activation (and possibly N caspase cleavage) prevents progeny virion generation. Induction of caspase activation and cleavage of the viral nucleocapsid protein in different cell types during Crimean-Congo hemorrhagic fever virus infection	./cache/cord-330684-3hxau5vt.txt	./txt/cord-330684-3hxau5vt.txt