id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-314024-n6l2804j	Gonçalves, Antonio	Timing of antiviral treatment initiation is critical to reduce SARS-Cov-2 viral load	2020-04-07		.txt	text/plain	2091	130	54	We modeled the viral dynamics of 13 untreated patients infected with SARS-CoV-2 to infer 39 viral growth parameters and predict the effects of antiviral treatments. We modeled the viral dynamics of 13 untreated patients infected with SARS-CoV-2 to infer 39 viral growth parameters and predict the effects of antiviral treatments. We 162 considered a simple case where the drug effectiveness is assumed to be constant after therapy 163 initiation (see methods) and we calculated the minimal efficacy that would be needed to 164 generate more than 2 logs of viral decline at peak viral load in the 13 studied patients (Fig. 1) . For a putative 167 treatment initiated at the time of infection, symptom onset, or 3 days post symptom onset, a 168 median efficacy of at least 60, 90 and 99% in reducing viral replication would be needed, 169 respectively, to generate more than 2 log of decline in the peak viral load (Fig. 1) .	./cache/cord-314024-n6l2804j.txt	./txt/cord-314024-n6l2804j.txt