id sid tid token lemma pos cord-304472-mi5v6512 1 1 key key NNP cord-304472-mi5v6512 1 2 : : : cord-304472-mi5v6512 1 3 cord-304472-mi5v6512 cord-304472-mi5v6512 NN cord-304472-mi5v6512 1 4 authors author NNS cord-304472-mi5v6512 1 5 : : : cord-304472-mi5v6512 1 6 Wilder Wilder NNP cord-304472-mi5v6512 1 7 - - HYPH cord-304472-mi5v6512 1 8 Smith Smith NNP cord-304472-mi5v6512 1 9 , , , cord-304472-mi5v6512 1 10 Annelies Annelies NNP cord-304472-mi5v6512 1 11 title title NN cord-304472-mi5v6512 1 12 : : : cord-304472-mi5v6512 1 13 Dengue dengue NN cord-304472-mi5v6512 1 14 vaccine vaccine NN cord-304472-mi5v6512 1 15 development development NN cord-304472-mi5v6512 1 16 by by IN cord-304472-mi5v6512 1 17 the the DT cord-304472-mi5v6512 1 18 year year NN cord-304472-mi5v6512 1 19 2020 2020 CD cord-304472-mi5v6512 1 20 : : : cord-304472-mi5v6512 1 21 challenges challenge NNS cord-304472-mi5v6512 1 22 and and CC cord-304472-mi5v6512 1 23 prospects prospect NNS cord-304472-mi5v6512 1 24 date date NN cord-304472-mi5v6512 1 25 : : : cord-304472-mi5v6512 1 26 2020 2020 CD cord-304472-mi5v6512 1 27 - - SYM cord-304472-mi5v6512 1 28 10 10 CD cord-304472-mi5v6512 1 29 - - SYM cord-304472-mi5v6512 1 30 18 18 CD cord-304472-mi5v6512 1 31 journal journal NN cord-304472-mi5v6512 1 32 : : : cord-304472-mi5v6512 2 1 Curr Curr NNP cord-304472-mi5v6512 2 2 Opin Opin NNP cord-304472-mi5v6512 3 1 Virol Virol NNP cord-304472-mi5v6512 3 2 DOI DOI NNP cord-304472-mi5v6512 3 3 : : : cord-304472-mi5v6512 3 4 10.1016 10.1016 CD cord-304472-mi5v6512 3 5 / / SYM cord-304472-mi5v6512 3 6 j.coviro.2020.09.004 j.coviro.2020.09.004 XX cord-304472-mi5v6512 4 1 sha sha NNP cord-304472-mi5v6512 4 2 : : : cord-304472-mi5v6512 5 1 f6533dc0f96cfa09d06a47c68a4f0a7b1c4544c5 f6533dc0f96cfa09d06a47c68a4f0a7b1c4544c5 LS cord-304472-mi5v6512 5 2 doc_id doc_id CD cord-304472-mi5v6512 5 3 : : : cord-304472-mi5v6512 5 4 304472 304472 CD cord-304472-mi5v6512 5 5 cord_uid cord_uid NNS cord-304472-mi5v6512 5 6 : : : cord-304472-mi5v6512 5 7 mi5v6512 mi5v6512 . cord-304472-mi5v6512 6 1 The the DT cord-304472-mi5v6512 6 2 first first JJ cord-304472-mi5v6512 6 3 licensed licensed JJ cord-304472-mi5v6512 6 4 dengue dengue NN cord-304472-mi5v6512 6 5 vaccine vaccine NN cord-304472-mi5v6512 6 6 led lead VBD cord-304472-mi5v6512 6 7 to to IN cord-304472-mi5v6512 6 8 considerable considerable JJ cord-304472-mi5v6512 6 9 controversy controversy NN cord-304472-mi5v6512 6 10 , , , cord-304472-mi5v6512 6 11 and and CC cord-304472-mi5v6512 6 12 to to IN cord-304472-mi5v6512 6 13 date date NN cord-304472-mi5v6512 6 14 , , , cord-304472-mi5v6512 6 15 no no DT cord-304472-mi5v6512 6 16 dengue dengue NN cord-304472-mi5v6512 6 17 vaccine vaccine NN cord-304472-mi5v6512 6 18 is be VBZ cord-304472-mi5v6512 6 19 in in IN cord-304472-mi5v6512 6 20 widespread widespread JJ cord-304472-mi5v6512 6 21 use use NN cord-304472-mi5v6512 6 22 . . . cord-304472-mi5v6512 7 1 All all DT cord-304472-mi5v6512 7 2 three three CD cord-304472-mi5v6512 7 3 leading lead VBG cord-304472-mi5v6512 7 4 dengue dengue NN cord-304472-mi5v6512 7 5 vaccine vaccine NN cord-304472-mi5v6512 7 6 candidates candidate NNS cord-304472-mi5v6512 7 7 are be VBP cord-304472-mi5v6512 7 8 live live RB cord-304472-mi5v6512 7 9 attenuated attenuated JJ cord-304472-mi5v6512 7 10 vaccines vaccine NNS cord-304472-mi5v6512 7 11 , , , cord-304472-mi5v6512 7 12 with with IN cord-304472-mi5v6512 7 13 the the DT cord-304472-mi5v6512 7 14 main main JJ cord-304472-mi5v6512 7 15 difference difference NN cord-304472-mi5v6512 7 16 between between IN cord-304472-mi5v6512 7 17 them -PRON- PRP cord-304472-mi5v6512 7 18 being be VBG cord-304472-mi5v6512 7 19 the the DT cord-304472-mi5v6512 7 20 type type NN cord-304472-mi5v6512 7 21 of of IN cord-304472-mi5v6512 7 22 backbone backbone NN cord-304472-mi5v6512 7 23 and and CC cord-304472-mi5v6512 7 24 the the DT cord-304472-mi5v6512 7 25 extent extent NN cord-304472-mi5v6512 7 26 of of IN cord-304472-mi5v6512 7 27 chimerization chimerization NN cord-304472-mi5v6512 7 28 . . . cord-304472-mi5v6512 8 1 While while IN cord-304472-mi5v6512 8 2 CYD CYD NNP cord-304472-mi5v6512 8 3 - - HYPH cord-304472-mi5v6512 8 4 TDV TDV NNP cord-304472-mi5v6512 8 5 ( ( -LRB- cord-304472-mi5v6512 8 6 the the DT cord-304472-mi5v6512 8 7 first first JJ cord-304472-mi5v6512 8 8 licensed licensed JJ cord-304472-mi5v6512 8 9 dengue dengue NN cord-304472-mi5v6512 8 10 vaccine vaccine NN cord-304472-mi5v6512 8 11 ) ) -RRB- cord-304472-mi5v6512 8 12 does do VBZ cord-304472-mi5v6512 8 13 not not RB cord-304472-mi5v6512 8 14 include include VB cord-304472-mi5v6512 8 15 non non JJ cord-304472-mi5v6512 8 16 - - JJ cord-304472-mi5v6512 8 17 structural structural JJ cord-304472-mi5v6512 8 18 proteins protein NNS cord-304472-mi5v6512 8 19 of of IN cord-304472-mi5v6512 8 20 dengue dengue NN cord-304472-mi5v6512 8 21 , , , cord-304472-mi5v6512 8 22 TAK-003 tak-003 NN cord-304472-mi5v6512 8 23 contains contain VBZ cord-304472-mi5v6512 8 24 the the DT cord-304472-mi5v6512 8 25 dengue dengue NN cord-304472-mi5v6512 8 26 virus virus NN cord-304472-mi5v6512 8 27 serotype serotype NN cord-304472-mi5v6512 8 28 2 2 CD cord-304472-mi5v6512 8 29 backbone backbone NN cord-304472-mi5v6512 8 30 , , , cord-304472-mi5v6512 8 31 and and CC cord-304472-mi5v6512 8 32 the the DT cord-304472-mi5v6512 8 33 Butantan Butantan NNP cord-304472-mi5v6512 8 34 / / SYM cord-304472-mi5v6512 8 35 Merck Merck NNP cord-304472-mi5v6512 8 36 vaccine vaccine NN cord-304472-mi5v6512 8 37 contains contain VBZ cord-304472-mi5v6512 8 38 three three CD cord-304472-mi5v6512 8 39 full full JJ cord-304472-mi5v6512 8 40 - - HYPH cord-304472-mi5v6512 8 41 genomes genome NNS cord-304472-mi5v6512 8 42 of of IN cord-304472-mi5v6512 8 43 the the DT cord-304472-mi5v6512 8 44 four four CD cord-304472-mi5v6512 8 45 dengue dengue NN cord-304472-mi5v6512 8 46 virus virus NN cord-304472-mi5v6512 8 47 serotypes serotype NNS cord-304472-mi5v6512 8 48 . . . cord-304472-mi5v6512 9 1 While while IN cord-304472-mi5v6512 9 2 dengue dengue NN cord-304472-mi5v6512 9 3 - - HYPH cord-304472-mi5v6512 9 4 primed prime VBN cord-304472-mi5v6512 9 5 individuals individual NNS cord-304472-mi5v6512 9 6 can can MD cord-304472-mi5v6512 9 7 already already RB cord-304472-mi5v6512 9 8 benefit benefit VB cord-304472-mi5v6512 9 9 from from IN cord-304472-mi5v6512 9 10 vaccination vaccination NN cord-304472-mi5v6512 9 11 against against IN cord-304472-mi5v6512 9 12 all all DT cord-304472-mi5v6512 9 13 four four CD cord-304472-mi5v6512 9 14 serotypes serotype NNS cord-304472-mi5v6512 9 15 with with IN cord-304472-mi5v6512 9 16 the the DT cord-304472-mi5v6512 9 17 first first JJ cord-304472-mi5v6512 9 18 licensed licensed JJ cord-304472-mi5v6512 9 19 dengue dengue NN cord-304472-mi5v6512 9 20 vaccine vaccine NN cord-304472-mi5v6512 9 21 CYD CYD NNP cord-304472-mi5v6512 9 22 - - HYPH cord-304472-mi5v6512 9 23 TDV TDV NNP cord-304472-mi5v6512 9 24 , , , cord-304472-mi5v6512 9 25 the the DT cord-304472-mi5v6512 9 26 need need NN cord-304472-mi5v6512 9 27 for for IN cord-304472-mi5v6512 9 28 dengue dengue NN cord-304472-mi5v6512 9 29 - - HYPH cord-304472-mi5v6512 9 30 naive naive JJ cord-304472-mi5v6512 9 31 population population NN cord-304472-mi5v6512 9 32 has have VBZ cord-304472-mi5v6512 9 33 not not RB cord-304472-mi5v6512 9 34 yet yet RB cord-304472-mi5v6512 9 35 been be VBN cord-304472-mi5v6512 9 36 met meet VBN cord-304472-mi5v6512 9 37 . . . cord-304472-mi5v6512 10 1 To to TO cord-304472-mi5v6512 10 2 improve improve VB cord-304472-mi5v6512 10 3 tetravalent tetravalent NN cord-304472-mi5v6512 10 4 protection protection NN cord-304472-mi5v6512 10 5 , , , cord-304472-mi5v6512 10 6 sequential sequential JJ cord-304472-mi5v6512 10 7 vaccination vaccination NN cord-304472-mi5v6512 10 8 should should MD cord-304472-mi5v6512 10 9 be be VB cord-304472-mi5v6512 10 10 considered consider VBN cord-304472-mi5v6512 10 11 in in IN cord-304472-mi5v6512 10 12 addition addition NN cord-304472-mi5v6512 10 13 to to IN cord-304472-mi5v6512 10 14 a a DT cord-304472-mi5v6512 10 15 heterologous heterologous JJ cord-304472-mi5v6512 10 16 prime prime JJ cord-304472-mi5v6512 10 17 - - HYPH cord-304472-mi5v6512 10 18 boost boost NN cord-304472-mi5v6512 10 19 approach approach NN cord-304472-mi5v6512 10 20 . . . cord-304472-mi5v6512 11 1 Dengue dengue NN cord-304472-mi5v6512 11 2 vaccine vaccine NN cord-304472-mi5v6512 11 3 development development NN cord-304472-mi5v6512 11 4 has have VBZ cord-304472-mi5v6512 11 5 been be VBN cord-304472-mi5v6512 11 6 hampered hamper VBN cord-304472-mi5v6512 11 7 and and CC cord-304472-mi5v6512 11 8 delayed delay VBN cord-304472-mi5v6512 11 9 by by IN cord-304472-mi5v6512 11 10 remarkable remarkable JJ cord-304472-mi5v6512 11 11 challenges challenge NNS cord-304472-mi5v6512 11 12 . . . cord-304472-mi5v6512 12 1 The the DT cord-304472-mi5v6512 12 2 four four CD cord-304472-mi5v6512 12 3 genetically genetically RB cord-304472-mi5v6512 12 4 succinct succinct JJ cord-304472-mi5v6512 12 5 but but CC cord-304472-mi5v6512 12 6 still still RB cord-304472-mi5v6512 12 7 closely closely RB cord-304472-mi5v6512 12 8 related related JJ cord-304472-mi5v6512 12 9 dengue dengue NN cord-304472-mi5v6512 12 10 serotypes serotype NNS cord-304472-mi5v6512 12 11 are be VBP cord-304472-mi5v6512 12 12 known know VBN cord-304472-mi5v6512 12 13 to to TO cord-304472-mi5v6512 12 14 interact interact VB cord-304472-mi5v6512 12 15 immunologically immunologically RB cord-304472-mi5v6512 12 16 with with IN cord-304472-mi5v6512 12 17 potential potential NN cord-304472-mi5v6512 12 18 for for IN cord-304472-mi5v6512 12 19 disease disease NN cord-304472-mi5v6512 12 20 enhancement enhancement NN cord-304472-mi5v6512 12 21 . . . cord-304472-mi5v6512 13 1 As as IN cord-304472-mi5v6512 13 2 a a DT cord-304472-mi5v6512 13 3 tetravalent tetravalent NN cord-304472-mi5v6512 13 4 immune immune JJ cord-304472-mi5v6512 13 5 response response NN cord-304472-mi5v6512 13 6 is be VBZ cord-304472-mi5v6512 13 7 desired desire VBN cord-304472-mi5v6512 13 8 , , , cord-304472-mi5v6512 13 9 when when WRB cord-304472-mi5v6512 13 10 given give VBN cord-304472-mi5v6512 13 11 a a DT cord-304472-mi5v6512 13 12 mixture mixture NN cord-304472-mi5v6512 13 13 of of IN cord-304472-mi5v6512 13 14 all all DT cord-304472-mi5v6512 13 15 four four CD cord-304472-mi5v6512 13 16 serotypes serotype NNS cord-304472-mi5v6512 13 17 in in IN cord-304472-mi5v6512 13 18 a a DT cord-304472-mi5v6512 13 19 tetravalent tetravalent NN cord-304472-mi5v6512 13 20 live live RB cord-304472-mi5v6512 13 21 - - HYPH cord-304472-mi5v6512 13 22 attenuated attenuated JJ cord-304472-mi5v6512 13 23 vaccine vaccine NN cord-304472-mi5v6512 13 24 , , , cord-304472-mi5v6512 13 25 each each DT cord-304472-mi5v6512 13 26 component component NN cord-304472-mi5v6512 13 27 would would MD cord-304472-mi5v6512 13 28 need need VB cord-304472-mi5v6512 13 29 to to TO cord-304472-mi5v6512 13 30 independently independently RB cord-304472-mi5v6512 13 31 result result VB cord-304472-mi5v6512 13 32 in in IN cord-304472-mi5v6512 13 33 four four CD cord-304472-mi5v6512 13 34 different different JJ cord-304472-mi5v6512 13 35 monotypic monotypic JJ cord-304472-mi5v6512 13 36 immune immune JJ cord-304472-mi5v6512 13 37 responses response NNS cord-304472-mi5v6512 13 38 that that WDT cord-304472-mi5v6512 13 39 are be VBP cord-304472-mi5v6512 13 40 solid solid JJ cord-304472-mi5v6512 13 41 to to IN cord-304472-mi5v6512 13 42 each each DT cord-304472-mi5v6512 13 43 serotype serotype NN cord-304472-mi5v6512 13 44 . . . cord-304472-mi5v6512 14 1 This this DT cord-304472-mi5v6512 14 2 has have VBZ cord-304472-mi5v6512 14 3 unfortunately unfortunately RB cord-304472-mi5v6512 14 4 proven prove VBN cord-304472-mi5v6512 14 5 to to TO cord-304472-mi5v6512 14 6 be be VB cord-304472-mi5v6512 14 7 difficult difficult JJ cord-304472-mi5v6512 14 8 to to TO cord-304472-mi5v6512 14 9 achieve achieve VB cord-304472-mi5v6512 14 10 . . . cord-304472-mi5v6512 15 1 Immune immune JJ cord-304472-mi5v6512 15 2 correlatestopredictprotectionversusdiseaseenhancement correlatestopredictprotectionversusdiseaseenhancement NN cord-304472-mi5v6512 15 3 are be VBP cord-304472-mi5v6512 15 4 still still RB cord-304472-mi5v6512 15 5 lacking lack VBG cord-304472-mi5v6512 15 6 [ [ -LRB- cord-304472-mi5v6512 15 7 1 1 CD cord-304472-mi5v6512 15 8 ] ] -RRB- cord-304472-mi5v6512 15 9 , , , cord-304472-mi5v6512 15 10 and and CC cord-304472-mi5v6512 15 11 plaque plaque NN cord-304472-mi5v6512 15 12 reduction reduction NN cord-304472-mi5v6512 15 13 neutralization neutralization NN cord-304472-mi5v6512 15 14 assays assay NNS cord-304472-mi5v6512 15 15 do do VBP cord-304472-mi5v6512 15 16 not not RB cord-304472-mi5v6512 15 17 reliably reliably RB cord-304472-mi5v6512 15 18 differentiate differentiate VB cord-304472-mi5v6512 15 19 between between IN cord-304472-mi5v6512 15 20 serotype serotype NN cord-304472-mi5v6512 15 21 - - HYPH cord-304472-mi5v6512 15 22 specific specific JJ cord-304472-mi5v6512 15 23 versus versus IN cord-304472-mi5v6512 15 24 heterotypic heterotypic NNP cord-304472-mi5v6512 15 25 antibodies antibody NNS cord-304472-mi5v6512 15 26 [ [ -LRB- cord-304472-mi5v6512 15 27 1,2 1,2 CD cord-304472-mi5v6512 15 28 ] ] -RRB- cord-304472-mi5v6512 15 29 . . . cord-304472-mi5v6512 16 1 Other other JJ cord-304472-mi5v6512 16 2 challenges challenge NNS cord-304472-mi5v6512 16 3 include include VBP cord-304472-mi5v6512 16 4 the the DT cord-304472-mi5v6512 16 5 lack lack NN cord-304472-mi5v6512 16 6 of of IN cord-304472-mi5v6512 16 7 a a DT cord-304472-mi5v6512 16 8 reliable reliable JJ cord-304472-mi5v6512 16 9 animal animal NN cord-304472-mi5v6512 16 10 model model NN cord-304472-mi5v6512 16 11 . . . cord-304472-mi5v6512 17 1 Furthermore furthermore RB cord-304472-mi5v6512 17 2 , , , cord-304472-mi5v6512 17 3 dengue dengue NN cord-304472-mi5v6512 17 4 is be VBZ cord-304472-mi5v6512 17 5 primarily primarily RB cord-304472-mi5v6512 17 6 a a DT cord-304472-mi5v6512 17 7 disease disease NN cord-304472-mi5v6512 17 8 of of IN cord-304472-mi5v6512 17 9 low low JJ cord-304472-mi5v6512 17 10 and and CC cord-304472-mi5v6512 17 11 middle middle JJ cord-304472-mi5v6512 17 12 income income NN cord-304472-mi5v6512 17 13 countries country NNS cord-304472-mi5v6512 17 14 , , , cord-304472-mi5v6512 17 15 thus thus RB cord-304472-mi5v6512 17 16 dengue dengue NN cord-304472-mi5v6512 17 17 research research NN cord-304472-mi5v6512 17 18 often often RB cord-304472-mi5v6512 17 19 does do VBZ cord-304472-mi5v6512 17 20 not not RB cord-304472-mi5v6512 17 21 receive receive VB cord-304472-mi5v6512 17 22 the the DT cord-304472-mi5v6512 17 23 level level NN cord-304472-mi5v6512 17 24 of of IN cord-304472-mi5v6512 17 25 funding funding NN cord-304472-mi5v6512 17 26 needed need VBN cord-304472-mi5v6512 17 27 to to TO cord-304472-mi5v6512 17 28 accelerate accelerate VB cord-304472-mi5v6512 17 29 vaccine vaccine NN cord-304472-mi5v6512 17 30 development development NN cord-304472-mi5v6512 17 31 [ [ -LRB- cord-304472-mi5v6512 17 32 3 3 CD cord-304472-mi5v6512 17 33 ] ] -RRB- cord-304472-mi5v6512 17 34 . . . cord-304472-mi5v6512 18 1 Unsurprisingly unsurprisingly RB cord-304472-mi5v6512 18 2 then then RB cord-304472-mi5v6512 18 3 , , , cord-304472-mi5v6512 18 4 it -PRON- PRP cord-304472-mi5v6512 18 5 has have VBZ cord-304472-mi5v6512 18 6 taken take VBN cord-304472-mi5v6512 18 7 several several JJ cord-304472-mi5v6512 18 8 decades decade NNS cord-304472-mi5v6512 18 9 to to TO cord-304472-mi5v6512 18 10 develop develop VB cord-304472-mi5v6512 18 11 a a DT cord-304472-mi5v6512 18 12 vaccine vaccine NN cord-304472-mi5v6512 18 13 . . . cord-304472-mi5v6512 19 1 The the DT cord-304472-mi5v6512 19 2 first first JJ cord-304472-mi5v6512 19 3 licensed licensed JJ cord-304472-mi5v6512 19 4 dengue dengue NN cord-304472-mi5v6512 19 5 vaccine vaccine NN cord-304472-mi5v6512 19 6 led lead VBN cord-304472-mi5v6512 19 7 to to IN cord-304472-mi5v6512 19 8 considerablecontroversy considerablecontroversy NNP cord-304472-mi5v6512 19 9 [ [ -LRB- cord-304472-mi5v6512 19 10 4 4 CD cord-304472-mi5v6512 19 11 ] ] -RRB- cord-304472-mi5v6512 19 12 , , , cord-304472-mi5v6512 19 13 andto andto NNP cord-304472-mi5v6512 19 14 date date NN cord-304472-mi5v6512 19 15 , , , cord-304472-mi5v6512 19 16 nodenguevaccine nodenguevaccine NNP cord-304472-mi5v6512 19 17 is be VBZ cord-304472-mi5v6512 19 18 in in IN cord-304472-mi5v6512 19 19 widespread widespread JJ cord-304472-mi5v6512 19 20 use use NN cord-304472-mi5v6512 19 21 . . . cord-304472-mi5v6512 20 1 Nevertheless nevertheless RB cord-304472-mi5v6512 20 2 , , , cord-304472-mi5v6512 20 3 we -PRON- PRP cord-304472-mi5v6512 20 4 need need VBP cord-304472-mi5v6512 20 5 to to TO cord-304472-mi5v6512 20 6 press press VB cord-304472-mi5v6512 20 7 on on IN cord-304472-mi5v6512 20 8 . . . cord-304472-mi5v6512 21 1 Dengue dengue NN cord-304472-mi5v6512 21 2 was be VBD cord-304472-mi5v6512 21 3 identified identify VBN cord-304472-mi5v6512 21 4 as as IN cord-304472-mi5v6512 21 5 one one CD cord-304472-mi5v6512 21 6 of of IN cord-304472-mi5v6512 21 7 the the DT cord-304472-mi5v6512 21 8 10 10 CD cord-304472-mi5v6512 21 9 threats threat NNS cord-304472-mi5v6512 21 10 to to IN cord-304472-mi5v6512 21 11 global global JJ cord-304472-mi5v6512 21 12 health health NN cord-304472-mi5v6512 21 13 in in IN cord-304472-mi5v6512 21 14 2019 2019 CD cord-304472-mi5v6512 21 15 by by IN cord-304472-mi5v6512 21 16 WHO WHO NNP cord-304472-mi5v6512 21 17 , , , cord-304472-mi5v6512 21 18 underlining underline VBG cord-304472-mi5v6512 21 19 the the DT cord-304472-mi5v6512 21 20 urgent urgent JJ cord-304472-mi5v6512 21 21 need need NN cord-304472-mi5v6512 21 22 for for IN cord-304472-mi5v6512 21 23 a a DT cord-304472-mi5v6512 21 24 vaccine vaccine NN cord-304472-mi5v6512 21 25 . . . cord-304472-mi5v6512 22 1 The the DT cord-304472-mi5v6512 22 2 primary primary JJ cord-304472-mi5v6512 22 3 need need NN cord-304472-mi5v6512 22 4 for for IN cord-304472-mi5v6512 22 5 a a DT cord-304472-mi5v6512 22 6 dengue dengue NN cord-304472-mi5v6512 22 7 vaccine vaccine NN cord-304472-mi5v6512 22 8 as as IN cord-304472-mi5v6512 22 9 a a DT cord-304472-mi5v6512 22 10 public public JJ cord-304472-mi5v6512 22 11 health health NN cord-304472-mi5v6512 22 12 tool tool NN cord-304472-mi5v6512 22 13 is be VBZ cord-304472-mi5v6512 22 14 the the DT cord-304472-mi5v6512 22 15 unpredictable unpredictable JJ cord-304472-mi5v6512 22 16 nature nature NN cord-304472-mi5v6512 22 17 of of IN cord-304472-mi5v6512 22 18 dengue dengue NN cord-304472-mi5v6512 22 19 outbreaks outbreak NNS cord-304472-mi5v6512 22 20 overwhelming overwhelming JJ cord-304472-mi5v6512 22 21 already already RB cord-304472-mi5v6512 22 22 existing exist VBG cord-304472-mi5v6512 22 23 fragile fragile JJ cord-304472-mi5v6512 22 24 health health NN cord-304472-mi5v6512 22 25 care care NN cord-304472-mi5v6512 22 26 systems system NNS cord-304472-mi5v6512 22 27 , , , cord-304472-mi5v6512 22 28 the the DT cord-304472-mi5v6512 22 29 extremely extremely RB cord-304472-mi5v6512 22 30 high high JJ cord-304472-mi5v6512 22 31 annual annual JJ cord-304472-mi5v6512 22 32 incidence incidence NN cord-304472-mi5v6512 22 33 of of IN cord-304472-mi5v6512 22 34 at at RB cord-304472-mi5v6512 22 35 least least RBS cord-304472-mi5v6512 22 36 100 100 CD cord-304472-mi5v6512 22 37 million million CD cord-304472-mi5v6512 22 38 cases case NNS cord-304472-mi5v6512 22 39 and and CC cord-304472-mi5v6512 22 40 the the DT cord-304472-mi5v6512 22 41 epidemic epidemic NN cord-304472-mi5v6512 22 42 trajectory trajectory NN cord-304472-mi5v6512 22 43 which which WDT cord-304472-mi5v6512 22 44 shows show VBZ cord-304472-mi5v6512 22 45 a a DT cord-304472-mi5v6512 22 46 relentless relentless JJ cord-304472-mi5v6512 22 47 increase increase NN cord-304472-mi5v6512 22 48 over over IN cord-304472-mi5v6512 22 49 the the DT cord-304472-mi5v6512 22 50 past past JJ cord-304472-mi5v6512 22 51 two two CD cord-304472-mi5v6512 22 52 decades decade NNS cord-304472-mi5v6512 22 53 [ [ -LRB- cord-304472-mi5v6512 22 54 2 2 CD cord-304472-mi5v6512 22 55 , , , cord-304472-mi5v6512 22 56 5,6 5,6 CD cord-304472-mi5v6512 22 57 ] ] -RRB- cord-304472-mi5v6512 22 58 . . . cord-304472-mi5v6512 23 1 Dengue dengue NN cord-304472-mi5v6512 23 2 infections infection NNS cord-304472-mi5v6512 23 3 in in IN cord-304472-mi5v6512 23 4 the the DT cord-304472-mi5v6512 23 5 communities community NNS cord-304472-mi5v6512 23 6 , , , cord-304472-mi5v6512 23 7 and and CC cord-304472-mi5v6512 23 8 even even RB cord-304472-mi5v6512 23 9 hospitalized hospitalize VBN cord-304472-mi5v6512 23 10 dengue dengue NN cord-304472-mi5v6512 23 11 , , , cord-304472-mi5v6512 23 12 lead lead VB cord-304472-mi5v6512 23 13 to to IN cord-304472-mi5v6512 23 14 inappropriate inappropriate JJ cord-304472-mi5v6512 23 15 antibiotic antibiotic JJ cord-304472-mi5v6512 23 16 use use NN cord-304472-mi5v6512 23 17 in in IN cord-304472-mi5v6512 23 18 more more JJR cord-304472-mi5v6512 23 19 than than IN cord-304472-mi5v6512 23 20 30%of 30%of JJ cord-304472-mi5v6512 23 21 cases case NNS cord-304472-mi5v6512 23 22 [ [ -LRB- cord-304472-mi5v6512 23 23 7 7 CD cord-304472-mi5v6512 23 24 ] ] -RRB- cord-304472-mi5v6512 23 25 . . . cord-304472-mi5v6512 24 1 Dengue dengue NN cord-304472-mi5v6512 24 2 has have VBZ cord-304472-mi5v6512 24 3 also also RB cord-304472-mi5v6512 24 4 become become VBN cord-304472-mi5v6512 24 5 a a DT cord-304472-mi5v6512 24 6 leading leading JJ cord-304472-mi5v6512 24 7 problem problem NN cord-304472-mi5v6512 24 8 in in IN cord-304472-mi5v6512 24 9 international international JJ cord-304472-mi5v6512 24 10 travelers traveler NNS cord-304472-mi5v6512 24 11 [ [ -LRB- cord-304472-mi5v6512 24 12 8 8 CD cord-304472-mi5v6512 24 13 ] ] -RRB- cord-304472-mi5v6512 24 14 [ [ -LRB- cord-304472-mi5v6512 24 15 9 9 CD cord-304472-mi5v6512 24 16 ] ] -RRB- cord-304472-mi5v6512 24 17 [ [ -LRB- cord-304472-mi5v6512 24 18 10 10 CD cord-304472-mi5v6512 24 19 ] ] -RRB- cord-304472-mi5v6512 24 20 [ [ -LRB- cord-304472-mi5v6512 24 21 11 11 CD cord-304472-mi5v6512 24 22 ] ] -RRB- cord-304472-mi5v6512 24 23 [ [ -LRB- cord-304472-mi5v6512 24 24 12 12 CD cord-304472-mi5v6512 24 25 ] ] -RRB- cord-304472-mi5v6512 24 26 . . . cord-304472-mi5v6512 25 1 Certain certain JJ cord-304472-mi5v6512 25 2 risk risk NN cord-304472-mi5v6512 25 3 factors factor NNS cord-304472-mi5v6512 25 4 are be VBP cord-304472-mi5v6512 25 5 predictive predictive JJ cord-304472-mi5v6512 25 6 of of IN cord-304472-mi5v6512 25 7 more more RBR cord-304472-mi5v6512 25 8 severe severe JJ cord-304472-mi5v6512 25 9 disease disease NN cord-304472-mi5v6512 25 10 outcome outcome NN cord-304472-mi5v6512 25 11 such such JJ cord-304472-mi5v6512 25 12 as as IN cord-304472-mi5v6512 25 13 young young JJ cord-304472-mi5v6512 25 14 or or CC cord-304472-mi5v6512 25 15 old old JJ cord-304472-mi5v6512 25 16 age age NN cord-304472-mi5v6512 25 17 , , , cord-304472-mi5v6512 25 18 prior prior JJ cord-304472-mi5v6512 25 19 dengue dengue NN cord-304472-mi5v6512 25 20 infection infection NN cord-304472-mi5v6512 25 21 , , , cord-304472-mi5v6512 25 22 diabetes diabetes NN cord-304472-mi5v6512 25 23 , , , cord-304472-mi5v6512 25 24 sickle sickle NN cord-304472-mi5v6512 25 25 cell cell NN cord-304472-mi5v6512 25 26 disease disease NN cord-304472-mi5v6512 25 27 and and CC cord-304472-mi5v6512 25 28 underlying underlying JJ cord-304472-mi5v6512 25 29 medical medical JJ cord-304472-mi5v6512 25 30 conditions condition NNS cord-304472-mi5v6512 25 31 [ [ -LRB- cord-304472-mi5v6512 25 32 2 2 CD cord-304472-mi5v6512 25 33 , , , cord-304472-mi5v6512 25 34 13 13 CD cord-304472-mi5v6512 25 35 ] ] -RRB- cord-304472-mi5v6512 25 36 . . . cord-304472-mi5v6512 26 1 All all DT cord-304472-mi5v6512 26 2 three three CD cord-304472-mi5v6512 26 3 leading lead VBG cord-304472-mi5v6512 26 4 dengue dengue NN cord-304472-mi5v6512 26 5 vaccine vaccine NN cord-304472-mi5v6512 26 6 candidates candidate NNS cord-304472-mi5v6512 26 7 are be VBP cord-304472-mi5v6512 26 8 liveattenuated liveattenuate VBN cord-304472-mi5v6512 26 9 vaccines vaccine NNS cord-304472-mi5v6512 26 10 , , , cord-304472-mi5v6512 26 11 with with IN cord-304472-mi5v6512 26 12 the the DT cord-304472-mi5v6512 26 13 main main JJ cord-304472-mi5v6512 26 14 difference difference NN cord-304472-mi5v6512 26 15 between between IN cord-304472-mi5v6512 26 16 them -PRON- PRP cord-304472-mi5v6512 26 17 being be VBG cord-304472-mi5v6512 26 18 the the DT cord-304472-mi5v6512 26 19 type type NN cord-304472-mi5v6512 26 20 of of IN cord-304472-mi5v6512 26 21 backbone backbone NN cord-304472-mi5v6512 26 22 and and CC cord-304472-mi5v6512 26 23 the the DT cord-304472-mi5v6512 26 24 extent extent NN cord-304472-mi5v6512 26 25 of of IN cord-304472-mi5v6512 26 26 chimerization chimerization NN cord-304472-mi5v6512 26 27 . . . cord-304472-mi5v6512 27 1 First first RB cord-304472-mi5v6512 27 2 licensed licensed JJ cord-304472-mi5v6512 27 3 dengue dengue NN cord-304472-mi5v6512 27 4 vaccine vaccine NN cord-304472-mi5v6512 27 5 CYD CYD NNP cord-304472-mi5v6512 27 6 - - HYPH cord-304472-mi5v6512 27 7 TDV TDV NNP cord-304472-mi5v6512 27 8 , , , cord-304472-mi5v6512 27 9 a a DT cord-304472-mi5v6512 27 10 tetravalent tetravalent NN cord-304472-mi5v6512 27 11 live live NN cord-304472-mi5v6512 27 12 attenuated attenuate VBN cord-304472-mi5v6512 27 13 with with IN cord-304472-mi5v6512 27 14 a a DT cord-304472-mi5v6512 27 15 yellow yellow JJ cord-304472-mi5v6512 27 16 fever fever NN cord-304472-mi5v6512 27 17 17D 17d CD cord-304472-mi5v6512 27 18 backbone backbone NN cord-304472-mi5v6512 27 19 , , , cord-304472-mi5v6512 27 20 is be VBZ cord-304472-mi5v6512 27 21 the the DT cord-304472-mi5v6512 27 22 first first JJ cord-304472-mi5v6512 27 23 dengue dengue NN cord-304472-mi5v6512 27 24 vaccine vaccine NN cord-304472-mi5v6512 27 25 to to TO cord-304472-mi5v6512 27 26 be be VB cord-304472-mi5v6512 27 27 licensed license VBN cord-304472-mi5v6512 27 28 , , , cord-304472-mi5v6512 27 29 under under IN cord-304472-mi5v6512 27 30 ' ' `` cord-304472-mi5v6512 27 31 Dengvaxia Dengvaxia NNP cord-304472-mi5v6512 27 32 ' ' '' cord-304472-mi5v6512 27 33 . . . cord-304472-mi5v6512 28 1 Despite despite IN cord-304472-mi5v6512 28 2 being be VBG cord-304472-mi5v6512 28 3 first first RB cord-304472-mi5v6512 28 4 licensed license VBN cord-304472-mi5v6512 28 5 in in IN cord-304472-mi5v6512 28 6 2015 2015 CD cord-304472-mi5v6512 28 7 in in IN cord-304472-mi5v6512 28 8 Mexico Mexico NNP cord-304472-mi5v6512 28 9 followed follow VBD cord-304472-mi5v6512 28 10 by by IN cord-304472-mi5v6512 28 11 20 20 CD cord-304472-mi5v6512 28 12 other other JJ cord-304472-mi5v6512 28 13 dengue dengue NN cord-304472-mi5v6512 28 14 endemic endemic JJ cord-304472-mi5v6512 28 15 countries country NNS cord-304472-mi5v6512 28 16 based base VBN cord-304472-mi5v6512 28 17 on on IN cord-304472-mi5v6512 28 18 results result NNS cord-304472-mi5v6512 28 19 from from IN cord-304472-mi5v6512 28 20 Phase phase NN cord-304472-mi5v6512 28 21 3 3 CD cord-304472-mi5v6512 28 22 trials trial NNS cord-304472-mi5v6512 28 23 conducted conduct VBN cord-304472-mi5v6512 28 24 in in IN cord-304472-mi5v6512 28 25 more more JJR cord-304472-mi5v6512 28 26 than than IN cord-304472-mi5v6512 28 27 30 30 CD cord-304472-mi5v6512 28 28 000 000 CD cord-304472-mi5v6512 28 29 children child NNS cord-304472-mi5v6512 28 30 and and CC cord-304472-mi5v6512 28 31 adolescents adolescent NNS cord-304472-mi5v6512 28 32 aged aged JJ cord-304472-mi5v6512 28 33 2À16 2à16 CD cord-304472-mi5v6512 28 34 , , , cord-304472-mi5v6512 28 35 it -PRON- PRP cord-304472-mi5v6512 28 36 was be VBD cord-304472-mi5v6512 28 37 only only RB cord-304472-mi5v6512 28 38 introduced introduce VBN cord-304472-mi5v6512 28 39 in in IN cord-304472-mi5v6512 28 40 two two CD cord-304472-mi5v6512 28 41 subnational subnational JJ cord-304472-mi5v6512 28 42 public public JJ cord-304472-mi5v6512 28 43 health health NN cord-304472-mi5v6512 28 44 programs program NNS cord-304472-mi5v6512 28 45 in in IN cord-304472-mi5v6512 28 46 the the DT cord-304472-mi5v6512 28 47 Philippines Philippines NNP cord-304472-mi5v6512 28 48 and and CC cord-304472-mi5v6512 28 49 Brazil Brazil NNP cord-304472-mi5v6512 28 50 . . . cord-304472-mi5v6512 29 1 The the DT cord-304472-mi5v6512 29 2 Phase phase NN cord-304472-mi5v6512 29 3 3 3 CD cord-304472-mi5v6512 29 4 trials trial NNS cord-304472-mi5v6512 29 5 revealed reveal VBD cord-304472-mi5v6512 29 6 a a DT cord-304472-mi5v6512 29 7 vaccine vaccine NN cord-304472-mi5v6512 29 8 efficacy efficacy NN cord-304472-mi5v6512 29 9 that that WDT cord-304472-mi5v6512 29 10 differed differ VBD cord-304472-mi5v6512 29 11 by by IN cord-304472-mi5v6512 29 12 age age NN cord-304472-mi5v6512 29 13 , , , cord-304472-mi5v6512 29 14 serostatus serostatus NN cord-304472-mi5v6512 29 15 and and CC cord-304472-mi5v6512 29 16 serotype serotype NN cord-304472-mi5v6512 29 17 . . . cord-304472-mi5v6512 30 1 In in IN cord-304472-mi5v6512 30 2 terms term NNS cord-304472-mi5v6512 30 3 of of IN cord-304472-mi5v6512 30 4 cumulative cumulative JJ cord-304472-mi5v6512 30 5 incidence incidence NN cord-304472-mi5v6512 30 6 , , , cord-304472-mi5v6512 30 7 CYD CYD NNP cord-304472-mi5v6512 30 8 - - HYPH cord-304472-mi5v6512 30 9 TDV TDV NNP cord-304472-mi5v6512 30 10 showed show VBD cord-304472-mi5v6512 30 11 a a DT cord-304472-mi5v6512 30 12 population population NN cord-304472-mi5v6512 30 13 level level NN cord-304472-mi5v6512 30 14 benefit benefit NN cord-304472-mi5v6512 30 15 [ [ -LRB- cord-304472-mi5v6512 30 16 14 14 CD cord-304472-mi5v6512 30 17 ] ] -RRB- cord-304472-mi5v6512 30 18 . . . cord-304472-mi5v6512 31 1 Further further JJ cord-304472-mi5v6512 31 2 post post VB cord-304472-mi5v6512 31 3 - - JJ cord-304472-mi5v6512 31 4 hoc hoc JJ cord-304472-mi5v6512 31 5 retrospective retrospective JJ cord-304472-mi5v6512 31 6 analyses analysis NNS cord-304472-mi5v6512 31 7 of of IN cord-304472-mi5v6512 31 8 the the DT cord-304472-mi5v6512 31 9 long long JJ cord-304472-mi5v6512 31 10 - - HYPH cord-304472-mi5v6512 31 11 term term NN cord-304472-mi5v6512 31 12 safety safety NN cord-304472-mi5v6512 31 13 data datum NNS cord-304472-mi5v6512 31 14 revealed reveal VBD cord-304472-mi5v6512 31 15 an an DT cord-304472-mi5v6512 31 16 excess excess JJ cord-304472-mi5v6512 31 17 risk risk NN cord-304472-mi5v6512 31 18 of of IN cord-304472-mi5v6512 31 19 severe severe JJ cord-304472-mi5v6512 31 20 dengue dengue NN cord-304472-mi5v6512 31 21 in in IN cord-304472-mi5v6512 31 22 those those DT cord-304472-mi5v6512 31 23 who who WP cord-304472-mi5v6512 31 24 were be VBD cord-304472-mi5v6512 31 25 seronegative seronegative JJ cord-304472-mi5v6512 31 26 at at IN cord-304472-mi5v6512 31 27 baseline baseline NN cord-304472-mi5v6512 31 28 . . . cord-304472-mi5v6512 32 1 Serostatus Serostatus NNP cord-304472-mi5v6512 32 2 refers refer VBZ cord-304472-mi5v6512 32 3 to to IN cord-304472-mi5v6512 32 4 whether whether IN cord-304472-mi5v6512 32 5 a a DT cord-304472-mi5v6512 32 6 person person NN cord-304472-mi5v6512 32 7 has have VBZ cord-304472-mi5v6512 32 8 had have VBN cord-304472-mi5v6512 32 9 dengue dengue NN cord-304472-mi5v6512 32 10 infections infection NNS cord-304472-mi5v6512 32 11 in in IN cord-304472-mi5v6512 32 12 the the DT cord-304472-mi5v6512 32 13 past past NN cord-304472-mi5v6512 32 14 [ [ -LRB- cord-304472-mi5v6512 32 15 15 15 CD cord-304472-mi5v6512 32 16 ] ] -RRB- cord-304472-mi5v6512 32 17 . . . cord-304472-mi5v6512 33 1 This this DT cord-304472-mi5v6512 33 2 increased increase VBN cord-304472-mi5v6512 33 3 risk risk NN cord-304472-mi5v6512 33 4 in in IN cord-304472-mi5v6512 33 5 seronegative seronegative JJ cord-304472-mi5v6512 33 6 subjects subject NNS cord-304472-mi5v6512 33 7 was be VBD cord-304472-mi5v6512 33 8 observed observe VBN cord-304472-mi5v6512 33 9 starting start VBG cord-304472-mi5v6512 33 10 from from IN cord-304472-mi5v6512 33 11 30 30 CD cord-304472-mi5v6512 33 12 months month NNS cord-304472-mi5v6512 33 13 after after IN cord-304472-mi5v6512 33 14 administration administration NN cord-304472-mi5v6512 33 15 of of IN cord-304472-mi5v6512 33 16 the the DT cord-304472-mi5v6512 33 17 first first JJ cord-304472-mi5v6512 33 18 dose dose NN cord-304472-mi5v6512 33 19 . . . cord-304472-mi5v6512 34 1 A a DT cord-304472-mi5v6512 34 2 plausible plausible JJ cord-304472-mi5v6512 34 3 hypothesis hypothesis NN cord-304472-mi5v6512 34 4 is be VBZ cord-304472-mi5v6512 34 5 that that DT cord-304472-mi5v6512 34 6 CYD CYD NNP cord-304472-mi5v6512 34 7 - - HYPH cord-304472-mi5v6512 34 8 TDV TDV NNP cord-304472-mi5v6512 34 9 may may MD cord-304472-mi5v6512 34 10 trigger trigger VB cord-304472-mi5v6512 34 11 an an DT cord-304472-mi5v6512 34 12 immune immune JJ cord-304472-mi5v6512 34 13 response response NN cord-304472-mi5v6512 34 14 to to IN cord-304472-mi5v6512 34 15 dengue dengue NN cord-304472-mi5v6512 34 16 in in IN cord-304472-mi5v6512 34 17 seronegative seronegative JJ cord-304472-mi5v6512 34 18 persons person NNS cord-304472-mi5v6512 34 19 that that WDT cord-304472-mi5v6512 34 20 predisposes predispose VBZ cord-304472-mi5v6512 34 21 them -PRON- PRP cord-304472-mi5v6512 34 22 to to IN cord-304472-mi5v6512 34 23 a a DT cord-304472-mi5v6512 34 24 higher high JJR cord-304472-mi5v6512 34 25 risk risk NN cord-304472-mi5v6512 34 26 of of IN cord-304472-mi5v6512 34 27 severe severe JJ cord-304472-mi5v6512 34 28 disease disease NN cord-304472-mi5v6512 34 29 , , , cord-304472-mi5v6512 34 30 analogue analogue JJ cord-304472-mi5v6512 34 31 to to IN cord-304472-mi5v6512 34 32 what what WP cord-304472-mi5v6512 34 33 is be VBZ cord-304472-mi5v6512 34 34 seen see VBN cord-304472-mi5v6512 34 35 in in IN cord-304472-mi5v6512 34 36 natural natural JJ cord-304472-mi5v6512 34 37 secondary secondary JJ cord-304472-mi5v6512 34 38 dengue dengue NN cord-304472-mi5v6512 34 39 infections infection NNS cord-304472-mi5v6512 34 40 [ [ -LRB- cord-304472-mi5v6512 34 41 16 16 CD cord-304472-mi5v6512 34 42 ] ] -RRB- cord-304472-mi5v6512 34 43 . . . cord-304472-mi5v6512 35 1 A a DT cord-304472-mi5v6512 35 2 subsequent subsequent JJ cord-304472-mi5v6512 35 3 infection infection NN cord-304472-mi5v6512 35 4 with with IN cord-304472-mi5v6512 35 5 the the DT cord-304472-mi5v6512 35 6 first first JJ cord-304472-mi5v6512 35 7 true true JJ cord-304472-mi5v6512 35 8 wild wild JJ cord-304472-mi5v6512 35 9 type type NN cord-304472-mi5v6512 35 10 dengue dengue NN cord-304472-mi5v6512 35 11 virus virus NN cord-304472-mi5v6512 35 12 would would MD cord-304472-mi5v6512 35 13 then then RB cord-304472-mi5v6512 35 14 be be VB cord-304472-mi5v6512 35 15 a a DT cord-304472-mi5v6512 35 16 ' ' `` cord-304472-mi5v6512 35 17 secondary secondary JJ cord-304472-mi5v6512 35 18 - - HYPH cord-304472-mi5v6512 35 19 like like JJ cord-304472-mi5v6512 35 20 ' ' '' cord-304472-mi5v6512 35 21 dengue dengue NN cord-304472-mi5v6512 35 22 illness illness NN cord-304472-mi5v6512 35 23 . . . cord-304472-mi5v6512 36 1 Dengue dengue NN cord-304472-mi5v6512 36 2 non non JJ cord-304472-mi5v6512 36 3 - - JJ cord-304472-mi5v6512 36 4 structural structural JJ cord-304472-mi5v6512 36 5 proteins protein NNS cord-304472-mi5v6512 36 6 ( ( -LRB- cord-304472-mi5v6512 36 7 NS NS NNP cord-304472-mi5v6512 36 8 ) ) -RRB- cord-304472-mi5v6512 36 9 are be VBP cord-304472-mi5v6512 36 10 absent absent JJ cord-304472-mi5v6512 36 11 from from IN cord-304472-mi5v6512 36 12 the the DT cord-304472-mi5v6512 36 13 Sanofi Sanofi NNP cord-304472-mi5v6512 36 14 dengue dengue NN cord-304472-mi5v6512 36 15 - - HYPH cord-304472-mi5v6512 36 16 yellow yellow JJ cord-304472-mi5v6512 36 17 fever fever NN cord-304472-mi5v6512 36 18 chimeric chimeric JJ cord-304472-mi5v6512 36 19 vaccine vaccine NN cord-304472-mi5v6512 36 20 . . . cord-304472-mi5v6512 37 1 Given give VBN cord-304472-mi5v6512 37 2 that that DT cord-304472-mi5v6512 37 3 NS1 ns1 NN cord-304472-mi5v6512 37 4 may may MD cord-304472-mi5v6512 37 5 have have VB cord-304472-mi5v6512 37 6 toxinlike toxinlike NN cord-304472-mi5v6512 37 7 properties property NNS cord-304472-mi5v6512 37 8 that that WDT cord-304472-mi5v6512 37 9 disrupt disrupt VBP cord-304472-mi5v6512 37 10 the the DT cord-304472-mi5v6512 37 11 endothelial endothelial JJ cord-304472-mi5v6512 37 12 glycocalyx glycocalyx NN cord-304472-mi5v6512 37 13 through through IN cord-304472-mi5v6512 37 14 either either CC cord-304472-mi5v6512 37 15 inflammatory inflammatory NN cord-304472-mi5v6512 37 16 - - HYPH cord-304472-mi5v6512 37 17 dependent dependent JJ cord-304472-mi5v6512 37 18 or or CC cord-304472-mi5v6512 37 19 independent independent JJ cord-304472-mi5v6512 37 20 pathways pathway NNS cord-304472-mi5v6512 37 21 [ [ -LRB- cord-304472-mi5v6512 37 22 17 17 CD cord-304472-mi5v6512 37 23 ] ] -RRB- cord-304472-mi5v6512 37 24 [ [ -LRB- cord-304472-mi5v6512 37 25 18 18 CD cord-304472-mi5v6512 37 26 ] ] -RRB- cord-304472-mi5v6512 37 27 [ [ -LRB- cord-304472-mi5v6512 37 28 19 19 CD cord-304472-mi5v6512 37 29 ] ] -RRB- cord-304472-mi5v6512 37 30 [ [ -LRB- cord-304472-mi5v6512 37 31 20 20 CD cord-304472-mi5v6512 37 32 ] ] -RRB- cord-304472-mi5v6512 37 33 , , , cord-304472-mi5v6512 37 34 the the DT cord-304472-mi5v6512 37 35 absence absence NN cord-304472-mi5v6512 37 36 of of IN cord-304472-mi5v6512 37 37 NS1 ns1 NN cord-304472-mi5v6512 37 38 in in IN cord-304472-mi5v6512 37 39 CYD CYD NNP cord-304472-mi5v6512 37 40 - - HYPH cord-304472-mi5v6512 37 41 TDV TDV NNP cord-304472-mi5v6512 37 42 could could MD cord-304472-mi5v6512 37 43 also also RB cord-304472-mi5v6512 37 44 be be VB cord-304472-mi5v6512 37 45 a a DT cord-304472-mi5v6512 37 46 potential potential JJ cord-304472-mi5v6512 37 47 explanation explanation NN cord-304472-mi5v6512 37 48 for for IN cord-304472-mi5v6512 37 49 the the DT cord-304472-mi5v6512 37 50 limited limited JJ cord-304472-mi5v6512 37 51 vaccine vaccine NN cord-304472-mi5v6512 37 52 performance performance NN cord-304472-mi5v6512 37 53 . . . cord-304472-mi5v6512 38 1 The the DT cord-304472-mi5v6512 38 2 World World NNP cord-304472-mi5v6512 38 3 Health Health NNP cord-304472-mi5v6512 38 4 Organization Organization NNP cord-304472-mi5v6512 38 5 ( ( -LRB- cord-304472-mi5v6512 38 6 WHO who WP cord-304472-mi5v6512 38 7 ) ) -RRB- cord-304472-mi5v6512 38 8 recommends recommend VBZ cord-304472-mi5v6512 38 9 that that IN cord-304472-mi5v6512 38 10 for for IN cord-304472-mi5v6512 38 11 countries country NNS cord-304472-mi5v6512 38 12 considering consider VBG cord-304472-mi5v6512 38 13 CYD CYD NNP cord-304472-mi5v6512 38 14 - - HYPH cord-304472-mi5v6512 38 15 TDV TDV NNP cord-304472-mi5v6512 38 16 vaccination vaccination NN cord-304472-mi5v6512 38 17 as as IN cord-304472-mi5v6512 38 18 part part NN cord-304472-mi5v6512 38 19 of of IN cord-304472-mi5v6512 38 20 their -PRON- PRP$ cord-304472-mi5v6512 38 21 dengue dengue NN cord-304472-mi5v6512 38 22 control control NN cord-304472-mi5v6512 38 23 program program NN cord-304472-mi5v6512 38 24 , , , cord-304472-mi5v6512 38 25 a a DT cord-304472-mi5v6512 38 26 pre pre JJ cord-304472-mi5v6512 38 27 - - JJ cord-304472-mi5v6512 38 28 vaccination vaccination JJ cord-304472-mi5v6512 38 29 screening screening NN cord-304472-mi5v6512 38 30 strategy strategy NN cord-304472-mi5v6512 38 31 , , , cord-304472-mi5v6512 38 32 in in IN cord-304472-mi5v6512 38 33 which which WDT cord-304472-mi5v6512 38 34 only only RB cord-304472-mi5v6512 38 35 dengue dengue NN cord-304472-mi5v6512 38 36 - - HYPH cord-304472-mi5v6512 38 37 seropositive seropositive JJ cord-304472-mi5v6512 38 38 persons person NNS cord-304472-mi5v6512 38 39 are be VBP cord-304472-mi5v6512 38 40 vaccinated vaccinate VBN cord-304472-mi5v6512 38 41 , , , cord-304472-mi5v6512 38 42 is be VBZ cord-304472-mi5v6512 38 43 the the DT cord-304472-mi5v6512 38 44 recommended recommend VBN cord-304472-mi5v6512 38 45 strategy strategy NN cord-304472-mi5v6512 38 46 [ [ -LRB- cord-304472-mi5v6512 38 47 21 21 CD cord-304472-mi5v6512 38 48 ] ] -RRB- cord-304472-mi5v6512 38 49 . . . cord-304472-mi5v6512 39 1 In in IN cord-304472-mi5v6512 39 2 May May NNP cord-304472-mi5v6512 39 3 2019 2019 CD cord-304472-mi5v6512 39 4 , , , cord-304472-mi5v6512 39 5 the the DT cord-304472-mi5v6512 39 6 US US NNP cord-304472-mi5v6512 39 7 Food Food NNP cord-304472-mi5v6512 39 8 and and CC cord-304472-mi5v6512 39 9 Drug Drug NNP cord-304472-mi5v6512 39 10 Administration Administration NNP cord-304472-mi5v6512 39 11 ( ( -LRB- cord-304472-mi5v6512 39 12 FDA FDA NNP cord-304472-mi5v6512 39 13 ) ) -RRB- cord-304472-mi5v6512 39 14 approved approve VBD cord-304472-mi5v6512 39 15 CYD CYD NNP cord-304472-mi5v6512 39 16 - - HYPH cord-304472-mi5v6512 39 17 TDV TDV NNP cord-304472-mi5v6512 39 18 for for IN cord-304472-mi5v6512 39 19 use use NN cord-304472-mi5v6512 39 20 in in IN cord-304472-mi5v6512 39 21 seropositive seropositive JJ cord-304472-mi5v6512 39 22 individuals individual NNS cord-304472-mi5v6512 39 23 9 9 CD cord-304472-mi5v6512 39 24 through through IN cord-304472-mi5v6512 39 25 16 16 CD cord-304472-mi5v6512 39 26 years year NNS cord-304472-mi5v6512 39 27 of of IN cord-304472-mi5v6512 39 28 age age NN cord-304472-mi5v6512 39 29 living live VBG cord-304472-mi5v6512 39 30 in in IN cord-304472-mi5v6512 39 31 endemic endemic JJ cord-304472-mi5v6512 39 32 areas area NNS cord-304472-mi5v6512 39 33 of of IN cord-304472-mi5v6512 39 34 the the DT cord-304472-mi5v6512 39 35 U.S. U.S. NNP cord-304472-mi5v6512 40 1 The the DT cord-304472-mi5v6512 40 2 European European NNP cord-304472-mi5v6512 40 3 Medicine Medicine NNP cord-304472-mi5v6512 40 4 agency agency NN cord-304472-mi5v6512 40 5 also also RB cord-304472-mi5v6512 40 6 endorsed endorse VBD cord-304472-mi5v6512 40 7 the the DT cord-304472-mi5v6512 40 8 use use NN cord-304472-mi5v6512 40 9 of of IN cord-304472-mi5v6512 40 10 this this DT cord-304472-mi5v6512 40 11 vaccine vaccine NN cord-304472-mi5v6512 40 12 in in IN cord-304472-mi5v6512 40 13 seropositive seropositive JJ cord-304472-mi5v6512 40 14 individuals individual NNS cord-304472-mi5v6512 40 15 with with IN cord-304472-mi5v6512 40 16 a a DT cord-304472-mi5v6512 40 17 wider wide JJR cord-304472-mi5v6512 40 18 age age NN cord-304472-mi5v6512 40 19 range range NN cord-304472-mi5v6512 40 20 . . . cord-304472-mi5v6512 41 1 The the DT cord-304472-mi5v6512 41 2 programmatic programmatic JJ cord-304472-mi5v6512 41 3 use use NN cord-304472-mi5v6512 41 4 of of IN cord-304472-mi5v6512 41 5 CYD CYD NNP cord-304472-mi5v6512 41 6 - - HYPH cord-304472-mi5v6512 41 7 TDV TDV NNP cord-304472-mi5v6512 41 8 , , , cord-304472-mi5v6512 41 9 therefore therefore RB cord-304472-mi5v6512 41 10 , , , cord-304472-mi5v6512 41 11 requires require VBZ cord-304472-mi5v6512 41 12 screening screening NN cord-304472-mi5v6512 41 13 for for IN cord-304472-mi5v6512 41 14 serostatus serostatus NN cord-304472-mi5v6512 41 15 before before IN cord-304472-mi5v6512 41 16 vaccination vaccination NN cord-304472-mi5v6512 41 17 . . . cord-304472-mi5v6512 42 1 IgG IgG NNP cord-304472-mi5v6512 42 2 - - HYPH cord-304472-mi5v6512 42 3 based base VBN cord-304472-mi5v6512 42 4 enzyme enzyme NN cord-304472-mi5v6512 42 5 - - HYPH cord-304472-mi5v6512 42 6 linked link VBN cord-304472-mi5v6512 42 7 immunosorbent immunosorbent JJ cord-304472-mi5v6512 42 8 assays assay NNS cord-304472-mi5v6512 42 9 ( ( -LRB- cord-304472-mi5v6512 42 10 ELISAs elisa NNS cord-304472-mi5v6512 42 11 ) ) -RRB- cord-304472-mi5v6512 42 12 or or CC cord-304472-mi5v6512 42 13 rapid rapid JJ cord-304472-mi5v6512 42 14 diagnostic diagnostic JJ cord-304472-mi5v6512 42 15 tests test NNS cord-304472-mi5v6512 42 16 ( ( -LRB- cord-304472-mi5v6512 42 17 RDTs RDTs NNP cord-304472-mi5v6512 42 18 ) ) -RRB- cord-304472-mi5v6512 42 19 can can MD cord-304472-mi5v6512 42 20 be be VB cord-304472-mi5v6512 42 21 used use VBN cord-304472-mi5v6512 42 22 for for IN cord-304472-mi5v6512 42 23 pre pre JJ cord-304472-mi5v6512 42 24 - - JJ cord-304472-mi5v6512 42 25 vaccination vaccination JJ cord-304472-mi5v6512 42 26 screening screening NN cord-304472-mi5v6512 42 27 , , , cord-304472-mi5v6512 42 28 also also RB cord-304472-mi5v6512 42 29 called call VBD cord-304472-mi5v6512 42 30 a a DT cord-304472-mi5v6512 42 31 ' ' `` cord-304472-mi5v6512 42 32 test test NN cord-304472-mi5v6512 42 33 and and CC cord-304472-mi5v6512 42 34 vaccinate vaccinate VB cord-304472-mi5v6512 42 35 ' ' '' cord-304472-mi5v6512 42 36 strategy strategy NN cord-304472-mi5v6512 42 37 . . . cord-304472-mi5v6512 43 1 Ideally ideally RB cord-304472-mi5v6512 43 2 , , , cord-304472-mi5v6512 43 3 a a DT cord-304472-mi5v6512 43 4 screening screening NN cord-304472-mi5v6512 43 5 test test NN cord-304472-mi5v6512 43 6 should should MD cord-304472-mi5v6512 43 7 be be VB cord-304472-mi5v6512 43 8 both both CC cord-304472-mi5v6512 43 9 highly highly RB cord-304472-mi5v6512 43 10 sensitive sensitive JJ cord-304472-mi5v6512 43 11 and and CC cord-304472-mi5v6512 43 12 specific specific JJ cord-304472-mi5v6512 43 13 to to TO cord-304472-mi5v6512 43 14 minimize minimize VB cord-304472-mi5v6512 43 15 false false JJ cord-304472-mi5v6512 43 16 positives positive NNS cord-304472-mi5v6512 43 17 and and CC cord-304472-mi5v6512 43 18 negatives negative NNS cord-304472-mi5v6512 43 19 to to TO cord-304472-mi5v6512 43 20 yield yield VB cord-304472-mi5v6512 43 21 maximal maximal JJ cord-304472-mi5v6512 43 22 population population NN cord-304472-mi5v6512 43 23 level level NN cord-304472-mi5v6512 43 24 benefit benefit NN cord-304472-mi5v6512 43 25 and and CC cord-304472-mi5v6512 43 26 minimize minimize VB cord-304472-mi5v6512 43 27 harm harm NN cord-304472-mi5v6512 43 28 by by IN cord-304472-mi5v6512 43 29 correctly correctly RB cord-304472-mi5v6512 43 30 screening screen VBG cord-304472-mi5v6512 43 31 for for IN cord-304472-mi5v6512 43 32 seropositive seropositive JJ cord-304472-mi5v6512 43 33 individuals individual NNS cord-304472-mi5v6512 43 34 only only RB cord-304472-mi5v6512 43 35 [ [ -LRB- cord-304472-mi5v6512 43 36 22 22 CD cord-304472-mi5v6512 43 37 ] ] -RRB- cord-304472-mi5v6512 43 38 . . . cord-304472-mi5v6512 44 1 It -PRON- PRP cord-304472-mi5v6512 44 2 should should MD cord-304472-mi5v6512 44 3 also also RB cord-304472-mi5v6512 44 4 be be VB cord-304472-mi5v6512 44 5 affordable affordable JJ cord-304472-mi5v6512 44 6 , , , cord-304472-mi5v6512 44 7 simple simple JJ cord-304472-mi5v6512 44 8 to to TO cord-304472-mi5v6512 44 9 use use VB cord-304472-mi5v6512 44 10 and and CC cord-304472-mi5v6512 44 11 provide provide VB cord-304472-mi5v6512 44 12 rapid rapid JJ cord-304472-mi5v6512 44 13 results result NNS cord-304472-mi5v6512 44 14 . . . cord-304472-mi5v6512 45 1 Two two CD cord-304472-mi5v6512 45 2 recent recent JJ cord-304472-mi5v6512 45 3 comparative comparative JJ cord-304472-mi5v6512 45 4 evaluations evaluation NNS cord-304472-mi5v6512 45 5 on on IN cord-304472-mi5v6512 45 6 currently currently RB cord-304472-mi5v6512 45 7 available available JJ cord-304472-mi5v6512 45 8 assays assay NNS cord-304472-mi5v6512 45 9 showed show VBD cord-304472-mi5v6512 45 10 high high JJ cord-304472-mi5v6512 45 11 specificity specificity NN cord-304472-mi5v6512 45 12 ( ( -LRB- cord-304472-mi5v6512 45 13 > > NFP cord-304472-mi5v6512 45 14 98 98 CD cord-304472-mi5v6512 45 15 % % NN cord-304472-mi5v6512 45 16 ) ) -RRB- cord-304472-mi5v6512 45 17 for for IN cord-304472-mi5v6512 45 18 all all DT cord-304472-mi5v6512 45 19 immunoassays immunoassay NNS cord-304472-mi5v6512 45 20 apart apart RB cord-304472-mi5v6512 45 21 from from IN cord-304472-mi5v6512 45 22 one one CD cord-304472-mi5v6512 45 23 RDT RDT NNP cord-304472-mi5v6512 45 24 , , , cord-304472-mi5v6512 45 25 but but CC cord-304472-mi5v6512 45 26 variable variable JJ cord-304472-mi5v6512 45 27 sensitivities sensitivity NNS cord-304472-mi5v6512 45 28 ( ( -LRB- cord-304472-mi5v6512 45 29 higher high JJR cord-304472-mi5v6512 45 30 sensitivities sensitivity NNS cord-304472-mi5v6512 45 31 observed observe VBN cord-304472-mi5v6512 45 32 for for IN cord-304472-mi5v6512 45 33 the the DT cord-304472-mi5v6512 45 34 ELISAs elisa NNS cord-304472-mi5v6512 45 35 [ [ -LRB- cord-304472-mi5v6512 45 36 89 89 CD cord-304472-mi5v6512 45 37 % % NN cord-304472-mi5v6512 45 38 and and CC cord-304472-mi5v6512 45 39 93 93 CD cord-304472-mi5v6512 45 40 % % NN cord-304472-mi5v6512 45 41 ] ] -RRB- cord-304472-mi5v6512 45 42 than than IN cord-304472-mi5v6512 45 43 the the DT cord-304472-mi5v6512 45 44 RDTs rdt NNS cord-304472-mi5v6512 45 45 [ [ -LRB- cord-304472-mi5v6512 45 46 48 48 CD cord-304472-mi5v6512 45 47 - - SYM cord-304472-mi5v6512 45 48 71 71 CD cord-304472-mi5v6512 45 49 % % NN cord-304472-mi5v6512 45 50 ] ] -RRB- cord-304472-mi5v6512 45 51 ) ) -RRB- cord-304472-mi5v6512 45 52 [ [ -LRB- cord-304472-mi5v6512 45 53 23 23 CD cord-304472-mi5v6512 45 54 , , , cord-304472-mi5v6512 45 55 24 24 CD cord-304472-mi5v6512 45 56 ] ] -RRB- cord-304472-mi5v6512 45 57 Sensitivity sensitivity NN cord-304472-mi5v6512 45 58 appeared appear VBD cord-304472-mi5v6512 45 59 similar similar JJ cord-304472-mi5v6512 45 60 in in IN cord-304472-mi5v6512 45 61 samples sample NNS cord-304472-mi5v6512 45 62 from from IN cord-304472-mi5v6512 45 63 individuals individual NNS cord-304472-mi5v6512 45 64 with with IN cord-304472-mi5v6512 45 65 recent recent JJ cord-304472-mi5v6512 45 66 and and CC cord-304472-mi5v6512 45 67 remote remote JJ cord-304472-mi5v6512 45 68 virologically virologically NN cord-304472-mi5v6512 45 69 confirmed confirm VBD cord-304472-mi5v6512 45 70 dengue dengue NN cord-304472-mi5v6512 45 71 ( ( -LRB- cord-304472-mi5v6512 45 72 VCD VCD NNP cord-304472-mi5v6512 45 73 ) ) -RRB- cord-304472-mi5v6512 45 74 . . . cord-304472-mi5v6512 46 1 Cross cross NN cord-304472-mi5v6512 46 2 - - NN cord-304472-mi5v6512 46 3 reactivity reactivity NN cord-304472-mi5v6512 46 4 to to IN cord-304472-mi5v6512 46 5 other other JJ cord-304472-mi5v6512 46 6 flaviviruses flavivirus NNS cord-304472-mi5v6512 46 7 was be VBD cord-304472-mi5v6512 46 8 low low JJ cord-304472-mi5v6512 46 9 with with IN cord-304472-mi5v6512 46 10 RDTs rdt NNS cord-304472-mi5v6512 46 11 ( ( -LRB- cord-304472-mi5v6512 46 12 < < XX cord-304472-mi5v6512 46 13 / / SYM cord-304472-mi5v6512 46 14 = = SYM cord-304472-mi5v6512 46 15 7 7 CD cord-304472-mi5v6512 46 16 % % NN cord-304472-mi5v6512 46 17 ) ) -RRB- cord-304472-mi5v6512 46 18 , , , cord-304472-mi5v6512 46 19 but but CC cord-304472-mi5v6512 46 20 more more RBR cord-304472-mi5v6512 46 21 significant significant JJ cord-304472-mi5v6512 46 22 with with IN cord-304472-mi5v6512 46 23 ELISAs elisa NNS cord-304472-mi5v6512 46 24 ( ( -LRB- cord-304472-mi5v6512 46 25 up up IN cord-304472-mi5v6512 46 26 to to TO cord-304472-mi5v6512 46 27 51 51 CD cord-304472-mi5v6512 46 28 % % NN cord-304472-mi5v6512 46 29 for for IN cord-304472-mi5v6512 46 30 West West NNP cord-304472-mi5v6512 46 31 Nile Nile NNP cord-304472-mi5v6512 46 32 and and CC cord-304472-mi5v6512 46 33 34 34 CD cord-304472-mi5v6512 46 34 % % NN cord-304472-mi5v6512 46 35 for for IN cord-304472-mi5v6512 46 36 Zika Zika NNP cord-304472-mi5v6512 46 37 ) ) -RRB- cord-304472-mi5v6512 46 38 . . . cord-304472-mi5v6512 47 1 CYD CYD NNP cord-304472-mi5v6512 47 2 - - HYPH cord-304472-mi5v6512 47 3 TDV TDV NNP cord-304472-mi5v6512 47 4 's 's POS cord-304472-mi5v6512 47 5 public public JJ cord-304472-mi5v6512 47 6 health health NN cord-304472-mi5v6512 47 7 utility utility NN cord-304472-mi5v6512 47 8 is be VBZ cord-304472-mi5v6512 47 9 limited limit VBN cord-304472-mi5v6512 47 10 to to IN cord-304472-mi5v6512 47 11 seropositive seropositive JJ cord-304472-mi5v6512 47 12 persons person NNS cord-304472-mi5v6512 47 13 . . . cord-304472-mi5v6512 48 1 Implementation implementation NN cord-304472-mi5v6512 48 2 research research NN cord-304472-mi5v6512 48 3 is be VBZ cord-304472-mi5v6512 48 4 now now RB cord-304472-mi5v6512 48 5 needed need VBN cord-304472-mi5v6512 48 6 on on IN cord-304472-mi5v6512 48 7 how how WRB cord-304472-mi5v6512 48 8 and and CC cord-304472-mi5v6512 48 9 for for IN cord-304472-mi5v6512 48 10 which which WDT cord-304472-mi5v6512 48 11 settings setting NNS cord-304472-mi5v6512 48 12 ( ( -LRB- cord-304472-mi5v6512 48 13 e.g. e.g. IN cord-304472-mi5v6512 48 14 school school NN cord-304472-mi5v6512 48 15 settings setting NNS cord-304472-mi5v6512 48 16 ) ) -RRB- cord-304472-mi5v6512 48 17 a a DT cord-304472-mi5v6512 48 18 prevaccination prevaccination NN cord-304472-mi5v6512 48 19 screening screening NN cord-304472-mi5v6512 48 20 can can MD cord-304472-mi5v6512 48 21 be be VB cord-304472-mi5v6512 48 22 rolled roll VBN cord-304472-mi5v6512 48 23 out out RP cord-304472-mi5v6512 48 24 for for IN cord-304472-mi5v6512 48 25 programmatic programmatic JJ cord-304472-mi5v6512 48 26 national national JJ cord-304472-mi5v6512 48 27 or or CC cord-304472-mi5v6512 48 28 subnational subnational JJ cord-304472-mi5v6512 48 29 use use NN cord-304472-mi5v6512 48 30 [ [ -LRB- cord-304472-mi5v6512 48 31 25 25 CD cord-304472-mi5v6512 48 32 ] ] -RRB- cord-304472-mi5v6512 48 33 . . . cord-304472-mi5v6512 49 1 In in IN cord-304472-mi5v6512 49 2 private private JJ cord-304472-mi5v6512 49 3 clinics clinic NNS cord-304472-mi5v6512 49 4 and and CC cord-304472-mi5v6512 49 5 travel travel NN cord-304472-mi5v6512 49 6 medicine medicine NN cord-304472-mi5v6512 49 7 settings setting NNS cord-304472-mi5v6512 49 8 [ [ -LRB- cord-304472-mi5v6512 49 9 26 26 CD cord-304472-mi5v6512 49 10 ] ] -RRB- cord-304472-mi5v6512 49 11 , , , cord-304472-mi5v6512 49 12 blood blood NN cord-304472-mi5v6512 49 13 is be VBZ cord-304472-mi5v6512 49 14 often often RB cord-304472-mi5v6512 49 15 taken take VBN cord-304472-mi5v6512 49 16 before before IN cord-304472-mi5v6512 49 17 hepatitis hepatitis NN cord-304472-mi5v6512 49 18 B B NNP cord-304472-mi5v6512 49 19 vaccination vaccination NN cord-304472-mi5v6512 49 20 to to TO cord-304472-mi5v6512 49 21 check check VB cord-304472-mi5v6512 49 22 for for IN cord-304472-mi5v6512 49 23 hepatitis hepatitis NN cord-304472-mi5v6512 49 24 B B NNP cord-304472-mi5v6512 49 25 serostatus serostatus NN cord-304472-mi5v6512 49 26 and and CC cord-304472-mi5v6512 49 27 other other JJ cord-304472-mi5v6512 49 28 vaccine vaccine NN cord-304472-mi5v6512 49 29 - - HYPH cord-304472-mi5v6512 49 30 preventable preventable JJ cord-304472-mi5v6512 49 31 diseases disease NNS cord-304472-mi5v6512 49 32 ; ; : cord-304472-mi5v6512 49 33 thus thus RB cord-304472-mi5v6512 49 34 there there EX cord-304472-mi5v6512 49 35 is be VBZ cord-304472-mi5v6512 49 36 precedence precedence NN cord-304472-mi5v6512 49 37 for for IN cord-304472-mi5v6512 49 38 pre pre JJ cord-304472-mi5v6512 49 39 - - JJ cord-304472-mi5v6512 49 40 vaccination vaccination JJ cord-304472-mi5v6512 49 41 screening screening NN cord-304472-mi5v6512 49 42 . . . cord-304472-mi5v6512 50 1 Research research NN cord-304472-mi5v6512 50 2 is be VBZ cord-304472-mi5v6512 50 3 also also RB cord-304472-mi5v6512 50 4 needed need VBN cord-304472-mi5v6512 50 5 to to TO cord-304472-mi5v6512 50 6 evaluate evaluate VB cord-304472-mi5v6512 50 7 vaccine vaccine NN cord-304472-mi5v6512 50 8 schedules schedule NNS cord-304472-mi5v6512 50 9 with with IN cord-304472-mi5v6512 50 10 fewer few JJR cord-304472-mi5v6512 50 11 doses dose NNS cord-304472-mi5v6512 50 12 , , , cord-304472-mi5v6512 50 13 assess assess VB cord-304472-mi5v6512 50 14 the the DT cord-304472-mi5v6512 50 15 need need NN cord-304472-mi5v6512 50 16 and and CC cord-304472-mi5v6512 50 17 timing timing NN cord-304472-mi5v6512 50 18 for for IN cord-304472-mi5v6512 50 19 booster booster NN cord-304472-mi5v6512 50 20 doses dose NNS cord-304472-mi5v6512 50 21 , , , cord-304472-mi5v6512 50 22 and and CC cord-304472-mi5v6512 50 23 identify identify VB cord-304472-mi5v6512 50 24 populations population NNS cord-304472-mi5v6512 50 25 that that WDT cord-304472-mi5v6512 50 26 will will MD cord-304472-mi5v6512 50 27 benefit benefit VB cord-304472-mi5v6512 50 28 most most JJS cord-304472-mi5v6512 50 29 from from IN cord-304472-mi5v6512 50 30 this this DT cord-304472-mi5v6512 50 31 vaccine vaccine NN cord-304472-mi5v6512 50 32 [ [ -LRB- cord-304472-mi5v6512 50 33 21 21 CD cord-304472-mi5v6512 50 34 , , , cord-304472-mi5v6512 50 35 27 27 CD cord-304472-mi5v6512 50 36 , , , cord-304472-mi5v6512 50 37 28 28 CD cord-304472-mi5v6512 50 38 ] ] -RRB- cord-304472-mi5v6512 50 39 . . . cord-304472-mi5v6512 51 1 Lessons lesson NNS cord-304472-mi5v6512 51 2 from from IN cord-304472-mi5v6512 51 3 the the DT cord-304472-mi5v6512 51 4 first first JJ cord-304472-mi5v6512 51 5 licensed licensed JJ cord-304472-mi5v6512 51 6 dengue dengue NN cord-304472-mi5v6512 51 7 vaccine vaccine NN cord-304472-mi5v6512 51 8 for for IN cord-304472-mi5v6512 51 9 clinical clinical JJ cord-304472-mi5v6512 51 10 trial trial NN cord-304472-mi5v6512 51 11 designs design NNS cord-304472-mi5v6512 52 1 Lessons lesson NNS cord-304472-mi5v6512 52 2 from from IN cord-304472-mi5v6512 52 3 the the DT cord-304472-mi5v6512 52 4 first first JJ cord-304472-mi5v6512 52 5 dengue dengue NN cord-304472-mi5v6512 52 6 vaccine vaccine NN cord-304472-mi5v6512 52 7 have have VBP cord-304472-mi5v6512 52 8 shaped shape VBN cord-304472-mi5v6512 52 9 how how WRB cord-304472-mi5v6512 52 10 second second JJ cord-304472-mi5v6512 52 11 - - HYPH cord-304472-mi5v6512 52 12 generation generation NN cord-304472-mi5v6512 52 13 dengue dengue NN cord-304472-mi5v6512 52 14 vaccines vaccine NNS cord-304472-mi5v6512 52 15 should should MD cord-304472-mi5v6512 52 16 be be VB cord-304472-mi5v6512 52 17 evaluated evaluate VBN cord-304472-mi5v6512 52 18 . . . cord-304472-mi5v6512 53 1 The the DT cord-304472-mi5v6512 53 2 effect effect NN cord-304472-mi5v6512 53 3 on on IN cord-304472-mi5v6512 53 4 cellular cellular JJ cord-304472-mi5v6512 53 5 immunity immunity NN cord-304472-mi5v6512 53 6 needs need VBZ cord-304472-mi5v6512 53 7 to to TO cord-304472-mi5v6512 53 8 be be VB cord-304472-mi5v6512 53 9 studied study VBN cord-304472-mi5v6512 53 10 , , , cord-304472-mi5v6512 53 11 including include VBG cord-304472-mi5v6512 53 12 the the DT cord-304472-mi5v6512 53 13 extent extent NN cord-304472-mi5v6512 53 14 of of IN cord-304472-mi5v6512 53 15 truly truly RB cord-304472-mi5v6512 53 16 neutralizing neutralize VBG cord-304472-mi5v6512 53 17 antibodies antibody NNS cord-304472-mi5v6512 53 18 versus versus IN cord-304472-mi5v6512 53 19 just just RB cord-304472-mi5v6512 53 20 transient transient JJ cord-304472-mi5v6512 53 21 cross cross JJ cord-304472-mi5v6512 53 22 - - JJ cord-304472-mi5v6512 53 23 protective protective JJ cord-304472-mi5v6512 53 24 antibodies antibody NNS cord-304472-mi5v6512 53 25 . . . cord-304472-mi5v6512 54 1 Vaccine vaccine NN cord-304472-mi5v6512 54 2 trial trial NN cord-304472-mi5v6512 54 3 designs design NNS cord-304472-mi5v6512 54 4 should should MD cord-304472-mi5v6512 54 5 account account VB cord-304472-mi5v6512 54 6 for for IN cord-304472-mi5v6512 54 7 the the DT cord-304472-mi5v6512 54 8 known known JJ cord-304472-mi5v6512 54 9 period period NN cord-304472-mi5v6512 54 10 of of IN cord-304472-mi5v6512 54 11 crossprotection crossprotection NN cord-304472-mi5v6512 54 12 between between IN cord-304472-mi5v6512 54 13 serotypes serotype NNS cord-304472-mi5v6512 54 14 which which WDT cord-304472-mi5v6512 54 15 can can MD cord-304472-mi5v6512 54 16 last last VB cord-304472-mi5v6512 54 17 up up IN cord-304472-mi5v6512 54 18 to to IN cord-304472-mi5v6512 54 19 one one CD cord-304472-mi5v6512 54 20 even even RB cord-304472-mi5v6512 54 21 two two CD cord-304472-mi5v6512 54 22 years year NNS cord-304472-mi5v6512 54 23 before before IN cord-304472-mi5v6512 54 24 safety safety NN cord-304472-mi5v6512 54 25 signals signal NNS cord-304472-mi5v6512 54 26 may may MD cord-304472-mi5v6512 54 27 appear appear VB cord-304472-mi5v6512 54 28 in in IN cord-304472-mi5v6512 54 29 year year NN cord-304472-mi5v6512 54 30 3 3 CD cord-304472-mi5v6512 54 31 and and CC cord-304472-mi5v6512 54 32 beyond beyond IN cord-304472-mi5v6512 54 33 . . . cord-304472-mi5v6512 55 1 Trial trial NN cord-304472-mi5v6512 55 2 designs design NNS cord-304472-mi5v6512 55 3 , , , cord-304472-mi5v6512 55 4 therefore therefore RB cord-304472-mi5v6512 55 5 , , , cord-304472-mi5v6512 55 6 need need VBP cord-304472-mi5v6512 55 7 to to TO cord-304472-mi5v6512 55 8 be be VB cord-304472-mi5v6512 55 9 extended extend VBN cord-304472-mi5v6512 55 10 to to TO cord-304472-mi5v6512 55 11 include include VB cord-304472-mi5v6512 55 12 active active JJ cord-304472-mi5v6512 55 13 surveillance surveillance NN cord-304472-mi5v6512 55 14 of of IN cord-304472-mi5v6512 55 15 trial trial NN cord-304472-mi5v6512 55 16 participants participant NNS cord-304472-mi5v6512 55 17 up up IN cord-304472-mi5v6512 55 18 to to IN cord-304472-mi5v6512 55 19 3À5 3à5 CD cord-304472-mi5v6512 55 20 years year NNS cord-304472-mi5v6512 55 21 [ [ -LRB- cord-304472-mi5v6512 55 22 29 29 CD cord-304472-mi5v6512 55 23 ] ] -RRB- cord-304472-mi5v6512 55 24 . . . cord-304472-mi5v6512 56 1 Furthermore furthermore RB cord-304472-mi5v6512 56 2 , , , cord-304472-mi5v6512 56 3 vaccine vaccine NN cord-304472-mi5v6512 56 4 evaluation evaluation NN cord-304472-mi5v6512 56 5 must must MD cord-304472-mi5v6512 56 6 include include VB cord-304472-mi5v6512 56 7 a a DT cord-304472-mi5v6512 56 8 - - HYPH cord-304472-mi5v6512 56 9 priori priori FW cord-304472-mi5v6512 56 10 analysis analysis NN cord-304472-mi5v6512 56 11 plans plan NNS cord-304472-mi5v6512 56 12 for for IN cord-304472-mi5v6512 56 13 stratification stratification NN cord-304472-mi5v6512 56 14 by by IN cord-304472-mi5v6512 56 15 serostatus serostatus NN cord-304472-mi5v6512 56 16 and and CC cord-304472-mi5v6512 56 17 serotype serotype NN cord-304472-mi5v6512 56 18 . . . cord-304472-mi5v6512 57 1 To to TO cord-304472-mi5v6512 57 2 stratify stratify VB cord-304472-mi5v6512 57 3 by by IN cord-304472-mi5v6512 57 4 serostatus serostatus NN cord-304472-mi5v6512 57 5 , , , cord-304472-mi5v6512 57 6 baseline baseline JJ cord-304472-mi5v6512 57 7 blood blood NN cord-304472-mi5v6512 57 8 samples sample NNS cord-304472-mi5v6512 57 9 need need VBP cord-304472-mi5v6512 57 10 to to TO cord-304472-mi5v6512 57 11 be be VB cord-304472-mi5v6512 57 12 taken take VBN cord-304472-mi5v6512 57 13 from from IN cord-304472-mi5v6512 57 14 all all DT cord-304472-mi5v6512 57 15 study study NN cord-304472-mi5v6512 57 16 subjects subject NNS cord-304472-mi5v6512 57 17 . . . cord-304472-mi5v6512 58 1 When when WRB cord-304472-mi5v6512 58 2 interpreting interpret VBG cord-304472-mi5v6512 58 3 efficacy efficacy NN cord-304472-mi5v6512 58 4 results result NNS cord-304472-mi5v6512 58 5 , , , cord-304472-mi5v6512 58 6 one one PRP cord-304472-mi5v6512 58 7 has have VBZ cord-304472-mi5v6512 58 8 to to TO cord-304472-mi5v6512 58 9 consider consider VB cord-304472-mi5v6512 58 10 the the DT cord-304472-mi5v6512 58 11 predominance predominance NN cord-304472-mi5v6512 58 12 of of IN cord-304472-mi5v6512 58 13 a a DT cord-304472-mi5v6512 58 14 given give VBN cord-304472-mi5v6512 58 15 serotype serotype NN cord-304472-mi5v6512 58 16 and and CC cord-304472-mi5v6512 58 17 the the DT cord-304472-mi5v6512 58 18 proportion proportion NN cord-304472-mi5v6512 58 19 of of IN cord-304472-mi5v6512 58 20 individuals individual NNS cord-304472-mi5v6512 58 21 who who WP cord-304472-mi5v6512 58 22 are be VBP cord-304472-mi5v6512 58 23 seronegative seronegative JJ cord-304472-mi5v6512 58 24 in in IN cord-304472-mi5v6512 58 25 a a DT cord-304472-mi5v6512 58 26 population population NN cord-304472-mi5v6512 58 27 , , , cord-304472-mi5v6512 58 28 which which WDT cord-304472-mi5v6512 58 29 can can MD cord-304472-mi5v6512 58 30 vary vary VB cord-304472-mi5v6512 58 31 from from IN cord-304472-mi5v6512 58 32 year year NN cord-304472-mi5v6512 58 33 to to IN cord-304472-mi5v6512 58 34 year year NN cord-304472-mi5v6512 58 35 and and CC cord-304472-mi5v6512 58 36 country country NN cord-304472-mi5v6512 58 37 to to IN cord-304472-mi5v6512 58 38 country country NN cord-304472-mi5v6512 58 39 [ [ -LRB- cord-304472-mi5v6512 58 40 30 30 CD cord-304472-mi5v6512 58 41 ] ] -RRB- cord-304472-mi5v6512 58 42 . . . cord-304472-mi5v6512 59 1 Indeed indeed RB cord-304472-mi5v6512 59 2 , , , cord-304472-mi5v6512 59 3 the the DT cord-304472-mi5v6512 59 4 vaccine vaccine NN cord-304472-mi5v6512 59 5 trials trial NNS cord-304472-mi5v6512 59 6 for for IN cord-304472-mi5v6512 59 7 the the DT cord-304472-mi5v6512 59 8 secondgeneration secondgeneration NN cord-304472-mi5v6512 59 9 live live VBP cord-304472-mi5v6512 59 10 dengue dengue NN cord-304472-mi5v6512 59 11 vaccines vaccine NNS cord-304472-mi5v6512 59 12 take take VBP cord-304472-mi5v6512 59 13 these these DT cord-304472-mi5v6512 59 14 trial trial NN cord-304472-mi5v6512 59 15 specifications specification NNS cord-304472-mi5v6512 59 16 into into IN cord-304472-mi5v6512 59 17 account account NN cord-304472-mi5v6512 59 18 . . . cord-304472-mi5v6512 60 1 Non non JJ cord-304472-mi5v6512 60 2 - - JJ cord-304472-mi5v6512 60 3 structural structural JJ cord-304472-mi5v6512 60 4 proteins protein NNS cord-304472-mi5v6512 60 5 of of IN cord-304472-mi5v6512 60 6 the the DT cord-304472-mi5v6512 60 7 dengue dengue NN cord-304472-mi5v6512 60 8 virus virus NN cord-304472-mi5v6512 60 9 backbone backbone NN cord-304472-mi5v6512 60 10 are be VBP cord-304472-mi5v6512 60 11 at at IN cord-304472-mi5v6512 60 12 least least JJS cord-304472-mi5v6512 60 13 partially partially RB cord-304472-mi5v6512 60 14 present present JJ cord-304472-mi5v6512 60 15 in in IN cord-304472-mi5v6512 60 16 second second JJ cord-304472-mi5v6512 60 17 generation generation NN cord-304472-mi5v6512 60 18 dengue dengue NN cord-304472-mi5v6512 60 19 vaccines vaccine NNS cord-304472-mi5v6512 60 20 . . . cord-304472-mi5v6512 61 1 Two two CD cord-304472-mi5v6512 61 2 chimeric chimeric JJ cord-304472-mi5v6512 61 3 live live NN cord-304472-mi5v6512 61 4 - - HYPH cord-304472-mi5v6512 61 5 attenuated attenuate VBN cord-304472-mi5v6512 61 6 dengue dengue NN cord-304472-mi5v6512 61 7 vaccines vaccine NNS cord-304472-mi5v6512 61 8 are be VBP cord-304472-mi5v6512 61 9 now now RB cord-304472-mi5v6512 61 10 in in IN cord-304472-mi5v6512 61 11 Phase phase NN cord-304472-mi5v6512 61 12 3 3 CD cord-304472-mi5v6512 61 13 trials trial NNS cord-304472-mi5v6512 61 14 : : : cord-304472-mi5v6512 61 15 one one CD cord-304472-mi5v6512 61 16 developed develop VBN cord-304472-mi5v6512 61 17 by by IN cord-304472-mi5v6512 61 18 Takeda Takeda NNP cord-304472-mi5v6512 61 19 ( ( -LRB- cord-304472-mi5v6512 61 20 TAK-003 tak-003 NN cord-304472-mi5v6512 61 21 ) ) -RRB- cord-304472-mi5v6512 61 22 and and CC cord-304472-mi5v6512 61 23 one one CD cord-304472-mi5v6512 61 24 by by IN cord-304472-mi5v6512 61 25 the the DT cord-304472-mi5v6512 61 26 National National NNP cord-304472-mi5v6512 61 27 Institute Institute NNP cord-304472-mi5v6512 61 28 of of IN cord-304472-mi5v6512 61 29 Allergy Allergy NNP cord-304472-mi5v6512 61 30 and and CC cord-304472-mi5v6512 61 31 Infectious Infectious NNP cord-304472-mi5v6512 61 32 Diseases Diseases NNPS cord-304472-mi5v6512 62 1 ( ( -LRB- cord-304472-mi5v6512 63 1 TV003 TV003 NNP cord-304472-mi5v6512 63 2 / / SYM cord-304472-mi5v6512 63 3 TV005 TV005 NNP cord-304472-mi5v6512 63 4 ) ) -RRB- cord-304472-mi5v6512 63 5 ( ( -LRB- cord-304472-mi5v6512 63 6 Table table NN cord-304472-mi5v6512 63 7 1 1 CD cord-304472-mi5v6512 63 8 ) ) -RRB- cord-304472-mi5v6512 63 9 . . . cord-304472-mi5v6512 64 1 ( ( -LRB- cord-304472-mi5v6512 64 2 1 1 LS cord-304472-mi5v6512 64 3 ) ) -RRB- cord-304472-mi5v6512 64 4 Takeda Takeda NNP cord-304472-mi5v6512 64 5 's 's POS cord-304472-mi5v6512 65 1 TAK-003 tak-003 IN cord-304472-mi5v6512 65 2 Takeda Takeda NNP cord-304472-mi5v6512 65 3 's 's POS cord-304472-mi5v6512 65 4 live live RB cord-304472-mi5v6512 65 5 - - HYPH cord-304472-mi5v6512 65 6 attenuated attenuated JJ cord-304472-mi5v6512 65 7 tetravalent tetravalent NN cord-304472-mi5v6512 65 8 dengue dengue NN cord-304472-mi5v6512 65 9 vaccine vaccine NN cord-304472-mi5v6512 65 10 candidate candidate NN cord-304472-mi5v6512 65 11 comprises comprise VBZ cord-304472-mi5v6512 65 12 an an DT cord-304472-mi5v6512 65 13 attenuated attenuated JJ cord-304472-mi5v6512 65 14 DENV-2 DENV-2 NNP cord-304472-mi5v6512 65 15 strain strain NN cord-304472-mi5v6512 65 16 plus plus CC cord-304472-mi5v6512 65 17 chimeric chimeric JJ cord-304472-mi5v6512 65 18 viruses virus NNS cord-304472-mi5v6512 65 19 containing contain VBG cord-304472-mi5v6512 65 20 the the DT cord-304472-mi5v6512 65 21 prM prm JJ cord-304472-mi5v6512 65 22 and and CC cord-304472-mi5v6512 65 23 E e NN cord-304472-mi5v6512 65 24 genes gene NNS cord-304472-mi5v6512 65 25 of of IN cord-304472-mi5v6512 65 26 DENV-1 DENV-1 NNS cord-304472-mi5v6512 65 27 , , , cord-304472-mi5v6512 65 28 DENV-3 denv-3 NN cord-304472-mi5v6512 65 29 and and CC cord-304472-mi5v6512 65 30 DENV-4 DENV-4 NNP cord-304472-mi5v6512 65 31 cloned clone VBD cord-304472-mi5v6512 65 32 into into IN cord-304472-mi5v6512 65 33 the the DT cord-304472-mi5v6512 65 34 attenuated attenuated JJ cord-304472-mi5v6512 65 35 DENV-2 DENV-2 NNP cord-304472-mi5v6512 65 36 ' ' POS cord-304472-mi5v6512 65 37 backbone backbone NN cord-304472-mi5v6512 65 38 ' ' '' cord-304472-mi5v6512 65 39 [ [ -LRB- cord-304472-mi5v6512 65 40 31 31 CD cord-304472-mi5v6512 65 41 ] ] -RRB- cord-304472-mi5v6512 65 42 . . . cord-304472-mi5v6512 66 1 The the DT cord-304472-mi5v6512 66 2 difference difference NN cord-304472-mi5v6512 66 3 to to IN cord-304472-mi5v6512 66 4 Dengvaxia Dengvaxia NNP cord-304472-mi5v6512 66 5 therefore therefore RB cord-304472-mi5v6512 66 6 is be VBZ cord-304472-mi5v6512 66 7 the the DT cord-304472-mi5v6512 66 8 presence presence NN cord-304472-mi5v6512 66 9 of of IN cord-304472-mi5v6512 66 10 non non JJ cord-304472-mi5v6512 66 11 - - JJ cord-304472-mi5v6512 66 12 structural structural JJ cord-304472-mi5v6512 66 13 proteins protein NNS cord-304472-mi5v6512 66 14 due due JJ cord-304472-mi5v6512 66 15 to to IN cord-304472-mi5v6512 66 16 the the DT cord-304472-mi5v6512 66 17 DENV2 denv2 NN cord-304472-mi5v6512 66 18 backbone backbone NN cord-304472-mi5v6512 66 19 . . . cord-304472-mi5v6512 67 1 TAD-003 TAD-003 NNP cord-304472-mi5v6512 67 2 induces induce VBZ cord-304472-mi5v6512 67 3 crossreactive crossreactive NNP cord-304472-mi5v6512 67 4 T T NNP cord-304472-mi5v6512 67 5 cell cell NN cord-304472-mi5v6512 67 6 - - HYPH cord-304472-mi5v6512 67 7 mediated mediate VBN cord-304472-mi5v6512 67 8 responses response NNS cord-304472-mi5v6512 67 9 that that WDT cord-304472-mi5v6512 67 10 may may MD cord-304472-mi5v6512 67 11 be be VB cord-304472-mi5v6512 67 12 necessary necessary JJ cord-304472-mi5v6512 67 13 for for IN cord-304472-mi5v6512 67 14 broad broad JJ cord-304472-mi5v6512 67 15 protection protection NN cord-304472-mi5v6512 67 16 against against IN cord-304472-mi5v6512 67 17 dengue dengue NN cord-304472-mi5v6512 67 18 fever fever NN cord-304472-mi5v6512 67 19 [ [ -LRB- cord-304472-mi5v6512 67 20 31 31 CD cord-304472-mi5v6512 67 21 , , , cord-304472-mi5v6512 67 22 32 32 CD cord-304472-mi5v6512 67 23 ] ] -RRB- cord-304472-mi5v6512 67 24 . . . cord-304472-mi5v6512 68 1 In in IN cord-304472-mi5v6512 68 2 agreement agreement NN cord-304472-mi5v6512 68 3 with with IN cord-304472-mi5v6512 68 4 WHO who WP cord-304472-mi5v6512 68 5 's 's POS cord-304472-mi5v6512 68 6 prequalification prequalification NN cord-304472-mi5v6512 68 7 requirements requirement NNS cord-304472-mi5v6512 68 8 for for IN cord-304472-mi5v6512 68 9 dengue dengue NN cord-304472-mi5v6512 68 10 vaccines vaccine NNS cord-304472-mi5v6512 68 11 , , , cord-304472-mi5v6512 68 12 Takeda Takeda NNP cord-304472-mi5v6512 68 13 has have VBZ cord-304472-mi5v6512 68 14 manufactured manufacture VBN cord-304472-mi5v6512 68 15 a a DT cord-304472-mi5v6512 68 16 lyophilized lyophilized JJ cord-304472-mi5v6512 68 17 formulation formulation NN cord-304472-mi5v6512 68 18 of of IN cord-304472-mi5v6512 68 19 TAK-003 tak-003 NN cord-304472-mi5v6512 68 20 that that WDT cord-304472-mi5v6512 68 21 allows allow VBZ cord-304472-mi5v6512 68 22 stable stable JJ cord-304472-mi5v6512 68 23 storage storage NN cord-304472-mi5v6512 68 24 at at IN cord-304472-mi5v6512 68 25 +2 +2 HYPH cord-304472-mi5v6512 68 26 degrees degree NNS cord-304472-mi5v6512 68 27 C c NN cord-304472-mi5v6512 68 28 to to IN cord-304472-mi5v6512 68 29 +8 +8 CD cord-304472-mi5v6512 68 30 degrees degree NNS cord-304472-mi5v6512 68 31 C. c. NN cord-304472-mi5v6512 69 1 In in IN cord-304472-mi5v6512 69 2 a a DT cord-304472-mi5v6512 69 3 randomized randomized JJ cord-304472-mi5v6512 69 4 , , , cord-304472-mi5v6512 69 5 doubleblind doubleblind NN cord-304472-mi5v6512 69 6 , , , cord-304472-mi5v6512 69 7 phase phase NN cord-304472-mi5v6512 69 8 2 2 CD cord-304472-mi5v6512 69 9 study study NN cord-304472-mi5v6512 69 10 ( ( -LRB- cord-304472-mi5v6512 69 11 NCT02193087 NCT02193087 NNP cord-304472-mi5v6512 69 12 ) ) -RRB- cord-304472-mi5v6512 69 13 in in IN cord-304472-mi5v6512 69 14 1002 1002 CD cord-304472-mi5v6512 69 15 healthy healthy JJ cord-304472-mi5v6512 69 16 dengue dengue NN cord-304472-mi5v6512 69 17 - - HYPH cord-304472-mi5v6512 69 18 naive naive JJ cord-304472-mi5v6512 69 19 adults adult NNS cord-304472-mi5v6512 69 20 , , , cord-304472-mi5v6512 69 21 18 18 CD cord-304472-mi5v6512 69 22 - - SYM cord-304472-mi5v6512 69 23 49 49 CD cord-304472-mi5v6512 69 24 years year NNS cord-304472-mi5v6512 69 25 of of IN cord-304472-mi5v6512 69 26 age age NN cord-304472-mi5v6512 69 27 , , , cord-304472-mi5v6512 69 28 GMTs gmt NNS cord-304472-mi5v6512 69 29 and and CC cord-304472-mi5v6512 69 30 seropositivity seropositivity NN cord-304472-mi5v6512 69 31 rates rate NNS cord-304472-mi5v6512 69 32 to to IN cord-304472-mi5v6512 69 33 all all DT cord-304472-mi5v6512 69 34 four four CD cord-304472-mi5v6512 69 35 serotypes serotype NNS cord-304472-mi5v6512 69 36 were be VBD cord-304472-mi5v6512 69 37 achieved achieve VBN cord-304472-mi5v6512 69 38 [ [ -LRB- cord-304472-mi5v6512 69 39 33 33 CD cord-304472-mi5v6512 69 40 ] ] -RRB- cord-304472-mi5v6512 69 41 . . . cord-304472-mi5v6512 70 1 A a DT cord-304472-mi5v6512 70 2 Multi multi JJ cord-304472-mi5v6512 70 3 - - JJ cord-304472-mi5v6512 70 4 Color color NN cord-304472-mi5v6512 70 5 FluoroSpot FluoroSpot NNP cord-304472-mi5v6512 70 6 ( ( -LRB- cord-304472-mi5v6512 70 7 MCF MCF NNP cord-304472-mi5v6512 70 8 ) ) -RRB- cord-304472-mi5v6512 70 9 assay assay NN cord-304472-mi5v6512 70 10 enabled enable VBD cord-304472-mi5v6512 70 11 quantitation quantitation NN cord-304472-mi5v6512 70 12 of of IN cord-304472-mi5v6512 70 13 serotype serotype NN cord-304472-mi5v6512 70 14 - - HYPH cord-304472-mi5v6512 70 15 specific specific JJ cord-304472-mi5v6512 70 16 and and CC cord-304472-mi5v6512 70 17 cross cross JJ cord-304472-mi5v6512 70 18 - - JJ cord-304472-mi5v6512 70 19 reactive reactive JJ cord-304472-mi5v6512 70 20 individual individual JJ cord-304472-mi5v6512 70 21 memory memory NN cord-304472-mi5v6512 70 22 B b NN cord-304472-mi5v6512 70 23 cells cell NNS cord-304472-mi5v6512 70 24 ( ( -LRB- cord-304472-mi5v6512 70 25 MBCs mbc NNS cord-304472-mi5v6512 70 26 ) ) -RRB- cord-304472-mi5v6512 70 27 secreting secrete VBG cord-304472-mi5v6512 70 28 DENV denv NN cord-304472-mi5v6512 70 29 - - HYPH cord-304472-mi5v6512 70 30 specific specific JJ cord-304472-mi5v6512 70 31 antibodies antibody NNS cord-304472-mi5v6512 70 32 in in IN cord-304472-mi5v6512 70 33 a a DT cord-304472-mi5v6512 70 34 polyclonal polyclonal JJ cord-304472-mi5v6512 70 35 mixture mixture NN cord-304472-mi5v6512 70 36 [ [ -LRB- cord-304472-mi5v6512 70 37 34 34 CD cord-304472-mi5v6512 70 38 ] ] -RRB- cord-304472-mi5v6512 70 39 . . . cord-304472-mi5v6512 71 1 Using use VBG cord-304472-mi5v6512 71 2 the the DT cord-304472-mi5v6512 71 3 MCF MCF NNP cord-304472-mi5v6512 71 4 assay assay NN cord-304472-mi5v6512 71 5 , , , cord-304472-mi5v6512 71 6 type type NN cord-304472-mi5v6512 71 7 - - HYPH cord-304472-mi5v6512 71 8 specific specific JJ cord-304472-mi5v6512 71 9 and and CC cord-304472-mi5v6512 71 10 cross cross JJ cord-304472-mi5v6512 71 11 - - JJ cord-304472-mi5v6512 71 12 reactive reactive JJ cord-304472-mi5v6512 71 13 MBC MBC NNP cord-304472-mi5v6512 71 14 responses response NNS cord-304472-mi5v6512 71 15 were be VBD cord-304472-mi5v6512 71 16 investigated investigate VBN cord-304472-mi5v6512 71 17 ; ; : cord-304472-mi5v6512 71 18 the the DT cord-304472-mi5v6512 71 19 results result NNS cord-304472-mi5v6512 71 20 demonstrate demonstrate VBP cord-304472-mi5v6512 71 21 that that IN cord-304472-mi5v6512 71 22 , , , cord-304472-mi5v6512 71 23 unlike unlike IN cord-304472-mi5v6512 71 24 primary primary JJ cord-304472-mi5v6512 71 25 or or CC cord-304472-mi5v6512 71 26 secondary secondary JJ cord-304472-mi5v6512 71 27 natural natural JJ cord-304472-mi5v6512 71 28 DENV DENV NNP cord-304472-mi5v6512 71 29 infection infection NN cord-304472-mi5v6512 71 30 , , , cord-304472-mi5v6512 71 31 tetravalent tetravalent NN cord-304472-mi5v6512 71 32 vaccination vaccination NN cord-304472-mi5v6512 71 33 elicits elicit VBZ cord-304472-mi5v6512 71 34 tetravalent tetravalent NN cord-304472-mi5v6512 71 35 type type NN cord-304472-mi5v6512 71 36 - - HYPH cord-304472-mi5v6512 71 37 specific specific JJ cord-304472-mi5v6512 71 38 MBCs mbc NNS cord-304472-mi5v6512 71 39 , , , cord-304472-mi5v6512 71 40 and and CC cord-304472-mi5v6512 71 41 thus thus RB cord-304472-mi5v6512 71 42 all all DT cord-304472-mi5v6512 71 43 four four CD cord-304472-mi5v6512 71 44 components component NNS cord-304472-mi5v6512 71 45 of of IN cord-304472-mi5v6512 71 46 TAK-003 tak-003 NN cord-304472-mi5v6512 71 47 contribute contribute VB cord-304472-mi5v6512 71 48 to to IN cord-304472-mi5v6512 71 49 the the DT cord-304472-mi5v6512 71 50 DENV DENV NNP cord-304472-mi5v6512 71 51 - - HYPH cord-304472-mi5v6512 71 52 specific specific JJ cord-304472-mi5v6512 71 53 MBC MBC NNP cord-304472-mi5v6512 71 54 response response NN cord-304472-mi5v6512 71 55 following follow VBG cord-304472-mi5v6512 71 56 vaccination vaccination NN cord-304472-mi5v6512 71 57 [ [ -LRB- cord-304472-mi5v6512 71 58 33 33 CD cord-304472-mi5v6512 71 59 ] ] -RRB- cord-304472-mi5v6512 71 60 . . . cord-304472-mi5v6512 72 1 The the DT cord-304472-mi5v6512 72 2 Phase phase NN cord-304472-mi5v6512 72 3 2 2 CD cord-304472-mi5v6512 72 4 trials trial NNS cord-304472-mi5v6512 72 5 on on IN cord-304472-mi5v6512 72 6 immunogenicity immunogenicity NN cord-304472-mi5v6512 72 7 showed show VBD cord-304472-mi5v6512 72 8 that that IN cord-304472-mi5v6512 72 9 geometric geometric JJ cord-304472-mi5v6512 72 10 mean mean NN cord-304472-mi5v6512 72 11 titers titer NNS cord-304472-mi5v6512 72 12 ( ( -LRB- cord-304472-mi5v6512 72 13 GMTs gmt NNS cord-304472-mi5v6512 72 14 ) ) -RRB- cord-304472-mi5v6512 72 15 against against IN cord-304472-mi5v6512 72 16 DENV DENV NNP cord-304472-mi5v6512 72 17 1 1 CD cord-304472-mi5v6512 72 18 , , , cord-304472-mi5v6512 72 19 DENV DENV NNP cord-304472-mi5v6512 72 20 3 3 CD cord-304472-mi5v6512 72 21 , , , cord-304472-mi5v6512 72 22 and and CC cord-304472-mi5v6512 72 23 DENV DENV NNP cord-304472-mi5v6512 72 24 4 4 CD cord-304472-mi5v6512 72 25 were be VBD cord-304472-mi5v6512 72 26 lower low JJR cord-304472-mi5v6512 72 27 in in IN cord-304472-mi5v6512 72 28 participants participant NNS cord-304472-mi5v6512 72 29 who who WP cord-304472-mi5v6512 72 30 were be VBD cord-304472-mi5v6512 72 31 seronegative seronegative JJ cord-304472-mi5v6512 72 32 and and CC cord-304472-mi5v6512 72 33 receiving receive VBG cord-304472-mi5v6512 72 34 one one CD cord-304472-mi5v6512 72 35 primary primary JJ cord-304472-mi5v6512 72 36 dose dose NN cord-304472-mi5v6512 72 37 than than IN cord-304472-mi5v6512 72 38 in in IN cord-304472-mi5v6512 72 39 those those DT cord-304472-mi5v6512 72 40 who who WP cord-304472-mi5v6512 72 41 received receive VBD cord-304472-mi5v6512 72 42 the the DT cord-304472-mi5v6512 72 43 two two CD cord-304472-mi5v6512 72 44 - - HYPH cord-304472-mi5v6512 72 45 dose dose NN cord-304472-mi5v6512 72 46 primary primary JJ cord-304472-mi5v6512 72 47 series series NN cord-304472-mi5v6512 72 48 or or CC cord-304472-mi5v6512 72 49 one one CD cord-304472-mi5v6512 72 50 primary primary JJ cord-304472-mi5v6512 72 51 dose dose NN cord-304472-mi5v6512 72 52 plus plus CC cord-304472-mi5v6512 72 53 a a DT cord-304472-mi5v6512 72 54 1-year 1-year CD cord-304472-mi5v6512 72 55 booster booster NN cord-304472-mi5v6512 72 56 [ [ -LRB- cord-304472-mi5v6512 72 57 30 30 CD cord-304472-mi5v6512 72 58 ] ] -RRB- cord-304472-mi5v6512 72 59 . . . cord-304472-mi5v6512 73 1 These these DT cord-304472-mi5v6512 73 2 immunogenicity immunogenicity NN cord-304472-mi5v6512 73 3 results result NNS cord-304472-mi5v6512 73 4 suggested suggest VBD cord-304472-mi5v6512 73 5 that that IN cord-304472-mi5v6512 73 6 Phase phase NN cord-304472-mi5v6512 73 7 3 3 CD cord-304472-mi5v6512 73 8 trials trial NNS cord-304472-mi5v6512 73 9 should should MD cord-304472-mi5v6512 73 10 be be VB cord-304472-mi5v6512 73 11 conducted conduct VBN cord-304472-mi5v6512 73 12 with with IN cord-304472-mi5v6512 73 13 a a DT cord-304472-mi5v6512 73 14 two two CD cord-304472-mi5v6512 73 15 dose dose JJ cord-304472-mi5v6512 73 16 regimen regimen NN cord-304472-mi5v6512 73 17 to to TO cord-304472-mi5v6512 73 18 improve improve VB cord-304472-mi5v6512 73 19 immunogenicity immunogenicity NN cord-304472-mi5v6512 73 20 in in IN cord-304472-mi5v6512 73 21 seronegative seronegative JJ cord-304472-mi5v6512 73 22 individuals individual NNS cord-304472-mi5v6512 73 23 . . . cord-304472-mi5v6512 74 1 At at IN cord-304472-mi5v6512 74 2 Month month NN cord-304472-mi5v6512 74 3 36 36 CD cord-304472-mi5v6512 74 4 , , , cord-304472-mi5v6512 74 5 seropositivity seropositivity NN cord-304472-mi5v6512 74 6 rates rate NNS cord-304472-mi5v6512 74 7 were be VBD cord-304472-mi5v6512 74 8 97.3 97.3 CD cord-304472-mi5v6512 74 9 % % NN cord-304472-mi5v6512 74 10 , , , cord-304472-mi5v6512 74 11 98.7 98.7 CD cord-304472-mi5v6512 74 12 % % NN cord-304472-mi5v6512 74 13 , , , cord-304472-mi5v6512 74 14 88.0 88.0 CD cord-304472-mi5v6512 74 15 % % NN cord-304472-mi5v6512 74 16 and and CC cord-304472-mi5v6512 74 17 56.0 56.0 CD cord-304472-mi5v6512 74 18 % % NN cord-304472-mi5v6512 74 19 for for IN cord-304472-mi5v6512 74 20 DENV-1 DENV-1 NNS cord-304472-mi5v6512 74 21 , , , cord-304472-mi5v6512 74 22 DENV-2 DENV-2 NNP cord-304472-mi5v6512 74 23 , , , cord-304472-mi5v6512 74 24 DENV-3 denv-3 NN cord-304472-mi5v6512 74 25 and and CC cord-304472-mi5v6512 74 26 DENV-4 DENV-4 NNP cord-304472-mi5v6512 74 27 , , , cord-304472-mi5v6512 74 28 respectively respectively RB cord-304472-mi5v6512 74 29 [ [ -LRB- cord-304472-mi5v6512 74 30 35 35 CD cord-304472-mi5v6512 74 31 ] ] -RRB- cord-304472-mi5v6512 74 32 . . . cord-304472-mi5v6512 75 1 A a DT cord-304472-mi5v6512 75 2 Phase phase NN cord-304472-mi5v6512 75 3 3 3 CD cord-304472-mi5v6512 75 4 trial trial NN cord-304472-mi5v6512 75 5 in in IN cord-304472-mi5v6512 75 6 more more JJR cord-304472-mi5v6512 75 7 than than IN cord-304472-mi5v6512 75 8 20 20 CD cord-304472-mi5v6512 75 9 000 000 CD cord-304472-mi5v6512 75 10 healthy healthy JJ cord-304472-mi5v6512 75 11 children child NNS cord-304472-mi5v6512 75 12 and and CC cord-304472-mi5v6512 75 13 adolescents adolescent NNS cord-304472-mi5v6512 75 14 4 4 CD cord-304472-mi5v6512 75 15 - - SYM cord-304472-mi5v6512 75 16 16 16 CD cord-304472-mi5v6512 75 17 years year NNS cord-304472-mi5v6512 75 18 of of IN cord-304472-mi5v6512 75 19 age age NN cord-304472-mi5v6512 75 20 to to TO cord-304472-mi5v6512 75 21 receive receive VB cord-304472-mi5v6512 75 22 two two CD cord-304472-mi5v6512 75 23 doses dose NNS cord-304472-mi5v6512 75 24 of of IN cord-304472-mi5v6512 75 25 vaccine vaccine NN cord-304472-mi5v6512 75 26 or or CC cord-304472-mi5v6512 75 27 placebo placebo NN cord-304472-mi5v6512 75 28 is be VBZ cord-304472-mi5v6512 75 29 currently currently RB cord-304472-mi5v6512 75 30 being be VBG cord-304472-mi5v6512 75 31 conducted conduct VBN cord-304472-mi5v6512 75 32 in in IN cord-304472-mi5v6512 75 33 8 8 CD cord-304472-mi5v6512 75 34 countries country NNS cord-304472-mi5v6512 75 35 in in IN cord-304472-mi5v6512 75 36 Asia Asia NNP cord-304472-mi5v6512 75 37 and and CC cord-304472-mi5v6512 75 38 Latin Latin NNP cord-304472-mi5v6512 75 39 America America NNP cord-304472-mi5v6512 75 40 . . . cord-304472-mi5v6512 76 1 In in IN cord-304472-mi5v6512 76 2 summary summary NN cord-304472-mi5v6512 76 3 , , , cord-304472-mi5v6512 76 4 although although IN cord-304472-mi5v6512 76 5 the the DT cord-304472-mi5v6512 76 6 Takeda Takeda NNP cord-304472-mi5v6512 76 7 vaccine vaccine NN cord-304472-mi5v6512 76 8 appears appear VBZ cord-304472-mi5v6512 76 9 much much RB cord-304472-mi5v6512 76 10 less less JJR cord-304472-mi5v6512 76 11 serostatus serostatus NN cord-304472-mi5v6512 76 12 dependent dependent JJ cord-304472-mi5v6512 76 13 compared compare VBN cord-304472-mi5v6512 76 14 with with IN cord-304472-mi5v6512 77 1 CYD CYD NNP cord-304472-mi5v6512 77 2 - - HYPH cord-304472-mi5v6512 77 3 TDV TDV NNP cord-304472-mi5v6512 77 4 and and CC cord-304472-mi5v6512 77 5 efficacy efficacy NN cord-304472-mi5v6512 77 6 data datum NNS cord-304472-mi5v6512 77 7 look look VBP cord-304472-mi5v6512 77 8 promising promising JJ cord-304472-mi5v6512 77 9 , , , cord-304472-mi5v6512 77 10 some some DT cord-304472-mi5v6512 77 11 complex complex JJ cord-304472-mi5v6512 77 12 nuances nuance NNS cord-304472-mi5v6512 77 13 for for IN cord-304472-mi5v6512 77 14 serotypes serotypes NN cord-304472-mi5v6512 77 15 3 3 CD cord-304472-mi5v6512 77 16 and and CC cord-304472-mi5v6512 77 17 4 4 CD cord-304472-mi5v6512 77 18 will will MD cord-304472-mi5v6512 77 19 require require VB cord-304472-mi5v6512 77 20 extended extended JJ cord-304472-mi5v6512 77 21 follow follow NN cord-304472-mi5v6512 77 22 - - HYPH cord-304472-mi5v6512 77 23 up up NN cord-304472-mi5v6512 77 24 , , , cord-304472-mi5v6512 77 25 and and CC cord-304472-mi5v6512 77 26 careful careful JJ cord-304472-mi5v6512 77 27 balancing balancing NN cord-304472-mi5v6512 77 28 by by IN cord-304472-mi5v6512 77 29 regulators regulator NNS cord-304472-mi5v6512 77 30 and and CC cord-304472-mi5v6512 77 31 policy policy NN cord-304472-mi5v6512 77 32 makers maker NNS cord-304472-mi5v6512 77 33 in in IN cord-304472-mi5v6512 77 34 determining determine VBG cord-304472-mi5v6512 77 35 the the DT cord-304472-mi5v6512 77 36 potential potential JJ cord-304472-mi5v6512 77 37 utility utility NN cord-304472-mi5v6512 77 38 and and CC cord-304472-mi5v6512 77 39 safety safety NN cord-304472-mi5v6512 77 40 of of IN cord-304472-mi5v6512 77 41 this this DT cord-304472-mi5v6512 77 42 vaccine vaccine NN cord-304472-mi5v6512 77 43 [ [ -LRB- cord-304472-mi5v6512 77 44 30 30 CD cord-304472-mi5v6512 77 45 ] ] -RRB- cord-304472-mi5v6512 77 46 . . . cord-304472-mi5v6512 78 1 ( ( -LRB- cord-304472-mi5v6512 78 2 2 2 LS cord-304472-mi5v6512 78 3 ) ) -RRB- cord-304472-mi5v6512 79 1 National National NNP cord-304472-mi5v6512 79 2 institute institute NNP cord-304472-mi5v6512 79 3 of of IN cord-304472-mi5v6512 79 4 allergy allergy NNP cord-304472-mi5v6512 79 5 and and CC cord-304472-mi5v6512 79 6 infectious infectious JJ cord-304472-mi5v6512 79 7 diseases disease NNS cord-304472-mi5v6512 80 1 ( ( -LRB- cord-304472-mi5v6512 80 2 TV003 TV003 NNP cord-304472-mi5v6512 80 3 / / , cord-304472-mi5v6512 80 4 TV005)/Butantan TV005)/Butantan NNP cord-304472-mi5v6512 81 1 This this DT cord-304472-mi5v6512 81 2 vaccine vaccine NN cord-304472-mi5v6512 81 3 comprises comprise VBZ cord-304472-mi5v6512 81 4 3 3 CD cord-304472-mi5v6512 81 5 full full JJ cord-304472-mi5v6512 81 6 - - HYPH cord-304472-mi5v6512 81 7 length length NN cord-304472-mi5v6512 81 8 DENV DENV NNS cord-304472-mi5v6512 81 9 attenuated attenuate VBN cord-304472-mi5v6512 81 10 by by IN cord-304472-mi5v6512 81 11 one one CD cord-304472-mi5v6512 81 12 or or CC cord-304472-mi5v6512 81 13 more more JJR cord-304472-mi5v6512 81 14 deletions deletion NNS cord-304472-mi5v6512 81 15 in in IN cord-304472-mi5v6512 81 16 the the DT cord-304472-mi5v6512 81 17 3 3 CD cord-304472-mi5v6512 81 18 0 0 CD cord-304472-mi5v6512 81 19 untranslated untranslated JJ cord-304472-mi5v6512 81 20 region region NN cord-304472-mi5v6512 81 21 , , , cord-304472-mi5v6512 81 22 while while IN cord-304472-mi5v6512 81 23 the the DT cord-304472-mi5v6512 81 24 fourth fourth JJ cord-304472-mi5v6512 81 25 component component NN cord-304472-mi5v6512 81 26 is be VBZ cord-304472-mi5v6512 81 27 a a DT cord-304472-mi5v6512 81 28 chimeric chimeric JJ cord-304472-mi5v6512 81 29 virus virus NN cord-304472-mi5v6512 81 30 in in IN cord-304472-mi5v6512 81 31 which which WDT cord-304472-mi5v6512 81 32 the the DT cord-304472-mi5v6512 81 33 prM prm JJ cord-304472-mi5v6512 81 34 and and CC cord-304472-mi5v6512 81 35 E e NN cord-304472-mi5v6512 81 36 proteins protein NNS cord-304472-mi5v6512 81 37 of of IN cord-304472-mi5v6512 81 38 DENV-2 DENV-2 NNP cord-304472-mi5v6512 81 39 replace replace VBP cord-304472-mi5v6512 81 40 those those DT cord-304472-mi5v6512 81 41 of of IN cord-304472-mi5v6512 81 42 DENV-4 DENV-4 NNP cord-304472-mi5v6512 81 43 in in IN cord-304472-mi5v6512 81 44 the the DT cord-304472-mi5v6512 81 45 DEN4D30 den4d30 CD cord-304472-mi5v6512 81 46 background background NN cord-304472-mi5v6512 81 47 [ [ -LRB- cord-304472-mi5v6512 81 48 38 38 CD cord-304472-mi5v6512 81 49 ] ] -RRB- cord-304472-mi5v6512 81 50 . . . cord-304472-mi5v6512 82 1 Thus thus RB cord-304472-mi5v6512 82 2 , , , cord-304472-mi5v6512 82 3 this this DT cord-304472-mi5v6512 82 4 vaccine vaccine NN cord-304472-mi5v6512 82 5 carries carry VBZ cord-304472-mi5v6512 82 6 the the DT cord-304472-mi5v6512 82 7 full full JJ cord-304472-mi5v6512 82 8 - - HYPH cord-304472-mi5v6512 82 9 genomic genomic JJ cord-304472-mi5v6512 82 10 backbone backbone NN cord-304472-mi5v6512 82 11 of of IN cord-304472-mi5v6512 82 12 three three CD cord-304472-mi5v6512 82 13 dengue dengue NN cord-304472-mi5v6512 82 14 serotypes serotype NNS cord-304472-mi5v6512 82 15 , , , cord-304472-mi5v6512 82 16 except except IN cord-304472-mi5v6512 82 17 for for IN cord-304472-mi5v6512 82 18 DENV2 denv2 NN cord-304472-mi5v6512 82 19 . . . cord-304472-mi5v6512 83 1 The the DT cord-304472-mi5v6512 83 2 capacity capacity NN cord-304472-mi5v6512 83 3 to to TO cord-304472-mi5v6512 83 4 elicit elicit VB cord-304472-mi5v6512 83 5 CD4 CD4 NNP cord-304472-mi5v6512 83 6 + + CC cord-304472-mi5v6512 83 7 cell cell NN cord-304472-mi5v6512 83 8 responses response NNS cord-304472-mi5v6512 83 9 closely closely RB cord-304472-mi5v6512 83 10 mirrors mirror NNS cord-304472-mi5v6512 83 11 those those DT cord-304472-mi5v6512 83 12 observed observe VBN cord-304472-mi5v6512 83 13 in in IN cord-304472-mi5v6512 83 14 a a DT cord-304472-mi5v6512 83 15 population population NN cord-304472-mi5v6512 83 16 associated associate VBN cord-304472-mi5v6512 83 17 with with IN cord-304472-mi5v6512 83 18 natural natural JJ cord-304472-mi5v6512 83 19 immunity immunity NN cord-304472-mi5v6512 83 20 [ [ -LRB- cord-304472-mi5v6512 83 21 39 39 CD cord-304472-mi5v6512 83 22 ] ] -RRB- cord-304472-mi5v6512 83 23 . . . cord-304472-mi5v6512 84 1 A a DT cord-304472-mi5v6512 84 2 single single JJ cord-304472-mi5v6512 84 3 - - HYPH cord-304472-mi5v6512 84 4 dose dose NN cord-304472-mi5v6512 84 5 induces induce VBZ cord-304472-mi5v6512 84 6 robust robust JJ cord-304472-mi5v6512 84 7 tetravalent tetravalent NN cord-304472-mi5v6512 84 8 antibody antibody NN cord-304472-mi5v6512 84 9 and and CC cord-304472-mi5v6512 84 10 cellular cellular JJ cord-304472-mi5v6512 84 11 T t NN cord-304472-mi5v6512 84 12 cell cell NN cord-304472-mi5v6512 84 13 responses response NNS cord-304472-mi5v6512 84 14 and and CC cord-304472-mi5v6512 84 15 resulted result VBD cord-304472-mi5v6512 84 16 in in IN cord-304472-mi5v6512 84 17 a a DT cord-304472-mi5v6512 84 18 100 100 CD cord-304472-mi5v6512 84 19 % % NN cord-304472-mi5v6512 84 20 efficacy efficacy NN cord-304472-mi5v6512 84 21 in in IN cord-304472-mi5v6512 84 22 a a DT cord-304472-mi5v6512 84 23 human human JJ cord-304472-mi5v6512 84 24 challenge challenge NN cord-304472-mi5v6512 84 25 study study NN cord-304472-mi5v6512 84 26 [ [ -LRB- cord-304472-mi5v6512 84 27 40 40 CD cord-304472-mi5v6512 84 28 ] ] -RRB- cord-304472-mi5v6512 84 29 . . . cord-304472-mi5v6512 85 1 Developed develop VBN cord-304472-mi5v6512 85 2 by by IN cord-304472-mi5v6512 85 3 the the DT cord-304472-mi5v6512 85 4 U.S. U.S. NNP cord-304472-mi5v6512 85 5 National National NNP cord-304472-mi5v6512 85 6 Institutes Institutes NNPS cord-304472-mi5v6512 85 7 of of IN cord-304472-mi5v6512 85 8 Health Health NNP cord-304472-mi5v6512 85 9 ( ( -LRB- cord-304472-mi5v6512 85 10 NIH NIH NNP cord-304472-mi5v6512 85 11 / / SYM cord-304472-mi5v6512 85 12 NIAID NIAID NNP cord-304472-mi5v6512 85 13 ) ) -RRB- cord-304472-mi5v6512 85 14 , , , cord-304472-mi5v6512 85 15 it -PRON- PRP cord-304472-mi5v6512 85 16 is be VBZ cord-304472-mi5v6512 85 17 currently currently RB cord-304472-mi5v6512 85 18 in in IN cord-304472-mi5v6512 85 19 a a DT cord-304472-mi5v6512 85 20 Phase phase NN cord-304472-mi5v6512 85 21 3 3 CD cord-304472-mi5v6512 85 22 trial trial NN cord-304472-mi5v6512 85 23 in in IN cord-304472-mi5v6512 85 24 Brazil Brazil NNP cord-304472-mi5v6512 85 25 through through IN cord-304472-mi5v6512 85 26 Butantan Butantan NNP cord-304472-mi5v6512 85 27 , , , cord-304472-mi5v6512 85 28 but but CC cord-304472-mi5v6512 85 29 was be VBD cord-304472-mi5v6512 85 30 also also RB cord-304472-mi5v6512 85 31 licensed license VBN cord-304472-mi5v6512 85 32 to to IN cord-304472-mi5v6512 85 33 Merck Merck NNP cord-304472-mi5v6512 85 34 for for IN cord-304472-mi5v6512 85 35 further further JJ cord-304472-mi5v6512 85 36 development development NN cord-304472-mi5v6512 85 37 outside outside IN cord-304472-mi5v6512 85 38 of of IN cord-304472-mi5v6512 85 39 Brazil Brazil NNP cord-304472-mi5v6512 85 40 . . . cord-304472-mi5v6512 86 1 The the DT cord-304472-mi5v6512 86 2 Butantan Butantan NNP cord-304472-mi5v6512 86 3 Institute Institute NNP cord-304472-mi5v6512 86 4 has have VBZ cord-304472-mi5v6512 86 5 Dengue dengue NN cord-304472-mi5v6512 86 6 vaccine vaccine NN cord-304472-mi5v6512 86 7 development development NN cord-304472-mi5v6512 86 8 Wilder Wilder NNP cord-304472-mi5v6512 86 9 - - HYPH cord-304472-mi5v6512 86 10 Smith Smith NNP cord-304472-mi5v6512 86 11 73 73 CD cord-304472-mi5v6512 86 12 manufactured manufacture VBD cord-304472-mi5v6512 86 13 a a DT cord-304472-mi5v6512 86 14 lyophilized lyophilized JJ cord-304472-mi5v6512 86 15 tetravalent tetravalent NN cord-304472-mi5v6512 86 16 live live RB cord-304472-mi5v6512 86 17 - - HYPH cord-304472-mi5v6512 86 18 attenuated attenuate VBN cord-304472-mi5v6512 86 19 dengue dengue NN cord-304472-mi5v6512 86 20 vaccine vaccine NN cord-304472-mi5v6512 86 21 Butantan Butantan NNP cord-304472-mi5v6512 86 22 - - HYPH cord-304472-mi5v6512 86 23 DV DV NNP cord-304472-mi5v6512 86 24 , , , cord-304472-mi5v6512 86 25 which which WDT cord-304472-mi5v6512 86 26 is be VBZ cord-304472-mi5v6512 86 27 analogous analogous JJ cord-304472-mi5v6512 86 28 to to IN cord-304472-mi5v6512 86 29 the the DT cord-304472-mi5v6512 86 30 US US NNP cord-304472-mi5v6512 86 31 National National NNP cord-304472-mi5v6512 86 32 Institutes Institutes NNPS cord-304472-mi5v6512 86 33 of of IN cord-304472-mi5v6512 86 34 Health Health NNP cord-304472-mi5v6512 86 35 ( ( -LRB- cord-304472-mi5v6512 86 36 NIH NIH NNP cord-304472-mi5v6512 86 37 ) ) -RRB- cord-304472-mi5v6512 87 1 TV003 TV003 NNP cord-304472-mi5v6512 87 2 admixture admixture NN cord-304472-mi5v6512 87 3 [ [ -LRB- cord-304472-mi5v6512 87 4 30 30 CD cord-304472-mi5v6512 87 5 ] ] -RRB- cord-304472-mi5v6512 87 6 . . . cord-304472-mi5v6512 88 1 Seroconversion seroconversion NN cord-304472-mi5v6512 88 2 appears appear VBZ cord-304472-mi5v6512 88 3 to to TO cord-304472-mi5v6512 88 4 be be VB cord-304472-mi5v6512 88 5 high high JJ cord-304472-mi5v6512 88 6 for for IN cord-304472-mi5v6512 88 7 all all DT cord-304472-mi5v6512 88 8 four four CD cord-304472-mi5v6512 88 9 serotypes serotype NNS cord-304472-mi5v6512 88 10 independent independent JJ cord-304472-mi5v6512 88 11 of of IN cord-304472-mi5v6512 88 12 serostatus serostatus NNP cord-304472-mi5v6512 88 13 , , , cord-304472-mi5v6512 88 14 with with IN cord-304472-mi5v6512 88 15 the the DT cord-304472-mi5v6512 88 16 highest high JJS cord-304472-mi5v6512 88 17 for for IN cord-304472-mi5v6512 88 18 DENV DENV NNP cord-304472-mi5v6512 88 19 1 1 CD cord-304472-mi5v6512 88 20 , , , cord-304472-mi5v6512 88 21 3 3 CD cord-304472-mi5v6512 88 22 and and CC cord-304472-mi5v6512 88 23 4 4 CD cord-304472-mi5v6512 88 24 , , , cord-304472-mi5v6512 88 25 and and CC cord-304472-mi5v6512 88 26 the the DT cord-304472-mi5v6512 88 27 lowest low JJS cord-304472-mi5v6512 88 28 for for IN cord-304472-mi5v6512 88 29 DENV DENV NNP cord-304472-mi5v6512 88 30 2 2 CD cord-304472-mi5v6512 88 31 . . . cord-304472-mi5v6512 89 1 To to TO cord-304472-mi5v6512 89 2 determine determine VB cord-304472-mi5v6512 89 3 the the DT cord-304472-mi5v6512 89 4 ability ability NN cord-304472-mi5v6512 89 5 of of IN cord-304472-mi5v6512 89 6 a a DT cord-304472-mi5v6512 89 7 single single JJ cord-304472-mi5v6512 89 8 dose dose NN cord-304472-mi5v6512 89 9 of of IN cord-304472-mi5v6512 89 10 the the DT cord-304472-mi5v6512 89 11 live live JJ cord-304472-mi5v6512 89 12 attenuated attenuated JJ cord-304472-mi5v6512 89 13 tetravalent tetravalent NN cord-304472-mi5v6512 89 14 dengue dengue NN cord-304472-mi5v6512 89 15 vaccine vaccine NN cord-304472-mi5v6512 89 16 TV003 TV003 NNP cord-304472-mi5v6512 89 17 to to TO cord-304472-mi5v6512 89 18 induce induce VB cord-304472-mi5v6512 89 19 a a DT cord-304472-mi5v6512 89 20 suitable suitable JJ cord-304472-mi5v6512 89 21 neutralizing neutralize VBG cord-304472-mi5v6512 89 22 antibody antibody NN cord-304472-mi5v6512 89 23 response response NN cord-304472-mi5v6512 89 24 , , , cord-304472-mi5v6512 89 25 a a DT cord-304472-mi5v6512 89 26 placebo placebo NN cord-304472-mi5v6512 89 27 - - HYPH cord-304472-mi5v6512 89 28 controlled control VBN cord-304472-mi5v6512 89 29 clinical clinical JJ cord-304472-mi5v6512 89 30 trial trial NN cord-304472-mi5v6512 89 31 was be VBD cord-304472-mi5v6512 89 32 performed perform VBN cord-304472-mi5v6512 89 33 in in IN cord-304472-mi5v6512 89 34 48 48 CD cord-304472-mi5v6512 89 35 healthy healthy JJ cord-304472-mi5v6512 89 36 adults adult NNS cord-304472-mi5v6512 89 37 who who WP cord-304472-mi5v6512 89 38 received receive VBD cord-304472-mi5v6512 89 39 2 2 CD cord-304472-mi5v6512 89 40 doses dose NNS cord-304472-mi5v6512 89 41 of of IN cord-304472-mi5v6512 89 42 vaccine vaccine NN cord-304472-mi5v6512 89 43 or or CC cord-304472-mi5v6512 89 44 placebo placebo NN cord-304472-mi5v6512 89 45 administered administer VBN cord-304472-mi5v6512 89 46 12 12 CD cord-304472-mi5v6512 89 47 months month NNS cord-304472-mi5v6512 89 48 apart apart RB cord-304472-mi5v6512 89 49 . . . cord-304472-mi5v6512 90 1 Evaluation evaluation NN cord-304472-mi5v6512 90 2 of of IN cord-304472-mi5v6512 90 3 safety safety NN cord-304472-mi5v6512 90 4 , , , cord-304472-mi5v6512 90 5 vaccine vaccine NN cord-304472-mi5v6512 90 6 viremia viremia NN cord-304472-mi5v6512 90 7 , , , cord-304472-mi5v6512 90 8 and and CC cord-304472-mi5v6512 90 9 neutralizing neutralize VBG cord-304472-mi5v6512 90 10 antibody antibody NN cord-304472-mi5v6512 90 11 response response NN cord-304472-mi5v6512 90 12 indicated indicate VBD cord-304472-mi5v6512 90 13 that that IN cord-304472-mi5v6512 90 14 a a DT cord-304472-mi5v6512 90 15 single single JJ cord-304472-mi5v6512 90 16 dose dose NN cord-304472-mi5v6512 90 17 is be VBZ cord-304472-mi5v6512 90 18 sufficient sufficient JJ cord-304472-mi5v6512 90 19 [ [ -LRB- cord-304472-mi5v6512 90 20 41 41 CD cord-304472-mi5v6512 90 21 ] ] -RRB- cord-304472-mi5v6512 90 22 . . . cord-304472-mi5v6512 91 1 Thus thus RB cord-304472-mi5v6512 91 2 , , , cord-304472-mi5v6512 91 3 this this DT cord-304472-mi5v6512 91 4 vaccine vaccine NN cord-304472-mi5v6512 91 5 has have VBZ cord-304472-mi5v6512 91 6 gone go VBN cord-304472-mi5v6512 91 7 into into IN cord-304472-mi5v6512 91 8 Phase phase NN cord-304472-mi5v6512 91 9 3 3 CD cord-304472-mi5v6512 91 10 trial trial NN cord-304472-mi5v6512 91 11 with with IN cord-304472-mi5v6512 91 12 a a DT cord-304472-mi5v6512 91 13 single single JJ cord-304472-mi5v6512 91 14 dose dose NN cord-304472-mi5v6512 91 15 ( ( -LRB- cord-304472-mi5v6512 91 16 in in IN cord-304472-mi5v6512 91 17 contrast contrast NN cord-304472-mi5v6512 91 18 to to IN cord-304472-mi5v6512 91 19 TAK-003 tak-003 NN cord-304472-mi5v6512 91 20 with with IN cord-304472-mi5v6512 91 21 2 2 CD cord-304472-mi5v6512 91 22 doses dose NNS cord-304472-mi5v6512 91 23 , , , cord-304472-mi5v6512 91 24 and and CC cord-304472-mi5v6512 91 25 CYD CYD NNP cord-304472-mi5v6512 91 26 - - HYPH cord-304472-mi5v6512 91 27 TDV TDV NNP cord-304472-mi5v6512 91 28 with with IN cord-304472-mi5v6512 91 29 3 3 CD cord-304472-mi5v6512 91 30 doses dose NNS cord-304472-mi5v6512 91 31 ) ) -RRB- cord-304472-mi5v6512 91 32 . . . cord-304472-mi5v6512 92 1 The the DT cord-304472-mi5v6512 92 2 Phase phase NN cord-304472-mi5v6512 92 3 3 3 CD cord-304472-mi5v6512 92 4 results result NNS cord-304472-mi5v6512 92 5 remain remain VBP cord-304472-mi5v6512 92 6 unpublished unpublished JJ cord-304472-mi5v6512 92 7 to to IN cord-304472-mi5v6512 92 8 date date NN cord-304472-mi5v6512 92 9 , , , cord-304472-mi5v6512 92 10 without without IN cord-304472-mi5v6512 92 11 known know VBN cord-304472-mi5v6512 92 12 interim interim JJ cord-304472-mi5v6512 92 13 analyses analysis NNS cord-304472-mi5v6512 92 14 . . . cord-304472-mi5v6512 93 1 Given give VBN cord-304472-mi5v6512 93 2 that that IN cord-304472-mi5v6512 93 3 many many JJ cord-304472-mi5v6512 93 4 endemic endemic JJ cord-304472-mi5v6512 93 5 countries country NNS cord-304472-mi5v6512 93 6 are be VBP cord-304472-mi5v6512 93 7 popular popular JJ cord-304472-mi5v6512 93 8 tourist tourist NN cord-304472-mi5v6512 93 9 destinations destination NNS cord-304472-mi5v6512 93 10 , , , cord-304472-mi5v6512 93 11 international international JJ cord-304472-mi5v6512 93 12 travelers traveler NNS cord-304472-mi5v6512 93 13 are be VBP cord-304472-mi5v6512 93 14 increasingly increasingly RB cord-304472-mi5v6512 93 15 at at IN cord-304472-mi5v6512 93 16 risk risk NN cord-304472-mi5v6512 93 17 of of IN cord-304472-mi5v6512 93 18 dengue dengue NN cord-304472-mi5v6512 93 19 [ [ -LRB- cord-304472-mi5v6512 93 20 5 5 CD cord-304472-mi5v6512 93 21 , , , cord-304472-mi5v6512 93 22 8 8 CD cord-304472-mi5v6512 93 23 , , , cord-304472-mi5v6512 93 24 [ [ -LRB- cord-304472-mi5v6512 93 25 10 10 CD cord-304472-mi5v6512 93 26 ] ] -RRB- cord-304472-mi5v6512 93 27 [ [ -LRB- cord-304472-mi5v6512 93 28 11 11 CD cord-304472-mi5v6512 93 29 ] ] -RRB- cord-304472-mi5v6512 93 30 [ [ -LRB- cord-304472-mi5v6512 93 31 12 12 CD cord-304472-mi5v6512 93 32 ] ] -RRB- cord-304472-mi5v6512 93 33 42 42 CD cord-304472-mi5v6512 93 34 ] ] -RRB- cord-304472-mi5v6512 93 35 , , , cord-304472-mi5v6512 93 36 with with IN cord-304472-mi5v6512 93 37 attack attack NN cord-304472-mi5v6512 93 38 rates rate NNS cord-304472-mi5v6512 93 39 reported report VBN cord-304472-mi5v6512 93 40 as as RB cord-304472-mi5v6512 93 41 high high JJ cord-304472-mi5v6512 93 42 as as IN cord-304472-mi5v6512 93 43 5.51 5.51 CD cord-304472-mi5v6512 93 44 cases case NNS cord-304472-mi5v6512 93 45 per per IN cord-304472-mi5v6512 93 46 1000 1000 CD cord-304472-mi5v6512 93 47 travel travel NN cord-304472-mi5v6512 93 48 - - HYPH cord-304472-mi5v6512 93 49 months month NNS cord-304472-mi5v6512 93 50 [ [ -LRB- cord-304472-mi5v6512 93 51 43 43 CD cord-304472-mi5v6512 93 52 ] ] -RRB- cord-304472-mi5v6512 93 53 . . . cord-304472-mi5v6512 94 1 Dengue dengue NN cord-304472-mi5v6512 94 2 is be VBZ cord-304472-mi5v6512 94 3 a a DT cord-304472-mi5v6512 94 4 frequent frequent JJ cord-304472-mi5v6512 94 5 problem problem NN cord-304472-mi5v6512 94 6 in in IN cord-304472-mi5v6512 94 7 travelers traveler NNS cord-304472-mi5v6512 94 8 [ [ -LRB- cord-304472-mi5v6512 94 9 44.45 44.45 CD cord-304472-mi5v6512 94 10 ] ] -RRB- cord-304472-mi5v6512 94 11 , , , cord-304472-mi5v6512 94 12 more more RBR cord-304472-mi5v6512 94 13 frequent frequent JJ cord-304472-mi5v6512 94 14 than than IN cord-304472-mi5v6512 94 15 ' ' `` cord-304472-mi5v6512 94 16 traditional traditional JJ cord-304472-mi5v6512 94 17 ' ' '' cord-304472-mi5v6512 94 18 travel travel NN cord-304472-mi5v6512 94 19 - - HYPH cord-304472-mi5v6512 94 20 associated associate VBN cord-304472-mi5v6512 94 21 infectious infectious JJ cord-304472-mi5v6512 94 22 diseases disease NNS cord-304472-mi5v6512 94 23 such such JJ cord-304472-mi5v6512 94 24 as as IN cord-304472-mi5v6512 94 25 typhoid typhoid NN cord-304472-mi5v6512 94 26 fever fever NN cord-304472-mi5v6512 94 27 [ [ -LRB- cord-304472-mi5v6512 94 28 46 46 CD cord-304472-mi5v6512 94 29 ] ] -RRB- cord-304472-mi5v6512 94 30 , , , cord-304472-mi5v6512 94 31 rabies rabie NNS cord-304472-mi5v6512 94 32 [ [ -LRB- cord-304472-mi5v6512 94 33 47 47 CD cord-304472-mi5v6512 94 34 ] ] -RRB- cord-304472-mi5v6512 94 35 , , , cord-304472-mi5v6512 94 36 and and CC cord-304472-mi5v6512 94 37 yellow yellow JJ cord-304472-mi5v6512 94 38 fever fever NN cord-304472-mi5v6512 94 39 [ [ -LRB- cord-304472-mi5v6512 94 40 48 48 CD cord-304472-mi5v6512 94 41 , , , cord-304472-mi5v6512 94 42 49 49 CD cord-304472-mi5v6512 94 43 ] ] -RRB- cord-304472-mi5v6512 94 44 . . . cord-304472-mi5v6512 95 1 GeoSentinel GeoSentinel NNP cord-304472-mi5v6512 95 2 is be VBZ cord-304472-mi5v6512 95 3 an an DT cord-304472-mi5v6512 95 4 international international JJ cord-304472-mi5v6512 95 5 network network NN cord-304472-mi5v6512 95 6 of of IN cord-304472-mi5v6512 95 7 travel travel NN cord-304472-mi5v6512 95 8 medicine medicine NN cord-304472-mi5v6512 95 9 providers provider NNS cord-304472-mi5v6512 95 10 to to TO cord-304472-mi5v6512 95 11 monitor monitor VB cord-304472-mi5v6512 95 12 trends trend NNS cord-304472-mi5v6512 95 13 in in IN cord-304472-mi5v6512 95 14 travel travel NN cord-304472-mi5v6512 95 15 - - HYPH cord-304472-mi5v6512 95 16 associated associate VBN cord-304472-mi5v6512 95 17 diseases disease NNS cord-304472-mi5v6512 95 18 [ [ -LRB- cord-304472-mi5v6512 95 19 50 50 CD cord-304472-mi5v6512 95 20 ] ] -RRB- cord-304472-mi5v6512 95 21 [ [ -LRB- cord-304472-mi5v6512 95 22 51 51 CD cord-304472-mi5v6512 95 23 ] ] -RRB- cord-304472-mi5v6512 95 24 [ [ -LRB- cord-304472-mi5v6512 95 25 52 52 CD cord-304472-mi5v6512 95 26 ] ] -RRB- cord-304472-mi5v6512 95 27 which which WDT cord-304472-mi5v6512 95 28 has have VBZ cord-304472-mi5v6512 95 29 reported report VBN cord-304472-mi5v6512 95 30 a a DT cord-304472-mi5v6512 95 31 substantial substantial JJ cord-304472-mi5v6512 95 32 increase increase NN cord-304472-mi5v6512 95 33 of of IN cord-304472-mi5v6512 95 34 dengue dengue NN cord-304472-mi5v6512 95 35 over over IN cord-304472-mi5v6512 95 36 the the DT cord-304472-mi5v6512 95 37 past past JJ cord-304472-mi5v6512 95 38 decade decade NN cord-304472-mi5v6512 95 39 [ [ -LRB- cord-304472-mi5v6512 95 40 53 53 CD cord-304472-mi5v6512 95 41 ] ] -RRB- cord-304472-mi5v6512 95 42 . . . cord-304472-mi5v6512 96 1 Dengue dengue NN cord-304472-mi5v6512 96 2 can can MD cord-304472-mi5v6512 96 3 affect affect VB cord-304472-mi5v6512 96 4 tourist tourist NN cord-304472-mi5v6512 96 5 travelers traveler NNS cord-304472-mi5v6512 96 6 , , , cord-304472-mi5v6512 96 7 business business NN cord-304472-mi5v6512 96 8 travelers traveler NNS cord-304472-mi5v6512 96 9 and and CC cord-304472-mi5v6512 96 10 expatriates expatriate NNS cord-304472-mi5v6512 96 11 [ [ -LRB- cord-304472-mi5v6512 96 12 12 12 CD cord-304472-mi5v6512 96 13 , , , cord-304472-mi5v6512 96 14 52 52 CD cord-304472-mi5v6512 96 15 ] ] -RRB- cord-304472-mi5v6512 96 16 , , , cord-304472-mi5v6512 96 17 migrants migrant NNS cord-304472-mi5v6512 96 18 including include VBG cord-304472-mi5v6512 96 19 those those DT cord-304472-mi5v6512 96 20 visiting visit VBG cord-304472-mi5v6512 96 21 friends friend NNS cord-304472-mi5v6512 96 22 and and CC cord-304472-mi5v6512 96 23 relatives relative NNS cord-304472-mi5v6512 96 24 ( ( -LRB- cord-304472-mi5v6512 96 25 VFR VFR NNP cord-304472-mi5v6512 96 26 ) ) -RRB- cord-304472-mi5v6512 96 27 [ [ -LRB- cord-304472-mi5v6512 96 28 54 54 CD cord-304472-mi5v6512 96 29 ] ] -RRB- cord-304472-mi5v6512 96 30 , , , cord-304472-mi5v6512 96 31 and and CC cord-304472-mi5v6512 96 32 pilgrims pilgrim NNS cord-304472-mi5v6512 96 33 [ [ -LRB- cord-304472-mi5v6512 96 34 55 55 CD cord-304472-mi5v6512 96 35 ] ] -RRB- cord-304472-mi5v6512 96 36 ; ; : cord-304472-mi5v6512 96 37 both both CC cord-304472-mi5v6512 96 38 in in IN cord-304472-mi5v6512 96 39 adult adult NN cord-304472-mi5v6512 96 40 and and CC cord-304472-mi5v6512 96 41 pediatric pediatric JJ cord-304472-mi5v6512 96 42 travelers traveler NNS cord-304472-mi5v6512 96 43 [ [ -LRB- cord-304472-mi5v6512 96 44 11 11 CD cord-304472-mi5v6512 96 45 , , , cord-304472-mi5v6512 96 46 42 42 CD cord-304472-mi5v6512 96 47 , , , cord-304472-mi5v6512 96 48 56 56 CD cord-304472-mi5v6512 96 49 ] ] -RRB- cord-304472-mi5v6512 96 50 . . . cord-304472-mi5v6512 97 1 Interruption interruption NN cord-304472-mi5v6512 97 2 of of IN cord-304472-mi5v6512 97 3 travel travel NN cord-304472-mi5v6512 97 4 , , , cord-304472-mi5v6512 97 5 hospitalization hospitalization NN cord-304472-mi5v6512 97 6 during during IN cord-304472-mi5v6512 97 7 or or CC cord-304472-mi5v6512 97 8 after after IN cord-304472-mi5v6512 97 9 travel travel NN cord-304472-mi5v6512 97 10 , , , cord-304472-mi5v6512 97 11 and and CC cord-304472-mi5v6512 97 12 out out RB cord-304472-mi5v6512 97 13 - - HYPH cord-304472-mi5v6512 97 14 of of IN cord-304472-mi5v6512 97 15 - - HYPH cord-304472-mi5v6512 97 16 pocket pocket NN cord-304472-mi5v6512 97 17 expenses expense NNS cord-304472-mi5v6512 97 18 can can MD cord-304472-mi5v6512 97 19 ensue ensue VB cord-304472-mi5v6512 97 20 [ [ -LRB- cord-304472-mi5v6512 97 21 9 9 CD cord-304472-mi5v6512 97 22 ] ] -RRB- cord-304472-mi5v6512 97 23 . . . cord-304472-mi5v6512 98 1 Dengue dengue NN cord-304472-mi5v6512 98 2 is be VBZ cord-304472-mi5v6512 98 3 now now RB cord-304472-mi5v6512 98 4 much much RB cord-304472-mi5v6512 98 5 more more RBR cord-304472-mi5v6512 98 6 frequent frequent JJ cord-304472-mi5v6512 98 7 than than IN cord-304472-mi5v6512 98 8 many many JJ cord-304472-mi5v6512 98 9 of of IN cord-304472-mi5v6512 98 10 the the DT cord-304472-mi5v6512 98 11 other other JJ cord-304472-mi5v6512 98 12 travel travel NN cord-304472-mi5v6512 98 13 - - HYPH cord-304472-mi5v6512 98 14 associated associate VBN cord-304472-mi5v6512 98 15 vaccine vaccine NN cord-304472-mi5v6512 98 16 preventable preventable JJ cord-304472-mi5v6512 98 17 diseases disease NNS cord-304472-mi5v6512 98 18 such such JJ cord-304472-mi5v6512 98 19 as as IN cord-304472-mi5v6512 98 20 rabies rabies NN cord-304472-mi5v6512 98 21 , , , cord-304472-mi5v6512 98 22 hepatitis hepatitis NNP cord-304472-mi5v6512 98 23 A A NNP cord-304472-mi5v6512 98 24 [ [ -LRB- cord-304472-mi5v6512 98 25 57 57 CD cord-304472-mi5v6512 98 26 ] ] -RRB- cord-304472-mi5v6512 98 27 , , , cord-304472-mi5v6512 98 28 yellow yellow JJ cord-304472-mi5v6512 98 29 fever fever NN cord-304472-mi5v6512 98 30 or or CC cord-304472-mi5v6512 98 31 Japanese japanese JJ cord-304472-mi5v6512 98 32 encephalitis encephalitis JJ cord-304472-mi5v6512 98 33 [ [ -LRB- cord-304472-mi5v6512 98 34 58 58 CD cord-304472-mi5v6512 98 35 , , , cord-304472-mi5v6512 98 36 59 59 CD cord-304472-mi5v6512 98 37 ] ] -RRB- cord-304472-mi5v6512 98 38 ; ; : cord-304472-mi5v6512 98 39 thus thus RB cord-304472-mi5v6512 98 40 , , , cord-304472-mi5v6512 98 41 vaccination vaccination NN cord-304472-mi5v6512 98 42 against against IN cord-304472-mi5v6512 98 43 dengue dengue NN cord-304472-mi5v6512 98 44 would would MD cord-304472-mi5v6512 98 45 be be VB cord-304472-mi5v6512 98 46 an an DT cord-304472-mi5v6512 98 47 indication indication NN cord-304472-mi5v6512 98 48 in in IN cord-304472-mi5v6512 98 49 the the DT cord-304472-mi5v6512 98 50 travel travel NN cord-304472-mi5v6512 98 51 medicine medicine NN cord-304472-mi5v6512 98 52 context context NN cord-304472-mi5v6512 98 53 . . . cord-304472-mi5v6512 99 1 The the DT cord-304472-mi5v6512 99 2 limitation limitation NN cord-304472-mi5v6512 99 3 of of IN cord-304472-mi5v6512 99 4 the the DT cord-304472-mi5v6512 99 5 currently currently RB cord-304472-mi5v6512 99 6 only only RB cord-304472-mi5v6512 99 7 licensed license VBN cord-304472-mi5v6512 99 8 dengue dengue NN cord-304472-mi5v6512 99 9 vaccine vaccine NN cord-304472-mi5v6512 99 10 , , , cord-304472-mi5v6512 99 11 CYD CYD NNP cord-304472-mi5v6512 99 12 - - HYPH cord-304472-mi5v6512 99 13 TDV TDV NNP cord-304472-mi5v6512 99 14 , , , cord-304472-mi5v6512 99 15 is be VBZ cord-304472-mi5v6512 99 16 that that IN cord-304472-mi5v6512 99 17 it -PRON- PRP cord-304472-mi5v6512 99 18 should should MD cord-304472-mi5v6512 99 19 only only RB cord-304472-mi5v6512 99 20 be be VB cord-304472-mi5v6512 99 21 used use VBN cord-304472-mi5v6512 99 22 in in IN cord-304472-mi5v6512 99 23 seropositive seropositive JJ cord-304472-mi5v6512 99 24 travelers traveler NNS cord-304472-mi5v6512 99 25 [ [ -LRB- cord-304472-mi5v6512 99 26 27 27 CD cord-304472-mi5v6512 99 27 ] ] -RRB- cord-304472-mi5v6512 99 28 . . . cord-304472-mi5v6512 100 1 However however RB cord-304472-mi5v6512 100 2 , , , cord-304472-mi5v6512 100 3 most most JJS cord-304472-mi5v6512 100 4 travelers traveler NNS cord-304472-mi5v6512 100 5 are be VBP cord-304472-mi5v6512 100 6 seronegative seronegative JJ cord-304472-mi5v6512 100 7 . . . cord-304472-mi5v6512 101 1 Furthermore furthermore RB cord-304472-mi5v6512 101 2 , , , cord-304472-mi5v6512 101 3 the the DT cord-304472-mi5v6512 101 4 dosing dosing NN cord-304472-mi5v6512 101 5 schedule schedule NN cord-304472-mi5v6512 101 6 of of IN cord-304472-mi5v6512 101 7 3 3 CD cord-304472-mi5v6512 101 8 doses dose NNS cord-304472-mi5v6512 101 9 6 6 CD cord-304472-mi5v6512 101 10 months month NNS cord-304472-mi5v6512 101 11 apart apart RB cord-304472-mi5v6512 101 12 for for IN cord-304472-mi5v6512 101 13 CYD CYD NNP cord-304472-mi5v6512 101 14 - - HYPH cord-304472-mi5v6512 101 15 TDV TDV NNP cord-304472-mi5v6512 101 16 renders render VBZ cord-304472-mi5v6512 101 17 the the DT cord-304472-mi5v6512 101 18 use use NN cord-304472-mi5v6512 101 19 of of IN cord-304472-mi5v6512 101 20 such such PDT cord-304472-mi5v6512 101 21 a a DT cord-304472-mi5v6512 101 22 vaccine vaccine NN cord-304472-mi5v6512 101 23 difficult difficult JJ cord-304472-mi5v6512 101 24 in in IN cord-304472-mi5v6512 101 25 the the DT cord-304472-mi5v6512 101 26 travel travel NN cord-304472-mi5v6512 101 27 medicine medicine NN cord-304472-mi5v6512 101 28 setting setting NN cord-304472-mi5v6512 101 29 . . . cord-304472-mi5v6512 102 1 A a DT cord-304472-mi5v6512 102 2 safe safe JJ cord-304472-mi5v6512 102 3 and and CC cord-304472-mi5v6512 102 4 efficacious efficacious JJ cord-304472-mi5v6512 102 5 vaccine vaccine NN cord-304472-mi5v6512 102 6 that that WDT cord-304472-mi5v6512 102 7 can can MD cord-304472-mi5v6512 102 8 be be VB cord-304472-mi5v6512 102 9 used use VBN cord-304472-mi5v6512 102 10 regardless regardless RB cord-304472-mi5v6512 102 11 of of IN cord-304472-mi5v6512 102 12 serostatus serostatus NN cord-304472-mi5v6512 102 13 is be VBZ cord-304472-mi5v6512 102 14 needed need VBN cord-304472-mi5v6512 102 15 for for IN cord-304472-mi5v6512 102 16 travelers traveler NNS cord-304472-mi5v6512 102 17 [ [ -LRB- cord-304472-mi5v6512 102 18 60 60 CD cord-304472-mi5v6512 102 19 ] ] -RRB- cord-304472-mi5v6512 102 20 . . . cord-304472-mi5v6512 103 1 Until until IN cord-304472-mi5v6512 103 2 a a DT cord-304472-mi5v6512 103 3 vaccine vaccine NN cord-304472-mi5v6512 103 4 becomes become VBZ cord-304472-mi5v6512 103 5 available available JJ cord-304472-mi5v6512 103 6 that that WDT cord-304472-mi5v6512 103 7 would would MD cord-304472-mi5v6512 103 8 benefit benefit VB cord-304472-mi5v6512 103 9 all all DT cord-304472-mi5v6512 103 10 travelers traveler NNS cord-304472-mi5v6512 103 11 to to IN cord-304472-mi5v6512 103 12 dengue dengue VB cord-304472-mi5v6512 103 13 endemic endemic JJ cord-304472-mi5v6512 103 14 countries country NNS cord-304472-mi5v6512 103 15 , , , cord-304472-mi5v6512 103 16 travelers traveler NNS cord-304472-mi5v6512 103 17 should should MD cord-304472-mi5v6512 103 18 be be VB cord-304472-mi5v6512 103 19 advised advise VBN cord-304472-mi5v6512 103 20 to to TO cord-304472-mi5v6512 103 21 take take VB cord-304472-mi5v6512 103 22 day day NN cord-304472-mi5v6512 103 23 - - HYPH cord-304472-mi5v6512 103 24 time time NN cord-304472-mi5v6512 103 25 personal personal JJ cord-304472-mi5v6512 103 26 protective protective JJ cord-304472-mi5v6512 103 27 measures measure NNS cord-304472-mi5v6512 103 28 against against IN cord-304472-mi5v6512 103 29 mosquito mosquito NN cord-304472-mi5v6512 103 30 bites bite NNS cord-304472-mi5v6512 103 31 [ [ -LRB- cord-304472-mi5v6512 103 32 61 61 CD cord-304472-mi5v6512 103 33 ] ] -RRB- cord-304472-mi5v6512 103 34 and and CC cord-304472-mi5v6512 103 35 consider consider VB cord-304472-mi5v6512 103 36 Dengvaxia Dengvaxia NNP cord-304472-mi5v6512 103 37 if if IN cord-304472-mi5v6512 103 38 they -PRON- PRP cord-304472-mi5v6512 103 39 are be VBP cord-304472-mi5v6512 103 40 seropositive seropositive JJ cord-304472-mi5v6512 103 41 [ [ -LRB- cord-304472-mi5v6512 103 42 28 28 CD cord-304472-mi5v6512 103 43 ] ] -RRB- cord-304472-mi5v6512 103 44 . . . cord-304472-mi5v6512 104 1 Pre pre JJ cord-304472-mi5v6512 104 2 - - JJ cord-304472-mi5v6512 104 3 travel travel JJ cord-304472-mi5v6512 104 4 advice advice NN cord-304472-mi5v6512 104 5 for for IN cord-304472-mi5v6512 104 6 all all DT cord-304472-mi5v6512 104 7 travellers traveller NNS cord-304472-mi5v6512 105 1 to to IN cord-304472-mi5v6512 105 2 dengue dengue VB cord-304472-mi5v6512 105 3 endemic endemic JJ cord-304472-mi5v6512 105 4 countries country NNS cord-304472-mi5v6512 105 5 need need VBP cord-304472-mi5v6512 105 6 to to TO cord-304472-mi5v6512 105 7 include include VB cord-304472-mi5v6512 105 8 advice advice NN cord-304472-mi5v6512 105 9 on on IN cord-304472-mi5v6512 105 10 the the DT cord-304472-mi5v6512 105 11 dengue dengue NN cord-304472-mi5v6512 105 12 risk risk NN cord-304472-mi5v6512 105 13 [ [ -LRB- cord-304472-mi5v6512 105 14 5 5 CD cord-304472-mi5v6512 105 15 , , , cord-304472-mi5v6512 105 16 62 62 CD cord-304472-mi5v6512 105 17 ] ] -RRB- cord-304472-mi5v6512 105 18 . . . cord-304472-mi5v6512 106 1 While while IN cord-304472-mi5v6512 106 2 dengue dengue NN cord-304472-mi5v6512 106 3 - - HYPH cord-304472-mi5v6512 106 4 primed prime VBN cord-304472-mi5v6512 106 5 individuals individual NNS cord-304472-mi5v6512 106 6 can can MD cord-304472-mi5v6512 106 7 already already RB cord-304472-mi5v6512 106 8 benefit benefit VB cord-304472-mi5v6512 106 9 from from IN cord-304472-mi5v6512 106 10 vaccination vaccination NN cord-304472-mi5v6512 106 11 against against IN cord-304472-mi5v6512 106 12 all all DT cord-304472-mi5v6512 106 13 four four CD cord-304472-mi5v6512 106 14 serotypes serotype NNS cord-304472-mi5v6512 106 15 with with IN cord-304472-mi5v6512 106 16 the the DT cord-304472-mi5v6512 106 17 first first JJ cord-304472-mi5v6512 106 18 licensed licensed JJ cord-304472-mi5v6512 106 19 dengue dengue NN cord-304472-mi5v6512 106 20 vaccine vaccine NN cord-304472-mi5v6512 106 21 CYD CYD NNP cord-304472-mi5v6512 106 22 - - HYPH cord-304472-mi5v6512 106 23 TDV TDV NNP cord-304472-mi5v6512 106 24 , , , cord-304472-mi5v6512 106 25 the the DT cord-304472-mi5v6512 106 26 need need NN cord-304472-mi5v6512 106 27 for for IN cord-304472-mi5v6512 106 28 dengue dengue NN cord-304472-mi5v6512 106 29 - - HYPH cord-304472-mi5v6512 106 30 naive naive JJ cord-304472-mi5v6512 106 31 population population NN cord-304472-mi5v6512 106 32 has have VBZ cord-304472-mi5v6512 106 33 not not RB cord-304472-mi5v6512 106 34 yet yet RB cord-304472-mi5v6512 106 35 been be VBN cord-304472-mi5v6512 106 36 met meet VBN cord-304472-mi5v6512 106 37 . . . cord-304472-mi5v6512 107 1 Would Would MD cord-304472-mi5v6512 107 2 sequential sequential JJ cord-304472-mi5v6512 107 3 immunization immunization NN cord-304472-mi5v6512 107 4 induce induce VB cord-304472-mi5v6512 107 5 stronger strong JJR cord-304472-mi5v6512 107 6 and and CC cord-304472-mi5v6512 107 7 broader broad JJR cord-304472-mi5v6512 107 8 immunity immunity NN cord-304472-mi5v6512 107 9 against against IN cord-304472-mi5v6512 107 10 four four CD cord-304472-mi5v6512 107 11 DENV DENV NNP cord-304472-mi5v6512 107 12 serotypes serotype NNS cord-304472-mi5v6512 107 13 than than IN cord-304472-mi5v6512 107 14 tetravalent tetravalent NN cord-304472-mi5v6512 107 15 - - HYPH cord-304472-mi5v6512 107 16 formulated formulate VBN cord-304472-mi5v6512 107 17 immunization immunization NN cord-304472-mi5v6512 107 18 and and CC cord-304472-mi5v6512 107 19 overcome overcome VB cord-304472-mi5v6512 107 20 the the DT cord-304472-mi5v6512 107 21 viral viral JJ cord-304472-mi5v6512 107 22 interference interference NN cord-304472-mi5v6512 107 23 we -PRON- PRP cord-304472-mi5v6512 107 24 have have VBP cord-304472-mi5v6512 107 25 seen see VBN cord-304472-mi5v6512 107 26 to to IN cord-304472-mi5v6512 107 27 date date NN cord-304472-mi5v6512 107 28 for for IN cord-304472-mi5v6512 107 29 the the DT cord-304472-mi5v6512 107 30 live live JJ cord-304472-mi5v6512 107 31 attenuated attenuated JJ cord-304472-mi5v6512 107 32 dengue dengue NN cord-304472-mi5v6512 107 33 vaccine vaccine NN cord-304472-mi5v6512 107 34 formulations formulation NNS cord-304472-mi5v6512 107 35 ? ? . cord-304472-mi5v6512 108 1 In in IN cord-304472-mi5v6512 108 2 a a DT cord-304472-mi5v6512 108 3 study study NN cord-304472-mi5v6512 108 4 in in IN cord-304472-mi5v6512 108 5 Singapore Singapore NNP cord-304472-mi5v6512 108 6 mice mouse NNS cord-304472-mi5v6512 108 7 were be VBD cord-304472-mi5v6512 108 8 immunized immunize VBN cord-304472-mi5v6512 108 9 with with IN cord-304472-mi5v6512 108 10 four four CD cord-304472-mi5v6512 108 11 DNA dna NN cord-304472-mi5v6512 108 12 plasmids plasmid NNS cord-304472-mi5v6512 108 13 , , , cord-304472-mi5v6512 108 14 each each DT cord-304472-mi5v6512 108 15 encoding encode VBG cord-304472-mi5v6512 108 16 the the DT cord-304472-mi5v6512 108 17 pre pre NN cord-304472-mi5v6512 108 18 - - NN cord-304472-mi5v6512 108 19 membrane membrane NN cord-304472-mi5v6512 108 20 and and CC cord-304472-mi5v6512 108 21 envelope envelope NN cord-304472-mi5v6512 108 22 from from IN cord-304472-mi5v6512 108 23 one one CD cord-304472-mi5v6512 108 24 DENV DENV NNP cord-304472-mi5v6512 108 25 serotype serotype NN cord-304472-mi5v6512 108 26 , , , cord-304472-mi5v6512 108 27 either either CC cord-304472-mi5v6512 108 28 sequentially sequentially RB cord-304472-mi5v6512 108 29 or or CC cord-304472-mi5v6512 108 30 simultaneously simultaneously RB cord-304472-mi5v6512 108 31 . . . cord-304472-mi5v6512 109 1 The the DT cord-304472-mi5v6512 109 2 sequential sequential JJ cord-304472-mi5v6512 109 3 immunization immunization NN cord-304472-mi5v6512 109 4 induced induce VBN cord-304472-mi5v6512 109 5 significantly significantly RB cord-304472-mi5v6512 109 6 higher high JJR cord-304472-mi5v6512 109 7 levels level NNS cord-304472-mi5v6512 109 8 of of IN cord-304472-mi5v6512 109 9 interferon interferon NN cord-304472-mi5v6512 109 10 ( ( -LRB- cord-304472-mi5v6512 109 11 IFN)g IFN)g NNP cord-304472-mi5v6512 109 12 - - HYPH cord-304472-mi5v6512 109 13 expressing express VBG cord-304472-mi5v6512 109 14 or or CC cord-304472-mi5v6512 109 15 tumor tumor NN cord-304472-mi5v6512 109 16 necrosis necrosis NN cord-304472-mi5v6512 109 17 factor factor NN cord-304472-mi5v6512 109 18 ( ( -LRB- cord-304472-mi5v6512 109 19 TNF)a TNF)a NNP cord-304472-mi5v6512 109 20 - - HYPH cord-304472-mi5v6512 109 21 expressing express VBG cord-304472-mi5v6512 109 22 CD4 CD4 NNP cord-304472-mi5v6512 109 23 + + CC cord-304472-mi5v6512 109 24 and and CC cord-304472-mi5v6512 109 25 CD8 CD8 NNP cord-304472-mi5v6512 109 26 + + CC cord-304472-mi5v6512 109 27 T T NNP cord-304472-mi5v6512 109 28 cells cell NNS cord-304472-mi5v6512 109 29 to to IN cord-304472-mi5v6512 109 30 both both DT cord-304472-mi5v6512 109 31 serotype serotype NN cord-304472-mi5v6512 109 32 - - HYPH cord-304472-mi5v6512 109 33 specific specific JJ cord-304472-mi5v6512 109 34 and and CC cord-304472-mi5v6512 109 35 conserved conserved JJ cord-304472-mi5v6512 109 36 epitopes epitope NNS cord-304472-mi5v6512 109 37 than than IN cord-304472-mi5v6512 109 38 tetravalent tetravalent NN cord-304472-mi5v6512 109 39 immunization immunization NN cord-304472-mi5v6512 109 40 [ [ -LRB- cord-304472-mi5v6512 109 41 63 63 CD cord-304472-mi5v6512 109 42 ] ] -RRB- cord-304472-mi5v6512 109 43 . . . cord-304472-mi5v6512 110 1 Moreover moreover RB cord-304472-mi5v6512 110 2 , , , cord-304472-mi5v6512 110 3 sequential sequential JJ cord-304472-mi5v6512 110 4 immunization immunization NN cord-304472-mi5v6512 110 5 induced induce VBN cord-304472-mi5v6512 110 6 higher high JJR cord-304472-mi5v6512 110 7 levels level NNS cord-304472-mi5v6512 110 8 of of IN cord-304472-mi5v6512 110 9 neutralizing neutralize VBG cord-304472-mi5v6512 110 10 antibodies antibody NNS cord-304472-mi5v6512 110 11 to to IN cord-304472-mi5v6512 110 12 all all DT cord-304472-mi5v6512 110 13 four four CD cord-304472-mi5v6512 110 14 DENV DENV NNP cord-304472-mi5v6512 110 15 serotypes serotype NNS cord-304472-mi5v6512 110 16 than than IN cord-304472-mi5v6512 110 17 tetravalent tetravalent NN cord-304472-mi5v6512 110 18 vaccination vaccination NN cord-304472-mi5v6512 110 19 . . . cord-304472-mi5v6512 111 1 In in IN cord-304472-mi5v6512 111 2 these these DT cord-304472-mi5v6512 111 3 animal animal NN cord-304472-mi5v6512 111 4 data datum NNS cord-304472-mi5v6512 111 5 , , , cord-304472-mi5v6512 111 6 sequential sequential JJ cord-304472-mi5v6512 111 7 immunization immunization NN cord-304472-mi5v6512 111 8 resulted result VBD cord-304472-mi5v6512 111 9 in in IN cord-304472-mi5v6512 111 10 more more RBR cord-304472-mi5v6512 111 11 diversified diversified JJ cord-304472-mi5v6512 111 12 immunoglobulin immunoglobulin NN cord-304472-mi5v6512 111 13 repertoire repertoire NN cord-304472-mi5v6512 111 14 , , , cord-304472-mi5v6512 111 15 and and CC cord-304472-mi5v6512 111 16 suggests suggest VBZ cord-304472-mi5v6512 111 17 that that IN cord-304472-mi5v6512 111 18 sequential sequential JJ cord-304472-mi5v6512 111 19 immunization immunization NN cord-304472-mi5v6512 111 20 offers offer VBZ cord-304472-mi5v6512 111 21 an an DT cord-304472-mi5v6512 111 22 alternative alternative JJ cord-304472-mi5v6512 111 23 approach approach NN cord-304472-mi5v6512 111 24 to to TO cord-304472-mi5v6512 111 25 potentially potentially RB cord-304472-mi5v6512 111 26 overcome overcome VB cord-304472-mi5v6512 111 27 the the DT cord-304472-mi5v6512 111 28 current current JJ cord-304472-mi5v6512 111 29 challenges challenge NNS cord-304472-mi5v6512 111 30 encountered encounter VBN cord-304472-mi5v6512 111 31 with with IN cord-304472-mi5v6512 111 32 tetravalent tetravalent NN cord-304472-mi5v6512 111 33 - - HYPH cord-304472-mi5v6512 111 34 formulated formulate VBN cord-304472-mi5v6512 111 35 dengue dengue NN cord-304472-mi5v6512 111 36 vaccines vaccine NNS cord-304472-mi5v6512 111 37 . . . cord-304472-mi5v6512 112 1 Another another DT cord-304472-mi5v6512 112 2 strategy strategy NN cord-304472-mi5v6512 112 3 to to TO cord-304472-mi5v6512 112 4 overcome overcome VB cord-304472-mi5v6512 112 5 viral viral JJ cord-304472-mi5v6512 112 6 interference interference NN cord-304472-mi5v6512 112 7 for for IN cord-304472-mi5v6512 112 8 tetravalent tetravalent NN cord-304472-mi5v6512 112 9 dengue dengue NN cord-304472-mi5v6512 112 10 vaccines vaccine NNS cord-304472-mi5v6512 112 11 would would MD cord-304472-mi5v6512 112 12 be be VB cord-304472-mi5v6512 112 13 to to TO cord-304472-mi5v6512 112 14 use use VB cord-304472-mi5v6512 112 15 a a DT cord-304472-mi5v6512 112 16 heterologous heterologous JJ cord-304472-mi5v6512 112 17 prime prime JJ cord-304472-mi5v6512 112 18 - - HYPH cord-304472-mi5v6512 112 19 boost boost NN cord-304472-mi5v6512 112 20 strategy strategy NN cord-304472-mi5v6512 112 21 . . . cord-304472-mi5v6512 113 1 While while IN cord-304472-mi5v6512 113 2 TAK-003 tak-003 DT cord-304472-mi5v6512 113 3 vaccine vaccine NN cord-304472-mi5v6512 113 4 induces induce VBZ cord-304472-mi5v6512 113 5 high high JJ cord-304472-mi5v6512 113 6 protection protection NN cord-304472-mi5v6512 113 7 against against IN cord-304472-mi5v6512 113 8 DENV2 denv2 NN cord-304472-mi5v6512 113 9 and and CC cord-304472-mi5v6512 113 10 to to IN cord-304472-mi5v6512 113 11 a a DT cord-304472-mi5v6512 113 12 lesser less JJR cord-304472-mi5v6512 113 13 extent extent NN cord-304472-mi5v6512 113 14 against against IN cord-304472-mi5v6512 113 15 DENV1 DENV1 NNS cord-304472-mi5v6512 113 16 in in IN cord-304472-mi5v6512 113 17 both both DT cord-304472-mi5v6512 113 18 dengue dengue NN cord-304472-mi5v6512 113 19 - - HYPH cord-304472-mi5v6512 113 20 seropositive seropositive JJ cord-304472-mi5v6512 113 21 and and CC cord-304472-mi5v6512 113 22 -seronegative -seronegative JJ cord-304472-mi5v6512 113 23 individuals individual NNS cord-304472-mi5v6512 113 24 , , , cord-304472-mi5v6512 113 25 CYD CYD NNP cord-304472-mi5v6512 113 26 - - HYPH cord-304472-mi5v6512 113 27 TDV TDV NNP cord-304472-mi5v6512 113 28 induces induce VBZ cord-304472-mi5v6512 113 29 a a DT cord-304472-mi5v6512 113 30 high high JJ cord-304472-mi5v6512 113 31 protection protection NN cord-304472-mi5v6512 113 32 against against IN cord-304472-mi5v6512 113 33 DENV3 DENV3 NNS cord-304472-mi5v6512 113 34 and and CC cord-304472-mi5v6512 113 35 4 4 CD cord-304472-mi5v6512 113 36 but but CC cord-304472-mi5v6512 113 37 to to IN cord-304472-mi5v6512 113 38 a a DT cord-304472-mi5v6512 113 39 lesser less JJR cord-304472-mi5v6512 113 40 extent extent NN cord-304472-mi5v6512 113 41 against against IN cord-304472-mi5v6512 113 42 DENV1 DENV1 NNS cord-304472-mi5v6512 113 43 and and CC cord-304472-mi5v6512 113 44 2 2 CD cord-304472-mi5v6512 113 45 . . . cord-304472-mi5v6512 114 1 Furthermore furthermore RB cord-304472-mi5v6512 114 2 , , , cord-304472-mi5v6512 114 3 while while IN cord-304472-mi5v6512 114 4 TAK-003 tak-003 DT cord-304472-mi5v6512 114 5 vaccine vaccine NN cord-304472-mi5v6512 114 6 performance performance NN cord-304472-mi5v6512 114 7 seems seem VBZ cord-304472-mi5v6512 114 8 to to TO cord-304472-mi5v6512 114 9 be be VB cord-304472-mi5v6512 114 10 less less JJR cord-304472-mi5v6512 114 11 serostatus serostatus NN cord-304472-mi5v6512 114 12 dependent dependent JJ cord-304472-mi5v6512 114 13 , , , cord-304472-mi5v6512 114 14 an an DT cord-304472-mi5v6512 114 15 inconclusive inconclusive JJ cord-304472-mi5v6512 114 16 relative relative JJ cord-304472-mi5v6512 114 17 risk risk NN cord-304472-mi5v6512 114 18 > > XX cord-304472-mi5v6512 115 1 1 1 CD cord-304472-mi5v6512 115 2 has have VBZ cord-304472-mi5v6512 115 3 been be VBN cord-304472-mi5v6512 115 4 observed observe VBN cord-304472-mi5v6512 115 5 for for IN cord-304472-mi5v6512 115 6 DENV3 DENV3 NNS cord-304472-mi5v6512 115 7 in in IN cord-304472-mi5v6512 115 8 seronegative seronegative JJ cord-304472-mi5v6512 115 9 vaccinees vaccinee NNS cord-304472-mi5v6512 115 10 and and CC cord-304472-mi5v6512 115 11 no no DT cord-304472-mi5v6512 115 12 conclusion conclusion NN cord-304472-mi5v6512 115 13 could could MD cord-304472-mi5v6512 115 14 be be VB cord-304472-mi5v6512 115 15 drawn draw VBN cord-304472-mi5v6512 115 16 regarding regard VBG cord-304472-mi5v6512 115 17 DENV4 DENV4 NNPS cord-304472-mi5v6512 115 18 [ [ -LRB- cord-304472-mi5v6512 115 19 30 30 CD cord-304472-mi5v6512 115 20 ] ] -RRB- cord-304472-mi5v6512 115 21 . . . cord-304472-mi5v6512 116 1 So so RB cord-304472-mi5v6512 116 2 what what WP cord-304472-mi5v6512 116 3 about about IN cord-304472-mi5v6512 116 4 combining combine VBG cord-304472-mi5v6512 116 5 both both DT cord-304472-mi5v6512 116 6 vaccines vaccine NNS cord-304472-mi5v6512 116 7 in in IN cord-304472-mi5v6512 116 8 a a DT cord-304472-mi5v6512 116 9 heterologous heterologous JJ cord-304472-mi5v6512 116 10 prime prime JJ cord-304472-mi5v6512 116 11 - - HYPH cord-304472-mi5v6512 116 12 boost boost NN cord-304472-mi5v6512 116 13 regimen regimen NN cord-304472-mi5v6512 116 14 , , , cord-304472-mi5v6512 116 15 leveraging leverage VBG cord-304472-mi5v6512 116 16 upon upon IN cord-304472-mi5v6512 116 17 the the DT cord-304472-mi5v6512 116 18 benefits benefit NNS cord-304472-mi5v6512 116 19 of of IN cord-304472-mi5v6512 116 20 each each DT cord-304472-mi5v6512 116 21 vaccine vaccine NN cord-304472-mi5v6512 116 22 and and CC cord-304472-mi5v6512 116 23 thereby thereby RB cord-304472-mi5v6512 116 24 minimizing minimize VBG cord-304472-mi5v6512 116 25 safety safety NN cord-304472-mi5v6512 116 26 concerns concern NNS cord-304472-mi5v6512 116 27 ? ? . cord-304472-mi5v6512 117 1 Priming prime VBG cord-304472-mi5v6512 117 2 with with IN cord-304472-mi5v6512 117 3 TAK-003 tak-003 NN cord-304472-mi5v6512 117 4 followed follow VBN cord-304472-mi5v6512 117 5 by by IN cord-304472-mi5v6512 117 6 a a DT cord-304472-mi5v6512 117 7 CYD CYD NNP cord-304472-mi5v6512 117 8 - - HYPH cord-304472-mi5v6512 117 9 TDV TDV NNP cord-304472-mi5v6512 117 10 boost boost NN cord-304472-mi5v6512 117 11 would would MD cord-304472-mi5v6512 117 12 initially initially RB cord-304472-mi5v6512 117 13 ensure ensure VB cord-304472-mi5v6512 117 14 strong strong JJ cord-304472-mi5v6512 117 15 humoral humoral JJ cord-304472-mi5v6512 117 16 and and CC cord-304472-mi5v6512 117 17 cellular cellular JJ cord-304472-mi5v6512 117 18 responses response NNS cord-304472-mi5v6512 117 19 against against IN cord-304472-mi5v6512 117 20 DENV2the denv2the DT cord-304472-mi5v6512 117 21 weakest weak JJS cord-304472-mi5v6512 117 22 CYD CYD NNP cord-304472-mi5v6512 117 23 - - HYPH cord-304472-mi5v6512 117 24 TDV TDV NNP cord-304472-mi5v6512 117 25 serotype serotype NN cord-304472-mi5v6512 117 26 - - : cord-304472-mi5v6512 117 27 , , , cord-304472-mi5v6512 117 28 and and CC cord-304472-mi5v6512 117 29 then then RB cord-304472-mi5v6512 117 30 eventually eventually RB cord-304472-mi5v6512 117 31 strengthen strengthen VB cord-304472-mi5v6512 117 32 responses response NNS cord-304472-mi5v6512 117 33 against against IN cord-304472-mi5v6512 117 34 the the DT cord-304472-mi5v6512 117 35 other other JJ cord-304472-mi5v6512 117 36 serotypes serotype NNS cord-304472-mi5v6512 117 37 , , , cord-304472-mi5v6512 117 38 in in IN cord-304472-mi5v6512 117 39 particular particular JJ cord-304472-mi5v6512 117 40 DENV4 denv4 XX cord-304472-mi5v6512 117 41 -the -the DT cord-304472-mi5v6512 117 42 dominant dominant JJ cord-304472-mi5v6512 117 43 CYD CYD NNP cord-304472-mi5v6512 117 44 - - HYPH cord-304472-mi5v6512 117 45 TDV TDV NNP cord-304472-mi5v6512 117 46 and and CC cord-304472-mi5v6512 117 47 weakest weak JJS cord-304472-mi5v6512 117 48 TAK-003 tak-003 NN cord-304472-mi5v6512 117 49 serotype serotype NN cord-304472-mi5v6512 117 50 [ [ -LRB- cord-304472-mi5v6512 117 51 64 64 CD cord-304472-mi5v6512 117 52 ] ] -RRB- cord-304472-mi5v6512 117 53 . . . cord-304472-mi5v6512 118 1 Heterologous Heterologous NNP cord-304472-mi5v6512 118 2 CYD CYD NNP cord-304472-mi5v6512 118 3 - - HYPH cord-304472-mi5v6512 118 4 TDV TDV NNP cord-304472-mi5v6512 118 5 boost boost NN cord-304472-mi5v6512 118 6 may may MD cord-304472-mi5v6512 118 7 also also RB cord-304472-mi5v6512 118 8 likely likely RB cord-304472-mi5v6512 118 9 induce induce VB cord-304472-mi5v6512 118 10 broader broad JJR cord-304472-mi5v6512 118 11 cross cross JJ cord-304472-mi5v6512 118 12 - - JJ cord-304472-mi5v6512 118 13 reactive reactive JJ cord-304472-mi5v6512 118 14 immune immune JJ cord-304472-mi5v6512 118 15 responses response NNS cord-304472-mi5v6512 118 16 at at IN cord-304472-mi5v6512 118 17 both both CC cord-304472-mi5v6512 118 18 humoral humoral JJ cord-304472-mi5v6512 118 19 and and CC cord-304472-mi5v6512 118 20 cellular cellular JJ cord-304472-mi5v6512 118 21 levels level NNS cord-304472-mi5v6512 118 22 . . . cord-304472-mi5v6512 119 1 Moreover moreover RB cord-304472-mi5v6512 119 2 , , , cord-304472-mi5v6512 119 3 CYD CYD NNP cord-304472-mi5v6512 119 4 - - HYPH cord-304472-mi5v6512 119 5 TDV TDV NNP cord-304472-mi5v6512 119 6 possesses possess VBZ cord-304472-mi5v6512 119 7 an an DT cord-304472-mi5v6512 119 8 YF-17D YF-17D NNP cord-304472-mi5v6512 119 9 backbone backbone NN cord-304472-mi5v6512 119 10 , , , cord-304472-mi5v6512 119 11 decreasing decrease VBG cord-304472-mi5v6512 119 12 the the DT cord-304472-mi5v6512 119 13 risk risk NN cord-304472-mi5v6512 119 14 of of IN cord-304472-mi5v6512 119 15 being be VBG cord-304472-mi5v6512 119 16 negatively negatively RB cord-304472-mi5v6512 119 17 impacted impact VBN cord-304472-mi5v6512 119 18 by by IN cord-304472-mi5v6512 119 19 initial initial JJ cord-304472-mi5v6512 119 20 TAK-003-induced TAK-003-induced NNP cord-304472-mi5v6512 119 21 DENV2-specific DENV2-specific NNP cord-304472-mi5v6512 119 22 cellular cellular JJ cord-304472-mi5v6512 119 23 responses response NNS cord-304472-mi5v6512 119 24 . . . cord-304472-mi5v6512 120 1 A a DT cord-304472-mi5v6512 120 2 DENV DENV NNP cord-304472-mi5v6512 120 3 1 1 CD cord-304472-mi5v6512 120 4 - - SYM cord-304472-mi5v6512 120 5 2 2 CD cord-304472-mi5v6512 120 6 dominant dominant JJ cord-304472-mi5v6512 120 7 vaccine vaccine NN cord-304472-mi5v6512 120 8 followed follow VBN cord-304472-mi5v6512 120 9 by by IN cord-304472-mi5v6512 120 10 a a DT cord-304472-mi5v6512 120 11 DENV3 denv3 NN cord-304472-mi5v6512 120 12 - - SYM cord-304472-mi5v6512 120 13 4 4 CD cord-304472-mi5v6512 120 14 dominant dominant JJ cord-304472-mi5v6512 120 15 vaccine vaccine NN cord-304472-mi5v6512 120 16 may may MD cord-304472-mi5v6512 120 17 also also RB cord-304472-mi5v6512 120 18 better well RBR cord-304472-mi5v6512 120 19 reflect reflect VB cord-304472-mi5v6512 120 20 the the DT cord-304472-mi5v6512 120 21 theoretical theoretical JJ cord-304472-mi5v6512 120 22 advantages advantage NNS cord-304472-mi5v6512 120 23 of of IN cord-304472-mi5v6512 120 24 sequential sequential JJ cord-304472-mi5v6512 120 25 infections infection NNS cord-304472-mi5v6512 120 26 as as IN cord-304472-mi5v6512 120 27 outlined outline VBN cord-304472-mi5v6512 120 28 above above RB cord-304472-mi5v6512 120 29 . . . cord-304472-mi5v6512 121 1 It -PRON- PRP cord-304472-mi5v6512 121 2 is be VBZ cord-304472-mi5v6512 121 3 likely likely JJ cord-304472-mi5v6512 121 4 that that IN cord-304472-mi5v6512 121 5 Takeda Takeda NNP cord-304472-mi5v6512 121 6 will will MD cord-304472-mi5v6512 121 7 only only RB cord-304472-mi5v6512 121 8 investigate investigate VB cord-304472-mi5v6512 121 9 such such PDT cord-304472-mi5v6512 121 10 a a DT cord-304472-mi5v6512 121 11 prime prime JJ cord-304472-mi5v6512 121 12 - - HYPH cord-304472-mi5v6512 121 13 boost boost NN cord-304472-mi5v6512 121 14 strategy strategy NN cord-304472-mi5v6512 121 15 after after IN cord-304472-mi5v6512 121 16 their -PRON- PRP$ cord-304472-mi5v6512 121 17 vaccine vaccine NN cord-304472-mi5v6512 121 18 has have VBZ cord-304472-mi5v6512 121 19 been be VBN cord-304472-mi5v6512 121 20 licensed license VBN cord-304472-mi5v6512 121 21 . . . cord-304472-mi5v6512 122 1 Combining combine VBG cord-304472-mi5v6512 122 2 vaccine vaccine NN cord-304472-mi5v6512 122 3 platforms platform NNS cord-304472-mi5v6512 122 4 developed develop VBN cord-304472-mi5v6512 122 5 by by IN cord-304472-mi5v6512 122 6 competing compete VBG cord-304472-mi5v6512 122 7 companies company NNS cord-304472-mi5v6512 122 8 may may MD cord-304472-mi5v6512 122 9 pose pose VB cord-304472-mi5v6512 122 10 challenges challenge NNS cord-304472-mi5v6512 122 11 , , , cord-304472-mi5v6512 122 12 but but CC cord-304472-mi5v6512 122 13 these these DT cord-304472-mi5v6512 122 14 can can MD cord-304472-mi5v6512 122 15 be be VB cord-304472-mi5v6512 122 16 overcome overcome VBN cord-304472-mi5v6512 122 17 . . . cord-304472-mi5v6512 123 1 Next next JJ cord-304472-mi5v6512 123 2 - - HYPH cord-304472-mi5v6512 123 3 generation generation NN cord-304472-mi5v6512 123 4 dengue dengue NN cord-304472-mi5v6512 123 5 vaccines vaccine NNS cord-304472-mi5v6512 123 6 in in IN cord-304472-mi5v6512 123 7 development development NN cord-304472-mi5v6512 123 8 include include VBP cord-304472-mi5v6512 123 9 DNA DNA NNP cord-304472-mi5v6512 123 10 , , , cord-304472-mi5v6512 123 11 subunit subunit NN cord-304472-mi5v6512 123 12 , , , cord-304472-mi5v6512 123 13 virus virus NN cord-304472-mi5v6512 123 14 - - HYPH cord-304472-mi5v6512 123 15 like like JJ cord-304472-mi5v6512 123 16 particles particle NNS cord-304472-mi5v6512 123 17 ( ( -LRB- cord-304472-mi5v6512 123 18 VLP VLP NNP cord-304472-mi5v6512 123 19 ) ) -RRB- cord-304472-mi5v6512 123 20 and and CC cord-304472-mi5v6512 123 21 viral viral JJ cord-304472-mi5v6512 123 22 vector vector NN cord-304472-mi5v6512 123 23 vaccines vaccine NNS cord-304472-mi5v6512 123 24 [ [ -LRB- cord-304472-mi5v6512 123 25 65 65 CD cord-304472-mi5v6512 123 26 ] ] -RRB- cord-304472-mi5v6512 123 27 . . . cord-304472-mi5v6512 124 1 Two two CD cord-304472-mi5v6512 124 2 phase phase NN cord-304472-mi5v6512 124 3 I -PRON- PRP cord-304472-mi5v6512 124 4 clinical clinical JJ cord-304472-mi5v6512 124 5 trials trial NNS cord-304472-mi5v6512 124 6 were be VBD cord-304472-mi5v6512 124 7 conducted conduct VBN cord-304472-mi5v6512 124 8 to to TO cord-304472-mi5v6512 124 9 evaluate evaluate VB cord-304472-mi5v6512 124 10 the the DT cord-304472-mi5v6512 124 11 safety safety NN cord-304472-mi5v6512 124 12 and and CC cord-304472-mi5v6512 124 13 efficacy efficacy NN cord-304472-mi5v6512 124 14 of of IN cord-304472-mi5v6512 124 15 the the DT cord-304472-mi5v6512 124 16 tetravalent tetravalent NN cord-304472-mi5v6512 124 17 formulation formulation NN cord-304472-mi5v6512 124 18 purified purify VBN cord-304472-mi5v6512 124 19 inactivated inactivated JJ cord-304472-mi5v6512 124 20 vaccine vaccine NN cord-304472-mi5v6512 124 21 combined combine VBN cord-304472-mi5v6512 124 22 with with IN cord-304472-mi5v6512 124 23 different different JJ cord-304472-mi5v6512 124 24 adjuvants adjuvant NNS cord-304472-mi5v6512 124 25 ( ( -LRB- cord-304472-mi5v6512 124 26 e.g. e.g. IN cord-304472-mi5v6512 124 27 aluminium aluminium NN cord-304472-mi5v6512 124 28 hydroxide hydroxide NN cord-304472-mi5v6512 124 29 , , , cord-304472-mi5v6512 124 30 AS01E as01e NN cord-304472-mi5v6512 124 31 or or CC cord-304472-mi5v6512 124 32 AS03B as03b LS cord-304472-mi5v6512 124 33 ) ) -RRB- cord-304472-mi5v6512 124 34 [ [ -LRB- cord-304472-mi5v6512 124 35 66 66 CD cord-304472-mi5v6512 124 36 , , , cord-304472-mi5v6512 124 37 67 67 CD cord-304472-mi5v6512 124 38 ] ] -RRB- cord-304472-mi5v6512 124 39 . . . cord-304472-mi5v6512 125 1 All all DT cord-304472-mi5v6512 125 2 formulations formulation NNS cord-304472-mi5v6512 125 3 were be VBD cord-304472-mi5v6512 125 4 well well RB cord-304472-mi5v6512 125 5 tolerated tolerate VBN cord-304472-mi5v6512 125 6 and and CC cord-304472-mi5v6512 125 7 induced induce VBD cord-304472-mi5v6512 125 8 a a DT cord-304472-mi5v6512 125 9 balanced balanced JJ cord-304472-mi5v6512 125 10 immune immune JJ cord-304472-mi5v6512 125 11 response response NN cord-304472-mi5v6512 125 12 against against IN cord-304472-mi5v6512 125 13 all all DT cord-304472-mi5v6512 125 14 four four CD cord-304472-mi5v6512 125 15 serotypes serotype NNS cord-304472-mi5v6512 125 16 , , , cord-304472-mi5v6512 125 17 with with IN cord-304472-mi5v6512 125 18 the the DT cord-304472-mi5v6512 125 19 highest high JJS cord-304472-mi5v6512 125 20 mean mean JJ cord-304472-mi5v6512 125 21 antibody antibody NN cord-304472-mi5v6512 125 22 titers titer NNS cord-304472-mi5v6512 125 23 reached reach VBD cord-304472-mi5v6512 125 24 with with IN cord-304472-mi5v6512 125 25 AS01E as01e NN cord-304472-mi5v6512 125 26 and and CC cord-304472-mi5v6512 125 27 AS03B. AS03B. NNP cord-304472-mi5v6512 125 28 A a DT cord-304472-mi5v6512 125 29 phase phase NN cord-304472-mi5v6512 125 30 2 2 CD cord-304472-mi5v6512 125 31 trial trial NN cord-304472-mi5v6512 125 32 is be VBZ cord-304472-mi5v6512 125 33 currently currently RB cord-304472-mi5v6512 125 34 evaluating evaluate VBG cord-304472-mi5v6512 125 35 a a DT cord-304472-mi5v6512 125 36 tetravalent tetravalent NN cord-304472-mi5v6512 125 37 purified purify VBN cord-304472-mi5v6512 125 38 inactivated inactivate VBN cord-304472-mi5v6512 125 39 dengue dengue NN cord-304472-mi5v6512 125 40 vaccine vaccine NN cord-304472-mi5v6512 125 41 with with IN cord-304472-mi5v6512 125 42 AS03B as03b NN cord-304472-mi5v6512 125 43 to to TO cord-304472-mi5v6512 125 44 determine determine VB cord-304472-mi5v6512 125 45 the the DT cord-304472-mi5v6512 125 46 most most RBS cord-304472-mi5v6512 125 47 effective effective JJ cord-304472-mi5v6512 125 48 injection injection NN cord-304472-mi5v6512 125 49 schedule schedule NN cord-304472-mi5v6512 125 50 ( ( -LRB- cord-304472-mi5v6512 125 51 0 0 CD cord-304472-mi5v6512 125 52 - - SYM cord-304472-mi5v6512 125 53 1 1 CD cord-304472-mi5v6512 125 54 , , , cord-304472-mi5v6512 125 55 0 0 CD cord-304472-mi5v6512 125 56 - - HYPH cord-304472-mi5v6512 125 57 1 1 CD cord-304472-mi5v6512 125 58 - - SYM cord-304472-mi5v6512 125 59 6 6 CD cord-304472-mi5v6512 125 60 , , , cord-304472-mi5v6512 125 61 or or CC cord-304472-mi5v6512 125 62 0 0 CD cord-304472-mi5v6512 125 63 - - SYM cord-304472-mi5v6512 125 64 3 3 CD cord-304472-mi5v6512 125 65 months month NNS cord-304472-mi5v6512 125 66 ) ) -RRB- cord-304472-mi5v6512 126 1 ( ( -LRB- cord-304472-mi5v6512 126 2 NCT02421367 nct02421367 NN cord-304472-mi5v6512 126 3 ) ) -RRB- cord-304472-mi5v6512 127 1 The the DT cord-304472-mi5v6512 127 2 emergence emergence NN cord-304472-mi5v6512 127 3 of of IN cord-304472-mi5v6512 127 4 Zika Zika NNP cord-304472-mi5v6512 127 5 virus virus NN cord-304472-mi5v6512 127 6 as as IN cord-304472-mi5v6512 127 7 a a DT cord-304472-mi5v6512 127 8 public public JJ cord-304472-mi5v6512 127 9 health health NN cord-304472-mi5v6512 127 10 problem problem NN cord-304472-mi5v6512 127 11 of of IN cord-304472-mi5v6512 127 12 international international JJ cord-304472-mi5v6512 127 13 concern concern NN cord-304472-mi5v6512 127 14 in in IN cord-304472-mi5v6512 127 15 early early JJ cord-304472-mi5v6512 127 16 2016 2016 CD cord-304472-mi5v6512 127 17 , , , cord-304472-mi5v6512 127 18 a a DT cord-304472-mi5v6512 127 19 vector vector NN cord-304472-mi5v6512 127 20 - - HYPH cord-304472-mi5v6512 127 21 borne bear VBN cord-304472-mi5v6512 127 22 virus virus NN cord-304472-mi5v6512 127 23 with with IN cord-304472-mi5v6512 127 24 close close JJ cord-304472-mi5v6512 127 25 genetic genetic JJ cord-304472-mi5v6512 127 26 similarity similarity NN cord-304472-mi5v6512 127 27 to to IN cord-304472-mi5v6512 127 28 dengue dengue NN cord-304472-mi5v6512 127 29 viruses virus NNS cord-304472-mi5v6512 127 30 , , , cord-304472-mi5v6512 127 31 was be VBD cord-304472-mi5v6512 127 32 the the DT cord-304472-mi5v6512 127 33 first first JJ cord-304472-mi5v6512 127 34 challenge challenge NN cord-304472-mi5v6512 127 35 to to IN cord-304472-mi5v6512 127 36 dengue dengue NN cord-304472-mi5v6512 127 37 vaccine vaccine NN cord-304472-mi5v6512 127 38 development development NN cord-304472-mi5v6512 127 39 , , , cord-304472-mi5v6512 127 40 followed follow VBN cord-304472-mi5v6512 127 41 by by IN cord-304472-mi5v6512 127 42 the the DT cord-304472-mi5v6512 127 43 emergence emergence NN cord-304472-mi5v6512 127 44 of of IN cord-304472-mi5v6512 127 45 another another DT cord-304472-mi5v6512 127 46 virus virus NN cord-304472-mi5v6512 127 47 by by IN cord-304472-mi5v6512 127 48 late late JJ cord-304472-mi5v6512 127 49 2019 2019 CD cord-304472-mi5v6512 127 50 , , , cord-304472-mi5v6512 127 51 not not RB cord-304472-mi5v6512 127 52 related relate VBN cord-304472-mi5v6512 127 53 to to IN cord-304472-mi5v6512 127 54 dengue dengue NN cord-304472-mi5v6512 127 55 , , . cord-304472-mi5v6512 128 1 SARS SARS NNP cord-304472-mi5v6512 128 2 - - HYPH cord-304472-mi5v6512 128 3 CoV-2 CoV-2 NNP cord-304472-mi5v6512 128 4 causing cause VBG cord-304472-mi5v6512 128 5 coronavirus coronavirus NN cord-304472-mi5v6512 128 6 related relate VBN cord-304472-mi5v6512 128 7 disease disease NN cord-304472-mi5v6512 128 8 ( ( -LRB- cord-304472-mi5v6512 128 9 COVID-19 COVID-19 NNP cord-304472-mi5v6512 128 10 ) ) -RRB- cord-304472-mi5v6512 128 11 . . . cord-304472-mi5v6512 129 1 Although although IN cord-304472-mi5v6512 129 2 dengue dengue NN cord-304472-mi5v6512 129 3 virus virus NN cord-304472-mi5v6512 129 4 is be VBZ cord-304472-mi5v6512 129 5 not not RB cord-304472-mi5v6512 129 6 associated associate VBN cord-304472-mi5v6512 129 7 with with IN cord-304472-mi5v6512 129 8 severe severe JJ cord-304472-mi5v6512 129 9 pregnancy pregnancy NN cord-304472-mi5v6512 129 10 outcomes outcome NNS cord-304472-mi5v6512 129 11 as as IN cord-304472-mi5v6512 129 12 Zika Zika NNP cord-304472-mi5v6512 129 13 [ [ -LRB- cord-304472-mi5v6512 129 14 68 68 CD cord-304472-mi5v6512 129 15 ] ] -RRB- cord-304472-mi5v6512 129 16 , , , cord-304472-mi5v6512 129 17 not not RB cord-304472-mi5v6512 129 18 thought think VBN cord-304472-mi5v6512 129 19 to to TO cord-304472-mi5v6512 129 20 be be VB cord-304472-mi5v6512 129 21 sexually sexually RB cord-304472-mi5v6512 129 22 transmitted transmit VBN cord-304472-mi5v6512 129 23 [ [ -LRB- cord-304472-mi5v6512 129 24 69 69 CD cord-304472-mi5v6512 129 25 , , , cord-304472-mi5v6512 129 26 70 70 CD cord-304472-mi5v6512 129 27 ] ] -RRB- cord-304472-mi5v6512 129 28 and and CC cord-304472-mi5v6512 129 29 not not RB cord-304472-mi5v6512 129 30 as as RB cord-304472-mi5v6512 129 31 strongly strongly RB cord-304472-mi5v6512 129 32 associated associate VBN cord-304472-mi5v6512 129 33 with with IN cord-304472-mi5v6512 129 34 neurological neurological JJ cord-304472-mi5v6512 129 35 complications complication NNS cord-304472-mi5v6512 129 36 such such JJ cord-304472-mi5v6512 129 37 as as IN cord-304472-mi5v6512 129 38 Guillain Guillain NNP cord-304472-mi5v6512 129 39 - - HYPH cord-304472-mi5v6512 129 40 Barre Barre NNP cord-304472-mi5v6512 129 41 Syndrome Syndrome NNP cord-304472-mi5v6512 129 42 [ [ -LRB- cord-304472-mi5v6512 129 43 71 71 CD cord-304472-mi5v6512 129 44 ] ] -RRB- cord-304472-mi5v6512 129 45 , , . cord-304472-mi5v6512 130 1 the the DT cord-304472-mi5v6512 130 2 emergence emergence NN cord-304472-mi5v6512 130 3 of of IN cord-304472-mi5v6512 130 4 Zika Zika NNP cord-304472-mi5v6512 130 5 has have VBZ cord-304472-mi5v6512 130 6 complicated complicate VBN cord-304472-mi5v6512 130 7 dengue dengue NN cord-304472-mi5v6512 130 8 vaccine vaccine NN cord-304472-mi5v6512 130 9 development development NN cord-304472-mi5v6512 130 10 because because IN cord-304472-mi5v6512 130 11 of of IN cord-304472-mi5v6512 130 12 the the DT cord-304472-mi5v6512 130 13 potential potential JJ cord-304472-mi5v6512 130 14 immunological immunological JJ cord-304472-mi5v6512 130 15 interaction interaction NN cord-304472-mi5v6512 130 16 between between IN cord-304472-mi5v6512 130 17 these these DT cord-304472-mi5v6512 130 18 closely closely RB cord-304472-mi5v6512 130 19 related related JJ cord-304472-mi5v6512 130 20 viruses virus NNS cord-304472-mi5v6512 130 21 . . . cord-304472-mi5v6512 131 1 By by IN cord-304472-mi5v6512 131 2 acquiring acquire VBG cord-304472-mi5v6512 131 3 cytotoxic cytotoxic JJ cord-304472-mi5v6512 131 4 T t NN cord-304472-mi5v6512 131 5 - - HYPH cord-304472-mi5v6512 131 6 cell cell NN cord-304472-mi5v6512 131 7 epitope epitope NN cord-304472-mi5v6512 131 8 - - HYPH cord-304472-mi5v6512 131 9 rich rich JJ cord-304472-mi5v6512 131 10 regions region NNS cord-304472-mi5v6512 131 11 from from IN cord-304472-mi5v6512 131 12 Culex Culex NNP cord-304472-mi5v6512 131 13 - - HYPH cord-304472-mi5v6512 131 14 borne bear VBN cord-304472-mi5v6512 131 15 flaviviruses flavivirus NNS cord-304472-mi5v6512 131 16 , , , cord-304472-mi5v6512 131 17 ZIKV ZIKV NNP cord-304472-mi5v6512 131 18 evaded evade VBD cord-304472-mi5v6512 131 19 DENV DENV NNP cord-304472-mi5v6512 131 20 - - HYPH cord-304472-mi5v6512 131 21 generated generate VBN cord-304472-mi5v6512 131 22 T t NN cord-304472-mi5v6512 131 23 - - HYPH cord-304472-mi5v6512 131 24 cell cell NN cord-304472-mi5v6512 131 25 immune immune JJ cord-304472-mi5v6512 131 26 cross cross NN cord-304472-mi5v6512 131 27 - - NN cord-304472-mi5v6512 131 28 protection protection JJ cord-304472-mi5v6512 131 29 [ [ -LRB- cord-304472-mi5v6512 131 30 72 72 CD cord-304472-mi5v6512 131 31 ] ] -RRB- cord-304472-mi5v6512 131 32 . . . cord-304472-mi5v6512 132 1 Interestingly interestingly RB cord-304472-mi5v6512 132 2 , , , cord-304472-mi5v6512 132 3 pre pre JJ cord-304472-mi5v6512 132 4 - - JJ cord-304472-mi5v6512 132 5 existing existing JJ cord-304472-mi5v6512 132 6 dengue dengue NN cord-304472-mi5v6512 132 7 immunity immunity NN cord-304472-mi5v6512 132 8 has have VBZ cord-304472-mi5v6512 132 9 minimal minimal JJ cord-304472-mi5v6512 132 10 impact impact NN cord-304472-mi5v6512 132 11 on on IN cord-304472-mi5v6512 132 12 the the DT cord-304472-mi5v6512 132 13 innate innate JJ cord-304472-mi5v6512 132 14 immune immune JJ cord-304472-mi5v6512 132 15 response response NN cord-304472-mi5v6512 132 16 to to IN cord-304472-mi5v6512 132 17 Zika Zika NNP cord-304472-mi5v6512 132 18 [ [ -LRB- cord-304472-mi5v6512 132 19 73 73 CD cord-304472-mi5v6512 132 20 ] ] -RRB- cord-304472-mi5v6512 132 21 . . . cord-304472-mi5v6512 133 1 Primary primary JJ cord-304472-mi5v6512 133 2 and and CC cord-304472-mi5v6512 133 3 secondary secondary JJ cord-304472-mi5v6512 133 4 DENV DENV NNP cord-304472-mi5v6512 133 5 elicit elicit VBP cord-304472-mi5v6512 133 6 similar similar JJ cord-304472-mi5v6512 133 7 memory memory NN cord-304472-mi5v6512 133 8 B b NN cord-304472-mi5v6512 133 9 - - HYPH cord-304472-mi5v6512 133 10 Cell cell NN cord-304472-mi5v6512 133 11 responses response NNS cord-304472-mi5v6512 133 12 , , , cord-304472-mi5v6512 133 13 but but CC cord-304472-mi5v6512 133 14 breadth breadth NN cord-304472-mi5v6512 133 15 to to IN cord-304472-mi5v6512 133 16 other other JJ cord-304472-mi5v6512 133 17 serotypes serotype NNS cord-304472-mi5v6512 133 18 and and CC cord-304472-mi5v6512 133 19 cross cross NN cord-304472-mi5v6512 133 20 - - NN cord-304472-mi5v6512 133 21 reactivity reactivity NN cord-304472-mi5v6512 133 22 to to IN cord-304472-mi5v6512 133 23 Zika Zika NNP cord-304472-mi5v6512 133 24 virus virus NN cord-304472-mi5v6512 133 25 is be VBZ cord-304472-mi5v6512 133 26 higher high JJR cord-304472-mi5v6512 133 27 in in IN cord-304472-mi5v6512 133 28 secondary secondary JJ cord-304472-mi5v6512 133 29 dengue dengue NN cord-304472-mi5v6512 133 30 [ [ -LRB- cord-304472-mi5v6512 133 31 74 74 CD cord-304472-mi5v6512 133 32 ] ] -RRB- cord-304472-mi5v6512 133 33 . . . cord-304472-mi5v6512 134 1 Immunity immunity NN cord-304472-mi5v6512 134 2 to to IN cord-304472-mi5v6512 134 3 DENV DENV NNP cord-304472-mi5v6512 134 4 only only RB cord-304472-mi5v6512 134 5 modestly modestly RB cord-304472-mi5v6512 134 6 shapes shape VBZ cord-304472-mi5v6512 134 7 breadth breadth NN cord-304472-mi5v6512 134 8 and and CC cord-304472-mi5v6512 134 9 magnitude magnitude NN cord-304472-mi5v6512 134 10 of of IN cord-304472-mi5v6512 134 11 enduring endure VBG cord-304472-mi5v6512 134 12 ZIKV ZIKV NNP cord-304472-mi5v6512 134 13 antibody antibody NN cord-304472-mi5v6512 134 14 responses response NNS cord-304472-mi5v6512 134 15 [ [ -LRB- cord-304472-mi5v6512 134 16 75 75 CD cord-304472-mi5v6512 134 17 ] ] -RRB- cord-304472-mi5v6512 134 18 . . . cord-304472-mi5v6512 135 1 While while IN cord-304472-mi5v6512 135 2 the the DT cord-304472-mi5v6512 135 3 evidence evidence NN cord-304472-mi5v6512 135 4 is be VBZ cord-304472-mi5v6512 135 5 mounting mount VBG cord-304472-mi5v6512 135 6 that that IN cord-304472-mi5v6512 135 7 preexisting preexist VBG cord-304472-mi5v6512 135 8 high high JJ cord-304472-mi5v6512 135 9 antibody antibody NN cord-304472-mi5v6512 135 10 titers titer NNS cord-304472-mi5v6512 135 11 to to IN cord-304472-mi5v6512 135 12 dengue dengue NN cord-304472-mi5v6512 135 13 virus virus NN cord-304472-mi5v6512 135 14 were be VBD cord-304472-mi5v6512 135 15 associated associate VBN cord-304472-mi5v6512 135 16 with with IN cord-304472-mi5v6512 135 17 reduced reduced JJ cord-304472-mi5v6512 135 18 risk risk NN cord-304472-mi5v6512 135 19 of of IN cord-304472-mi5v6512 135 20 ZIKV ZIKV NNP cord-304472-mi5v6512 135 21 infection infection NN cord-304472-mi5v6512 135 22 and and CC cord-304472-mi5v6512 135 23 symptoms symptom NNS cord-304472-mi5v6512 135 24 [ [ -LRB- cord-304472-mi5v6512 135 25 76 76 CD cord-304472-mi5v6512 135 26 ] ] -RRB- cord-304472-mi5v6512 135 27 , , , cord-304472-mi5v6512 135 28 there there EX cord-304472-mi5v6512 135 29 is be VBZ cord-304472-mi5v6512 135 30 still still RB cord-304472-mi5v6512 135 31 lack lack NN cord-304472-mi5v6512 135 32 of of IN cord-304472-mi5v6512 135 33 data datum NNS cord-304472-mi5v6512 135 34 on on IN cord-304472-mi5v6512 135 35 whether whether IN cord-304472-mi5v6512 135 36 pre pre JJ cord-304472-mi5v6512 135 37 - - JJ cord-304472-mi5v6512 135 38 existing existing JJ cord-304472-mi5v6512 135 39 immunity immunity NN cord-304472-mi5v6512 135 40 to to IN cord-304472-mi5v6512 135 41 Zika Zika NNP cord-304472-mi5v6512 135 42 protects protect VBZ cord-304472-mi5v6512 135 43 against against IN cord-304472-mi5v6512 135 44 or or CC cord-304472-mi5v6512 135 45 enhances enhance VBZ cord-304472-mi5v6512 135 46 a a DT cord-304472-mi5v6512 135 47 subsequent subsequent JJ cord-304472-mi5v6512 135 48 dengue dengue NN cord-304472-mi5v6512 135 49 infection infection NN cord-304472-mi5v6512 135 50 . . . cord-304472-mi5v6512 136 1 These these DT cord-304472-mi5v6512 136 2 are be VBP cord-304472-mi5v6512 136 3 data datum NNS cord-304472-mi5v6512 136 4 gaps gap NNS cord-304472-mi5v6512 136 5 that that WDT cord-304472-mi5v6512 136 6 need need VBP cord-304472-mi5v6512 136 7 to to TO cord-304472-mi5v6512 136 8 be be VB cord-304472-mi5v6512 136 9 addressed address VBN cord-304472-mi5v6512 136 10 for for IN cord-304472-mi5v6512 136 11 dengue dengue NN cord-304472-mi5v6512 136 12 vaccine vaccine NN cord-304472-mi5v6512 136 13 development development NN cord-304472-mi5v6512 136 14 . . . cord-304472-mi5v6512 137 1 Clearly clearly RB cord-304472-mi5v6512 137 2 , , , cord-304472-mi5v6512 137 3 the the DT cord-304472-mi5v6512 137 4 presence presence NN cord-304472-mi5v6512 137 5 of of IN cord-304472-mi5v6512 137 6 co co JJ cord-304472-mi5v6512 137 7 - - JJ cord-304472-mi5v6512 137 8 circulating circulating JJ cord-304472-mi5v6512 137 9 arboviruses arbovirus NNS cord-304472-mi5v6512 137 10 such such JJ cord-304472-mi5v6512 137 11 as as IN cord-304472-mi5v6512 137 12 dengue dengue NN cord-304472-mi5v6512 137 13 and and CC cord-304472-mi5v6512 137 14 Zika Zika NNP cord-304472-mi5v6512 137 15 increases increase VBZ cord-304472-mi5v6512 137 16 the the DT cord-304472-mi5v6512 137 17 chance chance NN cord-304472-mi5v6512 137 18 of of IN cord-304472-mi5v6512 137 19 co co NN cord-304472-mi5v6512 137 20 - - NN cord-304472-mi5v6512 137 21 infection infection NN cord-304472-mi5v6512 137 22 and and CC cord-304472-mi5v6512 137 23 demonstrates demonstrate VBZ cord-304472-mi5v6512 137 24 the the DT cord-304472-mi5v6512 137 25 importance importance NN cord-304472-mi5v6512 137 26 of of IN cord-304472-mi5v6512 137 27 the the DT cord-304472-mi5v6512 137 28 differential differential JJ cord-304472-mi5v6512 137 29 diagnosis diagnosis NN cord-304472-mi5v6512 137 30 , , , cord-304472-mi5v6512 137 31 especially especially RB cord-304472-mi5v6512 137 32 during during IN cord-304472-mi5v6512 137 33 periods period NNS cord-304472-mi5v6512 137 34 of of IN cord-304472-mi5v6512 137 35 arboviral arboviral JJ cord-304472-mi5v6512 137 36 outbreaks outbreak NNS cord-304472-mi5v6512 137 37 [ [ -LRB- cord-304472-mi5v6512 137 38 77 77 CD cord-304472-mi5v6512 137 39 ] ] -RRB- cord-304472-mi5v6512 137 40 , , , cord-304472-mi5v6512 137 41 and and CC cord-304472-mi5v6512 137 42 this this DT cord-304472-mi5v6512 137 43 needs need VBZ cord-304472-mi5v6512 137 44 to to TO cord-304472-mi5v6512 137 45 be be VB cord-304472-mi5v6512 137 46 taken take VBN cord-304472-mi5v6512 137 47 into into IN cord-304472-mi5v6512 137 48 consideration consideration NN cord-304472-mi5v6512 137 49 for for IN cord-304472-mi5v6512 137 50 clinical clinical JJ cord-304472-mi5v6512 137 51 trial trial NN cord-304472-mi5v6512 137 52 design design NN cord-304472-mi5v6512 137 53 . . . cord-304472-mi5v6512 138 1 The the DT cord-304472-mi5v6512 138 2 current current JJ cord-304472-mi5v6512 138 3 COVID-19 covid-19 JJ cord-304472-mi5v6512 138 4 pandemic pandemic NN cord-304472-mi5v6512 138 5 has have VBZ cord-304472-mi5v6512 138 6 placed place VBN cord-304472-mi5v6512 138 7 immense immense JJ cord-304472-mi5v6512 138 8 pressure pressure NN cord-304472-mi5v6512 138 9 on on IN cord-304472-mi5v6512 138 10 health health NN cord-304472-mi5v6512 138 11 care care NN cord-304472-mi5v6512 138 12 and and CC cord-304472-mi5v6512 138 13 public public JJ cord-304472-mi5v6512 138 14 health health NN cord-304472-mi5v6512 138 15 systems system NNS cord-304472-mi5v6512 138 16 worldwide worldwide RB cord-304472-mi5v6512 138 17 . . . cord-304472-mi5v6512 139 1 COVID-19 COVID-19 NNP cord-304472-mi5v6512 139 2 and and CC cord-304472-mi5v6512 139 3 dengue dengue NN cord-304472-mi5v6512 139 4 co co NNS cord-304472-mi5v6512 139 5 - - NNS cord-304472-mi5v6512 139 6 infections infection NNS cord-304472-mi5v6512 139 7 have have VBP cord-304472-mi5v6512 139 8 been be VBN cord-304472-mi5v6512 139 9 reported report VBN cord-304472-mi5v6512 139 10 [ [ -LRB- cord-304472-mi5v6512 139 11 78 78 CD cord-304472-mi5v6512 139 12 ] ] -RRB- cord-304472-mi5v6512 139 13 . . . cord-304472-mi5v6512 140 1 The the DT cord-304472-mi5v6512 140 2 response response NN cord-304472-mi5v6512 140 3 to to IN cord-304472-mi5v6512 140 4 this this DT cord-304472-mi5v6512 140 5 pandemic pandemic NN cord-304472-mi5v6512 140 6 unfortunately unfortunately RB cord-304472-mi5v6512 140 7 has have VBZ cord-304472-mi5v6512 140 8 diverted divert VBN cord-304472-mi5v6512 140 9 resources resource NNS cord-304472-mi5v6512 140 10 and and CC cord-304472-mi5v6512 140 11 finances finance NNS cord-304472-mi5v6512 140 12 ; ; : cord-304472-mi5v6512 140 13 and and CC cord-304472-mi5v6512 140 14 pushed push VBD cord-304472-mi5v6512 140 15 dengue dengue NN cord-304472-mi5v6512 140 16 vaccine vaccine NN cord-304472-mi5v6512 140 17 development development NN cord-304472-mi5v6512 140 18 out out IN cord-304472-mi5v6512 140 19 of of IN cord-304472-mi5v6512 140 20 the the DT cord-304472-mi5v6512 140 21 international international JJ cord-304472-mi5v6512 140 22 spotlight spotlight NN cord-304472-mi5v6512 140 23 . . . cord-304472-mi5v6512 141 1 A a DT cord-304472-mi5v6512 141 2 resurgence resurgence NN cord-304472-mi5v6512 141 3 of of IN cord-304472-mi5v6512 141 4 dengue dengue NN cord-304472-mi5v6512 141 5 is be VBZ cord-304472-mi5v6512 141 6 a a DT cord-304472-mi5v6512 141 7 real real JJ cord-304472-mi5v6512 141 8 threat threat NN cord-304472-mi5v6512 141 9 during during IN cord-304472-mi5v6512 141 10 the the DT cord-304472-mi5v6512 141 11 COVID-19 covid-19 JJ cord-304472-mi5v6512 141 12 pandemic pandemic NN cord-304472-mi5v6512 141 13 because because IN cord-304472-mi5v6512 141 14 the the DT cord-304472-mi5v6512 141 15 high high JJ cord-304472-mi5v6512 141 16 burden burden NN cord-304472-mi5v6512 141 17 of of IN cord-304472-mi5v6512 141 18 dengue dengue NN cord-304472-mi5v6512 141 19 related relate VBN cord-304472-mi5v6512 141 20 hospitalizations hospitalization NNS cord-304472-mi5v6512 141 21 will will MD cord-304472-mi5v6512 141 22 further further RB cord-304472-mi5v6512 141 23 overwhelm overwhelm VB cord-304472-mi5v6512 141 24 already already RB cord-304472-mi5v6512 141 25 overwhelmed overwhelm VBN cord-304472-mi5v6512 141 26 healthcare healthcare NN cord-304472-mi5v6512 141 27 systems system NNS cord-304472-mi5v6512 141 28 [ [ -LRB- cord-304472-mi5v6512 141 29 79 79 CD cord-304472-mi5v6512 141 30 ] ] -RRB- cord-304472-mi5v6512 141 31 . . . cord-304472-mi5v6512 142 1 The the DT cord-304472-mi5v6512 142 2 COVID-19 covid-19 CD cord-304472-mi5v6512 142 3 pandemic pandemic NN cord-304472-mi5v6512 142 4 therefore therefore RB cord-304472-mi5v6512 142 5 provides provide VBZ cord-304472-mi5v6512 142 6 even even RB cord-304472-mi5v6512 142 7 more more JJR cord-304472-mi5v6512 142 8 impetus impetus NN cord-304472-mi5v6512 142 9 to to TO cord-304472-mi5v6512 142 10 develop develop VB cord-304472-mi5v6512 142 11 , , , cord-304472-mi5v6512 142 12 license license VB cord-304472-mi5v6512 142 13 and and CC cord-304472-mi5v6512 142 14 roll roll VB cord-304472-mi5v6512 142 15 out out RP cord-304472-mi5v6512 142 16 dengue dengue NN cord-304472-mi5v6512 142 17 vaccines vaccine NNS cord-304472-mi5v6512 142 18 for for IN cord-304472-mi5v6512 142 19 broader broad JJR cord-304472-mi5v6512 142 20 use use NN cord-304472-mi5v6512 142 21 . . . cord-304472-mi5v6512 143 1 The the DT cord-304472-mi5v6512 143 2 first first JJ cord-304472-mi5v6512 143 3 licensed licensed JJ cord-304472-mi5v6512 143 4 dengue dengue NN cord-304472-mi5v6512 143 5 vaccine vaccine NN cord-304472-mi5v6512 143 6 led lead VBD cord-304472-mi5v6512 143 7 to to IN cord-304472-mi5v6512 143 8 considerable considerable JJ cord-304472-mi5v6512 143 9 controversy controversy NN cord-304472-mi5v6512 143 10 , , , cord-304472-mi5v6512 143 11 and and CC cord-304472-mi5v6512 143 12 to to IN cord-304472-mi5v6512 143 13 date date NN cord-304472-mi5v6512 143 14 , , , cord-304472-mi5v6512 143 15 no no DT cord-304472-mi5v6512 143 16 dengue dengue NN cord-304472-mi5v6512 143 17 vaccine vaccine NN cord-304472-mi5v6512 143 18 is be VBZ cord-304472-mi5v6512 143 19 in in IN cord-304472-mi5v6512 143 20 widespread widespread JJ cord-304472-mi5v6512 143 21 use use NN cord-304472-mi5v6512 143 22 . . . cord-304472-mi5v6512 144 1 All all DT cord-304472-mi5v6512 144 2 three three CD cord-304472-mi5v6512 144 3 leading lead VBG cord-304472-mi5v6512 144 4 dengue dengue NN cord-304472-mi5v6512 144 5 vaccine vaccine NN cord-304472-mi5v6512 144 6 candidates candidate NNS cord-304472-mi5v6512 144 7 are be VBP cord-304472-mi5v6512 144 8 live live RB cord-304472-mi5v6512 144 9 - - HYPH cord-304472-mi5v6512 144 10 attenuated attenuate VBN cord-304472-mi5v6512 144 11 vaccines vaccine NNS cord-304472-mi5v6512 144 12 , , , cord-304472-mi5v6512 144 13 with with IN cord-304472-mi5v6512 144 14 the the DT cord-304472-mi5v6512 144 15 main main JJ cord-304472-mi5v6512 144 16 difference difference NN cord-304472-mi5v6512 144 17 between between IN cord-304472-mi5v6512 144 18 them -PRON- PRP cord-304472-mi5v6512 144 19 being be VBG cord-304472-mi5v6512 144 20 the the DT cord-304472-mi5v6512 144 21 type type NN cord-304472-mi5v6512 144 22 of of IN cord-304472-mi5v6512 144 23 backbone backbone NN cord-304472-mi5v6512 144 24 and and CC cord-304472-mi5v6512 144 25 the the DT cord-304472-mi5v6512 144 26 extent extent NN cord-304472-mi5v6512 144 27 of of IN cord-304472-mi5v6512 144 28 chimerization chimerization NN cord-304472-mi5v6512 144 29 . . . cord-304472-mi5v6512 145 1 While while IN cord-304472-mi5v6512 145 2 CYD CYD NNP cord-304472-mi5v6512 145 3 - - HYPH cord-304472-mi5v6512 145 4 TDV TDV NNP cord-304472-mi5v6512 145 5 ( ( -LRB- cord-304472-mi5v6512 145 6 the the DT cord-304472-mi5v6512 145 7 first first JJ cord-304472-mi5v6512 145 8 licensed licensed JJ cord-304472-mi5v6512 145 9 dengue dengue NN cord-304472-mi5v6512 145 10 vaccine vaccine NN cord-304472-mi5v6512 145 11 ) ) -RRB- cord-304472-mi5v6512 145 12 does do VBZ cord-304472-mi5v6512 145 13 not not RB cord-304472-mi5v6512 145 14 include include VB cord-304472-mi5v6512 145 15 non non JJ cord-304472-mi5v6512 145 16 - - JJ cord-304472-mi5v6512 145 17 structural structural JJ cord-304472-mi5v6512 145 18 proteins protein NNS cord-304472-mi5v6512 145 19 of of IN cord-304472-mi5v6512 145 20 dengue dengue NN cord-304472-mi5v6512 145 21 , , , cord-304472-mi5v6512 145 22 TAK-003 tak-003 NN cord-304472-mi5v6512 145 23 contains contain VBZ cord-304472-mi5v6512 145 24 the the DT cord-304472-mi5v6512 145 25 dengue dengue NN cord-304472-mi5v6512 145 26 virus virus NN cord-304472-mi5v6512 145 27 serotype serotype NN cord-304472-mi5v6512 145 28 2 2 CD cord-304472-mi5v6512 145 29 backbone backbone NN cord-304472-mi5v6512 145 30 , , , cord-304472-mi5v6512 145 31 and and CC cord-304472-mi5v6512 145 32 the the DT cord-304472-mi5v6512 145 33 Butantan Butantan NNP cord-304472-mi5v6512 145 34 / / SYM cord-304472-mi5v6512 145 35 Merck Merck NNP cord-304472-mi5v6512 145 36 vaccine vaccine NN cord-304472-mi5v6512 145 37 contains contain VBZ cord-304472-mi5v6512 145 38 three three CD cord-304472-mi5v6512 145 39 full full JJ cord-304472-mi5v6512 145 40 - - HYPH cord-304472-mi5v6512 145 41 genomes genome NNS cord-304472-mi5v6512 145 42 of of IN cord-304472-mi5v6512 145 43 the the DT cord-304472-mi5v6512 145 44 four four CD cord-304472-mi5v6512 145 45 dengue dengue NN cord-304472-mi5v6512 145 46 virus virus NN cord-304472-mi5v6512 145 47 serotypes serotype NNS cord-304472-mi5v6512 145 48 . . . cord-304472-mi5v6512 146 1 The the DT cord-304472-mi5v6512 146 2 four four CD cord-304472-mi5v6512 146 3 genetically genetically RB cord-304472-mi5v6512 146 4 succinct succinct JJ cord-304472-mi5v6512 146 5 but but CC cord-304472-mi5v6512 146 6 still still RB cord-304472-mi5v6512 146 7 closely closely RB cord-304472-mi5v6512 146 8 related related JJ cord-304472-mi5v6512 146 9 dengue dengue NN cord-304472-mi5v6512 146 10 serotypes serotype NNS cord-304472-mi5v6512 146 11 are be VBP cord-304472-mi5v6512 146 12 known know VBN cord-304472-mi5v6512 146 13 to to TO cord-304472-mi5v6512 146 14 interact interact VB cord-304472-mi5v6512 146 15 immunologically immunologically RB cord-304472-mi5v6512 146 16 with with IN cord-304472-mi5v6512 146 17 potential potential NN cord-304472-mi5v6512 146 18 for for IN cord-304472-mi5v6512 146 19 disease disease NN cord-304472-mi5v6512 146 20 enhancement enhancement NN cord-304472-mi5v6512 146 21 . . . cord-304472-mi5v6512 147 1 While while IN cord-304472-mi5v6512 147 2 dengueprimed dengueprime VBN cord-304472-mi5v6512 147 3 individuals individual NNS cord-304472-mi5v6512 147 4 can can MD cord-304472-mi5v6512 147 5 already already RB cord-304472-mi5v6512 147 6 benefit benefit VB cord-304472-mi5v6512 147 7 from from IN cord-304472-mi5v6512 147 8 vaccination vaccination NN cord-304472-mi5v6512 147 9 against against IN cord-304472-mi5v6512 147 10 all all DT cord-304472-mi5v6512 147 11 four four CD cord-304472-mi5v6512 147 12 serotypes serotype NNS cord-304472-mi5v6512 147 13 with with IN cord-304472-mi5v6512 147 14 the the DT cord-304472-mi5v6512 147 15 first first JJ cord-304472-mi5v6512 147 16 licensed licensed JJ cord-304472-mi5v6512 147 17 dengue dengue NN cord-304472-mi5v6512 147 18 vaccine vaccine NN cord-304472-mi5v6512 147 19 CYD CYD NNP cord-304472-mi5v6512 147 20 - - HYPH cord-304472-mi5v6512 147 21 TDV TDV NNP cord-304472-mi5v6512 147 22 , , , cord-304472-mi5v6512 147 23 the the DT cord-304472-mi5v6512 147 24 need need NN cord-304472-mi5v6512 147 25 for for IN cord-304472-mi5v6512 147 26 dengue dengue NN cord-304472-mi5v6512 147 27 - - HYPH cord-304472-mi5v6512 147 28 naive naive JJ cord-304472-mi5v6512 147 29 population population NN cord-304472-mi5v6512 147 30 has have VBZ cord-304472-mi5v6512 147 31 not not RB cord-304472-mi5v6512 147 32 yet yet RB cord-304472-mi5v6512 147 33 been be VBN cord-304472-mi5v6512 147 34 met meet VBN cord-304472-mi5v6512 147 35 . . . cord-304472-mi5v6512 148 1 To to TO cord-304472-mi5v6512 148 2 improve improve VB cord-304472-mi5v6512 148 3 tetravalent tetravalent NN cord-304472-mi5v6512 148 4 protection protection NN cord-304472-mi5v6512 148 5 , , , cord-304472-mi5v6512 148 6 sequential sequential JJ cord-304472-mi5v6512 148 7 vaccination vaccination NN cord-304472-mi5v6512 148 8 should should MD cord-304472-mi5v6512 148 9 be be VB cord-304472-mi5v6512 148 10 considered consider VBN cord-304472-mi5v6512 148 11 in in IN cord-304472-mi5v6512 148 12 addition addition NN cord-304472-mi5v6512 148 13 to to IN cord-304472-mi5v6512 148 14 a a DT cord-304472-mi5v6512 148 15 heterologous heterologous JJ cord-304472-mi5v6512 148 16 prime prime JJ cord-304472-mi5v6512 148 17 - - HYPH cord-304472-mi5v6512 148 18 boost boost NN cord-304472-mi5v6512 148 19 approach approach NN cord-304472-mi5v6512 148 20 . . . cord-304472-mi5v6512 149 1 The the DT cord-304472-mi5v6512 149 2 ideal ideal JJ cord-304472-mi5v6512 149 3 properties property NNS cord-304472-mi5v6512 149 4 of of IN cord-304472-mi5v6512 149 5 a a DT cord-304472-mi5v6512 149 6 dengue dengue NN cord-304472-mi5v6512 149 7 vaccine vaccine NN cord-304472-mi5v6512 149 8 should should MD cord-304472-mi5v6512 149 9 include include VB cord-304472-mi5v6512 149 10 the the DT cord-304472-mi5v6512 149 11 ability ability NN cord-304472-mi5v6512 149 12 to to TO cord-304472-mi5v6512 149 13 induce induce VB cord-304472-mi5v6512 149 14 long long RB cord-304472-mi5v6512 149 15 - - HYPH cord-304472-mi5v6512 149 16 lasting last VBG cord-304472-mi5v6512 149 17 homotypic homotypic JJ cord-304472-mi5v6512 149 18 immune immune JJ cord-304472-mi5v6512 149 19 responses response NNS cord-304472-mi5v6512 149 20 to to IN cord-304472-mi5v6512 149 21 all all DT cord-304472-mi5v6512 149 22 four four CD cord-304472-mi5v6512 149 23 serotypes serotype NNS cord-304472-mi5v6512 149 24 in in IN cord-304472-mi5v6512 149 25 all all DT cord-304472-mi5v6512 149 26 age age NN cord-304472-mi5v6512 149 27 groups group NNS cord-304472-mi5v6512 149 28 , , , cord-304472-mi5v6512 149 29 regardless regardless RB cord-304472-mi5v6512 149 30 of of IN cord-304472-mi5v6512 149 31 dengue dengue NN cord-304472-mi5v6512 149 32 serostatus serostatus NN cord-304472-mi5v6512 149 33 . . . cord-304472-mi5v6512 150 1 The the DT cord-304472-mi5v6512 150 2 vaccine vaccine NN cord-304472-mi5v6512 150 3 should should MD cord-304472-mi5v6512 150 4 have have VB cord-304472-mi5v6512 150 5 a a DT cord-304472-mi5v6512 150 6 schedule schedule NN cord-304472-mi5v6512 150 7 ideally ideally RB cord-304472-mi5v6512 150 8 with with IN cord-304472-mi5v6512 150 9 2 2 CD cord-304472-mi5v6512 150 10 or or CC cord-304472-mi5v6512 150 11 fewer few JJR cord-304472-mi5v6512 150 12 doses dose NNS cord-304472-mi5v6512 150 13 , , , cord-304472-mi5v6512 150 14 should should MD cord-304472-mi5v6512 150 15 be be VB cord-304472-mi5v6512 150 16 able able JJ cord-304472-mi5v6512 150 17 to to TO cord-304472-mi5v6512 150 18 prevent prevent VB cord-304472-mi5v6512 150 19 dengue dengue NN cord-304472-mi5v6512 150 20 outbreaks outbreak NNS cord-304472-mi5v6512 150 21 if if IN cord-304472-mi5v6512 150 22 used use VBN cord-304472-mi5v6512 150 23 early early RB cord-304472-mi5v6512 150 24 at at IN cord-304472-mi5v6512 150 25 the the DT cord-304472-mi5v6512 150 26 onset onset NN cord-304472-mi5v6512 150 27 of of IN cord-304472-mi5v6512 150 28 the the DT cord-304472-mi5v6512 150 29 outbreak outbreak NN cord-304472-mi5v6512 150 30 , , , cord-304472-mi5v6512 150 31 and and CC cord-304472-mi5v6512 150 32 should should MD cord-304472-mi5v6512 150 33 serve serve VB cord-304472-mi5v6512 150 34 as as IN cord-304472-mi5v6512 150 35 prophylaxis prophylaxis NN cord-304472-mi5v6512 150 36 in in IN cord-304472-mi5v6512 150 37 large large JJ cord-304472-mi5v6512 150 38 populations population NNS cord-304472-mi5v6512 150 39 to to TO cord-304472-mi5v6512 150 40 effectively effectively RB cord-304472-mi5v6512 150 41 prevent prevent VB cord-304472-mi5v6512 150 42 epidemics epidemic NNS cord-304472-mi5v6512 150 43 in in IN cord-304472-mi5v6512 150 44 the the DT cord-304472-mi5v6512 150 45 long long JJ cord-304472-mi5v6512 150 46 term term NN cord-304472-mi5v6512 150 47 . . . cord-304472-mi5v6512 151 1 AWS AWS NNP cord-304472-mi5v6512 151 2 wrote write VBD cord-304472-mi5v6512 151 3 the the DT cord-304472-mi5v6512 151 4 review review NN cord-304472-mi5v6512 151 5 . . . cord-304472-mi5v6512 152 1 None none NN cord-304472-mi5v6512 152 2 . . . cord-304472-mi5v6512 153 1 Severe severe JJ cord-304472-mi5v6512 153 2 dengue dengue NN cord-304472-mi5v6512 153 3 in in IN cord-304472-mi5v6512 153 4 travellers traveller NNS cord-304472-mi5v6512 153 5 : : : cord-304472-mi5v6512 153 6 pathogenesis pathogenesis NN cord-304472-mi5v6512 153 7 , , , cord-304472-mi5v6512 153 8 risk risk NN cord-304472-mi5v6512 153 9 and and CC cord-304472-mi5v6512 153 10 clinical clinical JJ cord-304472-mi5v6512 153 11 management management NN cord-304472-mi5v6512 153 12 Dengue dengue NN cord-304472-mi5v6512 153 13 infection infection NN cord-304472-mi5v6512 153 14 in in IN cord-304472-mi5v6512 153 15 international international JJ cord-304472-mi5v6512 153 16 travellers traveller NNS cord-304472-mi5v6512 153 17 visiting visit VBG cord-304472-mi5v6512 153 18 Bali Bali NNP cord-304472-mi5v6512 153 19 , , , cord-304472-mi5v6512 153 20 Indonesia Indonesia NNP cord-304472-mi5v6512 153 21 Imported import VBN cord-304472-mi5v6512 153 22 dengue dengue NN cord-304472-mi5v6512 153 23 fever fever NN cord-304472-mi5v6512 153 24 in in IN cord-304472-mi5v6512 153 25 East East NNP cord-304472-mi5v6512 153 26 London London NNP cord-304472-mi5v6512 153 27 : : : cord-304472-mi5v6512 153 28 a a DT cord-304472-mi5v6512 153 29 6-year 6-year JJ cord-304472-mi5v6512 153 30 retrospective retrospective JJ cord-304472-mi5v6512 153 31 observational observational JJ cord-304472-mi5v6512 153 32 study study NN cord-304472-mi5v6512 153 33 Dengue dengue NN cord-304472-mi5v6512 153 34 fever fever NN cord-304472-mi5v6512 153 35 among among IN cord-304472-mi5v6512 153 36 Israeli israeli JJ cord-304472-mi5v6512 153 37 expatriates expatriate NNS cord-304472-mi5v6512 153 38 in in IN cord-304472-mi5v6512 153 39 Delhi Delhi NNP cord-304472-mi5v6512 153 40 , , , cord-304472-mi5v6512 153 41 2015 2015 CD cord-304472-mi5v6512 154 1 : : : cord-304472-mi5v6512 154 2 implications implication NNS cord-304472-mi5v6512 154 3 for for IN cord-304472-mi5v6512 154 4 dengue dengue NN cord-304472-mi5v6512 154 5 incidence incidence NN cord-304472-mi5v6512 154 6 in in IN cord-304472-mi5v6512 154 7 Delhi Delhi NNP cord-304472-mi5v6512 154 8 , , , cord-304472-mi5v6512 154 9 India India NNP cord-304472-mi5v6512 154 10 Risk Risk NNP cord-304472-mi5v6512 154 11 of of IN cord-304472-mi5v6512 154 12 severe severe JJ cord-304472-mi5v6512 154 13 dengue dengue NN cord-304472-mi5v6512 154 14 is be VBZ cord-304472-mi5v6512 154 15 higher high JJR cord-304472-mi5v6512 154 16 in in IN cord-304472-mi5v6512 154 17 patients patient NNS cord-304472-mi5v6512 154 18 with with IN cord-304472-mi5v6512 154 19 sickle sickle NN cord-304472-mi5v6512 154 20 cell cell NN cord-304472-mi5v6512 154 21 disease disease NN cord-304472-mi5v6512 154 22 : : : cord-304472-mi5v6512 154 23 a a DT cord-304472-mi5v6512 154 24 scoping scoping NN cord-304472-mi5v6512 154 25 review review NN cord-304472-mi5v6512 154 26 Efficacy Efficacy NNP cord-304472-mi5v6512 154 27 and and CC cord-304472-mi5v6512 154 28 long long JJ cord-304472-mi5v6512 154 29 - - HYPH cord-304472-mi5v6512 154 30 term term NN cord-304472-mi5v6512 154 31 safety safety NN cord-304472-mi5v6512 154 32 of of IN cord-304472-mi5v6512 154 33 a a DT cord-304472-mi5v6512 154 34 dengue dengue NN cord-304472-mi5v6512 154 35 vaccine vaccine NN cord-304472-mi5v6512 154 36 in in IN cord-304472-mi5v6512 154 37 regions region NNS cord-304472-mi5v6512 154 38 of of IN cord-304472-mi5v6512 154 39 endemic endemic JJ cord-304472-mi5v6512 154 40 disease disease NN cord-304472-mi5v6512 154 41 Effect effect NN cord-304472-mi5v6512 154 42 of of IN cord-304472-mi5v6512 154 43 dengue dengue NN cord-304472-mi5v6512 154 44 serostatus serostatus NN cord-304472-mi5v6512 154 45 on on IN cord-304472-mi5v6512 154 46 dengue dengue NN cord-304472-mi5v6512 154 47 vaccine vaccine NN cord-304472-mi5v6512 154 48 safety safety NN cord-304472-mi5v6512 154 49 and and CC cord-304472-mi5v6512 154 50 efficacy efficacy NN cord-304472-mi5v6512 154 51 Long long JJ cord-304472-mi5v6512 154 52 - - HYPH cord-304472-mi5v6512 154 53 term term NN cord-304472-mi5v6512 154 54 follow follow NN cord-304472-mi5v6512 154 55 - - HYPH cord-304472-mi5v6512 154 56 up up NN cord-304472-mi5v6512 154 57 of of IN cord-304472-mi5v6512 154 58 all all DT cord-304472-mi5v6512 154 59 Phase phase NN cord-304472-mi5v6512 154 60 3 3 CD cord-304472-mi5v6512 154 61 trial trial NN cord-304472-mi5v6512 154 62 data datum NNS cord-304472-mi5v6512 154 63 globally globally RB cord-304472-mi5v6512 154 64 including include VBG cord-304472-mi5v6512 154 65 benefit benefit NN cord-304472-mi5v6512 154 66 risk risk NN cord-304472-mi5v6512 154 67 assessment assessment NN cord-304472-mi5v6512 154 68 based base VBN cord-304472-mi5v6512 154 69 on on IN cord-304472-mi5v6512 154 70 stratification stratification NN cord-304472-mi5v6512 154 71 based base VBN cord-304472-mi5v6512 154 72 on on IN cord-304472-mi5v6512 154 73 baseline baseline JJ cord-304472-mi5v6512 154 74 serostatus serostatus NN cord-304472-mi5v6512 154 75 Deliberations deliberation NNS cord-304472-mi5v6512 154 76 of of IN cord-304472-mi5v6512 154 77 the the DT cord-304472-mi5v6512 154 78 strategic strategic JJ cord-304472-mi5v6512 154 79 advisory advisory JJ cord-304472-mi5v6512 154 80 group group NN cord-304472-mi5v6512 154 81 of of IN cord-304472-mi5v6512 154 82 experts expert NNS cord-304472-mi5v6512 154 83 on on IN cord-304472-mi5v6512 154 84 immunization immunization NN cord-304472-mi5v6512 154 85 on on IN cord-304472-mi5v6512 154 86 the the DT cord-304472-mi5v6512 154 87 use use NN cord-304472-mi5v6512 154 88 of of IN cord-304472-mi5v6512 155 1 CYD CYD NNP cord-304472-mi5v6512 155 2 - - HYPH cord-304472-mi5v6512 155 3 TDV TDV NNP cord-304472-mi5v6512 155 4 dengue dengue NN cord-304472-mi5v6512 155 5 vaccine vaccine NN cord-304472-mi5v6512 155 6 Dengue Dengue NNP cord-304472-mi5v6512 155 7 virus virus NN cord-304472-mi5v6512 155 8 NS1 ns1 NN cord-304472-mi5v6512 155 9 protein protein NN cord-304472-mi5v6512 155 10 activates activate VBZ cord-304472-mi5v6512 155 11 cells cell NNS cord-304472-mi5v6512 155 12 via via IN cord-304472-mi5v6512 155 13 Toll toll NN cord-304472-mi5v6512 155 14 - - HYPH cord-304472-mi5v6512 155 15 like like JJ cord-304472-mi5v6512 155 16 receptor receptor NN cord-304472-mi5v6512 155 17 4 4 CD cord-304472-mi5v6512 155 18 and and CC cord-304472-mi5v6512 155 19 disrupts disrupt VBZ cord-304472-mi5v6512 155 20 endothelial endothelial JJ cord-304472-mi5v6512 155 21 cell cell NN cord-304472-mi5v6512 155 22 monolayer monolayer NN cord-304472-mi5v6512 155 23 integrity integrity NN cord-304472-mi5v6512 155 24 Dengue dengue NN cord-304472-mi5v6512 155 25 virus virus NN cord-304472-mi5v6512 155 26 NS1 NS1 VBZ cord-304472-mi5v6512 155 27 triggers trigger VBZ cord-304472-mi5v6512 155 28 endothelial endothelial JJ cord-304472-mi5v6512 155 29 permeability permeability NN cord-304472-mi5v6512 155 30 and and CC cord-304472-mi5v6512 155 31 vascular vascular JJ cord-304472-mi5v6512 155 32 leak leak NN cord-304472-mi5v6512 155 33 that that WDT cord-304472-mi5v6512 155 34 is be VBZ cord-304472-mi5v6512 155 35 prevented prevent VBN cord-304472-mi5v6512 155 36 by by IN cord-304472-mi5v6512 155 37 NS1 NS1 NNS cord-304472-mi5v6512 155 38 vaccination vaccination NN cord-304472-mi5v6512 155 39 Dengue dengue NN cord-304472-mi5v6512 155 40 virus virus NN cord-304472-mi5v6512 155 41 NS1 ns1 CD cord-304472-mi5v6512 155 42 cytokine cytokine JJ cord-304472-mi5v6512 155 43 - - HYPH cord-304472-mi5v6512 155 44 independent independent JJ cord-304472-mi5v6512 155 45 vascular vascular JJ cord-304472-mi5v6512 155 46 leak leak NN cord-304472-mi5v6512 155 47 is be VBZ cord-304472-mi5v6512 155 48 dependent dependent JJ cord-304472-mi5v6512 155 49 on on IN cord-304472-mi5v6512 155 50 endothelial endothelial JJ cord-304472-mi5v6512 155 51 glycocalyx glycocalyx NN cord-304472-mi5v6512 155 52 components component NNS cord-304472-mi5v6512 155 53 Dengue Dengue NNP cord-304472-mi5v6512 155 54 virus virus NN cord-304472-mi5v6512 155 55 NS1 ns1 NN cord-304472-mi5v6512 155 56 disrupts disrupt VBZ cord-304472-mi5v6512 155 57 the the DT cord-304472-mi5v6512 155 58 endothelial endothelial JJ cord-304472-mi5v6512 155 59 glycocalyx glycocalyx NN cord-304472-mi5v6512 155 60 , , , cord-304472-mi5v6512 155 61 leading lead VBG cord-304472-mi5v6512 155 62 to to IN cord-304472-mi5v6512 155 63 hyperpermeability hyperpermeability NN cord-304472-mi5v6512 155 64 Dengue Dengue NNP cord-304472-mi5v6512 155 65 vaccine vaccine NN cord-304472-mi5v6512 155 66 : : : cord-304472-mi5v6512 155 67 WHO who WP cord-304472-mi5v6512 155 68 position position VBP cord-304472-mi5v6512 155 69 paper paper NN cord-304472-mi5v6512 155 70 Dengue dengue NN cord-304472-mi5v6512 155 71 prevaccination prevaccination NN cord-304472-mi5v6512 155 72 serology serology NN cord-304472-mi5v6512 155 73 screening screening NN cord-304472-mi5v6512 155 74 for for IN cord-304472-mi5v6512 155 75 the the DT cord-304472-mi5v6512 155 76 use use NN cord-304472-mi5v6512 155 77 of of IN cord-304472-mi5v6512 155 78 Dengvaxia(R dengvaxia(r NN cord-304472-mi5v6512 155 79 ) ) -RRB- cord-304472-mi5v6512 155 80 CYD CYD NNP cord-304472-mi5v6512 155 81 - - HYPH cord-304472-mi5v6512 155 82 TDV TDV NNP cord-304472-mi5v6512 155 83 dengue dengue NN cord-304472-mi5v6512 155 84 vaccine vaccine NN cord-304472-mi5v6512 155 85 performance performance NN cord-304472-mi5v6512 155 86 by by IN cord-304472-mi5v6512 155 87 baseline baseline JJ cord-304472-mi5v6512 155 88 immune immune NN cord-304472-mi5v6512 155 89 profile profile NN cord-304472-mi5v6512 155 90 ( ( -LRB- cord-304472-mi5v6512 155 91 monotypic/ monotypic/ CD cord-304472-mi5v6512 155 92 multitypic multitypic JJ cord-304472-mi5v6512 155 93 ) ) -RRB- cord-304472-mi5v6512 155 94 in in IN cord-304472-mi5v6512 155 95 dengue dengue NN cord-304472-mi5v6512 155 96 seropositive seropositive JJ cord-304472-mi5v6512 155 97 individuals individual NNS cord-304472-mi5v6512 155 98 . . . cord-304472-mi5v6512 156 1 Clin Clin NNP cord-304472-mi5v6512 156 2 Infect infect NN cord-304472-mi5v6512 156 3 Dis Dis NNP cord-304472-mi5v6512 156 4 2020 2020 CD cord-304472-mi5v6512 156 5 . . . cord-304472-mi5v6512 157 1 Evaluation evaluation NN cord-304472-mi5v6512 157 2 of of IN cord-304472-mi5v6512 157 3 several several JJ cord-304472-mi5v6512 157 4 ELISA ELISA NNP cord-304472-mi5v6512 157 5 and and CC cord-304472-mi5v6512 157 6 rapid rapid JJ cord-304472-mi5v6512 157 7 diagnostic diagnostic JJ cord-304472-mi5v6512 157 8 assays assay NNS cord-304472-mi5v6512 157 9 for for IN cord-304472-mi5v6512 157 10 determining determine VBG cord-304472-mi5v6512 157 11 prior prior JJ cord-304472-mi5v6512 157 12 dengue dengue NN cord-304472-mi5v6512 157 13 infection infection NN cord-304472-mi5v6512 157 14 Evaluation Evaluation NNP cord-304472-mi5v6512 157 15 of of IN cord-304472-mi5v6512 157 16 rapid rapid JJ cord-304472-mi5v6512 157 17 diagnostic diagnostic JJ cord-304472-mi5v6512 157 18 tests test NNS cord-304472-mi5v6512 157 19 and and CC cord-304472-mi5v6512 157 20 conventional conventional JJ cord-304472-mi5v6512 157 21 enzymelinked enzymelinked JJ cord-304472-mi5v6512 157 22 immunosorbent immunosorbent JJ cord-304472-mi5v6512 157 23 assays assay NNS cord-304472-mi5v6512 157 24 to to TO cord-304472-mi5v6512 157 25 determine determine VB cord-304472-mi5v6512 157 26 prior prior JJ cord-304472-mi5v6512 157 27 dengue dengue NN cord-304472-mi5v6512 157 28 infection infection NN cord-304472-mi5v6512 157 29 Pre pre JJ cord-304472-mi5v6512 157 30 - - JJ cord-304472-mi5v6512 157 31 vaccination vaccination JJ cord-304472-mi5v6512 157 32 screening screening NN cord-304472-mi5v6512 157 33 strategies strategy NNS cord-304472-mi5v6512 157 34 for for IN cord-304472-mi5v6512 157 35 the the DT cord-304472-mi5v6512 157 36 use use NN cord-304472-mi5v6512 157 37 of of IN cord-304472-mi5v6512 157 38 the the DT cord-304472-mi5v6512 157 39 CYD CYD NNP cord-304472-mi5v6512 157 40 - - HYPH cord-304472-mi5v6512 157 41 TDV TDV NNP cord-304472-mi5v6512 157 42 dengue dengue NN cord-304472-mi5v6512 157 43 vaccine vaccine NN cord-304472-mi5v6512 157 44 : : : cord-304472-mi5v6512 158 1 a a DT cord-304472-mi5v6512 158 2 meeting meeting NN cord-304472-mi5v6512 158 3 report report NN cord-304472-mi5v6512 158 4 Use Use NNP cord-304472-mi5v6512 158 5 of of IN cord-304472-mi5v6512 158 6 pre pre JJ cord-304472-mi5v6512 158 7 - - JJ cord-304472-mi5v6512 158 8 travel travel JJ cord-304472-mi5v6512 158 9 vaccine vaccine NN cord-304472-mi5v6512 158 10 - - HYPH cord-304472-mi5v6512 158 11 preventable preventable JJ cord-304472-mi5v6512 158 12 disease disease NN cord-304472-mi5v6512 158 13 serology serology NN cord-304472-mi5v6512 158 14 as as IN cord-304472-mi5v6512 158 15 a a DT cord-304472-mi5v6512 158 16 screening screening NN cord-304472-mi5v6512 158 17 tool tool NN cord-304472-mi5v6512 158 18 to to TO cord-304472-mi5v6512 158 19 identify identify VB cord-304472-mi5v6512 158 20 patients patient NNS cord-304472-mi5v6512 158 21 in in IN cord-304472-mi5v6512 158 22 need need NN cord-304472-mi5v6512 158 23 of of IN cord-304472-mi5v6512 158 24 pre pre JJ cord-304472-mi5v6512 158 25 - - JJ cord-304472-mi5v6512 158 26 travel travel JJ cord-304472-mi5v6512 158 27 vaccination vaccination NN cord-304472-mi5v6512 158 28 : : : cord-304472-mi5v6512 158 29 a a DT cord-304472-mi5v6512 158 30 retrospective retrospective JJ cord-304472-mi5v6512 158 31 audit audit NN cord-304472-mi5v6512 158 32 A a NN cord-304472-mi5v6512 158 33 : : : cord-304472-mi5v6512 158 34 Serostatus serostatus NN cord-304472-mi5v6512 158 35 - - HYPH cord-304472-mi5v6512 158 36 dependent dependent JJ cord-304472-mi5v6512 158 37 performance performance NN cord-304472-mi5v6512 158 38 of of IN cord-304472-mi5v6512 158 39 the the DT cord-304472-mi5v6512 158 40 first first JJ cord-304472-mi5v6512 158 41 licensed licensed JJ cord-304472-mi5v6512 158 42 dengue dengue NN cord-304472-mi5v6512 158 43 vaccine vaccine NN cord-304472-mi5v6512 158 44 : : : cord-304472-mi5v6512 158 45 implications implication NNS cord-304472-mi5v6512 158 46 for for IN cord-304472-mi5v6512 158 47 travellers traveller NNS cord-304472-mi5v6512 158 48 Timing Timing NNP cord-304472-mi5v6512 158 49 of of IN cord-304472-mi5v6512 158 50 administration administration NN cord-304472-mi5v6512 158 51 of of IN cord-304472-mi5v6512 158 52 dengue dengue NNP cord-304472-mi5v6512 158 53 vaccine vaccine NN cord-304472-mi5v6512 158 54 in in IN cord-304472-mi5v6512 158 55 travellers traveller NNS cord-304472-mi5v6512 158 56 with with IN cord-304472-mi5v6512 158 57 a a DT cord-304472-mi5v6512 158 58 recent recent JJ cord-304472-mi5v6512 158 59 confirmed confirm VBN cord-304472-mi5v6512 158 60 dengue dengue NN cord-304472-mi5v6512 158 61 infection infection NN cord-304472-mi5v6512 158 62 Clinical clinical JJ cord-304472-mi5v6512 158 63 development development NN cord-304472-mi5v6512 158 64 and and CC cord-304472-mi5v6512 158 65 regulatory regulatory JJ cord-304472-mi5v6512 158 66 points point NNS cord-304472-mi5v6512 158 67 for for IN cord-304472-mi5v6512 158 68 consideration consideration NN cord-304472-mi5v6512 158 69 for for IN cord-304472-mi5v6512 158 70 second second JJ cord-304472-mi5v6512 158 71 - - HYPH cord-304472-mi5v6512 158 72 generation generation NN cord-304472-mi5v6512 158 73 live live VBP cord-304472-mi5v6512 158 74 attenuated attenuated JJ cord-304472-mi5v6512 158 75 dengue dengue NN cord-304472-mi5v6512 158 76 vaccines vaccine VBZ cord-304472-mi5v6512 158 77 A a DT cord-304472-mi5v6512 159 1 : : : cord-304472-mi5v6512 159 2 Evaluation evaluation NN cord-304472-mi5v6512 159 3 of of IN cord-304472-mi5v6512 159 4 a a DT cord-304472-mi5v6512 159 5 tetravalent tetravalent NN cord-304472-mi5v6512 159 6 dengue dengue NN cord-304472-mi5v6512 159 7 vaccine vaccine NN cord-304472-mi5v6512 159 8 by by IN cord-304472-mi5v6512 159 9 serostatus serostatus NN cord-304472-mi5v6512 159 10 and and CC cord-304472-mi5v6512 159 11 serotype serotype NN cord-304472-mi5v6512 159 12 A a DT cord-304472-mi5v6512 159 13 recombinant recombinant JJ cord-304472-mi5v6512 159 14 , , , cord-304472-mi5v6512 159 15 chimeric chimeric JJ cord-304472-mi5v6512 159 16 tetravalent tetravalent NN cord-304472-mi5v6512 159 17 dengue dengue NN cord-304472-mi5v6512 159 18 vaccine vaccine NN cord-304472-mi5v6512 159 19 candidate candidate NN cord-304472-mi5v6512 159 20 based base VBN cord-304472-mi5v6512 159 21 on on IN cord-304472-mi5v6512 159 22 a a DT cord-304472-mi5v6512 159 23 dengue dengue NN cord-304472-mi5v6512 159 24 virus virus NN cord-304472-mi5v6512 159 25 serotype serotype NN cord-304472-mi5v6512 159 26 2 2 CD cord-304472-mi5v6512 159 27 backbone backbone NN cord-304472-mi5v6512 159 28 Immunogenicity Immunogenicity NNP cord-304472-mi5v6512 159 29 and and CC cord-304472-mi5v6512 159 30 safety safety NN cord-304472-mi5v6512 159 31 of of IN cord-304472-mi5v6512 159 32 one one CD cord-304472-mi5v6512 159 33 versus versus IN cord-304472-mi5v6512 159 34 two two CD cord-304472-mi5v6512 159 35 doses dose NNS cord-304472-mi5v6512 159 36 of of IN cord-304472-mi5v6512 159 37 tetravalent tetravalent NNP cord-304472-mi5v6512 159 38 dengue dengue NN cord-304472-mi5v6512 159 39 vaccine vaccine NN cord-304472-mi5v6512 159 40 in in IN cord-304472-mi5v6512 159 41 healthy healthy JJ cord-304472-mi5v6512 159 42 children child NNS cord-304472-mi5v6512 159 43 aged age VBN cord-304472-mi5v6512 159 44 2 2 CD cord-304472-mi5v6512 159 45 - - SYM cord-304472-mi5v6512 159 46 17 17 CD cord-304472-mi5v6512 159 47 years year NNS cord-304472-mi5v6512 159 48 in in IN cord-304472-mi5v6512 159 49 Asia Asia NNP cord-304472-mi5v6512 159 50 and and CC cord-304472-mi5v6512 159 51 Latin Latin NNP cord-304472-mi5v6512 159 52 America America NNP cord-304472-mi5v6512 159 53 : : : cord-304472-mi5v6512 159 54 18-month 18-month JJ cord-304472-mi5v6512 159 55 interim interim JJ cord-304472-mi5v6512 159 56 data datum NNS cord-304472-mi5v6512 159 57 from from IN cord-304472-mi5v6512 159 58 a a DT cord-304472-mi5v6512 159 59 phase phase NN cord-304472-mi5v6512 159 60 2 2 CD cord-304472-mi5v6512 159 61 , , , cord-304472-mi5v6512 159 62 randomised randomised JJ cord-304472-mi5v6512 159 63 , , , cord-304472-mi5v6512 159 64 placebo placebo NN cord-304472-mi5v6512 159 65 - - HYPH cord-304472-mi5v6512 159 66 controlled control VBN cord-304472-mi5v6512 159 67 study study NN cord-304472-mi5v6512 159 68 Immunogenicity Immunogenicity NNP cord-304472-mi5v6512 159 69 and and CC cord-304472-mi5v6512 159 70 safety safety NN cord-304472-mi5v6512 159 71 of of IN cord-304472-mi5v6512 159 72 lyophilized lyophilized JJ cord-304472-mi5v6512 159 73 and and CC cord-304472-mi5v6512 159 74 liquid liquid JJ cord-304472-mi5v6512 159 75 dengue dengue NN cord-304472-mi5v6512 159 76 tetravalent tetravalent NN cord-304472-mi5v6512 159 77 vaccine vaccine NN cord-304472-mi5v6512 159 78 candidate candidate NN cord-304472-mi5v6512 159 79 formulations formulation NNS cord-304472-mi5v6512 159 80 in in IN cord-304472-mi5v6512 159 81 healthy healthy JJ cord-304472-mi5v6512 159 82 adults adult NNS cord-304472-mi5v6512 159 83 : : : cord-304472-mi5v6512 159 84 a a DT cord-304472-mi5v6512 159 85 randomized randomized JJ cord-304472-mi5v6512 159 86 , , , cord-304472-mi5v6512 159 87 phase phase NN cord-304472-mi5v6512 159 88 2 2 CD cord-304472-mi5v6512 159 89 clinical clinical JJ cord-304472-mi5v6512 159 90 trial trial NN cord-304472-mi5v6512 159 91 Characterization characterization NN cord-304472-mi5v6512 159 92 of of IN cord-304472-mi5v6512 159 93 the the DT cord-304472-mi5v6512 159 94 type type NN cord-304472-mi5v6512 159 95 - - HYPH cord-304472-mi5v6512 159 96 specific specific JJ cord-304472-mi5v6512 159 97 and and CC cord-304472-mi5v6512 159 98 crossreactive crossreactive JJ cord-304472-mi5v6512 159 99 B b NN cord-304472-mi5v6512 159 100 cell cell NN cord-304472-mi5v6512 159 101 responses response NNS cord-304472-mi5v6512 159 102 elicited elicit VBN cord-304472-mi5v6512 159 103 by by IN cord-304472-mi5v6512 159 104 a a DT cord-304472-mi5v6512 159 105 live live RB cord-304472-mi5v6512 159 106 - - HYPH cord-304472-mi5v6512 159 107 attenuated attenuated JJ cord-304472-mi5v6512 159 108 tetravalent tetravalent NN cord-304472-mi5v6512 159 109 dengue dengue NN cord-304472-mi5v6512 159 110 vaccine vaccine NN cord-304472-mi5v6512 159 111 Long long JJ cord-304472-mi5v6512 159 112 - - HYPH cord-304472-mi5v6512 159 113 term term NN cord-304472-mi5v6512 159 114 safety safety NN cord-304472-mi5v6512 159 115 and and CC cord-304472-mi5v6512 159 116 immunogenicity immunogenicity NN cord-304472-mi5v6512 159 117 of of IN cord-304472-mi5v6512 159 118 a a DT cord-304472-mi5v6512 159 119 tetravalent tetravalent NN cord-304472-mi5v6512 159 120 dengue dengue NN cord-304472-mi5v6512 159 121 vaccine vaccine NN cord-304472-mi5v6512 159 122 candidate candidate NN cord-304472-mi5v6512 159 123 in in IN cord-304472-mi5v6512 159 124 children child NNS cord-304472-mi5v6512 159 125 and and CC cord-304472-mi5v6512 159 126 adults adult NNS cord-304472-mi5v6512 159 127 : : : cord-304472-mi5v6512 159 128 a a DT cord-304472-mi5v6512 159 129 randomized randomized JJ cord-304472-mi5v6512 159 130 , , , cord-304472-mi5v6512 159 131 placebo placebo NN cord-304472-mi5v6512 159 132 - - HYPH cord-304472-mi5v6512 159 133 controlled control VBN cord-304472-mi5v6512 159 134 , , , cord-304472-mi5v6512 159 135 phase phase NN cord-304472-mi5v6512 159 136 2 2 CD cord-304472-mi5v6512 159 137 study study NN cord-304472-mi5v6512 159 138 Efficacy Efficacy NNP cord-304472-mi5v6512 159 139 of of IN cord-304472-mi5v6512 159 140 a a DT cord-304472-mi5v6512 159 141 tetravalent tetravalent NN cord-304472-mi5v6512 159 142 dengue dengue NN cord-304472-mi5v6512 159 143 vaccine vaccine NN cord-304472-mi5v6512 159 144 in in IN cord-304472-mi5v6512 159 145 healthy healthy JJ cord-304472-mi5v6512 159 146 children child NNS cord-304472-mi5v6512 159 147 and and CC cord-304472-mi5v6512 159 148 adolescents adolescent NNS cord-304472-mi5v6512 160 1 Efficacy efficacy NN cord-304472-mi5v6512 160 2 of of IN cord-304472-mi5v6512 160 3 a a DT cord-304472-mi5v6512 160 4 tetravalent tetravalent NN cord-304472-mi5v6512 160 5 dengue dengue NN cord-304472-mi5v6512 160 6 vaccine vaccine NN cord-304472-mi5v6512 160 7 in in IN cord-304472-mi5v6512 160 8 healthy healthy JJ cord-304472-mi5v6512 160 9 children child NNS cord-304472-mi5v6512 160 10 aged age VBN cord-304472-mi5v6512 160 11 4 4 CD cord-304472-mi5v6512 160 12 - - SYM cord-304472-mi5v6512 160 13 16 16 CD cord-304472-mi5v6512 160 14 years year NNS cord-304472-mi5v6512 160 15 : : : cord-304472-mi5v6512 160 16 a a DT cord-304472-mi5v6512 160 17 randomised randomised JJ cord-304472-mi5v6512 160 18 , , , cord-304472-mi5v6512 160 19 placebo placebo NN cord-304472-mi5v6512 160 20 - - HYPH cord-304472-mi5v6512 160 21 controlled control VBN cord-304472-mi5v6512 160 22 , , , cord-304472-mi5v6512 160 23 phase phase NN cord-304472-mi5v6512 160 24 3 3 CD cord-304472-mi5v6512 160 25 trial trial NN cord-304472-mi5v6512 160 26 Robust robust JJ cord-304472-mi5v6512 160 27 and and CC cord-304472-mi5v6512 160 28 balanced balanced JJ cord-304472-mi5v6512 160 29 immune immune JJ cord-304472-mi5v6512 160 30 responses response NNS cord-304472-mi5v6512 160 31 to to IN cord-304472-mi5v6512 160 32 all all DT cord-304472-mi5v6512 160 33 4 4 CD cord-304472-mi5v6512 160 34 Dengue dengue NN cord-304472-mi5v6512 160 35 virus virus NN cord-304472-mi5v6512 160 36 serotypes serotype NNS cord-304472-mi5v6512 160 37 following follow VBG cord-304472-mi5v6512 160 38 administration administration NN cord-304472-mi5v6512 160 39 of of IN cord-304472-mi5v6512 160 40 a a DT cord-304472-mi5v6512 160 41 single single JJ cord-304472-mi5v6512 160 42 dose dose NN cord-304472-mi5v6512 160 43 of of IN cord-304472-mi5v6512 160 44 a a DT cord-304472-mi5v6512 160 45 live live JJ cord-304472-mi5v6512 160 46 attenuated attenuated JJ cord-304472-mi5v6512 160 47 tetravalent tetravalent NN cord-304472-mi5v6512 160 48 dengue dengue NN cord-304472-mi5v6512 160 49 vaccine vaccine NN cord-304472-mi5v6512 160 50 to to IN cord-304472-mi5v6512 160 51 healthy healthy JJ cord-304472-mi5v6512 160 52 , , , cord-304472-mi5v6512 160 53 Flavivirus Flavivirus NNP cord-304472-mi5v6512 160 54 - - HYPH cord-304472-mi5v6512 160 55 naive naive JJ cord-304472-mi5v6512 160 56 adults adult NNS cord-304472-mi5v6512 161 1 Human Human NNP cord-304472-mi5v6512 161 2 CD4 CD4 NNP cord-304472-mi5v6512 161 3 + + CC cord-304472-mi5v6512 161 4 T t NN cord-304472-mi5v6512 161 5 cell cell NN cord-304472-mi5v6512 161 6 responses response NNS cord-304472-mi5v6512 161 7 to to IN cord-304472-mi5v6512 161 8 an an DT cord-304472-mi5v6512 161 9 attenuated attenuated JJ cord-304472-mi5v6512 161 10 tetravalent tetravalent NN cord-304472-mi5v6512 161 11 dengue dengue NN cord-304472-mi5v6512 161 12 vaccine vaccine NN cord-304472-mi5v6512 161 13 parallel parallel VBP cord-304472-mi5v6512 161 14 those those DT cord-304472-mi5v6512 161 15 induced induce VBN cord-304472-mi5v6512 161 16 by by IN cord-304472-mi5v6512 161 17 natural natural JJ cord-304472-mi5v6512 161 18 infection infection NN cord-304472-mi5v6512 161 19 in in IN cord-304472-mi5v6512 161 20 magnitude magnitude NN cord-304472-mi5v6512 161 21 , , , cord-304472-mi5v6512 161 22 HLA HLA NNP cord-304472-mi5v6512 161 23 restriction restriction NN cord-304472-mi5v6512 161 24 , , , cord-304472-mi5v6512 161 25 and and CC cord-304472-mi5v6512 161 26 antigen antigen NN cord-304472-mi5v6512 161 27 specificity specificity NN cord-304472-mi5v6512 162 1 The the DT cord-304472-mi5v6512 162 2 human human JJ cord-304472-mi5v6512 162 3 CD8 CD8 NNP cord-304472-mi5v6512 162 4 + + CC cord-304472-mi5v6512 162 5 T T NNP cord-304472-mi5v6512 162 6 cell cell NN cord-304472-mi5v6512 162 7 responses response NNS cord-304472-mi5v6512 162 8 induced induce VBN cord-304472-mi5v6512 162 9 by by IN cord-304472-mi5v6512 162 10 a a DT cord-304472-mi5v6512 162 11 live live JJ cord-304472-mi5v6512 162 12 attenuated attenuated JJ cord-304472-mi5v6512 162 13 tetravalent tetravalent NN cord-304472-mi5v6512 162 14 dengue dengue NN cord-304472-mi5v6512 162 15 vaccine vaccine NN cord-304472-mi5v6512 162 16 are be VBP cord-304472-mi5v6512 162 17 directed direct VBN cord-304472-mi5v6512 162 18 against against IN cord-304472-mi5v6512 162 19 highly highly RB cord-304472-mi5v6512 162 20 conserved conserve VBN cord-304472-mi5v6512 162 21 epitopes epitope NNS cord-304472-mi5v6512 163 1 A a DT cord-304472-mi5v6512 163 2 12-month 12-month JJ cord-304472-mi5v6512 163 3 - - HYPH cord-304472-mi5v6512 163 4 interval interval NN cord-304472-mi5v6512 163 5 dosing dosing NN cord-304472-mi5v6512 163 6 study study NN cord-304472-mi5v6512 163 7 in in IN cord-304472-mi5v6512 163 8 adults adult NNS cord-304472-mi5v6512 163 9 indicates indicate VBZ cord-304472-mi5v6512 163 10 that that IN cord-304472-mi5v6512 163 11 a a DT cord-304472-mi5v6512 163 12 single single JJ cord-304472-mi5v6512 163 13 dose dose NN cord-304472-mi5v6512 163 14 of of IN cord-304472-mi5v6512 163 15 the the DT cord-304472-mi5v6512 163 16 national national NNP cord-304472-mi5v6512 163 17 institute institute NNP cord-304472-mi5v6512 163 18 of of IN cord-304472-mi5v6512 163 19 allergy allergy NNP cord-304472-mi5v6512 163 20 and and CC cord-304472-mi5v6512 163 21 infectious infectious JJ cord-304472-mi5v6512 163 22 diseases disease NNS cord-304472-mi5v6512 163 23 tetravalent tetravalent NN cord-304472-mi5v6512 163 24 dengue dengue NN cord-304472-mi5v6512 163 25 vaccine vaccine NN cord-304472-mi5v6512 163 26 induces induce VBZ cord-304472-mi5v6512 163 27 a a DT cord-304472-mi5v6512 163 28 robust robust JJ cord-304472-mi5v6512 163 29 neutralizing neutralize VBG cord-304472-mi5v6512 163 30 antibody antibody NN cord-304472-mi5v6512 163 31 response response NN cord-304472-mi5v6512 163 32 Paediatric Paediatric NNP cord-304472-mi5v6512 163 33 Dengue Dengue NNP cord-304472-mi5v6512 163 34 Fever Fever NNP cord-304472-mi5v6512 163 35 diagnosed diagnose VBN cord-304472-mi5v6512 163 36 through through IN cord-304472-mi5v6512 163 37 parents parent NNS cord-304472-mi5v6512 163 38 ' ' POS cord-304472-mi5v6512 163 39 epidemiologic epidemiologic JJ cord-304472-mi5v6512 163 40 report report NN cord-304472-mi5v6512 163 41 and and CC cord-304472-mi5v6512 163 42 preventive preventive JJ cord-304472-mi5v6512 163 43 strategy strategy NN cord-304472-mi5v6512 163 44 during during IN cord-304472-mi5v6512 163 45 the the DT cord-304472-mi5v6512 163 46 acute acute JJ cord-304472-mi5v6512 163 47 phase phase NN cord-304472-mi5v6512 163 48 of of IN cord-304472-mi5v6512 163 49 infection infection NN cord-304472-mi5v6512 163 50 Dengue dengue NN cord-304472-mi5v6512 163 51 in in IN cord-304472-mi5v6512 163 52 peace peace NN cord-304472-mi5v6512 163 53 corps corps NN cord-304472-mi5v6512 163 54 volunteers volunteer NNS cord-304472-mi5v6512 163 55 Travel Travel NNP cord-304472-mi5v6512 163 56 vaccine vaccine NN cord-304472-mi5v6512 163 57 preventable preventable JJ cord-304472-mi5v6512 163 58 diseases disease NNS cord-304472-mi5v6512 163 59 - - HYPH cord-304472-mi5v6512 163 60 updated update VBN cord-304472-mi5v6512 163 61 logarithmic logarithmic JJ cord-304472-mi5v6512 163 62 scale scale NN cord-304472-mi5v6512 163 63 with with IN cord-304472-mi5v6512 163 64 monthly monthly JJ cord-304472-mi5v6512 163 65 incidence incidence NN cord-304472-mi5v6512 163 66 rates rate NNS cord-304472-mi5v6512 163 67 What what WDT cord-304472-mi5v6512 163 68 proportion proportion NN cord-304472-mi5v6512 163 69 of of IN cord-304472-mi5v6512 163 70 international international JJ cord-304472-mi5v6512 163 71 travellers traveller NNS cord-304472-mi5v6512 163 72 acquire acquire VBP cord-304472-mi5v6512 163 73 a a DT cord-304472-mi5v6512 163 74 travel travel NN cord-304472-mi5v6512 163 75 - - HYPH cord-304472-mi5v6512 163 76 related relate VBN cord-304472-mi5v6512 163 77 illness illness NN cord-304472-mi5v6512 163 78 ? ? . cord-304472-mi5v6512 164 1 A a DT cord-304472-mi5v6512 164 2 review review NN cord-304472-mi5v6512 164 3 of of IN cord-304472-mi5v6512 164 4 the the DT cord-304472-mi5v6512 164 5 literature literature NN cord-304472-mi5v6512 164 6 Prevention Prevention NNP cord-304472-mi5v6512 164 7 of of IN cord-304472-mi5v6512 164 8 enteric enteric JJ cord-304472-mi5v6512 164 9 fever fever NN cord-304472-mi5v6512 164 10 in in IN cord-304472-mi5v6512 164 11 travellers traveller NNS cord-304472-mi5v6512 164 12 with with IN cord-304472-mi5v6512 164 13 typhoid typhoid NN cord-304472-mi5v6512 164 14 conjugate conjugate NN cord-304472-mi5v6512 164 15 vaccines vaccine NNS cord-304472-mi5v6512 164 16 Perceptions perception NNS cord-304472-mi5v6512 164 17 of of IN cord-304472-mi5v6512 164 18 rabies rabies NN cord-304472-mi5v6512 164 19 risk risk NN cord-304472-mi5v6512 164 20 : : : cord-304472-mi5v6512 164 21 a a DT cord-304472-mi5v6512 164 22 survey survey NN cord-304472-mi5v6512 164 23 of of IN cord-304472-mi5v6512 164 24 travellers traveller NNS cord-304472-mi5v6512 164 25 and and CC cord-304472-mi5v6512 164 26 travel travel NN cord-304472-mi5v6512 164 27 clinics clinic NNS cord-304472-mi5v6512 164 28 from from IN cord-304472-mi5v6512 164 29 Canada Canada NNP cord-304472-mi5v6512 164 30 , , , cord-304472-mi5v6512 164 31 Germany Germany NNP cord-304472-mi5v6512 164 32 , , , cord-304472-mi5v6512 164 33 Sweden Sweden NNP cord-304472-mi5v6512 164 34 and and CC cord-304472-mi5v6512 164 35 the the DT cord-304472-mi5v6512 164 36 UK UK NNP cord-304472-mi5v6512 164 37 Pandemic Pandemic NNP cord-304472-mi5v6512 164 38 yellow yellow JJ cord-304472-mi5v6512 164 39 fever fever NN cord-304472-mi5v6512 164 40 : : : cord-304472-mi5v6512 164 41 a a DT cord-304472-mi5v6512 164 42 potential potential JJ cord-304472-mi5v6512 164 43 threat threat NN cord-304472-mi5v6512 164 44 to to IN cord-304472-mi5v6512 164 45 global global JJ cord-304472-mi5v6512 164 46 health health NN cord-304472-mi5v6512 164 47 via via IN cord-304472-mi5v6512 164 48 travelers traveler NNS cord-304472-mi5v6512 164 49 Recommendations Recommendations NNPS cord-304472-mi5v6512 164 50 for for IN cord-304472-mi5v6512 164 51 travellers traveller NNS cord-304472-mi5v6512 164 52 during during IN cord-304472-mi5v6512 164 53 the the DT cord-304472-mi5v6512 164 54 yellow yellow JJ cord-304472-mi5v6512 164 55 fever fever NN cord-304472-mi5v6512 164 56 outbreaks outbreak NNS cord-304472-mi5v6512 164 57 in in IN cord-304472-mi5v6512 164 58 Brazil-2018 Brazil-2018 NNP cord-304472-mi5v6512 164 59 Sentinel Sentinel NNP cord-304472-mi5v6512 164 60 surveillance surveillance NN cord-304472-mi5v6512 164 61 in in IN cord-304472-mi5v6512 164 62 travel travel NN cord-304472-mi5v6512 164 63 medicine medicine NN cord-304472-mi5v6512 164 64 : : : cord-304472-mi5v6512 164 65 20 20 CD cord-304472-mi5v6512 164 66 years year NNS cord-304472-mi5v6512 164 67 of of IN cord-304472-mi5v6512 164 68 GeoSentinel GeoSentinel NNP cord-304472-mi5v6512 164 69 Publications Publications NNPS cord-304472-mi5v6512 164 70 ( ( -LRB- cord-304472-mi5v6512 164 71 1999 1999 CD cord-304472-mi5v6512 164 72 - - SYM cord-304472-mi5v6512 164 73 2018 2018 CD cord-304472-mi5v6512 164 74 ) ) -RRB- cord-304472-mi5v6512 165 1 Illness illness NN cord-304472-mi5v6512 165 2 among among IN cord-304472-mi5v6512 165 3 US US NNP cord-304472-mi5v6512 165 4 resident resident NN cord-304472-mi5v6512 165 5 student student NN cord-304472-mi5v6512 165 6 travellers traveller NNS cord-304472-mi5v6512 165 7 after after IN cord-304472-mi5v6512 165 8 return return NN cord-304472-mi5v6512 165 9 to to IN cord-304472-mi5v6512 165 10 the the DT cord-304472-mi5v6512 165 11 USA USA NNP cord-304472-mi5v6512 165 12 : : : cord-304472-mi5v6512 165 13 a a DT cord-304472-mi5v6512 165 14 GeoSentinel GeoSentinel NNP cord-304472-mi5v6512 165 15 analysis analysis NN cord-304472-mi5v6512 165 16 Business business NN cord-304472-mi5v6512 165 17 travel travel NN cord-304472-mi5v6512 165 18 - - HYPH cord-304472-mi5v6512 165 19 associated associate VBN cord-304472-mi5v6512 165 20 illness illness NN cord-304472-mi5v6512 165 21 : : : cord-304472-mi5v6512 165 22 a a DT cord-304472-mi5v6512 165 23 GeoSentinel GeoSentinel NNP cord-304472-mi5v6512 165 24 analysis analysis NN cord-304472-mi5v6512 165 25 GeoSentinel geosentinel NN cord-304472-mi5v6512 165 26 surveillance surveillance NN cord-304472-mi5v6512 165 27 of of IN cord-304472-mi5v6512 165 28 illness illness NN cord-304472-mi5v6512 165 29 in in IN cord-304472-mi5v6512 165 30 returned return VBN cord-304472-mi5v6512 165 31 travelers traveler NNS cord-304472-mi5v6512 165 32 Illness Illness NNP cord-304472-mi5v6512 165 33 in in IN cord-304472-mi5v6512 165 34 travelers traveler NNS cord-304472-mi5v6512 165 35 visiting visit VBG cord-304472-mi5v6512 165 36 friends friend NNS cord-304472-mi5v6512 165 37 and and CC cord-304472-mi5v6512 165 38 relatives relative NNS cord-304472-mi5v6512 165 39 : : : cord-304472-mi5v6512 165 40 a a DT cord-304472-mi5v6512 165 41 review review NN cord-304472-mi5v6512 165 42 of of IN cord-304472-mi5v6512 165 43 the the DT cord-304472-mi5v6512 165 44 GeoSentinel GeoSentinel NNP cord-304472-mi5v6512 165 45 surveillance surveillance NN cord-304472-mi5v6512 165 46 network network NN cord-304472-mi5v6512 165 47 Dengue dengue NN cord-304472-mi5v6512 165 48 epidemic epidemic NN cord-304472-mi5v6512 165 49 in in IN cord-304472-mi5v6512 165 50 touba touba NNP cord-304472-mi5v6512 165 51 , , , cord-304472-mi5v6512 165 52 senegal senegal NNP cord-304472-mi5v6512 165 53 : : : cord-304472-mi5v6512 165 54 implications implication NNS cord-304472-mi5v6512 165 55 for for IN cord-304472-mi5v6512 165 56 the the DT cord-304472-mi5v6512 165 57 grand grand JJ cord-304472-mi5v6512 165 58 Magal Magal NNP cord-304472-mi5v6512 165 59 pilgrimage pilgrimage NN cord-304472-mi5v6512 165 60 for for IN cord-304472-mi5v6512 165 61 travelers traveler NNS cord-304472-mi5v6512 165 62 Morbidity morbidity NN cord-304472-mi5v6512 165 63 among among IN cord-304472-mi5v6512 165 64 Israeli israeli JJ cord-304472-mi5v6512 165 65 paediatric paediatric JJ cord-304472-mi5v6512 165 66 travellers traveller NNS cord-304472-mi5v6512 166 1 Fatal fatal JJ cord-304472-mi5v6512 166 2 fulminant fulminant JJ cord-304472-mi5v6512 166 3 hepatitis hepatitis NN cord-304472-mi5v6512 166 4 A a NN cord-304472-mi5v6512 166 5 in in IN cord-304472-mi5v6512 166 6 a a DT cord-304472-mi5v6512 166 7 US US NNP cord-304472-mi5v6512 166 8 traveller traveller NN cord-304472-mi5v6512 166 9 returning return VBG cord-304472-mi5v6512 166 10 from from IN cord-304472-mi5v6512 166 11 Peru Peru NNP cord-304472-mi5v6512 166 12 Japanese Japanese NNP cord-304472-mi5v6512 166 13 encephalitis encephalitis RB cord-304472-mi5v6512 166 14 : : : cord-304472-mi5v6512 166 15 vaccine vaccine NN cord-304472-mi5v6512 166 16 options option NNS cord-304472-mi5v6512 166 17 and and CC cord-304472-mi5v6512 166 18 timing timing NN cord-304472-mi5v6512 166 19 of of IN cord-304472-mi5v6512 166 20 pre pre JJ cord-304472-mi5v6512 166 21 - - JJ cord-304472-mi5v6512 166 22 travel travel JJ cord-304472-mi5v6512 166 23 vaccination vaccination NN cord-304472-mi5v6512 166 24 Recent recent JJ cord-304472-mi5v6512 166 25 and and CC cord-304472-mi5v6512 166 26 historical historical JJ cord-304472-mi5v6512 166 27 trends trend NNS cord-304472-mi5v6512 166 28 in in IN cord-304472-mi5v6512 166 29 the the DT cord-304472-mi5v6512 166 30 epidemiology epidemiology NN cord-304472-mi5v6512 166 31 of of IN cord-304472-mi5v6512 166 32 Japanese japanese JJ cord-304472-mi5v6512 166 33 encephalitis encephaliti NNS cord-304472-mi5v6512 166 34 and and CC cord-304472-mi5v6512 166 35 its -PRON- PRP$ cord-304472-mi5v6512 166 36 implication implication NN cord-304472-mi5v6512 166 37 for for IN cord-304472-mi5v6512 166 38 risk risk NN cord-304472-mi5v6512 166 39 assessment assessment NN cord-304472-mi5v6512 166 40 in in IN cord-304472-mi5v6512 166 41 travellers traveller NNS cord-304472-mi5v6512 167 1 What what WP cord-304472-mi5v6512 167 2 is be VBZ cord-304472-mi5v6512 167 3 the the DT cord-304472-mi5v6512 167 4 prospect prospect NN cord-304472-mi5v6512 167 5 of of IN cord-304472-mi5v6512 167 6 a a DT cord-304472-mi5v6512 167 7 safe safe JJ cord-304472-mi5v6512 167 8 and and CC cord-304472-mi5v6512 167 9 effective effective JJ cord-304472-mi5v6512 167 10 dengue dengue NN cord-304472-mi5v6512 167 11 vaccine vaccine NN cord-304472-mi5v6512 167 12 for for IN cord-304472-mi5v6512 167 13 travellers traveller NNS cord-304472-mi5v6512 167 14 ? ? . cord-304472-mi5v6512 168 1 Mosquito mosquito NN cord-304472-mi5v6512 168 2 repellents repellent NNS cord-304472-mi5v6512 168 3 for for IN cord-304472-mi5v6512 168 4 the the DT cord-304472-mi5v6512 168 5 traveller traveller NN cord-304472-mi5v6512 168 6 : : : cord-304472-mi5v6512 168 7 does do VBZ cord-304472-mi5v6512 168 8 picaridin picaridin NNS cord-304472-mi5v6512 168 9 provide provide VB cord-304472-mi5v6512 168 10 longer long JJR cord-304472-mi5v6512 168 11 protection protection NN cord-304472-mi5v6512 168 12 than than IN cord-304472-mi5v6512 168 13 DEET DEET NNP cord-304472-mi5v6512 168 14 ? ? . cord-304472-mi5v6512 169 1 Factors factor NNS cord-304472-mi5v6512 169 2 affecting affect VBG cord-304472-mi5v6512 169 3 pre pre JJ cord-304472-mi5v6512 169 4 - - JJ cord-304472-mi5v6512 169 5 travel travel JJ cord-304472-mi5v6512 169 6 health health NN cord-304472-mi5v6512 169 7 seeking seek VBG cord-304472-mi5v6512 169 8 behaviour behaviour NN cord-304472-mi5v6512 169 9 and and CC cord-304472-mi5v6512 169 10 adherence adherence NN cord-304472-mi5v6512 169 11 to to IN cord-304472-mi5v6512 169 12 pre pre VB cord-304472-mi5v6512 169 13 - - VB cord-304472-mi5v6512 169 14 travel travel VB cord-304472-mi5v6512 169 15 health health NN cord-304472-mi5v6512 169 16 advice advice NN cord-304472-mi5v6512 169 17 : : : cord-304472-mi5v6512 169 18 a a DT cord-304472-mi5v6512 169 19 systematic systematic JJ cord-304472-mi5v6512 169 20 review review NN cord-304472-mi5v6512 169 21 Sequential sequential JJ cord-304472-mi5v6512 169 22 immunization immunization NN cord-304472-mi5v6512 169 23 induces induce VBZ cord-304472-mi5v6512 169 24 strong strong JJ cord-304472-mi5v6512 169 25 and and CC cord-304472-mi5v6512 169 26 broad broad JJ cord-304472-mi5v6512 169 27 immunity immunity NN cord-304472-mi5v6512 169 28 against against IN cord-304472-mi5v6512 169 29 all all DT cord-304472-mi5v6512 169 30 four four CD cord-304472-mi5v6512 169 31 dengue dengue NN cord-304472-mi5v6512 169 32 virus virus NN cord-304472-mi5v6512 169 33 serotypes serotype NNS cord-304472-mi5v6512 169 34 Combine combine VBP cord-304472-mi5v6512 169 35 dengue dengue NN cord-304472-mi5v6512 169 36 vaccines vaccine NNS cord-304472-mi5v6512 169 37 to to TO cord-304472-mi5v6512 169 38 optimize optimize VB cord-304472-mi5v6512 169 39 effectiveness effectiveness NN cord-304472-mi5v6512 170 1 This this DT cord-304472-mi5v6512 170 2 is be VBZ cord-304472-mi5v6512 170 3 an an DT cord-304472-mi5v6512 170 4 opinion opinion NN cord-304472-mi5v6512 170 5 paper paper NN cord-304472-mi5v6512 170 6 that that WDT cord-304472-mi5v6512 170 7 discusses discuss VBZ cord-304472-mi5v6512 170 8 heterologous heterologous JJ cord-304472-mi5v6512 170 9 prime prime JJ cord-304472-mi5v6512 170 10 - - HYPH cord-304472-mi5v6512 170 11 boost boost NN cord-304472-mi5v6512 170 12 strategy strategy NN cord-304472-mi5v6512 170 13 by by IN cord-304472-mi5v6512 170 14 giving give VBG cord-304472-mi5v6512 170 15 Takeda Takeda NNP cord-304472-mi5v6512 170 16 's 's POS cord-304472-mi5v6512 170 17 TAK-003 tak-003 NN cord-304472-mi5v6512 170 18 first first RB cord-304472-mi5v6512 170 19 followed follow VBN cord-304472-mi5v6512 170 20 by by IN cord-304472-mi5v6512 170 21 Sanofi Sanofi NNP cord-304472-mi5v6512 170 22 Pasteur Pasteur NNP cord-304472-mi5v6512 170 23 's 's POS cord-304472-mi5v6512 170 24 CYD CYD NNP cord-304472-mi5v6512 170 25 - - HYPH cord-304472-mi5v6512 170 26 TDV TDV NNP cord-304472-mi5v6512 170 27 Status status NN cord-304472-mi5v6512 170 28 of of IN cord-304472-mi5v6512 170 29 current current JJ cord-304472-mi5v6512 170 30 and and CC cord-304472-mi5v6512 170 31 under under IN cord-304472-mi5v6512 170 32 - - HYPH cord-304472-mi5v6512 170 33 development development NN cord-304472-mi5v6512 170 34 vaccines vaccine NNS cord-304472-mi5v6512 170 35 Phase Phase NNP cord-304472-mi5v6512 170 36 1 1 CD cord-304472-mi5v6512 170 37 randomized randomized JJ cord-304472-mi5v6512 170 38 study study NN cord-304472-mi5v6512 170 39 of of IN cord-304472-mi5v6512 170 40 a a DT cord-304472-mi5v6512 170 41 tetravalent tetravalent NN cord-304472-mi5v6512 170 42 dengue dengue NN cord-304472-mi5v6512 170 43 purified purify VBN cord-304472-mi5v6512 170 44 inactivated inactivate VBN cord-304472-mi5v6512 170 45 vaccine vaccine NN cord-304472-mi5v6512 170 46 in in IN cord-304472-mi5v6512 170 47 healthy healthy JJ cord-304472-mi5v6512 170 48 adults adult NNS cord-304472-mi5v6512 170 49 in in IN cord-304472-mi5v6512 170 50 the the DT cord-304472-mi5v6512 170 51 United United NNP cord-304472-mi5v6512 170 52 States States NNP cord-304472-mi5v6512 170 53 Phase Phase NNP cord-304472-mi5v6512 170 54 I -PRON- PRP cord-304472-mi5v6512 170 55 randomized randomize VBD cord-304472-mi5v6512 170 56 study study NN cord-304472-mi5v6512 170 57 of of IN cord-304472-mi5v6512 170 58 a a DT cord-304472-mi5v6512 170 59 tetravalent tetravalent NN cord-304472-mi5v6512 170 60 dengue dengue NN cord-304472-mi5v6512 170 61 Dengue Dengue NNP cord-304472-mi5v6512 170 62 vaccine vaccine NN cord-304472-mi5v6512 170 63 development development NN cord-304472-mi5v6512 170 64 Wilder Wilder NNP cord-304472-mi5v6512 170 65 purified purify VBN cord-304472-mi5v6512 170 66 inactivated inactivated JJ cord-304472-mi5v6512 170 67 vaccine vaccine NN cord-304472-mi5v6512 170 68 in in IN cord-304472-mi5v6512 170 69 healthy healthy JJ cord-304472-mi5v6512 170 70 adults adult NNS cord-304472-mi5v6512 170 71 from from IN cord-304472-mi5v6512 170 72 Puerto Puerto NNP cord-304472-mi5v6512 170 73 Rico Rico NNP cord-304472-mi5v6512 170 74 Dengue Dengue NNP cord-304472-mi5v6512 170 75 , , , cord-304472-mi5v6512 170 76 Zika Zika NNP cord-304472-mi5v6512 170 77 and and CC cord-304472-mi5v6512 170 78 chikungunya chikungunya NN cord-304472-mi5v6512 170 79 during during IN cord-304472-mi5v6512 170 80 pregnancy pregnancy NN cord-304472-mi5v6512 170 81 : : : cord-304472-mi5v6512 171 1 preand preand NNP cord-304472-mi5v6512 171 2 post post JJ cord-304472-mi5v6512 171 3 - - JJ cord-304472-mi5v6512 171 4 travel travel JJ cord-304472-mi5v6512 171 5 advice advice NN cord-304472-mi5v6512 171 6 and and CC cord-304472-mi5v6512 171 7 clinical clinical JJ cord-304472-mi5v6512 171 8 management management NN cord-304472-mi5v6512 171 9 A a NN cord-304472-mi5v6512 171 10 : : : cord-304472-mi5v6512 171 11 Can Can MD cord-304472-mi5v6512 171 12 dengue dengue VB cord-304472-mi5v6512 171 13 virus virus NN cord-304472-mi5v6512 171 14 be be VB cord-304472-mi5v6512 171 15 sexually sexually RB cord-304472-mi5v6512 171 16 transmitted transmit VBN cord-304472-mi5v6512 171 17 ? ? . cord-304472-mi5v6512 172 1 Dengue dengue NN cord-304472-mi5v6512 172 2 virus virus NN cord-304472-mi5v6512 172 3 not not RB cord-304472-mi5v6512 172 4 detected detect VBN cord-304472-mi5v6512 172 5 in in IN cord-304472-mi5v6512 172 6 human human JJ cord-304472-mi5v6512 172 7 semen semen NN cord-304472-mi5v6512 172 8 Incidence incidence NN cord-304472-mi5v6512 172 9 of of IN cord-304472-mi5v6512 172 10 Guillain Guillain NNP cord-304472-mi5v6512 172 11 - - HYPH cord-304472-mi5v6512 172 12 Barre Barre NNP cord-304472-mi5v6512 172 13 Syndrome Syndrome NNP cord-304472-mi5v6512 172 14 ( ( -LRB- cord-304472-mi5v6512 172 15 GBS GBS NNP cord-304472-mi5v6512 172 16 ) ) -RRB- cord-304472-mi5v6512 172 17 in in IN cord-304472-mi5v6512 172 18 Latin Latin NNP cord-304472-mi5v6512 172 19 America America NNP cord-304472-mi5v6512 172 20 and and CC cord-304472-mi5v6512 172 21 the the DT cord-304472-mi5v6512 172 22 Caribbean Caribbean NNP cord-304472-mi5v6512 172 23 before before RB cord-304472-mi5v6512 172 24 and and CC cord-304472-mi5v6512 172 25 during during IN cord-304472-mi5v6512 172 26 the the DT cord-304472-mi5v6512 172 27 2015 2015 CD cord-304472-mi5v6512 172 28 - - SYM cord-304472-mi5v6512 172 29 2016 2016 CD cord-304472-mi5v6512 172 30 Zika Zika NNP cord-304472-mi5v6512 172 31 virus virus NN cord-304472-mi5v6512 172 32 epidemic epidemic NN cord-304472-mi5v6512 172 33 : : : cord-304472-mi5v6512 172 34 a a DT cord-304472-mi5v6512 172 35 systematic systematic JJ cord-304472-mi5v6512 172 36 review review NN cord-304472-mi5v6512 172 37 and and CC cord-304472-mi5v6512 172 38 meta meta NNP cord-304472-mi5v6512 172 39 - - HYPH cord-304472-mi5v6512 172 40 analysis analysis NN cord-304472-mi5v6512 172 41 Recombination Recombination NNP cord-304472-mi5v6512 172 42 of of IN cord-304472-mi5v6512 172 43 B B NNP cord-304472-mi5v6512 172 44 - - : cord-304472-mi5v6512 172 45 and and CC cord-304472-mi5v6512 172 46 T t NN cord-304472-mi5v6512 172 47 - - HYPH cord-304472-mi5v6512 172 48 cell cell NN cord-304472-mi5v6512 172 49 epitoperich epitoperich NNP cord-304472-mi5v6512 172 50 loci locus NNS cord-304472-mi5v6512 172 51 from from IN cord-304472-mi5v6512 172 52 Aedes Aedes NNP cord-304472-mi5v6512 172 53 - - : cord-304472-mi5v6512 172 54 and and CC cord-304472-mi5v6512 172 55 Culex Culex NNP cord-304472-mi5v6512 172 56 - - HYPH cord-304472-mi5v6512 172 57 borne bear VBN cord-304472-mi5v6512 172 58 flaviviruses flavivirus NNS cord-304472-mi5v6512 172 59 shapes shape NNS cord-304472-mi5v6512 173 1 Zika Zika NNP cord-304472-mi5v6512 173 2 virus virus NN cord-304472-mi5v6512 173 3 epidemiology epidemiology NN cord-304472-mi5v6512 173 4 Comprehensive comprehensive JJ cord-304472-mi5v6512 173 5 immunoprofiling immunoprofiling NN cord-304472-mi5v6512 173 6 of of IN cord-304472-mi5v6512 173 7 pediatric pediatric JJ cord-304472-mi5v6512 173 8 Zika Zika NNP cord-304472-mi5v6512 173 9 reveals reveal VBZ cord-304472-mi5v6512 173 10 key key JJ cord-304472-mi5v6512 173 11 role role NN cord-304472-mi5v6512 173 12 for for IN cord-304472-mi5v6512 173 13 monocytes monocyte NNS cord-304472-mi5v6512 173 14 in in IN cord-304472-mi5v6512 173 15 the the DT cord-304472-mi5v6512 173 16 acute acute JJ cord-304472-mi5v6512 173 17 phase phase NN cord-304472-mi5v6512 173 18 and and CC cord-304472-mi5v6512 173 19 no no DT cord-304472-mi5v6512 173 20 effect effect NN cord-304472-mi5v6512 173 21 of of IN cord-304472-mi5v6512 173 22 prior prior JJ cord-304472-mi5v6512 173 23 dengue dengue NN cord-304472-mi5v6512 173 24 virus virus NN cord-304472-mi5v6512 173 25 infection infection NN cord-304472-mi5v6512 173 26 Primary primary JJ cord-304472-mi5v6512 173 27 and and CC cord-304472-mi5v6512 173 28 secondary secondary JJ cord-304472-mi5v6512 173 29 dengue dengue NN cord-304472-mi5v6512 173 30 virus virus NN cord-304472-mi5v6512 173 31 infections infection NNS cord-304472-mi5v6512 173 32 elicit elicit VBP cord-304472-mi5v6512 173 33 similar similar JJ cord-304472-mi5v6512 173 34 memory memory NN cord-304472-mi5v6512 173 35 B b NN cord-304472-mi5v6512 173 36 - - HYPH cord-304472-mi5v6512 173 37 Cell cell NN cord-304472-mi5v6512 173 38 responses response NNS cord-304472-mi5v6512 173 39 , , , cord-304472-mi5v6512 173 40 but but CC cord-304472-mi5v6512 173 41 breadth breadth NN cord-304472-mi5v6512 173 42 to to IN cord-304472-mi5v6512 173 43 other other JJ cord-304472-mi5v6512 173 44 serotypes serotype NNS cord-304472-mi5v6512 173 45 and and CC cord-304472-mi5v6512 173 46 cross cross NN cord-304472-mi5v6512 173 47 - - NN cord-304472-mi5v6512 173 48 reactivity reactivity NN cord-304472-mi5v6512 173 49 to to IN cord-304472-mi5v6512 173 50 Zika Zika NNP cord-304472-mi5v6512 173 51 virus virus NN cord-304472-mi5v6512 173 52 is be VBZ cord-304472-mi5v6512 173 53 higher high JJR cord-304472-mi5v6512 173 54 in in IN cord-304472-mi5v6512 173 55 secondary secondary JJ cord-304472-mi5v6512 173 56 dengue dengue NN cord-304472-mi5v6512 173 57 Laboratory Laboratory NNP cord-304472-mi5v6512 173 58 study study NN cord-304472-mi5v6512 173 59 that that WDT cord-304472-mi5v6512 173 60 investigates investigate VBZ cord-304472-mi5v6512 173 61 the the DT cord-304472-mi5v6512 173 62 role role NN cord-304472-mi5v6512 173 63 of of IN cord-304472-mi5v6512 173 64 prior prior JJ cord-304472-mi5v6512 173 65 dengue dengue NN cord-304472-mi5v6512 173 66 infections infection NNS cord-304472-mi5v6512 173 67 on on IN cord-304472-mi5v6512 173 68 the the DT cord-304472-mi5v6512 173 69 immune immune JJ cord-304472-mi5v6512 173 70 response response NN cord-304472-mi5v6512 173 71 Impact Impact NNP cord-304472-mi5v6512 173 72 of of IN cord-304472-mi5v6512 173 73 pre pre JJ cord-304472-mi5v6512 173 74 - - JJ cord-304472-mi5v6512 173 75 existing existing JJ cord-304472-mi5v6512 173 76 dengue dengue NN cord-304472-mi5v6512 173 77 immunity immunity NN cord-304472-mi5v6512 173 78 on on IN cord-304472-mi5v6512 173 79 human human JJ cord-304472-mi5v6512 173 80 antibody antibody NN cord-304472-mi5v6512 173 81 and and CC cord-304472-mi5v6512 173 82 memory memory NN cord-304472-mi5v6512 173 83 B b NN cord-304472-mi5v6512 173 84 cell cell NN cord-304472-mi5v6512 173 85 responses response NNS cord-304472-mi5v6512 173 86 to to IN cord-304472-mi5v6512 173 87 Zika Zika NNP cord-304472-mi5v6512 173 88 Impact Impact NNP cord-304472-mi5v6512 173 89 of of IN cord-304472-mi5v6512 173 90 preexisting preexist VBG cord-304472-mi5v6512 173 91 dengue dengue NN cord-304472-mi5v6512 173 92 immunity immunity NN cord-304472-mi5v6512 173 93 on on IN cord-304472-mi5v6512 173 94 Zika Zika NNP cord-304472-mi5v6512 173 95 virus virus NN cord-304472-mi5v6512 173 96 emergence emergence NN cord-304472-mi5v6512 173 97 in in IN cord-304472-mi5v6512 173 98 a a DT cord-304472-mi5v6512 173 99 dengue dengue NN cord-304472-mi5v6512 173 100 endemic endemic JJ cord-304472-mi5v6512 173 101 region region NN cord-304472-mi5v6512 174 1 This this DT cord-304472-mi5v6512 174 2 paper paper NN cord-304472-mi5v6512 174 3 discusses discuss VBZ cord-304472-mi5v6512 174 4 the the DT cord-304472-mi5v6512 174 5 immunological immunological JJ cord-304472-mi5v6512 174 6 interaction interaction NN cord-304472-mi5v6512 174 7 between between IN cord-304472-mi5v6512 174 8 Zika Zika NNP cord-304472-mi5v6512 174 9 and and CC cord-304472-mi5v6512 174 10 dengue dengue NN cord-304472-mi5v6512 174 11 viruses virus NNS cord-304472-mi5v6512 174 12 Co co NN cord-304472-mi5v6512 174 13 - - NN cord-304472-mi5v6512 174 14 infection infection NN cord-304472-mi5v6512 174 15 between between IN cord-304472-mi5v6512 174 16 Zika Zika NNP cord-304472-mi5v6512 174 17 and and CC cord-304472-mi5v6512 174 18 different different JJ cord-304472-mi5v6512 174 19 Dengue dengue NN cord-304472-mi5v6512 174 20 serotypes serotype NNS cord-304472-mi5v6512 174 21 during during IN cord-304472-mi5v6512 174 22 DENV DENV NNP cord-304472-mi5v6512 174 23 outbreak outbreak NN cord-304472-mi5v6512 174 24 in in IN cord-304472-mi5v6512 174 25 Brazil Brazil NNP cord-304472-mi5v6512 174 26 COVID-19 COVID-19 NNP cord-304472-mi5v6512 174 27 and and CC cord-304472-mi5v6512 174 28 dengue dengue NN cord-304472-mi5v6512 174 29 co co NN cord-304472-mi5v6512 174 30 - - NN cord-304472-mi5v6512 174 31 infection infection NN cord-304472-mi5v6512 174 32 in in IN cord-304472-mi5v6512 174 33 a a DT cord-304472-mi5v6512 174 34 returning return VBG cord-304472-mi5v6512 174 35 traveller traveller NN cord-304472-mi5v6512 174 36 Preventing prevent VBG cord-304472-mi5v6512 174 37 dengue dengue NN cord-304472-mi5v6512 174 38 epidemics epidemic NNS cord-304472-mi5v6512 174 39 during during IN cord-304472-mi5v6512 174 40 the the DT cord-304472-mi5v6512 174 41 COVID-19 COVID-19 NNP cord-304472-mi5v6512 174 42 pandemic pandemic NN cord-304472-mi5v6512 175 1 Nothing nothing NN cord-304472-mi5v6512 175 2 declared declare VBD cord-304472-mi5v6512 175 3 . . . cord-304472-mi5v6512 176 1 Disclaimer Disclaimer NNP cord-304472-mi5v6512 176 2 AWS AWS NNP cord-304472-mi5v6512 176 3 serves serve VBZ cord-304472-mi5v6512 176 4 as as IN cord-304472-mi5v6512 176 5 consultant consultant NN cord-304472-mi5v6512 176 6 to to IN cord-304472-mi5v6512 176 7 the the DT cord-304472-mi5v6512 176 8 World World NNP cord-304472-mi5v6512 176 9 Health Health NNP cord-304472-mi5v6512 176 10 Organization Organization NNP cord-304472-mi5v6512 176 11 with with IN cord-304472-mi5v6512 176 12 regards regard NNS cord-304472-mi5v6512 176 13 to to IN cord-304472-mi5v6512 176 14 dengue dengue NN cord-304472-mi5v6512 176 15 vaccines vaccine NNS cord-304472-mi5v6512 176 16 . . . cord-304472-mi5v6512 177 1 The the DT cord-304472-mi5v6512 177 2 views view NNS cord-304472-mi5v6512 177 3 expressed express VBN cord-304472-mi5v6512 177 4 in in IN cord-304472-mi5v6512 177 5 this this DT cord-304472-mi5v6512 177 6 article article NN cord-304472-mi5v6512 177 7 are be VBP cord-304472-mi5v6512 177 8 those those DT cord-304472-mi5v6512 177 9 of of IN cord-304472-mi5v6512 177 10 the the DT cord-304472-mi5v6512 177 11 author author NN cord-304472-mi5v6512 177 12 and and CC cord-304472-mi5v6512 177 13 do do VBP cord-304472-mi5v6512 177 14 not not RB cord-304472-mi5v6512 177 15 necessarily necessarily RB cord-304472-mi5v6512 177 16 represent represent VB cord-304472-mi5v6512 177 17 the the DT cord-304472-mi5v6512 177 18 decisions decision NNS cord-304472-mi5v6512 177 19 or or CC cord-304472-mi5v6512 177 20 policies policy NNS cord-304472-mi5v6512 177 21 of of IN cord-304472-mi5v6512 177 22 the the DT cord-304472-mi5v6512 177 23 World World NNP cord-304472-mi5v6512 177 24 Health Health NNP cord-304472-mi5v6512 177 25 Organization Organization NNP cord-304472-mi5v6512 177 26 . . . cord-304472-mi5v6512 177 27 _SP