id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-018526-rz7id5mt	Braun, Serge	Non-viral Vector for Muscle-Mediated Gene Therapy	2018-12-14		.txt	text/plain	5181	228	37	Nevertheless, the local production of therapeutic proteins that may act distantly from the injected site and/or the hydrodynamic perfusion of safe plasmids remains a viable basis for the non-viral gene therapy of muscle disorders, cachexia, as well as peripheral neuropathies. In humans, intramuscular injections of naked plasmid encoding angiogenic factors (such as VEGF165 or HGF) were used in small numbers of patients with critical limb ischemia and did demonstrate promising clinical efficacy for the treatment of peripheral arterial disease. A meta-analysis of 12 clinical trials (1494 patients total) of local administration of pro-angiogenic growth factors (VEGF, FGF, HGF, Del-1, HIF-1alpha) using plasmid or viral gene transfer by intra-arterial or intramuscular injections showed that, despite promising results in single studies, no clear benefit could be identified in peripheral artery disease patients, irrespective of disease severity [51] .	./cache/cord-018526-rz7id5mt.txt	./txt/cord-018526-rz7id5mt.txt