id sid tid token lemma pos cord-257899-l866puqk 1 1 key key JJ cord-257899-l866puqk 1 2 : : : cord-257899-l866puqk 1 3 cord-257899-l866puqk cord-257899-l866puqk JJ cord-257899-l866puqk 1 4 authors author NNS cord-257899-l866puqk 1 5 : : : cord-257899-l866puqk 1 6 Yun Yun NNP cord-257899-l866puqk 1 7 , , , cord-257899-l866puqk 1 8 Cheol Cheol NNP cord-257899-l866puqk 1 9 - - HYPH cord-257899-l866puqk 1 10 Heui Heui NNP cord-257899-l866puqk 1 11 ; ; . cord-257899-l866puqk 2 1 Cho Cho NNP cord-257899-l866puqk 2 2 , , , cord-257899-l866puqk 2 3 Chong Chong NNP cord-257899-l866puqk 2 4 - - HYPH cord-257899-l866puqk 2 5 Su Su NNP cord-257899-l866puqk 2 6 title title NN cord-257899-l866puqk 2 7 : : : cord-257899-l866puqk 2 8 Nanoparticles nanoparticle NNS cord-257899-l866puqk 2 9 to to TO cord-257899-l866puqk 2 10 Improve improve VB cord-257899-l866puqk 2 11 the the DT cord-257899-l866puqk 2 12 Efficacy Efficacy NNP cord-257899-l866puqk 2 13 of of IN cord-257899-l866puqk 2 14 Vaccines Vaccines NNPS cord-257899-l866puqk 2 15 date date NN cord-257899-l866puqk 3 1 : : : cord-257899-l866puqk 3 2 2020 2020 CD cord-257899-l866puqk 3 3 - - HYPH cord-257899-l866puqk 3 4 05 05 CD cord-257899-l866puqk 3 5 - - HYPH cord-257899-l866puqk 3 6 02 02 CD cord-257899-l866puqk 3 7 journal journal NN cord-257899-l866puqk 3 8 : : : cord-257899-l866puqk 4 1 Pharmaceutics Pharmaceutics NNP cord-257899-l866puqk 4 2 DOI DOI NNP cord-257899-l866puqk 4 3 : : : cord-257899-l866puqk 5 1 10.3390 10.3390 CD cord-257899-l866puqk 5 2 / / SYM cord-257899-l866puqk 5 3 pharmaceutics12050418 pharmaceutics12050418 NNP cord-257899-l866puqk 5 4 sha sha NNP cord-257899-l866puqk 5 5 : : : cord-257899-l866puqk 5 6 7274c95584f2d0f9010edc6c02a89e323a6ee1b0 7274c95584f2d0f9010edc6c02a89e323a6ee1b0 CD cord-257899-l866puqk 5 7 doc_id doc_id CD cord-257899-l866puqk 6 1 : : : cord-257899-l866puqk 6 2 257899 257899 CD cord-257899-l866puqk 6 3 cord_uid cord_uid NNS cord-257899-l866puqk 6 4 : : : cord-257899-l866puqk 7 1 l866puqk l866puqk NNP cord-257899-l866puqk 8 1 This this DT cord-257899-l866puqk 8 2 editorial editorial NN cord-257899-l866puqk 8 3 aims aim VBZ cord-257899-l866puqk 8 4 to to TO cord-257899-l866puqk 8 5 summarize summarize VB cord-257899-l866puqk 8 6 the the DT cord-257899-l866puqk 8 7 nine nine CD cord-257899-l866puqk 8 8 scientific scientific JJ cord-257899-l866puqk 8 9 papers paper NNS cord-257899-l866puqk 8 10 that that WDT cord-257899-l866puqk 8 11 contributed contribute VBD cord-257899-l866puqk 8 12 to to IN cord-257899-l866puqk 8 13 the the DT cord-257899-l866puqk 8 14 Special Special NNP cord-257899-l866puqk 8 15 Issue Issue NNP cord-257899-l866puqk 8 16 entitled entitle VBN cord-257899-l866puqk 8 17 ‘ ' `` cord-257899-l866puqk 8 18 Nanoparticles nanoparticle NNS cord-257899-l866puqk 8 19 to to TO cord-257899-l866puqk 8 20 Improve improve VB cord-257899-l866puqk 8 21 the the DT cord-257899-l866puqk 8 22 Efficacy Efficacy NNP cord-257899-l866puqk 8 23 of of IN cord-257899-l866puqk 8 24 Vaccines Vaccines NNPS cord-257899-l866puqk 8 25 ’ ' '' cord-257899-l866puqk 8 26 . . . cord-257899-l866puqk 9 1 A a DT cord-257899-l866puqk 9 2 vaccine vaccine NN cord-257899-l866puqk 9 3 , , , cord-257899-l866puqk 9 4 providing provide VBG cord-257899-l866puqk 9 5 active active JJ cord-257899-l866puqk 9 6 and and CC cord-257899-l866puqk 9 7 protective protective JJ cord-257899-l866puqk 9 8 immunity immunity NN cord-257899-l866puqk 9 9 against against IN cord-257899-l866puqk 9 10 a a DT cord-257899-l866puqk 9 11 target target NN cord-257899-l866puqk 9 12 disease disease NN cord-257899-l866puqk 9 13 , , , cord-257899-l866puqk 9 14 contains contain VBZ cord-257899-l866puqk 9 15 an an DT cord-257899-l866puqk 9 16 agent agent NN cord-257899-l866puqk 9 17 that that WDT cord-257899-l866puqk 9 18 originated originate VBD cord-257899-l866puqk 9 19 from from IN cord-257899-l866puqk 9 20 and/or and/or CC cord-257899-l866puqk 9 21 resembles resemble VBZ cord-257899-l866puqk 9 22 a a DT cord-257899-l866puqk 9 23 disease disease NN cord-257899-l866puqk 9 24 - - HYPH cord-257899-l866puqk 9 25 causing cause VBG cord-257899-l866puqk 9 26 microorganism microorganism NN cord-257899-l866puqk 9 27 . . . cord-257899-l866puqk 10 1 It -PRON- PRP cord-257899-l866puqk 10 2 is be VBZ cord-257899-l866puqk 10 3 often often RB cord-257899-l866puqk 10 4 made make VBN cord-257899-l866puqk 10 5 from from IN cord-257899-l866puqk 10 6 a a DT cord-257899-l866puqk 10 7 weakened weaken VBN cord-257899-l866puqk 10 8 or or CC cord-257899-l866puqk 10 9 inactivated inactivate VBN cord-257899-l866puqk 10 10 microbe microbe NN cord-257899-l866puqk 10 11 , , , cord-257899-l866puqk 10 12 its -PRON- PRP$ cord-257899-l866puqk 10 13 toxins toxin NNS cord-257899-l866puqk 10 14 , , , cord-257899-l866puqk 10 15 or or CC cord-257899-l866puqk 10 16 one one CD cord-257899-l866puqk 10 17 of of IN cord-257899-l866puqk 10 18 its -PRON- PRP$ cord-257899-l866puqk 10 19 nucleotides nucleotide NNS cord-257899-l866puqk 10 20 , , , cord-257899-l866puqk 10 21 peptides peptide NNS cord-257899-l866puqk 10 22 or or CC cord-257899-l866puqk 10 23 proteins protein NNS cord-257899-l866puqk 10 24 . . . cord-257899-l866puqk 11 1 Vaccines vaccine NNS cord-257899-l866puqk 11 2 can can MD cord-257899-l866puqk 11 3 be be VB cord-257899-l866puqk 11 4 prophylactic prophylactic JJ cord-257899-l866puqk 11 5 to to TO cord-257899-l866puqk 11 6 ameliorate ameliorate VB cord-257899-l866puqk 11 7 or or CC cord-257899-l866puqk 11 8 better well RBR cord-257899-l866puqk 11 9 prevent prevent VB cord-257899-l866puqk 11 10 the the DT cord-257899-l866puqk 11 11 effects effect NNS cord-257899-l866puqk 11 12 of of IN cord-257899-l866puqk 11 13 a a DT cord-257899-l866puqk 11 14 wild wild JJ cord-257899-l866puqk 11 15 - - HYPH cord-257899-l866puqk 11 16 type type NN cord-257899-l866puqk 11 17 pathogen pathogen NN cord-257899-l866puqk 11 18 , , , cord-257899-l866puqk 11 19 or or CC cord-257899-l866puqk 11 20 therapeutic therapeutic JJ cord-257899-l866puqk 11 21 against against IN cord-257899-l866puqk 11 22 likely likely JJ cord-257899-l866puqk 11 23 cancers cancer NNS cord-257899-l866puqk 11 24 . . . cord-257899-l866puqk 12 1 To to IN cord-257899-l866puqk 12 2 date date NN cord-257899-l866puqk 12 3 , , , cord-257899-l866puqk 12 4 the the DT cord-257899-l866puqk 12 5 World World NNP cord-257899-l866puqk 12 6 Health Health NNP cord-257899-l866puqk 12 7 Organization Organization NNP cord-257899-l866puqk 12 8 lists list VBZ cord-257899-l866puqk 12 9 twenty twenty CD cord-257899-l866puqk 12 10 - - HYPH cord-257899-l866puqk 12 11 seven seven CD cord-257899-l866puqk 12 12 preventable preventable JJ cord-257899-l866puqk 12 13 infections infection NNS cord-257899-l866puqk 12 14 for for IN cord-257899-l866puqk 12 15 which which WDT cord-257899-l866puqk 12 16 vaccines vaccine NNS cord-257899-l866puqk 12 17 are be VBP cord-257899-l866puqk 12 18 available available JJ cord-257899-l866puqk 12 19 [ [ -LRB- cord-257899-l866puqk 12 20 1 1 CD cord-257899-l866puqk 12 21 ] ] -RRB- cord-257899-l866puqk 12 22 -far -far : cord-257899-l866puqk 12 23 less less JJR cord-257899-l866puqk 12 24 than than IN cord-257899-l866puqk 12 25 what what WP cord-257899-l866puqk 12 26 our -PRON- PRP$ cord-257899-l866puqk 12 27 society society NN cord-257899-l866puqk 12 28 needs need VBZ cord-257899-l866puqk 12 29 . . . cord-257899-l866puqk 13 1 Vaccination vaccination NN cord-257899-l866puqk 13 2 , , , cord-257899-l866puqk 13 3 a a DT cord-257899-l866puqk 13 4 process process NN cord-257899-l866puqk 13 5 of of IN cord-257899-l866puqk 13 6 introducing introduce VBG cord-257899-l866puqk 13 7 foreign foreign JJ cord-257899-l866puqk 13 8 antigenic antigenic JJ cord-257899-l866puqk 13 9 material(s material(s NN cord-257899-l866puqk 13 10 ) ) -RRB- cord-257899-l866puqk 13 11 in in IN cord-257899-l866puqk 13 12 order order NN cord-257899-l866puqk 13 13 to to TO cord-257899-l866puqk 13 14 activate activate VB cord-257899-l866puqk 13 15 a a DT cord-257899-l866puqk 13 16 host host NN cord-257899-l866puqk 13 17 immune immune JJ cord-257899-l866puqk 13 18 system system NN cord-257899-l866puqk 13 19 , , , cord-257899-l866puqk 13 20 has have VBZ cord-257899-l866puqk 13 21 been be VBN cord-257899-l866puqk 13 22 a a DT cord-257899-l866puqk 13 23 key key JJ cord-257899-l866puqk 13 24 strategy strategy NN cord-257899-l866puqk 13 25 to to TO cord-257899-l866puqk 13 26 control control VB cord-257899-l866puqk 13 27 diseases disease NNS cord-257899-l866puqk 13 28 and and CC cord-257899-l866puqk 13 29 improve improve VB cord-257899-l866puqk 13 30 quality quality NN cord-257899-l866puqk 13 31 of of IN cord-257899-l866puqk 13 32 life life NN cord-257899-l866puqk 13 33 in in IN cord-257899-l866puqk 13 34 humans human NNS cord-257899-l866puqk 13 35 and and CC cord-257899-l866puqk 13 36 animals animal NNS cord-257899-l866puqk 13 37 . . . cord-257899-l866puqk 14 1 Despite despite IN cord-257899-l866puqk 14 2 the the DT cord-257899-l866puqk 14 3 presence presence NN cord-257899-l866puqk 14 4 of of IN cord-257899-l866puqk 14 5 some some DT cord-257899-l866puqk 14 6 successful successful JJ cord-257899-l866puqk 14 7 vaccines vaccine NNS cord-257899-l866puqk 14 8 , , , cord-257899-l866puqk 14 9 many many JJ cord-257899-l866puqk 14 10 novel novel NN cord-257899-l866puqk 14 11 and and CC cord-257899-l866puqk 14 12 modified modified JJ cord-257899-l866puqk 14 13 diseases disease NNS cord-257899-l866puqk 14 14 including include VBG cord-257899-l866puqk 14 15 Ebola Ebola NNP cord-257899-l866puqk 14 16 virus virus NN cord-257899-l866puqk 14 17 disease disease NN cord-257899-l866puqk 14 18 , , , cord-257899-l866puqk 14 19 Zika Zika NNP cord-257899-l866puqk 14 20 virus virus NN cord-257899-l866puqk 14 21 disease disease NN cord-257899-l866puqk 14 22 , , , cord-257899-l866puqk 14 23 coronavirus coronavirus NN cord-257899-l866puqk 14 24 diseases disease NNS cord-257899-l866puqk 14 25 [ [ -LRB- cord-257899-l866puqk 14 26 middle middle JJ cord-257899-l866puqk 14 27 eastern eastern JJ cord-257899-l866puqk 14 28 respiratory respiratory JJ cord-257899-l866puqk 14 29 syndrome syndrome NN cord-257899-l866puqk 14 30 coronavirus coronavirus NN cord-257899-l866puqk 14 31 ( ( -LRB- cord-257899-l866puqk 14 32 MERS MERS NNP cord-257899-l866puqk 14 33 - - HYPH cord-257899-l866puqk 14 34 CoV CoV NNP cord-257899-l866puqk 14 35 ) ) -RRB- cord-257899-l866puqk 14 36 , , , cord-257899-l866puqk 14 37 severe severe JJ cord-257899-l866puqk 14 38 acute acute JJ cord-257899-l866puqk 14 39 respiratory respiratory JJ cord-257899-l866puqk 14 40 syndrome syndrome NN cord-257899-l866puqk 14 41 coronavirus coronavirus NN cord-257899-l866puqk 14 42 ( ( -LRB- cord-257899-l866puqk 14 43 SARS SARS NNP cord-257899-l866puqk 14 44 - - HYPH cord-257899-l866puqk 14 45 CoV CoV NNP cord-257899-l866puqk 14 46 ) ) -RRB- cord-257899-l866puqk 14 47 , , , cord-257899-l866puqk 14 48 and and CC cord-257899-l866puqk 14 49 2019 2019 CD cord-257899-l866puqk 14 50 novel novel JJ cord-257899-l866puqk 14 51 coronavirus coronavirus NN cord-257899-l866puqk 14 52 ( ( -LRB- cord-257899-l866puqk 14 53 2019-nCoV 2019-ncov CD cord-257899-l866puqk 14 54 ) ) -RRB- cord-257899-l866puqk 14 55 ] ] -RRB- cord-257899-l866puqk 14 56 , , , cord-257899-l866puqk 14 57 dengue dengue NN cord-257899-l866puqk 14 58 fever fever NN cord-257899-l866puqk 14 59 , , , cord-257899-l866puqk 14 60 Marburg Marburg NNP cord-257899-l866puqk 14 61 disease disease NN cord-257899-l866puqk 14 62 , , , cord-257899-l866puqk 14 63 malaria malaria NN cord-257899-l866puqk 14 64 , , , cord-257899-l866puqk 14 65 and and CC cord-257899-l866puqk 14 66 tuberculosis tuberculosis NN cord-257899-l866puqk 14 67 are be VBP cord-257899-l866puqk 14 68 in in IN cord-257899-l866puqk 14 69 need need NN cord-257899-l866puqk 14 70 of of IN cord-257899-l866puqk 14 71 effective effective JJ cord-257899-l866puqk 14 72 vaccines vaccine NNS cord-257899-l866puqk 14 73 together together RB cord-257899-l866puqk 14 74 with with IN cord-257899-l866puqk 14 75 qualified qualified JJ cord-257899-l866puqk 14 76 adjuvants adjuvant NNS cord-257899-l866puqk 14 77 . . . cord-257899-l866puqk 15 1 While while IN cord-257899-l866puqk 15 2 traditional traditional JJ cord-257899-l866puqk 15 3 adjuvants adjuvant NNS cord-257899-l866puqk 15 4 such such JJ cord-257899-l866puqk 15 5 as as IN cord-257899-l866puqk 15 6 alum alum NN cord-257899-l866puqk 15 7 have have VBP cord-257899-l866puqk 15 8 been be VBN cord-257899-l866puqk 15 9 exclusively exclusively RB cord-257899-l866puqk 15 10 employed employ VBN cord-257899-l866puqk 15 11 clinically clinically RB cord-257899-l866puqk 15 12 to to TO cord-257899-l866puqk 15 13 promote promote VB cord-257899-l866puqk 15 14 humoral humoral JJ cord-257899-l866puqk 15 15 responses response NNS cord-257899-l866puqk 15 16 , , , cord-257899-l866puqk 15 17 recent recent JJ cord-257899-l866puqk 15 18 developments development NNS cord-257899-l866puqk 15 19 in in IN cord-257899-l866puqk 15 20 adjuvant adjuvant JJ cord-257899-l866puqk 15 21 research research NN cord-257899-l866puqk 15 22 have have VBP cord-257899-l866puqk 15 23 identified identify VBN cord-257899-l866puqk 15 24 molecules molecule NNS cord-257899-l866puqk 15 25 , , , cord-257899-l866puqk 15 26 which which WDT cord-257899-l866puqk 15 27 are be VBP cord-257899-l866puqk 15 28 pathogen pathogen NN cord-257899-l866puqk 15 29 - - HYPH cord-257899-l866puqk 15 30 associated associate VBN cord-257899-l866puqk 15 31 molecular molecular JJ cord-257899-l866puqk 15 32 patterns pattern NNS cord-257899-l866puqk 15 33 , , , cord-257899-l866puqk 15 34 a a DT cord-257899-l866puqk 15 35 few few JJ cord-257899-l866puqk 15 36 chemical chemical NN cord-257899-l866puqk 15 37 compounds compound NNS cord-257899-l866puqk 15 38 , , , cord-257899-l866puqk 15 39 and and CC cord-257899-l866puqk 15 40 agonists agonist NNS cord-257899-l866puqk 15 41 of of IN cord-257899-l866puqk 15 42 toll toll NN cord-257899-l866puqk 15 43 - - HYPH cord-257899-l866puqk 15 44 like like JJ cord-257899-l866puqk 15 45 receptors receptor NNS cord-257899-l866puqk 15 46 , , , cord-257899-l866puqk 15 47 all all DT cord-257899-l866puqk 15 48 of of IN cord-257899-l866puqk 15 49 which which WDT cord-257899-l866puqk 15 50 induce induce VBP cord-257899-l866puqk 15 51 strong strong JJ cord-257899-l866puqk 15 52 immune immune JJ cord-257899-l866puqk 15 53 responses response NNS cord-257899-l866puqk 15 54 . . . cord-257899-l866puqk 16 1 With with IN cord-257899-l866puqk 16 2 great great JJ cord-257899-l866puqk 16 3 advancements advancement NNS cord-257899-l866puqk 16 4 in in IN cord-257899-l866puqk 16 5 the the DT cord-257899-l866puqk 16 6 area area NN cord-257899-l866puqk 16 7 of of IN cord-257899-l866puqk 16 8 material material NN cord-257899-l866puqk 16 9 science science NN cord-257899-l866puqk 16 10 , , , cord-257899-l866puqk 16 11 a a DT cord-257899-l866puqk 16 12 new new JJ cord-257899-l866puqk 16 13 era era NN cord-257899-l866puqk 16 14 of of IN cord-257899-l866puqk 16 15 innovative innovative JJ cord-257899-l866puqk 16 16 strategies strategy NNS cord-257899-l866puqk 16 17 for for IN cord-257899-l866puqk 16 18 vaccine vaccine NN cord-257899-l866puqk 16 19 design design NN cord-257899-l866puqk 16 20 has have VBZ cord-257899-l866puqk 16 21 arrived arrive VBN cord-257899-l866puqk 16 22 , , , cord-257899-l866puqk 16 23 enabling enable VBG cord-257899-l866puqk 16 24 the the DT cord-257899-l866puqk 16 25 precise precise JJ cord-257899-l866puqk 16 26 delivery delivery NN cord-257899-l866puqk 16 27 of of IN cord-257899-l866puqk 16 28 vaccines vaccine NNS cord-257899-l866puqk 16 29 , , , cord-257899-l866puqk 16 30 the the DT cord-257899-l866puqk 16 31 enhanced enhanced JJ cord-257899-l866puqk 16 32 role role NN cord-257899-l866puqk 16 33 of of IN cord-257899-l866puqk 16 34 vaccine vaccine NN cord-257899-l866puqk 16 35 adjuvants adjuvant NNS cord-257899-l866puqk 16 36 , , , cord-257899-l866puqk 16 37 an an DT cord-257899-l866puqk 16 38 increase increase NN cord-257899-l866puqk 16 39 in in IN cord-257899-l866puqk 16 40 the the DT cord-257899-l866puqk 16 41 sparing sparing NN cord-257899-l866puqk 16 42 effect effect NN cord-257899-l866puqk 16 43 , , , cord-257899-l866puqk 16 44 better well JJR cord-257899-l866puqk 16 45 stabilization stabilization NN cord-257899-l866puqk 16 46 , , , cord-257899-l866puqk 16 47 and and CC cord-257899-l866puqk 16 48 slow slow JJ cord-257899-l866puqk 16 49 release release NN cord-257899-l866puqk 16 50 at at IN cord-257899-l866puqk 16 51 the the DT cord-257899-l866puqk 16 52 induction induction NN cord-257899-l866puqk 16 53 site site NN cord-257899-l866puqk 16 54 . . . cord-257899-l866puqk 17 1 Nanomaterials Nanomaterials NNP cord-257899-l866puqk 17 2 that that WDT cord-257899-l866puqk 17 3 modified modify VBD cord-257899-l866puqk 17 4 to to TO cord-257899-l866puqk 17 5 trigger trigger VB cord-257899-l866puqk 17 6 antigen antigen NN cord-257899-l866puqk 17 7 - - HYPH cord-257899-l866puqk 17 8 specific specific JJ cord-257899-l866puqk 17 9 immune immune JJ cord-257899-l866puqk 17 10 responses response NNS cord-257899-l866puqk 17 11 could could MD cord-257899-l866puqk 17 12 be be VB cord-257899-l866puqk 17 13 categorized categorize VBN cord-257899-l866puqk 17 14 into into IN cord-257899-l866puqk 17 15 liposomes liposome NNS cord-257899-l866puqk 17 16 and and CC cord-257899-l866puqk 17 17 lipid lipid NN cord-257899-l866puqk 17 18 - - HYPH cord-257899-l866puqk 17 19 based base VBN cord-257899-l866puqk 17 20 nanoparticles nanoparticle NNS cord-257899-l866puqk 17 21 , , , cord-257899-l866puqk 17 22 polymeric polymeric JJ cord-257899-l866puqk 17 23 nanoparticles nanoparticle NNS cord-257899-l866puqk 17 24 , , , cord-257899-l866puqk 17 25 gold gold NN cord-257899-l866puqk 17 26 nanoparticles nanoparticle NNS cord-257899-l866puqk 17 27 , , , cord-257899-l866puqk 17 28 inorganic inorganic JJ cord-257899-l866puqk 17 29 nanoparticles nanoparticle NNS cord-257899-l866puqk 17 30 , , , cord-257899-l866puqk 17 31 virus virus NN cord-257899-l866puqk 17 32 - - HYPH cord-257899-l866puqk 17 33 like like JJ cord-257899-l866puqk 17 34 particles particle NNS cord-257899-l866puqk 17 35 , , , cord-257899-l866puqk 17 36 self self NN cord-257899-l866puqk 17 37 - - HYPH cord-257899-l866puqk 17 38 assembled assemble VBN cord-257899-l866puqk 17 39 proteins protein NNS cord-257899-l866puqk 17 40 , , , cord-257899-l866puqk 17 41 and and CC cord-257899-l866puqk 17 42 carbon carbon NN cord-257899-l866puqk 17 43 - - HYPH cord-257899-l866puqk 17 44 based base VBN cord-257899-l866puqk 17 45 nanoparticles nanoparticle NNS cord-257899-l866puqk 17 46 ( ( -LRB- cord-257899-l866puqk 17 47 carbon carbon NN cord-257899-l866puqk 17 48 nanotubes nanotube NNS cord-257899-l866puqk 17 49 and and CC cord-257899-l866puqk 17 50 graphenes graphene NNS cord-257899-l866puqk 17 51 ) ) -RRB- cord-257899-l866puqk 17 52 . . . cord-257899-l866puqk 18 1 In in IN cord-257899-l866puqk 18 2 the the DT cord-257899-l866puqk 18 3 Special Special NNP cord-257899-l866puqk 18 4 Issue Issue NNP cord-257899-l866puqk 18 5 , , , cord-257899-l866puqk 18 6 entitled entitle VBN cord-257899-l866puqk 18 7 ' ' `` cord-257899-l866puqk 18 8 Nanoparticles nanoparticle NNS cord-257899-l866puqk 18 9 to to TO cord-257899-l866puqk 18 10 Improve improve VB cord-257899-l866puqk 18 11 the the DT cord-257899-l866puqk 18 12 Efficacy Efficacy NNP cord-257899-l866puqk 18 13 of of IN cord-257899-l866puqk 18 14 Vaccine Vaccine NNP cord-257899-l866puqk 18 15 ' ' '' cord-257899-l866puqk 18 16 in in IN cord-257899-l866puqk 18 17 the the DT cord-257899-l866puqk 18 18 Pharmaceutics Pharmaceutics NNP cord-257899-l866puqk 18 19 ( ( -LRB- cord-257899-l866puqk 18 20 https://www.mdpi.com/journal/pharmaceutics/special https://www.mdpi.com/journal/pharmaceutics/special JJ cord-257899-l866puqk 19 1 _ _ NNP cord-257899-l866puqk 19 2 issues issue NNS cord-257899-l866puqk 19 3 / / SYM cord-257899-l866puqk 19 4 Nanoparticles_Vaccines nanoparticles_vaccines CD cord-257899-l866puqk 19 5 ) ) -RRB- cord-257899-l866puqk 20 1 , , , cord-257899-l866puqk 20 2 we -PRON- PRP cord-257899-l866puqk 20 3 draw draw VBP cord-257899-l866puqk 20 4 attention attention NN cord-257899-l866puqk 20 5 to to IN cord-257899-l866puqk 20 6 the the DT cord-257899-l866puqk 20 7 advanced advanced JJ cord-257899-l866puqk 20 8 platforms platform NNS cord-257899-l866puqk 20 9 and and CC cord-257899-l866puqk 20 10 technologies technology NNS cord-257899-l866puqk 20 11 using use VBG cord-257899-l866puqk 20 12 nanomaterials nanomaterial NNS cord-257899-l866puqk 20 13 in in IN cord-257899-l866puqk 20 14 order order NN cord-257899-l866puqk 20 15 to to TO cord-257899-l866puqk 20 16 produce produce VB cord-257899-l866puqk 20 17 the the DT cord-257899-l866puqk 20 18 best good JJS cord-257899-l866puqk 20 19 outcomes outcome NNS cord-257899-l866puqk 20 20 in in IN cord-257899-l866puqk 20 21 terms term NNS cord-257899-l866puqk 20 22 of of IN cord-257899-l866puqk 20 23 vaccination vaccination NN cord-257899-l866puqk 20 24 and and CC cord-257899-l866puqk 20 25 immunological immunological JJ cord-257899-l866puqk 20 26 memory memory NN cord-257899-l866puqk 20 27 . . . cord-257899-l866puqk 21 1 Kim Kim NNP cord-257899-l866puqk 21 2 et et NNP cord-257899-l866puqk 21 3 al al NNP cord-257899-l866puqk 21 4 . . . cord-257899-l866puqk 22 1 [ [ -LRB- cord-257899-l866puqk 22 2 2 2 CD cord-257899-l866puqk 22 3 ] ] -RRB- cord-257899-l866puqk 22 4 described describe VBD cord-257899-l866puqk 22 5 a a DT cord-257899-l866puqk 22 6 method method NN cord-257899-l866puqk 22 7 to to TO cord-257899-l866puqk 22 8 improve improve VB cord-257899-l866puqk 22 9 the the DT cord-257899-l866puqk 22 10 battle battle NN cord-257899-l866puqk 22 11 against against IN cord-257899-l866puqk 22 12 intracellular intracellular JJ cord-257899-l866puqk 22 13 bacterial bacterial JJ cord-257899-l866puqk 22 14 or or CC cord-257899-l866puqk 22 15 viral viral JJ cord-257899-l866puqk 22 16 infections infection NNS cord-257899-l866puqk 22 17 , , , cord-257899-l866puqk 22 18 and and CC cord-257899-l866puqk 22 19 malignant malignant JJ cord-257899-l866puqk 22 20 tumors tumor NNS cord-257899-l866puqk 22 21 by by IN cord-257899-l866puqk 22 22 various various JJ cord-257899-l866puqk 22 23 vaccination vaccination NN cord-257899-l866puqk 22 24 schemes scheme NNS cord-257899-l866puqk 22 25 , , , cord-257899-l866puqk 22 26 using use VBG cord-257899-l866puqk 22 27 physicochemical physicochemical JJ cord-257899-l866puqk 22 28 characteristics characteristic NNS cord-257899-l866puqk 22 29 that that WDT cord-257899-l866puqk 22 30 target target VBP cord-257899-l866puqk 22 31 antigen antigen NN cord-257899-l866puqk 22 32 - - HYPH cord-257899-l866puqk 22 33 presenting present VBG cord-257899-l866puqk 22 34 cells cell NNS cord-257899-l866puqk 22 35 ( ( -LRB- cord-257899-l866puqk 22 36 APCs apc NNS cord-257899-l866puqk 22 37 ) ) -RRB- cord-257899-l866puqk 22 38 . . . cord-257899-l866puqk 23 1 In in IN cord-257899-l866puqk 23 2 particular particular JJ cord-257899-l866puqk 23 3 , , , cord-257899-l866puqk 23 4 the the DT cord-257899-l866puqk 23 5 improvement improvement NN cord-257899-l866puqk 23 6 of of IN cord-257899-l866puqk 23 7 an an DT cord-257899-l866puqk 23 8 unconventional unconventional JJ cord-257899-l866puqk 23 9 type type NN cord-257899-l866puqk 23 10 of of IN cord-257899-l866puqk 23 11 antigen antigen NN cord-257899-l866puqk 23 12 presentation presentation NN cord-257899-l866puqk 23 13 , , , cord-257899-l866puqk 23 14 called call VBD cord-257899-l866puqk 23 15 ' ' `` cord-257899-l866puqk 23 16 cross cross JJ cord-257899-l866puqk 23 17 - - JJ cord-257899-l866puqk 23 18 presentation presentation NN cord-257899-l866puqk 23 19 ' ' '' cord-257899-l866puqk 23 20 in in IN cord-257899-l866puqk 23 21 APCs apc NNS cord-257899-l866puqk 23 22 when when WRB cord-257899-l866puqk 23 23 treated treat VBN cord-257899-l866puqk 23 24 with with IN cord-257899-l866puqk 23 25 certain certain JJ cord-257899-l866puqk 23 26 nanomaterials nanomaterial NNS cord-257899-l866puqk 23 27 for for IN cord-257899-l866puqk 23 28 antigen antigen NN cord-257899-l866puqk 23 29 - - HYPH cord-257899-l866puqk 23 30 specific specific JJ cord-257899-l866puqk 23 31 CD8 CD8 NNP cord-257899-l866puqk 23 32 + + CC cord-257899-l866puqk 23 33 T t NN cord-257899-l866puqk 23 34 cell cell NN cord-257899-l866puqk 23 35 responses response NNS cord-257899-l866puqk 23 36 , , , cord-257899-l866puqk 23 37 was be VBD cord-257899-l866puqk 23 38 discussed discuss VBN cord-257899-l866puqk 23 39 [ [ -LRB- cord-257899-l866puqk 23 40 3 3 CD cord-257899-l866puqk 23 41 ] ] -RRB- cord-257899-l866puqk 23 42 . . . cord-257899-l866puqk 24 1 The the DT cord-257899-l866puqk 24 2 authors author NNS cord-257899-l866puqk 24 3 focused focus VBD cord-257899-l866puqk 24 4 on on IN cord-257899-l866puqk 24 5 the the DT cord-257899-l866puqk 24 6 mechanisms mechanism NNS cord-257899-l866puqk 24 7 of of IN cord-257899-l866puqk 24 8 two two CD cord-257899-l866puqk 24 9 major major JJ cord-257899-l866puqk 24 10 intracellular intracellular JJ cord-257899-l866puqk 24 11 pathways pathway NNS cord-257899-l866puqk 24 12 that that WDT cord-257899-l866puqk 24 13 nano nano NN cord-257899-l866puqk 24 14 - - HYPH cord-257899-l866puqk 24 15 sized sized JJ cord-257899-l866puqk 24 16 vaccines vaccine NNS cord-257899-l866puqk 24 17 harness harness VBP cord-257899-l866puqk 24 18 for for IN cord-257899-l866puqk 24 19 cross cross NN cord-257899-l866puqk 24 20 - - NN cord-257899-l866puqk 24 21 presentation presentation NN cord-257899-l866puqk 24 22 , , , cord-257899-l866puqk 24 23 namely namely RB cord-257899-l866puqk 24 24 endosomal endosomal VBG cord-257899-l866puqk 24 25 swelling swell VBG cord-257899-l866puqk 24 26 and and CC cord-257899-l866puqk 24 27 rupture rupture NN cord-257899-l866puqk 24 28 , , , cord-257899-l866puqk 24 29 and and CC cord-257899-l866puqk 24 30 membrane membrane NN cord-257899-l866puqk 24 31 fusion fusion NN cord-257899-l866puqk 24 32 . . . cord-257899-l866puqk 25 1 These these DT cord-257899-l866puqk 25 2 processes process NNS cord-257899-l866puqk 25 3 allow allow VBP cord-257899-l866puqk 25 4 exogenous exogenous JJ cord-257899-l866puqk 25 5 antigens antigen NNS cord-257899-l866puqk 25 6 exported export VBN cord-257899-l866puqk 25 7 from from IN cord-257899-l866puqk 25 8 phagosomes phagosome NNS cord-257899-l866puqk 25 9 into into IN cord-257899-l866puqk 25 10 the the DT cord-257899-l866puqk 25 11 cytosol cytosol NN cord-257899-l866puqk 25 12 , , , cord-257899-l866puqk 25 13 followed follow VBN cord-257899-l866puqk 25 14 by by IN cord-257899-l866puqk 25 15 loading load VBG cord-257899-l866puqk 25 16 on on IN cord-257899-l866puqk 25 17 major major JJ cord-257899-l866puqk 25 18 histocompatibility histocompatibility NN cord-257899-l866puqk 25 19 complex complex NN cord-257899-l866puqk 25 20 ( ( -LRB- cord-257899-l866puqk 25 21 MHC MHC NNP cord-257899-l866puqk 25 22 ) ) -RRB- cord-257899-l866puqk 25 23 class class NN cord-257899-l866puqk 25 24 I i NN cord-257899-l866puqk 25 25 , , , cord-257899-l866puqk 25 26 triggering trigger VBG cord-257899-l866puqk 25 27 the the DT cord-257899-l866puqk 25 28 clonal clonal JJ cord-257899-l866puqk 25 29 expansion expansion NN cord-257899-l866puqk 25 30 of of IN cord-257899-l866puqk 25 31 antigen antigen NN cord-257899-l866puqk 25 32 - - HYPH cord-257899-l866puqk 25 33 specific specific JJ cord-257899-l866puqk 25 34 CD8 CD8 NNP cord-257899-l866puqk 25 35 + + CC cord-257899-l866puqk 25 36 T t NN cord-257899-l866puqk 25 37 cells cell NNS cord-257899-l866puqk 25 38 . . . cord-257899-l866puqk 26 1 Barnowski Barnowski NNP cord-257899-l866puqk 26 2 et et NNP cord-257899-l866puqk 26 3 al al NNP cord-257899-l866puqk 26 4 . . . cord-257899-l866puqk 27 1 [ [ -LRB- cord-257899-l866puqk 27 2 4 4 CD cord-257899-l866puqk 27 3 ] ] -RRB- cord-257899-l866puqk 27 4 discussed discuss VBN cord-257899-l866puqk 27 5 nano nano NN cord-257899-l866puqk 27 6 - - HYPH cord-257899-l866puqk 27 7 vaccines vaccine NNS cord-257899-l866puqk 27 8 in in IN cord-257899-l866puqk 27 9 the the DT cord-257899-l866puqk 27 10 form form NN cord-257899-l866puqk 27 11 of of IN cord-257899-l866puqk 27 12 virus virus NN cord-257899-l866puqk 27 13 - - HYPH cord-257899-l866puqk 27 14 like like JJ cord-257899-l866puqk 27 15 particles particle NNS cord-257899-l866puqk 27 16 ( ( -LRB- cord-257899-l866puqk 27 17 VLPs VLPs NNP cord-257899-l866puqk 27 18 ) ) -RRB- cord-257899-l866puqk 27 19 , , , cord-257899-l866puqk 27 20 which which WDT cord-257899-l866puqk 27 21 share share VBP cord-257899-l866puqk 27 22 structural structural JJ cord-257899-l866puqk 27 23 identities identity NNS cord-257899-l866puqk 27 24 with with IN cord-257899-l866puqk 27 25 their -PRON- PRP$ cord-257899-l866puqk 27 26 wild wild JJ cord-257899-l866puqk 27 27 - - HYPH cord-257899-l866puqk 27 28 type type NN cord-257899-l866puqk 27 29 viruses virus NNS cord-257899-l866puqk 27 30 , , , cord-257899-l866puqk 27 31 allowing allow VBG cord-257899-l866puqk 27 32 B b NN cord-257899-l866puqk 27 33 cells cell NNS cord-257899-l866puqk 27 34 to to TO cord-257899-l866puqk 27 35 face face VB cord-257899-l866puqk 27 36 the the DT cord-257899-l866puqk 27 37 natural natural JJ cord-257899-l866puqk 27 38 conformation conformation NN cord-257899-l866puqk 27 39 of of IN cord-257899-l866puqk 27 40 the the DT cord-257899-l866puqk 27 41 virus virus NN cord-257899-l866puqk 27 42 . . . cord-257899-l866puqk 28 1 The the DT cord-257899-l866puqk 28 2 authors author NNS cord-257899-l866puqk 28 3 concentrated concentrate VBD cord-257899-l866puqk 28 4 on on IN cord-257899-l866puqk 28 5 the the DT cord-257899-l866puqk 28 6 use use NN cord-257899-l866puqk 28 7 of of IN cord-257899-l866puqk 28 8 flagellin flagellin NNP cord-257899-l866puqk 28 9 , , , cord-257899-l866puqk 28 10 a a DT cord-257899-l866puqk 28 11 potent potent JJ cord-257899-l866puqk 28 12 inducer inducer NN cord-257899-l866puqk 28 13 of of IN cord-257899-l866puqk 28 14 innate innate JJ cord-257899-l866puqk 28 15 immunity immunity NN cord-257899-l866puqk 28 16 via via IN cord-257899-l866puqk 28 17 toll toll NN cord-257899-l866puqk 28 18 - - HYPH cord-257899-l866puqk 28 19 like like JJ cord-257899-l866puqk 28 20 receptor receptor NN cord-257899-l866puqk 28 21 5 5 CD cord-257899-l866puqk 28 22 , , , cord-257899-l866puqk 28 23 as as IN cord-257899-l866puqk 28 24 an an DT cord-257899-l866puqk 28 25 adjuvant adjuvant NN cord-257899-l866puqk 28 26 to to TO cord-257899-l866puqk 28 27 formulate formulate VB cord-257899-l866puqk 28 28 human human JJ cord-257899-l866puqk 28 29 immunodeficiency immunodeficiency NN cord-257899-l866puqk 28 30 virus virus NN cord-257899-l866puqk 28 31 ( ( -LRB- cord-257899-l866puqk 28 32 HIV)-based hiv)-based JJ cord-257899-l866puqk 28 33 nanoparticle nanoparticle NN cord-257899-l866puqk 28 34 B b NN cord-257899-l866puqk 28 35 cell cell NN cord-257899-l866puqk 28 36 - - HYPH cord-257899-l866puqk 28 37 targeting target VBG cord-257899-l866puqk 28 38 vaccines vaccine NNS cord-257899-l866puqk 28 39 that that WDT cord-257899-l866puqk 28 40 display display VBP cord-257899-l866puqk 28 41 either either CC cord-257899-l866puqk 28 42 the the DT cord-257899-l866puqk 28 43 HIV-1 HIV-1 NNP cord-257899-l866puqk 28 44 envelope envelope NN cord-257899-l866puqk 28 45 protein protein NN cord-257899-l866puqk 28 46 ( ( -LRB- cord-257899-l866puqk 28 47 Env Env NNP cord-257899-l866puqk 28 48 ) ) -RRB- cord-257899-l866puqk 28 49 or or CC cord-257899-l866puqk 28 50 a a DT cord-257899-l866puqk 28 51 model model NN cord-257899-l866puqk 28 52 antigen antigen NN cord-257899-l866puqk 28 53 , , , cord-257899-l866puqk 28 54 hen hen NN cord-257899-l866puqk 28 55 egg egg NN cord-257899-l866puqk 28 56 lysozyme lysozyme NNS cord-257899-l866puqk 28 57 ( ( -LRB- cord-257899-l866puqk 28 58 HEL HEL NNP cord-257899-l866puqk 28 59 ) ) -RRB- cord-257899-l866puqk 28 60 . . . cord-257899-l866puqk 29 1 They -PRON- PRP cord-257899-l866puqk 29 2 postulated postulate VBD cord-257899-l866puqk 29 3 that that IN cord-257899-l866puqk 29 4 , , , cord-257899-l866puqk 29 5 in in IN cord-257899-l866puqk 29 6 the the DT cord-257899-l866puqk 29 7 context context NN cord-257899-l866puqk 29 8 of of IN cord-257899-l866puqk 29 9 VLP VLP NNP cord-257899-l866puqk 29 10 - - HYPH cord-257899-l866puqk 29 11 based base VBN cord-257899-l866puqk 29 12 B B NNP cord-257899-l866puqk 29 13 cell cell NN cord-257899-l866puqk 29 14 nano nano NN cord-257899-l866puqk 29 15 - - HYPH cord-257899-l866puqk 29 16 vaccines vaccine NNS cord-257899-l866puqk 29 17 , , , cord-257899-l866puqk 29 18 flagellin flagellin NNP cord-257899-l866puqk 29 19 may may MD cord-257899-l866puqk 29 20 outcompete outcompete VB cord-257899-l866puqk 29 21 against against IN cord-257899-l866puqk 29 22 a a DT cord-257899-l866puqk 29 23 less less RBR cord-257899-l866puqk 29 24 immunogenic immunogenic JJ cord-257899-l866puqk 29 25 antigen antigen NN cord-257899-l866puqk 29 26 , , , cord-257899-l866puqk 29 27 while while IN cord-257899-l866puqk 29 28 , , , cord-257899-l866puqk 29 29 in in IN cord-257899-l866puqk 29 30 combination combination NN cord-257899-l866puqk 29 31 with with IN cord-257899-l866puqk 29 32 a a DT cord-257899-l866puqk 29 33 strong strong JJ cord-257899-l866puqk 29 34 immunogen immunogen NN cord-257899-l866puqk 29 35 , , , cord-257899-l866puqk 29 36 the the DT cord-257899-l866puqk 29 37 adjuvanticity adjuvanticity NN cord-257899-l866puqk 29 38 of of IN cord-257899-l866puqk 29 39 flagellin flagellin NNP cord-257899-l866puqk 29 40 dominates dominate VBZ cord-257899-l866puqk 29 41 over over IN cord-257899-l866puqk 29 42 its -PRON- PRP$ cord-257899-l866puqk 29 43 immunogenicity immunogenicity NN cord-257899-l866puqk 29 44 . . . cord-257899-l866puqk 30 1 Kang Kang NNP cord-257899-l866puqk 30 2 et et NNP cord-257899-l866puqk 30 3 al al NNP cord-257899-l866puqk 30 4 . . . cord-257899-l866puqk 31 1 [ [ -LRB- cord-257899-l866puqk 31 2 5 5 CD cord-257899-l866puqk 31 3 ] ] -RRB- cord-257899-l866puqk 31 4 introduced introduce VBD cord-257899-l866puqk 31 5 a a DT cord-257899-l866puqk 31 6 VLP VLP NNP cord-257899-l866puqk 31 7 vaccine vaccine NN cord-257899-l866puqk 31 8 containing contain VBG cord-257899-l866puqk 31 9 Rhoptry Rhoptry NNP cord-257899-l866puqk 31 10 organelle organelle NN cord-257899-l866puqk 31 11 proteins protein NNS cord-257899-l866puqk 31 12 ( ( -LRB- cord-257899-l866puqk 31 13 ROP)4 ROP)4 NNP cord-257899-l866puqk 32 1 and/or and/or CC cord-257899-l866puqk 33 1 ROP13 ROP13 NNP cord-257899-l866puqk 33 2 secreted secrete VBN cord-257899-l866puqk 33 3 by by IN cord-257899-l866puqk 33 4 Toxoplasma Toxoplasma NNP cord-257899-l866puqk 33 5 gondii gondii NNP cord-257899-l866puqk 33 6 together together RB cord-257899-l866puqk 33 7 with with IN cord-257899-l866puqk 33 8 influenza influenza NN cord-257899-l866puqk 33 9 M1 M1 NNP cord-257899-l866puqk 33 10 . . . cord-257899-l866puqk 34 1 It -PRON- PRP cord-257899-l866puqk 34 2 was be VBD cord-257899-l866puqk 34 3 intriguing intriguing JJ cord-257899-l866puqk 34 4 that that IN cord-257899-l866puqk 34 5 upon upon IN cord-257899-l866puqk 34 6 challenge challenge NN cord-257899-l866puqk 34 7 via via IN cord-257899-l866puqk 34 8 the the DT cord-257899-l866puqk 34 9 oral oral JJ cord-257899-l866puqk 34 10 route route NN cord-257899-l866puqk 34 11 , , , cord-257899-l866puqk 34 12 mice mouse NNS cord-257899-l866puqk 34 13 immunized immunize VBN cord-257899-l866puqk 34 14 with with IN cord-257899-l866puqk 34 15 ROP(4 ROP(4 NNP cord-257899-l866puqk 35 1 + + SYM cord-257899-l866puqk 35 2 13 13 CD cord-257899-l866puqk 35 3 ) ) -RRB- cord-257899-l866puqk 35 4 VLPs vlp NNS cord-257899-l866puqk 35 5 elicited elicit VBD cord-257899-l866puqk 35 6 higher high JJR cord-257899-l866puqk 35 7 levels level NNS cord-257899-l866puqk 35 8 of of IN cord-257899-l866puqk 35 9 T. t. NN cord-257899-l866puqk 35 10 gondii gondii NN cord-257899-l866puqk 35 11 - - HYPH cord-257899-l866puqk 35 12 specific specific JJ cord-257899-l866puqk 35 13 IgG igg NN cord-257899-l866puqk 35 14 and and CC cord-257899-l866puqk 35 15 IgA IgA NNP cord-257899-l866puqk 35 16 responses response NNS cord-257899-l866puqk 35 17 in in IN cord-257899-l866puqk 35 18 fecal fecal JJ cord-257899-l866puqk 35 19 , , , cord-257899-l866puqk 35 20 urine urine NN cord-257899-l866puqk 35 21 , , , cord-257899-l866puqk 35 22 intestine intestine NN cord-257899-l866puqk 35 23 and and CC cord-257899-l866puqk 35 24 vaginal vaginal JJ cord-257899-l866puqk 35 25 samples sample NNS cord-257899-l866puqk 35 26 in in IN cord-257899-l866puqk 35 27 accordance accordance NN cord-257899-l866puqk 35 28 with with IN cord-257899-l866puqk 35 29 CD4 CD4 NNP cord-257899-l866puqk 35 30 + + CC cord-257899-l866puqk 35 31 T T NNP cord-257899-l866puqk 35 32 , , , cord-257899-l866puqk 35 33 CD8 CD8 NNP cord-257899-l866puqk 35 34 + + CC cord-257899-l866puqk 35 35 T T NNP cord-257899-l866puqk 35 36 cells cell NNS cord-257899-l866puqk 35 37 , , , cord-257899-l866puqk 35 38 and and CC cord-257899-l866puqk 35 39 germinal germinal JJ cord-257899-l866puqk 35 40 center center NN cord-257899-l866puqk 35 41 B B NNP cord-257899-l866puqk 35 42 cell cell NN cord-257899-l866puqk 35 43 responses response NNS cord-257899-l866puqk 35 44 when when WRB cord-257899-l866puqk 35 45 compared compare VBN cord-257899-l866puqk 35 46 with with IN cord-257899-l866puqk 35 47 other other JJ cord-257899-l866puqk 35 48 vaccines vaccine NNS cord-257899-l866puqk 35 49 , , , cord-257899-l866puqk 35 50 ROP4 ROP4 NNP cord-257899-l866puqk 35 51 VLPs vlp NNS cord-257899-l866puqk 35 52 , , , cord-257899-l866puqk 35 53 ROP13 ROP13 NNP cord-257899-l866puqk 35 54 VLPs VLPs NNP cord-257899-l866puqk 35 55 , , , cord-257899-l866puqk 35 56 and and CC cord-257899-l866puqk 35 57 ROP4+ROP13 ROP4+ROP13 NNP cord-257899-l866puqk 35 58 VLPs vlp NNS cord-257899-l866puqk 35 59 . . . cord-257899-l866puqk 36 1 Thus thus RB cord-257899-l866puqk 36 2 , , , cord-257899-l866puqk 36 3 the the DT cord-257899-l866puqk 36 4 article article NN cord-257899-l866puqk 36 5 shed shed VBD cord-257899-l866puqk 36 6 light light NN cord-257899-l866puqk 36 7 on on IN cord-257899-l866puqk 36 8 important important JJ cord-257899-l866puqk 36 9 insights insight NNS cord-257899-l866puqk 36 10 and and CC cord-257899-l866puqk 36 11 potential potential JJ cord-257899-l866puqk 36 12 strategies strategy NNS cord-257899-l866puqk 36 13 for for IN cord-257899-l866puqk 36 14 the the DT cord-257899-l866puqk 36 15 design design NN cord-257899-l866puqk 36 16 of of IN cord-257899-l866puqk 36 17 a a DT cord-257899-l866puqk 36 18 vaccine vaccine NN cord-257899-l866puqk 36 19 using use VBG cord-257899-l866puqk 36 20 the the DT cord-257899-l866puqk 36 21 T. T. NNP cord-257899-l866puqk 36 22 gondii gondii NNP cord-257899-l866puqk 36 23 ROPs rop NNS cord-257899-l866puqk 36 24 and and CC cord-257899-l866puqk 36 25 VLP VLP NNP cord-257899-l866puqk 36 26 system system NN cord-257899-l866puqk 36 27 . . . cord-257899-l866puqk 37 1 Viyayan Viyayan NNP cord-257899-l866puqk 37 2 et et NNP cord-257899-l866puqk 37 3 al al NNP cord-257899-l866puqk 37 4 . . . cord-257899-l866puqk 38 1 [ [ -LRB- cord-257899-l866puqk 38 2 6 6 CD cord-257899-l866puqk 38 3 ] ] -RRB- cord-257899-l866puqk 38 4 discussed discuss VBN cord-257899-l866puqk 38 5 biomimetic biomimetic JJ cord-257899-l866puqk 38 6 nanoparticles nanoparticle NNS cord-257899-l866puqk 38 7 ( ( -LRB- cord-257899-l866puqk 38 8 NPs NPs NNP cord-257899-l866puqk 38 9 ) ) -RRB- cord-257899-l866puqk 38 10 to to TO cord-257899-l866puqk 38 11 deliver deliver VB cord-257899-l866puqk 38 12 vaccines vaccine NNS cord-257899-l866puqk 38 13 for for IN cord-257899-l866puqk 38 14 the the DT cord-257899-l866puqk 38 15 treatment treatment NN cord-257899-l866puqk 38 16 of of IN cord-257899-l866puqk 38 17 diseases disease NNS cord-257899-l866puqk 38 18 including include VBG cord-257899-l866puqk 38 19 HIV HIV NNP cord-257899-l866puqk 38 20 , , , cord-257899-l866puqk 38 21 malaria malaria NN cord-257899-l866puqk 38 22 , , , cord-257899-l866puqk 38 23 some some DT cord-257899-l866puqk 38 24 tumors tumor NNS cord-257899-l866puqk 38 25 and and CC cord-257899-l866puqk 38 26 bacterial bacterial JJ cord-257899-l866puqk 38 27 diseases disease NNS cord-257899-l866puqk 38 28 due due IN cord-257899-l866puqk 38 29 to to IN cord-257899-l866puqk 38 30 their -PRON- PRP$ cord-257899-l866puqk 38 31 beneficial beneficial JJ cord-257899-l866puqk 38 32 advantages advantage NNS cord-257899-l866puqk 38 33 such such JJ cord-257899-l866puqk 38 34 as as IN cord-257899-l866puqk 38 35 improved improve VBN cord-257899-l866puqk 38 36 antigen antigen NN cord-257899-l866puqk 38 37 stability stability NN cord-257899-l866puqk 38 38 , , , cord-257899-l866puqk 38 39 targeted target VBN cord-257899-l866puqk 38 40 delivery delivery NN cord-257899-l866puqk 38 41 , , , cord-257899-l866puqk 38 42 long long JJ cord-257899-l866puqk 38 43 - - HYPH cord-257899-l866puqk 38 44 time time NN cord-257899-l866puqk 38 45 controlled control VBN cord-257899-l866puqk 38 46 release release NN cord-257899-l866puqk 38 47 and and CC cord-257899-l866puqk 38 48 evasion evasion NN cord-257899-l866puqk 38 49 of of IN cord-257899-l866puqk 38 50 immune immune JJ cord-257899-l866puqk 38 51 responses response NNS cord-257899-l866puqk 38 52 . . . cord-257899-l866puqk 39 1 They -PRON- PRP cord-257899-l866puqk 39 2 covered cover VBD cord-257899-l866puqk 39 3 four four CD cord-257899-l866puqk 39 4 kinds kind NNS cord-257899-l866puqk 39 5 of of IN cord-257899-l866puqk 39 6 biomimetic biomimetic JJ cord-257899-l866puqk 39 7 NPs NPs NNPS cord-257899-l866puqk 39 8 for for IN cord-257899-l866puqk 39 9 the the DT cord-257899-l866puqk 39 10 delivery delivery NN cord-257899-l866puqk 39 11 of of IN cord-257899-l866puqk 39 12 vaccines vaccine NNS cord-257899-l866puqk 39 13 . . . cord-257899-l866puqk 40 1 The the DT cord-257899-l866puqk 40 2 first first JJ cord-257899-l866puqk 40 3 was be VBD cord-257899-l866puqk 40 4 liposomes liposome NNS cord-257899-l866puqk 40 5 , , , cord-257899-l866puqk 40 6 obtained obtain VBN cord-257899-l866puqk 40 7 by by IN cord-257899-l866puqk 40 8 the the DT cord-257899-l866puqk 40 9 dispersion dispersion NN cord-257899-l866puqk 40 10 of of IN cord-257899-l866puqk 40 11 phospholipids phospholipid NNS cord-257899-l866puqk 40 12 in in IN cord-257899-l866puqk 40 13 water water NN cord-257899-l866puqk 40 14 , , , cord-257899-l866puqk 40 15 because because IN cord-257899-l866puqk 40 16 they -PRON- PRP cord-257899-l866puqk 40 17 display display VBP cord-257899-l866puqk 40 18 high high JJ cord-257899-l866puqk 40 19 antigen antigen NN cord-257899-l866puqk 40 20 loading loading NN cord-257899-l866puqk 40 21 and and CC cord-257899-l866puqk 40 22 co co NN cord-257899-l866puqk 40 23 - - NN cord-257899-l866puqk 40 24 delivery delivery NN cord-257899-l866puqk 40 25 of of IN cord-257899-l866puqk 40 26 both both CC cord-257899-l866puqk 40 27 hydrophobic hydrophobic JJ cord-257899-l866puqk 40 28 and and CC cord-257899-l866puqk 40 29 hydrophilic hydrophilic JJ cord-257899-l866puqk 40 30 antigens antigen NNS cord-257899-l866puqk 40 31 . . . cord-257899-l866puqk 41 1 The the DT cord-257899-l866puqk 41 2 second second JJ cord-257899-l866puqk 41 3 was be VBD cord-257899-l866puqk 41 4 NPs NPs NNP cord-257899-l866puqk 41 5 coated coat VBN cord-257899-l866puqk 41 6 with with IN cord-257899-l866puqk 41 7 cell cell NN cord-257899-l866puqk 41 8 membranes membrane NNS cord-257899-l866puqk 41 9 from from IN cord-257899-l866puqk 41 10 red red JJ cord-257899-l866puqk 41 11 blood blood NN cord-257899-l866puqk 41 12 cells cell NNS cord-257899-l866puqk 41 13 , , , cord-257899-l866puqk 41 14 leukocytes leukocyte NNS cord-257899-l866puqk 41 15 , , , cord-257899-l866puqk 41 16 cytotoxic cytotoxic JJ cord-257899-l866puqk 41 17 T t NN cord-257899-l866puqk 41 18 - - HYPH cord-257899-l866puqk 41 19 cells cell NNS cord-257899-l866puqk 41 20 , , , cord-257899-l866puqk 41 21 NK NK NNP cord-257899-l866puqk 41 22 cells cell NNS cord-257899-l866puqk 41 23 , , , cord-257899-l866puqk 41 24 platelets platelet NNS cord-257899-l866puqk 41 25 , , , cord-257899-l866puqk 41 26 macrophages macrophage NNS cord-257899-l866puqk 41 27 or or CC cord-257899-l866puqk 41 28 cancer cancer NN cord-257899-l866puqk 41 29 cells cell NNS cord-257899-l866puqk 41 30 , , , cord-257899-l866puqk 41 31 because because IN cord-257899-l866puqk 41 32 they -PRON- PRP cord-257899-l866puqk 41 33 preserve preserve VBP cord-257899-l866puqk 41 34 the the DT cord-257899-l866puqk 41 35 physicochemical physicochemical JJ cord-257899-l866puqk 41 36 properties property NNS cord-257899-l866puqk 41 37 of of IN cord-257899-l866puqk 41 38 the the DT cord-257899-l866puqk 41 39 core core NN cord-257899-l866puqk 41 40 synthetic synthetic NN cord-257899-l866puqk 41 41 NPs NPs NNPS cord-257899-l866puqk 41 42 and and CC cord-257899-l866puqk 41 43 maintain maintain VB cord-257899-l866puqk 41 44 the the DT cord-257899-l866puqk 41 45 cellular cellular JJ cord-257899-l866puqk 41 46 composition composition NN cord-257899-l866puqk 41 47 on on IN cord-257899-l866puqk 41 48 their -PRON- PRP$ cord-257899-l866puqk 41 49 membrane membrane NN cord-257899-l866puqk 41 50 shell shell NN cord-257899-l866puqk 41 51 . . . cord-257899-l866puqk 42 1 The the DT cord-257899-l866puqk 42 2 third third JJ cord-257899-l866puqk 42 3 was be VBD cord-257899-l866puqk 42 4 self self NN cord-257899-l866puqk 42 5 - - HYPH cord-257899-l866puqk 42 6 assembled assemble VBN cord-257899-l866puqk 42 7 proteins protein NNS cord-257899-l866puqk 42 8 , , , cord-257899-l866puqk 42 9 because because IN cord-257899-l866puqk 42 10 they -PRON- PRP cord-257899-l866puqk 42 11 play play VBP cord-257899-l866puqk 42 12 diverse diverse JJ cord-257899-l866puqk 42 13 physiological physiological JJ cord-257899-l866puqk 42 14 roles role NNS cord-257899-l866puqk 42 15 and and CC cord-257899-l866puqk 42 16 mimic mimic VB cord-257899-l866puqk 42 17 natural natural JJ cord-257899-l866puqk 42 18 microbe microbe NN cord-257899-l866puqk 42 19 architectures architecture NNS cord-257899-l866puqk 42 20 . . . cord-257899-l866puqk 43 1 The the DT cord-257899-l866puqk 43 2 fourth fourth JJ cord-257899-l866puqk 43 3 was be VBD cord-257899-l866puqk 43 4 virus virus NN cord-257899-l866puqk 43 5 - - HYPH cord-257899-l866puqk 43 6 like like JJ cord-257899-l866puqk 43 7 NPs NPs NNPS cord-257899-l866puqk 43 8 containing contain VBG cord-257899-l866puqk 43 9 noninfectious noninfectious JJ cord-257899-l866puqk 43 10 subsets subset NNS cord-257899-l866puqk 43 11 of of IN cord-257899-l866puqk 43 12 viruses virus NNS cord-257899-l866puqk 43 13 , , , cord-257899-l866puqk 43 14 because because IN cord-257899-l866puqk 43 15 they -PRON- PRP cord-257899-l866puqk 43 16 assemble assemble VBP cord-257899-l866puqk 43 17 without without IN cord-257899-l866puqk 43 18 containing contain VBG cord-257899-l866puqk 43 19 any any DT cord-257899-l866puqk 43 20 viral viral JJ cord-257899-l866puqk 43 21 RNA rna NN cord-257899-l866puqk 43 22 . . . cord-257899-l866puqk 44 1 Sartorius Sartorius NNP cord-257899-l866puqk 44 2 et et NNP cord-257899-l866puqk 44 3 al al NNP cord-257899-l866puqk 44 4 . . . cord-257899-l866puqk 45 1 [ [ -LRB- cord-257899-l866puqk 45 2 7 7 CD cord-257899-l866puqk 45 3 ] ] -RRB- cord-257899-l866puqk 45 4 described describe VBD cord-257899-l866puqk 45 5 the the DT cord-257899-l866puqk 45 6 possibility possibility NN cord-257899-l866puqk 45 7 of of IN cord-257899-l866puqk 45 8 filamentous filamentous JJ cord-257899-l866puqk 45 9 bacteriophages bacteriophage NNS cord-257899-l866puqk 45 10 ( ( -LRB- cord-257899-l866puqk 45 11 FBs FBs NNPS cord-257899-l866puqk 45 12 ) ) -RRB- cord-257899-l866puqk 45 13 , , , cord-257899-l866puqk 45 14 prepared prepare VBN cord-257899-l866puqk 45 15 by by IN cord-257899-l866puqk 45 16 phage phage NN cord-257899-l866puqk 45 17 display display NN cord-257899-l866puqk 45 18 technology technology NN cord-257899-l866puqk 45 19 , , , cord-257899-l866puqk 45 20 as as IN cord-257899-l866puqk 45 21 nature nature NN cord-257899-l866puqk 45 22 - - HYPH cord-257899-l866puqk 45 23 made make VBN cord-257899-l866puqk 45 24 NPs NPs NNPS cord-257899-l866puqk 45 25 to to TO cord-257899-l866puqk 45 26 deliver deliver VB cord-257899-l866puqk 45 27 therapeutic therapeutic JJ cord-257899-l866puqk 45 28 vaccines vaccine NNS cord-257899-l866puqk 45 29 , , , cord-257899-l866puqk 45 30 because because IN cord-257899-l866puqk 45 31 lytic lytic JJ cord-257899-l866puqk 45 32 bacteriophages bacteriophage NNS cord-257899-l866puqk 45 33 have have VBP cord-257899-l866puqk 45 34 been be VBN cord-257899-l866puqk 45 35 used use VBN cord-257899-l866puqk 45 36 as as IN cord-257899-l866puqk 45 37 antibacterial antibacterial JJ cord-257899-l866puqk 45 38 materials material NNS cord-257899-l866puqk 45 39 in in IN cord-257899-l866puqk 45 40 several several JJ cord-257899-l866puqk 45 41 clinical clinical JJ cord-257899-l866puqk 45 42 trials trial NNS cord-257899-l866puqk 45 43 due due IN cord-257899-l866puqk 45 44 to to IN cord-257899-l866puqk 45 45 their -PRON- PRP$ cord-257899-l866puqk 45 46 safe safe JJ cord-257899-l866puqk 45 47 and and CC cord-257899-l866puqk 45 48 inexpensive inexpensive JJ cord-257899-l866puqk 45 49 therapeutic therapeutic JJ cord-257899-l866puqk 45 50 behavior behavior NN cord-257899-l866puqk 45 51 , , , cord-257899-l866puqk 45 52 where where WRB cord-257899-l866puqk 45 53 the the DT cord-257899-l866puqk 45 54 FBs fb NNS cord-257899-l866puqk 45 55 enter enter VBP cord-257899-l866puqk 45 56 the the DT cord-257899-l866puqk 45 57 blood blood NN cord-257899-l866puqk 45 58 vessels vessel NNS cord-257899-l866puqk 45 59 easily easily RB cord-257899-l866puqk 45 60 , , , cord-257899-l866puqk 45 61 owing owe VBG cord-257899-l866puqk 45 62 to to IN cord-257899-l866puqk 45 63 their -PRON- PRP$ cord-257899-l866puqk 45 64 nano nano NN cord-257899-l866puqk 45 65 size size NN cord-257899-l866puqk 45 66 , , , cord-257899-l866puqk 45 67 and and CC cord-257899-l866puqk 45 68 exhibit exhibit VB cord-257899-l866puqk 45 69 high high JJ cord-257899-l866puqk 45 70 - - HYPH cord-257899-l866puqk 45 71 density density NN cord-257899-l866puqk 45 72 antigen antigen NN cord-257899-l866puqk 45 73 expression expression NN cord-257899-l866puqk 45 74 . . . cord-257899-l866puqk 46 1 The the DT cord-257899-l866puqk 46 2 authors author NNS cord-257899-l866puqk 46 3 showed show VBD cord-257899-l866puqk 46 4 the the DT cord-257899-l866puqk 46 5 induction induction NN cord-257899-l866puqk 46 6 of of IN cord-257899-l866puqk 46 7 specific specific JJ cord-257899-l866puqk 46 8 cytotoxic cytotoxic JJ cord-257899-l866puqk 46 9 T t NN cord-257899-l866puqk 46 10 cell cell NN cord-257899-l866puqk 46 11 responses response NNS cord-257899-l866puqk 46 12 to to IN cord-257899-l866puqk 46 13 HLA HLA NNP cord-257899-l866puqk 46 14 - - HYPH cord-257899-l866puqk 46 15 A2-restricted A2-restricted NNP cord-257899-l866puqk 46 16 and and CC cord-257899-l866puqk 46 17 hepatitis hepatitis NNP cord-257899-l866puqk 46 18 B B NNP cord-257899-l866puqk 46 19 virus virus NN cord-257899-l866puqk 46 20 epitopes epitope NNS cord-257899-l866puqk 46 21 due due JJ cord-257899-l866puqk 46 22 to to IN cord-257899-l866puqk 46 23 the the DT cord-257899-l866puqk 46 24 ability ability NN cord-257899-l866puqk 46 25 of of IN cord-257899-l866puqk 46 26 the the DT cord-257899-l866puqk 46 27 filamentous filamentous JJ cord-257899-l866puqk 46 28 rod rod NN cord-257899-l866puqk 46 29 , , , cord-257899-l866puqk 46 30 internalized internalize VBN cord-257899-l866puqk 46 31 into into IN cord-257899-l866puqk 46 32 APCs apc NNS cord-257899-l866puqk 46 33 . . . cord-257899-l866puqk 47 1 It -PRON- PRP cord-257899-l866puqk 47 2 seems seem VBZ cord-257899-l866puqk 47 3 likely likely JJ cord-257899-l866puqk 47 4 that that IN cord-257899-l866puqk 47 5 the the DT cord-257899-l866puqk 47 6 targeted target VBN cord-257899-l866puqk 47 7 delivery delivery NN cord-257899-l866puqk 47 8 of of IN cord-257899-l866puqk 47 9 these these DT cord-257899-l866puqk 47 10 NPs NPs NNPS cord-257899-l866puqk 47 11 in in IN cord-257899-l866puqk 47 12 new new JJ cord-257899-l866puqk 47 13 - - HYPH cord-257899-l866puqk 47 14 generation generation NN cord-257899-l866puqk 47 15 vaccines vaccine NNS cord-257899-l866puqk 47 16 against against IN cord-257899-l866puqk 47 17 tumors tumor NNS cord-257899-l866puqk 47 18 such such JJ cord-257899-l866puqk 47 19 as as IN cord-257899-l866puqk 47 20 melanoma melanoma NN cord-257899-l866puqk 47 21 and and CC cord-257899-l866puqk 47 22 mastocytoma mastocytoma NNP cord-257899-l866puqk 47 23 might may MD cord-257899-l866puqk 47 24 be be VB cord-257899-l866puqk 47 25 realized realize VBN cord-257899-l866puqk 47 26 , , , cord-257899-l866puqk 47 27 although although IN cord-257899-l866puqk 47 28 clinical clinical JJ cord-257899-l866puqk 47 29 trials trial NNS cord-257899-l866puqk 47 30 are be VBP cord-257899-l866puqk 47 31 necessary necessary JJ cord-257899-l866puqk 47 32 to to TO cord-257899-l866puqk 47 33 establish establish VB cord-257899-l866puqk 47 34 their -PRON- PRP$ cord-257899-l866puqk 47 35 safety safety NN cord-257899-l866puqk 47 36 in in IN cord-257899-l866puqk 47 37 humans human NNS cord-257899-l866puqk 47 38 . . . cord-257899-l866puqk 48 1 Lim Lim NNP cord-257899-l866puqk 48 2 et et NNP cord-257899-l866puqk 48 3 al al NNP cord-257899-l866puqk 48 4 . . . cord-257899-l866puqk 49 1 [ [ -LRB- cord-257899-l866puqk 49 2 8 8 CD cord-257899-l866puqk 49 3 ] ] -RRB- cord-257899-l866puqk 49 4 described describe VBD cord-257899-l866puqk 49 5 nano nano NN cord-257899-l866puqk 49 6 delivery delivery NN cord-257899-l866puqk 49 7 systems system NNS cord-257899-l866puqk 49 8 for for IN cord-257899-l866puqk 49 9 the the DT cord-257899-l866puqk 49 10 improvement improvement NN cord-257899-l866puqk 49 11 of of IN cord-257899-l866puqk 49 12 the the DT cord-257899-l866puqk 49 13 enhanced enhance VBN cord-257899-l866puqk 49 14 gene gene NN cord-257899-l866puqk 49 15 expression expression NN cord-257899-l866puqk 49 16 of of IN cord-257899-l866puqk 49 17 DNA dna NN cord-257899-l866puqk 49 18 vaccines vaccine NNS cord-257899-l866puqk 49 19 that that WDT cord-257899-l866puqk 49 20 provide provide VBP cord-257899-l866puqk 49 21 potent potent JJ cord-257899-l866puqk 49 22 humoral humoral JJ cord-257899-l866puqk 49 23 and and CC cord-257899-l866puqk 49 24 cell cell NN cord-257899-l866puqk 49 25 - - HYPH cord-257899-l866puqk 49 26 mediated mediate VBN cord-257899-l866puqk 49 27 responses response NNS cord-257899-l866puqk 49 28 . . . cord-257899-l866puqk 50 1 They -PRON- PRP cord-257899-l866puqk 50 2 pointed point VBD cord-257899-l866puqk 50 3 out out RP cord-257899-l866puqk 50 4 the the DT cord-257899-l866puqk 50 5 limitations limitation NNS cord-257899-l866puqk 50 6 of of IN cord-257899-l866puqk 50 7 their -PRON- PRP$ cord-257899-l866puqk 50 8 clinical clinical JJ cord-257899-l866puqk 50 9 applications application NNS cord-257899-l866puqk 50 10 , , , cord-257899-l866puqk 50 11 which which WDT cord-257899-l866puqk 50 12 present present VBP cord-257899-l866puqk 50 13 hurdles hurdle NNS cord-257899-l866puqk 50 14 in in IN cord-257899-l866puqk 50 15 their -PRON- PRP$ cord-257899-l866puqk 50 16 delivery delivery NN cord-257899-l866puqk 50 17 to to IN cord-257899-l866puqk 50 18 targeted target VBN cord-257899-l866puqk 50 19 immune immune JJ cord-257899-l866puqk 50 20 cells cell NNS cord-257899-l866puqk 50 21 , , , cord-257899-l866puqk 50 22 although although IN cord-257899-l866puqk 50 23 none none NN cord-257899-l866puqk 50 24 have have VBP cord-257899-l866puqk 50 25 been be VBN cord-257899-l866puqk 50 26 approved approve VBN cord-257899-l866puqk 50 27 for for IN cord-257899-l866puqk 50 28 clinical clinical JJ cord-257899-l866puqk 50 29 use use NN cord-257899-l866puqk 50 30 thus thus RB cord-257899-l866puqk 50 31 far far RB cord-257899-l866puqk 50 32 . . . cord-257899-l866puqk 51 1 The the DT cord-257899-l866puqk 51 2 authors author NNS cord-257899-l866puqk 51 3 discussed discuss VBD cord-257899-l866puqk 51 4 the the DT cord-257899-l866puqk 51 5 advantages advantage NNS cord-257899-l866puqk 51 6 and and CC cord-257899-l866puqk 51 7 weaknesses weakness NNS cord-257899-l866puqk 51 8 of of IN cord-257899-l866puqk 51 9 polymeric polymeric JJ cord-257899-l866puqk 51 10 NPs NPs NNP cord-257899-l866puqk 51 11 , , , cord-257899-l866puqk 51 12 lipid lipid NN cord-257899-l866puqk 51 13 NPs NPs NNP cord-257899-l866puqk 51 14 , , , cord-257899-l866puqk 51 15 hybrid hybrid JJ cord-257899-l866puqk 51 16 lipid lipid NN cord-257899-l866puqk 51 17 - - HYPH cord-257899-l866puqk 51 18 polymer polymer NN cord-257899-l866puqk 51 19 NPs NPs NNP cord-257899-l866puqk 51 20 , , , cord-257899-l866puqk 51 21 inorganic inorganic JJ cord-257899-l866puqk 51 22 NPs NPs NNP cord-257899-l866puqk 51 23 , , , cord-257899-l866puqk 51 24 virus virus NN cord-257899-l866puqk 51 25 - - HYPH cord-257899-l866puqk 51 26 like like JJ cord-257899-l866puqk 51 27 NPs NPs NNPS cord-257899-l866puqk 51 28 and and CC cord-257899-l866puqk 51 29 protein protein NN cord-257899-l866puqk 51 30 - - HYPH cord-257899-l866puqk 51 31 based base VBN cord-257899-l866puqk 51 32 NPs NPs NNPS cord-257899-l866puqk 51 33 in in IN cord-257899-l866puqk 51 34 the the DT cord-257899-l866puqk 51 35 delivery delivery NN cord-257899-l866puqk 51 36 of of IN cord-257899-l866puqk 51 37 DNA dna NN cord-257899-l866puqk 51 38 vaccines vaccine NNS cord-257899-l866puqk 51 39 . . . cord-257899-l866puqk 52 1 DNA DNA NNP cord-257899-l866puqk 52 2 vaccine vaccine NN cord-257899-l866puqk 52 3 platform platform NN cord-257899-l866puqk 52 4 technology technology NN cord-257899-l866puqk 52 5 would would MD cord-257899-l866puqk 52 6 have have VB cord-257899-l866puqk 52 7 a a DT cord-257899-l866puqk 52 8 high high JJ cord-257899-l866puqk 52 9 chance chance NN cord-257899-l866puqk 52 10 to to TO cord-257899-l866puqk 52 11 be be VB cord-257899-l866puqk 52 12 successful successful JJ cord-257899-l866puqk 52 13 in in IN cord-257899-l866puqk 52 14 clinical clinical JJ cord-257899-l866puqk 52 15 application application NN cord-257899-l866puqk 52 16 if if IN cord-257899-l866puqk 52 17 the the DT cord-257899-l866puqk 52 18 better well JJR cord-257899-l866puqk 52 19 adjuvants adjuvant NNS cord-257899-l866puqk 52 20 and/or and/or CC cord-257899-l866puqk 52 21 the the DT cord-257899-l866puqk 52 22 encoded encoded JJ cord-257899-l866puqk 52 23 antigens antigen NNS cord-257899-l866puqk 52 24 were be VBD cord-257899-l866puqk 52 25 selected select VBN cord-257899-l866puqk 52 26 properly properly RB cord-257899-l866puqk 52 27 . . . cord-257899-l866puqk 53 1 Tan Tan NNP cord-257899-l866puqk 53 2 et et FW cord-257899-l866puqk 53 3 al al NNP cord-257899-l866puqk 53 4 . . . cord-257899-l866puqk 54 1 [ [ -LRB- cord-257899-l866puqk 54 2 9 9 CD cord-257899-l866puqk 54 3 ] ] -RRB- cord-257899-l866puqk 54 4 discussed discuss VBN cord-257899-l866puqk 54 5 norovirus norovirus NN cord-257899-l866puqk 54 6 capsid capsid NN cord-257899-l866puqk 54 7 protein protein NN cord-257899-l866puqk 54 8 - - HYPH cord-257899-l866puqk 54 9 derived derive VBN cord-257899-l866puqk 54 10 NPs NPs NNP cord-257899-l866puqk 54 11 and and CC cord-257899-l866puqk 54 12 polymers polymer NNS cord-257899-l866puqk 54 13 obtained obtain VBN cord-257899-l866puqk 54 14 by by IN cord-257899-l866puqk 54 15 homotypically homotypically NNP cord-257899-l866puqk 54 16 and/or and/or CC cord-257899-l866puqk 54 17 heterotypically heterotypically RB cord-257899-l866puqk 54 18 self self NN cord-257899-l866puqk 54 19 - - HYPH cord-257899-l866puqk 54 20 assembled assemble VBN cord-257899-l866puqk 54 21 mechanisms mechanism NNS cord-257899-l866puqk 54 22 through through IN cord-257899-l866puqk 54 23 bioengineering bioengineere VBG cord-257899-l866puqk 54 24 norovirus norovirus NN cord-257899-l866puqk 54 25 capsid capsid NN cord-257899-l866puqk 54 26 shell shell NN cord-257899-l866puqk 54 27 ( ( -LRB- cord-257899-l866puqk 54 28 S S NNP cord-257899-l866puqk 54 29 ) ) -RRB- cord-257899-l866puqk 54 30 and and CC cord-257899-l866puqk 54 31 protruding protruding JJ cord-257899-l866puqk 54 32 ( ( -LRB- cord-257899-l866puqk 54 33 P p NN cord-257899-l866puqk 54 34 ) ) -RRB- cord-257899-l866puqk 54 35 domains domain NNS cord-257899-l866puqk 54 36 , , , cord-257899-l866puqk 54 37 making make VBG cord-257899-l866puqk 54 38 them -PRON- PRP cord-257899-l866puqk 54 39 efficient efficient JJ cord-257899-l866puqk 54 40 vaccine vaccine NN cord-257899-l866puqk 54 41 candidates candidate NNS cord-257899-l866puqk 54 42 against against IN cord-257899-l866puqk 54 43 noroviruses noroviruse NNS cord-257899-l866puqk 54 44 because because IN cord-257899-l866puqk 54 45 they -PRON- PRP cord-257899-l866puqk 54 46 are be VBP cord-257899-l866puqk 54 47 easily easily RB cord-257899-l866puqk 54 48 produced produce VBN cord-257899-l866puqk 54 49 , , , cord-257899-l866puqk 54 50 highly highly RB cord-257899-l866puqk 54 51 stable stable JJ cord-257899-l866puqk 54 52 , , , cord-257899-l866puqk 54 53 they -PRON- PRP cord-257899-l866puqk 54 54 elicit elicit VBP cord-257899-l866puqk 54 55 strong strong JJ cord-257899-l866puqk 54 56 host host NN cord-257899-l866puqk 54 57 immune immune JJ cord-257899-l866puqk 54 58 responses response NNS cord-257899-l866puqk 54 59 and and CC cord-257899-l866puqk 54 60 several several JJ cord-257899-l866puqk 54 61 chimeric chimeric JJ cord-257899-l866puqk 54 62 S S NNP cord-257899-l866puqk 54 63 60 60 CD cord-257899-l866puqk 54 64 and and CC cord-257899-l866puqk 54 65 P p NN cord-257899-l866puqk 54 66 24 24 CD cord-257899-l866puqk 54 67 NPs NPs NNPS cord-257899-l866puqk 54 68 as as RB cord-257899-l866puqk 54 69 well well RB cord-257899-l866puqk 54 70 as as IN cord-257899-l866puqk 54 71 P p NN cord-257899-l866puqk 54 72 domain domain NN cord-257899-l866puqk 54 73 - - HYPH cord-257899-l866puqk 54 74 derived derive VBN cord-257899-l866puqk 54 75 polymers polymer NNS cord-257899-l866puqk 54 76 , , , cord-257899-l866puqk 54 77 as as IN cord-257899-l866puqk 54 78 shown show VBN cord-257899-l866puqk 54 79 in in IN cord-257899-l866puqk 54 80 other other JJ cord-257899-l866puqk 54 81 virus virus NN cord-257899-l866puqk 54 82 vaccine vaccine NN cord-257899-l866puqk 54 83 candidates candidate NNS cord-257899-l866puqk 54 84 such such JJ cord-257899-l866puqk 54 85 as as IN cord-257899-l866puqk 54 86 rotavirus rotavirus NN cord-257899-l866puqk 54 87 , , , cord-257899-l866puqk 54 88 influenza influenza NN cord-257899-l866puqk 54 89 virus virus NN cord-257899-l866puqk 54 90 , , , cord-257899-l866puqk 54 91 EV EV NNP cord-257899-l866puqk 54 92 71 71 CD cord-257899-l866puqk 54 93 , , , cord-257899-l866puqk 54 94 HIV-1 HIV-1 NNP cord-257899-l866puqk 54 95 , , , cord-257899-l866puqk 54 96 Alzheimer Alzheimer NNP cord-257899-l866puqk 54 97 , , , cord-257899-l866puqk 54 98 and and CC cord-257899-l866puqk 54 99 astrovirus astrovirus JJ cord-257899-l866puqk 54 100 diseases disease NNS cord-257899-l866puqk 54 101 . . . cord-257899-l866puqk 55 1 It -PRON- PRP cord-257899-l866puqk 55 2 may may MD cord-257899-l866puqk 55 3 be be VB cord-257899-l866puqk 55 4 expected expect VBN cord-257899-l866puqk 55 5 that that IN cord-257899-l866puqk 55 6 P p NN cord-257899-l866puqk 55 7 24 24 CD cord-257899-l866puqk 55 8 NPs np NNS cord-257899-l866puqk 55 9 and and CC cord-257899-l866puqk 55 10 polymers polymer NNS cord-257899-l866puqk 55 11 function function VBP cord-257899-l866puqk 55 12 as as IN cord-257899-l866puqk 55 13 multifunctional multifunctional JJ cord-257899-l866puqk 55 14 P p NN cord-257899-l866puqk 55 15 domain domain NN cord-257899-l866puqk 55 16 - - HYPH cord-257899-l866puqk 55 17 based base VBN cord-257899-l866puqk 55 18 oligomer oligomer NNP cord-257899-l866puqk 55 19 vaccine vaccine NN cord-257899-l866puqk 55 20 platforms platform NNS cord-257899-l866puqk 55 21 displaying display VBG cord-257899-l866puqk 55 22 foreign foreign JJ cord-257899-l866puqk 55 23 antigens antigen NNS cord-257899-l866puqk 55 24 . . . cord-257899-l866puqk 56 1 There there EX cord-257899-l866puqk 56 2 are be VBP cord-257899-l866puqk 56 3 two two CD cord-257899-l866puqk 56 4 articles article NNS cord-257899-l866puqk 56 5 describing describe VBG cord-257899-l866puqk 56 6 the the DT cord-257899-l866puqk 56 7 importance importance NN cord-257899-l866puqk 56 8 of of IN cord-257899-l866puqk 56 9 adjuvants adjuvant NNS cord-257899-l866puqk 56 10 . . . cord-257899-l866puqk 57 1 Park Park NNP cord-257899-l866puqk 57 2 et et FW cord-257899-l866puqk 57 3 al al NNP cord-257899-l866puqk 57 4 . . . cord-257899-l866puqk 58 1 [ [ -LRB- cord-257899-l866puqk 58 2 10 10 CD cord-257899-l866puqk 58 3 ] ] -RRB- cord-257899-l866puqk 58 4 described describe VBD cord-257899-l866puqk 58 5 a a DT cord-257899-l866puqk 58 6 novel novel NN cord-257899-l866puqk 58 7 adjuvant adjuvant NN cord-257899-l866puqk 58 8 in in IN cord-257899-l866puqk 58 9 the the DT cord-257899-l866puqk 58 10 form form NN cord-257899-l866puqk 58 11 of of IN cord-257899-l866puqk 58 12 a a DT cord-257899-l866puqk 58 13 single single RB cord-257899-l866puqk 58 14 - - HYPH cord-257899-l866puqk 58 15 stranded strand VBN cord-257899-l866puqk 58 16 RNA RNA NNP cord-257899-l866puqk 58 17 ( ( -LRB- cord-257899-l866puqk 58 18 ssRNA ssRNA VBG cord-257899-l866puqk 58 19 ) ) -RRB- cord-257899-l866puqk 58 20 nano nano NN cord-257899-l866puqk 58 21 - - HYPH cord-257899-l866puqk 58 22 structure structure NN cord-257899-l866puqk 58 23 that that WDT cord-257899-l866puqk 58 24 can can MD cord-257899-l866puqk 58 25 stimulate stimulate VB cord-257899-l866puqk 58 26 both both DT cord-257899-l866puqk 58 27 Th1 th1 NN cord-257899-l866puqk 58 28 and and CC cord-257899-l866puqk 58 29 Th2 th2 CD cord-257899-l866puqk 58 30 responses response NNS cord-257899-l866puqk 58 31 . . . cord-257899-l866puqk 59 1 The the DT cord-257899-l866puqk 59 2 authors author NNS cord-257899-l866puqk 59 3 claimed claim VBD cord-257899-l866puqk 59 4 that that IN cord-257899-l866puqk 59 5 neither neither CC cord-257899-l866puqk 59 6 adverse adverse JJ cord-257899-l866puqk 59 7 side side NN cord-257899-l866puqk 59 8 effects effect NNS cord-257899-l866puqk 59 9 such such JJ cord-257899-l866puqk 59 10 as as IN cord-257899-l866puqk 59 11 hematological hematological JJ cord-257899-l866puqk 59 12 and and CC cord-257899-l866puqk 59 13 serum serum JJ cord-257899-l866puqk 59 14 biochemical biochemical JJ cord-257899-l866puqk 59 15 parameters parameter NNS cord-257899-l866puqk 59 16 , , , cord-257899-l866puqk 59 17 nor nor CC cord-257899-l866puqk 59 18 IgE IgE NNP cord-257899-l866puqk 59 19 and and CC cord-257899-l866puqk 59 20 anti anti JJ cord-257899-l866puqk 59 21 - - JJ cord-257899-l866puqk 59 22 nuclear nuclear JJ cord-257899-l866puqk 59 23 antibodies antibody NNS cord-257899-l866puqk 59 24 , , , cord-257899-l866puqk 59 25 which which WDT cord-257899-l866puqk 59 26 are be VBP cord-257899-l866puqk 59 27 markers marker NNS cord-257899-l866puqk 59 28 of of IN cord-257899-l866puqk 59 29 autoimmune autoimmune JJ cord-257899-l866puqk 59 30 disease disease NN cord-257899-l866puqk 59 31 , , , cord-257899-l866puqk 59 32 was be VBD cord-257899-l866puqk 59 33 found find VBN cord-257899-l866puqk 59 34 , , , cord-257899-l866puqk 59 35 and and CC cord-257899-l866puqk 59 36 postulated postulate VBD cord-257899-l866puqk 59 37 that that IN cord-257899-l866puqk 59 38 this this DT cord-257899-l866puqk 59 39 ssRNA ssRNA `` cord-257899-l866puqk 59 40 nanostructure nanostructure NNP cord-257899-l866puqk 59 41 may may MD cord-257899-l866puqk 59 42 be be VB cord-257899-l866puqk 59 43 an an DT cord-257899-l866puqk 59 44 alternative alternative JJ cord-257899-l866puqk 59 45 choice choice NN cord-257899-l866puqk 59 46 over over IN cord-257899-l866puqk 59 47 traditional traditional JJ cord-257899-l866puqk 59 48 adjuvants adjuvant NNS cord-257899-l866puqk 59 49 . . . cord-257899-l866puqk 60 1 Sharma Sharma NNP cord-257899-l866puqk 60 2 et et NNP cord-257899-l866puqk 60 3 al al NNP cord-257899-l866puqk 60 4 . . . cord-257899-l866puqk 61 1 [ [ -LRB- cord-257899-l866puqk 61 2 11 11 CD cord-257899-l866puqk 61 3 ] ] -RRB- cord-257899-l866puqk 61 4 discussed discuss VBD cord-257899-l866puqk 61 5 the the DT cord-257899-l866puqk 61 6 possibility possibility NN cord-257899-l866puqk 61 7 of of IN cord-257899-l866puqk 61 8 zinc zinc NN cord-257899-l866puqk 61 9 oxide oxide NN cord-257899-l866puqk 61 10 ( ( -LRB- cord-257899-l866puqk 61 11 ZnO)-based ZnO)-based NNP cord-257899-l866puqk 61 12 nanocomposites nanocomposite NNS cord-257899-l866puqk 61 13 as as IN cord-257899-l866puqk 61 14 vaccine vaccine NN cord-257899-l866puqk 61 15 adjuvants adjuvant NNS cord-257899-l866puqk 61 16 and and CC cord-257899-l866puqk 61 17 the the DT cord-257899-l866puqk 61 18 application application NN cord-257899-l866puqk 61 19 of of IN cord-257899-l866puqk 61 20 cancer cancer NN cord-257899-l866puqk 61 21 immunotherapeutics immunotherapeutic NNS cord-257899-l866puqk 61 22 because because IN cord-257899-l866puqk 61 23 of of IN cord-257899-l866puqk 61 24 their -PRON- PRP$ cord-257899-l866puqk 61 25 biocompatibility biocompatibility NN cord-257899-l866puqk 61 26 , , , cord-257899-l866puqk 61 27 unique unique JJ cord-257899-l866puqk 61 28 physicochemical physicochemical JJ cord-257899-l866puqk 61 29 properties property NNS cord-257899-l866puqk 61 30 , , , cord-257899-l866puqk 61 31 cost cost NN cord-257899-l866puqk 61 32 - - HYPH cord-257899-l866puqk 61 33 effective effective JJ cord-257899-l866puqk 61 34 mass mass NN cord-257899-l866puqk 61 35 production production NN cord-257899-l866puqk 61 36 , , , cord-257899-l866puqk 61 37 intrinsic intrinsic JJ cord-257899-l866puqk 61 38 adjuvant adjuvant NN cord-257899-l866puqk 61 39 - - HYPH cord-257899-l866puqk 61 40 like like JJ cord-257899-l866puqk 61 41 properties property NNS cord-257899-l866puqk 61 42 and and CC cord-257899-l866puqk 61 43 immunomodulatory immunomodulatory JJ cord-257899-l866puqk 61 44 function function NN cord-257899-l866puqk 61 45 . . . cord-257899-l866puqk 62 1 The the DT cord-257899-l866puqk 62 2 authors author NNS cord-257899-l866puqk 62 3 introduced introduce VBD cord-257899-l866puqk 62 4 the the DT cord-257899-l866puqk 62 5 effects effect NNS cord-257899-l866puqk 62 6 of of IN cord-257899-l866puqk 62 7 diverse diverse JJ cord-257899-l866puqk 62 8 formulations formulation NNS cord-257899-l866puqk 62 9 and and CC cord-257899-l866puqk 62 10 compositions composition NNS cord-257899-l866puqk 62 11 on on IN cord-257899-l866puqk 62 12 the the DT cord-257899-l866puqk 62 13 efficiency efficiency NN cord-257899-l866puqk 62 14 of of IN cord-257899-l866puqk 62 15 antigen antigen NN cord-257899-l866puqk 62 16 delivery delivery NN cord-257899-l866puqk 62 17 and and CC cord-257899-l866puqk 62 18 immunogenicity immunogenicity NN cord-257899-l866puqk 62 19 by by IN cord-257899-l866puqk 62 20 augmenting augment VBG cord-257899-l866puqk 62 21 antigen antigen NN cord-257899-l866puqk 62 22 processing processing NN cord-257899-l866puqk 62 23 , , , cord-257899-l866puqk 62 24 enhancing enhance VBG cord-257899-l866puqk 62 25 antigen antigen NN cord-257899-l866puqk 62 26 stability stability NN cord-257899-l866puqk 62 27 and and CC cord-257899-l866puqk 62 28 controlling control VBG cord-257899-l866puqk 62 29 the the DT cord-257899-l866puqk 62 30 release release NN cord-257899-l866puqk 62 31 of of IN cord-257899-l866puqk 62 32 antigens antigen NNS cord-257899-l866puqk 62 33 . . . cord-257899-l866puqk 63 1 They -PRON- PRP cord-257899-l866puqk 63 2 described describe VBD cord-257899-l866puqk 63 3 that that IN cord-257899-l866puqk 63 4 the the DT cord-257899-l866puqk 63 5 immunomodulatory immunomodulatory JJ cord-257899-l866puqk 63 6 effects effect NNS cord-257899-l866puqk 63 7 of of IN cord-257899-l866puqk 63 8 these these DT cord-257899-l866puqk 63 9 innate innate JJ cord-257899-l866puqk 63 10 immune immune JJ cord-257899-l866puqk 63 11 cells cell NNS cord-257899-l866puqk 63 12 were be VBD cord-257899-l866puqk 63 13 mediated mediate VBN cord-257899-l866puqk 63 14 by by IN cord-257899-l866puqk 63 15 intracellular intracellular JJ cord-257899-l866puqk 63 16 Zn Zn NNP cord-257899-l866puqk 63 17 2 2 CD cord-257899-l866puqk 63 18 + + CC cord-257899-l866puqk 63 19 dissolution dissolution NN cord-257899-l866puqk 63 20 in in IN cord-257899-l866puqk 63 21 the the DT cord-257899-l866puqk 63 22 lysosomes lysosome NNS cord-257899-l866puqk 63 23 after after IN cord-257899-l866puqk 63 24 the the DT cord-257899-l866puqk 63 25 phagocytosis phagocytosis NN cord-257899-l866puqk 63 26 of of IN cord-257899-l866puqk 63 27 particles particle NNS cord-257899-l866puqk 63 28 and and CC cord-257899-l866puqk 63 29 the the DT cord-257899-l866puqk 63 30 generation generation NN cord-257899-l866puqk 63 31 of of IN cord-257899-l866puqk 63 32 reactive reactive JJ cord-257899-l866puqk 63 33 oxygen oxygen NN cord-257899-l866puqk 63 34 species specie NNS cord-257899-l866puqk 63 35 , , , cord-257899-l866puqk 63 36 resulting result VBG cord-257899-l866puqk 63 37 in in IN cord-257899-l866puqk 63 38 the the DT cord-257899-l866puqk 63 39 release release NN cord-257899-l866puqk 63 40 of of IN cord-257899-l866puqk 63 41 inflammatory inflammatory JJ cord-257899-l866puqk 63 42 cytokines cytokine NNS cord-257899-l866puqk 63 43 and and CC cord-257899-l866puqk 63 44 the the DT cord-257899-l866puqk 63 45 activation activation NN cord-257899-l866puqk 63 46 of of IN cord-257899-l866puqk 63 47 immune immune JJ cord-257899-l866puqk 63 48 cells cell NNS cord-257899-l866puqk 63 49 . . . cord-257899-l866puqk 64 1 Furthermore furthermore RB cord-257899-l866puqk 64 2 , , , cord-257899-l866puqk 64 3 they -PRON- PRP cord-257899-l866puqk 64 4 discussed discuss VBD cord-257899-l866puqk 64 5 the the DT cord-257899-l866puqk 64 6 possibility possibility NN cord-257899-l866puqk 64 7 of of IN cord-257899-l866puqk 64 8 the the DT cord-257899-l866puqk 64 9 enhancement enhancement NN cord-257899-l866puqk 64 10 of of IN cord-257899-l866puqk 64 11 anti anti JJ cord-257899-l866puqk 64 12 - - JJ cord-257899-l866puqk 64 13 cancer cancer JJ cord-257899-l866puqk 64 14 immunity immunity NN cord-257899-l866puqk 64 15 when when WRB cord-257899-l866puqk 64 16 combined combine VBN cord-257899-l866puqk 64 17 with with IN cord-257899-l866puqk 64 18 tumor tumor NN cord-257899-l866puqk 64 19 - - HYPH cord-257899-l866puqk 64 20 specific specific JJ cord-257899-l866puqk 64 21 antigens antigen NNS cord-257899-l866puqk 64 22 into into IN cord-257899-l866puqk 64 23 ZnO ZnO NNP cord-257899-l866puqk 64 24 NPs NPs NNP cord-257899-l866puqk 64 25 , , , cord-257899-l866puqk 64 26 although although IN cord-257899-l866puqk 64 27 the the DT cord-257899-l866puqk 64 28 potential potential JJ cord-257899-l866puqk 64 29 toxicity toxicity NN cord-257899-l866puqk 64 30 and and CC cord-257899-l866puqk 64 31 biodistribution biodistribution NN cord-257899-l866puqk 64 32 of of IN cord-257899-l866puqk 64 33 the the DT cord-257899-l866puqk 64 34 ZnO ZnO NNP cord-257899-l866puqk 64 35 NPs NPs NNP cord-257899-l866puqk 64 36 during during IN cord-257899-l866puqk 64 37 in in IN cord-257899-l866puqk 64 38 vivo vivo NNP cord-257899-l866puqk 64 39 studies study NNS cord-257899-l866puqk 64 40 should should MD cord-257899-l866puqk 64 41 be be VB cord-257899-l866puqk 64 42 thoroughly thoroughly RB cord-257899-l866puqk 64 43 verified verify VBN cord-257899-l866puqk 64 44 . . . cord-257899-l866puqk 65 1 As as IN cord-257899-l866puqk 65 2 vaccine vaccine NN cord-257899-l866puqk 65 3 development development NN cord-257899-l866puqk 65 4 pushes push VBZ cord-257899-l866puqk 65 5 toward toward IN cord-257899-l866puqk 65 6 less less RBR cord-257899-l866puqk 65 7 immunogenic immunogenic JJ cord-257899-l866puqk 65 8 components component NNS cord-257899-l866puqk 65 9 such such JJ cord-257899-l866puqk 65 10 as as IN cord-257899-l866puqk 65 11 nucleotide nucleotide NN cord-257899-l866puqk 65 12 - - HYPH cord-257899-l866puqk 65 13 based base VBN cord-257899-l866puqk 65 14 , , , cord-257899-l866puqk 65 15 peptide peptide NN cord-257899-l866puqk 65 16 - - HYPH cord-257899-l866puqk 65 17 based base VBN cord-257899-l866puqk 65 18 or or CC cord-257899-l866puqk 65 19 sub sub JJ cord-257899-l866puqk 65 20 - - JJ cord-257899-l866puqk 65 21 unit unit JJ cord-257899-l866puqk 65 22 vaccines vaccine NNS cord-257899-l866puqk 65 23 because because IN cord-257899-l866puqk 65 24 of of IN cord-257899-l866puqk 65 25 their -PRON- PRP$ cord-257899-l866puqk 65 26 side side NN cord-257899-l866puqk 65 27 effects effect NNS cord-257899-l866puqk 65 28 and and CC cord-257899-l866puqk 65 29 the the DT cord-257899-l866puqk 65 30 life life NN cord-257899-l866puqk 65 31 - - HYPH cord-257899-l866puqk 65 32 threatening threaten VBG cord-257899-l866puqk 65 33 risks risk NNS cord-257899-l866puqk 65 34 of of IN cord-257899-l866puqk 65 35 live live JJ cord-257899-l866puqk 65 36 attenuated attenuated JJ cord-257899-l866puqk 65 37 vaccines vaccine NNS cord-257899-l866puqk 65 38 , , , cord-257899-l866puqk 65 39 strategies strategy NNS cord-257899-l866puqk 65 40 to to TO cord-257899-l866puqk 65 41 boost boost VB cord-257899-l866puqk 65 42 both both DT cord-257899-l866puqk 65 43 innate innate JJ cord-257899-l866puqk 65 44 and and CC cord-257899-l866puqk 65 45 adaptive adaptive JJ cord-257899-l866puqk 65 46 immune immune JJ cord-257899-l866puqk 65 47 responses response NNS cord-257899-l866puqk 65 48 are be VBP cord-257899-l866puqk 65 49 increasingly increasingly RB cord-257899-l866puqk 65 50 needed need VBN cord-257899-l866puqk 65 51 . . . cord-257899-l866puqk 66 1 In in IN cord-257899-l866puqk 66 2 the the DT cord-257899-l866puqk 66 3 present present JJ cord-257899-l866puqk 66 4 Special Special NNP cord-257899-l866puqk 66 5 Issue Issue NNP cord-257899-l866puqk 66 6 , , , cord-257899-l866puqk 66 7 the the DT cord-257899-l866puqk 66 8 authors author NNS cord-257899-l866puqk 66 9 discuss discuss VBP cord-257899-l866puqk 66 10 the the DT cord-257899-l866puqk 66 11 modification modification NN cord-257899-l866puqk 66 12 of of IN cord-257899-l866puqk 66 13 nanomaterials nanomaterial NNS cord-257899-l866puqk 66 14 to to TO cord-257899-l866puqk 66 15 provide provide VB cord-257899-l866puqk 66 16 a a DT cord-257899-l866puqk 66 17 functional functional JJ cord-257899-l866puqk 66 18 and and CC cord-257899-l866puqk 66 19 stable stable JJ cord-257899-l866puqk 66 20 interface interface NN cord-257899-l866puqk 66 21 for for IN cord-257899-l866puqk 66 22 different different JJ cord-257899-l866puqk 66 23 applications application NNS cord-257899-l866puqk 66 24 and and CC cord-257899-l866puqk 66 25 strategies strategy NNS cord-257899-l866puqk 66 26 for for IN cord-257899-l866puqk 66 27 vaccination vaccination NN cord-257899-l866puqk 66 28 . . . cord-257899-l866puqk 67 1 We -PRON- PRP cord-257899-l866puqk 67 2 hope hope VBP cord-257899-l866puqk 67 3 this this DT cord-257899-l866puqk 67 4 Special Special NNP cord-257899-l866puqk 67 5 Issue Issue NNP cord-257899-l866puqk 67 6 , , , cord-257899-l866puqk 67 7 highlighting highlight VBG cord-257899-l866puqk 67 8 the the DT cord-257899-l866puqk 67 9 importance importance NN cord-257899-l866puqk 67 10 and and CC cord-257899-l866puqk 67 11 use use NN cord-257899-l866puqk 67 12 of of IN cord-257899-l866puqk 67 13 nanomaterials nanomaterial NNS cord-257899-l866puqk 67 14 as as IN cord-257899-l866puqk 67 15 a a DT cord-257899-l866puqk 67 16 platform platform NN cord-257899-l866puqk 67 17 technology technology NN cord-257899-l866puqk 67 18 , , , cord-257899-l866puqk 67 19 will will MD cord-257899-l866puqk 67 20 direct direct VB cord-257899-l866puqk 67 21 scientists scientist NNS cord-257899-l866puqk 67 22 as as RB cord-257899-l866puqk 67 23 well well RB cord-257899-l866puqk 67 24 as as IN cord-257899-l866puqk 67 25 manufacturers manufacturer NNS cord-257899-l866puqk 67 26 to to TO cord-257899-l866puqk 67 27 improve improve VB cord-257899-l866puqk 67 28 the the DT cord-257899-l866puqk 67 29 efficacy efficacy NN cord-257899-l866puqk 67 30 of of IN cord-257899-l866puqk 67 31 vaccines vaccine NNS cord-257899-l866puqk 67 32 that that WDT cord-257899-l866puqk 67 33 are be VBP cord-257899-l866puqk 67 34 currently currently RB cord-257899-l866puqk 67 35 under under IN cord-257899-l866puqk 67 36 development development NN cord-257899-l866puqk 67 37 against against IN cord-257899-l866puqk 67 38 modified modified JJ cord-257899-l866puqk 67 39 or or CC cord-257899-l866puqk 67 40 novel novel JJ cord-257899-l866puqk 67 41 diseases disease NNS cord-257899-l866puqk 67 42 . . . cord-257899-l866puqk 68 1 World World NNP cord-257899-l866puqk 68 2 Health Health NNP cord-257899-l866puqk 68 3 Organization Organization NNP cord-257899-l866puqk 68 4 , , , cord-257899-l866puqk 68 5 Global Global NNP cord-257899-l866puqk 68 6 Vaccine Vaccine NNP cord-257899-l866puqk 68 7 Action Action NNP cord-257899-l866puqk 68 8 Plan Plan NNP cord-257899-l866puqk 69 1 The the DT cord-257899-l866puqk 69 2 Role role NN cord-257899-l866puqk 69 3 of of IN cord-257899-l866puqk 69 4 Nanovaccine Nanovaccine NNP cord-257899-l866puqk 69 5 in in IN cord-257899-l866puqk 69 6 Cross Cross NNP cord-257899-l866puqk 69 7 - - HYPH cord-257899-l866puqk 69 8 Presentation Presentation NNP cord-257899-l866puqk 69 9 of of IN cord-257899-l866puqk 69 10 Antigen Antigen NNP cord-257899-l866puqk 69 11 - - HYPH cord-257899-l866puqk 69 12 Presenting Presenting NNP cord-257899-l866puqk 69 13 Cells cell NNS cord-257899-l866puqk 69 14 for for IN cord-257899-l866puqk 69 15 the the DT cord-257899-l866puqk 69 16 Activation Activation NNP cord-257899-l866puqk 69 17 of of IN cord-257899-l866puqk 69 18 CD8 CD8 NNP cord-257899-l866puqk 69 19 + + CC cord-257899-l866puqk 70 1 T T NNP cord-257899-l866puqk 70 2 Cell cell NN cord-257899-l866puqk 70 3 Responses response NNS cord-257899-l866puqk 71 1 Intranasal intranasal NN cord-257899-l866puqk 71 2 immunization immunization NN cord-257899-l866puqk 71 3 with with IN cord-257899-l866puqk 71 4 pneumococcal pneumococcal JJ cord-257899-l866puqk 71 5 surface surface NN cord-257899-l866puqk 71 6 protein protein NN cord-257899-l866puqk 71 7 A a NN cord-257899-l866puqk 71 8 in in IN cord-257899-l866puqk 71 9 the the DT cord-257899-l866puqk 71 10 presence presence NN cord-257899-l866puqk 71 11 of of IN cord-257899-l866puqk 71 12 nanoparticle nanoparticle NN cord-257899-l866puqk 71 13 forming form VBG cord-257899-l866puqk 71 14 polysorbitol polysorbitol NNP cord-257899-l866puqk 71 15 transporter transporter NN cord-257899-l866puqk 71 16 adjuvant adjuvant NN cord-257899-l866puqk 71 17 induces induce VBZ cord-257899-l866puqk 71 18 protective protective JJ cord-257899-l866puqk 71 19 immunity immunity NN cord-257899-l866puqk 71 20 against against IN cord-257899-l866puqk 71 21 the the DT cord-257899-l866puqk 71 22 Streptococcus Streptococcus NNP cord-257899-l866puqk 71 23 pneumoniae pneumoniae NN cord-257899-l866puqk 71 24 infection infection NN cord-257899-l866puqk 71 25 Advantages advantage NNS cord-257899-l866puqk 71 26 and and CC cord-257899-l866puqk 71 27 Limitations Limitations NNPS cord-257899-l866puqk 71 28 of of IN cord-257899-l866puqk 71 29 Integrated Integrated NNP cord-257899-l866puqk 71 30 Flagellin Flagellin NNP cord-257899-l866puqk 71 31 Adjuvants Adjuvants NNPS cord-257899-l866puqk 71 32 for for IN cord-257899-l866puqk 71 33 HIV HIV NNP cord-257899-l866puqk 71 34 - - HYPH cord-257899-l866puqk 71 35 Based base VBN cord-257899-l866puqk 71 36 Nanoparticle Nanoparticle NNP cord-257899-l866puqk 72 1 B b NN cord-257899-l866puqk 72 2 - - HYPH cord-257899-l866puqk 72 3 Cell cell NN cord-257899-l866puqk 72 4 Vaccines Vaccines NNPS cord-257899-l866puqk 72 5 Influenza Influenza NNP cord-257899-l866puqk 72 6 Virus Virus NNP cord-257899-l866puqk 72 7 - - HYPH cord-257899-l866puqk 72 8 Like like JJ cord-257899-l866puqk 72 9 Particles particle NNS cord-257899-l866puqk 72 10 Presenting present VBG cord-257899-l866puqk 72 11 both both DT cord-257899-l866puqk 72 12 Toxoplasma toxoplasma NN cord-257899-l866puqk 72 13 gondii gondii NN cord-257899-l866puqk 72 14 ROP4 ROP4 NNP cord-257899-l866puqk 72 15 and and CC cord-257899-l866puqk 72 16 ROP13 ROP13 NNP cord-257899-l866puqk 73 1 Enhance enhance VB cord-257899-l866puqk 73 2 Protection Protection NNP cord-257899-l866puqk 73 3 against against IN cord-257899-l866puqk 73 4 T. T. NNP cord-257899-l866puqk 73 5 gondii gondii NNP cord-257899-l866puqk 73 6 Infection Infection NNP cord-257899-l866puqk 73 7 Recent Recent NNP cord-257899-l866puqk 73 8 Advances Advances NNPS cord-257899-l866puqk 73 9 in in IN cord-257899-l866puqk 73 10 Nanovaccines Nanovaccines NNPS cord-257899-l866puqk 73 11 Using use VBG cord-257899-l866puqk 73 12 Biomimetic Biomimetic NNP cord-257899-l866puqk 73 13 Immunomodulatory Immunomodulatory NNP cord-257899-l866puqk 73 14 Materials material NNS cord-257899-l866puqk 74 1 Arming Arming NNP cord-257899-l866puqk 74 2 Filamentous Filamentous NNP cord-257899-l866puqk 74 3 Bacteriophage Bacteriophage NNP cord-257899-l866puqk 74 4 , , , cord-257899-l866puqk 74 5 a a DT cord-257899-l866puqk 74 6 Nature nature NN cord-257899-l866puqk 74 7 - - HYPH cord-257899-l866puqk 74 8 Made make VBN cord-257899-l866puqk 74 9 Nanoparticle Nanoparticle NNP cord-257899-l866puqk 74 10 , , , cord-257899-l866puqk 74 11 for for IN cord-257899-l866puqk 74 12 New New NNP cord-257899-l866puqk 74 13 Vaccine Vaccine NNP cord-257899-l866puqk 74 14 and and CC cord-257899-l866puqk 74 15 Immunotherapeutic Immunotherapeutic NNP cord-257899-l866puqk 74 16 Strategies strategy NNS cord-257899-l866puqk 75 1 Engineered engineer VBN cord-257899-l866puqk 75 2 Nanodelivery Nanodelivery NNP cord-257899-l866puqk 75 3 Systems Systems NNPS cord-257899-l866puqk 75 4 to to TO cord-257899-l866puqk 75 5 Improve improve VB cord-257899-l866puqk 75 6 DNA DNA NNP cord-257899-l866puqk 75 7 Vaccine Vaccine NNP cord-257899-l866puqk 75 8 Technologies Technologies NNPS cord-257899-l866puqk 75 9 Norovirus Norovirus NNP cord-257899-l866puqk 76 1 Capsid Capsid NNP cord-257899-l866puqk 76 2 Protein Protein NNP cord-257899-l866puqk 76 3 - - HYPH cord-257899-l866puqk 76 4 Derived derive VBN cord-257899-l866puqk 76 5 Nanoparticles nanoparticle NNS cord-257899-l866puqk 76 6 and and CC cord-257899-l866puqk 76 7 Polymers polymer NNS cord-257899-l866puqk 76 8 as as IN cord-257899-l866puqk 76 9 Versatile Versatile NNP cord-257899-l866puqk 76 10 Platforms Platforms NNPS cord-257899-l866puqk 76 11 for for IN cord-257899-l866puqk 76 12 Antigen Antigen NNP cord-257899-l866puqk 76 13 Presentation Presentation NNP cord-257899-l866puqk 76 14 and and CC cord-257899-l866puqk 76 15 Vaccine Vaccine NNP cord-257899-l866puqk 76 16 Development Development NNP cord-257899-l866puqk 76 17 Comprehensive Comprehensive NNP cord-257899-l866puqk 76 18 Analysis Analysis NNP cord-257899-l866puqk 76 19 of of IN cord-257899-l866puqk 76 20 the the DT cord-257899-l866puqk 76 21 Safety Safety NNP cord-257899-l866puqk 76 22 Profile Profile NNP cord-257899-l866puqk 76 23 of of IN cord-257899-l866puqk 76 24 a a DT cord-257899-l866puqk 76 25 Single Single NNP cord-257899-l866puqk 76 26 - - HYPH cord-257899-l866puqk 76 27 Stranded Stranded NNP cord-257899-l866puqk 76 28 RNA RNA NNP cord-257899-l866puqk 76 29 Nano Nano NNP cord-257899-l866puqk 76 30 - - HYPH cord-257899-l866puqk 76 31 Structure Structure NNP cord-257899-l866puqk 76 32 Adjuvant Adjuvant NNP cord-257899-l866puqk 76 33 Application Application NNP cord-257899-l866puqk 76 34 of of IN cord-257899-l866puqk 76 35 ZnO ZnO NNP cord-257899-l866puqk 76 36 - - HYPH cord-257899-l866puqk 76 37 Based base VBN cord-257899-l866puqk 76 38 Nanocomposites Nanocomposites NNPS cord-257899-l866puqk 76 39 for for IN cord-257899-l866puqk 76 40 Vaccines Vaccines NNPS cord-257899-l866puqk 76 41 and and CC cord-257899-l866puqk 76 42 Cancer Cancer NNP cord-257899-l866puqk 76 43 Immunotherapy Immunotherapy NNP cord-257899-l866puqk 77 1 This this DT cord-257899-l866puqk 77 2 article article NN cord-257899-l866puqk 77 3 is be VBZ cord-257899-l866puqk 77 4 an an DT cord-257899-l866puqk 77 5 open open JJ cord-257899-l866puqk 77 6 access access NN cord-257899-l866puqk 77 7 article article NN cord-257899-l866puqk 77 8 distributed distribute VBN cord-257899-l866puqk 77 9 under under IN cord-257899-l866puqk 77 10 the the DT cord-257899-l866puqk 77 11 terms term NNS cord-257899-l866puqk 77 12 and and CC cord-257899-l866puqk 77 13 conditions condition NNS cord-257899-l866puqk 77 14 of of IN cord-257899-l866puqk 77 15 the the DT cord-257899-l866puqk 77 16 Creative Creative NNP cord-257899-l866puqk 77 17 Commons Commons NNP cord-257899-l866puqk 77 18 Attribution Attribution NNP cord-257899-l866puqk 77 19 ( ( -LRB- cord-257899-l866puqk 77 20 CC CC NNP cord-257899-l866puqk 77 21 BY by IN cord-257899-l866puqk 77 22 ) ) -RRB- cord-257899-l866puqk 77 23 license license NN cord-257899-l866puqk 77 24 We -PRON- PRP cord-257899-l866puqk 77 25 wish wish VBP cord-257899-l866puqk 77 26 to to TO cord-257899-l866puqk 77 27 express express VB cord-257899-l866puqk 77 28 sincere sincere JJ cord-257899-l866puqk 77 29 thanks thank NNS cord-257899-l866puqk 77 30 to to IN cord-257899-l866puqk 77 31 all all DT cord-257899-l866puqk 77 32 authors author NNS cord-257899-l866puqk 77 33 for for IN cord-257899-l866puqk 77 34 their -PRON- PRP$ cord-257899-l866puqk 77 35 contribution contribution NN cord-257899-l866puqk 77 36 to to IN cord-257899-l866puqk 77 37 this this DT cord-257899-l866puqk 77 38 Special Special NNP cord-257899-l866puqk 77 39 Issue Issue NNP cord-257899-l866puqk 77 40 , , , cord-257899-l866puqk 77 41 entitled entitle VBN cord-257899-l866puqk 77 42 ' ' `` cord-257899-l866puqk 77 43 Nanoparticles nanoparticle NNS cord-257899-l866puqk 77 44 to to TO cord-257899-l866puqk 77 45 Improve improve VB cord-257899-l866puqk 77 46 the the DT cord-257899-l866puqk 77 47 Efficacy Efficacy NNP cord-257899-l866puqk 77 48 of of IN cord-257899-l866puqk 77 49 Vaccine Vaccine NNP cord-257899-l866puqk 77 50 ' ' '' cord-257899-l866puqk 77 51 . . . cord-257899-l866puqk 78 1 We -PRON- PRP cord-257899-l866puqk 78 2 are be VBP cord-257899-l866puqk 78 3 also also RB cord-257899-l866puqk 78 4 pleased pleased JJ cord-257899-l866puqk 78 5 to to TO cord-257899-l866puqk 78 6 acknowledge acknowledge VB cord-257899-l866puqk 78 7 all all PDT cord-257899-l866puqk 78 8 the the DT cord-257899-l866puqk 78 9 Editorial Editorial NNP cord-257899-l866puqk 78 10 Office Office NNP cord-257899-l866puqk 78 11 team team NN cord-257899-l866puqk 78 12 members member NNS cord-257899-l866puqk 78 13 for for IN cord-257899-l866puqk 78 14 their -PRON- PRP$ cord-257899-l866puqk 78 15 great great JJ cord-257899-l866puqk 78 16 help help NN cord-257899-l866puqk 78 17 and and CC cord-257899-l866puqk 78 18 support support NN cord-257899-l866puqk 78 19 during during IN cord-257899-l866puqk 78 20 the the DT cord-257899-l866puqk 78 21 peer peer NN cord-257899-l866puqk 78 22 - - HYPH cord-257899-l866puqk 78 23 review review NN cord-257899-l866puqk 78 24 process process NN cord-257899-l866puqk 78 25 . . . cord-257899-l866puqk 79 1 The the DT cord-257899-l866puqk 79 2 authors author NNS cord-257899-l866puqk 79 3 declare declare VBP cord-257899-l866puqk 79 4 no no DT cord-257899-l866puqk 79 5 conflict conflict NN cord-257899-l866puqk 79 6 of of IN cord-257899-l866puqk 79 7 interest interest NN cord-257899-l866puqk 79 8 . . .