id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293038-pjjvfdnq	Fontana, Juan	The unique architecture of Bunyamwera virus factories around the Golgi complex	2008-06-10		.txt	text/plain	7389	386	50	We propose that this new structure, unique among enveloped viruses, assembles in association with the most stable component of Golgi stacks, the actin‐containing matrix scaffold, connecting viral replication and morphogenesis inside viral factories. Modified membranes harbouring viral replication complexes (RCs) frequently integrate into a complex structure known as the 'viral factory' where the cytoskeleton participates, cell organelles are recruited and the different steps of the virus life cycle are sequentially connected. We propose that this new multifunctional structure associates with the actin-containing matrix of the Golgi stacks providing a stable scaffold for viral replication and early morphogenesis. LtA and CyD had very little or no effect, respectively, on viral replication and assembly as determined by measurement of infectious viral particles released to the culture supernatants at 6 and 10 h p.i. Complete tubes, virus budding profiles and viral particles assembled in Golgi stacks of cells treated with LtA, as observed in thin sections of treated cells studied by EM (not shown).	./cache/cord-293038-pjjvfdnq.txt	./txt/cord-293038-pjjvfdnq.txt