id	sid	tid	token	lemma	pos
cord-267897-w4pbq2lb	1	1	key	key	NN
cord-267897-w4pbq2lb	1	2	:	:	:
cord-267897-w4pbq2lb	2	1	cord-267897-w4pbq2	cord-267897-w4pbq2	CD
cord-267897-w4pbq2lb	2	2	lb	lb	CD
cord-267897-w4pbq2lb	2	3	authors	author	NNS
cord-267897-w4pbq2lb	2	4	:	:	:
cord-267897-w4pbq2lb	2	5	Lindblad	Lindblad	NNP
cord-267897-w4pbq2lb	2	6	,	,	,
cord-267897-w4pbq2lb	2	7	E.	E.	NNP
cord-267897-w4pbq2lb	2	8	B.	B.	NNP
cord-267897-w4pbq2lb	2	9	;	;	:
cord-267897-w4pbq2lb	2	10	Duroux	Duroux	NNP
cord-267897-w4pbq2lb	2	11	,	,	,
cord-267897-w4pbq2lb	2	12	L.	L.	NNP
cord-267897-w4pbq2lb	2	13	title	title	NN
cord-267897-w4pbq2lb	2	14	:	:	:
cord-267897-w4pbq2lb	2	15	Chapter	chapter	NN
cord-267897-w4pbq2lb	2	16	18	18	CD
cord-267897-w4pbq2lb	2	17	Mineral	Mineral	NNP
cord-267897-w4pbq2lb	2	18	Adjuvants	Adjuvants	NNPS
cord-267897-w4pbq2lb	2	19	∗	∗	NNP
cord-267897-w4pbq2lb	2	20	∗	∗	NNP
cord-267897-w4pbq2lb	3	1	The	the	DT
cord-267897-w4pbq2lb	3	2	present	present	JJ
cord-267897-w4pbq2lb	3	3	chapter	chapter	NN
cord-267897-w4pbq2lb	3	4	is	be	VBZ
cord-267897-w4pbq2lb	3	5	an	an	DT
cord-267897-w4pbq2lb	3	6	updated	update	VBN
cord-267897-w4pbq2lb	3	7	version	version	NN
cord-267897-w4pbq2lb	3	8	of	of	IN
cord-267897-w4pbq2lb	3	9	the	the	DT
cord-267897-w4pbq2lb	3	10	chapter	chapter	NN
cord-267897-w4pbq2lb	3	11	“	"	``
cord-267897-w4pbq2lb	3	12	Mineral	Mineral	NNP
cord-267897-w4pbq2lb	3	13	Adjuvants	Adjuvants	NNPS
cord-267897-w4pbq2lb	3	14	,	,	,
cord-267897-w4pbq2lb	3	15	”	"	''
cord-267897-w4pbq2lb	3	16	published	publish	VBN
cord-267897-w4pbq2lb	3	17	in	in	IN
cord-267897-w4pbq2lb	3	18	Immunopotentiators	Immunopotentiators	NNP
cord-267897-w4pbq2lb	3	19	in	in	IN
cord-267897-w4pbq2lb	3	20	Modern	Modern	NNP
cord-267897-w4pbq2lb	3	21	Vaccines	Vaccines	NNPS
cord-267897-w4pbq2lb	3	22	,	,	,
cord-267897-w4pbq2lb	4	1	p.	p.	NN
cord-267897-w4pbq2lb	4	2	217–233	217–233	CD
cord-267897-w4pbq2lb	4	3	.	.	.
cord-267897-w4pbq2lb	5	1	Ed	Ed	NNP
cord-267897-w4pbq2lb	5	2	.	.	.
cord-267897-w4pbq2lb	6	1	Virgil	Virgil	NNP
cord-267897-w4pbq2lb	6	2	Schijns	Schijns	NNP
cord-267897-w4pbq2lb	6	3	&	&	CC
cord-267897-w4pbq2lb	6	4	Derek	Derek	NNP
cord-267897-w4pbq2lb	6	5	O'Hagan	O'Hagan	NNP
cord-267897-w4pbq2lb	6	6	,	,	,
cord-267897-w4pbq2lb	6	7	Elsevier	Elsevier	NNP
cord-267897-w4pbq2lb	6	8	Science	Science	NNP
cord-267897-w4pbq2lb	6	9	Publishers	Publishers	NNPS
cord-267897-w4pbq2lb	6	10	(	(	-LRB-
cord-267897-w4pbq2lb	6	11	2005	2005	CD
cord-267897-w4pbq2lb	6	12	)	)	-RRB-
cord-267897-w4pbq2lb	6	13	.	.	.
cord-267897-w4pbq2lb	7	1	date	date	NN
cord-267897-w4pbq2lb	7	2	:	:	:
cord-267897-w4pbq2lb	7	3	2017	2017	CD
cord-267897-w4pbq2lb	7	4	-	-	HYPH
cord-267897-w4pbq2lb	7	5	12	12	CD
cord-267897-w4pbq2lb	7	6	-	-	SYM
cord-267897-w4pbq2lb	7	7	31	31	CD
cord-267897-w4pbq2lb	7	8	journal	journal	NN
cord-267897-w4pbq2lb	7	9	:	:	:
cord-267897-w4pbq2lb	7	10	Immunopotentiators	Immunopotentiators	NNP
cord-267897-w4pbq2lb	7	11	in	in	IN
cord-267897-w4pbq2lb	7	12	Modern	modern	JJ
cord-267897-w4pbq2lb	7	13	Vaccines	Vaccines	NNPS
cord-267897-w4pbq2lb	7	14	DOI	DOI	NNP
cord-267897-w4pbq2lb	7	15	:	:	:
cord-267897-w4pbq2lb	7	16	10.1016	10.1016	CD
cord-267897-w4pbq2lb	7	17	/	/	SYM
cord-267897-w4pbq2lb	7	18	b978	b978	NN
cord-267897-w4pbq2lb	7	19	-	-	HYPH
cord-267897-w4pbq2lb	7	20	0	0	CD
cord-267897-w4pbq2lb	7	21	-	-	HYPH
cord-267897-w4pbq2lb	7	22	12	12	CD
cord-267897-w4pbq2lb	7	23	-	-	HYPH
cord-267897-w4pbq2lb	7	24	804019	804019	CD
cord-267897-w4pbq2lb	7	25	-	-	HYPH
cord-267897-w4pbq2lb	7	26	5.00018	5.00018	CD
cord-267897-w4pbq2lb	7	27	-	-	SYM
cord-267897-w4pbq2lb	7	28	9	9	CD
cord-267897-w4pbq2lb	7	29	sha	sha	NN
cord-267897-w4pbq2lb	7	30	:	:	:
cord-267897-w4pbq2lb	8	1	c3116b5f9a9a500febbe20c50a770d958fb42188	c3116b5f9a9a500febbe20c50a770d958fb42188	NNP
cord-267897-w4pbq2lb	8	2	doc_id	doc_id	CD
cord-267897-w4pbq2lb	8	3	:	:	:
cord-267897-w4pbq2lb	8	4	267897	267897	CD
cord-267897-w4pbq2lb	8	5	cord_uid	cord_uid	NNS
cord-267897-w4pbq2lb	8	6	:	:	:
cord-267897-w4pbq2lb	9	1	w4pbq2	w4pbq2	:
cord-267897-w4pbq2lb	9	2	lb	lb	NNP
cord-267897-w4pbq2lb	9	3	Abstract	Abstract	NNP
cord-267897-w4pbq2lb	9	4	Mineral	Mineral	NNP
cord-267897-w4pbq2lb	9	5	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	9	6	comprise	comprise	VBP
cord-267897-w4pbq2lb	9	7	aluminum	aluminum	VBP
cord-267897-w4pbq2lb	9	8	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	9	9	and	and	CC
cord-267897-w4pbq2lb	9	10	phosphate	phosphate	NN
cord-267897-w4pbq2lb	9	11	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	9	12	as	as	RB
cord-267897-w4pbq2lb	9	13	well	well	RB
cord-267897-w4pbq2lb	9	14	as	as	IN
cord-267897-w4pbq2lb	9	15	calcium	calcium	NN
cord-267897-w4pbq2lb	9	16	phosphate	phosphate	NN
cord-267897-w4pbq2lb	9	17	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	9	18	.	.	.
cord-267897-w4pbq2lb	10	1	In	in	IN
cord-267897-w4pbq2lb	10	2	particular	particular	JJ
cord-267897-w4pbq2lb	10	3	,	,	,
cord-267897-w4pbq2lb	10	4	the	the	DT
cord-267897-w4pbq2lb	10	5	aluminum	aluminum	NN
cord-267897-w4pbq2lb	10	6	salts	salt	NNS
cord-267897-w4pbq2lb	10	7	have	have	VBP
cord-267897-w4pbq2lb	10	8	achieved	achieve	VBN
cord-267897-w4pbq2lb	10	9	an	an	DT
cord-267897-w4pbq2lb	10	10	undisputed	undisputed	JJ
cord-267897-w4pbq2lb	10	11	status	status	NN
cord-267897-w4pbq2lb	10	12	as	as	IN
cord-267897-w4pbq2lb	10	13	the	the	DT
cord-267897-w4pbq2lb	10	14	most	most	RBS
cord-267897-w4pbq2lb	10	15	commonly	commonly	RB
cord-267897-w4pbq2lb	10	16	used	use	VBN
cord-267897-w4pbq2lb	10	17	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	10	18	in	in	IN
cord-267897-w4pbq2lb	10	19	human	human	JJ
cord-267897-w4pbq2lb	10	20	and	and	CC
cord-267897-w4pbq2lb	10	21	veterinary	veterinary	JJ
cord-267897-w4pbq2lb	10	22	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	10	23	.	.	.
cord-267897-w4pbq2lb	11	1	Calcium	calcium	NN
cord-267897-w4pbq2lb	11	2	phosphate	phosphate	NN
cord-267897-w4pbq2lb	11	3	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	11	4	,	,	,
cord-267897-w4pbq2lb	11	5	later	later	RB
cord-267897-w4pbq2lb	11	6	discovered	discover	VBN
cord-267897-w4pbq2lb	11	7	by	by	IN
cord-267897-w4pbq2lb	11	8	Edgar	Edgar	NNP
cord-267897-w4pbq2lb	11	9	Relyveld	Relyveld	NNP
cord-267897-w4pbq2lb	11	10	,	,	,
cord-267897-w4pbq2lb	11	11	constitutes	constitute	VBZ
cord-267897-w4pbq2lb	11	12	a	a	DT
cord-267897-w4pbq2lb	11	13	very	very	RB
cord-267897-w4pbq2lb	11	14	interesting	interesting	JJ
cord-267897-w4pbq2lb	11	15	alternative	alternative	NN
cord-267897-w4pbq2lb	11	16	and	and	CC
cord-267897-w4pbq2lb	11	17	has	have	VBZ
cord-267897-w4pbq2lb	11	18	also	also	RB
cord-267897-w4pbq2lb	11	19	been	be	VBN
cord-267897-w4pbq2lb	11	20	applied	apply	VBN
cord-267897-w4pbq2lb	11	21	both	both	CC
cord-267897-w4pbq2lb	11	22	in	in	IN
cord-267897-w4pbq2lb	11	23	human	human	JJ
cord-267897-w4pbq2lb	11	24	and	and	CC
cord-267897-w4pbq2lb	11	25	veterinary	veterinary	JJ
cord-267897-w4pbq2lb	11	26	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	11	27	.	.	.
cord-267897-w4pbq2lb	12	1	New	new	JJ
cord-267897-w4pbq2lb	12	2	analytical	analytical	JJ
cord-267897-w4pbq2lb	12	3	tools	tool	NNS
cord-267897-w4pbq2lb	12	4	applied	apply	VBN
cord-267897-w4pbq2lb	12	5	in	in	IN
cord-267897-w4pbq2lb	12	6	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	12	7	research	research	NN
cord-267897-w4pbq2lb	12	8	are	be	VBP
cord-267897-w4pbq2lb	12	9	about	about	JJ
cord-267897-w4pbq2lb	12	10	to	to	TO
cord-267897-w4pbq2lb	12	11	take	take	VB
cord-267897-w4pbq2lb	12	12	us	-PRON-	PRP
cord-267897-w4pbq2lb	12	13	to	to	IN
cord-267897-w4pbq2lb	12	14	the	the	DT
cord-267897-w4pbq2lb	12	15	next	next	JJ
cord-267897-w4pbq2lb	12	16	level	level	NN
cord-267897-w4pbq2lb	12	17	of	of	IN
cord-267897-w4pbq2lb	12	18	understanding	understand	VBG
cord-267897-w4pbq2lb	12	19	mineral	mineral	NN
cord-267897-w4pbq2lb	12	20	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	12	21	.	.	.
cord-267897-w4pbq2lb	13	1	These	these	DT
cord-267897-w4pbq2lb	13	2	tools	tool	NNS
cord-267897-w4pbq2lb	13	3	have	have	VBP
cord-267897-w4pbq2lb	13	4	been	be	VBN
cord-267897-w4pbq2lb	13	5	used	use	VBN
cord-267897-w4pbq2lb	13	6	to	to	TO
cord-267897-w4pbq2lb	13	7	characterize	characterize	VB
cord-267897-w4pbq2lb	13	8	mineral	mineral	NN
cord-267897-w4pbq2lb	13	9	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	13	10	,	,	,
cord-267897-w4pbq2lb	13	11	but	but	CC
cord-267897-w4pbq2lb	13	12	so	so	RB
cord-267897-w4pbq2lb	13	13	far	far	RB
cord-267897-w4pbq2lb	13	14	,	,	,
cord-267897-w4pbq2lb	13	15	in	in	IN
cord-267897-w4pbq2lb	13	16	particular	particular	JJ
cord-267897-w4pbq2lb	13	17	,	,	,
cord-267897-w4pbq2lb	13	18	aluminum	aluminum	NN
cord-267897-w4pbq2lb	13	19	-	-	HYPH
cord-267897-w4pbq2lb	13	20	based	base	VBN
cord-267897-w4pbq2lb	13	21	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	13	22	in	in	IN
cord-267897-w4pbq2lb	13	23	terms	term	NNS
cord-267897-w4pbq2lb	13	24	of	of	IN
cord-267897-w4pbq2lb	13	25	surface	surface	NN
cord-267897-w4pbq2lb	13	26	marker	marker	NN
cord-267897-w4pbq2lb	13	27	expression	expression	NN
cord-267897-w4pbq2lb	13	28	profiles	profile	NNS
cord-267897-w4pbq2lb	13	29	,	,	,
cord-267897-w4pbq2lb	13	30	isotypic	isotypic	JJ
cord-267897-w4pbq2lb	13	31	profiles	profile	NNS
cord-267897-w4pbq2lb	13	32	,	,	,
cord-267897-w4pbq2lb	13	33	and	and	CC
cord-267897-w4pbq2lb	13	34	cytokine	cytokine	NN
cord-267897-w4pbq2lb	13	35	profiles	profile	NNS
cord-267897-w4pbq2lb	13	36	.	.	.
cord-267897-w4pbq2lb	14	1	In	in	IN
cord-267897-w4pbq2lb	14	2	the	the	DT
cord-267897-w4pbq2lb	14	3	past	past	NN
cord-267897-w4pbq2lb	14	4	10years	10year	NNS
cord-267897-w4pbq2lb	14	5	,	,	,
cord-267897-w4pbq2lb	14	6	the	the	DT
cord-267897-w4pbq2lb	14	7	discovery	discovery	NN
cord-267897-w4pbq2lb	14	8	of	of	IN
cord-267897-w4pbq2lb	14	9	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	14	10	-	-	HYPH
cord-267897-w4pbq2lb	14	11	mediated	mediate	VBN
cord-267897-w4pbq2lb	14	12	induction	induction	NN
cord-267897-w4pbq2lb	14	13	of	of	IN
cord-267897-w4pbq2lb	14	14	the	the	DT
cord-267897-w4pbq2lb	14	15	NALP3	NALP3	NNP
cord-267897-w4pbq2lb	14	16	inflammasome	inflammasome	NNP
cord-267897-w4pbq2lb	14	17	and	and	CC
cord-267897-w4pbq2lb	14	18	its	-PRON-	PRP$
cord-267897-w4pbq2lb	14	19	impact	impact	NN
cord-267897-w4pbq2lb	14	20	on	on	IN
cord-267897-w4pbq2lb	14	21	the	the	DT
cord-267897-w4pbq2lb	14	22	secretion	secretion	NN
cord-267897-w4pbq2lb	14	23	of	of	IN
cord-267897-w4pbq2lb	14	24	interleukin	interleukin	NN
cord-267897-w4pbq2lb	14	25	(	(	-LRB-
cord-267897-w4pbq2lb	14	26	IL)-1β	IL)-1β	NNP
cord-267897-w4pbq2lb	14	27	and	and	CC
cord-267897-w4pbq2lb	14	28	IL-18	IL-18	NNP
cord-267897-w4pbq2lb	14	29	as	as	IN
cord-267897-w4pbq2lb	14	30	proinflammatory	proinflammatory	JJ
cord-267897-w4pbq2lb	14	31	mediators	mediator	NNS
cord-267897-w4pbq2lb	14	32	in	in	IN
cord-267897-w4pbq2lb	14	33	the	the	DT
cord-267897-w4pbq2lb	14	34	early	early	JJ
cord-267897-w4pbq2lb	14	35	phases	phase	NNS
cord-267897-w4pbq2lb	14	36	of	of	IN
cord-267897-w4pbq2lb	14	37	immune	immune	JJ
cord-267897-w4pbq2lb	14	38	response	response	NN
cord-267897-w4pbq2lb	14	39	has	have	VBZ
cord-267897-w4pbq2lb	14	40	been	be	VBN
cord-267897-w4pbq2lb	14	41	described	describe	VBN
cord-267897-w4pbq2lb	14	42	as	as	IN
cord-267897-w4pbq2lb	14	43	an	an	DT
cord-267897-w4pbq2lb	14	44	important	important	JJ
cord-267897-w4pbq2lb	14	45	mechanism	mechanism	NN
cord-267897-w4pbq2lb	14	46	for	for	IN
cord-267897-w4pbq2lb	14	47	the	the	DT
cord-267897-w4pbq2lb	14	48	function	function	NN
cord-267897-w4pbq2lb	14	49	of	of	IN
cord-267897-w4pbq2lb	14	50	these	these	DT
cord-267897-w4pbq2lb	14	51	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	14	52	.	.	.
cord-267897-w4pbq2lb	15	1	Two	two	CD
cord-267897-w4pbq2lb	15	2	categories	category	NNS
cord-267897-w4pbq2lb	15	3	of	of	IN
cord-267897-w4pbq2lb	15	4	inorganic	inorganic	JJ
cord-267897-w4pbq2lb	15	5	mineral	mineral	NN
cord-267897-w4pbq2lb	15	6	compounds	compound	NNS
cord-267897-w4pbq2lb	15	7	have	have	VBP
cord-267897-w4pbq2lb	15	8	been	be	VBN
cord-267897-w4pbq2lb	15	9	applied	apply	VBN
cord-267897-w4pbq2lb	15	10	as	as	IN
cord-267897-w4pbq2lb	15	11	immunological	immunological	JJ
cord-267897-w4pbq2lb	15	12	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	15	13	in	in	IN
cord-267897-w4pbq2lb	15	14	vaccine	vaccine	NN
cord-267897-w4pbq2lb	15	15	formulation	formulation	NN
cord-267897-w4pbq2lb	15	16	,	,	,
cord-267897-w4pbq2lb	15	17	aluminum	aluminum	NN
cord-267897-w4pbq2lb	15	18	compounds	compound	NNS
cord-267897-w4pbq2lb	15	19	and	and	CC
cord-267897-w4pbq2lb	15	20	calcium	calcium	NN
cord-267897-w4pbq2lb	15	21	phosphate	phosphate	NN
cord-267897-w4pbq2lb	15	22	.	.	.
cord-267897-w4pbq2lb	16	1	Of	of	IN
cord-267897-w4pbq2lb	16	2	these	these	DT
cord-267897-w4pbq2lb	16	3	two	two	CD
cord-267897-w4pbq2lb	16	4	,	,	,
cord-267897-w4pbq2lb	16	5	the	the	DT
cord-267897-w4pbq2lb	16	6	aluminum	aluminum	NN
cord-267897-w4pbq2lb	16	7	compounds	compound	NNS
cord-267897-w4pbq2lb	16	8	have	have	VBP
cord-267897-w4pbq2lb	16	9	the	the	DT
cord-267897-w4pbq2lb	16	10	longest	long	JJS
cord-267897-w4pbq2lb	16	11	history	history	NN
cord-267897-w4pbq2lb	16	12	and	and	CC
cord-267897-w4pbq2lb	16	13	by	by	IN
cord-267897-w4pbq2lb	16	14	far	far	RB
cord-267897-w4pbq2lb	16	15	the	the	DT
cord-267897-w4pbq2lb	16	16	most	most	RBS
cord-267897-w4pbq2lb	16	17	comprehensive	comprehensive	JJ
cord-267897-w4pbq2lb	16	18	record	record	NN
cord-267897-w4pbq2lb	16	19	of	of	IN
cord-267897-w4pbq2lb	16	20	use	use	NN
cord-267897-w4pbq2lb	16	21	.	.	.
cord-267897-w4pbq2lb	17	1	Both	both	DT
cord-267897-w4pbq2lb	17	2	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	17	3	are	be	VBP
cord-267897-w4pbq2lb	17	4	generally	generally	RB
cord-267897-w4pbq2lb	17	5	regarded	regard	VBN
cord-267897-w4pbq2lb	17	6	as	as	RB
cord-267897-w4pbq2lb	17	7	safe	safe	JJ
cord-267897-w4pbq2lb	17	8	to	to	TO
cord-267897-w4pbq2lb	17	9	use	use	VB
cord-267897-w4pbq2lb	17	10	in	in	IN
cord-267897-w4pbq2lb	17	11	human	human	JJ
cord-267897-w4pbq2lb	17	12	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	17	13	when	when	WRB
cord-267897-w4pbq2lb	17	14	used	use	VBN
cord-267897-w4pbq2lb	17	15	in	in	IN
cord-267897-w4pbq2lb	17	16	accordance	accordance	NN
cord-267897-w4pbq2lb	17	17	with	with	IN
cord-267897-w4pbq2lb	17	18	the	the	DT
cord-267897-w4pbq2lb	17	19	current	current	JJ
cord-267897-w4pbq2lb	17	20	vaccination	vaccination	NN
cord-267897-w4pbq2lb	17	21	schedules	schedule	NNS
cord-267897-w4pbq2lb	17	22	.	.	.
cord-267897-w4pbq2lb	18	1	1	1	CD
cord-267897-w4pbq2lb	18	2	,	,	,
cord-267897-w4pbq2lb	18	3	2	2	CD
cord-267897-w4pbq2lb	18	4	A.T.	A.T.	NNP
cord-267897-w4pbq2lb	18	5	Glenny	Glenny	NNP
cord-267897-w4pbq2lb	18	6	and	and	CC
cord-267897-w4pbq2lb	18	7	coworkers	coworker	NNS
cord-267897-w4pbq2lb	18	8	were	be	VBD
cord-267897-w4pbq2lb	18	9	the	the	DT
cord-267897-w4pbq2lb	18	10	first	first	JJ
cord-267897-w4pbq2lb	18	11	to	to	TO
cord-267897-w4pbq2lb	18	12	demonstrate	demonstrate	VB
cord-267897-w4pbq2lb	18	13	the	the	DT
cord-267897-w4pbq2lb	18	14	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	18	15	effect	effect	NN
cord-267897-w4pbq2lb	18	16	of	of	IN
cord-267897-w4pbq2lb	18	17	aluminum	aluminum	NN
cord-267897-w4pbq2lb	18	18	compounds	compound	NNS
cord-267897-w4pbq2lb	18	19	in	in	IN
cord-267897-w4pbq2lb	18	20	1926	1926	CD
cord-267897-w4pbq2lb	18	21	.	.	.
cord-267897-w4pbq2lb	19	1	Glenny	Glenny	NNP
cord-267897-w4pbq2lb	19	2	prepared	prepare	VBD
cord-267897-w4pbq2lb	19	3	a	a	DT
cord-267897-w4pbq2lb	19	4	variety	variety	NN
cord-267897-w4pbq2lb	19	5	of	of	IN
cord-267897-w4pbq2lb	19	6	diphtheria	diphtheria	NN
cord-267897-w4pbq2lb	19	7	toxoid	toxoid	NN
cord-267897-w4pbq2lb	19	8	precipitates	precipitate	VBZ
cord-267897-w4pbq2lb	19	9	and	and	CC
cord-267897-w4pbq2lb	19	10	investigated	investigate	VBD
cord-267897-w4pbq2lb	19	11	their	-PRON-	PRP$
cord-267897-w4pbq2lb	19	12	immunogenicity	immunogenicity	NN
cord-267897-w4pbq2lb	19	13	.	.	.
cord-267897-w4pbq2lb	20	1	Among	among	IN
cord-267897-w4pbq2lb	20	2	these	these	DT
cord-267897-w4pbq2lb	20	3	were	be	VBD
cord-267897-w4pbq2lb	20	4	toxoids	toxoid	NNS
cord-267897-w4pbq2lb	20	5	precipitated	precipitate	VBN
cord-267897-w4pbq2lb	20	6	by	by	IN
cord-267897-w4pbq2lb	20	7	the	the	DT
cord-267897-w4pbq2lb	20	8	addition	addition	NN
cord-267897-w4pbq2lb	20	9	of	of	IN
cord-267897-w4pbq2lb	20	10	potassium	potassium	NN
cord-267897-w4pbq2lb	20	11	alum	alum	NN
cord-267897-w4pbq2lb	20	12	[	[	-LRB-
cord-267897-w4pbq2lb	20	13	KAl(SO	KAl(SO	NNP
cord-267897-w4pbq2lb	20	14	4	4	CD
cord-267897-w4pbq2lb	20	15	)	)	-RRB-
cord-267897-w4pbq2lb	20	16	2	2	CD
cord-267897-w4pbq2lb	20	17	:	:	:
cord-267897-w4pbq2lb	20	18	12H	12h	CD
cord-267897-w4pbq2lb	20	19	2	2	CD
cord-267897-w4pbq2lb	20	20	O	o	NN
cord-267897-w4pbq2lb	20	21	]	]	-RRB-
cord-267897-w4pbq2lb	20	22	.	.	.
cord-267897-w4pbq2lb	21	1	Glenny	Glenny	NNP
cord-267897-w4pbq2lb	21	2	observed	observe	VBD
cord-267897-w4pbq2lb	21	3	that	that	IN
cord-267897-w4pbq2lb	21	4	injecting	inject	VBG
cord-267897-w4pbq2lb	21	5	the	the	DT
cord-267897-w4pbq2lb	21	6	diphtheria	diphtheria	NN
cord-267897-w4pbq2lb	21	7	toxoid	toxoid	NN
cord-267897-w4pbq2lb	21	8	as	as	IN
cord-267897-w4pbq2lb	21	9	an	an	DT
cord-267897-w4pbq2lb	21	10	alum	alum	NN
cord-267897-w4pbq2lb	21	11	precipitate	precipitate	NN
cord-267897-w4pbq2lb	21	12	led	lead	VBD
cord-267897-w4pbq2lb	21	13	to	to	IN
cord-267897-w4pbq2lb	21	14	a	a	DT
cord-267897-w4pbq2lb	21	15	significant	significant	JJ
cord-267897-w4pbq2lb	21	16	increase	increase	NN
cord-267897-w4pbq2lb	21	17	in	in	IN
cord-267897-w4pbq2lb	21	18	the	the	DT
cord-267897-w4pbq2lb	21	19	immune	immune	JJ
cord-267897-w4pbq2lb	21	20	response	response	NN
cord-267897-w4pbq2lb	21	21	against	against	IN
cord-267897-w4pbq2lb	21	22	the	the	DT
cord-267897-w4pbq2lb	21	23	toxoid	toxoid	NN
cord-267897-w4pbq2lb	21	24	.	.	.
cord-267897-w4pbq2lb	22	1	3	3	LS
cord-267897-w4pbq2lb	22	2	,	,	,
cord-267897-w4pbq2lb	22	3	4	4	CD
cord-267897-w4pbq2lb	22	4	Vaccines	vaccine	NNS
cord-267897-w4pbq2lb	22	5	prepared	prepare	VBN
cord-267897-w4pbq2lb	22	6	in	in	IN
cord-267897-w4pbq2lb	22	7	accordance	accordance	NN
cord-267897-w4pbq2lb	22	8	with	with	IN
cord-267897-w4pbq2lb	22	9	this	this	DT
cord-267897-w4pbq2lb	22	10	principle	principle	NN
cord-267897-w4pbq2lb	22	11	have	have	VBP
cord-267897-w4pbq2lb	22	12	been	be	VBN
cord-267897-w4pbq2lb	22	13	used	use	VBN
cord-267897-w4pbq2lb	22	14	in	in	IN
cord-267897-w4pbq2lb	22	15	practical	practical	JJ
cord-267897-w4pbq2lb	22	16	vaccination	vaccination	NN
cord-267897-w4pbq2lb	22	17	and	and	CC
cord-267897-w4pbq2lb	22	18	are	be	VBP
cord-267897-w4pbq2lb	22	19	referred	refer	VBN
cord-267897-w4pbq2lb	22	20	to	to	IN
cord-267897-w4pbq2lb	22	21	as	as	IN
cord-267897-w4pbq2lb	22	22	alum	alum	NN
cord-267897-w4pbq2lb	22	23	-	-	HYPH
cord-267897-w4pbq2lb	22	24	precipitated	precipitate	VBN
cord-267897-w4pbq2lb	22	25	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	22	26	.	.	.
cord-267897-w4pbq2lb	23	1	This	this	DT
cord-267897-w4pbq2lb	23	2	approach	approach	NN
cord-267897-w4pbq2lb	23	3	,	,	,
cord-267897-w4pbq2lb	23	4	however	however	RB
cord-267897-w4pbq2lb	23	5	,	,	,
cord-267897-w4pbq2lb	23	6	has	have	VBZ
cord-267897-w4pbq2lb	23	7	a	a	DT
cord-267897-w4pbq2lb	23	8	number	number	NN
cord-267897-w4pbq2lb	23	9	of	of	IN
cord-267897-w4pbq2lb	23	10	drawbacks	drawback	NNS
cord-267897-w4pbq2lb	23	11	.	.	.
cord-267897-w4pbq2lb	24	1	It	-PRON-	PRP
cord-267897-w4pbq2lb	24	2	was	be	VBD
cord-267897-w4pbq2lb	24	3	found	find	VBN
cord-267897-w4pbq2lb	24	4	5	5	CD
cord-267897-w4pbq2lb	24	5	that	that	IN
cord-267897-w4pbq2lb	24	6	such	such	JJ
cord-267897-w4pbq2lb	24	7	preparations	preparation	NNS
cord-267897-w4pbq2lb	24	8	could	could	MD
cord-267897-w4pbq2lb	24	9	be	be	VB
cord-267897-w4pbq2lb	24	10	highly	highly	RB
cord-267897-w4pbq2lb	24	11	heterogeneous	heterogeneous	JJ
cord-267897-w4pbq2lb	24	12	,	,	,
cord-267897-w4pbq2lb	24	13	depending	depend	VBG
cord-267897-w4pbq2lb	24	14	on	on	IN
cord-267897-w4pbq2lb	25	1	which	which	WDT
cord-267897-w4pbq2lb	25	2	anions	anion	NNS
cord-267897-w4pbq2lb	25	3	,	,	,
cord-267897-w4pbq2lb	25	4	such	such	JJ
cord-267897-w4pbq2lb	25	5	as	as	IN
cord-267897-w4pbq2lb	25	6	bicarbonate	bicarbonate	NN
cord-267897-w4pbq2lb	25	7	,	,	,
cord-267897-w4pbq2lb	25	8	sulfate	sulfate	NN
cord-267897-w4pbq2lb	25	9	,	,	,
cord-267897-w4pbq2lb	25	10	or	or	CC
cord-267897-w4pbq2lb	25	11	phosphate	phosphate	NN
cord-267897-w4pbq2lb	25	12	,	,	,
cord-267897-w4pbq2lb	25	13	were	be	VBD
cord-267897-w4pbq2lb	25	14	present	present	JJ
cord-267897-w4pbq2lb	25	15	at	at	IN
cord-267897-w4pbq2lb	25	16	the	the	DT
cord-267897-w4pbq2lb	25	17	time	time	NN
cord-267897-w4pbq2lb	25	18	of	of	IN
cord-267897-w4pbq2lb	25	19	precipitation	precipitation	NN
cord-267897-w4pbq2lb	25	20	,	,	,
cord-267897-w4pbq2lb	25	21	e.g.	e.g.	RB
cord-267897-w4pbq2lb	25	22	,	,	,
cord-267897-w4pbq2lb	25	23	as	as	IN
cord-267897-w4pbq2lb	25	24	buffer	buffer	NN
cord-267897-w4pbq2lb	25	25	constituents	constituent	NNS
cord-267897-w4pbq2lb	25	26	or	or	CC
cord-267897-w4pbq2lb	25	27	growth	growth	NN
cord-267897-w4pbq2lb	25	28	media	medium	NNS
cord-267897-w4pbq2lb	25	29	residues	residue	NNS
cord-267897-w4pbq2lb	25	30	in	in	IN
cord-267897-w4pbq2lb	25	31	the	the	DT
cord-267897-w4pbq2lb	25	32	antigen	antigen	NN
cord-267897-w4pbq2lb	25	33	solution	solution	NN
cord-267897-w4pbq2lb	25	34	.	.	.
cord-267897-w4pbq2lb	26	1	In	in	IN
cord-267897-w4pbq2lb	26	2	addition	addition	NN
cord-267897-w4pbq2lb	26	3	to	to	IN
cord-267897-w4pbq2lb	26	4	this	this	DT
cord-267897-w4pbq2lb	26	5	,	,	,
cord-267897-w4pbq2lb	26	6	Al	Al	NNP
cord-267897-w4pbq2lb	26	7	precipitation	precipitation	NN
cord-267897-w4pbq2lb	26	8	with	with	IN
cord-267897-w4pbq2lb	26	9	the	the	DT
cord-267897-w4pbq2lb	26	10	antigen	antigen	NN
cord-267897-w4pbq2lb	26	11	takes	take	VBZ
cord-267897-w4pbq2lb	26	12	place	place	NN
cord-267897-w4pbq2lb	26	13	under	under	IN
cord-267897-w4pbq2lb	26	14	alkaline	alkaline	JJ
cord-267897-w4pbq2lb	26	15	conditions	condition	NNS
cord-267897-w4pbq2lb	26	16	,	,	,
cord-267897-w4pbq2lb	26	17	and	and	CC
cord-267897-w4pbq2lb	26	18	this	this	DT
cord-267897-w4pbq2lb	26	19	may	may	MD
cord-267897-w4pbq2lb	26	20	in	in	IN
cord-267897-w4pbq2lb	26	21	some	some	DT
cord-267897-w4pbq2lb	26	22	cases	case	NNS
cord-267897-w4pbq2lb	26	23	introduce	introduce	VBP
cord-267897-w4pbq2lb	26	24	alterations	alteration	NNS
cord-267897-w4pbq2lb	26	25	to	to	IN
cord-267897-w4pbq2lb	26	26	the	the	DT
cord-267897-w4pbq2lb	26	27	antigen	antigen	NN
cord-267897-w4pbq2lb	26	28	.	.	.
cord-267897-w4pbq2lb	27	1	In	in	IN
cord-267897-w4pbq2lb	27	2	contrast	contrast	NN
cord-267897-w4pbq2lb	27	3	,	,	,
cord-267897-w4pbq2lb	27	4	preformed	preformed	JJ
cord-267897-w4pbq2lb	27	5	aluminum	aluminum	NN
cord-267897-w4pbq2lb	27	6	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	27	7	,	,	,
cord-267897-w4pbq2lb	27	8	in	in	IN
cord-267897-w4pbq2lb	27	9	the	the	DT
cord-267897-w4pbq2lb	27	10	form	form	NN
cord-267897-w4pbq2lb	27	11	of	of	IN
cord-267897-w4pbq2lb	27	12	hydrated	hydrated	JJ
cord-267897-w4pbq2lb	27	13	colloid	colloid	NN
cord-267897-w4pbq2lb	27	14	"	"	''
cord-267897-w4pbq2lb	27	15	gels	gel	NNS
cord-267897-w4pbq2lb	27	16	,	,	,
cord-267897-w4pbq2lb	27	17	"	"	''
cord-267897-w4pbq2lb	27	18	has	have	VBZ
cord-267897-w4pbq2lb	27	19	the	the	DT
cord-267897-w4pbq2lb	27	20	ability	ability	NN
cord-267897-w4pbq2lb	27	21	to	to	TO
cord-267897-w4pbq2lb	27	22	adsorb	adsorb	VB
cord-267897-w4pbq2lb	27	23	protein	protein	NN
cord-267897-w4pbq2lb	27	24	antigens	antigen	NNS
cord-267897-w4pbq2lb	27	25	from	from	IN
cord-267897-w4pbq2lb	27	26	an	an	DT
cord-267897-w4pbq2lb	27	27	aqueous	aqueous	JJ
cord-267897-w4pbq2lb	27	28	solution	solution	NN
cord-267897-w4pbq2lb	27	29	and	and	CC
cord-267897-w4pbq2lb	27	30	such	such	JJ
cord-267897-w4pbq2lb	27	31	gels	gel	NNS
cord-267897-w4pbq2lb	27	32	can	can	MD
cord-267897-w4pbq2lb	27	33	be	be	VB
cord-267897-w4pbq2lb	27	34	preformed	preform	VBN
cord-267897-w4pbq2lb	27	35	in	in	IN
cord-267897-w4pbq2lb	27	36	a	a	DT
cord-267897-w4pbq2lb	27	37	well	well	RB
cord-267897-w4pbq2lb	27	38	-	-	HYPH
cord-267897-w4pbq2lb	27	39	defined	define	VBN
cord-267897-w4pbq2lb	27	40	and	and	CC
cord-267897-w4pbq2lb	27	41	standardized	standardized	JJ
cord-267897-w4pbq2lb	27	42	way	way	NN
cord-267897-w4pbq2lb	27	43	.	.	.
cord-267897-w4pbq2lb	28	1	6	6	CD
cord-267897-w4pbq2lb	29	1	Vaccine	vaccine	NN
cord-267897-w4pbq2lb	29	2	preparations	preparation	NNS
cord-267897-w4pbq2lb	29	3	based	base	VBN
cord-267897-w4pbq2lb	29	4	on	on	IN
cord-267897-w4pbq2lb	29	5	adsorption	adsorption	NN
cord-267897-w4pbq2lb	29	6	of	of	IN
cord-267897-w4pbq2lb	29	7	the	the	DT
cord-267897-w4pbq2lb	29	8	antigen	antigen	NN
cord-267897-w4pbq2lb	29	9	onto	onto	IN
cord-267897-w4pbq2lb	29	10	a	a	DT
cord-267897-w4pbq2lb	29	11	preformed	preformed	JJ
cord-267897-w4pbq2lb	29	12	aluminum	aluminum	NN
cord-267897-w4pbq2lb	29	13	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	29	14	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	29	15	are	be	VBP
cord-267897-w4pbq2lb	29	16	referred	refer	VBN
cord-267897-w4pbq2lb	29	17	to	to	IN
cord-267897-w4pbq2lb	29	18	as	as	RB
cord-267897-w4pbq2lb	29	19	aluminum	aluminum	NN
cord-267897-w4pbq2lb	29	20	-	-	HYPH
cord-267897-w4pbq2lb	29	21	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	29	22	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	29	23	,	,	,
cord-267897-w4pbq2lb	29	24	in	in	IN
cord-267897-w4pbq2lb	29	25	contrast	contrast	NN
cord-267897-w4pbq2lb	29	26	to	to	IN
cord-267897-w4pbq2lb	29	27	the	the	DT
cord-267897-w4pbq2lb	29	28	alum	alum	NN
cord-267897-w4pbq2lb	29	29	-	-	HYPH
cord-267897-w4pbq2lb	29	30	precipitated	precipitate	VBN
cord-267897-w4pbq2lb	29	31	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	29	32	mentioned	mention	VBN
cord-267897-w4pbq2lb	29	33	earlier	early	RBR
cord-267897-w4pbq2lb	29	34	.	.	.
cord-267897-w4pbq2lb	30	1	Data	datum	NNS
cord-267897-w4pbq2lb	30	2	on	on	IN
cord-267897-w4pbq2lb	30	3	the	the	DT
cord-267897-w4pbq2lb	30	4	use	use	NN
cord-267897-w4pbq2lb	30	5	of	of	IN
cord-267897-w4pbq2lb	30	6	alum	alum	NN
cord-267897-w4pbq2lb	30	7	-	-	HYPH
cord-267897-w4pbq2lb	30	8	precipitated	precipitate	VBN
cord-267897-w4pbq2lb	30	9	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	30	10	can	can	MD
cord-267897-w4pbq2lb	30	11	be	be	VB
cord-267897-w4pbq2lb	30	12	found	find	VBN
cord-267897-w4pbq2lb	30	13	in	in	IN
cord-267897-w4pbq2lb	30	14	the	the	DT
cord-267897-w4pbq2lb	30	15	older	old	JJR
cord-267897-w4pbq2lb	30	16	literature	literature	NN
cord-267897-w4pbq2lb	30	17	,	,	,
cord-267897-w4pbq2lb	30	18	7	7	CD
cord-267897-w4pbq2lb	30	19	but	but	CC
cord-267897-w4pbq2lb	30	20	in	in	IN
cord-267897-w4pbq2lb	30	21	practical	practical	JJ
cord-267897-w4pbq2lb	30	22	vaccination	vaccination	NN
cord-267897-w4pbq2lb	30	23	,	,	,
cord-267897-w4pbq2lb	30	24	the	the	DT
cord-267897-w4pbq2lb	30	25	adsorption	adsorption	NN
cord-267897-w4pbq2lb	30	26	onto	onto	IN
cord-267897-w4pbq2lb	30	27	preformed	preformed	JJ
cord-267897-w4pbq2lb	30	28	aluminum	aluminum	NN
cord-267897-w4pbq2lb	30	29	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	30	30	and	and	CC
cord-267897-w4pbq2lb	30	31	aluminum	aluminum	NN
cord-267897-w4pbq2lb	30	32	phosphate	phosphate	NN
cord-267897-w4pbq2lb	30	33	gels	gel	NNS
cord-267897-w4pbq2lb	30	34	has	have	VBZ
cord-267897-w4pbq2lb	30	35	now	now	RB
cord-267897-w4pbq2lb	30	36	almost	almost	RB
cord-267897-w4pbq2lb	30	37	completely	completely	RB
cord-267897-w4pbq2lb	30	38	substituted	substitute	VBD
cord-267897-w4pbq2lb	30	39	the	the	DT
cord-267897-w4pbq2lb	30	40	alum	alum	NN
cord-267897-w4pbq2lb	30	41	precipitation	precipitation	NN
cord-267897-w4pbq2lb	30	42	in	in	IN
cord-267897-w4pbq2lb	30	43	vaccine	vaccine	NN
cord-267897-w4pbq2lb	30	44	formulation	formulation	NN
cord-267897-w4pbq2lb	30	45	.	.	.
cord-267897-w4pbq2lb	31	1	Aluminum	aluminum	NN
cord-267897-w4pbq2lb	31	2	phosphate	phosphate	NN
cord-267897-w4pbq2lb	31	3	was	be	VBD
cord-267897-w4pbq2lb	31	4	introduced	introduce	VBN
cord-267897-w4pbq2lb	31	5	as	as	IN
cord-267897-w4pbq2lb	31	6	an	an	DT
cord-267897-w4pbq2lb	31	7	alternative	alternative	JJ
cord-267897-w4pbq2lb	31	8	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	31	9	two	two	CD
cord-267897-w4pbq2lb	31	10	decades	decade	NNS
cord-267897-w4pbq2lb	31	11	after	after	IN
cord-267897-w4pbq2lb	31	12	Glenny	Glenny	NNP
cord-267897-w4pbq2lb	31	13	's	's	POS
cord-267897-w4pbq2lb	31	14	work	work	NN
cord-267897-w4pbq2lb	31	15	.	.	.
cord-267897-w4pbq2lb	32	1	In	in	IN
cord-267897-w4pbq2lb	32	2	1946	1946	CD
cord-267897-w4pbq2lb	32	3	,	,	,
cord-267897-w4pbq2lb	32	4	Hans	Hans	NNP
cord-267897-w4pbq2lb	32	5	Ericsson	Ericsson	NNP
cord-267897-w4pbq2lb	32	6	from	from	IN
cord-267897-w4pbq2lb	32	7	Sweden	Sweden	NNP
cord-267897-w4pbq2lb	32	8	8	8	CD
cord-267897-w4pbq2lb	32	9	devised	devise	VBD
cord-267897-w4pbq2lb	32	10	a	a	DT
cord-267897-w4pbq2lb	32	11	method	method	NN
cord-267897-w4pbq2lb	32	12	in	in	IN
cord-267897-w4pbq2lb	32	13	which	which	WDT
cord-267897-w4pbq2lb	32	14	diphtheria	diphtheria	NN
cord-267897-w4pbq2lb	32	15	toxoid	toxoid	NN
cord-267897-w4pbq2lb	32	16	was	be	VBD
cord-267897-w4pbq2lb	32	17	coprecipitated	coprecipitate	VBN
cord-267897-w4pbq2lb	32	18	into	into	IN
cord-267897-w4pbq2lb	32	19	a	a	DT
cord-267897-w4pbq2lb	32	20	matrix	matrix	NN
cord-267897-w4pbq2lb	32	21	of	of	IN
cord-267897-w4pbq2lb	32	22	aluminum	aluminum	NN
cord-267897-w4pbq2lb	32	23	phosphate	phosphate	NN
cord-267897-w4pbq2lb	32	24	,	,	,
cord-267897-w4pbq2lb	32	25	corresponding	correspond	VBG
cord-267897-w4pbq2lb	32	26	to	to	IN
cord-267897-w4pbq2lb	32	27	the	the	DT
cord-267897-w4pbq2lb	32	28	alum	alum	NN
cord-267897-w4pbq2lb	32	29	precipitation	precipitation	NN
cord-267897-w4pbq2lb	32	30	method	method	NN
cord-267897-w4pbq2lb	32	31	described	describe	VBN
cord-267897-w4pbq2lb	32	32	earlier	early	RBR
cord-267897-w4pbq2lb	32	33	.	.	.
cord-267897-w4pbq2lb	33	1	Lewis	Lewis	NNP
cord-267897-w4pbq2lb	33	2	B.	B.	NNP
cord-267897-w4pbq2lb	33	3	Holt	Holt	NNP
cord-267897-w4pbq2lb	33	4	9	9	CD
cord-267897-w4pbq2lb	33	5	demonstrated	demonstrate	VBD
cord-267897-w4pbq2lb	33	6	the	the	DT
cord-267897-w4pbq2lb	33	7	following	following	JJ
cord-267897-w4pbq2lb	33	8	year	year	NN
cord-267897-w4pbq2lb	33	9	that	that	WDT
cord-267897-w4pbq2lb	33	10	preformed	preform	VBD
cord-267897-w4pbq2lb	33	11	aluminum	aluminum	NN
cord-267897-w4pbq2lb	33	12	phosphate	phosphate	NN
cord-267897-w4pbq2lb	33	13	(	(	-LRB-
cord-267897-w4pbq2lb	33	14	prepared	prepare	VBN
cord-267897-w4pbq2lb	33	15	from	from	IN
cord-267897-w4pbq2lb	33	16	aluminum	aluminum	NN
cord-267897-w4pbq2lb	33	17	chloride	chloride	NN
cord-267897-w4pbq2lb	33	18	and	and	CC
cord-267897-w4pbq2lb	33	19	trisodium	trisodium	NN
cord-267897-w4pbq2lb	33	20	phosphate	phosphate	NN
cord-267897-w4pbq2lb	33	21	)	)	-RRB-
cord-267897-w4pbq2lb	33	22	acted	act	VBD
cord-267897-w4pbq2lb	33	23	as	as	IN
cord-267897-w4pbq2lb	33	24	an	an	DT
cord-267897-w4pbq2lb	33	25	adsorbant	adsorbant	JJ
cord-267897-w4pbq2lb	33	26	and	and	CC
cord-267897-w4pbq2lb	33	27	was	be	VBD
cord-267897-w4pbq2lb	33	28	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	33	29	-	-	HYPH
cord-267897-w4pbq2lb	33	30	active	active	JJ
cord-267897-w4pbq2lb	33	31	with	with	IN
cord-267897-w4pbq2lb	33	32	diphtheria	diphtheria	NN
cord-267897-w4pbq2lb	33	33	toxoid	toxoid	NN
cord-267897-w4pbq2lb	33	34	.	.	.
cord-267897-w4pbq2lb	34	1	Aluminum	aluminum	NN
cord-267897-w4pbq2lb	34	2	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	34	3	has	have	VBZ
cord-267897-w4pbq2lb	34	4	been	be	VBN
cord-267897-w4pbq2lb	34	5	included	include	VBN
cord-267897-w4pbq2lb	34	6	into	into	IN
cord-267897-w4pbq2lb	34	7	composite	composite	JJ
cord-267897-w4pbq2lb	34	8	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	34	9	formulations	formulation	NNS
cord-267897-w4pbq2lb	34	10	,	,	,
cord-267897-w4pbq2lb	34	11	such	such	JJ
cord-267897-w4pbq2lb	34	12	as	as	IN
cord-267897-w4pbq2lb	34	13	the	the	DT
cord-267897-w4pbq2lb	34	14	AS04	AS04	NNP
cord-267897-w4pbq2lb	34	15	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	34	16	formulation	formulation	NN
cord-267897-w4pbq2lb	34	17	proprietary	proprietary	JJ
cord-267897-w4pbq2lb	34	18	to	to	IN
cord-267897-w4pbq2lb	34	19	Glaxo	Glaxo	NNP
cord-267897-w4pbq2lb	34	20	SmithKline	SmithKline	NNP
cord-267897-w4pbq2lb	34	21	,	,	,
cord-267897-w4pbq2lb	34	22	which	which	WDT
cord-267897-w4pbq2lb	34	23	consists	consist	VBZ
cord-267897-w4pbq2lb	34	24	of	of	IN
cord-267897-w4pbq2lb	34	25	aluminum	aluminum	NN
cord-267897-w4pbq2lb	34	26	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	34	27	in	in	IN
cord-267897-w4pbq2lb	34	28	combination	combination	NN
cord-267897-w4pbq2lb	34	29	with	with	IN
cord-267897-w4pbq2lb	34	30	monophosphoryl	monophosphoryl	NNP
cord-267897-w4pbq2lb	34	31	lipid	lipid	VBG
cord-267897-w4pbq2lb	34	32	A	A	NNP
cord-267897-w4pbq2lb	34	33	(	(	-LRB-
cord-267897-w4pbq2lb	34	34	MPL	MPL	NNP
cord-267897-w4pbq2lb	34	35	)	)	-RRB-
cord-267897-w4pbq2lb	34	36	.	.	.
cord-267897-w4pbq2lb	35	1	Occasionally	occasionally	RB
cord-267897-w4pbq2lb	35	2	,	,	,
cord-267897-w4pbq2lb	35	3	the	the	DT
cord-267897-w4pbq2lb	35	4	word	word	NN
cord-267897-w4pbq2lb	35	5	"	"	``
cord-267897-w4pbq2lb	35	6	alum	alum	NN
cord-267897-w4pbq2lb	35	7	"	"	''
cord-267897-w4pbq2lb	35	8	is	be	VBZ
cord-267897-w4pbq2lb	35	9	seen	see	VBN
cord-267897-w4pbq2lb	35	10	in	in	IN
cord-267897-w4pbq2lb	35	11	the	the	DT
cord-267897-w4pbq2lb	35	12	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	35	13	literature	literature	NN
cord-267897-w4pbq2lb	35	14	to	to	TO
cord-267897-w4pbq2lb	35	15	describe	describe	VB
cord-267897-w4pbq2lb	35	16	both	both	DT
cord-267897-w4pbq2lb	35	17	aluminum	aluminum	NN
cord-267897-w4pbq2lb	35	18	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	35	19	and	and	CC
cord-267897-w4pbq2lb	35	20	aluminum	aluminum	NN
cord-267897-w4pbq2lb	35	21	phosphate	phosphate	NN
cord-267897-w4pbq2lb	35	22	gels	gel	NNS
cord-267897-w4pbq2lb	35	23	,	,	,
cord-267897-w4pbq2lb	35	24	but	but	CC
cord-267897-w4pbq2lb	35	25	this	this	DT
cord-267897-w4pbq2lb	35	26	is	be	VBZ
cord-267897-w4pbq2lb	35	27	incorrect	incorrect	JJ
cord-267897-w4pbq2lb	35	28	use	use	NN
cord-267897-w4pbq2lb	35	29	of	of	IN
cord-267897-w4pbq2lb	35	30	terminology	terminology	NN
cord-267897-w4pbq2lb	35	31	.	.	.
cord-267897-w4pbq2lb	36	1	Potassium	potassium	NN
cord-267897-w4pbq2lb	36	2	alum	alum	NN
cord-267897-w4pbq2lb	36	3	,	,	,
cord-267897-w4pbq2lb	36	4	KAl(SO	KAl(SO	NNP
cord-267897-w4pbq2lb	36	5	4	4	CD
cord-267897-w4pbq2lb	36	6	)	)	-RRB-
cord-267897-w4pbq2lb	36	7	2	2	CD
cord-267897-w4pbq2lb	36	8	:	:	:
cord-267897-w4pbq2lb	37	1	12H	12h	LS
cord-267897-w4pbq2lb	37	2	2	2	CD
cord-267897-w4pbq2lb	37	3	O	o	NN
cord-267897-w4pbq2lb	37	4	,	,	,
cord-267897-w4pbq2lb	37	5	is	be	VBZ
cord-267897-w4pbq2lb	37	6	in	in	IN
cord-267897-w4pbq2lb	37	7	accordance	accordance	NN
cord-267897-w4pbq2lb	37	8	with	with	IN
cord-267897-w4pbq2lb	37	9	the	the	DT
cord-267897-w4pbq2lb	37	10	chemical	chemical	NN
cord-267897-w4pbq2lb	37	11	definition	definition	NN
cord-267897-w4pbq2lb	37	12	of	of	IN
cord-267897-w4pbq2lb	37	13	an	an	DT
cord-267897-w4pbq2lb	37	14	alum	alum	NN
cord-267897-w4pbq2lb	37	15	,	,	,
cord-267897-w4pbq2lb	37	16	whereas	whereas	IN
cord-267897-w4pbq2lb	37	17	neither	neither	DT
cord-267897-w4pbq2lb	37	18	aluminum	aluminum	NN
cord-267897-w4pbq2lb	37	19	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	37	20	nor	nor	CC
cord-267897-w4pbq2lb	37	21	aluminum	aluminum	NN
cord-267897-w4pbq2lb	37	22	phosphate	phosphate	NN
cord-267897-w4pbq2lb	37	23	is	be	VBZ
cord-267897-w4pbq2lb	37	24	.	.	.
cord-267897-w4pbq2lb	38	1	Calcium	calcium	NN
cord-267897-w4pbq2lb	38	2	phosphate	phosphate	NN
cord-267897-w4pbq2lb	38	3	was	be	VBD
cord-267897-w4pbq2lb	38	4	developed	develop	VBN
cord-267897-w4pbq2lb	38	5	as	as	IN
cord-267897-w4pbq2lb	38	6	an	an	DT
cord-267897-w4pbq2lb	38	7	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	38	8	by	by	IN
cord-267897-w4pbq2lb	38	9	Edgar	Edgar	NNP
cord-267897-w4pbq2lb	38	10	H.	H.	NNP
cord-267897-w4pbq2lb	38	11	Relyveld	Relyveld	NNP
cord-267897-w4pbq2lb	38	12	in	in	IN
cord-267897-w4pbq2lb	38	13	1958	1958	CD
cord-267897-w4pbq2lb	39	1	(	(	-LRB-
cord-267897-w4pbq2lb	39	2	Relyveld	Relyveld	NNP
cord-267897-w4pbq2lb	39	3	,	,	,
cord-267897-w4pbq2lb	39	4	personal	personal	JJ
cord-267897-w4pbq2lb	39	5	communication	communication	NN
cord-267897-w4pbq2lb	39	6	)	)	-RRB-
cord-267897-w4pbq2lb	39	7	.	.	.
cord-267897-w4pbq2lb	40	1	Also	also	RB
cord-267897-w4pbq2lb	40	2	in	in	IN
cord-267897-w4pbq2lb	40	3	the	the	DT
cord-267897-w4pbq2lb	40	4	case	case	NN
cord-267897-w4pbq2lb	40	5	of	of	IN
cord-267897-w4pbq2lb	40	6	calcium	calcium	NN
cord-267897-w4pbq2lb	40	7	phosphate	phosphate	NN
cord-267897-w4pbq2lb	40	8	the	the	DT
cord-267897-w4pbq2lb	40	9	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	40	10	can	can	MD
cord-267897-w4pbq2lb	40	11	be	be	VB
cord-267897-w4pbq2lb	40	12	coprecipitated	coprecipitate	VBN
cord-267897-w4pbq2lb	40	13	in	in	IN
cord-267897-w4pbq2lb	40	14	the	the	DT
cord-267897-w4pbq2lb	40	15	presence	presence	NN
cord-267897-w4pbq2lb	40	16	of	of	IN
cord-267897-w4pbq2lb	40	17	the	the	DT
cord-267897-w4pbq2lb	40	18	antigen	antigen	NN
cord-267897-w4pbq2lb	40	19	,	,	,
cord-267897-w4pbq2lb	40	20	or	or	CC
cord-267897-w4pbq2lb	40	21	it	-PRON-	PRP
cord-267897-w4pbq2lb	40	22	can	can	MD
cord-267897-w4pbq2lb	40	23	be	be	VB
cord-267897-w4pbq2lb	40	24	preformed	preform	VBN
cord-267897-w4pbq2lb	40	25	in	in	IN
cord-267897-w4pbq2lb	40	26	a	a	DT
cord-267897-w4pbq2lb	40	27	carefully	carefully	RB
cord-267897-w4pbq2lb	40	28	controlled	control	VBN
cord-267897-w4pbq2lb	40	29	chemical	chemical	NN
cord-267897-w4pbq2lb	40	30	environment	environment	NN
cord-267897-w4pbq2lb	40	31	and	and	CC
cord-267897-w4pbq2lb	40	32	subsequently	subsequently	RB
cord-267897-w4pbq2lb	40	33	used	use	VBN
cord-267897-w4pbq2lb	40	34	for	for	IN
cord-267897-w4pbq2lb	40	35	adsorption	adsorption	NN
cord-267897-w4pbq2lb	40	36	of	of	IN
cord-267897-w4pbq2lb	40	37	the	the	DT
cord-267897-w4pbq2lb	40	38	antigen	antigen	NN
cord-267897-w4pbq2lb	40	39	in	in	IN
cord-267897-w4pbq2lb	40	40	question	question	NN
cord-267897-w4pbq2lb	40	41	.	.	.
cord-267897-w4pbq2lb	41	1	Aluminum	aluminum	NN
cord-267897-w4pbq2lb	41	2	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	41	3	and	and	CC
cord-267897-w4pbq2lb	41	4	aluminum	aluminum	NN
cord-267897-w4pbq2lb	41	5	phosphate	phosphate	NN
cord-267897-w4pbq2lb	41	6	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	41	7	are	be	VBP
cord-267897-w4pbq2lb	41	8	generally	generally	RB
cord-267897-w4pbq2lb	41	9	prepared	prepare	VBN
cord-267897-w4pbq2lb	41	10	by	by	IN
cord-267897-w4pbq2lb	41	11	exposing	expose	VBG
cord-267897-w4pbq2lb	41	12	aqueous	aqueous	JJ
cord-267897-w4pbq2lb	41	13	solutions	solution	NNS
cord-267897-w4pbq2lb	41	14	of	of	IN
cord-267897-w4pbq2lb	41	15	aluminum	aluminum	NN
cord-267897-w4pbq2lb	41	16	salts	salt	NNS
cord-267897-w4pbq2lb	41	17	,	,	,
cord-267897-w4pbq2lb	41	18	typically	typically	RB
cord-267897-w4pbq2lb	41	19	as	as	IN
cord-267897-w4pbq2lb	41	20	sulfates	sulfate	NNS
cord-267897-w4pbq2lb	41	21	or	or	CC
cord-267897-w4pbq2lb	41	22	chlorides	chloride	NNS
cord-267897-w4pbq2lb	41	23	,	,	,
cord-267897-w4pbq2lb	41	24	to	to	IN
cord-267897-w4pbq2lb	41	25	alkaline	alkaline	JJ
cord-267897-w4pbq2lb	41	26	conditions	condition	NNS
cord-267897-w4pbq2lb	41	27	in	in	IN
cord-267897-w4pbq2lb	41	28	a	a	DT
cord-267897-w4pbq2lb	41	29	well	well	RB
cord-267897-w4pbq2lb	41	30	-	-	HYPH
cord-267897-w4pbq2lb	41	31	defined	define	VBN
cord-267897-w4pbq2lb	41	32	and	and	CC
cord-267897-w4pbq2lb	41	33	controlled	control	VBN
cord-267897-w4pbq2lb	41	34	chemical	chemical	JJ
cord-267897-w4pbq2lb	41	35	environment	environment	NN
cord-267897-w4pbq2lb	41	36	.	.	.
cord-267897-w4pbq2lb	42	1	Various	various	JJ
cord-267897-w4pbq2lb	42	2	soluble	soluble	JJ
cord-267897-w4pbq2lb	42	3	aluminum	aluminum	NN
cord-267897-w4pbq2lb	42	4	salts	salt	NNS
cord-267897-w4pbq2lb	42	5	can	can	MD
cord-267897-w4pbq2lb	42	6	be	be	VB
cord-267897-w4pbq2lb	42	7	used	use	VBN
cord-267897-w4pbq2lb	42	8	for	for	IN
cord-267897-w4pbq2lb	42	9	the	the	DT
cord-267897-w4pbq2lb	42	10	production	production	NN
cord-267897-w4pbq2lb	42	11	of	of	IN
cord-267897-w4pbq2lb	42	12	aluminum	aluminum	NN
cord-267897-w4pbq2lb	42	13	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	42	14	,	,	,
cord-267897-w4pbq2lb	42	15	but	but	CC
cord-267897-w4pbq2lb	42	16	the	the	DT
cord-267897-w4pbq2lb	42	17	experimental	experimental	JJ
cord-267897-w4pbq2lb	42	18	conditions	condition	NNS
cord-267897-w4pbq2lb	42	19	(	(	-LRB-
cord-267897-w4pbq2lb	42	20	temperature	temperature	NN
cord-267897-w4pbq2lb	42	21	,	,	,
cord-267897-w4pbq2lb	42	22	concentration	concentration	NN
cord-267897-w4pbq2lb	42	23	,	,	,
cord-267897-w4pbq2lb	42	24	and	and	CC
cord-267897-w4pbq2lb	42	25	even	even	RB
cord-267897-w4pbq2lb	42	26	the	the	DT
cord-267897-w4pbq2lb	42	27	rate	rate	NN
cord-267897-w4pbq2lb	42	28	of	of	IN
cord-267897-w4pbq2lb	42	29	addition	addition	NN
cord-267897-w4pbq2lb	42	30	of	of	IN
cord-267897-w4pbq2lb	42	31	reagents	reagent	NNS
cord-267897-w4pbq2lb	42	32	)	)	-RRB-
cord-267897-w4pbq2lb	42	33	strongly	strongly	RB
cord-267897-w4pbq2lb	42	34	influence	influence	VBP
cord-267897-w4pbq2lb	42	35	the	the	DT
cord-267897-w4pbq2lb	42	36	results	result	NNS
cord-267897-w4pbq2lb	42	37	.	.	.
cord-267897-w4pbq2lb	43	1	10	10	CD
cord-267897-w4pbq2lb	43	2	,	,	,
cord-267897-w4pbq2lb	43	3	11	11	CD
cord-267897-w4pbq2lb	43	4	Anions	Anions	NNPS
cord-267897-w4pbq2lb	43	5	present	present	JJ
cord-267897-w4pbq2lb	43	6	at	at	IN
cord-267897-w4pbq2lb	43	7	the	the	DT
cord-267897-w4pbq2lb	43	8	time	time	NN
cord-267897-w4pbq2lb	43	9	of	of	IN
cord-267897-w4pbq2lb	43	10	preparation	preparation	NN
cord-267897-w4pbq2lb	43	11	may	may	MD
cord-267897-w4pbq2lb	43	12	coprecipitate	coprecipitate	VB
cord-267897-w4pbq2lb	43	13	and	and	CC
cord-267897-w4pbq2lb	43	14	change	change	VB
cord-267897-w4pbq2lb	43	15	the	the	DT
cord-267897-w4pbq2lb	43	16	characteristics	characteristic	NNS
cord-267897-w4pbq2lb	43	17	from	from	IN
cord-267897-w4pbq2lb	43	18	those	those	DT
cord-267897-w4pbq2lb	43	19	of	of	IN
cord-267897-w4pbq2lb	43	20	"	"	``
cord-267897-w4pbq2lb	43	21	pure	pure	JJ
cord-267897-w4pbq2lb	43	22	"	"	''
cord-267897-w4pbq2lb	43	23	aluminum	aluminum	NN
cord-267897-w4pbq2lb	43	24	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	43	25	.	.	.
cord-267897-w4pbq2lb	44	1	Aluminum	aluminum	NN
cord-267897-w4pbq2lb	44	2	phosphate	phosphate	NN
cord-267897-w4pbq2lb	44	3	gel	gel	NN
cord-267897-w4pbq2lb	44	4	can	can	MD
cord-267897-w4pbq2lb	44	5	be	be	VB
cord-267897-w4pbq2lb	44	6	seen	see	VBN
cord-267897-w4pbq2lb	44	7	as	as	IN
cord-267897-w4pbq2lb	44	8	an	an	DT
cord-267897-w4pbq2lb	44	9	example	example	NN
cord-267897-w4pbq2lb	44	10	of	of	IN
cord-267897-w4pbq2lb	44	11	such	such	PDT
cord-267897-w4pbq2lb	44	12	a	a	DT
cord-267897-w4pbq2lb	44	13	preparation	preparation	NN
cord-267897-w4pbq2lb	44	14	where	where	WRB
cord-267897-w4pbq2lb	44	15	the	the	DT
cord-267897-w4pbq2lb	44	16	soluble	soluble	JJ
cord-267897-w4pbq2lb	44	17	aluminum	aluminum	NN
cord-267897-w4pbq2lb	44	18	salts	salt	NNS
cord-267897-w4pbq2lb	44	19	are	be	VBP
cord-267897-w4pbq2lb	44	20	precipitated	precipitate	VBN
cord-267897-w4pbq2lb	44	21	in	in	IN
cord-267897-w4pbq2lb	44	22	the	the	DT
cord-267897-w4pbq2lb	44	23	presence	presence	NN
cord-267897-w4pbq2lb	44	24	of	of	IN
cord-267897-w4pbq2lb	44	25	sufficient	sufficient	JJ
cord-267897-w4pbq2lb	44	26	amounts	amount	NNS
cord-267897-w4pbq2lb	44	27	of	of	IN
cord-267897-w4pbq2lb	44	28	phosphate	phosphate	NN
cord-267897-w4pbq2lb	44	29	ions	ion	NNS
cord-267897-w4pbq2lb	44	30	.	.	.
cord-267897-w4pbq2lb	45	1	X	x	NN
cord-267897-w4pbq2lb	45	2	-	-	NN
cord-267897-w4pbq2lb	45	3	ray	ray	NN
cord-267897-w4pbq2lb	45	4	microanalysis	microanalysis	NN
cord-267897-w4pbq2lb	45	5	(	(	-LRB-
cord-267897-w4pbq2lb	45	6	Fig	Fig	NNP
cord-267897-w4pbq2lb	45	7	.	.	.
cord-267897-w4pbq2lb	45	8	18.1	18.1	CD
cord-267897-w4pbq2lb	45	9	)	)	-RRB-
cord-267897-w4pbq2lb	45	10	is	be	VBZ
cord-267897-w4pbq2lb	45	11	a	a	DT
cord-267897-w4pbq2lb	45	12	way	way	NN
cord-267897-w4pbq2lb	45	13	to	to	TO
cord-267897-w4pbq2lb	45	14	obtain	obtain	VB
cord-267897-w4pbq2lb	45	15	a	a	DT
cord-267897-w4pbq2lb	45	16	ground	ground	NN
cord-267897-w4pbq2lb	45	17	element	element	NN
cord-267897-w4pbq2lb	45	18	"	"	``
cord-267897-w4pbq2lb	45	19	fingerprinting	fingerprinting	NN
cord-267897-w4pbq2lb	45	20	"	"	''
cord-267897-w4pbq2lb	45	21	of	of	IN
cord-267897-w4pbq2lb	45	22	mineral	mineral	NN
cord-267897-w4pbq2lb	45	23	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	45	24	preparations	preparation	NNS
cord-267897-w4pbq2lb	45	25	giving	give	VBG
cord-267897-w4pbq2lb	45	26	an	an	DT
cord-267897-w4pbq2lb	45	27	indication	indication	NN
cord-267897-w4pbq2lb	45	28	of	of	IN
cord-267897-w4pbq2lb	45	29	which	which	WDT
cord-267897-w4pbq2lb	45	30	salts	salt	NNS
cord-267897-w4pbq2lb	45	31	were	be	VBD
cord-267897-w4pbq2lb	45	32	used	use	VBN
cord-267897-w4pbq2lb	45	33	as	as	IN
cord-267897-w4pbq2lb	45	34	starting	start	VBG
cord-267897-w4pbq2lb	45	35	material	material	NN
cord-267897-w4pbq2lb	45	36	in	in	IN
cord-267897-w4pbq2lb	45	37	the	the	DT
cord-267897-w4pbq2lb	45	38	preparation	preparation	NN
cord-267897-w4pbq2lb	45	39	.	.	.
cord-267897-w4pbq2lb	46	1	Stanley	Stanley	NNP
cord-267897-w4pbq2lb	46	2	Hem	Hem	NNP
cord-267897-w4pbq2lb	46	3	's	's	POS
cord-267897-w4pbq2lb	46	4	group	group	NN
cord-267897-w4pbq2lb	46	5	at	at	IN
cord-267897-w4pbq2lb	46	6	Purdue	Purdue	NNP
cord-267897-w4pbq2lb	46	7	University	University	NNP
cord-267897-w4pbq2lb	46	8	studied	study	VBD
cord-267897-w4pbq2lb	46	9	the	the	DT
cord-267897-w4pbq2lb	46	10	physicochemical	physicochemical	JJ
cord-267897-w4pbq2lb	46	11	nature	nature	NN
cord-267897-w4pbq2lb	46	12	of	of	IN
cord-267897-w4pbq2lb	46	13	inorganic	inorganic	JJ
cord-267897-w4pbq2lb	46	14	mineral	mineral	NN
cord-267897-w4pbq2lb	46	15	gel	gel	NN
cord-267897-w4pbq2lb	46	16	preparations	preparation	NNS
cord-267897-w4pbq2lb	46	17	commonly	commonly	RB
cord-267897-w4pbq2lb	46	18	used	use	VBN
cord-267897-w4pbq2lb	46	19	as	as	IN
cord-267897-w4pbq2lb	46	20	vaccine	vaccine	NN
cord-267897-w4pbq2lb	46	21	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	46	22	for	for	IN
cord-267897-w4pbq2lb	46	23	more	more	JJR
cord-267897-w4pbq2lb	46	24	than	than	IN
cord-267897-w4pbq2lb	46	25	25	25	CD
cord-267897-w4pbq2lb	46	26	years	year	NNS
cord-267897-w4pbq2lb	46	27	.	.	.
cord-267897-w4pbq2lb	47	1	Using	use	VBG
cord-267897-w4pbq2lb	47	2	X	x	NN
cord-267897-w4pbq2lb	47	3	-	-	NN
cord-267897-w4pbq2lb	47	4	ray	ray	NN
cord-267897-w4pbq2lb	47	5	crystallography	crystallography	NN
cord-267897-w4pbq2lb	47	6	and	and	CC
cord-267897-w4pbq2lb	47	7	infrared	infrared	JJ
cord-267897-w4pbq2lb	47	8	spectroscopy	spectroscopy	NN
cord-267897-w4pbq2lb	47	9	they	-PRON-	PRP
cord-267897-w4pbq2lb	47	10	demonstrated	demonstrate	VBD
cord-267897-w4pbq2lb	47	11	a	a	DT
cord-267897-w4pbq2lb	47	12	boehmite	boehmite	NNP
cord-267897-w4pbq2lb	47	13	-	-	HYPH
cord-267897-w4pbq2lb	47	14	like	like	JJ
cord-267897-w4pbq2lb	47	15	(	(	-LRB-
cord-267897-w4pbq2lb	47	16	aluminum	aluminum	NN
cord-267897-w4pbq2lb	47	17	oxyhydroxide	oxyhydroxide	NN
cord-267897-w4pbq2lb	47	18	,	,	,
cord-267897-w4pbq2lb	47	19	AlOOH	AlOOH	NNP
cord-267897-w4pbq2lb	47	20	)	)	-RRB-
cord-267897-w4pbq2lb	47	21	pattern	pattern	NN
cord-267897-w4pbq2lb	47	22	in	in	IN
cord-267897-w4pbq2lb	47	23	preparations	preparation	NNS
cord-267897-w4pbq2lb	47	24	traditionally	traditionally	RB
cord-267897-w4pbq2lb	47	25	known	know	VBN
cord-267897-w4pbq2lb	47	26	as	as	IN
cord-267897-w4pbq2lb	47	27	aluminum	aluminum	NN
cord-267897-w4pbq2lb	47	28	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	47	29	,	,	,
cord-267897-w4pbq2lb	47	30	whereas	whereas	IN
cord-267897-w4pbq2lb	47	31	commercialized	commercialize	VBN
cord-267897-w4pbq2lb	47	32	aluminum	aluminum	NN
cord-267897-w4pbq2lb	47	33	phosphate	phosphate	NN
cord-267897-w4pbq2lb	47	34	gel	gel	NN
cord-267897-w4pbq2lb	47	35	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	47	36	was	be	VBD
cord-267897-w4pbq2lb	47	37	identified	identify	VBN
cord-267897-w4pbq2lb	47	38	as	as	IN
cord-267897-w4pbq2lb	47	39	amorphous	amorphous	JJ
cord-267897-w4pbq2lb	47	40	aluminum	aluminum	NN
cord-267897-w4pbq2lb	47	41	hydroxyphosphate	hydroxyphosphate	NNP
cord-267897-w4pbq2lb	47	42	.	.	.
cord-267897-w4pbq2lb	48	1	12	12	CD
cord-267897-w4pbq2lb	49	1	It	-PRON-	PRP
cord-267897-w4pbq2lb	49	2	was	be	VBD
cord-267897-w4pbq2lb	49	3	possible	possible	JJ
cord-267897-w4pbq2lb	49	4	to	to	TO
cord-267897-w4pbq2lb	49	5	calculate	calculate	VB
cord-267897-w4pbq2lb	49	6	an	an	DT
cord-267897-w4pbq2lb	49	7	average	average	JJ
cord-267897-w4pbq2lb	49	8	primary	primary	JJ
cord-267897-w4pbq2lb	49	9	crystallite	crystallite	NN
cord-267897-w4pbq2lb	49	10	size	size	NN
cord-267897-w4pbq2lb	49	11	of	of	IN
cord-267897-w4pbq2lb	49	12	4.5	4.5	CD
cord-267897-w4pbq2lb	49	13	Â	â	CD
cord-267897-w4pbq2lb	49	14	2.2	2.2	CD
cord-267897-w4pbq2lb	49	15	Â	â	CD
cord-267897-w4pbq2lb	49	16	10	10	CD
cord-267897-w4pbq2lb	49	17	nm	nm	NN
cord-267897-w4pbq2lb	49	18	for	for	IN
cord-267897-w4pbq2lb	49	19	the	the	DT
cord-267897-w4pbq2lb	49	20	boehmite	boehmite	NNP
cord-267897-w4pbq2lb	49	21	preparations	preparation	NNS
cord-267897-w4pbq2lb	49	22	.	.	.
cord-267897-w4pbq2lb	50	1	13	13	CD
cord-267897-w4pbq2lb	51	1	Commercially	commercially	RB
cord-267897-w4pbq2lb	51	2	available	available	JJ
cord-267897-w4pbq2lb	51	3	calcium	calcium	NN
cord-267897-w4pbq2lb	51	4	phosphate	phosphate	NN
cord-267897-w4pbq2lb	51	5	(	(	-LRB-
cord-267897-w4pbq2lb	51	6	from	from	IN
cord-267897-w4pbq2lb	51	7	REHEIS	REHEIS	NNP
cord-267897-w4pbq2lb	51	8	Inc.	Inc.	NNP
cord-267897-w4pbq2lb	51	9	NJ	NJ	NNP
cord-267897-w4pbq2lb	51	10	,	,	,
cord-267897-w4pbq2lb	51	11	USA	USA	NNP
cord-267897-w4pbq2lb	51	12	)	)	-RRB-
cord-267897-w4pbq2lb	51	13	was	be	VBD
cord-267897-w4pbq2lb	51	14	studied	study	VBN
cord-267897-w4pbq2lb	51	15	by	by	IN
cord-267897-w4pbq2lb	51	16	X	x	NN
cord-267897-w4pbq2lb	51	17	-	-	NN
cord-267897-w4pbq2lb	51	18	ray	ray	NN
cord-267897-w4pbq2lb	51	19	diffraction	diffraction	NN
cord-267897-w4pbq2lb	51	20	,	,	,
cord-267897-w4pbq2lb	51	21	Fourier	Fourier	NNP
cord-267897-w4pbq2lb	51	22	transform	transform	VB
cord-267897-w4pbq2lb	51	23	infrared	infrared	JJ
cord-267897-w4pbq2lb	51	24	spectroscopy	spectroscopy	NN
cord-267897-w4pbq2lb	51	25	,	,	,
cord-267897-w4pbq2lb	51	26	and	and	CC
cord-267897-w4pbq2lb	51	27	thermal	thermal	JJ
cord-267897-w4pbq2lb	51	28	analysis	analysis	NN
cord-267897-w4pbq2lb	51	29	.	.	.
cord-267897-w4pbq2lb	52	1	This	this	DT
cord-267897-w4pbq2lb	52	2	indicated	indicate	VBD
cord-267897-w4pbq2lb	52	3	that	that	IN
cord-267897-w4pbq2lb	52	4	calcium	calcium	NN
cord-267897-w4pbq2lb	52	5	phosphate	phosphate	NN
cord-267897-w4pbq2lb	52	6	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	52	7	with	with	IN
cord-267897-w4pbq2lb	52	8	the	the	DT
cord-267897-w4pbq2lb	52	9	suggested	suggest	VBN
cord-267897-w4pbq2lb	52	10	formula	formula	NN
cord-267897-w4pbq2lb	52	11	of	of	IN
cord-267897-w4pbq2lb	52	12	Ca	Ca	NNP
cord-267897-w4pbq2lb	52	13	3	3	CD
cord-267897-w4pbq2lb	52	14	(	(	-LRB-
cord-267897-w4pbq2lb	52	15	PO	PO	NNP
cord-267897-w4pbq2lb	52	16	4	4	CD
cord-267897-w4pbq2lb	52	17	)	)	-RRB-
cord-267897-w4pbq2lb	52	18	2	2	CD
cord-267897-w4pbq2lb	52	19	could	could	MD
cord-267897-w4pbq2lb	52	20	be	be	VB
cord-267897-w4pbq2lb	52	21	described	describe	VBN
cord-267897-w4pbq2lb	52	22	as	as	IN
cord-267897-w4pbq2lb	52	23	nonstoichiometric	nonstoichiometric	NNP
cord-267897-w4pbq2lb	52	24	hydroxyapatite	hydroxyapatite	NN
cord-267897-w4pbq2lb	52	25	,	,	,
cord-267897-w4pbq2lb	52	26	Ca	Ca	NNP
cord-267897-w4pbq2lb	52	27	10Àx	10Àx	NNP
cord-267897-w4pbq2lb	52	28	(	(	-LRB-
cord-267897-w4pbq2lb	52	29	HPO	HPO	NNP
cord-267897-w4pbq2lb	52	30	4	4	CD
cord-267897-w4pbq2lb	52	31	)	)	-RRB-
cord-267897-w4pbq2lb	53	1	x	x	LS
cord-267897-w4pbq2lb	54	1	(	(	-LRB-
cord-267897-w4pbq2lb	54	2	PO	PO	NNP
cord-267897-w4pbq2lb	54	3	4	4	CD
cord-267897-w4pbq2lb	54	4	)	)	-RRB-
cord-267897-w4pbq2lb	55	1	6Àx	6àx	CD
cord-267897-w4pbq2lb	56	1	(	(	-LRB-
cord-267897-w4pbq2lb	56	2	OH	oh	UH
cord-267897-w4pbq2lb	56	3	)	)	-RRB-
cord-267897-w4pbq2lb	56	4	2Àx	2àx	XX
cord-267897-w4pbq2lb	56	5	,	,	,
cord-267897-w4pbq2lb	56	6	where	where	WRB
cord-267897-w4pbq2lb	56	7	x	x	NN
cord-267897-w4pbq2lb	56	8	varies	vary	VBZ
cord-267897-w4pbq2lb	56	9	from	from	IN
cord-267897-w4pbq2lb	56	10	0	0	CD
cord-267897-w4pbq2lb	56	11	to	to	IN
cord-267897-w4pbq2lb	56	12	2	2	CD
cord-267897-w4pbq2lb	56	13	.	.	.
cord-267897-w4pbq2lb	56	14	14	14	CD
cord-267897-w4pbq2lb	57	1	In	in	IN
cord-267897-w4pbq2lb	57	2	the	the	DT
cord-267897-w4pbq2lb	57	3	original	original	JJ
cord-267897-w4pbq2lb	57	4	work	work	NN
cord-267897-w4pbq2lb	57	5	,	,	,
cord-267897-w4pbq2lb	57	6	Relyveld	Relyveld	NNP
cord-267897-w4pbq2lb	57	7	described	describe	VBD
cord-267897-w4pbq2lb	57	8	the	the	DT
cord-267897-w4pbq2lb	57	9	calcium	calcium	NN
cord-267897-w4pbq2lb	57	10	phosphate	phosphate	NN
cord-267897-w4pbq2lb	57	11	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	57	12	,	,	,
cord-267897-w4pbq2lb	57	13	prepared	prepare	VBN
cord-267897-w4pbq2lb	57	14	at	at	IN
cord-267897-w4pbq2lb	57	15	the	the	DT
cord-267897-w4pbq2lb	57	16	Institut	Institut	NNP
cord-267897-w4pbq2lb	57	17	Pasteur	Pasteur	NNP
cord-267897-w4pbq2lb	57	18	,	,	,
cord-267897-w4pbq2lb	57	19	as	as	IN
cord-267897-w4pbq2lb	57	20	non	non	JJ
cord-267897-w4pbq2lb	57	21	-	-	JJ
cord-267897-w4pbq2lb	57	22	hydroxyapatite	hydroxyapatite	JJ
cord-267897-w4pbq2lb	57	23	(	(	-LRB-
cord-267897-w4pbq2lb	57	24	Relyveld	Relyveld	NNP
cord-267897-w4pbq2lb	57	25	,	,	,
cord-267897-w4pbq2lb	57	26	personal	personal	JJ
cord-267897-w4pbq2lb	57	27	communication	communication	NN
cord-267897-w4pbq2lb	57	28	Morphological	morphological	JJ
cord-267897-w4pbq2lb	57	29	studies	study	NNS
cord-267897-w4pbq2lb	57	30	using	use	VBG
cord-267897-w4pbq2lb	57	31	scanning	scan	VBG
cord-267897-w4pbq2lb	57	32	electron	electron	NN
cord-267897-w4pbq2lb	57	33	microscopy	microscopy	NN
cord-267897-w4pbq2lb	57	34	(	(	-LRB-
cord-267897-w4pbq2lb	57	35	SEM	SEM	NNP
cord-267897-w4pbq2lb	57	36	)	)	-RRB-
cord-267897-w4pbq2lb	57	37	have	have	VBP
cord-267897-w4pbq2lb	57	38	been	be	VBN
cord-267897-w4pbq2lb	57	39	performed	perform	VBN
cord-267897-w4pbq2lb	57	40	(	(	-LRB-
cord-267897-w4pbq2lb	57	41	Fig	Fig	NNP
cord-267897-w4pbq2lb	57	42	.	.	.
cord-267897-w4pbq2lb	57	43	18	18	CD
cord-267897-w4pbq2lb	57	44	.2	.2	CD
cord-267897-w4pbq2lb	57	45	)	)	-RRB-
cord-267897-w4pbq2lb	57	46	.	.	.
cord-267897-w4pbq2lb	58	1	It	-PRON-	PRP
cord-267897-w4pbq2lb	58	2	should	should	MD
cord-267897-w4pbq2lb	58	3	,	,	,
cord-267897-w4pbq2lb	58	4	however	however	RB
cord-267897-w4pbq2lb	58	5	,	,	,
cord-267897-w4pbq2lb	58	6	be	be	VB
cord-267897-w4pbq2lb	58	7	remembered	remember	VBN
cord-267897-w4pbq2lb	58	8	that	that	DT
cord-267897-w4pbq2lb	58	9	dehydration	dehydration	NN
cord-267897-w4pbq2lb	58	10	of	of	IN
cord-267897-w4pbq2lb	58	11	the	the	DT
cord-267897-w4pbq2lb	58	12	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	58	13	particles	particle	NNS
cord-267897-w4pbq2lb	58	14	in	in	IN
cord-267897-w4pbq2lb	58	15	the	the	DT
cord-267897-w4pbq2lb	58	16	preparation	preparation	NN
cord-267897-w4pbq2lb	58	17	for	for	IN
cord-267897-w4pbq2lb	58	18	SEM	SEM	NNP
cord-267897-w4pbq2lb	58	19	may	may	MD
cord-267897-w4pbq2lb	58	20	lead	lead	VB
cord-267897-w4pbq2lb	58	21	to	to	IN
cord-267897-w4pbq2lb	58	22	structures	structure	NNS
cord-267897-w4pbq2lb	58	23	not	not	RB
cord-267897-w4pbq2lb	58	24	completely	completely	RB
cord-267897-w4pbq2lb	58	25	identical	identical	JJ
cord-267897-w4pbq2lb	58	26	to	to	IN
cord-267897-w4pbq2lb	58	27	those	those	DT
cord-267897-w4pbq2lb	58	28	presented	present	VBN
cord-267897-w4pbq2lb	58	29	to	to	IN
cord-267897-w4pbq2lb	58	30	the	the	DT
cord-267897-w4pbq2lb	58	31	immune	immune	JJ
cord-267897-w4pbq2lb	58	32	system	system	NN
cord-267897-w4pbq2lb	58	33	as	as	IN
cord-267897-w4pbq2lb	58	34	vaccine	vaccine	NN
cord-267897-w4pbq2lb	58	35	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	58	36	.	.	.
cord-267897-w4pbq2lb	59	1	In	in	IN
cord-267897-w4pbq2lb	59	2	human	human	JJ
cord-267897-w4pbq2lb	59	3	vaccination	vaccination	NN
cord-267897-w4pbq2lb	59	4	,	,	,
cord-267897-w4pbq2lb	59	5	aluminum	aluminum	NN
cord-267897-w4pbq2lb	59	6	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	59	7	have	have	VBP
cord-267897-w4pbq2lb	59	8	been	be	VBN
cord-267897-w4pbq2lb	59	9	primarily	primarily	RB
cord-267897-w4pbq2lb	59	10	used	use	VBN
cord-267897-w4pbq2lb	59	11	in	in	IN
cord-267897-w4pbq2lb	59	12	tetanus	tetanus	NN
cord-267897-w4pbq2lb	59	13	,	,	,
cord-267897-w4pbq2lb	59	14	diphtheria	diphtheria	NN
cord-267897-w4pbq2lb	59	15	,	,	,
cord-267897-w4pbq2lb	59	16	pertussis	pertussis	NN
cord-267897-w4pbq2lb	59	17	,	,	,
cord-267897-w4pbq2lb	59	18	and	and	CC
cord-267897-w4pbq2lb	59	19	poliomyelitis	poliomyelitis	NN
cord-267897-w4pbq2lb	59	20	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	59	21	as	as	IN
cord-267897-w4pbq2lb	59	22	part	part	NN
cord-267897-w4pbq2lb	59	23	of	of	IN
cord-267897-w4pbq2lb	59	24	standard	standard	JJ
cord-267897-w4pbq2lb	59	25	childhood	childhood	NN
cord-267897-w4pbq2lb	59	26	vaccination	vaccination	NN
cord-267897-w4pbq2lb	59	27	programs	program	NNS
cord-267897-w4pbq2lb	59	28	for	for	IN
cord-267897-w4pbq2lb	59	29	more	more	JJR
cord-267897-w4pbq2lb	59	30	than	than	IN
cord-267897-w4pbq2lb	59	31	60	60	CD
cord-267897-w4pbq2lb	59	32	years	year	NNS
cord-267897-w4pbq2lb	59	33	in	in	IN
cord-267897-w4pbq2lb	59	34	many	many	JJ
cord-267897-w4pbq2lb	59	35	countries	country	NNS
cord-267897-w4pbq2lb	59	36	.	.	.
cord-267897-w4pbq2lb	60	1	Later	later	RB
cord-267897-w4pbq2lb	60	2	,	,	,
cord-267897-w4pbq2lb	60	3	aluminum	aluminum	NN
cord-267897-w4pbq2lb	60	4	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	60	5	were	be	VBD
cord-267897-w4pbq2lb	60	6	also	also	RB
cord-267897-w4pbq2lb	60	7	introduced	introduce	VBN
cord-267897-w4pbq2lb	60	8	in	in	IN
cord-267897-w4pbq2lb	60	9	hepatitis	hepatitis	NNP
cord-267897-w4pbq2lb	60	10	A	A	NNP
cord-267897-w4pbq2lb	60	11	and	and	CC
cord-267897-w4pbq2lb	60	12	hepatitis	hepatitis	NN
cord-267897-w4pbq2lb	60	13	B	B	NNP
cord-267897-w4pbq2lb	60	14	virus	virus	NN
cord-267897-w4pbq2lb	60	15	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	60	16	,	,	,
cord-267897-w4pbq2lb	60	17	as	as	RB
cord-267897-w4pbq2lb	60	18	well	well	RB
cord-267897-w4pbq2lb	60	19	as	as	IN
cord-267897-w4pbq2lb	60	20	in	in	IN
cord-267897-w4pbq2lb	60	21	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	60	22	against	against	IN
cord-267897-w4pbq2lb	60	23	human	human	JJ
cord-267897-w4pbq2lb	60	24	papillomavirus	papillomavirus	NN
cord-267897-w4pbq2lb	60	25	(	(	-LRB-
cord-267897-w4pbq2lb	60	26	causing	cause	VBG
cord-267897-w4pbq2lb	60	27	genital	genital	JJ
cord-267897-w4pbq2lb	60	28	warts	wart	NNS
cord-267897-w4pbq2lb	60	29	and	and	CC
cord-267897-w4pbq2lb	60	30	cervical	cervical	JJ
cord-267897-w4pbq2lb	60	31	cancers	cancer	NNS
cord-267897-w4pbq2lb	60	32	)	)	-RRB-
cord-267897-w4pbq2lb	60	33	,	,	,
cord-267897-w4pbq2lb	60	34	and	and	CC
cord-267897-w4pbq2lb	60	35	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	60	36	against	against	IN
cord-267897-w4pbq2lb	60	37	Lyme	Lyme	NNP
cord-267897-w4pbq2lb	60	38	disease	disease	NN
cord-267897-w4pbq2lb	60	39	/	/	,
cord-267897-w4pbq2lb	60	40	Borreliose	Borreliose	NNP
cord-267897-w4pbq2lb	60	41	and	and	CC
cord-267897-w4pbq2lb	60	42	Japanese	Japanese	NNP
cord-267897-w4pbq2lb	60	43	encephalitis	encephalitis	RB
cord-267897-w4pbq2lb	60	44	.	.	.
cord-267897-w4pbq2lb	61	1	Other	other	JJ
cord-267897-w4pbq2lb	61	2	aluminum	aluminum	NN
cord-267897-w4pbq2lb	61	3	-	-	HYPH
cord-267897-w4pbq2lb	61	4	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	61	5	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	61	6	,	,	,
cord-267897-w4pbq2lb	61	7	against	against	IN
cord-267897-w4pbq2lb	61	8	,	,	,
cord-267897-w4pbq2lb	61	9	e.g.	e.g.	RB
cord-267897-w4pbq2lb	61	10	,	,	,
cord-267897-w4pbq2lb	61	11	anthrax	anthrax	NN
cord-267897-w4pbq2lb	61	12	,	,	,
cord-267897-w4pbq2lb	61	13	are	be	VBP
cord-267897-w4pbq2lb	61	14	available	available	JJ
cord-267897-w4pbq2lb	61	15	for	for	IN
cord-267897-w4pbq2lb	61	16	special	special	JJ
cord-267897-w4pbq2lb	61	17	risk	risk	NN
cord-267897-w4pbq2lb	61	18	groups	group	NNS
cord-267897-w4pbq2lb	61	19	(	(	-LRB-
cord-267897-w4pbq2lb	61	20	Table	table	NN
cord-267897-w4pbq2lb	61	21	18	18	CD
cord-267897-w4pbq2lb	61	22	.1	.1	CD
cord-267897-w4pbq2lb	61	23	)	)	-RRB-
cord-267897-w4pbq2lb	61	24	.	.	.
cord-267897-w4pbq2lb	62	1	In	in	IN
cord-267897-w4pbq2lb	62	2	veterinary	veterinary	JJ
cord-267897-w4pbq2lb	62	3	medicine	medicine	NN
cord-267897-w4pbq2lb	62	4	,	,	,
cord-267897-w4pbq2lb	62	5	aluminum	aluminum	NN
cord-267897-w4pbq2lb	62	6	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	62	7	have	have	VBP
cord-267897-w4pbq2lb	62	8	been	be	VBN
cord-267897-w4pbq2lb	62	9	used	use	VBN
cord-267897-w4pbq2lb	62	10	in	in	IN
cord-267897-w4pbq2lb	62	11	a	a	DT
cord-267897-w4pbq2lb	62	12	large	large	JJ
cord-267897-w4pbq2lb	62	13	number	number	NN
cord-267897-w4pbq2lb	62	14	of	of	IN
cord-267897-w4pbq2lb	62	15	vaccine	vaccine	NN
cord-267897-w4pbq2lb	62	16	formulations	formulation	NNS
cord-267897-w4pbq2lb	62	17	against	against	IN
cord-267897-w4pbq2lb	62	18	viral	viral	JJ
cord-267897-w4pbq2lb	62	19	15e19	15e19	CD
cord-267897-w4pbq2lb	62	20	and	and	CC
cord-267897-w4pbq2lb	62	21	bacterial	bacterial	JJ
cord-267897-w4pbq2lb	62	22	diseases	disease	NNS
cord-267897-w4pbq2lb	63	1	20e23	20e23	CD
cord-267897-w4pbq2lb	64	1	(	(	-LRB-
cord-267897-w4pbq2lb	64	2	Table	Table	NNP
cord-267897-w4pbq2lb	64	3	18	18	CD
cord-267897-w4pbq2lb	64	4	.	.	.
cord-267897-w4pbq2lb	64	5	2	2	LS
cord-267897-w4pbq2lb	64	6	)	)	-RRB-
cord-267897-w4pbq2lb	64	7	,	,	,
cord-267897-w4pbq2lb	64	8	as	as	RB
cord-267897-w4pbq2lb	64	9	well	well	RB
cord-267897-w4pbq2lb	64	10	as	as	IN
cord-267897-w4pbq2lb	64	11	in	in	IN
cord-267897-w4pbq2lb	64	12	attempts	attempt	NNS
cord-267897-w4pbq2lb	64	13	to	to	TO
cord-267897-w4pbq2lb	64	14	make	make	VB
cord-267897-w4pbq2lb	64	15	antiparasite	antiparasite	NNP
cord-267897-w4pbq2lb	64	16	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	64	17	.	.	.
cord-267897-w4pbq2lb	65	1	24e26	24e26	CD
cord-267897-w4pbq2lb	65	2	Calcium	calcium	NN
cord-267897-w4pbq2lb	65	3	phosphate	phosphate	NN
cord-267897-w4pbq2lb	65	4	was	be	VBD
cord-267897-w4pbq2lb	65	5	used	use	VBN
cord-267897-w4pbq2lb	65	6	as	as	IN
cord-267897-w4pbq2lb	65	7	an	an	DT
cord-267897-w4pbq2lb	65	8	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	65	9	in	in	IN
cord-267897-w4pbq2lb	65	10	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	65	11	against	against	IN
cord-267897-w4pbq2lb	65	12	diphtheria	diphtheria	NN
cord-267897-w4pbq2lb	65	13	,	,	,
cord-267897-w4pbq2lb	65	14	tetanus	tetanus	NN
cord-267897-w4pbq2lb	65	15	,	,	,
cord-267897-w4pbq2lb	65	16	Bordetella	Bordetella	NNP
cord-267897-w4pbq2lb	65	17	pertussis	pertussis	NN
cord-267897-w4pbq2lb	65	18	,	,	,
cord-267897-w4pbq2lb	65	19	and	and	CC
cord-267897-w4pbq2lb	65	20	poliomyelitis	poliomyelitis	NN
cord-267897-w4pbq2lb	65	21	,	,	,
cord-267897-w4pbq2lb	65	22	27,28	27,28	CD
cord-267897-w4pbq2lb	65	23	commercialized	commercialize	VBN
cord-267897-w4pbq2lb	65	24	by	by	IN
cord-267897-w4pbq2lb	65	25	Institut	Institut	NNP
cord-267897-w4pbq2lb	65	26	Pasteur	Pasteur	NNP
cord-267897-w4pbq2lb	65	27	.	.	.
cord-267897-w4pbq2lb	66	1	Calcium	calcium	NN
cord-267897-w4pbq2lb	66	2	phosphate	phosphate	NN
cord-267897-w4pbq2lb	66	3	was	be	VBD
cord-267897-w4pbq2lb	66	4	used	use	VBN
cord-267897-w4pbq2lb	66	5	as	as	IN
cord-267897-w4pbq2lb	66	6	an	an	DT
cord-267897-w4pbq2lb	66	7	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	66	8	in	in	IN
cord-267897-w4pbq2lb	66	9	the	the	DT
cord-267897-w4pbq2lb	66	10	IPAD	IPAD	NNP
cord-267897-w4pbq2lb	66	11	series	series	NN
cord-267897-w4pbq2lb	66	12	of	of	IN
cord-267897-w4pbq2lb	66	13	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	66	14	by	by	IN
cord-267897-w4pbq2lb	66	15	Institut	Institut	NNP
cord-267897-w4pbq2lb	66	16	Pasteur	Pasteur	NNP
cord-267897-w4pbq2lb	66	17	for	for	IN
cord-267897-w4pbq2lb	66	18	approximately	approximately	RB
cord-267897-w4pbq2lb	66	19	25	25	CD
cord-267897-w4pbq2lb	66	20	years	year	NNS
cord-267897-w4pbq2lb	66	21	.	.	.
cord-267897-w4pbq2lb	67	1	Furthermore	furthermore	RB
cord-267897-w4pbq2lb	67	2	,	,	,
cord-267897-w4pbq2lb	67	3	calcium	calcium	NN
cord-267897-w4pbq2lb	67	4	phosphate	phosphate	NN
cord-267897-w4pbq2lb	67	5	was	be	VBD
cord-267897-w4pbq2lb	67	6	tested	test	VBN
cord-267897-w4pbq2lb	67	7	as	as	IN
cord-267897-w4pbq2lb	67	8	an	an	DT
cord-267897-w4pbq2lb	67	9	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	67	10	in	in	IN
cord-267897-w4pbq2lb	67	11	experimental	experimental	JJ
cord-267897-w4pbq2lb	67	12	vaccine	vaccine	NN
cord-267897-w4pbq2lb	67	13	formulations	formulation	NNS
cord-267897-w4pbq2lb	67	14	with	with	IN
cord-267897-w4pbq2lb	67	15	the	the	DT
cord-267897-w4pbq2lb	67	16	gp160	gp160	NNP
cord-267897-w4pbq2lb	67	17	antigen	antigen	NN
cord-267897-w4pbq2lb	67	18	from	from	IN
cord-267897-w4pbq2lb	67	19	human	human	JJ
cord-267897-w4pbq2lb	67	20	immunodeficiency	immunodeficiency	NN
cord-267897-w4pbq2lb	67	21	virus	virus	NN
cord-267897-w4pbq2lb	67	22	.	.	.
cord-267897-w4pbq2lb	68	1	29	29	CD
cord-267897-w4pbq2lb	68	2	Calcium	calcium	NN
cord-267897-w4pbq2lb	68	3	phosphate	phosphate	NN
cord-267897-w4pbq2lb	68	4	has	have	VBZ
cord-267897-w4pbq2lb	68	5	so	so	RB
cord-267897-w4pbq2lb	68	6	far	far	RB
cord-267897-w4pbq2lb	68	7	not	not	RB
cord-267897-w4pbq2lb	68	8	been	be	VBN
cord-267897-w4pbq2lb	68	9	used	use	VBN
cord-267897-w4pbq2lb	68	10	as	as	IN
cord-267897-w4pbq2lb	68	11	an	an	DT
cord-267897-w4pbq2lb	68	12	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	68	13	in	in	IN
cord-267897-w4pbq2lb	68	14	commercial	commercial	JJ
cord-267897-w4pbq2lb	68	15	veterinary	veterinary	JJ
cord-267897-w4pbq2lb	68	16	prophylactic	prophylactic	JJ
cord-267897-w4pbq2lb	68	17	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	68	18	.	.	.
cord-267897-w4pbq2lb	69	1	Both	both	DT
cord-267897-w4pbq2lb	69	2	aluminum	aluminum	NN
cord-267897-w4pbq2lb	69	3	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	69	4	and	and	CC
cord-267897-w4pbq2lb	69	5	calcium	calcium	NN
cord-267897-w4pbq2lb	69	6	phosphate	phosphate	NN
cord-267897-w4pbq2lb	69	7	have	have	VBP
cord-267897-w4pbq2lb	69	8	been	be	VBN
cord-267897-w4pbq2lb	69	9	used	use	VBN
cord-267897-w4pbq2lb	69	10	as	as	IN
cord-267897-w4pbq2lb	69	11	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	69	12	in	in	IN
cord-267897-w4pbq2lb	69	13	commercialized	commercialized	JJ
cord-267897-w4pbq2lb	69	14	adsorbed	adsorbed	JJ
cord-267897-w4pbq2lb	69	15	allergen	allergen	NN
cord-267897-w4pbq2lb	69	16	preparations	preparation	NNS
cord-267897-w4pbq2lb	69	17	for	for	IN
cord-267897-w4pbq2lb	69	18	hyposensitization	hyposensitization	NN
cord-267897-w4pbq2lb	69	19	of	of	IN
cord-267897-w4pbq2lb	69	20	allergic	allergic	JJ
cord-267897-w4pbq2lb	69	21	patients	patient	NNS
cord-267897-w4pbq2lb	69	22	.	.	.
cord-267897-w4pbq2lb	70	1	30	30	CD
cord-267897-w4pbq2lb	70	2	Limitations	limitation	NNS
cord-267897-w4pbq2lb	70	3	to	to	IN
cord-267897-w4pbq2lb	70	4	the	the	DT
cord-267897-w4pbq2lb	70	5	Applicability	Applicability	NNP
cord-267897-w4pbq2lb	70	6	of	of	IN
cord-267897-w4pbq2lb	70	7	Mineral	Mineral	NNP
cord-267897-w4pbq2lb	70	8	Adjuvants	Adjuvants	NNPS
cord-267897-w4pbq2lb	71	1	One	one	CD
cord-267897-w4pbq2lb	71	2	obvious	obvious	JJ
cord-267897-w4pbq2lb	71	3	limitation	limitation	NN
cord-267897-w4pbq2lb	71	4	for	for	IN
cord-267897-w4pbq2lb	71	5	the	the	DT
cord-267897-w4pbq2lb	71	6	application	application	NN
cord-267897-w4pbq2lb	71	7	of	of	IN
cord-267897-w4pbq2lb	71	8	aluminum	aluminum	NN
cord-267897-w4pbq2lb	71	9	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	71	10	lies	lie	VBZ
cord-267897-w4pbq2lb	71	11	in	in	IN
cord-267897-w4pbq2lb	71	12	the	the	DT
cord-267897-w4pbq2lb	71	13	apparent	apparent	JJ
cord-267897-w4pbq2lb	71	14	Th2-like	th2-like	JJ
cord-267897-w4pbq2lb	71	15	profile	profile	NN
cord-267897-w4pbq2lb	71	16	of	of	IN
cord-267897-w4pbq2lb	71	17	these	these	DT
cord-267897-w4pbq2lb	71	18	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	71	19	.	.	.
cord-267897-w4pbq2lb	72	1	A	a	DT
cord-267897-w4pbq2lb	72	2	Th2-biased	th2-biased	JJ
cord-267897-w4pbq2lb	72	3	immune	immune	JJ
cord-267897-w4pbq2lb	72	4	response	response	NN
cord-267897-w4pbq2lb	72	5	is	be	VBZ
cord-267897-w4pbq2lb	72	6	not	not	RB
cord-267897-w4pbq2lb	72	7	likely	likely	JJ
cord-267897-w4pbq2lb	72	8	to	to	TO
cord-267897-w4pbq2lb	72	9	protect	protect	VB
cord-267897-w4pbq2lb	72	10	against	against	IN
cord-267897-w4pbq2lb	72	11	diseases	disease	NNS
cord-267897-w4pbq2lb	72	12	for	for	IN
cord-267897-w4pbq2lb	72	13	which	which	WDT
cord-267897-w4pbq2lb	72	14	Th1	th1	CD
cord-267897-w4pbq2lb	72	15	immunity	immunity	NN
cord-267897-w4pbq2lb	72	16	and	and	CC
cord-267897-w4pbq2lb	72	17	major	major	JJ
cord-267897-w4pbq2lb	72	18	histocompatibility	histocompatibility	NN
cord-267897-w4pbq2lb	72	19	complex	complex	NN
cord-267897-w4pbq2lb	72	20	(	(	-LRB-
cord-267897-w4pbq2lb	72	21	MHC	MHC	NNP
cord-267897-w4pbq2lb	72	22	)	)	-RRB-
cord-267897-w4pbq2lb	72	23	class	class	NN
cord-267897-w4pbq2lb	73	1	Ierestricted	Ierestricted	NNP
cord-267897-w4pbq2lb	73	2	CTLs	ctl	NNS
cord-267897-w4pbq2lb	73	3	are	be	VBP
cord-267897-w4pbq2lb	73	4	essential	essential	JJ
cord-267897-w4pbq2lb	73	5	for	for	IN
cord-267897-w4pbq2lb	73	6	protection	protection	NN
cord-267897-w4pbq2lb	73	7	,	,	,
cord-267897-w4pbq2lb	73	8	such	such	JJ
cord-267897-w4pbq2lb	73	9	as	as	IN
cord-267897-w4pbq2lb	73	10	with	with	IN
cord-267897-w4pbq2lb	73	11	,	,	,
cord-267897-w4pbq2lb	73	12	e.g.	e.g.	RB
cord-267897-w4pbq2lb	73	13	,	,	,
cord-267897-w4pbq2lb	73	14	intracellular	intracellular	JJ
cord-267897-w4pbq2lb	73	15	parasites	parasite	NNS
cord-267897-w4pbq2lb	73	16	or	or	CC
cord-267897-w4pbq2lb	73	17	tuberculosis	tuberculosis	NN
cord-267897-w4pbq2lb	73	18	.	.	.
cord-267897-w4pbq2lb	74	1	31	31	CD
cord-267897-w4pbq2lb	75	1	Another	another	DT
cord-267897-w4pbq2lb	75	2	limitation	limitation	NN
cord-267897-w4pbq2lb	75	3	lies	lie	VBZ
cord-267897-w4pbq2lb	75	4	in	in	IN
cord-267897-w4pbq2lb	75	5	the	the	DT
cord-267897-w4pbq2lb	75	6	fact	fact	NN
cord-267897-w4pbq2lb	75	7	that	that	IN
cord-267897-w4pbq2lb	75	8	traditional	traditional	JJ
cord-267897-w4pbq2lb	75	9	aluminumand	aluminumand	NN
cord-267897-w4pbq2lb	75	10	calcium	calcium	NN
cord-267897-w4pbq2lb	75	11	-	-	HYPH
cord-267897-w4pbq2lb	75	12	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	75	13	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	75	14	are	be	VBP
cord-267897-w4pbq2lb	75	15	sensitive	sensitive	JJ
cord-267897-w4pbq2lb	75	16	to	to	IN
cord-267897-w4pbq2lb	75	17	freezing	freeze	VBG
cord-267897-w4pbq2lb	75	18	and	and	CC
cord-267897-w4pbq2lb	75	19	therefore	therefore	RB
cord-267897-w4pbq2lb	75	20	not	not	RB
cord-267897-w4pbq2lb	75	21	lyophilizable	lyophilizable	JJ
cord-267897-w4pbq2lb	75	22	.	.	.
cord-267897-w4pbq2lb	76	1	Assays	assay	NNS
cord-267897-w4pbq2lb	76	2	for	for	IN
cord-267897-w4pbq2lb	76	3	the	the	DT
cord-267897-w4pbq2lb	76	4	detection	detection	NN
cord-267897-w4pbq2lb	76	5	of	of	IN
cord-267897-w4pbq2lb	76	6	damages	damage	NNS
cord-267897-w4pbq2lb	76	7	to	to	IN
cord-267897-w4pbq2lb	76	8	vaccine	vaccine	NN
cord-267897-w4pbq2lb	76	9	formulations	formulation	NNS
cord-267897-w4pbq2lb	76	10	induced	induce	VBN
cord-267897-w4pbq2lb	76	11	by	by	IN
cord-267897-w4pbq2lb	76	12	freezing	freeze	VBG
cord-267897-w4pbq2lb	76	13	have	have	VBP
cord-267897-w4pbq2lb	76	14	been	be	VBN
cord-267897-w4pbq2lb	76	15	published	publish	VBN
cord-267897-w4pbq2lb	76	16	.	.	.
cord-267897-w4pbq2lb	77	1	32	32	CD
cord-267897-w4pbq2lb	77	2	,	,	,
cord-267897-w4pbq2lb	77	3	33	33	CD
cord-267897-w4pbq2lb	77	4	Attempts	attempt	NNS
cord-267897-w4pbq2lb	77	5	have	have	VBP
cord-267897-w4pbq2lb	77	6	been	be	VBN
cord-267897-w4pbq2lb	77	7	made	make	VBN
cord-267897-w4pbq2lb	77	8	to	to	TO
cord-267897-w4pbq2lb	77	9	overcome	overcome	VB
cord-267897-w4pbq2lb	77	10	the	the	DT
cord-267897-w4pbq2lb	77	11	sensitivity	sensitivity	NN
cord-267897-w4pbq2lb	77	12	to	to	IN
cord-267897-w4pbq2lb	77	13	freezing	freeze	VBG
cord-267897-w4pbq2lb	77	14	by	by	IN
cord-267897-w4pbq2lb	77	15	adding	add	VBG
cord-267897-w4pbq2lb	77	16	lyoprotectants	lyoprotectant	NNS
cord-267897-w4pbq2lb	77	17	,	,	,
cord-267897-w4pbq2lb	77	18	such	such	JJ
cord-267897-w4pbq2lb	77	19	as	as	IN
cord-267897-w4pbq2lb	77	20	trehalose	trehalose	NNP
cord-267897-w4pbq2lb	77	21	,	,	,
cord-267897-w4pbq2lb	77	22	to	to	IN
cord-267897-w4pbq2lb	77	23	the	the	DT
cord-267897-w4pbq2lb	77	24	preparations	preparation	NNS
cord-267897-w4pbq2lb	77	25	.	.	.
cord-267897-w4pbq2lb	78	1	34	34	CD
cord-267897-w4pbq2lb	78	2	,	,	,
cord-267897-w4pbq2lb	78	3	35	35	CD
cord-267897-w4pbq2lb	78	4	Aluminum	aluminum	NN
cord-267897-w4pbq2lb	78	5	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	78	6	failed	fail	VBD
cord-267897-w4pbq2lb	78	7	to	to	TO
cord-267897-w4pbq2lb	78	8	provide	provide	VB
cord-267897-w4pbq2lb	78	9	satisfactory	satisfactory	JJ
cord-267897-w4pbq2lb	78	10	augmentation	augmentation	NN
cord-267897-w4pbq2lb	78	11	of	of	IN
cord-267897-w4pbq2lb	78	12	the	the	DT
cord-267897-w4pbq2lb	78	13	immune	immune	JJ
cord-267897-w4pbq2lb	78	14	response	response	NN
cord-267897-w4pbq2lb	78	15	against	against	IN
cord-267897-w4pbq2lb	78	16	a	a	DT
cord-267897-w4pbq2lb	78	17	number	number	NN
cord-267897-w4pbq2lb	78	18	of	of	IN
cord-267897-w4pbq2lb	78	19	infectious	infectious	JJ
cord-267897-w4pbq2lb	78	20	diseases	disease	NNS
cord-267897-w4pbq2lb	78	21	,	,	,
cord-267897-w4pbq2lb	78	22	such	such	JJ
cord-267897-w4pbq2lb	78	23	as	as	IN
cord-267897-w4pbq2lb	78	24	with	with	IN
cord-267897-w4pbq2lb	78	25	influenza	influenza	NN
cord-267897-w4pbq2lb	78	26	and	and	CC
cord-267897-w4pbq2lb	78	27	typhoid	typhoid	NN
cord-267897-w4pbq2lb	78	28	fever	fever	NN
cord-267897-w4pbq2lb	78	29	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	78	30	.	.	.
cord-267897-w4pbq2lb	79	1	36	36	CD
cord-267897-w4pbq2lb	79	2	,	,	,
cord-267897-w4pbq2lb	79	3	37	37	CD
cord-267897-w4pbq2lb	80	1	In	in	IN
cord-267897-w4pbq2lb	80	2	some	some	DT
cord-267897-w4pbq2lb	80	3	approaches	approach	NNS
cord-267897-w4pbq2lb	80	4	to	to	IN
cord-267897-w4pbq2lb	80	5	vaccine	vaccine	NN
cord-267897-w4pbq2lb	80	6	preparation	preparation	NN
cord-267897-w4pbq2lb	80	7	,	,	,
cord-267897-w4pbq2lb	80	8	aluminum	aluminum	NN
cord-267897-w4pbq2lb	80	9	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	80	10	have	have	VBP
cord-267897-w4pbq2lb	80	11	shown	show	VBN
cord-267897-w4pbq2lb	80	12	limitations	limitation	NNS
cord-267897-w4pbq2lb	80	13	in	in	IN
cord-267897-w4pbq2lb	80	14	their	-PRON-	PRP$
cord-267897-w4pbq2lb	80	15	applicability	applicability	NN
cord-267897-w4pbq2lb	80	16	in	in	IN
cord-267897-w4pbq2lb	80	17	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	80	18	based	base	VBN
cord-267897-w4pbq2lb	80	19	on	on	IN
cord-267897-w4pbq2lb	80	20	small	small	JJ
cord-267897-w4pbq2lb	80	21	-	-	HYPH
cord-267897-w4pbq2lb	80	22	sized	sized	JJ
cord-267897-w4pbq2lb	80	23	peptides	peptide	NNS
cord-267897-w4pbq2lb	80	24	.	.	.
cord-267897-w4pbq2lb	81	1	38	38	CD
cord-267897-w4pbq2lb	82	1	In	in	IN
cord-267897-w4pbq2lb	82	2	some	some	DT
cord-267897-w4pbq2lb	82	3	cases	case	NNS
cord-267897-w4pbq2lb	82	4	,	,	,
cord-267897-w4pbq2lb	82	5	e.g.	e.g.	RB
cord-267897-w4pbq2lb	82	6	,	,	,
cord-267897-w4pbq2lb	82	7	with	with	IN
cord-267897-w4pbq2lb	82	8	foot	foot	NN
cord-267897-w4pbq2lb	82	9	and	and	CC
cord-267897-w4pbq2lb	82	10	mouth	mouth	NN
cord-267897-w4pbq2lb	82	11	disease	disease	NN
cord-267897-w4pbq2lb	82	12	(	(	-LRB-
cord-267897-w4pbq2lb	82	13	FMD	FMD	NNP
cord-267897-w4pbq2lb	82	14	)	)	-RRB-
cord-267897-w4pbq2lb	82	15	virus	virus	NN
cord-267897-w4pbq2lb	82	16	peptides	peptide	NNS
cord-267897-w4pbq2lb	82	17	,	,	,
cord-267897-w4pbq2lb	82	18	the	the	DT
cord-267897-w4pbq2lb	82	19	problem	problem	NN
cord-267897-w4pbq2lb	82	20	could	could	MD
cord-267897-w4pbq2lb	82	21	be	be	VB
cord-267897-w4pbq2lb	82	22	overcome	overcome	VBN
cord-267897-w4pbq2lb	82	23	by	by	IN
cord-267897-w4pbq2lb	82	24	conjugating	conjugate	VBG
cord-267897-w4pbq2lb	82	25	the	the	DT
cord-267897-w4pbq2lb	82	26	peptide	peptide	NN
cord-267897-w4pbq2lb	82	27	to	to	IN
cord-267897-w4pbq2lb	82	28	a	a	DT
cord-267897-w4pbq2lb	82	29	larger	large	JJR
cord-267897-w4pbq2lb	82	30	carrier	carrier	NN
cord-267897-w4pbq2lb	82	31	molecule	molecule	NN
cord-267897-w4pbq2lb	82	32	.	.	.
cord-267897-w4pbq2lb	83	1	39	39	CD
cord-267897-w4pbq2lb	84	1	In	in	IN
cord-267897-w4pbq2lb	84	2	others	other	NNS
cord-267897-w4pbq2lb	84	3	,	,	,
cord-267897-w4pbq2lb	84	4	it	-PRON-	PRP
cord-267897-w4pbq2lb	84	5	could	could	MD
cord-267897-w4pbq2lb	84	6	not	not	RB
cord-267897-w4pbq2lb	84	7	.	.	.
cord-267897-w4pbq2lb	85	1	40	40	CD
cord-267897-w4pbq2lb	85	2	,	,	,
cord-267897-w4pbq2lb	85	3	41	41	CD
cord-267897-w4pbq2lb	85	4	Aluminum	aluminum	NN
cord-267897-w4pbq2lb	85	5	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	85	6	have	have	VBP
cord-267897-w4pbq2lb	85	7	been	be	VBN
cord-267897-w4pbq2lb	85	8	tested	test	VBN
cord-267897-w4pbq2lb	85	9	in	in	IN
cord-267897-w4pbq2lb	85	10	a	a	DT
cord-267897-w4pbq2lb	85	11	few	few	JJ
cord-267897-w4pbq2lb	85	12	DNA	dna	NN
cord-267897-w4pbq2lb	85	13	vaccine	vaccine	NN
cord-267897-w4pbq2lb	85	14	formulations	formulation	NNS
cord-267897-w4pbq2lb	85	15	.	.	.
cord-267897-w4pbq2lb	86	1	Here	here	RB
cord-267897-w4pbq2lb	86	2	it	-PRON-	PRP
cord-267897-w4pbq2lb	86	3	was	be	VBD
cord-267897-w4pbq2lb	86	4	shown	show	VBN
cord-267897-w4pbq2lb	86	5	42,43	42,43	CD
cord-267897-w4pbq2lb	86	6	that	that	DT
cord-267897-w4pbq2lb	86	7	aluminum	aluminum	NN
cord-267897-w4pbq2lb	86	8	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	86	9	had	have	VBD
cord-267897-w4pbq2lb	86	10	an	an	DT
cord-267897-w4pbq2lb	86	11	inhibiting	inhibit	VBG
cord-267897-w4pbq2lb	86	12	effect	effect	NN
cord-267897-w4pbq2lb	86	13	,	,	,
cord-267897-w4pbq2lb	86	14	whereas	whereas	IN
cord-267897-w4pbq2lb	86	15	aluminum	aluminum	NN
cord-267897-w4pbq2lb	86	16	phosphate	phosphate	NN
cord-267897-w4pbq2lb	86	17	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	86	18	augmented	augment	VBD
cord-267897-w4pbq2lb	86	19	the	the	DT
cord-267897-w4pbq2lb	86	20	immune	immune	JJ
cord-267897-w4pbq2lb	86	21	response	response	NN
cord-267897-w4pbq2lb	86	22	against	against	IN
cord-267897-w4pbq2lb	86	23	the	the	DT
cord-267897-w4pbq2lb	86	24	antigen	antigen	NN
cord-267897-w4pbq2lb	86	25	encoded	encode	VBN
cord-267897-w4pbq2lb	86	26	by	by	IN
cord-267897-w4pbq2lb	86	27	the	the	DT
cord-267897-w4pbq2lb	86	28	DNA	dna	NN
cord-267897-w4pbq2lb	86	29	nucleotide	nucleotide	NN
cord-267897-w4pbq2lb	86	30	.	.	.
cord-267897-w4pbq2lb	87	1	The	the	DT
cord-267897-w4pbq2lb	87	2	content	content	NN
cord-267897-w4pbq2lb	87	3	of	of	IN
cord-267897-w4pbq2lb	87	4	phosphate	phosphate	NN
cord-267897-w4pbq2lb	87	5	in	in	IN
cord-267897-w4pbq2lb	87	6	the	the	DT
cord-267897-w4pbq2lb	87	7	DNA	dna	NN
cord-267897-w4pbq2lb	87	8	molecule	molecule	NN
cord-267897-w4pbq2lb	87	9	apparently	apparently	RB
cord-267897-w4pbq2lb	87	10	gives	give	VBZ
cord-267897-w4pbq2lb	87	11	it	-PRON-	PRP
cord-267897-w4pbq2lb	87	12	a	a	DT
cord-267897-w4pbq2lb	87	13	high	high	JJ
cord-267897-w4pbq2lb	87	14	binding	bind	VBG
cord-267897-w4pbq2lb	87	15	affinity	affinity	NN
cord-267897-w4pbq2lb	87	16	to	to	IN
cord-267897-w4pbq2lb	87	17	the	the	DT
cord-267897-w4pbq2lb	87	18	aluminum	aluminum	NN
cord-267897-w4pbq2lb	87	19	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	87	20	,	,	,
cord-267897-w4pbq2lb	87	21	which	which	WDT
cord-267897-w4pbq2lb	87	22	in	in	IN
cord-267897-w4pbq2lb	87	23	turn	turn	NN
cord-267897-w4pbq2lb	87	24	prevents	prevent	VBZ
cord-267897-w4pbq2lb	87	25	efficient	efficient	JJ
cord-267897-w4pbq2lb	87	26	transcription	transcription	NN
cord-267897-w4pbq2lb	87	27	and	and	CC
cord-267897-w4pbq2lb	87	28	translation	translation	NN
cord-267897-w4pbq2lb	87	29	into	into	IN
cord-267897-w4pbq2lb	87	30	protein	protein	NN
cord-267897-w4pbq2lb	87	31	.	.	.
cord-267897-w4pbq2lb	88	1	43	43	CD
cord-267897-w4pbq2lb	88	2	 	 	_SP
cord-267897-w4pbq2lb	89	1	It	-PRON-	PRP
cord-267897-w4pbq2lb	89	2	has	have	VBZ
cord-267897-w4pbq2lb	89	3	recently	recently	RB
cord-267897-w4pbq2lb	89	4	been	be	VBN
cord-267897-w4pbq2lb	89	5	shown	show	VBN
cord-267897-w4pbq2lb	89	6	that	that	IN
cord-267897-w4pbq2lb	89	7	certain	certain	JJ
cord-267897-w4pbq2lb	89	8	metal	metal	NN
cord-267897-w4pbq2lb	89	9	ions	ion	NNS
cord-267897-w4pbq2lb	89	10	potentially	potentially	RB
cord-267897-w4pbq2lb	89	11	present	present	JJ
cord-267897-w4pbq2lb	89	12	in	in	IN
cord-267897-w4pbq2lb	89	13	mineral	mineral	NN
cord-267897-w4pbq2lb	89	14	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	89	15	formulations	formulation	NNS
cord-267897-w4pbq2lb	89	16	may	may	MD
cord-267897-w4pbq2lb	89	17	have	have	VB
cord-267897-w4pbq2lb	89	18	a	a	DT
cord-267897-w4pbq2lb	89	19	destabilizing	destabilizing	JJ
cord-267897-w4pbq2lb	89	20	effect	effect	NN
cord-267897-w4pbq2lb	89	21	on	on	IN
cord-267897-w4pbq2lb	89	22	vaccine	vaccine	NN
cord-267897-w4pbq2lb	89	23	stability	stability	NN
cord-267897-w4pbq2lb	89	24	.	.	.
cord-267897-w4pbq2lb	90	1	Schlegl	Schlegl	NNP
cord-267897-w4pbq2lb	90	2	et	et	NNP
cord-267897-w4pbq2lb	90	3	al	al	NNP
cord-267897-w4pbq2lb	90	4	.	.	.
cord-267897-w4pbq2lb	91	1	44	44	CD
cord-267897-w4pbq2lb	91	2	demonstrated	demonstrate	VBD
cord-267897-w4pbq2lb	91	3	that	that	IN
cord-267897-w4pbq2lb	91	4	high	high	JJ
cord-267897-w4pbq2lb	91	5	amounts	amount	NNS
cord-267897-w4pbq2lb	91	6	of	of	IN
cord-267897-w4pbq2lb	91	7	residual	residual	JJ
cord-267897-w4pbq2lb	91	8	Cu	Cu	NNP
cord-267897-w4pbq2lb	91	9	þþ	þþ	IN
cord-267897-w4pbq2lb	91	10	ions	ion	NNS
cord-267897-w4pbq2lb	91	11	could	could	MD
cord-267897-w4pbq2lb	91	12	interact	interact	VB
cord-267897-w4pbq2lb	91	13	with	with	IN
cord-267897-w4pbq2lb	91	14	sodium	sodium	NN
cord-267897-w4pbq2lb	91	15	metabisulfite	metabisulfite	NN
cord-267897-w4pbq2lb	91	16	,	,	,
cord-267897-w4pbq2lb	91	17	which	which	WDT
cord-267897-w4pbq2lb	91	18	is	be	VBZ
cord-267897-w4pbq2lb	91	19	added	add	VBN
cord-267897-w4pbq2lb	91	20	to	to	IN
cord-267897-w4pbq2lb	91	21	vaccine	vaccine	NN
cord-267897-w4pbq2lb	91	22	formulations	formulation	NNS
cord-267897-w4pbq2lb	91	23	to	to	TO
cord-267897-w4pbq2lb	91	24	neutralize	neutralize	VB
cord-267897-w4pbq2lb	91	25	formaldehyde	formaldehyde	NN
cord-267897-w4pbq2lb	91	26	,	,	,
cord-267897-w4pbq2lb	91	27	leading	lead	VBG
cord-267897-w4pbq2lb	91	28	to	to	IN
cord-267897-w4pbq2lb	91	29	the	the	DT
cord-267897-w4pbq2lb	91	30	formation	formation	NN
cord-267897-w4pbq2lb	91	31	of	of	IN
cord-267897-w4pbq2lb	91	32	free	free	JJ
cord-267897-w4pbq2lb	91	33	radicals	radical	NNS
cord-267897-w4pbq2lb	91	34	.	.	.
cord-267897-w4pbq2lb	92	1	These	these	DT
cord-267897-w4pbq2lb	92	2	would	would	MD
cord-267897-w4pbq2lb	92	3	in	in	IN
cord-267897-w4pbq2lb	92	4	turn	turn	NN
cord-267897-w4pbq2lb	92	5	react	react	VB
cord-267897-w4pbq2lb	92	6	with	with	IN
cord-267897-w4pbq2lb	92	7	antigen	antigen	NN
cord-267897-w4pbq2lb	92	8	integrity	integrity	NN
cord-267897-w4pbq2lb	92	9	resulting	result	VBG
cord-267897-w4pbq2lb	92	10	in	in	IN
cord-267897-w4pbq2lb	92	11	a	a	DT
cord-267897-w4pbq2lb	92	12	significantly	significantly	RB
cord-267897-w4pbq2lb	92	13	reduced	reduce	VBN
cord-267897-w4pbq2lb	92	14	shelf	shelf	NN
cord-267897-w4pbq2lb	92	15	life	life	NN
cord-267897-w4pbq2lb	92	16	of	of	IN
cord-267897-w4pbq2lb	92	17	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	92	18	,	,	,
cord-267897-w4pbq2lb	92	19	as	as	IN
cord-267897-w4pbq2lb	92	20	exemplified	exemplify	VBN
cord-267897-w4pbq2lb	92	21	by	by	IN
cord-267897-w4pbq2lb	92	22	a	a	DT
cord-267897-w4pbq2lb	92	23	commercial	commercial	JJ
cord-267897-w4pbq2lb	92	24	vaccine	vaccine	NN
cord-267897-w4pbq2lb	92	25	against	against	IN
cord-267897-w4pbq2lb	92	26	Japanese	japanese	JJ
cord-267897-w4pbq2lb	92	27	encephalitis	encephalitis	NN
cord-267897-w4pbq2lb	92	28	virus	virus	NN
cord-267897-w4pbq2lb	92	29	(	(	-LRB-
cord-267897-w4pbq2lb	92	30	IXIARO	IXIARO	NNP
cord-267897-w4pbq2lb	92	31	)	)	-RRB-
cord-267897-w4pbq2lb	92	32	.	.	.
cord-267897-w4pbq2lb	93	1	There	there	EX
cord-267897-w4pbq2lb	93	2	are	be	VBP
cord-267897-w4pbq2lb	93	3	limitations	limitation	NNS
cord-267897-w4pbq2lb	93	4	for	for	IN
cord-267897-w4pbq2lb	93	5	the	the	DT
cord-267897-w4pbq2lb	93	6	content	content	NN
cord-267897-w4pbq2lb	93	7	of	of	IN
cord-267897-w4pbq2lb	93	8	aluminum	aluminum	NN
cord-267897-w4pbq2lb	93	9	and	and	CC
cord-267897-w4pbq2lb	93	10	calcium	calcium	NN
cord-267897-w4pbq2lb	93	11	allowed	allow	VBN
cord-267897-w4pbq2lb	93	12	in	in	IN
cord-267897-w4pbq2lb	93	13	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	93	14	for	for	IN
cord-267897-w4pbq2lb	93	15	humans	human	NNS
cord-267897-w4pbq2lb	93	16	,	,	,
cord-267897-w4pbq2lb	93	17	when	when	WRB
cord-267897-w4pbq2lb	93	18	administered	administer	VBN
cord-267897-w4pbq2lb	93	19	as	as	IN
cord-267897-w4pbq2lb	93	20	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	93	21	.	.	.
cord-267897-w4pbq2lb	94	1	These	these	DT
cord-267897-w4pbq2lb	94	2	limits	limit	NNS
cord-267897-w4pbq2lb	94	3	are	be	VBP
cord-267897-w4pbq2lb	94	4	1.25	1.25	CD
cord-267897-w4pbq2lb	94	5	mg	mg	NN
cord-267897-w4pbq2lb	94	6	aluminum	aluminum	NN
cord-267897-w4pbq2lb	94	7	per	per	IN
cord-267897-w4pbq2lb	94	8	dose	dose	NN
cord-267897-w4pbq2lb	94	9	in	in	IN
cord-267897-w4pbq2lb	94	10	Europe	Europe	NNP
cord-267897-w4pbq2lb	94	11	,	,	,
cord-267897-w4pbq2lb	94	12	45	45	CD
cord-267897-w4pbq2lb	94	13	and	and	CC
cord-267897-w4pbq2lb	94	14	in	in	IN
cord-267897-w4pbq2lb	94	15	the	the	DT
cord-267897-w4pbq2lb	94	16	United	United	NNP
cord-267897-w4pbq2lb	94	17	States	States	NNP
cord-267897-w4pbq2lb	94	18	,	,	,
cord-267897-w4pbq2lb	94	19	the	the	DT
cord-267897-w4pbq2lb	94	20	limit	limit	NN
cord-267897-w4pbq2lb	94	21	is	be	VBZ
cord-267897-w4pbq2lb	94	22	0.85	0.85	CD
cord-267897-w4pbq2lb	94	23	mg	mg	NNP
cord-267897-w4pbq2lb	94	24	aluminum	aluminum	NN
cord-267897-w4pbq2lb	94	25	per	per	IN
cord-267897-w4pbq2lb	94	26	dose	dose	NN
cord-267897-w4pbq2lb	94	27	if	if	IN
cord-267897-w4pbq2lb	94	28	determined	determine	VBN
cord-267897-w4pbq2lb	94	29	by	by	IN
cord-267897-w4pbq2lb	94	30	assay	assay	NN
cord-267897-w4pbq2lb	94	31	,	,	,
cord-267897-w4pbq2lb	94	32	1.14	1.14	CD
cord-267897-w4pbq2lb	94	33	mg	mg	NN
cord-267897-w4pbq2lb	94	34	if	if	IN
cord-267897-w4pbq2lb	94	35	determined	determine	VBN
cord-267897-w4pbq2lb	94	36	by	by	IN
cord-267897-w4pbq2lb	94	37	calculation	calculation	NN
cord-267897-w4pbq2lb	94	38	,	,	,
cord-267897-w4pbq2lb	94	39	and	and	CC
cord-267897-w4pbq2lb	94	40	1.25	1.25	CD
cord-267897-w4pbq2lb	94	41	mg	mg	NN
cord-267897-w4pbq2lb	94	42	if	if	IN
cord-267897-w4pbq2lb	94	43	safety	safety	NN
cord-267897-w4pbq2lb	94	44	and	and	CC
cord-267897-w4pbq2lb	94	45	efficacy	efficacy	NN
cord-267897-w4pbq2lb	94	46	data	datum	NNS
cord-267897-w4pbq2lb	94	47	justify	justify	VBP
cord-267897-w4pbq2lb	94	48	it	-PRON-	PRP
cord-267897-w4pbq2lb	94	49	.	.	.
cord-267897-w4pbq2lb	95	1	46	46	CD
cord-267897-w4pbq2lb	96	1	In	in	IN
cord-267897-w4pbq2lb	96	2	Europe	Europe	NNP
cord-267897-w4pbq2lb	96	3	,	,	,
cord-267897-w4pbq2lb	96	4	the	the	DT
cord-267897-w4pbq2lb	96	5	maximum	maximum	NN
cord-267897-w4pbq2lb	96	6	allowed	allow	VBN
cord-267897-w4pbq2lb	96	7	amount	amount	NN
cord-267897-w4pbq2lb	96	8	of	of	IN
cord-267897-w4pbq2lb	96	9	calcium	calcium	NN
cord-267897-w4pbq2lb	96	10	delivered	deliver	VBN
cord-267897-w4pbq2lb	96	11	by	by	IN
cord-267897-w4pbq2lb	96	12	calcium	calcium	NN
cord-267897-w4pbq2lb	96	13	phosphateeadjuvanted	phosphateeadjuvante	VBN
cord-267897-w4pbq2lb	96	14	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	96	15	is	be	VBZ
cord-267897-w4pbq2lb	96	16	1.3	1.3	CD
cord-267897-w4pbq2lb	96	17	mg	mg	NN
cord-267897-w4pbq2lb	97	1	Ca	ca	UH
cord-267897-w4pbq2lb	97	2	.	.	.
cord-267897-w4pbq2lb	98	1	There	there	EX
cord-267897-w4pbq2lb	98	2	is	be	VBZ
cord-267897-w4pbq2lb	98	3	,	,	,
cord-267897-w4pbq2lb	98	4	however	however	RB
cord-267897-w4pbq2lb	98	5	,	,	,
cord-267897-w4pbq2lb	98	6	no	no	DT
cord-267897-w4pbq2lb	98	7	obvious	obvious	JJ
cord-267897-w4pbq2lb	98	8	toxicological	toxicological	JJ
cord-267897-w4pbq2lb	98	9	rationale	rationale	NN
cord-267897-w4pbq2lb	98	10	behind	behind	IN
cord-267897-w4pbq2lb	98	11	limiting	limit	VBG
cord-267897-w4pbq2lb	98	12	the	the	DT
cord-267897-w4pbq2lb	98	13	amount	amount	NN
cord-267897-w4pbq2lb	98	14	of	of	IN
cord-267897-w4pbq2lb	98	15	calcium	calcium	NN
cord-267897-w4pbq2lb	98	16	in	in	IN
cord-267897-w4pbq2lb	98	17	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	98	18	to	to	IN
cord-267897-w4pbq2lb	98	19	1.3	1.3	CD
cord-267897-w4pbq2lb	98	20	mg	mg	NN
cord-267897-w4pbq2lb	98	21	/	/	SYM
cord-267897-w4pbq2lb	98	22	dose	dose	NN
cord-267897-w4pbq2lb	98	23	.	.	.
cord-267897-w4pbq2lb	99	1	Calcium	calcium	NN
cord-267897-w4pbq2lb	99	2	phosphate	phosphate	NN
cord-267897-w4pbq2lb	99	3	is	be	VBZ
cord-267897-w4pbq2lb	99	4	a	a	DT
cord-267897-w4pbq2lb	99	5	natural	natural	JJ
cord-267897-w4pbq2lb	99	6	constituent	constituent	NN
cord-267897-w4pbq2lb	99	7	of	of	IN
cord-267897-w4pbq2lb	99	8	mammals	mammal	NNS
cord-267897-w4pbq2lb	99	9	,	,	,
cord-267897-w4pbq2lb	99	10	and	and	CC
cord-267897-w4pbq2lb	99	11	it	-PRON-	PRP
cord-267897-w4pbq2lb	99	12	is	be	VBZ
cord-267897-w4pbq2lb	99	13	a	a	DT
cord-267897-w4pbq2lb	99	14	component	component	NN
cord-267897-w4pbq2lb	99	15	of	of	IN
cord-267897-w4pbq2lb	99	16	bone	bone	NN
cord-267897-w4pbq2lb	99	17	replacement	replacement	NN
cord-267897-w4pbq2lb	99	18	transplants	transplant	NNS
cord-267897-w4pbq2lb	99	19	in	in	IN
cord-267897-w4pbq2lb	99	20	much	much	RB
cord-267897-w4pbq2lb	99	21	higher	high	JJR
cord-267897-w4pbq2lb	99	22	amounts	amount	NNS
cord-267897-w4pbq2lb	99	23	with	with	IN
cord-267897-w4pbq2lb	99	24	no	no	DT
cord-267897-w4pbq2lb	99	25	toxicological	toxicological	JJ
cord-267897-w4pbq2lb	99	26	problems	problem	NNS
cord-267897-w4pbq2lb	99	27	.	.	.
cord-267897-w4pbq2lb	100	1	47	47	CD
cord-267897-w4pbq2lb	101	1	The	the	DT
cord-267897-w4pbq2lb	101	2	optimum	optimum	JJ
cord-267897-w4pbq2lb	101	3	dose	dose	NN
cord-267897-w4pbq2lb	101	4	of	of	IN
cord-267897-w4pbq2lb	101	5	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	101	6	is	be	VBZ
cord-267897-w4pbq2lb	101	7	normally	normally	RB
cord-267897-w4pbq2lb	101	8	determined	determine	VBN
cord-267897-w4pbq2lb	101	9	empirically	empirically	RB
cord-267897-w4pbq2lb	101	10	in	in	IN
cord-267897-w4pbq2lb	101	11	a	a	DT
cord-267897-w4pbq2lb	101	12	pilot	pilot	NN
cord-267897-w4pbq2lb	101	13	trial	trial	NN
cord-267897-w4pbq2lb	101	14	,	,	,
cord-267897-w4pbq2lb	101	15	but	but	CC
cord-267897-w4pbq2lb	101	16	helpful	helpful	JJ
cord-267897-w4pbq2lb	101	17	guidelines	guideline	NNS
cord-267897-w4pbq2lb	101	18	are	be	VBP
cord-267897-w4pbq2lb	101	19	available	available	JJ
cord-267897-w4pbq2lb	101	20	in	in	IN
cord-267897-w4pbq2lb	101	21	the	the	DT
cord-267897-w4pbq2lb	101	22	literature	literature	NN
cord-267897-w4pbq2lb	101	23	.	.	.
cord-267897-w4pbq2lb	102	1	In	in	IN
cord-267897-w4pbq2lb	102	2	veterinary	veterinary	JJ
cord-267897-w4pbq2lb	102	3	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	102	4	,	,	,
cord-267897-w4pbq2lb	102	5	there	there	EX
cord-267897-w4pbq2lb	102	6	is	be	VBZ
cord-267897-w4pbq2lb	102	7	no	no	DT
cord-267897-w4pbq2lb	102	8	defined	define	VBN
cord-267897-w4pbq2lb	102	9	maximum	maximum	JJ
cord-267897-w4pbq2lb	102	10	limit	limit	NN
cord-267897-w4pbq2lb	102	11	for	for	IN
cord-267897-w4pbq2lb	102	12	the	the	DT
cord-267897-w4pbq2lb	102	13	allowed	allow	VBN
cord-267897-w4pbq2lb	102	14	content	content	NN
cord-267897-w4pbq2lb	102	15	of	of	IN
cord-267897-w4pbq2lb	102	16	aluminum	aluminum	NN
cord-267897-w4pbq2lb	102	17	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	102	18	.	.	.
cord-267897-w4pbq2lb	103	1	Here	here	RB
cord-267897-w4pbq2lb	103	2	the	the	DT
cord-267897-w4pbq2lb	103	3	dose	dose	NN
cord-267897-w4pbq2lb	103	4	is	be	VBZ
cord-267897-w4pbq2lb	103	5	normally	normally	RB
cord-267897-w4pbq2lb	103	6	set	set	VBN
cord-267897-w4pbq2lb	103	7	from	from	IN
cord-267897-w4pbq2lb	103	8	a	a	DT
cord-267897-w4pbq2lb	103	9	balance	balance	NN
cord-267897-w4pbq2lb	103	10	between	between	IN
cord-267897-w4pbq2lb	103	11	efficacy	efficacy	NN
cord-267897-w4pbq2lb	103	12	and	and	CC
cord-267897-w4pbq2lb	103	13	local	local	JJ
cord-267897-w4pbq2lb	103	14	reactogenicity	reactogenicity	NN
cord-267897-w4pbq2lb	103	15	.	.	.
cord-267897-w4pbq2lb	104	1	For	for	IN
cord-267897-w4pbq2lb	104	2	doseeresponse	doseeresponse	NN
cord-267897-w4pbq2lb	104	3	relations	relation	NNS
cord-267897-w4pbq2lb	104	4	of	of	IN
cord-267897-w4pbq2lb	104	5	both	both	DT
cord-267897-w4pbq2lb	104	6	types	type	NNS
cord-267897-w4pbq2lb	104	7	of	of	IN
cord-267897-w4pbq2lb	104	8	mineral	mineral	NN
cord-267897-w4pbq2lb	104	9	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	104	10	in	in	IN
cord-267897-w4pbq2lb	104	11	combination	combination	NN
cord-267897-w4pbq2lb	104	12	with	with	IN
cord-267897-w4pbq2lb	104	13	bacterial	bacterial	JJ
cord-267897-w4pbq2lb	104	14	antigens	antigen	NNS
cord-267897-w4pbq2lb	104	15	the	the	DT
cord-267897-w4pbq2lb	104	16	immunomodulation	immunomodulation	NN
cord-267897-w4pbq2lb	104	17	observed	observe	VBN
cord-267897-w4pbq2lb	104	18	may	may	MD
cord-267897-w4pbq2lb	104	19	reflect	reflect	VB
cord-267897-w4pbq2lb	104	20	a	a	DT
cord-267897-w4pbq2lb	104	21	composite	composite	JJ
cord-267897-w4pbq2lb	104	22	effect	effect	NN
cord-267897-w4pbq2lb	104	23	between	between	IN
cord-267897-w4pbq2lb	104	24	the	the	DT
cord-267897-w4pbq2lb	104	25	mineral	mineral	NN
cord-267897-w4pbq2lb	104	26	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	104	27	itself	-PRON-	PRP
cord-267897-w4pbq2lb	104	28	and	and	CC
cord-267897-w4pbq2lb	104	29	the	the	DT
cord-267897-w4pbq2lb	104	30	immunomodulatory	immunomodulatory	JJ
cord-267897-w4pbq2lb	104	31	and	and	CC
cord-267897-w4pbq2lb	104	32	adjuvantactive	adjuvantactive	JJ
cord-267897-w4pbq2lb	104	33	bacterial	bacterial	JJ
cord-267897-w4pbq2lb	104	34	substances	substance	NNS
cord-267897-w4pbq2lb	104	35	,	,	,
cord-267897-w4pbq2lb	104	36	known	know	VBN
cord-267897-w4pbq2lb	104	37	as	as	IN
cord-267897-w4pbq2lb	104	38	pathogen	pathogen	NN
cord-267897-w4pbq2lb	104	39	-	-	HYPH
cord-267897-w4pbq2lb	104	40	associated	associate	VBN
cord-267897-w4pbq2lb	104	41	molecular	molecular	JJ
cord-267897-w4pbq2lb	104	42	patterns	pattern	NNS
cord-267897-w4pbq2lb	104	43	(	(	-LRB-
cord-267897-w4pbq2lb	104	44	PAMPs	pamp	NNS
cord-267897-w4pbq2lb	104	45	)	)	-RRB-
cord-267897-w4pbq2lb	104	46	or	or	CC
cord-267897-w4pbq2lb	104	47	Toll	toll	NN
cord-267897-w4pbq2lb	104	48	-	-	HYPH
cord-267897-w4pbq2lb	104	49	like	like	JJ
cord-267897-w4pbq2lb	104	50	receptor	receptor	NN
cord-267897-w4pbq2lb	104	51	(	(	-LRB-
cord-267897-w4pbq2lb	104	52	TLR	TLR	NNP
cord-267897-w4pbq2lb	104	53	)	)	-RRB-
cord-267897-w4pbq2lb	104	54	agonists	agonist	NNS
cord-267897-w4pbq2lb	104	55	such	such	JJ
cord-267897-w4pbq2lb	104	56	as	as	IN
cord-267897-w4pbq2lb	104	57	muramyl	muramyl	NNP
cord-267897-w4pbq2lb	104	58	peptides	peptide	NNS
cord-267897-w4pbq2lb	104	59	from	from	IN
cord-267897-w4pbq2lb	104	60	peptidoglycans	peptidoglycans	NNP
cord-267897-w4pbq2lb	104	61	,	,	,
cord-267897-w4pbq2lb	104	62	lipopolysaccharides	lipopolysaccharides	NNP
cord-267897-w4pbq2lb	104	63	(	(	-LRB-
cord-267897-w4pbq2lb	104	64	LPS	LPS	NNP
cord-267897-w4pbq2lb	104	65	)	)	-RRB-
cord-267897-w4pbq2lb	104	66	,	,	,
cord-267897-w4pbq2lb	104	67	trehalose	trehalose	DT
cord-267897-w4pbq2lb	104	68	dimycolate	dimycolate	NN
cord-267897-w4pbq2lb	104	69	(	(	-LRB-
cord-267897-w4pbq2lb	104	70	"	"	``
cord-267897-w4pbq2lb	104	71	cord	cord	NN
cord-267897-w4pbq2lb	104	72	factor	factor	NN
cord-267897-w4pbq2lb	104	73	"	"	''
cord-267897-w4pbq2lb	104	74	)	)	-RRB-
cord-267897-w4pbq2lb	104	75	,	,	,
cord-267897-w4pbq2lb	104	76	or	or	CC
cord-267897-w4pbq2lb	104	77	CpG	cpg	NN
cord-267897-w4pbq2lb	104	78	motifs	motif	NNS
cord-267897-w4pbq2lb	104	79	from	from	IN
cord-267897-w4pbq2lb	104	80	bacterial	bacterial	JJ
cord-267897-w4pbq2lb	104	81	DNA	dna	NN
cord-267897-w4pbq2lb	104	82	.	.	.
cord-267897-w4pbq2lb	105	1	48	48	CD
cord-267897-w4pbq2lb	105	2	 	 	_SP
cord-267897-w4pbq2lb	106	1	The	the	DT
cord-267897-w4pbq2lb	106	2	immunostimulating	immunostimulate	VBG
cord-267897-w4pbq2lb	106	3	effect	effect	NN
cord-267897-w4pbq2lb	106	4	of	of	IN
cord-267897-w4pbq2lb	106	5	the	the	DT
cord-267897-w4pbq2lb	106	6	traditional	traditional	JJ
cord-267897-w4pbq2lb	106	7	aluminum	aluminum	NN
cord-267897-w4pbq2lb	106	8	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	106	9	is	be	VBZ
cord-267897-w4pbq2lb	106	10	highly	highly	RB
cord-267897-w4pbq2lb	106	11	complex	complex	JJ
cord-267897-w4pbq2lb	106	12	and	and	CC
cord-267897-w4pbq2lb	106	13	must	must	MD
cord-267897-w4pbq2lb	106	14	be	be	VB
cord-267897-w4pbq2lb	106	15	attributed	attribute	VBN
cord-267897-w4pbq2lb	106	16	to	to	IN
cord-267897-w4pbq2lb	106	17	several	several	JJ
cord-267897-w4pbq2lb	106	18	different	different	JJ
cord-267897-w4pbq2lb	106	19	mechanisms	mechanism	NNS
cord-267897-w4pbq2lb	106	20	.	.	.
cord-267897-w4pbq2lb	107	1	In	in	IN
cord-267897-w4pbq2lb	107	2	the	the	DT
cord-267897-w4pbq2lb	107	3	older	old	JJR
cord-267897-w4pbq2lb	107	4	literature	literature	NN
cord-267897-w4pbq2lb	107	5	,	,	,
cord-267897-w4pbq2lb	107	6	4	4	CD
cord-267897-w4pbq2lb	107	7	the	the	DT
cord-267897-w4pbq2lb	107	8	function	function	NN
cord-267897-w4pbq2lb	107	9	of	of	IN
cord-267897-w4pbq2lb	107	10	a	a	DT
cord-267897-w4pbq2lb	107	11	repository	repository	NN
cord-267897-w4pbq2lb	107	12	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	107	13	was	be	VBD
cord-267897-w4pbq2lb	107	14	originally	originally	RB
cord-267897-w4pbq2lb	107	15	described	describe	VBN
cord-267897-w4pbq2lb	107	16	as	as	IN
cord-267897-w4pbq2lb	107	17	to	to	TO
cord-267897-w4pbq2lb	107	18	delay	delay	VB
cord-267897-w4pbq2lb	107	19	clearing	clearing	NN
cord-267897-w4pbq2lb	107	20	from	from	IN
cord-267897-w4pbq2lb	107	21	the	the	DT
cord-267897-w4pbq2lb	107	22	injection	injection	NN
cord-267897-w4pbq2lb	107	23	site	site	NN
cord-267897-w4pbq2lb	107	24	and	and	CC
cord-267897-w4pbq2lb	107	25	sustain	sustain	VB
cord-267897-w4pbq2lb	107	26	a	a	DT
cord-267897-w4pbq2lb	107	27	gradual	gradual	JJ
cord-267897-w4pbq2lb	107	28	release	release	NN
cord-267897-w4pbq2lb	107	29	of	of	IN
cord-267897-w4pbq2lb	107	30	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	107	31	antigen	antigen	NN
cord-267897-w4pbq2lb	107	32	from	from	IN
cord-267897-w4pbq2lb	107	33	the	the	DT
cord-267897-w4pbq2lb	107	34	inoculated	inoculate	VBN
cord-267897-w4pbq2lb	107	35	depot	depot	NN
cord-267897-w4pbq2lb	107	36	.	.	.
cord-267897-w4pbq2lb	108	1	Although	although	IN
cord-267897-w4pbq2lb	108	2	gradual	gradual	JJ
cord-267897-w4pbq2lb	108	3	release	release	NN
cord-267897-w4pbq2lb	108	4	and	and	CC
cord-267897-w4pbq2lb	108	5	delayed	delay	VBN
cord-267897-w4pbq2lb	108	6	clearing	clearing	NN
cord-267897-w4pbq2lb	108	7	may	may	MD
cord-267897-w4pbq2lb	108	8	indeed	indeed	RB
cord-267897-w4pbq2lb	108	9	play	play	VB
cord-267897-w4pbq2lb	108	10	a	a	DT
cord-267897-w4pbq2lb	108	11	role	role	NN
cord-267897-w4pbq2lb	108	12	,	,	,
cord-267897-w4pbq2lb	108	13	it	-PRON-	PRP
cord-267897-w4pbq2lb	108	14	quickly	quickly	RB
cord-267897-w4pbq2lb	108	15	became	become	VBD
cord-267897-w4pbq2lb	108	16	obvious	obvious	JJ
cord-267897-w4pbq2lb	108	17	that	that	IN
cord-267897-w4pbq2lb	108	18	the	the	DT
cord-267897-w4pbq2lb	108	19	gradual	gradual	JJ
cord-267897-w4pbq2lb	108	20	release	release	NN
cord-267897-w4pbq2lb	108	21	was	be	VBD
cord-267897-w4pbq2lb	108	22	insufficient	insufficient	JJ
cord-267897-w4pbq2lb	108	23	in	in	IN
cord-267897-w4pbq2lb	108	24	explaining	explain	VBG
cord-267897-w4pbq2lb	108	25	the	the	DT
cord-267897-w4pbq2lb	108	26	mechanisms	mechanism	NNS
cord-267897-w4pbq2lb	108	27	of	of	IN
cord-267897-w4pbq2lb	108	28	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	108	29	activity	activity	NN
cord-267897-w4pbq2lb	108	30	.	.	.
cord-267897-w4pbq2lb	109	1	However	however	RB
cord-267897-w4pbq2lb	109	2	,	,	,
cord-267897-w4pbq2lb	109	3	the	the	DT
cord-267897-w4pbq2lb	109	4	physical	physical	JJ
cord-267897-w4pbq2lb	109	5	adsorption	adsorption	NN
cord-267897-w4pbq2lb	109	6	characteristics	characteristic	NNS
cord-267897-w4pbq2lb	109	7	of	of	IN
cord-267897-w4pbq2lb	109	8	antigen	antigen	NN
cord-267897-w4pbq2lb	109	9	onto	onto	IN
cord-267897-w4pbq2lb	109	10	the	the	DT
cord-267897-w4pbq2lb	109	11	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	109	12	is	be	VBZ
cord-267897-w4pbq2lb	109	13	still	still	RB
cord-267897-w4pbq2lb	109	14	considered	consider	VBN
cord-267897-w4pbq2lb	109	15	to	to	TO
cord-267897-w4pbq2lb	109	16	be	be	VB
cord-267897-w4pbq2lb	109	17	a	a	DT
cord-267897-w4pbq2lb	109	18	very	very	RB
cord-267897-w4pbq2lb	109	19	important	important	JJ
cord-267897-w4pbq2lb	109	20	mechanism	mechanism	NN
cord-267897-w4pbq2lb	109	21	for	for	IN
cord-267897-w4pbq2lb	109	22	the	the	DT
cord-267897-w4pbq2lb	109	23	function	function	NN
cord-267897-w4pbq2lb	109	24	of	of	IN
cord-267897-w4pbq2lb	109	25	mineral	mineral	NN
cord-267897-w4pbq2lb	109	26	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	109	27	.	.	.
cord-267897-w4pbq2lb	110	1	The	the	DT
cord-267897-w4pbq2lb	110	2	literature	literature	NN
cord-267897-w4pbq2lb	110	3	holds	hold	VBZ
cord-267897-w4pbq2lb	110	4	examples	example	NNS
cord-267897-w4pbq2lb	110	5	of	of	IN
cord-267897-w4pbq2lb	110	6	publications	publication	NNS
cord-267897-w4pbq2lb	110	7	in	in	IN
cord-267897-w4pbq2lb	110	8	which	which	WDT
cord-267897-w4pbq2lb	110	9	injection	injection	NN
cord-267897-w4pbq2lb	110	10	of	of	IN
cord-267897-w4pbq2lb	110	11	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	110	12	and	and	CC
cord-267897-w4pbq2lb	110	13	unadsorbed	unadsorbed	JJ
cord-267897-w4pbq2lb	110	14	antigen	antigen	NN
cord-267897-w4pbq2lb	110	15	at	at	IN
cord-267897-w4pbq2lb	110	16	distant	distant	JJ
cord-267897-w4pbq2lb	110	17	sites	site	NNS
cord-267897-w4pbq2lb	110	18	have	have	VBP
cord-267897-w4pbq2lb	110	19	led	lead	VBN
cord-267897-w4pbq2lb	110	20	to	to	IN
cord-267897-w4pbq2lb	110	21	immunostimulation	immunostimulation	NN
cord-267897-w4pbq2lb	110	22	toward	toward	IN
cord-267897-w4pbq2lb	110	23	the	the	DT
cord-267897-w4pbq2lb	110	24	antigen	antigen	NN
cord-267897-w4pbq2lb	110	25	49	49	CD
cord-267897-w4pbq2lb	110	26	;	;	:
cord-267897-w4pbq2lb	110	27	however	however	RB
cord-267897-w4pbq2lb	110	28	,	,	,
cord-267897-w4pbq2lb	110	29	this	this	DT
cord-267897-w4pbq2lb	110	30	is	be	VBZ
cord-267897-w4pbq2lb	110	31	not	not	RB
cord-267897-w4pbq2lb	110	32	the	the	DT
cord-267897-w4pbq2lb	110	33	consistent	consistent	JJ
cord-267897-w4pbq2lb	110	34	picture	picture	NN
cord-267897-w4pbq2lb	110	35	,	,	,
cord-267897-w4pbq2lb	110	36	50	50	CD
cord-267897-w4pbq2lb	110	37	and	and	CC
cord-267897-w4pbq2lb	110	38	the	the	DT
cord-267897-w4pbq2lb	110	39	nature	nature	NN
cord-267897-w4pbq2lb	110	40	of	of	IN
cord-267897-w4pbq2lb	110	41	the	the	DT
cord-267897-w4pbq2lb	110	42	antigen	antigen	NN
cord-267897-w4pbq2lb	110	43	chosen	choose	VBN
cord-267897-w4pbq2lb	110	44	for	for	IN
cord-267897-w4pbq2lb	110	45	the	the	DT
cord-267897-w4pbq2lb	110	46	work	work	NN
cord-267897-w4pbq2lb	110	47	may	may	MD
cord-267897-w4pbq2lb	110	48	provide	provide	VB
cord-267897-w4pbq2lb	110	49	part	part	NN
cord-267897-w4pbq2lb	110	50	of	of	IN
cord-267897-w4pbq2lb	110	51	the	the	DT
cord-267897-w4pbq2lb	110	52	explanation	explanation	NN
cord-267897-w4pbq2lb	110	53	for	for	IN
cord-267897-w4pbq2lb	110	54	deviating	deviate	VBG
cord-267897-w4pbq2lb	110	55	conclusions	conclusion	NNS
cord-267897-w4pbq2lb	110	56	.	.	.
cord-267897-w4pbq2lb	111	1	As	as	IN
cord-267897-w4pbq2lb	111	2	a	a	DT
cord-267897-w4pbq2lb	111	3	general	general	JJ
cord-267897-w4pbq2lb	111	4	rule	rule	NN
cord-267897-w4pbq2lb	111	5	,	,	,
cord-267897-w4pbq2lb	111	6	the	the	DT
cord-267897-w4pbq2lb	111	7	antigen	antigen	NN
cord-267897-w4pbq2lb	111	8	should	should	MD
cord-267897-w4pbq2lb	111	9	be	be	VB
cord-267897-w4pbq2lb	111	10	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	111	11	onto	onto	IN
cord-267897-w4pbq2lb	111	12	the	the	DT
cord-267897-w4pbq2lb	111	13	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	111	14	prior	prior	RB
cord-267897-w4pbq2lb	111	15	to	to	IN
cord-267897-w4pbq2lb	111	16	immunization	immunization	NN
cord-267897-w4pbq2lb	111	17	and	and	CC
cord-267897-w4pbq2lb	111	18	the	the	DT
cord-267897-w4pbq2lb	111	19	adsorption	adsorption	NN
cord-267897-w4pbq2lb	111	20	should	should	MD
cord-267897-w4pbq2lb	111	21	be	be	VB
cord-267897-w4pbq2lb	111	22	carefully	carefully	RB
cord-267897-w4pbq2lb	111	23	monitored	monitor	VBN
cord-267897-w4pbq2lb	111	24	.	.	.
cord-267897-w4pbq2lb	112	1	A	a	DT
cord-267897-w4pbq2lb	112	2	consequence	consequence	NN
cord-267897-w4pbq2lb	112	3	of	of	IN
cord-267897-w4pbq2lb	112	4	the	the	DT
cord-267897-w4pbq2lb	112	5	physical	physical	JJ
cord-267897-w4pbq2lb	112	6	attachment	attachment	NN
cord-267897-w4pbq2lb	112	7	of	of	IN
cord-267897-w4pbq2lb	112	8	the	the	DT
cord-267897-w4pbq2lb	112	9	antigen	antigen	NN
cord-267897-w4pbq2lb	112	10	onto	onto	IN
cord-267897-w4pbq2lb	112	11	the	the	DT
cord-267897-w4pbq2lb	112	12	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	112	13	is	be	VBZ
cord-267897-w4pbq2lb	112	14	,	,	,
cord-267897-w4pbq2lb	112	15	that	that	IN
cord-267897-w4pbq2lb	112	16	a	a	DT
cord-267897-w4pbq2lb	112	17	soluble	soluble	JJ
cord-267897-w4pbq2lb	112	18	antigen	antigen	NN
cord-267897-w4pbq2lb	112	19	upon	upon	IN
cord-267897-w4pbq2lb	112	20	adsorption	adsorption	NN
cord-267897-w4pbq2lb	112	21	may	may	MD
cord-267897-w4pbq2lb	112	22	be	be	VB
cord-267897-w4pbq2lb	112	23	presented	present	VBN
cord-267897-w4pbq2lb	112	24	to	to	IN
cord-267897-w4pbq2lb	112	25	the	the	DT
cord-267897-w4pbq2lb	112	26	immunocompetent	immunocompetent	JJ
cord-267897-w4pbq2lb	112	27	cells	cell	NNS
cord-267897-w4pbq2lb	112	28	in	in	IN
cord-267897-w4pbq2lb	112	29	a	a	DT
cord-267897-w4pbq2lb	112	30	"	"	``
cord-267897-w4pbq2lb	112	31	particulate	particulate	NN
cord-267897-w4pbq2lb	112	32	"	"	''
cord-267897-w4pbq2lb	112	33	manner	manner	NN
cord-267897-w4pbq2lb	112	34	,	,	,
cord-267897-w4pbq2lb	112	35	which	which	WDT
cord-267897-w4pbq2lb	112	36	could	could	MD
cord-267897-w4pbq2lb	112	37	facilitate	facilitate	VB
cord-267897-w4pbq2lb	112	38	antigen	antigen	NN
cord-267897-w4pbq2lb	112	39	targeting	targeting	NN
cord-267897-w4pbq2lb	112	40	,	,	,
cord-267897-w4pbq2lb	112	41	i.e.	i.e.	FW
cord-267897-w4pbq2lb	112	42	,	,	,
cord-267897-w4pbq2lb	112	43	favor	favor	VBP
cord-267897-w4pbq2lb	112	44	uptake	uptake	NN
cord-267897-w4pbq2lb	112	45	by	by	IN
cord-267897-w4pbq2lb	112	46	antigen	antigen	NN
cord-267897-w4pbq2lb	112	47	-	-	HYPH
cord-267897-w4pbq2lb	112	48	presenting	present	VBG
cord-267897-w4pbq2lb	112	49	cells	cell	NNS
cord-267897-w4pbq2lb	112	50	(	(	-LRB-
cord-267897-w4pbq2lb	112	51	APCs	apc	NNS
cord-267897-w4pbq2lb	112	52	)	)	-RRB-
cord-267897-w4pbq2lb	112	53	.	.	.
cord-267897-w4pbq2lb	113	1	A	a	DT
cord-267897-w4pbq2lb	113	2	likely	likely	JJ
cord-267897-w4pbq2lb	113	3	explanation	explanation	NN
cord-267897-w4pbq2lb	113	4	is	be	VBZ
cord-267897-w4pbq2lb	113	5	that	that	IN
cord-267897-w4pbq2lb	113	6	APCs	apc	NNS
cord-267897-w4pbq2lb	113	7	may	may	MD
cord-267897-w4pbq2lb	113	8	be	be	VB
cord-267897-w4pbq2lb	113	9	more	more	RBR
cord-267897-w4pbq2lb	113	10	efficient	efficient	JJ
cord-267897-w4pbq2lb	113	11	in	in	IN
cord-267897-w4pbq2lb	113	12	antigen	antigen	NN
cord-267897-w4pbq2lb	113	13	uptake	uptake	NN
cord-267897-w4pbq2lb	113	14	by	by	IN
cord-267897-w4pbq2lb	113	15	phagocytosis	phagocytosis	NN
cord-267897-w4pbq2lb	113	16	than	than	IN
cord-267897-w4pbq2lb	113	17	by	by	IN
cord-267897-w4pbq2lb	113	18	pinocytosis	pinocytosis	NNP
cord-267897-w4pbq2lb	113	19	.	.	.
cord-267897-w4pbq2lb	114	1	Mannhalter	Mannhalter	NNP
cord-267897-w4pbq2lb	114	2	and	and	CC
cord-267897-w4pbq2lb	114	3	coworkers	coworker	NNS
cord-267897-w4pbq2lb	114	4	convincingly	convincingly	RB
cord-267897-w4pbq2lb	114	5	demonstrated	demonstrate	VBD
cord-267897-w4pbq2lb	114	6	enhanced	enhanced	JJ
cord-267897-w4pbq2lb	114	7	uptake	uptake	NN
cord-267897-w4pbq2lb	114	8	as	as	RB
cord-267897-w4pbq2lb	114	9	well	well	RB
cord-267897-w4pbq2lb	114	10	as	as	IN
cord-267897-w4pbq2lb	114	11	antigen	antigen	NN
cord-267897-w4pbq2lb	114	12	presentation	presentation	NN
cord-267897-w4pbq2lb	114	13	as	as	IN
cord-267897-w4pbq2lb	114	14	measured	measure	VBN
cord-267897-w4pbq2lb	114	15	by	by	IN
cord-267897-w4pbq2lb	114	16	T	t	NN
cord-267897-w4pbq2lb	114	17	-	-	HYPH
cord-267897-w4pbq2lb	114	18	cell	cell	NN
cord-267897-w4pbq2lb	114	19	proliferation	proliferation	NN
cord-267897-w4pbq2lb	114	20	of	of	IN
cord-267897-w4pbq2lb	114	21	aluminum	aluminum	NN
cord-267897-w4pbq2lb	114	22	-	-	HYPH
cord-267897-w4pbq2lb	114	23	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	114	24	tetanus	tetanus	NN
cord-267897-w4pbq2lb	114	25	toxoid	toxoid	NN
cord-267897-w4pbq2lb	114	26	compared	compare	VBN
cord-267897-w4pbq2lb	114	27	with	with	IN
cord-267897-w4pbq2lb	114	28	the	the	DT
cord-267897-w4pbq2lb	114	29	soluble	soluble	JJ
cord-267897-w4pbq2lb	114	30	toxoid	toxoid	NN
cord-267897-w4pbq2lb	114	31	,	,	,
cord-267897-w4pbq2lb	114	32	by	by	IN
cord-267897-w4pbq2lb	114	33	human	human	JJ
cord-267897-w4pbq2lb	114	34	APCs	apc	NNS
cord-267897-w4pbq2lb	114	35	in	in	IN
cord-267897-w4pbq2lb	114	36	vitro	vitro	FW
cord-267897-w4pbq2lb	114	37	.	.	.
cord-267897-w4pbq2lb	115	1	51	51	CD
cord-267897-w4pbq2lb	116	1	The	the	DT
cord-267897-w4pbq2lb	116	2	physicochemical	physicochemical	JJ
cord-267897-w4pbq2lb	116	3	mechanisms	mechanism	NNS
cord-267897-w4pbq2lb	116	4	behind	behind	IN
cord-267897-w4pbq2lb	116	5	the	the	DT
cord-267897-w4pbq2lb	116	6	antigen	antigen	NN
cord-267897-w4pbq2lb	116	7	adsorption	adsorption	NN
cord-267897-w4pbq2lb	116	8	itself	-PRON-	PRP
cord-267897-w4pbq2lb	116	9	is	be	VBZ
cord-267897-w4pbq2lb	116	10	complex	complex	JJ
cord-267897-w4pbq2lb	116	11	,	,	,
cord-267897-w4pbq2lb	116	12	and	and	CC
cord-267897-w4pbq2lb	116	13	,	,	,
cord-267897-w4pbq2lb	116	14	depending	depend	VBG
cord-267897-w4pbq2lb	116	15	upon	upon	IN
cord-267897-w4pbq2lb	116	16	the	the	DT
cord-267897-w4pbq2lb	116	17	nature	nature	NN
cord-267897-w4pbq2lb	116	18	of	of	IN
cord-267897-w4pbq2lb	116	19	the	the	DT
cord-267897-w4pbq2lb	116	20	individual	individual	JJ
cord-267897-w4pbq2lb	116	21	antigen	antigen	NN
cord-267897-w4pbq2lb	116	22	and	and	CC
cord-267897-w4pbq2lb	116	23	the	the	DT
cord-267897-w4pbq2lb	116	24	characteristics	characteristic	NNS
cord-267897-w4pbq2lb	116	25	of	of	IN
cord-267897-w4pbq2lb	116	26	the	the	DT
cord-267897-w4pbq2lb	116	27	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	116	28	particles	particle	NNS
cord-267897-w4pbq2lb	116	29	,	,	,
cord-267897-w4pbq2lb	116	30	some	some	DT
cord-267897-w4pbq2lb	116	31	mechanisms	mechanism	NNS
cord-267897-w4pbq2lb	116	32	may	may	MD
cord-267897-w4pbq2lb	116	33	predominate	predominate	VB
cord-267897-w4pbq2lb	116	34	over	over	IN
cord-267897-w4pbq2lb	116	35	others	other	NNS
cord-267897-w4pbq2lb	116	36	.	.	.
cord-267897-w4pbq2lb	117	1	The	the	DT
cord-267897-w4pbq2lb	117	2	primary	primary	JJ
cord-267897-w4pbq2lb	117	3	mechanisms	mechanism	NNS
cord-267897-w4pbq2lb	117	4	responsible	responsible	JJ
cord-267897-w4pbq2lb	117	5	for	for	IN
cord-267897-w4pbq2lb	117	6	the	the	DT
cord-267897-w4pbq2lb	117	7	adsorption	adsorption	NN
cord-267897-w4pbq2lb	117	8	have	have	VBP
cord-267897-w4pbq2lb	117	9	been	be	VBN
cord-267897-w4pbq2lb	117	10	explained	explain	VBN
cord-267897-w4pbq2lb	117	11	partly	partly	RB
cord-267897-w4pbq2lb	117	12	by	by	IN
cord-267897-w4pbq2lb	117	13	electrostatic	electrostatic	JJ
cord-267897-w4pbq2lb	117	14	attraction	attraction	NN
cord-267897-w4pbq2lb	117	15	and	and	CC
cord-267897-w4pbq2lb	117	16	partly	partly	RB
cord-267897-w4pbq2lb	117	17	by	by	IN
cord-267897-w4pbq2lb	117	18	anionic	anionic	JJ
cord-267897-w4pbq2lb	117	19	ligand	ligand	NN
cord-267897-w4pbq2lb	117	20	exchange	exchange	NN
cord-267897-w4pbq2lb	117	21	.	.	.
cord-267897-w4pbq2lb	118	1	52	52	CD
cord-267897-w4pbq2lb	119	1	In	in	IN
cord-267897-w4pbq2lb	119	2	addition	addition	NN
cord-267897-w4pbq2lb	119	3	,	,	,
cord-267897-w4pbq2lb	119	4	other	other	JJ
cord-267897-w4pbq2lb	119	5	intermolecular	intermolecular	JJ
cord-267897-w4pbq2lb	119	6	binding	binding	NN
cord-267897-w4pbq2lb	119	7	forces	force	NNS
cord-267897-w4pbq2lb	119	8	,	,	,
cord-267897-w4pbq2lb	119	9	like	like	IN
cord-267897-w4pbq2lb	119	10	hydrophilicehydrophobic	hydrophilicehydrophobic	NNP
cord-267897-w4pbq2lb	119	11	interactions	interaction	NNS
cord-267897-w4pbq2lb	119	12	and	and	CC
cord-267897-w4pbq2lb	119	13	van	van	NNP
cord-267897-w4pbq2lb	119	14	der	der	NNP
cord-267897-w4pbq2lb	119	15	Waals	Waals	NNP
cord-267897-w4pbq2lb	119	16	forces	force	NNS
cord-267897-w4pbq2lb	119	17	,	,	,
cord-267897-w4pbq2lb	119	18	may	may	MD
cord-267897-w4pbq2lb	119	19	play	play	VB
cord-267897-w4pbq2lb	119	20	a	a	DT
cord-267897-w4pbq2lb	119	21	role	role	NN
cord-267897-w4pbq2lb	119	22	in	in	IN
cord-267897-w4pbq2lb	119	23	protein	protein	NN
cord-267897-w4pbq2lb	119	24	adsorption	adsorption	NN
cord-267897-w4pbq2lb	119	25	.	.	.
cord-267897-w4pbq2lb	120	1	53	53	CD
cord-267897-w4pbq2lb	121	1	Each	each	DT
cord-267897-w4pbq2lb	121	2	binding	bind	VBG
cord-267897-w4pbq2lb	121	3	force	force	NN
cord-267897-w4pbq2lb	121	4	plays	play	VBZ
cord-267897-w4pbq2lb	121	5	its	-PRON-	PRP$
cord-267897-w4pbq2lb	121	6	role	role	NN
cord-267897-w4pbq2lb	121	7	in	in	IN
cord-267897-w4pbq2lb	121	8	a	a	DT
cord-267897-w4pbq2lb	121	9	given	give	VBN
cord-267897-w4pbq2lb	121	10	antigeneadjuvant	antigeneadjuvant	NN
cord-267897-w4pbq2lb	121	11	combination	combination	NN
cord-267897-w4pbq2lb	121	12	,	,	,
cord-267897-w4pbq2lb	121	13	depending	depend	VBG
cord-267897-w4pbq2lb	121	14	upon	upon	IN
cord-267897-w4pbq2lb	121	15	the	the	DT
cord-267897-w4pbq2lb	121	16	nature	nature	NN
cord-267897-w4pbq2lb	121	17	of	of	IN
cord-267897-w4pbq2lb	121	18	the	the	DT
cord-267897-w4pbq2lb	121	19	antigen	antigen	NN
cord-267897-w4pbq2lb	121	20	and	and	CC
cord-267897-w4pbq2lb	121	21	the	the	DT
cord-267897-w4pbq2lb	121	22	chemical	chemical	JJ
cord-267897-w4pbq2lb	121	23	environment	environment	NN
cord-267897-w4pbq2lb	121	24	:	:	:
cord-267897-w4pbq2lb	121	25	pH	pH	NNP
cord-267897-w4pbq2lb	121	26	,	,	,
cord-267897-w4pbq2lb	121	27	ionic	ionic	JJ
cord-267897-w4pbq2lb	121	28	strength	strength	NN
cord-267897-w4pbq2lb	121	29	,	,	,
cord-267897-w4pbq2lb	121	30	presence	presence	NN
cord-267897-w4pbq2lb	121	31	of	of	IN
cord-267897-w4pbq2lb	121	32	surfactants	surfactant	NNS
cord-267897-w4pbq2lb	121	33	,	,	,
cord-267897-w4pbq2lb	121	34	etc	etc	FW
cord-267897-w4pbq2lb	121	35	.	.	.
cord-267897-w4pbq2lb	122	1	54e56	54e56	CD
cord-267897-w4pbq2lb	123	1	As	as	IN
cord-267897-w4pbq2lb	123	2	a	a	DT
cord-267897-w4pbq2lb	123	3	general	general	JJ
cord-267897-w4pbq2lb	123	4	guideline	guideline	NN
cord-267897-w4pbq2lb	123	5	,	,	,
cord-267897-w4pbq2lb	123	6	adsorption	adsorption	NN
cord-267897-w4pbq2lb	123	7	by	by	IN
cord-267897-w4pbq2lb	123	8	electrostatic	electrostatic	JJ
cord-267897-w4pbq2lb	123	9	attraction	attraction	NN
cord-267897-w4pbq2lb	123	10	is	be	VBZ
cord-267897-w4pbq2lb	123	11	accomplished	accomplish	VBN
cord-267897-w4pbq2lb	123	12	in	in	IN
cord-267897-w4pbq2lb	123	13	the	the	DT
cord-267897-w4pbq2lb	123	14	pH	pH	NNP
cord-267897-w4pbq2lb	123	15	interval	interval	NN
cord-267897-w4pbq2lb	123	16	between	between	IN
cord-267897-w4pbq2lb	123	17	the	the	DT
cord-267897-w4pbq2lb	123	18	isoelectric	isoelectric	JJ
cord-267897-w4pbq2lb	123	19	point	point	NN
cord-267897-w4pbq2lb	123	20	(	(	-LRB-
cord-267897-w4pbq2lb	123	21	IEP	IEP	NNP
cord-267897-w4pbq2lb	123	22	)	)	-RRB-
cord-267897-w4pbq2lb	123	23	of	of	IN
cord-267897-w4pbq2lb	123	24	the	the	DT
cord-267897-w4pbq2lb	123	25	protein	protein	NN
cord-267897-w4pbq2lb	123	26	antigen	antigen	NN
cord-267897-w4pbq2lb	123	27	and	and	CC
cord-267897-w4pbq2lb	123	28	the	the	DT
cord-267897-w4pbq2lb	123	29	point	point	NN
cord-267897-w4pbq2lb	123	30	of	of	IN
cord-267897-w4pbq2lb	123	31	zero	zero	CD
cord-267897-w4pbq2lb	123	32	charge	charge	NN
cord-267897-w4pbq2lb	123	33	(	(	-LRB-
cord-267897-w4pbq2lb	123	34	PZC	PZC	NNP
cord-267897-w4pbq2lb	123	35	)	)	-RRB-
cord-267897-w4pbq2lb	123	36	of	of	IN
cord-267897-w4pbq2lb	123	37	the	the	DT
cord-267897-w4pbq2lb	123	38	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	123	39	,	,	,
cord-267897-w4pbq2lb	123	40	which	which	WDT
cord-267897-w4pbq2lb	123	41	is	be	VBZ
cord-267897-w4pbq2lb	123	42	the	the	DT
cord-267897-w4pbq2lb	123	43	equivalence	equivalence	NN
cord-267897-w4pbq2lb	123	44	of	of	IN
cord-267897-w4pbq2lb	123	45	the	the	DT
cord-267897-w4pbq2lb	123	46	IEP	IEP	NNP
cord-267897-w4pbq2lb	123	47	,	,	,
cord-267897-w4pbq2lb	123	48	but	but	CC
cord-267897-w4pbq2lb	123	49	for	for	IN
cord-267897-w4pbq2lb	123	50	the	the	DT
cord-267897-w4pbq2lb	123	51	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	123	52	.	.	.
cord-267897-w4pbq2lb	124	1	This	this	DT
cord-267897-w4pbq2lb	124	2	applies	apply	VBZ
cord-267897-w4pbq2lb	124	3	for	for	IN
cord-267897-w4pbq2lb	124	4	both	both	DT
cord-267897-w4pbq2lb	124	5	aluminum	aluminum	NN
cord-267897-w4pbq2lb	124	6	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	124	7	and	and	CC
cord-267897-w4pbq2lb	124	8	aluminum	aluminum	NN
cord-267897-w4pbq2lb	124	9	phosphate	phosphate	NN
cord-267897-w4pbq2lb	124	10	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	124	11	.	.	.
cord-267897-w4pbq2lb	125	1	In	in	IN
cord-267897-w4pbq2lb	125	2	this	this	DT
cord-267897-w4pbq2lb	125	3	interval	interval	NN
cord-267897-w4pbq2lb	125	4	the	the	DT
cord-267897-w4pbq2lb	125	5	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	125	6	and	and	CC
cord-267897-w4pbq2lb	125	7	the	the	DT
cord-267897-w4pbq2lb	125	8	antigen	antigen	NN
cord-267897-w4pbq2lb	125	9	will	will	MD
cord-267897-w4pbq2lb	125	10	have	have	VB
cord-267897-w4pbq2lb	125	11	opposite	opposite	JJ
cord-267897-w4pbq2lb	125	12	electrical	electrical	JJ
cord-267897-w4pbq2lb	125	13	charges	charge	NNS
cord-267897-w4pbq2lb	125	14	,	,	,
cord-267897-w4pbq2lb	125	15	facilitating	facilitate	VBG
cord-267897-w4pbq2lb	125	16	electrostatic	electrostatic	JJ
cord-267897-w4pbq2lb	125	17	attraction	attraction	NN
cord-267897-w4pbq2lb	125	18	and	and	CC
cord-267897-w4pbq2lb	125	19	adsorption	adsorption	NN
cord-267897-w4pbq2lb	125	20	(	(	-LRB-
cord-267897-w4pbq2lb	125	21	Fig	Fig	NNP
cord-267897-w4pbq2lb	125	22	.	.	.
cord-267897-w4pbq2lb	125	23	18	18	CD
cord-267897-w4pbq2lb	125	24	.3	.3	CD
cord-267897-w4pbq2lb	125	25	)	)	-RRB-
cord-267897-w4pbq2lb	125	26	.	.	.
cord-267897-w4pbq2lb	126	1	The	the	DT
cord-267897-w4pbq2lb	126	2	surface	surface	NN
cord-267897-w4pbq2lb	126	3	charge	charge	NN
cord-267897-w4pbq2lb	126	4	(	(	-LRB-
cord-267897-w4pbq2lb	126	5	SCh	SCh	NNS
cord-267897-w4pbq2lb	126	6	)	)	-RRB-
cord-267897-w4pbq2lb	126	7	in	in	IN
cord-267897-w4pbq2lb	126	8	millivolts	millivolt	NNS
cord-267897-w4pbq2lb	126	9	of	of	IN
cord-267897-w4pbq2lb	126	10	the	the	DT
cord-267897-w4pbq2lb	126	11	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	126	12	particle	particle	NN
cord-267897-w4pbq2lb	126	13	at	at	IN
cord-267897-w4pbq2lb	126	14	25	25	CD
cord-267897-w4pbq2lb	126	15	C	C	NNP
cord-267897-w4pbq2lb	126	16	was	be	VBD
cord-267897-w4pbq2lb	126	17	described	describe	VBN
cord-267897-w4pbq2lb	126	18	by	by	IN
cord-267897-w4pbq2lb	126	19	the	the	DT
cord-267897-w4pbq2lb	126	20	formula	formula	NN
cord-267897-w4pbq2lb	126	21	(	(	-LRB-
cord-267897-w4pbq2lb	126	22	Stanley	Stanley	NNP
cord-267897-w4pbq2lb	126	23	L.	L.	NNP
cord-267897-w4pbq2lb	126	24	Hem	Hem	NNP
cord-267897-w4pbq2lb	126	25	,	,	,
cord-267897-w4pbq2lb	126	26	personal	personal	JJ
cord-267897-w4pbq2lb	126	27	communication	communication	NN
cord-267897-w4pbq2lb	126	28	)	)	-RRB-
cord-267897-w4pbq2lb	126	29	:	:	:
cord-267897-w4pbq2lb	126	30	In	in	IN
cord-267897-w4pbq2lb	126	31	this	this	DT
cord-267897-w4pbq2lb	126	32	formula	formula	NN
cord-267897-w4pbq2lb	126	33	,	,	,
cord-267897-w4pbq2lb	126	34	which	which	WDT
cord-267897-w4pbq2lb	126	35	is	be	VBZ
cord-267897-w4pbq2lb	126	36	derived	derive	VBN
cord-267897-w4pbq2lb	126	37	from	from	IN
cord-267897-w4pbq2lb	126	38	the	the	DT
cord-267897-w4pbq2lb	126	39	Nernst	Nernst	NNP
cord-267897-w4pbq2lb	126	40	equation	equation	NN
cord-267897-w4pbq2lb	126	41	,	,	,
cord-267897-w4pbq2lb	126	42	"	"	``
cord-267897-w4pbq2lb	126	43	PZC	PZC	NNP
cord-267897-w4pbq2lb	126	44	"	"	''
cord-267897-w4pbq2lb	126	45	is	be	VBZ
cord-267897-w4pbq2lb	126	46	the	the	DT
cord-267897-w4pbq2lb	126	47	pH	pH	NNP
cord-267897-w4pbq2lb	126	48	value	value	NN
cord-267897-w4pbq2lb	126	49	at	at	IN
cord-267897-w4pbq2lb	126	50	which	which	WDT
cord-267897-w4pbq2lb	126	51	the	the	DT
cord-267897-w4pbq2lb	126	52	net	net	JJ
cord-267897-w4pbq2lb	126	53	charge	charge	NN
cord-267897-w4pbq2lb	126	54	of	of	IN
cord-267897-w4pbq2lb	126	55	the	the	DT
cord-267897-w4pbq2lb	126	56	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	126	57	is	be	VBZ
cord-267897-w4pbq2lb	126	58	zero	zero	CD
cord-267897-w4pbq2lb	126	59	and	and	CC
cord-267897-w4pbq2lb	127	1	"	"	``
cord-267897-w4pbq2lb	127	2	pH	pH	NNP
cord-267897-w4pbq2lb	127	3	"	"	''
cord-267897-w4pbq2lb	127	4	is	be	VBZ
cord-267897-w4pbq2lb	127	5	the	the	DT
cord-267897-w4pbq2lb	127	6	actual	actual	JJ
cord-267897-w4pbq2lb	127	7	pH	pH	NNP
cord-267897-w4pbq2lb	127	8	value	value	NN
cord-267897-w4pbq2lb	127	9	of	of	IN
cord-267897-w4pbq2lb	127	10	the	the	DT
cord-267897-w4pbq2lb	127	11	chemical	chemical	JJ
cord-267897-w4pbq2lb	127	12	environment	environment	NN
cord-267897-w4pbq2lb	127	13	.	.	.
cord-267897-w4pbq2lb	128	1	Sally	Sally	NNP
cord-267897-w4pbq2lb	128	2	Seeber	Seeber	NNP
cord-267897-w4pbq2lb	128	3	and	and	CC
cord-267897-w4pbq2lb	128	4	coworkers	coworker	NNS
cord-267897-w4pbq2lb	128	5	57	57	CD
cord-267897-w4pbq2lb	128	6	concluded	conclude	VBD
cord-267897-w4pbq2lb	128	7	that	that	IN
cord-267897-w4pbq2lb	128	8	aluminum	aluminum	NN
cord-267897-w4pbq2lb	128	9	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	128	10	should	should	MD
cord-267897-w4pbq2lb	128	11	be	be	VB
cord-267897-w4pbq2lb	128	12	superior	superior	JJ
cord-267897-w4pbq2lb	128	13	to	to	TO
cord-267897-w4pbq2lb	128	14	aluminum	aluminum	NN
cord-267897-w4pbq2lb	128	15	phosphate	phosphate	NN
cord-267897-w4pbq2lb	128	16	in	in	IN
cord-267897-w4pbq2lb	128	17	adsorbing	adsorb	VBG
cord-267897-w4pbq2lb	128	18	proteins	protein	NNS
cord-267897-w4pbq2lb	128	19	with	with	IN
cord-267897-w4pbq2lb	128	20	an	an	DT
cord-267897-w4pbq2lb	128	21	acid	acid	NN
cord-267897-w4pbq2lb	128	22	IEP	IEP	NNP
cord-267897-w4pbq2lb	128	23	,	,	,
cord-267897-w4pbq2lb	128	24	and	and	CC
cord-267897-w4pbq2lb	128	25	vice	vice	NN
cord-267897-w4pbq2lb	128	26	versa	versa	RB
cord-267897-w4pbq2lb	128	27	for	for	IN
cord-267897-w4pbq2lb	128	28	proteins	protein	NNS
cord-267897-w4pbq2lb	128	29	with	with	IN
cord-267897-w4pbq2lb	128	30	an	an	DT
cord-267897-w4pbq2lb	128	31	alkaline	alkaline	JJ
cord-267897-w4pbq2lb	128	32	IEP	IEP	NNP
cord-267897-w4pbq2lb	128	33	.	.	.
cord-267897-w4pbq2lb	129	1	However	however	RB
cord-267897-w4pbq2lb	129	2	,	,	,
cord-267897-w4pbq2lb	129	3	antigens	antigen	NNS
cord-267897-w4pbq2lb	129	4	with	with	IN
cord-267897-w4pbq2lb	129	5	a	a	DT
cord-267897-w4pbq2lb	129	6	distinct	distinct	JJ
cord-267897-w4pbq2lb	129	7	polarity	polarity	NN
cord-267897-w4pbq2lb	129	8	in	in	IN
cord-267897-w4pbq2lb	129	9	terms	term	NNS
cord-267897-w4pbq2lb	129	10	of	of	IN
cord-267897-w4pbq2lb	129	11	one	one	CD
cord-267897-w4pbq2lb	129	12	part	part	NN
cord-267897-w4pbq2lb	129	13	of	of	IN
cord-267897-w4pbq2lb	129	14	the	the	DT
cord-267897-w4pbq2lb	129	15	molecule	molecule	NN
cord-267897-w4pbq2lb	129	16	having	have	VBG
cord-267897-w4pbq2lb	129	17	a	a	DT
cord-267897-w4pbq2lb	129	18	clearly	clearly	RB
cord-267897-w4pbq2lb	129	19	acidic	acidic	JJ
cord-267897-w4pbq2lb	129	20	IEP	IEP	NNP
cord-267897-w4pbq2lb	129	21	and	and	CC
cord-267897-w4pbq2lb	129	22	a	a	DT
cord-267897-w4pbq2lb	129	23	distant	distant	JJ
cord-267897-w4pbq2lb	129	24	part	part	NN
cord-267897-w4pbq2lb	129	25	of	of	IN
cord-267897-w4pbq2lb	129	26	the	the	DT
cord-267897-w4pbq2lb	129	27	same	same	JJ
cord-267897-w4pbq2lb	129	28	molecule	molecule	NN
cord-267897-w4pbq2lb	129	29	having	have	VBG
cord-267897-w4pbq2lb	129	30	a	a	DT
cord-267897-w4pbq2lb	129	31	clearly	clearly	RB
cord-267897-w4pbq2lb	129	32	alkaline	alkaline	JJ
cord-267897-w4pbq2lb	129	33	IEP	IEP	NNP
cord-267897-w4pbq2lb	129	34	may	may	MD
cord-267897-w4pbq2lb	129	35	bind	bind	VB
cord-267897-w4pbq2lb	129	36	well	well	RB
cord-267897-w4pbq2lb	129	37	to	to	IN
cord-267897-w4pbq2lb	129	38	both	both	DT
cord-267897-w4pbq2lb	129	39	,	,	,
cord-267897-w4pbq2lb	129	40	e.g.	e.g.	RB
cord-267897-w4pbq2lb	129	41	,	,	,
cord-267897-w4pbq2lb	129	42	Al(OH	al(oh	ADD
cord-267897-w4pbq2lb	129	43	)	)	-RRB-
cord-267897-w4pbq2lb	129	44	3	3	CD
cord-267897-w4pbq2lb	130	1	and	and	CC
cord-267897-w4pbq2lb	130	2	AlPO	AlPO	NNP
cord-267897-w4pbq2lb	130	3	4	4	CD
cord-267897-w4pbq2lb	130	4	,	,	,
cord-267897-w4pbq2lb	130	5	by	by	IN
cord-267897-w4pbq2lb	130	6	electrostatic	electrostatic	JJ
cord-267897-w4pbq2lb	130	7	attraction	attraction	NN
cord-267897-w4pbq2lb	130	8	.	.	.
cord-267897-w4pbq2lb	131	1	However	however	RB
cord-267897-w4pbq2lb	131	2	,	,	,
cord-267897-w4pbq2lb	131	3	in	in	IN
cord-267897-w4pbq2lb	131	4	such	such	JJ
cord-267897-w4pbq2lb	131	5	cases	case	NNS
cord-267897-w4pbq2lb	131	6	there	there	EX
cord-267897-w4pbq2lb	131	7	may	may	MD
cord-267897-w4pbq2lb	131	8	be	be	VB
cord-267897-w4pbq2lb	131	9	a	a	DT
cord-267897-w4pbq2lb	131	10	difference	difference	NN
cord-267897-w4pbq2lb	131	11	in	in	IN
cord-267897-w4pbq2lb	131	12	the	the	DT
cord-267897-w4pbq2lb	131	13	orientation	orientation	NN
cord-267897-w4pbq2lb	131	14	of	of	IN
cord-267897-w4pbq2lb	131	15	the	the	DT
cord-267897-w4pbq2lb	131	16	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	131	17	molecule	molecule	NN
cord-267897-w4pbq2lb	131	18	in	in	IN
cord-267897-w4pbq2lb	131	19	relation	relation	NN
cord-267897-w4pbq2lb	131	20	to	to	IN
cord-267897-w4pbq2lb	131	21	the	the	DT
cord-267897-w4pbq2lb	131	22	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	131	23	.	.	.
cord-267897-w4pbq2lb	132	1	58	58	CD
cord-267897-w4pbq2lb	133	1	Ligand	Ligand	NNP
cord-267897-w4pbq2lb	133	2	Exchange	Exchange	NNP
cord-267897-w4pbq2lb	134	1	If	if	IN
cord-267897-w4pbq2lb	134	2	the	the	DT
cord-267897-w4pbq2lb	134	3	antigen	antigen	NN
cord-267897-w4pbq2lb	134	4	contains	contain	VBZ
cord-267897-w4pbq2lb	134	5	phosphorylated	phosphorylated	JJ
cord-267897-w4pbq2lb	134	6	groups	group	NNS
cord-267897-w4pbq2lb	134	7	(	(	-LRB-
cord-267897-w4pbq2lb	134	8	e.g.	e.g.	RB
cord-267897-w4pbq2lb	134	9	,	,	,
cord-267897-w4pbq2lb	134	10	phosphorylated	phosphorylated	JJ
cord-267897-w4pbq2lb	134	11	amino	amino	JJ
cord-267897-w4pbq2lb	134	12	acids	acid	NNS
cord-267897-w4pbq2lb	134	13	)	)	-RRB-
cord-267897-w4pbq2lb	134	14	,	,	,
cord-267897-w4pbq2lb	134	15	ligand	ligand	NN
cord-267897-w4pbq2lb	134	16	exchange	exchange	NN
cord-267897-w4pbq2lb	134	17	between	between	IN
cord-267897-w4pbq2lb	134	18	the	the	DT
cord-267897-w4pbq2lb	134	19	antigen	antigen	NN
cord-267897-w4pbq2lb	134	20	-	-	HYPH
cord-267897-w4pbq2lb	134	21	associated	associate	VBN
cord-267897-w4pbq2lb	134	22	phosphate	phosphate	NN
cord-267897-w4pbq2lb	134	23	and	and	CC
cord-267897-w4pbq2lb	134	24	hydroxyl	hydroxyl	NN
cord-267897-w4pbq2lb	134	25	groups	group	NNS
cord-267897-w4pbq2lb	134	26	of	of	IN
cord-267897-w4pbq2lb	134	27	the	the	DT
cord-267897-w4pbq2lb	134	28	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	134	29	may	may	MD
cord-267897-w4pbq2lb	134	30	account	account	VB
cord-267897-w4pbq2lb	134	31	for	for	IN
cord-267897-w4pbq2lb	134	32	high	high	JJ
cord-267897-w4pbq2lb	134	33	-	-	HYPH
cord-267897-w4pbq2lb	134	34	affinity	affinity	NN
cord-267897-w4pbq2lb	134	35	binding	binding	NN
cord-267897-w4pbq2lb	134	36	to	to	IN
cord-267897-w4pbq2lb	134	37	the	the	DT
cord-267897-w4pbq2lb	134	38	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	134	39	.	.	.
cord-267897-w4pbq2lb	135	1	This	this	DT
cord-267897-w4pbq2lb	135	2	is	be	VBZ
cord-267897-w4pbq2lb	135	3	the	the	DT
cord-267897-w4pbq2lb	135	4	case	case	NN
cord-267897-w4pbq2lb	135	5	,	,	,
cord-267897-w4pbq2lb	135	6	e.g.	e.g.	RB
cord-267897-w4pbq2lb	135	7	,	,	,
cord-267897-w4pbq2lb	135	8	with	with	IN
cord-267897-w4pbq2lb	135	9	hepatitis	hepatitis	NNP
cord-267897-w4pbq2lb	135	10	B	B	NNP
cord-267897-w4pbq2lb	135	11	virus	virus	NN
cord-267897-w4pbq2lb	135	12	surface	surface	NN
cord-267897-w4pbq2lb	135	13	antigen	antigen	NN
cord-267897-w4pbq2lb	135	14	(	(	-LRB-
cord-267897-w4pbq2lb	135	15	HBsAg	HBsAg	NNP
cord-267897-w4pbq2lb	135	16	)	)	-RRB-
cord-267897-w4pbq2lb	135	17	particles	particle	VBZ
cord-267897-w4pbq2lb	135	18	59	59	CD
cord-267897-w4pbq2lb	135	19	and	and	CC
cord-267897-w4pbq2lb	135	20	has	have	VBZ
cord-267897-w4pbq2lb	135	21	been	be	VBN
cord-267897-w4pbq2lb	135	22	shown	show	VBN
cord-267897-w4pbq2lb	135	23	in	in	IN
cord-267897-w4pbq2lb	135	24	experiments	experiment	NNS
cord-267897-w4pbq2lb	135	25	using	use	VBG
cord-267897-w4pbq2lb	135	26	phosphorylated	phosphorylated	JJ
cord-267897-w4pbq2lb	135	27	alpha	alpha	NN
cord-267897-w4pbq2lb	135	28	-	-	HYPH
cord-267897-w4pbq2lb	135	29	casein	casein	NN
cord-267897-w4pbq2lb	135	30	as	as	IN
cord-267897-w4pbq2lb	135	31	model	model	NN
cord-267897-w4pbq2lb	135	32	antigen	antigen	NN
cord-267897-w4pbq2lb	135	33	.	.	.
cord-267897-w4pbq2lb	136	1	60	60	CD
cord-267897-w4pbq2lb	136	2	Ligand	Ligand	NNP
cord-267897-w4pbq2lb	136	3	exchange	exchange	NN
cord-267897-w4pbq2lb	136	4	involves	involve	VBZ
cord-267897-w4pbq2lb	136	5	substitution	substitution	NN
cord-267897-w4pbq2lb	136	6	of	of	IN
cord-267897-w4pbq2lb	136	7	surface	surface	NN
cord-267897-w4pbq2lb	136	8	-	-	HYPH
cord-267897-w4pbq2lb	136	9	associated	associate	VBN
cord-267897-w4pbq2lb	136	10	hydroxyl	hydroxyl	NN
cord-267897-w4pbq2lb	136	11	groups	group	NNS
cord-267897-w4pbq2lb	136	12	with	with	IN
cord-267897-w4pbq2lb	136	13	phosphate	phosphate	NN
cord-267897-w4pbq2lb	136	14	groups	group	NNS
cord-267897-w4pbq2lb	136	15	and	and	CC
cord-267897-w4pbq2lb	136	16	leads	lead	VBZ
cord-267897-w4pbq2lb	136	17	to	to	IN
cord-267897-w4pbq2lb	136	18	a	a	DT
cord-267897-w4pbq2lb	136	19	decrease	decrease	NN
cord-267897-w4pbq2lb	136	20	of	of	IN
cord-267897-w4pbq2lb	136	21	the	the	DT
cord-267897-w4pbq2lb	136	22	PZC	PZC	NNP
cord-267897-w4pbq2lb	136	23	of	of	IN
cord-267897-w4pbq2lb	136	24	the	the	DT
cord-267897-w4pbq2lb	136	25	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	136	26	.	.	.
cord-267897-w4pbq2lb	137	1	Adsorption	adsorption	NN
cord-267897-w4pbq2lb	137	2	due	due	IN
cord-267897-w4pbq2lb	137	3	to	to	IN
cord-267897-w4pbq2lb	137	4	ligand	ligand	NN
cord-267897-w4pbq2lb	137	5	exchange	exchange	NN
cord-267897-w4pbq2lb	137	6	may	may	MD
cord-267897-w4pbq2lb	137	7	take	take	VB
cord-267897-w4pbq2lb	137	8	place	place	NN
cord-267897-w4pbq2lb	137	9	even	even	RB
cord-267897-w4pbq2lb	137	10	in	in	IN
cord-267897-w4pbq2lb	137	11	systems	system	NNS
cord-267897-w4pbq2lb	137	12	in	in	IN
cord-267897-w4pbq2lb	137	13	which	which	WDT
cord-267897-w4pbq2lb	137	14	the	the	DT
cord-267897-w4pbq2lb	137	15	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	137	16	and	and	CC
cord-267897-w4pbq2lb	137	17	the	the	DT
cord-267897-w4pbq2lb	137	18	antigen	antigen	NN
cord-267897-w4pbq2lb	137	19	have	have	VBP
cord-267897-w4pbq2lb	137	20	the	the	DT
cord-267897-w4pbq2lb	137	21	same	same	JJ
cord-267897-w4pbq2lb	137	22	electrical	electrical	JJ
cord-267897-w4pbq2lb	137	23	charge	charge	NN
cord-267897-w4pbq2lb	137	24	and	and	CC
cord-267897-w4pbq2lb	137	25	electrostatic	electrostatic	JJ
cord-267897-w4pbq2lb	137	26	repulsion	repulsion	NN
cord-267897-w4pbq2lb	137	27	would	would	MD
cord-267897-w4pbq2lb	137	28	be	be	VB
cord-267897-w4pbq2lb	137	29	expected	expect	VBN
cord-267897-w4pbq2lb	137	30	.	.	.
cord-267897-w4pbq2lb	138	1	60	60	CD
cord-267897-w4pbq2lb	138	2	 	 	_SP
cord-267897-w4pbq2lb	138	3	Determination	determination	NN
cord-267897-w4pbq2lb	138	4	of	of	IN
cord-267897-w4pbq2lb	138	5	the	the	DT
cord-267897-w4pbq2lb	138	6	protein	protein	NN
cord-267897-w4pbq2lb	138	7	adsorption	adsorption	NN
cord-267897-w4pbq2lb	138	8	capacity	capacity	NN
cord-267897-w4pbq2lb	138	9	of	of	IN
cord-267897-w4pbq2lb	138	10	the	the	DT
cord-267897-w4pbq2lb	138	11	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	138	12	is	be	VBZ
cord-267897-w4pbq2lb	138	13	highly	highly	RB
cord-267897-w4pbq2lb	138	14	recommended	recommend	VBN
cord-267897-w4pbq2lb	138	15	and	and	CC
cord-267897-w4pbq2lb	138	16	can	can	MD
cord-267897-w4pbq2lb	138	17	be	be	VB
cord-267897-w4pbq2lb	138	18	measured	measure	VBN
cord-267897-w4pbq2lb	138	19	by	by	IN
cord-267897-w4pbq2lb	138	20	a	a	DT
cord-267897-w4pbq2lb	138	21	variety	variety	NN
cord-267897-w4pbq2lb	138	22	of	of	IN
cord-267897-w4pbq2lb	138	23	analytical	analytical	JJ
cord-267897-w4pbq2lb	138	24	methods	method	NNS
cord-267897-w4pbq2lb	138	25	.	.	.
cord-267897-w4pbq2lb	139	1	It	-PRON-	PRP
cord-267897-w4pbq2lb	139	2	is	be	VBZ
cord-267897-w4pbq2lb	139	3	normally	normally	RB
cord-267897-w4pbq2lb	139	4	done	do	VBN
cord-267897-w4pbq2lb	139	5	by	by	IN
cord-267897-w4pbq2lb	139	6	comparing	compare	VBG
cord-267897-w4pbq2lb	139	7	the	the	DT
cord-267897-w4pbq2lb	139	8	protein	protein	NN
cord-267897-w4pbq2lb	139	9	content	content	NN
cord-267897-w4pbq2lb	139	10	in	in	IN
cord-267897-w4pbq2lb	139	11	the	the	DT
cord-267897-w4pbq2lb	139	12	aqueous	aqueous	JJ
cord-267897-w4pbq2lb	139	13	phase	phase	NN
cord-267897-w4pbq2lb	139	14	of	of	IN
cord-267897-w4pbq2lb	139	15	the	the	DT
cord-267897-w4pbq2lb	139	16	antigen	antigen	NN
cord-267897-w4pbq2lb	139	17	solution	solution	NN
cord-267897-w4pbq2lb	139	18	before	before	IN
cord-267897-w4pbq2lb	139	19	and	and	CC
cord-267897-w4pbq2lb	139	20	after	after	IN
cord-267897-w4pbq2lb	139	21	adsorption	adsorption	NN
cord-267897-w4pbq2lb	139	22	onto	onto	IN
cord-267897-w4pbq2lb	139	23	the	the	DT
cord-267897-w4pbq2lb	139	24	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	139	25	.	.	.
cord-267897-w4pbq2lb	140	1	If	if	IN
cord-267897-w4pbq2lb	140	2	an	an	DT
cord-267897-w4pbq2lb	140	3	antibody	antibody	NN
cord-267897-w4pbq2lb	140	4	specific	specific	JJ
cord-267897-w4pbq2lb	140	5	for	for	IN
cord-267897-w4pbq2lb	140	6	the	the	DT
cord-267897-w4pbq2lb	140	7	antigen	antigen	NN
cord-267897-w4pbq2lb	140	8	one	one	CD
cord-267897-w4pbq2lb	140	9	wishes	wish	VBZ
cord-267897-w4pbq2lb	140	10	to	to	TO
cord-267897-w4pbq2lb	140	11	adsorb	adsorb	VB
cord-267897-w4pbq2lb	140	12	is	be	VBZ
cord-267897-w4pbq2lb	140	13	available	available	JJ
cord-267897-w4pbq2lb	140	14	,	,	,
cord-267897-w4pbq2lb	140	15	adsorption	adsorption	NN
cord-267897-w4pbq2lb	140	16	can	can	MD
cord-267897-w4pbq2lb	140	17	be	be	VB
cord-267897-w4pbq2lb	140	18	measured	measure	VBN
cord-267897-w4pbq2lb	140	19	by	by	IN
cord-267897-w4pbq2lb	140	20	immunoprecipitation	immunoprecipitation	NN
cord-267897-w4pbq2lb	140	21	techniques	technique	NNS
cord-267897-w4pbq2lb	140	22	.	.	.
cord-267897-w4pbq2lb	141	1	It	-PRON-	PRP
cord-267897-w4pbq2lb	141	2	can	can	MD
cord-267897-w4pbq2lb	141	3	be	be	VB
cord-267897-w4pbq2lb	141	4	done	do	VBN
cord-267897-w4pbq2lb	141	5	by	by	IN
cord-267897-w4pbq2lb	141	6	quantitative	quantitative	JJ
cord-267897-w4pbq2lb	141	7	immunoelectrophoresis	immunoelectrophoresis	NNP
cord-267897-w4pbq2lb	141	8	61	61	CD
cord-267897-w4pbq2lb	141	9	or	or	CC
cord-267897-w4pbq2lb	141	10	by	by	IN
cord-267897-w4pbq2lb	141	11	single	single	JJ
cord-267897-w4pbq2lb	141	12	radial	radial	JJ
cord-267897-w4pbq2lb	141	13	immunodiffusion	immunodiffusion	NN
cord-267897-w4pbq2lb	141	14	.	.	.
cord-267897-w4pbq2lb	142	1	62	62	CD
cord-267897-w4pbq2lb	143	1	Without	without	IN
cord-267897-w4pbq2lb	143	2	the	the	DT
cord-267897-w4pbq2lb	143	3	use	use	NN
cord-267897-w4pbq2lb	143	4	of	of	IN
cord-267897-w4pbq2lb	143	5	an	an	DT
cord-267897-w4pbq2lb	143	6	antibody	antibody	NN
cord-267897-w4pbq2lb	143	7	it	-PRON-	PRP
cord-267897-w4pbq2lb	143	8	can	can	MD
cord-267897-w4pbq2lb	143	9	be	be	VB
cord-267897-w4pbq2lb	143	10	tested	test	VBN
cord-267897-w4pbq2lb	143	11	spectrophotometrically	spectrophotometrically	RB
cord-267897-w4pbq2lb	143	12	,	,	,
cord-267897-w4pbq2lb	143	13	e.g.	e.g.	RB
cord-267897-w4pbq2lb	143	14	,	,	,
cord-267897-w4pbq2lb	143	15	by	by	IN
cord-267897-w4pbq2lb	143	16	the	the	DT
cord-267897-w4pbq2lb	143	17	bicinchoninic	bicinchoninic	NNP
cord-267897-w4pbq2lb	143	18	acid	acid	NNP
cord-267897-w4pbq2lb	143	19	or	or	CC
cord-267897-w4pbq2lb	143	20	BCA	BCA	NNP
cord-267897-w4pbq2lb	143	21	method	method	NN
cord-267897-w4pbq2lb	143	22	.	.	.
cord-267897-w4pbq2lb	144	1	63	63	CD
cord-267897-w4pbq2lb	145	1	However	however	RB
cord-267897-w4pbq2lb	145	2	,	,	,
cord-267897-w4pbq2lb	145	3	one	one	PRP
cord-267897-w4pbq2lb	145	4	should	should	MD
cord-267897-w4pbq2lb	145	5	be	be	VB
cord-267897-w4pbq2lb	145	6	aware	aware	JJ
cord-267897-w4pbq2lb	145	7	that	that	IN
cord-267897-w4pbq2lb	145	8	contamination	contamination	NN
cord-267897-w4pbq2lb	145	9	with	with	IN
cord-267897-w4pbq2lb	145	10	the	the	DT
cord-267897-w4pbq2lb	145	11	fine	fine	JJ
cord-267897-w4pbq2lb	145	12	fraction	fraction	NN
cord-267897-w4pbq2lb	145	13	of	of	IN
cord-267897-w4pbq2lb	145	14	mineral	mineral	NN
cord-267897-w4pbq2lb	145	15	gel	gel	NN
cord-267897-w4pbq2lb	145	16	particles	particle	NNS
cord-267897-w4pbq2lb	145	17	can	can	MD
cord-267897-w4pbq2lb	145	18	disturb	disturb	VB
cord-267897-w4pbq2lb	145	19	the	the	DT
cord-267897-w4pbq2lb	145	20	spectrophotometrical	spectrophotometrical	JJ
cord-267897-w4pbq2lb	145	21	readings	reading	NNS
cord-267897-w4pbq2lb	145	22	by	by	IN
cord-267897-w4pbq2lb	145	23	light	light	JJ
cord-267897-w4pbq2lb	145	24	-	-	HYPH
cord-267897-w4pbq2lb	145	25	scatter	scatter	NN
cord-267897-w4pbq2lb	145	26	effects	effect	NNS
cord-267897-w4pbq2lb	145	27	.	.	.
cord-267897-w4pbq2lb	146	1	Enzyme	enzyme	NN
cord-267897-w4pbq2lb	146	2	-	-	HYPH
cord-267897-w4pbq2lb	146	3	linked	link	VBN
cord-267897-w4pbq2lb	146	4	immunosorbent	immunosorbent	JJ
cord-267897-w4pbq2lb	146	5	assay	assay	NN
cord-267897-w4pbq2lb	146	6	(	(	-LRB-
cord-267897-w4pbq2lb	146	7	ELISA	ELISA	NNP
cord-267897-w4pbq2lb	146	8	)	)	-RRB-
cord-267897-w4pbq2lb	146	9	methods	method	NNS
cord-267897-w4pbq2lb	146	10	have	have	VBP
cord-267897-w4pbq2lb	146	11	been	be	VBN
cord-267897-w4pbq2lb	146	12	designed	design	VBN
cord-267897-w4pbq2lb	146	13	64	64	CD
cord-267897-w4pbq2lb	146	14	in	in	IN
cord-267897-w4pbq2lb	146	15	which	which	WDT
cord-267897-w4pbq2lb	146	16	aluminum	aluminum	NN
cord-267897-w4pbq2lb	146	17	-	-	HYPH
cord-267897-w4pbq2lb	146	18	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	146	19	antigens	antigen	NNS
cord-267897-w4pbq2lb	146	20	could	could	MD
cord-267897-w4pbq2lb	146	21	be	be	VB
cord-267897-w4pbq2lb	146	22	used	use	VBN
cord-267897-w4pbq2lb	146	23	directly	directly	RB
cord-267897-w4pbq2lb	146	24	as	as	IN
cord-267897-w4pbq2lb	146	25	antigens	antigen	NNS
cord-267897-w4pbq2lb	146	26	in	in	IN
cord-267897-w4pbq2lb	146	27	ELISA	ELISA	NNP
cord-267897-w4pbq2lb	146	28	assays	assay	NNS
cord-267897-w4pbq2lb	146	29	.	.	.
cord-267897-w4pbq2lb	147	1	ELISA	ELISA	NNP
cord-267897-w4pbq2lb	147	2	methods	method	NNS
cord-267897-w4pbq2lb	147	3	were	be	VBD
cord-267897-w4pbq2lb	147	4	also	also	RB
cord-267897-w4pbq2lb	147	5	applied	apply	VBN
cord-267897-w4pbq2lb	147	6	for	for	IN
cord-267897-w4pbq2lb	147	7	in	in	IN
cord-267897-w4pbq2lb	147	8	vitro	vitro	FW
cord-267897-w4pbq2lb	147	9	assessment	assessment	NN
cord-267897-w4pbq2lb	147	10	of	of	IN
cord-267897-w4pbq2lb	147	11	various	various	JJ
cord-267897-w4pbq2lb	147	12	viral	viral	JJ
cord-267897-w4pbq2lb	147	13	antigens	antigen	NNS
cord-267897-w4pbq2lb	147	14	,	,	,
cord-267897-w4pbq2lb	147	15	i.e.	i.e.	FW
cord-267897-w4pbq2lb	147	16	,	,	,
cord-267897-w4pbq2lb	147	17	pseudorabies	pseudorabies	NN
cord-267897-w4pbq2lb	147	18	,	,	,
cord-267897-w4pbq2lb	147	19	porcine	porcine	JJ
cord-267897-w4pbq2lb	147	20	parvovirus	parvovirus	NN
cord-267897-w4pbq2lb	147	21	,	,	,
cord-267897-w4pbq2lb	147	22	and	and	CC
cord-267897-w4pbq2lb	147	23	infectious	infectious	JJ
cord-267897-w4pbq2lb	147	24	bovine	bovine	JJ
cord-267897-w4pbq2lb	147	25	rhinotracheitis	rhinotracheitis	NN
cord-267897-w4pbq2lb	147	26	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	147	27	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	147	28	onto	onto	IN
cord-267897-w4pbq2lb	147	29	aluminum	aluminum	NN
cord-267897-w4pbq2lb	147	30	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	147	31	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	147	32	.	.	.
cord-267897-w4pbq2lb	148	1	65	65	CD
cord-267897-w4pbq2lb	148	2	Differential	differential	JJ
cord-267897-w4pbq2lb	148	3	adsorption	adsorption	NN
cord-267897-w4pbq2lb	148	4	of	of	IN
cord-267897-w4pbq2lb	148	5	complex	complex	JJ
cord-267897-w4pbq2lb	148	6	mixtures	mixture	NNS
cord-267897-w4pbq2lb	148	7	of	of	IN
cord-267897-w4pbq2lb	148	8	antigens	antigen	NNS
cord-267897-w4pbq2lb	148	9	can	can	MD
cord-267897-w4pbq2lb	148	10	be	be	VB
cord-267897-w4pbq2lb	148	11	measured	measure	VBN
cord-267897-w4pbq2lb	148	12	by	by	IN
cord-267897-w4pbq2lb	148	13	either	either	DT
cord-267897-w4pbq2lb	148	14	immunoelectrophoresis	immunoelectrophoresis	NN
cord-267897-w4pbq2lb	148	15	or	or	CC
cord-267897-w4pbq2lb	148	16	by	by	IN
cord-267897-w4pbq2lb	148	17	high	high	JJ
cord-267897-w4pbq2lb	148	18	-	-	HYPH
cord-267897-w4pbq2lb	148	19	performance	performance	NN
cord-267897-w4pbq2lb	148	20	liquid	liquid	NN
cord-267897-w4pbq2lb	148	21	chromatography	chromatography	NN
cord-267897-w4pbq2lb	148	22	(	(	-LRB-
cord-267897-w4pbq2lb	148	23	HPLC	HPLC	NNP
cord-267897-w4pbq2lb	148	24	)	)	-RRB-
cord-267897-w4pbq2lb	148	25	.	.	.
cord-267897-w4pbq2lb	149	1	If	if	IN
cord-267897-w4pbq2lb	149	2	an	an	DT
cord-267897-w4pbq2lb	149	3	antiserum	antiserum	NN
cord-267897-w4pbq2lb	149	4	raised	raise	VBN
cord-267897-w4pbq2lb	149	5	against	against	IN
cord-267897-w4pbq2lb	149	6	the	the	DT
cord-267897-w4pbq2lb	149	7	complex	complex	JJ
cord-267897-w4pbq2lb	149	8	antigen	antigen	NN
cord-267897-w4pbq2lb	149	9	mixture	mixture	NN
cord-267897-w4pbq2lb	149	10	is	be	VBZ
cord-267897-w4pbq2lb	149	11	available	available	JJ
cord-267897-w4pbq2lb	149	12	,	,	,
cord-267897-w4pbq2lb	149	13	a	a	DT
cord-267897-w4pbq2lb	149	14	crossed	crossed	JJ
cord-267897-w4pbq2lb	149	15	,	,	,
cord-267897-w4pbq2lb	149	16	twodimensional	twodimensional	NNP
cord-267897-w4pbq2lb	149	17	immunoelectrophoresis	immunoelectrophoresis	NNP
cord-267897-w4pbq2lb	149	18	may	may	MD
cord-267897-w4pbq2lb	149	19	reveal	reveal	VB
cord-267897-w4pbq2lb	149	20	if	if	IN
cord-267897-w4pbq2lb	149	21	single	single	JJ
cord-267897-w4pbq2lb	149	22	components	component	NNS
cord-267897-w4pbq2lb	149	23	from	from	IN
cord-267897-w4pbq2lb	149	24	the	the	DT
cord-267897-w4pbq2lb	149	25	complex	complex	JJ
cord-267897-w4pbq2lb	149	26	solution	solution	NN
cord-267897-w4pbq2lb	149	27	of	of	IN
cord-267897-w4pbq2lb	149	28	proteins	protein	NNS
cord-267897-w4pbq2lb	149	29	remain	remain	VBP
cord-267897-w4pbq2lb	149	30	unadsorbed	unadsorbed	JJ
cord-267897-w4pbq2lb	149	31	.	.	.
cord-267897-w4pbq2lb	150	1	To	to	TO
cord-267897-w4pbq2lb	150	2	use	use	VB
cord-267897-w4pbq2lb	150	3	this	this	DT
cord-267897-w4pbq2lb	150	4	approach	approach	NN
cord-267897-w4pbq2lb	150	5	,	,	,
cord-267897-w4pbq2lb	150	6	the	the	DT
cord-267897-w4pbq2lb	150	7	precipitation	precipitation	NN
cord-267897-w4pbq2lb	150	8	band	band	NN
cord-267897-w4pbq2lb	150	9	pattern	pattern	NN
cord-267897-w4pbq2lb	150	10	from	from	IN
cord-267897-w4pbq2lb	150	11	an	an	DT
cord-267897-w4pbq2lb	150	12	electrophoresis	electrophoresis	NN
cord-267897-w4pbq2lb	150	13	run	run	NN
cord-267897-w4pbq2lb	150	14	on	on	IN
cord-267897-w4pbq2lb	150	15	the	the	DT
cord-267897-w4pbq2lb	150	16	complex	complex	JJ
cord-267897-w4pbq2lb	150	17	antigen	antigen	NN
cord-267897-w4pbq2lb	150	18	mixture	mixture	NN
cord-267897-w4pbq2lb	150	19	prior	prior	RB
cord-267897-w4pbq2lb	150	20	to	to	IN
cord-267897-w4pbq2lb	150	21	adsorption	adsorption	NN
cord-267897-w4pbq2lb	150	22	is	be	VBZ
cord-267897-w4pbq2lb	150	23	compared	compare	VBN
cord-267897-w4pbq2lb	150	24	with	with	IN
cord-267897-w4pbq2lb	150	25	the	the	DT
cord-267897-w4pbq2lb	150	26	bands	band	NNS
cord-267897-w4pbq2lb	150	27	of	of	IN
cord-267897-w4pbq2lb	150	28	an	an	DT
cord-267897-w4pbq2lb	150	29	electrophoresis	electrophoresis	NN
cord-267897-w4pbq2lb	150	30	run	run	NN
cord-267897-w4pbq2lb	150	31	on	on	IN
cord-267897-w4pbq2lb	150	32	the	the	DT
cord-267897-w4pbq2lb	150	33	supernatant	supernatant	NN
cord-267897-w4pbq2lb	150	34	of	of	IN
cord-267897-w4pbq2lb	150	35	the	the	DT
cord-267897-w4pbq2lb	150	36	same	same	JJ
cord-267897-w4pbq2lb	150	37	mixture	mixture	NN
cord-267897-w4pbq2lb	150	38	after	after	IN
cord-267897-w4pbq2lb	150	39	adsorption	adsorption	NN
cord-267897-w4pbq2lb	150	40	.	.	.
cord-267897-w4pbq2lb	151	1	Unadsorbed	unadsorbed	JJ
cord-267897-w4pbq2lb	151	2	components	component	NNS
cord-267897-w4pbq2lb	151	3	will	will	MD
cord-267897-w4pbq2lb	151	4	retain	retain	VB
cord-267897-w4pbq2lb	151	5	their	-PRON-	PRP$
cord-267897-w4pbq2lb	151	6	immunoprecipitation	immunoprecipitation	NN
cord-267897-w4pbq2lb	151	7	band	band	NN
cord-267897-w4pbq2lb	151	8	pattern	pattern	NN
cord-267897-w4pbq2lb	151	9	,	,	,
cord-267897-w4pbq2lb	151	10	whereas	whereas	IN
cord-267897-w4pbq2lb	151	11	missing	miss	VBG
cord-267897-w4pbq2lb	151	12	bands	band	NNS
cord-267897-w4pbq2lb	151	13	or	or	CC
cord-267897-w4pbq2lb	151	14	reduced	reduce	VBN
cord-267897-w4pbq2lb	151	15	height	height	NN
cord-267897-w4pbq2lb	151	16	of	of	IN
cord-267897-w4pbq2lb	151	17	bands	band	NNS
cord-267897-w4pbq2lb	151	18	are	be	VBP
cord-267897-w4pbq2lb	151	19	indicative	indicative	JJ
cord-267897-w4pbq2lb	151	20	of	of	IN
cord-267897-w4pbq2lb	151	21	complete	complete	JJ
cord-267897-w4pbq2lb	151	22	or	or	CC
cord-267897-w4pbq2lb	151	23	partial	partial	JJ
cord-267897-w4pbq2lb	151	24	protein	protein	NN
cord-267897-w4pbq2lb	151	25	adsorption	adsorption	NN
cord-267897-w4pbq2lb	151	26	.	.	.
cord-267897-w4pbq2lb	152	1	61	61	CD
cord-267897-w4pbq2lb	153	1	An	an	DT
cord-267897-w4pbq2lb	153	2	HPLC	HPLC	NNP
cord-267897-w4pbq2lb	153	3	chromatogram	chromatogram	NN
cord-267897-w4pbq2lb	153	4	of	of	IN
cord-267897-w4pbq2lb	153	5	the	the	DT
cord-267897-w4pbq2lb	153	6	antigen	antigen	NN
cord-267897-w4pbq2lb	153	7	mixture	mixture	NN
cord-267897-w4pbq2lb	153	8	liquid	liquid	NN
cord-267897-w4pbq2lb	153	9	phase	phase	NN
cord-267897-w4pbq2lb	153	10	before	before	RB
cord-267897-w4pbq2lb	153	11	and	and	CC
cord-267897-w4pbq2lb	153	12	after	after	IN
cord-267897-w4pbq2lb	153	13	adsorption	adsorption	NN
cord-267897-w4pbq2lb	153	14	may	may	MD
cord-267897-w4pbq2lb	153	15	provide	provide	VB
cord-267897-w4pbq2lb	153	16	a	a	DT
cord-267897-w4pbq2lb	153	17	similar	similar	JJ
cord-267897-w4pbq2lb	153	18	type	type	NN
cord-267897-w4pbq2lb	153	19	of	of	IN
cord-267897-w4pbq2lb	153	20	information	information	NN
cord-267897-w4pbq2lb	153	21	.	.	.
cord-267897-w4pbq2lb	154	1	For	for	IN
cord-267897-w4pbq2lb	154	2	the	the	DT
cord-267897-w4pbq2lb	154	3	testing	testing	NN
cord-267897-w4pbq2lb	154	4	of	of	IN
cord-267897-w4pbq2lb	154	5	adsorptive	adsorptive	JJ
cord-267897-w4pbq2lb	154	6	power	power	NN
cord-267897-w4pbq2lb	154	7	of	of	IN
cord-267897-w4pbq2lb	154	8	mineral	mineral	NN
cord-267897-w4pbq2lb	154	9	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	154	10	when	when	WRB
cord-267897-w4pbq2lb	154	11	used	use	VBN
cord-267897-w4pbq2lb	154	12	in	in	IN
cord-267897-w4pbq2lb	154	13	diphtheria	diphtheria	NN
cord-267897-w4pbq2lb	154	14	and	and	CC
cord-267897-w4pbq2lb	154	15	tetanus	tetanus	NN
cord-267897-w4pbq2lb	154	16	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	154	17	,	,	,
cord-267897-w4pbq2lb	154	18	the	the	DT
cord-267897-w4pbq2lb	154	19	old	old	JJ
cord-267897-w4pbq2lb	154	20	Ramon	Ramon	NNP
cord-267897-w4pbq2lb	154	21	flocculation	flocculation	NN
cord-267897-w4pbq2lb	154	22	test	test	NN
cord-267897-w4pbq2lb	154	23	is	be	VBZ
cord-267897-w4pbq2lb	154	24	still	still	RB
cord-267897-w4pbq2lb	154	25	frequently	frequently	RB
cord-267897-w4pbq2lb	154	26	used	use	VBN
cord-267897-w4pbq2lb	154	27	.	.	.
cord-267897-w4pbq2lb	155	1	In	in	IN
cord-267897-w4pbq2lb	155	2	this	this	DT
cord-267897-w4pbq2lb	155	3	test	test	NN
cord-267897-w4pbq2lb	155	4	the	the	DT
cord-267897-w4pbq2lb	155	5	results	result	NNS
cord-267897-w4pbq2lb	155	6	are	be	VBP
cord-267897-w4pbq2lb	155	7	given	give	VBN
cord-267897-w4pbq2lb	155	8	as	as	IN
cord-267897-w4pbq2lb	155	9	Lf	Lf	NNP
cord-267897-w4pbq2lb	155	10	(	(	-LRB-
cord-267897-w4pbq2lb	155	11	limits	limit	NNS
cord-267897-w4pbq2lb	155	12	of	of	IN
cord-267897-w4pbq2lb	155	13	flocculation	flocculation	NN
cord-267897-w4pbq2lb	155	14	)	)	-RRB-
cord-267897-w4pbq2lb	155	15	.	.	.
cord-267897-w4pbq2lb	156	1	It	-PRON-	PRP
cord-267897-w4pbq2lb	156	2	is	be	VBZ
cord-267897-w4pbq2lb	156	3	of	of	IN
cord-267897-w4pbq2lb	156	4	relevance	relevance	NN
cord-267897-w4pbq2lb	156	5	to	to	TO
cord-267897-w4pbq2lb	156	6	distinguish	distinguish	VB
cord-267897-w4pbq2lb	156	7	between	between	IN
cord-267897-w4pbq2lb	156	8	the	the	DT
cord-267897-w4pbq2lb	156	9	adsorption	adsorption	NN
cord-267897-w4pbq2lb	156	10	capacity	capacity	NN
cord-267897-w4pbq2lb	156	11	,	,	,
cord-267897-w4pbq2lb	156	12	which	which	WDT
cord-267897-w4pbq2lb	156	13	is	be	VBZ
cord-267897-w4pbq2lb	156	14	the	the	DT
cord-267897-w4pbq2lb	156	15	amount	amount	NN
cord-267897-w4pbq2lb	156	16	of	of	IN
cord-267897-w4pbq2lb	156	17	antigen	antigen	NN
cord-267897-w4pbq2lb	156	18	that	that	WDT
cord-267897-w4pbq2lb	156	19	is	be	VBZ
cord-267897-w4pbq2lb	156	20	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	156	21	at	at	IN
cord-267897-w4pbq2lb	156	22	monolayer	monolayer	NN
cord-267897-w4pbq2lb	156	23	coverage	coverage	NN
cord-267897-w4pbq2lb	156	24	of	of	IN
cord-267897-w4pbq2lb	156	25	the	the	DT
cord-267897-w4pbq2lb	156	26	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	156	27	,	,	,
cord-267897-w4pbq2lb	156	28	and	and	CC
cord-267897-w4pbq2lb	156	29	the	the	DT
cord-267897-w4pbq2lb	156	30	adsorption	adsorption	NN
cord-267897-w4pbq2lb	156	31	coefficient	coefficient	NN
cord-267897-w4pbq2lb	156	32	,	,	,
cord-267897-w4pbq2lb	156	33	which	which	WDT
cord-267897-w4pbq2lb	156	34	is	be	VBZ
cord-267897-w4pbq2lb	156	35	a	a	DT
cord-267897-w4pbq2lb	156	36	measure	measure	NN
cord-267897-w4pbq2lb	156	37	of	of	IN
cord-267897-w4pbq2lb	156	38	the	the	DT
cord-267897-w4pbq2lb	156	39	strength	strength	NN
cord-267897-w4pbq2lb	156	40	of	of	IN
cord-267897-w4pbq2lb	156	41	the	the	DT
cord-267897-w4pbq2lb	156	42	adsorption	adsorption	NN
cord-267897-w4pbq2lb	156	43	force	force	NN
cord-267897-w4pbq2lb	156	44	,	,	,
cord-267897-w4pbq2lb	156	45	not	not	RB
cord-267897-w4pbq2lb	156	46	the	the	DT
cord-267897-w4pbq2lb	156	47	least	least	JJS
cord-267897-w4pbq2lb	156	48	since	since	IN
cord-267897-w4pbq2lb	156	49	there	there	EX
cord-267897-w4pbq2lb	156	50	is	be	VBZ
cord-267897-w4pbq2lb	156	51	evidence	evidence	NN
cord-267897-w4pbq2lb	156	52	that	that	IN
cord-267897-w4pbq2lb	156	53	very	very	RB
cord-267897-w4pbq2lb	156	54	high	high	JJ
cord-267897-w4pbq2lb	156	55	adsorption	adsorption	NN
cord-267897-w4pbq2lb	156	56	coefficients	coefficient	NNS
cord-267897-w4pbq2lb	156	57	may	may	MD
cord-267897-w4pbq2lb	156	58	lead	lead	VB
cord-267897-w4pbq2lb	156	59	to	to	IN
cord-267897-w4pbq2lb	156	60	reduction	reduction	NN
cord-267897-w4pbq2lb	156	61	of	of	IN
cord-267897-w4pbq2lb	156	62	the	the	DT
cord-267897-w4pbq2lb	156	63	immune	immune	JJ
cord-267897-w4pbq2lb	156	64	response	response	NN
cord-267897-w4pbq2lb	156	65	.	.	.
cord-267897-w4pbq2lb	157	1	66e68	66e68	CD
cord-267897-w4pbq2lb	157	2	Various	various	JJ
cord-267897-w4pbq2lb	157	3	mathematical	mathematical	JJ
cord-267897-w4pbq2lb	157	4	models	model	NNS
cord-267897-w4pbq2lb	157	5	can	can	MD
cord-267897-w4pbq2lb	157	6	be	be	VB
cord-267897-w4pbq2lb	157	7	used	use	VBN
cord-267897-w4pbq2lb	157	8	to	to	TO
cord-267897-w4pbq2lb	157	9	describe	describe	VB
cord-267897-w4pbq2lb	157	10	protein	protein	NN
cord-267897-w4pbq2lb	157	11	adsorption	adsorption	NN
cord-267897-w4pbq2lb	157	12	quantitatively	quantitatively	RB
cord-267897-w4pbq2lb	157	13	.	.	.
cord-267897-w4pbq2lb	158	1	Adsorption	adsorption	NN
cord-267897-w4pbq2lb	158	2	of	of	IN
cord-267897-w4pbq2lb	158	3	molecules	molecule	NNS
cord-267897-w4pbq2lb	158	4	to	to	IN
cord-267897-w4pbq2lb	158	5	surfaces	surface	NNS
cord-267897-w4pbq2lb	158	6	,	,	,
cord-267897-w4pbq2lb	158	7	like	like	IN
cord-267897-w4pbq2lb	158	8	antigens	antigen	NNS
cord-267897-w4pbq2lb	158	9	to	to	IN
cord-267897-w4pbq2lb	158	10	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	158	11	particles	particle	NNS
cord-267897-w4pbq2lb	158	12	,	,	,
cord-267897-w4pbq2lb	158	13	is	be	VBZ
cord-267897-w4pbq2lb	158	14	governed	govern	VBN
cord-267897-w4pbq2lb	158	15	by	by	IN
cord-267897-w4pbq2lb	158	16	equilibrium	equilibrium	NN
cord-267897-w4pbq2lb	158	17	thermodynamics	thermodynamic	NNS
cord-267897-w4pbq2lb	158	18	and	and	CC
cord-267897-w4pbq2lb	158	19	kinetic	kinetic	JJ
cord-267897-w4pbq2lb	158	20	principles	principle	NNS
cord-267897-w4pbq2lb	158	21	,	,	,
cord-267897-w4pbq2lb	158	22	where	where	WRB
cord-267897-w4pbq2lb	158	23	the	the	DT
cord-267897-w4pbq2lb	158	24	proportion	proportion	NN
cord-267897-w4pbq2lb	158	25	of	of	IN
cord-267897-w4pbq2lb	158	26	surface	surface	NN
cord-267897-w4pbq2lb	158	27	covered	cover	VBN
cord-267897-w4pbq2lb	158	28	by	by	IN
cord-267897-w4pbq2lb	158	29	the	the	DT
cord-267897-w4pbq2lb	158	30	adsorbate	adsorbate	NN
cord-267897-w4pbq2lb	158	31	at	at	IN
cord-267897-w4pbq2lb	158	32	equilibrium	equilibrium	NN
cord-267897-w4pbq2lb	158	33	,	,	,
cord-267897-w4pbq2lb	158	34	in	in	IN
cord-267897-w4pbq2lb	158	35	principle	principle	NN
cord-267897-w4pbq2lb	158	36	depends	depend	VBZ
cord-267897-w4pbq2lb	158	37	on	on	IN
cord-267897-w4pbq2lb	158	38	the	the	DT
cord-267897-w4pbq2lb	158	39	adsorbate	adsorbate	NN
cord-267897-w4pbq2lb	158	40	concentration	concentration	NN
cord-267897-w4pbq2lb	158	41	and	and	CC
cord-267897-w4pbq2lb	158	42	the	the	DT
cord-267897-w4pbq2lb	158	43	rate	rate	NN
cord-267897-w4pbq2lb	158	44	constants	constant	NNS
cord-267897-w4pbq2lb	158	45	for	for	IN
cord-267897-w4pbq2lb	158	46	adsorption	adsorption	NN
cord-267897-w4pbq2lb	158	47	and	and	CC
cord-267897-w4pbq2lb	158	48	desorption	desorption	NN
cord-267897-w4pbq2lb	158	49	,	,	,
cord-267897-w4pbq2lb	158	50	at	at	IN
cord-267897-w4pbq2lb	158	51	a	a	DT
cord-267897-w4pbq2lb	158	52	given	give	VBN
cord-267897-w4pbq2lb	158	53	temperature	temperature	NN
cord-267897-w4pbq2lb	158	54	and	and	CC
cord-267897-w4pbq2lb	158	55	pressure	pressure	NN
cord-267897-w4pbq2lb	158	56	.	.	.
cord-267897-w4pbq2lb	159	1	In	in	IN
cord-267897-w4pbq2lb	159	2	its	-PRON-	PRP$
cord-267897-w4pbq2lb	159	3	simplest	simple	JJS
cord-267897-w4pbq2lb	159	4	form	form	NN
cord-267897-w4pbq2lb	159	5	,	,	,
cord-267897-w4pbq2lb	159	6	this	this	DT
cord-267897-w4pbq2lb	159	7	process	process	NN
cord-267897-w4pbq2lb	159	8	is	be	VBZ
cord-267897-w4pbq2lb	159	9	described	describe	VBN
cord-267897-w4pbq2lb	159	10	by	by	IN
cord-267897-w4pbq2lb	159	11	the	the	DT
cord-267897-w4pbq2lb	159	12	Langmuir	Langmuir	NNP
cord-267897-w4pbq2lb	159	13	isotherm	isotherm	NN
cord-267897-w4pbq2lb	159	14	,	,	,
cord-267897-w4pbq2lb	159	15	69	69	CD
cord-267897-w4pbq2lb	159	16	which	which	WDT
cord-267897-w4pbq2lb	159	17	was	be	VBD
cord-267897-w4pbq2lb	159	18	originally	originally	RB
cord-267897-w4pbq2lb	159	19	derived	derive	VBN
cord-267897-w4pbq2lb	159	20	to	to	TO
cord-267897-w4pbq2lb	159	21	describe	describe	VB
cord-267897-w4pbq2lb	159	22	the	the	DT
cord-267897-w4pbq2lb	159	23	adsorption	adsorption	NN
cord-267897-w4pbq2lb	159	24	of	of	IN
cord-267897-w4pbq2lb	159	25	gas	gas	NN
cord-267897-w4pbq2lb	159	26	molecules	molecule	NNS
cord-267897-w4pbq2lb	159	27	to	to	IN
cord-267897-w4pbq2lb	159	28	simple	simple	JJ
cord-267897-w4pbq2lb	159	29	planar	planar	JJ
cord-267897-w4pbq2lb	159	30	surfaces	surface	NNS
cord-267897-w4pbq2lb	159	31	.	.	.
cord-267897-w4pbq2lb	160	1	When	when	WRB
cord-267897-w4pbq2lb	160	2	applied	apply	VBN
cord-267897-w4pbq2lb	160	3	to	to	IN
cord-267897-w4pbq2lb	160	4	the	the	DT
cord-267897-w4pbq2lb	160	5	adsorption	adsorption	NN
cord-267897-w4pbq2lb	160	6	of	of	IN
cord-267897-w4pbq2lb	160	7	molecules	molecule	NNS
cord-267897-w4pbq2lb	160	8	in	in	IN
cord-267897-w4pbq2lb	160	9	solution	solution	NN
cord-267897-w4pbq2lb	160	10	by	by	IN
cord-267897-w4pbq2lb	160	11	solid	solid	JJ
cord-267897-w4pbq2lb	160	12	interfaces	interface	NNS
cord-267897-w4pbq2lb	160	13	,	,	,
cord-267897-w4pbq2lb	160	14	the	the	DT
cord-267897-w4pbq2lb	160	15	relation	relation	NN
cord-267897-w4pbq2lb	160	16	between	between	IN
cord-267897-w4pbq2lb	160	17	the	the	DT
cord-267897-w4pbq2lb	160	18	quantity	quantity	NN
cord-267897-w4pbq2lb	160	19	of	of	IN
cord-267897-w4pbq2lb	160	20	a	a	DT
cord-267897-w4pbq2lb	160	21	solute	solute	NN
cord-267897-w4pbq2lb	160	22	molecule	molecule	NN
cord-267897-w4pbq2lb	160	23	,	,	,
cord-267897-w4pbq2lb	160	24	Q	Q	NNP
cord-267897-w4pbq2lb	160	25	,	,	,
cord-267897-w4pbq2lb	160	26	which	which	WDT
cord-267897-w4pbq2lb	160	27	is	be	VBZ
cord-267897-w4pbq2lb	160	28	bound	bind	VBN
cord-267897-w4pbq2lb	160	29	to	to	IN
cord-267897-w4pbq2lb	160	30	the	the	DT
cord-267897-w4pbq2lb	160	31	surface	surface	NN
cord-267897-w4pbq2lb	160	32	of	of	IN
cord-267897-w4pbq2lb	160	33	the	the	DT
cord-267897-w4pbq2lb	160	34	adsorbent	adsorbent	NN
cord-267897-w4pbq2lb	160	35	,	,	,
cord-267897-w4pbq2lb	160	36	and	and	CC
cord-267897-w4pbq2lb	160	37	its	-PRON-	PRP$
cord-267897-w4pbq2lb	160	38	concentration	concentration	NN
cord-267897-w4pbq2lb	160	39	[	[	-LRB-
cord-267897-w4pbq2lb	160	40	A	a	NN
cord-267897-w4pbq2lb	160	41	]	]	-RRB-
cord-267897-w4pbq2lb	160	42	is	be	VBZ
cord-267897-w4pbq2lb	160	43	given	give	VBN
cord-267897-w4pbq2lb	160	44	by	by	IN
cord-267897-w4pbq2lb	160	45	the	the	DT
cord-267897-w4pbq2lb	160	46	following	follow	VBG
cord-267897-w4pbq2lb	160	47	function	function	NN
cord-267897-w4pbq2lb	160	48	,	,	,
cord-267897-w4pbq2lb	160	49	which	which	WDT
cord-267897-w4pbq2lb	160	50	is	be	VBZ
cord-267897-w4pbq2lb	160	51	a	a	DT
cord-267897-w4pbq2lb	160	52	rectangular	rectangular	JJ
cord-267897-w4pbq2lb	160	53	hyperbola	hyperbola	NN
cord-267897-w4pbq2lb	160	54	:	:	:
cord-267897-w4pbq2lb	160	55	with	with	IN
cord-267897-w4pbq2lb	160	56	Q	Q	NNP
cord-267897-w4pbq2lb	160	57	max	max	NNP
cord-267897-w4pbq2lb	160	58	being	be	VBG
cord-267897-w4pbq2lb	160	59	the	the	DT
cord-267897-w4pbq2lb	160	60	maximal	maximal	JJ
cord-267897-w4pbq2lb	160	61	quantity	quantity	NN
cord-267897-w4pbq2lb	160	62	of	of	IN
cord-267897-w4pbq2lb	160	63	adsorbed	adsorbed	JJ
cord-267897-w4pbq2lb	160	64	molecule	molecule	NN
cord-267897-w4pbq2lb	160	65	and	and	CC
cord-267897-w4pbq2lb	160	66	K	K	NNP
cord-267897-w4pbq2lb	160	67	eq	eq	NN
cord-267897-w4pbq2lb	160	68	being	be	VBG
cord-267897-w4pbq2lb	160	69	the	the	DT
cord-267897-w4pbq2lb	160	70	equilibrium	equilibrium	NN
cord-267897-w4pbq2lb	160	71	constant	constant	JJ
cord-267897-w4pbq2lb	160	72	.	.	.
cord-267897-w4pbq2lb	161	1	This	this	DT
cord-267897-w4pbq2lb	161	2	equation	equation	NN
cord-267897-w4pbq2lb	161	3	can	can	MD
cord-267897-w4pbq2lb	161	4	also	also	RB
cord-267897-w4pbq2lb	161	5	be	be	VB
cord-267897-w4pbq2lb	161	6	written	write	VBN
cord-267897-w4pbq2lb	161	7	as	as	IN
cord-267897-w4pbq2lb	161	8	the	the	DT
cord-267897-w4pbq2lb	161	9	proportion	proportion	NN
cord-267897-w4pbq2lb	161	10	of	of	IN
cord-267897-w4pbq2lb	161	11	sites	site	NNS
cord-267897-w4pbq2lb	161	12	occupied	occupy	VBN
cord-267897-w4pbq2lb	161	13	on	on	IN
cord-267897-w4pbq2lb	161	14	the	the	DT
cord-267897-w4pbq2lb	161	15	surface	surface	NN
cord-267897-w4pbq2lb	161	16	,	,	,
cord-267897-w4pbq2lb	161	17	q	q	NNP
cord-267897-w4pbq2lb	161	18	(	(	-LRB-
cord-267897-w4pbq2lb	161	19	with	with	IN
cord-267897-w4pbq2lb	161	20	q	q	NNP
cord-267897-w4pbq2lb	161	21	¼	¼	NNP
cord-267897-w4pbq2lb	161	22	Q	Q	NNP
cord-267897-w4pbq2lb	161	23	/	/	SYM
cord-267897-w4pbq2lb	161	24	Q	Q	NNP
cord-267897-w4pbq2lb	161	25	max	max	NNP
cord-267897-w4pbq2lb	161	26	)	)	-RRB-
cord-267897-w4pbq2lb	161	27	,	,	,
cord-267897-w4pbq2lb	161	28	as	as	IN
cord-267897-w4pbq2lb	161	29	a	a	DT
cord-267897-w4pbq2lb	161	30	function	function	NN
cord-267897-w4pbq2lb	161	31	of	of	IN
cord-267897-w4pbq2lb	161	32	the	the	DT
cord-267897-w4pbq2lb	161	33	concentration	concentration	NN
cord-267897-w4pbq2lb	161	34	of	of	IN
cord-267897-w4pbq2lb	161	35	adsorbate	adsorbate	NN
cord-267897-w4pbq2lb	161	36	[	[	-LRB-
cord-267897-w4pbq2lb	161	37	A	a	NN
cord-267897-w4pbq2lb	161	38	]	]	-RRB-
cord-267897-w4pbq2lb	161	39	:	:	:
cord-267897-w4pbq2lb	162	1	The	the	DT
cord-267897-w4pbq2lb	162	2	strength	strength	NN
cord-267897-w4pbq2lb	162	3	of	of	IN
cord-267897-w4pbq2lb	162	4	this	this	DT
cord-267897-w4pbq2lb	162	5	model	model	NN
cord-267897-w4pbq2lb	162	6	,	,	,
cord-267897-w4pbq2lb	162	7	which	which	WDT
cord-267897-w4pbq2lb	162	8	makes	make	VBZ
cord-267897-w4pbq2lb	162	9	it	-PRON-	PRP
cord-267897-w4pbq2lb	162	10	popular	popular	JJ
cord-267897-w4pbq2lb	162	11	and	and	CC
cord-267897-w4pbq2lb	162	12	attractive	attractive	JJ
cord-267897-w4pbq2lb	162	13	,	,	,
cord-267897-w4pbq2lb	162	14	is	be	VBZ
cord-267897-w4pbq2lb	162	15	that	that	IN
cord-267897-w4pbq2lb	162	16	it	-PRON-	PRP
cord-267897-w4pbq2lb	162	17	is	be	VBZ
cord-267897-w4pbq2lb	162	18	based	base	VBN
cord-267897-w4pbq2lb	162	19	on	on	IN
cord-267897-w4pbq2lb	162	20	a	a	DT
cord-267897-w4pbq2lb	162	21	physical	physical	JJ
cord-267897-w4pbq2lb	162	22	theory	theory	NN
cord-267897-w4pbq2lb	162	23	and	and	CC
cord-267897-w4pbq2lb	162	24	it	-PRON-	PRP
cord-267897-w4pbq2lb	162	25	allows	allow	VBZ
cord-267897-w4pbq2lb	162	26	with	with	IN
cord-267897-w4pbq2lb	162	27	a	a	DT
cord-267897-w4pbq2lb	162	28	simple	simple	JJ
cord-267897-w4pbq2lb	162	29	data	data	NN
cord-267897-w4pbq2lb	162	30	fitting	fitting	NN
cord-267897-w4pbq2lb	162	31	procedure	procedure	NN
cord-267897-w4pbq2lb	162	32	(	(	-LRB-
cord-267897-w4pbq2lb	162	33	e.g.	e.g.	RB
cord-267897-w4pbq2lb	162	34	,	,	,
cord-267897-w4pbq2lb	162	35	nonlinear	nonlinear	JJ
cord-267897-w4pbq2lb	162	36	leastsquares	leastsquares	NNP
cord-267897-w4pbq2lb	162	37	method	method	NN
cord-267897-w4pbq2lb	162	38	)	)	-RRB-
cord-267897-w4pbq2lb	162	39	to	to	TO
cord-267897-w4pbq2lb	162	40	extract	extract	VB
cord-267897-w4pbq2lb	162	41	the	the	DT
cord-267897-w4pbq2lb	162	42	equilibrium	equilibrium	NN
cord-267897-w4pbq2lb	162	43	constant	constant	NN
cord-267897-w4pbq2lb	162	44	,	,	,
cord-267897-w4pbq2lb	162	45	which	which	WDT
cord-267897-w4pbq2lb	162	46	is	be	VBZ
cord-267897-w4pbq2lb	162	47	a	a	DT
cord-267897-w4pbq2lb	162	48	measure	measure	NN
cord-267897-w4pbq2lb	162	49	of	of	IN
cord-267897-w4pbq2lb	162	50	the	the	DT
cord-267897-w4pbq2lb	162	51	binding	binding	NN
cord-267897-w4pbq2lb	162	52	strength	strength	NN
cord-267897-w4pbq2lb	162	53	of	of	IN
cord-267897-w4pbq2lb	162	54	the	the	DT
cord-267897-w4pbq2lb	162	55	adsorbate	adsorbate	NN
cord-267897-w4pbq2lb	162	56	to	to	IN
cord-267897-w4pbq2lb	162	57	the	the	DT
cord-267897-w4pbq2lb	162	58	surface	surface	NN
cord-267897-w4pbq2lb	162	59	.	.	.
cord-267897-w4pbq2lb	163	1	However	however	RB
cord-267897-w4pbq2lb	163	2	,	,	,
cord-267897-w4pbq2lb	163	3	despite	despite	IN
cord-267897-w4pbq2lb	163	4	its	-PRON-	PRP$
cord-267897-w4pbq2lb	163	5	popularity	popularity	NN
cord-267897-w4pbq2lb	163	6	,	,	,
cord-267897-w4pbq2lb	163	7	the	the	DT
cord-267897-w4pbq2lb	163	8	Langmuir	Langmuir	NNP
cord-267897-w4pbq2lb	163	9	isotherm	isotherm	NN
cord-267897-w4pbq2lb	163	10	very	very	RB
cord-267897-w4pbq2lb	163	11	rarely	rarely	RB
cord-267897-w4pbq2lb	163	12	corresponds	correspond	VBZ
cord-267897-w4pbq2lb	163	13	to	to	IN
cord-267897-w4pbq2lb	163	14	the	the	DT
cord-267897-w4pbq2lb	163	15	physical	physical	JJ
cord-267897-w4pbq2lb	163	16	reality	reality	NN
cord-267897-w4pbq2lb	163	17	of	of	IN
cord-267897-w4pbq2lb	163	18	macromolecule	macromolecule	NN
cord-267897-w4pbq2lb	163	19	adsorption	adsorption	NN
cord-267897-w4pbq2lb	163	20	to	to	IN
cord-267897-w4pbq2lb	163	21	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	163	22	surfaces	surface	NNS
cord-267897-w4pbq2lb	163	23	,	,	,
cord-267897-w4pbq2lb	163	24	as	as	IN
cord-267897-w4pbq2lb	163	25	most	most	JJS
cord-267897-w4pbq2lb	163	26	of	of	IN
cord-267897-w4pbq2lb	163	27	the	the	DT
cord-267897-w4pbq2lb	163	28	underlying	underlie	VBG
cord-267897-w4pbq2lb	163	29	assumptions	assumption	NNS
cord-267897-w4pbq2lb	163	30	are	be	VBP
cord-267897-w4pbq2lb	163	31	generally	generally	RB
cord-267897-w4pbq2lb	163	32	violated	violate	VBN
cord-267897-w4pbq2lb	163	33	(	(	-LRB-
cord-267897-w4pbq2lb	163	34	homogeneous	homogeneous	JJ
cord-267897-w4pbq2lb	163	35	and	and	CC
cord-267897-w4pbq2lb	163	36	1:1	1:1	JJ
cord-267897-w4pbq2lb	163	37	binding	bind	VBG
cord-267897-w4pbq2lb	163	38	sites	site	NNS
cord-267897-w4pbq2lb	163	39	,	,	,
cord-267897-w4pbq2lb	163	40	dynamic	dynamic	JJ
cord-267897-w4pbq2lb	163	41	equilibrium	equilibrium	NN
cord-267897-w4pbq2lb	163	42	at	at	IN
cord-267897-w4pbq2lb	163	43	time	time	NN
cord-267897-w4pbq2lb	163	44	of	of	IN
cord-267897-w4pbq2lb	163	45	measurement	measurement	NN
cord-267897-w4pbq2lb	163	46	.	.	.
cord-267897-w4pbq2lb	164	1	and	and	CC
cord-267897-w4pbq2lb	164	2	no	no	DT
cord-267897-w4pbq2lb	164	3	interactions	interaction	NNS
cord-267897-w4pbq2lb	164	4	between	between	IN
cord-267897-w4pbq2lb	164	5	adsorbates	adsorbate	NNS
cord-267897-w4pbq2lb	164	6	)	)	-RRB-
cord-267897-w4pbq2lb	164	7	.	.	.
cord-267897-w4pbq2lb	165	1	This	this	DT
cord-267897-w4pbq2lb	165	2	is	be	VBZ
cord-267897-w4pbq2lb	165	3	due	due	JJ
cord-267897-w4pbq2lb	165	4	to	to	IN
cord-267897-w4pbq2lb	165	5	the	the	DT
cord-267897-w4pbq2lb	165	6	complex	complex	JJ
cord-267897-w4pbq2lb	165	7	nature	nature	NN
cord-267897-w4pbq2lb	165	8	of	of	IN
cord-267897-w4pbq2lb	165	9	macromolecule	macromolecule	NN
cord-267897-w4pbq2lb	165	10	(	(	-LRB-
cord-267897-w4pbq2lb	165	11	protein	protein	NN
cord-267897-w4pbq2lb	165	12	antigen	antigen	NN
cord-267897-w4pbq2lb	165	13	)	)	-RRB-
cord-267897-w4pbq2lb	165	14	interactions	interaction	NNS
cord-267897-w4pbq2lb	165	15	with	with	IN
cord-267897-w4pbq2lb	165	16	surfaces	surface	NNS
cord-267897-w4pbq2lb	165	17	,	,	,
cord-267897-w4pbq2lb	165	18	which	which	WDT
cord-267897-w4pbq2lb	165	19	are	be	VBP
cord-267897-w4pbq2lb	165	20	typically	typically	RB
cord-267897-w4pbq2lb	165	21	rough	rough	JJ
cord-267897-w4pbq2lb	165	22	and	and	CC
cord-267897-w4pbq2lb	165	23	inhomogeneous	inhomogeneous	JJ
cord-267897-w4pbq2lb	165	24	;	;	:
cord-267897-w4pbq2lb	165	25	the	the	DT
cord-267897-w4pbq2lb	165	26	equilibria	equilibrium	NNS
cord-267897-w4pbq2lb	165	27	conditions	condition	NNS
cord-267897-w4pbq2lb	165	28	,	,	,
cord-267897-w4pbq2lb	165	29	which	which	WDT
cord-267897-w4pbq2lb	165	30	might	may	MD
cord-267897-w4pbq2lb	165	31	not	not	RB
cord-267897-w4pbq2lb	165	32	be	be	VB
cord-267897-w4pbq2lb	165	33	achieved	achieve	VBN
cord-267897-w4pbq2lb	165	34	at	at	IN
cord-267897-w4pbq2lb	165	35	the	the	DT
cord-267897-w4pbq2lb	165	36	time	time	NN
cord-267897-w4pbq2lb	165	37	of	of	IN
cord-267897-w4pbq2lb	165	38	recording	recording	NN
cord-267897-w4pbq2lb	165	39	;	;	:
cord-267897-w4pbq2lb	165	40	the	the	DT
cord-267897-w4pbq2lb	165	41	disparity	disparity	NN
cord-267897-w4pbq2lb	165	42	and	and	CC
cord-267897-w4pbq2lb	165	43	multivalent	multivalent	JJ
cord-267897-w4pbq2lb	165	44	nature	nature	NN
cord-267897-w4pbq2lb	165	45	of	of	IN
cord-267897-w4pbq2lb	165	46	protein	protein	NN
cord-267897-w4pbq2lb	165	47	-	-	HYPH
cord-267897-w4pbq2lb	165	48	binding	bind	VBG
cord-267897-w4pbq2lb	165	49	sites	site	NNS
cord-267897-w4pbq2lb	165	50	at	at	IN
cord-267897-w4pbq2lb	165	51	their	-PRON-	PRP$
cord-267897-w4pbq2lb	165	52	own	own	JJ
cord-267897-w4pbq2lb	165	53	surface	surface	NN
cord-267897-w4pbq2lb	165	54	;	;	:
cord-267897-w4pbq2lb	165	55	structure	structure	NN
cord-267897-w4pbq2lb	165	56	remodeling	remodeling	NN
cord-267897-w4pbq2lb	165	57	upon	upon	IN
cord-267897-w4pbq2lb	165	58	adsorption	adsorption	NN
cord-267897-w4pbq2lb	165	59	;	;	:
cord-267897-w4pbq2lb	165	60	proteineprotein	proteineprotein	NNP
cord-267897-w4pbq2lb	165	61	interactions	interaction	NNS
cord-267897-w4pbq2lb	165	62	at	at	IN
cord-267897-w4pbq2lb	165	63	high	high	JJ
cord-267897-w4pbq2lb	165	64	concentrations	concentration	NNS
cord-267897-w4pbq2lb	165	65	;	;	,
cord-267897-w4pbq2lb	165	66	etc	etc	FW
cord-267897-w4pbq2lb	165	67	.	.	.
cord-267897-w4pbq2lb	166	1	This	this	DT
cord-267897-w4pbq2lb	166	2	topic	topic	NN
cord-267897-w4pbq2lb	166	3	is	be	VBZ
cord-267897-w4pbq2lb	166	4	not	not	RB
cord-267897-w4pbq2lb	166	5	discussed	discuss	VBN
cord-267897-w4pbq2lb	166	6	further	further	RB
cord-267897-w4pbq2lb	166	7	here	here	RB
cord-267897-w4pbq2lb	166	8	,	,	,
cord-267897-w4pbq2lb	166	9	and	and	CC
cord-267897-w4pbq2lb	166	10	the	the	DT
cord-267897-w4pbq2lb	166	11	reader	reader	NN
cord-267897-w4pbq2lb	166	12	is	be	VBZ
cord-267897-w4pbq2lb	166	13	referred	refer	VBN
cord-267897-w4pbq2lb	166	14	to	to	IN
cord-267897-w4pbq2lb	166	15	the	the	DT
cord-267897-w4pbq2lb	166	16	work	work	NN
cord-267897-w4pbq2lb	166	17	by	by	IN
cord-267897-w4pbq2lb	166	18	Latour	Latour	NNP
cord-267897-w4pbq2lb	166	19	.	.	.
cord-267897-w4pbq2lb	167	1	70	70	CD
cord-267897-w4pbq2lb	168	1	When	when	WRB
cord-267897-w4pbq2lb	168	2	Langmuir	Langmuir	NNP
cord-267897-w4pbq2lb	168	3	isotherms	isotherm	NNS
cord-267897-w4pbq2lb	168	4	are	be	VBP
cord-267897-w4pbq2lb	168	5	fitted	fit	VBN
cord-267897-w4pbq2lb	168	6	to	to	IN
cord-267897-w4pbq2lb	168	7	"	"	``
cord-267897-w4pbq2lb	168	8	Langmuir	Langmuir	NNP
cord-267897-w4pbq2lb	168	9	-	-	HYPH
cord-267897-w4pbq2lb	168	10	looking	look	VBG
cord-267897-w4pbq2lb	168	11	"	"	''
cord-267897-w4pbq2lb	168	12	data	datum	NNS
cord-267897-w4pbq2lb	168	13	plots	plot	NNS
cord-267897-w4pbq2lb	168	14	,	,	,
cord-267897-w4pbq2lb	168	15	there	there	EX
cord-267897-w4pbq2lb	168	16	is	be	VBZ
cord-267897-w4pbq2lb	168	17	often	often	RB
cord-267897-w4pbq2lb	168	18	the	the	DT
cord-267897-w4pbq2lb	168	19	risk	risk	NN
cord-267897-w4pbq2lb	168	20	of	of	IN
cord-267897-w4pbq2lb	168	21	underevaluating	underevaluate	VBG
cord-267897-w4pbq2lb	168	22	the	the	DT
cord-267897-w4pbq2lb	168	23	K	k	NN
cord-267897-w4pbq2lb	168	24	eq	eq	NN
cord-267897-w4pbq2lb	168	25	parameter	parameter	NN
cord-267897-w4pbq2lb	168	26	(	(	-LRB-
cord-267897-w4pbq2lb	168	27	and	and	CC
cord-267897-w4pbq2lb	168	28	associated	associate	VBD
cord-267897-w4pbq2lb	168	29	free	free	JJ
cord-267897-w4pbq2lb	168	30	Gibbs	Gibbs	NNP
cord-267897-w4pbq2lb	168	31	energy	energy	NN
cord-267897-w4pbq2lb	168	32	value	value	NN
cord-267897-w4pbq2lb	168	33	)	)	-RRB-
cord-267897-w4pbq2lb	168	34	with	with	IN
cord-267897-w4pbq2lb	168	35	the	the	DT
cord-267897-w4pbq2lb	168	36	potential	potential	NN
cord-267897-w4pbq2lb	168	37	for	for	IN
cord-267897-w4pbq2lb	168	38	drawing	draw	VBG
cord-267897-w4pbq2lb	168	39	erroneous	erroneous	JJ
cord-267897-w4pbq2lb	168	40	conclusions	conclusion	NNS
cord-267897-w4pbq2lb	168	41	.	.	.
cord-267897-w4pbq2lb	169	1	70	70	CD
cord-267897-w4pbq2lb	170	1	In	in	IN
cord-267897-w4pbq2lb	170	2	addition	addition	NN
cord-267897-w4pbq2lb	170	3	,	,	,
cord-267897-w4pbq2lb	170	4	when	when	WRB
cord-267897-w4pbq2lb	170	5	K	K	NNP
cord-267897-w4pbq2lb	170	6	eq	eq	NN
cord-267897-w4pbq2lb	170	7	values	value	NNS
cord-267897-w4pbq2lb	170	8	are	be	VBP
cord-267897-w4pbq2lb	170	9	very	very	RB
cord-267897-w4pbq2lb	170	10	high	high	JJ
cord-267897-w4pbq2lb	170	11	and	and	CC
cord-267897-w4pbq2lb	170	12	because	because	IN
cord-267897-w4pbq2lb	170	13	of	of	IN
cord-267897-w4pbq2lb	170	14	the	the	DT
cord-267897-w4pbq2lb	170	15	shape	shape	NN
cord-267897-w4pbq2lb	170	16	of	of	IN
cord-267897-w4pbq2lb	170	17	rectangular	rectangular	JJ
cord-267897-w4pbq2lb	170	18	hyperbola	hyperbola	NN
cord-267897-w4pbq2lb	170	19	,	,	,
cord-267897-w4pbq2lb	170	20	the	the	DT
cord-267897-w4pbq2lb	170	21	dynamic	dynamic	JJ
cord-267897-w4pbq2lb	170	22	range	range	NN
cord-267897-w4pbq2lb	170	23	for	for	IN
cord-267897-w4pbq2lb	170	24	data	data	NN
cord-267897-w4pbq2lb	170	25	point	point	NN
cord-267897-w4pbq2lb	170	26	collection	collection	NN
cord-267897-w4pbq2lb	170	27	can	can	MD
cord-267897-w4pbq2lb	170	28	become	become	VB
cord-267897-w4pbq2lb	170	29	compressed	compressed	JJ
cord-267897-w4pbq2lb	170	30	,	,	,
cord-267897-w4pbq2lb	170	31	making	make	VBG
cord-267897-w4pbq2lb	170	32	the	the	DT
cord-267897-w4pbq2lb	170	33	effective	effective	JJ
cord-267897-w4pbq2lb	170	34	concentration	concentration	NN
cord-267897-w4pbq2lb	170	35	range	range	NN
cord-267897-w4pbq2lb	170	36	very	very	RB
cord-267897-w4pbq2lb	170	37	limited	limited	JJ
cord-267897-w4pbq2lb	170	38	and	and	CC
cord-267897-w4pbq2lb	170	39	experimentally	experimentally	RB
cord-267897-w4pbq2lb	170	40	impractical	impractical	JJ
cord-267897-w4pbq2lb	170	41	to	to	TO
cord-267897-w4pbq2lb	170	42	handle	handle	VB
cord-267897-w4pbq2lb	170	43	.	.	.
cord-267897-w4pbq2lb	171	1	In	in	IN
cord-267897-w4pbq2lb	171	2	order	order	NN
cord-267897-w4pbq2lb	171	3	to	to	TO
cord-267897-w4pbq2lb	171	4	correct	correct	VB
cord-267897-w4pbq2lb	171	5	for	for	IN
cord-267897-w4pbq2lb	171	6	the	the	DT
cord-267897-w4pbq2lb	171	7	limitations	limitation	NNS
cord-267897-w4pbq2lb	171	8	of	of	IN
cord-267897-w4pbq2lb	171	9	the	the	DT
cord-267897-w4pbq2lb	171	10	Langmuir	Langmuir	NNP
cord-267897-w4pbq2lb	171	11	isotherm	isotherm	NN
cord-267897-w4pbq2lb	171	12	,	,	,
cord-267897-w4pbq2lb	171	13	other	other	JJ
cord-267897-w4pbq2lb	171	14	models	model	NNS
cord-267897-w4pbq2lb	171	15	were	be	VBD
cord-267897-w4pbq2lb	171	16	later	later	RB
cord-267897-w4pbq2lb	171	17	developed	develop	VBN
cord-267897-w4pbq2lb	171	18	,	,	,
cord-267897-w4pbq2lb	171	19	which	which	WDT
cord-267897-w4pbq2lb	171	20	are	be	VBP
cord-267897-w4pbq2lb	171	21	better	well	RBR
cord-267897-w4pbq2lb	171	22	suited	suited	JJ
cord-267897-w4pbq2lb	171	23	to	to	TO
cord-267897-w4pbq2lb	171	24	fit	fit	VB
cord-267897-w4pbq2lb	171	25	data	datum	NNS
cord-267897-w4pbq2lb	171	26	from	from	IN
cord-267897-w4pbq2lb	171	27	heterogeneous	heterogeneous	JJ
cord-267897-w4pbq2lb	171	28	systems	system	NNS
cord-267897-w4pbq2lb	171	29	.	.	.
cord-267897-w4pbq2lb	172	1	Hybrid	hybrid	NN
cord-267897-w4pbq2lb	172	2	models	model	NNS
cord-267897-w4pbq2lb	172	3	combining	combine	VBG
cord-267897-w4pbq2lb	172	4	the	the	DT
cord-267897-w4pbq2lb	172	5	Langmuir	Langmuir	NNP
cord-267897-w4pbq2lb	172	6	and	and	CC
cord-267897-w4pbq2lb	172	7	the	the	DT
cord-267897-w4pbq2lb	172	8	Freundlich	Freundlich	NNP
cord-267897-w4pbq2lb	172	9	isotherms	isotherm	NNS
cord-267897-w4pbq2lb	172	10	,	,	,
cord-267897-w4pbq2lb	172	11	71	71	CD
cord-267897-w4pbq2lb	172	12	such	such	JJ
cord-267897-w4pbq2lb	172	13	as	as	IN
cord-267897-w4pbq2lb	172	14	the	the	DT
cord-267897-w4pbq2lb	172	15	Toth	Toth	NNP
cord-267897-w4pbq2lb	172	16	isotherm	isotherm	NN
cord-267897-w4pbq2lb	172	17	,	,	,
cord-267897-w4pbq2lb	172	18	72	72	CD
cord-267897-w4pbq2lb	172	19	better	well	JJR
cord-267897-w4pbq2lb	172	20	satisfy	satisfy	VB
cord-267897-w4pbq2lb	172	21	the	the	DT
cord-267897-w4pbq2lb	172	22	lower	low	JJR
cord-267897-w4pbq2lb	172	23	and	and	CC
cord-267897-w4pbq2lb	172	24	upper	upper	JJ
cord-267897-w4pbq2lb	172	25	ranges	range	NNS
cord-267897-w4pbq2lb	172	26	of	of	IN
cord-267897-w4pbq2lb	172	27	adsorbate	adsorbate	NN
cord-267897-w4pbq2lb	172	28	concentrations	concentration	NNS
cord-267897-w4pbq2lb	172	29	than	than	IN
cord-267897-w4pbq2lb	172	30	any	any	DT
cord-267897-w4pbq2lb	172	31	the	the	DT
cord-267897-w4pbq2lb	172	32	two	two	CD
cord-267897-w4pbq2lb	172	33	models	model	NNS
cord-267897-w4pbq2lb	172	34	that	that	IN
cord-267897-w4pbq2lb	172	35	it	-PRON-	PRP
cord-267897-w4pbq2lb	172	36	is	be	VBZ
cord-267897-w4pbq2lb	172	37	derived	derive	VBN
cord-267897-w4pbq2lb	172	38	from	from	IN
cord-267897-w4pbq2lb	172	39	.	.	.
cord-267897-w4pbq2lb	173	1	For	for	IN
cord-267897-w4pbq2lb	173	2	a	a	DT
cord-267897-w4pbq2lb	173	3	short	short	JJ
cord-267897-w4pbq2lb	173	4	and	and	CC
cord-267897-w4pbq2lb	173	5	exhaustive	exhaustive	JJ
cord-267897-w4pbq2lb	173	6	review	review	NN
cord-267897-w4pbq2lb	173	7	of	of	IN
cord-267897-w4pbq2lb	173	8	adsorption	adsorption	NN
cord-267897-w4pbq2lb	173	9	isotherms	isotherm	NNS
cord-267897-w4pbq2lb	173	10	,	,	,
cord-267897-w4pbq2lb	173	11	see	see	VB
cord-267897-w4pbq2lb	173	12	Foo	Foo	NNP
cord-267897-w4pbq2lb	173	13	and	and	CC
cord-267897-w4pbq2lb	173	14	Hameed	Hameed	NNP
cord-267897-w4pbq2lb	173	15	.	.	.
cord-267897-w4pbq2lb	174	1	73	73	CD
cord-267897-w4pbq2lb	175	1	The	the	DT
cord-267897-w4pbq2lb	175	2	Toth	Toth	NNP
cord-267897-w4pbq2lb	175	3	equation	equation	NN
cord-267897-w4pbq2lb	175	4	takes	take	VBZ
cord-267897-w4pbq2lb	175	5	the	the	DT
cord-267897-w4pbq2lb	175	6	following	follow	VBG
cord-267897-w4pbq2lb	175	7	form	form	NN
cord-267897-w4pbq2lb	175	8	:	:	:
cord-267897-w4pbq2lb	175	9	As	as	IN
cord-267897-w4pbq2lb	175	10	seen	see	VBN
cord-267897-w4pbq2lb	175	11	,	,	,
cord-267897-w4pbq2lb	175	12	the	the	DT
cord-267897-w4pbq2lb	175	13	equation	equation	NN
cord-267897-w4pbq2lb	175	14	includes	include	VBZ
cord-267897-w4pbq2lb	175	15	an	an	DT
cord-267897-w4pbq2lb	175	16	additional	additional	JJ
cord-267897-w4pbq2lb	175	17	parameter	parameter	NN
cord-267897-w4pbq2lb	175	18	,	,	,
cord-267897-w4pbq2lb	175	19	t	t	NN
cord-267897-w4pbq2lb	175	20	,	,	,
cord-267897-w4pbq2lb	175	21	which	which	WDT
cord-267897-w4pbq2lb	175	22	when	when	WRB
cord-267897-w4pbq2lb	175	23	t	t	NNP
cord-267897-w4pbq2lb	175	24	¼	¼	NNP
cord-267897-w4pbq2lb	175	25	1	1	CD
cord-267897-w4pbq2lb	175	26	reduces	reduce	VBZ
cord-267897-w4pbq2lb	175	27	to	to	IN
cord-267897-w4pbq2lb	175	28	the	the	DT
cord-267897-w4pbq2lb	175	29	Langmuir	Langmuir	NNP
cord-267897-w4pbq2lb	175	30	equation	equation	NN
cord-267897-w4pbq2lb	175	31	.	.	.
cord-267897-w4pbq2lb	176	1	This	this	DT
cord-267897-w4pbq2lb	176	2	parameter	parameter	NN
cord-267897-w4pbq2lb	176	3	t	t	NN
cord-267897-w4pbq2lb	176	4	quantifies	quantify	VBZ
cord-267897-w4pbq2lb	176	5	the	the	DT
cord-267897-w4pbq2lb	176	6	deviation	deviation	NN
cord-267897-w4pbq2lb	176	7	from	from	IN
cord-267897-w4pbq2lb	176	8	the	the	DT
cord-267897-w4pbq2lb	176	9	ideal	ideal	JJ
cord-267897-w4pbq2lb	176	10	system	system	NN
cord-267897-w4pbq2lb	176	11	formulated	formulate	VBN
cord-267897-w4pbq2lb	176	12	by	by	IN
cord-267897-w4pbq2lb	176	13	Langmuir	Langmuir	NNP
cord-267897-w4pbq2lb	176	14	and	and	CC
cord-267897-w4pbq2lb	176	15	can	can	MD
cord-267897-w4pbq2lb	176	16	indicate	indicate	VB
cord-267897-w4pbq2lb	176	17	the	the	DT
cord-267897-w4pbq2lb	176	18	level	level	NN
cord-267897-w4pbq2lb	176	19	of	of	IN
cord-267897-w4pbq2lb	176	20	heterogeneity	heterogeneity	NN
cord-267897-w4pbq2lb	176	21	in	in	IN
cord-267897-w4pbq2lb	176	22	the	the	DT
cord-267897-w4pbq2lb	176	23	adsorption	adsorption	NN
cord-267897-w4pbq2lb	176	24	process	process	NN
cord-267897-w4pbq2lb	176	25	.	.	.
cord-267897-w4pbq2lb	177	1	72	72	CD
cord-267897-w4pbq2lb	178	1	A	a	DT
cord-267897-w4pbq2lb	178	2	typical	typical	JJ
cord-267897-w4pbq2lb	178	3	experiment	experiment	NN
cord-267897-w4pbq2lb	178	4	would	would	MD
cord-267897-w4pbq2lb	178	5	consist	consist	VB
cord-267897-w4pbq2lb	178	6	in	in	IN
cord-267897-w4pbq2lb	178	7	measuring	measure	VBG
cord-267897-w4pbq2lb	178	8	the	the	DT
cord-267897-w4pbq2lb	178	9	amount	amount	NN
cord-267897-w4pbq2lb	178	10	of	of	IN
cord-267897-w4pbq2lb	178	11	molecules	molecule	NNS
cord-267897-w4pbq2lb	178	12	bound	bind	VBN
cord-267897-w4pbq2lb	178	13	to	to	IN
cord-267897-w4pbq2lb	178	14	the	the	DT
cord-267897-w4pbq2lb	178	15	surface	surface	NN
cord-267897-w4pbq2lb	178	16	of	of	IN
cord-267897-w4pbq2lb	178	17	the	the	DT
cord-267897-w4pbq2lb	178	18	adsorbent	adsorbent	NN
cord-267897-w4pbq2lb	178	19	as	as	IN
cord-267897-w4pbq2lb	178	20	a	a	DT
cord-267897-w4pbq2lb	178	21	function	function	NN
cord-267897-w4pbq2lb	178	22	of	of	IN
cord-267897-w4pbq2lb	178	23	adsorbate	adsorbate	NN
cord-267897-w4pbq2lb	178	24	concentration	concentration	NN
cord-267897-w4pbq2lb	178	25	using	use	VBG
cord-267897-w4pbq2lb	178	26	various	various	JJ
cord-267897-w4pbq2lb	178	27	techniques	technique	NNS
cord-267897-w4pbq2lb	178	28	,	,	,
cord-267897-w4pbq2lb	178	29	and	and	CC
cord-267897-w4pbq2lb	178	30	until	until	IN
cord-267897-w4pbq2lb	178	31	the	the	DT
cord-267897-w4pbq2lb	178	32	saturation	saturation	NN
cord-267897-w4pbq2lb	178	33	of	of	IN
cord-267897-w4pbq2lb	178	34	the	the	DT
cord-267897-w4pbq2lb	178	35	surface	surface	NN
cord-267897-w4pbq2lb	178	36	is	be	VBZ
cord-267897-w4pbq2lb	178	37	achieved	achieve	VBN
cord-267897-w4pbq2lb	178	38	.	.	.
cord-267897-w4pbq2lb	179	1	In	in	IN
cord-267897-w4pbq2lb	179	2	the	the	DT
cord-267897-w4pbq2lb	179	3	case	case	NN
cord-267897-w4pbq2lb	179	4	of	of	IN
cord-267897-w4pbq2lb	179	5	insoluble	insoluble	JJ
cord-267897-w4pbq2lb	179	6	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	179	7	particles	particle	NNS
cord-267897-w4pbq2lb	179	8	,	,	,
cord-267897-w4pbq2lb	179	9	like	like	IN
cord-267897-w4pbq2lb	179	10	aluminum	aluminum	NN
cord-267897-w4pbq2lb	179	11	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	179	12	,	,	,
cord-267897-w4pbq2lb	179	13	aluminum	aluminum	NN
cord-267897-w4pbq2lb	179	14	phosphate	phosphate	NN
cord-267897-w4pbq2lb	179	15	,	,	,
cord-267897-w4pbq2lb	179	16	or	or	CC
cord-267897-w4pbq2lb	179	17	calcium	calcium	NN
cord-267897-w4pbq2lb	179	18	phosphate	phosphate	NN
cord-267897-w4pbq2lb	179	19	,	,	,
cord-267897-w4pbq2lb	179	20	the	the	DT
cord-267897-w4pbq2lb	179	21	amount	amount	NN
cord-267897-w4pbq2lb	179	22	of	of	IN
cord-267897-w4pbq2lb	179	23	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	179	24	antigen	antigen	NN
cord-267897-w4pbq2lb	179	25	can	can	MD
cord-267897-w4pbq2lb	179	26	be	be	VB
cord-267897-w4pbq2lb	179	27	measured	measure	VBN
cord-267897-w4pbq2lb	179	28	indirectly	indirectly	RB
cord-267897-w4pbq2lb	179	29	by	by	IN
cord-267897-w4pbq2lb	179	30	the	the	DT
cord-267897-w4pbq2lb	179	31	difference	difference	NN
cord-267897-w4pbq2lb	179	32	between	between	IN
cord-267897-w4pbq2lb	179	33	the	the	DT
cord-267897-w4pbq2lb	179	34	initial	initial	JJ
cord-267897-w4pbq2lb	179	35	concentration	concentration	NN
cord-267897-w4pbq2lb	179	36	in	in	IN
cord-267897-w4pbq2lb	179	37	the	the	DT
cord-267897-w4pbq2lb	179	38	solution	solution	NN
cord-267897-w4pbq2lb	179	39	and	and	CC
cord-267897-w4pbq2lb	179	40	the	the	DT
cord-267897-w4pbq2lb	179	41	final	final	JJ
cord-267897-w4pbq2lb	179	42	concentration	concentration	NN
cord-267897-w4pbq2lb	179	43	(	(	-LRB-
cord-267897-w4pbq2lb	179	44	at	at	IN
cord-267897-w4pbq2lb	179	45	equilibrium	equilibrium	NN
cord-267897-w4pbq2lb	179	46	)	)	-RRB-
cord-267897-w4pbq2lb	179	47	after	after	IN
cord-267897-w4pbq2lb	179	48	physical	physical	JJ
cord-267897-w4pbq2lb	179	49	separation	separation	NN
cord-267897-w4pbq2lb	179	50	of	of	IN
cord-267897-w4pbq2lb	179	51	the	the	DT
cord-267897-w4pbq2lb	179	52	insoluble	insoluble	JJ
cord-267897-w4pbq2lb	179	53	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	179	54	(	(	-LRB-
cord-267897-w4pbq2lb	179	55	e.g.	e.g.	RB
cord-267897-w4pbq2lb	179	56	,	,	,
cord-267897-w4pbq2lb	179	57	after	after	IN
cord-267897-w4pbq2lb	179	58	sedimentation	sedimentation	NN
cord-267897-w4pbq2lb	179	59	or	or	CC
cord-267897-w4pbq2lb	179	60	filtration	filtration	NN
cord-267897-w4pbq2lb	179	61	)	)	-RRB-
cord-267897-w4pbq2lb	179	62	.	.	.
cord-267897-w4pbq2lb	180	1	The	the	DT
cord-267897-w4pbq2lb	180	2	amount	amount	NN
cord-267897-w4pbq2lb	180	3	of	of	IN
cord-267897-w4pbq2lb	180	4	bound	bind	VBN
cord-267897-w4pbq2lb	180	5	adsorbate	adsorbate	NN
cord-267897-w4pbq2lb	180	6	is	be	VBZ
cord-267897-w4pbq2lb	180	7	plotted	plot	VBN
cord-267897-w4pbq2lb	180	8	as	as	IN
cord-267897-w4pbq2lb	180	9	a	a	DT
cord-267897-w4pbq2lb	180	10	function	function	NN
cord-267897-w4pbq2lb	180	11	of	of	IN
cord-267897-w4pbq2lb	180	12	adsorbate	adsorbate	NN
cord-267897-w4pbq2lb	180	13	concentration	concentration	NN
cord-267897-w4pbq2lb	180	14	.	.	.
cord-267897-w4pbq2lb	181	1	A	a	DT
cord-267897-w4pbq2lb	181	2	typical	typical	JJ
cord-267897-w4pbq2lb	181	3	example	example	NN
cord-267897-w4pbq2lb	181	4	of	of	IN
cord-267897-w4pbq2lb	181	5	such	such	PDT
cord-267897-w4pbq2lb	181	6	an	an	DT
cord-267897-w4pbq2lb	181	7	equilibrium	equilibrium	NN
cord-267897-w4pbq2lb	181	8	fractional	fractional	JJ
cord-267897-w4pbq2lb	181	9	saturation	saturation	NN
cord-267897-w4pbq2lb	181	10	is	be	VBZ
cord-267897-w4pbq2lb	181	11	given	give	VBN
cord-267897-w4pbq2lb	181	12	in	in	IN
cord-267897-w4pbq2lb	181	13	Fig	Fig	NNP
cord-267897-w4pbq2lb	181	14	.	.	.
cord-267897-w4pbq2lb	182	1	18	18	CD
cord-267897-w4pbq2lb	182	2	.4	.4	CD
cord-267897-w4pbq2lb	182	3	,	,	,
cord-267897-w4pbq2lb	182	4	where	where	WRB
cord-267897-w4pbq2lb	182	5	lysozyme	lysozyme	NNS
cord-267897-w4pbq2lb	182	6	was	be	VBD
cord-267897-w4pbq2lb	182	7	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	182	8	to	to	IN
cord-267897-w4pbq2lb	182	9	Adju	Adju	NNP
cord-267897-w4pbq2lb	182	10	-	-	HYPH
cord-267897-w4pbq2lb	182	11	Phos	Phos	NNP
cord-267897-w4pbq2lb	182	12	particles	particle	NNS
cord-267897-w4pbq2lb	182	13	.	.	.
cord-267897-w4pbq2lb	183	1	The	the	DT
cord-267897-w4pbq2lb	183	2	data	datum	NNS
cord-267897-w4pbq2lb	183	3	are	be	VBP
cord-267897-w4pbq2lb	183	4	fitted	fit	VBN
cord-267897-w4pbq2lb	183	5	with	with	IN
cord-267897-w4pbq2lb	183	6	the	the	DT
cord-267897-w4pbq2lb	183	7	model	model	NN
cord-267897-w4pbq2lb	183	8	isotherm	isotherm	NN
cord-267897-w4pbq2lb	183	9	,	,	,
cord-267897-w4pbq2lb	183	10	here	here	RB
cord-267897-w4pbq2lb	183	11	Langmuir	Langmuir	NNP
cord-267897-w4pbq2lb	183	12	and	and	CC
cord-267897-w4pbq2lb	183	13	Toth	Toth	NNP
cord-267897-w4pbq2lb	183	14	(	(	-LRB-
cord-267897-w4pbq2lb	183	15	Fig	Fig	NNP
cord-267897-w4pbq2lb	183	16	.	.	.
cord-267897-w4pbq2lb	183	17	18.4	18.4	CD
cord-267897-w4pbq2lb	183	18	)	)	-RRB-
cord-267897-w4pbq2lb	183	19	.	.	.
cord-267897-w4pbq2lb	184	1	One	one	PRP
cord-267897-w4pbq2lb	184	2	can	can	MD
cord-267897-w4pbq2lb	184	3	observe	observe	VB
cord-267897-w4pbq2lb	184	4	a	a	DT
cord-267897-w4pbq2lb	184	5	linear	linear	JJ
cord-267897-w4pbq2lb	184	6	increase	increase	NN
cord-267897-w4pbq2lb	184	7	of	of	IN
cord-267897-w4pbq2lb	184	8	the	the	DT
cord-267897-w4pbq2lb	184	9	bound	bind	VBN
cord-267897-w4pbq2lb	184	10	fraction	fraction	NN
cord-267897-w4pbq2lb	184	11	at	at	IN
cord-267897-w4pbq2lb	184	12	low	low	JJ
cord-267897-w4pbq2lb	184	13	concentrations	concentration	NNS
cord-267897-w4pbq2lb	184	14	of	of	IN
cord-267897-w4pbq2lb	184	15	lysozyme	lysozyme	NNS
cord-267897-w4pbq2lb	184	16	,	,	,
cord-267897-w4pbq2lb	184	17	followed	follow	VBN
cord-267897-w4pbq2lb	184	18	by	by	IN
cord-267897-w4pbq2lb	184	19	a	a	DT
cord-267897-w4pbq2lb	184	20	gradual	gradual	JJ
cord-267897-w4pbq2lb	184	21	inflection	inflection	NN
cord-267897-w4pbq2lb	184	22	of	of	IN
cord-267897-w4pbq2lb	184	23	the	the	DT
cord-267897-w4pbq2lb	184	24	plot	plot	NN
cord-267897-w4pbq2lb	184	25	as	as	IN
cord-267897-w4pbq2lb	184	26	the	the	DT
cord-267897-w4pbq2lb	184	27	concentration	concentration	NN
cord-267897-w4pbq2lb	184	28	increases	increase	VBZ
cord-267897-w4pbq2lb	184	29	to	to	TO
cord-267897-w4pbq2lb	184	30	reach	reach	VB
cord-267897-w4pbq2lb	184	31	an	an	DT
cord-267897-w4pbq2lb	184	32	asymptotic	asymptotic	JJ
cord-267897-w4pbq2lb	184	33	region	region	NN
cord-267897-w4pbq2lb	184	34	where	where	WRB
cord-267897-w4pbq2lb	184	35	all	all	DT
cord-267897-w4pbq2lb	184	36	sites	site	NNS
cord-267897-w4pbq2lb	184	37	become	become	VBP
cord-267897-w4pbq2lb	184	38	occupied	occupy	VBN
cord-267897-w4pbq2lb	184	39	(	(	-LRB-
cord-267897-w4pbq2lb	184	40	Fig	Fig	NNP
cord-267897-w4pbq2lb	184	41	.	.	.
cord-267897-w4pbq2lb	184	42	18.4	18.4	CD
cord-267897-w4pbq2lb	184	43	)	)	-RRB-
cord-267897-w4pbq2lb	184	44	.	.	.
cord-267897-w4pbq2lb	185	1	Besides	besides	IN
cord-267897-w4pbq2lb	185	2	the	the	DT
cord-267897-w4pbq2lb	185	3	apparent	apparent	JJ
cord-267897-w4pbq2lb	185	4	K	k	NN
cord-267897-w4pbq2lb	185	5	eq	eq	NN
cord-267897-w4pbq2lb	185	6	,	,	,
cord-267897-w4pbq2lb	185	7	relevant	relevant	JJ
cord-267897-w4pbq2lb	185	8	information	information	NN
cord-267897-w4pbq2lb	185	9	for	for	IN
cord-267897-w4pbq2lb	185	10	the	the	DT
cord-267897-w4pbq2lb	185	11	experimentalist	experimentalist	NN
cord-267897-w4pbq2lb	185	12	is	be	VBZ
cord-267897-w4pbq2lb	185	13	the	the	DT
cord-267897-w4pbq2lb	185	14	maximal	maximal	JJ
cord-267897-w4pbq2lb	185	15	amount	amount	NN
cord-267897-w4pbq2lb	185	16	of	of	IN
cord-267897-w4pbq2lb	185	17	bound	bind	VBN
cord-267897-w4pbq2lb	185	18	adsorbate	adsorbate	NN
cord-267897-w4pbq2lb	185	19	Q	q	NN
cord-267897-w4pbq2lb	185	20	max	max	NN
cord-267897-w4pbq2lb	185	21	per	per	IN
cord-267897-w4pbq2lb	185	22	surface	surface	NN
cord-267897-w4pbq2lb	185	23	area	area	NN
cord-267897-w4pbq2lb	185	24	or	or	CC
cord-267897-w4pbq2lb	185	25	weight	weight	NN
cord-267897-w4pbq2lb	185	26	of	of	IN
cord-267897-w4pbq2lb	185	27	particulate	particulate	NN
cord-267897-w4pbq2lb	185	28	material	material	NN
cord-267897-w4pbq2lb	185	29	(	(	-LRB-
cord-267897-w4pbq2lb	185	30	value	value	NN
cord-267897-w4pbq2lb	185	31	at	at	IN
cord-267897-w4pbq2lb	185	32	asymptote	asymptote	NNP
cord-267897-w4pbq2lb	185	33	)	)	-RRB-
cord-267897-w4pbq2lb	185	34	,	,	,
cord-267897-w4pbq2lb	185	35	which	which	WDT
cord-267897-w4pbq2lb	185	36	can	can	MD
cord-267897-w4pbq2lb	185	37	be	be	VB
cord-267897-w4pbq2lb	185	38	used	use	VBN
cord-267897-w4pbq2lb	185	39	to	to	TO
cord-267897-w4pbq2lb	185	40	determine	determine	VB
cord-267897-w4pbq2lb	185	41	the	the	DT
cord-267897-w4pbq2lb	185	42	maximal	maximal	JJ
cord-267897-w4pbq2lb	185	43	vaccine	vaccine	NN
cord-267897-w4pbq2lb	185	44	dose	dose	NN
cord-267897-w4pbq2lb	185	45	.	.	.
cord-267897-w4pbq2lb	186	1	Finally	finally	RB
cord-267897-w4pbq2lb	186	2	,	,	,
cord-267897-w4pbq2lb	186	3	the	the	DT
cord-267897-w4pbq2lb	186	4	fitted	fit	VBN
cord-267897-w4pbq2lb	186	5	q	q	NN
cord-267897-w4pbq2lb	186	6	values	value	NNS
cord-267897-w4pbq2lb	186	7	give	give	VBP
cord-267897-w4pbq2lb	186	8	the	the	DT
cord-267897-w4pbq2lb	186	9	fraction	fraction	NN
cord-267897-w4pbq2lb	186	10	of	of	IN
cord-267897-w4pbq2lb	186	11	sites	site	NNS
cord-267897-w4pbq2lb	186	12	occupied	occupy	VBN
cord-267897-w4pbq2lb	186	13	,	,	,
cord-267897-w4pbq2lb	186	14	which	which	WDT
cord-267897-w4pbq2lb	186	15	is	be	VBZ
cord-267897-w4pbq2lb	186	16	also	also	RB
cord-267897-w4pbq2lb	186	17	valuable	valuable	JJ
cord-267897-w4pbq2lb	186	18	information	information	NN
cord-267897-w4pbq2lb	186	19	to	to	TO
cord-267897-w4pbq2lb	186	20	determine	determine	VB
cord-267897-w4pbq2lb	186	21	the	the	DT
cord-267897-w4pbq2lb	186	22	working	work	VBG
cord-267897-w4pbq2lb	186	23	concentration	concentration	NN
cord-267897-w4pbq2lb	186	24	of	of	IN
cord-267897-w4pbq2lb	186	25	antigen	antigen	NN
cord-267897-w4pbq2lb	186	26	needed	need	VBD
cord-267897-w4pbq2lb	186	27	to	to	TO
cord-267897-w4pbq2lb	186	28	achieve	achieve	VB
cord-267897-w4pbq2lb	186	29	a	a	DT
cord-267897-w4pbq2lb	186	30	desired	desire	VBN
cord-267897-w4pbq2lb	186	31	coverage	coverage	NN
cord-267897-w4pbq2lb	186	32	of	of	IN
cord-267897-w4pbq2lb	186	33	the	the	DT
cord-267897-w4pbq2lb	186	34	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	186	35	particles	particle	NNS
cord-267897-w4pbq2lb	186	36	.	.	.
cord-267897-w4pbq2lb	187	1	Reducing	reduce	VBG
cord-267897-w4pbq2lb	187	2	the	the	DT
cord-267897-w4pbq2lb	187	3	concentration	concentration	NN
cord-267897-w4pbq2lb	187	4	(	(	-LRB-
cord-267897-w4pbq2lb	187	5	i.e.	i.e.	FW
cord-267897-w4pbq2lb	187	6	,	,	,
cord-267897-w4pbq2lb	187	7	the	the	DT
cord-267897-w4pbq2lb	187	8	amount	amount	NN
cord-267897-w4pbq2lb	187	9	)	)	-RRB-
cord-267897-w4pbq2lb	187	10	of	of	IN
cord-267897-w4pbq2lb	187	11	antigen	antigen	NN
cord-267897-w4pbq2lb	187	12	to	to	TO
cord-267897-w4pbq2lb	187	13	achieve	achieve	VB
cord-267897-w4pbq2lb	187	14	similar	similar	JJ
cord-267897-w4pbq2lb	187	15	site	site	NN
cord-267897-w4pbq2lb	187	16	occupancy	occupancy	NN
cord-267897-w4pbq2lb	187	17	can	can	MD
cord-267897-w4pbq2lb	187	18	also	also	RB
cord-267897-w4pbq2lb	187	19	prove	prove	VB
cord-267897-w4pbq2lb	187	20	economical	economical	JJ
cord-267897-w4pbq2lb	187	21	with	with	IN
cord-267897-w4pbq2lb	187	22	expensive	expensive	JJ
cord-267897-w4pbq2lb	187	23	antigens	antigen	NNS
cord-267897-w4pbq2lb	187	24	.	.	.
cord-267897-w4pbq2lb	188	1	Figure	figure	NN
cord-267897-w4pbq2lb	188	2	18	18	CD
cord-267897-w4pbq2lb	188	3	.4	.4	.
cord-267897-w4pbq2lb	189	1	Hen	hen	NN
cord-267897-w4pbq2lb	189	2	-	-	HYPH
cord-267897-w4pbq2lb	189	3	egg	egg	NN
cord-267897-w4pbq2lb	189	4	lysozyme	lysozyme	NNS
cord-267897-w4pbq2lb	189	5	adsorption	adsorption	NN
cord-267897-w4pbq2lb	189	6	isotherm	isotherm	NN
cord-267897-w4pbq2lb	189	7	to	to	IN
cord-267897-w4pbq2lb	189	8	Adju	Adju	NNP
cord-267897-w4pbq2lb	189	9	-	-	HYPH
cord-267897-w4pbq2lb	189	10	Phos	Phos	NNP
cord-267897-w4pbq2lb	189	11	.	.	.
cord-267897-w4pbq2lb	190	1	The	the	DT
cord-267897-w4pbq2lb	190	2	raw	raw	JJ
cord-267897-w4pbq2lb	190	3	data	datum	NNS
cord-267897-w4pbq2lb	190	4	was	be	VBD
cord-267897-w4pbq2lb	190	5	fitted	fit	VBN
cord-267897-w4pbq2lb	190	6	with	with	IN
cord-267897-w4pbq2lb	190	7	two	two	CD
cord-267897-w4pbq2lb	190	8	model	model	NN
cord-267897-w4pbq2lb	190	9	isotherms	isotherm	NNS
cord-267897-w4pbq2lb	190	10	,	,	,
cord-267897-w4pbq2lb	190	11	Langmuir	Langmuir	NNP
cord-267897-w4pbq2lb	190	12	(	(	-LRB-
cord-267897-w4pbq2lb	190	13	solid	solid	JJ
cord-267897-w4pbq2lb	190	14	line	line	NN
cord-267897-w4pbq2lb	190	15	)	)	-RRB-
cord-267897-w4pbq2lb	190	16	and	and	CC
cord-267897-w4pbq2lb	190	17	Toth	Toth	NNP
cord-267897-w4pbq2lb	190	18	(	(	-LRB-
cord-267897-w4pbq2lb	190	19	dotted	dotted	JJ
cord-267897-w4pbq2lb	190	20	line	line	NN
cord-267897-w4pbq2lb	190	21	)	)	-RRB-
cord-267897-w4pbq2lb	190	22	.	.	.
cord-267897-w4pbq2lb	191	1	Data	data	NN
cord-267897-w4pbq2lb	191	2	points	point	NNS
cord-267897-w4pbq2lb	191	3	were	be	VBD
cord-267897-w4pbq2lb	191	4	fitted	fit	VBN
cord-267897-w4pbq2lb	191	5	using	use	VBG
cord-267897-w4pbq2lb	191	6	nonlinear	nonlinear	JJ
cord-267897-w4pbq2lb	191	7	least	least	JJS
cord-267897-w4pbq2lb	191	8	squares	square	NNS
cord-267897-w4pbq2lb	191	9	regression	regression	NN
cord-267897-w4pbq2lb	191	10	.	.	.
cord-267897-w4pbq2lb	192	1	The	the	DT
cord-267897-w4pbq2lb	192	2	parameters	parameter	NNS
cord-267897-w4pbq2lb	192	3	extracted	extract	VBN
cord-267897-w4pbq2lb	192	4	from	from	IN
cord-267897-w4pbq2lb	192	5	the	the	DT
cord-267897-w4pbq2lb	192	6	fitting	fitting	NN
cord-267897-w4pbq2lb	192	7	are	be	VBP
cord-267897-w4pbq2lb	192	8	R	R	NNP
cord-267897-w4pbq2lb	192	9	2	2	CD
cord-267897-w4pbq2lb	192	10	,	,	,
cord-267897-w4pbq2lb	192	11	the	the	DT
cord-267897-w4pbq2lb	192	12	adjusted	adjust	VBN
cord-267897-w4pbq2lb	192	13	coefficient	coefficient	NN
cord-267897-w4pbq2lb	192	14	of	of	IN
cord-267897-w4pbq2lb	192	15	determination	determination	NN
cord-267897-w4pbq2lb	192	16	;	;	.
cord-267897-w4pbq2lb	193	1	B	B	NNP
cord-267897-w4pbq2lb	193	2	max	max	NNP
cord-267897-w4pbq2lb	193	3	,	,	,
cord-267897-w4pbq2lb	193	4	the	the	DT
cord-267897-w4pbq2lb	193	5	maximal	maximal	JJ
cord-267897-w4pbq2lb	193	6	amount	amount	NN
cord-267897-w4pbq2lb	193	7	of	of	IN
cord-267897-w4pbq2lb	193	8	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	193	9	molecules	molecule	NNS
cord-267897-w4pbq2lb	193	10	(	(	-LRB-
cord-267897-w4pbq2lb	193	11	in	in	IN
cord-267897-w4pbq2lb	193	12	nmoles	nmoles	NNP
cord-267897-w4pbq2lb	193	13	)	)	-RRB-
cord-267897-w4pbq2lb	193	14	;	;	:
cord-267897-w4pbq2lb	193	15	K	K	NNP
cord-267897-w4pbq2lb	193	16	eq	eq	NNP
cord-267897-w4pbq2lb	193	17	,	,	,
cord-267897-w4pbq2lb	193	18	the	the	DT
cord-267897-w4pbq2lb	193	19	apparent	apparent	JJ
cord-267897-w4pbq2lb	193	20	equilibrium	equilibrium	NN
cord-267897-w4pbq2lb	193	21	constant	constant	NN
cord-267897-w4pbq2lb	193	22	(	(	-LRB-
cord-267897-w4pbq2lb	193	23	in	in	IN
cord-267897-w4pbq2lb	193	24	liter	liter	NN
cord-267897-w4pbq2lb	193	25	/	/	SYM
cord-267897-w4pbq2lb	193	26	mole	mole	NN
cord-267897-w4pbq2lb	193	27	)	)	-RRB-
cord-267897-w4pbq2lb	193	28	;	;	:
cord-267897-w4pbq2lb	193	29	and	and	CC
cord-267897-w4pbq2lb	193	30	t	t	XX
cord-267897-w4pbq2lb	193	31	,	,	,
cord-267897-w4pbq2lb	193	32	the	the	DT
cord-267897-w4pbq2lb	193	33	exponent	exponent	NN
cord-267897-w4pbq2lb	193	34	in	in	IN
cord-267897-w4pbq2lb	193	35	the	the	DT
cord-267897-w4pbq2lb	193	36	Toth	Toth	NNP
cord-267897-w4pbq2lb	193	37	equation	equation	NN
cord-267897-w4pbq2lb	193	38	.	.	.
cord-267897-w4pbq2lb	194	1	Increasing	increase	VBG
cord-267897-w4pbq2lb	194	2	concentrations	concentration	NNS
cord-267897-w4pbq2lb	194	3	of	of	IN
cord-267897-w4pbq2lb	194	4	lysozyme	lysozyme	NNS
cord-267897-w4pbq2lb	194	5	were	be	VBD
cord-267897-w4pbq2lb	194	6	admixed	admix	VBN
cord-267897-w4pbq2lb	194	7	with	with	IN
cord-267897-w4pbq2lb	194	8	a	a	DT
cord-267897-w4pbq2lb	194	9	fixed	fix	VBN
cord-267897-w4pbq2lb	194	10	amount	amount	NN
cord-267897-w4pbq2lb	194	11	of	of	IN
cord-267897-w4pbq2lb	194	12	buffered	buffer	VBN
cord-267897-w4pbq2lb	194	13	Adju	Adju	NNP
cord-267897-w4pbq2lb	194	14	-	-	HYPH
cord-267897-w4pbq2lb	194	15	Phos	Phos	NNP
cord-267897-w4pbq2lb	194	16	particles	particle	NNS
cord-267897-w4pbq2lb	194	17	(	(	-LRB-
cord-267897-w4pbq2lb	194	18	0.8	0.8	CD
cord-267897-w4pbq2lb	194	19	AE	AE	NNP
cord-267897-w4pbq2lb	194	20	0.2	0.2	CD
cord-267897-w4pbq2lb	194	21	mm	mm	NN
cord-267897-w4pbq2lb	194	22	diameter	diameter	NN
cord-267897-w4pbq2lb	194	23	,	,	,
cord-267897-w4pbq2lb	194	24	À15	À15	NNP
cord-267897-w4pbq2lb	194	25	mV	mV	NNP
cord-267897-w4pbq2lb	194	26	z	z	NNP
cord-267897-w4pbq2lb	194	27	-	-	HYPH
cord-267897-w4pbq2lb	194	28	potential	potential	NN
cord-267897-w4pbq2lb	194	29	)	)	-RRB-
cord-267897-w4pbq2lb	194	30	suspended	suspend	VBN
cord-267897-w4pbq2lb	194	31	in	in	IN
cord-267897-w4pbq2lb	194	32	imidazole	imidazole	JJ
cord-267897-w4pbq2lb	194	33	10	10	CD
cord-267897-w4pbq2lb	194	34	mM	mm	CD
cord-267897-w4pbq2lb	194	35	at	at	IN
cord-267897-w4pbq2lb	194	36	pH	pH	NNP
cord-267897-w4pbq2lb	194	37	7.1	7.1	CD
cord-267897-w4pbq2lb	194	38	and	and	CC
cord-267897-w4pbq2lb	194	39	incubated	incubate	VBN
cord-267897-w4pbq2lb	194	40	at	at	IN
cord-267897-w4pbq2lb	194	41	25	25	CD
cord-267897-w4pbq2lb	194	42	C	c	NN
cord-267897-w4pbq2lb	194	43	for	for	IN
cord-267897-w4pbq2lb	194	44	60	60	CD
cord-267897-w4pbq2lb	194	45	min	min	NN
cord-267897-w4pbq2lb	194	46	(	(	-LRB-
cord-267897-w4pbq2lb	194	47	apparent	apparent	JJ
cord-267897-w4pbq2lb	194	48	equilibria	equilibrium	NNS
cord-267897-w4pbq2lb	194	49	were	be	VBD
cord-267897-w4pbq2lb	194	50	reached	reach	VBN
cord-267897-w4pbq2lb	194	51	within	within	IN
cord-267897-w4pbq2lb	194	52	20	20	CD
cord-267897-w4pbq2lb	194	53	min	min	NN
cord-267897-w4pbq2lb	194	54	)	)	-RRB-
cord-267897-w4pbq2lb	194	55	.	.	.
cord-267897-w4pbq2lb	195	1	Adsorbed	Adsorbed	NNP
cord-267897-w4pbq2lb	195	2	lysozyme	lysozyme	NNS
cord-267897-w4pbq2lb	195	3	was	be	VBD
cord-267897-w4pbq2lb	195	4	deduced	deduce	VBN
cord-267897-w4pbq2lb	195	5	from	from	IN
cord-267897-w4pbq2lb	195	6	the	the	DT
cord-267897-w4pbq2lb	195	7	difference	difference	NN
cord-267897-w4pbq2lb	195	8	in	in	IN
cord-267897-w4pbq2lb	195	9	ultraviolet	ultraviolet	NN
cord-267897-w4pbq2lb	195	10	absorbance	absorbance	NN
cord-267897-w4pbq2lb	195	11	at	at	IN
cord-267897-w4pbq2lb	195	12	280	280	CD
cord-267897-w4pbq2lb	195	13	nm	nm	NN
cord-267897-w4pbq2lb	195	14	between	between	IN
cord-267897-w4pbq2lb	195	15	the	the	DT
cord-267897-w4pbq2lb	195	16	initial	initial	JJ
cord-267897-w4pbq2lb	195	17	solution	solution	NN
cord-267897-w4pbq2lb	195	18	and	and	CC
cord-267897-w4pbq2lb	195	19	the	the	DT
cord-267897-w4pbq2lb	195	20	admixture	admixture	NN
cord-267897-w4pbq2lb	195	21	supernatant	supernatant	JJ
cord-267897-w4pbq2lb	195	22	after	after	IN
cord-267897-w4pbq2lb	195	23	centrifugal	centrifugal	JJ
cord-267897-w4pbq2lb	195	24	sedimentation	sedimentation	NN
cord-267897-w4pbq2lb	195	25	of	of	IN
cord-267897-w4pbq2lb	195	26	the	the	DT
cord-267897-w4pbq2lb	195	27	particles	particle	NNS
cord-267897-w4pbq2lb	195	28	.	.	.
cord-267897-w4pbq2lb	196	1	Finally	finally	RB
cord-267897-w4pbq2lb	196	2	,	,	,
cord-267897-w4pbq2lb	196	3	one	one	PRP
cord-267897-w4pbq2lb	196	4	should	should	MD
cord-267897-w4pbq2lb	196	5	emphasize	emphasize	VB
cord-267897-w4pbq2lb	196	6	that	that	IN
cord-267897-w4pbq2lb	196	7	the	the	DT
cord-267897-w4pbq2lb	196	8	variables	variable	NNS
cord-267897-w4pbq2lb	196	9	extracted	extract	VBN
cord-267897-w4pbq2lb	196	10	by	by	IN
cord-267897-w4pbq2lb	196	11	fitting	fit	VBG
cord-267897-w4pbq2lb	196	12	with	with	IN
cord-267897-w4pbq2lb	196	13	the	the	DT
cord-267897-w4pbq2lb	196	14	two	two	CD
cord-267897-w4pbq2lb	196	15	isotherms	isotherm	NNS
cord-267897-w4pbq2lb	196	16	differ	differ	VBP
cord-267897-w4pbq2lb	196	17	,	,	,
cord-267897-w4pbq2lb	196	18	as	as	IN
cord-267897-w4pbq2lb	196	19	expected	expect	VBN
cord-267897-w4pbq2lb	196	20	.	.	.
cord-267897-w4pbq2lb	197	1	It	-PRON-	PRP
cord-267897-w4pbq2lb	197	2	is	be	VBZ
cord-267897-w4pbq2lb	197	3	noticeable	noticeable	JJ
cord-267897-w4pbq2lb	197	4	that	that	IN
cord-267897-w4pbq2lb	197	5	the	the	DT
cord-267897-w4pbq2lb	197	6	goodness	goodness	NN
cord-267897-w4pbq2lb	197	7	of	of	IN
cord-267897-w4pbq2lb	197	8	fit	fit	NN
cord-267897-w4pbq2lb	197	9	,	,	,
cord-267897-w4pbq2lb	197	10	measured	measure	VBN
cord-267897-w4pbq2lb	197	11	by	by	IN
cord-267897-w4pbq2lb	197	12	the	the	DT
cord-267897-w4pbq2lb	197	13	adjusted	adjust	VBN
cord-267897-w4pbq2lb	197	14	R	R	NNP
cord-267897-w4pbq2lb	197	15	2	2	CD
cord-267897-w4pbq2lb	197	16	,	,	,
cord-267897-w4pbq2lb	197	17	with	with	IN
cord-267897-w4pbq2lb	197	18	the	the	DT
cord-267897-w4pbq2lb	197	19	Toth	Toth	NNP
cord-267897-w4pbq2lb	197	20	isotherm	isotherm	NN
cord-267897-w4pbq2lb	197	21	is	be	VBZ
cord-267897-w4pbq2lb	197	22	slightly	slightly	RB
cord-267897-w4pbq2lb	197	23	improved	improve	VBN
cord-267897-w4pbq2lb	197	24	over	over	IN
cord-267897-w4pbq2lb	197	25	the	the	DT
cord-267897-w4pbq2lb	197	26	Langmuir	Langmuir	NNP
cord-267897-w4pbq2lb	197	27	isotherm	isotherm	NN
cord-267897-w4pbq2lb	197	28	Fig	fig	NN
cord-267897-w4pbq2lb	197	29	.	.	.
cord-267897-w4pbq2lb	198	1	18	18	CD
cord-267897-w4pbq2lb	198	2	.4	.4	CD
cord-267897-w4pbq2lb	198	3	,	,	,
cord-267897-w4pbq2lb	198	4	suggesting	suggest	VBG
cord-267897-w4pbq2lb	198	5	that	that	IN
cord-267897-w4pbq2lb	198	6	in	in	IN
cord-267897-w4pbq2lb	198	7	this	this	DT
cord-267897-w4pbq2lb	198	8	particular	particular	JJ
cord-267897-w4pbq2lb	198	9	system	system	NN
cord-267897-w4pbq2lb	198	10	the	the	DT
cord-267897-w4pbq2lb	198	11	mechanism	mechanism	NN
cord-267897-w4pbq2lb	198	12	of	of	IN
cord-267897-w4pbq2lb	198	13	adsorption	adsorption	NN
cord-267897-w4pbq2lb	198	14	does	do	VBZ
cord-267897-w4pbq2lb	198	15	appear	appear	VB
cord-267897-w4pbq2lb	198	16	to	to	TO
cord-267897-w4pbq2lb	198	17	deviate	deviate	VB
cord-267897-w4pbq2lb	198	18	from	from	IN
cord-267897-w4pbq2lb	198	19	the	the	DT
cord-267897-w4pbq2lb	198	20	Langmuir	Langmuir	NNP
cord-267897-w4pbq2lb	198	21	model	model	NN
cord-267897-w4pbq2lb	198	22	.	.	.
cord-267897-w4pbq2lb	199	1	This	this	DT
cord-267897-w4pbq2lb	199	2	situation	situation	NN
cord-267897-w4pbq2lb	199	3	may	may	MD
cord-267897-w4pbq2lb	199	4	be	be	VB
cord-267897-w4pbq2lb	199	5	very	very	RB
cord-267897-w4pbq2lb	199	6	different	different	JJ
cord-267897-w4pbq2lb	199	7	in	in	IN
cord-267897-w4pbq2lb	199	8	other	other	JJ
cord-267897-w4pbq2lb	199	9	systems	system	NNS
cord-267897-w4pbq2lb	199	10	in	in	IN
cord-267897-w4pbq2lb	199	11	which	which	WDT
cord-267897-w4pbq2lb	199	12	significant	significant	JJ
cord-267897-w4pbq2lb	199	13	deviation	deviation	NN
cord-267897-w4pbq2lb	199	14	from	from	IN
cord-267897-w4pbq2lb	199	15	the	the	DT
cord-267897-w4pbq2lb	199	16	Langmuir	Langmuir	NNP
cord-267897-w4pbq2lb	199	17	isotherm	isotherm	NN
cord-267897-w4pbq2lb	199	18	are	be	VBP
cord-267897-w4pbq2lb	199	19	encountered	encounter	VBN
cord-267897-w4pbq2lb	199	20	.	.	.
cord-267897-w4pbq2lb	200	1	70	70	CD
cord-267897-w4pbq2lb	201	1	It	-PRON-	PRP
cord-267897-w4pbq2lb	201	2	is	be	VBZ
cord-267897-w4pbq2lb	201	3	also	also	RB
cord-267897-w4pbq2lb	201	4	noticeable	noticeable	JJ
cord-267897-w4pbq2lb	201	5	that	that	IN
cord-267897-w4pbq2lb	201	6	somewhat	somewhat	RB
cord-267897-w4pbq2lb	201	7	different	different	JJ
cord-267897-w4pbq2lb	201	8	values	value	NNS
cord-267897-w4pbq2lb	201	9	for	for	IN
cord-267897-w4pbq2lb	201	10	Q	Q	NNP
cord-267897-w4pbq2lb	201	11	max	max	NNP
cord-267897-w4pbq2lb	201	12	(	(	-LRB-
cord-267897-w4pbq2lb	201	13	maximal	maximal	JJ
cord-267897-w4pbq2lb	201	14	quantity	quantity	NN
cord-267897-w4pbq2lb	201	15	of	of	IN
cord-267897-w4pbq2lb	201	16	adsorbed	adsorbed	JJ
cord-267897-w4pbq2lb	201	17	molecules	molecule	NNS
cord-267897-w4pbq2lb	201	18	)	)	-RRB-
cord-267897-w4pbq2lb	201	19	and	and	CC
cord-267897-w4pbq2lb	201	20	K	K	NNP
cord-267897-w4pbq2lb	201	21	eq	eq	NNP
cord-267897-w4pbq2lb	201	22	are	be	VBP
cord-267897-w4pbq2lb	201	23	obtained	obtain	VBN
cord-267897-w4pbq2lb	201	24	from	from	IN
cord-267897-w4pbq2lb	201	25	the	the	DT
cord-267897-w4pbq2lb	201	26	two	two	CD
cord-267897-w4pbq2lb	201	27	models	model	NNS
cord-267897-w4pbq2lb	201	28	(	(	-LRB-
cord-267897-w4pbq2lb	201	29	Fig	Fig	NNP
cord-267897-w4pbq2lb	201	30	.	.	.
cord-267897-w4pbq2lb	201	31	18.4	18.4	CD
cord-267897-w4pbq2lb	201	32	)	)	-RRB-
cord-267897-w4pbq2lb	201	33	,	,	,
cord-267897-w4pbq2lb	201	34	as	as	IN
cord-267897-w4pbq2lb	201	35	a	a	DT
cord-267897-w4pbq2lb	201	36	reminder	reminder	NN
cord-267897-w4pbq2lb	201	37	that	that	IN
cord-267897-w4pbq2lb	201	38	critical	critical	JJ
cord-267897-w4pbq2lb	201	39	judgment	judgment	NN
cord-267897-w4pbq2lb	201	40	should	should	MD
cord-267897-w4pbq2lb	201	41	be	be	VB
cord-267897-w4pbq2lb	201	42	exerted	exert	VBN
cord-267897-w4pbq2lb	201	43	upon	upon	IN
cord-267897-w4pbq2lb	201	44	their	-PRON-	PRP$
cord-267897-w4pbq2lb	201	45	significance	significance	NN
cord-267897-w4pbq2lb	201	46	.	.	.
cord-267897-w4pbq2lb	202	1	In	in	IN
cord-267897-w4pbq2lb	202	2	the	the	DT
cord-267897-w4pbq2lb	202	3	older	old	JJR
cord-267897-w4pbq2lb	202	4	literature	literature	NN
cord-267897-w4pbq2lb	202	5	,	,	,
cord-267897-w4pbq2lb	202	6	aluminum	aluminum	NN
cord-267897-w4pbq2lb	202	7	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	202	8	were	be	VBD
cord-267897-w4pbq2lb	202	9	often	often	RB
cord-267897-w4pbq2lb	202	10	claimed	claim	VBN
cord-267897-w4pbq2lb	202	11	not	not	RB
cord-267897-w4pbq2lb	202	12	to	to	TO
cord-267897-w4pbq2lb	202	13	be	be	VB
cord-267897-w4pbq2lb	202	14	"	"	``
cord-267897-w4pbq2lb	202	15	T	t	NN
cord-267897-w4pbq2lb	202	16	-	-	HYPH
cord-267897-w4pbq2lb	202	17	cell	cell	NN
cord-267897-w4pbq2lb	202	18	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	202	19	.	.	.
cord-267897-w4pbq2lb	202	20	"	"	''
cord-267897-w4pbq2lb	203	1	However	however	RB
cord-267897-w4pbq2lb	203	2	,	,	,
cord-267897-w4pbq2lb	203	3	this	this	DT
cord-267897-w4pbq2lb	203	4	is	be	VBZ
cord-267897-w4pbq2lb	203	5	mostly	mostly	RB
cord-267897-w4pbq2lb	203	6	based	base	VBN
cord-267897-w4pbq2lb	203	7	on	on	IN
cord-267897-w4pbq2lb	203	8	work	work	NN
cord-267897-w4pbq2lb	203	9	from	from	IN
cord-267897-w4pbq2lb	203	10	a	a	DT
cord-267897-w4pbq2lb	203	11	period	period	NN
cord-267897-w4pbq2lb	203	12	in	in	IN
cord-267897-w4pbq2lb	203	13	which	which	WDT
cord-267897-w4pbq2lb	203	14	a	a	DT
cord-267897-w4pbq2lb	203	15	"	"	``
cord-267897-w4pbq2lb	203	16	T	t	NN
cord-267897-w4pbq2lb	203	17	-	-	HYPH
cord-267897-w4pbq2lb	203	18	cell	cell	NN
cord-267897-w4pbq2lb	203	19	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	203	20	"	"	''
cord-267897-w4pbq2lb	203	21	was	be	VBD
cord-267897-w4pbq2lb	203	22	primarily	primarily	RB
cord-267897-w4pbq2lb	203	23	an	an	DT
cord-267897-w4pbq2lb	203	24	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	203	25	capable	capable	JJ
cord-267897-w4pbq2lb	203	26	of	of	IN
cord-267897-w4pbq2lb	203	27	inducing	induce	VBG
cord-267897-w4pbq2lb	203	28	a	a	DT
cord-267897-w4pbq2lb	203	29	delayed	delay	VBN
cord-267897-w4pbq2lb	203	30	-	-	HYPH
cord-267897-w4pbq2lb	203	31	type	type	NN
cord-267897-w4pbq2lb	203	32	hypersensitivity	hypersensitivity	NN
cord-267897-w4pbq2lb	203	33	(	(	-LRB-
cord-267897-w4pbq2lb	203	34	DTH	DTH	NNP
cord-267897-w4pbq2lb	203	35	)	)	-RRB-
cord-267897-w4pbq2lb	203	36	response	response	NN
cord-267897-w4pbq2lb	203	37	.	.	.
cord-267897-w4pbq2lb	204	1	Such	such	JJ
cord-267897-w4pbq2lb	204	2	generalizations	generalization	NNS
cord-267897-w4pbq2lb	204	3	are	be	VBP
cord-267897-w4pbq2lb	204	4	now	now	RB
cord-267897-w4pbq2lb	204	5	considered	consider	VBN
cord-267897-w4pbq2lb	204	6	too	too	RB
cord-267897-w4pbq2lb	204	7	simple	simple	JJ
cord-267897-w4pbq2lb	204	8	and	and	CC
cord-267897-w4pbq2lb	204	9	obsolete	obsolete	JJ
cord-267897-w4pbq2lb	204	10	.	.	.
cord-267897-w4pbq2lb	205	1	It	-PRON-	PRP
cord-267897-w4pbq2lb	205	2	is	be	VBZ
cord-267897-w4pbq2lb	205	3	correct	correct	JJ
cord-267897-w4pbq2lb	205	4	that	that	IN
cord-267897-w4pbq2lb	205	5	aluminum	aluminum	NN
cord-267897-w4pbq2lb	205	6	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	205	7	are	be	VBP
cord-267897-w4pbq2lb	205	8	not	not	RB
cord-267897-w4pbq2lb	205	9	efficient	efficient	JJ
cord-267897-w4pbq2lb	205	10	DTH	DTH	NNP
cord-267897-w4pbq2lb	205	11	inducers	inducer	NNS
cord-267897-w4pbq2lb	205	12	in	in	IN
cord-267897-w4pbq2lb	205	13	rodents	rodent	NNS
cord-267897-w4pbq2lb	205	14	,	,	,
cord-267897-w4pbq2lb	205	15	as	as	IN
cord-267897-w4pbq2lb	205	16	pointed	point	VBN
cord-267897-w4pbq2lb	205	17	out	out	RP
cord-267897-w4pbq2lb	205	18	by	by	IN
cord-267897-w4pbq2lb	205	19	Robert	Robert	NNP
cord-267897-w4pbq2lb	205	20	Bomford	Bomford	NNP
cord-267897-w4pbq2lb	205	21	.	.	.
cord-267897-w4pbq2lb	206	1	74	74	CD
cord-267897-w4pbq2lb	207	1	There	there	EX
cord-267897-w4pbq2lb	207	2	is	be	VBZ
cord-267897-w4pbq2lb	207	3	also	also	RB
cord-267897-w4pbq2lb	207	4	very	very	RB
cord-267897-w4pbq2lb	207	5	little	little	JJ
cord-267897-w4pbq2lb	207	6	evidence	evidence	NN
cord-267897-w4pbq2lb	207	7	that	that	IN
cord-267897-w4pbq2lb	207	8	aluminum	aluminum	NN
cord-267897-w4pbq2lb	207	9	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	207	10	should	should	MD
cord-267897-w4pbq2lb	207	11	be	be	VB
cord-267897-w4pbq2lb	207	12	able	able	JJ
cord-267897-w4pbq2lb	207	13	to	to	TO
cord-267897-w4pbq2lb	207	14	generate	generate	VB
cord-267897-w4pbq2lb	207	15	MHC	MHC	NNP
cord-267897-w4pbq2lb	207	16	class	class	NN
cord-267897-w4pbq2lb	207	17	Ierestricted	Ierestricted	NNP
cord-267897-w4pbq2lb	207	18	cytotoxic	cytotoxic	JJ
cord-267897-w4pbq2lb	207	19	T	t	NN
cord-267897-w4pbq2lb	207	20	cells	cell	NNS
cord-267897-w4pbq2lb	207	21	;	;	:
cord-267897-w4pbq2lb	207	22	so	so	RB
cord-267897-w4pbq2lb	207	23	far	far	RB
cord-267897-w4pbq2lb	207	24	there	there	EX
cord-267897-w4pbq2lb	207	25	is	be	VBZ
cord-267897-w4pbq2lb	207	26	only	only	RB
cord-267897-w4pbq2lb	207	27	a	a	DT
cord-267897-w4pbq2lb	207	28	single	single	JJ
cord-267897-w4pbq2lb	207	29	report	report	NN
cord-267897-w4pbq2lb	207	30	from	from	IN
cord-267897-w4pbq2lb	207	31	Dillon	Dillon	NNP
cord-267897-w4pbq2lb	207	32	and	and	CC
cord-267897-w4pbq2lb	207	33	coworkers	coworker	NNS
cord-267897-w4pbq2lb	207	34	75	75	CD
cord-267897-w4pbq2lb	207	35	using	use	VBG
cord-267897-w4pbq2lb	207	36	a	a	DT
cord-267897-w4pbq2lb	207	37	recombinant	recombinant	JJ
cord-267897-w4pbq2lb	207	38	influenza	influenza	NN
cord-267897-w4pbq2lb	207	39	vaccine	vaccine	NN
cord-267897-w4pbq2lb	207	40	in	in	IN
cord-267897-w4pbq2lb	207	41	mice	mouse	NNS
cord-267897-w4pbq2lb	207	42	.	.	.
cord-267897-w4pbq2lb	208	1	However	however	RB
cord-267897-w4pbq2lb	208	2	,	,	,
cord-267897-w4pbq2lb	208	3	as	as	RB
cord-267897-w4pbq2lb	208	4	early	early	RB
cord-267897-w4pbq2lb	208	5	as	as	IN
cord-267897-w4pbq2lb	208	6	the	the	DT
cord-267897-w4pbq2lb	208	7	1970s	1970	NNS
cord-267897-w4pbq2lb	208	8	'	'	POS
cord-267897-w4pbq2lb	208	9	,	,	,
cord-267897-w4pbq2lb	208	10	the	the	DT
cord-267897-w4pbq2lb	208	11	ability	ability	NN
cord-267897-w4pbq2lb	208	12	of	of	IN
cord-267897-w4pbq2lb	208	13	aluminum	aluminum	NN
cord-267897-w4pbq2lb	208	14	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	208	15	to	to	TO
cord-267897-w4pbq2lb	208	16	induce	induce	VB
cord-267897-w4pbq2lb	208	17	eosinophilia	eosinophilia	NN
cord-267897-w4pbq2lb	208	18	was	be	VBD
cord-267897-w4pbq2lb	208	19	shown	show	VBN
cord-267897-w4pbq2lb	208	20	to	to	TO
cord-267897-w4pbq2lb	208	21	require	require	VB
cord-267897-w4pbq2lb	208	22	the	the	DT
cord-267897-w4pbq2lb	208	23	presence	presence	NN
cord-267897-w4pbq2lb	208	24	of	of	IN
cord-267897-w4pbq2lb	208	25	T	T	NNP
cord-267897-w4pbq2lb	208	26	cells	cell	NNS
cord-267897-w4pbq2lb	208	27	76	76	CD
cord-267897-w4pbq2lb	208	28	and	and	CC
cord-267897-w4pbq2lb	208	29	the	the	DT
cord-267897-w4pbq2lb	208	30	reaction	reaction	NN
cord-267897-w4pbq2lb	208	31	profile	profile	NN
cord-267897-w4pbq2lb	208	32	of	of	IN
cord-267897-w4pbq2lb	208	33	aluminum	aluminum	NN
cord-267897-w4pbq2lb	208	34	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	208	35	was	be	VBD
cord-267897-w4pbq2lb	208	36	shown	show	VBN
cord-267897-w4pbq2lb	208	37	to	to	TO
cord-267897-w4pbq2lb	208	38	comprise	comprise	VB
cord-267897-w4pbq2lb	208	39	stimulation	stimulation	NN
cord-267897-w4pbq2lb	208	40	of	of	IN
cord-267897-w4pbq2lb	208	41	CD4	CD4	NNP
cord-267897-w4pbq2lb	208	42	þ	þ	NNP
cord-267897-w4pbq2lb	208	43	T	T	NNP
cord-267897-w4pbq2lb	208	44	cells	cell	NNS
cord-267897-w4pbq2lb	208	45	.	.	.
cord-267897-w4pbq2lb	209	1	77	77	CD
cord-267897-w4pbq2lb	210	1	Among	among	IN
cord-267897-w4pbq2lb	210	2	the	the	DT
cord-267897-w4pbq2lb	210	3	early	early	JJ
cord-267897-w4pbq2lb	210	4	observations	observation	NNS
cord-267897-w4pbq2lb	210	5	in	in	IN
cord-267897-w4pbq2lb	210	6	classical	classical	JJ
cord-267897-w4pbq2lb	210	7	animal	animal	NN
cord-267897-w4pbq2lb	210	8	models	model	NNS
cord-267897-w4pbq2lb	210	9	was	be	VBD
cord-267897-w4pbq2lb	210	10	the	the	DT
cord-267897-w4pbq2lb	210	11	demonstration	demonstration	NN
cord-267897-w4pbq2lb	210	12	of	of	IN
cord-267897-w4pbq2lb	210	13	Mannhalter	Mannhalter	NNP
cord-267897-w4pbq2lb	210	14	that	that	IN
cord-267897-w4pbq2lb	210	15	aluminum	aluminum	NN
cord-267897-w4pbq2lb	210	16	-	-	HYPH
cord-267897-w4pbq2lb	210	17	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	210	18	tetanus	tetanus	NN
cord-267897-w4pbq2lb	210	19	toxoid	toxoid	NN
cord-267897-w4pbq2lb	210	20	led	lead	VBD
cord-267897-w4pbq2lb	210	21	to	to	IN
cord-267897-w4pbq2lb	210	22	an	an	DT
cord-267897-w4pbq2lb	210	23	increase	increase	NN
cord-267897-w4pbq2lb	210	24	in	in	IN
cord-267897-w4pbq2lb	210	25	antigeninduced	antigeninduced	JJ
cord-267897-w4pbq2lb	210	26	T	t	NN
cord-267897-w4pbq2lb	210	27	-	-	HYPH
cord-267897-w4pbq2lb	210	28	cell	cell	NN
cord-267897-w4pbq2lb	210	29	proliferation	proliferation	NN
cord-267897-w4pbq2lb	210	30	,	,	,
cord-267897-w4pbq2lb	210	31	apparently	apparently	RB
cord-267897-w4pbq2lb	210	32	due	due	JJ
cord-267897-w4pbq2lb	210	33	to	to	IN
cord-267897-w4pbq2lb	210	34	increased	increase	VBN
cord-267897-w4pbq2lb	210	35	release	release	NN
cord-267897-w4pbq2lb	210	36	of	of	IN
cord-267897-w4pbq2lb	210	37	IL-1	IL-1	NNP
cord-267897-w4pbq2lb	210	38	.	.	.
cord-267897-w4pbq2lb	210	39	51	51	CD
cord-267897-w4pbq2lb	211	1	In	in	IN
cord-267897-w4pbq2lb	211	2	contrast	contrast	NN
cord-267897-w4pbq2lb	211	3	,	,	,
cord-267897-w4pbq2lb	211	4	there	there	EX
cord-267897-w4pbq2lb	211	5	was	be	VBD
cord-267897-w4pbq2lb	211	6	a	a	DT
cord-267897-w4pbq2lb	211	7	lack	lack	NN
cord-267897-w4pbq2lb	211	8	of	of	IN
cord-267897-w4pbq2lb	211	9	importance	importance	NN
cord-267897-w4pbq2lb	211	10	of	of	IN
cord-267897-w4pbq2lb	211	11	IL-1	IL-1	NNP
cord-267897-w4pbq2lb	211	12	in	in	IN
cord-267897-w4pbq2lb	211	13	the	the	DT
cord-267897-w4pbq2lb	211	14	augmentation	augmentation	NN
cord-267897-w4pbq2lb	211	15	of	of	IN
cord-267897-w4pbq2lb	211	16	the	the	DT
cord-267897-w4pbq2lb	211	17	primary	primary	JJ
cord-267897-w4pbq2lb	211	18	antibody	antibody	NN
cord-267897-w4pbq2lb	211	19	response	response	NN
cord-267897-w4pbq2lb	211	20	in	in	IN
cord-267897-w4pbq2lb	211	21	rabbits	rabbit	NNS
cord-267897-w4pbq2lb	211	22	immunized	immunize	VBN
cord-267897-w4pbq2lb	211	23	with	with	IN
cord-267897-w4pbq2lb	211	24	aluminum	aluminum	NN
cord-267897-w4pbq2lb	211	25	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	211	26	.	.	.
cord-267897-w4pbq2lb	212	1	78	78	CD
cord-267897-w4pbq2lb	212	2	Grun	Grun	NNP
cord-267897-w4pbq2lb	212	3	and	and	CC
cord-267897-w4pbq2lb	212	4	Maurer	Maurer	NNP
cord-267897-w4pbq2lb	212	5	77	77	CD
cord-267897-w4pbq2lb	212	6	demonstrated	demonstrate	VBD
cord-267897-w4pbq2lb	212	7	that	that	IN
cord-267897-w4pbq2lb	212	8	anti	anti	NNS
cord-267897-w4pbq2lb	212	9	-	-	JJ
cord-267897-w4pbq2lb	212	10	IL-1a	il-1a	JJ
cord-267897-w4pbq2lb	212	11	or	or	CC
cord-267897-w4pbq2lb	212	12	anti	anti	JJ
cord-267897-w4pbq2lb	212	13	-	-	NNP
cord-267897-w4pbq2lb	212	14	IL-4	IL-4	NNP
cord-267897-w4pbq2lb	212	15	was	be	VBD
cord-267897-w4pbq2lb	212	16	able	able	JJ
cord-267897-w4pbq2lb	212	17	to	to	TO
cord-267897-w4pbq2lb	212	18	inhibit	inhibit	VB
cord-267897-w4pbq2lb	212	19	an	an	DT
cord-267897-w4pbq2lb	212	20	antigen	antigen	NN
cord-267897-w4pbq2lb	212	21	-	-	HYPH
cord-267897-w4pbq2lb	212	22	specific	specific	JJ
cord-267897-w4pbq2lb	212	23	T	t	NN
cord-267897-w4pbq2lb	212	24	-	-	HYPH
cord-267897-w4pbq2lb	212	25	cell	cell	NN
cord-267897-w4pbq2lb	212	26	proliferative	proliferative	JJ
cord-267897-w4pbq2lb	212	27	response	response	NN
cord-267897-w4pbq2lb	212	28	after	after	IN
cord-267897-w4pbq2lb	212	29	immunization	immunization	NN
cord-267897-w4pbq2lb	212	30	with	with	IN
cord-267897-w4pbq2lb	212	31	aluminum	aluminum	NN
cord-267897-w4pbq2lb	212	32	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	212	33	.	.	.
cord-267897-w4pbq2lb	213	1	This	this	DT
cord-267897-w4pbq2lb	213	2	was	be	VBD
cord-267897-w4pbq2lb	213	3	not	not	RB
cord-267897-w4pbq2lb	213	4	the	the	DT
cord-267897-w4pbq2lb	213	5	case	case	NN
cord-267897-w4pbq2lb	213	6	if	if	IN
cord-267897-w4pbq2lb	213	7	the	the	DT
cord-267897-w4pbq2lb	213	8	mice	mouse	NNS
cord-267897-w4pbq2lb	213	9	were	be	VBD
cord-267897-w4pbq2lb	213	10	immunized	immunize	VBN
cord-267897-w4pbq2lb	213	11	with	with	IN
cord-267897-w4pbq2lb	213	12	Freund	Freund	NNP
cord-267897-w4pbq2lb	213	13	complete	complete	NN
cord-267897-w4pbq2lb	213	14	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	213	15	.	.	.
cord-267897-w4pbq2lb	214	1	However	however	RB
cord-267897-w4pbq2lb	214	2	,	,	,
cord-267897-w4pbq2lb	214	3	as	as	IN
cord-267897-w4pbq2lb	214	4	the	the	DT
cord-267897-w4pbq2lb	214	5	proliferative	proliferative	JJ
cord-267897-w4pbq2lb	214	6	responses	response	NNS
cord-267897-w4pbq2lb	214	7	were	be	VBD
cord-267897-w4pbq2lb	214	8	inhibited	inhibit	VBN
cord-267897-w4pbq2lb	214	9	by	by	IN
cord-267897-w4pbq2lb	214	10	anti	anti	JJ
cord-267897-w4pbq2lb	214	11	-	-	JJ
cord-267897-w4pbq2lb	214	12	CD4	cd4	JJ
cord-267897-w4pbq2lb	214	13	antibody	antibody	NN
cord-267897-w4pbq2lb	214	14	,	,	,
cord-267897-w4pbq2lb	214	15	regardless	regardless	RB
cord-267897-w4pbq2lb	214	16	of	of	IN
cord-267897-w4pbq2lb	214	17	the	the	DT
cord-267897-w4pbq2lb	214	18	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	214	19	used	use	VBN
cord-267897-w4pbq2lb	214	20	,	,	,
cord-267897-w4pbq2lb	214	21	it	-PRON-	PRP
cord-267897-w4pbq2lb	214	22	indicated	indicate	VBD
cord-267897-w4pbq2lb	214	23	that	that	IN
cord-267897-w4pbq2lb	214	24	the	the	DT
cord-267897-w4pbq2lb	214	25	proliferating	proliferate	VBG
cord-267897-w4pbq2lb	214	26	CD4	CD4	NNP
cord-267897-w4pbq2lb	214	27	þ	þ	NNP
cord-267897-w4pbq2lb	214	28	T	t	NN
cord-267897-w4pbq2lb	214	29	cells	cell	NNS
cord-267897-w4pbq2lb	214	30	from	from	IN
cord-267897-w4pbq2lb	214	31	mice	mouse	NNS
cord-267897-w4pbq2lb	214	32	immunized	immunize	VBD
cord-267897-w4pbq2lb	214	33	using	use	VBG
cord-267897-w4pbq2lb	214	34	aluminum	aluminum	NN
cord-267897-w4pbq2lb	214	35	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	214	36	were	be	VBD
cord-267897-w4pbq2lb	214	37	of	of	IN
cord-267897-w4pbq2lb	214	38	the	the	DT
cord-267897-w4pbq2lb	214	39	Th2	Th2	NNP
cord-267897-w4pbq2lb	214	40	subset	subset	VBN
cord-267897-w4pbq2lb	214	41	.	.	.
cord-267897-w4pbq2lb	215	1	Lindblad	Lindblad	NNP
cord-267897-w4pbq2lb	215	2	and	and	CC
cord-267897-w4pbq2lb	215	3	coworkers	coworker	NNS
cord-267897-w4pbq2lb	215	4	31	31	CD
cord-267897-w4pbq2lb	215	5	found	find	VBD
cord-267897-w4pbq2lb	215	6	a	a	DT
cord-267897-w4pbq2lb	215	7	corresponding	corresponding	JJ
cord-267897-w4pbq2lb	215	8	profile	profile	NN
cord-267897-w4pbq2lb	215	9	in	in	IN
cord-267897-w4pbq2lb	215	10	C57BL/6J	C57BL/6J	NNP
cord-267897-w4pbq2lb	215	11	mice	mouse	NNS
cord-267897-w4pbq2lb	215	12	while	while	IN
cord-267897-w4pbq2lb	215	13	performing	perform	VBG
cord-267897-w4pbq2lb	215	14	reverse	reverse	JJ
cord-267897-w4pbq2lb	215	15	transcriptasepolymerase	transcriptasepolymerase	NN
cord-267897-w4pbq2lb	215	16	chain	chain	NN
cord-267897-w4pbq2lb	215	17	reaction	reaction	NN
cord-267897-w4pbq2lb	215	18	for	for	IN
cord-267897-w4pbq2lb	215	19	IL-4-and	IL-4-and	NNP
cord-267897-w4pbq2lb	215	20	IL-10-specific	IL-10-specific	NNP
cord-267897-w4pbq2lb	215	21	messenger	messenger	NN
cord-267897-w4pbq2lb	215	22	RNA	RNA	NNP
cord-267897-w4pbq2lb	215	23	(	(	-LRB-
cord-267897-w4pbq2lb	215	24	mRNA	mRNA	NNP
cord-267897-w4pbq2lb	215	25	)	)	-RRB-
cord-267897-w4pbq2lb	215	26	in	in	IN
cord-267897-w4pbq2lb	215	27	the	the	DT
cord-267897-w4pbq2lb	215	28	regional	regional	JJ
cord-267897-w4pbq2lb	215	29	draining	drain	VBG
cord-267897-w4pbq2lb	215	30	lymph	lymph	NN
cord-267897-w4pbq2lb	215	31	nodes	node	NNS
cord-267897-w4pbq2lb	215	32	at	at	IN
cord-267897-w4pbq2lb	215	33	day	day	NN
cord-267897-w4pbq2lb	215	34	7	7	CD
cord-267897-w4pbq2lb	215	35	following	follow	VBG
cord-267897-w4pbq2lb	215	36	vaccination	vaccination	NN
cord-267897-w4pbq2lb	215	37	with	with	IN
cord-267897-w4pbq2lb	215	38	aluminumadjuvanted	aluminumadjuvanted	JJ
cord-267897-w4pbq2lb	215	39	vaccine	vaccine	NN
cord-267897-w4pbq2lb	215	40	.	.	.
cord-267897-w4pbq2lb	216	1	It	-PRON-	PRP
cord-267897-w4pbq2lb	216	2	is	be	VBZ
cord-267897-w4pbq2lb	216	3	interesting	interesting	JJ
cord-267897-w4pbq2lb	216	4	that	that	IN
cord-267897-w4pbq2lb	216	5	a	a	DT
cord-267897-w4pbq2lb	216	6	complex	complex	NN
cord-267897-w4pbq2lb	216	7	between	between	IN
cord-267897-w4pbq2lb	216	8	Al(OH	al(oh	ADD
cord-267897-w4pbq2lb	216	9	)	)	-RRB-
cord-267897-w4pbq2lb	216	10	3	3	CD
cord-267897-w4pbq2lb	216	11	and	and	CC
cord-267897-w4pbq2lb	216	12	IL-12	IL-12	NNP
cord-267897-w4pbq2lb	216	13	(	(	-LRB-
cord-267897-w4pbq2lb	216	14	Al(OH	al(oh	NN
cord-267897-w4pbq2lb	216	15	)	)	-RRB-
cord-267897-w4pbq2lb	216	16	3	3	CD
cord-267897-w4pbq2lb	216	17	/IL-12	/il-12	NN
cord-267897-w4pbq2lb	216	18	)	)	-RRB-
cord-267897-w4pbq2lb	216	19	induced	induce	VBD
cord-267897-w4pbq2lb	216	20	a	a	DT
cord-267897-w4pbq2lb	216	21	Th1	th1	CD
cord-267897-w4pbq2lb	216	22	response	response	NN
cord-267897-w4pbq2lb	216	23	,	,	,
cord-267897-w4pbq2lb	216	24	rather	rather	RB
cord-267897-w4pbq2lb	216	25	than	than	IN
cord-267897-w4pbq2lb	216	26	a	a	DT
cord-267897-w4pbq2lb	216	27	Th2	th2	CD
cord-267897-w4pbq2lb	216	28	response	response	NN
cord-267897-w4pbq2lb	216	29	,	,	,
cord-267897-w4pbq2lb	216	30	when	when	WRB
cord-267897-w4pbq2lb	216	31	used	use	VBN
cord-267897-w4pbq2lb	216	32	as	as	IN
cord-267897-w4pbq2lb	216	33	an	an	DT
cord-267897-w4pbq2lb	216	34	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	216	35	79	79	CD
cord-267897-w4pbq2lb	216	36	and	and	CC
cord-267897-w4pbq2lb	216	37	the	the	DT
cord-267897-w4pbq2lb	216	38	Th1-promoting	th1-promoting	NN
cord-267897-w4pbq2lb	216	39	effect	effect	NN
cord-267897-w4pbq2lb	216	40	of	of	IN
cord-267897-w4pbq2lb	216	41	the	the	DT
cord-267897-w4pbq2lb	216	42	Al(OH	Al(OH	NNS
cord-267897-w4pbq2lb	216	43	)	)	-RRB-
cord-267897-w4pbq2lb	217	1	3	3	CD
cord-267897-w4pbq2lb	217	2	/IL-12	/il-12	NN
cord-267897-w4pbq2lb	217	3	complex	complex	NNP
cord-267897-w4pbq2lb	217	4	was	be	VBD
cord-267897-w4pbq2lb	217	5	greatly	greatly	RB
cord-267897-w4pbq2lb	217	6	augmented	augment	VBN
cord-267897-w4pbq2lb	217	7	by	by	IN
cord-267897-w4pbq2lb	217	8	the	the	DT
cord-267897-w4pbq2lb	217	9	coadministration	coadministration	NN
cord-267897-w4pbq2lb	217	10	of	of	IN
cord-267897-w4pbq2lb	217	11	exogenous	exogenous	JJ
cord-267897-w4pbq2lb	217	12	IL-18	IL-18	NNP
cord-267897-w4pbq2lb	217	13	.	.	.
cord-267897-w4pbq2lb	218	1	80	80	CD
cord-267897-w4pbq2lb	219	1	A	a	DT
cord-267897-w4pbq2lb	219	2	new	new	JJ
cord-267897-w4pbq2lb	219	3	line	line	NN
cord-267897-w4pbq2lb	219	4	of	of	IN
cord-267897-w4pbq2lb	219	5	research	research	NN
cord-267897-w4pbq2lb	219	6	was	be	VBD
cord-267897-w4pbq2lb	219	7	initiated	initiate	VBN
cord-267897-w4pbq2lb	219	8	with	with	IN
cord-267897-w4pbq2lb	219	9	the	the	DT
cord-267897-w4pbq2lb	219	10	introduction	introduction	NN
cord-267897-w4pbq2lb	219	11	of	of	IN
cord-267897-w4pbq2lb	219	12	gene	gene	NN
cord-267897-w4pbq2lb	219	13	knockout	knockout	NN
cord-267897-w4pbq2lb	219	14	mice	mouse	NNS
cord-267897-w4pbq2lb	219	15	.	.	.
cord-267897-w4pbq2lb	220	1	This	this	DT
cord-267897-w4pbq2lb	220	2	has	have	VBZ
cord-267897-w4pbq2lb	220	3	since	since	IN
cord-267897-w4pbq2lb	220	4	facilitated	facilitate	VBN
cord-267897-w4pbq2lb	220	5	the	the	DT
cord-267897-w4pbq2lb	220	6	study	study	NN
cord-267897-w4pbq2lb	220	7	of	of	IN
cord-267897-w4pbq2lb	220	8	the	the	DT
cord-267897-w4pbq2lb	220	9	significance	significance	NN
cord-267897-w4pbq2lb	220	10	of	of	IN
cord-267897-w4pbq2lb	220	11	interleukins	interleukin	NNS
cord-267897-w4pbq2lb	220	12	in	in	IN
cord-267897-w4pbq2lb	220	13	adjuvantmediated	adjuvantmediate	VBN
cord-267897-w4pbq2lb	220	14	immunostimulation	immunostimulation	NN
cord-267897-w4pbq2lb	220	15	.	.	.
cord-267897-w4pbq2lb	221	1	In	in	IN
cord-267897-w4pbq2lb	221	2	IL-4	IL-4	NNP
cord-267897-w4pbq2lb	221	3	gene	gene	NN
cord-267897-w4pbq2lb	221	4	knockout	knockout	NN
cord-267897-w4pbq2lb	221	5	mice	mice	NN
cord-267897-w4pbq2lb	221	6	,	,	,
cord-267897-w4pbq2lb	221	7	immunization	immunization	NN
cord-267897-w4pbq2lb	221	8	with	with	IN
cord-267897-w4pbq2lb	221	9	ovalbumin	ovalbumin	FW
cord-267897-w4pbq2lb	221	10	(	(	-LRB-
cord-267897-w4pbq2lb	221	11	OVA	ova	NN
cord-267897-w4pbq2lb	221	12	)	)	-RRB-
cord-267897-w4pbq2lb	222	1	þ	þ	LS
cord-267897-w4pbq2lb	222	2	Al(OH	al(oh	ADD
cord-267897-w4pbq2lb	222	3	)	)	-RRB-
cord-267897-w4pbq2lb	223	1	3	3	CD
cord-267897-w4pbq2lb	223	2	elicited	elicit	VBD
cord-267897-w4pbq2lb	223	3	IgG2a	igg2a	JJ
cord-267897-w4pbq2lb	223	4	titers	titer	NNS
cord-267897-w4pbq2lb	223	5	of	of	IN
cord-267897-w4pbq2lb	223	6	a	a	DT
cord-267897-w4pbq2lb	223	7	similar	similar	JJ
cord-267897-w4pbq2lb	223	8	magnitude	magnitude	NN
cord-267897-w4pbq2lb	223	9	as	as	IN
cord-267897-w4pbq2lb	223	10	when	when	WRB
cord-267897-w4pbq2lb	223	11	OVA	OVA	NNP
cord-267897-w4pbq2lb	223	12	was	be	VBD
cord-267897-w4pbq2lb	223	13	injected	inject	VBN
cord-267897-w4pbq2lb	223	14	together	together	RB
cord-267897-w4pbq2lb	223	15	with	with	IN
cord-267897-w4pbq2lb	223	16	Freund	Freund	NNP
cord-267897-w4pbq2lb	223	17	's	's	POS
cord-267897-w4pbq2lb	223	18	Complete	Complete	NNP
cord-267897-w4pbq2lb	223	19	Adjuvant	Adjuvant	NNP
cord-267897-w4pbq2lb	223	20	(	(	-LRB-
cord-267897-w4pbq2lb	223	21	FCA	FCA	NNP
cord-267897-w4pbq2lb	223	22	)	)	-RRB-
cord-267897-w4pbq2lb	223	23	.	.	.
cord-267897-w4pbq2lb	224	1	81	81	CD
cord-267897-w4pbq2lb	225	1	Interestingly	interestingly	RB
cord-267897-w4pbq2lb	225	2	,	,	,
cord-267897-w4pbq2lb	225	3	the	the	DT
cord-267897-w4pbq2lb	225	4	group	group	NN
cord-267897-w4pbq2lb	225	5	immunized	immunize	VBN
cord-267897-w4pbq2lb	225	6	with	with	IN
cord-267897-w4pbq2lb	225	7	OVAþ	OVAþ	NNP
cord-267897-w4pbq2lb	225	8	Al(OH	Al(OH	NNP
cord-267897-w4pbq2lb	225	9	)	)	-RRB-
cord-267897-w4pbq2lb	225	10	3	3	CD
cord-267897-w4pbq2lb	225	11	continued	continue	VBD
cord-267897-w4pbq2lb	225	12	to	to	TO
cord-267897-w4pbq2lb	225	13	produce	produce	VB
cord-267897-w4pbq2lb	225	14	IL-5	IL-5	NNP
cord-267897-w4pbq2lb	225	15	(	(	-LRB-
cord-267897-w4pbq2lb	225	16	a	a	DT
cord-267897-w4pbq2lb	225	17	cytokine	cytokine	NN
cord-267897-w4pbq2lb	225	18	normally	normally	RB
cord-267897-w4pbq2lb	225	19	associated	associate	VBN
cord-267897-w4pbq2lb	225	20	with	with	IN
cord-267897-w4pbq2lb	225	21	the	the	DT
cord-267897-w4pbq2lb	225	22	Th2	Th2	NNP
cord-267897-w4pbq2lb	225	23	profile	profile	NN
cord-267897-w4pbq2lb	225	24	)	)	-RRB-
cord-267897-w4pbq2lb	225	25	.	.	.
cord-267897-w4pbq2lb	226	1	In	in	IN
cord-267897-w4pbq2lb	226	2	contrast	contrast	NN
cord-267897-w4pbq2lb	226	3	,	,	,
cord-267897-w4pbq2lb	226	4	when	when	WRB
cord-267897-w4pbq2lb	226	5	the	the	DT
cord-267897-w4pbq2lb	226	6	IL-4	IL-4	NNP
cord-267897-w4pbq2lb	226	7	À	À	NNP
cord-267897-w4pbq2lb	226	8	/	/	SYM
cord-267897-w4pbq2lb	226	9	À	à	NN
cord-267897-w4pbq2lb	226	10	mice	mouse	NNS
cord-267897-w4pbq2lb	226	11	had	have	VBD
cord-267897-w4pbq2lb	226	12	been	be	VBN
cord-267897-w4pbq2lb	226	13	immunized	immunize	VBN
cord-267897-w4pbq2lb	226	14	using	use	VBG
cord-267897-w4pbq2lb	226	15	FCA	FCA	NNP
cord-267897-w4pbq2lb	226	16	a	a	DT
cord-267897-w4pbq2lb	226	17	similar	similar	JJ
cord-267897-w4pbq2lb	226	18	stimulation	stimulation	NN
cord-267897-w4pbq2lb	226	19	of	of	IN
cord-267897-w4pbq2lb	226	20	IL-5	IL-5	NNP
cord-267897-w4pbq2lb	226	21	was	be	VBD
cord-267897-w4pbq2lb	226	22	not	not	RB
cord-267897-w4pbq2lb	226	23	seen	see	VBN
cord-267897-w4pbq2lb	226	24	.	.	.
cord-267897-w4pbq2lb	227	1	This	this	DT
cord-267897-w4pbq2lb	227	2	is	be	VBZ
cord-267897-w4pbq2lb	227	3	in	in	IN
cord-267897-w4pbq2lb	227	4	support	support	NN
cord-267897-w4pbq2lb	227	5	of	of	IN
cord-267897-w4pbq2lb	227	6	the	the	DT
cord-267897-w4pbq2lb	227	7	idea	idea	NN
cord-267897-w4pbq2lb	227	8	that	that	IN
cord-267897-w4pbq2lb	227	9	the	the	DT
cord-267897-w4pbq2lb	227	10	major	major	JJ
cord-267897-w4pbq2lb	227	11	role	role	NN
cord-267897-w4pbq2lb	227	12	of	of	IN
cord-267897-w4pbq2lb	227	13	aluminum	aluminum	NN
cord-267897-w4pbq2lb	227	14	-	-	HYPH
cord-267897-w4pbq2lb	227	15	induced	induce	VBN
cord-267897-w4pbq2lb	227	16	IL-4	IL-4	NNP
cord-267897-w4pbq2lb	227	17	in	in	IN
cord-267897-w4pbq2lb	227	18	Th	th	RB
cord-267897-w4pbq2lb	227	19	-	-	HYPH
cord-267897-w4pbq2lb	227	20	subset	subset	JJ
cord-267897-w4pbq2lb	227	21	stimulation	stimulation	NN
cord-267897-w4pbq2lb	227	22	is	be	VBZ
cord-267897-w4pbq2lb	227	23	to	to	TO
cord-267897-w4pbq2lb	227	24	downregulate	downregulate	VB
cord-267897-w4pbq2lb	227	25	the	the	DT
cord-267897-w4pbq2lb	227	26	Th1	th1	CD
cord-267897-w4pbq2lb	227	27	response	response	NN
cord-267897-w4pbq2lb	227	28	.	.	.
cord-267897-w4pbq2lb	228	1	In	in	IN
cord-267897-w4pbq2lb	228	2	a	a	DT
cord-267897-w4pbq2lb	228	3	later	later	JJ
cord-267897-w4pbq2lb	228	4	study	study	NN
cord-267897-w4pbq2lb	228	5	,	,	,
cord-267897-w4pbq2lb	228	6	Jim	Jim	NNP
cord-267897-w4pbq2lb	228	7	Brewer	Brewer	NNP
cord-267897-w4pbq2lb	228	8	's	's	POS
cord-267897-w4pbq2lb	228	9	group	group	NN
cord-267897-w4pbq2lb	228	10	showed	show	VBD
cord-267897-w4pbq2lb	228	11	,	,	,
cord-267897-w4pbq2lb	228	12	using	use	VBG
cord-267897-w4pbq2lb	228	13	either	either	CC
cord-267897-w4pbq2lb	228	14	STAT6-or	STAT6-or	NNP
cord-267897-w4pbq2lb	228	15	IL-4Ra	il-4ra	NN
cord-267897-w4pbq2lb	228	16	-	-	HYPH
cord-267897-w4pbq2lb	228	17	deficient	deficient	JJ
cord-267897-w4pbq2lb	228	18	mice	mouse	NNS
cord-267897-w4pbq2lb	228	19	,	,	,
cord-267897-w4pbq2lb	228	20	that	that	IN
cord-267897-w4pbq2lb	228	21	although	although	IN
cord-267897-w4pbq2lb	228	22	these	these	DT
cord-267897-w4pbq2lb	228	23	mice	mouse	NNS
cord-267897-w4pbq2lb	228	24	were	be	VBD
cord-267897-w4pbq2lb	228	25	unable	unable	JJ
cord-267897-w4pbq2lb	228	26	to	to	TO
cord-267897-w4pbq2lb	228	27	further	further	RB
cord-267897-w4pbq2lb	228	28	process	process	VB
cord-267897-w4pbq2lb	228	29	an	an	DT
cord-267897-w4pbq2lb	228	30	IL-4-mediated	il-4-mediated	CD
cord-267897-w4pbq2lb	228	31	signal	signal	NN
cord-267897-w4pbq2lb	228	32	,	,	,
cord-267897-w4pbq2lb	228	33	the	the	DT
cord-267897-w4pbq2lb	228	34	ability	ability	NN
cord-267897-w4pbq2lb	228	35	of	of	IN
cord-267897-w4pbq2lb	228	36	aluminum	aluminum	NN
cord-267897-w4pbq2lb	228	37	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	228	38	to	to	TO
cord-267897-w4pbq2lb	228	39	induce	induce	VB
cord-267897-w4pbq2lb	228	40	IL-4	IL-4	NNP
cord-267897-w4pbq2lb	228	41	was	be	VBD
cord-267897-w4pbq2lb	228	42	not	not	RB
cord-267897-w4pbq2lb	228	43	abrogated	abrogate	VBN
cord-267897-w4pbq2lb	228	44	.	.	.
cord-267897-w4pbq2lb	229	1	Higher	high	JJR
cord-267897-w4pbq2lb	229	2	levels	level	NNS
cord-267897-w4pbq2lb	229	3	of	of	IN
cord-267897-w4pbq2lb	229	4	IL-4	IL-4	NNP
cord-267897-w4pbq2lb	229	5	were	be	VBD
cord-267897-w4pbq2lb	229	6	found	find	VBN
cord-267897-w4pbq2lb	229	7	in	in	IN
cord-267897-w4pbq2lb	229	8	IL-4Ra	IL-4Ra	NNP
cord-267897-w4pbq2lb	229	9	À	à	NN
cord-267897-w4pbq2lb	229	10	/	/	SYM
cord-267897-w4pbq2lb	229	11	À	à	NN
cord-267897-w4pbq2lb	229	12	mice	mouse	NNS
cord-267897-w4pbq2lb	229	13	than	than	IN
cord-267897-w4pbq2lb	229	14	in	in	IN
cord-267897-w4pbq2lb	229	15	the	the	DT
cord-267897-w4pbq2lb	229	16	wild	wild	JJ
cord-267897-w4pbq2lb	229	17	-	-	HYPH
cord-267897-w4pbq2lb	229	18	type	type	NN
cord-267897-w4pbq2lb	229	19	mice	mouse	NNS
cord-267897-w4pbq2lb	229	20	.	.	.
cord-267897-w4pbq2lb	230	1	It	-PRON-	PRP
cord-267897-w4pbq2lb	230	2	has	have	VBZ
cord-267897-w4pbq2lb	230	3	been	be	VBN
cord-267897-w4pbq2lb	230	4	suggested	suggest	VBN
cord-267897-w4pbq2lb	230	5	that	that	IN
cord-267897-w4pbq2lb	230	6	the	the	DT
cord-267897-w4pbq2lb	230	7	Th2	th2	CD
cord-267897-w4pbq2lb	230	8	stimulation	stimulation	NN
cord-267897-w4pbq2lb	230	9	in	in	IN
cord-267897-w4pbq2lb	230	10	IL-4	IL-4	NNP
cord-267897-w4pbq2lb	230	11	À	À	NNP
cord-267897-w4pbq2lb	230	12	/	/	SYM
cord-267897-w4pbq2lb	230	13	À	à	NN
cord-267897-w4pbq2lb	230	14	mice	mouse	NNS
cord-267897-w4pbq2lb	230	15	could	could	MD
cord-267897-w4pbq2lb	230	16	be	be	VB
cord-267897-w4pbq2lb	230	17	due	due	JJ
cord-267897-w4pbq2lb	230	18	to	to	IN
cord-267897-w4pbq2lb	230	19	overlapping	overlap	VBG
cord-267897-w4pbq2lb	230	20	responses	response	NNS
cord-267897-w4pbq2lb	230	21	of	of	IN
cord-267897-w4pbq2lb	230	22	IL-4	IL-4	NNP
cord-267897-w4pbq2lb	230	23	and	and	CC
cord-267897-w4pbq2lb	230	24	IL-13	IL-13	NNP
cord-267897-w4pbq2lb	230	25	,	,	,
cord-267897-w4pbq2lb	230	26	since	since	IN
cord-267897-w4pbq2lb	230	27	they	-PRON-	PRP
cord-267897-w4pbq2lb	230	28	both	both	DT
cord-267897-w4pbq2lb	230	29	utilize	utilize	VBP
cord-267897-w4pbq2lb	230	30	a	a	DT
cord-267897-w4pbq2lb	230	31	common	common	JJ
cord-267897-w4pbq2lb	230	32	signaling	signal	VBG
cord-267897-w4pbq2lb	230	33	pathway	pathway	NN
cord-267897-w4pbq2lb	230	34	via	via	IN
cord-267897-w4pbq2lb	230	35	the	the	DT
cord-267897-w4pbq2lb	230	36	IL-4	IL-4	NNP
cord-267897-w4pbq2lb	230	37	receptor	receptor	NN
cord-267897-w4pbq2lb	230	38	.	.	.
cord-267897-w4pbq2lb	231	1	However	however	RB
cord-267897-w4pbq2lb	231	2	,	,	,
cord-267897-w4pbq2lb	231	3	they	-PRON-	PRP
cord-267897-w4pbq2lb	231	4	concluded	conclude	VBD
cord-267897-w4pbq2lb	231	5	that	that	IN
cord-267897-w4pbq2lb	231	6	the	the	DT
cord-267897-w4pbq2lb	231	7	Th2	th2	CD
cord-267897-w4pbq2lb	231	8	response	response	NN
cord-267897-w4pbq2lb	231	9	could	could	MD
cord-267897-w4pbq2lb	231	10	not	not	RB
cord-267897-w4pbq2lb	231	11	be	be	VB
cord-267897-w4pbq2lb	231	12	due	due	JJ
cord-267897-w4pbq2lb	231	13	to	to	IN
cord-267897-w4pbq2lb	231	14	IL-13	IL-13	NNP
cord-267897-w4pbq2lb	231	15	,	,	,
cord-267897-w4pbq2lb	231	16	since	since	IN
cord-267897-w4pbq2lb	231	17	the	the	DT
cord-267897-w4pbq2lb	231	18	IL-13	IL-13	NNP
cord-267897-w4pbq2lb	231	19	response	response	NN
cord-267897-w4pbq2lb	231	20	too	too	RB
cord-267897-w4pbq2lb	231	21	is	be	VBZ
cord-267897-w4pbq2lb	231	22	impaired	impair	VBN
cord-267897-w4pbq2lb	231	23	in	in	IN
cord-267897-w4pbq2lb	231	24	STAT6-or	STAT6-or	NNP
cord-267897-w4pbq2lb	231	25	IL-4Ra	IL-4Ra	VBN
cord-267897-w4pbq2lb	231	26	-	-	HYPH
cord-267897-w4pbq2lb	231	27	deficient	deficient	JJ
cord-267897-w4pbq2lb	231	28	mice	mouse	NNS
cord-267897-w4pbq2lb	231	29	.	.	.
cord-267897-w4pbq2lb	232	1	82	82	CD
cord-267897-w4pbq2lb	233	1	The	the	DT
cord-267897-w4pbq2lb	233	2	role	role	NN
cord-267897-w4pbq2lb	233	3	of	of	IN
cord-267897-w4pbq2lb	233	4	IL-18	IL-18	NNP
cord-267897-w4pbq2lb	233	5	in	in	IN
cord-267897-w4pbq2lb	233	6	the	the	DT
cord-267897-w4pbq2lb	233	7	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	233	8	activity	activity	NN
cord-267897-w4pbq2lb	233	9	of	of	IN
cord-267897-w4pbq2lb	233	10	aluminum	aluminum	NN
cord-267897-w4pbq2lb	233	11	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	233	12	and	and	CC
cord-267897-w4pbq2lb	233	13	its	-PRON-	PRP$
cord-267897-w4pbq2lb	233	14	effect	effect	NN
cord-267897-w4pbq2lb	233	15	on	on	IN
cord-267897-w4pbq2lb	233	16	Th2	th2	CD
cord-267897-w4pbq2lb	233	17	induction	induction	NN
cord-267897-w4pbq2lb	233	18	was	be	VBD
cord-267897-w4pbq2lb	233	19	studied	study	VBN
cord-267897-w4pbq2lb	233	20	by	by	IN
cord-267897-w4pbq2lb	233	21	Brewers	Brewers	NNPS
cord-267897-w4pbq2lb	233	22	group	group	NN
cord-267897-w4pbq2lb	233	23	.	.	.
cord-267897-w4pbq2lb	234	1	80	80	CD
cord-267897-w4pbq2lb	235	1	They	-PRON-	PRP
cord-267897-w4pbq2lb	235	2	demonstrated	demonstrate	VBD
cord-267897-w4pbq2lb	235	3	that	that	IN
cord-267897-w4pbq2lb	235	4	IL-18deficient	IL-18deficient	NNP
cord-267897-w4pbq2lb	235	5	mice	mouse	NNS
cord-267897-w4pbq2lb	235	6	immunized	immunize	VBN
cord-267897-w4pbq2lb	235	7	with	with	IN
cord-267897-w4pbq2lb	235	8	OVA	OVA	NNP
cord-267897-w4pbq2lb	235	9	þ	þ	NNP
cord-267897-w4pbq2lb	235	10	Al(OH	al(oh	ADD
cord-267897-w4pbq2lb	235	11	)	)	-RRB-
cord-267897-w4pbq2lb	235	12	3	3	CD
cord-267897-w4pbq2lb	235	13	had	have	VBD
cord-267897-w4pbq2lb	235	14	reduced	reduce	VBN
cord-267897-w4pbq2lb	235	15	IL-4	IL-4	NNP
cord-267897-w4pbq2lb	235	16	production	production	NN
cord-267897-w4pbq2lb	235	17	in	in	IN
cord-267897-w4pbq2lb	235	18	lymph	lymph	NN
cord-267897-w4pbq2lb	235	19	node	node	NN
cord-267897-w4pbq2lb	235	20	cells	cell	NNS
cord-267897-w4pbq2lb	235	21	compared	compare	VBN
cord-267897-w4pbq2lb	235	22	with	with	IN
cord-267897-w4pbq2lb	235	23	wild	wild	JJ
cord-267897-w4pbq2lb	235	24	-	-	HYPH
cord-267897-w4pbq2lb	235	25	type	type	NN
cord-267897-w4pbq2lb	235	26	mice	mouse	NNS
cord-267897-w4pbq2lb	235	27	.	.	.
cord-267897-w4pbq2lb	236	1	However	however	RB
cord-267897-w4pbq2lb	236	2	,	,	,
cord-267897-w4pbq2lb	236	3	if	if	IN
cord-267897-w4pbq2lb	236	4	they	-PRON-	PRP
cord-267897-w4pbq2lb	236	5	added	add	VBD
cord-267897-w4pbq2lb	236	6	exogenous	exogenous	JJ
cord-267897-w4pbq2lb	236	7	IL-18	IL-18	NNP
cord-267897-w4pbq2lb	236	8	,	,	,
cord-267897-w4pbq2lb	236	9	it	-PRON-	PRP
cord-267897-w4pbq2lb	236	10	did	do	VBD
cord-267897-w4pbq2lb	236	11	not	not	RB
cord-267897-w4pbq2lb	236	12	further	further	RB
cord-267897-w4pbq2lb	236	13	enhance	enhance	VB
cord-267897-w4pbq2lb	236	14	the	the	DT
cord-267897-w4pbq2lb	236	15	aluminum	aluminum	NN
cord-267897-w4pbq2lb	236	16	-	-	HYPH
cord-267897-w4pbq2lb	236	17	induced	induce	VBN
cord-267897-w4pbq2lb	236	18	Th2	th2	CD
cord-267897-w4pbq2lb	236	19	response	response	NN
cord-267897-w4pbq2lb	236	20	.	.	.
cord-267897-w4pbq2lb	237	1	Although	although	IN
cord-267897-w4pbq2lb	237	2	the	the	DT
cord-267897-w4pbq2lb	237	3	aluminum	aluminum	NN
cord-267897-w4pbq2lb	237	4	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	237	5	led	lead	VBD
cord-267897-w4pbq2lb	237	6	to	to	IN
cord-267897-w4pbq2lb	237	7	reduced	reduce	VBN
cord-267897-w4pbq2lb	237	8	IL-4	IL-4	NNP
cord-267897-w4pbq2lb	237	9	production	production	NN
cord-267897-w4pbq2lb	237	10	in	in	IN
cord-267897-w4pbq2lb	237	11	IL-18	IL-18	NNP
cord-267897-w4pbq2lb	237	12	À	à	NN
cord-267897-w4pbq2lb	237	13	/	/	SYM
cord-267897-w4pbq2lb	237	14	À	à	NN
cord-267897-w4pbq2lb	237	15	mice	mouse	NNS
cord-267897-w4pbq2lb	237	16	,	,	,
cord-267897-w4pbq2lb	237	17	this	this	DT
cord-267897-w4pbq2lb	237	18	was	be	VBD
cord-267897-w4pbq2lb	237	19	not	not	RB
cord-267897-w4pbq2lb	237	20	accompanied	accompany	VBN
cord-267897-w4pbq2lb	237	21	by	by	IN
cord-267897-w4pbq2lb	237	22	a	a	DT
cord-267897-w4pbq2lb	237	23	reduced	reduce	VBN
cord-267897-w4pbq2lb	237	24	level	level	NN
cord-267897-w4pbq2lb	237	25	of	of	IN
cord-267897-w4pbq2lb	237	26	serum	serum	NN
cord-267897-w4pbq2lb	237	27	IgG1	igg1	NN
cord-267897-w4pbq2lb	237	28	.	.	.
cord-267897-w4pbq2lb	238	1	Apparently	apparently	RB
cord-267897-w4pbq2lb	238	2	,	,	,
cord-267897-w4pbq2lb	238	3	there	there	EX
cord-267897-w4pbq2lb	238	4	is	be	VBZ
cord-267897-w4pbq2lb	238	5	poor	poor	JJ
cord-267897-w4pbq2lb	238	6	correlation	correlation	NN
cord-267897-w4pbq2lb	238	7	between	between	IN
cord-267897-w4pbq2lb	238	8	this	this	DT
cord-267897-w4pbq2lb	238	9	particular	particular	JJ
cord-267897-w4pbq2lb	238	10	antibody	antibody	NN
cord-267897-w4pbq2lb	238	11	subclass	subclass	NN
cord-267897-w4pbq2lb	238	12	and	and	CC
cord-267897-w4pbq2lb	238	13	IL-4	IL-4	NNP
cord-267897-w4pbq2lb	238	14	production	production	NN
cord-267897-w4pbq2lb	238	15	.	.	.
cord-267897-w4pbq2lb	239	1	With	with	IN
cord-267897-w4pbq2lb	239	2	calcium	calcium	NN
cord-267897-w4pbq2lb	239	3	phosphate	phosphate	NN
cord-267897-w4pbq2lb	239	4	no	no	DT
cord-267897-w4pbq2lb	239	5	cytokine	cytokine	NN
cord-267897-w4pbq2lb	239	6	data	datum	NNS
cord-267897-w4pbq2lb	239	7	are	be	VBP
cord-267897-w4pbq2lb	239	8	yet	yet	RB
cord-267897-w4pbq2lb	239	9	found	find	VBN
cord-267897-w4pbq2lb	239	10	in	in	IN
cord-267897-w4pbq2lb	239	11	the	the	DT
cord-267897-w4pbq2lb	239	12	literature	literature	NN
cord-267897-w4pbq2lb	239	13	.	.	.
cord-267897-w4pbq2lb	240	1	It	-PRON-	PRP
cord-267897-w4pbq2lb	240	2	is	be	VBZ
cord-267897-w4pbq2lb	240	3	not	not	RB
cord-267897-w4pbq2lb	240	4	yet	yet	RB
cord-267897-w4pbq2lb	240	5	possible	possible	JJ
cord-267897-w4pbq2lb	240	6	to	to	TO
cord-267897-w4pbq2lb	240	7	investigate	investigate	VB
cord-267897-w4pbq2lb	240	8	surface	surface	NN
cord-267897-w4pbq2lb	240	9	marker	marker	NN
cord-267897-w4pbq2lb	240	10	differentiation	differentiation	NN
cord-267897-w4pbq2lb	240	11	over	over	IN
cord-267897-w4pbq2lb	240	12	time	time	NN
cord-267897-w4pbq2lb	240	13	of	of	IN
cord-267897-w4pbq2lb	240	14	cell	cell	NN
cord-267897-w4pbq2lb	240	15	populations	population	NNS
cord-267897-w4pbq2lb	240	16	in	in	IN
cord-267897-w4pbq2lb	240	17	vivo	vivo	NN
cord-267897-w4pbq2lb	240	18	due	due	IN
cord-267897-w4pbq2lb	240	19	to	to	IN
cord-267897-w4pbq2lb	240	20	the	the	DT
cord-267897-w4pbq2lb	240	21	biological	biological	JJ
cord-267897-w4pbq2lb	240	22	complexity	complexity	NN
cord-267897-w4pbq2lb	240	23	of	of	IN
cord-267897-w4pbq2lb	240	24	living	live	VBG
cord-267897-w4pbq2lb	240	25	organisms	organism	NNS
cord-267897-w4pbq2lb	240	26	.	.	.
cord-267897-w4pbq2lb	241	1	However	however	RB
cord-267897-w4pbq2lb	241	2	,	,	,
cord-267897-w4pbq2lb	241	3	in	in	IN
cord-267897-w4pbq2lb	241	4	vitro	vitro	FW
cord-267897-w4pbq2lb	241	5	models	model	NNS
cord-267897-w4pbq2lb	241	6	may	may	MD
cord-267897-w4pbq2lb	241	7	lead	lead	VB
cord-267897-w4pbq2lb	241	8	to	to	IN
cord-267897-w4pbq2lb	241	9	observations	observation	NNS
cord-267897-w4pbq2lb	241	10	the	the	DT
cord-267897-w4pbq2lb	241	11	validity	validity	NN
cord-267897-w4pbq2lb	241	12	of	of	IN
cord-267897-w4pbq2lb	241	13	which	which	WDT
cord-267897-w4pbq2lb	241	14	may	may	MD
cord-267897-w4pbq2lb	241	15	later	later	RB
cord-267897-w4pbq2lb	241	16	be	be	VB
cord-267897-w4pbq2lb	241	17	challengedd	challengedd	VBN
cord-267897-w4pbq2lb	241	18	with	with	IN
cord-267897-w4pbq2lb	241	19	all	all	DT
cord-267897-w4pbq2lb	241	20	due	due	JJ
cord-267897-w4pbq2lb	241	21	care	care	NN
cord-267897-w4pbq2lb	241	22	takendby	takendby	NN
cord-267897-w4pbq2lb	241	23	in	in	IN
cord-267897-w4pbq2lb	241	24	vivo	vivo	NN
cord-267897-w4pbq2lb	241	25	control	control	NN
cord-267897-w4pbq2lb	241	26	experiments	experiment	NNS
cord-267897-w4pbq2lb	241	27	.	.	.
cord-267897-w4pbq2lb	242	1	Ulanova	Ulanova	NNP
cord-267897-w4pbq2lb	242	2	et	et	NNP
cord-267897-w4pbq2lb	242	3	al	al	NNP
cord-267897-w4pbq2lb	242	4	.	.	.
cord-267897-w4pbq2lb	243	1	83	83	CD
cord-267897-w4pbq2lb	243	2	were	be	VBD
cord-267897-w4pbq2lb	243	3	among	among	IN
cord-267897-w4pbq2lb	243	4	the	the	DT
cord-267897-w4pbq2lb	243	5	first	first	JJ
cord-267897-w4pbq2lb	243	6	to	to	TO
cord-267897-w4pbq2lb	243	7	carry	carry	VB
cord-267897-w4pbq2lb	243	8	out	out	RP
cord-267897-w4pbq2lb	243	9	systematic	systematic	JJ
cord-267897-w4pbq2lb	243	10	studies	study	NNS
cord-267897-w4pbq2lb	243	11	on	on	IN
cord-267897-w4pbq2lb	243	12	the	the	DT
cord-267897-w4pbq2lb	243	13	direct	direct	JJ
cord-267897-w4pbq2lb	243	14	effect	effect	NN
cord-267897-w4pbq2lb	243	15	of	of	IN
cord-267897-w4pbq2lb	243	16	aluminum	aluminum	NN
cord-267897-w4pbq2lb	243	17	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	243	18	in	in	IN
cord-267897-w4pbq2lb	243	19	cultures	culture	NNS
cord-267897-w4pbq2lb	243	20	of	of	IN
cord-267897-w4pbq2lb	243	21	human	human	JJ
cord-267897-w4pbq2lb	243	22	peripheral	peripheral	JJ
cord-267897-w4pbq2lb	243	23	blood	blood	NN
cord-267897-w4pbq2lb	243	24	mononuclear	mononuclear	NN
cord-267897-w4pbq2lb	243	25	cells	cell	NNS
cord-267897-w4pbq2lb	243	26	(	(	-LRB-
cord-267897-w4pbq2lb	243	27	PBMCs	pbmc	NNS
cord-267897-w4pbq2lb	243	28	)	)	-RRB-
cord-267897-w4pbq2lb	243	29	.	.	.
cord-267897-w4pbq2lb	244	1	They	-PRON-	PRP
cord-267897-w4pbq2lb	244	2	found	find	VBD
cord-267897-w4pbq2lb	244	3	an	an	DT
cord-267897-w4pbq2lb	244	4	increase	increase	NN
cord-267897-w4pbq2lb	244	5	in	in	IN
cord-267897-w4pbq2lb	244	6	the	the	DT
cord-267897-w4pbq2lb	244	7	expression	expression	NN
cord-267897-w4pbq2lb	244	8	of	of	IN
cord-267897-w4pbq2lb	244	9	costimulatory	costimulatory	NN
cord-267897-w4pbq2lb	244	10	and	and	CC
cord-267897-w4pbq2lb	244	11	adhesion	adhesion	NN
cord-267897-w4pbq2lb	244	12	molecules	molecule	NNS
cord-267897-w4pbq2lb	244	13	:	:	:
cord-267897-w4pbq2lb	244	14	MHC	MHC	NNP
cord-267897-w4pbq2lb	244	15	class	class	NN
cord-267897-w4pbq2lb	244	16	II	II	NNP
cord-267897-w4pbq2lb	244	17	,	,	,
cord-267897-w4pbq2lb	244	18	CD40	CD40	NNP
cord-267897-w4pbq2lb	244	19	,	,	,
cord-267897-w4pbq2lb	244	20	CD54	CD54	NNP
cord-267897-w4pbq2lb	244	21	(	(	-LRB-
cord-267897-w4pbq2lb	244	22	formerly	formerly	RB
cord-267897-w4pbq2lb	244	23	known	know	VBN
cord-267897-w4pbq2lb	244	24	as	as	IN
cord-267897-w4pbq2lb	244	25	intercellular	intercellular	JJ
cord-267897-w4pbq2lb	244	26	adhesion	adhesion	NN
cord-267897-w4pbq2lb	244	27	molecule	molecule	NN
cord-267897-w4pbq2lb	244	28	1	1	CD
cord-267897-w4pbq2lb	244	29	,	,	,
cord-267897-w4pbq2lb	244	30	or	or	CC
cord-267897-w4pbq2lb	244	31	ICAM-1	ICAM-1	NNP
cord-267897-w4pbq2lb	244	32	)	)	-RRB-
cord-267897-w4pbq2lb	244	33	,	,	,
cord-267897-w4pbq2lb	244	34	CD58	CD58	NNP
cord-267897-w4pbq2lb	244	35	(	(	-LRB-
cord-267897-w4pbq2lb	244	36	formerly	formerly	RB
cord-267897-w4pbq2lb	244	37	known	know	VBN
cord-267897-w4pbq2lb	244	38	as	as	IN
cord-267897-w4pbq2lb	244	39	lymphocyte	lymphocyte	NN
cord-267897-w4pbq2lb	244	40	function	function	NN
cord-267897-w4pbq2lb	244	41	-	-	HYPH
cord-267897-w4pbq2lb	244	42	associated	associate	VBN
cord-267897-w4pbq2lb	244	43	antigen	antigen	NN
cord-267897-w4pbq2lb	244	44	3	3	CD
cord-267897-w4pbq2lb	244	45	or	or	CC
cord-267897-w4pbq2lb	244	46	LFA-3	LFA-3	NNP
cord-267897-w4pbq2lb	244	47	)	)	-RRB-
cord-267897-w4pbq2lb	244	48	,	,	,
cord-267897-w4pbq2lb	244	49	CD83	CD83	NNP
cord-267897-w4pbq2lb	244	50	(	(	-LRB-
cord-267897-w4pbq2lb	244	51	maturation	maturation	NN
cord-267897-w4pbq2lb	244	52	marker	marker	NN
cord-267897-w4pbq2lb	244	53	)	)	-RRB-
cord-267897-w4pbq2lb	244	54	,	,	,
cord-267897-w4pbq2lb	244	55	and	and	CC
cord-267897-w4pbq2lb	244	56	CD86	CD86	NNP
cord-267897-w4pbq2lb	244	57	(	(	-LRB-
cord-267897-w4pbq2lb	244	58	formerly	formerly	RB
cord-267897-w4pbq2lb	244	59	known	know	VBN
cord-267897-w4pbq2lb	244	60	as	as	IN
cord-267897-w4pbq2lb	244	61	B7	b7	NN
cord-267897-w4pbq2lb	244	62	-	-	HYPH
cord-267897-w4pbq2lb	244	63	2	2	CD
cord-267897-w4pbq2lb	244	64	)	)	-RRB-
cord-267897-w4pbq2lb	244	65	on	on	IN
cord-267897-w4pbq2lb	244	66	the	the	DT
cord-267897-w4pbq2lb	244	67	monocytes	monocyte	NNS
cord-267897-w4pbq2lb	244	68	as	as	RB
cord-267897-w4pbq2lb	244	69	well	well	RB
cord-267897-w4pbq2lb	244	70	as	as	IN
cord-267897-w4pbq2lb	244	71	an	an	DT
cord-267897-w4pbq2lb	244	72	increase	increase	NN
cord-267897-w4pbq2lb	244	73	of	of	IN
cord-267897-w4pbq2lb	244	74	mRNA	mrna	NN
cord-267897-w4pbq2lb	244	75	for	for	IN
cord-267897-w4pbq2lb	244	76	IL-4	IL-4	NNP
cord-267897-w4pbq2lb	244	77	.	.	.
cord-267897-w4pbq2lb	245	1	However	however	RB
cord-267897-w4pbq2lb	245	2	,	,	,
cord-267897-w4pbq2lb	245	3	in	in	IN
cord-267897-w4pbq2lb	245	4	the	the	DT
cord-267897-w4pbq2lb	245	5	presence	presence	NN
cord-267897-w4pbq2lb	245	6	of	of	IN
cord-267897-w4pbq2lb	245	7	anti	anti	JJ
cord-267897-w4pbq2lb	245	8	-	-	JJ
cord-267897-w4pbq2lb	245	9	IL-4	il-4	JJ
cord-267897-w4pbq2lb	245	10	antibody	antibody	NN
cord-267897-w4pbq2lb	245	11	or	or	CC
cord-267897-w4pbq2lb	245	12	in	in	IN
cord-267897-w4pbq2lb	245	13	highly	highly	RB
cord-267897-w4pbq2lb	245	14	purified	purify	VBN
cord-267897-w4pbq2lb	245	15	monocyte	monocyte	NNP
cord-267897-w4pbq2lb	245	16	cultures	culture	NNS
cord-267897-w4pbq2lb	245	17	(	(	-LRB-
cord-267897-w4pbq2lb	245	18	i.e.	i.e.	FW
cord-267897-w4pbq2lb	245	19	,	,	,
cord-267897-w4pbq2lb	245	20	depleted	deplete	VBN
cord-267897-w4pbq2lb	245	21	of	of	IN
cord-267897-w4pbq2lb	245	22	CD4	CD4	NNP
cord-267897-w4pbq2lb	245	23	þ	þ	NNP
cord-267897-w4pbq2lb	245	24	T	T	NNP
cord-267897-w4pbq2lb	245	25	cells	cell	NNS
cord-267897-w4pbq2lb	245	26	)	)	-RRB-
cord-267897-w4pbq2lb	245	27	there	there	EX
cord-267897-w4pbq2lb	245	28	was	be	VBD
cord-267897-w4pbq2lb	245	29	no	no	DT
cord-267897-w4pbq2lb	245	30	increase	increase	NN
cord-267897-w4pbq2lb	245	31	in	in	IN
cord-267897-w4pbq2lb	245	32	MHC	MHC	NNP
cord-267897-w4pbq2lb	245	33	class	class	NN
cord-267897-w4pbq2lb	245	34	II	II	NNP
cord-267897-w4pbq2lb	245	35	expression	expression	NN
cord-267897-w4pbq2lb	245	36	.	.	.
cord-267897-w4pbq2lb	246	1	So	so	RB
cord-267897-w4pbq2lb	246	2	,	,	,
cord-267897-w4pbq2lb	246	3	apparently	apparently	RB
cord-267897-w4pbq2lb	246	4	,	,	,
cord-267897-w4pbq2lb	246	5	aluminum	aluminum	NN
cord-267897-w4pbq2lb	246	6	adjuvanteinduced	adjuvanteinduce	VBN
cord-267897-w4pbq2lb	246	7	monocyte	monocyte	NNP
cord-267897-w4pbq2lb	246	8	-	-	HYPH
cord-267897-w4pbq2lb	246	9	derived	derive	VBN
cord-267897-w4pbq2lb	246	10	cytokines	cytokine	NNS
cord-267897-w4pbq2lb	246	11	stimulated	stimulate	VBD
cord-267897-w4pbq2lb	246	12	CD4	CD4	NNP
cord-267897-w4pbq2lb	246	13	þ	þ	NNP
cord-267897-w4pbq2lb	246	14	T	t	NN
cord-267897-w4pbq2lb	246	15	cells	cell	NNS
cord-267897-w4pbq2lb	246	16	to	to	TO
cord-267897-w4pbq2lb	246	17	secrete	secrete	VB
cord-267897-w4pbq2lb	246	18	IL-4	IL-4	NNP
cord-267897-w4pbq2lb	246	19	,	,	,
cord-267897-w4pbq2lb	246	20	which	which	WDT
cord-267897-w4pbq2lb	246	21	in	in	IN
cord-267897-w4pbq2lb	246	22	turn	turn	NN
cord-267897-w4pbq2lb	246	23	stimulated	stimulate	VBD
cord-267897-w4pbq2lb	246	24	MHC	MHC	NNP
cord-267897-w4pbq2lb	246	25	class	class	NN
cord-267897-w4pbq2lb	246	26	II	ii	CD
cord-267897-w4pbq2lb	246	27	expression	expression	NN
cord-267897-w4pbq2lb	246	28	on	on	IN
cord-267897-w4pbq2lb	246	29	the	the	DT
cord-267897-w4pbq2lb	246	30	monocyte	monocyte	NNP
cord-267897-w4pbq2lb	246	31	surface	surface	NN
cord-267897-w4pbq2lb	246	32	.	.	.
cord-267897-w4pbq2lb	247	1	Rimaniol	Rimaniol	NNP
cord-267897-w4pbq2lb	247	2	and	and	CC
cord-267897-w4pbq2lb	247	3	coworkers	coworker	NNS
cord-267897-w4pbq2lb	247	4	84	84	CD
cord-267897-w4pbq2lb	247	5	cultivated	cultivate	VBN
cord-267897-w4pbq2lb	247	6	human	human	JJ
cord-267897-w4pbq2lb	247	7	monocytes	monocyte	NNS
cord-267897-w4pbq2lb	247	8	(	(	-LRB-
cord-267897-w4pbq2lb	247	9	PBMC	PBMC	NNP
cord-267897-w4pbq2lb	247	10	)	)	-RRB-
cord-267897-w4pbq2lb	247	11	in	in	IN
cord-267897-w4pbq2lb	247	12	medium	medium	NN
cord-267897-w4pbq2lb	247	13	alone	alone	RB
cord-267897-w4pbq2lb	247	14	or	or	CC
cord-267897-w4pbq2lb	247	15	medium	medium	JJ
cord-267897-w4pbq2lb	247	16	containing	contain	VBG
cord-267897-w4pbq2lb	247	17	aluminum	aluminum	NN
cord-267897-w4pbq2lb	247	18	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	247	19	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	247	20	and	and	CC
cord-267897-w4pbq2lb	247	21	observed	observe	VBD
cord-267897-w4pbq2lb	247	22	the	the	DT
cord-267897-w4pbq2lb	247	23	phenotypic	phenotypic	JJ
cord-267897-w4pbq2lb	247	24	macrophage	macrophage	NN
cord-267897-w4pbq2lb	247	25	changes	change	NNS
cord-267897-w4pbq2lb	247	26	.	.	.
cord-267897-w4pbq2lb	248	1	The	the	DT
cord-267897-w4pbq2lb	248	2	changes	change	NNS
cord-267897-w4pbq2lb	248	3	encountered	encounter	VBD
cord-267897-w4pbq2lb	248	4	involved	involve	VBD
cord-267897-w4pbq2lb	248	5	significant	significant	JJ
cord-267897-w4pbq2lb	248	6	upregulation	upregulation	NN
cord-267897-w4pbq2lb	248	7	of	of	IN
cord-267897-w4pbq2lb	248	8	HLA	HLA	NNP
cord-267897-w4pbq2lb	248	9	-	-	HYPH
cord-267897-w4pbq2lb	248	10	DR	DR	NNP
cord-267897-w4pbq2lb	248	11	,	,	,
cord-267897-w4pbq2lb	248	12	as	as	RB
cord-267897-w4pbq2lb	248	13	well	well	RB
cord-267897-w4pbq2lb	248	14	as	as	IN
cord-267897-w4pbq2lb	248	15	CD86	CD86	NNP
cord-267897-w4pbq2lb	248	16	and	and	CC
cord-267897-w4pbq2lb	248	17	CD71	CD71	NNP
cord-267897-w4pbq2lb	248	18	.	.	.
cord-267897-w4pbq2lb	249	1	Almost	almost	RB
cord-267897-w4pbq2lb	249	2	80	80	CD
cord-267897-w4pbq2lb	249	3	%	%	NN
cord-267897-w4pbq2lb	249	4	of	of	IN
cord-267897-w4pbq2lb	249	5	the	the	DT
cord-267897-w4pbq2lb	249	6	macrophages	macrophage	NNS
cord-267897-w4pbq2lb	249	7	obtained	obtain	VBN
cord-267897-w4pbq2lb	249	8	were	be	VBD
cord-267897-w4pbq2lb	249	9	positive	positive	JJ
cord-267897-w4pbq2lb	249	10	for	for	IN
cord-267897-w4pbq2lb	249	11	the	the	DT
cord-267897-w4pbq2lb	249	12	scavenger	scavenger	NN
cord-267897-w4pbq2lb	249	13	receptor	receptor	NN
cord-267897-w4pbq2lb	249	14	CD163	CD163	NNP
cord-267897-w4pbq2lb	249	15	.	.	.
cord-267897-w4pbq2lb	250	1	However	however	RB
cord-267897-w4pbq2lb	250	2	,	,	,
cord-267897-w4pbq2lb	250	3	incubation	incubation	NN
cord-267897-w4pbq2lb	250	4	with	with	IN
cord-267897-w4pbq2lb	250	5	aluminum	aluminum	NN
cord-267897-w4pbq2lb	250	6	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	250	7	downregulated	downregulate	VBD
cord-267897-w4pbq2lb	250	8	both	both	CC
cord-267897-w4pbq2lb	250	9	Fc	Fc	NNP
cord-267897-w4pbq2lb	250	10	g	g	NN
cord-267897-w4pbq2lb	250	11	R	r	NN
cord-267897-w4pbq2lb	250	12	and	and	CC
cord-267897-w4pbq2lb	250	13	CD163	CD163	NNP
cord-267897-w4pbq2lb	250	14	.	.	.
cord-267897-w4pbq2lb	251	1	Macrophages	macrophage	NNS
cord-267897-w4pbq2lb	251	2	,	,	,
cord-267897-w4pbq2lb	251	3	as	as	IN
cord-267897-w4pbq2lb	251	4	they	-PRON-	PRP
cord-267897-w4pbq2lb	251	5	expressed	express	VBD
cord-267897-w4pbq2lb	251	6	a	a	DT
cord-267897-w4pbq2lb	251	7	dendritic	dendritic	JJ
cord-267897-w4pbq2lb	251	8	cell	cell	NN
cord-267897-w4pbq2lb	251	9	(	(	-LRB-
cord-267897-w4pbq2lb	251	10	DC)elike	DC)elike	NNP
cord-267897-w4pbq2lb	251	11	phenotype	phenotype	NN
cord-267897-w4pbq2lb	251	12	after	after	IN
cord-267897-w4pbq2lb	251	13	incubation	incubation	NN
cord-267897-w4pbq2lb	251	14	with	with	IN
cord-267897-w4pbq2lb	251	15	aluminum	aluminum	NN
cord-267897-w4pbq2lb	251	16	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	252	1	(	(	-LRB-
cord-267897-w4pbq2lb	252	2	HLA	HLA	NNP
cord-267897-w4pbq2lb	252	3	-	-	HYPH
cord-267897-w4pbq2lb	252	4	DR	DR	NNP
cord-267897-w4pbq2lb	252	5	high	high	NN
cord-267897-w4pbq2lb	252	6	,	,	,
cord-267897-w4pbq2lb	252	7	CD86	CD86	NNP
cord-267897-w4pbq2lb	252	8	high	high	JJ
cord-267897-w4pbq2lb	252	9	,	,	,
cord-267897-w4pbq2lb	252	10	and	and	CC
cord-267897-w4pbq2lb	252	11	CD14	CD14	NNP
cord-267897-w4pbq2lb	252	12	À	À	NNP
cord-267897-w4pbq2lb	252	13	)	)	-RRB-
cord-267897-w4pbq2lb	252	14	,	,	,
cord-267897-w4pbq2lb	252	15	were	be	VBD
cord-267897-w4pbq2lb	252	16	further	further	RB
cord-267897-w4pbq2lb	252	17	investigated	investigate	VBN
cord-267897-w4pbq2lb	252	18	for	for	IN
cord-267897-w4pbq2lb	252	19	the	the	DT
cord-267897-w4pbq2lb	252	20	expression	expression	NN
cord-267897-w4pbq2lb	252	21	of	of	IN
cord-267897-w4pbq2lb	252	22	DCe	DCe	NNP
cord-267897-w4pbq2lb	252	23	specific	specific	JJ
cord-267897-w4pbq2lb	252	24	markers	marker	NNS
cord-267897-w4pbq2lb	252	25	.	.	.
cord-267897-w4pbq2lb	253	1	The	the	DT
cord-267897-w4pbq2lb	253	2	expression	expression	NN
cord-267897-w4pbq2lb	253	3	of	of	IN
cord-267897-w4pbq2lb	253	4	CD83	CD83	NNP
cord-267897-w4pbq2lb	253	5	increased	increase	VBD
cord-267897-w4pbq2lb	253	6	after	after	IN
cord-267897-w4pbq2lb	253	7	15	15	CD
cord-267897-w4pbq2lb	253	8	h	h	NN
cord-267897-w4pbq2lb	253	9	of	of	IN
cord-267897-w4pbq2lb	253	10	incubation	incubation	NN
cord-267897-w4pbq2lb	253	11	with	with	IN
cord-267897-w4pbq2lb	253	12	aluminum	aluminum	NN
cord-267897-w4pbq2lb	253	13	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	253	14	,	,	,
cord-267897-w4pbq2lb	253	15	compared	compare	VBN
cord-267897-w4pbq2lb	253	16	with	with	IN
cord-267897-w4pbq2lb	253	17	noneAl(OH	noneal(oh	CD
cord-267897-w4pbq2lb	253	18	)	)	-RRB-
cord-267897-w4pbq2lb	253	19	3	3	CD
cord-267897-w4pbq2lb	253	20	-stimulated	-stimulated	JJ
cord-267897-w4pbq2lb	253	21	cells	cell	NNS
cord-267897-w4pbq2lb	253	22	.	.	.
cord-267897-w4pbq2lb	254	1	It	-PRON-	PRP
cord-267897-w4pbq2lb	254	2	turned	turn	VBD
cord-267897-w4pbq2lb	254	3	out	out	RP
cord-267897-w4pbq2lb	254	4	that	that	IN
cord-267897-w4pbq2lb	254	5	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	254	6	-	-	HYPH
cord-267897-w4pbq2lb	254	7	stimulated	stimulate	VBN
cord-267897-w4pbq2lb	254	8	macrophages	macrophage	NNS
cord-267897-w4pbq2lb	254	9	were	be	VBD
cord-267897-w4pbq2lb	254	10	also	also	RB
cord-267897-w4pbq2lb	254	11	superior	superior	JJ
cord-267897-w4pbq2lb	254	12	in	in	IN
cord-267897-w4pbq2lb	254	13	antigen	antigen	NN
cord-267897-w4pbq2lb	254	14	presentation	presentation	NN
cord-267897-w4pbq2lb	254	15	.	.	.
cord-267897-w4pbq2lb	255	1	Based	base	VBN
cord-267897-w4pbq2lb	255	2	on	on	IN
cord-267897-w4pbq2lb	255	3	these	these	DT
cord-267897-w4pbq2lb	255	4	findings	finding	NNS
cord-267897-w4pbq2lb	255	5	,	,	,
cord-267897-w4pbq2lb	255	6	Rimaniol	Rimaniol	NNP
cord-267897-w4pbq2lb	255	7	et	et	NNP
cord-267897-w4pbq2lb	255	8	al	al	NNP
cord-267897-w4pbq2lb	255	9	.	.	NNP
cord-267897-w4pbq2lb	255	10	concluded	conclude	VBD
cord-267897-w4pbq2lb	255	11	that	that	IN
cord-267897-w4pbq2lb	255	12	stimulation	stimulation	NN
cord-267897-w4pbq2lb	255	13	with	with	IN
cord-267897-w4pbq2lb	255	14	aluminum	aluminum	NN
cord-267897-w4pbq2lb	255	15	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	255	16	led	lead	VBD
cord-267897-w4pbq2lb	255	17	to	to	IN
cord-267897-w4pbq2lb	255	18	differentiation	differentiation	NN
cord-267897-w4pbq2lb	255	19	of	of	IN
cord-267897-w4pbq2lb	255	20	the	the	DT
cord-267897-w4pbq2lb	255	21	macrophages	macrophage	NNS
cord-267897-w4pbq2lb	255	22	into	into	IN
cord-267897-w4pbq2lb	255	23	a	a	DT
cord-267897-w4pbq2lb	255	24	form	form	NN
cord-267897-w4pbq2lb	255	25	sharing	share	VBG
cord-267897-w4pbq2lb	255	26	some	some	DT
cord-267897-w4pbq2lb	255	27	features	feature	NNS
cord-267897-w4pbq2lb	255	28	with	with	IN
cord-267897-w4pbq2lb	255	29	,	,	,
cord-267897-w4pbq2lb	255	30	but	but	CC
cord-267897-w4pbq2lb	255	31	still	still	RB
cord-267897-w4pbq2lb	255	32	distinctly	distinctly	RB
cord-267897-w4pbq2lb	255	33	different	different	JJ
cord-267897-w4pbq2lb	255	34	from	from	IN
cord-267897-w4pbq2lb	255	35	,	,	,
cord-267897-w4pbq2lb	255	36	DCs	DCs	NNP
cord-267897-w4pbq2lb	255	37	.	.	.
cord-267897-w4pbq2lb	256	1	No	no	DT
cord-267897-w4pbq2lb	256	2	similar	similar	JJ
cord-267897-w4pbq2lb	256	3	data	datum	NNS
cord-267897-w4pbq2lb	256	4	are	be	VBP
cord-267897-w4pbq2lb	256	5	at	at	IN
cord-267897-w4pbq2lb	256	6	the	the	DT
cord-267897-w4pbq2lb	256	7	moment	moment	NN
cord-267897-w4pbq2lb	256	8	available	available	JJ
cord-267897-w4pbq2lb	256	9	for	for	IN
cord-267897-w4pbq2lb	256	10	the	the	DT
cord-267897-w4pbq2lb	256	11	calcium	calcium	NN
cord-267897-w4pbq2lb	256	12	phosphate	phosphate	NN
cord-267897-w4pbq2lb	256	13	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	256	14	.	.	.
cord-267897-w4pbq2lb	257	1	In	in	IN
cord-267897-w4pbq2lb	257	2	2002	2002	CD
cord-267897-w4pbq2lb	257	3	,	,	,
cord-267897-w4pbq2lb	257	4	a	a	DT
cord-267897-w4pbq2lb	257	5	group	group	NN
cord-267897-w4pbq2lb	257	6	at	at	IN
cord-267897-w4pbq2lb	257	7	University	University	NNP
cord-267897-w4pbq2lb	257	8	of	of	IN
cord-267897-w4pbq2lb	257	9	Lausanne	Lausanne	NNP
cord-267897-w4pbq2lb	257	10	,	,	,
cord-267897-w4pbq2lb	257	11	headed	head	VBN
cord-267897-w4pbq2lb	257	12	by	by	IN
cord-267897-w4pbq2lb	257	13	J€	J€	NNP
cord-267897-w4pbq2lb	257	14	urg	urg	NNP
cord-267897-w4pbq2lb	257	15	Tschopp	Tschopp	NNP
cord-267897-w4pbq2lb	257	16	,	,	,
cord-267897-w4pbq2lb	257	17	defined	define	VBD
cord-267897-w4pbq2lb	257	18	the	the	DT
cord-267897-w4pbq2lb	257	19	inflammasome	inflammasome	NN
cord-267897-w4pbq2lb	257	20	as	as	IN
cord-267897-w4pbq2lb	257	21	"	"	``
cord-267897-w4pbq2lb	257	22	a	a	DT
cord-267897-w4pbq2lb	257	23	molecular	molecular	JJ
cord-267897-w4pbq2lb	257	24	platform	platform	NN
cord-267897-w4pbq2lb	257	25	triggering	trigger	VBG
cord-267897-w4pbq2lb	257	26	activation	activation	NN
cord-267897-w4pbq2lb	257	27	of	of	IN
cord-267897-w4pbq2lb	257	28	inflammatory	inflammatory	JJ
cord-267897-w4pbq2lb	257	29	caspases	caspase	NNS
cord-267897-w4pbq2lb	257	30	and	and	CC
cord-267897-w4pbq2lb	257	31	processing	processing	NN
cord-267897-w4pbq2lb	257	32	of	of	IN
cord-267897-w4pbq2lb	257	33	pro	pro	JJ
cord-267897-w4pbq2lb	257	34	-	-	JJ
cord-267897-w4pbq2lb	257	35	IL	il	NN
cord-267897-w4pbq2lb	257	36	-	-	HYPH
cord-267897-w4pbq2lb	257	37	b	b	NN
cord-267897-w4pbq2lb	257	38	.	.	.
cord-267897-w4pbq2lb	258	1	"	"	``
cord-267897-w4pbq2lb	258	2	85	85	CD
cord-267897-w4pbq2lb	259	1	This	this	DT
cord-267897-w4pbq2lb	259	2	initiated	initiate	VBD
cord-267897-w4pbq2lb	259	3	a	a	DT
cord-267897-w4pbq2lb	259	4	new	new	JJ
cord-267897-w4pbq2lb	259	5	line	line	NN
cord-267897-w4pbq2lb	259	6	of	of	IN
cord-267897-w4pbq2lb	259	7	research	research	NN
cord-267897-w4pbq2lb	259	8	leading	lead	VBG
cord-267897-w4pbq2lb	259	9	to	to	IN
cord-267897-w4pbq2lb	259	10	a	a	DT
cord-267897-w4pbq2lb	259	11	possible	possible	JJ
cord-267897-w4pbq2lb	259	12	explanation	explanation	NN
cord-267897-w4pbq2lb	259	13	for	for	IN
cord-267897-w4pbq2lb	259	14	the	the	DT
cord-267897-w4pbq2lb	259	15	mechanisms	mechanism	NNS
cord-267897-w4pbq2lb	259	16	of	of	IN
cord-267897-w4pbq2lb	259	17	action	action	NN
cord-267897-w4pbq2lb	259	18	of	of	IN
cord-267897-w4pbq2lb	259	19	aluminum	aluminum	NN
cord-267897-w4pbq2lb	259	20	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	259	21	in	in	IN
cord-267897-w4pbq2lb	259	22	the	the	DT
cord-267897-w4pbq2lb	259	23	early	early	JJ
cord-267897-w4pbq2lb	259	24	phases	phase	NNS
cord-267897-w4pbq2lb	259	25	of	of	IN
cord-267897-w4pbq2lb	259	26	the	the	DT
cord-267897-w4pbq2lb	259	27	immune	immune	JJ
cord-267897-w4pbq2lb	259	28	response	response	NN
cord-267897-w4pbq2lb	259	29	with	with	IN
cord-267897-w4pbq2lb	259	30	the	the	DT
cord-267897-w4pbq2lb	259	31	stimulation	stimulation	NN
cord-267897-w4pbq2lb	259	32	and	and	CC
cord-267897-w4pbq2lb	259	33	excretion	excretion	NN
cord-267897-w4pbq2lb	259	34	of	of	IN
cord-267897-w4pbq2lb	259	35	proinflammatory	proinflammatory	JJ
cord-267897-w4pbq2lb	259	36	cytokines	cytokine	NNS
cord-267897-w4pbq2lb	259	37	.	.	.
cord-267897-w4pbq2lb	260	1	According	accord	VBG
cord-267897-w4pbq2lb	260	2	to	to	IN
cord-267897-w4pbq2lb	260	3	this	this	DT
cord-267897-w4pbq2lb	260	4	approach	approach	NN
cord-267897-w4pbq2lb	260	5	uptake	uptake	NN
cord-267897-w4pbq2lb	260	6	of	of	IN
cord-267897-w4pbq2lb	260	7	Al	Al	NNP
cord-267897-w4pbq2lb	260	8	-	-	HYPH
cord-267897-w4pbq2lb	260	9	adjuvanted	adjuvante	VBN
cord-267897-w4pbq2lb	260	10	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	260	11	by	by	IN
cord-267897-w4pbq2lb	260	12	DCs	DCs	NNP
cord-267897-w4pbq2lb	260	13	is	be	VBZ
cord-267897-w4pbq2lb	260	14	accompanied	accompany	VBN
cord-267897-w4pbq2lb	260	15	by	by	IN
cord-267897-w4pbq2lb	260	16	K	K	NNP
cord-267897-w4pbq2lb	260	17	þ	þ	NNP
cord-267897-w4pbq2lb	260	18	efflux	efflux	NN
cord-267897-w4pbq2lb	260	19	and	and	CC
cord-267897-w4pbq2lb	260	20	three	three	CD
cord-267897-w4pbq2lb	260	21	intracellular	intracellular	JJ
cord-267897-w4pbq2lb	260	22	proteins	protein	NNS
cord-267897-w4pbq2lb	260	23	,	,	,
cord-267897-w4pbq2lb	260	24	known	know	VBN
cord-267897-w4pbq2lb	260	25	as	as	IN
cord-267897-w4pbq2lb	260	26	NALP3	NALP3	NNP
cord-267897-w4pbq2lb	260	27	(	(	-LRB-
cord-267897-w4pbq2lb	260	28	also	also	RB
cord-267897-w4pbq2lb	260	29	known	know	VBN
cord-267897-w4pbq2lb	260	30	as	as	IN
cord-267897-w4pbq2lb	260	31	cryopyrin	cryopyrin	NNP
cord-267897-w4pbq2lb	260	32	)	)	-RRB-
cord-267897-w4pbq2lb	260	33	,	,	,
cord-267897-w4pbq2lb	260	34	CARDINAL	CARDINAL	NNP
cord-267897-w4pbq2lb	260	35	,	,	,
cord-267897-w4pbq2lb	260	36	and	and	CC
cord-267897-w4pbq2lb	260	37	ASC	ASC	NNP
cord-267897-w4pbq2lb	260	38	,	,	,
cord-267897-w4pbq2lb	260	39	then	then	RB
cord-267897-w4pbq2lb	260	40	join	join	VB
cord-267897-w4pbq2lb	260	41	to	to	TO
cord-267897-w4pbq2lb	260	42	form	form	VB
cord-267897-w4pbq2lb	260	43	the	the	DT
cord-267897-w4pbq2lb	260	44	so	so	RB
cord-267897-w4pbq2lb	260	45	-	-	HYPH
cord-267897-w4pbq2lb	260	46	called	call	VBN
cord-267897-w4pbq2lb	260	47	NALP3	NALP3	``
cord-267897-w4pbq2lb	260	48	inflammasome	inflammasome	NNP
cord-267897-w4pbq2lb	260	49	(	(	-LRB-
cord-267897-w4pbq2lb	260	50	Fig	Fig	NNP
cord-267897-w4pbq2lb	260	51	.	.	.
cord-267897-w4pbq2lb	260	52	18.5	18.5	CD
cord-267897-w4pbq2lb	260	53	)	)	-RRB-
cord-267897-w4pbq2lb	260	54	,	,	,
cord-267897-w4pbq2lb	260	55	possibly	possibly	RB
cord-267897-w4pbq2lb	260	56	through	through	IN
cord-267897-w4pbq2lb	260	57	phagosomal	phagosomal	NN
cord-267897-w4pbq2lb	260	58	destabilization	destabilization	NN
cord-267897-w4pbq2lb	260	59	.	.	.
cord-267897-w4pbq2lb	261	1	86	86	CD
cord-267897-w4pbq2lb	262	1	Upon	upon	IN
cord-267897-w4pbq2lb	262	2	assembly	assembly	NN
cord-267897-w4pbq2lb	262	3	the	the	DT
cord-267897-w4pbq2lb	262	4	NALP3	NALP3	NNP
cord-267897-w4pbq2lb	262	5	inflammasome	inflammasome	NNP
cord-267897-w4pbq2lb	262	6	induces	induce	VBZ
cord-267897-w4pbq2lb	262	7	cleavage	cleavage	NN
cord-267897-w4pbq2lb	262	8	of	of	IN
cord-267897-w4pbq2lb	262	9	the	the	DT
cord-267897-w4pbq2lb	262	10	45-kDa	45-kda	CD
cord-267897-w4pbq2lb	263	1	procaspase-1	procaspase-1	XX
cord-267897-w4pbq2lb	264	1	turning	turn	VBG
cord-267897-w4pbq2lb	264	2	it	-PRON-	PRP
cord-267897-w4pbq2lb	264	3	into	into	IN
cord-267897-w4pbq2lb	264	4	the	the	DT
cord-267897-w4pbq2lb	264	5	active	active	JJ
cord-267897-w4pbq2lb	264	6	caspase-1	caspase-1	NNP
cord-267897-w4pbq2lb	264	7	enzyme	enzyme	NN
cord-267897-w4pbq2lb	264	8	,	,	,
cord-267897-w4pbq2lb	264	9	which	which	WDT
cord-267897-w4pbq2lb	264	10	is	be	VBZ
cord-267897-w4pbq2lb	264	11	able	able	JJ
cord-267897-w4pbq2lb	264	12	to	to	TO
cord-267897-w4pbq2lb	264	13	cleave	cleave	VB
cord-267897-w4pbq2lb	264	14	pro	pro	JJ
cord-267897-w4pbq2lb	264	15	-	-	JJ
cord-267897-w4pbq2lb	264	16	IL-1b	il-1b	JJ
cord-267897-w4pbq2lb	264	17	and	and	CC
cord-267897-w4pbq2lb	264	18	pro	pro	JJ
cord-267897-w4pbq2lb	264	19	-	-	JJ
cord-267897-w4pbq2lb	264	20	IL-18	IL-18	NNP
cord-267897-w4pbq2lb	264	21	into	into	IN
cord-267897-w4pbq2lb	264	22	their	-PRON-	PRP$
cord-267897-w4pbq2lb	264	23	active	active	JJ
cord-267897-w4pbq2lb	264	24	counterparts	counterpart	NNS
cord-267897-w4pbq2lb	264	25	:	:	:
cord-267897-w4pbq2lb	265	1	IL-1b	IL-1b	NNP
cord-267897-w4pbq2lb	265	2	and	and	CC
cord-267897-w4pbq2lb	265	3	IL-18	IL-18	NNP
cord-267897-w4pbq2lb	265	4	.	.	.
cord-267897-w4pbq2lb	266	1	These	these	DT
cord-267897-w4pbq2lb	266	2	can	can	MD
cord-267897-w4pbq2lb	266	3	then	then	RB
cord-267897-w4pbq2lb	266	4	leave	leave	VB
cord-267897-w4pbq2lb	266	5	the	the	DT
cord-267897-w4pbq2lb	266	6	DC	DC	NNP
cord-267897-w4pbq2lb	266	7	as	as	IN
cord-267897-w4pbq2lb	266	8	active	active	JJ
cord-267897-w4pbq2lb	266	9	,	,	,
cord-267897-w4pbq2lb	266	10	proinflammatory	proinflammatory	JJ
cord-267897-w4pbq2lb	266	11	cytokines	cytokine	NNS
cord-267897-w4pbq2lb	266	12	.	.	.
cord-267897-w4pbq2lb	267	1	87e90	87e90	CD
cord-267897-w4pbq2lb	268	1	In	in	IN
cord-267897-w4pbq2lb	268	2	NALP3	NALP3	NNP
cord-267897-w4pbq2lb	268	3	À	à	NN
cord-267897-w4pbq2lb	268	4	/	/	SYM
cord-267897-w4pbq2lb	268	5	À	à	NN
cord-267897-w4pbq2lb	268	6	mice	mouse	NNS
cord-267897-w4pbq2lb	268	7	no	no	DT
cord-267897-w4pbq2lb	268	8	significant	significant	JJ
cord-267897-w4pbq2lb	268	9	increase	increase	NN
cord-267897-w4pbq2lb	268	10	in	in	IN
cord-267897-w4pbq2lb	268	11	IL-1b	IL-1b	NNS
cord-267897-w4pbq2lb	268	12	was	be	VBD
cord-267897-w4pbq2lb	268	13	seen	see	VBN
cord-267897-w4pbq2lb	268	14	when	when	WRB
cord-267897-w4pbq2lb	268	15	compared	compare	VBN
cord-267897-w4pbq2lb	268	16	with	with	IN
cord-267897-w4pbq2lb	268	17	the	the	DT
cord-267897-w4pbq2lb	268	18	level	level	NN
cord-267897-w4pbq2lb	268	19	seen	see	VBN
cord-267897-w4pbq2lb	268	20	in	in	IN
cord-267897-w4pbq2lb	268	21	mice	mouse	NNS
cord-267897-w4pbq2lb	268	22	receiving	receive	VBG
cord-267897-w4pbq2lb	268	23	saline	saline	NN
cord-267897-w4pbq2lb	268	24	or	or	CC
cord-267897-w4pbq2lb	268	25	antigen	antigen	NN
cord-267897-w4pbq2lb	268	26	alone	alone	RB
cord-267897-w4pbq2lb	268	27	,	,	,
cord-267897-w4pbq2lb	268	28	87	87	CD
cord-267897-w4pbq2lb	268	29	and	and	CC
cord-267897-w4pbq2lb	268	30	since	since	IN
cord-267897-w4pbq2lb	268	31	the	the	DT
cord-267897-w4pbq2lb	268	32	process	process	NN
cord-267897-w4pbq2lb	268	33	could	could	MD
cord-267897-w4pbq2lb	268	34	take	take	VB
cord-267897-w4pbq2lb	268	35	place	place	NN
cord-267897-w4pbq2lb	268	36	in	in	IN
cord-267897-w4pbq2lb	268	37	MyD88-deficient	MyD88-deficient	NNP
cord-267897-w4pbq2lb	268	38	mice	mouse	NNS
cord-267897-w4pbq2lb	268	39	,	,	,
cord-267897-w4pbq2lb	268	40	88	88	CD
cord-267897-w4pbq2lb	268	41	it	-PRON-	PRP
cord-267897-w4pbq2lb	268	42	was	be	VBD
cord-267897-w4pbq2lb	268	43	not	not	RB
cord-267897-w4pbq2lb	268	44	considered	consider	VBN
cord-267897-w4pbq2lb	268	45	MyD88	MyD88	NNS
cord-267897-w4pbq2lb	268	46	dependent	dependent	JJ
cord-267897-w4pbq2lb	268	47	.	.	.
cord-267897-w4pbq2lb	269	1	The	the	DT
cord-267897-w4pbq2lb	269	2	synthesis	synthesis	NN
cord-267897-w4pbq2lb	269	3	of	of	IN
cord-267897-w4pbq2lb	269	4	pro	pro	JJ
cord-267897-w4pbq2lb	269	5	-	-	JJ
cord-267897-w4pbq2lb	269	6	IL-1b	il-1b	JJ
cord-267897-w4pbq2lb	269	7	and	and	CC
cord-267897-w4pbq2lb	269	8	pro	pro	JJ
cord-267897-w4pbq2lb	269	9	-	-	:
cord-267897-w4pbq2lb	269	10	IL-18	IL-18	NNP
cord-267897-w4pbq2lb	269	11	is	be	VBZ
cord-267897-w4pbq2lb	269	12	affected	affect	VBN
cord-267897-w4pbq2lb	269	13	by	by	IN
cord-267897-w4pbq2lb	269	14	TLR	TLR	NNP
cord-267897-w4pbq2lb	269	15	agonists	agonist	NNS
cord-267897-w4pbq2lb	269	16	reacting	react	VBG
cord-267897-w4pbq2lb	269	17	with	with	IN
cord-267897-w4pbq2lb	269	18	TLRs	tlr	NNS
cord-267897-w4pbq2lb	269	19	on	on	IN
cord-267897-w4pbq2lb	269	20	the	the	DT
cord-267897-w4pbq2lb	269	21	surface	surface	NN
cord-267897-w4pbq2lb	269	22	of	of	IN
cord-267897-w4pbq2lb	269	23	the	the	DT
cord-267897-w4pbq2lb	269	24	DC	DC	NNP
cord-267897-w4pbq2lb	269	25	.	.	.
cord-267897-w4pbq2lb	270	1	Upon	upon	IN
cord-267897-w4pbq2lb	270	2	reaction	reaction	NN
cord-267897-w4pbq2lb	270	3	with	with	IN
cord-267897-w4pbq2lb	270	4	surface	surface	NN
cord-267897-w4pbq2lb	270	5	-	-	HYPH
cord-267897-w4pbq2lb	270	6	associated	associate	VBN
cord-267897-w4pbq2lb	270	7	TLRs	TLRs	NNP
cord-267897-w4pbq2lb	270	8	,	,	,
cord-267897-w4pbq2lb	270	9	it	-PRON-	PRP
cord-267897-w4pbq2lb	270	10	is	be	VBZ
cord-267897-w4pbq2lb	270	11	believed	believe	VBN
cord-267897-w4pbq2lb	270	12	that	that	IN
cord-267897-w4pbq2lb	270	13	the	the	DT
cord-267897-w4pbq2lb	270	14	nuclear	nuclear	JJ
cord-267897-w4pbq2lb	270	15	factor	factor	NN
cord-267897-w4pbq2lb	270	16	(	(	-LRB-
cord-267897-w4pbq2lb	270	17	NF)-kB	NF)-kB	NNP
cord-267897-w4pbq2lb	270	18	pathway	pathway	NN
cord-267897-w4pbq2lb	270	19	is	be	VBZ
cord-267897-w4pbq2lb	270	20	activated	activate	VBN
cord-267897-w4pbq2lb	270	21	and	and	CC
cord-267897-w4pbq2lb	270	22	the	the	DT
cord-267897-w4pbq2lb	270	23	genes	gene	NNS
cord-267897-w4pbq2lb	270	24	for	for	IN
cord-267897-w4pbq2lb	270	25	pro	pro	JJ
cord-267897-w4pbq2lb	270	26	-	-	JJ
cord-267897-w4pbq2lb	270	27	IL-1b	il-1b	JJ
cord-267897-w4pbq2lb	270	28	and	and	CC
cord-267897-w4pbq2lb	270	29	pro	pro	JJ
cord-267897-w4pbq2lb	270	30	-	-	:
cord-267897-w4pbq2lb	270	31	IL-18	IL-18	NNP
cord-267897-w4pbq2lb	270	32	are	be	VBP
cord-267897-w4pbq2lb	270	33	transcribed	transcribe	VBN
cord-267897-w4pbq2lb	270	34	in	in	IN
cord-267897-w4pbq2lb	270	35	the	the	DT
cord-267897-w4pbq2lb	270	36	nucleus	nucleus	NN
cord-267897-w4pbq2lb	270	37	of	of	IN
cord-267897-w4pbq2lb	270	38	the	the	DT
cord-267897-w4pbq2lb	270	39	DC	DC	NNP
cord-267897-w4pbq2lb	270	40	.	.	.
cord-267897-w4pbq2lb	271	1	Additional	additional	JJ
cord-267897-w4pbq2lb	271	2	mechanisms	mechanism	NNS
cord-267897-w4pbq2lb	271	3	may	may	MD
cord-267897-w4pbq2lb	271	4	hypothetically	hypothetically	RB
cord-267897-w4pbq2lb	271	5	contribute	contribute	VB
cord-267897-w4pbq2lb	271	6	to	to	IN
cord-267897-w4pbq2lb	271	7	the	the	DT
cord-267897-w4pbq2lb	271	8	availability	availability	NN
cord-267897-w4pbq2lb	271	9	of	of	IN
cord-267897-w4pbq2lb	271	10	pro	pro	JJ
cord-267897-w4pbq2lb	271	11	-	-	JJ
cord-267897-w4pbq2lb	271	12	IL-1b	il-1b	JJ
cord-267897-w4pbq2lb	271	13	and	and	CC
cord-267897-w4pbq2lb	271	14	pro	pro	JJ
cord-267897-w4pbq2lb	271	15	-	-	JJ
cord-267897-w4pbq2lb	271	16	IL-18	IL-18	NNP
cord-267897-w4pbq2lb	271	17	in	in	IN
cord-267897-w4pbq2lb	271	18	vivo	vivo	NN
cord-267897-w4pbq2lb	271	19	.	.	.
cord-267897-w4pbq2lb	272	1	For	for	IN
cord-267897-w4pbq2lb	272	2	example	example	NN
cord-267897-w4pbq2lb	272	3	,	,	,
cord-267897-w4pbq2lb	272	4	the	the	DT
cord-267897-w4pbq2lb	272	5	antigen	antigen	NN
cord-267897-w4pbq2lb	272	6	itself	-PRON-	PRP
cord-267897-w4pbq2lb	272	7	may	may	MD
cord-267897-w4pbq2lb	272	8	contain	contain	VB
cord-267897-w4pbq2lb	272	9	PAMPs	pamp	NNS
cord-267897-w4pbq2lb	272	10	and	and	CC
cord-267897-w4pbq2lb	272	11	thereby	thereby	RB
cord-267897-w4pbq2lb	272	12	fulfill	fulfill	VB
cord-267897-w4pbq2lb	272	13	the	the	DT
cord-267897-w4pbq2lb	272	14	function	function	NN
cord-267897-w4pbq2lb	272	15	as	as	IN
cord-267897-w4pbq2lb	272	16	TLR	TLR	NNP
cord-267897-w4pbq2lb	272	17	agonists	agonist	NNS
cord-267897-w4pbq2lb	272	18	.	.	.
cord-267897-w4pbq2lb	273	1	This	this	DT
cord-267897-w4pbq2lb	273	2	draws	draw	VBZ
cord-267897-w4pbq2lb	273	3	a	a	DT
cord-267897-w4pbq2lb	273	4	line	line	NN
cord-267897-w4pbq2lb	273	5	back	back	RB
cord-267897-w4pbq2lb	273	6	to	to	IN
cord-267897-w4pbq2lb	273	7	the	the	DT
cord-267897-w4pbq2lb	273	8	original	original	JJ
cord-267897-w4pbq2lb	273	9	sustained	sustain	VBN
cord-267897-w4pbq2lb	273	10	-	-	HYPH
cord-267897-w4pbq2lb	273	11	release	release	NN
cord-267897-w4pbq2lb	273	12	theory	theory	NN
cord-267897-w4pbq2lb	273	13	,	,	,
cord-267897-w4pbq2lb	273	14	as	as	IN
cord-267897-w4pbq2lb	273	15	antigen	antigen	NN
cord-267897-w4pbq2lb	273	16	released	release	VBN
cord-267897-w4pbq2lb	273	17	from	from	IN
cord-267897-w4pbq2lb	273	18	an	an	DT
cord-267897-w4pbq2lb	273	19	Al	Al	NNP
cord-267897-w4pbq2lb	273	20	-	-	HYPH
cord-267897-w4pbq2lb	273	21	adjuvanted	adjuvante	VBN
cord-267897-w4pbq2lb	273	22	depot	depot	NN
cord-267897-w4pbq2lb	273	23	,	,	,
cord-267897-w4pbq2lb	273	24	as	as	IN
cord-267897-w4pbq2lb	273	25	a	a	DT
cord-267897-w4pbq2lb	273	26	consequence	consequence	NN
cord-267897-w4pbq2lb	273	27	of	of	IN
cord-267897-w4pbq2lb	273	28	interaction	interaction	NN
cord-267897-w4pbq2lb	273	29	with	with	IN
cord-267897-w4pbq2lb	273	30	interstitial	interstitial	JJ
cord-267897-w4pbq2lb	273	31	fluid	fluid	NN
cord-267897-w4pbq2lb	273	32	,	,	,
cord-267897-w4pbq2lb	273	33	may	may	MD
cord-267897-w4pbq2lb	273	34	expose	expose	VB
cord-267897-w4pbq2lb	273	35	antigen	antigen	NN
cord-267897-w4pbq2lb	273	36	-	-	HYPH
cord-267897-w4pbq2lb	273	37	associated	associate	VBN
cord-267897-w4pbq2lb	273	38	PAMPs	pamp	NNS
cord-267897-w4pbq2lb	273	39	to	to	TO
cord-267897-w4pbq2lb	273	40	surface	surface	VB
cord-267897-w4pbq2lb	273	41	TLRs	tlr	NNS
cord-267897-w4pbq2lb	273	42	on	on	IN
cord-267897-w4pbq2lb	273	43	nearby	nearby	JJ
cord-267897-w4pbq2lb	273	44	DCs	DCs	NNP
cord-267897-w4pbq2lb	273	45	attracted	attract	VBD
cord-267897-w4pbq2lb	273	46	to	to	IN
cord-267897-w4pbq2lb	273	47	the	the	DT
cord-267897-w4pbq2lb	273	48	inoculum	inoculum	NN
cord-267897-w4pbq2lb	273	49	at	at	IN
cord-267897-w4pbq2lb	273	50	the	the	DT
cord-267897-w4pbq2lb	273	51	injection	injection	NN
cord-267897-w4pbq2lb	273	52	site	site	NN
cord-267897-w4pbq2lb	273	53	.	.	.
cord-267897-w4pbq2lb	274	1	Apparently	apparently	RB
cord-267897-w4pbq2lb	274	2	,	,	,
cord-267897-w4pbq2lb	274	3	the	the	DT
cord-267897-w4pbq2lb	274	4	activation	activation	NN
cord-267897-w4pbq2lb	274	5	of	of	IN
cord-267897-w4pbq2lb	274	6	the	the	DT
cord-267897-w4pbq2lb	274	7	NALP3	NALP3	NNP
cord-267897-w4pbq2lb	274	8	inflammasome	inflammasome	NNP
cord-267897-w4pbq2lb	274	9	in	in	IN
cord-267897-w4pbq2lb	274	10	DC	DC	NNP
cord-267897-w4pbq2lb	274	11	's	's	POS
cord-267897-w4pbq2lb	274	12	is	be	VBZ
cord-267897-w4pbq2lb	274	13	not	not	RB
cord-267897-w4pbq2lb	274	14	limited	limited	JJ
cord-267897-w4pbq2lb	274	15	to	to	IN
cord-267897-w4pbq2lb	274	16	being	be	VBG
cord-267897-w4pbq2lb	274	17	a	a	DT
cord-267897-w4pbq2lb	274	18	consequence	consequence	NN
cord-267897-w4pbq2lb	274	19	of	of	IN
cord-267897-w4pbq2lb	274	20	uptake	uptake	NN
cord-267897-w4pbq2lb	274	21	of	of	IN
cord-267897-w4pbq2lb	274	22	aluminum	aluminum	NN
cord-267897-w4pbq2lb	274	23	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	274	24	.	.	.
cord-267897-w4pbq2lb	275	1	The	the	DT
cord-267897-w4pbq2lb	275	2	NALP3	NALP3	NNP
cord-267897-w4pbq2lb	275	3	inflammasome	inflammasome	NNP
cord-267897-w4pbq2lb	275	4	can	can	MD
cord-267897-w4pbq2lb	275	5	also	also	RB
cord-267897-w4pbq2lb	275	6	be	be	VB
cord-267897-w4pbq2lb	275	7	activated	activate	VBN
cord-267897-w4pbq2lb	275	8	by	by	IN
cord-267897-w4pbq2lb	275	9	uptake	uptake	NN
cord-267897-w4pbq2lb	275	10	of	of	IN
cord-267897-w4pbq2lb	275	11	,	,	,
cord-267897-w4pbq2lb	275	12	e.g.	e.g.	RB
cord-267897-w4pbq2lb	275	13	,	,	,
cord-267897-w4pbq2lb	275	14	uric	uric	NN
cord-267897-w4pbq2lb	275	15	acid	acid	NN
cord-267897-w4pbq2lb	275	16	crystals	crystal	NNS
cord-267897-w4pbq2lb	275	17	.	.	.
cord-267897-w4pbq2lb	276	1	Uric	uric	JJ
cord-267897-w4pbq2lb	276	2	acid	acid	NN
cord-267897-w4pbq2lb	276	3	crystals	crystal	NNS
cord-267897-w4pbq2lb	276	4	are	be	VBP
cord-267897-w4pbq2lb	277	1	very	very	RB
cord-267897-w4pbq2lb	277	2	powerful	powerful	JJ
cord-267897-w4pbq2lb	277	3	danger	danger	NN
cord-267897-w4pbq2lb	277	4	signals	signal	NNS
cord-267897-w4pbq2lb	277	5	91	91	CD
cord-267897-w4pbq2lb	277	6	released	release	VBD
cord-267897-w4pbq2lb	277	7	from	from	IN
cord-267897-w4pbq2lb	277	8	dying	die	VBG
cord-267897-w4pbq2lb	277	9	cells	cell	NNS
cord-267897-w4pbq2lb	277	10	as	as	IN
cord-267897-w4pbq2lb	277	11	breakdown	breakdown	NN
cord-267897-w4pbq2lb	277	12	products	product	NNS
cord-267897-w4pbq2lb	277	13	of	of	IN
cord-267897-w4pbq2lb	277	14	nucleic	nucleic	JJ
cord-267897-w4pbq2lb	277	15	acids	acid	NNS
cord-267897-w4pbq2lb	277	16	and	and	CC
cord-267897-w4pbq2lb	277	17	,	,	,
cord-267897-w4pbq2lb	277	18	in	in	IN
cord-267897-w4pbq2lb	277	19	what	what	WP
cord-267897-w4pbq2lb	277	20	appears	appear	VBZ
cord-267897-w4pbq2lb	277	21	to	to	TO
cord-267897-w4pbq2lb	277	22	be	be	VB
cord-267897-w4pbq2lb	277	23	a	a	DT
cord-267897-w4pbq2lb	277	24	combination	combination	NN
cord-267897-w4pbq2lb	277	25	of	of	IN
cord-267897-w4pbq2lb	277	26	the	the	DT
cord-267897-w4pbq2lb	277	27	two	two	CD
cord-267897-w4pbq2lb	277	28	views	view	NNS
cord-267897-w4pbq2lb	277	29	,	,	,
cord-267897-w4pbq2lb	277	30	it	-PRON-	PRP
cord-267897-w4pbq2lb	277	31	has	have	VBZ
cord-267897-w4pbq2lb	277	32	been	be	VBN
cord-267897-w4pbq2lb	277	33	suggested	suggest	VBN
cord-267897-w4pbq2lb	277	34	that	that	IN
cord-267897-w4pbq2lb	277	35	phagocytic	phagocytic	JJ
cord-267897-w4pbq2lb	277	36	cells	cell	NNS
cord-267897-w4pbq2lb	277	37	taking	take	VBG
cord-267897-w4pbq2lb	277	38	up	up	RP
cord-267897-w4pbq2lb	277	39	aluminum	aluminum	NN
cord-267897-w4pbq2lb	277	40	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	277	41	may	may	MD
cord-267897-w4pbq2lb	277	42	release	release	VB
cord-267897-w4pbq2lb	277	43	uric	uric	NN
cord-267897-w4pbq2lb	277	44	acid	acid	NN
cord-267897-w4pbq2lb	277	45	crystals	crystal	NNS
cord-267897-w4pbq2lb	277	46	as	as	IN
cord-267897-w4pbq2lb	277	47	danger	danger	NN
cord-267897-w4pbq2lb	277	48	signals	signal	NNS
cord-267897-w4pbq2lb	277	49	,	,	,
cord-267897-w4pbq2lb	277	50	stimulating	stimulate	VBG
cord-267897-w4pbq2lb	277	51	the	the	DT
cord-267897-w4pbq2lb	277	52	formation	formation	NN
cord-267897-w4pbq2lb	277	53	of	of	IN
cord-267897-w4pbq2lb	277	54	the	the	DT
cord-267897-w4pbq2lb	277	55	NALP3	NALP3	NNP
cord-267897-w4pbq2lb	277	56	inflammasome	inflammasome	NNP
cord-267897-w4pbq2lb	277	57	in	in	IN
cord-267897-w4pbq2lb	277	58	DCs	DCs	NNP
cord-267897-w4pbq2lb	277	59	.	.	.
cord-267897-w4pbq2lb	278	1	92	92	CD
cord-267897-w4pbq2lb	279	1	It	-PRON-	PRP
cord-267897-w4pbq2lb	279	2	remains	remain	VBZ
cord-267897-w4pbq2lb	279	3	to	to	TO
cord-267897-w4pbq2lb	279	4	be	be	VB
cord-267897-w4pbq2lb	279	5	established	establish	VBN
cord-267897-w4pbq2lb	279	6	if	if	IN
cord-267897-w4pbq2lb	279	7	other	other	JJ
cord-267897-w4pbq2lb	279	8	danger	danger	NN
cord-267897-w4pbq2lb	279	9	signals	signal	NNS
cord-267897-w4pbq2lb	279	10	,	,	,
cord-267897-w4pbq2lb	279	11	such	such	JJ
cord-267897-w4pbq2lb	279	12	as	as	IN
cord-267897-w4pbq2lb	279	13	HSP70	HSP70	NNP
cord-267897-w4pbq2lb	279	14	(	(	-LRB-
cord-267897-w4pbq2lb	279	15	a	a	DT
cord-267897-w4pbq2lb	279	16	70	70	CD
cord-267897-w4pbq2lb	279	17	kDa	kDa	NNP
cord-267897-w4pbq2lb	279	18	heat	heat	NN
cord-267897-w4pbq2lb	279	19	shock	shock	NN
cord-267897-w4pbq2lb	279	20	protein	protein	NN
cord-267897-w4pbq2lb	279	21	)	)	-RRB-
cord-267897-w4pbq2lb	279	22	also	also	RB
cord-267897-w4pbq2lb	279	23	lead	lead	VBP
cord-267897-w4pbq2lb	279	24	to	to	IN
cord-267897-w4pbq2lb	279	25	the	the	DT
cord-267897-w4pbq2lb	279	26	stimulation	stimulation	NN
cord-267897-w4pbq2lb	279	27	of	of	IN
cord-267897-w4pbq2lb	279	28	the	the	DT
cord-267897-w4pbq2lb	279	29	NALP3	NALP3	NNP
cord-267897-w4pbq2lb	279	30	inflammasome	inflammasome	NNP
cord-267897-w4pbq2lb	279	31	,	,	,
cord-267897-w4pbq2lb	279	32	but	but	CC
cord-267897-w4pbq2lb	279	33	there	there	EX
cord-267897-w4pbq2lb	279	34	are	be	VBP
cord-267897-w4pbq2lb	279	35	some	some	DT
cord-267897-w4pbq2lb	279	36	indications	indication	NNS
cord-267897-w4pbq2lb	279	37	that	that	IN
cord-267897-w4pbq2lb	279	38	it	-PRON-	PRP
cord-267897-w4pbq2lb	279	39	may	may	MD
cord-267897-w4pbq2lb	279	40	be	be	VB
cord-267897-w4pbq2lb	279	41	the	the	DT
cord-267897-w4pbq2lb	279	42	case	case	NN
cord-267897-w4pbq2lb	279	43	.	.	.
cord-267897-w4pbq2lb	280	1	One	one	CD
cord-267897-w4pbq2lb	280	2	observation	observation	NN
cord-267897-w4pbq2lb	280	3	considered	consider	VBD
cord-267897-w4pbq2lb	280	4	supportive	supportive	JJ
cord-267897-w4pbq2lb	280	5	was	be	VBD
cord-267897-w4pbq2lb	280	6	reported	report	VBN
cord-267897-w4pbq2lb	280	7	by	by	IN
cord-267897-w4pbq2lb	280	8	Alexzander	Alexzander	NNP
cord-267897-w4pbq2lb	280	9	Asea	Asea	NNP
cord-267897-w4pbq2lb	280	10	's	's	POS
cord-267897-w4pbq2lb	280	11	group	group	NN
cord-267897-w4pbq2lb	280	12	from	from	IN
cord-267897-w4pbq2lb	280	13	the	the	DT
cord-267897-w4pbq2lb	280	14	Harvard	Harvard	NNP
cord-267897-w4pbq2lb	280	15	Medical	Medical	NNP
cord-267897-w4pbq2lb	280	16	School	School	NNP
cord-267897-w4pbq2lb	280	17	.	.	.
cord-267897-w4pbq2lb	281	1	They	-PRON-	PRP
cord-267897-w4pbq2lb	281	2	demonstrated	demonstrate	VBD
cord-267897-w4pbq2lb	281	3	that	that	IN
cord-267897-w4pbq2lb	281	4	extracellular	extracellular	JJ
cord-267897-w4pbq2lb	281	5	HSP70	HSP70	NNP
cord-267897-w4pbq2lb	281	6	added	add	VBD
cord-267897-w4pbq2lb	281	7	to	to	IN
cord-267897-w4pbq2lb	281	8	human	human	JJ
cord-267897-w4pbq2lb	281	9	monocyte	monocyte	NNP
cord-267897-w4pbq2lb	281	10	cultures	culture	NNS
cord-267897-w4pbq2lb	281	11	elicited	elicit	VBD
cord-267897-w4pbq2lb	281	12	a	a	DT
cord-267897-w4pbq2lb	281	13	rapid	rapid	JJ
cord-267897-w4pbq2lb	281	14	intracellular	intracellular	JJ
cord-267897-w4pbq2lb	281	15	Ca	Ca	NNP
cord-267897-w4pbq2lb	281	16	þþ	þþ	IN
cord-267897-w4pbq2lb	281	17	flux	flux	NN
cord-267897-w4pbq2lb	281	18	,	,	,
cord-267897-w4pbq2lb	281	19	activated	activate	VBN
cord-267897-w4pbq2lb	281	20	nuclear	nuclear	JJ
cord-267897-w4pbq2lb	281	21	factor	factor	NN
cord-267897-w4pbq2lb	281	22	NF	NF	NNP
cord-267897-w4pbq2lb	281	23	-	-	HYPH
cord-267897-w4pbq2lb	281	24	kB	kB	NNP
cord-267897-w4pbq2lb	281	25	,	,	,
cord-267897-w4pbq2lb	281	26	and	and	CC
cord-267897-w4pbq2lb	281	27	upregulated	upregulate	VBD
cord-267897-w4pbq2lb	281	28	the	the	DT
cord-267897-w4pbq2lb	281	29	expression	expression	NN
cord-267897-w4pbq2lb	281	30	of	of	IN
cord-267897-w4pbq2lb	281	31	proinflammatory	proinflammatory	JJ
cord-267897-w4pbq2lb	281	32	cytokines	cytokine	NNS
cord-267897-w4pbq2lb	281	33	,	,	,
cord-267897-w4pbq2lb	281	34	TNF	TNF	NNP
cord-267897-w4pbq2lb	281	35	-	-	HYPH
cord-267897-w4pbq2lb	281	36	a	a	NNP
cord-267897-w4pbq2lb	281	37	,	,	,
cord-267897-w4pbq2lb	281	38	IL-1b	IL-1b	NNP
cord-267897-w4pbq2lb	281	39	,	,	,
cord-267897-w4pbq2lb	281	40	and	and	CC
cord-267897-w4pbq2lb	281	41	IL-6	IL-6	NNP
cord-267897-w4pbq2lb	281	42	.	.	.
cord-267897-w4pbq2lb	281	43	93	93	CD
cord-267897-w4pbq2lb	282	1	In	in	IN
cord-267897-w4pbq2lb	282	2	a	a	DT
cord-267897-w4pbq2lb	282	3	follow	follow	NN
cord-267897-w4pbq2lb	282	4	-	-	HYPH
cord-267897-w4pbq2lb	282	5	up	up	NN
cord-267897-w4pbq2lb	282	6	study	study	NN
cord-267897-w4pbq2lb	282	7	,	,	,
cord-267897-w4pbq2lb	282	8	they	-PRON-	PRP
cord-267897-w4pbq2lb	282	9	demonstrated	demonstrate	VBD
cord-267897-w4pbq2lb	282	10	that	that	IN
cord-267897-w4pbq2lb	282	11	HSP70	HSP70	NNP
cord-267897-w4pbq2lb	282	12	utilized	utilize	VBD
cord-267897-w4pbq2lb	282	13	both	both	CC
cord-267897-w4pbq2lb	282	14	the	the	DT
cord-267897-w4pbq2lb	282	15	TLR2	TLR2	NNP
cord-267897-w4pbq2lb	282	16	and	and	CC
cord-267897-w4pbq2lb	282	17	TLR4	TLR4	NNP
cord-267897-w4pbq2lb	282	18	receptors	receptor	NNS
cord-267897-w4pbq2lb	282	19	for	for	IN
cord-267897-w4pbq2lb	282	20	proinflammatory	proinflammatory	JJ
cord-267897-w4pbq2lb	282	21	signal	signal	NN
cord-267897-w4pbq2lb	282	22	transduction	transduction	NN
cord-267897-w4pbq2lb	282	23	in	in	IN
cord-267897-w4pbq2lb	282	24	a	a	DT
cord-267897-w4pbq2lb	282	25	CD14-dependent	cd14-dependent	CD
cord-267897-w4pbq2lb	282	26	fashion	fashion	NN
cord-267897-w4pbq2lb	282	27	.	.	.
cord-267897-w4pbq2lb	283	1	94	94	CD
cord-267897-w4pbq2lb	283	2	 	 	_SP
cord-267897-w4pbq2lb	284	1	A	a	DT
cord-267897-w4pbq2lb	284	2	study	study	NN
cord-267897-w4pbq2lb	284	3	of	of	IN
cord-267897-w4pbq2lb	284	4	the	the	DT
cord-267897-w4pbq2lb	284	5	literature	literature	NN
cord-267897-w4pbq2lb	284	6	suggests	suggest	VBZ
cord-267897-w4pbq2lb	284	7	a	a	DT
cord-267897-w4pbq2lb	284	8	difference	difference	NN
cord-267897-w4pbq2lb	284	9	in	in	IN
cord-267897-w4pbq2lb	284	10	the	the	DT
cord-267897-w4pbq2lb	284	11	profile	profile	NN
cord-267897-w4pbq2lb	284	12	related	relate	VBN
cord-267897-w4pbq2lb	284	13	to	to	IN
cord-267897-w4pbq2lb	284	14	stimulation	stimulation	NN
cord-267897-w4pbq2lb	284	15	of	of	IN
cord-267897-w4pbq2lb	284	16	IgE	IgE	NNP
cord-267897-w4pbq2lb	284	17	between	between	IN
cord-267897-w4pbq2lb	284	18	the	the	DT
cord-267897-w4pbq2lb	284	19	aluminum	aluminum	NN
cord-267897-w4pbq2lb	284	20	-	-	HYPH
cord-267897-w4pbq2lb	284	21	and	and	CC
cord-267897-w4pbq2lb	284	22	calcium	calcium	NN
cord-267897-w4pbq2lb	284	23	-	-	HYPH
cord-267897-w4pbq2lb	284	24	based	base	VBN
cord-267897-w4pbq2lb	284	25	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	284	26	.	.	.
cord-267897-w4pbq2lb	285	1	The	the	DT
cord-267897-w4pbq2lb	285	2	ability	ability	NN
cord-267897-w4pbq2lb	285	3	of	of	IN
cord-267897-w4pbq2lb	285	4	aluminum	aluminum	NN
cord-267897-w4pbq2lb	285	5	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	285	6	to	to	TO
cord-267897-w4pbq2lb	285	7	stimulate	stimulate	VB
cord-267897-w4pbq2lb	285	8	the	the	DT
cord-267897-w4pbq2lb	285	9	production	production	NN
cord-267897-w4pbq2lb	285	10	of	of	IN
cord-267897-w4pbq2lb	285	11	IgE	IgE	NNP
cord-267897-w4pbq2lb	285	12	as	as	IN
cord-267897-w4pbq2lb	285	13	part	part	NN
cord-267897-w4pbq2lb	285	14	of	of	IN
cord-267897-w4pbq2lb	285	15	the	the	DT
cord-267897-w4pbq2lb	285	16	overall	overall	JJ
cord-267897-w4pbq2lb	285	17	Th2	th2	CD
cord-267897-w4pbq2lb	285	18	profile	profile	NN
cord-267897-w4pbq2lb	285	19	is	be	VBZ
cord-267897-w4pbq2lb	285	20	well	well	RB
cord-267897-w4pbq2lb	285	21	-	-	HYPH
cord-267897-w4pbq2lb	285	22	established	establish	VBN
cord-267897-w4pbq2lb	285	23	.	.	.
cord-267897-w4pbq2lb	286	1	95	95	CD
cord-267897-w4pbq2lb	286	2	,	,	,
cord-267897-w4pbq2lb	286	3	96	96	CD
cord-267897-w4pbq2lb	287	1	Although	although	IN
cord-267897-w4pbq2lb	287	2	this	this	DT
cord-267897-w4pbq2lb	287	3	has	have	VBZ
cord-267897-w4pbq2lb	287	4	often	often	RB
cord-267897-w4pbq2lb	287	5	been	be	VBN
cord-267897-w4pbq2lb	287	6	mentioned	mention	VBN
cord-267897-w4pbq2lb	287	7	as	as	IN
cord-267897-w4pbq2lb	287	8	a	a	DT
cord-267897-w4pbq2lb	287	9	disadvantage	disadvantage	NN
cord-267897-w4pbq2lb	287	10	,	,	,
cord-267897-w4pbq2lb	287	11	it	-PRON-	PRP
cord-267897-w4pbq2lb	287	12	has	have	VBZ
cord-267897-w4pbq2lb	287	13	been	be	VBN
cord-267897-w4pbq2lb	287	14	difficult	difficult	JJ
cord-267897-w4pbq2lb	287	15	to	to	TO
cord-267897-w4pbq2lb	287	16	demonstrate	demonstrate	VB
cord-267897-w4pbq2lb	287	17	cases	case	NNS
cord-267897-w4pbq2lb	287	18	in	in	IN
cord-267897-w4pbq2lb	287	19	which	which	WDT
cord-267897-w4pbq2lb	287	20	vaccination	vaccination	NN
cord-267897-w4pbq2lb	287	21	with	with	IN
cord-267897-w4pbq2lb	287	22	aluminum	aluminum	NN
cord-267897-w4pbq2lb	287	23	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	287	24	has	have	VBZ
cord-267897-w4pbq2lb	287	25	led	lead	VBN
cord-267897-w4pbq2lb	287	26	to	to	IN
cord-267897-w4pbq2lb	287	27	IgE	IgE	NNP
cord-267897-w4pbq2lb	287	28	-	-	HYPH
cord-267897-w4pbq2lb	287	29	mediated	mediate	VBN
cord-267897-w4pbq2lb	287	30	allergy	allergy	NN
cord-267897-w4pbq2lb	287	31	toward	toward	IN
cord-267897-w4pbq2lb	287	32	the	the	DT
cord-267897-w4pbq2lb	287	33	vaccine	vaccine	NN
cord-267897-w4pbq2lb	287	34	antigen	antigen	NN
cord-267897-w4pbq2lb	287	35	in	in	IN
cord-267897-w4pbq2lb	287	36	practical	practical	JJ
cord-267897-w4pbq2lb	287	37	vaccination	vaccination	NN
cord-267897-w4pbq2lb	287	38	.	.	.
cord-267897-w4pbq2lb	288	1	In	in	IN
cord-267897-w4pbq2lb	288	2	contrast	contrast	NN
cord-267897-w4pbq2lb	288	3	,	,	,
cord-267897-w4pbq2lb	288	4	aluminum	aluminum	NN
cord-267897-w4pbq2lb	288	5	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	288	6	have	have	VBP
cord-267897-w4pbq2lb	288	7	been	be	VBN
cord-267897-w4pbq2lb	288	8	used	use	VBN
cord-267897-w4pbq2lb	288	9	to	to	TO
cord-267897-w4pbq2lb	288	10	hyposensitize	hyposensitize	VB
cord-267897-w4pbq2lb	288	11	allergic	allergic	JJ
cord-267897-w4pbq2lb	288	12	patients	patient	NNS
cord-267897-w4pbq2lb	288	13	for	for	IN
cord-267897-w4pbq2lb	288	14	many	many	JJ
cord-267897-w4pbq2lb	288	15	years	year	NNS
cord-267897-w4pbq2lb	288	16	with	with	IN
cord-267897-w4pbq2lb	288	17	good	good	JJ
cord-267897-w4pbq2lb	288	18	results	result	NNS
cord-267897-w4pbq2lb	288	19	,	,	,
cord-267897-w4pbq2lb	288	20	e.g.	e.g.	RB
cord-267897-w4pbq2lb	288	21	,	,	,
cord-267897-w4pbq2lb	288	22	with	with	IN
cord-267897-w4pbq2lb	288	23	the	the	DT
cord-267897-w4pbq2lb	288	24	ALUTARD	ALUTARD	NNP
cord-267897-w4pbq2lb	288	25	series	series	NN
cord-267897-w4pbq2lb	288	26	of	of	IN
cord-267897-w4pbq2lb	288	27	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	288	28	(	(	-LRB-
cord-267897-w4pbq2lb	288	29	Table	table	NN
cord-267897-w4pbq2lb	288	30	18	18	CD
cord-267897-w4pbq2lb	288	31	.1	.1	CD
cord-267897-w4pbq2lb	288	32	)	)	-RRB-
cord-267897-w4pbq2lb	288	33	.	.	.
cord-267897-w4pbq2lb	289	1	Much	much	JJ
cord-267897-w4pbq2lb	289	2	of	of	IN
cord-267897-w4pbq2lb	289	3	the	the	DT
cord-267897-w4pbq2lb	289	4	work	work	NN
cord-267897-w4pbq2lb	289	5	on	on	IN
cord-267897-w4pbq2lb	289	6	the	the	DT
cord-267897-w4pbq2lb	289	7	IgE	IgE	NNP
cord-267897-w4pbq2lb	289	8	stimulation	stimulation	NN
cord-267897-w4pbq2lb	289	9	by	by	IN
cord-267897-w4pbq2lb	289	10	aluminum	aluminum	NN
cord-267897-w4pbq2lb	289	11	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	289	12	in	in	IN
cord-267897-w4pbq2lb	289	13	animal	animal	NN
cord-267897-w4pbq2lb	289	14	models	model	NNS
cord-267897-w4pbq2lb	289	15	has	have	VBZ
cord-267897-w4pbq2lb	289	16	been	be	VBN
cord-267897-w4pbq2lb	289	17	carried	carry	VBN
cord-267897-w4pbq2lb	289	18	out	out	RP
cord-267897-w4pbq2lb	289	19	using	use	VBG
cord-267897-w4pbq2lb	289	20	a	a	DT
cord-267897-w4pbq2lb	289	21	dual	dual	JJ
cord-267897-w4pbq2lb	289	22	setup	setup	NN
cord-267897-w4pbq2lb	289	23	model	model	NN
cord-267897-w4pbq2lb	289	24	in	in	IN
cord-267897-w4pbq2lb	289	25	which	which	WDT
cord-267897-w4pbq2lb	289	26	rodents	rodent	NNS
cord-267897-w4pbq2lb	289	27	were	be	VBD
cord-267897-w4pbq2lb	289	28	immunized	immunize	VBN
cord-267897-w4pbq2lb	289	29	using	use	VBG
cord-267897-w4pbq2lb	289	30	either	either	CC
cord-267897-w4pbq2lb	289	31	aluminum	aluminum	NN
cord-267897-w4pbq2lb	289	32	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	289	33	or	or	CC
cord-267897-w4pbq2lb	289	34	FCA	FCA	NNP
cord-267897-w4pbq2lb	289	35	,	,	,
cord-267897-w4pbq2lb	289	36	respectively	respectively	RB
cord-267897-w4pbq2lb	289	37	,	,	,
cord-267897-w4pbq2lb	289	38	and	and	CC
cord-267897-w4pbq2lb	289	39	antibody	antibody	NN
cord-267897-w4pbq2lb	289	40	and	and	CC
cord-267897-w4pbq2lb	289	41	cytokine	cytokine	NN
cord-267897-w4pbq2lb	289	42	profiles	profile	NNS
cord-267897-w4pbq2lb	289	43	were	be	VBD
cord-267897-w4pbq2lb	289	44	compared	compare	VBN
cord-267897-w4pbq2lb	289	45	.	.	.
cord-267897-w4pbq2lb	290	1	Uede	Uede	NNP
cord-267897-w4pbq2lb	290	2	and	and	CC
cord-267897-w4pbq2lb	290	3	coworkers	coworker	NNS
cord-267897-w4pbq2lb	290	4	in	in	IN
cord-267897-w4pbq2lb	290	5	Japan	Japan	NNP
cord-267897-w4pbq2lb	290	6	97,98	97,98	CD
cord-267897-w4pbq2lb	290	7	pioneered	pioneer	VBD
cord-267897-w4pbq2lb	290	8	this	this	DT
cord-267897-w4pbq2lb	290	9	line	line	NN
cord-267897-w4pbq2lb	290	10	of	of	IN
cord-267897-w4pbq2lb	290	11	research	research	NN
cord-267897-w4pbq2lb	290	12	three	three	CD
cord-267897-w4pbq2lb	290	13	decades	decade	NNS
cord-267897-w4pbq2lb	290	14	ago	ago	RB
cord-267897-w4pbq2lb	290	15	using	use	VBG
cord-267897-w4pbq2lb	290	16	keyhole	keyhole	NN
cord-267897-w4pbq2lb	290	17	limpet	limpet	NNP
cord-267897-w4pbq2lb	290	18	hemocyanin	hemocyanin	NN
cord-267897-w4pbq2lb	290	19	as	as	IN
cord-267897-w4pbq2lb	290	20	antigen	antigen	NN
cord-267897-w4pbq2lb	290	21	and	and	CC
cord-267897-w4pbq2lb	290	22	demonstrated	demonstrate	VBD
cord-267897-w4pbq2lb	290	23	the	the	DT
cord-267897-w4pbq2lb	290	24	involvement	involvement	NN
cord-267897-w4pbq2lb	290	25	glycosylation	glycosylation	NN
cord-267897-w4pbq2lb	290	26	-	-	HYPH
cord-267897-w4pbq2lb	290	27	enhancing	enhance	VBG
cord-267897-w4pbq2lb	290	28	factors	factor	NNS
cord-267897-w4pbq2lb	290	29	and	and	CC
cord-267897-w4pbq2lb	290	30	Fc	Fc	NNP
cord-267897-w4pbq2lb	290	31	g	g	NN
cord-267897-w4pbq2lb	290	32	R	r	NN
cord-267897-w4pbq2lb	290	33	þ	þ	NN
cord-267897-w4pbq2lb	290	34	T	t	NN
cord-267897-w4pbq2lb	290	35	cells	cell	NNS
cord-267897-w4pbq2lb	290	36	in	in	IN
cord-267897-w4pbq2lb	290	37	a	a	DT
cord-267897-w4pbq2lb	290	38	dichotomous	dichotomous	JJ
cord-267897-w4pbq2lb	290	39	regulatory	regulatory	JJ
cord-267897-w4pbq2lb	290	40	pathway	pathway	NN
cord-267897-w4pbq2lb	290	41	where	where	WRB
cord-267897-w4pbq2lb	290	42	aluminum	aluminum	NN
cord-267897-w4pbq2lb	290	43	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	290	44	stimulated	stimulate	VBD
cord-267897-w4pbq2lb	290	45	the	the	DT
cord-267897-w4pbq2lb	290	46	synthesis	synthesis	NN
cord-267897-w4pbq2lb	290	47	of	of	IN
cord-267897-w4pbq2lb	290	48	IgE	IgE	NNP
cord-267897-w4pbq2lb	290	49	,	,	,
cord-267897-w4pbq2lb	290	50	whereas	whereas	IN
cord-267897-w4pbq2lb	290	51	FCA	FCA	NNP
cord-267897-w4pbq2lb	290	52	suppressed	suppress	VBD
cord-267897-w4pbq2lb	290	53	it	-PRON-	PRP
cord-267897-w4pbq2lb	290	54	.	.	.
cord-267897-w4pbq2lb	291	1	Brewer	brewer	NN
cord-267897-w4pbq2lb	291	2	and	and	CC
cord-267897-w4pbq2lb	291	3	coworkers	coworker	NNS
cord-267897-w4pbq2lb	291	4	81	81	CD
cord-267897-w4pbq2lb	291	5	used	use	VBD
cord-267897-w4pbq2lb	291	6	the	the	DT
cord-267897-w4pbq2lb	291	7	same	same	JJ
cord-267897-w4pbq2lb	291	8	approach	approach	NN
cord-267897-w4pbq2lb	291	9	of	of	IN
cord-267897-w4pbq2lb	291	10	comparing	compare	VBG
cord-267897-w4pbq2lb	291	11	the	the	DT
cord-267897-w4pbq2lb	291	12	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	291	13	profiles	profile	NNS
cord-267897-w4pbq2lb	291	14	of	of	IN
cord-267897-w4pbq2lb	291	15	aluminum	aluminum	NN
cord-267897-w4pbq2lb	291	16	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	291	17	vs	vs	IN
cord-267897-w4pbq2lb	291	18	FCA	FCA	NNP
cord-267897-w4pbq2lb	291	19	using	use	VBG
cord-267897-w4pbq2lb	291	20	gene	gene	NN
cord-267897-w4pbq2lb	291	21	-	-	HYPH
cord-267897-w4pbq2lb	291	22	disrupted	disrupt	VBN
cord-267897-w4pbq2lb	291	23	mice	mouse	NNS
cord-267897-w4pbq2lb	291	24	.	.	.
cord-267897-w4pbq2lb	292	1	They	-PRON-	PRP
cord-267897-w4pbq2lb	292	2	found	find	VBD
cord-267897-w4pbq2lb	292	3	that	that	IN
cord-267897-w4pbq2lb	292	4	there	there	EX
cord-267897-w4pbq2lb	292	5	was	be	VBD
cord-267897-w4pbq2lb	292	6	no	no	DT
cord-267897-w4pbq2lb	292	7	IgE	ige	NN
cord-267897-w4pbq2lb	292	8	production	production	NN
cord-267897-w4pbq2lb	292	9	in	in	IN
cord-267897-w4pbq2lb	292	10	IL-4	IL-4	NNP
cord-267897-w4pbq2lb	292	11	gene	gene	NN
cord-267897-w4pbq2lb	292	12	-	-	HYPH
cord-267897-w4pbq2lb	292	13	disrupted	disrupt	VBN
cord-267897-w4pbq2lb	292	14	mice	mouse	NNS
cord-267897-w4pbq2lb	292	15	(	(	-LRB-
cord-267897-w4pbq2lb	292	16	IL-4	IL-4	NNP
cord-267897-w4pbq2lb	292	17	À	À	NNP
cord-267897-w4pbq2lb	292	18	/	/	SYM
cord-267897-w4pbq2lb	292	19	À	à	NN
cord-267897-w4pbq2lb	292	20	)	)	-RRB-
cord-267897-w4pbq2lb	292	21	regardless	regardless	RB
cord-267897-w4pbq2lb	292	22	of	of	IN
cord-267897-w4pbq2lb	292	23	whether	whether	IN
cord-267897-w4pbq2lb	292	24	aluminum	aluminum	NN
cord-267897-w4pbq2lb	292	25	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	292	26	or	or	CC
cord-267897-w4pbq2lb	292	27	FCA	FCA	NNP
cord-267897-w4pbq2lb	292	28	was	be	VBD
cord-267897-w4pbq2lb	292	29	used	use	VBN
cord-267897-w4pbq2lb	292	30	as	as	IN
cord-267897-w4pbq2lb	292	31	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	292	32	.	.	.
cord-267897-w4pbq2lb	293	1	This	this	DT
cord-267897-w4pbq2lb	293	2	suggests	suggest	VBZ
cord-267897-w4pbq2lb	293	3	that	that	IN
cord-267897-w4pbq2lb	293	4	IL-4	IL-4	NNP
cord-267897-w4pbq2lb	293	5	is	be	VBZ
cord-267897-w4pbq2lb	293	6	an	an	DT
cord-267897-w4pbq2lb	293	7	essential	essential	JJ
cord-267897-w4pbq2lb	293	8	prerequisite	prerequisite	NN
cord-267897-w4pbq2lb	293	9	for	for	IN
cord-267897-w4pbq2lb	293	10	the	the	DT
cord-267897-w4pbq2lb	293	11	induction	induction	NN
cord-267897-w4pbq2lb	293	12	of	of	IN
cord-267897-w4pbq2lb	293	13	IgE	IgE	NNP
cord-267897-w4pbq2lb	293	14	by	by	IN
cord-267897-w4pbq2lb	293	15	aluminum	aluminum	NN
cord-267897-w4pbq2lb	293	16	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	293	17	.	.	.
cord-267897-w4pbq2lb	294	1	The	the	DT
cord-267897-w4pbq2lb	294	2	literature	literature	NN
cord-267897-w4pbq2lb	294	3	data	datum	NNS
cord-267897-w4pbq2lb	294	4	suggest	suggest	VBP
cord-267897-w4pbq2lb	294	5	that	that	IN
cord-267897-w4pbq2lb	294	6	the	the	DT
cord-267897-w4pbq2lb	294	7	calcium	calcium	NN
cord-267897-w4pbq2lb	294	8	phosphate	phosphate	NN
cord-267897-w4pbq2lb	294	9	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	294	10	does	do	VBZ
cord-267897-w4pbq2lb	294	11	not	not	RB
cord-267897-w4pbq2lb	294	12	lead	lead	VB
cord-267897-w4pbq2lb	294	13	to	to	IN
cord-267897-w4pbq2lb	294	14	significant	significant	JJ
cord-267897-w4pbq2lb	294	15	stimulation	stimulation	NN
cord-267897-w4pbq2lb	294	16	of	of	IN
cord-267897-w4pbq2lb	294	17	IgE	IgE	NNP
cord-267897-w4pbq2lb	294	18	antibodies	antibody	NNS
cord-267897-w4pbq2lb	294	19	.	.	.
cord-267897-w4pbq2lb	295	1	Vassilev	Vassilev	NNP
cord-267897-w4pbq2lb	295	2	99	99	CD
cord-267897-w4pbq2lb	295	3	compared	compare	VBN
cord-267897-w4pbq2lb	295	4	passive	passive	JJ
cord-267897-w4pbq2lb	295	5	cutaneous	cutaneous	JJ
cord-267897-w4pbq2lb	295	6	anaphylaxia	anaphylaxia	NN
cord-267897-w4pbq2lb	295	7	in	in	IN
cord-267897-w4pbq2lb	295	8	guinea	guinea	NN
cord-267897-w4pbq2lb	295	9	pigs	pig	NNS
cord-267897-w4pbq2lb	295	10	after	after	IN
cord-267897-w4pbq2lb	295	11	two	two	CD
cord-267897-w4pbq2lb	295	12	immunizations	immunization	NNS
cord-267897-w4pbq2lb	295	13	with	with	IN
cord-267897-w4pbq2lb	295	14	either	either	CC
cord-267897-w4pbq2lb	295	15	aluminum	aluminum	NN
cord-267897-w4pbq2lb	295	16	or	or	CC
cord-267897-w4pbq2lb	295	17	calcium	calcium	NN
cord-267897-w4pbq2lb	295	18	phosphate	phosphate	NN
cord-267897-w4pbq2lb	295	19	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	295	20	using	use	VBG
cord-267897-w4pbq2lb	295	21	tetanus	tetanus	JJ
cord-267897-w4pbq2lb	295	22	toxoid	toxoid	NN
cord-267897-w4pbq2lb	295	23	as	as	IN
cord-267897-w4pbq2lb	295	24	antigen	antigen	NN
cord-267897-w4pbq2lb	295	25	.	.	.
cord-267897-w4pbq2lb	296	1	He	-PRON-	PRP
cord-267897-w4pbq2lb	296	2	found	find	VBD
cord-267897-w4pbq2lb	296	3	that	that	IN
cord-267897-w4pbq2lb	296	4	calcium	calcium	NN
cord-267897-w4pbq2lb	296	5	phosphateeadjuvanted	phosphateeadjuvante	VBN
cord-267897-w4pbq2lb	296	6	guinea	guinea	NN
cord-267897-w4pbq2lb	296	7	pigs	pig	NNS
cord-267897-w4pbq2lb	296	8	only	only	RB
cord-267897-w4pbq2lb	296	9	had	have	VBD
cord-267897-w4pbq2lb	296	10	insignificant	insignificant	JJ
cord-267897-w4pbq2lb	296	11	IgE	IgE	NNP
cord-267897-w4pbq2lb	296	12	titers	titer	NNS
cord-267897-w4pbq2lb	296	13	compared	compare	VBN
cord-267897-w4pbq2lb	296	14	with	with	IN
cord-267897-w4pbq2lb	296	15	the	the	DT
cord-267897-w4pbq2lb	296	16	group	group	NN
cord-267897-w4pbq2lb	296	17	that	that	WDT
cord-267897-w4pbq2lb	296	18	had	have	VBD
cord-267897-w4pbq2lb	296	19	received	receive	VBN
cord-267897-w4pbq2lb	296	20	Al	Al	NNP
cord-267897-w4pbq2lb	296	21	-	-	HYPH
cord-267897-w4pbq2lb	296	22	adjuvanted	adjuvante	VBN
cord-267897-w4pbq2lb	296	23	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	296	24	.	.	.
cord-267897-w4pbq2lb	297	1	In	in	IN
cord-267897-w4pbq2lb	297	2	general	general	JJ
cord-267897-w4pbq2lb	297	3	,	,	,
cord-267897-w4pbq2lb	297	4	the	the	DT
cord-267897-w4pbq2lb	297	5	research	research	NN
cord-267897-w4pbq2lb	297	6	in	in	IN
cord-267897-w4pbq2lb	297	7	this	this	DT
cord-267897-w4pbq2lb	297	8	field	field	NN
cord-267897-w4pbq2lb	297	9	is	be	VBZ
cord-267897-w4pbq2lb	297	10	sparse	sparse	JJ
cord-267897-w4pbq2lb	297	11	and	and	CC
cord-267897-w4pbq2lb	297	12	there	there	EX
cord-267897-w4pbq2lb	297	13	are	be	VBP
cord-267897-w4pbq2lb	297	14	at	at	IN
cord-267897-w4pbq2lb	297	15	present	present	JJ
cord-267897-w4pbq2lb	297	16	no	no	DT
cord-267897-w4pbq2lb	297	17	data	datum	NNS
cord-267897-w4pbq2lb	297	18	on	on	IN
cord-267897-w4pbq2lb	297	19	the	the	DT
cord-267897-w4pbq2lb	297	20	interleukin	interleukin	NN
cord-267897-w4pbq2lb	297	21	profile	profile	NN
cord-267897-w4pbq2lb	297	22	after	after	IN
cord-267897-w4pbq2lb	297	23	immunization	immunization	NN
cord-267897-w4pbq2lb	297	24	with	with	IN
cord-267897-w4pbq2lb	297	25	calcium	calcium	NN
cord-267897-w4pbq2lb	297	26	phosphate	phosphate	NN
cord-267897-w4pbq2lb	297	27	to	to	TO
cord-267897-w4pbq2lb	297	28	illustrate	illustrate	VB
cord-267897-w4pbq2lb	297	29	possible	possible	JJ
cord-267897-w4pbq2lb	297	30	underlying	underlying	JJ
cord-267897-w4pbq2lb	297	31	differences	difference	NNS
cord-267897-w4pbq2lb	297	32	in	in	IN
cord-267897-w4pbq2lb	297	33	the	the	DT
cord-267897-w4pbq2lb	297	34	mechanisms	mechanism	NNS
cord-267897-w4pbq2lb	297	35	behind	behind	IN
cord-267897-w4pbq2lb	297	36	such	such	PDT
cord-267897-w4pbq2lb	297	37	a	a	DT
cord-267897-w4pbq2lb	297	38	difference	difference	NN
cord-267897-w4pbq2lb	297	39	.	.	.
cord-267897-w4pbq2lb	298	1	There	there	EX
cord-267897-w4pbq2lb	298	2	are	be	VBP
cord-267897-w4pbq2lb	298	3	some	some	DT
cord-267897-w4pbq2lb	298	4	interesting	interesting	JJ
cord-267897-w4pbq2lb	298	5	similarities	similarity	NNS
cord-267897-w4pbq2lb	298	6	between	between	IN
cord-267897-w4pbq2lb	298	7	the	the	DT
cord-267897-w4pbq2lb	298	8	immune	immune	JJ
cord-267897-w4pbq2lb	298	9	response	response	NN
cord-267897-w4pbq2lb	298	10	(	(	-LRB-
cord-267897-w4pbq2lb	298	11	e.g.	e.g.	RB
cord-267897-w4pbq2lb	298	12	,	,	,
cord-267897-w4pbq2lb	298	13	stimulation	stimulation	NN
cord-267897-w4pbq2lb	298	14	of	of	IN
cord-267897-w4pbq2lb	298	15	IgE	IgE	NNP
cord-267897-w4pbq2lb	298	16	and	and	CC
cord-267897-w4pbq2lb	298	17	eosinophilia	eosinophilia	NNP
cord-267897-w4pbq2lb	298	18	)	)	-RRB-
cord-267897-w4pbq2lb	298	19	elicited	elicit	VBN
cord-267897-w4pbq2lb	298	20	by	by	IN
cord-267897-w4pbq2lb	298	21	some	some	DT
cord-267897-w4pbq2lb	298	22	helminthic	helminthic	JJ
cord-267897-w4pbq2lb	298	23	parasites	parasite	NNS
cord-267897-w4pbq2lb	298	24	and	and	CC
cord-267897-w4pbq2lb	298	25	the	the	DT
cord-267897-w4pbq2lb	298	26	immune	immune	JJ
cord-267897-w4pbq2lb	298	27	response	response	NN
cord-267897-w4pbq2lb	298	28	following	follow	VBG
cord-267897-w4pbq2lb	298	29	immunization	immunization	NN
cord-267897-w4pbq2lb	298	30	with	with	IN
cord-267897-w4pbq2lb	298	31	aluminum	aluminum	NN
cord-267897-w4pbq2lb	298	32	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	298	33	that	that	WDT
cord-267897-w4pbq2lb	298	34	makes	make	VBZ
cord-267897-w4pbq2lb	298	35	these	these	DT
cord-267897-w4pbq2lb	298	36	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	298	37	interesting	interesting	JJ
cord-267897-w4pbq2lb	298	38	candidates	candidate	NNS
cord-267897-w4pbq2lb	298	39	for	for	IN
cord-267897-w4pbq2lb	298	40	antiparasitic	antiparasitic	JJ
cord-267897-w4pbq2lb	298	41	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	298	42	.	.	.
cord-267897-w4pbq2lb	299	1	Early	early	JJ
cord-267897-w4pbq2lb	299	2	experimental	experimental	JJ
cord-267897-w4pbq2lb	299	3	data	datum	NNS
cord-267897-w4pbq2lb	299	4	suggested	suggest	VBD
cord-267897-w4pbq2lb	299	5	a	a	DT
cord-267897-w4pbq2lb	299	6	protective	protective	JJ
cord-267897-w4pbq2lb	299	7	superiority	superiority	NN
cord-267897-w4pbq2lb	299	8	of	of	IN
cord-267897-w4pbq2lb	299	9	specific	specific	JJ
cord-267897-w4pbq2lb	299	10	IgE	IgE	NNP
cord-267897-w4pbq2lb	299	11	after	after	IN
cord-267897-w4pbq2lb	299	12	aluminum	aluminum	NN
cord-267897-w4pbq2lb	299	13	-	-	HYPH
cord-267897-w4pbq2lb	299	14	adjuvanted	adjuvante	VBN
cord-267897-w4pbq2lb	299	15	vaccination	vaccination	NN
cord-267897-w4pbq2lb	299	16	in	in	IN
cord-267897-w4pbq2lb	299	17	animal	animal	NN
cord-267897-w4pbq2lb	299	18	models	model	NNS
cord-267897-w4pbq2lb	299	19	against	against	IN
cord-267897-w4pbq2lb	299	20	schistosomiasis	schistosomiasis	NN
cord-267897-w4pbq2lb	299	21	infections	infection	NNS
cord-267897-w4pbq2lb	299	22	.	.	.
cord-267897-w4pbq2lb	300	1	100,101	100,101	CD
cord-267897-w4pbq2lb	300	2	Aluminum	aluminum	NN
cord-267897-w4pbq2lb	300	3	is	be	VBZ
cord-267897-w4pbq2lb	300	4	normally	normally	RB
cord-267897-w4pbq2lb	300	5	found	find	VBN
cord-267897-w4pbq2lb	300	6	in	in	IN
cord-267897-w4pbq2lb	300	7	the	the	DT
cord-267897-w4pbq2lb	300	8	blood	blood	NN
cord-267897-w4pbq2lb	300	9	and	and	CC
cord-267897-w4pbq2lb	300	10	serum	serum	NN
cord-267897-w4pbq2lb	300	11	of	of	IN
cord-267897-w4pbq2lb	300	12	humans	human	NNS
cord-267897-w4pbq2lb	300	13	and	and	CC
cord-267897-w4pbq2lb	300	14	animals	animal	NNS
cord-267897-w4pbq2lb	300	15	whether	whether	IN
cord-267897-w4pbq2lb	300	16	or	or	CC
cord-267897-w4pbq2lb	300	17	not	not	RB
cord-267897-w4pbq2lb	300	18	they	-PRON-	PRP
cord-267897-w4pbq2lb	300	19	have	have	VBP
cord-267897-w4pbq2lb	300	20	been	be	VBN
cord-267897-w4pbq2lb	300	21	vaccinated	vaccinate	VBN
cord-267897-w4pbq2lb	300	22	using	use	VBG
cord-267897-w4pbq2lb	300	23	aluminum	aluminum	NN
cord-267897-w4pbq2lb	300	24	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	300	25	.	.	.
cord-267897-w4pbq2lb	301	1	The	the	DT
cord-267897-w4pbq2lb	301	2	major	major	JJ
cord-267897-w4pbq2lb	301	3	source	source	NN
cord-267897-w4pbq2lb	301	4	of	of	IN
cord-267897-w4pbq2lb	301	5	this	this	DT
cord-267897-w4pbq2lb	301	6	aluminum	aluminum	NN
cord-267897-w4pbq2lb	301	7	is	be	VBZ
cord-267897-w4pbq2lb	301	8	apparently	apparently	RB
cord-267897-w4pbq2lb	301	9	oral	oral	JJ
cord-267897-w4pbq2lb	301	10	intake	intake	NN
cord-267897-w4pbq2lb	301	11	with	with	IN
cord-267897-w4pbq2lb	301	12	the	the	DT
cord-267897-w4pbq2lb	301	13	food	food	NN
cord-267897-w4pbq2lb	301	14	and	and	CC
cord-267897-w4pbq2lb	301	15	drinking	drinking	NN
cord-267897-w4pbq2lb	301	16	water	water	NN
cord-267897-w4pbq2lb	301	17	.	.	.
cord-267897-w4pbq2lb	302	1	Persons	person	NNS
cord-267897-w4pbq2lb	302	2	with	with	IN
cord-267897-w4pbq2lb	302	3	normal	normal	JJ
cord-267897-w4pbq2lb	302	4	kidney	kidney	NN
cord-267897-w4pbq2lb	302	5	function	function	NN
cord-267897-w4pbq2lb	302	6	are	be	VBP
cord-267897-w4pbq2lb	302	7	known	know	VBN
cord-267897-w4pbq2lb	302	8	to	to	TO
cord-267897-w4pbq2lb	302	9	excrete	excrete	VB
cord-267897-w4pbq2lb	302	10	aluminum	aluminum	NN
cord-267897-w4pbq2lb	302	11	with	with	IN
cord-267897-w4pbq2lb	302	12	the	the	DT
cord-267897-w4pbq2lb	302	13	urine	urine	NN
cord-267897-w4pbq2lb	302	14	,	,	,
cord-267897-w4pbq2lb	302	15	whereas	whereas	IN
cord-267897-w4pbq2lb	302	16	persons	person	NNS
cord-267897-w4pbq2lb	302	17	with	with	IN
cord-267897-w4pbq2lb	302	18	impaired	impaired	JJ
cord-267897-w4pbq2lb	302	19	renal	renal	JJ
cord-267897-w4pbq2lb	302	20	function	function	NN
cord-267897-w4pbq2lb	302	21	may	may	MD
cord-267897-w4pbq2lb	302	22	to	to	IN
cord-267897-w4pbq2lb	302	23	some	some	DT
cord-267897-w4pbq2lb	302	24	extent	extent	NN
cord-267897-w4pbq2lb	302	25	accumulate	accumulate	VB
cord-267897-w4pbq2lb	302	26	it	-PRON-	PRP
cord-267897-w4pbq2lb	302	27	and	and	CC
cord-267897-w4pbq2lb	302	28	may	may	MD
cord-267897-w4pbq2lb	302	29	over	over	IN
cord-267897-w4pbq2lb	302	30	a	a	DT
cord-267897-w4pbq2lb	302	31	life	life	NN
cord-267897-w4pbq2lb	302	32	-	-	HYPH
cord-267897-w4pbq2lb	302	33	long	long	JJ
cord-267897-w4pbq2lb	302	34	exposure	exposure	NN
cord-267897-w4pbq2lb	302	35	reach	reach	VBP
cord-267897-w4pbq2lb	302	36	Al	Al	NNP
cord-267897-w4pbq2lb	302	37	levels	level	NNS
cord-267897-w4pbq2lb	302	38	associated	associate	VBN
cord-267897-w4pbq2lb	302	39	with	with	IN
cord-267897-w4pbq2lb	302	40	systemic	systemic	JJ
cord-267897-w4pbq2lb	302	41	adverse	adverse	JJ
cord-267897-w4pbq2lb	302	42	reactions	reaction	NNS
cord-267897-w4pbq2lb	302	43	.	.	.
cord-267897-w4pbq2lb	303	1	The	the	DT
cord-267897-w4pbq2lb	303	2	exposure	exposure	NN
cord-267897-w4pbq2lb	303	3	to	to	TO
cord-267897-w4pbq2lb	303	4	aluminum	aluminum	NN
cord-267897-w4pbq2lb	303	5	from	from	IN
cord-267897-w4pbq2lb	303	6	vaccination	vaccination	NN
cord-267897-w4pbq2lb	303	7	,	,	,
cord-267897-w4pbq2lb	303	8	seen	see	VBN
cord-267897-w4pbq2lb	303	9	over	over	IN
cord-267897-w4pbq2lb	303	10	a	a	DT
cord-267897-w4pbq2lb	303	11	lifetime	lifetime	NN
cord-267897-w4pbq2lb	303	12	,	,	,
cord-267897-w4pbq2lb	303	13	is	be	VBZ
cord-267897-w4pbq2lb	303	14	minimal	minimal	JJ
cord-267897-w4pbq2lb	303	15	compared	compare	VBN
cord-267897-w4pbq2lb	303	16	with	with	IN
cord-267897-w4pbq2lb	303	17	the	the	DT
cord-267897-w4pbq2lb	303	18	daily	daily	JJ
cord-267897-w4pbq2lb	303	19	intake	intake	NN
cord-267897-w4pbq2lb	303	20	of	of	IN
cord-267897-w4pbq2lb	303	21	aluminum	aluminum	NN
cord-267897-w4pbq2lb	303	22	by	by	IN
cord-267897-w4pbq2lb	303	23	drinking	drink	VBG
cord-267897-w4pbq2lb	303	24	water	water	NN
cord-267897-w4pbq2lb	303	25	,	,	,
cord-267897-w4pbq2lb	303	26	antiperspirants	antiperspirant	NNS
cord-267897-w4pbq2lb	303	27	,	,	,
cord-267897-w4pbq2lb	303	28	and	and	CC
cord-267897-w4pbq2lb	303	29	food	food	NN
cord-267897-w4pbq2lb	303	30	additives	additive	NNS
cord-267897-w4pbq2lb	303	31	in	in	IN
cord-267897-w4pbq2lb	303	32	convenience	convenience	NN
cord-267897-w4pbq2lb	303	33	food	food	NN
cord-267897-w4pbq2lb	303	34	.	.	.
cord-267897-w4pbq2lb	304	1	For	for	IN
cord-267897-w4pbq2lb	304	2	example	example	NN
cord-267897-w4pbq2lb	304	3	,	,	,
cord-267897-w4pbq2lb	304	4	bread	bread	NN
cord-267897-w4pbq2lb	304	5	made	make	VBN
cord-267897-w4pbq2lb	304	6	with	with	IN
cord-267897-w4pbq2lb	304	7	aluminum	aluminum	NN
cord-267897-w4pbq2lb	304	8	-	-	HYPH
cord-267897-w4pbq2lb	304	9	based	base	VBN
cord-267897-w4pbq2lb	304	10	baking	baking	NN
cord-267897-w4pbq2lb	304	11	powder	powder	NN
cord-267897-w4pbq2lb	304	12	may	may	MD
cord-267897-w4pbq2lb	304	13	contain	contain	VB
cord-267897-w4pbq2lb	304	14	up	up	IN
cord-267897-w4pbq2lb	304	15	to	to	TO
cord-267897-w4pbq2lb	304	16	15	15	CD
cord-267897-w4pbq2lb	304	17	mg	mg	NN
cord-267897-w4pbq2lb	304	18	aluminum	aluminum	NN
cord-267897-w4pbq2lb	304	19	per	per	IN
cord-267897-w4pbq2lb	304	20	slice	slice	NN
cord-267897-w4pbq2lb	304	21	,	,	,
cord-267897-w4pbq2lb	304	22	and	and	CC
cord-267897-w4pbq2lb	304	23	processed	process	VBN
cord-267897-w4pbq2lb	304	24	American	american	JJ
cord-267897-w4pbq2lb	304	25	cheese	cheese	NN
cord-267897-w4pbq2lb	304	26	contains	contain	VBZ
cord-267897-w4pbq2lb	304	27	as	as	RB
cord-267897-w4pbq2lb	304	28	much	much	JJ
cord-267897-w4pbq2lb	304	29	as	as	IN
cord-267897-w4pbq2lb	304	30	50	50	CD
cord-267897-w4pbq2lb	304	31	mg	mg	NN
cord-267897-w4pbq2lb	304	32	aluminum	aluminum	NN
cord-267897-w4pbq2lb	304	33	per	per	IN
cord-267897-w4pbq2lb	304	34	slice	slice	NN
cord-267897-w4pbq2lb	304	35	.	.	.
cord-267897-w4pbq2lb	305	1	102	102	CD
cord-267897-w4pbq2lb	306	1	Even	even	RB
cord-267897-w4pbq2lb	306	2	if	if	IN
cord-267897-w4pbq2lb	306	3	it	-PRON-	PRP
cord-267897-w4pbq2lb	306	4	is	be	VBZ
cord-267897-w4pbq2lb	306	5	taken	take	VBN
cord-267897-w4pbq2lb	306	6	into	into	IN
cord-267897-w4pbq2lb	306	7	consideration	consideration	NN
cord-267897-w4pbq2lb	306	8	that	that	IN
cord-267897-w4pbq2lb	306	9	only	only	RB
cord-267897-w4pbq2lb	306	10	as	as	RB
cord-267897-w4pbq2lb	306	11	little	little	JJ
cord-267897-w4pbq2lb	306	12	as	as	IN
cord-267897-w4pbq2lb	306	13	0.25	0.25	CD
cord-267897-w4pbq2lb	306	14	%	%	NN
cord-267897-w4pbq2lb	306	15	of	of	IN
cord-267897-w4pbq2lb	306	16	the	the	DT
cord-267897-w4pbq2lb	306	17	ingested	ingest	VBN
cord-267897-w4pbq2lb	306	18	aluminum	aluminum	NN
cord-267897-w4pbq2lb	306	19	may	may	MD
cord-267897-w4pbq2lb	306	20	be	be	VB
cord-267897-w4pbq2lb	306	21	taken	take	VBN
cord-267897-w4pbq2lb	306	22	up	up	RP
cord-267897-w4pbq2lb	306	23	from	from	IN
cord-267897-w4pbq2lb	306	24	the	the	DT
cord-267897-w4pbq2lb	306	25	gastrointestinal	gastrointestinal	JJ
cord-267897-w4pbq2lb	306	26	tract	tract	NN
cord-267897-w4pbq2lb	306	27	,	,	,
cord-267897-w4pbq2lb	306	28	103	103	CD
cord-267897-w4pbq2lb	306	29	exposure	exposure	NN
cord-267897-w4pbq2lb	306	30	to	to	TO
cord-267897-w4pbq2lb	306	31	aluminum	aluminum	NN
cord-267897-w4pbq2lb	306	32	from	from	IN
cord-267897-w4pbq2lb	306	33	the	the	DT
cord-267897-w4pbq2lb	306	34	use	use	NN
cord-267897-w4pbq2lb	306	35	of	of	IN
cord-267897-w4pbq2lb	306	36	adsorbed	adsorbed	JJ
cord-267897-w4pbq2lb	306	37	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	306	38	in	in	IN
cord-267897-w4pbq2lb	306	39	normal	normal	JJ
cord-267897-w4pbq2lb	306	40	vaccination	vaccination	NN
cord-267897-w4pbq2lb	306	41	schedules	schedule	NNS
cord-267897-w4pbq2lb	306	42	will	will	MD
cord-267897-w4pbq2lb	306	43	still	still	RB
cord-267897-w4pbq2lb	306	44	be	be	VB
cord-267897-w4pbq2lb	306	45	minimal	minimal	JJ
cord-267897-w4pbq2lb	306	46	in	in	IN
cord-267897-w4pbq2lb	306	47	comparison	comparison	NN
cord-267897-w4pbq2lb	306	48	.	.	.
cord-267897-w4pbq2lb	307	1	Martyn	Martyn	NNP
cord-267897-w4pbq2lb	307	2	and	and	CC
cord-267897-w4pbq2lb	307	3	coworkers	coworker	NNS
cord-267897-w4pbq2lb	307	4	,	,	,
cord-267897-w4pbq2lb	307	5	104	104	CD
cord-267897-w4pbq2lb	307	6	based	base	VBN
cord-267897-w4pbq2lb	307	7	on	on	IN
cord-267897-w4pbq2lb	307	8	a	a	DT
cord-267897-w4pbq2lb	307	9	study	study	NN
cord-267897-w4pbq2lb	307	10	in	in	IN
cord-267897-w4pbq2lb	307	11	Britain	Britain	NNP
cord-267897-w4pbq2lb	307	12	,	,	,
cord-267897-w4pbq2lb	307	13	reported	report	VBD
cord-267897-w4pbq2lb	307	14	the	the	DT
cord-267897-w4pbq2lb	307	15	average	average	JJ
cord-267897-w4pbq2lb	307	16	daily	daily	JJ
cord-267897-w4pbq2lb	307	17	intake	intake	NN
cord-267897-w4pbq2lb	307	18	of	of	IN
cord-267897-w4pbq2lb	307	19	aluminum	aluminum	NN
cord-267897-w4pbq2lb	307	20	by	by	IN
cord-267897-w4pbq2lb	307	21	humans	human	NNS
cord-267897-w4pbq2lb	307	22	from	from	IN
cord-267897-w4pbq2lb	307	23	drinking	drink	VBG
cord-267897-w4pbq2lb	307	24	water	water	NN
cord-267897-w4pbq2lb	307	25	to	to	TO
cord-267897-w4pbq2lb	307	26	be	be	VB
cord-267897-w4pbq2lb	307	27	5e10	5e10	CD
cord-267897-w4pbq2lb	307	28	mg	mg	NN
cord-267897-w4pbq2lb	307	29	.	.	.
cord-267897-w4pbq2lb	308	1	A	a	DT
cord-267897-w4pbq2lb	308	2	major	major	JJ
cord-267897-w4pbq2lb	308	3	difference	difference	NN
cord-267897-w4pbq2lb	308	4	between	between	IN
cord-267897-w4pbq2lb	308	5	aluminum	aluminum	NN
cord-267897-w4pbq2lb	308	6	-	-	HYPH
cord-267897-w4pbq2lb	308	7	and	and	CC
cord-267897-w4pbq2lb	308	8	calcium	calcium	NN
cord-267897-w4pbq2lb	308	9	-	-	HYPH
cord-267897-w4pbq2lb	308	10	based	base	VBN
cord-267897-w4pbq2lb	308	11	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	308	12	lies	lie	VBZ
cord-267897-w4pbq2lb	308	13	in	in	IN
cord-267897-w4pbq2lb	308	14	the	the	DT
cord-267897-w4pbq2lb	308	15	in	in	IN
cord-267897-w4pbq2lb	308	16	vivo	vivo	NN
cord-267897-w4pbq2lb	308	17	clearing	clearing	NN
cord-267897-w4pbq2lb	308	18	of	of	IN
cord-267897-w4pbq2lb	308	19	the	the	DT
cord-267897-w4pbq2lb	308	20	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	308	21	inoculum	inoculum	NN
cord-267897-w4pbq2lb	308	22	and	and	CC
cord-267897-w4pbq2lb	308	23	the	the	DT
cord-267897-w4pbq2lb	308	24	metabolic	metabolic	JJ
cord-267897-w4pbq2lb	308	25	fate	fate	NN
cord-267897-w4pbq2lb	308	26	of	of	IN
cord-267897-w4pbq2lb	308	27	the	the	DT
cord-267897-w4pbq2lb	308	28	degradation	degradation	NN
cord-267897-w4pbq2lb	308	29	products	product	NNS
cord-267897-w4pbq2lb	308	30	.	.	.
cord-267897-w4pbq2lb	309	1	Upon	upon	IN
cord-267897-w4pbq2lb	309	2	degradation	degradation	NN
cord-267897-w4pbq2lb	309	3	of	of	IN
cord-267897-w4pbq2lb	309	4	calcium	calcium	NN
cord-267897-w4pbq2lb	309	5	phosphate	phosphate	NN
cord-267897-w4pbq2lb	309	6	,	,	,
cord-267897-w4pbq2lb	309	7	the	the	DT
cord-267897-w4pbq2lb	309	8	two	two	CD
cord-267897-w4pbq2lb	309	9	constituents	constituent	NNS
cord-267897-w4pbq2lb	309	10	can	can	MD
cord-267897-w4pbq2lb	309	11	be	be	VB
cord-267897-w4pbq2lb	309	12	reutilized	reutilize	VBN
cord-267897-w4pbq2lb	309	13	in	in	IN
cord-267897-w4pbq2lb	309	14	the	the	DT
cord-267897-w4pbq2lb	309	15	normal	normal	JJ
cord-267897-w4pbq2lb	309	16	physiological	physiological	JJ
cord-267897-w4pbq2lb	309	17	pathways	pathway	NNS
cord-267897-w4pbq2lb	309	18	for	for	IN
cord-267897-w4pbq2lb	309	19	Ca	Ca	NNP
cord-267897-w4pbq2lb	309	20	þþ	þþ	NNP
cord-267897-w4pbq2lb	309	21	and	and	CC
cord-267897-w4pbq2lb	309	22	PO	PO	NNP
cord-267897-w4pbq2lb	309	23	À	À	NNP
cord-267897-w4pbq2lb	309	24	4	4	CD
cord-267897-w4pbq2lb	309	25	respectively	respectively	RB
cord-267897-w4pbq2lb	309	26	,	,	,
cord-267897-w4pbq2lb	309	27	whereas	whereas	IN
cord-267897-w4pbq2lb	309	28	in	in	IN
cord-267897-w4pbq2lb	309	29	contrast	contrast	NN
cord-267897-w4pbq2lb	309	30	to	to	IN
cord-267897-w4pbq2lb	309	31	other	other	JJ
cord-267897-w4pbq2lb	309	32	metallic	metallic	JJ
cord-267897-w4pbq2lb	309	33	ions	ion	NNS
cord-267897-w4pbq2lb	309	34	,	,	,
cord-267897-w4pbq2lb	310	1	like	like	IN
cord-267897-w4pbq2lb	310	2	Zn	Zn	NNP
cord-267897-w4pbq2lb	310	3	þþ	þþ	NNP
cord-267897-w4pbq2lb	310	4	and	and	CC
cord-267897-w4pbq2lb	310	5	Mg	Mg	NNP
cord-267897-w4pbq2lb	310	6	þþ	þþ	IN
cord-267897-w4pbq2lb	310	7	,	,	,
cord-267897-w4pbq2lb	310	8	aluminum	aluminum	NN
cord-267897-w4pbq2lb	310	9	apparently	apparently	RB
cord-267897-w4pbq2lb	310	10	does	do	VBZ
cord-267897-w4pbq2lb	310	11	not	not	RB
cord-267897-w4pbq2lb	310	12	act	act	VB
cord-267897-w4pbq2lb	310	13	as	as	IN
cord-267897-w4pbq2lb	310	14	essential	essential	JJ
cord-267897-w4pbq2lb	310	15	trace	trace	NN
cord-267897-w4pbq2lb	310	16	element	element	NN
cord-267897-w4pbq2lb	310	17	or	or	CC
cord-267897-w4pbq2lb	310	18	coenzyme	coenzyme	NN
cord-267897-w4pbq2lb	310	19	in	in	IN
cord-267897-w4pbq2lb	310	20	the	the	DT
cord-267897-w4pbq2lb	310	21	normal	normal	JJ
cord-267897-w4pbq2lb	310	22	metabolism	metabolism	NN
cord-267897-w4pbq2lb	310	23	.	.	.
cord-267897-w4pbq2lb	311	1	However	however	RB
cord-267897-w4pbq2lb	311	2	,	,	,
cord-267897-w4pbq2lb	311	3	previous	previous	JJ
cord-267897-w4pbq2lb	311	4	claims	claim	NNS
cord-267897-w4pbq2lb	311	5	that	that	IN
cord-267897-w4pbq2lb	311	6	aluminum	aluminum	NN
cord-267897-w4pbq2lb	311	7	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	311	8	are	be	VBP
cord-267897-w4pbq2lb	311	9	not	not	RB
cord-267897-w4pbq2lb	311	10	broken	break	VBN
cord-267897-w4pbq2lb	311	11	down	down	RP
cord-267897-w4pbq2lb	311	12	in	in	IN
cord-267897-w4pbq2lb	311	13	situ	situ	NN
cord-267897-w4pbq2lb	311	14	and	and	CC
cord-267897-w4pbq2lb	311	15	excreted	excrete	VBN
cord-267897-w4pbq2lb	311	16	have	have	VBP
cord-267897-w4pbq2lb	311	17	been	be	VBN
cord-267897-w4pbq2lb	311	18	shown	show	VBN
cord-267897-w4pbq2lb	311	19	to	to	TO
cord-267897-w4pbq2lb	311	20	be	be	VB
cord-267897-w4pbq2lb	311	21	incorrect	incorrect	JJ
cord-267897-w4pbq2lb	311	22	.	.	.
cord-267897-w4pbq2lb	312	1	The	the	DT
cord-267897-w4pbq2lb	312	2	in	in	IN
cord-267897-w4pbq2lb	312	3	vivo	vivo	NN
cord-267897-w4pbq2lb	312	4	clearing	clearing	NN
cord-267897-w4pbq2lb	312	5	of	of	IN
cord-267897-w4pbq2lb	312	6	parentally	parentally	RB
cord-267897-w4pbq2lb	312	7	administered	administer	VBN
cord-267897-w4pbq2lb	312	8	aluminum	aluminum	NN
cord-267897-w4pbq2lb	312	9	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	312	10	has	have	VBZ
cord-267897-w4pbq2lb	312	11	been	be	VBN
cord-267897-w4pbq2lb	312	12	investigated	investigate	VBN
cord-267897-w4pbq2lb	312	13	in	in	IN
cord-267897-w4pbq2lb	312	14	rabbits	rabbit	NNS
cord-267897-w4pbq2lb	312	15	by	by	IN
cord-267897-w4pbq2lb	312	16	Flarend	Flarend	NNP
cord-267897-w4pbq2lb	312	17	et	et	NNP
cord-267897-w4pbq2lb	312	18	al	al	NNP
cord-267897-w4pbq2lb	312	19	.	.	.
cord-267897-w4pbq2lb	313	1	using	use	VBG
cord-267897-w4pbq2lb	313	2	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	313	3	prepared	prepare	VBN
cord-267897-w4pbq2lb	313	4	from	from	IN
cord-267897-w4pbq2lb	313	5	the	the	DT
cord-267897-w4pbq2lb	313	6	isotope	isotope	NN
cord-267897-w4pbq2lb	313	7	26	26	CD
cord-267897-w4pbq2lb	313	8	Al	Al	NNP
cord-267897-w4pbq2lb	313	9	.	.	.
cord-267897-w4pbq2lb	314	1	105	105	CD
cord-267897-w4pbq2lb	314	2	Blood	blood	NN
cord-267897-w4pbq2lb	314	3	-	-	HYPH
cord-267897-w4pbq2lb	314	4	and	and	CC
cord-267897-w4pbq2lb	314	5	urine	urine	NN
cord-267897-w4pbq2lb	314	6	-	-	HYPH
cord-267897-w4pbq2lb	314	7	excreted	excrete	VBN
cord-267897-w4pbq2lb	314	8	26	26	CD
cord-267897-w4pbq2lb	314	9	Al	Al	NNP
cord-267897-w4pbq2lb	314	10	was	be	VBD
cord-267897-w4pbq2lb	314	11	followed	follow	VBN
cord-267897-w4pbq2lb	314	12	using	use	VBG
cord-267897-w4pbq2lb	314	13	accelerator	accelerator	NN
cord-267897-w4pbq2lb	314	14	mass	mass	NN
cord-267897-w4pbq2lb	314	15	spectroscopy	spectroscopy	NN
cord-267897-w4pbq2lb	314	16	for	for	IN
cord-267897-w4pbq2lb	314	17	a	a	DT
cord-267897-w4pbq2lb	314	18	period	period	NN
cord-267897-w4pbq2lb	314	19	of	of	IN
cord-267897-w4pbq2lb	314	20	28	28	CD
cord-267897-w4pbq2lb	314	21	days	day	NNS
cord-267897-w4pbq2lb	314	22	.	.	.
cord-267897-w4pbq2lb	315	1	As	as	RB
cord-267897-w4pbq2lb	315	2	early	early	RB
cord-267897-w4pbq2lb	315	3	as	as	IN
cord-267897-w4pbq2lb	315	4	1	1	CD
cord-267897-w4pbq2lb	315	5	h	h	NN
cord-267897-w4pbq2lb	315	6	following	follow	VBG
cord-267897-w4pbq2lb	315	7	intramuscular	intramuscular	JJ
cord-267897-w4pbq2lb	315	8	(	(	-LRB-
cord-267897-w4pbq2lb	315	9	IM	im	NN
cord-267897-w4pbq2lb	315	10	)	)	-RRB-
cord-267897-w4pbq2lb	315	11	injection	injection	NN
cord-267897-w4pbq2lb	315	12	,	,	,
cord-267897-w4pbq2lb	315	13	radioactive	radioactive	JJ
cord-267897-w4pbq2lb	315	14	labeled	label	VBN
cord-267897-w4pbq2lb	315	15	Al	Al	NNP
cord-267897-w4pbq2lb	315	16	could	could	MD
cord-267897-w4pbq2lb	315	17	be	be	VB
cord-267897-w4pbq2lb	315	18	detected	detect	VBN
cord-267897-w4pbq2lb	315	19	in	in	IN
cord-267897-w4pbq2lb	315	20	the	the	DT
cord-267897-w4pbq2lb	315	21	blood	blood	NN
cord-267897-w4pbq2lb	315	22	and	and	CC
cord-267897-w4pbq2lb	315	23	it	-PRON-	PRP
cord-267897-w4pbq2lb	315	24	was	be	VBD
cord-267897-w4pbq2lb	315	25	found	find	VBN
cord-267897-w4pbq2lb	315	26	that	that	IN
cord-267897-w4pbq2lb	315	27	approximately	approximately	RB
cord-267897-w4pbq2lb	315	28	three	three	CD
cord-267897-w4pbq2lb	315	29	times	time	NNS
cord-267897-w4pbq2lb	315	30	more	more	JJR
cord-267897-w4pbq2lb	315	31	26	26	CD
cord-267897-w4pbq2lb	316	1	Al	Al	NNP
cord-267897-w4pbq2lb	316	2	was	be	VBD
cord-267897-w4pbq2lb	316	3	excreted	excrete	VBN
cord-267897-w4pbq2lb	316	4	from	from	IN
cord-267897-w4pbq2lb	316	5	animals	animal	NNS
cord-267897-w4pbq2lb	316	6	vaccinated	vaccinate	VBN
cord-267897-w4pbq2lb	316	7	with	with	IN
cord-267897-w4pbq2lb	316	8	aluminum	aluminum	NN
cord-267897-w4pbq2lb	316	9	phosphate	phosphate	NN
cord-267897-w4pbq2lb	316	10	than	than	IN
cord-267897-w4pbq2lb	316	11	those	those	DT
cord-267897-w4pbq2lb	316	12	vaccinated	vaccinate	VBN
cord-267897-w4pbq2lb	316	13	with	with	IN
cord-267897-w4pbq2lb	316	14	aluminum	aluminum	NN
cord-267897-w4pbq2lb	316	15	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	316	16	.	.	.
cord-267897-w4pbq2lb	317	1	Assumingly	assumingly	RB
cord-267897-w4pbq2lb	317	2	,	,	,
cord-267897-w4pbq2lb	317	3	interstitial	interstitial	JJ
cord-267897-w4pbq2lb	317	4	fluid	fluid	NN
cord-267897-w4pbq2lb	317	5	containing	contain	VBG
cord-267897-w4pbq2lb	317	6	organic	organic	JJ
cord-267897-w4pbq2lb	317	7	acids	acid	NNS
cord-267897-w4pbq2lb	317	8	with	with	IN
cord-267897-w4pbq2lb	317	9	an	an	DT
cord-267897-w4pbq2lb	317	10	a	a	DT
cord-267897-w4pbq2lb	317	11	-	-	HYPH
cord-267897-w4pbq2lb	317	12	hydroxy	hydroxy	JJ
cord-267897-w4pbq2lb	317	13	carboxylic	carboxylic	JJ
cord-267897-w4pbq2lb	317	14	acid	acid	NN
cord-267897-w4pbq2lb	317	15	,	,	,
cord-267897-w4pbq2lb	317	16	able	able	JJ
cord-267897-w4pbq2lb	317	17	to	to	TO
cord-267897-w4pbq2lb	317	18	chelate	chelate	VB
cord-267897-w4pbq2lb	317	19	Al	Al	NNP
cord-267897-w4pbq2lb	317	20	,	,	,
cord-267897-w4pbq2lb	317	21	reacted	react	VBD
cord-267897-w4pbq2lb	317	22	more	more	RBR
cord-267897-w4pbq2lb	317	23	readily	readily	RB
cord-267897-w4pbq2lb	317	24	with	with	IN
cord-267897-w4pbq2lb	317	25	aluminum	aluminum	NN
cord-267897-w4pbq2lb	317	26	phosphate	phosphate	NN
cord-267897-w4pbq2lb	317	27	than	than	IN
cord-267897-w4pbq2lb	317	28	with	with	IN
cord-267897-w4pbq2lb	317	29	aluminum	aluminum	NN
cord-267897-w4pbq2lb	317	30	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	317	31	.	.	.
cord-267897-w4pbq2lb	318	1	105	105	CD
cord-267897-w4pbq2lb	319	1	At	at	IN
cord-267897-w4pbq2lb	319	2	day	day	NN
cord-267897-w4pbq2lb	319	3	28	28	CD
cord-267897-w4pbq2lb	319	4	,	,	,
cord-267897-w4pbq2lb	319	5	the	the	DT
cord-267897-w4pbq2lb	319	6	rabbits	rabbit	NNS
cord-267897-w4pbq2lb	319	7	were	be	VBD
cord-267897-w4pbq2lb	319	8	euthanized	euthanize	VBN
cord-267897-w4pbq2lb	319	9	,	,	,
cord-267897-w4pbq2lb	319	10	the	the	DT
cord-267897-w4pbq2lb	319	11	main	main	JJ
cord-267897-w4pbq2lb	319	12	organs	organ	NNS
cord-267897-w4pbq2lb	319	13	were	be	VBD
cord-267897-w4pbq2lb	319	14	digested	digest	VBN
cord-267897-w4pbq2lb	319	15	using	use	VBG
cord-267897-w4pbq2lb	319	16	nitric	nitric	JJ
cord-267897-w4pbq2lb	319	17	acid	acid	NN
cord-267897-w4pbq2lb	319	18	,	,	,
cord-267897-w4pbq2lb	319	19	and	and	CC
cord-267897-w4pbq2lb	319	20	the	the	DT
cord-267897-w4pbq2lb	319	21	radioactivity	radioactivity	NN
cord-267897-w4pbq2lb	319	22	measured	measure	VBN
cord-267897-w4pbq2lb	319	23	.	.	.
cord-267897-w4pbq2lb	320	1	The	the	DT
cord-267897-w4pbq2lb	320	2	relative	relative	JJ
cord-267897-w4pbq2lb	320	3	tissue	tissue	NN
cord-267897-w4pbq2lb	320	4	distribution	distribution	NN
cord-267897-w4pbq2lb	320	5	of	of	IN
cord-267897-w4pbq2lb	320	6	radiolabeled	radiolabele	VBN
cord-267897-w4pbq2lb	320	7	Al	Al	NNP
cord-267897-w4pbq2lb	320	8	was	be	VBD
cord-267897-w4pbq2lb	320	9	:	:	:
cord-267897-w4pbq2lb	320	10	kidney	kidney	NN
cord-267897-w4pbq2lb	320	11	>	>	XX
cord-267897-w4pbq2lb	320	12	spleen	spleen	NNS
cord-267897-w4pbq2lb	321	1	>	>	XX
cord-267897-w4pbq2lb	322	1	liver	liver	NN
cord-267897-w4pbq2lb	322	2	>	>	XX
cord-267897-w4pbq2lb	323	1	heart	heart	NN
cord-267897-w4pbq2lb	323	2	>	>	XX
cord-267897-w4pbq2lb	323	3	lymph	lymph	NN
cord-267897-w4pbq2lb	323	4	node	node	NN
cord-267897-w4pbq2lb	324	1	>	>	XX
cord-267897-w4pbq2lb	324	2	brain	brain	NN
cord-267897-w4pbq2lb	324	3	.	.	.
cord-267897-w4pbq2lb	325	1	It	-PRON-	PRP
cord-267897-w4pbq2lb	325	2	is	be	VBZ
cord-267897-w4pbq2lb	325	3	likely	likely	JJ
cord-267897-w4pbq2lb	325	4	that	that	IN
cord-267897-w4pbq2lb	325	5	the	the	DT
cord-267897-w4pbq2lb	325	6	excretion	excretion	NN
cord-267897-w4pbq2lb	325	7	through	through	IN
cord-267897-w4pbq2lb	325	8	blood	blood	NN
cord-267897-w4pbq2lb	325	9	and	and	CC
cord-267897-w4pbq2lb	325	10	urine	urine	NN
cord-267897-w4pbq2lb	325	11	described	describe	VBN
cord-267897-w4pbq2lb	325	12	earlier	early	RBR
cord-267897-w4pbq2lb	325	13	primarily	primarily	RB
cord-267897-w4pbq2lb	325	14	involves	involve	VBZ
cord-267897-w4pbq2lb	325	15	Al	Al	NNP
cord-267897-w4pbq2lb	325	16	dissolved	dissolve	VBD
cord-267897-w4pbq2lb	325	17	under	under	IN
cord-267897-w4pbq2lb	325	18	the	the	DT
cord-267897-w4pbq2lb	325	19	influence	influence	NN
cord-267897-w4pbq2lb	325	20	of	of	IN
cord-267897-w4pbq2lb	325	21	interstitial	interstitial	JJ
cord-267897-w4pbq2lb	325	22	fluid	fluid	NN
cord-267897-w4pbq2lb	325	23	,	,	,
cord-267897-w4pbq2lb	325	24	whereas	whereas	IN
cord-267897-w4pbq2lb	325	25	the	the	DT
cord-267897-w4pbq2lb	325	26	radioactivity	radioactivity	NN
cord-267897-w4pbq2lb	325	27	detected	detect	VBN
cord-267897-w4pbq2lb	325	28	in	in	IN
cord-267897-w4pbq2lb	325	29	lymph	lymph	NN
cord-267897-w4pbq2lb	325	30	nodes	node	NNS
cord-267897-w4pbq2lb	325	31	and	and	CC
cord-267897-w4pbq2lb	325	32	spleen	spleen	NNS
cord-267897-w4pbq2lb	325	33	also	also	RB
cord-267897-w4pbq2lb	325	34	involved	involve	VBD
cord-267897-w4pbq2lb	325	35	Al	Al	NNP
cord-267897-w4pbq2lb	325	36	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	325	37	taken	take	VBN
cord-267897-w4pbq2lb	325	38	up	up	RP
cord-267897-w4pbq2lb	325	39	by	by	IN
cord-267897-w4pbq2lb	325	40	APCs	apc	NNS
cord-267897-w4pbq2lb	325	41	.	.	.
cord-267897-w4pbq2lb	326	1	Following	follow	VBG
cord-267897-w4pbq2lb	326	2	injection	injection	NN
cord-267897-w4pbq2lb	326	3	of	of	IN
cord-267897-w4pbq2lb	326	4	aluminum	aluminum	NN
cord-267897-w4pbq2lb	326	5	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	326	6	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	326	7	containing	contain	VBG
cord-267897-w4pbq2lb	326	8	0.85	0.85	CD
cord-267897-w4pbq2lb	326	9	mg	mg	NNP
cord-267897-w4pbq2lb	327	1	Al	Al	NNP
cord-267897-w4pbq2lb	327	2	the	the	DT
cord-267897-w4pbq2lb	327	3	normal	normal	JJ
cord-267897-w4pbq2lb	327	4	plasma	plasma	NN
cord-267897-w4pbq2lb	327	5	concentration	concentration	NN
cord-267897-w4pbq2lb	327	6	of	of	IN
cord-267897-w4pbq2lb	327	7	30	30	CD
cord-267897-w4pbq2lb	327	8	ng	ng	NNP
cord-267897-w4pbq2lb	327	9	Al	Al	NNP
cord-267897-w4pbq2lb	327	10	/	/	SYM
cord-267897-w4pbq2lb	327	11	mL	mL	NNP
cord-267897-w4pbq2lb	327	12	only	only	RB
cord-267897-w4pbq2lb	327	13	rose	rise	VBD
cord-267897-w4pbq2lb	327	14	by	by	IN
cord-267897-w4pbq2lb	327	15	approximately	approximately	RB
cord-267897-w4pbq2lb	327	16	2	2	CD
cord-267897-w4pbq2lb	327	17	ng	ng	NNP
cord-267897-w4pbq2lb	327	18	Al	Al	NNP
cord-267897-w4pbq2lb	327	19	/	/	SYM
cord-267897-w4pbq2lb	327	20	mL	mL	NNP
cord-267897-w4pbq2lb	327	21	in	in	IN
cord-267897-w4pbq2lb	327	22	Flarend	Flarend	NNP
cord-267897-w4pbq2lb	327	23	's	's	POS
cord-267897-w4pbq2lb	327	24	rabbits	rabbit	NNS
cord-267897-w4pbq2lb	327	25	.	.	.
cord-267897-w4pbq2lb	328	1	According	accord	VBG
cord-267897-w4pbq2lb	328	2	to	to	IN
cord-267897-w4pbq2lb	328	3	the	the	DT
cord-267897-w4pbq2lb	328	4	calculation	calculation	NN
cord-267897-w4pbq2lb	328	5	of	of	IN
cord-267897-w4pbq2lb	328	6	Flarend	Flarend	NNP
cord-267897-w4pbq2lb	328	7	,	,	,
cord-267897-w4pbq2lb	328	8	a	a	DT
cord-267897-w4pbq2lb	328	9	similar	similar	JJ
cord-267897-w4pbq2lb	328	10	Al	Al	NNP
cord-267897-w4pbq2lb	328	11	dose	dose	NN
cord-267897-w4pbq2lb	328	12	injected	inject	VBN
cord-267897-w4pbq2lb	328	13	into	into	IN
cord-267897-w4pbq2lb	328	14	humans	human	NNS
cord-267897-w4pbq2lb	328	15	,	,	,
cord-267897-w4pbq2lb	328	16	provided	provide	VBD
cord-267897-w4pbq2lb	328	17	similar	similar	JJ
cord-267897-w4pbq2lb	328	18	clearing	clearing	NN
cord-267897-w4pbq2lb	328	19	kinetics	kinetics	NNP
cord-267897-w4pbq2lb	328	20	existed	exist	VBD
cord-267897-w4pbq2lb	328	21	,	,	,
cord-267897-w4pbq2lb	328	22	would	would	MD
cord-267897-w4pbq2lb	328	23	lead	lead	VB
cord-267897-w4pbq2lb	328	24	to	to	IN
cord-267897-w4pbq2lb	328	25	an	an	DT
cord-267897-w4pbq2lb	328	26	estimated	estimate	VBN
cord-267897-w4pbq2lb	328	27	increase	increase	NN
cord-267897-w4pbq2lb	328	28	of	of	IN
cord-267897-w4pbq2lb	328	29	serum	serum	NN
cord-267897-w4pbq2lb	328	30	Al	Al	NNP
cord-267897-w4pbq2lb	328	31	of	of	IN
cord-267897-w4pbq2lb	328	32	only	only	RB
cord-267897-w4pbq2lb	328	33	0.04	0.04	CD
cord-267897-w4pbq2lb	328	34	ng	ng	NNP
cord-267897-w4pbq2lb	328	35	Al	Al	NNP
cord-267897-w4pbq2lb	328	36	/	/	SYM
cord-267897-w4pbq2lb	328	37	mL	mL	NNP
cord-267897-w4pbq2lb	328	38	,	,	,
cord-267897-w4pbq2lb	328	39	equaling	equal	VBG
cord-267897-w4pbq2lb	328	40	0.8	0.8	CD
cord-267897-w4pbq2lb	328	41	%	%	NN
cord-267897-w4pbq2lb	328	42	above	above	IN
cord-267897-w4pbq2lb	328	43	the	the	DT
cord-267897-w4pbq2lb	328	44	normal	normal	JJ
cord-267897-w4pbq2lb	328	45	level	level	NN
cord-267897-w4pbq2lb	328	46	of	of	IN
cord-267897-w4pbq2lb	328	47	approximately	approximately	RB
cord-267897-w4pbq2lb	328	48	5	5	CD
cord-267897-w4pbq2lb	328	49	ng	ng	NNP
cord-267897-w4pbq2lb	328	50	Al	Al	NNP
cord-267897-w4pbq2lb	328	51	/	/	SYM
cord-267897-w4pbq2lb	328	52	mL.	mL.	NNP
cord-267897-w4pbq2lb	329	1	As	as	IN
cord-267897-w4pbq2lb	329	2	the	the	DT
cord-267897-w4pbq2lb	329	3	applied	applied	JJ
cord-267897-w4pbq2lb	329	4	dose	dose	NN
cord-267897-w4pbq2lb	329	5	of	of	IN
cord-267897-w4pbq2lb	329	6	0.85	0.85	CD
cord-267897-w4pbq2lb	329	7	mg	mg	NNS
cord-267897-w4pbq2lb	330	1	Al	Al	NNP
cord-267897-w4pbq2lb	330	2	corresponds	correspond	VBZ
cord-267897-w4pbq2lb	330	3	to	to	IN
cord-267897-w4pbq2lb	330	4	what	what	WP
cord-267897-w4pbq2lb	330	5	is	be	VBZ
cord-267897-w4pbq2lb	330	6	normally	normally	RB
cord-267897-w4pbq2lb	330	7	used	use	VBN
cord-267897-w4pbq2lb	330	8	in	in	IN
cord-267897-w4pbq2lb	330	9	human	human	JJ
cord-267897-w4pbq2lb	330	10	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	330	11	,	,	,
cord-267897-w4pbq2lb	330	12	it	-PRON-	PRP
cord-267897-w4pbq2lb	330	13	seems	seem	VBZ
cord-267897-w4pbq2lb	330	14	that	that	IN
cord-267897-w4pbq2lb	330	15	the	the	DT
cord-267897-w4pbq2lb	330	16	amount	amount	NN
cord-267897-w4pbq2lb	330	17	of	of	IN
cord-267897-w4pbq2lb	330	18	aluminum	aluminum	NN
cord-267897-w4pbq2lb	330	19	administered	administer	VBN
cord-267897-w4pbq2lb	330	20	via	via	IN
cord-267897-w4pbq2lb	330	21	vaccination	vaccination	NN
cord-267897-w4pbq2lb	330	22	does	do	VBZ
cord-267897-w4pbq2lb	330	23	not	not	RB
cord-267897-w4pbq2lb	330	24	contribute	contribute	VB
cord-267897-w4pbq2lb	330	25	significantly	significantly	RB
cord-267897-w4pbq2lb	330	26	to	to	IN
cord-267897-w4pbq2lb	330	27	the	the	DT
cord-267897-w4pbq2lb	330	28	normal	normal	JJ
cord-267897-w4pbq2lb	330	29	exposure	exposure	NN
cord-267897-w4pbq2lb	330	30	to	to	TO
cord-267897-w4pbq2lb	330	31	aluminum	aluminum	NN
cord-267897-w4pbq2lb	330	32	in	in	IN
cord-267897-w4pbq2lb	330	33	humans	human	NNS
cord-267897-w4pbq2lb	330	34	and	and	CC
cord-267897-w4pbq2lb	330	35	serum	serum	NN
cord-267897-w4pbq2lb	330	36	levels	level	NNS
cord-267897-w4pbq2lb	330	37	of	of	IN
cord-267897-w4pbq2lb	330	38	aluminum	aluminum	NN
cord-267897-w4pbq2lb	330	39	.	.	.
cord-267897-w4pbq2lb	331	1	Aluminum	aluminum	NN
cord-267897-w4pbq2lb	331	2	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	331	3	and	and	CC
cord-267897-w4pbq2lb	331	4	aluminum	aluminum	NN
cord-267897-w4pbq2lb	331	5	phosphate	phosphate	NN
cord-267897-w4pbq2lb	331	6	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	331	7	have	have	VBP
cord-267897-w4pbq2lb	331	8	been	be	VBN
cord-267897-w4pbq2lb	331	9	used	use	VBN
cord-267897-w4pbq2lb	331	10	for	for	IN
cord-267897-w4pbq2lb	331	11	more	more	JJR
cord-267897-w4pbq2lb	331	12	than	than	IN
cord-267897-w4pbq2lb	331	13	half	half	PDT
cord-267897-w4pbq2lb	331	14	a	a	DT
cord-267897-w4pbq2lb	331	15	century	century	NN
cord-267897-w4pbq2lb	331	16	now	now	RB
cord-267897-w4pbq2lb	331	17	and	and	CC
cord-267897-w4pbq2lb	331	18	are	be	VBP
cord-267897-w4pbq2lb	331	19	generally	generally	RB
cord-267897-w4pbq2lb	331	20	regarded	regard	VBN
cord-267897-w4pbq2lb	331	21	as	as	RB
cord-267897-w4pbq2lb	331	22	safe	safe	JJ
cord-267897-w4pbq2lb	331	23	when	when	WRB
cord-267897-w4pbq2lb	331	24	used	use	VBN
cord-267897-w4pbq2lb	331	25	according	accord	VBG
cord-267897-w4pbq2lb	331	26	to	to	IN
cord-267897-w4pbq2lb	331	27	the	the	DT
cord-267897-w4pbq2lb	331	28	current	current	JJ
cord-267897-w4pbq2lb	331	29	immunization	immunization	NN
cord-267897-w4pbq2lb	331	30	schedules	schedule	NNS
cord-267897-w4pbq2lb	331	31	.	.	.
cord-267897-w4pbq2lb	332	1	2	2	LS
cord-267897-w4pbq2lb	333	1	In	in	IN
cord-267897-w4pbq2lb	333	2	1993	1993	CD
cord-267897-w4pbq2lb	333	3	,	,	,
cord-267897-w4pbq2lb	333	4	the	the	DT
cord-267897-w4pbq2lb	333	5	US	US	NNP
cord-267897-w4pbq2lb	333	6	NCVDG	NCVDG	NNP
cord-267897-w4pbq2lb	333	7	Working	Working	NNP
cord-267897-w4pbq2lb	333	8	Group	Group	NNP
cord-267897-w4pbq2lb	333	9	on	on	IN
cord-267897-w4pbq2lb	333	10	Safety	Safety	NNP
cord-267897-w4pbq2lb	333	11	Evaluation	Evaluation	NNP
cord-267897-w4pbq2lb	333	12	of	of	IN
cord-267897-w4pbq2lb	333	13	Vaccine	Vaccine	NNP
cord-267897-w4pbq2lb	333	14	Adjuvants	Adjuvants	NNP
cord-267897-w4pbq2lb	333	15	with	with	IN
cord-267897-w4pbq2lb	333	16	the	the	DT
cord-267897-w4pbq2lb	333	17	participation	participation	NN
cord-267897-w4pbq2lb	333	18	of	of	IN
cord-267897-w4pbq2lb	333	19	the	the	DT
cord-267897-w4pbq2lb	333	20	US	US	NNP
cord-267897-w4pbq2lb	333	21	Food	Food	NNP
cord-267897-w4pbq2lb	333	22	and	and	CC
cord-267897-w4pbq2lb	333	23	Drug	Drug	NNP
cord-267897-w4pbq2lb	333	24	Administration	Administration	NNP
cord-267897-w4pbq2lb	333	25	representatives	representative	NNS
cord-267897-w4pbq2lb	333	26	concluded	conclude	VBD
cord-267897-w4pbq2lb	333	27	that	that	IN
cord-267897-w4pbq2lb	333	28	"	"	``
cord-267897-w4pbq2lb	333	29	the	the	DT
cord-267897-w4pbq2lb	333	30	extensive	extensive	JJ
cord-267897-w4pbq2lb	333	31	experience	experience	NN
cord-267897-w4pbq2lb	333	32	with	with	IN
cord-267897-w4pbq2lb	333	33	this	this	DT
cord-267897-w4pbq2lb	333	34	class	class	NN
cord-267897-w4pbq2lb	333	35	of	of	IN
cord-267897-w4pbq2lb	333	36	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	333	37	for	for	IN
cord-267897-w4pbq2lb	333	38	vaccine	vaccine	NN
cord-267897-w4pbq2lb	333	39	use	use	NN
cord-267897-w4pbq2lb	333	40	has	have	VBZ
cord-267897-w4pbq2lb	333	41	indicated	indicate	VBN
cord-267897-w4pbq2lb	333	42	that	that	IN
cord-267897-w4pbq2lb	333	43	it	-PRON-	PRP
cord-267897-w4pbq2lb	333	44	is	be	VBZ
cord-267897-w4pbq2lb	333	45	safe	safe	JJ
cord-267897-w4pbq2lb	333	46	.	.	.
cord-267897-w4pbq2lb	333	47	"	"	''
cord-267897-w4pbq2lb	334	1	106	106	CD
cord-267897-w4pbq2lb	335	1	This	this	DT
cord-267897-w4pbq2lb	335	2	issue	issue	NN
cord-267897-w4pbq2lb	335	3	has	have	VBZ
cord-267897-w4pbq2lb	335	4	been	be	VBN
cord-267897-w4pbq2lb	335	5	extensively	extensively	RB
cord-267897-w4pbq2lb	335	6	reviewed	review	VBN
cord-267897-w4pbq2lb	335	7	previously	previously	RB
cord-267897-w4pbq2lb	335	8	.	.	.
cord-267897-w4pbq2lb	336	1	107	107	LS
cord-267897-w4pbq2lb	336	2	There	there	EX
cord-267897-w4pbq2lb	336	3	is	be	VBZ
cord-267897-w4pbq2lb	336	4	no	no	DT
cord-267897-w4pbq2lb	336	5	evidence	evidence	NN
cord-267897-w4pbq2lb	336	6	that	that	IN
cord-267897-w4pbq2lb	336	7	aluminum	aluminum	NN
cord-267897-w4pbq2lb	336	8	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	336	9	themselves	-PRON-	PRP
cord-267897-w4pbq2lb	336	10	should	should	MD
cord-267897-w4pbq2lb	336	11	be	be	VB
cord-267897-w4pbq2lb	336	12	immunogenic	immunogenic	JJ
cord-267897-w4pbq2lb	336	13	and	and	CC
cord-267897-w4pbq2lb	336	14	act	act	VB
cord-267897-w4pbq2lb	336	15	as	as	IN
cord-267897-w4pbq2lb	336	16	haptens	hapten	NNS
cord-267897-w4pbq2lb	336	17	;	;	:
cord-267897-w4pbq2lb	336	18	accordingly	accordingly	RB
cord-267897-w4pbq2lb	336	19	they	-PRON-	PRP
cord-267897-w4pbq2lb	336	20	are	be	VBP
cord-267897-w4pbq2lb	336	21	not	not	RB
cord-267897-w4pbq2lb	336	22	likely	likely	JJ
cord-267897-w4pbq2lb	336	23	to	to	TO
cord-267897-w4pbq2lb	336	24	cause	cause	VB
cord-267897-w4pbq2lb	336	25	harmful	harmful	JJ
cord-267897-w4pbq2lb	336	26	immune	immune	JJ
cord-267897-w4pbq2lb	336	27	complex	complex	JJ
cord-267897-w4pbq2lb	336	28	reactions	reaction	NNS
cord-267897-w4pbq2lb	336	29	and	and	CC
cord-267897-w4pbq2lb	336	30	observations	observation	NNS
cord-267897-w4pbq2lb	336	31	of	of	IN
cord-267897-w4pbq2lb	336	32	contact	contact	NN
cord-267897-w4pbq2lb	336	33	hypersensitivity	hypersensitivity	NN
cord-267897-w4pbq2lb	336	34	reactions	reaction	NNS
cord-267897-w4pbq2lb	336	35	are	be	VBP
cord-267897-w4pbq2lb	336	36	not	not	RB
cord-267897-w4pbq2lb	336	37	commonly	commonly	RB
cord-267897-w4pbq2lb	336	38	seen	see	VBN
cord-267897-w4pbq2lb	336	39	.	.	.
cord-267897-w4pbq2lb	337	1	2	2	LS
cord-267897-w4pbq2lb	337	2	,	,	,
cord-267897-w4pbq2lb	337	3	108	108	CD
cord-267897-w4pbq2lb	337	4	The	the	DT
cord-267897-w4pbq2lb	337	5	aluminum	aluminum	NN
cord-267897-w4pbq2lb	337	6	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	337	7	are	be	VBP
cord-267897-w4pbq2lb	337	8	not	not	RB
cord-267897-w4pbq2lb	337	9	in	in	IN
cord-267897-w4pbq2lb	337	10	themselves	-PRON-	PRP
cord-267897-w4pbq2lb	337	11	pyrogenic	pyrogenic	JJ
cord-267897-w4pbq2lb	337	12	,	,	,
cord-267897-w4pbq2lb	337	13	and	and	CC
cord-267897-w4pbq2lb	337	14	there	there	EX
cord-267897-w4pbq2lb	337	15	is	be	VBZ
cord-267897-w4pbq2lb	337	16	no	no	DT
cord-267897-w4pbq2lb	337	17	evidence	evidence	NN
cord-267897-w4pbq2lb	337	18	of	of	IN
cord-267897-w4pbq2lb	337	19	carcinogenicity	carcinogenicity	NN
cord-267897-w4pbq2lb	337	20	or	or	CC
cord-267897-w4pbq2lb	337	21	teratogenicity	teratogenicity	NN
cord-267897-w4pbq2lb	337	22	attributed	attribute	VBN
cord-267897-w4pbq2lb	337	23	to	to	IN
cord-267897-w4pbq2lb	337	24	their	-PRON-	PRP$
cord-267897-w4pbq2lb	337	25	use	use	NN
cord-267897-w4pbq2lb	337	26	.	.	.
cord-267897-w4pbq2lb	338	1	Cases	case	NNS
cord-267897-w4pbq2lb	338	2	of	of	IN
cord-267897-w4pbq2lb	338	3	local	local	JJ
cord-267897-w4pbq2lb	338	4	reactions	reaction	NNS
cord-267897-w4pbq2lb	338	5	have	have	VBP
cord-267897-w4pbq2lb	338	6	been	be	VBN
cord-267897-w4pbq2lb	338	7	reported	report	VBN
cord-267897-w4pbq2lb	338	8	.	.	.
cord-267897-w4pbq2lb	339	1	109	109	CD
cord-267897-w4pbq2lb	340	1	These	these	DT
cord-267897-w4pbq2lb	340	2	may	may	MD
cord-267897-w4pbq2lb	340	3	include	include	VB
cord-267897-w4pbq2lb	340	4	swellings	swelling	NNS
cord-267897-w4pbq2lb	340	5	,	,	,
cord-267897-w4pbq2lb	340	6	indurations	induration	NNS
cord-267897-w4pbq2lb	340	7	,	,	,
cord-267897-w4pbq2lb	340	8	erythemas	erythemas	NNP
cord-267897-w4pbq2lb	340	9	,	,	,
cord-267897-w4pbq2lb	340	10	and	and	CC
cord-267897-w4pbq2lb	340	11	cutaneous	cutaneous	JJ
cord-267897-w4pbq2lb	340	12	nodules	nodule	NNS
cord-267897-w4pbq2lb	340	13	,	,	,
cord-267897-w4pbq2lb	340	14	which	which	WDT
cord-267897-w4pbq2lb	340	15	can	can	MD
cord-267897-w4pbq2lb	340	16	persist	persist	VB
cord-267897-w4pbq2lb	340	17	for	for	IN
cord-267897-w4pbq2lb	340	18	up	up	IN
cord-267897-w4pbq2lb	340	19	to	to	TO
cord-267897-w4pbq2lb	340	20	8	8	CD
cord-267897-w4pbq2lb	340	21	weeks	week	NNS
cord-267897-w4pbq2lb	340	22	or	or	CC
cord-267897-w4pbq2lb	340	23	sometimes	sometimes	RB
cord-267897-w4pbq2lb	340	24	longer	long	RBR
cord-267897-w4pbq2lb	340	25	.	.	.
cord-267897-w4pbq2lb	341	1	110	110	CD
cord-267897-w4pbq2lb	342	1	These	these	DT
cord-267897-w4pbq2lb	342	2	reports	report	NNS
cord-267897-w4pbq2lb	342	3	often	often	RB
cord-267897-w4pbq2lb	342	4	describe	describe	VBP
cord-267897-w4pbq2lb	342	5	cases	case	NNS
cord-267897-w4pbq2lb	342	6	of	of	IN
cord-267897-w4pbq2lb	342	7	hyposensitization	hyposensitization	NN
cord-267897-w4pbq2lb	342	8	of	of	IN
cord-267897-w4pbq2lb	342	9	allergic	allergic	JJ
cord-267897-w4pbq2lb	342	10	patients	patient	NNS
cord-267897-w4pbq2lb	342	11	who	who	WP
cord-267897-w4pbq2lb	342	12	receive	receive	VBP
cord-267897-w4pbq2lb	342	13	a	a	DT
cord-267897-w4pbq2lb	342	14	large	large	JJ
cord-267897-w4pbq2lb	342	15	number	number	NN
cord-267897-w4pbq2lb	342	16	of	of	IN
cord-267897-w4pbq2lb	342	17	injections	injection	NNS
cord-267897-w4pbq2lb	342	18	of	of	IN
cord-267897-w4pbq2lb	342	19	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	342	20	allergenic	allergenic	JJ
cord-267897-w4pbq2lb	342	21	extracts	extract	NNS
cord-267897-w4pbq2lb	342	22	over	over	IN
cord-267897-w4pbq2lb	342	23	a	a	DT
cord-267897-w4pbq2lb	342	24	limited	limited	JJ
cord-267897-w4pbq2lb	342	25	period	period	NN
cord-267897-w4pbq2lb	342	26	.	.	.
cord-267897-w4pbq2lb	343	1	In	in	IN
cord-267897-w4pbq2lb	343	2	a	a	DT
cord-267897-w4pbq2lb	343	3	vaccination	vaccination	NN
cord-267897-w4pbq2lb	343	4	program	program	NN
cord-267897-w4pbq2lb	343	5	in	in	IN
cord-267897-w4pbq2lb	343	6	Sweden	Sweden	NNP
cord-267897-w4pbq2lb	343	7	,	,	,
cord-267897-w4pbq2lb	343	8	Elisabeth	Elisabeth	NNP
cord-267897-w4pbq2lb	343	9	Bergfors	Bergfors	NNP
cord-267897-w4pbq2lb	343	10	and	and	CC
cord-267897-w4pbq2lb	343	11	her	-PRON-	PRP$
cord-267897-w4pbq2lb	343	12	colleagues	colleague	NNS
cord-267897-w4pbq2lb	343	13	111	111	CD
cord-267897-w4pbq2lb	343	14	found	find	VBD
cord-267897-w4pbq2lb	343	15	itching	itch	VBG
cord-267897-w4pbq2lb	343	16	local	local	JJ
cord-267897-w4pbq2lb	343	17	reactions	reaction	NNS
cord-267897-w4pbq2lb	343	18	in	in	IN
cord-267897-w4pbq2lb	343	19	0.8	0.8	CD
cord-267897-w4pbq2lb	343	20	%	%	NN
cord-267897-w4pbq2lb	343	21	out	out	IN
cord-267897-w4pbq2lb	343	22	of	of	IN
cord-267897-w4pbq2lb	343	23	76,000	76,000	CD
cord-267897-w4pbq2lb	343	24	vaccinees	vaccinee	NNS
cord-267897-w4pbq2lb	343	25	.	.	.
cord-267897-w4pbq2lb	344	1	A	a	DT
cord-267897-w4pbq2lb	344	2	number	number	NN
cord-267897-w4pbq2lb	344	3	of	of	IN
cord-267897-w4pbq2lb	344	4	side	side	NN
cord-267897-w4pbq2lb	344	5	effects	effect	NNS
cord-267897-w4pbq2lb	344	6	observed	observe	VBN
cord-267897-w4pbq2lb	344	7	after	after	IN
cord-267897-w4pbq2lb	344	8	vaccination	vaccination	NN
cord-267897-w4pbq2lb	344	9	with	with	IN
cord-267897-w4pbq2lb	344	10	adjuvanted	adjuvante	VBN
cord-267897-w4pbq2lb	344	11	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	344	12	must	must	MD
cord-267897-w4pbq2lb	344	13	,	,	,
cord-267897-w4pbq2lb	344	14	however	however	RB
cord-267897-w4pbq2lb	344	15	,	,	,
cord-267897-w4pbq2lb	344	16	be	be	VB
cord-267897-w4pbq2lb	344	17	attributed	attribute	VBN
cord-267897-w4pbq2lb	344	18	to	to	IN
cord-267897-w4pbq2lb	344	19	the	the	DT
cord-267897-w4pbq2lb	344	20	vaccine	vaccine	NN
cord-267897-w4pbq2lb	344	21	preservatives	preservative	NNS
cord-267897-w4pbq2lb	344	22	,	,	,
cord-267897-w4pbq2lb	344	23	like	like	IN
cord-267897-w4pbq2lb	344	24	thiomersal	thiomersal	NN
cord-267897-w4pbq2lb	344	25	,	,	,
cord-267897-w4pbq2lb	344	26	betapropriolactone	betapropriolactone	NN
cord-267897-w4pbq2lb	344	27	,	,	,
cord-267897-w4pbq2lb	344	28	or	or	CC
cord-267897-w4pbq2lb	344	29	formaldehyde	formaldehyde	NN
cord-267897-w4pbq2lb	344	30	or	or	CC
cord-267897-w4pbq2lb	344	31	,	,	,
cord-267897-w4pbq2lb	344	32	as	as	IN
cord-267897-w4pbq2lb	344	33	mentioned	mention	VBN
cord-267897-w4pbq2lb	344	34	,	,	,
cord-267897-w4pbq2lb	344	35	to	to	IN
cord-267897-w4pbq2lb	344	36	bacterial	bacterial	JJ
cord-267897-w4pbq2lb	344	37	toxins	toxin	NNS
cord-267897-w4pbq2lb	344	38	from	from	IN
cord-267897-w4pbq2lb	344	39	the	the	DT
cord-267897-w4pbq2lb	344	40	antigen	antigen	NN
cord-267897-w4pbq2lb	344	41	preparation	preparation	NN
cord-267897-w4pbq2lb	344	42	.	.	.
cord-267897-w4pbq2lb	345	1	112	112	CD
cord-267897-w4pbq2lb	345	2	Significant	significant	JJ
cord-267897-w4pbq2lb	345	3	resources	resource	NNS
cord-267897-w4pbq2lb	345	4	have	have	VBP
cord-267897-w4pbq2lb	345	5	been	be	VBN
cord-267897-w4pbq2lb	345	6	spent	spend	VBN
cord-267897-w4pbq2lb	345	7	on	on	IN
cord-267897-w4pbq2lb	345	8	throwing	throw	VBG
cord-267897-w4pbq2lb	345	9	light	light	NN
cord-267897-w4pbq2lb	345	10	on	on	IN
cord-267897-w4pbq2lb	345	11	a	a	DT
cord-267897-w4pbq2lb	345	12	possible	possible	JJ
cord-267897-w4pbq2lb	345	13	link	link	NN
cord-267897-w4pbq2lb	345	14	between	between	IN
cord-267897-w4pbq2lb	345	15	aluminum	aluminum	NN
cord-267897-w4pbq2lb	345	16	exposure	exposure	NN
cord-267897-w4pbq2lb	345	17	and	and	CC
cord-267897-w4pbq2lb	345	18	the	the	DT
cord-267897-w4pbq2lb	345	19	prevalence	prevalence	NN
cord-267897-w4pbq2lb	345	20	of	of	IN
cord-267897-w4pbq2lb	345	21	Alzheimer	Alzheimer	NNP
cord-267897-w4pbq2lb	345	22	disease	disease	NN
cord-267897-w4pbq2lb	345	23	.	.	.
cord-267897-w4pbq2lb	346	1	103	103	CD
cord-267897-w4pbq2lb	347	1	Some	some	DT
cord-267897-w4pbq2lb	347	2	researchers	researcher	NNS
cord-267897-w4pbq2lb	347	3	found	find	VBD
cord-267897-w4pbq2lb	347	4	aluminum	aluminum	NN
cord-267897-w4pbq2lb	347	5	deposits	deposit	NNS
cord-267897-w4pbq2lb	347	6	in	in	IN
cord-267897-w4pbq2lb	347	7	AD	ad	NN
cord-267897-w4pbq2lb	347	8	brain	brain	NN
cord-267897-w4pbq2lb	347	9	tissue	tissue	NN
cord-267897-w4pbq2lb	347	10	biopsies	biopsy	NNS
cord-267897-w4pbq2lb	347	11	,	,	,
cord-267897-w4pbq2lb	347	12	113	113	CD
cord-267897-w4pbq2lb	347	13	,	,	,
cord-267897-w4pbq2lb	347	14	114	114	CD
cord-267897-w4pbq2lb	347	15	whereas	whereas	IN
cord-267897-w4pbq2lb	347	16	others	other	NNS
cord-267897-w4pbq2lb	347	17	have	have	VBP
cord-267897-w4pbq2lb	347	18	not	not	RB
cord-267897-w4pbq2lb	347	19	.	.	.
cord-267897-w4pbq2lb	348	1	115	115	CD
cord-267897-w4pbq2lb	348	2	,	,	,
cord-267897-w4pbq2lb	348	3	116	116	CD
cord-267897-w4pbq2lb	349	1	In	in	IN
cord-267897-w4pbq2lb	349	2	a	a	DT
cord-267897-w4pbq2lb	349	3	later	later	JJ
cord-267897-w4pbq2lb	349	4	report	report	NN
cord-267897-w4pbq2lb	349	5	,	,	,
cord-267897-w4pbq2lb	349	6	it	-PRON-	PRP
cord-267897-w4pbq2lb	349	7	was	be	VBD
cord-267897-w4pbq2lb	349	8	suggested	suggest	VBN
cord-267897-w4pbq2lb	349	9	that	that	IN
cord-267897-w4pbq2lb	349	10	the	the	DT
cord-267897-w4pbq2lb	349	11	aluminum	aluminum	NN
cord-267897-w4pbq2lb	349	12	detection	detection	NN
cord-267897-w4pbq2lb	349	13	was	be	VBD
cord-267897-w4pbq2lb	349	14	an	an	DT
cord-267897-w4pbq2lb	349	15	artifact	artifact	NN
cord-267897-w4pbq2lb	349	16	caused	cause	VBN
cord-267897-w4pbq2lb	349	17	by	by	IN
cord-267897-w4pbq2lb	349	18	the	the	DT
cord-267897-w4pbq2lb	349	19	staining	stain	VBG
cord-267897-w4pbq2lb	349	20	reagents	reagent	NNS
cord-267897-w4pbq2lb	349	21	used	use	VBN
cord-267897-w4pbq2lb	349	22	in	in	IN
cord-267897-w4pbq2lb	349	23	the	the	DT
cord-267897-w4pbq2lb	349	24	preparation	preparation	NN
cord-267897-w4pbq2lb	349	25	of	of	IN
cord-267897-w4pbq2lb	349	26	the	the	DT
cord-267897-w4pbq2lb	349	27	specimen	specimen	NN
cord-267897-w4pbq2lb	349	28	.	.	.
cord-267897-w4pbq2lb	350	1	117	117	CD
cord-267897-w4pbq2lb	351	1	The	the	DT
cord-267897-w4pbq2lb	351	2	Canadian	canadian	JJ
cord-267897-w4pbq2lb	351	3	Alzheimer	Alzheimer	NNP
cord-267897-w4pbq2lb	351	4	Society	Society	NNP
cord-267897-w4pbq2lb	352	1	(	(	-LRB-
cord-267897-w4pbq2lb	352	2	http://www.Alzheimer.ca/en/Research/	http://www.Alzheimer.ca/en/Research/	NNP
cord-267897-w4pbq2lb	352	3	Alzheimer	Alzheimer	NNP
cord-267897-w4pbq2lb	352	4	-	-	HYPH
cord-267897-w4pbq2lb	352	5	s	s	POS
cord-267897-w4pbq2lb	352	6	-	-	HYPH
cord-267897-w4pbq2lb	352	7	disease	disease	NN
cord-267897-w4pbq2lb	352	8	-	-	HYPH
cord-267897-w4pbq2lb	352	9	research	research	NN
cord-267897-w4pbq2lb	352	10	/	/	SYM
cord-267897-w4pbq2lb	352	11	Aluminum	Aluminum	NNP
cord-267897-w4pbq2lb	352	12	)	)	-RRB-
cord-267897-w4pbq2lb	352	13	concluded	conclude	VBD
cord-267897-w4pbq2lb	352	14	on	on	IN
cord-267897-w4pbq2lb	352	15	their	-PRON-	PRP$
cord-267897-w4pbq2lb	352	16	webpage	webpage	NN
cord-267897-w4pbq2lb	352	17	:	:	:
cord-267897-w4pbq2lb	352	18	"	"	``
cord-267897-w4pbq2lb	352	19	At	at	IN
cord-267897-w4pbq2lb	352	20	this	this	DT
cord-267897-w4pbq2lb	352	21	point	point	NN
cord-267897-w4pbq2lb	352	22	,	,	,
cord-267897-w4pbq2lb	352	23	there	there	EX
cord-267897-w4pbq2lb	352	24	is	be	VBZ
cord-267897-w4pbq2lb	352	25	no	no	DT
cord-267897-w4pbq2lb	352	26	convincing	convincing	JJ
cord-267897-w4pbq2lb	352	27	evidence	evidence	NN
cord-267897-w4pbq2lb	352	28	that	that	IN
cord-267897-w4pbq2lb	352	29	aluminum	aluminum	NN
cord-267897-w4pbq2lb	352	30	increases	increase	VBZ
cord-267897-w4pbq2lb	352	31	a	a	DT
cord-267897-w4pbq2lb	352	32	person	person	NN
cord-267897-w4pbq2lb	352	33	's	's	POS
cord-267897-w4pbq2lb	352	34	risk	risk	NN
cord-267897-w4pbq2lb	352	35	of	of	IN
cord-267897-w4pbq2lb	352	36	developing	develop	VBG
cord-267897-w4pbq2lb	352	37	Alzheimer	Alzheimer	NNP
cord-267897-w4pbq2lb	352	38	's	's	POS
cord-267897-w4pbq2lb	352	39	disease	disease	NN
cord-267897-w4pbq2lb	352	40	.	.	.
cord-267897-w4pbq2lb	353	1	"	"	''
cord-267897-w4pbq2lb	354	1	Aluminum	aluminum	NN
cord-267897-w4pbq2lb	354	2	and	and	CC
cord-267897-w4pbq2lb	354	3	calcium	calcium	NN
cord-267897-w4pbq2lb	354	4	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	354	5	should	should	MD
cord-267897-w4pbq2lb	354	6	,	,	,
cord-267897-w4pbq2lb	354	7	along	along	IN
cord-267897-w4pbq2lb	354	8	with	with	IN
cord-267897-w4pbq2lb	354	9	water	water	NN
cord-267897-w4pbq2lb	354	10	-	-	HYPH
cord-267897-w4pbq2lb	354	11	in	in	IN
cord-267897-w4pbq2lb	354	12	-	-	HYPH
cord-267897-w4pbq2lb	354	13	oil	oil	NN
cord-267897-w4pbq2lb	354	14	emulsions	emulsion	NNS
cord-267897-w4pbq2lb	354	15	,	,	,
cord-267897-w4pbq2lb	354	16	be	be	VB
cord-267897-w4pbq2lb	354	17	regarded	regard	VBN
cord-267897-w4pbq2lb	354	18	as	as	IN
cord-267897-w4pbq2lb	354	19	depot	depot	NN
cord-267897-w4pbq2lb	354	20	-	-	HYPH
cord-267897-w4pbq2lb	354	21	forming	form	VBG
cord-267897-w4pbq2lb	354	22	or	or	CC
cord-267897-w4pbq2lb	354	23	repository	repository	NN
cord-267897-w4pbq2lb	354	24	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	354	25	.	.	.
cord-267897-w4pbq2lb	355	1	With	with	IN
cord-267897-w4pbq2lb	355	2	these	these	DT
cord-267897-w4pbq2lb	355	3	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	355	4	the	the	DT
cord-267897-w4pbq2lb	355	5	formation	formation	NN
cord-267897-w4pbq2lb	355	6	of	of	IN
cord-267897-w4pbq2lb	355	7	a	a	DT
cord-267897-w4pbq2lb	355	8	temporary	temporary	JJ
cord-267897-w4pbq2lb	355	9	inflammatory	inflammatory	JJ
cord-267897-w4pbq2lb	355	10	focus	focus	NN
cord-267897-w4pbq2lb	355	11	attracting	attract	VBG
cord-267897-w4pbq2lb	355	12	immunocompetent	immunocompetent	JJ
cord-267897-w4pbq2lb	355	13	cells	cell	NNS
cord-267897-w4pbq2lb	355	14	shortly	shortly	RB
cord-267897-w4pbq2lb	355	15	after	after	IN
cord-267897-w4pbq2lb	355	16	injection	injection	NN
cord-267897-w4pbq2lb	355	17	must	must	MD
cord-267897-w4pbq2lb	355	18	be	be	VB
cord-267897-w4pbq2lb	355	19	expected	expect	VBN
cord-267897-w4pbq2lb	355	20	.	.	.
cord-267897-w4pbq2lb	356	1	1	1	CD
cord-267897-w4pbq2lb	356	2	,	,	,
cord-267897-w4pbq2lb	356	3	118	118	CD
cord-267897-w4pbq2lb	356	4	Upon	upon	IN
cord-267897-w4pbq2lb	356	5	injection	injection	NN
cord-267897-w4pbq2lb	356	6	macrophages	macrophage	NNS
cord-267897-w4pbq2lb	356	7	are	be	VBP
cord-267897-w4pbq2lb	356	8	attracted	attract	VBN
cord-267897-w4pbq2lb	356	9	to	to	IN
cord-267897-w4pbq2lb	356	10	the	the	DT
cord-267897-w4pbq2lb	356	11	site	site	NN
cord-267897-w4pbq2lb	356	12	to	to	TO
cord-267897-w4pbq2lb	356	13	phagocytize	phagocytize	VB
cord-267897-w4pbq2lb	356	14	and	and	CC
cord-267897-w4pbq2lb	356	15	clear	clear	VB
cord-267897-w4pbq2lb	356	16	the	the	DT
cord-267897-w4pbq2lb	356	17	inoculum	inoculum	NN
cord-267897-w4pbq2lb	356	18	.	.	.
cord-267897-w4pbq2lb	357	1	The	the	DT
cord-267897-w4pbq2lb	357	2	local	local	JJ
cord-267897-w4pbq2lb	357	3	reaction	reaction	NN
cord-267897-w4pbq2lb	357	4	may	may	MD
cord-267897-w4pbq2lb	357	5	be	be	VB
cord-267897-w4pbq2lb	357	6	negligible	negligible	JJ
cord-267897-w4pbq2lb	357	7	if	if	IN
cord-267897-w4pbq2lb	357	8	the	the	DT
cord-267897-w4pbq2lb	357	9	inoculum	inoculum	NN
cord-267897-w4pbq2lb	357	10	is	be	VBZ
cord-267897-w4pbq2lb	357	11	rapidly	rapidly	RB
cord-267897-w4pbq2lb	357	12	dispersed	disperse	VBN
cord-267897-w4pbq2lb	357	13	from	from	IN
cord-267897-w4pbq2lb	357	14	the	the	DT
cord-267897-w4pbq2lb	357	15	injection	injection	NN
cord-267897-w4pbq2lb	357	16	site	site	NN
cord-267897-w4pbq2lb	357	17	.	.	.
cord-267897-w4pbq2lb	358	1	However	however	RB
cord-267897-w4pbq2lb	358	2	,	,	,
cord-267897-w4pbq2lb	358	3	if	if	IN
cord-267897-w4pbq2lb	358	4	the	the	DT
cord-267897-w4pbq2lb	358	5	inoculum	inoculum	NN
cord-267897-w4pbq2lb	358	6	resides	reside	VBZ
cord-267897-w4pbq2lb	358	7	for	for	IN
cord-267897-w4pbq2lb	358	8	a	a	DT
cord-267897-w4pbq2lb	358	9	prolonged	prolonged	JJ
cord-267897-w4pbq2lb	358	10	period	period	NN
cord-267897-w4pbq2lb	358	11	at	at	IN
cord-267897-w4pbq2lb	358	12	the	the	DT
cord-267897-w4pbq2lb	358	13	injection	injection	NN
cord-267897-w4pbq2lb	358	14	site	site	NN
cord-267897-w4pbq2lb	358	15	(	(	-LRB-
cord-267897-w4pbq2lb	358	16	as	as	IN
cord-267897-w4pbq2lb	358	17	is	be	VBZ
cord-267897-w4pbq2lb	358	18	the	the	DT
cord-267897-w4pbq2lb	358	19	case	case	NN
cord-267897-w4pbq2lb	358	20	with	with	IN
cord-267897-w4pbq2lb	358	21	repository	repository	NN
cord-267897-w4pbq2lb	358	22	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	358	23	like	like	IN
cord-267897-w4pbq2lb	358	24	mineral	mineral	NN
cord-267897-w4pbq2lb	358	25	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	358	26	or	or	CC
cord-267897-w4pbq2lb	358	27	water	water	NN
cord-267897-w4pbq2lb	358	28	-	-	HYPH
cord-267897-w4pbq2lb	358	29	in	in	IN
cord-267897-w4pbq2lb	358	30	-	-	HYPH
cord-267897-w4pbq2lb	358	31	oil	oil	NN
cord-267897-w4pbq2lb	358	32	emulsions	emulsion	NNS
cord-267897-w4pbq2lb	358	33	)	)	-RRB-
cord-267897-w4pbq2lb	358	34	,	,	,
cord-267897-w4pbq2lb	358	35	then	then	RB
cord-267897-w4pbq2lb	358	36	in	in	IN
cord-267897-w4pbq2lb	358	37	situ	situ	JJ
cord-267897-w4pbq2lb	358	38	accumulation	accumulation	NN
cord-267897-w4pbq2lb	358	39	of	of	IN
cord-267897-w4pbq2lb	358	40	phagocytic	phagocytic	JJ
cord-267897-w4pbq2lb	358	41	and	and	CC
cord-267897-w4pbq2lb	358	42	immunocompetent	immunocompetent	JJ
cord-267897-w4pbq2lb	358	43	cells	cell	NNS
cord-267897-w4pbq2lb	358	44	may	may	MD
cord-267897-w4pbq2lb	358	45	in	in	IN
cord-267897-w4pbq2lb	358	46	some	some	DT
cord-267897-w4pbq2lb	358	47	cases	case	NNS
cord-267897-w4pbq2lb	358	48	manifest	manifest	VBP
cord-267897-w4pbq2lb	358	49	itself	-PRON-	PRP
cord-267897-w4pbq2lb	358	50	as	as	IN
cord-267897-w4pbq2lb	358	51	an	an	DT
cord-267897-w4pbq2lb	358	52	inflammatory	inflammatory	JJ
cord-267897-w4pbq2lb	358	53	focus	focus	NN
cord-267897-w4pbq2lb	358	54	accompanied	accompany	VBN
cord-267897-w4pbq2lb	358	55	by	by	IN
cord-267897-w4pbq2lb	358	56	a	a	DT
cord-267897-w4pbq2lb	358	57	transient	transient	JJ
cord-267897-w4pbq2lb	358	58	swelling	swelling	NN
cord-267897-w4pbq2lb	358	59	,	,	,
cord-267897-w4pbq2lb	358	60	local	local	JJ
cord-267897-w4pbq2lb	358	61	irritation	irritation	NN
cord-267897-w4pbq2lb	358	62	,	,	,
cord-267897-w4pbq2lb	358	63	and	and	CC
cord-267897-w4pbq2lb	358	64	redness	redness	NN
cord-267897-w4pbq2lb	358	65	.	.	.
cord-267897-w4pbq2lb	359	1	Some	some	DT
cord-267897-w4pbq2lb	359	2	observations	observation	NNS
cord-267897-w4pbq2lb	359	3	of	of	IN
cord-267897-w4pbq2lb	359	4	aluminum	aluminum	NN
cord-267897-w4pbq2lb	359	5	-	-	HYPH
cord-267897-w4pbq2lb	359	6	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	359	7	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	359	8	giving	give	VBG
cord-267897-w4pbq2lb	359	9	rise	rise	NN
cord-267897-w4pbq2lb	359	10	to	to	IN
cord-267897-w4pbq2lb	359	11	more	more	JJR
cord-267897-w4pbq2lb	359	12	local	local	JJ
cord-267897-w4pbq2lb	359	13	reactions	reaction	NNS
cord-267897-w4pbq2lb	359	14	than	than	IN
cord-267897-w4pbq2lb	359	15	unadsorbed	unadsorbed	JJ
cord-267897-w4pbq2lb	359	16	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	359	17	with	with	IN
cord-267897-w4pbq2lb	359	18	plain	plain	JJ
cord-267897-w4pbq2lb	359	19	toxoid	toxoid	NN
cord-267897-w4pbq2lb	359	20	119	119	CD
cord-267897-w4pbq2lb	359	21	could	could	MD
cord-267897-w4pbq2lb	359	22	in	in	IN
cord-267897-w4pbq2lb	359	23	part	part	NN
cord-267897-w4pbq2lb	359	24	be	be	VB
cord-267897-w4pbq2lb	359	25	explained	explain	VBN
cord-267897-w4pbq2lb	359	26	by	by	IN
cord-267897-w4pbq2lb	359	27	the	the	DT
cord-267897-w4pbq2lb	359	28	plain	plain	JJ
cord-267897-w4pbq2lb	359	29	toxoid	toxoid	NN
cord-267897-w4pbq2lb	359	30	vaccine	vaccine	NN
cord-267897-w4pbq2lb	359	31	being	be	VBG
cord-267897-w4pbq2lb	359	32	dispersed	disperse	VBN
cord-267897-w4pbq2lb	359	33	from	from	IN
cord-267897-w4pbq2lb	359	34	the	the	DT
cord-267897-w4pbq2lb	359	35	injection	injection	NN
cord-267897-w4pbq2lb	359	36	site	site	NN
cord-267897-w4pbq2lb	359	37	before	before	IN
cord-267897-w4pbq2lb	359	38	a	a	DT
cord-267897-w4pbq2lb	359	39	local	local	JJ
cord-267897-w4pbq2lb	359	40	reaction	reaction	NN
cord-267897-w4pbq2lb	359	41	was	be	VBD
cord-267897-w4pbq2lb	359	42	established	establish	VBN
cord-267897-w4pbq2lb	359	43	.	.	.
cord-267897-w4pbq2lb	360	1	Any	any	DT
cord-267897-w4pbq2lb	360	2	visible	visible	JJ
cord-267897-w4pbq2lb	360	3	or	or	CC
cord-267897-w4pbq2lb	360	4	palpable	palpable	JJ
cord-267897-w4pbq2lb	360	5	reaction	reaction	NN
cord-267897-w4pbq2lb	360	6	at	at	IN
cord-267897-w4pbq2lb	360	7	the	the	DT
cord-267897-w4pbq2lb	360	8	injection	injection	NN
cord-267897-w4pbq2lb	360	9	site	site	NN
cord-267897-w4pbq2lb	360	10	is	be	VBZ
cord-267897-w4pbq2lb	360	11	in	in	IN
cord-267897-w4pbq2lb	360	12	principle	principle	JJ
cord-267897-w4pbq2lb	360	13	non	non	FW
cord-267897-w4pbq2lb	360	14	grata	grata	FW
cord-267897-w4pbq2lb	360	15	,	,	,
cord-267897-w4pbq2lb	360	16	as	as	IN
cord-267897-w4pbq2lb	360	17	it	-PRON-	PRP
cord-267897-w4pbq2lb	360	18	hinders	hinder	VBZ
cord-267897-w4pbq2lb	360	19	the	the	DT
cord-267897-w4pbq2lb	360	20	obtaining	obtaining	NN
cord-267897-w4pbq2lb	360	21	of	of	IN
cord-267897-w4pbq2lb	360	22	a	a	DT
cord-267897-w4pbq2lb	360	23	hypothetical	hypothetical	JJ
cord-267897-w4pbq2lb	360	24	and	and	CC
cord-267897-w4pbq2lb	360	25	nonreactogenic	nonreactogenic	JJ
cord-267897-w4pbq2lb	360	26	"	"	''
cord-267897-w4pbq2lb	360	27	ideal	ideal	JJ
cord-267897-w4pbq2lb	360	28	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	360	29	.	.	.
cord-267897-w4pbq2lb	360	30	"	"	''
cord-267897-w4pbq2lb	361	1	However	however	RB
cord-267897-w4pbq2lb	361	2	,	,	,
cord-267897-w4pbq2lb	361	3	it	-PRON-	PRP
cord-267897-w4pbq2lb	361	4	is	be	VBZ
cord-267897-w4pbq2lb	361	5	important	important	JJ
cord-267897-w4pbq2lb	361	6	to	to	TO
cord-267897-w4pbq2lb	361	7	realize	realize	VB
cord-267897-w4pbq2lb	361	8	that	that	IN
cord-267897-w4pbq2lb	361	9	the	the	DT
cord-267897-w4pbq2lb	361	10	mechanisms	mechanism	NNS
cord-267897-w4pbq2lb	361	11	described	describe	VBN
cord-267897-w4pbq2lb	361	12	are	be	VBP
cord-267897-w4pbq2lb	361	13	part	part	NN
cord-267897-w4pbq2lb	361	14	of	of	IN
cord-267897-w4pbq2lb	361	15	a	a	DT
cord-267897-w4pbq2lb	361	16	normally	normally	RB
cord-267897-w4pbq2lb	361	17	functioning	function	VBG
cord-267897-w4pbq2lb	361	18	immune	immune	JJ
cord-267897-w4pbq2lb	361	19	system	system	NN
cord-267897-w4pbq2lb	361	20	.	.	.
cord-267897-w4pbq2lb	362	1	Hence	hence	RB
cord-267897-w4pbq2lb	362	2	,	,	,
cord-267897-w4pbq2lb	362	3	use	use	NN
cord-267897-w4pbq2lb	362	4	of	of	IN
cord-267897-w4pbq2lb	362	5	repository	repository	NN
cord-267897-w4pbq2lb	362	6	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	362	7	without	without	IN
cord-267897-w4pbq2lb	362	8	temporarily	temporarily	RB
cord-267897-w4pbq2lb	362	9	also	also	RB
cord-267897-w4pbq2lb	362	10	inducing	induce	VBG
cord-267897-w4pbq2lb	362	11	an	an	DT
cord-267897-w4pbq2lb	362	12	inflammatory	inflammatory	JJ
cord-267897-w4pbq2lb	362	13	focus	focus	NN
cord-267897-w4pbq2lb	362	14	around	around	IN
cord-267897-w4pbq2lb	362	15	the	the	DT
cord-267897-w4pbq2lb	362	16	inoculum	inoculum	NN
cord-267897-w4pbq2lb	362	17	may	may	MD
cord-267897-w4pbq2lb	362	18	not	not	RB
cord-267897-w4pbq2lb	362	19	be	be	VB
cord-267897-w4pbq2lb	362	20	achievable	achievable	JJ
cord-267897-w4pbq2lb	362	21	.	.	.
cord-267897-w4pbq2lb	363	1	There	there	EX
cord-267897-w4pbq2lb	363	2	are	be	VBP
cord-267897-w4pbq2lb	363	3	inconsistent	inconsistent	JJ
cord-267897-w4pbq2lb	363	4	observations	observation	NNS
cord-267897-w4pbq2lb	363	5	regarding	regard	VBG
cord-267897-w4pbq2lb	363	6	whether	whether	IN
cord-267897-w4pbq2lb	363	7	adsorption	adsorption	NN
cord-267897-w4pbq2lb	363	8	onto	onto	IN
cord-267897-w4pbq2lb	363	9	aluminum	aluminum	NN
cord-267897-w4pbq2lb	363	10	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	363	11	leads	lead	VBZ
cord-267897-w4pbq2lb	363	12	to	to	IN
cord-267897-w4pbq2lb	363	13	increased	increase	VBN
cord-267897-w4pbq2lb	363	14	or	or	CC
cord-267897-w4pbq2lb	363	15	decreased	decrease	VBD
cord-267897-w4pbq2lb	363	16	vaccine	vaccine	NN
cord-267897-w4pbq2lb	363	17	reactogenicity	reactogenicity	NN
cord-267897-w4pbq2lb	363	18	.	.	.
cord-267897-w4pbq2lb	364	1	119,120	119,120	CD
cord-267897-w4pbq2lb	365	1	However	however	RB
cord-267897-w4pbq2lb	365	2	,	,	,
cord-267897-w4pbq2lb	365	3	Butler	Butler	NNP
cord-267897-w4pbq2lb	365	4	et	et	NNP
cord-267897-w4pbq2lb	365	5	al	al	NNP
cord-267897-w4pbq2lb	365	6	.	.	.
cord-267897-w4pbq2lb	366	1	found	find	VBD
cord-267897-w4pbq2lb	366	2	that	that	IN
cord-267897-w4pbq2lb	366	3	adsorption	adsorption	NN
cord-267897-w4pbq2lb	366	4	onto	onto	IN
cord-267897-w4pbq2lb	366	5	aluminum	aluminum	NN
cord-267897-w4pbq2lb	366	6	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	367	1	(	(	-LRB-
cord-267897-w4pbq2lb	367	2	Alhydrogel	Alhydrogel	NNP
cord-267897-w4pbq2lb	367	3	)	)	-RRB-
cord-267897-w4pbq2lb	367	4	significantly	significantly	RB
cord-267897-w4pbq2lb	367	5	reduced	reduce	VBD
cord-267897-w4pbq2lb	367	6	the	the	DT
cord-267897-w4pbq2lb	367	7	side	side	NN
cord-267897-w4pbq2lb	367	8	effects	effect	NNS
cord-267897-w4pbq2lb	367	9	with	with	IN
cord-267897-w4pbq2lb	367	10	combined	combine	VBN
cord-267897-w4pbq2lb	367	11	diphteria	diphteria	NN
cord-267897-w4pbq2lb	367	12	-	-	HYPH
cord-267897-w4pbq2lb	367	13	tetanus	tetanus	NN
cord-267897-w4pbq2lb	367	14	-	-	HYPH
cord-267897-w4pbq2lb	367	15	pertussis	pertussis	NN
cord-267897-w4pbq2lb	367	16	(	(	-LRB-
cord-267897-w4pbq2lb	367	17	DTP	DTP	NNP
cord-267897-w4pbq2lb	367	18	)	)	-RRB-
cord-267897-w4pbq2lb	367	19	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	367	20	.	.	.
cord-267897-w4pbq2lb	368	1	121	121	CD
cord-267897-w4pbq2lb	369	1	The	the	DT
cord-267897-w4pbq2lb	369	2	binding	bind	VBG
cord-267897-w4pbq2lb	369	3	affinity	affinity	NN
cord-267897-w4pbq2lb	369	4	of	of	IN
cord-267897-w4pbq2lb	369	5	lipopolysaccharide	lipopolysaccharide	NN
cord-267897-w4pbq2lb	369	6	(	(	-LRB-
cord-267897-w4pbq2lb	369	7	LPS	LPS	NNP
cord-267897-w4pbq2lb	369	8	)	)	-RRB-
cord-267897-w4pbq2lb	369	9	to	to	TO
cord-267897-w4pbq2lb	369	10	aluminum	aluminum	VB
cord-267897-w4pbq2lb	369	11	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	369	12	is	be	VBZ
cord-267897-w4pbq2lb	369	13	well	well	RB
cord-267897-w4pbq2lb	369	14	established	establish	VBN
cord-267897-w4pbq2lb	369	15	and	and	CC
cord-267897-w4pbq2lb	369	16	was	be	VBD
cord-267897-w4pbq2lb	369	17	much	much	RB
cord-267897-w4pbq2lb	369	18	higher	high	JJR
cord-267897-w4pbq2lb	369	19	,	,	,
cord-267897-w4pbq2lb	369	20	than	than	IN
cord-267897-w4pbq2lb	369	21	to	to	TO
cord-267897-w4pbq2lb	369	22	aluminum	aluminum	NN
cord-267897-w4pbq2lb	369	23	phosphate	phosphate	NN
cord-267897-w4pbq2lb	369	24	,	,	,
cord-267897-w4pbq2lb	369	25	approximately	approximately	RB
cord-267897-w4pbq2lb	369	26	280	280	CD
cord-267897-w4pbq2lb	369	27	mg/	mg/	NN
cord-267897-w4pbq2lb	370	1	mg	mg	NNP
cord-267897-w4pbq2lb	371	1	Al	Al	NNP
cord-267897-w4pbq2lb	371	2	versus	versus	IN
cord-267897-w4pbq2lb	371	3	approximately	approximately	RB
cord-267897-w4pbq2lb	371	4	3	3	CD
cord-267897-w4pbq2lb	371	5	mg	mg	NNP
cord-267897-w4pbq2lb	371	6	/	/	SYM
cord-267897-w4pbq2lb	371	7	mg	mg	NNP
cord-267897-w4pbq2lb	372	1	Al	Al	NNP
cord-267897-w4pbq2lb	372	2	.	.	.
cord-267897-w4pbq2lb	373	1	122	122	CD
cord-267897-w4pbq2lb	374	1	This	this	DT
cord-267897-w4pbq2lb	374	2	difference	difference	NN
cord-267897-w4pbq2lb	374	3	is	be	VBZ
cord-267897-w4pbq2lb	374	4	ascribed	ascribe	VBN
cord-267897-w4pbq2lb	374	5	to	to	IN
cord-267897-w4pbq2lb	374	6	the	the	DT
cord-267897-w4pbq2lb	374	7	phosphate	phosphate	NN
cord-267897-w4pbq2lb	374	8	groups	group	NNS
cord-267897-w4pbq2lb	374	9	of	of	IN
cord-267897-w4pbq2lb	374	10	LPS	LPS	NNP
cord-267897-w4pbq2lb	374	11	giving	give	VBG
cord-267897-w4pbq2lb	374	12	a	a	DT
cord-267897-w4pbq2lb	374	13	higher	high	JJR
cord-267897-w4pbq2lb	374	14	degree	degree	NN
cord-267897-w4pbq2lb	374	15	of	of	IN
cord-267897-w4pbq2lb	374	16	ligand	ligand	NN
cord-267897-w4pbq2lb	374	17	exchange	exchange	NN
cord-267897-w4pbq2lb	374	18	with	with	IN
cord-267897-w4pbq2lb	374	19	aluminum	aluminum	NN
cord-267897-w4pbq2lb	374	20	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	374	21	than	than	IN
cord-267897-w4pbq2lb	374	22	with	with	IN
cord-267897-w4pbq2lb	374	23	aluminum	aluminum	NN
cord-267897-w4pbq2lb	374	24	phosphate	phosphate	NN
cord-267897-w4pbq2lb	374	25	.	.	.
cord-267897-w4pbq2lb	375	1	It	-PRON-	PRP
cord-267897-w4pbq2lb	375	2	is	be	VBZ
cord-267897-w4pbq2lb	375	3	conceivable	conceivable	JJ
cord-267897-w4pbq2lb	375	4	that	that	IN
cord-267897-w4pbq2lb	375	5	the	the	DT
cord-267897-w4pbq2lb	375	6	acute	acute	JJ
cord-267897-w4pbq2lb	375	7	toxicity	toxicity	NN
cord-267897-w4pbq2lb	375	8	is	be	VBZ
cord-267897-w4pbq2lb	375	9	reduced	reduce	VBN
cord-267897-w4pbq2lb	375	10	in	in	IN
cord-267897-w4pbq2lb	375	11	adsorbed	adsorbed	JJ
cord-267897-w4pbq2lb	375	12	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	375	13	simply	simply	RB
cord-267897-w4pbq2lb	375	14	by	by	IN
cord-267897-w4pbq2lb	375	15	a	a	DT
cord-267897-w4pbq2lb	375	16	delayed	delay	VBN
cord-267897-w4pbq2lb	375	17	release	release	NN
cord-267897-w4pbq2lb	375	18	of	of	IN
cord-267897-w4pbq2lb	375	19	toxic	toxic	JJ
cord-267897-w4pbq2lb	375	20	vaccine	vaccine	NN
cord-267897-w4pbq2lb	375	21	constituents	constituent	NNS
cord-267897-w4pbq2lb	375	22	,	,	,
cord-267897-w4pbq2lb	375	23	like	like	IN
cord-267897-w4pbq2lb	375	24	pertussis	pertussis	NN
cord-267897-w4pbq2lb	375	25	toxin	toxin	NN
cord-267897-w4pbq2lb	375	26	,	,	,
cord-267897-w4pbq2lb	375	27	peptidoglycans	peptidoglycan	NNS
cord-267897-w4pbq2lb	375	28	from	from	IN
cord-267897-w4pbq2lb	375	29	gramnegative	gramnegative	JJ
cord-267897-w4pbq2lb	375	30	cell	cell	NN
cord-267897-w4pbq2lb	375	31	walls	wall	NNS
cord-267897-w4pbq2lb	375	32	,	,	,
cord-267897-w4pbq2lb	375	33	or	or	CC
cord-267897-w4pbq2lb	375	34	LPS	lp	NNS
cord-267897-w4pbq2lb	375	35	from	from	IN
cord-267897-w4pbq2lb	375	36	the	the	DT
cord-267897-w4pbq2lb	375	37	injection	injection	NN
cord-267897-w4pbq2lb	375	38	site	site	NN
cord-267897-w4pbq2lb	375	39	.	.	.
cord-267897-w4pbq2lb	376	1	Norimatsu	Norimatsu	NNP
cord-267897-w4pbq2lb	376	2	found	find	VBD
cord-267897-w4pbq2lb	376	3	that	that	IN
cord-267897-w4pbq2lb	376	4	adsorption	adsorption	NN
cord-267897-w4pbq2lb	376	5	of	of	IN
cord-267897-w4pbq2lb	376	6	LPS	LPS	NNP
cord-267897-w4pbq2lb	376	7	onto	onto	IN
cord-267897-w4pbq2lb	376	8	aluminum	aluminum	NN
cord-267897-w4pbq2lb	376	9	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	376	10	prior	prior	RB
cord-267897-w4pbq2lb	376	11	to	to	IN
cord-267897-w4pbq2lb	376	12	injection	injection	NN
cord-267897-w4pbq2lb	376	13	inhibited	inhibit	VBN
cord-267897-w4pbq2lb	376	14	or	or	CC
cord-267897-w4pbq2lb	376	15	mitigated	mitigate	VBN
cord-267897-w4pbq2lb	376	16	systemic	systemic	JJ
cord-267897-w4pbq2lb	376	17	effects	effect	NNS
cord-267897-w4pbq2lb	376	18	like	like	IN
cord-267897-w4pbq2lb	376	19	the	the	DT
cord-267897-w4pbq2lb	376	20	trembling	tremble	VBG
cord-267897-w4pbq2lb	376	21	,	,	,
cord-267897-w4pbq2lb	376	22	transient	transient	JJ
cord-267897-w4pbq2lb	376	23	leucopenia	leucopenia	NNS
cord-267897-w4pbq2lb	376	24	and	and	CC
cord-267897-w4pbq2lb	376	25	elevated	elevated	JJ
cord-267897-w4pbq2lb	376	26	serum	serum	NN
cord-267897-w4pbq2lb	376	27	TNF	tnf	NN
cord-267897-w4pbq2lb	376	28	-	-	:
cord-267897-w4pbq2lb	376	29	a	a	DT
cord-267897-w4pbq2lb	376	30	otherwise	otherwise	RB
cord-267897-w4pbq2lb	376	31	observed	observed	JJ
cord-267897-w4pbq2lb	376	32	following	follow	VBG
cord-267897-w4pbq2lb	376	33	IM	im	JJ
cord-267897-w4pbq2lb	376	34	injection	injection	NN
cord-267897-w4pbq2lb	376	35	of	of	IN
cord-267897-w4pbq2lb	376	36	LPS	LPS	NNP
cord-267897-w4pbq2lb	376	37	in	in	IN
cord-267897-w4pbq2lb	376	38	saline	saline	NN
cord-267897-w4pbq2lb	376	39	.	.	.
cord-267897-w4pbq2lb	377	1	123	123	CD
cord-267897-w4pbq2lb	378	1	Also	also	RB
cord-267897-w4pbq2lb	378	2	,	,	,
cord-267897-w4pbq2lb	378	3	the	the	DT
cord-267897-w4pbq2lb	378	4	level	level	NN
cord-267897-w4pbq2lb	378	5	of	of	IN
cord-267897-w4pbq2lb	378	6	IL-6	IL-6	NNP
cord-267897-w4pbq2lb	378	7	after	after	IN
cord-267897-w4pbq2lb	378	8	administration	administration	NN
cord-267897-w4pbq2lb	378	9	of	of	IN
cord-267897-w4pbq2lb	378	10	LPS	LPS	NNP
cord-267897-w4pbq2lb	378	11	was	be	VBD
cord-267897-w4pbq2lb	378	12	reduced	reduce	VBN
cord-267897-w4pbq2lb	378	13	if	if	IN
cord-267897-w4pbq2lb	378	14	the	the	DT
cord-267897-w4pbq2lb	378	15	LPS	LPS	NNP
cord-267897-w4pbq2lb	378	16	was	be	VBD
cord-267897-w4pbq2lb	378	17	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	378	18	to	to	TO
cord-267897-w4pbq2lb	378	19	aluminum	aluminum	VB
cord-267897-w4pbq2lb	378	20	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	378	21	prior	prior	RB
cord-267897-w4pbq2lb	378	22	to	to	IN
cord-267897-w4pbq2lb	378	23	injection	injection	NN
cord-267897-w4pbq2lb	378	24	.	.	.
cord-267897-w4pbq2lb	379	1	122	122	CD
cord-267897-w4pbq2lb	379	2	Attempts	attempt	NNS
cord-267897-w4pbq2lb	379	3	have	have	VBP
cord-267897-w4pbq2lb	379	4	been	be	VBN
cord-267897-w4pbq2lb	379	5	made	make	VBN
cord-267897-w4pbq2lb	379	6	to	to	TO
cord-267897-w4pbq2lb	379	7	link	link	VB
cord-267897-w4pbq2lb	379	8	the	the	DT
cord-267897-w4pbq2lb	379	9	presence	presence	NN
cord-267897-w4pbq2lb	379	10	of	of	IN
cord-267897-w4pbq2lb	379	11	a	a	DT
cord-267897-w4pbq2lb	379	12	local	local	JJ
cord-267897-w4pbq2lb	379	13	inflammatory	inflammatory	JJ
cord-267897-w4pbq2lb	379	14	focus	focus	NN
cord-267897-w4pbq2lb	379	15	in	in	IN
cord-267897-w4pbq2lb	379	16	the	the	DT
cord-267897-w4pbq2lb	379	17	myofascii	myofascii	NNP
cord-267897-w4pbq2lb	379	18	(	(	-LRB-
cord-267897-w4pbq2lb	379	19	macrophagic	macrophagic	NNP
cord-267897-w4pbq2lb	379	20	myofasciitis	myofasciitis	NNP
cord-267897-w4pbq2lb	379	21	,	,	,
cord-267897-w4pbq2lb	379	22	MMF	MMF	NNP
cord-267897-w4pbq2lb	379	23	)	)	-RRB-
cord-267897-w4pbq2lb	379	24	after	after	IN
cord-267897-w4pbq2lb	379	25	IM	im	JJ
cord-267897-w4pbq2lb	379	26	injections	injection	NNS
cord-267897-w4pbq2lb	379	27	of	of	IN
cord-267897-w4pbq2lb	379	28	Al	Al	NNP
cord-267897-w4pbq2lb	379	29	-	-	HYPH
cord-267897-w4pbq2lb	379	30	adjuvanted	adjuvante	VBN
cord-267897-w4pbq2lb	379	31	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	379	32	to	to	IN
cord-267897-w4pbq2lb	379	33	conditions	condition	NNS
cord-267897-w4pbq2lb	379	34	,	,	,
cord-267897-w4pbq2lb	379	35	like	like	IN
cord-267897-w4pbq2lb	379	36	myalgia	myalgia	NN
cord-267897-w4pbq2lb	379	37	and	and	CC
cord-267897-w4pbq2lb	379	38	muscle	muscle	NN
cord-267897-w4pbq2lb	379	39	fatigue	fatigue	NN
cord-267897-w4pbq2lb	379	40	.	.	.
cord-267897-w4pbq2lb	380	1	Such	such	JJ
cord-267897-w4pbq2lb	380	2	manifestations	manifestation	NNS
cord-267897-w4pbq2lb	380	3	can	can	MD
cord-267897-w4pbq2lb	380	4	partly	partly	RB
cord-267897-w4pbq2lb	380	5	be	be	VB
cord-267897-w4pbq2lb	380	6	explained	explain	VBN
cord-267897-w4pbq2lb	380	7	by	by	IN
cord-267897-w4pbq2lb	380	8	the	the	DT
cord-267897-w4pbq2lb	380	9	formation	formation	NN
cord-267897-w4pbq2lb	380	10	of	of	IN
cord-267897-w4pbq2lb	380	11	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	380	12	granulomas	granuloma	NNS
cord-267897-w4pbq2lb	380	13	in	in	IN
cord-267897-w4pbq2lb	380	14	the	the	DT
cord-267897-w4pbq2lb	380	15	muscle	muscle	NN
cord-267897-w4pbq2lb	380	16	tissue	tissue	NN
cord-267897-w4pbq2lb	380	17	.	.	.
cord-267897-w4pbq2lb	381	1	However	however	RB
cord-267897-w4pbq2lb	381	2	,	,	,
cord-267897-w4pbq2lb	381	3	MMF	MMF	NNP
cord-267897-w4pbq2lb	381	4	was	be	VBD
cord-267897-w4pbq2lb	381	5	also	also	RB
cord-267897-w4pbq2lb	381	6	claimed	claim	VBN
cord-267897-w4pbq2lb	381	7	to	to	TO
cord-267897-w4pbq2lb	381	8	be	be	VB
cord-267897-w4pbq2lb	381	9	associated	associate	VBN
cord-267897-w4pbq2lb	381	10	with	with	IN
cord-267897-w4pbq2lb	381	11	neurological	neurological	JJ
cord-267897-w4pbq2lb	381	12	disorders	disorder	NNS
cord-267897-w4pbq2lb	381	13	having	have	VBG
cord-267897-w4pbq2lb	381	14	no	no	DT
cord-267897-w4pbq2lb	381	15	obvious	obvious	JJ
cord-267897-w4pbq2lb	381	16	etiologic	etiologic	JJ
cord-267897-w4pbq2lb	381	17	relation	relation	NN
cord-267897-w4pbq2lb	381	18	to	to	IN
cord-267897-w4pbq2lb	381	19	the	the	DT
cord-267897-w4pbq2lb	381	20	vaccination	vaccination	NN
cord-267897-w4pbq2lb	381	21	.	.	.
cord-267897-w4pbq2lb	382	1	124	124	CD
cord-267897-w4pbq2lb	383	1	However	however	RB
cord-267897-w4pbq2lb	383	2	,	,	,
cord-267897-w4pbq2lb	383	3	such	such	JJ
cord-267897-w4pbq2lb	383	4	correlations	correlation	NNS
cord-267897-w4pbq2lb	383	5	are	be	VBP
cord-267897-w4pbq2lb	383	6	associated	associate	VBN
cord-267897-w4pbq2lb	383	7	with	with	IN
cord-267897-w4pbq2lb	383	8	statistical	statistical	JJ
cord-267897-w4pbq2lb	383	9	challenges	challenge	NNS
cord-267897-w4pbq2lb	383	10	.	.	.
cord-267897-w4pbq2lb	384	1	Due	due	IN
cord-267897-w4pbq2lb	384	2	to	to	IN
cord-267897-w4pbq2lb	384	3	the	the	DT
cord-267897-w4pbq2lb	384	4	very	very	RB
cord-267897-w4pbq2lb	384	5	high	high	JJ
cord-267897-w4pbq2lb	384	6	vaccination	vaccination	NN
cord-267897-w4pbq2lb	384	7	coverage	coverage	NN
cord-267897-w4pbq2lb	384	8	in	in	IN
cord-267897-w4pbq2lb	384	9	the	the	DT
cord-267897-w4pbq2lb	384	10	Western	western	JJ
cord-267897-w4pbq2lb	384	11	countries	country	NNS
cord-267897-w4pbq2lb	384	12	,	,	,
cord-267897-w4pbq2lb	384	13	it	-PRON-	PRP
cord-267897-w4pbq2lb	384	14	is	be	VBZ
cord-267897-w4pbq2lb	384	15	expected	expect	VBN
cord-267897-w4pbq2lb	384	16	statistically	statistically	RB
cord-267897-w4pbq2lb	384	17	that	that	IN
cord-267897-w4pbq2lb	384	18	patients	patient	NNS
cord-267897-w4pbq2lb	384	19	suffering	suffer	VBG
cord-267897-w4pbq2lb	384	20	from	from	IN
cord-267897-w4pbq2lb	384	21	a	a	DT
cord-267897-w4pbq2lb	384	22	wide	wide	JJ
cord-267897-w4pbq2lb	384	23	range	range	NN
cord-267897-w4pbq2lb	384	24	of	of	IN
cord-267897-w4pbq2lb	384	25	unrelated	unrelated	JJ
cord-267897-w4pbq2lb	384	26	diseases	disease	NNS
cord-267897-w4pbq2lb	384	27	would	would	MD
cord-267897-w4pbq2lb	384	28	all	all	DT
cord-267897-w4pbq2lb	384	29	have	have	VB
cord-267897-w4pbq2lb	384	30	been	be	VBN
cord-267897-w4pbq2lb	384	31	vaccinated	vaccinate	VBN
cord-267897-w4pbq2lb	384	32	with	with	IN
cord-267897-w4pbq2lb	384	33	Al	Al	NNP
cord-267897-w4pbq2lb	384	34	-	-	HYPH
cord-267897-w4pbq2lb	384	35	containing	contain	VBG
cord-267897-w4pbq2lb	384	36	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	384	37	at	at	IN
cord-267897-w4pbq2lb	384	38	some	some	DT
cord-267897-w4pbq2lb	384	39	point	point	NN
cord-267897-w4pbq2lb	384	40	in	in	IN
cord-267897-w4pbq2lb	384	41	their	-PRON-	PRP$
cord-267897-w4pbq2lb	384	42	medical	medical	JJ
cord-267897-w4pbq2lb	384	43	history	history	NN
cord-267897-w4pbq2lb	384	44	.	.	.
cord-267897-w4pbq2lb	385	1	In	in	IN
cord-267897-w4pbq2lb	385	2	a	a	DT
cord-267897-w4pbq2lb	385	3	controlled	control	VBN
cord-267897-w4pbq2lb	385	4	study	study	NN
cord-267897-w4pbq2lb	385	5	in	in	IN
cord-267897-w4pbq2lb	385	6	cynomolgus	cynomolgus	JJ
cord-267897-w4pbq2lb	385	7	monkeys	monkey	NNS
cord-267897-w4pbq2lb	385	8	,	,	,
cord-267897-w4pbq2lb	385	9	it	-PRON-	PRP
cord-267897-w4pbq2lb	385	10	was	be	VBD
cord-267897-w4pbq2lb	385	11	not	not	RB
cord-267897-w4pbq2lb	385	12	possible	possible	JJ
cord-267897-w4pbq2lb	385	13	to	to	TO
cord-267897-w4pbq2lb	385	14	detect	detect	VB
cord-267897-w4pbq2lb	385	15	any	any	DT
cord-267897-w4pbq2lb	385	16	histological	histological	JJ
cord-267897-w4pbq2lb	385	17	changes	change	NNS
cord-267897-w4pbq2lb	385	18	besides	besides	IN
cord-267897-w4pbq2lb	385	19	the	the	DT
cord-267897-w4pbq2lb	385	20	local	local	JJ
cord-267897-w4pbq2lb	385	21	inflammatory	inflammatory	JJ
cord-267897-w4pbq2lb	385	22	focus	focus	NN
cord-267897-w4pbq2lb	385	23	itself	-PRON-	PRP
cord-267897-w4pbq2lb	385	24	and	and	CC
cord-267897-w4pbq2lb	386	1	no	no	DT
cord-267897-w4pbq2lb	386	2	abnormal	abnormal	JJ
cord-267897-w4pbq2lb	386	3	clinical	clinical	JJ
cord-267897-w4pbq2lb	386	4	signs	sign	NNS
cord-267897-w4pbq2lb	386	5	were	be	VBD
cord-267897-w4pbq2lb	386	6	associated	associate	VBN
cord-267897-w4pbq2lb	386	7	with	with	IN
cord-267897-w4pbq2lb	386	8	it	-PRON-	PRP
cord-267897-w4pbq2lb	386	9	.	.	.
cord-267897-w4pbq2lb	387	1	125	125	CD
cord-267897-w4pbq2lb	387	2	Vaccinations	vaccination	NNS
cord-267897-w4pbq2lb	387	3	may	may	MD
cord-267897-w4pbq2lb	387	4	be	be	VB
cord-267897-w4pbq2lb	387	5	given	give	VBN
cord-267897-w4pbq2lb	387	6	subcutaneously	subcutaneously	RB
cord-267897-w4pbq2lb	387	7	(	(	-LRB-
cord-267897-w4pbq2lb	387	8	SC	SC	NNP
cord-267897-w4pbq2lb	387	9	)	)	-RRB-
cord-267897-w4pbq2lb	387	10	or	or	CC
cord-267897-w4pbq2lb	387	11	IM	IM	NNP
cord-267897-w4pbq2lb	387	12	and	and	CC
cord-267897-w4pbq2lb	387	13	the	the	DT
cord-267897-w4pbq2lb	387	14	injection	injection	NN
cord-267897-w4pbq2lb	387	15	modus	modus	NN
cord-267897-w4pbq2lb	387	16	is	be	VBZ
cord-267897-w4pbq2lb	387	17	not	not	RB
cord-267897-w4pbq2lb	387	18	without	without	IN
cord-267897-w4pbq2lb	387	19	importance	importance	NN
cord-267897-w4pbq2lb	387	20	in	in	IN
cord-267897-w4pbq2lb	387	21	relation	relation	NN
cord-267897-w4pbq2lb	387	22	to	to	IN
cord-267897-w4pbq2lb	387	23	local	local	JJ
cord-267897-w4pbq2lb	387	24	reactogenicity	reactogenicity	NN
cord-267897-w4pbq2lb	387	25	.	.	.
cord-267897-w4pbq2lb	388	1	When	when	WRB
cord-267897-w4pbq2lb	388	2	immunizing	immunize	VBG
cord-267897-w4pbq2lb	388	3	by	by	IN
cord-267897-w4pbq2lb	388	4	the	the	DT
cord-267897-w4pbq2lb	388	5	SC	SC	NNP
cord-267897-w4pbq2lb	388	6	route	route	NN
cord-267897-w4pbq2lb	388	7	the	the	DT
cord-267897-w4pbq2lb	388	8	vaccine	vaccine	NN
cord-267897-w4pbq2lb	388	9	inoculum	inoculum	NN
cord-267897-w4pbq2lb	388	10	is	be	VBZ
cord-267897-w4pbq2lb	388	11	introduced	introduce	VBN
cord-267897-w4pbq2lb	388	12	into	into	IN
cord-267897-w4pbq2lb	388	13	a	a	DT
cord-267897-w4pbq2lb	388	14	compartment	compartment	NN
cord-267897-w4pbq2lb	388	15	with	with	IN
cord-267897-w4pbq2lb	388	16	numerous	numerous	JJ
cord-267897-w4pbq2lb	388	17	sensory	sensory	JJ
cord-267897-w4pbq2lb	388	18	neurons	neuron	NNS
cord-267897-w4pbq2lb	388	19	(	(	-LRB-
cord-267897-w4pbq2lb	388	20	in	in	IN
cord-267897-w4pbq2lb	388	21	contrast	contrast	NN
cord-267897-w4pbq2lb	388	22	to	to	IN
cord-267897-w4pbq2lb	388	23	the	the	DT
cord-267897-w4pbq2lb	388	24	IM	IM	NNP
cord-267897-w4pbq2lb	388	25	compartment	compartment	NN
cord-267897-w4pbq2lb	388	26	)	)	-RRB-
cord-267897-w4pbq2lb	388	27	.	.	.
cord-267897-w4pbq2lb	389	1	The	the	DT
cord-267897-w4pbq2lb	389	2	introduction	introduction	NN
cord-267897-w4pbq2lb	389	3	of	of	IN
cord-267897-w4pbq2lb	389	4	a	a	DT
cord-267897-w4pbq2lb	389	5	local	local	JJ
cord-267897-w4pbq2lb	389	6	inflammatory	inflammatory	JJ
cord-267897-w4pbq2lb	389	7	response	response	NN
cord-267897-w4pbq2lb	389	8	here	here	RB
cord-267897-w4pbq2lb	389	9	may	may	MD
cord-267897-w4pbq2lb	389	10	more	more	RBR
cord-267897-w4pbq2lb	389	11	easily	easily	RB
cord-267897-w4pbq2lb	389	12	lead	lead	VB
cord-267897-w4pbq2lb	389	13	to	to	IN
cord-267897-w4pbq2lb	389	14	irritation	irritation	NN
cord-267897-w4pbq2lb	389	15	and	and	CC
cord-267897-w4pbq2lb	389	16	itching	itching	NN
cord-267897-w4pbq2lb	389	17	reactions	reaction	NNS
cord-267897-w4pbq2lb	389	18	.	.	.
cord-267897-w4pbq2lb	390	1	Besides	besides	RB
cord-267897-w4pbq2lb	390	2	,	,	,
cord-267897-w4pbq2lb	390	3	a	a	DT
cord-267897-w4pbq2lb	390	4	transient	transient	JJ
cord-267897-w4pbq2lb	390	5	swelling	swelling	NN
cord-267897-w4pbq2lb	390	6	,	,	,
cord-267897-w4pbq2lb	390	7	as	as	IN
cord-267897-w4pbq2lb	390	8	a	a	DT
cord-267897-w4pbq2lb	390	9	consequence	consequence	NN
cord-267897-w4pbq2lb	390	10	of	of	IN
cord-267897-w4pbq2lb	390	11	the	the	DT
cord-267897-w4pbq2lb	390	12	inflammatory	inflammatory	JJ
cord-267897-w4pbq2lb	390	13	focus	focus	NN
cord-267897-w4pbq2lb	390	14	formed	form	VBN
cord-267897-w4pbq2lb	390	15	,	,	,
cord-267897-w4pbq2lb	390	16	may	may	MD
cord-267897-w4pbq2lb	390	17	more	more	RBR
cord-267897-w4pbq2lb	390	18	easily	easily	RB
cord-267897-w4pbq2lb	390	19	be	be	VB
cord-267897-w4pbq2lb	390	20	palpable	palpable	JJ
cord-267897-w4pbq2lb	390	21	through	through	IN
cord-267897-w4pbq2lb	390	22	the	the	DT
cord-267897-w4pbq2lb	390	23	skin	skin	NN
cord-267897-w4pbq2lb	390	24	.	.	.
cord-267897-w4pbq2lb	391	1	When	when	WRB
cord-267897-w4pbq2lb	391	2	immunizing	immunize	VBG
cord-267897-w4pbq2lb	391	3	by	by	IN
cord-267897-w4pbq2lb	391	4	the	the	DT
cord-267897-w4pbq2lb	391	5	IM	IM	NNP
cord-267897-w4pbq2lb	391	6	route	route	NN
cord-267897-w4pbq2lb	391	7	,	,	,
cord-267897-w4pbq2lb	391	8	even	even	RB
cord-267897-w4pbq2lb	391	9	a	a	DT
cord-267897-w4pbq2lb	391	10	similar	similar	JJ
cord-267897-w4pbq2lb	391	11	size	size	NN
cord-267897-w4pbq2lb	391	12	swelling	swelling	NN
cord-267897-w4pbq2lb	391	13	may	may	MD
cord-267897-w4pbq2lb	391	14	be	be	VB
cord-267897-w4pbq2lb	391	15	less	less	RBR
cord-267897-w4pbq2lb	391	16	easily	easily	RB
cord-267897-w4pbq2lb	391	17	visible	visible	JJ
cord-267897-w4pbq2lb	391	18	and	and	CC
cord-267897-w4pbq2lb	391	19	palpable	palpable	JJ
cord-267897-w4pbq2lb	391	20	as	as	IN
cord-267897-w4pbq2lb	391	21	it	-PRON-	PRP
cord-267897-w4pbq2lb	391	22	is	be	VBZ
cord-267897-w4pbq2lb	391	23	located	locate	VBN
cord-267897-w4pbq2lb	391	24	in	in	IN
cord-267897-w4pbq2lb	391	25	deeper	deep	JJR
cord-267897-w4pbq2lb	391	26	lying	lie	VBG
cord-267897-w4pbq2lb	391	27	tissue	tissue	NN
cord-267897-w4pbq2lb	391	28	.	.	.
cord-267897-w4pbq2lb	392	1	When	when	WRB
cord-267897-w4pbq2lb	392	2	evaluating	evaluate	VBG
cord-267897-w4pbq2lb	392	3	the	the	DT
cord-267897-w4pbq2lb	392	4	profile	profile	NN
cord-267897-w4pbq2lb	392	5	of	of	IN
cord-267897-w4pbq2lb	392	6	an	an	DT
cord-267897-w4pbq2lb	392	7	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	392	8	for	for	IN
cord-267897-w4pbq2lb	392	9	possible	possible	JJ
cord-267897-w4pbq2lb	392	10	new	new	JJ
cord-267897-w4pbq2lb	392	11	applications	application	NNS
cord-267897-w4pbq2lb	392	12	,	,	,
cord-267897-w4pbq2lb	392	13	very	very	RB
cord-267897-w4pbq2lb	392	14	few	few	JJ
cord-267897-w4pbq2lb	392	15	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	392	16	can	can	MD
cord-267897-w4pbq2lb	392	17	match	match	VB
cord-267897-w4pbq2lb	392	18	the	the	DT
cord-267897-w4pbq2lb	392	19	aluminum	aluminum	NN
cord-267897-w4pbq2lb	392	20	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	392	21	in	in	IN
cord-267897-w4pbq2lb	392	22	terms	term	NNS
cord-267897-w4pbq2lb	392	23	of	of	IN
cord-267897-w4pbq2lb	392	24	records	record	NNS
cord-267897-w4pbq2lb	392	25	of	of	IN
cord-267897-w4pbq2lb	392	26	efficacy	efficacy	NN
cord-267897-w4pbq2lb	392	27	and	and	CC
cord-267897-w4pbq2lb	392	28	safety	safety	NN
cord-267897-w4pbq2lb	392	29	profiles	profile	NNS
cord-267897-w4pbq2lb	392	30	from	from	IN
cord-267897-w4pbq2lb	392	31	a	a	DT
cord-267897-w4pbq2lb	392	32	period	period	NN
cord-267897-w4pbq2lb	392	33	of	of	IN
cord-267897-w4pbq2lb	392	34	use	use	NN
cord-267897-w4pbq2lb	392	35	reaching	reach	VBG
cord-267897-w4pbq2lb	392	36	practically	practically	RB
cord-267897-w4pbq2lb	392	37	over	over	IN
cord-267897-w4pbq2lb	392	38	an	an	DT
cord-267897-w4pbq2lb	392	39	entire	entire	JJ
cord-267897-w4pbq2lb	392	40	life	life	NN
cord-267897-w4pbq2lb	392	41	span	span	NN
cord-267897-w4pbq2lb	392	42	of	of	IN
cord-267897-w4pbq2lb	392	43	humans	human	NNS
cord-267897-w4pbq2lb	392	44	.	.	.
cord-267897-w4pbq2lb	393	1	The	the	DT
cord-267897-w4pbq2lb	393	2	aluminum	aluminum	NN
cord-267897-w4pbq2lb	393	3	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	393	4	have	have	VBP
cord-267897-w4pbq2lb	393	5	their	-PRON-	PRP$
cord-267897-w4pbq2lb	393	6	limitations	limitation	NNS
cord-267897-w4pbq2lb	393	7	,	,	,
cord-267897-w4pbq2lb	393	8	due	due	IN
cord-267897-w4pbq2lb	393	9	to	to	IN
cord-267897-w4pbq2lb	393	10	their	-PRON-	PRP$
cord-267897-w4pbq2lb	393	11	sensitivity	sensitivity	NN
cord-267897-w4pbq2lb	393	12	to	to	IN
cord-267897-w4pbq2lb	393	13	freezing	freezing	NN
cord-267897-w4pbq2lb	393	14	and	and	CC
cord-267897-w4pbq2lb	393	15	to	to	IN
cord-267897-w4pbq2lb	393	16	their	-PRON-	PRP$
cord-267897-w4pbq2lb	393	17	apparent	apparent	JJ
cord-267897-w4pbq2lb	393	18	Th2-biased	th2-biased	JJ
cord-267897-w4pbq2lb	393	19	profile	profile	NN
cord-267897-w4pbq2lb	393	20	.	.	.
cord-267897-w4pbq2lb	394	1	However	however	RB
cord-267897-w4pbq2lb	394	2	,	,	,
cord-267897-w4pbq2lb	394	3	it	-PRON-	PRP
cord-267897-w4pbq2lb	394	4	should	should	MD
cord-267897-w4pbq2lb	394	5	be	be	VB
cord-267897-w4pbq2lb	394	6	borne	bear	VBN
cord-267897-w4pbq2lb	394	7	in	in	IN
cord-267897-w4pbq2lb	394	8	mind	mind	NN
cord-267897-w4pbq2lb	395	1	that	that	IN
cord-267897-w4pbq2lb	395	2	most	most	JJS
cord-267897-w4pbq2lb	395	3	of	of	IN
cord-267897-w4pbq2lb	395	4	the	the	DT
cord-267897-w4pbq2lb	395	5	pioneering	pioneering	JJ
cord-267897-w4pbq2lb	395	6	work	work	NN
cord-267897-w4pbq2lb	395	7	that	that	WDT
cord-267897-w4pbq2lb	395	8	led	lead	VBD
cord-267897-w4pbq2lb	395	9	to	to	IN
cord-267897-w4pbq2lb	395	10	the	the	DT
cord-267897-w4pbq2lb	395	11	conclusion	conclusion	NN
cord-267897-w4pbq2lb	395	12	that	that	IN
cord-267897-w4pbq2lb	395	13	aluminum	aluminum	NN
cord-267897-w4pbq2lb	395	14	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	395	15	gave	give	VBD
cord-267897-w4pbq2lb	395	16	a	a	DT
cord-267897-w4pbq2lb	395	17	fairly	fairly	RB
cord-267897-w4pbq2lb	395	18	clear	clear	JJ
cord-267897-w4pbq2lb	395	19	Th2	th2	CD
cord-267897-w4pbq2lb	395	20	stimulation	stimulation	NN
cord-267897-w4pbq2lb	395	21	was	be	VBD
cord-267897-w4pbq2lb	395	22	carried	carry	VBN
cord-267897-w4pbq2lb	395	23	out	out	RP
cord-267897-w4pbq2lb	395	24	at	at	IN
cord-267897-w4pbq2lb	395	25	a	a	DT
cord-267897-w4pbq2lb	395	26	time	time	NN
cord-267897-w4pbq2lb	395	27	when	when	WRB
cord-267897-w4pbq2lb	395	28	only	only	RB
cord-267897-w4pbq2lb	395	29	the	the	DT
cord-267897-w4pbq2lb	395	30	Th1	th1	NN
cord-267897-w4pbq2lb	395	31	and	and	CC
cord-267897-w4pbq2lb	395	32	Th2	th2	CD
cord-267897-w4pbq2lb	395	33	subsets	subset	NNS
cord-267897-w4pbq2lb	395	34	were	be	VBD
cord-267897-w4pbq2lb	395	35	recognized	recognize	VBN
cord-267897-w4pbq2lb	395	36	.	.	.
cord-267897-w4pbq2lb	396	1	Since	since	IN
cord-267897-w4pbq2lb	396	2	then	then	RB
cord-267897-w4pbq2lb	396	3	another	another	DT
cord-267897-w4pbq2lb	396	4	three	three	CD
cord-267897-w4pbq2lb	396	5	effector	effector	NN
cord-267897-w4pbq2lb	396	6	T	t	NN
cord-267897-w4pbq2lb	396	7	-	-	HYPH
cord-267897-w4pbq2lb	396	8	cell	cell	NN
cord-267897-w4pbq2lb	396	9	subsets	subset	NNS
cord-267897-w4pbq2lb	396	10	have	have	VBP
cord-267897-w4pbq2lb	396	11	been	be	VBN
cord-267897-w4pbq2lb	396	12	identified	identify	VBN
cord-267897-w4pbq2lb	396	13	:	:	:
cord-267897-w4pbq2lb	396	14	Th17	th17	CD
cord-267897-w4pbq2lb	396	15	,	,	,
cord-267897-w4pbq2lb	396	16	regulatory	regulatory	JJ
cord-267897-w4pbq2lb	396	17	T	t	NN
cord-267897-w4pbq2lb	396	18	cells	cell	NNS
cord-267897-w4pbq2lb	396	19	,	,	,
cord-267897-w4pbq2lb	396	20	and	and	CC
cord-267897-w4pbq2lb	396	21	follicular	follicular	JJ
cord-267897-w4pbq2lb	396	22	T	t	NN
cord-267897-w4pbq2lb	396	23	-	-	HYPH
cord-267897-w4pbq2lb	396	24	helper	helper	NN
cord-267897-w4pbq2lb	396	25	cells	cell	NNS
cord-267897-w4pbq2lb	396	26	(	(	-LRB-
cord-267897-w4pbq2lb	396	27	T	T	NNP
cord-267897-w4pbq2lb	396	28	FH	FH	NNP
cord-267897-w4pbq2lb	396	29	)	)	-RRB-
cord-267897-w4pbq2lb	396	30	.	.	.
cord-267897-w4pbq2lb	397	1	Additional	additional	JJ
cord-267897-w4pbq2lb	397	2	research	research	NN
cord-267897-w4pbq2lb	397	3	is	be	VBZ
cord-267897-w4pbq2lb	397	4	required	require	VBN
cord-267897-w4pbq2lb	397	5	to	to	TO
cord-267897-w4pbq2lb	397	6	see	see	VB
cord-267897-w4pbq2lb	397	7	to	to	IN
cord-267897-w4pbq2lb	397	8	what	what	WDT
cord-267897-w4pbq2lb	397	9	extent	extent	NN
cord-267897-w4pbq2lb	397	10	,	,	,
cord-267897-w4pbq2lb	397	11	if	if	IN
cord-267897-w4pbq2lb	397	12	any	any	DT
cord-267897-w4pbq2lb	397	13	,	,	,
cord-267897-w4pbq2lb	397	14	aluminum	aluminum	NN
cord-267897-w4pbq2lb	397	15	-	-	HYPH
cord-267897-w4pbq2lb	397	16	or	or	CC
cord-267897-w4pbq2lb	397	17	calcium	calcium	NN
cord-267897-w4pbq2lb	397	18	-	-	HYPH
cord-267897-w4pbq2lb	397	19	based	base	VBN
cord-267897-w4pbq2lb	397	20	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	397	21	may	may	MD
cord-267897-w4pbq2lb	397	22	encompass	encompass	VB
cord-267897-w4pbq2lb	397	23	also	also	RB
cord-267897-w4pbq2lb	397	24	the	the	DT
cord-267897-w4pbq2lb	397	25	stimulation	stimulation	NN
cord-267897-w4pbq2lb	397	26	of	of	IN
cord-267897-w4pbq2lb	397	27	these	these	DT
cord-267897-w4pbq2lb	397	28	T	t	NN
cord-267897-w4pbq2lb	397	29	-	-	HYPH
cord-267897-w4pbq2lb	397	30	cell	cell	NN
cord-267897-w4pbq2lb	397	31	subsets	subset	NNS
cord-267897-w4pbq2lb	397	32	.	.	.
cord-267897-w4pbq2lb	398	1	Over	over	IN
cord-267897-w4pbq2lb	398	2	the	the	DT
cord-267897-w4pbq2lb	398	3	past	past	JJ
cord-267897-w4pbq2lb	398	4	20	20	CD
cord-267897-w4pbq2lb	398	5	years	year	NNS
cord-267897-w4pbq2lb	398	6	,	,	,
cord-267897-w4pbq2lb	398	7	there	there	EX
cord-267897-w4pbq2lb	398	8	has	have	VBZ
cord-267897-w4pbq2lb	398	9	been	be	VBN
cord-267897-w4pbq2lb	398	10	an	an	DT
cord-267897-w4pbq2lb	398	11	increasing	increase	VBG
cord-267897-w4pbq2lb	398	12	interest	interest	NN
cord-267897-w4pbq2lb	398	13	in	in	IN
cord-267897-w4pbq2lb	398	14	calcium	calcium	NN
cord-267897-w4pbq2lb	398	15	phosphate	phosphate	NN
cord-267897-w4pbq2lb	398	16	as	as	IN
cord-267897-w4pbq2lb	398	17	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	398	18	,	,	,
cord-267897-w4pbq2lb	398	19	not	not	RB
cord-267897-w4pbq2lb	398	20	only	only	RB
cord-267897-w4pbq2lb	398	21	for	for	IN
cord-267897-w4pbq2lb	398	22	conventional	conventional	JJ
cord-267897-w4pbq2lb	398	23	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	398	24	126	126	CD
cord-267897-w4pbq2lb	398	25	but	but	CC
cord-267897-w4pbq2lb	398	26	also	also	RB
cord-267897-w4pbq2lb	398	27	for	for	IN
cord-267897-w4pbq2lb	398	28	the	the	DT
cord-267897-w4pbq2lb	398	29	preparation	preparation	NN
cord-267897-w4pbq2lb	398	30	of	of	IN
cord-267897-w4pbq2lb	398	31	adsorbed	adsorbed	JJ
cord-267897-w4pbq2lb	398	32	allergens	allergen	NNS
cord-267897-w4pbq2lb	398	33	.	.	.
cord-267897-w4pbq2lb	399	1	Calcium	calcium	NN
cord-267897-w4pbq2lb	399	2	phosphate	phosphate	NN
cord-267897-w4pbq2lb	399	3	,	,	,
cord-267897-w4pbq2lb	399	4	being	be	VBG
cord-267897-w4pbq2lb	399	5	a	a	DT
cord-267897-w4pbq2lb	399	6	natural	natural	JJ
cord-267897-w4pbq2lb	399	7	constituent	constituent	NN
cord-267897-w4pbq2lb	399	8	of	of	IN
cord-267897-w4pbq2lb	399	9	the	the	DT
cord-267897-w4pbq2lb	399	10	body	body	NN
cord-267897-w4pbq2lb	399	11	and	and	CC
cord-267897-w4pbq2lb	399	12	hence	hence	RB
cord-267897-w4pbq2lb	399	13	fully	fully	RB
cord-267897-w4pbq2lb	399	14	physiologically	physiologically	RB
cord-267897-w4pbq2lb	399	15	compatible	compatible	JJ
cord-267897-w4pbq2lb	399	16	,	,	,
cord-267897-w4pbq2lb	399	17	constitutes	constitute	VBZ
cord-267897-w4pbq2lb	399	18	an	an	DT
cord-267897-w4pbq2lb	399	19	interesting	interesting	JJ
cord-267897-w4pbq2lb	399	20	alternative	alternative	NN
cord-267897-w4pbq2lb	399	21	to	to	IN
cord-267897-w4pbq2lb	399	22	the	the	DT
cord-267897-w4pbq2lb	399	23	aluminum	aluminum	NN
cord-267897-w4pbq2lb	399	24	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	399	25	not	not	RB
cord-267897-w4pbq2lb	399	26	yet	yet	RB
cord-267897-w4pbq2lb	399	27	fully	fully	RB
cord-267897-w4pbq2lb	399	28	explored	explore	VBN
cord-267897-w4pbq2lb	399	29	.	.	.
cord-267897-w4pbq2lb	399	30	 	 	_SP
cord-267897-w4pbq2lb	400	1	Immunological	immunological	JJ
cord-267897-w4pbq2lb	400	2	Adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	400	3	;	;	:
cord-267897-w4pbq2lb	400	4	1976	1976	CD
cord-267897-w4pbq2lb	400	5	.	.	.
cord-267897-w4pbq2lb	401	1	Technical	technical	JJ
cord-267897-w4pbq2lb	401	2	report	report	NN
cord-267897-w4pbq2lb	401	3	series	series	NN
cord-267897-w4pbq2lb	401	4	595	595	CD
cord-267897-w4pbq2lb	401	5	.	.	.
cord-267897-w4pbq2lb	402	1	World	World	NNP
cord-267897-w4pbq2lb	402	2	Health	Health	NNP
cord-267897-w4pbq2lb	402	3	Organization	Organization	NNP
cord-267897-w4pbq2lb	402	4	Vaccine	Vaccine	NNP
cord-267897-w4pbq2lb	402	5	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	403	1	Immunological	immunological	JJ
cord-267897-w4pbq2lb	403	2	notes	note	NNS
cord-267897-w4pbq2lb	403	3	XVII	XVII	NNP
cord-267897-w4pbq2lb	403	4	to	to	IN
cord-267897-w4pbq2lb	403	5	XXIV	XXIV	NNP
cord-267897-w4pbq2lb	403	6	Rate	rate	NN
cord-267897-w4pbq2lb	403	7	of	of	IN
cord-267897-w4pbq2lb	403	8	disappearance	disappearance	NN
cord-267897-w4pbq2lb	403	9	of	of	IN
cord-267897-w4pbq2lb	403	10	diphtheria	diphtheria	NN
cord-267897-w4pbq2lb	403	11	toxoid	toxoid	NN
cord-267897-w4pbq2lb	403	12	injected	inject	VBN
cord-267897-w4pbq2lb	403	13	into	into	IN
cord-267897-w4pbq2lb	403	14	rabbits	rabbit	NNS
cord-267897-w4pbq2lb	403	15	and	and	CC
cord-267897-w4pbq2lb	404	1	Guinea	guinea	NN
cord-267897-w4pbq2lb	404	2	-	-	HYPH
cord-267897-w4pbq2lb	404	3	Pigs	Pigs	NNP
cord-267897-w4pbq2lb	404	4	toxoid	toxoid	NN
cord-267897-w4pbq2lb	404	5	precipitated	precipitate	VBD
cord-267897-w4pbq2lb	404	6	with	with	IN
cord-267897-w4pbq2lb	404	7	alum	alum	NN
cord-267897-w4pbq2lb	404	8	Developments	development	NNS
cord-267897-w4pbq2lb	404	9	in	in	IN
cord-267897-w4pbq2lb	404	10	diphtheria	diphtheria	NN
cord-267897-w4pbq2lb	404	11	prophylaxis	prophylaxis	NN
cord-267897-w4pbq2lb	404	12	Uber	Uber	NNP
cord-267897-w4pbq2lb	404	13	die	die	VBP
cord-267897-w4pbq2lb	404	14	F€	F€	NNP
cord-267897-w4pbq2lb	404	15	ahigkeit	ahigkeit	RB
cord-267897-w4pbq2lb	405	1	des	des	NNP
cord-267897-w4pbq2lb	405	2	Tonerde	Tonerde	NNP
cord-267897-w4pbq2lb	405	3	-	-	HYPH
cord-267897-w4pbq2lb	405	4	Pr€	Pr€	NNP
cord-267897-w4pbq2lb	405	5	aparates	aparate	NNS
cord-267897-w4pbq2lb	405	6	B	b	NN
cord-267897-w4pbq2lb	405	7	,	,	,
cord-267897-w4pbq2lb	405	8	Diphtherie	Diphtherie	NNP
cord-267897-w4pbq2lb	405	9	-	-	HYPH
cord-267897-w4pbq2lb	405	10	Toxin	toxin	NN
cord-267897-w4pbq2lb	405	11	zu	zu	NNP
cord-267897-w4pbq2lb	405	12	adsorbieren	adsorbieren	NNP
cord-267897-w4pbq2lb	405	13	Diphtheria	Diphtheria	NNP
cord-267897-w4pbq2lb	405	14	immunization	immunization	NN
cord-267897-w4pbq2lb	405	15	with	with	IN
cord-267897-w4pbq2lb	405	16	fluid	fluid	JJ
cord-267897-w4pbq2lb	405	17	toxoid	toxoid	NN
cord-267897-w4pbq2lb	405	18	and	and	CC
cord-267897-w4pbq2lb	405	19	alum	alum	NN
cord-267897-w4pbq2lb	405	20	-	-	HYPH
cord-267897-w4pbq2lb	405	21	precipitated	precipitate	VBN
cord-267897-w4pbq2lb	405	22	toxoid	toxoid	NN
cord-267897-w4pbq2lb	405	23	Purification	purification	NN
cord-267897-w4pbq2lb	405	24	and	and	CC
cord-267897-w4pbq2lb	405	25	adsorption	adsorption	NN
cord-267897-w4pbq2lb	405	26	of	of	IN
cord-267897-w4pbq2lb	405	27	diphtheria	diphtheria	NN
cord-267897-w4pbq2lb	405	28	toxoid	toxoid	NN
cord-267897-w4pbq2lb	405	29	Purified	purify	VBN
cord-267897-w4pbq2lb	405	30	precipitated	precipitate	VBD
cord-267897-w4pbq2lb	405	31	diphtheria	diphtheria	NN
cord-267897-w4pbq2lb	405	32	toxoid	toxoid	NN
cord-267897-w4pbq2lb	405	33	of	of	IN
cord-267897-w4pbq2lb	405	34	constant	constant	JJ
cord-267897-w4pbq2lb	405	35	composition	composition	NN
cord-267897-w4pbq2lb	406	1	Uber	Uber	NNP
cord-267897-w4pbq2lb	406	2	ein	ein	NNP
cord-267897-w4pbq2lb	406	3	Tonerde	Tonerde	NNP
cord-267897-w4pbq2lb	406	4	-	-	HYPH
cord-267897-w4pbq2lb	406	5	Gel	Gel	NNP
cord-267897-w4pbq2lb	406	6	von	von	NNP
cord-267897-w4pbq2lb	406	7	der	der	NNP
cord-267897-w4pbq2lb	406	8	Formel	Formel	NNP
cord-267897-w4pbq2lb	406	9	Al	Al	NNP
cord-267897-w4pbq2lb	406	10	(	(	-LRB-
cord-267897-w4pbq2lb	406	11	OH	OH	NNP
cord-267897-w4pbq2lb	406	12	)	)	-RRB-
cord-267897-w4pbq2lb	406	13	3	3	CD
cord-267897-w4pbq2lb	406	14	.	.	.
cord-267897-w4pbq2lb	407	1	II	II	NNP
cord-267897-w4pbq2lb	407	2	.	.	.
cord-267897-w4pbq2lb	408	1	Mitteilung	Mitteilung	NNP
cord-267897-w4pbq2lb	408	2	€	€	CD
cord-267897-w4pbq2lb	409	1	uber	uber	NNP
cord-267897-w4pbq2lb	409	2	Hydrate	Hydrate	NNP
cord-267897-w4pbq2lb	409	3	und	und	IN
cord-267897-w4pbq2lb	409	4	Hydrogele	Hydrogele	NNP
cord-267897-w4pbq2lb	409	5	Uber	Uber	NNP
cord-267897-w4pbq2lb	409	6	die	die	NN
cord-267897-w4pbq2lb	409	7	Hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	410	1	und	und	IN
cord-267897-w4pbq2lb	410	2	ihre	ihre	NNP
cord-267897-w4pbq2lb	410	3	Hydrate	Hydrate	NNP
cord-267897-w4pbq2lb	410	4	in	in	IN
cord-267897-w4pbq2lb	410	5	den	den	NNP
cord-267897-w4pbq2lb	410	6	verschiedenen	verschiedenen	NNP
cord-267897-w4pbq2lb	410	7	Tonerde	Tonerde	NNP
cord-267897-w4pbq2lb	410	8	-	-	HYPH
cord-267897-w4pbq2lb	410	9	Gelen	Gelen	NNP
cord-267897-w4pbq2lb	410	10	Aluminium	Aluminium	NNP
cord-267897-w4pbq2lb	410	11	compounds	compound	NNS
cord-267897-w4pbq2lb	410	12	used	use	VBN
cord-267897-w4pbq2lb	410	13	as	as	IN
cord-267897-w4pbq2lb	410	14	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	410	15	in	in	IN
cord-267897-w4pbq2lb	410	16	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	410	17	Measuring	measure	VBG
cord-267897-w4pbq2lb	410	18	the	the	DT
cord-267897-w4pbq2lb	410	19	surface	surface	NN
cord-267897-w4pbq2lb	410	20	area	area	NN
cord-267897-w4pbq2lb	410	21	of	of	IN
cord-267897-w4pbq2lb	410	22	aluminium	aluminium	NN
cord-267897-w4pbq2lb	410	23	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	410	24	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	410	25	Structure	structure	NN
cord-267897-w4pbq2lb	410	26	and	and	CC
cord-267897-w4pbq2lb	410	27	adsorption	adsorption	NN
cord-267897-w4pbq2lb	410	28	properties	property	NNS
cord-267897-w4pbq2lb	410	29	of	of	IN
cord-267897-w4pbq2lb	410	30	commercial	commercial	JJ
cord-267897-w4pbq2lb	410	31	calcium	calcium	NN
cord-267897-w4pbq2lb	410	32	phosphate	phosphate	NN
cord-267897-w4pbq2lb	410	33	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	410	34	Avian	avian	JJ
cord-267897-w4pbq2lb	410	35	infectious	infectious	JJ
cord-267897-w4pbq2lb	410	36	bronchitis	bronchitis	NN
cord-267897-w4pbq2lb	410	37	:	:	:
cord-267897-w4pbq2lb	410	38	the	the	DT
cord-267897-w4pbq2lb	410	39	protection	protection	NN
cord-267897-w4pbq2lb	410	40	afforded	afford	VBN
cord-267897-w4pbq2lb	410	41	by	by	IN
cord-267897-w4pbq2lb	410	42	an	an	DT
cord-267897-w4pbq2lb	410	43	inactivated	inactivate	VBN
cord-267897-w4pbq2lb	410	44	virus	virus	NN
cord-267897-w4pbq2lb	410	45	vaccine	vaccine	NN
cord-267897-w4pbq2lb	410	46	Experiments	experiment	NNS
cord-267897-w4pbq2lb	410	47	with	with	IN
cord-267897-w4pbq2lb	410	48	an	an	DT
cord-267897-w4pbq2lb	410	49	inactivated	inactivate	VBN
cord-267897-w4pbq2lb	410	50	hepatitis	hepatitis	NN
cord-267897-w4pbq2lb	410	51	leptospirosis	leptospirosis	NN
cord-267897-w4pbq2lb	410	52	vaccine	vaccine	NN
cord-267897-w4pbq2lb	410	53	in	in	IN
cord-267897-w4pbq2lb	410	54	vaccination	vaccination	NN
cord-267897-w4pbq2lb	410	55	programmes	programme	NNS
cord-267897-w4pbq2lb	410	56	for	for	IN
cord-267897-w4pbq2lb	410	57	dogs	dog	NNS
cord-267897-w4pbq2lb	410	58	Early	early	JJ
cord-267897-w4pbq2lb	410	59	protection	protection	NN
cord-267897-w4pbq2lb	410	60	of	of	IN
cord-267897-w4pbq2lb	410	61	pigs	pig	NNS
cord-267897-w4pbq2lb	410	62	against	against	IN
cord-267897-w4pbq2lb	410	63	foot	foot	NN
cord-267897-w4pbq2lb	410	64	-	-	HYPH
cord-267897-w4pbq2lb	410	65	and	and	CC
cord-267897-w4pbq2lb	410	66	-	-	HYPH
cord-267897-w4pbq2lb	410	67	mouth	mouth	NN
cord-267897-w4pbq2lb	410	68	disease	disease	NN
cord-267897-w4pbq2lb	411	1	The	the	DT
cord-267897-w4pbq2lb	411	2	influence	influence	NN
cord-267897-w4pbq2lb	411	3	of	of	IN
cord-267897-w4pbq2lb	411	4	aluminium	aluminium	NN
cord-267897-w4pbq2lb	411	5	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	411	6	content	content	NN
cord-267897-w4pbq2lb	411	7	,	,	,
cord-267897-w4pbq2lb	411	8	dose	dose	JJ
cord-267897-w4pbq2lb	411	9	volume	volume	NN
cord-267897-w4pbq2lb	411	10	and	and	CC
cord-267897-w4pbq2lb	411	11	the	the	DT
cord-267897-w4pbq2lb	411	12	inclusion	inclusion	NN
cord-267897-w4pbq2lb	411	13	of	of	IN
cord-267897-w4pbq2lb	411	14	saponin	saponin	NN
cord-267897-w4pbq2lb	411	15	on	on	IN
cord-267897-w4pbq2lb	411	16	the	the	DT
cord-267897-w4pbq2lb	411	17	efficacy	efficacy	NN
cord-267897-w4pbq2lb	411	18	of	of	IN
cord-267897-w4pbq2lb	411	19	inactivated	inactivate	VBN
cord-267897-w4pbq2lb	411	20	foot	foot	NN
cord-267897-w4pbq2lb	411	21	-	-	HYPH
cord-267897-w4pbq2lb	411	22	and	and	CC
cord-267897-w4pbq2lb	411	23	-	-	HYPH
cord-267897-w4pbq2lb	411	24	mouth	mouth	NN
cord-267897-w4pbq2lb	411	25	disease	disease	NN
cord-267897-w4pbq2lb	411	26	vaccines	vaccine	VBZ
cord-267897-w4pbq2lb	411	27	Comparative	comparative	JJ
cord-267897-w4pbq2lb	411	28	evaluation	evaluation	NN
cord-267897-w4pbq2lb	411	29	of	of	IN
cord-267897-w4pbq2lb	411	30	the	the	DT
cord-267897-w4pbq2lb	411	31	potency	potency	NN
cord-267897-w4pbq2lb	411	32	of	of	IN
cord-267897-w4pbq2lb	411	33	beta	beta	NN
cord-267897-w4pbq2lb	411	34	-	-	HYPH
cord-267897-w4pbq2lb	411	35	propiolactone	propiolactone	NN
cord-267897-w4pbq2lb	411	36	inactivated	inactivate	VBD
cord-267897-w4pbq2lb	411	37	Newcastle	Newcastle	NNP
cord-267897-w4pbq2lb	411	38	disease	disease	NN
cord-267897-w4pbq2lb	411	39	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	411	40	prepared	prepare	VBN
cord-267897-w4pbq2lb	411	41	from	from	IN
cord-267897-w4pbq2lb	411	42	a	a	DT
cord-267897-w4pbq2lb	411	43	Lentogenic	Lentogenic	NNP
cord-267897-w4pbq2lb	411	44	and	and	CC
cord-267897-w4pbq2lb	411	45	a	a	DT
cord-267897-w4pbq2lb	411	46	Velogenic	Velogenic	NNP
cord-267897-w4pbq2lb	411	47	strain	strain	NN
cord-267897-w4pbq2lb	411	48	Comparison	comparison	NN
cord-267897-w4pbq2lb	411	49	of	of	IN
cord-267897-w4pbq2lb	411	50	alum	alum	NN
cord-267897-w4pbq2lb	411	51	-	-	HYPH
cord-267897-w4pbq2lb	411	52	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	411	53	or	or	CC
cord-267897-w4pbq2lb	411	54	non	non	JJ
cord-267897-w4pbq2lb	411	55	-	-	JJ
cord-267897-w4pbq2lb	411	56	alum	alum	JJ
cord-267897-w4pbq2lb	411	57	-	-	HYPH
cord-267897-w4pbq2lb	411	58	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	411	59	oil	oil	NN
cord-267897-w4pbq2lb	411	60	emulsion	emulsion	NN
cord-267897-w4pbq2lb	411	61	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	411	62	containing	contain	VBG
cord-267897-w4pbq2lb	411	63	,	,	,
cord-267897-w4pbq2lb	411	64	either	either	CC
cord-267897-w4pbq2lb	411	65	pilate	pilate	NNP
cord-267897-w4pbq2lb	411	66	or	or	CC
cord-267897-w4pbq2lb	411	67	non	non	NNP
cord-267897-w4pbq2lb	411	68	-	-	JJ
cord-267897-w4pbq2lb	411	69	pilate	pilate	NNP
cord-267897-w4pbq2lb	411	70	Bacteroides	Bacteroides	NNP
cord-267897-w4pbq2lb	411	71	nodosus	nodosus	NN
cord-267897-w4pbq2lb	411	72	cells	cell	NNS
cord-267897-w4pbq2lb	411	73	in	in	IN
cord-267897-w4pbq2lb	411	74	inducing	induce	VBG
cord-267897-w4pbq2lb	411	75	and	and	CC
cord-267897-w4pbq2lb	411	76	maintaining	maintain	VBG
cord-267897-w4pbq2lb	411	77	resistance	resistance	NN
cord-267897-w4pbq2lb	411	78	of	of	IN
cord-267897-w4pbq2lb	411	79	sheep	sheep	NN
cord-267897-w4pbq2lb	411	80	to	to	IN
cord-267897-w4pbq2lb	411	81	experimental	experimental	JJ
cord-267897-w4pbq2lb	411	82	foot	foot	NN
cord-267897-w4pbq2lb	411	83	rot	rot	VB
cord-267897-w4pbq2lb	411	84	Vaccination	vaccination	NN
cord-267897-w4pbq2lb	411	85	against	against	IN
cord-267897-w4pbq2lb	411	86	canine	canine	JJ
cord-267897-w4pbq2lb	411	87	Bordetellosis	Bordetellosis	NNP
cord-267897-w4pbq2lb	411	88	using	use	VBG
cord-267897-w4pbq2lb	411	89	an	an	DT
cord-267897-w4pbq2lb	411	90	aluminium	aluminium	NN
cord-267897-w4pbq2lb	411	91	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	411	92	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	411	93	vaccine	vaccine	NN
cord-267897-w4pbq2lb	411	94	Protective	protective	JJ
cord-267897-w4pbq2lb	411	95	antigens	antigen	NNS
cord-267897-w4pbq2lb	411	96	in	in	IN
cord-267897-w4pbq2lb	411	97	bovine	bovine	JJ
cord-267897-w4pbq2lb	411	98	Pasteurellosis	Pasteurellosis	NNP
cord-267897-w4pbq2lb	411	99	Leptospira	Leptospira	NNP
cord-267897-w4pbq2lb	411	100	interrogans	interrogan	NNS
cord-267897-w4pbq2lb	411	101	serovar	serovar	NNP
cord-267897-w4pbq2lb	411	102	.	.	.
cord-267897-w4pbq2lb	412	1	Pomona	Pomona	NNP
cord-267897-w4pbq2lb	412	2	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	412	3	with	with	IN
cord-267897-w4pbq2lb	412	4	different	different	JJ
cord-267897-w4pbq2lb	412	5	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	412	6	in	in	IN
cord-267897-w4pbq2lb	412	7	cattle	cattle	NNS
cord-267897-w4pbq2lb	412	8	Immunogenic	immunogenic	JJ
cord-267897-w4pbq2lb	412	9	effects	effect	NNS
cord-267897-w4pbq2lb	412	10	of	of	IN
cord-267897-w4pbq2lb	412	11	culture	culture	NN
cord-267897-w4pbq2lb	412	12	-	-	HYPH
cord-267897-w4pbq2lb	412	13	derived	derive	VBN
cord-267897-w4pbq2lb	412	14	exoantigens	exoantigen	NNS
cord-267897-w4pbq2lb	412	15	of	of	IN
cord-267897-w4pbq2lb	412	16	Cooperia	Cooperia	NNP
cord-267897-w4pbq2lb	412	17	punctata	punctata	NN
cord-267897-w4pbq2lb	412	18	on	on	IN
cord-267897-w4pbq2lb	412	19	calves	calf	NNS
cord-267897-w4pbq2lb	412	20	before	before	IN
cord-267897-w4pbq2lb	412	21	and	and	CC
cord-267897-w4pbq2lb	412	22	after	after	IN
cord-267897-w4pbq2lb	412	23	challenge	challenge	NN
cord-267897-w4pbq2lb	412	24	exposure	exposure	NN
cord-267897-w4pbq2lb	412	25	with	with	IN
cord-267897-w4pbq2lb	412	26	infective	infective	JJ
cord-267897-w4pbq2lb	412	27	larvae	larva	NNS
cord-267897-w4pbq2lb	412	28	Inocu1ation	inocu1ation	NN
cord-267897-w4pbq2lb	412	29	of	of	IN
cord-267897-w4pbq2lb	412	30	pigs	pig	NNS
cord-267897-w4pbq2lb	412	31	against	against	IN
cord-267897-w4pbq2lb	412	32	Trichinella	trichinella	NN
cord-267897-w4pbq2lb	412	33	spiralis	spirali	NNS
cord-267897-w4pbq2lb	412	34	using	use	VBG
cord-267897-w4pbq2lb	412	35	larval	larval	JJ
cord-267897-w4pbq2lb	412	36	excretory	excretory	JJ
cord-267897-w4pbq2lb	412	37	-	-	HYPH
cord-267897-w4pbq2lb	412	38	secretory	secretory	JJ
cord-267897-w4pbq2lb	412	39	antigens	antigen	NNS
cord-267897-w4pbq2lb	412	40	Resistance	Resistance	NNP
cord-267897-w4pbq2lb	412	41	of	of	IN
cord-267897-w4pbq2lb	412	42	Onchocerca	Onchocerca	NNP
cord-267897-w4pbq2lb	412	43	lienalis	lienalis	JJ
cord-267897-w4pbq2lb	412	44	microfilariae	microfilariae	NN
cord-267897-w4pbq2lb	412	45	in	in	IN
cord-267897-w4pbq2lb	412	46	mice	mouse	NNS
cord-267897-w4pbq2lb	412	47	conferred	confer	VBN
cord-267897-w4pbq2lb	412	48	by	by	IN
cord-267897-w4pbq2lb	412	49	egg	egg	NN
cord-267897-w4pbq2lb	412	50	antigens	antigen	NNS
cord-267897-w4pbq2lb	412	51	of	of	IN
cord-267897-w4pbq2lb	412	52	homologous	homologous	JJ
cord-267897-w4pbq2lb	412	53	and	and	CC
cord-267897-w4pbq2lb	412	54	heterologous	heterologous	JJ
cord-267897-w4pbq2lb	412	55	Onchocerca	Onchocerca	NNP
cord-267897-w4pbq2lb	412	56	species	species	NN
cord-267897-w4pbq2lb	412	57	Preparation	preparation	NN
cord-267897-w4pbq2lb	412	58	and	and	CC
cord-267897-w4pbq2lb	412	59	use	use	NN
cord-267897-w4pbq2lb	412	60	of	of	IN
cord-267897-w4pbq2lb	412	61	calcium	calcium	NN
cord-267897-w4pbq2lb	412	62	phosphate	phosphate	NN
cord-267897-w4pbq2lb	412	63	adsorbed	adsorb	VBD
cord-267897-w4pbq2lb	412	64	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	412	65	Simultaneous	simultaneous	JJ
cord-267897-w4pbq2lb	412	66	administration	administration	NN
cord-267897-w4pbq2lb	412	67	of	of	IN
cord-267897-w4pbq2lb	412	68	diphtheria	diphtheria	NN
cord-267897-w4pbq2lb	412	69	-	-	HYPH
cord-267897-w4pbq2lb	412	70	tetanus	tetanus	NN
cord-267897-w4pbq2lb	412	71	-	-	HYPH
cord-267897-w4pbq2lb	412	72	pertussis	pertussis	NN
cord-267897-w4pbq2lb	412	73	-	-	HYPH
cord-267897-w4pbq2lb	412	74	polio	polio	NN
cord-267897-w4pbq2lb	412	75	and	and	CC
cord-267897-w4pbq2lb	412	76	hepatitis	hepatitis	NN
cord-267897-w4pbq2lb	412	77	B	B	NNP
cord-267897-w4pbq2lb	412	78	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	412	79	in	in	IN
cord-267897-w4pbq2lb	412	80	a	a	DT
cord-267897-w4pbq2lb	412	81	simplified	simplified	JJ
cord-267897-w4pbq2lb	412	82	immunization	immunization	NN
cord-267897-w4pbq2lb	412	83	program	program	NN
cord-267897-w4pbq2lb	412	84	:	:	:
cord-267897-w4pbq2lb	412	85	immune	immune	JJ
cord-267897-w4pbq2lb	412	86	response	response	NN
cord-267897-w4pbq2lb	412	87	to	to	IN
cord-267897-w4pbq2lb	412	88	diphtheria	diphtheria	NN
cord-267897-w4pbq2lb	412	89	toxoid	toxoid	NN
cord-267897-w4pbq2lb	412	90	,	,	,
cord-267897-w4pbq2lb	412	91	tetanus	tetanus	NN
cord-267897-w4pbq2lb	412	92	toxoid	toxoid	NN
cord-267897-w4pbq2lb	412	93	,	,	,
cord-267897-w4pbq2lb	412	94	pertussis	pertussis	NN
cord-267897-w4pbq2lb	412	95	,	,	,
cord-267897-w4pbq2lb	412	96	and	and	CC
cord-267897-w4pbq2lb	412	97	hepatitis	hepatitis	NNP
cord-267897-w4pbq2lb	412	98	B	B	NNP
cord-267897-w4pbq2lb	412	99	surface	surface	NN
cord-267897-w4pbq2lb	412	100	antigen	antigen	NN
cord-267897-w4pbq2lb	412	101	Humoral	Humoral	NNP
cord-267897-w4pbq2lb	412	102	response	response	NN
cord-267897-w4pbq2lb	412	103	in	in	IN
cord-267897-w4pbq2lb	412	104	rabbits	rabbit	NNS
cord-267897-w4pbq2lb	412	105	immunized	immunize	VBN
cord-267897-w4pbq2lb	412	106	with	with	IN
cord-267897-w4pbq2lb	412	107	calcium	calcium	NN
cord-267897-w4pbq2lb	412	108	phosphate	phosphate	NN
cord-267897-w4pbq2lb	412	109	adjuvanted	adjuvante	VBD
cord-267897-w4pbq2lb	412	110	HIV-1	HIV-1	NNP
cord-267897-w4pbq2lb	412	111	gp160	gp160	NNP
cord-267897-w4pbq2lb	412	112	antigen	antigen	NN
cord-267897-w4pbq2lb	412	113	Calcium	Calcium	NNP
cord-267897-w4pbq2lb	412	114	phosphate	phosphate	NN
cord-267897-w4pbq2lb	412	115	adjuvanted	adjuvante	VBN
cord-267897-w4pbq2lb	412	116	allergens	allergen	NNS
cord-267897-w4pbq2lb	412	117	Adjuvant	Adjuvant	NNP
cord-267897-w4pbq2lb	412	118	modulation	modulation	NN
cord-267897-w4pbq2lb	412	119	of	of	IN
cord-267897-w4pbq2lb	412	120	immune	immune	JJ
cord-267897-w4pbq2lb	412	121	responses	response	NNS
cord-267897-w4pbq2lb	412	122	to	to	IN
cord-267897-w4pbq2lb	412	123	tuberculosis	tuberculosis	NN
cord-267897-w4pbq2lb	412	124	subunit	subunit	NN
cord-267897-w4pbq2lb	412	125	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	412	126	Validation	Validation	NNP
cord-267897-w4pbq2lb	412	127	of	of	IN
cord-267897-w4pbq2lb	412	128	the	the	DT
cord-267897-w4pbq2lb	412	129	shake	shake	NN
cord-267897-w4pbq2lb	412	130	test	test	NN
cord-267897-w4pbq2lb	412	131	for	for	IN
cord-267897-w4pbq2lb	412	132	detecting	detect	VBG
cord-267897-w4pbq2lb	412	133	freeze	freeze	NN
cord-267897-w4pbq2lb	412	134	damage	damage	NN
cord-267897-w4pbq2lb	412	135	to	to	IN
cord-267897-w4pbq2lb	412	136	adsorbed	adsorbed	JJ
cord-267897-w4pbq2lb	412	137	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	412	138	Structural	structural	JJ
cord-267897-w4pbq2lb	412	139	damages	damage	NNS
cord-267897-w4pbq2lb	412	140	in	in	IN
cord-267897-w4pbq2lb	412	141	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	412	142	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	412	143	affected	affect	VBN
cord-267897-w4pbq2lb	412	144	by	by	IN
cord-267897-w4pbq2lb	412	145	freezing	freeze	VBG
cord-267897-w4pbq2lb	412	146	Inhibition	inhibition	NN
cord-267897-w4pbq2lb	412	147	of	of	IN
cord-267897-w4pbq2lb	412	148	aggregation	aggregation	NN
cord-267897-w4pbq2lb	412	149	of	of	IN
cord-267897-w4pbq2lb	412	150	aluminum	aluminum	NN
cord-267897-w4pbq2lb	412	151	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	412	152	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	412	153	during	during	IN
cord-267897-w4pbq2lb	412	154	freezing	freeze	VBG
cord-267897-w4pbq2lb	412	155	and	and	CC
cord-267897-w4pbq2lb	412	156	drying	dry	VBG
cord-267897-w4pbq2lb	412	157	Stabilization	stabilization	NN
cord-267897-w4pbq2lb	412	158	of	of	IN
cord-267897-w4pbq2lb	412	159	a	a	DT
cord-267897-w4pbq2lb	412	160	recombinant	recombinant	JJ
cord-267897-w4pbq2lb	412	161	ricin	ricin	NN
cord-267897-w4pbq2lb	412	162	toxin	toxin	NN
cord-267897-w4pbq2lb	413	1	A	a	DT
cord-267897-w4pbq2lb	413	2	subunit	subunit	NN
cord-267897-w4pbq2lb	413	3	vaccine	vaccine	NN
cord-267897-w4pbq2lb	413	4	through	through	IN
cord-267897-w4pbq2lb	413	5	lyophilization	lyophilization	NN
cord-267897-w4pbq2lb	413	6	Lack	lack	NN
cord-267897-w4pbq2lb	413	7	of	of	IN
cord-267897-w4pbq2lb	413	8	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	413	9	effect	effect	NN
cord-267897-w4pbq2lb	413	10	of	of	IN
cord-267897-w4pbq2lb	413	11	AlPO	AlPO	NNP
cord-267897-w4pbq2lb	413	12	4	4	CD
cord-267897-w4pbq2lb	413	13	on	on	IN
cord-267897-w4pbq2lb	413	14	purified	purify	VBN
cord-267897-w4pbq2lb	413	15	influenza	influenza	NN
cord-267897-w4pbq2lb	413	16	virus	virus	NN
cord-267897-w4pbq2lb	413	17	Hemagglutinins	Hemagglutinins	NNP
cord-267897-w4pbq2lb	413	18	in	in	IN
cord-267897-w4pbq2lb	413	19	man	man	NN
cord-267897-w4pbq2lb	414	1	The	the	DT
cord-267897-w4pbq2lb	414	2	present	present	JJ
cord-267897-w4pbq2lb	414	3	status	status	NN
cord-267897-w4pbq2lb	414	4	of	of	IN
cord-267897-w4pbq2lb	414	5	field	field	NN
cord-267897-w4pbq2lb	414	6	and	and	CC
cord-267897-w4pbq2lb	414	7	laboratory	laboratory	NN
cord-267897-w4pbq2lb	414	8	studies	study	NNS
cord-267897-w4pbq2lb	414	9	of	of	IN
cord-267897-w4pbq2lb	414	10	typhoid	typhoid	NNP
cord-267897-w4pbq2lb	414	11	and	and	CC
cord-267897-w4pbq2lb	414	12	paratyphoid	paratyphoid	NNP
cord-267897-w4pbq2lb	414	13	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	415	1	Immune	immune	JJ
cord-267897-w4pbq2lb	415	2	response	response	NN
cord-267897-w4pbq2lb	415	3	to	to	IN
cord-267897-w4pbq2lb	415	4	uncoupled	uncoupled	JJ
cord-267897-w4pbq2lb	415	5	peptides	peptide	NNS
cord-267897-w4pbq2lb	415	6	of	of	IN
cord-267897-w4pbq2lb	415	7	foot	foot	NN
cord-267897-w4pbq2lb	415	8	-	-	HYPH
cord-267897-w4pbq2lb	415	9	and	and	CC
cord-267897-w4pbq2lb	415	10	-	-	HYPH
cord-267897-w4pbq2lb	415	11	mouth	mouth	NN
cord-267897-w4pbq2lb	415	12	disease	disease	NN
cord-267897-w4pbq2lb	415	13	virus	virus	NN
cord-267897-w4pbq2lb	415	14	Immunological	immunological	JJ
cord-267897-w4pbq2lb	415	15	priming	prime	VBG
cord-267897-w4pbq2lb	415	16	with	with	IN
cord-267897-w4pbq2lb	415	17	synthetic	synthetic	JJ
cord-267897-w4pbq2lb	415	18	peptides	peptide	NNS
cord-267897-w4pbq2lb	415	19	of	of	IN
cord-267897-w4pbq2lb	415	20	foot	foot	NN
cord-267897-w4pbq2lb	415	21	-	-	HYPH
cord-267897-w4pbq2lb	415	22	and	and	CC
cord-267897-w4pbq2lb	415	23	-	-	HYPH
cord-267897-w4pbq2lb	415	24	mouth	mouth	NN
cord-267897-w4pbq2lb	415	25	disease	disease	NN
cord-267897-w4pbq2lb	415	26	virus	virus	NN
cord-267897-w4pbq2lb	415	27	Comparison	comparison	NN
cord-267897-w4pbq2lb	415	28	of	of	IN
cord-267897-w4pbq2lb	415	29	antibody	antibody	NN
cord-267897-w4pbq2lb	415	30	avidity	avidity	NN
cord-267897-w4pbq2lb	415	31	and	and	CC
cord-267897-w4pbq2lb	415	32	titre	titre	NN
cord-267897-w4pbq2lb	415	33	elicited	elicit	VBN
cord-267897-w4pbq2lb	415	34	by	by	IN
cord-267897-w4pbq2lb	415	35	peptide	peptide	NN
cord-267897-w4pbq2lb	415	36	as	as	IN
cord-267897-w4pbq2lb	415	37	a	a	DT
cord-267897-w4pbq2lb	415	38	protein	protein	NN
cord-267897-w4pbq2lb	415	39	conjugate	conjugate	NN
cord-267897-w4pbq2lb	415	40	or	or	CC
cord-267897-w4pbq2lb	415	41	as	as	RB
cord-267897-w4pbq2lb	415	42	expressed	express	VBN
cord-267897-w4pbq2lb	415	43	in	in	IN
cord-267897-w4pbq2lb	415	44	vaccinia	vaccinia	NN
cord-267897-w4pbq2lb	416	1	The	the	DT
cord-267897-w4pbq2lb	416	2	influence	influence	NN
cord-267897-w4pbq2lb	416	3	of	of	IN
cord-267897-w4pbq2lb	416	4	different	different	JJ
cord-267897-w4pbq2lb	416	5	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	416	6	on	on	IN
cord-267897-w4pbq2lb	416	7	the	the	DT
cord-267897-w4pbq2lb	416	8	immune	immune	JJ
cord-267897-w4pbq2lb	416	9	response	response	NN
cord-267897-w4pbq2lb	416	10	to	to	IN
cord-267897-w4pbq2lb	416	11	a	a	DT
cord-267897-w4pbq2lb	416	12	synthetic	synthetic	JJ
cord-267897-w4pbq2lb	416	13	peptide	peptide	NN
cord-267897-w4pbq2lb	416	14	comprising	comprise	VBG
cord-267897-w4pbq2lb	416	15	amino	amino	NN
cord-267897-w4pbq2lb	416	16	acid	acid	NN
cord-267897-w4pbq2lb	416	17	residues	residue	NNS
cord-267897-w4pbq2lb	416	18	9	9	CD
cord-267897-w4pbq2lb	416	19	-	-	SYM
cord-267897-w4pbq2lb	416	20	21	21	CD
cord-267897-w4pbq2lb	416	21	of	of	IN
cord-267897-w4pbq2lb	416	22	herpes	herpes	NNP
cord-267897-w4pbq2lb	416	23	simplex	simplex	NNP
cord-267897-w4pbq2lb	416	24	virus	virus	NN
cord-267897-w4pbq2lb	416	25	type	type	NN
cord-267897-w4pbq2lb	416	26	1	1	CD
cord-267897-w4pbq2lb	416	27	Enhancement	Enhancement	NNP
cord-267897-w4pbq2lb	416	28	of	of	IN
cord-267897-w4pbq2lb	416	29	DNA	dna	NN
cord-267897-w4pbq2lb	416	30	vaccine	vaccine	NN
cord-267897-w4pbq2lb	416	31	potency	potency	NN
cord-267897-w4pbq2lb	416	32	using	use	VBG
cord-267897-w4pbq2lb	416	33	conventional	conventional	JJ
cord-267897-w4pbq2lb	416	34	aluminum	aluminum	NN
cord-267897-w4pbq2lb	416	35	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	416	36	Co	co	NN
cord-267897-w4pbq2lb	416	37	-	-	NN
cord-267897-w4pbq2lb	416	38	delivery	delivery	NN
cord-267897-w4pbq2lb	416	39	of	of	IN
cord-267897-w4pbq2lb	416	40	a	a	DT
cord-267897-w4pbq2lb	416	41	DNA	dna	NN
cord-267897-w4pbq2lb	416	42	vaccine	vaccine	NN
cord-267897-w4pbq2lb	416	43	and	and	CC
cord-267897-w4pbq2lb	416	44	a	a	DT
cord-267897-w4pbq2lb	416	45	protein	protein	NN
cord-267897-w4pbq2lb	416	46	vaccine	vaccine	NN
cord-267897-w4pbq2lb	416	47	with	with	IN
cord-267897-w4pbq2lb	416	48	aluminium	aluminium	NN
cord-267897-w4pbq2lb	416	49	phosphate	phosphate	NN
cord-267897-w4pbq2lb	416	50	stimulates	stimulate	VBZ
cord-267897-w4pbq2lb	416	51	a	a	DT
cord-267897-w4pbq2lb	416	52	potent	potent	JJ
cord-267897-w4pbq2lb	416	53	and	and	CC
cord-267897-w4pbq2lb	416	54	multivalent	multivalent	JJ
cord-267897-w4pbq2lb	416	55	immune	immune	JJ
cord-267897-w4pbq2lb	416	56	response	response	NN
cord-267897-w4pbq2lb	416	57	Influence	influence	NN
cord-267897-w4pbq2lb	416	58	of	of	IN
cord-267897-w4pbq2lb	416	59	elemental	elemental	JJ
cord-267897-w4pbq2lb	416	60	impurities	impurity	NNS
cord-267897-w4pbq2lb	416	61	in	in	IN
cord-267897-w4pbq2lb	416	62	aluminum	aluminum	NN
cord-267897-w4pbq2lb	416	63	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	416	64	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	416	65	on	on	IN
cord-267897-w4pbq2lb	416	66	the	the	DT
cord-267897-w4pbq2lb	416	67	stability	stability	NN
cord-267897-w4pbq2lb	416	68	of	of	IN
cord-267897-w4pbq2lb	416	69	inactivated	inactivate	VBN
cord-267897-w4pbq2lb	416	70	Japanese	japanese	JJ
cord-267897-w4pbq2lb	416	71	encephalitis	encephalitis	RB
cord-267897-w4pbq2lb	416	72	vaccine	vaccine	NN
cord-267897-w4pbq2lb	416	73	,	,	,
cord-267897-w4pbq2lb	416	74	IXIAROÒ	IXIAROÒ	NNP
cord-267897-w4pbq2lb	416	75	Vaccines	Vaccines	NNPS
cord-267897-w4pbq2lb	416	76	for	for	IN
cord-267897-w4pbq2lb	416	77	human	human	JJ
cord-267897-w4pbq2lb	416	78	use	use	NN
cord-267897-w4pbq2lb	416	79	Code	Code	NNP
cord-267897-w4pbq2lb	416	80	of	of	IN
cord-267897-w4pbq2lb	416	81	federal	federal	JJ
cord-267897-w4pbq2lb	416	82	regulations	regulation	NNS
cord-267897-w4pbq2lb	416	83	21	21	CD
cord-267897-w4pbq2lb	417	1	The	the	DT
cord-267897-w4pbq2lb	417	2	effect	effect	NN
cord-267897-w4pbq2lb	417	3	of	of	IN
cord-267897-w4pbq2lb	417	4	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	417	5	calcium	calcium	NN
cord-267897-w4pbq2lb	417	6	phosphate	phosphate	NN
cord-267897-w4pbq2lb	417	7	coating	coating	NN
cord-267897-w4pbq2lb	417	8	on	on	IN
cord-267897-w4pbq2lb	417	9	a	a	DT
cord-267897-w4pbq2lb	417	10	porous	porous	RB
cord-267897-w4pbq2lb	417	11	-	-	HYPH
cord-267897-w4pbq2lb	417	12	coated	coated	JJ
cord-267897-w4pbq2lb	417	13	femoral	femoral	JJ
cord-267897-w4pbq2lb	417	14	stem	stem	NN
cord-267897-w4pbq2lb	417	15	CpG	cpg	NN
cord-267897-w4pbq2lb	417	16	motifs	motif	NNS
cord-267897-w4pbq2lb	417	17	in	in	IN
cord-267897-w4pbq2lb	417	18	bacterial	bacterial	JJ
cord-267897-w4pbq2lb	417	19	DNA	dna	NN
cord-267897-w4pbq2lb	417	20	and	and	CC
cord-267897-w4pbq2lb	417	21	their	-PRON-	PRP$
cord-267897-w4pbq2lb	417	22	immune	immune	JJ
cord-267897-w4pbq2lb	417	23	effects	effect	NNS
cord-267897-w4pbq2lb	418	1	Immunopotentiating	immunopotentiate	VBG
cord-267897-w4pbq2lb	418	2	effects	effect	NNS
cord-267897-w4pbq2lb	418	3	of	of	IN
cord-267897-w4pbq2lb	418	4	the	the	DT
cord-267897-w4pbq2lb	418	5	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	418	6	SGP	SGP	NNP
cord-267897-w4pbq2lb	418	7	and	and	CC
cord-267897-w4pbq2lb	418	8	Quil	Quil	NNP
cord-267897-w4pbq2lb	418	9	-	-	HYPH
cord-267897-w4pbq2lb	418	10	A.	A.	NNP
cord-267897-w4pbq2lb	418	11	I.	I.	NNP
cord-267897-w4pbq2lb	418	12	Antibody	Antibody	NNP
cord-267897-w4pbq2lb	418	13	responses	response	NNS
cord-267897-w4pbq2lb	418	14	to	to	IN
cord-267897-w4pbq2lb	418	15	T	t	NN
cord-267897-w4pbq2lb	418	16	-	-	HYPH
cord-267897-w4pbq2lb	418	17	dependent	dependent	JJ
cord-267897-w4pbq2lb	418	18	and	and	CC
cord-267897-w4pbq2lb	418	19	T	t	NN
cord-267897-w4pbq2lb	418	20	-	-	HYPH
cord-267897-w4pbq2lb	418	21	independent	independent	JJ
cord-267897-w4pbq2lb	418	22	antigens	antigen	NNS
cord-267897-w4pbq2lb	418	23	Adjuvant	Adjuvant	NNP
cord-267897-w4pbq2lb	418	24	properties	property	NNS
cord-267897-w4pbq2lb	418	25	of	of	IN
cord-267897-w4pbq2lb	418	26	aluminum	aluminum	NN
cord-267897-w4pbq2lb	418	27	and	and	CC
cord-267897-w4pbq2lb	418	28	calcium	calcium	NN
cord-267897-w4pbq2lb	418	29	Modulation	modulation	NN
cord-267897-w4pbq2lb	418	30	of	of	IN
cord-267897-w4pbq2lb	418	31	the	the	DT
cord-267897-w4pbq2lb	418	32	human	human	JJ
cord-267897-w4pbq2lb	418	33	immune	immune	JJ
cord-267897-w4pbq2lb	418	34	response	response	NN
cord-267897-w4pbq2lb	418	35	by	by	IN
cord-267897-w4pbq2lb	418	36	the	the	DT
cord-267897-w4pbq2lb	418	37	non	non	JJ
cord-267897-w4pbq2lb	418	38	-	-	JJ
cord-267897-w4pbq2lb	418	39	toxic	toxic	JJ
cord-267897-w4pbq2lb	418	40	and	and	CC
cord-267897-w4pbq2lb	418	41	non	non	JJ
cord-267897-w4pbq2lb	418	42	-	-	JJ
cord-267897-w4pbq2lb	418	43	pyrogenic	pyrogenic	JJ
cord-267897-w4pbq2lb	418	44	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	418	45	aluminium	aluminium	NN
cord-267897-w4pbq2lb	418	46	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	418	47	:	:	:
cord-267897-w4pbq2lb	418	48	effect	effect	NN
cord-267897-w4pbq2lb	418	49	on	on	IN
cord-267897-w4pbq2lb	418	50	antigen	antigen	NN
cord-267897-w4pbq2lb	418	51	uptake	uptake	NN
cord-267897-w4pbq2lb	418	52	and	and	CC
cord-267897-w4pbq2lb	418	53	antigen	antigen	NN
cord-267897-w4pbq2lb	418	54	presentation	presentation	NN
cord-267897-w4pbq2lb	418	55	Characterization	characterization	NN
cord-267897-w4pbq2lb	418	56	of	of	IN
cord-267897-w4pbq2lb	418	57	aluminium	aluminium	NN
cord-267897-w4pbq2lb	418	58	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	418	59	for	for	IN
cord-267897-w4pbq2lb	418	60	use	use	NN
cord-267897-w4pbq2lb	418	61	as	as	IN
cord-267897-w4pbq2lb	418	62	an	an	DT
cord-267897-w4pbq2lb	418	63	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	418	64	in	in	IN
cord-267897-w4pbq2lb	418	65	parenteral	parenteral	JJ
cord-267897-w4pbq2lb	418	66	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	418	67	Contribution	Contribution	NNP
cord-267897-w4pbq2lb	418	68	of	of	IN
cord-267897-w4pbq2lb	418	69	electrostatic	electrostatic	JJ
cord-267897-w4pbq2lb	418	70	and	and	CC
cord-267897-w4pbq2lb	418	71	hydrophobic	hydrophobic	JJ
cord-267897-w4pbq2lb	418	72	interactions	interaction	NNS
cord-267897-w4pbq2lb	418	73	to	to	IN
cord-267897-w4pbq2lb	418	74	the	the	DT
cord-267897-w4pbq2lb	418	75	adsorption	adsorption	NN
cord-267897-w4pbq2lb	418	76	of	of	IN
cord-267897-w4pbq2lb	418	77	proteins	protein	NNS
cord-267897-w4pbq2lb	418	78	by	by	IN
cord-267897-w4pbq2lb	418	79	aluminium	aluminium	NN
cord-267897-w4pbq2lb	418	80	-	-	HYPH
cord-267897-w4pbq2lb	418	81	containing	contain	VBG
cord-267897-w4pbq2lb	418	82	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	418	83	Effect	effect	NN
cord-267897-w4pbq2lb	418	84	of	of	IN
cord-267897-w4pbq2lb	418	85	anions	anion	NNS
cord-267897-w4pbq2lb	418	86	on	on	IN
cord-267897-w4pbq2lb	418	87	model	model	NN
cord-267897-w4pbq2lb	418	88	aluminium	aluminium	NN
cord-267897-w4pbq2lb	418	89	-	-	HYPH
cord-267897-w4pbq2lb	418	90	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	418	91	-	-	HYPH
cord-267897-w4pbq2lb	418	92	containing	contain	VBG
cord-267897-w4pbq2lb	418	93	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	418	94	Elutability	Elutability	NNP
cord-267897-w4pbq2lb	418	95	of	of	IN
cord-267897-w4pbq2lb	418	96	proteins	protein	NNS
cord-267897-w4pbq2lb	418	97	from	from	IN
cord-267897-w4pbq2lb	418	98	aluminium	aluminium	NN
cord-267897-w4pbq2lb	418	99	-	-	HYPH
cord-267897-w4pbq2lb	418	100	containing	contain	VBG
cord-267897-w4pbq2lb	418	101	vaccine	vaccine	NN
cord-267897-w4pbq2lb	418	102	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	418	103	by	by	IN
cord-267897-w4pbq2lb	418	104	treatment	treatment	NN
cord-267897-w4pbq2lb	418	105	with	with	IN
cord-267897-w4pbq2lb	418	106	surfactants	surfactant	NNS
cord-267897-w4pbq2lb	418	107	Effect	Effect	NNP
cord-267897-w4pbq2lb	418	108	of	of	IN
cord-267897-w4pbq2lb	418	109	pH	pH	NNP
cord-267897-w4pbq2lb	418	110	on	on	IN
cord-267897-w4pbq2lb	418	111	the	the	DT
cord-267897-w4pbq2lb	418	112	elution	elution	NN
cord-267897-w4pbq2lb	418	113	of	of	IN
cord-267897-w4pbq2lb	418	114	model	model	NN
cord-267897-w4pbq2lb	418	115	antigens	antigen	NNS
cord-267897-w4pbq2lb	418	116	from	from	IN
cord-267897-w4pbq2lb	418	117	aluminiumcontaining	aluminiumcontaine	VBG
cord-267897-w4pbq2lb	418	118	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	418	119	Predicting	predict	VBG
cord-267897-w4pbq2lb	418	120	the	the	DT
cord-267897-w4pbq2lb	418	121	adsorption	adsorption	NN
cord-267897-w4pbq2lb	418	122	of	of	IN
cord-267897-w4pbq2lb	418	123	proteins	protein	NNS
cord-267897-w4pbq2lb	418	124	by	by	IN
cord-267897-w4pbq2lb	418	125	aluminium	aluminium	NN
cord-267897-w4pbq2lb	418	126	-	-	HYPH
cord-267897-w4pbq2lb	418	127	containing	contain	VBG
cord-267897-w4pbq2lb	418	128	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	418	129	A	a	DT
cord-267897-w4pbq2lb	418	130	novel	novel	JJ
cord-267897-w4pbq2lb	418	131	bipolar	bipolar	JJ
cord-267897-w4pbq2lb	418	132	mode	mode	NN
cord-267897-w4pbq2lb	418	133	of	of	IN
cord-267897-w4pbq2lb	418	134	attachment	attachment	NN
cord-267897-w4pbq2lb	418	135	to	to	IN
cord-267897-w4pbq2lb	418	136	aluminium	aluminium	NN
cord-267897-w4pbq2lb	418	137	-	-	HYPH
cord-267897-w4pbq2lb	418	138	containing	contain	VBG
cord-267897-w4pbq2lb	418	139	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	418	140	by	by	IN
cord-267897-w4pbq2lb	418	141	BBG2Na	BBG2Na	NNP
cord-267897-w4pbq2lb	418	142	,	,	,
cord-267897-w4pbq2lb	418	143	a	a	DT
cord-267897-w4pbq2lb	418	144	recombinant	recombinant	JJ
cord-267897-w4pbq2lb	418	145	subunit	subunit	NN
cord-267897-w4pbq2lb	418	146	hRSV	hrsv	NN
cord-267897-w4pbq2lb	418	147	vaccine	vaccine	NN
cord-267897-w4pbq2lb	418	148	Mechanism	Mechanism	NNP
cord-267897-w4pbq2lb	418	149	of	of	IN
cord-267897-w4pbq2lb	418	150	adsorption	adsorption	NN
cord-267897-w4pbq2lb	418	151	of	of	IN
cord-267897-w4pbq2lb	418	152	hepatitis	hepatitis	NNP
cord-267897-w4pbq2lb	418	153	B	B	NNP
cord-267897-w4pbq2lb	418	154	surface	surface	NN
cord-267897-w4pbq2lb	418	155	antigen	antigen	NN
cord-267897-w4pbq2lb	418	156	by	by	IN
cord-267897-w4pbq2lb	418	157	aluminium	aluminium	NN
cord-267897-w4pbq2lb	418	158	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	418	159	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	418	160	Effect	effect	NN
cord-267897-w4pbq2lb	418	161	of	of	IN
cord-267897-w4pbq2lb	418	162	the	the	DT
cord-267897-w4pbq2lb	418	163	degree	degree	NN
cord-267897-w4pbq2lb	418	164	of	of	IN
cord-267897-w4pbq2lb	418	165	phosphate	phosphate	NN
cord-267897-w4pbq2lb	418	166	substitution	substitution	NN
cord-267897-w4pbq2lb	418	167	in	in	IN
cord-267897-w4pbq2lb	418	168	aluminium	aluminium	NN
cord-267897-w4pbq2lb	418	169	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	418	170	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	418	171	on	on	IN
cord-267897-w4pbq2lb	418	172	the	the	DT
cord-267897-w4pbq2lb	418	173	adsorption	adsorption	NN
cord-267897-w4pbq2lb	418	174	of	of	IN
cord-267897-w4pbq2lb	418	175	phosphorylated	phosphorylated	JJ
cord-267897-w4pbq2lb	418	176	proteins	protein	NNS
cord-267897-w4pbq2lb	419	1	The	the	DT
cord-267897-w4pbq2lb	419	2	adsorption	adsorption	NN
cord-267897-w4pbq2lb	419	3	of	of	IN
cord-267897-w4pbq2lb	419	4	serum	serum	NN
cord-267897-w4pbq2lb	419	5	proteins	protein	NNS
cord-267897-w4pbq2lb	419	6	to	to	IN
cord-267897-w4pbq2lb	419	7	aluminium	aluminium	NN
cord-267897-w4pbq2lb	419	8	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	419	9	gel	gel	NN
cord-267897-w4pbq2lb	419	10	examined	examine	VBN
cord-267897-w4pbq2lb	419	11	by	by	IN
cord-267897-w4pbq2lb	419	12	means	mean	NNS
cord-267897-w4pbq2lb	419	13	of	of	IN
cord-267897-w4pbq2lb	419	14	quantitative	quantitative	JJ
cord-267897-w4pbq2lb	419	15	immunoelectrophoresis	immunoelectrophoresis	NN
cord-267897-w4pbq2lb	420	1	The	the	DT
cord-267897-w4pbq2lb	420	2	theory	theory	NN
cord-267897-w4pbq2lb	420	3	and	and	CC
cord-267897-w4pbq2lb	420	4	practical	practical	JJ
cord-267897-w4pbq2lb	420	5	application	application	NN
cord-267897-w4pbq2lb	420	6	of	of	IN
cord-267897-w4pbq2lb	420	7	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	420	8	Measurement	Measurement	NNP
cord-267897-w4pbq2lb	420	9	of	of	IN
cord-267897-w4pbq2lb	420	10	protein	protein	NN
cord-267897-w4pbq2lb	420	11	using	use	VBG
cord-267897-w4pbq2lb	420	12	bicinchoninic	bicinchoninic	NNP
cord-267897-w4pbq2lb	420	13	acid	acid	NN
cord-267897-w4pbq2lb	420	14	An	an	DT
cord-267897-w4pbq2lb	420	15	enzyme	enzyme	NN
cord-267897-w4pbq2lb	420	16	-	-	HYPH
cord-267897-w4pbq2lb	420	17	linked	link	VBN
cord-267897-w4pbq2lb	420	18	immunosorbent	immunosorbent	JJ
cord-267897-w4pbq2lb	420	19	assay	assay	NN
cord-267897-w4pbq2lb	420	20	for	for	IN
cord-267897-w4pbq2lb	420	21	the	the	DT
cord-267897-w4pbq2lb	420	22	detection	detection	NN
cord-267897-w4pbq2lb	420	23	of	of	IN
cord-267897-w4pbq2lb	420	24	antitetanus	antitetanus	NNP
cord-267897-w4pbq2lb	420	25	toxoid	toxoid	NN
cord-267897-w4pbq2lb	420	26	antibody	antibody	NN
cord-267897-w4pbq2lb	420	27	using	use	VBG
cord-267897-w4pbq2lb	420	28	aluminium	aluminium	NN
cord-267897-w4pbq2lb	420	29	-	-	HYPH
cord-267897-w4pbq2lb	420	30	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	420	31	coating	coating	NN
cord-267897-w4pbq2lb	420	32	antigen	antigen	NN
cord-267897-w4pbq2lb	421	1	In	in	IN
cord-267897-w4pbq2lb	421	2	vitro	vitro	FW
cord-267897-w4pbq2lb	421	3	assessment	assessment	NN
cord-267897-w4pbq2lb	421	4	of	of	IN
cord-267897-w4pbq2lb	421	5	viral	viral	JJ
cord-267897-w4pbq2lb	421	6	antigen	antigen	NN
cord-267897-w4pbq2lb	421	7	content	content	NN
cord-267897-w4pbq2lb	421	8	in	in	IN
cord-267897-w4pbq2lb	421	9	inactivated	inactivate	VBN
cord-267897-w4pbq2lb	421	10	aluminium	aluminium	NN
cord-267897-w4pbq2lb	421	11	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	421	12	adjuvanted	adjuvante	VBN
cord-267897-w4pbq2lb	422	1	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	422	2	Relationship	relationship	NN
cord-267897-w4pbq2lb	422	3	between	between	IN
cord-267897-w4pbq2lb	422	4	the	the	DT
cord-267897-w4pbq2lb	422	5	strength	strength	NN
cord-267897-w4pbq2lb	422	6	of	of	IN
cord-267897-w4pbq2lb	422	7	antigen	antigen	NN
cord-267897-w4pbq2lb	422	8	adsorption	adsorption	NN
cord-267897-w4pbq2lb	422	9	to	to	IN
cord-267897-w4pbq2lb	422	10	an	an	DT
cord-267897-w4pbq2lb	422	11	aluminum	aluminum	NN
cord-267897-w4pbq2lb	422	12	-	-	HYPH
cord-267897-w4pbq2lb	422	13	containing	contain	VBG
cord-267897-w4pbq2lb	422	14	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	422	15	and	and	CC
cord-267897-w4pbq2lb	422	16	the	the	DT
cord-267897-w4pbq2lb	422	17	immune	immune	JJ
cord-267897-w4pbq2lb	422	18	response	response	NN
cord-267897-w4pbq2lb	422	19	Effect	effect	NN
cord-267897-w4pbq2lb	422	20	of	of	IN
cord-267897-w4pbq2lb	422	21	the	the	DT
cord-267897-w4pbq2lb	422	22	strength	strength	NN
cord-267897-w4pbq2lb	422	23	of	of	IN
cord-267897-w4pbq2lb	422	24	adsorption	adsorption	NN
cord-267897-w4pbq2lb	422	25	of	of	IN
cord-267897-w4pbq2lb	422	26	hepatitis	hepatitis	NNP
cord-267897-w4pbq2lb	422	27	B	B	NNP
cord-267897-w4pbq2lb	422	28	surface	surface	NN
cord-267897-w4pbq2lb	422	29	antigen	antigen	NN
cord-267897-w4pbq2lb	422	30	to	to	IN
cord-267897-w4pbq2lb	422	31	aluminum	aluminum	NN
cord-267897-w4pbq2lb	422	32	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	422	33	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	422	34	on	on	IN
cord-267897-w4pbq2lb	422	35	the	the	DT
cord-267897-w4pbq2lb	422	36	immune	immune	JJ
cord-267897-w4pbq2lb	422	37	response	response	NN
cord-267897-w4pbq2lb	422	38	Effect	effect	NN
cord-267897-w4pbq2lb	422	39	of	of	IN
cord-267897-w4pbq2lb	422	40	the	the	DT
cord-267897-w4pbq2lb	422	41	strength	strength	NN
cord-267897-w4pbq2lb	422	42	of	of	IN
cord-267897-w4pbq2lb	422	43	adsorption	adsorption	NN
cord-267897-w4pbq2lb	422	44	of	of	IN
cord-267897-w4pbq2lb	422	45	HIV	HIV	NNP
cord-267897-w4pbq2lb	422	46	1	1	CD
cord-267897-w4pbq2lb	422	47	SF162dV2gp140	SF162dV2gp140	NNP
cord-267897-w4pbq2lb	422	48	to	to	TO
cord-267897-w4pbq2lb	422	49	aluminum	aluminum	NN
cord-267897-w4pbq2lb	422	50	-	-	HYPH
cord-267897-w4pbq2lb	422	51	containing	contain	VBG
cord-267897-w4pbq2lb	422	52	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	422	53	on	on	IN
cord-267897-w4pbq2lb	422	54	the	the	DT
cord-267897-w4pbq2lb	422	55	immune	immune	JJ
cord-267897-w4pbq2lb	422	56	response	response	NN
cord-267897-w4pbq2lb	423	1	The	the	DT
cord-267897-w4pbq2lb	423	2	constitution	constitution	NN
cord-267897-w4pbq2lb	423	3	and	and	CC
cord-267897-w4pbq2lb	423	4	fundamental	fundamental	JJ
cord-267897-w4pbq2lb	423	5	properties	property	NNS
cord-267897-w4pbq2lb	423	6	of	of	IN
cord-267897-w4pbq2lb	423	7	solids	solid	NNS
cord-267897-w4pbq2lb	423	8	and	and	CC
cord-267897-w4pbq2lb	423	9	liquids	liquid	NNS
cord-267897-w4pbq2lb	424	1	The	the	DT
cord-267897-w4pbq2lb	424	2	Langmuir	Langmuir	NNP
cord-267897-w4pbq2lb	424	3	isotherm	isotherm	NN
cord-267897-w4pbq2lb	424	4	:	:	:
cord-267897-w4pbq2lb	424	5	a	a	DT
cord-267897-w4pbq2lb	424	6	commonly	commonly	RB
cord-267897-w4pbq2lb	424	7	applied	apply	VBN
cord-267897-w4pbq2lb	424	8	but	but	CC
cord-267897-w4pbq2lb	424	9	misleading	misleading	JJ
cord-267897-w4pbq2lb	424	10	approach	approach	NN
cord-267897-w4pbq2lb	424	11	for	for	IN
cord-267897-w4pbq2lb	424	12	the	the	DT
cord-267897-w4pbq2lb	424	13	analysis	analysis	NN
cord-267897-w4pbq2lb	424	14	of	of	IN
cord-267897-w4pbq2lb	424	15	protein	protein	NN
cord-267897-w4pbq2lb	424	16	adsorption	adsorption	NN
cord-267897-w4pbq2lb	424	17	behavior	behavior	NN
cord-267897-w4pbq2lb	424	18	Over	over	IN
cord-267897-w4pbq2lb	424	19	the	the	DT
cord-267897-w4pbq2lb	424	20	adsorption	adsorption	NN
cord-267897-w4pbq2lb	424	21	in	in	IN
cord-267897-w4pbq2lb	424	22	solution	solution	NN
cord-267897-w4pbq2lb	424	23	State	state	NN
cord-267897-w4pbq2lb	424	24	equations	equation	NNS
cord-267897-w4pbq2lb	424	25	of	of	IN
cord-267897-w4pbq2lb	424	26	the	the	DT
cord-267897-w4pbq2lb	424	27	solid	solid	JJ
cord-267897-w4pbq2lb	424	28	gas	gas	NN
cord-267897-w4pbq2lb	424	29	interface	interface	NN
cord-267897-w4pbq2lb	424	30	layer	layer	NN
cord-267897-w4pbq2lb	424	31	Insights	insight	NNS
cord-267897-w4pbq2lb	424	32	into	into	IN
cord-267897-w4pbq2lb	424	33	the	the	DT
cord-267897-w4pbq2lb	424	34	modeling	modeling	NN
cord-267897-w4pbq2lb	424	35	of	of	IN
cord-267897-w4pbq2lb	424	36	adsorption	adsorption	NN
cord-267897-w4pbq2lb	424	37	isotherm	isotherm	NN
cord-267897-w4pbq2lb	424	38	systems	system	NNS
cord-267897-w4pbq2lb	425	1	The	the	DT
cord-267897-w4pbq2lb	425	2	comparative	comparative	JJ
cord-267897-w4pbq2lb	425	3	selectivity	selectivity	NN
cord-267897-w4pbq2lb	425	4	of	of	IN
cord-267897-w4pbq2lb	425	5	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	425	6	for	for	IN
cord-267897-w4pbq2lb	425	7	humoral	humoral	JJ
cord-267897-w4pbq2lb	425	8	and	and	CC
cord-267897-w4pbq2lb	425	9	cell	cell	NN
cord-267897-w4pbq2lb	425	10	-	-	HYPH
cord-267897-w4pbq2lb	425	11	mediated	mediate	VBN
cord-267897-w4pbq2lb	425	12	immunity	immunity	NN
cord-267897-w4pbq2lb	425	13	.	.	.
cord-267897-w4pbq2lb	426	1	II	II	NNP
cord-267897-w4pbq2lb	426	2	.	.	.
cord-267897-w4pbq2lb	427	1	Effect	effect	NN
cord-267897-w4pbq2lb	427	2	on	on	IN
cord-267897-w4pbq2lb	427	3	delayed	delay	VBN
cord-267897-w4pbq2lb	427	4	-	-	HYPH
cord-267897-w4pbq2lb	427	5	type	type	NN
cord-267897-w4pbq2lb	427	6	hypersensitivity	hypersensitivity	NN
cord-267897-w4pbq2lb	427	7	in	in	IN
cord-267897-w4pbq2lb	427	8	the	the	DT
cord-267897-w4pbq2lb	427	9	mouse	mouse	NN
cord-267897-w4pbq2lb	427	10	and	and	CC
cord-267897-w4pbq2lb	427	11	guinea	guinea	NN
cord-267897-w4pbq2lb	427	12	pig	pig	NN
cord-267897-w4pbq2lb	427	13	,	,	,
cord-267897-w4pbq2lb	427	14	and	and	CC
cord-267897-w4pbq2lb	427	15	cell	cell	NN
cord-267897-w4pbq2lb	427	16	-	-	HYPH
cord-267897-w4pbq2lb	427	17	mediated	mediate	VBN
cord-267897-w4pbq2lb	427	18	immunity	immunity	NN
cord-267897-w4pbq2lb	427	19	to	to	IN
cord-267897-w4pbq2lb	427	20	tumour	tumour	NN
cord-267897-w4pbq2lb	427	21	antigens	antigen	NNS
cord-267897-w4pbq2lb	427	22	in	in	IN
cord-267897-w4pbq2lb	427	23	the	the	DT
cord-267897-w4pbq2lb	427	24	mouse	mouse	NN
cord-267897-w4pbq2lb	427	25	of	of	IN
cord-267897-w4pbq2lb	427	26	Freund	Freund	NNP
cord-267897-w4pbq2lb	427	27	's	's	POS
cord-267897-w4pbq2lb	427	28	incomplete	incomplete	JJ
cord-267897-w4pbq2lb	427	29	and	and	CC
cord-267897-w4pbq2lb	427	30	complete	complete	JJ
cord-267897-w4pbq2lb	427	31	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	427	32	,	,	,
cord-267897-w4pbq2lb	427	33	alhydrogel	alhydrogel	NN
cord-267897-w4pbq2lb	427	34	,	,	,
cord-267897-w4pbq2lb	427	35	Corynebacterium	Corynebacterium	NNP
cord-267897-w4pbq2lb	427	36	parvum	parvum	NN
cord-267897-w4pbq2lb	427	37	,	,	,
cord-267897-w4pbq2lb	427	38	Bordetella	Bordetella	NNP
cord-267897-w4pbq2lb	427	39	pertussis	pertussis	NN
cord-267897-w4pbq2lb	427	40	,	,	,
cord-267897-w4pbq2lb	427	41	muramyl	muramyl	NNP
cord-267897-w4pbq2lb	427	42	dipeptide	dipeptide	NNP
cord-267897-w4pbq2lb	427	43	and	and	CC
cord-267897-w4pbq2lb	427	44	saponin	saponin	NN
cord-267897-w4pbq2lb	427	45	Induction	induction	NN
cord-267897-w4pbq2lb	427	46	of	of	IN
cord-267897-w4pbq2lb	427	47	protective	protective	JJ
cord-267897-w4pbq2lb	427	48	class	class	NN
cord-267897-w4pbq2lb	428	1	I	-PRON-	PRP
cord-267897-w4pbq2lb	428	2	MHC	MHC	NNP
cord-267897-w4pbq2lb	428	3	-	-	HYPH
cord-267897-w4pbq2lb	428	4	restricted	restrict	VBN
cord-267897-w4pbq2lb	428	5	CTL	CTL	NNP
cord-267897-w4pbq2lb	428	6	in	in	IN
cord-267897-w4pbq2lb	428	7	mice	mouse	NNS
cord-267897-w4pbq2lb	428	8	by	by	IN
cord-267897-w4pbq2lb	428	9	a	a	DT
cord-267897-w4pbq2lb	428	10	recombinant	recombinant	JJ
cord-267897-w4pbq2lb	428	11	influenza	influenza	NN
cord-267897-w4pbq2lb	428	12	vaccine	vaccine	NN
cord-267897-w4pbq2lb	428	13	in	in	IN
cord-267897-w4pbq2lb	428	14	aluminium	aluminium	NN
cord-267897-w4pbq2lb	428	15	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	428	16	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	428	17	Eosinophil	eosinophil	JJ
cord-267897-w4pbq2lb	428	18	response	response	NN
cord-267897-w4pbq2lb	428	19	to	to	IN
cord-267897-w4pbq2lb	428	20	alum	alum	NN
cord-267897-w4pbq2lb	428	21	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	429	1	:	:	:
cord-267897-w4pbq2lb	429	2	involvement	involvement	NN
cord-267897-w4pbq2lb	429	3	of	of	IN
cord-267897-w4pbq2lb	429	4	T	T	NNP
cord-267897-w4pbq2lb	429	5	cells	cell	NNS
cord-267897-w4pbq2lb	429	6	in	in	IN
cord-267897-w4pbq2lb	429	7	non	non	JJ
cord-267897-w4pbq2lb	429	8	-	-	JJ
cord-267897-w4pbq2lb	429	9	antigen	antigen	JJ
cord-267897-w4pbq2lb	429	10	-	-	HYPH
cord-267897-w4pbq2lb	429	11	dependent	dependent	JJ
cord-267897-w4pbq2lb	429	12	mechanisms	mechanism	NNS
cord-267897-w4pbq2lb	429	13	Different	different	JJ
cord-267897-w4pbq2lb	429	14	T	t	NN
cord-267897-w4pbq2lb	429	15	helper	helper	NN
cord-267897-w4pbq2lb	429	16	cell	cell	NN
cord-267897-w4pbq2lb	429	17	subsets	subset	NNS
cord-267897-w4pbq2lb	429	18	elicited	elicit	VBN
cord-267897-w4pbq2lb	429	19	in	in	IN
cord-267897-w4pbq2lb	429	20	mice	mouse	NNS
cord-267897-w4pbq2lb	429	21	utilizing	utilize	VBG
cord-267897-w4pbq2lb	429	22	two	two	CD
cord-267897-w4pbq2lb	429	23	different	different	JJ
cord-267897-w4pbq2lb	429	24	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	429	25	vehicles	vehicle	NNS
cord-267897-w4pbq2lb	429	26	.	.	.
cord-267897-w4pbq2lb	430	1	The	the	DT
cord-267897-w4pbq2lb	430	2	role	role	NN
cord-267897-w4pbq2lb	430	3	of	of	IN
cord-267897-w4pbq2lb	430	4	endogenous	endogenous	JJ
cord-267897-w4pbq2lb	430	5	interleukin	interleukin	NN
cord-267897-w4pbq2lb	430	6	-	-	HYPH
cord-267897-w4pbq2lb	430	7	l	l	NN
cord-267897-w4pbq2lb	430	8	in	in	IN
cord-267897-w4pbq2lb	430	9	proliferative	proliferative	JJ
cord-267897-w4pbq2lb	430	10	responses	response	NNS
cord-267897-w4pbq2lb	430	11	A	a	DT
cord-267897-w4pbq2lb	430	12	limited	limited	JJ
cord-267897-w4pbq2lb	430	13	role	role	NN
cord-267897-w4pbq2lb	430	14	of	of	IN
cord-267897-w4pbq2lb	430	15	IL-1	IL-1	NNP
cord-267897-w4pbq2lb	430	16	in	in	IN
cord-267897-w4pbq2lb	430	17	immuneenhancement	immuneenhancement	NN
cord-267897-w4pbq2lb	430	18	by	by	IN
cord-267897-w4pbq2lb	430	19	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	430	20	Adsorption	Adsorption	NNP
cord-267897-w4pbq2lb	430	21	to	to	TO
cord-267897-w4pbq2lb	430	22	aluminium	aluminium	VB
cord-267897-w4pbq2lb	430	23	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	430	24	promotes	promote	VBZ
cord-267897-w4pbq2lb	430	25	the	the	DT
cord-267897-w4pbq2lb	430	26	activity	activity	NN
cord-267897-w4pbq2lb	430	27	of	of	IN
cord-267897-w4pbq2lb	430	28	IL-12	IL-12	NNP
cord-267897-w4pbq2lb	430	29	as	as	IN
cord-267897-w4pbq2lb	430	30	an	an	DT
cord-267897-w4pbq2lb	430	31	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	430	32	for	for	IN
cord-267897-w4pbq2lb	430	33	antibody	antibody	NN
cord-267897-w4pbq2lb	430	34	as	as	RB
cord-267897-w4pbq2lb	430	35	well	well	RB
cord-267897-w4pbq2lb	430	36	as	as	IN
cord-267897-w4pbq2lb	430	37	type	type	NN
cord-267897-w4pbq2lb	430	38	1	1	CD
cord-267897-w4pbq2lb	430	39	cytokine	cytokine	NN
cord-267897-w4pbq2lb	430	40	responses	response	NNS
cord-267897-w4pbq2lb	430	41	to	to	IN
cord-267897-w4pbq2lb	430	42	HIV-1	HIV-1	NNP
cord-267897-w4pbq2lb	430	43	gp	gp	NN
cord-267897-w4pbq2lb	430	44	120	120	CD
cord-267897-w4pbq2lb	431	1	Interleukin-18	Interleukin-18	NNP
cord-267897-w4pbq2lb	431	2	plays	play	VBZ
cord-267897-w4pbq2lb	431	3	a	a	DT
cord-267897-w4pbq2lb	431	4	role	role	NN
cord-267897-w4pbq2lb	431	5	in	in	IN
cord-267897-w4pbq2lb	431	6	both	both	CC
cord-267897-w4pbq2lb	431	7	the	the	DT
cord-267897-w4pbq2lb	431	8	alum	alum	NN
cord-267897-w4pbq2lb	431	9	-	-	HYPH
cord-267897-w4pbq2lb	431	10	induced	induce	VBN
cord-267897-w4pbq2lb	431	11	T	T	NNP
cord-267897-w4pbq2lb	431	12	helper	helper	NN
cord-267897-w4pbq2lb	431	13	2	2	CD
cord-267897-w4pbq2lb	431	14	response	response	NN
cord-267897-w4pbq2lb	431	15	and	and	CC
cord-267897-w4pbq2lb	431	16	the	the	DT
cord-267897-w4pbq2lb	431	17	T	T	NNP
cord-267897-w4pbq2lb	431	18	helper	helper	NN
cord-267897-w4pbq2lb	431	19	1	1	CD
cord-267897-w4pbq2lb	431	20	response	response	NN
cord-267897-w4pbq2lb	431	21	induced	induce	VBN
cord-267897-w4pbq2lb	431	22	by	by	IN
cord-267897-w4pbq2lb	431	23	alum	alum	NN
cord-267897-w4pbq2lb	431	24	-	-	HYPH
cord-267897-w4pbq2lb	431	25	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	431	26	interleukin-12	interleukin-12	NNP
cord-267897-w4pbq2lb	431	27	In	in	IN
cord-267897-w4pbq2lb	431	28	interleukin-4-deficient	interleukin-4-deficient	NNP
cord-267897-w4pbq2lb	431	29	mice	mouse	NNS
cord-267897-w4pbq2lb	431	30	,	,	,
cord-267897-w4pbq2lb	431	31	alum	alum	NN
cord-267897-w4pbq2lb	431	32	not	not	RB
cord-267897-w4pbq2lb	431	33	only	only	RB
cord-267897-w4pbq2lb	431	34	generates	generate	VBZ
cord-267897-w4pbq2lb	431	35	T	T	NNP
cord-267897-w4pbq2lb	431	36	helper	helper	NN
cord-267897-w4pbq2lb	431	37	1	1	CD
cord-267897-w4pbq2lb	431	38	responses	response	NNS
cord-267897-w4pbq2lb	431	39	equivalent	equivalent	JJ
cord-267897-w4pbq2lb	431	40	to	to	IN
cord-267897-w4pbq2lb	431	41	Freund	Freund	NNP
cord-267897-w4pbq2lb	431	42	's	's	POS
cord-267897-w4pbq2lb	431	43	complete	complete	JJ
cord-267897-w4pbq2lb	431	44	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	431	45	,	,	,
cord-267897-w4pbq2lb	431	46	but	but	CC
cord-267897-w4pbq2lb	431	47	continues	continue	VBZ
cord-267897-w4pbq2lb	431	48	to	to	TO
cord-267897-w4pbq2lb	431	49	induce	induce	VB
cord-267897-w4pbq2lb	431	50	T	T	NNP
cord-267897-w4pbq2lb	431	51	helper	helper	NN
cord-267897-w4pbq2lb	431	52	2	2	CD
cord-267897-w4pbq2lb	431	53	cytokine	cytokine	NN
cord-267897-w4pbq2lb	431	54	production	production	NN
cord-267897-w4pbq2lb	431	55	Aluminium	aluminium	NN
cord-267897-w4pbq2lb	431	56	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	431	57	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	431	58	initiates	initiate	VBZ
cord-267897-w4pbq2lb	431	59	strong	strong	JJ
cord-267897-w4pbq2lb	431	60	antigen	antigen	NN
cord-267897-w4pbq2lb	431	61	-	-	HYPH
cord-267897-w4pbq2lb	431	62	specific	specific	JJ
cord-267897-w4pbq2lb	431	63	Th2	th2	CD
cord-267897-w4pbq2lb	431	64	responses	response	NNS
cord-267897-w4pbq2lb	431	65	in	in	IN
cord-267897-w4pbq2lb	431	66	the	the	DT
cord-267897-w4pbq2lb	431	67	absence	absence	NN
cord-267897-w4pbq2lb	431	68	of	of	IN
cord-267897-w4pbq2lb	431	69	IL-4-or	il-4-or	NN
cord-267897-w4pbq2lb	432	1	IL-13-mediated	il-13-mediate	VBN
cord-267897-w4pbq2lb	432	2	signaling	signal	VBG
cord-267897-w4pbq2lb	432	3	The	the	DT
cord-267897-w4pbq2lb	432	4	common	common	JJ
cord-267897-w4pbq2lb	432	5	vaccine	vaccine	NN
cord-267897-w4pbq2lb	432	6	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	432	7	aluminum	aluminum	NN
cord-267897-w4pbq2lb	432	8	HGydroxide	HGydroxide	NNP
cord-267897-w4pbq2lb	432	9	up	up	RB
cord-267897-w4pbq2lb	432	10	-	-	HYPH
cord-267897-w4pbq2lb	432	11	regulates	regulate	VBZ
cord-267897-w4pbq2lb	432	12	accessory	accessory	NN
cord-267897-w4pbq2lb	432	13	properties	property	NNS
cord-267897-w4pbq2lb	432	14	of	of	IN
cord-267897-w4pbq2lb	432	15	human	human	JJ
cord-267897-w4pbq2lb	432	16	monocytes	monocyte	NNS
cord-267897-w4pbq2lb	432	17	via	via	IN
cord-267897-w4pbq2lb	432	18	an	an	DT
cord-267897-w4pbq2lb	432	19	interleukin-4-dependent	interleukin-4-dependent	NNP
cord-267897-w4pbq2lb	432	20	mechanism	mechanism	NN
cord-267897-w4pbq2lb	432	21	Aluminium	aluminium	NN
cord-267897-w4pbq2lb	432	22	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	432	23	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	432	24	induces	induce	VBZ
cord-267897-w4pbq2lb	432	25	macrophage	macrophage	NN
cord-267897-w4pbq2lb	432	26	differentiation	differentiation	NN
cord-267897-w4pbq2lb	432	27	towards	towards	IN
cord-267897-w4pbq2lb	432	28	a	a	DT
cord-267897-w4pbq2lb	432	29	specialized	specialized	JJ
cord-267897-w4pbq2lb	432	30	antigen	antigen	NN
cord-267897-w4pbq2lb	432	31	-	-	HYPH
cord-267897-w4pbq2lb	432	32	presenting	present	VBG
cord-267897-w4pbq2lb	432	33	cell	cell	NN
cord-267897-w4pbq2lb	432	34	type	type	NN
cord-267897-w4pbq2lb	433	1	The	the	DT
cord-267897-w4pbq2lb	433	2	inflammasome	inflammasome	NN
cord-267897-w4pbq2lb	433	3	:	:	:
cord-267897-w4pbq2lb	433	4	a	a	DT
cord-267897-w4pbq2lb	433	5	molecular	molecular	JJ
cord-267897-w4pbq2lb	433	6	platform	platform	NN
cord-267897-w4pbq2lb	433	7	triggering	trigger	VBG
cord-267897-w4pbq2lb	433	8	activation	activation	NN
cord-267897-w4pbq2lb	433	9	of	of	IN
cord-267897-w4pbq2lb	433	10	inflammatory	inflammatory	JJ
cord-267897-w4pbq2lb	433	11	caspases	caspase	NNS
cord-267897-w4pbq2lb	433	12	and	and	CC
cord-267897-w4pbq2lb	433	13	processing	processing	NN
cord-267897-w4pbq2lb	433	14	of	of	IN
cord-267897-w4pbq2lb	433	15	pro	pro	JJ
cord-267897-w4pbq2lb	433	16	-	-	JJ
cord-267897-w4pbq2lb	433	17	IL	IL	NNP
cord-267897-w4pbq2lb	433	18	-	-	HYPH
cord-267897-w4pbq2lb	433	19	b	b	NNP
cord-267897-w4pbq2lb	433	20	Silica	silica	NN
cord-267897-w4pbq2lb	433	21	crystals	crystal	NNS
cord-267897-w4pbq2lb	433	22	and	and	CC
cord-267897-w4pbq2lb	433	23	aluminum	aluminum	NN
cord-267897-w4pbq2lb	433	24	salts	salt	NNS
cord-267897-w4pbq2lb	433	25	activate	activate	VBP
cord-267897-w4pbq2lb	433	26	the	the	DT
cord-267897-w4pbq2lb	433	27	NALP3	NALP3	NNP
cord-267897-w4pbq2lb	433	28	inflammasome	inflammasome	NNP
cord-267897-w4pbq2lb	433	29	via	via	IN
cord-267897-w4pbq2lb	433	30	phagosomal	phagosomal	NN
cord-267897-w4pbq2lb	433	31	destabilization	destabilization	NN
cord-267897-w4pbq2lb	433	32	Cutting	cutting	NN
cord-267897-w4pbq2lb	433	33	edge	edge	NN
cord-267897-w4pbq2lb	433	34	:	:	:
cord-267897-w4pbq2lb	433	35	alum	alum	NN
cord-267897-w4pbq2lb	433	36	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	433	37	stimulates	stimulate	VBZ
cord-267897-w4pbq2lb	433	38	inflammatory	inflammatory	JJ
cord-267897-w4pbq2lb	433	39	dendritic	dendritic	JJ
cord-267897-w4pbq2lb	433	40	cells	cell	NNS
cord-267897-w4pbq2lb	433	41	through	through	IN
cord-267897-w4pbq2lb	433	42	activation	activation	NN
cord-267897-w4pbq2lb	433	43	of	of	IN
cord-267897-w4pbq2lb	433	44	the	the	DT
cord-267897-w4pbq2lb	433	45	NALP3	NALP3	NNP
cord-267897-w4pbq2lb	433	46	inflammasome	inflammasome	NNP
cord-267897-w4pbq2lb	433	47	Aluminum	Aluminum	NNP
cord-267897-w4pbq2lb	433	48	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	433	49	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	433	50	activate	activate	VBP
cord-267897-w4pbq2lb	433	51	caspase-1	caspase-1	NNP
cord-267897-w4pbq2lb	433	52	and	and	CC
cord-267897-w4pbq2lb	433	53	induce	induce	VB
cord-267897-w4pbq2lb	433	54	IL-1beta	il-1beta	NN
cord-267897-w4pbq2lb	433	55	and	and	CC
cord-267897-w4pbq2lb	433	56	IL-18	IL-18	NNP
cord-267897-w4pbq2lb	433	57	release	release	NN
cord-267897-w4pbq2lb	433	58	Cutting	cutting	NN
cord-267897-w4pbq2lb	433	59	edge	edge	NN
cord-267897-w4pbq2lb	433	60	:	:	:
cord-267897-w4pbq2lb	433	61	inflammasome	inflammasome	NNP
cord-267897-w4pbq2lb	433	62	activation	activation	NN
cord-267897-w4pbq2lb	433	63	by	by	IN
cord-267897-w4pbq2lb	433	64	alum	alum	NN
cord-267897-w4pbq2lb	433	65	and	and	CC
cord-267897-w4pbq2lb	433	66	alum	alum	NN
cord-267897-w4pbq2lb	433	67	's	's	POS
cord-267897-w4pbq2lb	433	68	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	433	69	effect	effect	NN
cord-267897-w4pbq2lb	433	70	are	be	VBP
cord-267897-w4pbq2lb	433	71	mediated	mediate	VBN
cord-267897-w4pbq2lb	433	72	by	by	IN
cord-267897-w4pbq2lb	433	73	NLRP3	nlrp3	XX
cord-267897-w4pbq2lb	434	1	Crucial	crucial	JJ
cord-267897-w4pbq2lb	434	2	role	role	NN
cord-267897-w4pbq2lb	434	3	for	for	IN
cord-267897-w4pbq2lb	434	4	the	the	DT
cord-267897-w4pbq2lb	434	5	Nalp3	Nalp3	NNP
cord-267897-w4pbq2lb	434	6	inflammasome	inflammasome	NNP
cord-267897-w4pbq2lb	434	7	in	in	IN
cord-267897-w4pbq2lb	434	8	the	the	DT
cord-267897-w4pbq2lb	434	9	immunostimulatory	immunostimulatory	NNP
cord-267897-w4pbq2lb	434	10	properties	property	NNS
cord-267897-w4pbq2lb	434	11	of	of	IN
cord-267897-w4pbq2lb	434	12	aluminium	aluminium	NN
cord-267897-w4pbq2lb	434	13	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	435	1	Molecular	molecular	JJ
cord-267897-w4pbq2lb	435	2	identification	identification	NN
cord-267897-w4pbq2lb	435	3	of	of	IN
cord-267897-w4pbq2lb	435	4	a	a	DT
cord-267897-w4pbq2lb	435	5	danger	danger	NN
cord-267897-w4pbq2lb	435	6	signal	signal	NN
cord-267897-w4pbq2lb	435	7	that	that	WDT
cord-267897-w4pbq2lb	435	8	alerts	alert	VBZ
cord-267897-w4pbq2lb	435	9	the	the	DT
cord-267897-w4pbq2lb	435	10	immune	immune	JJ
cord-267897-w4pbq2lb	435	11	system	system	NN
cord-267897-w4pbq2lb	435	12	to	to	IN
cord-267897-w4pbq2lb	435	13	dying	die	VBG
cord-267897-w4pbq2lb	435	14	cells	cell	NNS
cord-267897-w4pbq2lb	435	15	Uric	uric	NN
cord-267897-w4pbq2lb	435	16	acid	acid	NN
cord-267897-w4pbq2lb	435	17	:	:	:
cord-267897-w4pbq2lb	435	18	a	a	DT
cord-267897-w4pbq2lb	435	19	possible	possible	JJ
cord-267897-w4pbq2lb	435	20	mediator	mediator	NN
cord-267897-w4pbq2lb	435	21	of	of	IN
cord-267897-w4pbq2lb	435	22	the	the	DT
cord-267897-w4pbq2lb	435	23	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	435	24	effect	effect	NN
cord-267897-w4pbq2lb	435	25	of	of	IN
cord-267897-w4pbq2lb	435	26	alum	alum	NN
cord-267897-w4pbq2lb	435	27	in	in	IN
cord-267897-w4pbq2lb	435	28	mice	mouse	NNS
cord-267897-w4pbq2lb	435	29	immunized	immunize	VBN
cord-267897-w4pbq2lb	435	30	with	with	IN
cord-267897-w4pbq2lb	435	31	ovalbumin	ovalbumin	FW
cord-267897-w4pbq2lb	435	32	HSP70	HSP70	NNP
cord-267897-w4pbq2lb	435	33	stimulates	stimulate	VBZ
cord-267897-w4pbq2lb	435	34	cytokine	cytokine	JJ
cord-267897-w4pbq2lb	435	35	production	production	NN
cord-267897-w4pbq2lb	435	36	through	through	IN
cord-267897-w4pbq2lb	435	37	a	a	DT
cord-267897-w4pbq2lb	435	38	CD14-dependent	cd14-dependent	CD
cord-267897-w4pbq2lb	435	39	pathway	pathway	NN
cord-267897-w4pbq2lb	435	40	,	,	,
cord-267897-w4pbq2lb	435	41	demonstrating	demonstrate	VBG
cord-267897-w4pbq2lb	435	42	its	-PRON-	PRP$
cord-267897-w4pbq2lb	435	43	dual	dual	JJ
cord-267897-w4pbq2lb	435	44	role	role	NN
cord-267897-w4pbq2lb	435	45	as	as	IN
cord-267897-w4pbq2lb	435	46	a	a	DT
cord-267897-w4pbq2lb	435	47	chaperone	chaperone	NN
cord-267897-w4pbq2lb	435	48	and	and	CC
cord-267897-w4pbq2lb	435	49	a	a	DT
cord-267897-w4pbq2lb	435	50	cytokine	cytokine	JJ
cord-267897-w4pbq2lb	435	51	Novel	novel	NN
cord-267897-w4pbq2lb	435	52	signal	signal	NN
cord-267897-w4pbq2lb	435	53	transduction	transduction	NN
cord-267897-w4pbq2lb	435	54	pathway	pathway	NN
cord-267897-w4pbq2lb	435	55	utilized	utilize	VBN
cord-267897-w4pbq2lb	435	56	by	by	IN
cord-267897-w4pbq2lb	435	57	extracellular	extracellular	JJ
cord-267897-w4pbq2lb	435	58	HSP70	HSP70	NNP
cord-267897-w4pbq2lb	435	59	Influence	influence	NN
cord-267897-w4pbq2lb	435	60	of	of	IN
cord-267897-w4pbq2lb	435	61	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	435	62	on	on	IN
cord-267897-w4pbq2lb	435	63	the	the	DT
cord-267897-w4pbq2lb	435	64	quantity	quantity	NN
cord-267897-w4pbq2lb	435	65	,	,	,
cord-267897-w4pbq2lb	435	66	affinity	affinity	NN
cord-267897-w4pbq2lb	435	67	,	,	,
cord-267897-w4pbq2lb	435	68	isotype	isotype	NN
cord-267897-w4pbq2lb	435	69	and	and	CC
cord-267897-w4pbq2lb	435	70	epitope	epitope	NN
cord-267897-w4pbq2lb	435	71	specificity	specificity	NN
cord-267897-w4pbq2lb	435	72	of	of	IN
cord-267897-w4pbq2lb	435	73	murine	murine	JJ
cord-267897-w4pbq2lb	435	74	antibodies	antibody	NNS
cord-267897-w4pbq2lb	435	75	Hapten	Hapten	NNP
cord-267897-w4pbq2lb	435	76	-	-	HYPH
cord-267897-w4pbq2lb	435	77	specific	specific	JJ
cord-267897-w4pbq2lb	435	78	IgE	IgE	NNP
cord-267897-w4pbq2lb	435	79	antibody	antibody	NN
cord-267897-w4pbq2lb	435	80	responses	response	NNS
cord-267897-w4pbq2lb	435	81	in	in	IN
cord-267897-w4pbq2lb	435	82	mice	mouse	NNS
cord-267897-w4pbq2lb	435	83	.	.	.
cord-267897-w4pbq2lb	436	1	I.	I.	NNP
cord-267897-w4pbq2lb	436	2	Secondary	Secondary	NNP
cord-267897-w4pbq2lb	436	3	IgE	IgE	NNP
cord-267897-w4pbq2lb	436	4	response	response	NN
cord-267897-w4pbq2lb	436	5	in	in	IN
cord-267897-w4pbq2lb	436	6	irradiated	irradiate	VBN
cord-267897-w4pbq2lb	436	7	recipients	recipient	NNS
cord-267897-w4pbq2lb	436	8	of	of	IN
cord-267897-w4pbq2lb	436	9	syngeneic	syngeneic	NNS
cord-267897-w4pbq2lb	436	10	primed	prime	VBN
cord-267897-w4pbq2lb	436	11	spleen	spleen	NN
cord-267897-w4pbq2lb	436	12	cells	cell	NNS
cord-267897-w4pbq2lb	436	13	formation	formation	NN
cord-267897-w4pbq2lb	436	14	of	of	IN
cord-267897-w4pbq2lb	436	15	IgE	IgE	NNP
cord-267897-w4pbq2lb	436	16	binding	binding	NN
cord-267897-w4pbq2lb	436	17	factors	factor	NNS
cord-267897-w4pbq2lb	436	18	by	by	IN
cord-267897-w4pbq2lb	436	19	rat	rat	NN
cord-267897-w4pbq2lb	436	20	T	t	NN
cord-267897-w4pbq2lb	436	21	lymphocytes	lymphocyte	NNS
cord-267897-w4pbq2lb	436	22	.	.	.
cord-267897-w4pbq2lb	437	1	V.	V.	NNP
cord-267897-w4pbq2lb	437	2	Effect	Effect	NNP
cord-267897-w4pbq2lb	437	3	of	of	IN
cord-267897-w4pbq2lb	437	4	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	437	5	for	for	IN
cord-267897-w4pbq2lb	437	6	the	the	DT
cord-267897-w4pbq2lb	437	7	priming	prime	VBG
cord-267897-w4pbq2lb	437	8	immunization	immunization	NN
cord-267897-w4pbq2lb	437	9	on	on	IN
cord-267897-w4pbq2lb	437	10	the	the	DT
cord-267897-w4pbq2lb	437	11	nature	nature	NN
cord-267897-w4pbq2lb	437	12	of	of	IN
cord-267897-w4pbq2lb	437	13	Ig	Ig	NNP
cord-267897-w4pbq2lb	437	14	E	e	NN
cord-267897-w4pbq2lb	437	15	binding	binding	NN
cord-267897-w4pbq2lb	437	16	factors	factor	NNS
cord-267897-w4pbq2lb	437	17	formed	form	VBN
cord-267897-w4pbq2lb	437	18	by	by	IN
cord-267897-w4pbq2lb	437	19	antigenic	antigenic	JJ
cord-267897-w4pbq2lb	437	20	stimulation	stimulation	NN
cord-267897-w4pbq2lb	437	21	formation	formation	NN
cord-267897-w4pbq2lb	437	22	of	of	IN
cord-267897-w4pbq2lb	437	23	IgE	IgE	NNP
cord-267897-w4pbq2lb	437	24	binding	binding	NN
cord-267897-w4pbq2lb	437	25	factors	factor	NNS
cord-267897-w4pbq2lb	437	26	by	by	IN
cord-267897-w4pbq2lb	437	27	rat	rat	NN
cord-267897-w4pbq2lb	437	28	T	t	NN
cord-267897-w4pbq2lb	437	29	lymphocytes	lymphocyte	NNS
cord-267897-w4pbq2lb	437	30	.	.	.
cord-267897-w4pbq2lb	438	1	VI	VI	NNP
cord-267897-w4pbq2lb	438	2	.	.	.
cord-267897-w4pbq2lb	439	1	Cellular	cellular	JJ
cord-267897-w4pbq2lb	439	2	mechanisms	mechanism	NNS
cord-267897-w4pbq2lb	439	3	for	for	IN
cord-267897-w4pbq2lb	439	4	the	the	DT
cord-267897-w4pbq2lb	439	5	formation	formation	NN
cord-267897-w4pbq2lb	439	6	of	of	IN
cord-267897-w4pbq2lb	439	7	IgE	IgE	NNP
cord-267897-w4pbq2lb	439	8	-	-	HYPH
cord-267897-w4pbq2lb	439	9	potentiating	potentiate	VBG
cord-267897-w4pbq2lb	439	10	factor	factor	NN
cord-267897-w4pbq2lb	439	11	and	and	CC
cord-267897-w4pbq2lb	439	12	IgE	ige	NN
cord-267897-w4pbq2lb	439	13	-	-	HYPH
cord-267897-w4pbq2lb	439	14	suppressive	suppressive	JJ
cord-267897-w4pbq2lb	439	15	factor	factor	NN
cord-267897-w4pbq2lb	439	16	by	by	IN
cord-267897-w4pbq2lb	439	17	antigenic	antigenic	JJ
cord-267897-w4pbq2lb	439	18	stimulation	stimulation	NN
cord-267897-w4pbq2lb	439	19	of	of	IN
cord-267897-w4pbq2lb	439	20	antigen	antigen	NN
cord-267897-w4pbq2lb	439	21	primed	prime	VBN
cord-267897-w4pbq2lb	439	22	spleen	spleen	NN
cord-267897-w4pbq2lb	439	23	cells	cell	NNS
cord-267897-w4pbq2lb	439	24	Aluminium	aluminium	NN
cord-267897-w4pbq2lb	439	25	phosphate	phosphate	NN
cord-267897-w4pbq2lb	439	26	but	but	CC
cord-267897-w4pbq2lb	439	27	not	not	RB
cord-267897-w4pbq2lb	439	28	calcium	calcium	NN
cord-267897-w4pbq2lb	439	29	phosphate	phosphate	NN
cord-267897-w4pbq2lb	439	30	stimulates	stimulate	VBZ
cord-267897-w4pbq2lb	439	31	the	the	DT
cord-267897-w4pbq2lb	439	32	specific	specific	JJ
cord-267897-w4pbq2lb	439	33	IgE	IgE	NNP
cord-267897-w4pbq2lb	439	34	response	response	NN
cord-267897-w4pbq2lb	439	35	in	in	IN
cord-267897-w4pbq2lb	439	36	guinea	guinea	NN
cord-267897-w4pbq2lb	439	37	pigs	pig	NNS
cord-267897-w4pbq2lb	439	38	to	to	IN
cord-267897-w4pbq2lb	439	39	tetanus	tetanus	NN
cord-267897-w4pbq2lb	440	1	toxoid	toxoid	NNP
cord-267897-w4pbq2lb	440	2	Induction	Induction	NNP
cord-267897-w4pbq2lb	440	3	of	of	IN
cord-267897-w4pbq2lb	440	4	resistance	resistance	NN
cord-267897-w4pbq2lb	440	5	to	to	IN
cord-267897-w4pbq2lb	440	6	Schistosoma	Schistosoma	NNP
cord-267897-w4pbq2lb	440	7	mansoni	mansoni	NNP
cord-267897-w4pbq2lb	440	8	by	by	IN
cord-267897-w4pbq2lb	440	9	immunization	immunization	NN
cord-267897-w4pbq2lb	440	10	with	with	IN
cord-267897-w4pbq2lb	440	11	subfractions	subfraction	NNS
cord-267897-w4pbq2lb	440	12	of	of	IN
cord-267897-w4pbq2lb	440	13	worms	worm	NNS
cord-267897-w4pbq2lb	440	14	Protection	Protection	NNP
cord-267897-w4pbq2lb	440	15	against	against	IN
cord-267897-w4pbq2lb	440	16	Schistosoma	Schistosoma	NNP
cord-267897-w4pbq2lb	440	17	mansoni	mansoni	NN
cord-267897-w4pbq2lb	440	18	achieved	achieve	VBN
cord-267897-w4pbq2lb	440	19	by	by	IN
cord-267897-w4pbq2lb	440	20	immunization	immunization	NN
cord-267897-w4pbq2lb	440	21	with	with	IN
cord-267897-w4pbq2lb	440	22	sonicated	sonicated	JJ
cord-267897-w4pbq2lb	440	23	parasite	parasite	NN
cord-267897-w4pbq2lb	440	24	Updated	update	VBN
cord-267897-w4pbq2lb	440	25	aluminum	aluminum	NN
cord-267897-w4pbq2lb	440	26	pharmacokinetics	pharmacokinetic	NNS
cord-267897-w4pbq2lb	440	27	following	follow	VBG
cord-267897-w4pbq2lb	440	28	infant	infant	NN
cord-267897-w4pbq2lb	440	29	exposures	exposure	NNS
cord-267897-w4pbq2lb	440	30	through	through	IN
cord-267897-w4pbq2lb	440	31	diet	diet	NN
cord-267897-w4pbq2lb	440	32	and	and	CC
cord-267897-w4pbq2lb	440	33	vaccination	vaccination	NN
cord-267897-w4pbq2lb	440	34	Aluminum	Aluminum	NNP
cord-267897-w4pbq2lb	440	35	and	and	CC
cord-267897-w4pbq2lb	440	36	Alzheimer	Alzheimer	NNP
cord-267897-w4pbq2lb	440	37	's	's	POS
cord-267897-w4pbq2lb	440	38	disease	disease	NN
cord-267897-w4pbq2lb	440	39	:	:	:
cord-267897-w4pbq2lb	440	40	after	after	IN
cord-267897-w4pbq2lb	440	41	a	a	DT
cord-267897-w4pbq2lb	440	42	century	century	NN
cord-267897-w4pbq2lb	440	43	of	of	IN
cord-267897-w4pbq2lb	440	44	controversy	controversy	NN
cord-267897-w4pbq2lb	440	45	,	,	,
cord-267897-w4pbq2lb	440	46	is	be	VBZ
cord-267897-w4pbq2lb	440	47	there	there	EX
cord-267897-w4pbq2lb	440	48	a	a	DT
cord-267897-w4pbq2lb	440	49	plausible	plausible	JJ
cord-267897-w4pbq2lb	440	50	link	link	NN
cord-267897-w4pbq2lb	440	51	?	?	.
cord-267897-w4pbq2lb	441	1	Geographical	geographical	JJ
cord-267897-w4pbq2lb	441	2	relation	relation	NN
cord-267897-w4pbq2lb	441	3	between	between	IN
cord-267897-w4pbq2lb	441	4	Alzheimers	Alzheimers	NNP
cord-267897-w4pbq2lb	441	5	disease	disease	NN
cord-267897-w4pbq2lb	441	6	and	and	CC
cord-267897-w4pbq2lb	441	7	aluminium	aluminium	NN
cord-267897-w4pbq2lb	441	8	in	in	IN
cord-267897-w4pbq2lb	441	9	drinking	drinking	NN
cord-267897-w4pbq2lb	441	10	water	water	NN
cord-267897-w4pbq2lb	442	1	In	in	IN
cord-267897-w4pbq2lb	442	2	vivo	vivo	NN
cord-267897-w4pbq2lb	442	3	absorption	absorption	NN
cord-267897-w4pbq2lb	442	4	of	of	IN
cord-267897-w4pbq2lb	442	5	aluminium	aluminium	NN
cord-267897-w4pbq2lb	442	6	containing	contain	VBG
cord-267897-w4pbq2lb	442	7	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	442	8	using	use	VBG
cord-267897-w4pbq2lb	442	9	26	26	CD
cord-267897-w4pbq2lb	442	10	Al	Al	NNP
cord-267897-w4pbq2lb	442	11	Safety	Safety	NNP
cord-267897-w4pbq2lb	442	12	evaluation	evaluation	NN
cord-267897-w4pbq2lb	442	13	of	of	IN
cord-267897-w4pbq2lb	442	14	vaccine	vaccine	NN
cord-267897-w4pbq2lb	442	15	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	442	16	Safety	Safety	NNP
cord-267897-w4pbq2lb	442	17	evaluation	evaluation	NN
cord-267897-w4pbq2lb	442	18	of	of	IN
cord-267897-w4pbq2lb	442	19	vaccine	vaccine	NN
cord-267897-w4pbq2lb	442	20	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	442	21	Contact	contact	VBP
cord-267897-w4pbq2lb	442	22	sensitivity	sensitivity	NN
cord-267897-w4pbq2lb	442	23	to	to	IN
cord-267897-w4pbq2lb	442	24	aluminium	aluminium	NN
cord-267897-w4pbq2lb	442	25	Adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	442	26	e	e	LS
cord-267897-w4pbq2lb	442	27	a	a	DT
cord-267897-w4pbq2lb	442	28	balance	balance	NN
cord-267897-w4pbq2lb	442	29	between	between	IN
cord-267897-w4pbq2lb	442	30	toxicity	toxicity	NN
cord-267897-w4pbq2lb	442	31	and	and	CC
cord-267897-w4pbq2lb	442	32	adjuvanticity	adjuvanticity	NN
cord-267897-w4pbq2lb	442	33	Persistent	persistent	JJ
cord-267897-w4pbq2lb	442	34	subcutaneous	subcutaneous	JJ
cord-267897-w4pbq2lb	442	35	nodules	nodule	NNS
cord-267897-w4pbq2lb	442	36	in	in	IN
cord-267897-w4pbq2lb	442	37	children	child	NNS
cord-267897-w4pbq2lb	442	38	hyposensitized	hyposensitize	VBN
cord-267897-w4pbq2lb	442	39	with	with	IN
cord-267897-w4pbq2lb	442	40	aluminium	aluminium	NN
cord-267897-w4pbq2lb	442	41	-	-	HYPH
cord-267897-w4pbq2lb	442	42	containing	contain	VBG
cord-267897-w4pbq2lb	442	43	allergen	allergen	NN
cord-267897-w4pbq2lb	442	44	extracts	extract	NNS
cord-267897-w4pbq2lb	442	45	Unexpectedly	unexpectedly	RB
cord-267897-w4pbq2lb	442	46	high	high	JJ
cord-267897-w4pbq2lb	442	47	incidence	incidence	NN
cord-267897-w4pbq2lb	442	48	of	of	IN
cord-267897-w4pbq2lb	442	49	persistent	persistent	JJ
cord-267897-w4pbq2lb	442	50	itching	itching	NN
cord-267897-w4pbq2lb	442	51	nodules	nodule	NNS
cord-267897-w4pbq2lb	442	52	and	and	CC
cord-267897-w4pbq2lb	442	53	delayed	delay	VBN
cord-267897-w4pbq2lb	442	54	hypersensitivity	hypersensitivity	NN
cord-267897-w4pbq2lb	442	55	to	to	TO
cord-267897-w4pbq2lb	442	56	aluminium	aluminium	NN
cord-267897-w4pbq2lb	442	57	in	in	IN
cord-267897-w4pbq2lb	442	58	children	child	NNS
cord-267897-w4pbq2lb	442	59	after	after	IN
cord-267897-w4pbq2lb	442	60	use	use	NN
cord-267897-w4pbq2lb	442	61	of	of	IN
cord-267897-w4pbq2lb	442	62	adsorbed	adsorbed	JJ
cord-267897-w4pbq2lb	442	63	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	442	64	from	from	IN
cord-267897-w4pbq2lb	442	65	a	a	DT
cord-267897-w4pbq2lb	442	66	single	single	JJ
cord-267897-w4pbq2lb	442	67	manufacturer	manufacturer	NN
cord-267897-w4pbq2lb	442	68	Lipopolysaccharides	Lipopolysaccharides	NNP
cord-267897-w4pbq2lb	442	69	of	of	IN
cord-267897-w4pbq2lb	442	70	Bordetella	Bordetella	NNP
cord-267897-w4pbq2lb	442	71	pertussis	pertussis	NN
cord-267897-w4pbq2lb	442	72	endotoxin	endotoxin	NN
cord-267897-w4pbq2lb	442	73	Alzheimer	Alzheimer	NNP
cord-267897-w4pbq2lb	442	74	's	's	POS
cord-267897-w4pbq2lb	442	75	disease	disease	NN
cord-267897-w4pbq2lb	442	76	:	:	:
cord-267897-w4pbq2lb	442	77	X	x	NN
cord-267897-w4pbq2lb	442	78	-	-	NN
cord-267897-w4pbq2lb	442	79	ray	ray	NN
cord-267897-w4pbq2lb	442	80	spectrometric	spectrometric	JJ
cord-267897-w4pbq2lb	442	81	evidence	evidence	NN
cord-267897-w4pbq2lb	442	82	of	of	IN
cord-267897-w4pbq2lb	442	83	aluminum	aluminum	NN
cord-267897-w4pbq2lb	442	84	accumulation	accumulation	NN
cord-267897-w4pbq2lb	442	85	in	in	IN
cord-267897-w4pbq2lb	442	86	neurofibrillary	neurofibrillary	JJ
cord-267897-w4pbq2lb	442	87	tangle	tangle	NN
cord-267897-w4pbq2lb	442	88	-	-	HYPH
cord-267897-w4pbq2lb	442	89	bearing	bear	VBG
cord-267897-w4pbq2lb	442	90	neurons	neuron	NNS
cord-267897-w4pbq2lb	442	91	Brain	Brain	NNP
cord-267897-w4pbq2lb	442	92	aluminum	aluminum	NN
cord-267897-w4pbq2lb	442	93	,	,	,
cord-267897-w4pbq2lb	442	94	magnesium	magnesium	NN
cord-267897-w4pbq2lb	442	95	and	and	CC
cord-267897-w4pbq2lb	442	96	phosphorus	phosphorus	NN
cord-267897-w4pbq2lb	442	97	contents	content	NNS
cord-267897-w4pbq2lb	442	98	of	of	IN
cord-267897-w4pbq2lb	442	99	control	control	NN
cord-267897-w4pbq2lb	442	100	and	and	CC
cord-267897-w4pbq2lb	442	101	Alzheimer	Alzheimer	NNP
cord-267897-w4pbq2lb	442	102	-	-	HYPH
cord-267897-w4pbq2lb	442	103	diseased	disease	VBN
cord-267897-w4pbq2lb	442	104	patients	patient	NNS
cord-267897-w4pbq2lb	443	1	Absence	absence	NN
cord-267897-w4pbq2lb	443	2	of	of	IN
cord-267897-w4pbq2lb	443	3	aluminium	aluminium	NN
cord-267897-w4pbq2lb	443	4	in	in	IN
cord-267897-w4pbq2lb	443	5	Alzheimer	Alzheimer	NNP
cord-267897-w4pbq2lb	443	6	's	's	POS
cord-267897-w4pbq2lb	443	7	disease	disease	NN
cord-267897-w4pbq2lb	443	8	brain	brain	NN
cord-267897-w4pbq2lb	443	9	tissue	tissue	NN
cord-267897-w4pbq2lb	443	10	:	:	:
cord-267897-w4pbq2lb	443	11	electron	electron	NN
cord-267897-w4pbq2lb	443	12	microprobe	microprobe	NN
cord-267897-w4pbq2lb	443	13	and	and	CC
cord-267897-w4pbq2lb	443	14	ion	ion	NN
cord-267897-w4pbq2lb	443	15	microprobe	microprobe	NN
cord-267897-w4pbq2lb	443	16	studies	study	NNS
cord-267897-w4pbq2lb	444	1	Absence	absence	NN
cord-267897-w4pbq2lb	444	2	of	of	IN
cord-267897-w4pbq2lb	444	3	aluminium	aluminium	NN
cord-267897-w4pbq2lb	444	4	in	in	IN
cord-267897-w4pbq2lb	445	1	neuritic	neuritic	JJ
cord-267897-w4pbq2lb	445	2	plaque	plaque	NN
cord-267897-w4pbq2lb	445	3	cores	core	NNS
cord-267897-w4pbq2lb	445	4	in	in	IN
cord-267897-w4pbq2lb	445	5	Alzheimer	Alzheimer	NNP
cord-267897-w4pbq2lb	445	6	's	's	POS
cord-267897-w4pbq2lb	445	7	disease	disease	NN
cord-267897-w4pbq2lb	445	8	Microanalysis	Microanalysis	NNP
cord-267897-w4pbq2lb	445	9	of	of	IN
cord-267897-w4pbq2lb	445	10	senile	senile	JJ
cord-267897-w4pbq2lb	445	11	plaques	plaque	NNS
cord-267897-w4pbq2lb	445	12	using	use	VBG
cord-267897-w4pbq2lb	445	13	nuclear	nuclear	JJ
cord-267897-w4pbq2lb	445	14	microscopy	microscopy	NNS
cord-267897-w4pbq2lb	445	15	Local	local	JJ
cord-267897-w4pbq2lb	445	16	tissue	tissue	NN
cord-267897-w4pbq2lb	445	17	irritating	irritating	JJ
cord-267897-w4pbq2lb	445	18	effects	effect	NNS
cord-267897-w4pbq2lb	445	19	and	and	CC
cord-267897-w4pbq2lb	445	20	adjuvant	adjuvant	JJ
cord-267897-w4pbq2lb	445	21	activities	activity	NNS
cord-267897-w4pbq2lb	445	22	of	of	IN
cord-267897-w4pbq2lb	445	23	calcium	calcium	NN
cord-267897-w4pbq2lb	445	24	phosphate	phosphate	NN
cord-267897-w4pbq2lb	445	25	and	and	CC
cord-267897-w4pbq2lb	445	26	aluminium	aluminium	NN
cord-267897-w4pbq2lb	445	27	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	445	28	with	with	IN
cord-267897-w4pbq2lb	445	29	different	different	JJ
cord-267897-w4pbq2lb	445	30	physical	physical	JJ
cord-267897-w4pbq2lb	445	31	properties	property	NNS
cord-267897-w4pbq2lb	445	32	Reactions	reaction	NNS
cord-267897-w4pbq2lb	445	33	and	and	CC
cord-267897-w4pbq2lb	445	34	antibody	antibody	NN
cord-267897-w4pbq2lb	445	35	responses	response	NNS
cord-267897-w4pbq2lb	445	36	to	to	IN
cord-267897-w4pbq2lb	445	37	reinforcing	reinforce	VBG
cord-267897-w4pbq2lb	445	38	doses	dose	NNS
cord-267897-w4pbq2lb	445	39	of	of	IN
cord-267897-w4pbq2lb	445	40	adsorbed	adsorbed	JJ
cord-267897-w4pbq2lb	445	41	and	and	CC
cord-267897-w4pbq2lb	445	42	plain	plain	JJ
cord-267897-w4pbq2lb	445	43	tetanus	tetanus	NN
cord-267897-w4pbq2lb	445	44	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	445	45	Aluminium	aluminium	NN
cord-267897-w4pbq2lb	445	46	compounds	compound	NNS
cord-267897-w4pbq2lb	445	47	as	as	IN
cord-267897-w4pbq2lb	445	48	adjuvants	adjuvant	NNS
cord-267897-w4pbq2lb	445	49	for	for	IN
cord-267897-w4pbq2lb	445	50	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	445	51	and	and	CC
cord-267897-w4pbq2lb	445	52	toxoids	toxoid	NNS
cord-267897-w4pbq2lb	445	53	in	in	IN
cord-267897-w4pbq2lb	445	54	man	man	NN
cord-267897-w4pbq2lb	445	55	:	:	:
cord-267897-w4pbq2lb	446	1	a	a	DT
cord-267897-w4pbq2lb	446	2	review	review	NN
cord-267897-w4pbq2lb	447	1	Advantages	advantage	NNS
cord-267897-w4pbq2lb	447	2	of	of	IN
cord-267897-w4pbq2lb	447	3	aluminium	aluminium	NN
cord-267897-w4pbq2lb	447	4	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	447	5	adsorbed	adsorb	VBN
cord-267897-w4pbq2lb	447	6	combined	combine	VBN
cord-267897-w4pbq2lb	447	7	diphtheria	diphtheria	NN
cord-267897-w4pbq2lb	447	8	,	,	,
cord-267897-w4pbq2lb	447	9	tetanus	tetanus	NN
cord-267897-w4pbq2lb	447	10	,	,	,
cord-267897-w4pbq2lb	447	11	and	and	CC
cord-267897-w4pbq2lb	447	12	pertussis	pertussis	NN
cord-267897-w4pbq2lb	447	13	vaccines	vaccine	NNS
cord-267897-w4pbq2lb	447	14	for	for	IN
cord-267897-w4pbq2lb	447	15	the	the	DT
cord-267897-w4pbq2lb	447	16	immunization	immunization	NN
cord-267897-w4pbq2lb	447	17	of	of	IN
cord-267897-w4pbq2lb	447	18	infants	infant	NNS
cord-267897-w4pbq2lb	447	19	Detoxification	detoxification	NN
cord-267897-w4pbq2lb	447	20	of	of	IN
cord-267897-w4pbq2lb	447	21	endotoxin	endotoxin	NN
cord-267897-w4pbq2lb	447	22	by	by	IN
cord-267897-w4pbq2lb	447	23	aluminium	aluminium	NN
cord-267897-w4pbq2lb	447	24	hydroxide	hydroxide	NN
cord-267897-w4pbq2lb	447	25	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	447	26	Effects	effect	NNS
cord-267897-w4pbq2lb	447	27	of	of	IN
cord-267897-w4pbq2lb	447	28	aluminium	aluminium	NN
cord-267897-w4pbq2lb	447	29	adjuvant	adjuvant	NN
cord-267897-w4pbq2lb	447	30	on	on	IN
cord-267897-w4pbq2lb	447	31	systemic	systemic	JJ
cord-267897-w4pbq2lb	447	32	reactions	reaction	NNS
cord-267897-w4pbq2lb	447	33	of	of	IN
cord-267897-w4pbq2lb	447	34	lipopolysaccharides	lipopolysaccharide	NNS
cord-267897-w4pbq2lb	447	35	in	in	IN
cord-267897-w4pbq2lb	447	36	swine	swine	NN
cord-267897-w4pbq2lb	447	37	Central	central	JJ
cord-267897-w4pbq2lb	447	38	nervous	nervous	JJ
cord-267897-w4pbq2lb	447	39	system	system	NN
cord-267897-w4pbq2lb	447	40	disease	disease	NN
cord-267897-w4pbq2lb	447	41	in	in	IN
cord-267897-w4pbq2lb	447	42	patients	patient	NNS
cord-267897-w4pbq2lb	447	43	with	with	IN
cord-267897-w4pbq2lb	447	44	macrophagic	macrophagic	JJ
cord-267897-w4pbq2lb	447	45	myofasciitis	myofasciitis	NNP
cord-267897-w4pbq2lb	448	1	The	the	DT
cord-267897-w4pbq2lb	448	2	artwork	artwork	NN
cord-267897-w4pbq2lb	448	3	in	in	IN
cord-267897-w4pbq2lb	448	4	Fig	Fig	NNP
cord-267897-w4pbq2lb	448	5	.	.	.
cord-267897-w4pbq2lb	449	1	18	18	CD
cord-267897-w4pbq2lb	449	2	 	 	_SP